BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1114 (prsA) DE:ribose-phosphate pyrophosphokinase (prsA)
(282 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||F75020 ribose-phosphate pyrophosphokinase (prsa) PAB1114 - ... 555 e-157
pir||C71207 probable ribose-phosphate pyrophosphokinase - Pyroco... 453 e-126
dbj|BAA24158.1| (D78364) Pk-RPPK [Pyrococcus sp.] 414 e-115
pir||E64470 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) - Me... 204 9e-52
gb|AAK41307.1| Ribose phosphate pyrophosphokinase [Sulfolobus so... 203 2e-51
pir||G69204 ribose-phosphate pyrophosphokinase - Methanobacteriu... 182 6e-45
gi|11499014 ribose-phosphate pyrophosphokinase (prsA-2) [Archaeo... 177 1e-43
pir||A72569 probable ribose-phosphate pyrophosphokinase APE1834 ... 175 7e-43
emb|CAC11266.1| (AL445063) RIBOSE-PHOSPHATE PYROPHOSPHOKINASE re... 154 9e-37
pir||E81365 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) Cj09... 153 2e-36
sp|P42816|KPRS_BACCL RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 153 2e-36
pir||B70441 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) - Aq... 151 1e-35
gb|AAB64352.1| (U76387) PRPP synthetase [Corynebacterium ammonia... 149 3e-35
pir||F81146 probable ribose-phosphate pyrophosphokinase (EC 2.7.... 145 4e-34
sp|Q55848|KPRS_SYNY3 RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 145 6e-34
sp|P14193|KPRS_BACSU RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 145 6e-34
gb|AAF81335.1|AC007767_15 (AC007767) Identical to ribose-phospha... 143 2e-33
sp|Q42583|KPR2_ARATH RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2 (PHOSP... 143 2e-33
dbj|BAB03785.1| (AP001507) phosphoribosyl pyrophosphate syntheta... 143 2e-33
pir||G82921 phosphoribosylpyrophosphate synthetase UU193 [import... 143 2e-33
pir||D72229 phosphoribosyl pyrophosphate synthetase - Thermotoga... 142 4e-33
pir||G83063 ribose-phosphate pyrophosphokinase PA4670 [imported]... 141 1e-32
sp|Q42581|KPR1_ARATH RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1 (PHOSP... 140 1e-32
pir||E71903 phosphoribosyl pyrophosphate synthetase - Helicobact... 140 1e-32
sp|P56184|KPRS_HELPY RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 140 2e-32
gb|AAA62181.1| (M92842) prs [Listeria monocytogenes] 139 4e-32
gb|AAF15359.1|AF201954_1 (AF201954) phosphoribosylpyrophosphate ... 139 4e-32
sp|P44328|KPRS_HAEIN RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 138 6e-32
emb|CAB43599.1| (AJ006940) phosphoribosyl pyrophosphate synthase... 137 2e-31
emb|CAB43600.1| (AJ006941) phosphoribosyl pyrophosphate synthase... 137 2e-31
sp|Q59988|KPRS_SYNP7 RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 136 2e-31
sp|O64888|KPR3_ARATH PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE... 136 3e-31
gi|6981418 phophoribosylpyrophosphate synthetase, subunit II [Ra... 136 4e-31
gb|AAA41961.1| (M29393) phosphoribosylphosphate synthetase (PRPS... 136 4e-31
gi|4506129 phosphoribosyl pyrophosphate synthetase 2 [Homo sapie... 135 5e-31
gi|11421042 phosphoribosyl pyrophosphate synthetase 2 [Homo sapi... 135 5e-31
gb|AAA98523.1| (U54642) phosphoribosylpyrophosphate synthetase [... 135 6e-31
gb|AAF50223.1| (AE003551) CG6767 gene product [alt 1] [Drosophil... 135 6e-31
pir||S73408 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) prs ... 134 8e-31
sp|P75044|KPRS_MYCPN RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 134 8e-31
emb|CAB95916.1| (AL359989) ribose-phosphate pyrophosphokinase [S... 134 1e-30
gi|4506127 phosphoribosyl pyrophosphate synthetase 1 [Homo sapie... 133 2e-30
pir||D70622 probable prsA protein - Mycobacterium tuberculosis (... 133 2e-30
pir||F82109 ribose-phosphate pyrophosphokinase VC2183 [imported]... 133 3e-30
gb|AAA24431.1| (M13174) phosphoribosylpyrophosphate synthetase (... 130 2e-29
sp|P15849|KPRS_SALTY RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 129 4e-29
sp|P08330|KPRS_ECOLI RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 129 4e-29
sp|P47304|KPRS_MYCGE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 128 6e-29
pir||B75393 ribose-phosphate pyrophosphokinase - Deinococcus rad... 128 6e-29
gi|6320946 ribose-phosphate pyrophosphokinase 2; Prs2p [Saccharo... 127 1e-28
sp|P21108|KPR3_HUMAN RIBOSE-PHOSPHATE PYROPHOSPHOKINASE III (PHO... 127 1e-28
pir||T16763 hypothetical protein R151.2 - Caenorhabditis elegans... 127 1e-28
dbj|BAB12886.1| (AP001118) ribose-phosphate pyrophosphokinase [B... 127 1e-28
sp|P57266|KPRS_BUCAI RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 127 1e-28
emb|CAC04170.1| (AJ245726) phosphoribosyl diphosphate synthase i... 126 3e-28
gb|AAG20333.1| (AE005107) ribose phosphate pyrophosphokinase; Pr... 125 7e-28
gi|6319403 ribose-phosphate pyrophosphokinase 4; Prs4p [Saccharo... 124 1e-27
pir||E82532 phosphoribosyl pyrophosphate synthetase XF2644 [impo... 123 3e-27
gb|AAF50224.1| (AE003551) CG6767 gene product [alt 2] [Drosophil... 122 6e-27
gi|6321776 ribose-phosphate pyrophosphokinase 3; Prs3p [Saccharo... 121 8e-27
pir||T41036 ribose-phosphate pyrophosphokinase - fission yeast ... 119 4e-26
gi|11498197 ribose-phosphate pyrophosphokinase (prsA-1) [Archaeo... 118 5e-26
gb|AAA29262.1| (M76553) phosphoribosylpyrophosphate synthetase [... 117 2e-25
pir||S60393 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PRS1... 116 2e-25
sp|P46585|KPR1_CANAL RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1 (PHOSP... 116 3e-25
gb|AAD03403.1| (AF042173) phosphoribosyl pyrophosphate synthetas... 115 8e-25
pir||T40366 probable ribose-phosphate pyrophosphokinase - fissio... 111 7e-24
emb|CAC14347.1| (AL445945) ribose-phosphate pyrophosphokinase [S... 107 2e-22
gi|4506133 phosphoribosyl pyrophosphate synthetase-associated pr... 104 2e-21
dbj|BAA19517.1| (D84434) 41-kDa phosphoribosylpyrophosphate synt... 101 1e-20
gi|4506131 phosphoribosyl pyrophosphate synthetase-associated pr... 97 3e-19
gi|11424272 phosphoribosyl pyrophosphate synthetase-associated p... 97 3e-19
pir||A53433 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) 39K ... 92 5e-18
pir||T26164 hypothetical protein W04G3.5 - Caenorhabditis elegan... 84 1e-15
pir||G70167 phosphoribosyl pyrophosphate synthetase (prs) homolo... 80 2e-14
sp|P41831|KPRS_SCHPO RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHO... 71 1e-11
>pir||F75020 ribose-phosphate pyrophosphokinase (prsa) PAB1114 - Pyrococcus
abyssi (strain Orsay) >gi|5459118|emb|CAB50604.1|
(AJ248288) ribose-phosphate pyrophosphokinase (prsA)
[Pyrococcus abyssi]
Length = 282
Score = 555 bits (1415), Expect = e-157
Identities = 282/282 (100%), Positives = 282/282 (100%)
Query: 1 MFVIGSGAKHLEEEISRHGNLINVEIKKFPDGEKYVRVLERGKEAIVIQSTYHPQDENLI 60
MFVIGSGAKHLEEEISRHGNLINVEIKKFPDGEKYVRVLERGKEAIVIQSTYHPQDENLI
Sbjct: 1 MFVIGSGAKHLEEEISRHGNLINVEIKKFPDGEKYVRVLERGKEAIVIQSTYHPQDENLI 60
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDI 120
EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDI
Sbjct: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDI 120
Query: 121 HNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLEYSHF 180
HNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLEYSHF
Sbjct: 121 HNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLEYSHF 180
Query: 181 EKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGV 240
EKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGV
Sbjct: 181 EKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGV 240
Query: 241 FAEGAIERVSKAVNELAVTNTIPTEVSKISIVDYIVKLGEKE 282
FAEGAIERVSKAVNELAVTNTIPTEVSKISIVDYIVKLGEKE
Sbjct: 241 FAEGAIERVSKAVNELAVTNTIPTEVSKISIVDYIVKLGEKE 282
>pir||C71207 probable ribose-phosphate pyrophosphokinase - Pyrococcus horikoshii
>gi|3258367|dbj|BAA31050.1| (AP000007) 287aa long
hypothetical ribose-phosphate pyrophosphokinase
[Pyrococcus horikoshii]
Length = 287
Score = 453 bits (1152), Expect = e-126
Identities = 220/277 (79%), Positives = 254/277 (91%)
Query: 1 MFVIGSGAKHLEEEISRHGNLINVEIKKFPDGEKYVRVLERGKEAIVIQSTYHPQDENLI 60
+FVIGSGAKHLEEEIS++ ++ EIKKFPDGEKYVR+LE G+E IV+QSTY PQDE+LI
Sbjct: 4 VFVIGSGAKHLEEEISKNAKILKTEIKKFPDGEKYVRILEHGEEVIVVQSTYRPQDEHLI 63
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDI 120
E +++GDAL EAGF+KLK+V+PYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDI
Sbjct: 64 ETIIIGDALKEAGFEKLKLVVPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDI 123
Query: 121 HNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLEYSHF 180
HNPKTL+ FPG A NIYPA+ IA YF+DKL GL+LAPD+GALERAK VA +LGLEYSHF
Sbjct: 124 HNPKTLDFFPGKAVNIYPAKVIAEYFRDKLENGLVLAPDRGALERAKEVANILGLEYSHF 183
Query: 181 EKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGV 240
EKERISPTEV+M PVDV+V G+NVLIVDDIISTGGTMI+AA IL++LGA+++FVVATHGV
Sbjct: 184 EKERISPTEVKMTPVDVNVKGRNVLIVDDIISTGGTMIRAAEILKDLGAEKVFVVATHGV 243
Query: 241 FAEGAIERVSKAVNELAVTNTIPTEVSKISIVDYIVK 277
FAEGAIERVSKAV+ELAVTNTIPT+VSKISIV I++
Sbjct: 244 FAEGAIERVSKAVDELAVTNTIPTKVSKISIVPEIMR 280
>dbj|BAA24158.1| (D78364) Pk-RPPK [Pyrococcus sp.]
Length = 280
Score = 414 bits (1054), Expect = e-115
Identities = 200/279 (71%), Positives = 240/279 (85%), Gaps = 1/279 (0%)
Query: 1 MFVIGSGAKHLEEEISRHG-NLINVEIKKFPDGEKYVRVLERGKEAIVIQSTYHPQDENL 59
MF++GSG KH E+E+ G ++ VEIK+FPDGEKYVRV+ G EA V+ ST++PQDE +
Sbjct: 1 MFLLGSGGKHFEDELRNAGAKILEVEIKRFPDGEKYVRVMGNGDEATVVSSTFYPQDEKI 60
Query: 60 IEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFD 119
+E LLLGDAL E GF+KLK+V+PY AYSRQDRVTK+GEPISVRA+M+ LG+YY+ELY+FD
Sbjct: 61 VELLLLGDALREKGFEKLKLVVPYFAYSRQDRVTKDGEPISVRAVMRALGIYYEELYIFD 120
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLEYSH 179
HNP+TL FPG A N+ PA I YF++KLG+GL+LAPDKGALERA+ VAEVLGLEYSH
Sbjct: 121 THNPETLRFFPGKAVNVSPARVIGEYFREKLGDGLVLAPDKGALERARAVAEVLGLEYSH 180
Query: 180 FEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHG 239
FEK RISPTEV M PVDVDV GKNVLIVDDIISTGGTM++AA +LR+LGAK+I+V ATHG
Sbjct: 181 FEKRRISPTEVEMHPVDVDVKGKNVLIVDDIISTGGTMVRAAELLRKLGAKKIYVSATHG 240
Query: 240 VFAEGAIERVSKAVNELAVTNTIPTEVSKISIVDYIVKL 278
VFAEGAIERVS+AV+ELAVTNTIPT VS+ISIV ++KL
Sbjct: 241 VFAEGAIERVSRAVDELAVTNTIPTPVSRISIVPELLKL 279
>pir||E64470 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) - Methanococcus
jannaschii >gi|1592010|gb|AAB99374.1| (U67576)
ribose-phosphate pyrophosphokinase, (prsA)
[Methanococcus jannaschii]
Length = 291
Score = 204 bits (514), Expect = 9e-52
Identities = 118/283 (41%), Positives = 176/283 (61%), Gaps = 10/283 (3%)
Query: 3 VIGSGAKHLEEEISRHGN--LINVEIKKFPDGEKYVRVLER--GKEAIVIQSTYHPQDEN 58
V GS +++L ++++ N L VE K+FPD E YVR+++ EA++I +T Q++
Sbjct: 11 VSGSQSQNLAFKVAKLLNTKLTRVEYKRFPDNEIYVRIVDEINDDEAVII-NTQKNQNDA 69
Query: 59 LIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVF 118
++E +LL DAL + G KK+ +V PYLAY+RQD+ GE IS+RA+ K+ D+L
Sbjct: 70 IVETILLCDALRDEGVKKITLVAPYLAYARQDKKFNPGEAISIRALAKIYSNIVDKLITI 129
Query: 119 DIHNPKTLEHF--PGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLE 176
+ H + F P I + P +A Y KDKL + ++LAPDKGALE AK +++L E
Sbjct: 130 NPHETHIKDFFTIPFIYGDAVPK--LAEYVKDKLNDPIVLAPDKGALEFAKTASKILNAE 187
Query: 177 YSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVA 236
Y + EK R+SPTE+++ P +D ++V IVDDIISTGGTM A +L+E GAK+I
Sbjct: 188 YDYLEKTRLSPTEIQIAPKTLDAKDRDVFIVDDIISTGGTMATAVKLLKEQGAKKIIAAC 247
Query: 237 THGVFAEGAIERV-SKAVNELAVTNTIPTEVSKISIVDYIVKL 278
H V A+ ++ S V E+ T+T +EVSK+S+ + IV L
Sbjct: 248 VHPVLIGDALNKLYSAGVEEVVGTDTYLSEVSKVSVAEVIVDL 290
>gb|AAK41307.1| Ribose phosphate pyrophosphokinase [Sulfolobus solfataricus]
Length = 294
Score = 203 bits (511), Expect = 2e-51
Identities = 117/282 (41%), Positives = 179/282 (62%), Gaps = 9/282 (3%)
Query: 1 MFVIGSGAKH-LEEEISRHGN--LINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
M +IG A + ++E +S+ + L+ VE K FPDGE Y+RV R +E +++Q+T +PQ
Sbjct: 4 MIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTDYPQ 63
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDE 114
D++LIE L+ + + + G KKL ++PYLAYSRQDR K+GE IS++ I+ +L + +
Sbjct: 64 DKHLIELFLIAETIRDLGAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVGVNT 123
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLG 174
L V + H P+ L +F G K ++P IA K+ + + ILAPD+GAL+RA+++AE +
Sbjct: 124 LVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIEDPFILAPDRGALDRARKIAEEIN 183
Query: 175 LEYSHFEKERISPT-EVRMKPV-DVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEI 232
YS+ EKER T EVR+K ++++ GK+V+I+DDIISTGGT+++A + LGAK +
Sbjct: 184 APYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGAKSV 243
Query: 233 FVVATHGVFAEGAIERVSK-AVNELAVTNTIPTEVSKISIVD 273
A H + GA ER+ + V L TNTI I +D
Sbjct: 244 TAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITID 285
>pir||G69204 ribose-phosphate pyrophosphokinase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621874|gb|AAB85286.1| (AE000856) ribose-phosphate
pyrophosphokinase [Methanobacterium thermoautotrophicum]
Length = 285
Score = 182 bits (456), Expect = 6e-45
Identities = 104/258 (40%), Positives = 153/258 (58%), Gaps = 4/258 (1%)
Query: 21 LINVEIKKFPDGEKYVRVLERGK-EAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKI 79
L VE +KFPDGE+Y+RV E + E V+QST +PQDENL+E L + + L + G ++
Sbjct: 23 LCPVETRKFPDGERYIRVKEEVEGEVTVVQSTGYPQDENLMELLFMIENLKDLGADYVRA 82
Query: 80 VIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYDELYVFDIHNPKTLEHFPGIAKNIYP 138
IPY Y RQ+R K GE +S + + +L DE+ ++H E F + +
Sbjct: 83 AIPYFGYGRQERRFKSGEAVSAKIVAHLLEAAGADEIVTVNLHENCLSEFFRVPVRELSA 142
Query: 139 AEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVD 198
IA + L + +I+APDKGAL A+ V+++LG E + EK RISP V + D+D
Sbjct: 143 MPLIAEHISF-LDDPVIIAPDKGALGHAREVSDILGCECDYMEKVRISPEVVETRVSDLD 201
Query: 199 VNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERV-SKAVNELA 257
V GK+ ++VDDIISTGGT++ AA IL + GA I V H V E A+ ++ S V +
Sbjct: 202 VEGKDAVVVDDIISTGGTIVNAAGILGKCGASSITVCCVHPVLVEDALLKIFSAGVERVI 261
Query: 258 VTNTIPTEVSKISIVDYI 275
T+T+ ++VS+IS+ I
Sbjct: 262 ATDTLKSDVSEISVAPLI 279
>gi|11499014 ribose-phosphate pyrophosphokinase (prsA-2) [Archaeoglobus
fulgidus] >gi|7434670|pir||B69427 ribose-phosphate
pyrophosphokinase (prsA-2) homolog - Archaeoglobus
fulgidus >gi|2649160|gb|AAB89836.1| (AE001006)
ribose-phosphate pyrophosphokinase (prsA-2)
[Archaeoglobus fulgidus]
Length = 271
Score = 177 bits (444), Expect = 1e-43
Identities = 100/252 (39%), Positives = 151/252 (59%), Gaps = 13/252 (5%)
Query: 27 KKFPDGEKYVRVLERGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAY 86
KKFPDGE YVRV+E KE +V+ S +E+LI + D L A K V+PY+ Y
Sbjct: 30 KKFPDGELYVRVME--KEGVVVGSIN--SNEDLIALIFALDVLENA-----KAVVPYMGY 80
Query: 87 SRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYF 146
+RQD+V +EGE +S++ + +ML DE+ +IH+ HF + KN+ + YF
Sbjct: 81 ARQDKVFQEGEAVSIKIVAEMLESRADEVVTVNIHSSDAASHFSKL-KNLDAMPLVGEYF 139
Query: 147 KDKLGEGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLI 206
K + ++++PDKG++ER K A+ G E+ + EK RI T V + P +DV G++V+I
Sbjct: 140 AGK--DVVMISPDKGSMERVKTAAKHAGCEWDYMEKRRIDATTVEITPKTIDVEGRDVVI 197
Query: 207 VDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAE-GAIERVSKAVNELAVTNTIPTE 265
VDDIISTGGT+ +AA IL LGAK + H V AE AI+ + + ++ T+T+
Sbjct: 198 VDDIISTGGTVAEAARILYGLGAKSVSAACVHAVLAENAAIKLFNAGIKDIIATDTVECA 257
Query: 266 VSKISIVDYIVK 277
S+IS+ + I +
Sbjct: 258 FSRISVAELIAE 269
>pir||A72569 probable ribose-phosphate pyrophosphokinase APE1834 - Aeropyrum
pernix (strain K1) >gi|5105525|dbj|BAA80838.1|
(AP000062) 322aa long hypothetical ribose-phosphate
pyrophosphokinase [Aeropyrum pernix]
Length = 322
Score = 175 bits (438), Expect = 7e-43
Identities = 111/275 (40%), Positives = 160/275 (57%), Gaps = 10/275 (3%)
Query: 5 GSGAKHLEEEISRHGNLINVE--IKKFPDGEKYVRV---LERGKEAIVIQSTYHPQDENL 59
GS + E +SR+ L V+ K FPD E+YVR+ + AIV+QS P +L
Sbjct: 27 GSASAEFSEGLSRNMGLKLVKPVFKLFPDEEEYVRIEGDISGFTGAIVVQSFERPASRSL 86
Query: 60 IEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVF 118
+ +LL+ DAL EAG ++ ++ PY+ Y+RQDRV GEP+SVRA+M+ L Y+ L
Sbjct: 87 VYSLLIADALKEAGVGRIVLMAPYMGYTRQDRVFLPGEPVSVRAVMRALASSGYNALASI 146
Query: 119 DIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG-LILAPDKGALERAKRVAEVLGL-E 176
++H L++F G NI+P + G+ +I+APDKG+L R +R+A G
Sbjct: 147 EVHKEYVLDYFDGSTLNIFPFTYMLKETGISCGDNTIIVAPDKGSLPRVERLARETGCRS 206
Query: 177 YSHFEKERISPT-EVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
Y + KER T EVR+ VD GKN ++VDDIISTGGT+ A+ L E GA +FV+
Sbjct: 207 YGYLVKERDRITGEVRLAKSTVDPRGKNAIVVDDIISTGGTIALASQWLLENGANSVFVL 266
Query: 236 ATHGVFAEGAIERVSKA-VNELAVTNTIPTEVSKI 269
A H + A E++ KA V+ + NT+P + SKI
Sbjct: 267 AAHYLGIGNAEEKMMKAGVSRVVTGNTLPRKPSKI 301
>emb|CAC11266.1| (AL445063) RIBOSE-PHOSPHATE PYROPHOSPHOKINASE related protein
[Thermoplasma acidophilum]
Length = 237
Score = 154 bits (386), Expect = 9e-37
Identities = 79/220 (35%), Positives = 133/220 (59%), Gaps = 1/220 (0%)
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDEL 115
D +IE +L A+ + K + I+ PY Y+RQ + + GEPIS + ++ Y +
Sbjct: 10 DAEIIEMILSLSAVRDYQVKSVNIIAPYYGYARQHQRYRRGEPISSQIFTEIFASYSTSI 69
Query: 116 YVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGL 175
DIH+ +TL + +++ +I ++++ + +++PD G L+R K VAE LG
Sbjct: 70 ATVDIHDEQTLSYSKVRFTDLHADRSIIDFYRH-VDIDYVVSPDDGGLQRVKHVAEALGK 128
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+Y + EK+RI V MK D+D+NGK VLI+DDIISTGGT+ K+++ILR+ GA +I+V
Sbjct: 129 KYFYIEKKRIDDRTVEMKAPDIDLNGKKVLILDDIISTGGTIAKSSSILRQKGASKIYVS 188
Query: 236 ATHGVFAEGAIERVSKAVNELAVTNTIPTEVSKISIVDYI 275
A HG+F + ++ + +E+ VT+T+ + S IS+ +
Sbjct: 189 AIHGLFVNSSESKILENADEIHVTDTVAGKFSDISVYQVV 228
>pir||E81365 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) Cj0918c [imported]
- Campylobacter jejuni (strain NCTC 11168)
>gi|6968355|emb|CAB73175.1| (AL139076) ribose-phosphate
pyrophosphokinase [Campylobacter jejuni]
Length = 309
Score = 153 bits (384), Expect = 2e-36
Identities = 96/271 (35%), Positives = 152/271 (55%), Gaps = 9/271 (3%)
Query: 2 FVIGSGAKHLE--EEISRHGNL--INVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
+ I SG+ ++E ++S++ +L + +K+F DGE V++ E RGK+ +IQST P
Sbjct: 4 YKIFSGSANVEFARQVSKYLSLPLSDAGVKRFSDGEISVQIDESVRGKDVFIIQSTCAPT 63
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYDE 114
++NL+E L+L DAL + + +IPY Y+RQDR PI+ + + ++ D
Sbjct: 64 NDNLMELLILTDALRRSSANSITAIIPYFGYARQDRKANPRVPITAKLVANLIQAAGIDR 123
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLIL-APDKGALERAKRVAEVL 173
+ D+H + F N+Y + +Y K K + I+ +PD G + RA+ VA+ L
Sbjct: 124 VATIDLHAGQIQGFFDIPVDNLYGSIVFNDYIKAKHFKNAIIGSPDIGGVARARSVAKHL 183
Query: 174 GLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIF 233
GL+ +K R E + + DV K V++VDDII T GT++KAA L+E GAK +
Sbjct: 184 GLDIVIVDKRREKANESEVMNIIGDVKDKEVILVDDIIDTAGTIVKAAEALKEKGAKSVM 243
Query: 234 VVATHGVFAEGAIERVSKAV-NELAVTNTIP 263
TH V + A ER++ V +EL VT+TIP
Sbjct: 244 ACCTHAVLSGKAYERIASGVLDELVVTDTIP 274
>sp|P42816|KPRS_BACCL RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|1075785|pir||S51152 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Bacillus caldolyticus
>gi|2117905|pir||JC5093 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Bacillus caldolyticus
>gi|633147|emb|CAA58682.1| (X83708) ribose-phosphate
pyrophosphokinase [Bacillus caldolyticus]
Length = 315
Score = 153 bits (383), Expect = 2e-36
Identities = 98/284 (34%), Positives = 152/284 (53%), Gaps = 8/284 (2%)
Query: 1 MFVIGSGAKHLEEEISRHG-NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDE 57
+F + S K +E G L + +F DGE + + E RG + VIQST P +E
Sbjct: 10 LFALNSNMKLAKEIAEVMGIELGKCSVSRFSDGEIQINIEESIRGDDVFVIQSTSVPVNE 69
Query: 58 NLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELY 116
+L+E L++ DAL A + + IV+PY Y+RQDR + PI+ + + +L +
Sbjct: 70 HLMELLIMIDALKRASARTINIVMPYYGYARQDRKARSRNPITAKLVANLLETAGASRVI 129
Query: 117 VFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDK-LGEGLILAPDKGALERAKRVAEVLGL 175
D+H P+ F ++ +A+YFK K L + ++++PD G + RA+++A+ L
Sbjct: 130 TLDLHAPQIQGFFDIPIDHLMGVPILADYFKSKQLEDIVVVSPDHGGVTRARKLADRLKA 189
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ +K R P + + V GK +++DDII T GT+ AAN L E GAKE++
Sbjct: 190 PIAIIDKRRPKPNVAEVMNIVGQVAGKTAILIDDIIDTAGTITLAANALAESGAKEVYAC 249
Query: 236 ATHGVFAEGAIERV-SKAVNELAVTNTIPTEVSKISIVDYIVKL 278
TH V + AIER+ S + EL VTN+I K +D IVKL
Sbjct: 250 CTHPVLSGPAIERIQSSKIKELVVTNSIALPEEK--KIDKIVKL 291
>pir||B70441 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) - Aquifex aeolicus
>gi|2983966|gb|AAC07513.1| (AE000748)
phosphoribosylpyrophosphate synthetase [Aquifex
aeolicus]
Length = 311
Score = 151 bits (377), Expect = 1e-35
Identities = 95/289 (32%), Positives = 155/289 (52%), Gaps = 11/289 (3%)
Query: 3 VIGSGAKHLEEEISRHGNL--INVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDEN 58
+ G+ K L EEI+ + L + I F DGE V++ E RG VI S +P + N
Sbjct: 7 IAGTSNKTLSEEIAGYLGLRLTDALITTFSDGEIRVQINESIRGYHVYVITSLSNPVNHN 66
Query: 59 LIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYV 117
L+E LL DA+ + K++ V+PY AY RQDR K PIS + + ++ + + V
Sbjct: 67 LMELLLTLDAVKRSSPKEITAVVPYYAYGRQDRQDKPRTPISAKLVADLIQKAGANRVIV 126
Query: 118 FDIHNPKTLEHFPGIAKNIYPAEAIANYFKDK--LGEGLILAPDKGALERAKRVAEVLGL 175
D+H+P+ F +++ + +Y + L ++++PD G ++RA+ +A LG
Sbjct: 127 VDLHSPQIQGFFDIPVEHLTAIPVLYDYIRKNVVLENPIVVSPDAGGVKRARDLANKLGC 186
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
K R P + + V D+ GK +IVDDII T GT++ AAN+L G K +
Sbjct: 187 GIGVILKRRPEPNKAEVMDVVGDIEGKEAIIVDDIIDTAGTLVAAANLLVNKGVKRVIAC 246
Query: 236 ATHGVFAEGAIERVSKA-VNELAVTNTIPT---EVSKISIVDYIVKLGE 280
ATHG+F+ A+ER++ + + ++ VTNT+P + K+ +V +GE
Sbjct: 247 ATHGIFSGPAVERLTNSPIEKVIVTNTLPVYEKKFGKLEVVSIAPLIGE 295
>gb|AAB64352.1| (U76387) PRPP synthetase [Corynebacterium ammoniagenes]
Length = 317
Score = 149 bits (373), Expect = 3e-35
Identities = 90/261 (34%), Positives = 146/261 (55%), Gaps = 7/261 (2%)
Query: 9 KHLEEEISRH--GNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALL 64
K L E+I++H L + +F DGE + + E RG + +IQST P +E+++E L+
Sbjct: 19 KELAEQIAKHIGVGLGKCSVDRFSDGEVQINIEESIRGCDVFIIQSTSFPVNEHIMELLI 78
Query: 65 LGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNP 123
+ DAL A K + IVIPY Y+RQDR + EPI+ + + +L + D+H P
Sbjct: 79 MIDALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVANLLETAGATRVITLDLHAP 138
Query: 124 KTLEHFPGIAKNIYPAEAIANYFKDK-LGEGLILAPDKGALERAKRVAEVLGLEYSHFEK 182
+ F ++ +++YF+ K L + +I++PD G + RA+++A+ L + +K
Sbjct: 139 QIQGFFDIPIDHLMGVPILSDYFETKGLKDIVIVSPDHGGVTRARKMADRLKAPIAIIDK 198
Query: 183 ERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFA 242
R P + + ++ GK L++DDII T GT+ AAN L E GA E++ TH V +
Sbjct: 199 RRPRPNVSEVMNIIGNIEGKTALLIDDIIDTAGTITLAANALVENGASEVYACCTHPVLS 258
Query: 243 EGAIERVSKA-VNELAVTNTI 262
AIER+ + + EL VTN+I
Sbjct: 259 GPAIERIQNSNIKELVVTNSI 279
>pir||F81146 probable ribose-phosphate pyrophosphokinase (EC 2.7.6.1) NMA1093
[imported] - Neisseria meningitidis (group B strain
MD58, group A strain Z2491) >gi|7226113|gb|AAF41286.1|
(AE002440) ribose-phosphate pyrophosphokinase [Neisseria
meningitidis MC58] >gi|7379788|emb|CAB84356.1|
(AL162755) putative ribose-phosphate pyrophosphokinase
[Neisseria meningitidis Z2491]
Length = 327
Score = 145 bits (363), Expect = 4e-34
Identities = 90/271 (33%), Positives = 143/271 (52%), Gaps = 8/271 (2%)
Query: 1 MFVIGSGAKHLEEEISRHGNLI--NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQD 56
M G+ L + + RH ++ N + KF DGE V +LE RG++ ++Q T P +
Sbjct: 8 MVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQPTCAPTN 67
Query: 57 ENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGE-PISVRAIMKML-GLYYDE 114
+NL+E L + DAL A ++ IPY Y+RQDR + PIS + + ML D
Sbjct: 68 DNLMEILTMADALKRASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANMLYSAGIDR 127
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGL-ILAPDKGALERAKRVAEVL 173
+ D+H + F NIY + N K + E L +++PD G + RA+ VA+ L
Sbjct: 128 VLTVDLHADQIQGFFDIPVDNIYATPILLNDIKQQRIENLTVVSPDIGGVVRARAVAKSL 187
Query: 174 GLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIF 233
+ + +K R + + D+ G+ LIVDD+I T T+ KAA L+E GA+ +
Sbjct: 188 NADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKERGAERVL 247
Query: 234 VVATHGVFAEGAIERV-SKAVNELAVTNTIP 263
A+H VF+ A+ R+ S ++++ VT+TIP
Sbjct: 248 AYASHAVFSGEAVSRIASSEIDQVVVTDTIP 278
>sp|Q55848|KPRS_SYNY3 RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|7434658|pir||S76660 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Synechocystis sp.
(strain PCC 6803) >gi|1001766|dbj|BAA10604.1| (D64004)
ribose-phosphate pyrophosphokinase [Synechocystis sp.]
Length = 333
Score = 145 bits (362), Expect = 6e-34
Identities = 89/270 (32%), Positives = 153/270 (55%), Gaps = 14/270 (5%)
Query: 5 GSGAKHLEEEISRHGNLINVEI-----KKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDE 57
GS L +E++R+ + ++I K+F DGE Y+++ E RG + +IQ HP ++
Sbjct: 30 GSSNPSLSQEVARY---LGMDIGPMLRKRFADGELYIQIQESIRGGDVYLIQPCCHPVND 86
Query: 58 NLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYDELY 116
NL+E L++ DA A +++ V+PY Y+R DR T E IS + + ++ G +
Sbjct: 87 NLMELLIMIDACRRASARQITAVLPYYGYARADRKTAGRESISAKLVANLITGAGAQRVL 146
Query: 117 VFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDK-LGEGLILAPDKGALERAKRVAEVLG- 174
D+H+ + +F ++Y + I +Y K K L + ++++PD G + RA+ A+ L
Sbjct: 147 AMDLHSAQIQGYFDIPCDHMYGSPVIIDYLKSKQLTDLVVVSPDVGGVARARAFAKKLND 206
Query: 175 LEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFV 234
+ +K R S + + DV+GK ++VDD+I T GT+ + + +LR GA++++
Sbjct: 207 APLAIIDKRRQSHNVAEVLNLIGDVDGKTAVLVDDMIDTAGTLSEGSRLLRAQGARQVYA 266
Query: 235 VATHGVFAEGAIERVSKAV-NELAVTNTIP 263
ATH VF+E AI R+S + E+ VTNTIP
Sbjct: 267 CATHAVFSEPAINRLSGGLFEEVIVTNTIP 296
>sp|P14193|KPRS_BACSU RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) (PRPP SYNTHETASE) >gi|66951|pir||KIBSRS
ribose-phosphate pyrophosphokinase (EC 2.7.6.1) prs -
Bacillus subtilis >gi|7546200|pdb|1DKR|B Chain B,
Crystal Structures Of Bacillus Subtilis
Phosphoribosylpyrophosphate Synthetase: Molecular Basis
Of Allosteric Inhibition And Activation.
>gi|7546199|pdb|1DKR|A Chain A, Crystal Structures Of
Bacillus Subtilis Phosphoribosylpyrophosphate
Synthetase: Molecular Basis Of Allosteric Inhibition And
Activation. >gi|7546201|pdb|1DKU|A Chain A, Crystal
Structures Of Bacillus Subtilis
Phosphoribosylpyrophosphate Synthetase: Molecular Basis
Of Allosteric Inhibition And Activation.
>gi|7546202|pdb|1DKU|B Chain B, Crystal Structures Of
Bacillus Subtilis Phosphoribosylpyrophosphate
Synthetase: Molecular Basis Of Allosteric Inhibition And
Activation. >gi|40218|emb|CAA34523.1| (X16518) PRPP
synthetase (AA 1-317) [Bacillus subtilis]
>gi|467440|dbj|BAA05286.1| (D26185)
'phosphoribosylpyrophosphate synthetase [Bacillus
subtilis] >gi|2632318|emb|CAB11827.1| (Z99104)
phosphoribosyl pyrophosphate synthetase [Bacillus
subtilis]
Length = 317
Score = 145 bits (362), Expect = 6e-34
Identities = 83/242 (34%), Positives = 136/242 (55%), Gaps = 5/242 (2%)
Query: 26 IKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPY 83
+ +F DGE + + E RG + +IQST P +E+++E L++ DAL A K + IVIPY
Sbjct: 38 VTRFSDGEVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPY 97
Query: 84 LAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAEAI 142
Y+RQDR + EPI+ + +L + D+H P+ F ++ +
Sbjct: 98 YGYARQDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPIL 157
Query: 143 ANYFKDK-LGEGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNG 201
YF+ K L + +I++PD G + RA+++A+ L + +K R P + + ++ G
Sbjct: 158 GEYFEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEG 217
Query: 202 KNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA-VNELAVTN 260
K +++DDII T GT+ AAN L E GAKE++ TH V + A+ER++ + + EL VTN
Sbjct: 218 KTAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVTN 277
Query: 261 TI 262
+I
Sbjct: 278 SI 279
>gb|AAF81335.1|AC007767_15 (AC007767) Identical to ribose-phosphate pyrophosphokinase 2
(phosphoribosyl pyrophosphate synthetase 2) (PRSII)
(fragment) from Arabidopsis thaliana gb|X92974. It
contains a phosphoribosyl transferase domain PF|00156.
ESTs gb|N65092, gb|AI994187 and>
Length = 400
Score = 143 bits (358), Expect = 2e-33
Identities = 92/269 (34%), Positives = 148/269 (54%), Gaps = 10/269 (3%)
Query: 5 GSGAKHLEEEISRHGNLI--NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L +EI+ + L V IK+F DGE YV++ E RG + ++Q T P +ENL+
Sbjct: 95 GTANPALSQEIAWYMGLELGKVSIKRFADGEIYVQLKESVRGCDVFLVQPTCTPTNENLM 154
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDELYVFD 119
E L++ DA A KK+ VIPY Y+R DR T+ E I+ + + ++ D + D
Sbjct: 155 ELLIMVDACRRASAKKVTAVIPYFGYARADRKTQGRESIAAKLVANLITEAGADRVLACD 214
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAEVLG-L 175
+H+ +++ +F ++Y I +Y K ++++PD G + RA+ A+ L
Sbjct: 215 LHSGQSMGYFDIPVDHVYCQPVILDYLASKSISSEDLVVVSPDVGGVARARAFAKKLSDA 274
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ +K R + + DV GK ++VDDII T GT++K A +L E GA+E++
Sbjct: 275 PLAIVDKRRHGHNVAEVMNLIGDVKGKVAVMVDDIIDTAGTIVKGAALLHEEGAREVYAC 334
Query: 236 ATHGVFAEGAIERVSKA-VNELAVTNTIP 263
TH VF+ AIER+S + E+ VTNT+P
Sbjct: 335 CTHAVFSPPAIERLSSGLLQEVIVTNTLP 363
>sp|Q42583|KPR2_ARATH RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2 (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE 2) (PRS II) >gi|2146772|pir||S71262
ribose-phosphate pyrophosphokinase (EC 2.7.6.1) II -
Arabidopsis thaliana (fragment)
>gi|1064885|emb|CAA63552.1| (X92974) phosphoribosyl
pyrophosphate synthetase II [Arabidopsis thaliana]
Length = 312
Score = 143 bits (358), Expect = 2e-33
Identities = 92/269 (34%), Positives = 148/269 (54%), Gaps = 10/269 (3%)
Query: 5 GSGAKHLEEEISRHGNLI--NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L +EI+ + L V IK+F DGE YV++ E RG + ++Q T P +ENL+
Sbjct: 7 GTANPALSQEIAWYMGLELGKVSIKRFADGEIYVQLKESVRGCDVFLVQPTCTPTNENLM 66
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDELYVFD 119
E L++ DA A KK+ VIPY Y+R DR T+ E I+ + + ++ D + D
Sbjct: 67 ELLIMVDACRRASAKKVTAVIPYFGYARADRKTQGRESIAAKLVANLITEAGADRVLACD 126
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAEVLG-L 175
+H+ +++ +F ++Y I +Y K ++++PD G + RA+ A+ L
Sbjct: 127 LHSGQSMGYFDIPVDHVYCQPVILDYLASKSISSEDLVVVSPDVGGVARARAFAKKLSDA 186
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ +K R + + DV GK ++VDDII T GT++K A +L E GA+E++
Sbjct: 187 PLAIVDKRRHGHNVAEVMNLIGDVKGKVAVMVDDIIDTAGTIVKGAALLHEEGAREVYAC 246
Query: 236 ATHGVFAEGAIERVSKA-VNELAVTNTIP 263
TH VF+ AIER+S + E+ VTNT+P
Sbjct: 247 CTHAVFSPPAIERLSSGLLQEVIVTNTLP 275
>dbj|BAB03785.1| (AP001507) phosphoribosyl pyrophosphate synthetase [Bacillus
halodurans]
Length = 316
Score = 143 bits (358), Expect = 2e-33
Identities = 86/258 (33%), Positives = 140/258 (53%), Gaps = 7/258 (2%)
Query: 26 IKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPY 83
+ +F DGE + + E RG + +IQST P +E+++E L++ DA+ A K + +VIPY
Sbjct: 37 VTRFSDGEVQINIEESIRGCDVFLIQSTAAPANEHIMELLIMIDAVKRASAKTINVVIPY 96
Query: 84 LAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAEAI 142
Y+RQDR + EPI+ + + +L + D+H + F + +
Sbjct: 97 YGYARQDRKARAREPITAKLVANLLETAGATRVLTLDLHATQIQGFFDIPVDQLMGVPIL 156
Query: 143 ANYFKDK-LGEGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNG 201
A +F+ K L + ++++PD G + RA+++A+ L + +K R P + + + G
Sbjct: 157 AEFFEKKGLDDVVVVSPDHGGVVRARKLADRLKAPIAIIDKRRPKPNVAEVMNIVGHIEG 216
Query: 202 KNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA-VNELAVTN 260
K +I+DDII T GT+ AAN L E GAKE++ TH V + AIER+ + + EL V N
Sbjct: 217 KTAIIIDDIIDTAGTITLAANALVEHGAKEVYACCTHPVLSGPAIERIKNSKIKELVVMN 276
Query: 261 TIPTEVSKISIVDYIVKL 278
TI E K ++D I L
Sbjct: 277 TIELEEEK--LIDKITTL 292
>pir||G82921 phosphoribosylpyrophosphate synthetase UU193 [imported] -
Ureaplasma urealyticum
>gi|6899158|gb|AAF30600.1|AE002119_5 (AE002119)
phosphoribosylpyrophosphate synthetase [Ureaplasma
urealyticum]
Length = 330
Score = 143 bits (357), Expect = 2e-33
Identities = 88/262 (33%), Positives = 144/262 (54%), Gaps = 16/262 (6%)
Query: 20 NLINVE-----IKKFPDGEKYV--RVLERGKEAIVIQSTYHPQDENLIEALLLGDALSEA 72
NL+ +E I KF DGE V +V RG+ I+IQST P +++L+E L+ D++ A
Sbjct: 24 NLLKIELSPIRIDKFADGELIVAPQVPVRGRRVIIIQSTSKPVNDSLMELLIAIDSIKRA 83
Query: 73 GFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYDELYVFDIHNPKTLEHFPG 131
K + +VIPY Y+RQDR K EPI+ R + KM+ + +DIH+ +T F
Sbjct: 84 SAKAISVVIPYYGYARQDRKAKPREPITARLVAKMIESAGATSVLTWDIHSLQTQGFFDI 143
Query: 132 IAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAEVLGLEYSHFEKERISPT 188
++ + ++ + I++PD G ++RA+ ++ G + +K R
Sbjct: 144 PFDSLEAVWVLMKHYFSAYKDSSNITIVSPDYGGVKRAREISIATGATLAIVDKRRSGKN 203
Query: 189 EVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIER 248
+V + V DV ++ +IVDD+I TGGT++ AA I+RE GAK I ++ATHG+F A +
Sbjct: 204 QVEINNVLGDVKDRDCVIVDDMIDTGGTILGAAKIVREKGAKSITIIATHGLFNNNARQH 263
Query: 249 VSKA-----VNELAVTNTIPTE 265
+A +N++ + +TI E
Sbjct: 264 FQQAIKDRIINKICIADTIENE 285
>pir||D72229 phosphoribosyl pyrophosphate synthetase - Thermotoga maritima
(strain MSB8) >gi|4982201|gb|AAD36695.1|AE001806_5
(AE001806) phosphoribosyl pyrophosphate synthetase
[Thermotoga maritima]
Length = 315
Score = 142 bits (355), Expect = 4e-33
Identities = 94/286 (32%), Positives = 157/286 (54%), Gaps = 15/286 (5%)
Query: 5 GSGAKHLEEEISRHGNLI--NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ + L E+I+ + NL + E+ +F DGE VR+ E RG + +IQ T P +ENL+
Sbjct: 12 GNANRPLAEKIANYLNLQLGDCEVGRFADGEINVRINETVRGHDIFLIQPTSPPVNENLM 71
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFD 119
E L++ DA A + +VIPY Y+RQDR K +PIS + + ++ + + D
Sbjct: 72 ELLIMIDAFKRASANTIAVVIPYYGYARQDRKAKGRDPISAKLVANLITVAGATRVLTVD 131
Query: 120 IHNPKTLEHFPGIAKNI--YPAEAIANYFKDKL--GEGLILAPDKGALERAKRVAEVLGL 175
+H + F N+ YP A ++ + E ++++PD G + RA+R+AE LG
Sbjct: 132 LHAEQIQGFFDIPVDNLWSYPVFAEELLKRENIVPEETVVVSPDVGGVRRARRMAERLGT 191
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ +K R S + + +V K V++ DDII T +++K A L+ GAK I
Sbjct: 192 SLAILDKRRPSDNVAEVVNIIGEVEDKVVIMFDDIIDTAHSIVKGAEALKNAGAKRIIAC 251
Query: 236 ATHGVFAEGAIERV-SKAVNELAVTNTI-----PTEVSKISIVDYI 275
ATHGVF++ A+ER+ + +++ + +T+TI P +V IS+ + I
Sbjct: 252 ATHGVFSDRALERIENSSIDTVYITDTIYHENLPEKVKVISVANLI 297
>pir||G83063 ribose-phosphate pyrophosphokinase PA4670 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9950925|gb|AAG08057.1|AE004880_13 (AE004880)
ribose-phosphate pyrophosphokinase [Pseudomonas
aeruginosa]
Length = 313
Score = 141 bits (351), Expect = 1e-32
Identities = 91/271 (33%), Positives = 146/271 (53%), Gaps = 8/271 (2%)
Query: 1 MFVIGSGAKHLEEEISR--HGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQD 56
M G+ L + R H L +V + KF DGE V + E RGK+ +IQ T P +
Sbjct: 5 MVFTGNANPDLARRVVRQLHIPLGDVSVGKFSDGEISVEINENVRGKDVFLIQPTCAPTN 64
Query: 57 ENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLGLY-YDE 114
+NL+E +++ DA + ++ VIPY Y+RQDR + IS + + ML + +
Sbjct: 65 DNLMELVVMADAFRRSSATRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGVNR 124
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGL-ILAPDKGALERAKRVAEVL 173
+ D+H + F NIY + + + +D+ E L I++PD G + RA+ VA+ L
Sbjct: 125 VLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFENLMIVSPDIGGVVRARAVAKSL 184
Query: 174 GLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIF 233
G++ + +K R + + + DV G+ ++VDD++ T GT+ AA L+E GA ++
Sbjct: 185 GVDLAIIDKRRPKANQSEVMHIIGDVEGRTCVLVDDMVDTAGTLGHAAKALKEHGAAKVI 244
Query: 234 VVATHGVFAEGAIERVSKAV-NELAVTNTIP 263
TH V + AIE + K+V +EL VTNTIP
Sbjct: 245 AYCTHPVLSGRAIENIEKSVLDELVVTNTIP 275
>sp|Q42581|KPR1_ARATH RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1 (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE 1) (PRS I) >gi|1076397|pir||S51270
ribose-phosphate pyrophosphokinase (EC 2.7.6.1) I -
Arabidopsis thaliana >gi|633140|emb|CAA58717.1| (X83764)
phosphoribosyl diphosphate synthetase [Arabidopsis
thaliana] >gi|3608149|gb|AAC36182.1| (AC005314)
phosphoribosyl pyrophosphate synthetase [Arabidopsis
thaliana]
Length = 352
Score = 140 bits (350), Expect = 1e-32
Identities = 86/252 (34%), Positives = 142/252 (56%), Gaps = 8/252 (3%)
Query: 20 NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKL 77
+L V IK+F DGE YV++ E RG + ++Q T P +ENL+E L++ DA A KK+
Sbjct: 64 DLGKVNIKRFADGEIYVQLQESVRGCDVYLVQPTCTPTNENLMELLIMVDACRRASAKKV 123
Query: 78 KIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDELYVFDIHNPKTLEHFPGIAKNI 136
VIPY Y+R DR T+ E I+ + + ++ D + D+H+ +++ +F ++
Sbjct: 124 TAVIPYFGYARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHV 183
Query: 137 YPAEAIANYFKDKL---GEGLILAPDKGALERAKRVAEVLG-LEYSHFEKERISPTEVRM 192
Y I +Y K + ++++PD G + RA+ A+ L + +K R +
Sbjct: 184 YCQPVILDYLASKSIPSEDLVVVSPDVGGVARARAFAKKLSDAPLAIVDKRRSGHNVAEV 243
Query: 193 KPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA 252
+ DV GK ++VDD+I T GT++K A +L + GA+E++ TH VF+ AIER+S
Sbjct: 244 MNLIGDVRGKVAIMVDDMIDTAGTIVKGAALLHQEGAREVYACCTHAVFSPPAIERLSGG 303
Query: 253 -VNELAVTNTIP 263
+ E+ VTNT+P
Sbjct: 304 LLQEVIVTNTLP 315
>pir||E71903 phosphoribosyl pyrophosphate synthetase - Helicobacter pylori
(strain J99) >gi|4155224|gb|AAD06246.1| (AE001499)
PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE [Helicobacter
pylori J99]
Length = 318
Score = 140 bits (350), Expect = 1e-32
Identities = 88/271 (32%), Positives = 146/271 (53%), Gaps = 9/271 (3%)
Query: 2 FVIGSGAKH--LEEEISRHGN--LINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
F I SG+ H +E+S+H L I KF DGE +++ E RGK+ +IQ T P
Sbjct: 13 FKIFSGSAHPAFGKEVSKHLGFPLSKAVIGKFSDGEINIQISESVRGKDIFIIQPTCVPV 72
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDE 114
++NL+E L++ DAL + + V+PY Y+RQDR PI+ + + ++ + +
Sbjct: 73 NDNLMELLVMVDALRRSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQEVGIER 132
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDK-LGEGLILAPDKGALERAKRVAEVL 173
+ D+H + F N+Y + +Y + K L +I +PD G + RA+ A +
Sbjct: 133 IITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSKALKNPIIASPDVGGVTRARYFANQM 192
Query: 174 GLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIF 233
GL+ +K R E + + ++V++VDD+I T GT+ KAA L+E GA +
Sbjct: 193 GLDLIIVDKRREKANESEVMNIIGSAKERDVILVDDMIDTAGTICKAALALKEQGATSVM 252
Query: 234 VVATHGVFAEGAIERVSK-AVNELAVTNTIP 263
+ TH V + AI+R+ + A++E+ VTN+IP
Sbjct: 253 ALGTHAVLSGNAIKRIKESALDEVVVTNSIP 283
>sp|P56184|KPRS_HELPY RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|7434657|pir||F64612 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Helicobacter pylori
(strain 26695) >gi|2313870|gb|AAD07793.1| (AE000587)
phosphoribosylpyrophosphate synthetase (prsA)
[Helicobacter pylori 26695]
Length = 318
Score = 140 bits (349), Expect = 2e-32
Identities = 88/271 (32%), Positives = 146/271 (53%), Gaps = 9/271 (3%)
Query: 2 FVIGSGAKH--LEEEISRHGN--LINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
F I SG+ H +E+S+H L I KF DGE +++ E RGK+ +IQ T P
Sbjct: 13 FKIFSGSAHPAFGKEVSKHLGFPLSKAVIGKFSDGEINIQISESVRGKDIFIIQPTCVPV 72
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDE 114
++NL+E L++ DAL + + V+PY Y+RQDR PI+ + + ++ + +
Sbjct: 73 NDNLMELLVMVDALRRSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQEVGIER 132
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDK-LGEGLILAPDKGALERAKRVAEVL 173
+ D+H + F N+Y + +Y + K L +I +PD G + RA+ A +
Sbjct: 133 IITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSKALKNPVIASPDVGGVTRARYFANQM 192
Query: 174 GLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIF 233
GL+ +K R E + + ++V++VDD+I T GT+ KAA L+E GA +
Sbjct: 193 GLDLIIVDKRREKANESEVMNIIGSAKERDVILVDDMIDTAGTICKAALALKEQGATSVM 252
Query: 234 VVATHGVFAEGAIERVSK-AVNELAVTNTIP 263
+ TH V + AI+R+ + A++E+ VTN+IP
Sbjct: 253 ALGTHAVLSGNAIKRIKESALDEVVVTNSIP 283
>gb|AAA62181.1| (M92842) prs [Listeria monocytogenes]
Length = 318
Score = 139 bits (346), Expect = 4e-32
Identities = 91/287 (31%), Positives = 157/287 (53%), Gaps = 18/287 (6%)
Query: 9 KHLEEEISRHGNLINVEIKK-----FPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIE 61
+ L EEI++ + +E+ K F DGE + + E RG VIQST +P ++NL+E
Sbjct: 19 RELAEEIAKE---VGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLME 75
Query: 62 ALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDI 120
L++ DAL A + IV+PY Y+RQDR + EPI+ + + ++ + D+
Sbjct: 76 LLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDM 135
Query: 121 HNPKTLEHFPGIAKNIYPAEAIANYFKDK-LGEGLIL-APDKGALERAKRVAEVLGLEYS 178
H P+ F ++ +++YF ++ LG+ L++ +PD G + RA+++A+ L +
Sbjct: 136 HAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIA 195
Query: 179 HFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATH 238
+K R P + + +V GK +I+DDII T GT+ AA LRE GA +++ +H
Sbjct: 196 IIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSH 255
Query: 239 GVFAEGAIERVSKA-VNELAVTNTI--PTE--VSKISIVDYIVKLGE 280
V + A++R+ ++ + +L VTN+I P E + K+ + LGE
Sbjct: 256 PVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGE 302
>gb|AAF15359.1|AF201954_1 (AF201954) phosphoribosylpyrophosphate synthetase [Plasmodium
falciparum]
Length = 323
Score = 139 bits (346), Expect = 4e-32
Identities = 99/300 (33%), Positives = 161/300 (53%), Gaps = 31/300 (10%)
Query: 8 AKHLEEEISRHGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLL 65
A HL + R V +K+F DGE ++ LE RGK+ +IQ T P +ENLIE LL+
Sbjct: 20 ADHLGTSLGR------VNLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLM 73
Query: 66 GDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYDELYVFDIHNPK 124
A KK+ VIPY Y+RQDR PIS + +M+ + D + D+H+ +
Sbjct: 74 ISTCRRASAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQ 133
Query: 125 TLEHF-PGIAKNIYPAEAIA-NYFKDK-LGEGLILAPDKGALERAKRVAEVLGLE----- 176
F P + + A+ I +YF K L + +I++PD G + RA++ + L
Sbjct: 134 IQGFFGPRVPVDNLEAQLIGLDYFTKKDLYKPVIVSPDAGGVYRARKFQDGLNHRGIGDC 193
Query: 177 -YSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ K R P E+ + +V +V+IVDD+I T GT+ +AA L++ GA+ +F
Sbjct: 194 GIAMLIKPRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAF 253
Query: 236 ATHGVFAEGAIERVSKA-VNELAVTNTIPT--------EVSKIS----IVDYIVKLGEKE 282
ATHG+F+ AI+R+ K+ + E+ VT+T+ + +++K+S + D I ++ +KE
Sbjct: 254 ATHGLFSGPAIDRIEKSPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKE 313
>sp|P44328|KPRS_HAEIN RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|1075154|pir||C64132 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Haemophilus influenzae
(strain Rd KW20) >gi|1574451|gb|AAC23253.1| (U32834)
phosphoribosylpyrophosphate synthetase (prsA)
[Haemophilus influenzae Rd]
Length = 315
Score = 138 bits (345), Expect = 6e-32
Identities = 86/264 (32%), Positives = 149/264 (55%), Gaps = 10/264 (3%)
Query: 8 AKHLEEEISRHGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLL 65
AK + E + + +L + + +F DGE V++ E RG + +IQST P ++NL+E +++
Sbjct: 16 AKRISERL--YISLGDATVARFSDGEIQVQINENVRGADVFIIQSTCAPTNDNLMELVVM 73
Query: 66 GDALSEAGFKKLKIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLGLY-YDELYVFDIHNP 123
DAL A ++ VIPY Y+RQDR + PI+ + + +L + D + D+H
Sbjct: 74 VDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIVGIDRVLTCDLHAE 133
Query: 124 KTLEHFPGIAKNIYPAEAIANYF--KDKLGEGLILAPDKGALERAKRVAEVLG-LEYSHF 180
+ F N++ + + + K L ++++PD G + RA+ VA++L + +
Sbjct: 134 QIQGFFDVPVDNVFGSPVLIHDILKKSDLKNPIVVSPDIGGVVRARAVAKLLNDTDMAII 193
Query: 181 EKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGV 240
+K R ++ + DV ++ ++VDD+I TGGT+ KAA L+E GAK +F ATH V
Sbjct: 194 DKRRPRANVAQVMHIIGDVADRDCILVDDMIDTGGTLCKAAEALKERGAKRVFAYATHAV 253
Query: 241 FAEGAIERV-SKAVNELAVTNTIP 263
F+ A + + S A++E+ VT+TIP
Sbjct: 254 FSGAAAKNLASDAIDEVVVTDTIP 277
>emb|CAB43599.1| (AJ006940) phosphoribosyl pyrophosphate synthase [Spinacia
oleracea]
Length = 336
Score = 137 bits (341), Expect = 2e-31
Identities = 87/269 (32%), Positives = 149/269 (55%), Gaps = 10/269 (3%)
Query: 5 GSGAKHLEEEISRHGNLI--NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L +EI+ + L ++IK+F DGE YV++ E RG + ++Q T P +ENL+
Sbjct: 31 GTANPALAQEIACYMGLQLGKIKIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLM 90
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDELYVFD 119
E L++ DA A K + VIPY Y+R DR T+ E I+ + + ++ + + D
Sbjct: 91 ELLIMIDACRRASAKNITAVIPYFGYARADRKTQGRESIAAKLVANLITEAGANRVLACD 150
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKL---GEGLILAPDKGALERAKRVAEVLG-L 175
+H+ +++ +F ++Y I +Y K + ++++PD G + RA+ A+ L
Sbjct: 151 LHSGQSMGYFDIPVDHVYGQPVILDYLASKTICSDDLVVVSPDVGGVARARAFAKKLSDA 210
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ +K R + + DV GK ++VDD+I T GT+ K A +L + GA+E++
Sbjct: 211 PLAIVDKRRHGHNVAEVMNLIGDVKGKVAVMVDDMIDTAGTISKGAALLHQEGAREVYAC 270
Query: 236 ATHGVFAEGAIERVSKAV-NELAVTNTIP 263
+TH VF+ AIER+S + E+ +TNTIP
Sbjct: 271 STHAVFSPPAIERLSSGLFQEVIITNTIP 299
>emb|CAB43600.1| (AJ006941) phosphoribosyl pyrophosphate synthase isozyme 2
[Spinacia oleracea]
Length = 395
Score = 137 bits (341), Expect = 2e-31
Identities = 83/248 (33%), Positives = 139/248 (55%), Gaps = 8/248 (3%)
Query: 24 VEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVI 81
V+IK+F DGE YV++ E RG + +IQ T P +ENL+E L++ DA A K + VI
Sbjct: 111 VKIKRFADGEIYVQLEESVRGCDVFIIQPTSPPANENLMELLIMIDACRRASAKNITAVI 170
Query: 82 PYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDELYVFDIHNPKTLEHFPGIAKNIYPAE 140
PY Y+R DR T+ E I+ + + ++ + + D+H+ +++ +F ++Y
Sbjct: 171 PYFGYARADRKTQGRESIAAKLVANLITEAGANRVLACDLHSGQSMGYFDIPVDHVYCQP 230
Query: 141 AIANYFKDK---LGEGLILAPDKGALERAKRVAEVLG-LEYSHFEKERISPTEVRMKPVD 196
I +Y K + ++++PD G + RA+ A+ L + +K R + + +
Sbjct: 231 VILDYLASKGIASSDLVVVSPDVGGVARARAFAKKLSDAPLAIVDKRRHAHNVAEVMNLI 290
Query: 197 VDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSK-AVNE 255
DV GK +++DD+I T GT+ K A +L E GA+E++ TH VF+ AIER+S E
Sbjct: 291 GDVKGKVAVMLDDMIDTAGTITKGAELLHEEGAREVYACCTHAVFSPPAIERLSSGCFQE 350
Query: 256 LAVTNTIP 263
+ +TNT+P
Sbjct: 351 VIITNTLP 358
>sp|Q59988|KPRS_SYNP7 RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|541316|pir||JN0886 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Synechococcus sp.
(strain PCC 7942) >gi|460896|gb|AAB29660.1|
phosphoribosylpyrophosphate synthetase, PRibPP
synthetase, ATP:ribose-5-phosphate
pyrophosphotransferase {EC 2.7.6.1} [Synechococcus,
PCC7942, Peptide, 331 aa] >gi|551633|dbj|BAA03638.1|
(D14994) phosphoribosylpyrophosphate synthetase
[Synechococcus sp.]
Length = 331
Score = 136 bits (340), Expect = 2e-31
Identities = 87/271 (32%), Positives = 151/271 (55%), Gaps = 15/271 (5%)
Query: 5 GSGAKHLEEEISRH-----GNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDE 57
GS L +E+SR+ G +I K+F DGE YV++ E RG + ++Q T P ++
Sbjct: 27 GSSNSALSQEVSRYLGIDLGPMIR---KRFADGELYVQIQESIRGCDVYLMQPTCWPVND 83
Query: 58 NLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELY 116
+L+E L++ DA A +++ V+PY Y+R DR T E I+ + + ++ + +
Sbjct: 84 HLMELLIMIDACRRASARQITAVLPYYGYARADRKTAGRESITAKLVANLITQAGANRVL 143
Query: 117 VFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDK-LGEGLILAPDKGALERAKRVAEVLG- 174
D+H+ + +F ++Y + + +Y + K L + ++++PD G + RA+ A+ L
Sbjct: 144 AMDLHSAQIQGYFDIPFDHVYGSPVLIDYLRSKNLADLVVVSPDVGGVARARAFAKKLDD 203
Query: 175 LEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFV 234
+ +K R + + V DV GK ++VDD+I T GT+ + A +LR+ GA +++
Sbjct: 204 APLAIIDKRRQAHNVAEVLNVIGDVQGKTAVLVDDMIDTAGTICEGARLLRKQGASQVYA 263
Query: 235 VATHGVFAEGAIERVSKA--VNELAVTNTIP 263
ATH VF+ AIER+S + E+ VTNTIP
Sbjct: 264 CATHAVFSPPAIERLSASGLFEEVIVTNTIP 294
>sp|O64888|KPR3_ARATH PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL
PYROPHOSPHATE SYNTHETASE) (PRS) >gi|7434660|pir||T02409
ribose-phosphate pyrophosphokinase (EC 2.7.6.1) F4I1.35
- Arabidopsis thaliana >gi|3341673|gb|AAC27455.1|
(AC003672) putative phosphoribosyl pyrophosphate
synthetase [Arabidopsis thaliana]
Length = 386
Score = 136 bits (339), Expect = 3e-31
Identities = 88/269 (32%), Positives = 146/269 (53%), Gaps = 10/269 (3%)
Query: 5 GSGAKHLEEEISRHGNLI--NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L +EIS + L ++IK+F DGE YV++ E RG + ++Q T P +ENL+
Sbjct: 83 GTANPILAQEISCYLGLDLGKIKIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLM 142
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFD 119
E L++ DA A K + VIPY Y+R DR T+ E I+ + + ++ D + D
Sbjct: 143 ELLVMIDACRRASAKTITAVIPYFGYARADRKTQGRESIAAKLVANLITQSGADRVLACD 202
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAEVLG-L 175
+H+ +++ +F ++Y I +Y K ++++PD G + RA+ A+ L
Sbjct: 203 LHSGQSMGYFDIPVDHVYGQPVILDYLASKAISSEDLVVVSPDVGGVARARAFAKKLSDA 262
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ +K R + + DV GK ++VDD+I T GT+ K A +L + GA+E++
Sbjct: 263 PLAIVDKRRHGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTISKGAALLHQEGAREVYAC 322
Query: 236 ATHGVFAEGAIERVSKAV-NELAVTNTIP 263
TH VF+ AI R+S + E+ +TNTIP
Sbjct: 323 TTHAVFSPPAISRLSSGLFQEVIITNTIP 351
>gi|6981418 phophoribosylpyrophosphate synthetase, subunit II [Rattus
norvegicus] >gi|125584|sp|P09330|KPR2_RAT
RIBOSE-PHOSPHATE PYROPHOSPHOKINASE II (PHOSPHORIBOSYL
PYROPHOSPHATE SYNTHETASE II) >gi|66945|pir||KIRTR2
ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
catalytic chain II - rat >gi|56979|emb|CAA34556.1|
(X16555) ribose-phosphate pyrophosphokinase subunit II
(AA 1-318) [Rattus norvegicus] >gi|206434|gb|AAA41964.1|
(M17259) phosphoribosyl pyrophosphate synthetase II
[Rattus norvegicus]
Length = 318
Score = 136 bits (338), Expect = 4e-31
Identities = 92/295 (31%), Positives = 155/295 (52%), Gaps = 18/295 (6%)
Query: 3 VIGSGAKHLEEEISRHGNLINVEI-----KKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
V+ SG+ H ++ R + + +E+ KKF + E V + E RG++ +IQS
Sbjct: 5 VLFSGSSH-QDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEI 63
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDE 114
++NL+E L++ +A A ++ VIP Y+RQD+ K PIS + + ML + D
Sbjct: 64 NDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAE 171
+ D+H + F N+Y A+ + ++ + E +I++PD G +R +A+
Sbjct: 124 IITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIAD 183
Query: 172 VLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKE 231
L +E++ KER EV + DV + ++VDD+ T GT+ AA+ L GA +
Sbjct: 184 RLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATK 243
Query: 232 IFVVATHGVFAEGAIERVSKAVNE-LAVTNTIPTE-----VSKISIVDYIVKLGE 280
++ + THG+F+ AI R++ A E + VTNTIP E SKI ++D + L E
Sbjct: 244 VYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAE 298
>gb|AAA41961.1| (M29393) phosphoribosylphosphate synthetase (PRPS2) precursor
[Rattus norvegicus]
Length = 318
Score = 136 bits (338), Expect = 4e-31
Identities = 92/295 (31%), Positives = 155/295 (52%), Gaps = 18/295 (6%)
Query: 3 VIGSGAKHLEEEISRHGNLINVEI-----KKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
V+ SG+ H ++ R + + +E+ KKF + E V + E RG++ +IQS
Sbjct: 5 VLFSGSSH-QDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEI 63
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDE 114
++NL+E L++ +A A ++ VIP Y+RQD+ K PIS + + ML + D
Sbjct: 64 NDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAE 171
+ D+H + F N+Y A+ + ++ + E +I++PD G +R +A+
Sbjct: 124 IITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIAD 183
Query: 172 VLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKE 231
L +E++ KER EV + DV + ++VDD+ T GT+ AA+ L GA +
Sbjct: 184 RLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADNLLSAGATK 243
Query: 232 IFVVATHGVFAEGAIERVSKAVNE-LAVTNTIPTE-----VSKISIVDYIVKLGE 280
++ + THG+F+ AI R++ A E + VTNTIP E SKI ++D + L E
Sbjct: 244 VYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAE 298
>gi|4506129 phosphoribosyl pyrophosphate synthetase 2 [Homo sapiens]
>gi|125583|sp|P11908|KPR2_HUMAN RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE II (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE II) (PPRIBP) (PRS-II) >gi|66944|pir||KIHUR2
ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
catalytic chain II - human >gi|35700|emb|CAA68785.1|
(Y00971) PPRibP synthetase (AA 1 - 318) [Homo sapiens]
Length = 318
Score = 135 bits (337), Expect = 5e-31
Identities = 91/295 (30%), Positives = 155/295 (51%), Gaps = 18/295 (6%)
Query: 3 VIGSGAKHLEEEISRHGNLINVEI-----KKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
V+ SG+ H ++ R + + +E+ KKF + E V + E RG++ +IQS
Sbjct: 5 VLFSGSSH-QDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEI 63
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDE 114
++NL+E L++ +A A ++ VIP Y+RQD+ K PIS + + ML + D
Sbjct: 64 NDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 123
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAE 171
+ D+H + F N+Y A+ + ++ + E +I++PD G +R +A+
Sbjct: 124 IITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIAD 183
Query: 172 VLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKE 231
L +E++ KER EV + DV + ++VDD+ T GT+ AA+ L GA +
Sbjct: 184 RLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATK 243
Query: 232 IFVVATHGVFAEGAIERVSKAVNE-LAVTNTIPTE-----VSKISIVDYIVKLGE 280
++ + THG+F+ AI R++ A E + VTNTIP E +KI ++D + L E
Sbjct: 244 VYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAE 298
>gi|11421042 phosphoribosyl pyrophosphate synthetase 2 [Homo sapiens]
Length = 338
Score = 135 bits (337), Expect = 5e-31
Identities = 91/295 (30%), Positives = 155/295 (51%), Gaps = 18/295 (6%)
Query: 3 VIGSGAKHLEEEISRHGNLINVEI-----KKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ 55
V+ SG+ H ++ R + + +E+ KKF + E V + E RG++ +IQS
Sbjct: 25 VLFSGSSH-QDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEI 83
Query: 56 DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDE 114
++NL+E L++ +A A ++ VIP Y+RQD+ K PIS + + ML + D
Sbjct: 84 NDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADH 143
Query: 115 LYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAE 171
+ D+H + F N+Y A+ + ++ + E +I++PD G +R +A+
Sbjct: 144 IITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIAD 203
Query: 172 VLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKE 231
L +E++ KER EV + DV + ++VDD+ T GT+ AA+ L GA +
Sbjct: 204 RLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATK 263
Query: 232 IFVVATHGVFAEGAIERVSKAVNE-LAVTNTIPTE-----VSKISIVDYIVKLGE 280
++ + THG+F+ AI R++ A E + VTNTIP E +KI ++D + L E
Sbjct: 264 VYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAE 318
>gb|AAA98523.1| (U54642) phosphoribosylpyrophosphate synthetase [Plasmodium
falciparum]
Length = 322
Score = 135 bits (336), Expect = 6e-31
Identities = 99/301 (32%), Positives = 162/301 (52%), Gaps = 34/301 (11%)
Query: 8 AKHLEEEISRHGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLL 65
A HL + R V +K+F DGE ++ LE RGK+ +IQ T P +ENLIE LL+
Sbjct: 20 ADHLGTSLGR------VNLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLM 73
Query: 66 GDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYDELYVFDIHNPK 124
A KK+ VIPY Y+RQDR PIS + +M+ + D + D+H+ +
Sbjct: 74 ISTCRRASAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQ 133
Query: 125 TLEHF-PGIAKNIYPAEAIA-NYFKDK-LGEGLILAPDKGALERAKRVAEVLGLEYSHFE 181
F P + + A+ I +YF K L + +I++PD G + RA++ + GL +
Sbjct: 134 IQGFFGPRVPVDNLEAQLIGLDYFTKKDLYKPVIVSPDAGGVYRARKFQD--GLNHRGIG 191
Query: 182 KERIS-------PTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFV 234
I+ P E+ + +V +V+IVDD+I T GT+ +AA L++ GA+ +F
Sbjct: 192 DCGIAMLINKNKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFA 251
Query: 235 VATHGVFAEGAIERVSKA-VNELAVTNTIPT--------EVSKIS----IVDYIVKLGEK 281
ATHG+F+ AI+R+ K+ + E+ VT+T+ + +++K+S + D I ++ +K
Sbjct: 252 FATHGLFSGPAIDRIEKSPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQK 311
Query: 282 E 282
E
Sbjct: 312 E 312
>gb|AAF50223.1| (AE003551) CG6767 gene product [alt 1] [Drosophila melanogaster]
Length = 318
Score = 135 bits (336), Expect = 6e-31
Identities = 92/291 (31%), Positives = 150/291 (50%), Gaps = 16/291 (5%)
Query: 6 SGAKH---LEEEISRHG-NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENL 59
SG H + + R G +L V KKF + E V + E RG++ ++QS ++NL
Sbjct: 8 SGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNL 67
Query: 60 IEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVF 118
+E L++ +A A ++ VIP Y+RQD+ K PIS + + ML + D +
Sbjct: 68 MELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITM 127
Query: 119 DIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGE---GLILAPDKGALERAKRVAEVLGL 175
D+H + F N+Y A+ + K+ + E +I++PD G +R +A+ L +
Sbjct: 128 DLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIVSPDAGGAKRVTSIADRLNV 187
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
E++ KER EV + DV K ++VDD+ T GT++ AA+ L E GA +++ +
Sbjct: 188 EFALIHKERKKANEVASMVLVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAI 247
Query: 236 ATHGVFAEGAIERVSKAVNE-LAVTNTIP-----TEVSKISIVDYIVKLGE 280
THG+F+ AI R++ A E + VTNTIP + KI +D + E
Sbjct: 248 LTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCIDVSMMFAE 298
>pir||S73408 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) prs - Mycoplasma
pneumoniae (strain ATCC 29342)
>gi|1673736|gb|AAB95730.1| (AE000010)
phosphoribosylpyrophosphate synthetase [Mycoplasma
pneumoniae]
Length = 388
Score = 134 bits (335), Expect = 8e-31
Identities = 88/246 (35%), Positives = 134/246 (53%), Gaps = 10/246 (4%)
Query: 28 KFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLA 85
+F DGE Y+R E R K+ + QST P +++L+E L+ DAL K + ++PY
Sbjct: 96 EFADGETYIRFEESVRNKDVFIFQSTCAPVNDSLMELLIAIDALKRGSAKSITAILPYYG 155
Query: 86 YSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAEAIAN 144
Y+RQDR T EPI+ + + +L + + DIH+ +T F +
Sbjct: 156 YARQDRKTMGREPITSKLVADLLTTAGVSRVALTDIHSDQTQGFFNIPVDTLRTYHVFLT 215
Query: 145 YFKDKLGEG--LILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNGK 202
+ LG+ ++++PD G ++RA+ +A L L + +K R + V +V K
Sbjct: 216 RTVELLGKKDLVVVSPDYGGVKRARLIATSLELPLAIIDKRRPAHNVAESINVLGEVANK 275
Query: 203 NVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKAVNE-----LA 257
N LIVDD+I TGGT+I AA +LRE AK++ V+ATHG+F A +R KA NE L
Sbjct: 276 NCLIVDDMIDTGGTVIAAAKLLREHHAKKVCVMATHGLFNGEAPQRFQKAFNEGLVDYLF 335
Query: 258 VTNTIP 263
V+N+IP
Sbjct: 336 VSNSIP 341
>sp|P75044|KPRS_MYCPN RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE)
Length = 300
Score = 134 bits (335), Expect = 8e-31
Identities = 88/246 (35%), Positives = 134/246 (53%), Gaps = 10/246 (4%)
Query: 28 KFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLA 85
+F DGE Y+R E R K+ + QST P +++L+E L+ DAL K + ++PY
Sbjct: 8 EFADGETYIRFEESVRNKDVFIFQSTCAPVNDSLMELLIAIDALKRGSAKSITAILPYYG 67
Query: 86 YSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAEAIAN 144
Y+RQDR T EPI+ + + +L + + DIH+ +T F +
Sbjct: 68 YARQDRKTMGREPITSKLVADLLTTAGVSRVALTDIHSDQTQGFFNIPVDTLRTYHVFLT 127
Query: 145 YFKDKLGEG--LILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNGK 202
+ LG+ ++++PD G ++RA+ +A L L + +K R + V +V K
Sbjct: 128 RTVELLGKKDLVVVSPDYGGVKRARLIATSLELPLAIIDKRRPAHNVAESINVLGEVANK 187
Query: 203 NVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKAVNE-----LA 257
N LIVDD+I TGGT+I AA +LRE AK++ V+ATHG+F A +R KA NE L
Sbjct: 188 NCLIVDDMIDTGGTVIAAAKLLREHHAKKVCVMATHGLFNGEAPQRFQKAFNEGLVDYLF 247
Query: 258 VTNTIP 263
V+N+IP
Sbjct: 248 VSNSIP 253
>emb|CAB95916.1| (AL359989) ribose-phosphate pyrophosphokinase [Streptomyces
coelicolor A3(2)]
Length = 324
Score = 134 bits (334), Expect = 1e-30
Identities = 93/288 (32%), Positives = 154/288 (53%), Gaps = 18/288 (6%)
Query: 1 MFVIGSGAKHLEEEISRHGNLINVEIKKFP--DGEKYVRVLE--RGKEAIVIQSTYHPQD 56
MF G L EE+++ + V K F +GE YVR E RG + +IQS P +
Sbjct: 13 MFFSGRAHPELAEEVAQQLGVGVVPTKAFDFANGEIYVRYQESARGADCFLIQSHTAPIN 72
Query: 57 ENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAI---MKMLGLYYD 113
+ ++E L++ DAL A + + +++P+ Y+RQD+ + EPIS R I MK G D
Sbjct: 73 KWVMEQLIMIDALKRASARSITVIVPFYGYARQDKKHRGREPISARLIADLMKTAGA--D 130
Query: 114 ELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG--LILAPDKGALERAKRVAE 171
+ D+H + F G +++ +A+Y K+ +++PD G + A R +
Sbjct: 131 RILAVDLHTDQIQGFFDGPVDHLFALPLLADYVGAKVDRSKLTVVSPDAGRVRVADRWCD 190
Query: 172 VLG--LEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGA 229
LG L H +++ +V + V DV G+ ++VDD+I TGGT+ AA+ L GA
Sbjct: 191 RLGAPLAIVHKRRDKDVANQVTVHEVVGDVKGRICVLVDDMIDTGGTICAAADALFAHGA 250
Query: 230 KEIFVVATHGVFAEGAIERVSKA-VNELAVTNTIPT----EVSKISIV 272
+++ V ATHGV + A +R+ + V+E TNT+P+ E+ KI+++
Sbjct: 251 EDVIVTATHGVLSGPAADRLKNSKVSEFVFTNTLPSASELELDKITVL 298
>gi|4506127 phosphoribosyl pyrophosphate synthetase 1 [Homo sapiens]
>gi|8394053|ref|NP_058939.1| phosphoribosyl
pyrophosphate synthetase 1 [Rattus norvegicus]
>gi|10946854|ref|NP_067438.1| phosphoribosyl
pyrophosphate synthetase 1 [Mus musculus]
>gi|125582|sp|P09329|KPR1_HUMAN RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE I (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE I) (PPRIBP) (PRS-I) >gi|66946|pir||KIHUR1
ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
catalytic chain I - human >gi|66947|pir||KIRTR1
ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
catalytic chain I - rat >gi|35702|emb|CAA33386.1|
(X15331) phosphoribosylpyrophosphate synthetase (AA
1-319) [Homo sapiens] >gi|56977|emb|CAA34555.1| (X16554)
ribose-phosphate pyrophosphokinase subunit I (AA 1-318)
[Rattus norvegicus] >gi|206424|gb|AAA41959.1| (M31084)
phosphoribosylpyrophosphate synthetase [Rattus
norvegicus] >gi|206426|gb|AAA41960.1| (M29392)
phosphoribosylpyrophosphate synthetase (PRPS1) precursor
[Rattus norvegicus] >gi|206432|gb|AAA41963.1| (M17258)
phosphoribosyl pyrophosphate synthetase I [Rattus
norvegicus] >gi|220020|dbj|BAA00733.1| (D00860)
phosphoribosyl pyrophosphate synthetase subunit I [Homo
sapiens] >gi|5931551|dbj|BAA84686.1| (AB025048) Sid6061p
[Mus musculus]
Length = 318
Score = 133 bits (332), Expect = 2e-30
Identities = 92/290 (31%), Positives = 151/290 (51%), Gaps = 14/290 (4%)
Query: 5 GSGAKHLEEEIS-RHG-NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
GS + L ++I+ R G L V KKF + E V + E RG++ ++QS ++NL+
Sbjct: 9 GSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLM 68
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFD 119
E L++ +A A ++ VIP Y+RQD+ K PIS + + ML + D + D
Sbjct: 69 ELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMD 128
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAEVLGLE 176
+H + F N+Y A+ + ++ + E I++PD G +R +A+ L ++
Sbjct: 129 LHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVD 188
Query: 177 YSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVA 236
++ KER EV + DV + ++VDD+ T GT+ AA+ L GA ++ +
Sbjct: 189 FALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAIL 248
Query: 237 THGVFAEGAIERVSKAVNE-LAVTNTIPTE-----VSKISIVDYIVKLGE 280
THG+F+ AI R++ A E + VTNTIP E SKI ++D + L E
Sbjct: 249 THGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAE 298
>pir||D70622 probable prsA protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1870011|emb|CAB06862.1| (Z92539) prsA [Mycobacterium
tuberculosis]
Length = 326
Score = 133 bits (332), Expect = 2e-30
Identities = 85/274 (31%), Positives = 147/274 (53%), Gaps = 11/274 (4%)
Query: 1 MFVIGSGAKHLEEEISRH--GNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQD 56
M G L E++++ ++ + + ++F +GE +VR E RG +A V+QS P +
Sbjct: 13 MLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVN 72
Query: 57 ENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDEL 115
L+E L++ DAL K++ V+P+ Y+RQD+ + EPIS R I +L D +
Sbjct: 73 RWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRI 132
Query: 116 YVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG--LILAPDKGALERAKRVAEVL 173
D+H + F G ++ + Y +D +G ++++PD G + A++ A+ L
Sbjct: 133 VTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSGRVRIAEKWADAL 192
Query: 174 G---LEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAK 230
G L + H ++ P +V V DV G+ +++DD+I TGGT+ A +L GA
Sbjct: 193 GGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLHNDGAG 252
Query: 231 EIFVVATHGVFAEGAIERV-SKAVNELAVTNTIP 263
++ + ATHGV ++ A +R+ S E+ VTNT+P
Sbjct: 253 DVIIAATHGVLSDPAAQRLASCGAREVIVTNTLP 286
>pir||F82109 ribose-phosphate pyrophosphokinase VC2183 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9656737|gb|AAF95328.1| (AE004289) ribose-phosphate
pyrophosphokinase [Vibrio cholerae]
Length = 314
Score = 133 bits (331), Expect = 3e-30
Identities = 81/250 (32%), Positives = 140/250 (55%), Gaps = 7/250 (2%)
Query: 20 NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKL 77
+L + + +F DGE V++ E RG + +IQST P ++NL+E +++ DA+ A ++
Sbjct: 26 SLGDATVSRFSDGEVAVQINENVRGSDVFIIQSTCAPTNDNLMELVVMIDAMRRASAGRI 85
Query: 78 KIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLG-LYYDELYVFDIHNPKTLEHFPGIAKN 135
VIPY Y+RQDR + PI+ + + L + D + D+H + F N
Sbjct: 86 TAVIPYFGYARQDRRVRSARVPITAKVVADFLSNVGVDRVLTIDLHAEQIQGFFDVPVDN 145
Query: 136 IYPAEAIANYFKDK-LGEGLILAPDKGALERAKRVAEVLG-LEYSHFEKERISPTEVRMK 193
I+ + K + L + ++++PD G + RA+ A+ LG ++ + +K R +
Sbjct: 146 IFGTPVLLEDMKARNLEDPVVVSPDLGGVVRARATAKALGDIDIAIVDKRRPRANVSEVM 205
Query: 194 PVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKAV 253
+ DV G++ +IVDD+I TGGT+ KAA L+E GAK +F ATH VF+ A + + +V
Sbjct: 206 NLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERGAKRVFAYATHAVFSGNAAKNIKNSV 265
Query: 254 -NELAVTNTI 262
+++ VT++I
Sbjct: 266 LDQVIVTDSI 275
>gb|AAA24431.1| (M13174) phosphoribosylpyrophosphate synthetase (gtg start codon;
EC 2.7.6.1) [Escherichia coli]
Length = 315
Score = 130 bits (324), Expect = 2e-29
Identities = 81/268 (30%), Positives = 148/268 (55%), Gaps = 9/268 (3%)
Query: 5 GSGAKHLEEEISR--HGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L + I+ + +L + + +F DGE V++ E RG + +IQST P ++NL+
Sbjct: 9 GNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLM 68
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLG-LYYDELYVF 118
E +++ DAL A ++ VIPY Y+RQDR + PI+ + + L + D + +
Sbjct: 69 ELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLIV 128
Query: 119 DIHNPKTLEHFPGIAKNIYPAEAIA-NYFKDKLGEGLILAPDKGALERAKRVAEVLG-LE 176
D+H + F N++ + + + + L ++++PD G + RA+ +A++L +
Sbjct: 129 DLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTD 188
Query: 177 YSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVA 236
+ +K R ++ + DV G++ ++VDD+I TGGT+ KAA L+E GAK +F A
Sbjct: 189 MAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYA 248
Query: 237 THGVFAEGAIERV-SKAVNELAVTNTIP 263
TH +F+ A + + ++E+ V +TIP
Sbjct: 249 THPIFSGNAANNLRNSVIDEVVVCDTIP 276
>sp|P15849|KPRS_SALTY RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|66949|pir||KIEBRT ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Salmonella typhimurium
>gi|154285|gb|AAA27196.1| (M19488)
phosphoribosylpyrophosphate synthetase (EC 2.7.6.1)
[Salmonella typhimurium]
Length = 315
Score = 129 bits (321), Expect = 4e-29
Identities = 81/268 (30%), Positives = 147/268 (54%), Gaps = 9/268 (3%)
Query: 5 GSGAKHLEEEISR--HGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L + I+ + +L + + +F DGE V++ E RG + +IQST P ++NL+
Sbjct: 9 GNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLM 68
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLG-LYYDELYVF 118
E +++ DAL A ++ VIPY Y+RQDR + PI+ + + L + D +
Sbjct: 69 ELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTV 128
Query: 119 DIHNPKTLEHFPGIAKNIYPAEAIA-NYFKDKLGEGLILAPDKGALERAKRVAEVLG-LE 176
D+H + F N++ + + + + L ++++PD G + RA+ +A++L +
Sbjct: 129 DLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTD 188
Query: 177 YSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVA 236
+ +K R ++ + DV G++ ++VDD+I TGGT+ KAA L+E GAK +F A
Sbjct: 189 MAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYA 248
Query: 237 THGVFAEGAIERV-SKAVNELAVTNTIP 263
TH +F+ A + + ++E+ V +TIP
Sbjct: 249 THPIFSGNAANNLRNSVIDEVVVCDTIP 276
>sp|P08330|KPRS_ECOLI RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|7428066|pir||KIECRY ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) [validated] - Escherichia
coli >gi|1787458|gb|AAC74291.1| (AE000219)
phosphoribosylpyrophosphate synthetase [Escherichia coli
K12] >gi|4062790|dbj|BAA36065.1| (D90756)
Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
(phosphoribosyl pyrophosphate synthetase). [Escherichia
coli]
Length = 315
Score = 129 bits (321), Expect = 4e-29
Identities = 81/268 (30%), Positives = 147/268 (54%), Gaps = 9/268 (3%)
Query: 5 GSGAKHLEEEISR--HGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L + I+ + +L + + +F DGE V++ E RG + +IQST P ++NL+
Sbjct: 9 GNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLM 68
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLG-LYYDELYVF 118
E +++ DAL A ++ VIPY Y+RQDR + PI+ + + L + D +
Sbjct: 69 ELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTV 128
Query: 119 DIHNPKTLEHFPGIAKNIYPAEAIA-NYFKDKLGEGLILAPDKGALERAKRVAEVLG-LE 176
D+H + F N++ + + + + L ++++PD G + RA+ +A++L +
Sbjct: 129 DLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTD 188
Query: 177 YSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVA 236
+ +K R ++ + DV G++ ++VDD+I TGGT+ KAA L+E GAK +F A
Sbjct: 189 MAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYA 248
Query: 237 THGVFAEGAIERV-SKAVNELAVTNTIP 263
TH +F+ A + + ++E+ V +TIP
Sbjct: 249 THPIFSGNAANNLRNSVIDEVVVCDTIP 276
>sp|P47304|KPRS_MYCGE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|1361789|pir||D64206 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - Mycoplasma genitalium
>gi|1045732|gb|AAC71275.1| (U39685) ribose-phosphate
pyrophosphokinase (prs) [Mycoplasma genitalium]
Length = 297
Score = 128 bits (319), Expect = 6e-29
Identities = 91/265 (34%), Positives = 145/265 (54%), Gaps = 26/265 (9%)
Query: 29 FPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAY 86
F DGE Y+R E R K+ + QST +++L+E L+ DAL K + ++PY Y
Sbjct: 6 FADGETYIRFDESVRNKDIYIFQSTCPNVNDSLMELLIAIDALKRGSAKSITAILPYYGY 65
Query: 87 SRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANY 145
+RQDR TK EPI+ + I ML + + + DIH+ +T F P +++ Y
Sbjct: 66 ARQDRKTKGREPITSKLIADMLTKAGANRVVLTDIHSDQTQGFFD------IPVDSLRTY 119
Query: 146 ----FK--DKLGEG--LILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDV 197
F+ + LG+ ++++PD G ++RA+ +A L L + +K R S V
Sbjct: 120 HIFLFRVIELLGKKDLVVVSPDYGGVKRARLIANTLELPLAIIDKRRPSHNVAESINVLG 179
Query: 198 DVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKAVNE-- 255
+V KN LIVDD+I TGGT+I AA +L++ AK++ V+ATHG+F A ++ +A ++
Sbjct: 180 EVKNKNCLIVDDMIDTGGTVIAAAKLLQKEQAKKVCVMATHGLFNNDAEQKFMEAFDQKL 239
Query: 256 ---LAVTNTIP----TEVSKISIVD 273
L V+N+IP V + +VD
Sbjct: 240 IDFLFVSNSIPQYKFKAVKQFEVVD 264
>pir||B75393 ribose-phosphate pyrophosphokinase - Deinococcus radiodurans
(strain R1) >gi|6459216|gb|AAF11025.1|AE001990_2
(AE001990) ribose-phosphate pyrophosphokinase
[Deinococcus radiodurans]
Length = 332
Score = 128 bits (319), Expect = 6e-29
Identities = 74/234 (31%), Positives = 132/234 (55%), Gaps = 5/234 (2%)
Query: 41 RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPIS 100
R + ++Q+ P + ++E +L+ DA A ++ VIPY +Y+R D+ I+
Sbjct: 65 REGDVFIVQTFSTPVSDAIMELMLMIDAAKSASAGRVTAVIPYYSYARSDKKDSPRISIA 124
Query: 101 VRAIMKMLG-LYYDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGE---GLIL 156
R + +L D + +H+P+ F ++ ++ +FK + + G++L
Sbjct: 125 GRLVADLLQEAGADRVLTMTLHSPQVHGFFKVPVDHLSADVVLSQHFKKCVPDAHNGVVL 184
Query: 157 APDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGT 216
APD G+++RA ++A L + +KER+S TEVR + + DV+GK V IVDD IST G+
Sbjct: 185 APDAGSIKRASQIARRLDSGLAMIDKERLSDTEVRPRALIGDVDGKTVFIVDDEISTAGS 244
Query: 217 MIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA-VNELAVTNTIPTEVSKI 269
+++ +I R +GAK+++V THGV++ AIER++ V ++A NT+ K+
Sbjct: 245 LVETVSIARSMGAKDVYVAVTHGVYSGPAIERIAALDVTQVASCNTVLVPQDKL 298
>gi|6320946 ribose-phosphate pyrophosphokinase 2; Prs2p [Saccharomyces
cerevisiae] >gi|585369|sp|P38620|KPR2_YEAST
RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2 (PHOSPHORIBOSYL
PYROPHOSPHATE SYNTHETASE 2) >gi|480738|pir||S37225
ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PRS2 -
yeast (Saccharomyces cerevisiae)
>gi|403028|emb|CAA52969.1| (X75075) ribose-phosphate
pyrophosphokinase [Saccharomyces cerevisiae]
>gi|587541|emb|CAA52436.1| (X74414) ribose-phosphate
pyrophosphokinase [Saccharomyces cerevisiae]
>gi|603337|gb|AAB64654.1| (U18839) Prs2p:
ribose-phosphate pyrophosphokinase [Saccharomyces
cerevisiae]
Length = 318
Score = 127 bits (317), Expect = 1e-28
Identities = 78/263 (29%), Positives = 140/263 (52%), Gaps = 9/263 (3%)
Query: 21 LINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTY--HPQDENLIEALLLGDALSEAGFKK 76
L V + ++ + E V + E R ++ +IQ+ Y H ++ L+E L+L A A ++
Sbjct: 29 LSKVGVYQYSNKETSVTIGESIRDEDVYIIQTGYGEHEINDFLMELLILIHACKTASVRR 88
Query: 77 LKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKN 135
+ VIP Y+RQD+ K PI+ + I +L D + D+H + F N
Sbjct: 89 ITAVIPNFPYARQDKKDKSRAPITAKLIANLLETAGCDHVITMDLHASQIQGFFHIPVDN 148
Query: 136 IYPAEAIANYFKDK--LGEGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMK 193
+Y ++ NY + K ++++PD G +R +A+ L + ++ KER EV
Sbjct: 149 LYGEPSVLNYIRTKTDFNNAILVSPDAGGAKRVASLADKLDMNFALIHKERQKANEVSRM 208
Query: 194 PVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIER-VSKA 252
+ DV GK+ L++DD+ T GT++KA + L + GAKE+ + THG+F+ A E+ ++
Sbjct: 209 LLVGDVAGKSCLLIDDMADTCGTLVKACDTLMDHGAKEVIAIVTHGIFSGSAREKLINSR 268
Query: 253 VNELAVTNTIPTEVSKISIVDYI 275
++ + TNT+P ++ + IVD +
Sbjct: 269 LSRIVCTNTVPVDLD-LDIVDQV 290
>sp|P21108|KPR3_HUMAN RIBOSE-PHOSPHATE PYROPHOSPHOKINASE III (PHOSPHORIBOSYL
PYROPHOSPHATE SYNTHETASE III) (PRS-III)
>gi|66948|pir||KIHUR3 ribose-phosphate pyrophosphokinase
(EC 2.7.6.1) catalytic chain III - human
>gi|190522|gb|AAB59463.1| (M57423)
phosphoribosylpyrophosphate synthetase subunit III [Homo
sapiens]
Length = 318
Score = 127 bits (316), Expect = 1e-28
Identities = 89/290 (30%), Positives = 151/290 (51%), Gaps = 14/290 (4%)
Query: 5 GSGAKHLEEEIS-RHG-NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
GS + L ++I+ R G L V KKF + E V + E RG++ ++QS +++L+
Sbjct: 9 GSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGCGEINDSLM 68
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFD 119
E L++ +A A ++ VIP Y+RQD+ K PIS + + ML + D + D
Sbjct: 69 ELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAGADHIITMD 128
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEG---LILAPDKGALERAKRVAEVLGLE 176
+H + F N+Y + + ++ + E +I++PD G +R +A+ L ++
Sbjct: 129 LHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLNVD 188
Query: 177 YSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVA 236
++ KER EV + DVN + ++VDD+ T T+ AA+ L GA ++ +
Sbjct: 189 FALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAGATRVYAIL 248
Query: 237 THGVFAEGAIERVSKAVNE-LAVTNTIPTE-----VSKISIVDYIVKLGE 280
THG+F+ AI R++ A E + VTNTIP + SKI ++D + L E
Sbjct: 249 THGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAE 298
>pir||T16763 hypothetical protein R151.2 - Caenorhabditis elegans
>gi|459000|gb|AAA50652.1| (U00036) similar to
ribose-phosphate pyrophosphokinase [Caenorhabditis
elegans]
Length = 377
Score = 127 bits (316), Expect = 1e-28
Identities = 87/284 (30%), Positives = 145/284 (50%), Gaps = 18/284 (6%)
Query: 9 KHLEEEISRHGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLG 66
+ L+ E+S+ +KKF + E V + E RG++ +IQS ++NL+E L++
Sbjct: 79 ERLQLEVSK------ASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMI 132
Query: 67 DALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKT 125
+A A ++ VIP Y+RQD+ K PIS + + ML + D + D+H +
Sbjct: 133 NACKIASSCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQI 192
Query: 126 LEHFPGIAKNIYPAEAIANYFKDKLGE---GLILAPDKGALERAKRVAEVLGLEYSHFEK 182
F N+Y AI Y K+ + +I++PD G +R +A+ L ++++ K
Sbjct: 193 QGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHK 252
Query: 183 ERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFA 242
E EV + V GK ++VDD+ T GT+ AA+ L E GA +++ HG+F+
Sbjct: 253 ESKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHGIFS 312
Query: 243 EGAIERVSKAVNE-LAVTNTIPTE-----VSKISIVDYIVKLGE 280
A+ R++ + E + VTNTIP + SKI +D + L E
Sbjct: 313 GPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAE 356
>dbj|BAB12886.1| (AP001118) ribose-phosphate pyrophosphokinase [Buchnera sp. APS]
Length = 312
Score = 127 bits (316), Expect = 1e-28
Identities = 78/251 (31%), Positives = 140/251 (55%), Gaps = 7/251 (2%)
Query: 20 NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKL 77
NL + +F DGE V++ E RG + +IQST P ++N++E +++ D+L A ++
Sbjct: 23 NLGKASVGRFSDGEISVQINENVRGSDVFIIQSTCSPTNDNIMELVVMVDSLRRASAGRI 82
Query: 78 KIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLG-LYYDELYVFDIHNPKTLEHFPGIAKN 135
VIPY Y+RQDR + PI+ + + L + D + D+H + F N
Sbjct: 83 TAVIPYFGYARQDRRVRSARVPITAKVVADFLSSIGVDRVLTVDLHAEQIQGFFDVPVDN 142
Query: 136 IYPAEAIA-NYFKDKLGEGLILAPDKGALERAKRVAEVL-GLEYSHFEKERISPTEVRMK 193
++ + + + + +L ++++PD G + RA+ +A++L + + +K R ++
Sbjct: 143 VFGSLILLEDMLQRELKNPIVVSPDIGGVVRARAIAKLLYDTDMAIIDKRRPRANVSQIM 202
Query: 194 PVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKAV 253
+ DV ++ ++VDD+I TGGT+ KAA L+E GAK +F ATH VF+ A + + +V
Sbjct: 203 NIIGDVANRDCILVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPVFSGDAPKNLKNSV 262
Query: 254 -NELAVTNTIP 263
+E+ V +TIP
Sbjct: 263 IDEVVVCDTIP 273
>sp|P57266|KPRS_BUCAI RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE)
Length = 315
Score = 127 bits (316), Expect = 1e-28
Identities = 78/251 (31%), Positives = 140/251 (55%), Gaps = 7/251 (2%)
Query: 20 NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKL 77
NL + +F DGE V++ E RG + +IQST P ++N++E +++ D+L A ++
Sbjct: 26 NLGKASVGRFSDGEISVQINENVRGSDVFIIQSTCSPTNDNIMELVVMVDSLRRASAGRI 85
Query: 78 KIVIPYLAYSRQDRVTKEGE-PISVRAIMKMLG-LYYDELYVFDIHNPKTLEHFPGIAKN 135
VIPY Y+RQDR + PI+ + + L + D + D+H + F N
Sbjct: 86 TAVIPYFGYARQDRRVRSARVPITAKVVADFLSSIGVDRVLTVDLHAEQIQGFFDVPVDN 145
Query: 136 IYPAEAIA-NYFKDKLGEGLILAPDKGALERAKRVAEVL-GLEYSHFEKERISPTEVRMK 193
++ + + + + +L ++++PD G + RA+ +A++L + + +K R ++
Sbjct: 146 VFGSLILLEDMLQRELKNPIVVSPDIGGVVRARAIAKLLYDTDMAIIDKRRPRANVSQIM 205
Query: 194 PVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKAV 253
+ DV ++ ++VDD+I TGGT+ KAA L+E GAK +F ATH VF+ A + + +V
Sbjct: 206 NIIGDVANRDCILVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPVFSGDAPKNLKNSV 265
Query: 254 -NELAVTNTIP 263
+E+ V +TIP
Sbjct: 266 IDEVVVCDTIP 276
>emb|CAC04170.1| (AJ245726) phosphoribosyl diphosphate synthase isoform 4
[Saccharomyces cerevisiae]
Length = 354
Score = 126 bits (313), Expect = 3e-28
Identities = 85/281 (30%), Positives = 145/281 (51%), Gaps = 11/281 (3%)
Query: 5 GSGAKHLEEEISRHGN--LINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDEN-- 58
G+ L E+IS+ L V + ++ + E V + E R ++ +IQ+ Q+ N
Sbjct: 47 GNSHPDLAEQISKKLGIPLSKVGVYQYSNKETSVTIGESLRDEDVYIIQTGIGEQEINDF 106
Query: 59 LIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYV 117
L+E L+L A A +K+ VIP Y+RQD+ K PI+ + + +L D +
Sbjct: 107 LMELLILIHACKIASARKITTVIPNFPYARQDKKDKSRAPITAKLVANLLQTAGADHVIT 166
Query: 118 FDIHNPKTLEHFPGIAKNIYPAEAIANYFKDK--LGEGLILAPDKGALERAKRVAEVLGL 175
D+H + F N+Y ++ NY + K ++++PD G +R +A+ L L
Sbjct: 167 MDLHASQIQGFFHIPVDNLYAEPSVLNYIRTKTDFDNAILVSPDAGGAKRVAALADKLDL 226
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
++ KER EV + DV K+ L+VDD+ T GT++KA + L E GAKE+ +
Sbjct: 227 NFALIHKERQKANEVSKMVLVGDVTNKSCLLVDDMADTCGTLVKACDTLMEHGAKEVIAI 286
Query: 236 ATHGVFAEGAIERV-SKAVNELAVTNTIPTEVSKISIVDYI 275
THG+F+ A E++ + ++ + TNT+P ++ + I D I
Sbjct: 287 VTHGIFSGSAREKLRNSRLSRIVCTNTVPVDLD-LPIADQI 326
>gb|AAG20333.1| (AE005107) ribose phosphate pyrophosphokinase; PrsA [Halobacterium
sp. NRC-1]
Length = 281
Score = 125 bits (310), Expect = 7e-28
Identities = 86/276 (31%), Positives = 144/276 (52%), Gaps = 10/276 (3%)
Query: 1 MFVIGSGAKHLEEEISRHGN--LINVEIKKFPDGEKYVRVLER--GKEAIVIQSTYHPQD 56
M + GS ++ L ++ L +V FPDGE+ V V G+ A+++ ST P
Sbjct: 1 MLLSGSSSQSLAAALAAATGERLGDVTYDSFPDGEQLVTVPPAVDGERAVIVAST--PTS 58
Query: 57 ENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELY 116
+ IE L L DA +AG ++ V+PY+ Y+RQD G+P+S RA+ + + D +
Sbjct: 59 DAHIEVLQLQDAARDAGASEIITVLPYMGYARQDDAFDPGQPVSARAVARAISTGTDRVL 118
Query: 117 VFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLE 176
+ H LE F A + A +A L + + L+PD GA + A V + G
Sbjct: 119 TVNPHEDGVLECFDVPAAGVDAAPQLAAPLPADLTDPVFLSPDHGATDLATSVRDAYGTG 178
Query: 177 YS-HFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+ HF+K R S ++V ++P ++ G++V++ DDI++TG TM +A L + +FV
Sbjct: 179 VTDHFQKVRHSGSDVTVEPSEIQTAGRDVVVTDDIVATGTTMSEAITALDD--PARVFVA 236
Query: 236 ATHGVFAEGAIERVSKA-VNELAVTNTIPTEVSKIS 270
H + A A ++++A V + T+TI VS++S
Sbjct: 237 TVHPLLAGSARLKLARAGVEAVYGTDTIECAVSEVS 272
>gi|6319403 ribose-phosphate pyrophosphokinase 4; Prs4p [Saccharomyces
cerevisiae] >gi|585370|sp|P38063|KPR4_YEAST PROBABLE
RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 4 (PHOSPHORIBOSYL
PYROPHOSPHATE SYNTHETASE 4) >gi|626841|pir||S45804
probable ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
PRS4 - yeast (Saccharomyces cerevisiae)
>gi|536108|emb|CAA84888.1| (Z35829) ORF YBL068w
[Saccharomyces cerevisiae]
Length = 355
Score = 124 bits (309), Expect = 1e-27
Identities = 85/282 (30%), Positives = 144/282 (50%), Gaps = 12/282 (4%)
Query: 5 GSGAKHLEEEISRHGN--LINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDEN-- 58
G+ L E+IS+ L V + ++ + E V + E R ++ +IQ+ Q+ N
Sbjct: 47 GNSHPDLAEQISKKLGIPLSKVGVYQYSNKETSVTIGESLRDEDVYIIQTGIGEQEINDF 106
Query: 59 LIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYV 117
L+E L+L A A +K+ VIP Y+RQD+ K PI+ + + +L D +
Sbjct: 107 LMELLILIHACQIASARKITTVIPNFPYARQDKKDKSRAPITAKLVANLLQTAGADHVIT 166
Query: 118 FDIHNPKTLEHFPGIAKNIYPAEAIANYF---KDKLGEGLILAPDKGALERAKRVAEVLG 174
D+H + F N+Y ++ NY K ++++PD G +R +A+ L
Sbjct: 167 MDLHASQIQGFFHIPVDNLYAEPSVLNYIRARKTDFDNAILVSPDAGGAKRVAALADKLD 226
Query: 175 LEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFV 234
L ++ KER EV + DV K+ L+VDD+ T GT++KA + L E GAKE+
Sbjct: 227 LNFALIHKERQKANEVSKMVLVGDVTNKSCLLVDDMADTCGTLVKACDTLMEHGAKEVIA 286
Query: 235 VATHGVFAEGAIERV-SKAVNELAVTNTIPTEVSKISIVDYI 275
+ THG+F+ A E++ + ++ + TNT+P ++ + I D I
Sbjct: 287 IVTHGIFSGSAREKLRNSRLSRIVCTNTVPVDLD-LPIADQI 327
>pir||E82532 phosphoribosyl pyrophosphate synthetase XF2644 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107875|gb|AAF85441.1|AE004071_9 (AE004071)
phosphoribosyl pyrophosphate synthetase [Xylella
fastidiosa]
Length = 312
Score = 123 bits (305), Expect = 3e-27
Identities = 81/249 (32%), Positives = 133/249 (52%), Gaps = 14/249 (5%)
Query: 26 IKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPY 83
+ +F DGE+ V + E R +E V+Q T P ENL+E L++ DAL A + VIPY
Sbjct: 28 VSRFSDGEEQVEIEESVRRQEVFVVQPTCAPSAENLMELLVIIDALKRASVSSVTAVIPY 87
Query: 84 LAYSRQDRVTKE-GEPISVRAIMKML-GLYYDELYVFDIHNPKTLEHFPGIAKNIYP--- 138
YSRQDR + PI+ + KM+ + D + D+H + F N+Y
Sbjct: 88 FGYSRQDRRMRSLRVPITAKVAAKMISAIGADRVLTIDLHADQIQGFFDVPVDNVYASPL 147
Query: 139 --AEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLG-LEYSHFEKERISPTEVRMKPV 195
A+ Y D L ++++PD G + RA+ +A+ LG + + +K R + +
Sbjct: 148 LLADIWRAYGTDNL---IVVSPDVGGVVRARAMAKRLGDTDLAIIDKRRPRANVATVMNI 204
Query: 196 DVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA-VN 254
+VNGK ++VDD++ T GT+ AA L++ GA ++ TH V + A++ ++ + ++
Sbjct: 205 IGEVNGKTCVLVDDLVDTAGTLCAAAVALKQNGATKVVAYITHPVLSGPAVDNINNSELD 264
Query: 255 ELAVTNTIP 263
EL VT+TIP
Sbjct: 265 ELVVTDTIP 273
>gb|AAF50224.1| (AE003551) CG6767 gene product [alt 2] [Drosophila melanogaster]
Length = 341
Score = 122 bits (302), Expect = 6e-27
Identities = 92/314 (29%), Positives = 150/314 (47%), Gaps = 39/314 (12%)
Query: 6 SGAKH---LEEEISRHG-NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENL 59
SG H + + R G +L V KKF + E V + E RG++ ++QS ++NL
Sbjct: 8 SGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNL 67
Query: 60 IEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTK-----------------------EG 96
+E L++ +A A ++ VIP Y+RQD+ K
Sbjct: 68 MELLIMINACKIASASRVTAVIPCFPYARQDKKDKLAGSEDNAESKKLAKKNYDWKFRSR 127
Query: 97 EPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGE--- 152
PIS + + ML + D + D+H + F N+Y A+ + K+ + E
Sbjct: 128 APISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKN 187
Query: 153 GLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIIS 212
+I++PD G +R +A+ L +E++ KER EV + DV K ++VDD+
Sbjct: 188 SIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVDDMAD 247
Query: 213 TGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKAVNE-LAVTNTIP-----TEV 266
T GT++ AA+ L E GA +++ + THG+F+ AI R++ A E + VTNTIP +
Sbjct: 248 TCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDC 307
Query: 267 SKISIVDYIVKLGE 280
KI +D + E
Sbjct: 308 PKIQCIDVSMMFAE 321
>gi|6321776 ribose-phosphate pyrophosphokinase 3; Prs3p [Saccharomyces
cerevisiae] >gi|729906|sp|P38689|KPR3_YEAST
RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3 (PHOSPHORIBOSYL
PYROPHOSPHATE SYNTHETASE 3) >gi|626882|pir||S46824
ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PRS3 -
yeast (Saccharomyces cerevisiae)
>gi|587543|emb|CAA52437.1| (X74415) ribose-phosphate
pyrophosphokinase [Saccharomyces cerevisiae]
>gi|2289880|gb|AAB65063.1| (U11582) No definition line
found [Saccharomyces cerevisiae]
Length = 320
Score = 121 bits (301), Expect = 8e-27
Identities = 80/272 (29%), Positives = 138/272 (50%), Gaps = 12/272 (4%)
Query: 21 LINVEIKKFPDGEKYVRVLERGKEA---IVIQSTYHPQDENLIEALLLGDALSEAGFKKL 77
L + ++K+ P GE + E ++ I+ Q ++ ++E L++ +A A +++
Sbjct: 29 LTSSKLKRDPTGEVSFSIGESVRDQDIFIITQIGSGVVNDRVLELLIMINASKTASARRI 88
Query: 78 KIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNI 136
+IP Y+RQDR K PI+ + + ML D + D+H + F N+
Sbjct: 89 TAIIPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNL 148
Query: 137 YPAEAIANYFKDKLG--EGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKP 194
Y ++ Y K+ + + +I++PD G +RA +A+ L L ++ KER EV
Sbjct: 149 YAEPSVVRYIKENVNYMDSIIISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMV 208
Query: 195 VDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA-V 253
+ DV K +IVDD+ T GT+ KAA IL E AK + + THGV + AIE ++ + +
Sbjct: 209 LVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRAIENINNSKL 268
Query: 254 NELAVTNTIPTE-----VSKISIVDYIVKLGE 280
+ + TNT+P E K++++D L E
Sbjct: 269 DRVVCTNTVPFEEKIKKCPKLAVIDISSVLAE 300
>pir||T41036 ribose-phosphate pyrophosphokinase - fission yeast
(Schizosaccharomyces pombe) >gi|4008573|emb|CAA22490.1|
(AL034491) ribose-phosphate pyrophosphokinase
[Schizosaccharomyces pombe]
Length = 321
Score = 119 bits (295), Expect = 4e-26
Identities = 81/291 (27%), Positives = 150/291 (50%), Gaps = 15/291 (5%)
Query: 5 GSGAKHLEEEISRHGNLI--NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLI 60
G+ L E+++R L V + ++ + E V + E R ++ ++Q+ +++L+
Sbjct: 11 GNSHPELAEKVARRIGLSLGKVAVVQYSNRETSVTIGESVRDEDVFILQTGCGSINDHLM 70
Query: 61 EALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFD 119
E L++ +A A +++ +IP Y+RQD+ K PI+ R + ML + + D
Sbjct: 71 ELLIMINACRSASARRITAIIPCFPYARQDKKDKSRAPITARLVANMLQTAGCNHIITMD 130
Query: 120 IHNPKTLEHFPGIAKNIYPAEAIANYFKDKL----GEGLILAPDKGALERAKRVAEVLGL 175
+H + F N+Y ++ Y ++ + +I++PD G +RA +A+ L L
Sbjct: 131 LHASQIQGFFNVPVDNLYAEPSVLRYIRENIDTTVNPTVIVSPDAGGAKRATALADRLDL 190
Query: 176 EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
+++ KER EV + DV K ++VDD+ T GT+ AA L++ GAK ++ +
Sbjct: 191 DFALIHKERQKANEVSRMVLVGDVRDKLAILVDDMADTCGTLGLAAKTLKDNGAKAVYAI 250
Query: 236 ATHGVFAEGAIERVSK-AVNELAVTNTIPTE-----VSKISIVDYIVKLGE 280
THG+ + AI+ +++ A+ ++ VTNTIP + SKI +D L E
Sbjct: 251 VTHGILSGKAIKVINESALEKVIVTNTIPHDDKRSLCSKIETIDISGVLAE 301
>gi|11498197 ribose-phosphate pyrophosphokinase (prsA-1) [Archaeoglobus
fulgidus] >gi|7434669|pir||E69323 ribose-phosphate
pyrophosphokinase (prsA-1) homolog - Archaeoglobus
fulgidus >gi|2650034|gb|AAB90651.1| (AE001064)
ribose-phosphate pyrophosphokinase (prsA-1)
[Archaeoglobus fulgidus]
Length = 304
Score = 118 bits (294), Expect = 5e-26
Identities = 78/258 (30%), Positives = 132/258 (50%), Gaps = 15/258 (5%)
Query: 26 IKKFPDGEKYVRVLER--GKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPY 83
+ ++PDGEKY R G++ ++ S + DE + E LL+ + G + + V PY
Sbjct: 49 VDRYPDGEKYFRFASNIDGEDVVIFNSMHPNPDEIIFETLLIAETAYSNGARSVTCVFPY 108
Query: 84 LAYSRQDRVTKEGEPISVRAIMKML-GLYYDELYVFDIH---NPKTLEHFPGIAKNIYPA 139
AY+R K GE + ++ ++K+L ++ D H N +EH ++
Sbjct: 109 FAYARSLDTVK-GEALPIKTVVKVLKAAGVKKIITVDFHLQENVFGVEHV-----DLTGM 162
Query: 140 EAIANYFKDKLGEGL-ILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVD 198
E +A Y ++ + +LAPD+ A A++ A + K RI V + +
Sbjct: 163 EKLAEYCLEEFSDSFTVLAPDEKAAFWAEKFAAKANCDVVALRKIRIDAENVIIDDLRTG 222
Query: 199 VNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERV-SKAVNELA 257
V G +V+IVDDI+STGGT+ +AA I + GA+ +FV TH + A A+ R+ + ++
Sbjct: 223 VEG-DVVIVDDIVSTGGTVCQAARIAKRAGARRVFVACTHAILARDAMMRILESGIEDIV 281
Query: 258 VTNTIPTEVSKISIVDYI 275
T+TI + VS +S+ D I
Sbjct: 282 STDTILSPVSHVSVADVI 299
>gb|AAA29262.1| (M76553) phosphoribosylpyrophosphate synthetase [Leishmania
donovani]
Length = 371
Score = 117 bits (290), Expect = 2e-25
Identities = 83/280 (29%), Positives = 147/280 (51%), Gaps = 17/280 (6%)
Query: 3 VIGSGAKHLEEEIS--RHGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ--- 55
V G+G + L E ++ + + + ++ +GE VR+ E G + +IQST +
Sbjct: 50 VSGNGNRPLAEAVALLMGTHTHHTSVTQYSNGEVNVRINECVLGADVYIIQSTTGNEIID 109
Query: 56 -DENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYD 113
+ L+E LLL + + K + ++ P+ Y+RQDR T PIS + +M+ + +
Sbjct: 110 INTALMELLLLIRKMRLSNAKSVTVIAPFFGYARQDRKTNLRGPISASVVARMIVKMGVN 169
Query: 114 ELYVFDIHNPKTLEHFPGI-AKNIYPAEAIANYFKDK----LGEGLILAPDKGALERAKR 168
L D+H+ + F I N+ A A Y D+ + + ++++PD G +ERAK+
Sbjct: 170 RLASLDLHSNQIQGFFDNIPVDNLLMAHEFARYLHDQPWFNVDQMVVVSPDAGGVERAKQ 229
Query: 169 VAEVLGL-EYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILREL 227
+A++L + K RI+ +V +V G +IVDD+I TGGT++KA +L+EL
Sbjct: 230 LADILQVGRIVTIVKRRIAAGKVDTMQSVGEVAGFTCIIVDDMIDTGGTLVKACELLKEL 289
Query: 228 GAKEIFVVATHGVFAEGAIERVS--KAVNELAVTNTIPTE 265
GA + THG+ +R++ A+ +L V+++IP E
Sbjct: 290 GAVRVMACCTHGILTNPCPDRINNCSALEQLVVSDSIPQE 329
>pir||S60393 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PRS1 - yeast
(Candida albicans)
Length = 321
Score = 116 bits (289), Expect = 2e-25
Identities = 70/248 (28%), Positives = 127/248 (50%), Gaps = 7/248 (2%)
Query: 25 EIKKFPDGEKYVRVLERGKEA---IVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVI 81
E+K+ GE + E ++ I+ Q ++ + E +++ +A A +++ +++
Sbjct: 33 ELKRESTGEVQFSIGESVRDEDIFIICQIGSGEVNDRVFELMIMINACKTASARRITVIL 92
Query: 82 PYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAE 140
P Y+RQDR K PI+ + + ML D + D+H + F N+Y
Sbjct: 93 PNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEP 152
Query: 141 AIANYFKDKL--GEGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVD 198
++ Y K+ + E +I++PD G +RA +A+ L L + KER EV + D
Sbjct: 153 SVVRYIKETIDYSEAIIISPDAGGAKRAAGLADRLDLNFELIHKERARANEVSRMVLVGD 212
Query: 199 VNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA-VNELA 257
V K +IVDD+ T GT+ KAA +L + AK++ + THG+ + AI+ ++ + + ++
Sbjct: 213 VTDKICVIVDDMADTCGTLAKAAEVLLDNNAKDVIAIVTHGILSGNAIKNINNSKLKKVV 272
Query: 258 VTNTIPTE 265
TNT+P E
Sbjct: 273 CTNTVPFE 280
>sp|P46585|KPR1_CANAL RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1 (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE 1) >gi|882339|gb|AAA97558.1| (U23934)
phosphoribosyl pyrophosphate synthetase [Candida
albicans]
Length = 321
Score = 116 bits (288), Expect = 3e-25
Identities = 70/248 (28%), Positives = 127/248 (50%), Gaps = 7/248 (2%)
Query: 25 EIKKFPDGEKYVRVLERGKEA---IVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVI 81
E+K+ GE + E ++ I+ Q ++ + E +++ +A A +++ +++
Sbjct: 33 ELKRESTGEVQFSIGESVRDEDIFIICQIGSGEVNDRVFELMIMINACKTASARRITVIL 92
Query: 82 PYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPAE 140
P Y+RQDR K PI+ + + ML D + D+H + F N+Y
Sbjct: 93 PNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEP 152
Query: 141 AIANYFKDKL--GEGLILAPDKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVD 198
++ Y K+ + E +I++ D G +RA +A+ L L + KER EV + VD
Sbjct: 153 SVVRYIKETIDYSEAIIISSDAGGAKRAAGLADRLDLNFELIHKERARANEVSRMVLVVD 212
Query: 199 VNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERVSKA-VNELA 257
V K +IVDD+ T GT+ KAA +L + AK++ + THG+ + AI+ ++ + + ++
Sbjct: 213 VTDKICVIVDDMADTCGTLAKAAEVLLDNNAKDVIAIVTHGILSGNAIKNINNSKLKKVV 272
Query: 258 VTNTIPTE 265
TNT+P E
Sbjct: 273 CTNTVPFE 280
>gb|AAD03403.1| (AF042173) phosphoribosyl pyrophosphate synthetase [Giardia
intestinalis]
Length = 370
Score = 115 bits (284), Expect = 8e-25
Identities = 80/282 (28%), Positives = 143/282 (50%), Gaps = 17/282 (6%)
Query: 11 LEEEISRHGNLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQ-DENLIEALLLGD 67
L + + + +I + IK+F DGE ++ RG + ++ + P+ ++NL+E LL D
Sbjct: 25 LIQPLYEYSVVITLNIKQFSDGEINLQYESNIRGCDLFIVGAICPPRCNDNLMELLLAID 84
Query: 68 ALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKML-GLYYDELYVFDIHNPKTL 126
A A + +IPY Y+RQDR PIS + + +L D + V DIH +
Sbjct: 85 AAKRASAAHVTAIIPYFGYARQDRKAASRTPISAKLVTDLLIASGVDRVVVQDIHAAQIQ 144
Query: 127 EHFPG------IAKNIYPAEAIANYFKDKLGEGLILAPDKGALERAKRVAEVLGLEYSHF 180
FP I + +AI + F++ + ++++PD G R + +A L + +
Sbjct: 145 GFFPSSIPFDHIDGYLVFIQAIIDRFEEDIKNLIVVSPDAGGATRCRNLATQLHADIAII 204
Query: 181 EKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGV 240
+K R+ + V DVNGK L+ DDI+ T ++ KAA L+E GA+++F A+H V
Sbjct: 205 DKRRVVANMCDVMNVVGDVNGKICLLYDDIVDTARSLTKAAQALKEKGAEQVFACASHAV 264
Query: 241 FAEGAIERVSKA-VNELAVTNTIPTEVSKISIVDYIVKLGEK 281
+ A ++ ++ ++ + +++IP +I +LGEK
Sbjct: 265 LSGEATRKIKESCIDYILFSDSIPLSPKQIE------ELGEK 300
>pir||T40366 probable ribose-phosphate pyrophosphokinase - fission yeast
(Schizosaccharomyces pombe) >gi|2117302|emb|CAB09126.1|
(Z95620) putative ribose-phosphate pyrophosphokinase
[Schizosaccharomyces pombe]
Length = 341
Score = 111 bits (276), Expect = 7e-24
Identities = 83/298 (27%), Positives = 141/298 (46%), Gaps = 34/298 (11%)
Query: 11 LEEEISRHG--NLINVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLG 66
L E I H ++ VE+ KF +GE VR+ + RG + ++ +++L+E L++
Sbjct: 15 LTESICEHLCLDIGRVELSKFSNGETSVRIKQSVRGCDVYIVSPASGQVNDHLMELLIMI 74
Query: 67 DALSEAGFKKLKIVIPYLAYSRQ--DRVTKEGEPIS-----VRAIMKMLGLY-------- 111
A A KK+ V+P YSRQ + + G P+S V K G +
Sbjct: 75 SACKTASAKKVTAVLPVFPYSRQPDQKFSFSGAPLSDLQDAVVPCKKQTGYHPWIAQSGT 134
Query: 112 ----------YDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGE---GLILAP 158
D + D+H+P+ F N++ + +Y + +I++P
Sbjct: 135 LVADLLMCSGADHIITMDLHDPQFQGFFDIPVDNLFGRPLLKHYISLNIPNYHNAVIVSP 194
Query: 159 DKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMI 218
D G +RA +A+ LGL+++ K R + V DV K +++DD+I T T++
Sbjct: 195 DAGGAKRATAIADALGLDFALIHKNRRHEYGTSLMLVG-DVQNKVAILIDDLIDTAYTLV 253
Query: 219 KAANILRELGAKEIFVVATHGVFAEGAIERVS-KAVNELAVTNTIPTEVSKISIVDYI 275
+AA ++E GA +I+ + TH V + AIERV +++L VTNT P ++ D I
Sbjct: 254 RAAEFVKEHGASKIYALVTHCVLSGDAIERVKLSCIDKLIVTNTAPQTITPSGCFDII 311
>emb|CAC14347.1| (AL445945) ribose-phosphate pyrophosphokinase [Streptomyces
coelicolor]
Length = 317
Score = 107 bits (264), Expect = 2e-22
Identities = 63/227 (27%), Positives = 120/227 (52%), Gaps = 4/227 (1%)
Query: 41 RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPIS 100
R ++ ++Q P E+L+E L++ DA A ++ +V+P+ +Y+R D+ +
Sbjct: 49 RERDVFLVQPLVTPVQEHLVELLMMCDAARGASAGRITVVMPHYSYARSDKKDAPRISLG 108
Query: 101 VRAIMKML-GLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKD-KLGEGLILAP 158
R + +L + +H+P+ F +++ +A +F+ L +++P
Sbjct: 109 GRLVADLLVAAGASRVLAMTLHSPQVHGFFSVPVDHLHALRELAAHFRQYDLSRATVVSP 168
Query: 159 DKGALERAKRVAEVLGLEYSHFEKERISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMI 218
D G + A A +LG + + K+R + V + V DV G++V+++DD I+ G T++
Sbjct: 169 DLGNAKEAAAFARMLGAQVAAGAKQRYADDRVSISSVIGDVAGRDVIVLDDEIAKGSTVL 228
Query: 219 KAANILRELGAKEIFVVATHGVFAEGAIERVSKA--VNELAVTNTIP 263
+ + LRE G + I + THG+FA GA+ R+S+ V E+ TNT+P
Sbjct: 229 ELLDRLRESGPRTIRLACTHGLFAAGALGRLSEQPDVLEIVCTNTVP 275
>gi|4506133 phosphoribosyl pyrophosphate synthetase-associated protein 2 [Homo
sapiens] >gi|3043542|dbj|BAA25435.1| (AB007851) 41-kDa
phosphoribosylpyrophosphate synthetase-associated
protein [Homo sapiens]
Length = 369
Score = 104 bits (256), Expect = 2e-21
Identities = 83/283 (29%), Positives = 136/283 (47%), Gaps = 37/283 (13%)
Query: 24 VEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVI 81
V++ + P+ E V++ E RGK+ +IQ+ + ++E L++ A + K + VI
Sbjct: 49 VQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAKSIIGVI 108
Query: 82 PYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEA 141
PY YS+Q ++ K G +S M L D+H + F N+ +
Sbjct: 109 PYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPF 168
Query: 142 IANYFKDKLGE---GLILAPDKGALERAKRVAEVL--GLEYSHFEKE---------RISP 187
+ Y ++++ + +I+A + +RA+ AE L G+ H E + R SP
Sbjct: 169 LLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSP 228
Query: 188 TEVRM------------------KPVDV--DVNGKNVLIVDDIISTGGTMIKAANILREL 227
VR P+ V DV G+ +IVDDII + + AA L+E
Sbjct: 229 PMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKER 288
Query: 228 GAKEIFVVATHGVFAEGAIERVSK-AVNELAVTNTIPTEVSKI 269
GA +IFV+ATHG+ + A R+ + A++E+ VTNTIP EV K+
Sbjct: 289 GAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKL 331
>dbj|BAA19517.1| (D84434) 41-kDa phosphoribosylpyrophosphate synthetase-associated
protein [Rattus norvegicus]
Length = 369
Score = 101 bits (248), Expect = 1e-20
Identities = 81/283 (28%), Positives = 135/283 (47%), Gaps = 37/283 (13%)
Query: 24 VEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVI 81
V++ + P+ E V++ E RGK+ +IQ+ + ++E L++ A + K + VI
Sbjct: 49 VQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAKSIIGVI 108
Query: 82 PYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEA 141
PY YS+Q ++ K G +S M L D+H + F N+ +
Sbjct: 109 PYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPF 168
Query: 142 IANYFKDKLGE---GLILAPDKGALERAKRVAEVL--GLEYSHFEKE---------RISP 187
+ Y ++++ + +I+A + +RA+ AE L G+ H E + R SP
Sbjct: 169 LLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSP 228
Query: 188 TEVRM------------------KPVDV--DVNGKNVLIVDDIISTGGTMIKAANILREL 227
VR P+ V DV G+ +IVDDII + + AA L+E
Sbjct: 229 PMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKER 288
Query: 228 GAKEIFVVATHGVFAEGAIERVSK-AVNELAVTNTIPTEVSKI 269
GA +IFV+ATHG+ + A + + A++E+ VTNTIP E+ K+
Sbjct: 289 GAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKL 331
>gi|4506131 phosphoribosyl pyrophosphate synthetase-associated protein 1 [Homo
sapiens] >gi|7434665|pir||S71460 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) 39K regulatory chain -
human >gi|1381027|dbj|BAA09612.1| (D61391)
phosphoribosypyrophosphate synthetase-associated protein
39 [Homo sapiens]
Length = 356
Score = 96.7 bits (237), Expect = 3e-19
Identities = 78/275 (28%), Positives = 130/275 (46%), Gaps = 36/275 (13%)
Query: 31 DGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAYSR 88
+GE V + E RG++ +IQ+ + ++E L++ AL A + + VIPY YS+
Sbjct: 44 NGETRVEIKEFVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSK 103
Query: 89 QDRVTKEGEPISVRAIMKMLGLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKD 148
Q ++ K G + + + D+H + F N+ + + Y ++
Sbjct: 104 QSKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQE 163
Query: 149 KLGE---GLILAPDKGALERAKRVAEVL--GLEYSHFEKE---------RISPTEVR--- 191
++ +I+A A +RA+ AE L GL H E + R SP V+
Sbjct: 164 EIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNAT 223
Query: 192 --------------MKPVDV--DVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
P+ V DV G+ +IVDDII + + AA IL+E GA +I+V+
Sbjct: 224 VHPGLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVM 283
Query: 236 ATHGVFAEGAIERVSK-AVNELAVTNTIPTEVSKI 269
ATHG+ + A + + +V+E+ VTNT+P EV K+
Sbjct: 284 ATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKL 318
>gi|11424272 phosphoribosyl pyrophosphate synthetase-associated protein 1 [Homo
sapiens]
Length = 356
Score = 96.7 bits (237), Expect = 3e-19
Identities = 78/275 (28%), Positives = 130/275 (46%), Gaps = 36/275 (13%)
Query: 31 DGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAYSR 88
+GE V + E RG++ +IQ+ + ++E L++ AL A + + VIPY YS+
Sbjct: 44 NGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSK 103
Query: 89 QDRVTKEGEPISVRAIMKMLGLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKD 148
Q ++ K G + + + D+H + F N+ + + Y ++
Sbjct: 104 QSKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQE 163
Query: 149 KLGE---GLILAPDKGALERAKRVAEVL--GLEYSHFEKE---------RISPTEVR--- 191
++ +I+A A +RA+ AE L GL H E + R SP V+
Sbjct: 164 EIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNAT 223
Query: 192 --------------MKPVDV--DVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
P+ V DV G+ +IVDDII + + AA IL+E GA +I+V+
Sbjct: 224 VHPGLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVM 283
Query: 236 ATHGVFAEGAIERVSK-AVNELAVTNTIPTEVSKI 269
ATHG+ + A + + +V+E+ VTNT+P EV K+
Sbjct: 284 ATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKL 318
>pir||A53433 ribose-phosphate pyrophosphokinase (EC 2.7.6.1) 39K regulatory
chain - rat >gi|436779|dbj|BAA05068.1| (D26073)
phosphoribosylpyrophosphate synthetase-associated
protein (39 kDa) [Rattus norvegicus]
Length = 356
Score = 92.4 bits (226), Expect = 5e-18
Identities = 75/275 (27%), Positives = 129/275 (46%), Gaps = 36/275 (13%)
Query: 31 DGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAYSR 88
+GE V + E RG++ +IQ+ + ++E L++ AL A + + VIPY YS+
Sbjct: 44 NGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSK 103
Query: 89 QDRVTKEGEPISVRAIMKMLGLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKD 148
Q ++ K G + + + D+H + F N+ + + Y ++
Sbjct: 104 QSKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFCFPVDNLRASPFLLQYIQE 163
Query: 149 KLGE---GLILAPDKGALERAKRVAEVL--GLEYSHFEKE---------RISPTEVR--- 191
++ +I+A A +RA+ AE L GL H E + R SP V+
Sbjct: 164 EIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNAT 223
Query: 192 --------------MKPVDV--DVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVV 235
P+ V DV G+ +IVDDII + + AA L+E GA +I+V+
Sbjct: 224 VHPGLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAETLKERGAYKIYVM 283
Query: 236 ATHGVFAEGAIERVSKA-VNELAVTNTIPTEVSKI 269
ATHG+ + A + ++ ++E+ VTNT+P E+ K+
Sbjct: 284 ATHGILSAEAPRLIEESPIDEVVVTNTVPHELQKL 318
>pir||T26164 hypothetical protein W04G3.5 - Caenorhabditis elegans
>gi|3880487|emb|CAA92027.1| (Z68014) contains similarity
to Pfam domain: PF00156 (Phosphoribosyl transferase
domain), Score=69.0, E-value=3.3e-17, N=1~cDNA EST
yk115b2.3 comes from this gene~cDNA EST yk51b5.3 comes
from this gene~cDNA EST yk51b5.5 comes from this
gene~cDNA EST yk>
Length = 353
Score = 84.3 bits (205), Expect = 1e-15
Identities = 69/261 (26%), Positives = 123/261 (46%), Gaps = 33/261 (12%)
Query: 41 RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPIS 100
RGK ++QS + +++E L+L A + K + +++PYL YS+Q R+ + I+
Sbjct: 56 RGKHVFILQSGSKNVNNDVMELLVLIYACKTSMSKTITVIMPYLPYSKQCRMLRRSS-IA 114
Query: 101 VRAIMKML-GLYYDELYVFDIHNPKTLEHFPGIAKNIYPAEAIANYFKDKLGE---GLIL 156
++ + +M+ L D++ + F N+ + + K + + +I+
Sbjct: 115 MKLVAEMICKAGASRLVSLDLYKKEIQGFFSCPVDNLRASPFFLQHIKTNIPDYKNAIIV 174
Query: 157 APDKGALERAKRVAEVLGL------------EYSHFEKERISPT------------EVRM 192
A G + +A A+ L L E S E R SP E +
Sbjct: 175 AKSPGVMNKATSYADRLRLGVAVIHGEQKDEEESGLEDGRQSPPPNVTSYDFLPAQESKQ 234
Query: 193 KP---VDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKEIFVVATHGVFAEGAIERV 249
KP V DV G+ ++VDDII + + AA +L+ GA +I+V+ATHGV + A +
Sbjct: 235 KPPLTVVGDVGGRIAIMVDDIIDDAQSFVAAAEVLKARGAYKIYVIATHGVLSSDAPALL 294
Query: 250 -SKAVNELAVTNTIPTEVSKI 269
+ + E+ VTNT+P ++ K+
Sbjct: 295 EASPITEVIVTNTVPHDLQKM 315
>pir||G70167 phosphoribosyl pyrophosphate synthetase (prs) homolog - Lyme
disease spirochete >gi|2688465|gb|AAC66912.1| (AE001156)
phosphoribosyl pyrophosphate synthetase (prs) [Borrelia
burgdorferi]
Length = 406
Score = 80.4 bits (195), Expect = 2e-14
Identities = 71/264 (26%), Positives = 122/264 (45%), Gaps = 31/264 (11%)
Query: 22 INVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQD--------------ENLIEALLL 65
I V+ KF +GE +L+ R K+ ++Q + + ++++ +
Sbjct: 81 IPVKFVKFANGEFKTEILKTIRNKDIFIVQDVANAYEVEINSSEKIIMTVNDHIMNLMTT 140
Query: 66 GDALSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLG-LYYDELYVFDIHNPK 124
DA +A + ++IP YSRQD+ E ++ I + L L + DIH+
Sbjct: 141 IDACMQAKANSVSVIIPSYPYSRQDKKHSR-ECLTASLIGRFLEELGIRHILTLDIHSKA 199
Query: 125 TLEHFPGIA-KNIYPAEAIANYFKDKL----GEGLILAPDKGALERAKRVAEVLGLEYSH 179
F + +N+ + I N KD + +I++PD GA+ R K A L +
Sbjct: 200 IENVFRKVYFENLNVSYEIFNSLKDLIDIRDSNLVIVSPDTGAVSRNKFFASSLKSPLAL 259
Query: 180 FEKER--------ISPTEVRMKPVDVDVNGKNVLIVDDIISTGGTMIKAANILRELGAKE 231
KER ++ + + + + DV GKNV + DD+++TGGT+IKA +L+ +GAK+
Sbjct: 260 LYKERDYSRVSNDVADSNISVTKLLGDVEGKNVFMSDDMLATGGTLIKAMKLLKSMGAKK 319
Query: 232 IFVVATHGVFAEGAIERVSKAVNE 255
I + F AI+ KA E
Sbjct: 320 IICGISLPFFNGDAIKYFDKAYEE 343
>sp|P41831|KPRS_SCHPO RIBOSE-PHOSPHATE PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE
SYNTHETASE) >gi|1076924|pir||S51326 ribose-phosphate
pyrophosphokinase (EC 2.7.6.1) - fission yeast
(Schizosaccharomyces pombe) >gi|634096|emb|CAA58747.1|
(X83866) phosphoribosyl pyrophosphate synthetase
[Schizosaccharomyces pombe] >gi|4490652|emb|CAB11484.1|
(Z98762) ribose-phosphate pyrophosphokinase
[Schizosaccharomyces pombe]
Length = 409
Score = 71.4 bits (172), Expect = 1e-11
Identities = 42/168 (25%), Positives = 85/168 (50%), Gaps = 6/168 (3%)
Query: 23 NVEIKKFPDGEKYVRVLE--RGKEAIVIQSTYHPQDENLIEALLLGDALSEAGFKKLKIV 80
+V +K+F +GE V + E R K+ ++QS +++L+E L++ A K++ V
Sbjct: 29 DVSLKRFANGETSVEIRESVRDKDVFILQSGSSTVNDSLMELLIIISACKGGSAKRITAV 88
Query: 81 IPYLAYSRQDRVTKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLEHFPGIAKNIYPA 139
+PY YS+Q ++ K + I+ R + +L + D + D+H + F N+Y
Sbjct: 89 MPYFPYSKQSKMRKYRDAITARMVANLLTVAGVDHIITLDLHASQMQGFFTRPVDNLYAE 148
Query: 140 EAIANYFK---DKLGEGLILAPDKGALERAKRVAEVLGLEYSHFEKER 184
IA + + D E ++++ + G +R +A+ L L+++ +R
Sbjct: 149 PNIAEWIRRNVDDWEEAVVVSKNPGGAKRVTSLADTLNLDFALINTDR 196
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.317 0.138 0.379
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100042744
Number of Sequences: 2977
Number of extensions: 4052606
Number of successful extensions: 13304
Number of sequences better than 1.0e-10: 76
Number of HSP's better than 0.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 13124
Number of HSP's gapped (non-prelim): 77
length of query: 282
length of database: 189,106,746
effective HSP length: 58
effective length of query: 224
effective length of database: 154,394,500
effective search space: 34584368000
effective search space used: 34584368000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 164 (68.3 bits)