BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1128 (polI) DE:DNA polymerase I
(771 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|P77916|DPOL_PYRAB DNA POLYMERASE 1 (PAB POLYMERASE) >gi|74347... 1564 0.0
sp|P77932|DPOL_PYRSE DNA POLYMERASE >gi|1495770|emb|CAA90887.1| ... 1555 0.0
emb|CAA90888.1| (Z54174) DNA-dependent DNA polymerase [Pyrococcu... 1546 0.0
emb|CAC12847.1| (AJ250332) DNA polymerase [Pyrococcus sp. ST700] 1437 0.0
emb|CAB81809.1| (AJ004834) DNA polymerase [Pyrococcus glycovorans] 1429 0.0
emb|CAC12849.1| (AJ250335) DNA polymerase [Thermococcus glycovor... 1426 0.0
gb|AAA67131.1| (U00707) DNA polymerase [Pyrococcus sp.] 1417 0.0
sp|P80061|DPOL_PYRFU DNA POLYMERASE (PFU POLYMERASE) >gi|479862|... 1352 0.0
sp|P56689|DPOL_THEGO DNA POLYMERASE (TO POL) >gi|4699806|pdb|1TG... 1337 0.0
sp|Q56366|DPOL_THES9 DNA POLYMERASE >gi|7434808|pir||S67920 DNA-... 1323 0.0
pdb|1QHT|A Chain A, Dna Polymerase From Thermococcus Sp. 9on-7 A... 1317 0.0
pdb|1QQC|A Chain A, Crystal Structure Of An Archaebacterial Dna ... 1314 0.0
gb|AAA72101.1| (M74198) DNA dependent DNA polymerase [Thermococc... 1239 0.0
pdb|1D5A|A Chain A, Crystal Structure Of An Archaebacterial Dna ... 1214 0.0
sp|O59610|DPOL_PYRHO DNA POLYMERASE >gi|7446920|pir||C71210 prob... 957 0.0
sp|Q51334|DPOL_PYRSD DNA POLYMERASE (DEEP VENT DNA POLYMERASE) [... 912 0.0
emb|CAC12850.1| (AJ250333) DNA polymerase and endonucleases [The... 863 0.0
sp|P30317|DPOL_THELI DNA POLYMERASE (VENT DNA POLYMERASE) [CONTA... 806 0.0
emb|CAC18555.1| (AJ245819) DNA polymerase and endonucleases [The... 772 0.0
dbj|BAA06142.2| (D29671) DNA-dependent DNA polymerase [Pyrococcu... 706 0.0
pir||S71551 DNA-directed DNA polymerase (EC 2.7.7.7) KOD, intein... 702 0.0
sp|P74918|DPOL_THEFM DNA POLYMERASE (POL TFU) >gi|1655695|emb|CA... 692 0.0
sp|O33845|DPOL_THEST DNA POLYMERASE >gi|2293389|emb|CAA73475.1| ... 665 0.0
sp|P52025|DPOL_METVO DNA POLYMERASE >gi|495654|gb|AAA72443.1| (L... 510 e-143
gi|11498108 DNA polymerase B1 (polB) [Archaeoglobus fulgidus] >g... 501 e-140
sp|O27276|DPOL_METTH DNA POLYMERASE >gi|7482291|pir||C69028 DNA-... 486 e-136
dbj|BAA93703.1| (AB032376) DNA polymerase B3 [Sulfurisphaera ohw... 480 e-134
pir||B56277 DNA-directed DNA polymerase (EC 2.7.7.7) II - Pyrodi... 464 e-129
sp|O93746|DPO2_AERPE DNA POLYMERASE II >gi|7434801|pir||E72515 p... 440 e-122
gb|AAF27815.1|AF195019_1 (AF195019) family B DNA polymerase [Pyr... 431 e-119
dbj|BAA75663.1| (AB017501) DNA polymerase II [Aeropyrum pernix] 427 e-118
emb|CAC12848.1| (AJ250334) DNA polymerase [Thermococcus chitonop... 353 3e-96
sp|Q58295|DPOL_METJA DNA POLYMERASE >gi|2826345|gb|AAB98889.1| (... 311 2e-83
pir||E64410 DNA-directed DNA polymerase (EC 2.7.7.7) family B, i... 310 3e-83
gb|AAK40441.1| DNA polymerase III (DNA polymerase B3) (pfu polym... 251 2e-65
sp|P95979|DPO3_SULSO DNA POLYMERASE III (DNA POLYMERASE B3) >gi|... 251 2e-65
sp|O05706|DPO3_SULSH DNA POLYMERASE III (DNA POLYMERASE B3) >gi|... 247 3e-64
dbj|BAA99573.1| (AB037899) DNA polymerase delta catalytic chain ... 236 9e-61
emb|CAC12036.1| (AL445065) DNA polymerase (PolB), large chain re... 229 1e-58
sp|O48901|DPOD_SOYBN DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|74... 228 2e-58
dbj|BAA96899.1| (AB019227) DNA polymerase III catalytic subunit ... 226 6e-58
pir||S60677 DNA-directed DNA polymerase III (EC 2.7.7.7) - yeast... 225 1e-57
sp|P46588|DPOD_CANAL DNA POLYMERASE DELTA LARGE CHAIN (DNA POLYM... 225 1e-57
pir||T18222 DNA polymerase delta chain - yeast (Candida albicans... 224 2e-57
emb|CAB97239.1| (AL117202) similar to DNA polymerase alpha subun... 224 2e-57
sp|P52431|DPOD_MOUSE DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|48... 222 9e-57
pir||T40242 DNA polymerase delta large chain - fission yeast (S... 222 9e-57
gi|6755122 DNA polymerase delta 1, catalytic domain [Mus musculu... 221 3e-56
pir||S35455 DNA-directed DNA polymerase (EC 2.7.7.7) delta - hum... 220 4e-56
pir||T43266 DNA-directed DNA polymerase (EC 2.7.7.7) delta chain... 219 7e-56
gi|11067381 DNA polymerase delta, catalytic subunit [Rattus norv... 219 7e-56
gi|4505933 polymerase (DNA directed), delta 1, catalytic subunit... 219 1e-55
sp|P97283|DPOD_MESAU DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|18... 219 1e-55
gb|AAF49555.1| (AE003529) DNApol-delta gene product [Drosophila ... 218 2e-55
sp|O50607|DPO1_SULOH DNA POLYMERASE I (DNA POLYMERASE B1) >gi|26... 217 3e-55
sp|P28339|DPOD_BOVIN DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|89... 217 4e-55
sp|P54358|DPOD_DROME DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|10... 217 5e-55
emb|CAA43922.1| (X61920) DNA polymerase III catalytic subunit [... 216 6e-55
gi|6320101 largest and catalytic subunit of DNA polymerase III (... 216 6e-55
gb|AAB47255.1| (U83705) DNA polymerase delta' [Mesocricetus aura... 216 8e-55
emb|CAA33504.1| (X15477) DNA polymerase III large subunit (AA 1 ... 214 2e-54
sp|P26811|DPO1_SULSO DNA POLYMERASE I >gi|99266|pir||S23019 DNA-... 214 3e-54
gb|AAK40869.1| DNA polymerase I (DNA polymerase B1) (dpo1) [Sulf... 213 7e-54
gb|AAB53090.1| (U92875) DNA polymerase [Sulfolobus solfataricus]... 213 7e-54
pir||E69125 DNA-dependent DNA polymerase family B (PolB2) - Meth... 210 5e-53
gb|AAG19049.1| (AE005004) DNA polymerase B1; PolB1 [Halobacteriu... 208 1e-52
sp|P30316|DPOD_SCHPO DNA POLYMERASE DELTA LARGE CHAIN (DNA POLYM... 206 9e-52
pir||A56277 DNA-directed DNA polymerase (EC 2.7.7.7) I - Pyrodic... 205 2e-51
dbj|BAA07579.1| (D38573) DNA polymerase [Pyrodictium occultum] 205 2e-51
gb|AAG35630.1|AF202992_1 (AF202992) DNA polymerase alpha [Xenopu... 203 5e-51
sp|P30315|DPOD_PLAFK DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|32... 203 6e-51
pir||S17330 DNA-directed DNA polymerase (EC 2.7.7.7) delta - Pla... 203 8e-51
pir||T20698 hypothetical protein F10C2.4 - Caenorhabditis elegan... 201 2e-50
sp|O89042|DPOA_RAT DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|36... 201 3e-50
gi|8393995 polymerase (DNA-directed), alpha; polymerase (DNA-dir... 198 2e-49
sp|P95690|DPOL_SULAC DNA POLYMERASE I >gi|2129430|pir||JC5186 DN... 196 8e-49
sp|O93745|DPO1_AERPE DNA POLYMERASE I >gi|7434800|pir||F72763 pr... 196 8e-49
sp|O48653|DPOA_ORYSA DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|... 195 2e-48
sp|P21189|DPO2_ECOLI DNA POLYMERASE II (POL II) >gi|67056|pir||J... 195 2e-48
dbj|BAB10944.1| (AB020742) DNA polymerase alpha 1 [Arabidopsis t... 194 3e-48
dbj|BAA75662.1| (AB017500) DNA polymerase [Aeropyrum pernix] 193 7e-48
gi|6679409 DNA polymerase alpha 1, 180 kDa [Mus musculus] >gi|54... 192 1e-47
gb|AAA63764.1| (M38283) DNA polymerase II [Escherichia coli] 191 3e-47
sp|Q94636|DPOA_OXYNO DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|... 189 1e-46
gb|AAA24406.1| (M62646) DNA polymerase II [Escherichia coli] >gi... 185 2e-45
sp|P27727|DPOA_TRYBB DNA POLYMERASE ALPHA CATALYTIC SUBUNIT (DNA... 183 5e-45
sp|Q27152|DPOA_OXYTR DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|... 183 6e-45
gb|AAF55908.1| (AE003735) DNApol-alpha180 gene product [Drosophi... 182 1e-44
pir||S28079 DNA-directed DNA polymerase (EC 2.7.7.7) alpha - fru... 182 2e-44
gb|AAB24152.1| (S48157) DNA polymerase-primase 180 kda subunit [... 181 2e-44
sp|P28040|DPOA_SCHPO DNA POLYMERASE ALPHA CATALYTIC SUBUNIT (DNA... 179 9e-44
emb|CAB57881.1| (X69673) DNA-directed DNA polymerase [Schizosacc... 179 9e-44
gi|6324227 DNA polymerase I alpha subunit, p180; Pol1p [Saccharo... 178 3e-43
emb|CAB90776.1| (AL355632) dna polymerase zeta catalytic subunit... 178 3e-43
gb|AAA34888.1| (J03268) polymerase I [Saccharomyces cerevisiae] 176 6e-43
sp|P26019|DPOA_DROME DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|... 175 2e-42
dbj|BAA32745.1| (AB011813) DNA polymerase alpha 180K subunit [Dr... 175 2e-42
gb|AAA81882.1| (U00429) DNA polymerase [Pyrococcus sp. GI-J] 171 2e-41
pir||E82227 DNA polymerase II VC1212 [imported] - Vibrio cholera... 171 3e-41
sp|O00874|DPOA_LEIDO DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|... 170 4e-41
gi|9631753 PBVC-1 DNA polymerase [Paramecium bursaria Chlorella ... 169 1e-40
gb|AAB94881.1| (AF028831) DNA polymerase [Cenarchaeum symbiosum] 169 1e-40
pir||T31321 DNA-directed DNA polymerase (EC 2.7.7.7) B - Cenarch... 169 1e-40
dbj|BAA35142.1| (AB011500) DNA polymerase [Chlorella virus K2] 168 2e-40
gi|9625657 BALF5 DNA polymerase (early), homologous to many DNA ... 166 7e-40
gb|AAC62689.1| (AF083071) archael family B DNA polymerase [Cenar... 166 9e-40
gb|AAC57976.2| (AF005479) DNA polymerase [retroperitoneal fibrom... 166 9e-40
sp|P30320|DPOL_CHVN2 DNA POLYMERASE >gi|281076|pir||B42543 DNA-d... 164 4e-39
pir||A42543 DNA-directed DNA polymerase (EC 2.7.7.7) - Chlorella... 164 4e-39
gb|AAF16520.1|AF191042_1 (AF191042) DNA-dependent DNA polymerase... 163 6e-39
gb|AAF16522.1|AF191043_1 (AF191043) DNA-dependent DNA polymerase... 163 7e-39
gb|AAG20982.1| (AE005165) DNA polymerase B2; PolB2 [Halobacteriu... 163 7e-39
gb|AAC57086.1| (U75698) ORF 9; DNA polymerase homolog; EBV BALF5... 161 3e-38
gb|AAB62593.1| (U93872) ORF 09, DNA polymerase homolog [Kaposi's... 161 3e-38
gi|10140935 DNA Polymerase [Alcelaphine herpesvirus 1] >gi|74347... 161 3e-38
sp|O71121|DPOL_RHCM6 DNA POLYMERASE >gi|2944240|gb|AAC05256.1| (... 159 1e-37
pir||G83410 DNA polymerase II PA1886 [imported] - Pseudomonas ae... 159 1e-37
gb|AAF80107.1|AF268039_1 (AF268039) DNA polymerase; DPOL [porcin... 158 3e-37
gb|AAF80108.1|AF268040_1 (AF268040) DNA polymerase; DPOL [porcin... 157 3e-37
gb|AAF80109.1|AF268041_1 (AF268041) DNA polymerase; DPOL [porcin... 157 3e-37
gb|AAF80111.1|AF268042_2 (AF268042) DNA polymerase; DPOL [porcin... 157 3e-37
gi|9628340 U38, DNA polymerase [Human herpesvirus 6] >gi|118883|... 152 2e-35
gb|AAB67116.1| (AF013260) DNA-dependent DNA polymerase homolog [... 152 2e-35
pir||T43998 DNA polymerase [imported] - human herpesvirus 6 (str... 152 2e-35
gi|9625965 DNA polymerase [Saimiriine herpesvirus 2] >gi|118886... 151 2e-35
gi|9633109 U38 [Human herpesvirus 6B] >gi|11261521|pir||T44185 p... 151 2e-35
gi|9628761 DNA polymerase [Human herpesvirus 7] >gi|1706511|sp|P... 150 4e-35
gi|6325090 DNA polymerase zeta subunit; Rev3p [Saccharomyces cer... 150 4e-35
sp|P27172|DPOL_MCMVS DNA POLYMERASE >gi|67043|pir||DJBEMC DNA-di... 149 1e-34
gb|AAC40752.1| (AF037218) catalytic subunit of replicative DNA p... 148 2e-34
pir||T02155 DNA-directed DNA polymerase homolog T1F15.3 - Arabid... 142 2e-32
gb|AAF07803.1|AC011020_3 (AC011020) putative DNA polymerase zeta... 142 2e-32
gb|AAF63493.1|AF239684_1 (AF239684) polymerase [green turtle her... 141 2e-32
gb|AAG30224.1| (AF298216) DNA polymerase zeta catalytic subunit ... 133 6e-30
gb|AAB88486.1| (AF035537) DNA polymerase zeta [Homo sapiens] 132 1e-29
sp|O60673|DPOZ_HUMAN DNA POLYMERASE ZETA CATALYTIC SUBUNIT (HREV... 132 1e-29
gi|4506483 REV3 (yeast homolog)-like, catalytic subunit of DNA p... 132 1e-29
emb|CAB75862.1| (AL080317) dJ1112D6.2 (REV3 (yeast homolog)-like... 132 1e-29
gb|AAG09402.1|AF179428_1 (AF179428) DNA polymerase zeta catalyti... 132 1e-29
gi|11417569 REV3 (yeast homolog)-like, catalytic subunit of DNA ... 132 1e-29
sp|P04292|DPOL_HSV1K DNA POLYMERASE >gi|67034|pir||DJBEK1 DNA-di... 132 2e-29
pir||T17202 DNA-directed DNA polymerase (EC 2.7.7.7) zeta chain ... 131 4e-29
dbj|BAA90768.1| (AB031049) DNA polymerase [Mus musculus] 131 4e-29
sp|Q61493|DPOZ_MOUSE DNA POLYMERASE ZETA CATALYTIC SUBUNIT (SEIZ... 130 7e-29
gb|AAG30223.1| (AF298215) DNA polymerase zeta catalytic subunit ... 129 9e-29
gi|9629411 DNA polymerase [human herpesvirus 1] >gi|118878|sp|P0... 129 9e-29
pir||DJBEV1 DNA-directed DNA polymerase (EC 2.7.7.7) - human her... 129 9e-29
sp|P09854|DPOL_HSV1S DNA POLYMERASE >gi|67035|pir||DJBE16 DNA-di... 129 1e-28
sp|P07917|DPOL_HSV1A DNA POLYMERASE >gi|67036|pir||DJBEAN DNA-di... 129 1e-28
gb|AAA74383.1| (L24487) DNA polymerase [Pseudorabies virus] 128 2e-28
gi|9625903 ORF28 (AA1-1194) [Human herpesvirus 3] >gi|118893|sp|... 127 4e-28
gb|AAF59191.1| (AE003839) CG1925 gene product [Drosophila melano... 113 6e-24
gb|AAC77870.1| (AC005623) putative DNA polymerase epsilon cataly... 108 3e-22
gb|AAF18240.1|AC011438_2 (AC011438) T23G18.11 [Arabidopsis thali... 99 1e-19
sp|Q85428|DPOL_RCMVM DNA POLYMERASE 99 2e-19
gi|9845346 pR54 [rat cytomegalovirus Maastricht] >gi|9800279|gb|... 99 2e-19
gb|AAD01637.1| (AF019254) DNA polymerase epsilon homolog [Asperg... 98 5e-19
gb|AAA23684.1| (M37727) DNA polymerase II [Escherichia coli] 96 1e-18
emb|CAB58420.1| (AL122012) probable DNA polymerase zeta catalyti... 95 3e-18
pir||T21712 hypothetical protein F33H2.5 - Caenorhabditis elegan... 90 8e-17
gi|6324067 DNA polymerase II; Pol2p [Saccharomyces cerevisiae] >... 85 3e-15
emb|CAA63235.1| (X92494) ORF N0825 [Saccharomyces cerevisiae] 85 3e-15
sp|P87154|DPOE_SCHPO DNA POLYMERASE EPSILON, CATALYTIC SUBUNIT A... 81 4e-14
gi|9631050 DNA polymerase [Lymantria dispar nucleopolyhedrovirus... 77 6e-13
gi|5453926 polymerase (DNA directed), epsilon [Homo sapiens] >gi... 76 1e-12
gb|AAD44690.1| (AF127975) DNA polymerase epsilon catalytic subun... 76 1e-12
gb|AAD44691.1| (AF127975) DNA polymerase epsilon catalytic subun... 76 1e-12
gb|AAD44692.1| (AF127975) DNA polymerase epsilon catalytic subun... 76 1e-12
gb|AAD45244.1|AF123502_1 (AF123502) DNA polymerase epsilon catal... 75 3e-12
gi|6755124 DNA polymerase epsilon [Mus musculus] >gi|5669844|gb|... 74 5e-12
sp|Q07864|DPOE_HUMAN DNA POLYMERASE EPSILON, CATALYTIC SUBUNIT A... 73 1e-11
pir||G02434 DNA-directed DNA polymerase (EC 2.7.7.7) epsilon cat... 71 5e-11
>sp|P77916|DPOL_PYRAB DNA POLYMERASE 1 (PAB POLYMERASE) >gi|7434799|pir||C75023 DNA
polymerase I PAB1128 - Pyrococcus abyssi (strain Orsay)
>gi|5459139|emb|CAB50625.1| (AJ248288) DNA polymerase I
[Pyrococcus abyssi]
Length = 771
Score = 1564 bits (4005), Expect = 0.0
Identities = 771/771 (100%), Positives = 771/771 (100%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG
Sbjct: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY
Sbjct: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY
Sbjct: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK
Sbjct: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE
Sbjct: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL
Sbjct: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID 540
DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID
Sbjct: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID 540
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE 600
TDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE
Sbjct: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE 600
Query: 601 GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL 660
GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL
Sbjct: 601 GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL 660
Query: 661 VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF 720
VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF
Sbjct: 661 VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF 720
Query: 721 DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLKF 771
DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLKF
Sbjct: 721 DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLKF 771
>sp|P77932|DPOL_PYRSE DNA POLYMERASE >gi|1495770|emb|CAA90887.1| (Z54173) DNA-dependent
DNA polymerase; endonuclease [Pyrococcus sp.]
Length = 771
Score = 1555 bits (3981), Expect = 0.0
Identities = 767/771 (99%), Positives = 768/771 (99%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG
Sbjct: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY
Sbjct: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY
Sbjct: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK
Sbjct: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE
Sbjct: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL
Sbjct: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID 540
DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELES GFKVLYID
Sbjct: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESSGFKVLYID 540
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE 600
TDGLYATIPGAK EIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE
Sbjct: 541 TDGLYATIPGAKPNEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE 600
Query: 601 GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL 660
GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL
Sbjct: 601 GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL 660
Query: 661 VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF 720
VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF
Sbjct: 661 VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF 720
Query: 721 DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLKF 771
DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDL+YQKTKQVGLGAWLKF
Sbjct: 721 DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTKQVGLGAWLKF 771
>emb|CAA90888.1| (Z54174) DNA-dependent DNA polymerase [Pyrococcus abyssi]
Length = 771
Score = 1546 bits (3960), Expect = 0.0
Identities = 762/771 (98%), Positives = 763/771 (98%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG
Sbjct: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY
Sbjct: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY
Sbjct: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK
Sbjct: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQRMGDSLAVEIKGRIHFDLFP IRRTINLPTYTLE VYE IFGKSKEKVYAHEIAEAWE
Sbjct: 241 MQRMGDSLAVEIKGRIHFDLFPAIRRTINLPTYTLETVYEVIFGKSKEKVYAHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVT ELGKEFFPMEAQLARLVG PVWDVSRSSTGNLVEWFLL K
Sbjct: 301 TGKGLERVAKYSMEDAKVTSELGKEFFPMEAQLARLVGHPVWDVSRSSTGNLVEWFLLTK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDEREYERRLRESYEGGYV EPEKGLWEGIVSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEREYERRLRESYEGGYVNEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL
Sbjct: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID 540
DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID
Sbjct: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID 540
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE 600
TDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE
Sbjct: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEE 600
Query: 601 GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL 660
GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL
Sbjct: 601 GKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKL 660
Query: 661 VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF 720
VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVL GDGPISKRAIAIEEF
Sbjct: 661 VIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLXGDGPISKRAIAIEEF 720
Query: 721 DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLKF 771
DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDL+YQKTKQVGLGAWLKF
Sbjct: 721 DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTKQVGLGAWLKF 771
>emb|CAC12847.1| (AJ250332) DNA polymerase [Pyrococcus sp. ST700]
Length = 759
Score = 1437 bits (3680), Expect = 0.0
Identities = 693/759 (91%), Positives = 736/759 (96%), Gaps = 1/759 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITE+GKPIIR+FKKE G+FKVEYDR FRPYIYALLKDDSAID+V+KIT+ERHG
Sbjct: 1 MILDADYITENGKPIIRLFKKENGKFKVEYDRNFRPYIYALLKDDSAIDDVRKITSERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
K+VR+ +VEKV KKFLGRPIEVWKLY EHPQDVPAIR+KIREHPAV+DIFEYDIPFAKRY
Sbjct: 61 KVVRVIDVEKVSKKFLGRPIEVWKLYFEHPQDVPAIRDKIREHPAVIDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEGNEEL+FLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWK IDLPY
Sbjct: 121 LIDKGLIPMEGNEELSFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKKIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVV++EREMIKRLV++IREKDPD+IITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK
Sbjct: 181 VEVVANEREMIKRLVRIIREKDPDIIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQR+G+SLAVEIKGRIHFDLFPVIRRTINLPTYTL VYEAIFGK KEKVY HEIAEAWE
Sbjct: 241 MQRLGESLAVEIKGRIHFDLFPVIRRTINLPTYTLRTVYEAIFGKPKEKVYPHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVT+ELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGKGLERVAKYSMEDAKVTYELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDE+EYE+RLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEKEYEKRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C +YD AP+VGHRFCKDFPGFIPSLLG+LLEERQKIKKRMKESKDP+EKKLL
Sbjct: 421 PDTLNREGCGKYDEAPEVGHRFCKDFPGFIPSLLGDLLEERQKIKKRMKESKDPIEKKLL 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYID 540
DYRQRAIKILANS+YGYYGYAKARWYCKECAESVTAWGRQYI+LVRRELE RGFKVLYID
Sbjct: 481 DYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGRQYIELVRRELEERGFKVLYID 540
Query: 541 TDGLYATIPGAKH-EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
TDGLYATIPG K+ EEIK KAL+FV YINSKLPG+LELEYEGFY RGFFVTKKKYALIDE
Sbjct: 541 TDGLYATIPGEKNWEEIKRKALEFVNYINSKLPGILELEYEGFYTRGFFVTKKKYALIDE 600
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
EGKI+TRGLEIVRRDWSEIAKETQAKVLEAILKHGNV+EAVKIVKEVTEKLS YEIP EK
Sbjct: 601 EGKIITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSNYEIPVEK 660
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVIYEQITRPL+EYKAIGPHVAVAKRLAAKG+K+KPGMVIGY++LRGDGPISKRAIAIEE
Sbjct: 661 LVIYEQITRPLNEYKAIGPHVAVAKRLAAKGIKIKPGMVIGYVLLRGDGPISKRAIAIEE 720
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQ 758
FD KKHKYDAEYYIENQVLPAVERIL+AFGY+KEDL++Q
Sbjct: 721 FDGKKHKYDAEYYIENQVLPAVERILKAFGYKKEDLRWQ 759
>emb|CAB81809.1| (AJ004834) DNA polymerase [Pyrococcus glycovorans]
Length = 775
Score = 1429 bits (3659), Expect = 0.0
Identities = 695/770 (90%), Positives = 732/770 (94%), Gaps = 1/770 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITEDGKPIIRIFKKE GEFKVEYDR FRPYIYALLKDDS IDEVKKITAERHG
Sbjct: 1 MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLKDDSQIDEVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRI +VEKV+KKFLGRPIEVWKLY EHPQDVPAIR+KIREHPAVVDIFEYDIPFAKRY
Sbjct: 61 KIVRIVDVEKVKKKFLGRPIEVWKLYFEHPQDVPAIRDKIREHPAVVDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIETLYHEGEEF KGPIIMISYADEEGAKVITWK +DLPY
Sbjct: 121 LIDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEGAKVITWKKVDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKR +KVIREKDPDVIITYNGD+FD PYL+KRAEKLGIKLPLGRD SEPK
Sbjct: 181 VEVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAEKLGIKLPLGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQR+GD AVEIKGRIHFDL+ VIRRTINLPTYTLEAVYEAIFGK KEKVYAHEIAEAWE
Sbjct: 241 MQRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVT+ELG+EFFPMEAQL+RLVGQP+WDVSRSSTGNLVEW+LLRK
Sbjct: 301 TGKGLERVAKYSMEDAKVTYELGREFFPMEAQLSRLVGQPLWDVSRSSTGNLVEWYLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDEREYERRLRESY GGYVKEPEKGLWEG+VSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEREYERRLRESYAGGYVKEPEKGLWEGLVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C EYDVAP+V H+FCKDFPGFIPSLL LL+ERQ+IK+RMK SKDP+EKK+L
Sbjct: 421 PDTLNREGCMEYDVAPEVKHKFCKDFPGFIPSLLKRLLDERQEIKRRMKASKDPIEKKML 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR+YI+ VR+ELE + GFKVLYI
Sbjct: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFGFKVLYI 540
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDGLYATIPGAK EEIK KAL+FVEYIN+KLPGLLELEYEGFY RGFFVTKKKYALIDE
Sbjct: 541 DTDGLYATIPGAKPEEIKRKALEFVEYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDE 600
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
EGKI+TRGLEIVRRDWSEIAKETQAKVLEAILKHGNV+EAVKIVKEVTEKLSKYEIPPEK
Sbjct: 601 EGKIITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEIPPEK 660
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVIYEQITRPL EYKAIGPHVAVAKRLAA+GVKV+PGMVIGYIVLRGDGPISKRAI EE
Sbjct: 661 LVIYEQITRPLHEYKAIGPHVAVAKRLAARGVKVRPGMVIGYIVLRGDGPISKRAILAEE 720
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWL 769
FDP+KHKYDAEYYIENQVLPAV RIL AFGYRKEDL++QKTKQ GL AWL
Sbjct: 721 FDPRKHKYDAEYYIENQVLPAVLRILEAFGYRKEDLRWQKTKQTGLTAWL 770
>emb|CAC12849.1| (AJ250335) DNA polymerase [Thermococcus glycovorans]
Length = 775
Score = 1426 bits (3652), Expect = 0.0
Identities = 693/770 (90%), Positives = 732/770 (95%), Gaps = 1/770 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITEDGKPIIRIFKKE GEFKVEYDR FRPYIYALLKDDS IDEVKKITAERHG
Sbjct: 1 MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLKDDSQIDEVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRI +VEKV+KKFLGRPIEVWKLY EHPQDVPAIR+KIREHPAVVDIFEYDIPFAKRY
Sbjct: 61 KIVRIVDVEKVKKKFLGRPIEVWKLYFEHPQDVPAIRDKIREHPAVVDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIETLYHEGEEF KGPIIMISYADEEGAKVITWK +DLPY
Sbjct: 121 LIDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEGAKVITWKKVDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKR +KVIREKDPDVIITYNGD+FD PYL+KRAEKLGIKLPLGRD SEPK
Sbjct: 181 VEVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAEKLGIKLPLGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQR+GD AVEIKGRIHFDL+ VIRRTINLPTYTLEAVYEAIFGK KEKVYAHEIAEAWE
Sbjct: 241 MQRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVT+ELG+EFFPMEAQL+RLVGQP+WDVSRSSTGNLVEW+LLRK
Sbjct: 301 TGKGLERVAKYSMEDAKVTYELGREFFPMEAQLSRLVGQPLWDVSRSSTGNLVEWYLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDEREYERRLRESY GGYVKEPEKGLWEG+VSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEREYERRLRESYAGGYVKEPEKGLWEGLVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C+EYDVAP+V H+FCKDFPGFIPSLL LL+ERQ+IK++MK SKDP+EKK+L
Sbjct: 421 PDTLNREGCREYDVAPEVKHKFCKDFPGFIPSLLKRLLDERQEIKRKMKASKDPIEKKML 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR+YI+ VR+ELE + GFKVLYI
Sbjct: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFGFKVLYI 540
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDGLYATIPGAK EEIK KAL+FVEYIN+KLPGLLELEYEGFY RGFFVTKKKYALIDE
Sbjct: 541 DTDGLYATIPGAKPEEIKRKALEFVEYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDE 600
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
EGKI+TRGLEIVRRDWSEIAKETQAKVLEAILKHGNV+EAVKIVKEVTEKLSKYEIPPEK
Sbjct: 601 EGKIITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEIPPEK 660
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVIYEQITRPL EYKAIGPHVAVAKRLAA+GVKV+PGMVIGYIVLRGDGPISKRAI EE
Sbjct: 661 LVIYEQITRPLHEYKAIGPHVAVAKRLAARGVKVRPGMVIGYIVLRGDGPISKRAILAEE 720
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWL 769
FDP+KHKYDAEYYIENQVLPAV RIL AFGYRK DL++QKTKQ GL AWL
Sbjct: 721 FDPRKHKYDAEYYIENQVLPAVLRILEAFGYRKGDLRWQKTKQTGLTAWL 770
>gb|AAA67131.1| (U00707) DNA polymerase [Pyrococcus sp.]
Length = 775
Score = 1417 bits (3628), Expect = 0.0
Identities = 688/770 (89%), Positives = 731/770 (94%), Gaps = 1/770 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITEDGKPIIRIFKKE GEFKVEYDR FRPYIYALLKDDS IDEV+KITAERHG
Sbjct: 1 MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLKDDSQIDEVRKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRI + EKV+KKFLGRPIEVW+LY EHPQDVPAIR+KIREH AV+DIFEYDIPFAKRY
Sbjct: 61 KIVRIIDAEKVRKKFLGRPIEVWRLYFEHPQDVPAIRDKIREHSAVIDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIETLYHEGEEF KGPIIMISYADEE AKVITWK IDLPY
Sbjct: 121 LIDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEEAKVITWKKIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKR +KVIREKDPDVIITYNGD+FD PYL+KRAEKLGIKLPLGRD SEPK
Sbjct: 181 VEVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAEKLGIKLPLGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQR+GD AVEIKGRIHFDL+ VIRRTINLPTYTLEAVYEAIFGK KEKVYAHEIAEAWE
Sbjct: 241 MQRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVT+ELG+EFFPMEAQL+RLVGQP+WDVSRSSTGNLVEW+LLRK
Sbjct: 301 TGKGLERVAKYSMEDAKVTYELGREFFPMEAQLSRLVGQPLWDVSRSSTGNLVEWYLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDEREYERRLRESY GGYVKEPEKGLWEG+VSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEREYERRLRESYAGGYVKEPEKGLWEGLVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C+EYDVAP+VGH+FCKDFPGFIPSLL LL+ERQ+IK++MK SKDP+EKK+L
Sbjct: 421 PDTLNREGCREYDVAPEVGHKFCKDFPGFIPSLLKRLLDERQEIKRKMKASKDPIEKKML 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR+YI+ VR+ELE + GFKVLYI
Sbjct: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFGFKVLYI 540
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDGLYATIPGAK EEIK+KAL+FV+YIN+KLPGLLELEYEGFY RGFFVTKKKYALIDE
Sbjct: 541 DTDGLYATIPGAKPEEIKKKALEFVDYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDE 600
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
EGKI+TRGLEIVRRDWSEIAKETQAKVLEAILKHGNV+EAVKIVKEVTEKLSKYEIPPEK
Sbjct: 601 EGKIITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEIPPEK 660
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVIYEQITRPL EYKAIGPHVAVAKRLAA+GVKV+PGMVIGYIVLRGDGPISKRAI EE
Sbjct: 661 LVIYEQITRPLHEYKAIGPHVAVAKRLAARGVKVRPGMVIGYIVLRGDGPISKRAILAEE 720
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWL 769
FD +KHKYDAEYYIENQVLPAV RIL AFGYRKEDL++QKTKQ GL AWL
Sbjct: 721 FDLRKHKYDAEYYIENQVLPAVLRILEAFGYRKEDLRWQKTKQTGLTAWL 770
>sp|P80061|DPOL_PYRFU DNA POLYMERASE (PFU POLYMERASE) >gi|479862|pir||S35543 DNA-directed
DNA polymerase (EC 2.7.7.7) - Pyrococcus furiosus
>gi|216918|dbj|BAA02362.1| (D12983) DNA polymerase
[Pyrococcus furiosus] >gi|2347063|gb|AAB67984.1|
(U84155) DNA-dependent DNA polymerase [Pyrococcus
woesei]
Length = 775
Score = 1352 bits (3462), Expect = 0.0
Identities = 645/770 (83%), Positives = 713/770 (91%), Gaps = 1/770 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITE+GKP+IR+FKKE G+FK+E+DRTFRPYIYALL+DDS I+EVKKIT ERHG
Sbjct: 1 MILDVDYITEEGKPVIRLFKKENGKFKIEHDRTFRPYIYALLRDDSKIEEVKKITGERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRI +VEKV+KKFLG+PI VWKLYLEHPQDVP IREK+REHPAVVDIFEYDIPFAKRY
Sbjct: 61 KIVRIVDVEKVEKKFLGKPITVWKLYLEHPQDVPTIREKVREHPAVVDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG EEL LA DIETLYHEGEEFGKGPIIMISYADE AKVITWK+IDLPY
Sbjct: 121 LIDKGLIPMEGEEELKILAFDIETLYHEGEEFGKGPIIMISYADENEAKVITWKNIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKR +++IREKDPD+I+TYNGD+FDFPYL KRAEKLGIKL +GRD SEPK
Sbjct: 181 VEVVSSEREMIKRFLRIIREKDPDIIVTYNGDSFDFPYLAKRAEKLGIKLTIGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQR+GD AVE+KGRIHFDL+ VI RTINLPTYTLEAVYEAIFGK KEKVYA EIA+AWE
Sbjct: 241 MQRIGDMTAVEVKGRIHFDLYHVITRTINLPTYTLEAVYEAIFGKPKEKVYADEIAKAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
+G+ LERVAKYSMEDAK T+ELGKEF PME QL+RLVGQP+WDVSRSSTGNLVEWFLLRK
Sbjct: 301 SGENLERVAKYSMEDAKATYELGKEFLPMEIQLSRLVGQPLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNE+APNKP E EY+RRLRESY GG+VKEPEKGLWE IV LDFR+LYPSIIITHNVS
Sbjct: 361 AYERNEVAPNKPSEEEYQRRLRESYTGGFVKEPEKGLWENIVYLDFRALYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLN E CK YD+APQVGH+FCKD PGFIPSLLG+LLEERQKIK +MKE++DP+EK LL
Sbjct: 421 PDTLNLEGCKNYDIAPQVGHKFCKDIPGFIPSLLGHLLEERQKIKTKMKETQDPIEKILL 480
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQ+AIK+LANS+YGYYGYAKARWYCKECAESVTAWGR+YI+LV +ELE + GFKVLYI
Sbjct: 481 DYRQKAIKLLANSFYGYYGYAKARWYCKECAESVTAWGRKYIELVWKELEEKFGFKVLYI 540
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDGLYATIPG + EEIK+KAL+FV+YINSKLPGLLELEYEGFY RGFFVTKK+YA+IDE
Sbjct: 541 DTDGLYATIPGGESEEIKKKALEFVKYINSKLPGLLELEYEGFYKRGFFVTKKRYAVIDE 600
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
EGK++TRGLEIVRRDWSEIAKETQA+VLE ILKHG+V+EAV+IVKEV +KL+ YEIPPEK
Sbjct: 601 EGKVITRGLEIVRRDWSEIAKETQARVLETILKHGDVEEAVRIVKEVIQKLANYEIPPEK 660
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
L IYEQITRPL EYKAIGPHVAVAK+LAAKGVK+KPGMVIGYIVLRGDGPIS RAI EE
Sbjct: 661 LAIYEQITRPLHEYKAIGPHVAVAKKLAAKGVKIKPGMVIGYIVLRGDGPISNRAILAEE 720
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWL 769
+DPKKHKYDAEYYIENQVLPAV RIL FGYRKEDL+YQKT+QVGL +WL
Sbjct: 721 YDPKKHKYDAEYYIENQVLPAVLRILEGFGYRKEDLRYQKTRQVGLTSWL 770
>sp|P56689|DPOL_THEGO DNA POLYMERASE (TO POL) >gi|4699806|pdb|1TGO|A Chain A,
Thermostable B Type Dna Polymerase From Thermococcus
Gorgonarius
Length = 773
Score = 1337 bits (3423), Expect = 0.0
Identities = 639/771 (82%), Positives = 709/771 (91%), Gaps = 2/771 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITEDGKP+IRIFKKE GEFK++YDR F PYIYALLKDDSAI++VKKITAERHG
Sbjct: 1 MILDTDYITEDGKPVIRIFKKENGEFKIDYDRNFEPYIYALLKDDSAIEDVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
VR+ EKV+KKFLGRPIEVWKLY HPQDVPAIR+KI+EHPAVVDI+EYDIPFAKRY
Sbjct: 61 TTVRVVRAEKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKIKEHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIETLYHEGEEF +GPI+MISYADEEGA+VITWK+IDLPY
Sbjct: 121 LIDKGLIPMEGDEELKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKNIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
V+VVS+E+EMIKR +KV++EKDPDV+ITYNGDNFDF YL KR+EKLG+K LGR+ SEPK
Sbjct: 181 VDVVSTEKEMIKRFLKVVKEKDPDVLITYNGDNFDFAYLKKRSEKLGVKFILGREGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLEAVYEAIFG+ KEKVYA EIA+AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAIFGQPKEKVYAEEIAQAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TG+GLERVA+YSMEDAKVT+ELGKEFFPMEAQL+RLVGQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGEGLERVARYSMEDAKVTYELGKEFFPMEAQLSRLVGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDERE RR RESY GGYVKEPE+GLWE IV LDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDERELARR-RESYAGGYVKEPERGLWENIVYLDFRSLYPSIIITHNVS 419
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C+EYDVAPQVGH+FCKDFPGFIPSLLG+LLEERQK+KK+MK + DP+EKKLL
Sbjct: 420 PDTLNREGCEEYDVAPQVGHKFCKDFPGFIPSLLGDLLEERQKVKKKMKATIDPIEKKLL 479
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANS+YGYYGYAKARWYCKECAESVTAWGRQYI+ RE+E + GFKVLY
Sbjct: 480 DYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGRQYIETTIREIEEKFGFKVLYA 539
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDG +ATIPGA E +K+KA +F++YIN+KLPGLLELEYEGFY RGFFVTKKKYA+IDE
Sbjct: 540 DTDGFFATIPGADAETVKKKAKEFLDYINAKLPGLLELEYEGFYKRGFFVTKKKYAVIDE 599
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
E KI TRGLEIVRRDWSEIAKETQA+VLEAILKHG+V+EAV+IVKEVTEKLSKYE+PPEK
Sbjct: 600 EDKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEK 659
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVIYEQITR L +YKA GPHVAVAKRLAA+G+K++PG VI YIVL+G G I RAI +E
Sbjct: 660 LVIYEQITRDLKDYKATGPHVAVAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAIPFDE 719
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
FDP KHKYDAEYYIENQVLPAVERILRAFGYRKEDL+YQKT+QVGLGAWLK
Sbjct: 720 FDPAKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTRQVGLGAWLK 770
>sp|Q56366|DPOL_THES9 DNA POLYMERASE >gi|7434808|pir||S67920 DNA-directed DNA polymerase
(EC 2.7.7.7) - Thermococcus sp
>gi|1197452|gb|AAA88769.1| (U47108) DNA polymerase
[Thermococcus sp. 9oN-7]
Length = 775
Score = 1323 bits (3386), Expect = 0.0
Identities = 630/771 (81%), Positives = 706/771 (90%), Gaps = 2/771 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITE+GKP+IR+FKKE GEFK+EYDRTF PY YALLKDDSAI++VKK+TA+RHG
Sbjct: 1 MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
+V++ EKVQKKFLGRPIEVWKLY HPQDVPAIR++IR HPAVVDI+EYDIPFAKRY
Sbjct: 61 TVVKVKRAEKVQKKFLGRPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EELT LA DIETLYHEGEEFG GPI+MISYAD A+VITWK IDLPY
Sbjct: 121 LIDKGLIPMEGDEELTMLAFDIETLYHEGEEFGTGPILMISYADGSEARVITWKKIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
V+VVS+E+EMIKR ++V+REKDPDV+ITYNGDNFDF YL KR E+LGIK LGRD SEPK
Sbjct: 181 VDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFTLGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLEAVYEA+FGK KEKVYA EIA+AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
+G+GLERVA+YSMEDAKVT+ELG+EFFPMEAQL+RL+GQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 SGEGLERVARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AY+RNELAPNKPDERE RR R Y GGYVKEPE+GLW+ IV LDFRSLYPSIIITHNVS
Sbjct: 361 AYKRNELAPNKPDERELARR-RGGYAGGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVS 419
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE CKEYDVAP+VGH+FCKDFPGFIPSLLG+LLEERQKIK++MK + DP+EKKLL
Sbjct: 420 PDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQKIKRKMKATVDPLEKKLL 479
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANS+YGYYGYAKARWYCKECAESVTAWGR+YI++V RELE + GFKVLY
Sbjct: 480 DYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA 539
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDGL+ATIPGA E +K+KA +F++YIN KLPGLLELEYEGFY RGFFVTKKKYA+IDE
Sbjct: 540 DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDE 599
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
EGKI TRGLEIVRRDWSEIAKETQA+VLEAILKHG+V+EAV+IVKEVTEKLSKYE+PPEK
Sbjct: 600 EGKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEK 659
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVI+EQITR L +YKA GPHVAVAKRLAA+GVK++PG VI YIVL+G G I RAI +E
Sbjct: 660 LVIHEQITRDLRDYKATGPHVAVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPADE 719
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
FDP KH+YDAEYYIENQVLPAVERIL+AFGYRKEDL+YQKTKQVGLGAWLK
Sbjct: 720 FDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGLGAWLK 770
>pdb|1QHT|A Chain A, Dna Polymerase From Thermococcus Sp. 9on-7 Archaeon
Length = 775
Score = 1317 bits (3372), Expect = 0.0
Identities = 628/771 (81%), Positives = 704/771 (90%), Gaps = 2/771 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITE+GKP+IR+FKKE GEFK+EYDRTF PY YALLKDDSAI++VKK+TA+RHG
Sbjct: 1 MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
+V++ EKVQKKFLGRPIEVWKLY HPQDVPAIR++IR HPAVVDI+EYDIPFAKRY
Sbjct: 61 TVVKVKRAEKVQKKFLGRPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EELT LA I TLYHEGEEFG GPI+MISYAD A+VITWK IDLPY
Sbjct: 121 LIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGTGPILMISYADGSEARVITWKKIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
V+VVS+E+EMIKR ++V+REKDPDV+ITYNGDNFDF YL KR E+LGIK LGRD SEPK
Sbjct: 181 VDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFTLGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLEAVYEA+FGK KEKVYA EIA+AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
+G+GLERVA+YSMEDAKVT+ELG+EFFPMEAQL+RL+GQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 SGEGLERVARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AY+RNELAPNKPDERE RR R Y GGYVKEPE+GLW+ IV LDFRSLYPSIIITHNVS
Sbjct: 361 AYKRNELAPNKPDERELARR-RGGYAGGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVS 419
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE CKEYDVAP+VGH+FCKDFPGFIPSLLG+LLEERQKIK++MK + DP+EKKLL
Sbjct: 420 PDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQKIKRKMKATVDPLEKKLL 479
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANS+YGYYGYAKARWYCKECAESVTAWGR+YI++V RELE + GFKVLY
Sbjct: 480 DYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA 539
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDGL+ATIPGA E +K+KA +F++YIN KLPGLLELEYEGFY RGFFVTKKKYA+IDE
Sbjct: 540 DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDE 599
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
EGKI TRGLEIVRRDWSEIAKETQA+VLEAILKHG+V+EAV+IVKEVTEKLSKYE+PPEK
Sbjct: 600 EGKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEK 659
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVI+EQITR L +YKA GPHVAVAKRLAA+GVK++PG VI YIVL+G G I RAI +E
Sbjct: 660 LVIHEQITRDLRDYKATGPHVAVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPADE 719
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
FDP KH+YDAEYYIENQVLPAVERIL+AFGYRKEDL+YQKTKQVGLGAWLK
Sbjct: 720 FDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGLGAWLK 770
>pdb|1QQC|A Chain A, Crystal Structure Of An Archaebacterial Dna Polymerase
D.Tok
Length = 773
Score = 1314 bits (3362), Expect = 0.0
Identities = 623/771 (80%), Positives = 699/771 (89%), Gaps = 2/771 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITEDGKP+IR+FKKEKGEFK++YDR F PYIYALLKDDSAI+++KKITAERHG
Sbjct: 1 MILDADYITEDGKPVIRVFKKEKGEFKIDYDRDFEPYIYALLKDDSAIEDIKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
VR+T E+V+KKFLGRP+EVWKLY HPQDVPAIR+KIREHPAVVDI+EYDIPFAKRY
Sbjct: 61 TTVRVTRAERVKKKFLGRPVEVWKLYFTHPQDVPAIRDKIREHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LID+GL PMEG+EEL LA DIETLYHEGEEFG+GPI+MISYADEEGA+VITWK+IDLPY
Sbjct: 121 LIDRGLIPMEGDEELRMLAFDIETLYHEGEEFGEGPILMISYADEEGARVITWKNIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VE VS+E+EMIKR +KVI+EKDPDV+ITYNGDNFDF YL KR+E LG+K LGRD SEPK
Sbjct: 181 VESVSTEKEMIKRFLKVIQEKDPDVLITYNGDNFDFAYLKKRSEMLGVKFILGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLE VYE +FG+ KEKVYA EIA AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLETVYEPVFGQPKEKVYAEEIARAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
+G+GLERVA+YSMEDAK T+ELGKEFFPMEAQL+RLVGQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 SGEGLERVARYSMEDAKATYELGKEFFPMEAQLSRLVGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERN++APNKPDERE RR ESY GGYVKEPEKGLWE IV LD++SLYPSIIITHNVS
Sbjct: 361 AYERNDVAPNKPDERELARR-TESYAGGYVKEPEKGLWENIVYLDYKSLYPSIIITHNVS 419
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C+EYDVAPQVGHRFCKDFPGFIPSLLG+LLEERQK+KK+MK + DP+E+KLL
Sbjct: 420 PDTLNREGCREYDVAPQVGHRFCKDFPGFIPSLLGDLLEERQKVKKKMKATVDPIERKLL 479
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANSYYGYY YA ARWYC+ECAESVTAWGRQYI+ RE+E + GFKVLY
Sbjct: 480 DYRQRAIKILANSYYGYYAYANARWYCRECAESVTAWGRQYIETTMREIEEKFGFKVLYA 539
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDG +ATIPGA E +K KA +F+ YIN +LPGLLELEYEGFY RGFFVTKKKYA+IDE
Sbjct: 540 DTDGFFATIPGADAETVKNKAKEFLNYINPRLPGLLELEYEGFYRRGFFVTKKKYAVIDE 599
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
E KI TRGLEIVRRDWSEIAKETQA+VLEAILKHG+V+EAV+IVKEVTEKLS++E+PPEK
Sbjct: 600 EDKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSRHEVPPEK 659
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVIYEQITR L Y+A GPHVAVAKRLAA+G+K++PG VI YIVL+G G + RAI +E
Sbjct: 660 LVIYEQITRDLRSYRATGPHVAVAKRLAARGIKIRPGTVISYIVLKGPGRVGDRAIPFDE 719
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
FDP KH+YDAEYYIENQVLPAVERILRAFGYRKEDL+YQKTKQ GLGAWLK
Sbjct: 720 FDPAKHRYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTKQAGLGAWLK 770
>gb|AAA72101.1| (M74198) DNA dependent DNA polymerase [Thermococcus litoralis]
Length = 774
Score = 1239 bits (3170), Expect = 0.0
Identities = 590/773 (76%), Positives = 679/773 (87%), Gaps = 3/773 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYIT+DGKPIIRIFKKE GEFK+E D F+PYIYALLKDDSAI+E+K I ERHG
Sbjct: 1 MILDTDYITKDGKPIIRIFKKENGEFKIELDPHFQPYIYALLKDDSAIEEIKAIKGERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
K VR+ + KV+KKFLGR +EVWKL EHPQDVPA+R KIREHPAVVDI+EYDIPFAKRY
Sbjct: 61 KTVRVLDAVKVRKKFLGREVEVWKLIFEHPQDVPAMRGKIREHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIET YHEG+EFGKG IIMISYADEE A+VITWK+IDLPY
Sbjct: 121 LIDKGLIPMEGDEELKLLAFDIETFYHEGDEFGKGEIIMISYADEEEARVITWKNIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNS--E 238
V+VVS+EREMIKR V+V++EKDPDVIITYNGDNFD PYL+KRAEKLG++L LGRD E
Sbjct: 181 VDVVSNEREMIKRFVQVVKEKDPDVIITYNGDNFDLPYLIKRAEKLGVRLVLGRDKEHPE 240
Query: 239 PKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEA 298
PK+QRMGDS AVEIKGRIHFDLFPV+RRTINLPTYTLEAVYEA+ GK+K K+ A EIA
Sbjct: 241 PKIQRMGDSFAVEIKGRIHFDLFPVVRRTINLPTYTLEAVYEAVLGKTKSKLGAEEIAAI 300
Query: 299 WETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
WET + ++++A+YSMEDA+ T+ELGKEFFPMEA+LA+L+GQ VWDVSRSSTGNLVEW+LL
Sbjct: 301 WETEESMKKLAQYSMEDARATYELGKEFFPMEAELAKLIGQSVWDVSRSSTGNLVEWYLL 360
Query: 359 RKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHN 418
R AY RNELAPNKPDE EY+RRLR +Y GGYVKEPEKGLWE I+ LDFRSLYPSII+THN
Sbjct: 361 RVAYARNELAPNKPDEEEYKRRLRTTYLGGYVKEPEKGLWENIIYLDFRSLYPSIIVTHN 420
Query: 419 VSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKK 478
VSPDTL +E CK YDVAP VG+RFCKDFPGFIPS+LG+L+ RQ IKK+MK + DP+EKK
Sbjct: 421 VSPDTLEKEGCKNYDVAPIVGYRFCKDFPGFIPSILGDLIAMRQDIKKKMKSTIDPIEKK 480
Query: 479 LLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVL 537
+LDYRQRAIK+LANSYYGY GY KARWY KECAESVTAWGR YI++ RE+E + GFKVL
Sbjct: 481 MLDYRQRAIKLLANSYYGYMGYPKARWYSKECAESVTAWGRHYIEMTIREIEEKFGFKVL 540
Query: 538 YIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI 597
Y DTDG YATIPG K E IK+KA +F+ YINSKLPGLLELEYEGFY RGFFVTKK+YA+I
Sbjct: 541 YADTDGFYATIPGEKPELIKKKAKEFLNYINSKLPGLLELEYEGFYLRGFFVTKKRYAVI 600
Query: 598 DEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPP 657
DEEG+I TRGLE+VRRDWSEIAKETQAKVLEAILK G+V++AV++V++V EK++KY +P
Sbjct: 601 DEEGRITTRGLEVVRRDWSEIAKETQAKVLEAILKEGSVEKAVEVVRDVVEKIAKYRVPL 660
Query: 658 EKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAI 717
EKLVI+EQITR L +YKAIGPHVA+AKRLAA+G+KVKPG +I YIVL+G G IS R I +
Sbjct: 661 EKLVIHEQITRDLKDYKAIGPHVAIAKRLAARGIKVKPGTIISYIVLKGSGKISDRVILL 720
Query: 718 EEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
E+DP+KHKYD +YYIENQVLPAV RIL AFGYRKEDL+YQ +KQ GL AWLK
Sbjct: 721 TEYDPRKHKYDPDYYIENQVLPAVLRILEAFGYRKEDLRYQSSKQTGLDAWLK 773
>pdb|1D5A|A Chain A, Crystal Structure Of An Archaebacterial Dna Polymerase
D.Tok. Deposition Of Second Native Structure At 2.4
Angstro
Length = 733
Score = 1214 bits (3107), Expect = 0.0
Identities = 587/757 (77%), Positives = 657/757 (86%), Gaps = 25/757 (3%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITEDGKP+IR+FKKEKGEFK++YDR F PYIYALLKDDSAI+++KKITAERHG
Sbjct: 1 MILDADYITEDGKPVIRVFKKEKGEFKIDYDRDFEPYIYALLKDDSAIEDIKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
VR+T E+V+KKFLGRP+EVWKLY HPQDVPAIR+KIREHPAVVDI+EYDIPFAKRY
Sbjct: 61 TTVRVTRAERVKKKFLGRPVEVWKLYFTHPQDVPAIRDKIREHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LID+GL PMEG+EEL LA DIETL H G G GPI+MISYADEEGA+VITWK+IDLPY
Sbjct: 121 LIDRGLIPMEGDEELRMLAFDIETLAHAGAAAGAGPILMISYADEEGARVITWKNIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VE VS+E+EMIKR +KVI+EKDPDV+ITYNGDNFDF YL KR+E LG+K LGRD SEPK
Sbjct: 181 VESVSTEKEMIKRFLKVIQEKDPDVLITYNGDNFDFAYLKKRSEMLGVKFILGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLE VYE +FG+ EKVYA EIAEAW
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLETVYEPVFGQPAEKVYAEEIAEAWA 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
+G+GLERVA+YSMEDAK T+ELGKEFFPMEAQL+RLVGQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 SGEGLERVARYSMEDAKATYELGKEFFPMEAQLSRLVGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERN++APNKPDERE RR ESY GGYVKEPEKGLWE IV LD++SLYPSIIITHNVS
Sbjct: 361 AYERNDVAPNKPDERELARR-TESYAGGYVKEPEKGLWENIVYLDYKSLYPSIIITHNVS 419
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C+EYDVAPQVGHRFCKDFPGFIPSLLG+LLEERQK+KK+MK + DP+E+KLL
Sbjct: 420 PDTLNREGCREYDVAPQVGHRFCKDFPGFIPSLLGDLLEERQKVKKKMKATVDPIERKLL 479
Query: 481 DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYI 539
DYRQRAIKILANSYYGYY YA ARWYC+ECAESVTAWGRQYI+ RE+E + GFKVLY
Sbjct: 480 DYRQRAIKILANSYYGYYAYANARWYCRECAESVTAWGRQYIETTMREIEEKFGFKVLYA 539
Query: 540 DTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE 599
DTDG +ATIPGA E +K KA +F+ YIN +LPGLLELEYEGFY RGFFVTKKKYA+IDE
Sbjct: 540 DTDGFFATIPGADAETVKNKAKEFLNYINPRLPGLLELEYEGFYRRGFFVTKKKYAVIDE 599
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
E KI TRGLEIVRRDWSEIAKETQA+VLEAILKHG+V+EAV+IVKEVTEKLS++E+PPEK
Sbjct: 600 EDKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSRHEVPPEK 659
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEE 719
LVIYE GPHVA A VI YIVL+G G + RAI +E
Sbjct: 660 LVIYE-----------AGPHVAAA------------ATVISYIVLKGPGRVGDRAIPFDE 696
Query: 720 FDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLK 756
FDP KH+YDAEYYIENQVLPAVERILRAFGYRKEDL+
Sbjct: 697 FDPAKHRYDAEYYIENQVLPAVERILRAFGYRKEDLR 733
>sp|O59610|DPOL_PYRHO DNA POLYMERASE >gi|7446920|pir||C71210 probable DNA-directed DNA
polymerase - Pyrococcus horikoshii
>gi|3258391|dbj|BAA31074.1| (AP000007) 1235aa long
hypothetical DNA-directed DNA polymerase [Pyrococcus
horikoshii]
Length = 1235
Score = 957 bits (2447), Expect = 0.0
Identities = 462/493 (93%), Positives = 483/493 (97%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITEDGKPIIRIFKKE GEFKVEYDR FRPYIYALL+DDSAIDE+KKITA+RHG
Sbjct: 1 MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLRDDSAIDEIKKITAQRHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
K+VRI E EK+Q+KFLGRPIEVWKLYLEHPQDVPAIR+KIREHPAVVDIFEYDIPFAKRY
Sbjct: 61 KVVRIVETEKIQRKFLGRPIEVWKLYLEHPQDVPAIRDKIREHPAVVDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGLTPMEGNE+LTFLAVDIETLYHEGEEFGKGP+IMISYADEEGAKVITWK IDLPY
Sbjct: 121 LIDKGLTPMEGNEKLTFLAVDIETLYHEGEEFGKGPVIMISYADEEGAKVITWKKIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKRL++VI+EKDPDVIITYNGDNFDFPYLLKRAEKLGIKL LGRDNSEPK
Sbjct: 181 VEVVSSEREMIKRLIRVIKEKDPDVIITYNGDNFDFPYLLKRAEKLGIKLLLGRDNSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQ+MGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGK KEKVYA EIA+AWE
Sbjct: 241 MQKMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKPKEKVYADEIAKAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TG+GLERVAKYSMEDAKVT+ELG+EFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGEGLERVAKYSMEDAKVTYELGREFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDE+EYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEKEYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C+EYDVAP+VGHRFCKDFPGFIPSLLG LLEERQKIKKRMKESKDPVEKKLL
Sbjct: 421 PDTLNREGCEEYDVAPKVGHRFCKDFPGFIPSLLGQLLEERQKIKKRMKESKDPVEKKLL 480
Query: 481 DYRQRAIKILANS 493
DYRQRAIKILANS
Sbjct: 481 DYRQRAIKILANS 493
Score = 526 bits (1341), Expect = e-148
Identities = 251/280 (89%), Positives = 274/280 (97%), Gaps = 1/280 (0%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGA 551
NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELE+RGFKVLYIDTDGLYATIPG
Sbjct: 952 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELEARGFKVLYIDTDGLYATIPGV 1011
Query: 552 KH-EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI 610
K EE+K +AL+FV+YINSKLPG+LELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI
Sbjct: 1012 KDWEEVKRRALEFVDYINSKLPGVLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI 1071
Query: 611 VRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL 670
VRRDWSEIAKETQA+VLEAILKHGNV+EAVKIVK+VTEKL+ YE+PPEKLVIYEQITRP+
Sbjct: 1072 VRRDWSEIAKETQARVLEAILKHGNVEEAVKIVKDVTEKLTNYEVPPEKLVIYEQITRPI 1131
Query: 671 SEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAE 730
+EYKAIGPHVAVAKRL A+G+KVKPGMVIGYIVLRGDGPISKRAI+IEEFDP+KHKYDAE
Sbjct: 1132 NEYKAIGPHVAVAKRLMARGIKVKPGMVIGYIVLRGDGPISKRAISIEEFDPRKHKYDAE 1191
Query: 731 YYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
YYIENQVLPAVERIL+AFGY++EDL++QKTKQVGLGAW+K
Sbjct: 1192 YYIENQVLPAVERILKAFGYKREDLRWQKTKQVGLGAWIK 1231
>sp|Q51334|DPOL_PYRSD DNA POLYMERASE (DEEP VENT DNA POLYMERASE) [CONTAINS: PI-PSP I
ENDONUCLEASE] >gi|2129416|pir||S68593 DNA-directed DNA
polymerase (EC 2.7.7.7) Vent, intein containing
precursor - Pyrococcus sp >gi|825735|gb|AAA67130.1|
(U00707) Deep Vent DNA polymerase and PI-PspI precursor
[Pyrococcus sp.]
Length = 1312
Score = 912 bits (2330), Expect = 0.0
Identities = 439/493 (89%), Positives = 467/493 (94%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+DADYITEDGKPIIRIFKKE GEFKVEYDR FRPYIYALLKDDS IDEV+KITAERHG
Sbjct: 1 MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLKDDSQIDEVRKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVRI + EKV+KKFLGRPIEVW+LY EHPQDVPAIR+KIREH AV+DIFEYDIPFAKRY
Sbjct: 61 KIVRIIDAEKVRKKFLGRPIEVWRLYFEHPQDVPAIRDKIREHSAVIDIFEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIETLYHEGEEF KGPIIMISYADEE AKVITWK IDLPY
Sbjct: 121 LIDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEEAKVITWKKIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VEVVSSEREMIKR +KVIREKDPDVIITYNGD+FD PYL+KRAEKLGIKLPLGRD SEPK
Sbjct: 181 VEVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAEKLGIKLPLGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
MQR+GD AVEIKGRIHFDL+ VIRRTINLPTYTLEAVYEAIFGK KEKVYAHEIAEAWE
Sbjct: 241 MQRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TGKGLERVAKYSMEDAKVT+ELG+EFFPMEAQL+RLVGQP+WDVSRSSTGNLVEW+LLRK
Sbjct: 301 TGKGLERVAKYSMEDAKVTYELGREFFPMEAQLSRLVGQPLWDVSRSSTGNLVEWYLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDEREYERRLRESY GGYVKEPEKGLWEG+VSLDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDEREYERRLRESYAGGYVKEPEKGLWEGLVSLDFRSLYPSIIITHNVS 420
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE C+EYDVAP+VGH+FCKDFPGFIPSLL LL+ERQ+IK++MK SKDP+EKK+L
Sbjct: 421 PDTLNREGCREYDVAPEVGHKFCKDFPGFIPSLLKRLLDERQEIKRKMKASKDPIEKKML 480
Query: 481 DYRQRAIKILANS 493
DYRQRAIKILANS
Sbjct: 481 DYRQRAIKILANS 493
Score = 513 bits (1308), Expect = e-144
Identities = 251/279 (89%), Positives = 266/279 (94%), Gaps = 1/279 (0%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDTDGLYATIPG 550
NSYYGYYGYAKARWYCKECAESVTAWGR+YI+ VR+ELE + GFKVLYIDTDGLYATIPG
Sbjct: 1029 NSYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFGFKVLYIDTDGLYATIPG 1088
Query: 551 AKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI 610
AK EEIK+KAL+FV+YIN+KLPGLLELEYEGFY RGFFVTKKKYALIDEEGKI+TRGLEI
Sbjct: 1089 AKPEEIKKKALEFVDYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDEEGKIITRGLEI 1148
Query: 611 VRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL 670
VRRDWSEIAKETQAKVLEAILKHGNV+EAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL
Sbjct: 1149 VRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL 1208
Query: 671 SEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAE 730
EYKAIGPHVAVAKRLAA+GVKV+PGMVIGYIVLRGDGPISKRAI EEFD +KHKYDAE
Sbjct: 1209 HEYKAIGPHVAVAKRLAARGVKVRPGMVIGYIVLRGDGPISKRAILAEEFDLRKHKYDAE 1268
Query: 731 YYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWL 769
YYIENQVLPAV RIL AFGYRKEDL++QKTKQ GL AWL
Sbjct: 1269 YYIENQVLPAVLRILEAFGYRKEDLRWQKTKQTGLTAWL 1307
>emb|CAC12850.1| (AJ250333) DNA polymerase and endonucleases [Thermococcus sp. GE8]
Length = 1699
Score = 863 bits (2205), Expect = 0.0
Identities = 408/493 (82%), Positives = 454/493 (91%), Gaps = 1/493 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITEDGKP+IR+FKKE GEFK+EYDR F PY YALLKDDSAI+EVKKITA+RHG
Sbjct: 1 MILDTDYITEDGKPVIRVFKKENGEFKIEYDRNFEPYFYALLKDDSAIEEVKKITAKRHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
+V++ EKV+KKFLGRPIEVWKLY HPQDVPAIR+KIREHPAV+DI+EYDIPFAKRY
Sbjct: 61 TVVKVKRAEKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKIREHPAVIDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+E+L LA DIETLYHEGEEF +GPI+MISYADEEGA+VITWK +DLPY
Sbjct: 121 LIDKGLIPMEGDEKLKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKKVDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
V+VVS+E+EMIKR ++V++EKDPDV+ITYNGDNFDF YL +R+EKLG+K LGRD SEPK
Sbjct: 181 VDVVSTEKEMIKRFLRVVKEKDPDVLITYNGDNFDFAYLKRRSEKLGVKFILGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLEAVYEAIFGK KEKVYA EIA AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAIFGKPKEKVYAEEIATAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TG+GLERVA+YSMEDAKVTFELGKEFFPMEAQL+RL+GQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGEGLERVARYSMEDAKVTFELGKEFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVS 420
AYERNELAPNKPDERE RR R+SY GGYVKEPE+GLW IV LDFRSLYPSIIITHNVS
Sbjct: 361 AYERNELAPNKPDERELARR-RQSYAGGYVKEPERGLWNNIVYLDFRSLYPSIIITHNVS 419
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLL 480
PDTLNRE CKEYDVAPQVGH+FCKDFPGFIPSLLG+LLEERQKIK++M+ + DPVEKKLL
Sbjct: 420 PDTLNREGCKEYDVAPQVGHKFCKDFPGFIPSLLGDLLEERQKIKRKMRATIDPVEKKLL 479
Query: 481 DYRQRAIKILANS 493
DYRQRAIKILANS
Sbjct: 480 DYRQRAIKILANS 492
Score = 395 bits (1004), Expect = e-108
Identities = 190/235 (80%), Positives = 215/235 (90%)
Query: 536 VLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA 595
+L +TDG +ATIPGA E +K+KA++F++YIN+KLPGLLELEYEGFY RGFFVTKKKYA
Sbjct: 1460 ILVHNTDGFFATIPGADAETVKKKAMEFLKYINAKLPGLLELEYEGFYVRGFFVTKKKYA 1519
Query: 596 LIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 655
+IDEEGKI TRGLEIVRRDWSEIAKETQA+VLEAILKHG+V+EAV+IVKEVTEKLSKYE+
Sbjct: 1520 VIDEEGKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEV 1579
Query: 656 PPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAI 715
PPEKLVI+EQITR L +YKA GPHVAVAKRLAA+G+K++PG VI YIVL+G G I RAI
Sbjct: 1580 PPEKLVIHEQITRDLKDYKATGPHVAVAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAI 1639
Query: 716 AIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
+EFDP KHKYDAEYYIENQVLPAVERILRAFGYRKEDL+YQKTKQVGLGAWLK
Sbjct: 1640 PFDEFDPAKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTKQVGLGAWLK 1694
Score = 91.3 bits (223), Expect = 4e-17
Identities = 79/231 (34%), Positives = 114/231 (49%), Gaps = 40/231 (17%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDTDGLYATIPG 550
NSYYGYYGYAKARWYC+ECAESVTAWGR YI+ RE+E + GFKVLY D+ +
Sbjct: 1026 NSYYGYYGYAKARWYCRECAESVTAWGRSYIETTIREIEEKFGFKVLYADSVAGNTEVII 1085
Query: 551 AKHEEIK----EKALKFVEYINSKLPGLLELEY---EGFYARGFFVTKKKYALIDEEGKI 603
++ +++ EK + V+Y + E EY EG A +D G++
Sbjct: 1086 RRNGKVEFVPIEKLFQRVDY------RIGEKEYCALEGVEA----------LTLDNRGRL 1129
Query: 604 VTRGLEIVRRDWSEIAKETQAKVLEAILKHG---NVDEAVKIVKEVTEKLSKYEIP-PEK 659
V R + + R +T K+ + +V E ++ + K E P E+
Sbjct: 1130 VWRKVPYIMR------HKTNKKIYRVWFTNSWYLDVTEDHSLIGYLNTSKVKSEKPLKER 1183
Query: 660 LVIYEQITRPLSE--YKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDG 708
LV E R L E I + A+A+ + A + V+ +IG +V GDG
Sbjct: 1184 LV--EVKPRELGEKVKSLITLNRAIARSIKANPIAVRLWELIGLLV--GDG 1230
>sp|P30317|DPOL_THELI DNA POLYMERASE (VENT DNA POLYMERASE) [CONTAINS: PI-TLI I
ENDONUCLEASE; PI-TLI II ENDONUCLEASE]
>gi|543522|pir||S42459 DNA-directed DNA polymerase (EC
2.7.7.7) Vent, intein containing precursor -
Thermococcus litoralis >gi|154686|gb|AAA72100.1|
(M74198) DNA-dependent DNA polymerase precursor
[Thermococcus litoralis]
Length = 1702
Score = 806 bits (2060), Expect = 0.0
Identities = 383/495 (77%), Positives = 438/495 (88%), Gaps = 2/495 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYIT+DGKPIIRIFKKE GEFK+E D F+PYIYALLKDDSAI+E+K I ERHG
Sbjct: 1 MILDTDYITKDGKPIIRIFKKENGEFKIELDPHFQPYIYALLKDDSAIEEIKAIKGERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
K VR+ + KV+KKFLGR +EVWKL EHPQDVPA+R KIREHPAVVDI+EYDIPFAKRY
Sbjct: 61 KTVRVLDAVKVRKKFLGREVEVWKLIFEHPQDVPAMRGKIREHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIET YHEG+EFGKG IIMISYADEE A+VITWK+IDLPY
Sbjct: 121 LIDKGLIPMEGDEELKLLAFDIETFYHEGDEFGKGEIIMISYADEEEARVITWKNIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNS--E 238
V+VVS+EREMIKR V+V++EKDPDVIITYNGDNFD PYL+KRAEKLG++L LGRD E
Sbjct: 181 VDVVSNEREMIKRFVQVVKEKDPDVIITYNGDNFDLPYLIKRAEKLGVRLVLGRDKEHPE 240
Query: 239 PKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEA 298
PK+QRMGDS AVEIKGRIHFDLFPV+RRTINLPTYTLEAVYEA+ GK+K K+ A EIA
Sbjct: 241 PKIQRMGDSFAVEIKGRIHFDLFPVVRRTINLPTYTLEAVYEAVLGKTKSKLGAEEIAAI 300
Query: 299 WETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
WET + ++++A+YSMEDA+ T+ELGKEFFPMEA+LA+L+GQ VWDVSRSSTGNLVEW+LL
Sbjct: 301 WETEESMKKLAQYSMEDARATYELGKEFFPMEAELAKLIGQSVWDVSRSSTGNLVEWYLL 360
Query: 359 RKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHN 418
R AY RNELAPNKPDE EY+RRLR +Y GGYVKEPEKGLWE I+ LDFRSLYPSII+THN
Sbjct: 361 RVAYARNELAPNKPDEEEYKRRLRTTYLGGYVKEPEKGLWENIIYLDFRSLYPSIIVTHN 420
Query: 419 VSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKK 478
VSPDTL +E CK YDVAP VG+RFCKDFPGFIPS+LG+L+ RQ IKK+MK + DP+EKK
Sbjct: 421 VSPDTLEKEGCKNYDVAPIVGYRFCKDFPGFIPSILGDLIAMRQDIKKKMKSTIDPIEKK 480
Query: 479 LLDYRQRAIKILANS 493
+LDYRQRAIK+LANS
Sbjct: 481 MLDYRQRAIKLLANS 495
Score = 363 bits (922), Expect = 4e-99
Identities = 173/235 (73%), Positives = 205/235 (86%)
Query: 536 VLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA 595
+L +TDG YATIPG K E IK+KA +F+ YINSKLPGLLELEYEGFY RGFFVTKK+YA
Sbjct: 1467 ILVHNTDGFYATIPGEKPELIKKKAKEFLNYINSKLPGLLELEYEGFYLRGFFVTKKRYA 1526
Query: 596 LIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 655
+IDEEG+I TRGLE+VRRDWSEIAKETQAKVLEAILK G+V++AV++V++V EK++KY +
Sbjct: 1527 VIDEEGRITTRGLEVVRRDWSEIAKETQAKVLEAILKEGSVEKAVEVVRDVVEKIAKYRV 1586
Query: 656 PPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAI 715
P EKLVI+EQITR L +YKAIGPHVA+AKRLAA+G+KVKPG +I YIVL+G G IS R I
Sbjct: 1587 PLEKLVIHEQITRDLKDYKAIGPHVAIAKRLAARGIKVKPGTIISYIVLKGSGKISDRVI 1646
Query: 716 AIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
+ E+DP+KHKYD +YYIENQVLPAV RIL AFGYRKEDL+YQ +KQ GL AWLK
Sbjct: 1647 LLTEYDPRKHKYDPDYYIENQVLPAVLRILEAFGYRKEDLRYQSSKQTGLDAWLK 1701
Score = 84.3 bits (205), Expect = 5e-15
Identities = 51/125 (40%), Positives = 72/125 (56%), Gaps = 14/125 (11%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDTDGLYATIPG 550
NSYYGY GY KARWY KECAESVTAWGR YI++ RE+E + GFKVLY D ++ G
Sbjct: 1032 NSYYGYMGYPKARWYSKECAESVTAWGRHYIEMTIREIEEKFGFKVLYAD------SVSG 1085
Query: 551 AKHEEIKEKA-LKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYAL-IDEEGKIVTRGL 608
I++ ++FV K+ L + + + + AL +D++GK+V + +
Sbjct: 1086 ESEIIIRQNGKIRFV-----KIKDLFSKVDYSIGEKEYCILEGVEALTLDDDGKLVWKPV 1140
Query: 609 EIVRR 613
V R
Sbjct: 1141 PYVMR 1145
>emb|CAC18555.1| (AJ245819) DNA polymerase and endonucleases [Thermococcus
hydrothermalis]
Length = 1668
Score = 772 bits (1972), Expect = 0.0
Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 1/460 (0%)
Query: 34 FRPYIYALLKDDSAIDEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDV 93
F PYIYALLKDDSAI+EVKKITA RHG++V++ EKV+KKFLGRPIEVWKLY HPQDV
Sbjct: 1 FEPYIYALLKDDSAIEEVKKITAGRHGRVVKVKRAEKVKKKFLGRPIEVWKLYFTHPQDV 60
Query: 94 PAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFG 153
PAIR++IR H AVVDI+EYDIPFAKRYLIDKGL PMEG+EEL ++ DIETLYHEGEEFG
Sbjct: 61 PAIRDEIRRHSAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMMSFDIETLYHEGEEFG 120
Query: 154 KGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDN 213
GPI+MISYADE A+VITWK IDLPYVEVVS+E+EMIKR +KV++EKDPDV+ITYNGDN
Sbjct: 121 TGPILMISYADEGEARVITWKKIDLPYVEVVSTEKEMIKRFLKVVKEKDPDVLITYNGDN 180
Query: 214 FDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTY 273
FDF YL KR EK+GIK L RD SEPK+QRMGD AVE+KGRIHFDL+PVIRRTINLPTY
Sbjct: 181 FDFAYLKKRCEKIGIKFTLRRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTY 240
Query: 274 TLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQL 333
TLEAVYEA+FG KEKVY EI AWETG+GLERVA+YSMEDAKVT+ELG+EFFPMEAQL
Sbjct: 241 TLEAVYEAVFGTPKEKVYPEEITTAWETGEGLERVARYSMEDAKVTYELGREFFPMEAQL 300
Query: 334 ARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEP 393
+RL+GQ +WDVSRSSTGNLVEWFLLRKAYERNE+APNKPDERE RR R Y GGYVKEP
Sbjct: 301 SRLIGQSLWDVSRSSTGNLVEWFLLRKAYERNEIAPNKPDERELARR-RGGYAGGYVKEP 359
Query: 394 EKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSL 453
E+GLW+ IV LDF SLYPSIIITHNVSPDT NRE CKEYD APQVGH+FCKD GFIPSL
Sbjct: 360 ERGLWDNIVYLDFMSLYPSIIITHNVSPDTFNREGCKEYDTAPQVGHKFCKDVQGFIPSL 419
Query: 454 LGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANS 493
LG LL+ERQKIKKRMK S DP+EKKLLDYRQ+AIKILANS
Sbjct: 420 LGALLDERQKIKKRMKASIDPLEKKLLDYRQKAIKILANS 459
Score = 384 bits (977), Expect = e-105
Identities = 182/235 (77%), Positives = 214/235 (90%)
Query: 536 VLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA 595
+L +TDG +ATIPGA E +K+KA +F++YIN+KLPGLLELEYEGFY RGFFVTKKKYA
Sbjct: 1429 ILVHNTDGFFATIPGADAETVKKKAKEFLKYINAKLPGLLELEYEGFYVRGFFVTKKKYA 1488
Query: 596 LIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 655
+IDEEGKI TRGLEIVRRDWSEIAKETQA+VLEAIL+HG+V+EAV+IVK+VTEKLSKYE+
Sbjct: 1489 VIDEEGKITTRGLEIVRRDWSEIAKETQARVLEAILRHGDVEEAVRIVKDVTEKLSKYEV 1548
Query: 656 PPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAI 715
PPEKLVI+EQITR L +YKA GPHVA+AKRLAA+G+K++PG VI YIVL+G G I RAI
Sbjct: 1549 PPEKLVIHEQITRELKDYKATGPHVAIAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAI 1608
Query: 716 AIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
+EFDP KH+YDAEYYIENQVLPAVERIL+AFGY+KE+L+YQKT+QVGLGAWLK
Sbjct: 1609 PFDEFDPTKHRYDAEYYIENQVLPAVERILKAFGYKKEELRYQKTRQVGLGAWLK 1663
Score = 89.7 bits (219), Expect = 1e-16
Identities = 74/230 (32%), Positives = 109/230 (47%), Gaps = 38/230 (16%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDTDGLYATIPG 550
NSYYGYYGYA+ARWYCKECAESVTAWGR YI+ E+E R GFKVLY D ++ G
Sbjct: 995 NSYYGYYGYARARWYCKECAESVTAWGRDYIETTIHEIEERFGFKVLYAD------SVTG 1048
Query: 551 AKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYAL--------IDEEGK 602
IK VE++ + E F + + +K+Y + +D G+
Sbjct: 1049 ETEIIIKRNGK--VEFVAIE---------ELFQRVDYRIGEKEYCVLEGVEALTLDNRGR 1097
Query: 603 IVTRGLEIVRRDWSEIAKETQAKVLEAILKHG---NVDEAVKIVKEV-TEKLSKYEIPPE 658
+V + + V R T ++ + +V E ++ + T K+ + E
Sbjct: 1098 LVWKSVPYVMR------HRTNKRIYRVWFTNSWYLDVTEDHSLIGYMNTSKVKPGKPLKE 1151
Query: 659 KLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDG 708
+LV + S I P+ A+A + + VK +IG +V GDG
Sbjct: 1152 RLVEVKPGELGESVKSLITPNRAIAHGIRVNPIAVKLWELIGLLV--GDG 1199
>dbj|BAA06142.2| (D29671) DNA-dependent DNA polymerase [Pyrococcus sp.]
Length = 1671
Score = 706 bits (1803), Expect = 0.0
Identities = 333/407 (81%), Positives = 370/407 (90%), Gaps = 1/407 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITEDGKP+IRIFKKE GEFK+EYDRTF PY YALLKDDSAI+EVKKITAERHG
Sbjct: 1 MILDTDYITEDGKPVIRIFKKENGEFKIEYDRTFEPYFYALLKDDSAIEEVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
+V + VEKVQKKFLGRP+EVWKLY HPQDVPAIR+KIREHPAV+DI+EYDIPFAKRY
Sbjct: 61 TVVTVKRVEKVQKKFLGRPVEVWKLYFTHPQDVPAIRDKIREHPAVIDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIETLYHEGEEF +GPI+MISYADEEGA+VITWK++DLPY
Sbjct: 121 LIDKGLVPMEGDEELKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKNVDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
V+VVS+EREMIKR ++V++EKDPDV+ITYNGDNFDF YL KR EKLGI LGRD SEPK
Sbjct: 181 VDVVSTEREMIKRFLRVVKEKDPDVLITYNGDNFDFAYLKKRCEKLGINFALGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLEAVYEA+FG+ KEKVYA EI AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGQPKEKVYAEEITTAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TG+ LERVA+YSMEDAKVT+ELGKEF PMEAQL+RL+GQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGENLERVARYSMEDAKVTYELGKEFLPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFR 407
AYERNELAPNKPDE+E RR R+SYEGGYVKEPE+GLWE IV LDFR
Sbjct: 361 AYERNELAPNKPDEKELARR-RQSYEGGYVKEPERGLWENIVYLDFR 406
Score = 466 bits (1186), Expect = e-130
Identities = 221/280 (78%), Positives = 253/280 (89%), Gaps = 1/280 (0%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDTDGLYATIPG 550
NSYYGYYGYA+ARWYCKECAESVTAWGR+YI + +E+E + GFKV+Y DTDG +ATIPG
Sbjct: 1388 NSYYGYYGYARARWYCKECAESVTAWGREYITMTIKEIEEKYGFKVIYSDTDGFFATIPG 1447
Query: 551 AKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI 610
A E +K+KA++F++YIN+KLPG LELEYEGFY RGFFVTKKKYA+IDEEGKI TRGLEI
Sbjct: 1448 ADAETVKKKAMEFLKYINAKLPGALELEYEGFYKRGFFVTKKKYAVIDEEGKITTRGLEI 1507
Query: 611 VRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL 670
VRRDWSEIAKETQA+VLEA+LK G+V++AV+IVKEVTEKLSKYE+PPEKLVI+EQITR L
Sbjct: 1508 VRRDWSEIAKETQARVLEALLKDGDVEKAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDL 1567
Query: 671 SEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAE 730
+YKA GPHVAVAKRLAA+GVK++PG VI YIVL+G G I RAI +EFDP KHKYDAE
Sbjct: 1568 KDYKATGPHVAVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPFDEFDPTKHKYDAE 1627
Query: 731 YYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
YYIENQVLPAVERILRAFGYRKEDL+YQKT+QVGL AWLK
Sbjct: 1628 YYIENQVLPAVERILRAFGYRKEDLRYQKTRQVGLSAWLK 1667
Score = 166 bits (416), Expect = 9e-40
Identities = 79/90 (87%), Positives = 84/90 (92%)
Query: 404 LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQK 463
L SLYPSIIITHNVSPDTLNRE CKEYDVAPQVGHRFCKDFPGFIPSLLG+LLEERQK
Sbjct: 763 LTHNSLYPSIIITHNVSPDTLNREGCKEYDVAPQVGHRFCKDFPGFIPSLLGDLLEERQK 822
Query: 464 IKKRMKESKDPVEKKLLDYRQRAIKILANS 493
IKK+MK + DP+E+KLLDYRQRAIKILANS
Sbjct: 823 IKKKMKATIDPIERKLLDYRQRAIKILANS 852
>pir||S71551 DNA-directed DNA polymerase (EC 2.7.7.7) KOD, intein containing
precursor - Pyrococcus sp. (strain KOD1)
Length = 1670
Score = 702 bits (1791), Expect = 0.0
Identities = 331/407 (81%), Positives = 369/407 (90%), Gaps = 1/407 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITEDGKP+IRIFKKE GEFK+EYDRTF PY YALLKDDSAI+EVKKITAERHG
Sbjct: 1 MILDTDYITEDGKPVIRIFKKENGEFKIEYDRTFEPYFYALLKDDSAIEEVKKITAERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
+V + VEKVQKKFLGRP+EVWKLY HPQDVPAIR+KIREH AV+DI+EYDIPFAKRY
Sbjct: 61 TVVTVKRVEKVQKKFLGRPVEVWKLYFTHPQDVPAIRDKIREHGAVIDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DI+TLYHEGEEF +GPI+MISYADEEGA+VITWK++DLPY
Sbjct: 121 LIDKGLVPMEGDEELKMLAFDIQTLYHEGEEFAEGPILMISYADEEGARVITWKNVDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
V+VVS+EREMIKR ++V++EKDPDV+ITYNGDNFDF YL KR EKLGI LGRD SEPK
Sbjct: 181 VDVVSTEREMIKRFLRVVKEKDPDVLITYNGDNFDFAYLKKRCEKLGINFALGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIRRTINLPTYTLEAVYEA+FG+ KEKVYA EI AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGQPKEKVYAEEITPAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TG+ LERVA+YSMEDAKVT+ELGKEF PMEAQL+RL+GQ +WDVSRSSTGNLVEWFLLRK
Sbjct: 301 TGENLERVARYSMEDAKVTYELGKEFLPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFR 407
AYERNELAPNKPDE+E RR R+SYEGGYVKEPE+GLWE IV LDFR
Sbjct: 361 AYERNELAPNKPDEKELARR-RQSYEGGYVKEPERGLWENIVYLDFR 406
Score = 466 bits (1185), Expect = e-130
Identities = 221/280 (78%), Positives = 252/280 (89%), Gaps = 1/280 (0%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDTDGLYATIPG 550
NSYYGYYGYA+ARWYCKECAESVTAWGR+YI + +E+E + GFKV+Y DTDG +ATIPG
Sbjct: 1387 NSYYGYYGYARARWYCKECAESVTAWGREYITMTIKEIEEKYGFKVIYSDTDGFFATIPG 1446
Query: 551 AKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI 610
A E +K+KA++F+ YIN+KLPG LELEYEGFY RGFFVTKKKYA+IDEEGKI TRGLEI
Sbjct: 1447 ADAETVKKKAMEFLNYINAKLPGALELEYEGFYKRGFFVTKKKYAVIDEEGKITTRGLEI 1506
Query: 611 VRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL 670
VRRDWSEIAKETQA+VLEA+LK G+V++AV+IVKEVTEKLSKYE+PPEKLVI+EQITR L
Sbjct: 1507 VRRDWSEIAKETQARVLEALLKDGDVEKAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDL 1566
Query: 671 SEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAE 730
+YKA GPHVAVAKRLAA+GVK++PG VI YIVL+G G I RAI +EFDP KHKYDAE
Sbjct: 1567 KDYKATGPHVAVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPFDEFDPTKHKYDAE 1626
Query: 731 YYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
YYIENQVLPAVERILRAFGYRKEDL+YQKT+QVGL AWLK
Sbjct: 1627 YYIENQVLPAVERILRAFGYRKEDLRYQKTRQVGLSAWLK 1666
Score = 166 bits (416), Expect = 9e-40
Identities = 79/90 (87%), Positives = 84/90 (92%)
Query: 404 LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQK 463
L SLYPSIIITHNVSPDTLNRE CKEYDVAPQVGHRFCKDFPGFIPSLLG+LLEERQK
Sbjct: 763 LTHNSLYPSIIITHNVSPDTLNREGCKEYDVAPQVGHRFCKDFPGFIPSLLGDLLEERQK 822
Query: 464 IKKRMKESKDPVEKKLLDYRQRAIKILANS 493
IKK+MK + DP+E+KLLDYRQRAIKILANS
Sbjct: 823 IKKKMKATIDPIERKLLDYRQRAIKILANS 852
>sp|P74918|DPOL_THEFM DNA POLYMERASE (POL TFU) >gi|1655695|emb|CAA93738.1| (Z69882) DNA
polymerase and endonuclease [Thermococcus fumicolans]
Length = 1523
Score = 692 bits (1767), Expect = 0.0
Identities = 329/407 (80%), Positives = 365/407 (88%), Gaps = 1/407 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYITEDG+P+IR+FKKE GEFK+EYDR F PYIYALLKDDSAI++VKKITA RHG
Sbjct: 1 MILDTDYITEDGRPVIRVFKKENGEFKIEYDRDFEPYIYALLKDDSAIEDVKKITASRHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
VR+ KV+KKFLGRPIEVWKLY HPQDVPAIR+KIREHPAVVDI+EYDIPFAKRY
Sbjct: 61 TTVRVVRAGKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKIREHPAVVDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL LA DIETLYHEGEEF +GPI+MISYADEEGA+VITWK IDLPY
Sbjct: 121 LIDKGLIPMEGDEELKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKKIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
V+VVS+E+EMIKR +KV++EKDPDV+ITYNGDNFDF YL KR+EKLG+K LGRD SEPK
Sbjct: 181 VDVVSTEKEMIKRFLKVVKEKDPDVLITYNGDNFDFAYLKKRSEKLGVKFILGRDGSEPK 240
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
+QRMGD AVE+KGRIHFDL+PVIR TINLPTYTLEAVYEAIFG+ KEKVYA EIA+AWE
Sbjct: 241 IQRMGDRFAVEVKGRIHFDLYPVIRHTINLPTYTLEAVYEAIFGQPKEKVYAEEIAQAWE 300
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRK 360
TG+GLERVA+YSMEDAKVT+ELG+EFFPMEAQL+RLVGQ WDVSRSSTGNLVEW+LLRK
Sbjct: 301 TGEGLERVARYSMEDAKVTYELGREFFPMEAQLSRLVGQSFWDVSRSSTGNLVEWYLLRK 360
Query: 361 AYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFR 407
AYERNELAPNKP RE ERR R Y GGYVKEPE+GLWE I LDFR
Sbjct: 361 AYERNELAPNKPSGRELERR-RGGYAGGYVKEPERGLWENIAYLDFR 406
Score = 384 bits (976), Expect = e-105
Identities = 183/235 (77%), Positives = 211/235 (88%)
Query: 536 VLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA 595
+L +TDG +ATIPGA E +K+KA +F+ YIN KLPGLLELEYEGFY RGFFVTKKKYA
Sbjct: 1285 ILVHNTDGFFATIPGADAETVKKKAREFLNYINPKLPGLLELEYEGFYRRGFFVTKKKYA 1344
Query: 596 LIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 655
+IDEEGKI TRGLEIVRRDWSE+AKETQA+VLEAIL+HG+V+EAV+IVKEVTEKLSKYE+
Sbjct: 1345 VIDEEGKITTRGLEIVRRDWSEVAKETQARVLEAILRHGDVEEAVRIVKEVTEKLSKYEV 1404
Query: 656 PPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAI 715
PPEKLVI+EQITR L +YKA GPHVA+AKRLAA+G+KV+PG VI YIVL+G G I R I
Sbjct: 1405 PPEKLVIHEQITRELKDYKATGPHVAIAKRLAARGIKVRPGTVISYIVLKGSGRIGDRTI 1464
Query: 716 AIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
+EFDP KH+YDAEYYIENQVLPAVERIL+AFGY+KEDL+YQKT+QVGLGAWLK
Sbjct: 1465 PFDEFDPTKHRYDAEYYIENQVLPAVERILKAFGYKKEDLRYQKTRQVGLGAWLK 1519
Score = 243 bits (613), Expect = 7e-63
Identities = 113/139 (81%), Positives = 124/139 (88%), Gaps = 1/139 (0%)
Query: 404 LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQK 463
L SLYPSIII+HNVSPDTLNRE C EYD APQVGHRFCKDFPGFIPSLLG+LL+ERQK
Sbjct: 763 LTHNSLYPSIIISHNVSPDTLNREGCGEYDEAPQVGHRFCKDFPGFIPSLLGDLLDERQK 822
Query: 464 IKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYID 523
+KK MK + DP+EKKLLDYRQRAIKILANS+YGYYGYAKARWYCKECAESVTAWGRQYI+
Sbjct: 823 VKKHMKATVDPIEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGRQYIE 882
Query: 524 LVRRELESR-GFKVLYIDT 541
RE+E + GFKVLY D+
Sbjct: 883 TTMREIEEKFGFKVLYADS 901
>sp|O33845|DPOL_THEST DNA POLYMERASE >gi|2293389|emb|CAA73475.1| (Y13030) DNA-directed
DNA polymerase [Thermococcus sp.]
Length = 1829
Score = 665 bits (1696), Expect = 0.0
Identities = 315/409 (77%), Positives = 360/409 (88%), Gaps = 2/409 (0%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
MI+D DYIT+DGKPIIRIFKKE GEFK+E D F+PYIYALLKDDSAIDE+K I ERHG
Sbjct: 1 MILDTDYITKDGKPIIRIFKKENGEFKIELDPHFQPYIYALLKDDSAIDEIKAIKGERHG 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
KIVR+ + KV+KKFLGR +EVWKL EHPQDVPA+R KIREHPAV+DI+EYDIPFAKRY
Sbjct: 61 KIVRVVDAVKVKKKFLGRDVEVWKLIFEHPQDVPALRGKIREHPAVIDIYEYDIPFAKRY 120
Query: 121 LIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPY 180
LIDKGL PMEG+EEL +A DIET YHEG+EFGKG IIMISYADEE A+VITWK+IDLPY
Sbjct: 121 LIDKGLIPMEGDEELKLMAFDIETFYHEGDEFGKGEIIMISYADEEEARVITWKNIDLPY 180
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD--NSE 238
V+VVS+EREMIKR V+++REKDPDV+ITYNGDNFD PYL+KRAEKLG+ L LGRD + E
Sbjct: 181 VDVVSNEREMIKRFVQIVREKDPDVLITYNGDNFDLPYLIKRAEKLGVTLLLGRDKEHPE 240
Query: 239 PKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEA 298
PK+ RMGDS AVEIKGRIHFDLFPV+RRTINLPTYTLEAVYEA+ GK+K K+ A EIA
Sbjct: 241 PKIHRMGDSFAVEIKGRIHFDLFPVVRRTINLPTYTLEAVYEAVLGKTKSKLGAEEIAAI 300
Query: 299 WETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
WET + ++++A+YSMEDA+ T+ELGKEFFPMEA+LA+L+GQ VWDVSRSSTGNLVEW+LL
Sbjct: 301 WETEESMKKLAQYSMEDARATYELGKEFFPMEAELAKLIGQSVWDVSRSSTGNLVEWYLL 360
Query: 359 RKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFR 407
R AYERNELAPNKPDE EY RRLR +Y GGYVKEPE+GLWE I LDFR
Sbjct: 361 RVAYERNELAPNKPDEEEYRRRLRTTYLGGYVKEPERGLWENIAYLDFR 409
Score = 367 bits (933), Expect = e-100
Identities = 177/235 (75%), Positives = 207/235 (87%)
Query: 536 VLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA 595
+L +TDG YATIPG K E IK+KA +F++YINSKLPGLLELEYEGFY RGFFV KK+YA
Sbjct: 1594 ILVHNTDGFYATIPGEKPETIKKKAKEFLKYINSKLPGLLELEYEGFYLRGFFVAKKRYA 1653
Query: 596 LIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 655
+IDEEG+I TRGLE+VRRDWSEIAKETQAKVLEAILK +V++AV+IVK+V E+++KY++
Sbjct: 1654 VIDEEGRITTRGLEVVRRDWSEIAKETQAKVLEAILKEDSVEKAVEIVKDVVEEIAKYQV 1713
Query: 656 PPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAI 715
P EKLVI+EQIT+ LSEYKAIGPHVA+AKRLAAKG+KV+PG +I YIVLRG G IS R I
Sbjct: 1714 PLEKLVIHEQITKDLSEYKAIGPHVAIAKRLAAKGIKVRPGTIISYIVLRGSGKISDRVI 1773
Query: 716 AIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGLGAWLK 770
+ E+DPKKHKYD +YYIENQVLPAV RIL AFGYRKEDLKYQ +KQVGL AWLK
Sbjct: 1774 LLSEYDPKKHKYDPDYYIENQVLPAVLRILEAFGYRKEDLKYQSSKQVGLDAWLK 1828
Score = 145 bits (363), Expect = 1e-33
Identities = 66/90 (73%), Positives = 78/90 (86%)
Query: 404 LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQK 463
L SLYPSII+THNVSPDTL RE CK YDVAP VG++FCKDFPGFIPS+LG L+ RQ+
Sbjct: 766 LTHNSLYPSIIVTHNVSPDTLEREGCKNYDVAPIVGYKFCKDFPGFIPSILGELITMRQE 825
Query: 464 IKKRMKESKDPVEKKLLDYRQRAIKILANS 493
IKK+MK + DP+EKK+LDYRQRA+K+LANS
Sbjct: 826 IKKKMKATIDPIEKKMLDYRQRAVKLLANS 855
Score = 82.3 bits (200), Expect = 2e-14
Identities = 36/51 (70%), Positives = 42/51 (81%), Gaps = 1/51 (1%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDT 541
NSYYGY GY KARWY KECAESVTAWGR YI++ +E+E + GFKVLY D+
Sbjct: 1392 NSYYGYMGYPKARWYSKECAESVTAWGRHYIEMTIKEIEEKFGFKVLYADS 1442
>sp|P52025|DPOL_METVO DNA POLYMERASE >gi|495654|gb|AAA72443.1| (L33366) DNA polymerase
[Methanococcus voltae]
Length = 824
Score = 510 bits (1300), Expect = e-143
Identities = 290/737 (39%), Positives = 437/737 (58%), Gaps = 70/737 (9%)
Query: 65 ITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDK 124
I+EV + K + ++ K+Y+++P V IRE +E +E+DIPF +RY+ID+
Sbjct: 101 ISEVSDFKNK---KERKICKVYVKYPNHVKIIREYFKEFGKS---YEFDIPFLRRYMIDQ 154
Query: 125 GLTPM----EGNE------ELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWK 174
+ P E N+ EL +A D+E + K PIIM++ ++ KVIT+K
Sbjct: 155 DIVPSAKYSEDNKIDNSIPELNCIAFDMELYCKKEPNAKKDPIIMVNLFSKDYQKVITYK 214
Query: 175 SIDLPY----VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL 230
+ V+ V E+E+I++ ++++++ D VI TYNGDNFDFPYL KRA I+L
Sbjct: 215 KFENSEYNGCVDYVKDEKELIQKTIEILKQYD--VIYTYNGDNFDFPYLKKRANIYEIEL 272
Query: 231 PLGR--DNSEP---KMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGK 285
++ +P K+ + G + +I G IH DL+P+ R+ +NL Y LE V + +F
Sbjct: 273 DFDNASNSQQPQIIKISKGGINRKSKIPGIIHIDLYPIARKLLNLTKYKLENVVQELFKI 332
Query: 286 SKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVS 345
+KE V +I + WET + +Y+ EDA T+++G F P+E +R+V QP++D S
Sbjct: 333 NKEAVDYGDIPKMWETED--TTLLRYAYEDALYTYKMGNYFLPLEIMFSRIVNQPLYDTS 390
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLD 405
R ++ +VE+ LL++++E+N ++PN+P Y R + SYEGGYV+EP KG+ E IVSLD
Sbjct: 391 RMNSSQMVEFLLLKRSFEQNMISPNRPSSSSYRERAKFSYEGGYVREPLKGIQEDIVSLD 450
Query: 406 FRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIK 465
F SLYPSI+I+HN+SP+T+ E + ++ G IP L LL R+ IK
Sbjct: 451 FMSLYPSILISHNISPETVIYEEKERENMEL-----------GIIPKTLNELLSRRKHIK 499
Query: 466 KRMKE----SKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQY 521
+K+ ++ E L++ Q++IK+LANS+YGY + ARWY +CAE VT GR+Y
Sbjct: 500 MLLKDKIQKNEFDEEYSRLEHEQKSIKVLANSHYGYLAFPMARWYSDKCAEMVTGLGRKY 559
Query: 522 IDLVRRELESRGFKVLYIDTDGLYA----------------------TIPGAKHEEIKEK 559
I + E GFKV+Y DTDG YA +P EE+
Sbjct: 560 IQETIEKAEEFGFKVIYADTDGFYAKWDYDKLQKGKKEENDKSDKLSNLPKLSKEELIIL 619
Query: 560 ALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIA 619
KF++ IN +LP +ELE+EG + RG FVTKKKYALI+++G IV +GLE+VRRDWS IA
Sbjct: 620 TKKFLKGINEELPEGMELEFEGHFKRGLFVTKKKYALIEDDGHIVVKGLEVVRRDWSNIA 679
Query: 620 KETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPH 679
K+TQ V+ A+L+ G+V+ A KI+K + L K I L+I+ Q+T+ + EYK+ PH
Sbjct: 680 KDTQQAVIRALLEDGDVNLAKKIIKNTIDNLKKGNIDKNDLLIHTQLTKNIEEYKSTAPH 739
Query: 680 VAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLP 739
+ VAK++ +G V+ G VI YI+++G IS+RA +E YD YYI+NQVLP
Sbjct: 740 IEVAKKIKQRGDSVRVGDVISYIIVKGSRSISERAELLE----YAGDYDINYYIDNQVLP 795
Query: 740 AVERILRAFGYRKEDLK 756
V RI+ + G +++LK
Sbjct: 796 PVIRIMESLGISEDELK 812
>gi|11498108 DNA polymerase B1 (polB) [Archaeoglobus fulgidus]
>gi|3122019|sp|O29753|DPOL_ARCFU DNA POLYMERASE
>gi|7434809|pir||A69312 DNA polymerase B1 (polB) homolog
- Archaeoglobus fulgidus >gi|2650130|gb|AAB90741.1|
(AE001070) DNA polymerase B1 (polB) [Archaeoglobus
fulgidus]
Length = 781
Score = 501 bits (1276), Expect = e-140
Identities = 297/800 (37%), Positives = 450/800 (56%), Gaps = 83/800 (10%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHGK 61
+IDADY T GK ++R++ K+ V YD F PY Y + D+ D +K +
Sbjct: 8 LIDADYETIGGKAVVRLWCKDDQGIFVAYDYNFDPYFYVIGVDE---DILKNAATSTRRE 64
Query: 62 IVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYL 121
++++ EK Q K LGR +E + +Y HPQ VP +R+ + + D+ E DIPFA RYL
Sbjct: 65 VIKLKSFEKAQLKTLGREVEGYIVYAHHPQHVPKLRDYLSQFG---DVREADIPFAYRYL 121
Query: 122 IDKGLTPMEGNE---------------------------ELTFLAVDIETLYHEG-EEFG 153
IDK L M+G EL L D E L G E
Sbjct: 122 IDKDLACMDGIAIEGEKQGGVIRSYKIEKVERIPRMEFPELKMLVFDCEMLSSFGMPEPE 181
Query: 154 KGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDN 213
K PII+IS + ++I + ER++I VK+I+ DPD+I+ YN D
Sbjct: 182 KDPIIVISVKTNDDDEII-----------LTGDERKIISDFVKLIKSYDPDIIVGYNQDA 230
Query: 214 FDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTY 273
FD+PYL KRAE+ I L +GRD S + +I GR++ DL+ + R ++
Sbjct: 231 FDWPYLRKRAERWNIPLDVGRDGSNVVFR----GGRPKITGRLNVDLYDIAMRISDIKIK 286
Query: 274 TLEAVYEAIFGKSK-EKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQ 332
LE V E + K + + A +I W G+ E+V Y+ +DA T+ + KE PM +
Sbjct: 287 KLENVAEFLGTKIEIADIEAKDIYRYWSRGEK-EKVLNYARQDAINTYLIAKELLPMHYE 345
Query: 333 LARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKE 392
L++++ PV DV+R G V+W LL +A + E+APN P+ E SYEG +V E
Sbjct: 346 LSKMIRLPVDDVTRMGRGKQVDWLLLSEAKKIGEIAPNPPEHAE-------SYEGAFVLE 398
Query: 393 PEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLN-RENCKEYDVAPQVGHRFCKDFPGFIP 451
PE+GL E + LDF S+YPSI+I N+SPDT R++C E AP+VGH+F K GF
Sbjct: 399 PERGLHENVACLDFASMYPSIMIAFNISPDTYGCRDDCYE---APEVGHKFRKSPDGFFK 455
Query: 452 SLLGNLLEERQKIKKRMKE-SKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKEC 510
+L L+E+R+++K +K S + E KLLD +Q+ +K+L NS+YGY G+ ARWYC C
Sbjct: 456 RILRMLIEKRRELKVELKNLSPESSEYKLLDIKQQTLKVLTNSFYGYMGWNLARWYCHPC 515
Query: 511 AESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSK 570
AE+ TAWGR +I + ES GFKVLY DTD ++ T G E++ + ++ ++ +
Sbjct: 516 AEATTAWGRHFIRTSAKIAESMGFKVLYGDTDSIFVTKAGMTKEDVD----RLIDKLHEE 571
Query: 571 LPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAI 630
LP +++E + +Y+ FFV KK+YA + E+G++V +GLE+ R DW E+AK+ Q +V+E I
Sbjct: 572 LP--IQIEVDEYYSAIFFVEKKRYAGLTEDGRLVVKGLEVRRGDWCELAKKVQREVIEVI 629
Query: 631 LKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKG 690
LK N ++A+ +VK+V ++ + ++ E++VIY+ +T+ S+Y+++ HV A + G
Sbjct: 630 LKEKNPEKALSLVKDVILRIKEGKVSLEEVVIYKGLTKKPSKYESMQAHVKAALKAREMG 689
Query: 691 VKVKPGMVIGYIVLRGDGPISKRAI---AIEEFDPKK-----------HKYDAEYYIENQ 736
+ IGY++++G G I RA IE+FD + K D +YYI+NQ
Sbjct: 690 IIYPVSSKIGYVIVKGSGNIGDRAYPIDLIEDFDGENLRIKTKSGIEIKKLDKDYYIDNQ 749
Query: 737 VLPAVERILRAFGYRKEDLK 756
++P+V RIL FGY + LK
Sbjct: 750 IIPSVLRILERFGYTEASLK 769
>sp|O27276|DPOL_METTH DNA POLYMERASE >gi|7482291|pir||C69028 DNA-dependent DNA polymerase
family B (PolB1) - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622317|gb|AAB85697.1| (AE000888)
DNA-dependent DNA polymerase family B (PolB1)
[Methanobacterium thermoautotrophicum]
Length = 586
Score = 486 bits (1238), Expect = e-136
Identities = 256/589 (43%), Positives = 361/589 (60%), Gaps = 48/589 (8%)
Query: 1 MIIDADYITEDGKPIIRIFKKEKG---EFKVEYDRTFRPYIYALLKD-DSAIDEVKKITA 56
+++D DY+T D P+IR+F K+K E + +DR+FRPYIYA+ D D + E++++
Sbjct: 7 VLLDIDYVTVDEVPVIRLFGKDKSGGNEPIIAHDRSFRPYIYAIPTDLDECLRELEELEL 66
Query: 57 ERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPF 116
E+ +E + + LGRP EV ++ HPQDVP IR++IR+ +V DI E+DIPF
Sbjct: 67 EK---------LEVKEMRDLGRPTEVIRIEFRHPQDVPKIRDRIRDLESVRDIREHDIPF 117
Query: 117 AKRYLIDKGLTPME---------------------------------GNEELTFLAVDIE 143
+RYLIDK + PME G L L+ DIE
Sbjct: 118 YRRYLIDKSIVPMEELEFQGVEVDSAPSVTTDVRTVEVTGRVQSTGSGAHGLDILSFDIE 177
Query: 144 TLYHEG-EEFGKGPIIMISYADEEGAK-VITWKSIDLPYVEVVSSEREMIKRLVKVIREK 201
G + K I+MI A G + VI+ L +VEVV ERE+++R +++ +K
Sbjct: 178 VRNPHGMPDPEKDEIVMIGVAGNMGYESVISTAGDHLDFVEVVEDERELLERFAEIVIDK 237
Query: 202 DPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLF 261
PD+++ YN DNFDFPY+ +RA LG +L LG D S+ + R G + A IKG +H DL+
Sbjct: 238 KPDILVGYNSDNFDFPYITRRAAILGAELDLGWDGSKIRTMRRGFANATAIKGTVHVDLY 297
Query: 262 PVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFE 321
PV+RR +NL YTLE VY+ +FG+ K + + E W+ + + + +YS++D T
Sbjct: 298 PVMRRYMNLDRYTLERVYQELFGEEKIDLPGDRLWEYWDRDELRDELFRYSLDDVVATHR 357
Query: 322 LGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRL 381
+ ++ P+ +L RLVGQP++D+SR +TG EWFL+RKAY+ EL PNKP + ++ R
Sbjct: 358 IAEKILPLNLELTRLVGQPLFDISRMATGQQAEWFLVRKAYQYGELVPNKPSQSDFSSRR 417
Query: 382 RESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHR 441
GGYVKEPEKGL E IV DFRSLYPSIII+ N+SPDTL + E VAP+ G+R
Sbjct: 418 GRRAVGGYVKEPEKGLHENIVQFDFRSLYPSIIISKNISPDTLTDDEESECYVAPEYGYR 477
Query: 442 FCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYA 501
F K GF+PS++G +L ER +IK+ MK S DP+E+K+L+ +Q A+K LAN+ YG YGY+
Sbjct: 478 FRKSPRGFVPSVIGEILSERVRIKEEMKGSDDPMERKILNVQQEALKRLANTMYGVYGYS 537
Query: 502 KARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPG 550
+ RWY ECAE++TAWGR YI + E GF +Y DTDG YAT G
Sbjct: 538 RFRWYSMECAEAITAWGRDYIKKTIKTAEEFGFHTVYADTDGFYATYRG 586
>dbj|BAA93703.1| (AB032376) DNA polymerase B3 [Sulfurisphaera ohwakuensis]
Length = 781
Score = 480 bits (1222), Expect = e-134
Identities = 296/796 (37%), Positives = 436/796 (54%), Gaps = 74/796 (9%)
Query: 2 IIDADYITEDGKPIIRIFKKEK-GEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
I+D Y + KP+I I+ +K G V ++ FRPY YAL+ D IDE++K +
Sbjct: 7 ILDFSYDVVENKPVIYIWVIDKEGNRVVLLEKKFRPYFYALVDDSYNIDEIRKEILKLSK 66
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
IT ++ +KK+ G P++V K+ P V R+++ + V + E DI F RY
Sbjct: 67 PYSPITSIDVEEKKYFGSPVKVLKIETVIPAYVRVYRDEVAKIKGVKSVLEADIRFYMRY 126
Query: 121 LIDKGLTPM-----------EGN--------------------EELTFLAVDIETLYHEG 149
ID L P E N EL LA DIE G
Sbjct: 127 SIDINLKPFYWIEAEVEEIKENNFRVKKVYELKKINKLYEDKIPELKVLAFDIEVYNKYG 186
Query: 150 EEFGK-GPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIIT 208
+ P+I+I +EG K D + I+ + ++ DPD+I+
Sbjct: 187 SPNPRRDPVIIIGVWTKEGGKQFLADKYD---------DLRAIREFINFVQTYDPDIIVG 237
Query: 209 YNGDNFDFPYLLKRAEKLGIKLPLGRD-NSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRT 267
YN +NFD+PYLL+RA GI+L +GR N EP G I GR++ DL+ +
Sbjct: 238 YNINNFDWPYLLERANIRGIRLDVGRRVNGEPSQGVYGH---YSITGRLNVDLYGFAQSI 294
Query: 268 INLPTYTLEAVYEAIFGKSKEK---VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK 324
+ TLE + + + KEK V ++I + W+ K + + KY+++DAK + LG+
Sbjct: 295 QEVKVKTLENIADYLGVLPKEKRTIVEWYDIPKYWDDEKKRDILLKYNLDDAKSAYLLGE 354
Query: 325 EFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES 384
F P +L R+ G P+ +S +S G+ VEW L+R+AY+ NEL PNK +EREYE S
Sbjct: 355 VFIPFGIELTRISGLPLDQLSMASVGHRVEWLLMREAYKYNELIPNK-EEREYE-----S 408
Query: 385 YEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCK 444
YEGG V P G+ E + LDF S+YPSI+I +N+ PDTL + C+ V+P VGH+F K
Sbjct: 409 YEGGLVISPLPGIHEEVYVLDFSSMYPSIMIKYNIGPDTLVKGECENCWVSP-VGHKFRK 467
Query: 445 DFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKAR 504
+ PG ++L L++ER+++KK M+++ D +K++LD RQRA+K++AN++YGY G+ AR
Sbjct: 468 EPPGLYKNVLEKLIQERKEVKKLMEKTIDEYDKRVLDARQRALKVMANAFYGYMGWLGAR 527
Query: 505 WYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFV 564
WY KE AE+VTAWGRQ I + + +GF V+Y DTD ++ G + I E + KF
Sbjct: 528 WYSKEGAEAVTAWGRQIISDSAKIAKEKGFTVIYGDTDSIFVKGGGDINSLITEISSKFG 587
Query: 565 EYINSKLPGLLELEYEGFYARGFFV-TKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQ 623
LE++ + Y R FF KK+YA + E+GKI G E VR DW ++AK+ Q
Sbjct: 588 ----------LEIKIDKIYKRVFFTENKKRYAGLTEDGKIDIVGFEAVRGDWCDLAKQVQ 637
Query: 624 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVA 683
V+E ILK G V++A+K VK V L +Y E L+I++ I + L EY PHV A
Sbjct: 638 TNVIELILKSGKVEDAIKYVKSVIFDLRRYNFRIEDLIIWKTIDKNLDEYDVTAPHVVAA 697
Query: 684 KRLAAKGVKVKPGMVIGYIVLRGDGPISKRA---IAIEEFDPKKHKYDAEYYIENQVLPA 740
K+ A G V G+ IGY++++G G IS +A ++E K+K D EYYI+ Q++P
Sbjct: 698 KKAAKAGYLVSKGVKIGYVIVKGSGKISDKAEPYFLVKE----KNKIDVEYYIDKQIIPV 753
Query: 741 VERILRAFGYRKEDLK 756
RIL FG ++ LK
Sbjct: 754 ALRILEGFGVKESSLK 769
>pir||B56277 DNA-directed DNA polymerase (EC 2.7.7.7) II - Pyrodictium occultum
>gi|807830|dbj|BAA07580.1| (D38574) DNA polymerase
[Pyrodictium occultum]
Length = 803
Score = 464 bits (1180), Expect = e-129
Identities = 288/818 (35%), Positives = 445/818 (54%), Gaps = 83/818 (10%)
Query: 1 MIIDADYITEDGKPIIRIFKKE-KGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAE-R 58
+++D+ Y +P++ ++ G+ V D FRPY YAL+ D V++I A R
Sbjct: 8 VLLDSSYEILGKEPVVILWGITLDGKRVVLLDHRFRPYFYALIARGYE-DMVEEIAASIR 66
Query: 59 HGKIVR--ITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPF 116
+V+ I + + + K++ GRP + K+ P+ V RE +++ V D E DI F
Sbjct: 67 RLSVVKSPIIDAKPLDKRYFGRPRKAVKITTMIPESVRHYREAVKKIEGVEDSLEADIRF 126
Query: 117 AKRYLIDKGLTP------------------------MEGNEE------------LTFLAV 140
A RYLIDK L P + G+ E + +A
Sbjct: 127 AMRYLIDKRLYPFTVYRIPVEDAGRNPGFRVDRVYKVAGDPEPLADITRIDLPPMRLVAF 186
Query: 141 DIETLYHEGEEF-GKGPIIMISYADEEGA-KVITWKSIDLPYVEVVSSEREMIKRLVKVI 198
DIE G + P+I++S D EG ++I + D +R +++ V+ +
Sbjct: 187 DIEVYSRRGSPNPARDPVIIVSLRDSEGKERLIEAEGHD---------DRRVLREFVEYV 237
Query: 199 REKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD-NSEPKMQRMGDSLAVEIKGRIH 257
R DPD+I+ YN ++FD+PYL++RA +LGIKL + R +EP G V ++GR++
Sbjct: 238 RAFDPDIIVGYNSNHFDWPYLMERARRLGIKLDVTRRVGAEPTTSVYGH---VSVQGRLN 294
Query: 258 FDLFPVIRRTINLPTYTLEAVYEAI-FGKSKEKVYAH--EIAEAWETGKGLERVAKYSME 314
DL+ + TLE V E + K E+V I E W+ K + + +Y+++
Sbjct: 295 VDLYDYAEEMPEIKMKTLEEVAEYLGVMKKSERVIIEWWRIPEYWDDEKKRQLLERYALD 354
Query: 315 DAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDE 374
D + T+ L ++ P QL+ + G P+ V G +EW+L+R AY+ NEL PN+ +
Sbjct: 355 DVRATYGLAEKMLPFAIQLSTVTGVPLDQVGAMGVGFRLEWYLMRAAYDMNELVPNRVER 414
Query: 375 REYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTL--NRENCKEY 432
R ESY+G V +P KG+ E +V LDF S+YPSI+I +NV PDT+ + C +Y
Sbjct: 415 RG------ESYKGAVVLKPLKGVHENVVVLDFSSMYPSIMIKYNVGPDTIVDDPSECPKY 468
Query: 433 D---VAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKE-SKDPVEKKLLDYRQRAIK 488
VAP+VGHRF + PGF ++L NLL+ R+++K++MKE D E +L D RQ+A+K
Sbjct: 469 GGCYVAPEVGHRFRRSPPGFFKTVLENLLKLRRQVKEKMKEFPPDSPEYRLYDERQKALK 528
Query: 489 ILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATI 548
+LAN+ YGY G++ ARWYCK CAE+VTAWGR I G KV+Y DTD L+
Sbjct: 529 VLANASYGYMGWSHARWYCKRCAEAVTAWGRNLILTAIEYARKLGLKVIYGDTDSLFVVY 588
Query: 549 PGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFV-TKKKYALIDEEGKIVTRG 607
KEK K +E++ +L E++ + Y + FF KK+Y + E+G+I G
Sbjct: 589 D-------KEKVEKLIEFVEKELG--FEIKIDKIYKKVFFTEAKKRYVGLLEDGRIDIVG 639
Query: 608 LEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQIT 667
E VR DW E+AKE Q K E +L GNVD+A+ ++EV ++L + ++P KL+I++ ++
Sbjct: 640 FEAVRGDWCELAKEVQEKAAEIVLNTGNVDKAISYIREVIKQLREGKVPITKLIIWKTLS 699
Query: 668 RPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKY 727
+ + EY+ PHV A+R+ G +V PG +GY++++G G +S RA DP
Sbjct: 700 KRIEEYEHDAPHVMAARRMKEAGYEVSPGDKVGYVIVKGSGSVSSRAYPYFMVDPS--TI 757
Query: 728 DAEYYIENQVLPAVERILRAFGYRKEDLKYQKTKQVGL 765
D YYI++Q++PA RIL FG ++ LK T Q L
Sbjct: 758 DVNYYIDHQIVPAALRILSYFGVTEKQLKAAATVQRSL 795
>sp|O93746|DPO2_AERPE DNA POLYMERASE II >gi|7434801|pir||E72515 probable DNA-directed DNA
polymerase APE2098 - Aeropyrum pernix (strain K1)
>gi|5105797|dbj|BAA81109.1| (AP000063) 784aa long
hypothetical DNA-directed DNA polymerase [Aeropyrum
pernix]
Length = 784
Score = 440 bits (1119), Expect = e-122
Identities = 280/770 (36%), Positives = 410/770 (52%), Gaps = 75/770 (9%)
Query: 34 FRPYIYALLKDDSAIDEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDV 93
FRPY Y L +D++ + I VE+V+++F+GR +E K+ P V
Sbjct: 27 FRPYFYVLPDGSVGLDQLAAMIRRLSRPSSPILSVERVRRRFIGREVEALKVTTLVPASV 86
Query: 94 PAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTPM------------------------ 129
RE +R V D+ E DIPFA R++ID L PM
Sbjct: 87 REYREAVRRLGGVRDVLEADIPFALRFIIDFNLYPMRWYVAEVREVAVPHGYSVDRAYTL 146
Query: 130 -------------EGNEELTFLAVDIETLYH-EGEEFGKGPIIMISYADEEGAKVITWKS 175
+ + L +A DIE + K P+IMI + G ++ ++
Sbjct: 147 SGDIREDETRIQEDPLKGLRVMAFDIEVYSKMRTPDPKKDPVIMIGL-QQAGGEIEILEA 205
Query: 176 IDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD 235
D S++++I V+ ++ DPDVI+ YN + FD+PYL++RA LG+KL +GR
Sbjct: 206 ED-------RSDKKVIAGFVERVKSIDPDVIVGYNQNRFDWPYLVERARVLGVKLAVGRR 258
Query: 236 NSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAI-FGKSKEKVYAH- 293
+ EP+ G + GR++ DL + TLE V + + K E+V
Sbjct: 259 SVEPQPGLYGH---YSVSGRLNVDLLDFAEELHEVKVKTLEEVADYLGVVKIGERVTLEW 315
Query: 294 -EIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNL 352
+I E W+ E + KY +D + T L ++F P A+L+++ G P+ V +S G
Sbjct: 316 WQIGEYWDDPSKREILRKYLRDDVRSTMGLAEKFLPFGAELSQVSGLPLDQVMAASVGFR 375
Query: 353 VEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPS 412
+EW L+R+A + EL PN+ + E Y G V P+ G+ E I LDF S+YP+
Sbjct: 376 LEWRLIREAAKLGELVPNRVERSEGR------YAGAIVLRPKPGVHEDIAVLDFASMYPN 429
Query: 413 IIITHNVSPDTLNR--ENCKEYDV--APQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRM 468
I++ +NV PDTL R E E +V AP+VGH+F K PGF +L L R++I+ M
Sbjct: 430 IMVKYNVGPDTLVRPGEEYGEEEVYTAPEVGHKFRKSPPGFFKKILERFLSWRRQIRSEM 489
Query: 469 KESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRR 527
K+ D E KLLD RQ+AIK+LAN+ YGY G+ ARWYC+ECAE+VTAWGR I R
Sbjct: 490 KKHPPDSPEYKLLDERQKAIKLLANASYGYMGWPHARWYCRECAEAVTAWGRSIIRTAIR 549
Query: 528 ELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGF 587
+ G +V+Y DTD L+ + EK + + ++ +L +++ + Y R F
Sbjct: 550 KAGELGLEVIYGDTDSLFV-------KNDPEKVERLIRFVEEELG--FDIKVDKVYRRVF 600
Query: 588 FV-TKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEV 646
F KK+Y + +GKI G E VR DWSE+AKETQ KV E +LK G+VDEAV V+ +
Sbjct: 601 FTEAKKRYVGLTVDGKIDVVGFEAVRGDWSELAKETQFKVAEIVLKTGSVDEAVDYVRNI 660
Query: 647 TEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRG 706
EKL + ++ KLVI++ +TRP S Y+A PHV A + G+KV+PG IGY+V +G
Sbjct: 661 IEKLRRGQVDMRKLVIWKTLTRPPSMYEARQPHVTAALLMERAGIKVEPGAKIGYVVTKG 720
Query: 707 DGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLK 756
GP+ RA F K + D EYY++ QV+PA RIL+ FG ++ LK
Sbjct: 721 SGPLYTRAKPY--FMASKEEVDVEYYVDKQVVPAALRILQYFGVTEKRLK 768
>gb|AAF27815.1|AF195019_1 (AF195019) family B DNA polymerase [Pyrobaculum islandicum]
Length = 785
Score = 431 bits (1096), Expect = e-119
Identities = 274/799 (34%), Positives = 430/799 (53%), Gaps = 79/799 (9%)
Query: 3 IDADYITEDGKPIIRIFK-KEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHGK 61
+D Y P IRIF GE V DR+F+PY Y D A+ E + +
Sbjct: 8 LDITYAVVGSVPEIRIFGILSSGERVVLIDRSFKPYFYV----DCAVCEPAALKTAL-SR 62
Query: 62 IVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYL 121
+ I +V+ V+++FLGR + K+ + P+DV +RE P V ++E DI F RY+
Sbjct: 63 VAPIDDVQIVERRFLGRSKKFLKVIAKIPEDVRKLREAAMSIPRVSGVYEADIRFYMRYM 122
Query: 122 IDKGLTPMEGN-----------------------------EELTFLAVDIETLYHEGEEF 152
ID G+ P N L +A DIE G
Sbjct: 123 IDMGVVPCSWNVAEVEEGGRLGGIPTYVVSQWYGIDEGFPPSLKVMAFDIEVYNERGSPD 182
Query: 153 G-KGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNG 211
+ P++M++ +G + + S +R +++ V IR DPDVI+ YN
Sbjct: 183 PIRDPVVMLAIKTNDGHEEVFEAS--------GKDDRGVVRAFVDFIRSYDPDVIVGYNS 234
Query: 212 DNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLP 271
+ FD+PYL++RA+ +G+ L + R ++ P+ G I GR + DL+ ++ +
Sbjct: 235 NGFDWPYLVERAKAVGVPLKVDRLSNPPQQSVYGHW---SIVGRANVDLYNIVEEFPEIK 291
Query: 272 TYTLEAVYEAIFG--KSKEKVY--AHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFF 327
TL+ V E FG K +E+V H+I E W+ + +Y ++D + T L +
Sbjct: 292 LKTLDRVAE-YFGVMKREERVLIPGHKIYEYWKDPNKRPLLKRYVLDDVRSTLGLADKLL 350
Query: 328 PMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEG 387
P QL+ + G P+ V+ +S GN VEW LLR AY E+APN+ +EREYE Y+G
Sbjct: 351 PFLIQLSSVSGLPLDQVAAASVGNRVEWMLLRYAYRLGEVAPNR-EEREYE-----PYKG 404
Query: 388 GYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTL----NRENCKEYDVAPQVGHRFC 443
V EP+ G++E ++ LDF S+YP+I++ +N+SPDT + + +VAP+VGHRF
Sbjct: 405 AIVLEPKPGMYEDVLVLDFSSMYPNIMMKYNLSPDTYLEPGEPDPPEGVNVAPEVGHRFR 464
Query: 444 KDFPGFIPSLLGNLLEERQKIKKRMKE-SKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
+ PGF+P +L +L+E R+ +++ K+ D E K+LD RQRA+K++AN+ YGY G+
Sbjct: 465 RSPPGFVPQVLKSLVELRKAVREEAKKYPPDSPEFKILDERQRALKVMANAIYGYLGWVG 524
Query: 503 ARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALK 562
ARWY +E AESVTA+ R + V + G V+Y DTD L+ KH ++ K
Sbjct: 525 ARWYKREVAESVTAFARAILKDVIEQARRLGIVVVYGDTDSLFV----KKHGDVD----K 576
Query: 563 FVEYINSKLPGLLELEYEGFYARGFFV-TKKKYALIDEEGKIVTRGLEIVRRDWSEIAKE 621
++Y+ K ++++ + YA+ F KK+YA + +G+I G E+VR DWSE+AK+
Sbjct: 577 LIKYVEEKYG--IDIKVDKDYAKVLFTEAKKRYAGLLRDGRIDIVGFEVVRGDWSELAKD 634
Query: 622 TQAKVLEAILKHGNVDEA----VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG 677
Q +V+E ILK ++ EA +K ++E+ E+L Y+ + L+I++ + + L EYKA
Sbjct: 635 VQLRVIEIILKSRDIVEARHGVIKYIREIIERLKNYKFNIDDLIIWKTLDKELDEYKAYP 694
Query: 678 PHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
PHV A+ L G +V G IGY++++G +S+RA+ D K K D +YYIE Q+
Sbjct: 695 PHVHAAQILKRHGYRVGKGTTIGYVIVKGGEKVSERALPYILLDDIK-KIDIDYYIERQI 753
Query: 738 LPAVERILRAFGYRKEDLK 756
+PA RI G ++ DLK
Sbjct: 754 IPAALRIAEVIGVKESDLK 772
>dbj|BAA75663.1| (AB017501) DNA polymerase II [Aeropyrum pernix]
Length = 772
Score = 427 bits (1087), Expect = e-118
Identities = 270/751 (35%), Positives = 395/751 (51%), Gaps = 82/751 (10%)
Query: 34 FRPYIYALLKDDSAIDEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDV 93
FRPY Y L +D++ + I VE+V+++F+GR +E K+ P V
Sbjct: 27 FRPYFYVLPDGSVGLDQLAAMIRRLSRPSSPILSVERVRRRFIGREVEALKVTTLVPASV 86
Query: 94 PAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTPM------------------------ 129
RE +R V D+ + DIPFA R++ID L PM
Sbjct: 87 REYREAVRRLGGVRDVLKADIPFALRFIIDFNLYPMRWYVAEVREVAVPHGYSVDRAYTL 146
Query: 130 -------------EGNEELTFLAVDIETLYH-EGEEFGKGPIIMISYADEEGAKVITWKS 175
+ + L +A DIE + K P+IMI + G ++ ++
Sbjct: 147 SGDIREDETRIQEDPLKGLRVMAFDIEVYSKMRTPDPKKDPVIMIGL-QQAGGEIEILEA 205
Query: 176 IDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD 235
D S++++I V+ ++ DPDVI+ YN + FD+PYL++RA LG+KL +GR
Sbjct: 206 ED-------RSDKKVIAGFVERVKSIDPDVIVGYNQNRFDWPYLVERARVLGVKLAVGRR 258
Query: 236 NSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEI 295
+ EP+ G + GR++ DL + TLE V + Y +
Sbjct: 259 SVEPQPGLYGH---YSVSGRLNVDLLDFAEELHEVKVKTLEEVAD----------YLGVV 305
Query: 296 AEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEW 355
E W+ E + KY +D + T L ++F P AQL+++ G P+ V +S G +EW
Sbjct: 306 REYWDDPSKREILRKYLRDDVRSTMGLAEKFLPFGAQLSQVSGLPLDQVMAASVGFRLEW 365
Query: 356 FLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIII 415
L+R+A + EL PN+ + E Y G V P+ G+ E I LDF S+YP+I++
Sbjct: 366 RLIREAAKLGELVPNRVERSEGR------YAGAIVLRPKPGVHEDIAVLDFASMYPNIMV 419
Query: 416 THNVSPDTLNR--ENCKEYDV--APQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKES 471
+NV PDTL R E E +V AP+VGH+F K PGF +L L R++I+ MK+
Sbjct: 420 KYNVGPDTLVRPGEEYGEEEVYTAPEVGHKFRKSPPGFFKKILERFLSWRRQIRSEMKKH 479
Query: 472 K-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELE 530
D E KLLD RQ+AIK+LAN+ YGY G+ ARWYC+ECAE+VTAWGR I R+
Sbjct: 480 PPDSPEYKLLDERQKAIKLLANASYGYMGWPHARWYCRECAEAVTAWGRSIIRTAIRKAG 539
Query: 531 SRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFV- 589
G +V+Y DTD L+ + EK + + ++ +L +++ + Y R FF
Sbjct: 540 ELGLEVIYGDTDSLFV-------KNDPEKVERLIRFVEEELG--FDIKVDKVYRRVFFTE 590
Query: 590 TKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEK 649
KK+Y + +GKI G E VR DWSE+AKETQ KV E +LK G+VDEAV V+ + EK
Sbjct: 591 AKKRYVGLTVDGKIDVVGFEAVRGDWSELAKETQFKVAEIVLKTGSVDEAVDYVRNIIEK 650
Query: 650 LSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGP 709
L + ++ KLVI++ +TRP S Y+A PHV A + G+KV+PG IGY+V +G GP
Sbjct: 651 LRRGQVDMRKLVIWKTLTRPPSMYEARQPHVTAALLMERAGIKVEPGAKIGYVVTKGSGP 710
Query: 710 ISKRAIAIEEFDPKKHKYDAEYYIENQVLPA 740
+ RA F K + D EYY++ QV+PA
Sbjct: 711 LYTRAKPY--FMASKEEVDVEYYVDKQVVPA 739
>emb|CAC12848.1| (AJ250334) DNA polymerase [Thermococcus chitonophagus]
Length = 195
Score = 353 bits (897), Expect = 3e-96
Identities = 172/195 (88%), Positives = 181/195 (92%)
Query: 122 IDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYV 181
IDKGL PMEG+EEL LA DIETLYHEGEEF KGPIIMISYADEEG KVITWK +DLPYV
Sbjct: 1 IDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEGTKVITWKKVDLPYV 60
Query: 182 EVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKM 241
EVVSSEREMIKR +KVIREKDPDVIITYNGD+FD PYL+KRAE+LGIKLPLGRD SEPKM
Sbjct: 61 EVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAERLGIKLPLGRDGSEPKM 120
Query: 242 QRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWET 301
QR+GD AVEIKGRIHFDL+ VIRRTINLPTYTLEAVYEAIFGK KEKVYAHEIAEAWET
Sbjct: 121 QRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWET 180
Query: 302 GKGLERVAKYSMEDA 316
GKGLERVA+YSMEDA
Sbjct: 181 GKGLERVARYSMEDA 195
>sp|Q58295|DPOL_METJA DNA POLYMERASE >gi|2826345|gb|AAB98889.1| (U67532) DNA polymerase
B1 [Methanococcus jannaschii]
Length = 1634
Score = 311 bits (788), Expect = 2e-83
Identities = 172/423 (40%), Positives = 261/423 (61%), Gaps = 27/423 (6%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSA----IDEVKKITAE 57
+ID Y T + K +I ++ + DR F+PY Y L + I+++K+
Sbjct: 13 LIDNTYKTIEDKAVIYLYLINS----ILKDRDFKPYFYVELHKEKVENEDIEKIKEFLL- 67
Query: 58 RHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFA 117
++ + + +E V+K L + EV K+ HPQ VP +R KI+E V +I+E+DIPFA
Sbjct: 68 KNDLLKFVENIEVVKKIILRKEKEVIKIIATHPQKVPKLR-KIKECEIVKEIYEHDIPFA 126
Query: 118 KRYLIDKGLTPM-----EGNE-------ELTFLAVDIETLYHEGEEFG-KGPIIMISYAD 164
KRYLID + PM E + +L +A D+E + E + PI+M S+ D
Sbjct: 127 KRYLIDNEIIPMTYWDFENKKPVSIEIPKLKSVAFDMEVYNRDTEPNPERDPILMASFWD 186
Query: 165 EEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE 224
E G KVIT+K + P +EVV +E+E+IK++++ ++E D VI TYNGDNFDFPYL RA+
Sbjct: 187 ENGGKVITYKEFNHPNIEVVKNEKELIKKIIETLKEYD--VIYTYNGDNFDFPYLKARAK 244
Query: 225 KLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFG 284
GI + LG+D E K++R G I GR+H DL+P+ RR + L YTLE V +FG
Sbjct: 245 IYGIDINLGKDGEELKIKRGGMEYRSYIPGRVHIDLYPISRRLLKLTKYTLEDVVYNLFG 304
Query: 285 KSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDV 344
K K+ +I + W + + +YS++DAK T+++GK FFP+E +R+V Q +++
Sbjct: 305 IEKLKIPHTKIVDYWANND--KTLIEYSLQDAKYTYKIGKYFFPLEVMFSRIVNQTPFEI 362
Query: 345 SRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSL 404
+R S+G +VE+ L+++A++ N + PNKPDE EY RR+ +YEGGYVKEPEKG++E I+S+
Sbjct: 363 TRMSSGQMVEYLLMKRAFKENMIVPNKPDEEEYRRRVLTTYEGGYVKEPEKGMFEDIISM 422
Query: 405 DFR 407
DFR
Sbjct: 423 DFR 425
Score = 273 bits (692), Expect = 4e-72
Identities = 139/266 (52%), Positives = 186/266 (69%), Gaps = 3/266 (1%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGA 551
NS YGY + +AR+Y +ECAE VT GR+YI +E E GFKVLYIDTDG YA
Sbjct: 1358 NSVYGYLAFPRARFYSRECAEIVTYLGRKYILETVKEAEKFGFKVLYIDTDGFYAIWKEK 1417
Query: 552 -KHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI 610
EE+ +KA++FVEYINSKLPG +ELE+EG++ RG FVTKK+YALIDE G++ +GLE
Sbjct: 1418 ISKEELIKKAMEFVEYINSKLPGTMELEFEGYFKRGIFVTKKRYALIDENGRVTVKGLEF 1477
Query: 611 VRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL 670
VRRDWS IAK TQ +VLEA+L G++++A KI+++V + L + +I E L+IY Q+T+
Sbjct: 1478 VRRDWSNIAKITQRRVLEALLVEGSIEKAKKIIQDVIKDLREKKIKKEDLIIYTQLTKDP 1537
Query: 671 SEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAE 730
EYK PHV +AK+L +G ++K G +IGYI+++G IS+RA EE D D
Sbjct: 1538 KEYKTTAPHVEIAKKLMREGKRIKVGDIIGYIIVKGTKSISERAKLPEEVD--IDDIDVN 1595
Query: 731 YYIENQVLPAVERILRAFGYRKEDLK 756
YYI+NQ+LP V RI+ A G K +LK
Sbjct: 1596 YYIDNQILPPVLRIMEAVGVSKNELK 1621
Score = 87.4 bits (213), Expect = 5e-16
Identities = 50/95 (52%), Positives = 64/95 (66%), Gaps = 7/95 (7%)
Query: 404 LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQV-GHRFCKDFPGFIPSLLGNLLEERQ 462
L SLYPSIII++N+SPDTL+ E CK DV+ ++ GH FCK G IP L NL+E R
Sbjct: 791 LTHNSLYPSIIISYNISPDTLDCECCK--DVSEKILGHWFCKKKEGLIPKTLRNLIERRI 848
Query: 463 KIKKRMKESKD----PVEKKLLDYRQRAIKILANS 493
IK+RMK+ + E LLDY Q+++KILANS
Sbjct: 849 NIKRRMKKMAEIGEINEEYNLLDYEQKSLKILANS 883
>pir||E64410 DNA-directed DNA polymerase (EC 2.7.7.7) family B, intein
containing precursor - Methanococcus jannaschii
Length = 1634
Score = 310 bits (787), Expect = 3e-83
Identities = 172/423 (40%), Positives = 261/423 (61%), Gaps = 27/423 (6%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSA----IDEVKKITAE 57
+ID Y T + K +I ++ + DR F+PY Y L + I+++K+
Sbjct: 13 LIDNTYKTIEDKAVIYLYLINS----ILKDRDFKPYFYVELHKEKVENEDIEKIKEFLL- 67
Query: 58 RHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFA 117
++ + + +E V+K L + EV K+ HPQ VP +R KI+E V +I+E+DIPFA
Sbjct: 68 KNDLLKFVENIEVVKKIILRKEKEVIKIIATHPQKVPKLR-KIKECEIVKEIYEHDIPFA 126
Query: 118 KRYLIDKGLTPM-----EGNE-------ELTFLAVDIETLYHEGEEFG-KGPIIMISYAD 164
KRYLID + PM E + +L +A D+E + E + PI+M S+ D
Sbjct: 127 KRYLIDNEIIPMTYWDFENKKPVSIEIPKLKSVAFDMEVYNRDTEPNPERDPILMASFWD 186
Query: 165 EEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE 224
E G KVIT+K + P +EVV +E+E+IK++++ ++E D VI TYNGDNFDFPYL RA+
Sbjct: 187 ENGGKVITYKEFNHPNIEVVKNEKELIKKIIETLKEYD--VIYTYNGDNFDFPYLKARAK 244
Query: 225 KLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFG 284
GI + LG+D E K++R G I GR+H DL+P+ RR + L YTLE V +FG
Sbjct: 245 IYGIDINLGKDGEELKIKRGGMEYRSYIPGRVHIDLYPISRRLLKLTKYTLEDVVYNLFG 304
Query: 285 KSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDV 344
K K+ +I + W + + +YS++DAK T+++GK FFP+E +R+V Q +++
Sbjct: 305 IEKLKIPHTKIVDYWANND--KTLIEYSLQDAKYTYKIGKYFFPLEVMFSRIVNQTPFEI 362
Query: 345 SRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSL 404
+R S+G +VE+ L+++A++ N + PNKPDE EY RR+ +YEGGYVKEPEKG++E I+S+
Sbjct: 363 TRMSSGQMVEYLLMKRAFKXNMIVPNKPDEEEYRRRVLTTYEGGYVKEPEKGMFEDIISM 422
Query: 405 DFR 407
DFR
Sbjct: 423 DFR 425
Score = 273 bits (692), Expect = 4e-72
Identities = 139/266 (52%), Positives = 186/266 (69%), Gaps = 3/266 (1%)
Query: 492 NSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGA 551
NS YGY + +AR+Y +ECAE VT GR+YI +E E GFKVLYIDTDG YA
Sbjct: 1358 NSVYGYLAFPRARFYSRECAEIVTYLGRKYILETVKEAEKFGFKVLYIDTDGFYAIWKEK 1417
Query: 552 -KHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEI 610
EE+ +KA++FVEYINSKLPG +ELE+EG++ RG FVTKK+YALIDE G++ +GLE
Sbjct: 1418 ISKEELIKKAMEFVEYINSKLPGTMELEFEGYFKRGIFVTKKRYALIDENGRVTVKGLEF 1477
Query: 611 VRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPL 670
VRRDWS IAK TQ +VLEA+L G++++A KI+++V + L + +I E L+IY Q+T+
Sbjct: 1478 VRRDWSNIAKITQRRVLEALLVEGSIEKAKKIIQDVIKDLREKKIKKEDLIIYTQLTKDP 1537
Query: 671 SEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAE 730
EYK PHV +AK+L +G ++K G +IGYI+++G IS+RA EE D D
Sbjct: 1538 KEYKTTAPHVEIAKKLMREGKRIKVGDIIGYIIVKGTKSISERAKLPEEVD--IDDIDVN 1595
Query: 731 YYIENQVLPAVERILRAFGYRKEDLK 756
YYI+NQ+LP V RI+ A G K +LK
Sbjct: 1596 YYIDNQILPPVLRIMEAVGVSKNELK 1621
Score = 87.4 bits (213), Expect = 5e-16
Identities = 50/95 (52%), Positives = 64/95 (66%), Gaps = 7/95 (7%)
Query: 404 LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQV-GHRFCKDFPGFIPSLLGNLLEERQ 462
L SLYPSIII++N+SPDTL+ E CK DV+ ++ GH FCK G IP L NL+E R
Sbjct: 791 LTHNSLYPSIIISYNISPDTLDCECCK--DVSEKILGHWFCKKKEGLIPKTLRNLIERRI 848
Query: 463 KIKKRMKESKD----PVEKKLLDYRQRAIKILANS 493
IK+RMK+ + E LLDY Q+++KILANS
Sbjct: 849 NIKRRMKKMAEIGEINEEYNLLDYEQKSLKILANS 883
>gb|AAK40441.1| DNA polymerase III (DNA polymerase B3) (pfu polymerase). (dpo3)
[Sulfolobus solfataricus]
Length = 764
Score = 251 bits (635), Expect = 2e-65
Identities = 204/795 (25%), Positives = 362/795 (44%), Gaps = 94/795 (11%)
Query: 2 IIDADYITEDGKPIIRIFK-KEKGEFKVEYDRTFRPYIYALLK--DDSAIDEVKKITAER 58
I+D Y + P++ I+ ++G V D FRPY Y + + ++ I+ +KK
Sbjct: 7 ILDFSYEIKGNTPLVYIWSVDDEGNSSVVIDNNFRPYFYIIYEGNENEIIENIKKNC--- 63
Query: 59 HGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDI---- 114
++ KV++K+LG ++ + P + REKI E + IF+ DI
Sbjct: 64 -----EALQITKVKRKYLGNIVDALLIQTSTPTQIKKCREKISELNNIKGIFDADIRYTM 118
Query: 115 ---------PFA-----------------KRYLIDKGLTPMEGN-EELTFLAVDIETLYH 147
PF K Y++DK L+ EGN EL + VD +
Sbjct: 119 RYSLDFDLRPFTWFRAEVNEVKFDGFRTKKAYILDKILSHYEGNMPELRTIGVDFQIYSK 178
Query: 148 EGE-EFGKGPIIMISYADEEGAKVITW-KSIDLPYVEVVSSEREMIKRLVKVIREKDPDV 205
G K PI+++S +EG + + ID + ++I+R V I DPD+
Sbjct: 179 YGSLNPRKDPIVVMSLWSKEGPMQFSLDEGID---------DLKIIRRFVDYILNYDPDI 229
Query: 206 IITYNGDNFDFPYLLKRAEKLGIKLPLGRD-NSEPKMQRMGDSLAVEIKGRIHFDLFPVI 264
I Y+ D + Y+ +RA LG+K+ +GR SE + G I GR++ DL ++
Sbjct: 230 IFVYDSDLLPWKYITERASSLGVKIDIGRKIGSEVSVGTYGH---YSISGRLNVDLTGLL 286
Query: 265 RRTINLPTYTLEAVYEAI-FGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELG 323
+L L V + S+ +EI+ W+ K + +YS+E+A+ + LG
Sbjct: 287 VNERSLGHVDLIDVSNYLGISPSRYSFKWYEISRYWDNEKNRRIIREYSIENARSIYLLG 346
Query: 324 KEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRE 383
++L ++VG P+ +S +S GN +E L+R A + EL P + D ++++
Sbjct: 347 NYLLSTYSELVKIVGLPLDKLSVASWGNRIETSLIRTATKSGELIPIRMDNPNRPSKIKK 406
Query: 384 SYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFC 443
+ + +P+ G++ + LD S+Y +I N++PDTL +E C + +P ++F
Sbjct: 407 NI----IIQPKVGIYTDVYVLDISSVYSLVIRKFNIAPDTLVKEQCDDCYSSPISNYKFK 462
Query: 444 KDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKA 503
++ G + L L R K ++ E L +S+ Y + A
Sbjct: 463 REPSGLYKTFLDELSNVRDSNKIKVIEE------------------LISSFNDYVHWVNA 504
Query: 504 RWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKF 563
RWY +E A + + + I + ++S G V+ + L + G +++ E K
Sbjct: 505 RWYSREIASAFDEFSNEIIRFIIDLIKSSGLDVIL--ANDLLIFVTGGSRDKVNELITKI 562
Query: 564 VEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQ 623
N L+++ + FY + +YA + E KI + E+A+ +
Sbjct: 563 NSLYN------LDVKVKIFYKSLLVLDNNRYAGLSEGDKIDIARKGEEDMNLCELARNIK 616
Query: 624 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVA 683
K++E IL +V +A+K+VK KL + E E+L+ + +I R L+EY P V A
Sbjct: 617 RKIIEEILISKDVKKAIKLVKSTVIKLRRGEFDNEELITWAKIERDLNEYNNQLPFVTAA 676
Query: 684 KRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF--DPKKHKYDAEYYIENQVLPAV 741
++ G + IGY++++G GP++ RA E F +K++ D EYY++ Q+
Sbjct: 677 RKAIQSGYLISKDSKIGYVIVKGLGPLNDRA---EPFFLVKEKNRIDIEYYVD-QIFRET 732
Query: 742 ERILRAFGYRKEDLK 756
++L+ G +E LK
Sbjct: 733 LKLLKPLGVNEESLK 747
>sp|P95979|DPO3_SULSO DNA POLYMERASE III (DNA POLYMERASE B3) >gi|7434810|pir||S75407
probable DNA-directed DNA polymerase (EC 2.7.7.7) -
Sulfolobus solfataricus >gi|1707813|emb|CAA69570.1|
(Y08257) DNA polymerase delta large chain [Sulfolobus
solfataricus]
Length = 764
Score = 251 bits (635), Expect = 2e-65
Identities = 204/795 (25%), Positives = 362/795 (44%), Gaps = 94/795 (11%)
Query: 2 IIDADYITEDGKPIIRIFK-KEKGEFKVEYDRTFRPYIYALLK--DDSAIDEVKKITAER 58
I+D Y + P++ I+ ++G V D FRPY Y + + ++ I+ +KK
Sbjct: 7 ILDFSYEIKGNTPLVYIWSVDDEGNSSVVIDNNFRPYFYIIYEGNENEIIENIKKNC--- 63
Query: 59 HGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDI---- 114
++ KV++K+LG ++ + P + REKI E + IF+ DI
Sbjct: 64 -----EALQITKVKRKYLGNIVDALLIQTSTPTQIKKCREKISELNNIKGIFDADIRYTM 118
Query: 115 ---------PFA-----------------KRYLIDKGLTPMEGN-EELTFLAVDIETLYH 147
PF K Y++DK L+ EGN EL + VD +
Sbjct: 119 RYSLDFDLRPFTWFRAEVNEVKFDGFRTKKAYILDKILSHYEGNMPELRTIGVDFQIYSK 178
Query: 148 EGE-EFGKGPIIMISYADEEGAKVITW-KSIDLPYVEVVSSEREMIKRLVKVIREKDPDV 205
G K PI+++S +EG + + ID + ++I+R V I DPD+
Sbjct: 179 YGSLNPRKDPIVVMSLWSKEGPMQFSLDEGID---------DLKIIRRFVDYILNYDPDI 229
Query: 206 IITYNGDNFDFPYLLKRAEKLGIKLPLGRD-NSEPKMQRMGDSLAVEIKGRIHFDLFPVI 264
I Y+ D + Y+ +RA LG+K+ +GR SE + G I GR++ DL ++
Sbjct: 230 IFVYDSDLLPWKYITERASSLGVKIDIGRKIGSEVSVGTYGH---YSISGRLNVDLTGLL 286
Query: 265 RRTINLPTYTLEAVYEAI-FGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELG 323
+L L V + S+ +EI+ W+ K + +YS+E+A+ + LG
Sbjct: 287 VNERSLGHVDLIDVSNYLGISPSRYSFKWYEISRYWDNEKNRRIIREYSIENARSIYLLG 346
Query: 324 KEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRE 383
++L ++VG P+ +S +S GN +E L+R A + EL P + D ++++
Sbjct: 347 NYLLSTYSELVKIVGLPLDKLSVASWGNRIETSLIRTATKSGELIPIRMDNPNRPSKIKK 406
Query: 384 SYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFC 443
+ + +P+ G++ + LD S+Y +I N++PDTL +E C + +P ++F
Sbjct: 407 NI----IIQPKVGIYTDVYVLDISSVYSLVIRKFNIAPDTLVKEQCDDCYSSPISNYKFK 462
Query: 444 KDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKA 503
++ G + L L R K ++ E L +S+ Y + A
Sbjct: 463 REPSGLYKTFLDELSNVRDSNKIKVIEE------------------LISSFNDYVHWVNA 504
Query: 504 RWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKF 563
RWY +E A + + + I + ++S G V+ + L + G +++ E K
Sbjct: 505 RWYSREIASAFDEFSNEIIRFIIDLIKSSGLDVIL--ANDLLIFVTGGSRDKVNELITKI 562
Query: 564 VEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQ 623
N L+++ + FY + +YA + E KI + E+A+ +
Sbjct: 563 NSLYN------LDVKVKIFYKSLLVLDNNRYAGLSEGDKIDIARKGEEDMNLCELARNIK 616
Query: 624 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVA 683
K++E IL +V +A+K+VK KL + E E+L+ + +I R L+EY P V A
Sbjct: 617 RKIIEEILISKDVKKAIKLVKSTVIKLRRGEFDNEELITWAKIERDLNEYNNQLPFVTAA 676
Query: 684 KRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEF--DPKKHKYDAEYYIENQVLPAV 741
++ G + IGY++++G GP++ RA E F +K++ D EYY++ Q+
Sbjct: 677 RKAIQSGYLISKDSKIGYVIVKGLGPLNDRA---EPFFLVKEKNRIDIEYYVD-QIFRET 732
Query: 742 ERILRAFGYRKEDLK 756
++L+ G +E LK
Sbjct: 733 LKLLKPLGVNEESLK 747
>sp|O05706|DPO3_SULSH DNA POLYMERASE III (DNA POLYMERASE B3) >gi|2052351|gb|AAB53089.1|
(U92874) DNA polymerase [Sulfolobus shibatae]
Length = 763
Score = 247 bits (625), Expect = 3e-64
Identities = 211/791 (26%), Positives = 365/791 (45%), Gaps = 87/791 (10%)
Query: 2 IIDADYITEDGKPIIRIFK-KEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
I+D Y +D P+I I+ ++G V +R F+PY Y + + + DE+ E
Sbjct: 7 ILDFSYEIKDNIPLIYIWSIDDEGNSCVVVERNFKPYFYVVYEGNG--DEI----IENIR 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
K + + KV++K+LG ++ + P + REKI + IF+ DI F RY
Sbjct: 61 KNCEVLLITKVKRKYLGNVVDALLVQTFTPTQIKRCREKISRINGIKSIFDADIRFTMRY 120
Query: 121 LIDKGLTP------------MEGNEELTFLAVDIETLYHEGE---------------EFG 153
ID L P +EG +D ++EG+ ++G
Sbjct: 121 SIDFDLRPFTWFKAEVSEVKLEGFRAKKVYILDKILSHYEGKIPELRAIGIDFQIYSKYG 180
Query: 154 -----KGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIIT 208
K PI+++S +EG+ + ++ + ++I++ V I DPD+I
Sbjct: 181 SLNPRKDPIVVLSLWSKEGSMQFS--------LDESMDDLKIIRKFVDYILNYDPDIIYV 232
Query: 209 YNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVI---R 265
++ D F + Y+ +RA LG+K+ +GR Q G I GR++ DL ++ R
Sbjct: 233 FDVDVFHWKYITERANSLGVKIDIGRKIGSEVSQ--GTYGHYSISGRLNVDLVGLLMNER 290
Query: 266 RTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKE 325
T ++ + A Y I K ++ + +EI+ W+ K + V +YS+E+AK + LG
Sbjct: 291 LTGHIDLIEV-ANYLGISPK-RDSLNWYEISRYWDDEKNRDLVKQYSLENAKSIYLLGNF 348
Query: 326 FFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESY 385
++L +++G P+ +S +S GN +E L+R A + EL P + D +++++
Sbjct: 349 LLSPYSELVKIIGLPLDKLSVASWGNRIEASLIRTAAKSEELIPIRMDNPNRSSKIKKT- 407
Query: 386 EGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKD 445
V EP+ G++ + LD S+Y S+I N+SPDTL + C + V+ ++F K+
Sbjct: 408 ----VIEPKIGIYSDVYVLDISSVYLSVIRKFNISPDTLVKGQCDDCYVSTISNYKFKKE 463
Query: 446 FPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARW 505
G L LEE I+ K + I+ L +S+Y Y + +RW
Sbjct: 464 PSG----LYKTFLEELSNIQDTRKS--------------KVIEELMSSFYDYIHWINSRW 505
Query: 506 YCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVE 565
Y +E A +V + LV +++ GF+V+ + + G +++ E K
Sbjct: 506 YSREIASAVDELSYEIGKLVIDLIKNSGFEVIL--ANDFLVFVKGGSGDKLNELIFK--- 560
Query: 566 YINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAK 625
INS L L+ Y + +YA + E KI + RD E+ + + K
Sbjct: 561 -INSLYD--LNLKVRKIYRSLLILGNDRYAGLLEGDKIDIARIGKEDRDLCELVRNVKRK 617
Query: 626 VLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKR 685
V+E IL +V +AVK+VK KL + E +L+ + I + SEY P V A++
Sbjct: 618 VVEEILISKDVKKAVKLVKSAVIKLRRGEFDIGELITWVHIEKDFSEYDKQLPFVVAARK 677
Query: 686 LAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERIL 745
G + IGY++++G G + RA F +K++ D EYY++ Q+L ++L
Sbjct: 678 AIQSGYLISKDSRIGYLIVKGHGSVHDRAEPF-FFVKEKNRIDIEYYVD-QLLRESLKVL 735
Query: 746 RAFGYRKEDLK 756
G +E LK
Sbjct: 736 TPLGVSEESLK 746
>dbj|BAA99573.1| (AB037899) DNA polymerase delta catalytic chain [Oryza sativa]
Length = 1105
Score = 236 bits (595), Expect = 9e-61
Identities = 204/684 (29%), Positives = 336/684 (48%), Gaps = 73/684 (10%)
Query: 109 IFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGA 168
I +DI A R KG P ++ + +A ++ TL EG+ F + + + S + G
Sbjct: 316 ILSFDIECAGR----KGHFPEPTHDPVIQIA-NLVTLQGEGQPFVRNVMTLKSCSPIVGV 370
Query: 169 KVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI 228
V+++ +ER+++ IRE DPD+II YN FD PYL++RAE L I
Sbjct: 371 DVMSF-----------DTERDVLLAWRDFIREVDPDIIIGYNICKFDLPYLIERAEVLKI 419
Query: 229 -KLP-LGR-DNSEPKMQR---------MGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLE 276
+ P LGR NS +++ M +S V ++GR+ FDL ++R L +Y+L
Sbjct: 420 VEFPILGRIRNSRVRVRDTTFSSRQYGMRESKDVAVEGRVQFDLLQAMQRDYKLSSYSLN 479
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETGKG--LERVAKYSMEDAKVTFELGKEFFPME--AQ 332
+V G+ KE V+ H I + G R+A Y ++DA + L + + +
Sbjct: 480 SVSAHFLGEQKEDVH-HSIISDLQNGNSETRRRLAVYCLKDAYLPQRLLDKLMYIYNYVE 538
Query: 333 LARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKE 392
+AR+ G P+ + V LLRKA ++N + PN + + +++EG V E
Sbjct: 539 MARVTGVPISFLLSRGQSIKVLSQLLRKAKQKNLVIPNIKGQASGQ----DTFEGATVLE 594
Query: 393 PEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTL-NRENCKEYDVAPQV------GHRFCK 444
G +E I +LDF SLYPSI++ +N+ TL E+ ++ ++ P+ G F K
Sbjct: 595 ARAGFYEKPIATLDFASLYPSIMMAYNLCYCTLVPPEDARKLNLPPESVNKTPSGETFVK 654
Query: 445 DF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
G +P +L LL R++ K +KE+KDP E+ +LD RQ A+KI ANS YG+ G
Sbjct: 655 PDVQKGILPEILEELLAARKRAKADLKEAKDPFERAVLDGRQLALKISANSVYGFTGATV 714
Query: 503 ARWYCKECAESVTAWGRQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKH 553
+ C E + SVT++GRQ I+ ++ +E + +V+Y DTD + +
Sbjct: 715 GQLPCLEISSSVTSYGRQMIEHTKKLVEDKFTTLGGYEHNAEVIYGDTDSVMVQFGVSTV 774
Query: 554 EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGL 608
E+ + + +YI+ ++LE+E Y ++KK+YA + ++ K+ T+G+
Sbjct: 775 EDAMKLGREAADYISGTFIKPIKLEFEKIYFPYLLISKKRYAGLYWTNPEKFDKMDTKGI 834
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITR 668
E VRRD + K + L IL +V AV+ VK L + LVI + +T+
Sbjct: 835 ETVRRDNCLLVKNLVTECLHKILVDRDVPGAVQYVKNTISDLLMNRVDLSLLVITKGLTK 894
Query: 669 PLSEYKAIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEF-DP--- 722
+Y HV +A+R+ + P G + Y++++ +K A A E DP
Sbjct: 895 TGEDYAVKAAHVELAERMRKRDAATAPTVGDRVPYVIIKA----AKGAKAYERSEDPIYV 950
Query: 723 --KKHKYDAEYYIENQVLPAVERI 744
D +YY+ENQ+ + RI
Sbjct: 951 LDNNIPIDPQYYLENQISKPLLRI 974
>emb|CAC12036.1| (AL445065) DNA polymerase (PolB), large chain related protein
[Thermoplasma acidophilum]
Length = 796
Score = 229 bits (577), Expect = 1e-58
Identities = 201/753 (26%), Positives = 349/753 (45%), Gaps = 91/753 (12%)
Query: 2 IIDADYITEDGKPIIRIF-KKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHG 60
I+ A Y D + +F + +GE FRPY Y +++ D A +V + E
Sbjct: 7 IVSASYRQSD--VAVELFGRTREGESVAALYFGFRPY-YDVVEPDEAYLKVIQNDPE--- 60
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
++E + G+ V ++Y+ P VP REK ++ DIPF R+
Sbjct: 61 ----FVKMEDKRLWIRGKYENVKRIYIRSPWKVPEYREK-----CPFEVLAADIPFHHRF 111
Query: 121 LIDKGLTPM------------------------------EGNEELTFLAVDIETLYHEGE 150
+ D L + N L L+ D+E +
Sbjct: 112 IYDLDLGSCVKIIGENISDRETSFTTDIVIRADRIENVNDFNPNLKVLSFDVENEINREN 171
Query: 151 EFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYN 210
G I++I Y+ K +T + E+++++ V +IR +DPDVI YN
Sbjct: 172 VEDYGKILVIGYSVSFQGKTVTGS--------LSGEEQDILRSFVDLIRAEDPDVITGYN 223
Query: 211 GDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINL 270
D +D P + KR ++ GIKL +GRD S P+ R+ + + GR+ D + ++R ++
Sbjct: 224 IDGYDIPVIKKRMDRYGIKLEIGRDGSIPR--RIMNQFW-RVHGRLISDTWWSVKRILHP 280
Query: 271 PTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPME 330
+L+ V + G+ K+ + I + W+ K E V Y ++DA +T + ++ M
Sbjct: 281 KHESLDYVANMLLGEGKDNIDRLHIEDEWK--KRREEVIAYCIKDADLTLRIFEKLMVMN 338
Query: 331 A--QLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGG 388
++ + P+ DV+ T N V+ L+R A N P E + E +GG
Sbjct: 339 RLMYMSSVTKLPLDDVANVGTSNYVDSILIRAADRENIGVPMNQHEIK-----TEEIQGG 393
Query: 389 YVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFC--KDF 446
YV GL+ ++ LDF+S+YPS+II +NV TL+ ++ G RF +
Sbjct: 394 YVHSIGAGLYSNVIVLDFKSMYPSMIIKYNVCFTTLDPNG----EILSPNGVRFLSPEKK 449
Query: 447 PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWY 506
G IP +L L+ +R ++K+RMK +K E++ D Q AIK+L N++YG + R+
Sbjct: 450 KGLIPRILQELMADRDEVKRRMKAAKTKDEREFYDGIQNAIKVLMNTFYGVLASSFYRFT 509
Query: 507 CKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEY 566
+ ++TA+ R+ I + LES ++V+Y DTD ++ E+ ++ E
Sbjct: 510 DHKIGSAITAFARETIKGIISTLESAHYRVIYGDTDSVFVESGAGSAEDAIKRGKDLSER 569
Query: 567 INSKLPGL---LELEYEGFYARGFFVTKKKYA-----LIDEEGKIVTRGLEIVRRDWSEI 618
+ S+ GL ++ + F++ G KK+YA D +G+IV +G E+ R D ++
Sbjct: 570 L-SREQGLTLDFQMVLDPFFSHG---AKKRYAGRCVYPDDMKGEIVIKGYEVRRTDSFDL 625
Query: 619 AKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYE--IPPEKLVIYEQITRPLSEYKAI 676
+ +KV++ IL ++D A+K ++ +K+ + I + LVI + + Y+A
Sbjct: 626 QSQALSKVIDFILNR-DIDGAIKYADDLIKKVRAGDPSIDIDSLVI-SRTVKDFQSYRAN 683
Query: 677 GPHVA---VAKRLAAKGVKVKPGMVIGYIVLRG 706
+A AK+L G PGM + +IV G
Sbjct: 684 QESLANIRAAKKLIDMGETFVPGMKVSWIVTNG 716
>sp|O48901|DPOD_SOYBN DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|7434806|pir||T05731
DNA-directed DNA polymerase (EC 2.7.7.7) delta chain -
soybean >gi|2895198|gb|AAC18443.1| (AF020193) DNA
polymerase delta [Glycine max]
Length = 1088
Score = 228 bits (575), Expect = 2e-58
Identities = 204/684 (29%), Positives = 329/684 (47%), Gaps = 73/684 (10%)
Query: 109 IFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGA 168
I +DI A R KG P ++ + +A ++ TL E + F + + + S + G
Sbjct: 273 ILSFDIECAGR----KGHFPEPTHDPVIQIA-NLVTLQGEDQPFIRNVMTLKSCSPIVGV 327
Query: 169 KVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI 228
V+ +++ ERE++ IRE DPD+II YN FD PYL++RA L I
Sbjct: 328 DVMPFET-----------EREVLLAWRDFIREVDPDIIIGYNICKFDLPYLIERALNLKI 376
Query: 229 -KLP-LGR-DNSEPKMQRMG---------DSLAVEIKGRIHFDLFPVIRRTINLPTYTLE 276
+ P LGR NS +++ +S V ++GR+ FDL V++R L +Y+L
Sbjct: 377 AEFPILGRIRNSRVRVKDTTFSSRQYGTRESKEVAVEGRVTFDLLQVMQRDYKLSSYSLN 436
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETGKG--LERVAKYSMEDAKVTFELGKE--FFPMEAQ 332
+V + KE V+ H I + G R+A Y ++DA + L + F +
Sbjct: 437 SVSSHFLSEQKEDVH-HSIISDLQNGNAETRRRLAVYCLKDAYLPQRLLDKLMFIYNYVE 495
Query: 333 LARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKE 392
+AR+ G P+ + V LLR+A ++N + PN + ++EG V E
Sbjct: 496 MARVTGVPISFLLSRGQSIKVLSQLLRRARQKNLVIPNAKQAGSEQG----TFEGATVLE 551
Query: 393 PEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLN-RENCKEYDVAPQV------GHRFCK 444
G +E I +LDF SLYPSI++ +N+ TL E+ ++ ++ P+ G F K
Sbjct: 552 ARAGFYEKPIATLDFASLYPSIMMAYNLCYCTLVIPEDARKLNIPPESVNRTPSGETFVK 611
Query: 445 DF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
G +P +L LL R++ K +KE+KDP+EK +LD RQ A+KI ANS YG+ G
Sbjct: 612 SNLQKGILPEILEELLTARKRAKADLKEAKDPLEKAVLDGRQLALKISANSVYGFTGATI 671
Query: 503 ARWYCKECAESVTAWGRQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKH 553
+ C E + SVT++GRQ I+ ++ +E + +V+Y DTD + +
Sbjct: 672 GQLPCLEISSSVTSYGRQMIEHTKKLVEDKFTTLNGYEHNAEVIYGDTDSVMVQFGVSAV 731
Query: 554 EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGL 608
EE + E+I+ ++LE+E Y ++KK+YA + D K+ T+G+
Sbjct: 732 EEAMNLGREAAEHISGTFTKPIKLEFEKVYYPYLLISKKRYAGLFWTKPDNFDKMDTKGI 791
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITR 668
E VRRD + K L IL ++ AV+ VK L + LVI + +T+
Sbjct: 792 ETVRRDNCLLVKNLVNDCLHKILIDRDIPGAVQYVKNAISDLLMNRMDLSLLVITKGLTK 851
Query: 669 PLSEYKAIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEF-DP--- 722
+Y+ HV +A+R+ + P G + Y++++ +K A A E DP
Sbjct: 852 TGDDYEVKAAHVELAERMRKRDAATAPNVGDRVPYVIIKA----AKGAKAYERSEDPIYV 907
Query: 723 --KKHKYDAEYYIENQVLPAVERI 744
D YY+ENQ+ + RI
Sbjct: 908 LENNIPIDPHYYLENQISKPILRI 931
>dbj|BAA96899.1| (AB019227) DNA polymerase III catalytic subunit [Arabidopsis
thaliana]
Length = 1081
Score = 226 bits (571), Expect = 6e-58
Identities = 202/684 (29%), Positives = 321/684 (46%), Gaps = 73/684 (10%)
Query: 109 IFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGA 168
+ +DI A R KG P E + ++ TL E F + + + S A G
Sbjct: 306 VLSFDIECAGR----KGHFP-EAKHDPVIQIANLVTLQGEDHPFVRNVMTLKSCAPIVGV 360
Query: 169 KVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI 228
V+++++ ERE++ +IR+ DPD+II YN FD PYL++RA LGI
Sbjct: 361 DVMSFET-----------EREVLLAWRDLIRDVDPDIIIGYNICKFDLPYLIERAATLGI 409
Query: 229 K-LPL----------GRDNS-EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLE 276
+ PL RD++ + Q + +S I+GR FDL I R L +Y+L
Sbjct: 410 EEFPLLGRVKNSRVRVRDSTFSSRQQGIRESKETTIEGRFQFDLIQAIHRDHKLSSYSLN 469
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETGKG--LERVAKYSMEDAKVTFELGKE--FFPMEAQ 332
+V + KE V+ H I + G R+A Y ++DA + L + F +
Sbjct: 470 SVSAHFLSEQKEDVH-HSIITDLQNGNAETRRRLAVYCLKDAYLPQRLLDKLMFIYNYVE 528
Query: 333 LARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKE 392
+AR+ G P+ + V LLRK ++N + PN + +YEG V E
Sbjct: 529 MARVTGVPISFLLARGQSIKVLSQLLRKGKQKNLVLPNAKQSGSEQG----TYEGATVLE 584
Query: 393 PEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTL-NRENCKEYDVAPQ------VGHRFCK 444
G +E I +LDF SLYPSI++ +N+ TL E+ ++ ++ P+ G F K
Sbjct: 585 ARTGFYEKPIATLDFASLYPSIMMAYNLCYCTLVTPEDVRKLNLPPEHVTKTPSGETFVK 644
Query: 445 DF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
G +P +L LL R++ K +KE+KDP+EK +LD RQ A+KI ANS YG+ G
Sbjct: 645 QTLQKGILPEILEELLTARKRAKADLKEAKDPLEKAVLDGRQLALKISANSVYGFTGATV 704
Query: 503 ARWYCKECAESVTAWGRQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKH 553
+ C E + SVT++GRQ I+ ++ +E + +V+Y DTD + +
Sbjct: 705 GQLPCLEISSSVTSYGRQMIEQTKKLVEDKFTTLGGYQYNAEVIYGDTDSVMVQFGVSDV 764
Query: 554 EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGL 608
E + E+I+ ++LE+E Y + KK+YA + + K+ T+G+
Sbjct: 765 EAAMTLGREAAEHISGTFIKPIKLEFEKVYFPYLLINKKRYAGLLWTNPQQFDKMDTKGI 824
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITR 668
E VRRD + K + L IL +V A + VK+ L I LVI + +T+
Sbjct: 825 ETVRRDNCLLVKNLVTESLNKILIDRDVPGAAENVKKTISDLLMNRIDLSLLVITKGLTK 884
Query: 669 PLSEYKAIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEF-DP--- 722
+Y+ H +A+R+ + P G + Y++++ +K A A E DP
Sbjct: 885 TGDDYEVKSAHGELAERMRKRDAATAPNVGDRVPYVIIKA----AKGAKAYERSEDPIYV 940
Query: 723 --KKHKYDAEYYIENQVLPAVERI 744
D YY+ENQ+ + RI
Sbjct: 941 LQNNIPIDPNYYLENQISKPLLRI 964
>pir||S60677 DNA-directed DNA polymerase III (EC 2.7.7.7) - yeast (Candida
albicans) >gi|7428080|pir||JC5757 DNA-directed DNA
polymerase (EC 2.7.7.7) III - yeast (Candida albicans)
Length = 1038
Score = 225 bits (568), Expect = 1e-57
Identities = 196/667 (29%), Positives = 314/667 (46%), Gaps = 67/667 (10%)
Query: 135 LTFLAVDIETLYHEG--EEFGKGPIIMISYADEEGAK----------VITWKSIDLPYVE 182
L L+ DIE +G E P+I I+ ++ + V T SI +
Sbjct: 244 LRILSFDIECAGRKGVFPEAEHDPVIQIANVVQKSGESKPFVRNVFTVNTCSSIIGSQIF 303
Query: 183 VVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIK-LP----LGRDNS 237
E +M+ + I + DPDVII YN NFD PY+L RA+ LG+ P L R
Sbjct: 304 EHQREEDMLMHWKEFITKVDPDVIIGYNTANFDIPYVLNRAKALGLNDFPFFGRLKRVKQ 363
Query: 238 EPKMQRMG-------DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKV 290
E K ++ V I GR+ DL I+R L +YTL +V G+ KE V
Sbjct: 364 EIKDAVFSSRAYGTRENKVVNIDGRMQLDLLQFIQREYKLRSYTLNSVSAHFLGEQKEDV 423
Query: 291 YAHEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPV-WDVS 345
H I + G + R+A Y ++DA + L + + ++AR+ G P + +S
Sbjct: 424 Q-HSIITDLQNGTKETRRRLAVYCLKDAFLPLRLLDKLMCLVNYTEMARVTGVPFSYLLS 482
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSL 404
R ++ L RK + + + PN E E YEG V EPE+G ++ I +L
Sbjct: 483 RGQQIKVISQ-LFRKCLQEDIVIPNLKSEGS-----NEEYEGATVIEPERGYYDVPIATL 536
Query: 405 DFRSLYPSIIITHNVSPDTLNRENC--------KEYDVAPQVGHRFCKDF-PGFIPSLLG 455
DF SLYPSI++ HN+ TL +N +Y P + + G +P++L
Sbjct: 537 DFSSLYPSIMMAHNLCYTTLLNKNSIKAFGLTEDDYTKTPNGDYFVHSNLRKGILPTILD 596
Query: 456 NLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVT 515
LL R+K K +K+ DP +K +L+ RQ A+KI ANS YG+ G + C + SVT
Sbjct: 597 ELLTARKKAKADLKKETDPFKKDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVT 656
Query: 516 AWGRQYIDLVRRELES---------RGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEY 566
A+GR+ I+ + E++ KV+Y DTD + E + + Y
Sbjct: 657 AFGREMIEKTKNEVQEYYSKKNGHPYDAKVIYGDTDSVMVKFGYQDLETCMKLGEEAANY 716
Query: 567 INSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKE 621
+++K ++LE+E Y + KK+YA + ++ K+ T+G+E VRRD ++ +
Sbjct: 717 VSTKFKNPIKLEFEKVYFPYLLINKKRYAGLYWTRPEKFDKMDTKGIETVRRDNCQLVQN 776
Query: 622 TQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVA 681
KVLE IL+ +V +A + VK+ L + I +LVI + ++ +Y A HV
Sbjct: 777 VITKVLEFILEERDVPKAQRFVKQTIADLLQNRIDLSQLVITKAYSK--HDYSAKQAHVE 834
Query: 682 VAKRLAAKGVKVKP--GMVIGYIVLR--GDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
+A+R+ + P G + Y++++ GD K + + D +YY++ Q+
Sbjct: 835 LAERMRKRDPGSAPTLGDRVAYVIIKTGGDKNYEKSEDPLYVLE-NSLPIDVKYYLDQQL 893
Query: 738 LPAVERI 744
+ERI
Sbjct: 894 TKPLERI 900
>sp|P46588|DPOD_CANAL DNA POLYMERASE DELTA LARGE CHAIN (DNA POLYMERASE III)
>gi|951001|emb|CAA61282.1| (X88804) DNA-directed DNA
polymerase III [Candida albicans]
Length = 1038
Score = 225 bits (568), Expect = 1e-57
Identities = 196/667 (29%), Positives = 314/667 (46%), Gaps = 67/667 (10%)
Query: 135 LTFLAVDIETLYHEG--EEFGKGPIIMISYADEEGAK----------VITWKSIDLPYVE 182
L L+ DIE +G E P+I I+ ++ + V T SI +
Sbjct: 244 LRILSFDIECAGRKGVFPEAEHDPVIQIANVVQKSGESKPFVRNVFTVNTCSSIIGSQIF 303
Query: 183 VVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIK-LP----LGRDNS 237
E +M+ + I + DPDVII YN NFD PY+L RA+ LG+ P L R
Sbjct: 304 EHQREEDMLMHWKEFITKVDPDVIIGYNTANFDIPYVLNRAKALGLNDFPFFGRLKRVKQ 363
Query: 238 EPKMQRMG-------DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKV 290
E K ++ V I GR+ DL I+R L +YTL +V G+ KE V
Sbjct: 364 EIKDAVFSSRAYGTRENKVVNIDGRMQLDLLQFIQREYKLRSYTLNSVSAHFLGEQKEDV 423
Query: 291 YAHEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPV-WDVS 345
H I + G + R+A Y ++DA + L + + ++AR+ G P + +S
Sbjct: 424 Q-HSIITDLQNGTKETRRRLAVYCLKDAFLPLRLLDKLMCLVNYTEMARVTGVPFSYLLS 482
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSL 404
R ++ L RK + + + PN E E YEG V EPE+G ++ I +L
Sbjct: 483 RGQQIKVISQ-LFRKCLQEDIVIPNLKSEGS-----NEEYEGATVIEPERGYYDVPIATL 536
Query: 405 DFRSLYPSIIITHNVSPDTLNRENC--------KEYDVAPQVGHRFCKDF-PGFIPSLLG 455
DF SLYPSI++ HN+ TL +N +Y P + + G +P++L
Sbjct: 537 DFSSLYPSIMMAHNLCYTTLLNKNSIKAFGLTEDDYTKTPNGDYFVHSNLRKGILPTILD 596
Query: 456 NLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVT 515
LL R+K K +K+ DP +K +L+ RQ A+KI ANS YG+ G + C + SVT
Sbjct: 597 ELLTARKKAKADLKKETDPFKKDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVT 656
Query: 516 AWGRQYIDLVRRELES---------RGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEY 566
A+GR+ I+ + E++ KV+Y DTD + E + + Y
Sbjct: 657 AFGREMIEKTKNEVQEYYSKKNGHPYDAKVIYGDTDSVMVKFGYQDLETCMKLGEEAANY 716
Query: 567 INSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKE 621
+++K ++LE+E Y + KK+YA + ++ K+ T+G+E VRRD ++ +
Sbjct: 717 VSTKFKNPIKLEFEKVYFPYLLINKKRYAGLYWTRPEKFDKMDTKGIETVRRDNCQLVQN 776
Query: 622 TQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVA 681
KVLE IL+ +V +A + VK+ L + I +LVI + ++ +Y A HV
Sbjct: 777 VITKVLEFILEERDVPKAQRFVKQTIADLLQNRIDLSQLVITKAYSK--HDYSAKQAHVE 834
Query: 682 VAKRLAAKGVKVKP--GMVIGYIVLR--GDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
+A+R+ + P G + Y++++ GD K + + D +YY++ Q+
Sbjct: 835 LAERMRKRDPGSAPTLGDRVAYVIIKTGGDKNYEKSEDPLYVLE-NSLPIDVKYYLDQQL 893
Query: 738 LPAVERI 744
+ERI
Sbjct: 894 TKPLERI 900
>pir||T18222 DNA polymerase delta chain - yeast (Candida albicans)
>gi|3850149|emb|CAA21949.1| (AL033396) DNA polymerase
delta [Candida albicans]
Length = 1038
Score = 224 bits (566), Expect = 2e-57
Identities = 196/667 (29%), Positives = 313/667 (46%), Gaps = 67/667 (10%)
Query: 135 LTFLAVDIETLYHEG--EEFGKGPIIMISYADEEGAK----------VITWKSIDLPYVE 182
L L+ DIE +G E P+I I+ ++ + V T SI +
Sbjct: 244 LRILSFDIECAGRKGVFPEAEHDPVIQIANVVQKSGESKPFVRNVFTVNTCSSIIGSQIF 303
Query: 183 VVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIK-LP----LGRDNS 237
E +M+ + I + DPDVII YN NFD PY+L RA+ LG+ P L R
Sbjct: 304 EHQREEDMLMHWKEFITKVDPDVIIGYNTANFDIPYVLNRAKALGLNDFPFFGRLKRVKQ 363
Query: 238 EPKMQRMG-------DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKV 290
E K ++ V I GR+ DL I+R L +YTL +V G+ KE V
Sbjct: 364 EIKDAVFSSRAYGTRENKVVNIDGRMQLDLLQFIQREYKLRSYTLNSVSAHFLGEQKEDV 423
Query: 291 YAHEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPV-WDVS 345
H I + G + R+A Y ++DA + L + + ++AR+ G P + +S
Sbjct: 424 Q-HSIITDLQNGTKETRRRLAVYCLKDAFLPLRLLDKLMCLVNYTEMARVTGVPFSYLLS 482
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSL 404
R ++ L RK + + + PN E E YEG V EPE+G ++ I +L
Sbjct: 483 RGQQIKVISQ-LFRKCLQEDIVIPNLKSEGS-----NEEYEGATVIEPERGYYDVPIATL 536
Query: 405 DFRSLYPSIIITHNVSPDTLNRENC--------KEYDVAPQVGHRFCKDF-PGFIPSLLG 455
DF SLYPSI++ HN+ TL +N +Y P + + G +P++L
Sbjct: 537 DFSSLYPSIMMAHNLCYTTLLNKNSIKAFGLTEDDYTKTPNGDYFVHSNLRKGILPTILD 596
Query: 456 NLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVT 515
LL R+K K +K+ DP +K +L+ RQ A+KI ANS YG+ G + C + SVT
Sbjct: 597 ELLTARKKAKADLKKETDPFKKDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVT 656
Query: 516 AWGRQYIDLVRRELES---------RGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEY 566
A+GR+ I+ + E++ KV+Y DTD + E + + Y
Sbjct: 657 AFGREMIEKTKNEVQEYYSKKNGHPYDAKVIYGDTDSVMVKFGYQDLETCMKLGEEAANY 716
Query: 567 INSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKE 621
+++K ++LE+E Y + KK+YA + ++ K+ T+G+E VRRD + +
Sbjct: 717 VSTKFKNPIKLEFEKVYFPYLLINKKRYAGLYWTRPEKFDKMDTKGIETVRRDNCRLVQN 776
Query: 622 TQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVA 681
KVLE IL+ +V +A + VK+ L + I +LVI + ++ +Y A HV
Sbjct: 777 VITKVLEFILEERDVPKAQRFVKQTIADLLQNRIDLSQLVITKAYSK--HDYSAKQAHVE 834
Query: 682 VAKRLAAKGVKVKP--GMVIGYIVLR--GDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
+A+R+ + P G + Y++++ GD K + + D +YY++ Q+
Sbjct: 835 LAERMRKRDPGSAPTLGDRVAYVIIKTGGDKNYEKSEDPLYVLE-NSLPIDVKYYLDQQL 893
Query: 738 LPAVERI 744
+ERI
Sbjct: 894 TKPLERI 900
>emb|CAB97239.1| (AL117202) similar to DNA polymerase alpha subunit [Caenorhabditis
elegans]
Length = 1443
Score = 224 bits (566), Expect = 2e-57
Identities = 183/607 (30%), Positives = 307/607 (50%), Gaps = 52/607 (8%)
Query: 180 YVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLP----LGRD 235
+V+ V++E+ ++ + +I E +PD+I+ ++ + L+ R EKL KLP + R
Sbjct: 594 FVKSVANEKALLTLFLAMINEDEPDMIVGHDL-SATIALLVSRLEKL--KLPNWSRISRL 650
Query: 236 NSEPKMQRMGDSLAVEIK---GRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
+ ++G S + + + GR+ D + ++ L + + I G + ++YA
Sbjct: 651 KRSINIGKIGHSKSGQWELTAGRMMLDSKLAAMELVKSRSFDLTELSQQILGAERREIYA 710
Query: 293 HEIAEAWETGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTG 350
+EI + + K L + +S D ++ + P+ Q++++VG SR+ G
Sbjct: 711 NEIPQLYVDSKDLISLINWSWNDLLLSLRIVVRLNALPLYIQISQIVGGIA---SRTMMG 767
Query: 351 NLVEW--FLLRKAYERNEL-APNKPDEREYERRLRES------------YEGGYVKEPEK 395
E +LL A+E+ +L AP+K + E +++ ES Y GG V EP+K
Sbjct: 768 GRAERNEYLLLHAFEKADLIAPDKYNSSESKKKKEESQEGDEKKSGKAQYSGGLVLEPKK 827
Query: 396 GLWEGIVSL-DFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLL 454
GL+E ++ L DF SLYPSII +N+ TL E K+ D Q+ D G +P +
Sbjct: 828 GLYETLILLLDFNSLYPSIIQEYNICYTTL--EYSKDSD--EQLSVPQSTDIEGVLPREI 883
Query: 455 GNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESV 514
L+E R+ +K MK ++ +KK +D RQ A+K+ ANS YG G+ +R+Y K A V
Sbjct: 884 RKLVECRRDVKSLMKSERNEAKKKQMDIRQMALKLTANSMYGCLGFQYSRFYAKPLAALV 943
Query: 515 TAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGL 574
TA GR+ + + +E G+ V+Y DTD + K+ + + +N K L
Sbjct: 944 TAKGREILMHSKDLVEKMGYSVVYGDTDSIMINTNSVDLVAAKKLGNEIKKAVN-KCHRL 1002
Query: 575 LELEYEGFYARGFFVTKKKYA--LIDEEGKIVT---RGLEIVRRDWSEIAKETQAKVLEA 629
LEL+ +G + R + KKKYA I+ + K+ +GL+IVRRDWS++AKET V++
Sbjct: 1003 LELDLDGVFKRMLLLKKKKYAALTINPDTKVEAKELKGLDIVRRDWSQLAKETGTAVVDK 1062
Query: 630 ILKHG-NVDEAVK----IVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGP--HVAV 682
IL DE V +++E+ KL +P E I +Q+TR +Y + H AV
Sbjct: 1063 ILDASLTRDEMVSSIDDLLREIRAKLDSGTVPLEMFQISKQLTRNPEQYADVKAQCHAAV 1122
Query: 683 AKRLAAKG-VKVKPGMVIGYIVLRG--DGPISKRAI-AIEEFDPKKHKYDAEYYIENQVL 738
A+RL G ++ ++ Y++ D P ++RA E + K D YY+ Q+
Sbjct: 1123 AQRLNKSGKFNLRHNDIVEYVICEDGTDNPATQRAYHRTEMAENSALKIDLLYYLAQQIH 1182
Query: 739 PAVERIL 745
P V R++
Sbjct: 1183 PVVSRLV 1189
>sp|P52431|DPOD_MOUSE DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|481948|pir||S40243
DNA-directed DNA polymerase (EC 2.7.7.7) delta chain -
mouse >gi|438134|emb|CAA79895.1| (Z21848) DNA-directed
DNA polymerase [Mus musculus]
Length = 1105
Score = 222 bits (561), Expect = 9e-57
Identities = 208/728 (28%), Positives = 330/728 (44%), Gaps = 83/728 (11%)
Query: 68 VEKVQKKFLGRPIEV---WKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDK 124
V + +KK +EV W + HP E + A + + +DI A R K
Sbjct: 272 VRRAEKKATLCQLEVDVLWSDVISHPP------EGQWQRIAPLRVLSFDIECAGR----K 321
Query: 125 GLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVV 184
G+ P E + + + E E F + + + A GAKV +++
Sbjct: 322 GIFP-EPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYER--------- 371
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI-KLP-LGR-------- 234
E ++++ I DPDVI YN NFD PYL+ RA+ L + + P LGR
Sbjct: 372 --EEDLLQAWADFILAMDPDVITGYNIQNFDLPYLISRAQALKVDRFPFLGRVTGLRSNI 429
Query: 235 DNSEPKMQRMG--DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
+S + +++G DS + + GR+ D+ V+ R L +YTL AV G+ KE V
Sbjct: 430 RDSSFQSRQVGRRDSKVISMVGRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQ- 488
Query: 293 HEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPVWDVSRSS 348
H I + G + R+A Y ++DA + L + + ++AR+ G P+ +
Sbjct: 489 HSIITDLQNGNEQTRRRLAVYCLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLTRG 548
Query: 349 TGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFR 407
V LLR+A + L P E E Y G V EP KG ++ I +LDF
Sbjct: 549 QQVKVVSQLLRQAMRQGLLMPVVKTEGG------EDYTGATVIEPLKGYYDVPIATLDFS 602
Query: 408 SLYPSIIITHNVSPDTLNRENCKEY-------DVAPQVGHRFCKDF--PGFIPSLLGNLL 458
SLYPSI++ HN+ TL R + + G F K G +P +L NLL
Sbjct: 603 SLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFVKSSVRKGLLPQILENLL 662
Query: 459 EERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWG 518
R++ K + + DP+ +++LD RQ A+K+ ANS YG+ G + C E ++SVT +G
Sbjct: 663 SARKRAKAELAQETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFG 722
Query: 519 RQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINS 569
RQ I+ ++ +ES+ KV+Y DTD + + E + +++S
Sbjct: 723 RQMIEKTKQLVESKYTVENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSS 782
Query: 570 KLPGLLELEYEGFYARGFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKETQ 623
P + LE+E Y ++KK+YA + D K+ +GLE VRRD +
Sbjct: 783 HFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRSDAHDKMDCKGLEAVRRDNCPLVANLV 842
Query: 624 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVA 683
L IL + D AV K+V L I +LVI +++TR ++Y HV +A
Sbjct: 843 TSSLRRILVDRDPDGAVAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVELA 902
Query: 684 KRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFDP---KKHK--YDAEYYIENQ 736
+R+ + P G + Y+++ G A ++ DP +H D +YY+E Q
Sbjct: 903 ERMRKRDPGSAPSLGDRVPYVII---GAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQ 959
Query: 737 VLPAVERI 744
+ + RI
Sbjct: 960 LAKPLLRI 967
>pir||T40242 DNA polymerase delta large chain - fission yeast
(Schizosaccharomyces pombe) >gi|6048293|emb|CAB58156.1|
(AL121815) DNA polymerase delta large chain
[Schizosaccharomyces pombe]
Length = 1086
Score = 222 bits (561), Expect = 9e-57
Identities = 202/688 (29%), Positives = 316/688 (45%), Gaps = 75/688 (10%)
Query: 105 AVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYAD 164
A + I +DI A R KG+ P + + +A I T Y + F + + + +
Sbjct: 292 APLRIMSFDIECAGR----KGVFPDPSIDPVIQIA-SIVTQYGDSTPFVRNVFCVDTCSQ 346
Query: 165 EEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE 224
G +V +++ + EM+ K +R+ DPDV+I YN NFD PYLL RA+
Sbjct: 347 IVGTQVYEFQN-----------QAEMLSSWSKFVRDVDPDVLIGYNICNFDIPYLLDRAK 395
Query: 225 KLGI-KLPL-GRDNS----------EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPT 272
L I PL GR ++ K +S I GR+ D+ V++R L +
Sbjct: 396 SLRIHNFPLLGRIHNFFSVAKETTFSSKAYGTRESKTTSIPGRLQLDMLQVMQRDFKLRS 455
Query: 273 YTLEAVYEAIFGKSKEKVYAHEIAEAWE-TGKGLERVAKYSMEDAKVTFELGKEF--FPM 329
Y+L AV G+ KE V+ I + T R+A Y ++DA + L + F
Sbjct: 456 YSLNAVCSQFLGEQKEDVHYSIITDLQNGTADSRRRLAIYCLKDAYLPQRLMDKLMCFVN 515
Query: 330 EAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGY 389
++AR+ G P + V L RKA + + + PN E YEG
Sbjct: 516 YTEMARVTGVPFNFLLARGQQIKVISQLFRKALQHDLVVPNIR-----VNGTDEQYEGAT 570
Query: 390 VKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKE---------YDVAPQVG 439
V EP KG ++ I +LDF SLYPSI+ HN+ TL N E Y V P G
Sbjct: 571 VIEPIKGYYDTPIATLDFSSLYPSIMQAHNLCYTTLLDSNTAELLKLKQDVDYSVTPN-G 629
Query: 440 HRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGY 497
F K G +P +L +LL R+K K +K+ DP +K +LD RQ A+K+ ANS YG+
Sbjct: 630 DYFVKPHVRKGLLPIILADLLNARKKAKADLKKETDPFKKAVLDGRQLALKVSANSVYGF 689
Query: 498 YGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-----GFK----VLYIDTDGLYATI 548
G R C + SVT++GRQ I+ + +E R G+ V+Y DTD +
Sbjct: 690 TGATNGRLPCLAISSSVTSYGRQMIEKTKDVVEKRYRIENGYSHDAVVIYGDTDSVMVKF 749
Query: 549 PGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKI 603
E + + Y++ + P ++LE+E Y ++KK+YA + D K+
Sbjct: 750 GVKTLPEAMKLGEEAANYVSDQFPNPIKLEFEKVYFPYLLISKKRYAGLFWTRTDTYDKM 809
Query: 604 VTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIY 663
++G+E VRRD + L +L +V+ A K+V L + +I +LVI
Sbjct: 810 DSKGIETVRRDNCPLVSYVIDTALRKMLIDQDVEGAQLFTKKVISDLLQNKIDMSQLVIT 869
Query: 664 EQITRPLSEYKAIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFD 721
+ +++ ++Y A HV +A+R+ + P G + Y++++G + D
Sbjct: 870 KALSK--TDYAAKMAHVELAERMRKRDAGSAPAIGDRVAYVIIKG---AQGDQFYMRSED 924
Query: 722 P-----KKHKYDAEYYIENQVLPAVERI 744
P DA+YY+ENQ+ + RI
Sbjct: 925 PIYVLENNIPIDAKYYLENQLSKPLLRI 952
>gi|6755122 DNA polymerase delta 1, catalytic domain [Mus musculus]
>gi|2827903|gb|AAB99910.1| (AF024570) DNA polymerase
delta catalytic subunit [Mus musculus]
Length = 1105
Score = 221 bits (557), Expect = 3e-56
Identities = 207/728 (28%), Positives = 330/728 (44%), Gaps = 83/728 (11%)
Query: 68 VEKVQKKFLGRPIEV---WKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDK 124
V + +KK +EV W + HP E + A + + +DI A R K
Sbjct: 272 VRRAEKKATLCQLEVDVLWSDVISHPP------EGQWQRIAPLRVLSFDIECAGR----K 321
Query: 125 GLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVV 184
G+ P E + + + E E F + + + A GAKV +++
Sbjct: 322 GIFP-EPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYER--------- 371
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI-KLP-LGR-------- 234
E ++++ I DPDVI YN NFD PYL+ RA+ L + + P LGR
Sbjct: 372 --EEDLLQAWADFILAMDPDVITGYNIQNFDLPYLISRAQALKVDRFPFLGRVTGLRSNI 429
Query: 235 DNSEPKMQRMG--DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
+S + +++G DS + + GR+ D+ V+ R L +YTL AV G+ KE V
Sbjct: 430 RDSSFQSRQVGRRDSKVISMVGRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQ- 488
Query: 293 HEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPVWDVSRSS 348
H I + G + R+A Y ++DA + L + + ++AR+ G P+ +
Sbjct: 489 HSIITDLQNGNEQTRRRLAVYCLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLTRG 548
Query: 349 TGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFR 407
V LLR+A + L P E E Y G V EP KG ++ I +LDF
Sbjct: 549 QQVKVVSQLLRQAMRQGLLMPVVKTEGG------EDYTGATVIEPLKGYYDVPIATLDFS 602
Query: 408 SLYPSIIITHNVSPDTLNRENCKEY-------DVAPQVGHRFCKDF--PGFIPSLLGNLL 458
SLYPSI++ HN+ TL R + + G F K G +P +L NLL
Sbjct: 603 SLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFVKSSVRKGLLPQILENLL 662
Query: 459 EERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWG 518
R++ K + + DP+ +++LD RQ A+K+ ANS YG+ G + C E ++SVT +G
Sbjct: 663 SARKRAKAELAQETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFG 722
Query: 519 RQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINS 569
RQ I+ ++ +ES+ KV+Y DTD + + E + +++S
Sbjct: 723 RQMIEKTKQLVESKYTVENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSS 782
Query: 570 KLPGLLELEYEGFYARGFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKETQ 623
P + LE++ Y ++KK+YA + D K+ +GLE VRRD +
Sbjct: 783 HFPSPIRLEFKKVYFPYLLISKKRYAGLLFSSRSDAHDKMDCKGLEAVRRDNCPLVANLV 842
Query: 624 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVA 683
L IL + D AV K+V L I +LVI +++TR ++Y HV +A
Sbjct: 843 TSSLRRILVDRDPDGAVAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVELA 902
Query: 684 KRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFDP---KKHK--YDAEYYIENQ 736
+R+ + P G + Y+++ G A ++ DP +H D +YY+E Q
Sbjct: 903 ERMRKRDPGSAPSLGDRVPYVII---GAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQ 959
Query: 737 VLPAVERI 744
+ + RI
Sbjct: 960 LAKPLLRI 967
>pir||S35455 DNA-directed DNA polymerase (EC 2.7.7.7) delta - human
>gi|181622|gb|AAA35768.1| (M81735) DNA polymerase delta
[Homo sapiens]
Length = 1107
Score = 220 bits (555), Expect = 4e-56
Identities = 200/709 (28%), Positives = 324/709 (45%), Gaps = 76/709 (10%)
Query: 82 VWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVD 141
+W + HP + P R A + + +DI A R KG+ P E +
Sbjct: 291 LWSDVVSHPPEGPWQRI------APLRVLSFDIECAGR----KGIFP-EPERDPVIQICS 339
Query: 142 IETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREK 201
+ + E E F + + + A GAKV +++ E ++++ IR
Sbjct: 340 LGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEK-----------EEDLLQAWSTFIRIM 388
Query: 202 DPDVIITYNGDNFDFPYLLKRAEKLGIK-LP-LGR---------DNS-EPKMQRMGDSLA 249
DPDVI YN NFD PYL+ RA+ L ++ P LGR D+S + K D+
Sbjct: 389 DPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKV 448
Query: 250 VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGL--ER 307
V + GR+ D+ V+ R L +YTL AV G+ KE V H I + G R
Sbjct: 449 VSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQ-HSIITDLQNGNDQTRRR 507
Query: 308 VAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPV-WDVSRSSTGNLVEWFLLRKAYER 364
+A Y ++DA + L + + ++AR+ G P+ + +SR +V LLR+A
Sbjct: 508 LAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQ-LLRQAMHE 566
Query: 365 NELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFRSLYPSIIITHNVSPDT 423
L P E E Y G V EP KG ++ I +LDF SLYPSI++ HN+ T
Sbjct: 567 GLLMPVVKSEGG------EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTT 620
Query: 424 LNRENC-------KEYDVAPQVGHRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDP 474
L R ++ + G F K G +P +L NLL R++ K + + DP
Sbjct: 621 LLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDP 680
Query: 475 VEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-- 532
+ +++LD RQ A+K+ ANS YG+ G + C E ++SVT +GRQ I+ ++ +ES+
Sbjct: 681 LRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYT 740
Query: 533 -------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYAR 585
KV+Y DTD + + E + ++++ P + LE+E Y
Sbjct: 741 VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGGEAADWVSGHFPSPIRLEFEKVYFP 800
Query: 586 GFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEA 639
++KK+YA + D ++ +GLE VRRD + L +L + + A
Sbjct: 801 YLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGA 860
Query: 640 VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKP--GM 697
V ++V L I +LVI +++TR S+Y HV +A+R+ + P G
Sbjct: 861 VAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGD 920
Query: 698 VIGYIVLRGDGPISKRAIAIEEFDPKKHK--YDAEYYIENQVLPAVERI 744
+ Y+++ ++ + + +H D +YY+E Q+ + RI
Sbjct: 921 RVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRI 969
>pir||T43266 DNA-directed DNA polymerase (EC 2.7.7.7) delta chain - fission
yeast (Schizosaccharomyces pombe)
>gi|173384|gb|AAA35303.1| (L07734) DNA polymerase delta
[Schizosaccharomyces pombe]
Length = 1086
Score = 219 bits (553), Expect = 7e-56
Identities = 201/688 (29%), Positives = 315/688 (45%), Gaps = 75/688 (10%)
Query: 105 AVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYAD 164
A + I +DI A R KG+ P + + +A I T Y + F + + + +
Sbjct: 292 APLRIMSFDIECAGR----KGVFPDPSIDPVIQIA-SIVTQYGDSTPFVRNVFCVDTCSQ 346
Query: 165 EEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE 224
G +V +++ + EM+ K +R+ DPDV+I YN NFD PYLL RA+
Sbjct: 347 IVGTQVYEFQN-----------QAEMLSSWSKFVRDVDPDVLIGYNICNFDIPYLLDRAK 395
Query: 225 KLGI-KLPL-GRDNS----------EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPT 272
L I PL GR ++ K +S I GR+ D+ V++R L +
Sbjct: 396 SLRIHNFPLLGRIHNFFSVAKETTFSSKAYGTRESKTTSIPGRLQLDMLQVMQRDFKLRS 455
Query: 273 YTLEAVYEAIFGKSKEKVYAHEIAEAWE-TGKGLERVAKYSMEDAKVTFELGKEF--FPM 329
Y+L AV G+ KE V+ I + T R+A Y ++DA + L + F
Sbjct: 456 YSLNAVCSQFLGEQKEDVHYSIITDLQNGTADSRRRLAIYCLKDAYLPQRLMDKLMCFVN 515
Query: 330 EAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGY 389
++AR+ G P + V L KA + + + PN E YEG
Sbjct: 516 YTEMARVTGVPFNFLLARGQQIKVISQLFCKALQHDLVVPNIR-----VNGTDEQYEGAT 570
Query: 390 VKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKE---------YDVAPQVG 439
V EP KG ++ I +LDF SLYPSI+ HN+ TL N E Y V P G
Sbjct: 571 VIEPIKGYYDTPIATLDFSSLYPSIMQAHNLCYTTLLDSNTAELLKLKQDVDYSVTPN-G 629
Query: 440 HRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGY 497
F K G +P +L +LL R+K K +K+ DP +K +LD RQ A+K+ ANS YG+
Sbjct: 630 DYFVKPHVRKGLLPIILADLLNARKKAKADLKKETDPFKKAVLDGRQLALKVSANSVYGF 689
Query: 498 YGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-----GFK----VLYIDTDGLYATI 548
G R C + SVT++GRQ I+ + +E R G+ V+Y DTD +
Sbjct: 690 TGATNGRLPCLAISSSVTSYGRQMIEKTKDVVEKRYRIENGYSHDAVVIYGDTDSVMVKF 749
Query: 549 PGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKI 603
E + + Y++ + P ++LE+E Y ++KK+YA + D K+
Sbjct: 750 GVKTLPEAMKLGEEAANYVSDQFPNPIKLEFEKVYFPYLLISKKRYAGLFWTRTDTYDKM 809
Query: 604 VTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIY 663
++G+E VRRD + L +L +V+ A K+V L + +I +LVI
Sbjct: 810 DSKGIETVRRDNCPLVSYVIDTALRKMLIDQDVEGAQLFTKKVISDLLQNKIDMSQLVIT 869
Query: 664 EQITRPLSEYKAIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFD 721
+ +++ ++Y A HV +A+R+ + P G + Y++++G + D
Sbjct: 870 KALSK--TDYAAKMAHVELAERMRKRDAGSAPAIGDRVAYVIIKG---AQGDQFYMRSED 924
Query: 722 P-----KKHKYDAEYYIENQVLPAVERI 744
P DA+YY+ENQ+ + RI
Sbjct: 925 PIYVLENNIPIDAKYYLENQLSKPLLRI 952
>gi|11067381 DNA polymerase delta, catalytic subunit [Rattus norvegicus]
>gi|3913500|sp|O54747|DPOD_RAT DNA POLYMERASE DELTA
CATALYTIC CHAIN >gi|2687728|emb|CAA10946.1| (AJ222691)
DNA polymerase delta, catalytic subunit [Rattus
norvegicus]
Length = 1103
Score = 219 bits (553), Expect = 7e-56
Identities = 208/729 (28%), Positives = 332/729 (45%), Gaps = 85/729 (11%)
Query: 68 VEKVQKKFLGRPIEV---WKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDK 124
V + +KK +EV W + HP E + A + + +DI A R K
Sbjct: 270 VRRAEKKATLCQLEVDVLWSDVISHPP------EGQWQRIAPLRVLSFDIECAGR----K 319
Query: 125 GLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVV 184
G+ P E + + + E E F + + + A GAKV +++
Sbjct: 320 GIFP-EPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYER--------- 369
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI-KLP-LGR-------- 234
E ++++ I DPDVI YN NFD PYL+ RA+ L + + P LGR
Sbjct: 370 --EEDLLQAWATFILAMDPDVITGYNIQNFDLPYLISRAQTLKVDRFPFLGRVTGLRSNI 427
Query: 235 DNSEPKMQRMG--DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
+S + +++G DS V + GR+ D+ V+ R L +YTL AV G+ KE V
Sbjct: 428 RDSSFQSRQVGRRDSKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQ- 486
Query: 293 HEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPV-WDVSRS 347
H I + G + R+A Y ++DA + L + + ++AR+ G P+ + +SR
Sbjct: 487 HSIITDLQNGNEQTRRRLAVYCLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRG 546
Query: 348 STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDF 406
+V LLR+A L P E E Y G V EP KG ++ I +LDF
Sbjct: 547 QQVKVVSQ-LLRQAMREGLLMPVVKTEGG------EDYTGATVIEPLKGYYDVPIATLDF 599
Query: 407 RSLYPSIIITHNVSPDTLNRENCKEY-------DVAPQVGHRFCKDF--PGFIPSLLGNL 457
SLYPSI++ HN+ TL R + + G F K G +P +L NL
Sbjct: 600 SSLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFVKASVRKGLLPQILENL 659
Query: 458 LEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAW 517
L R++ K + + DP+ +++LD RQ A+K+ NS YG+ G + C E ++SVT +
Sbjct: 660 LSARKRAKAELAQETDPLRRQVLDGRQLALKVSPNSVYGFTGAQVGKLPCLEISQSVTGF 719
Query: 518 GRQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
GRQ I+ ++ +E++ KV+Y DTD + + E + +++
Sbjct: 720 GRQMIEKTKQLVETKYTLENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVS 779
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKET 622
S P + LE+E Y ++KK+YA + D ++ +GLE VRRD +
Sbjct: 780 SHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRSDAHDRMDCKGLEAVRRDNCPLVANL 839
Query: 623 QAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAV 682
L IL + D AV K+V L I +LVI +++TR ++Y HV +
Sbjct: 840 VTSSLRRILVDRDPDGAVAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVEL 899
Query: 683 AKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFDP---KKHK--YDAEYYIEN 735
A+R+ + P G + Y+++ G A ++ DP +H D +YY+E
Sbjct: 900 AERMRKRDPGSAPNLGDRVPYVII---GAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ 956
Query: 736 QVLPAVERI 744
Q+ + RI
Sbjct: 957 QLAKPLLRI 965
>gi|4505933 polymerase (DNA directed), delta 1, catalytic subunit (125kD);
Polymerase (DNA directed), delta 1, catalytic subunit
[Homo sapiens] >gi|118839|sp|P28340|DPOD_HUMAN DNA
POLYMERASE DELTA CATALYTIC CHAIN >gi|105873|pir||A41618
DNA-directed DNA polymerase (EC 2.7.7.7) delta catalytic
chain - human >gi|181620|gb|AAA58439.1| (M80397) DNA
polymerase-delta catalytic-subunit [Homo sapiens]
Length = 1107
Score = 219 bits (552), Expect = 1e-55
Identities = 199/709 (28%), Positives = 324/709 (45%), Gaps = 76/709 (10%)
Query: 82 VWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVD 141
+W + HP + P R A + + +DI A R KG+ P E +
Sbjct: 291 LWSDVVSHPPEGPWQRI------APLRVLSFDIECAGR----KGIFP-EPERDPVIQICS 339
Query: 142 IETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREK 201
+ + E E F + + + A GAKV +++ E ++++ IR
Sbjct: 340 LGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEK-----------EEDLLQAWSTFIRIM 388
Query: 202 DPDVIITYNGDNFDFPYLLKRAEKLGIK-LP-LGR---------DNS-EPKMQRMGDSLA 249
DPDVI YN NFD PYL+ RA+ L ++ P LGR D+S + K D+
Sbjct: 389 DPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKV 448
Query: 250 VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGL--ER 307
V + GR+ D+ V+ R L ++TL AV G+ KE V H I + G R
Sbjct: 449 VSMVGRVQMDMLQVLLREYKLRSHTLNAVSFHFLGEQKEDVQ-HSIITDLQNGNDQTRRR 507
Query: 308 VAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPV-WDVSRSSTGNLVEWFLLRKAYER 364
+A Y ++DA + L + + ++AR+ G P+ + +SR +V LLR+A
Sbjct: 508 LAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQ-LLRQAMHE 566
Query: 365 NELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFRSLYPSIIITHNVSPDT 423
L P E E Y G V EP KG ++ I +LDF SLYPSI++ HN+ T
Sbjct: 567 GLLMPVVKSEGG------EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTT 620
Query: 424 LNRENC-------KEYDVAPQVGHRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDP 474
L R ++ + G F K G +P +L NLL R++ K + + DP
Sbjct: 621 LLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDP 680
Query: 475 VEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-- 532
+ +++LD RQ A+K+ ANS YG+ G + C E ++SVT +GRQ I+ ++ +ES+
Sbjct: 681 LRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYT 740
Query: 533 -------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYAR 585
KV+Y DTD + + E + ++++ P + LE+E Y
Sbjct: 741 VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFP 800
Query: 586 GFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEA 639
++KK+YA + D ++ +GLE VRRD + L +L + + A
Sbjct: 801 YLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGA 860
Query: 640 VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKP--GM 697
V ++V L I +LVI +++TR S+Y HV +A+R+ + P G
Sbjct: 861 VAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGD 920
Query: 698 VIGYIVLRGDGPISKRAIAIEEFDPKKHK--YDAEYYIENQVLPAVERI 744
+ Y+++ ++ + + +H D +YY+E Q+ + RI
Sbjct: 921 RVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRI 969
>sp|P97283|DPOD_MESAU DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|1840089|gb|AAB47254.1|
(U83704) DNA polymerase delta catalytic subunit
[Mesocricetus auratus]
Length = 1103
Score = 219 bits (552), Expect = 1e-55
Identities = 209/729 (28%), Positives = 332/729 (44%), Gaps = 85/729 (11%)
Query: 68 VEKVQKKFLGRPIEV---WKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDK 124
V + +KK +EV W + HP E + A + + +DI A R K
Sbjct: 270 VWRTEKKATQCQLEVDVLWSDVISHPP------EGQWQRIAPLRVLSFDIECAGR----K 319
Query: 125 GLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVV 184
G+ P E + + + E E F + + + A GAKV +++
Sbjct: 320 GIFP-EPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYER--------- 369
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI-KLP-LGR-------- 234
E ++++ I DPDVI YN NFD PYL+ RA+ L + + P LGR
Sbjct: 370 --EEDLLQAWPNFILAMDPDVITGYNIQNFDLPYLISRAQTLKVDRFPFLGRVTGLRSNI 427
Query: 235 DNSEPKMQRMG--DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
+S + +++G DS V + GR+ D+ V+ R L +YTL AV G+ KE V
Sbjct: 428 RDSSFQSRQVGRRDSKVVSMVGRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQ- 486
Query: 293 HEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPV-WDVSRS 347
H I + G + R+A Y + DA + L + + ++AR+ G P+ + +SR
Sbjct: 487 HSIITDLQNGNEQTRRRLAVYCLRDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRG 546
Query: 348 STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDF 406
+V LLR+A + L P E E Y G V EP KG ++ I +LDF
Sbjct: 547 QQVKVVSQ-LLRQAMRQGLLMPVVKTEGG------EDYTGATVIEPLKGYYDVPIATLDF 599
Query: 407 RSLYPSIIITHNVSPDTLNRENCKEY-------DVAPQVGHRFCKDF--PGFIPSLLGNL 457
SLYPSI++ HN+ TL R + + G F K G +P +L NL
Sbjct: 600 SSLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFVKSSVRKGLLPQILENL 659
Query: 458 LEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAW 517
L R++ K + + DP+ +++LD RQ A+K+ ANS YG+ G + C E ++SVT +
Sbjct: 660 LSARKRAKAELAQETDPLRRQVLDGRQLALKVSANSVYGFTGAEVGKLPCLEISQSVTGF 719
Query: 518 GRQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
GRQ I+ ++ +ES+ KV+Y DTD + + E + +++
Sbjct: 720 GRQMIEKTKQLVESKYTLENGYNANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVS 779
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKET 622
S P + LE+E Y ++KK+YA + D ++ +GLE VRRD +
Sbjct: 780 SHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSQPDTHDRMDCKGLEAVRRDNCPLVANL 839
Query: 623 QAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAV 682
L IL + D AV K+V L I +LVI +++TR ++Y HV +
Sbjct: 840 VTSSLRRILVDRDPDGAVAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVEL 899
Query: 683 AKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFDP---KKHK--YDAEYYIEN 735
A+R+ + P G + Y+++ G A ++ DP +H D +YY+
Sbjct: 900 AERMRKRDPGSAPSLGDRVPYVII---GAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLGQ 956
Query: 736 QVLPAVERI 744
Q+ + RI
Sbjct: 957 QLAKPLLRI 965
>gb|AAF49555.1| (AE003529) DNApol-delta gene product [Drosophila melanogaster]
Length = 1092
Score = 218 bits (549), Expect = 2e-55
Identities = 184/610 (30%), Positives = 294/610 (48%), Gaps = 64/610 (10%)
Query: 187 EREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL--PLGRDNS------- 237
E +M+ + +RE DPD++ YN +NFDFPYLL RA L ++ LGR +
Sbjct: 358 ETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKE 417
Query: 238 ---EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHE 294
+ K ++ V +GR+ FDL V+ R L +YTL AV + KE V+ H
Sbjct: 418 QMLQSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVH-HS 476
Query: 295 IAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSSTG 350
I + G + R+A Y ++DA + L ++ + ++AR+ G P+ +
Sbjct: 477 IITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQ 536
Query: 351 NLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-EGIVSLDFRSL 409
V LLRKA + + P+ + E+ YEG V EP++G + + I +LDF SL
Sbjct: 537 IKVLSQLLRKAKTKGFIMPSYTSQGSDEQ-----YEGATVIEPKRGYYADPISTLDFASL 591
Query: 410 YPSIIITHNVSPDTL----------NRENCKEYDVAPQVGHRFCKDFP---GFIPSLLGN 456
YPSI++ HN+ TL +EN ++ V + + G +P +L +
Sbjct: 592 YPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLLPEILES 651
Query: 457 LLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTA 516
LL R++ K +K DP ++K+LD RQ A+KI ANS YG+ G + C E + SVTA
Sbjct: 652 LLAARKRAKNDLKVETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSVTA 711
Query: 517 WGRQYIDLVRRELES-----RGFK----VLYIDTDGLYATIPGAKHEEIKEKALKFVEYI 567
+GR I++ + E+ES G++ V+Y DTD + E E + E +
Sbjct: 712 YGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELV 771
Query: 568 NSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKET 622
+SK ++LE+E Y + KK+YA + D K+ +G+E VRRD S +
Sbjct: 772 SSKFVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANL 831
Query: 623 QAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAV 682
L+ +L + D AV VK+V L I LVI +++ + ++Y A HV +
Sbjct: 832 MNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAK--TDYAAKQAHVEL 889
Query: 683 AKRLAAK--GVKVKPGMVIGYIVLRG--DGPISKRA----IAIEEFDPKKHKYDAEYYIE 734
A ++ + G K G + Y++ + P ++A +E P DA YY+E
Sbjct: 890 AAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLENSVP----IDATYYLE 945
Query: 735 NQVLPAVERI 744
Q+ + RI
Sbjct: 946 QQLSKPLLRI 955
>sp|O50607|DPO1_SULOH DNA POLYMERASE I (DNA POLYMERASE B1) >gi|2696625|dbj|BAA23994.1|
(AB008894) DNA polymerase alpha B1 [Sulfurisphaera
ohwakuensis]
Length = 872
Score = 217 bits (548), Expect = 3e-55
Identities = 223/848 (26%), Positives = 371/848 (43%), Gaps = 144/848 (16%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRT-FRPYIYALLKDDSAIDEVKKITAERHG 60
++ DY + K I +++ KE + + YD T +PY + D ++++ K+ R
Sbjct: 53 LLQVDYDGKKSKAICKLYDKETKKIYILYDNTGHKPYFLTDI-DPEKVNKIPKVV--RDP 109
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
+ V K+ + G I++ K+ ++ P V +R + + +E I + Y
Sbjct: 110 SFDHLETVIKIDP-YSGNKIKLTKIVVKDPLAVRRMRNSVPK------AYEAHIKYFNNY 162
Query: 121 LIDKGLTP-----------------MEGNE------------------------------ 133
+ D GL P ++G E
Sbjct: 163 IYDLGLIPGLPYVVKKGKLEQLRPELKGEEVDEIRKAFADSDEMTKEAVNDWIPIFESEV 222
Query: 134 -ELTFLAVDIETLYH-----EGEEFGKGPIIMISYADEEGAK---VITWKSIDLPY---- 180
++ +A+DIE E + PII IS A +G K V+ + ++
Sbjct: 223 PDVKRVAIDIEVYTPIKGRIPDPEKAEFPIISISLAGNDGTKRVLVLLREDVNSQITKHD 282
Query: 181 --VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI---KLPLGRD 235
VE SERE+I+R +I D +I+T+NGD+FD PY+ RA KL ++P
Sbjct: 283 VIVETFKSERELIRRFFDIIL--DYPIILTFNGDDFDIPYIYYRALKLNFTPEEIPFDII 340
Query: 236 NSEPKMQRMGDSLAVEIKGRIHFDLFPVI-RRTIN-------LPTYTLEAVYEAIFGKSK 287
N E K IH DL+ R I Y L+AV A+ G SK
Sbjct: 341 NDEGKYL-----------AGIHIDLYKFFFNRAIRNYAFEGKYNEYNLDAVATALLGMSK 389
Query: 288 EKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL----GKEFFPMEAQLARLVGQPVWD 343
K+ + + L+++ +Y+ DA++T +L + + LAR+ + +
Sbjct: 390 VKL------DTLISFLDLDKLIEYNSRDAEITLKLTTFNNNLVWKLIILLARISKMGLEE 443
Query: 344 VSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES-------YEGGYVKEPEKG 396
++R+ ++ + RN L P K + +++ + Y+G V +P G
Sbjct: 444 LTRTEVSTWIKNLYYWEHRRRNWLIPLKEEILTRSSQIKTAAIIKGKRYKGAVVIDPPAG 503
Query: 397 LWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCK--EY--DVAPQVGHRFCKDFPGFIPS 452
++ +V LDF SLYPSII N+S +T++ ENCK EY D +V H CKD PG
Sbjct: 504 VFFNVVVLDFASLYPSIIRNWNISYETVDVENCKNKEYVRDETGEVLHYICKDKPGITAV 563
Query: 453 LLGNLLEERQKIKKRMKESKDPVEKK--LLDYRQRAIKILANSYYGYYGYAKARWYCKEC 510
+ G L + R K+ K+ +S++ E++ + D QRA+K+ N+ YG +G Y
Sbjct: 564 ITGLLRDFRVKVYKKKAKSQNISEEQRSVYDVVQRAMKVFINATYGVFGAENFPLYAPAV 623
Query: 511 AESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSK 570
AESVTA GR I S G +VLY DTD ++ P KEK + ++++ K
Sbjct: 624 AESVTAIGRYVITTTVNYCRSIGLQVLYGDTDSMFLWNPS------KEKLEEIIKFVKGK 677
Query: 571 LPGLLELEYEGFYA-RGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEA 629
L+LE + Y F KK Y + +GK +G+ +R+ E K+ +V +
Sbjct: 678 FG--LDLEVDKVYKFVAFSGLKKNYLGVYPDGKTDIKGMLAKKRNTPEFIKKEFNEVKQL 735
Query: 630 ILKHGNVDEAVKI-------VKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGP-HVA 681
+ + D+ KI +KE+ EKL ++L +++PL Y P HV
Sbjct: 736 VTTINSPDDIPKIRDQLEYKIKEIYEKLRHKGYNLDELAFRVMLSKPLESYTKNTPQHVK 795
Query: 682 VAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAV 741
A +L + GV V P +I ++ ++ + +A K + D + YI+ V
Sbjct: 796 AALQLRSYGVMVLPRDIIMFVKVKSKDGVKPVQLA------KLSEIDVDKYID-AVRSTF 848
Query: 742 ERILRAFG 749
E+IL+AFG
Sbjct: 849 EQILKAFG 856
>sp|P28339|DPOD_BOVIN DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|89534|pir||A39299
DNA-directed DNA polymerase (EC 2.7.7.7) delta catalytic
chain - bovine >gi|162974|gb|AAA30493.1| (M80395) DNA
polymerase-delta catalytic-subunit [Bos taurus]
Length = 1106
Score = 217 bits (547), Expect = 4e-55
Identities = 194/709 (27%), Positives = 318/709 (44%), Gaps = 76/709 (10%)
Query: 82 VWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVD 141
+W + HP E + A + + +DI A R KG+ P E +
Sbjct: 290 LWSDVISHPP------EGEWQRIAPLRVLSFDIECAGR----KGIFP-EPERDPVIQICS 338
Query: 142 IETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREK 201
+ + E E F + + + A GAKV +++ E ++++ IR
Sbjct: 339 LGLRWGEPEPFLRLALTLRPCAPILGAKVQSYER-----------EEDLLQAWSTFIRIM 387
Query: 202 DPDVIITYNGDNFDFPYLLKRAEKL------------GIKLPLGRDNSEPKMQRMGDSLA 249
DPDVI YN NFD PYL+ RA+ L G++ + + + + DS
Sbjct: 388 DPDVITGYNIQNFDLPYLISRAQTLKVPGFPLLGRVIGLRSNIRESSFQSRQTGRRDSKV 447
Query: 250 VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGL--ER 307
V + GR+ D+ V+ R L +YTL AV G+ KE V H I + G R
Sbjct: 448 VSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQ-HSIITDLQNGNDQTRRR 506
Query: 308 VAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPV-WDVSRSSTGNLVEWFLLRKAYER 364
+A Y ++DA + L + + ++AR+ G P+ + +SR +V LLR+A +
Sbjct: 507 LAVYCLKDAFLPLRLLERLMVLVNAMEMARVTGVPLGYLLSRGQQVKVVSQ-LLRQAMRQ 565
Query: 365 NELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFRSLYPSIIITHNVSPDT 423
L P E E Y G V EP KG ++ I +LDF SLYPSI++ HN+ T
Sbjct: 566 GLLMPVVKTEGG------EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTT 619
Query: 424 LNRENC-------KEYDVAPQVGHRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDP 474
L R ++ + G F K G +P +L NLL R++ K + + DP
Sbjct: 620 LLRPGAAQKLGLTEDQFIKTPTGDEFVKASVRKGLLPQILENLLSARKRAKAELAKETDP 679
Query: 475 VEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELE---- 530
+ +++LD RQ A+K+ ANS YG+ G R C E ++SVT +GRQ I+ ++ +E
Sbjct: 680 LRRQVLDGRQLALKVSANSVYGFTGAQVGRLPCLEISQSVTGFGRQMIEKTKQLVETKYT 739
Query: 531 -----SRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYAR 585
S KV+Y DTD + + E + ++++ P + LE+E Y
Sbjct: 740 VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFP 799
Query: 586 GFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEA 639
++KK+YA + D ++ +GLE VRRD + L +L + A
Sbjct: 800 YLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPSGA 859
Query: 640 VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKP--GM 697
V ++V L I +LVI +++TR ++Y HV +A+R+ + P G
Sbjct: 860 VAHAQDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVELAERMRKRDPGSAPSLGD 919
Query: 698 VIGYIVLRGDGPISKRAIAIEEFDPKKHK--YDAEYYIENQVLPAVERI 744
+ Y+++ ++ + + +H D +YY+E Q+ + RI
Sbjct: 920 RVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRI 968
>sp|P54358|DPOD_DROME DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|1027513|emb|CAA61369.1|
(X88928) DNA polymerase delta [Drosophila melanogaster]
Length = 1092
Score = 217 bits (546), Expect = 5e-55
Identities = 184/610 (30%), Positives = 293/610 (47%), Gaps = 64/610 (10%)
Query: 187 EREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL--PLGRDNS------- 237
E +M+ + +RE DPD++ YN +NFDFPYLL RA L ++ LGR +
Sbjct: 358 ETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKE 417
Query: 238 ---EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHE 294
+ K ++ V +GR+ FDL V+ R L +YTL AV + KE V+ H
Sbjct: 418 QMLQSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVH-HS 476
Query: 295 IAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSSTG 350
I + G + R A Y ++DA + L ++ + ++AR+ G P+ +
Sbjct: 477 IITDLQNGDEQTRRRSAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQ 536
Query: 351 NLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-EGIVSLDFRSL 409
V LLRKA + + P+ + E+ YEG V EP++G + + I +LDF SL
Sbjct: 537 IKVLSQLLRKAKTKGFIMPSYTSQGSDEQ-----YEGATVIEPKRGYYADPISTLDFASL 591
Query: 410 YPSIIITHNVSPDTL----------NRENCKEYDVAPQVGHRFCKDFP---GFIPSLLGN 456
YPSI++ HN+ TL +EN ++ V + + G +P +L +
Sbjct: 592 YPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLLPEILES 651
Query: 457 LLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTA 516
LL R++ K +K DP ++K+LD RQ A+KI ANS YG+ G + C E + SVTA
Sbjct: 652 LLAARKRAKNDLKVETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSVTA 711
Query: 517 WGRQYIDLVRRELES-----RGFK----VLYIDTDGLYATIPGAKHEEIKEKALKFVEYI 567
+GR I++ + E+ES G++ V+Y DTD + E E + E +
Sbjct: 712 YGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELV 771
Query: 568 NSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKET 622
+SK ++LE+E Y + KK+YA + D K+ +G+E VRRD S +
Sbjct: 772 SSKFVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANL 831
Query: 623 QAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAV 682
L+ +L + D AV VK+V L I LVI +++ + ++Y A HV +
Sbjct: 832 MNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAK--TDYAAKQAHVEL 889
Query: 683 AKRLAAK--GVKVKPGMVIGYIVLRG--DGPISKRA----IAIEEFDPKKHKYDAEYYIE 734
A ++ + G K G + Y++ + P ++A +E P DA YY+E
Sbjct: 890 AAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLENSVP----IDATYYLE 945
Query: 735 NQVLPAVERI 744
Q+ + RI
Sbjct: 946 QQLSKPLLRI 955
>emb|CAA43922.1| (X61920) DNA polymerase III catalytic subunit [Saccharomyces
cerevisiae]
Length = 1097
Score = 216 bits (545), Expect = 6e-55
Identities = 175/595 (29%), Positives = 279/595 (46%), Gaps = 51/595 (8%)
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI------------KLPL 232
++E EM+ I + DPDVII YN NFD PYLL RA+ L + K +
Sbjct: 377 ATEEEMLSNWRNFIIKVDPDVIIGYNTTNFDIPYLLNRAKALKVNDFPYFGRLKTVKQEI 436
Query: 233 GRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
K ++ V I GR+ DL I+R L +YTL AV G+ KE V+
Sbjct: 437 KESVFSSKAYGTRETKNVNIDGRLQLDLLQFIQREYKLRSYTLNAVSAHFLGEQKEDVHY 496
Query: 293 HEIAEAWE-TGKGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSST 349
I++ + R+A Y ++DA + L ++ + ++AR+ G P +
Sbjct: 497 SIISDLQNGDSETRRRLAVYCLKDAYLPLRLMEKLMALVNYTEMARVTGVPFSYLLARGQ 556
Query: 350 GNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFRS 408
V L RK E + + PN + ++ YEG V EP +G ++ I +LDF S
Sbjct: 557 QIKVVSQLFRKCLEIDTVIPNMQSQASDDQ-----YEGATVIEPIRGYYDVPIATLDFNS 611
Query: 409 LYPSIIITHNVSPDTL------NRENCK---EYDVAPQVGHRFC--KDFPGFIPSLLGNL 457
LYPSI++ HN+ TL R N K +Y + P G F K G +P +L L
Sbjct: 612 LYPSIMMAHNLCYTTLCNKATVERLNLKIDEDYVITPN-GDYFVTTKRRRGILPIILDEL 670
Query: 458 LEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAW 517
+ R++ KK +++ KDP ++ +L+ RQ A+KI ANS YG+ G + C + SVTA+
Sbjct: 671 ISARKRAKKDLRDEKDPFKRDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVTAY 730
Query: 518 GRQYIDLVRRELESR-----GFK----VLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
GR I + ++ + G+K V+Y DTD + +E + + +Y++
Sbjct: 731 GRTMILKTKTAVQEKYCIKNGYKHDAVVVYGDTDSVMVKFGTTDLKEAMDLGTEAAKYVS 790
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKETQ 623
+ + LE+E Y + KK+YA + D+ K+ +GL VRRD +
Sbjct: 791 TLFKHPINLEFEKAYFPYLLINKKRYAGLFWTNPDKFDKLDQKGLASVRRDSCSLVSIVM 850
Query: 624 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVA 683
KVL+ IL NVD A+ V+E + + KL+I + + Y PH +A
Sbjct: 851 NKVLKKILIERNVDGALAFVRETINDILHNRVDISKLIISKTLA---PNYTNPQPHAVLA 907
Query: 684 KRLAAK-GVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
+R+ + GV G + Y+++ G+ + RA + D+ YY+ NQ+
Sbjct: 908 ERMKRREGVGPNVGDRVDYVIIGGNDKLYNRAEDPLFVLENNIQVDSRYYLTNQL 962
>gi|6320101 largest and catalytic subunit of DNA polymerase III (delta); Cdc2p
[Saccharomyces cerevisiae]
>gi|1706506|sp|P15436|DPOD_YEAST DNA POLYMERASE DELTA
LARGE CHAIN (DNA POLYMERASE III) >gi|2144435|pir||RNBYL3
DNA-directed DNA polymerase (EC 2.7.7.7) III large chain
- yeast (Saccharomyces cerevisiae)
>gi|1199547|emb|CAA64911.1| (X95644) ORF 2366
[Saccharomyces cerevisiae] >gi|1431142|emb|CAA98669.1|
(Z74150) ORF YDL102w [Saccharomyces cerevisiae]
Length = 1097
Score = 216 bits (545), Expect = 6e-55
Identities = 175/595 (29%), Positives = 279/595 (46%), Gaps = 51/595 (8%)
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI------------KLPL 232
++E EM+ I + DPDVII YN NFD PYLL RA+ L + K +
Sbjct: 377 ATEEEMLSNWRNFIIKVDPDVIIGYNTTNFDIPYLLNRAKALKVNDFPYFGRLKTVKQEI 436
Query: 233 GRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
K ++ V I GR+ DL I+R L +YTL AV G+ KE V+
Sbjct: 437 KESVFSSKAYGTRETKNVNIDGRLQLDLLQFIQREYKLRSYTLNAVSAHFLGEQKEDVHY 496
Query: 293 HEIAEAWE-TGKGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSST 349
I++ + R+A Y ++DA + L ++ + ++AR+ G P +
Sbjct: 497 SIISDLQNGDSETRRRLAVYCLKDAYLPLRLMEKLMALVNYTEMARVTGVPFSYLLARGQ 556
Query: 350 GNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFRS 408
V L RK E + + PN + ++ YEG V EP +G ++ I +LDF S
Sbjct: 557 QIKVVSQLFRKCLEIDTVIPNMQSQASDDQ-----YEGATVIEPIRGYYDVPIATLDFNS 611
Query: 409 LYPSIIITHNVSPDTL------NRENCK---EYDVAPQVGHRFC--KDFPGFIPSLLGNL 457
LYPSI++ HN+ TL R N K +Y + P G F K G +P +L L
Sbjct: 612 LYPSIMMAHNLCYTTLCNKATVERLNLKIDEDYVITPN-GDYFVTTKRRRGILPIILDEL 670
Query: 458 LEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAW 517
+ R++ KK +++ KDP ++ +L+ RQ A+KI ANS YG+ G + C + SVTA+
Sbjct: 671 ISARKRAKKDLRDEKDPFKRDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVTAY 730
Query: 518 GRQYIDLVRRELESR-----GFK----VLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
GR I + ++ + G+K V+Y DTD + +E + + +Y++
Sbjct: 731 GRTMILKTKTAVQEKYCIKNGYKHDAVVVYGDTDSVMVKFGTTDLKEAMDLGTEAAKYVS 790
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKETQ 623
+ + LE+E Y + KK+YA + D+ K+ +GL VRRD +
Sbjct: 791 TLFKHPINLEFEKAYFPYLLINKKRYAGLFWTNPDKFDKLDQKGLASVRRDSCSLVSIVM 850
Query: 624 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVA 683
KVL+ IL NVD A+ V+E + + KL+I + + Y PH +A
Sbjct: 851 NKVLKKILIERNVDGALAFVRETINDILHNRVDISKLIISKTLA---PNYTNPQPHAVLA 907
Query: 684 KRLAAK-GVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
+R+ + GV G + Y+++ G+ + RA + D+ YY+ NQ+
Sbjct: 908 ERMKRREGVGPNVGDRVDYVIIGGNDKLYNRAEDPLFVLENNIQVDSRYYLTNQL 962
>gb|AAB47255.1| (U83705) DNA polymerase delta' [Mesocricetus auratus]
Length = 1102
Score = 216 bits (544), Expect = 8e-55
Identities = 208/729 (28%), Positives = 331/729 (44%), Gaps = 85/729 (11%)
Query: 68 VEKVQKKFLGRPIEV---WKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDK 124
V + +KK +EV W + HP E + A + + +DI A R K
Sbjct: 269 VWRTEKKATQCQLEVDVLWSDVISHPP------EGQWQRIAPLRVLSFDIECAGR----K 318
Query: 125 GLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVV 184
G+ P E + + + E E F + + + A GAKV +++
Sbjct: 319 GIFP-EPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYER--------- 368
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI-KLP-LGR-------- 234
E ++++ I D DVI YN NFD PYL+ RA+ L + + P LGR
Sbjct: 369 --EEDLLQAWPNFILAMDSDVITGYNIQNFDLPYLISRAQTLKVDRFPFLGRVTGLRSNI 426
Query: 235 DNSEPKMQRMG--DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
+S + +++G DS V + GR+ D+ V+ R L +YTL AV G+ KE V
Sbjct: 427 RDSSFQSRQVGRRDSKVVSMVGRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQ- 485
Query: 293 HEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPV-WDVSRS 347
H I + G + R+A Y + DA + L + + ++AR+ G P+ + +SR
Sbjct: 486 HSIITDLQNGNEQTRRRLAVYCLRDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRG 545
Query: 348 STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDF 406
+V LLR+A + L P E E Y G V EP KG ++ I +LDF
Sbjct: 546 QQVKVVSQ-LLRQAMRQGLLMPVVKTEGG------EDYTGATVIEPLKGYYDVPIATLDF 598
Query: 407 RSLYPSIIITHNVSPDTLNRENCKEY-------DVAPQVGHRFCKDF--PGFIPSLLGNL 457
SLYPSI++ HN+ TL R + + G F K G +P +L NL
Sbjct: 599 SSLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFVKSSVRKGLLPQILENL 658
Query: 458 LEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAW 517
L R++ K + + DP+ +++LD RQ A+K+ ANS YG+ G + C E ++SVT +
Sbjct: 659 LSARKRAKAELAQETDPLRRQVLDGRQLALKVSANSVYGFTGAEVGKLPCLEISQSVTGF 718
Query: 518 GRQYIDLVRRELESR---------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
GRQ I+ ++ +ES+ KV+Y DTD + + E + +++
Sbjct: 719 GRQMIEKTKQLVESKYTLENGYNANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVS 778
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYALI------DEEGKIVTRGLEIVRRDWSEIAKET 622
S P + LE+E Y ++KK+YA + D ++ +GLE VRRD +
Sbjct: 779 SHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSQPDTHDRMDCKGLEAVRRDNCPLVANL 838
Query: 623 QAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAV 682
L IL + D AV K+V L I +LVI +++TR ++Y HV +
Sbjct: 839 VTSSLRRILVDRDPDGAVAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVEL 898
Query: 683 AKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFDP---KKHK--YDAEYYIEN 735
A+R+ + P G + Y+++ G A ++ DP +H D +YY+
Sbjct: 899 AERMRKRDPGSAPSLGDRVPYVII---GAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLGQ 955
Query: 736 QVLPAVERI 744
Q+ + RI
Sbjct: 956 QLAKPLLRI 964
>emb|CAA33504.1| (X15477) DNA polymerase III large subunit (AA 1 - 1093)
[Saccharomyces cerevisiae]
Length = 1093
Score = 214 bits (540), Expect = 2e-54
Identities = 175/605 (28%), Positives = 280/605 (45%), Gaps = 48/605 (7%)
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI------------KLPL 232
++E EM+ I + DPDVII YN NFD PYLL RA+ L + K +
Sbjct: 375 ATEEEMLSNWRNFIIKVDPDVIIGYNTTNFDIPYLLNRAKALKVNDFPYFGRLKTVKQEI 434
Query: 233 GRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
K ++ V I GR+ DL I+R L +YTL AV G+ KE V+
Sbjct: 435 KESVFSSKAYGTRETKNVNIDGRLQLDLLQFIQREYKLRSYTLNAVSAHFLGEQKEDVHY 494
Query: 293 HEIAEAWE-TGKGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSST 349
I++ + R+A Y ++DA + L ++ + ++AR+ G P +
Sbjct: 495 SIISDLQNGDSETRRRLAVYCLKDAYLPLRLMEKLMALVNYTEMARVTGVPFSYLLARGQ 554
Query: 350 GNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE-GIVSLDFRS 408
V L RK E + + PN + ++ YEG V EP +G ++ I +LDF S
Sbjct: 555 QIKVVSQLFRKCLEIDTVIPNMQSQASDDQ-----YEGATVIEPIRGYYDVPIATLDFNS 609
Query: 409 LYPSIIITHNVSPDTL------NRENCK-EYDVAPQVGHRFC--KDFPGFIPSLLGNLLE 459
LYPSI++ HN+ TL R N K + D G F K G +P +L L+
Sbjct: 610 LYPSIMMAHNLCYTTLCNKATVERLNLKIDEDYVIHYGDYFVTTKRRRGILPIILDELIS 669
Query: 460 ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR 519
R++ KK +++ KDP ++ +L+ RQ A+KI ANS YG+ G + C + SVTA+GR
Sbjct: 670 ARKRAKKDLRDEKDPFKRDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVTAYGR 729
Query: 520 QYIDLVRRELESR-----GFK----VLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSK 570
I + ++ + G+K V+Y DTD + +E + + +Y+++
Sbjct: 730 TMILKTKTAVQEKYCIKNGYKHDAVVVYGDTDSVMVKFGTTDLKEAMDLGTEAAKYVSTL 789
Query: 571 LPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKETQAK 625
+ LE+E Y + KK+YA + D+ K+ +GL VRRD + K
Sbjct: 790 FKHPINLEFEKAYFPYLLINKKRYAGLFWTNPDKFDKLDQKGLASVRRDSCSLVSIVMNK 849
Query: 626 VLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKR 685
VL+ IL NVD A+ +E + + KL+I + + Y PH +A+R
Sbjct: 850 VLKKILIERNVDGALAFDRETINDILHNRVDISKLIISKTLA---PNYTNPQPHAVLAER 906
Query: 686 LAAK-GVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERI 744
+ + GV G + Y+++ G+ + RA + D+ YY+ NQ+ + I
Sbjct: 907 MKRREGVGPNVGDRVDYVIIGGNDKLYNRAEDPLFVLENNIQVDSRYYLTNQLQNPIISI 966
Query: 745 LRAFG 749
+ G
Sbjct: 967 VAPIG 971
>sp|P26811|DPO1_SULSO DNA POLYMERASE I >gi|99266|pir||S23019 DNA-directed DNA polymerase
(EC 2.7.7.7) - Sulfolobus solfataricus
>gi|47565|emb|CAA45795.1| (X64466) DNA-directed DNA
polymerase [Sulfolobus solfataricus]
Length = 882
Score = 214 bits (539), Expect = 3e-54
Identities = 226/852 (26%), Positives = 370/852 (42%), Gaps = 138/852 (16%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRT-FRPYIYALLKDDSAIDEVKKITAERHG 60
++ DY + GK + ++F KE + YD T +PY L+ D + ++ KI R
Sbjct: 53 LLQVDYDGKKGKAVCKLFDKETQKIYALYDNTGHKPYFLVDLEPDK-VGKIPKIV--RDP 109
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
I V K+ + ++ K+ + P V +R + + +E I + Y
Sbjct: 110 SFDHIETVSKIDP-YTWNKFKLTKIVVRDPHAVRRLRNDVPK------AYEAHIKYFNNY 162
Query: 121 LIDKGLTP------MEGNEELTFLAVD------IETLYHEGEEFGKG------------- 155
+ D GL P G E +L++D I+ + + +E +
Sbjct: 163 MYDIGLIPGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEI 222
Query: 156 ----------------------------PIIMISYADEEGAKVITWKS----------ID 177
PII I+ A +G K + + +D
Sbjct: 223 PKIKRVAIDIEVYTPVKGRIPDSQKAEFPIISIALAGSDGLKKVLVLNRNDVNEGSVKLD 282
Query: 178 LPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNS 237
VE ++E E++ R ++ E +++T+NGD+FD PY+ RA KLG P
Sbjct: 283 GISVERFNTEYELLGRFFDILLEYP--IVLTFNGDDFDLPYIYFRALKLGY-FP-----E 334
Query: 238 EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTI--------NLPTYTLEAVYEAIFGKSKEK 289
E + G A + G +H DL+ Y L+AV +A+ G SK K
Sbjct: 335 EIPIDVAGKDEAKYLAG-LHIDLYKFFFNKAVRNYAFEGKYNEYNLDAVAKALLGTSKVK 393
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQL----ARLVGQPVWDVS 345
V + + +E++ +Y+ DA++T +L + +L +R+ + +++
Sbjct: 394 V------DTLISFLDVEKLIEYNFRDAEITLQLTTFNNDLTMKLIVLFSRISRLGIEELT 447
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES-------YEGGYVKEPEKGLW 398
R+ V+ + +RN L P K + +R S Y+G V +P G++
Sbjct: 448 RTEISTWVKNLYYWEHRKRNWLIPLKEEILAKSSNIRTSALIKGKGYKGAVVIDPPAGIF 507
Query: 399 EGIVSLDFRSLYPSIIITHNVSPDTLNRENCKE-YDVAPQVG---HRFCKDFPGFIPSLL 454
I LDF SLYPSII T N+S +T++ + CK+ Y+V + G H C D PG +
Sbjct: 508 FNITVLDFASLYPSIIRTWNLSYETVDIQQCKKPYEVKDETGEVLHIVCMDRPGITAVIT 567
Query: 455 GNLLEERQKI-KKRMKESKDPVEKKLL-DYRQRAIKILANSYYGYYGYAKARWYCKECAE 512
G L + R KI KK+ K + E+KLL D QRA+K+ N+ YG +G Y AE
Sbjct: 568 GLLRDFRVKIYKKKAKNPNNSEEQKLLYDVVQRAMKVFINATYGVFGAETFPLYAPRVAE 627
Query: 513 SVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLP 572
SVTA GR I ++ G VLY DTD L+ P + E +K+V K
Sbjct: 628 SVTALGRYVITSTVKKAREEGLTVLYGDTDSLFLLNP---PKNSLENIIKWV-----KTT 679
Query: 573 GLLELEYEGFYA-RGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAIL 631
L+LE + Y F KK Y + ++GK+ +G+ + +R+ E K+ +V E ++
Sbjct: 680 FNLDLEVDKTYKFVAFSGLKKNYFGVYQDGKVDIKGMLVKKRNTPEFVKKVFNEVKELMI 739
Query: 632 KHGNVDEA-------VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGP-HVAVA 683
+ ++ V +VK EKL ++L +++PL YK P HV A
Sbjct: 740 SINSPNDVKEIKRKIVDVVKGSYEKLKNKGYNLDELAFKVMLSKPLDAYKKNTPQHVKAA 799
Query: 684 KRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVER 743
+L GV V P +I Y+ +R + +A K + DAE Y+E + E+
Sbjct: 800 LQLRPFGVNVLPRDIIYYVKVRSKDGVKPVQLA------KVTEIDAEKYLE-ALRSTFEQ 852
Query: 744 ILRAFGYRKEDL 755
ILRAFG +++
Sbjct: 853 ILRAFGVSWDEI 864
>gb|AAK40869.1| DNA polymerase I (DNA polymerase B1) (dpo1) [Sulfolobus
solfataricus]
Length = 882
Score = 213 bits (536), Expect = 7e-54
Identities = 226/852 (26%), Positives = 370/852 (42%), Gaps = 138/852 (16%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRT-FRPYIYALLKDDSAIDEVKKITAERHG 60
++ DY + GK + ++F KE + YD T +PY L+ D + ++ KI R
Sbjct: 53 LLQVDYDGKKGKAVCKLFDKETQKIYALYDNTGHKPYFLVDLEPDK-VGKIPKIV--RDP 109
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
I V K+ + ++ K+ + P V +R + + +E I + Y
Sbjct: 110 SFDHIETVSKIDP-YTWNKFKLTKIVVRDPLAVRRLRNDVPK------AYEAHIKYFNNY 162
Query: 121 LIDKGLTP------MEGNEELTFLAVD------IETLYHEGEEFGKG------------- 155
+ D GL P G E +L++D I+ + + +E +
Sbjct: 163 MYDIGLIPGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEI 222
Query: 156 ----------------------------PIIMISYADEEGAKVITWKS----------ID 177
PII I+ A +G K + + +D
Sbjct: 223 PKIKRVAIDIEVYTPVKGRIPDSQKAEFPIISIALAGSDGLKKVLVLNRNDVNEGSVKLD 282
Query: 178 LPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNS 237
VE ++E E++ R ++ E +++T+NGD+FD PY+ RA KLG P
Sbjct: 283 GISVERFNTEYELLGRFFDILLEYP--IVLTFNGDDFDLPYIYFRALKLGY-FP-----E 334
Query: 238 EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTI--------NLPTYTLEAVYEAIFGKSKEK 289
E + G A + G +H DL+ Y L+AV +A+ G SK K
Sbjct: 335 EIPIDVAGKDEAKYLAG-LHIDLYKFFFNKAVRNYAFEGKYNEYNLDAVAKALLGTSKVK 393
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQL----ARLVGQPVWDVS 345
V + + +E++ +Y+ DA++T +L + +L +R+ + +++
Sbjct: 394 V------DTLISFLDVEKLIEYNFRDAEITLQLTTFNNDLTMKLIVLFSRISRLGIEELT 447
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES-------YEGGYVKEPEKGLW 398
R+ V+ + +RN L P K + +R S Y+G V +P G++
Sbjct: 448 RTEISTWVKNLYYWEHRKRNWLIPLKEEILAKSSNIRTSALIKGKGYKGAVVIDPPAGIF 507
Query: 399 EGIVSLDFRSLYPSIIITHNVSPDTLNRENCKE-YDVAPQVG---HRFCKDFPGFIPSLL 454
I LDF SLYPSII T N+S +T++ + CK+ Y+V + G H C D PG +
Sbjct: 508 FNITVLDFASLYPSIIRTWNLSYETVDIQQCKKPYEVKDETGEVLHIVCMDRPGITAVIT 567
Query: 455 GNLLEERQKI-KKRMKESKDPVEKKLL-DYRQRAIKILANSYYGYYGYAKARWYCKECAE 512
G L + R KI KK+ K + E+KLL D QRA+K+ N+ YG +G Y AE
Sbjct: 568 GLLRDFRVKIYKKKAKNPNNSEEQKLLYDVVQRAMKVFINATYGVFGAETFPLYAPAVAE 627
Query: 513 SVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLP 572
SVTA GR I ++ G VLY DTD L+ P + E +K+V K
Sbjct: 628 SVTALGRYVITSTVKKAREEGLTVLYGDTDSLFLLNP---PKNSLENIIKWV-----KTT 679
Query: 573 GLLELEYEGFYA-RGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAIL 631
L+LE + Y F KK Y + ++GK+ +G+ + +R+ E K+ +V E ++
Sbjct: 680 FNLDLEVDKTYKFVAFSGLKKNYFGVYQDGKVDIKGMLVKKRNTPEFVKKVFNEVKELMI 739
Query: 632 KHGNVDEA-------VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGP-HVAVA 683
+ ++ V +VK EKL ++L +++PL YK P HV A
Sbjct: 740 SINSPNDVKEIKRKIVDVVKGSYEKLKNKGYNLDELAFKVMLSKPLDAYKKNTPQHVKAA 799
Query: 684 KRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVER 743
+L GV V P +I Y+ +R + +A K + DAE Y+E + E+
Sbjct: 800 LQLRPFGVNVLPRDIIYYVKVRSKDGVKPVQLA------KVTEIDAEKYLE-ALRSTFEQ 852
Query: 744 ILRAFGYRKEDL 755
ILRAFG +++
Sbjct: 853 ILRAFGVSWDEI 864
>gb|AAB53090.1| (U92875) DNA polymerase [Sulfolobus solfataricus]
>gi|6015920|emb|CAB57747.1| (Y18930) DNA polymerase I
[Sulfolobus solfataricus]
Length = 882
Score = 213 bits (536), Expect = 7e-54
Identities = 226/852 (26%), Positives = 370/852 (42%), Gaps = 138/852 (16%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRT-FRPYIYALLKDDSAIDEVKKITAERHG 60
++ DY + GK + ++F KE + YD T +PY L+ D + ++ KI R
Sbjct: 53 LLQVDYDGKKGKAVCKLFDKETQKIYALYDNTGHKPYFLVDLEPDK-VGKIPKIV--RDP 109
Query: 61 KIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRY 120
I V K+ + ++ K+ + P V +R + + +E I + Y
Sbjct: 110 SFDHIETVSKIDP-YTWNKFKLTKIVVRDPLAVRRLRNDVPK------AYEAHIKYFNNY 162
Query: 121 LIDKGLTP------MEGNEELTFLAVD------IETLYHEGEEFGKG------------- 155
+ D GL P G E +L++D I+ + + +E +
Sbjct: 163 MYDIGLIPGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEI 222
Query: 156 ----------------------------PIIMISYADEEGAKVITWKS----------ID 177
PII I+ A +G K + + +D
Sbjct: 223 PKIKRVAIDIEVYTPVKGRIPDSQKAEFPIISIALAGSDGLKKVLVLNRNDVNEGSVKLD 282
Query: 178 LPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNS 237
VE ++E E++ R ++ E +++T+NGD+FD PY+ RA KLG P
Sbjct: 283 GISVERFNTEYELLGRFFDILLEYP--IVLTFNGDDFDLPYIYFRALKLGY-FP-----E 334
Query: 238 EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTI--------NLPTYTLEAVYEAIFGKSKEK 289
E + G A + G +H DL+ Y L+AV +A+ G SK K
Sbjct: 335 EIPIDVAGKDEAKYLAG-LHIDLYKFFFNKAVRNYAFEGKYNEYNLDAVAKALLGTSKVK 393
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQL----ARLVGQPVWDVS 345
V + + +E++ +Y+ DA++T +L + +L +R+ + +++
Sbjct: 394 V------DTLISFLDVEKLIEYNFRDAEITLQLTTFNNDLTMKLIVLFSRISRLGIEELT 447
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES-------YEGGYVKEPEKGLW 398
R+ V+ + +RN L P K + +R S Y+G V +P G++
Sbjct: 448 RTEISTWVKNLYYWEHRKRNWLIPLKEEILAKSSNIRTSALIKGKGYKGAVVIDPPAGIF 507
Query: 399 EGIVSLDFRSLYPSIIITHNVSPDTLNRENCKE-YDVAPQVG---HRFCKDFPGFIPSLL 454
I LDF SLYPSII T N+S +T++ + CK+ Y+V + G H C D PG +
Sbjct: 508 FNITVLDFASLYPSIIRTWNLSYETVDIQQCKKPYEVKDETGEVLHIVCMDRPGITAVIT 567
Query: 455 GNLLEERQKI-KKRMKESKDPVEKKLL-DYRQRAIKILANSYYGYYGYAKARWYCKECAE 512
G L + R KI KK+ K + E+KLL D QRA+K+ N+ YG +G Y AE
Sbjct: 568 GLLRDFRVKIYKKKAKNPNNSEEQKLLYDVVQRAMKVFINATYGVFGAETFPLYAPAVAE 627
Query: 513 SVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLP 572
SVTA GR I ++ G VLY DTD L+ P + E +K+V K
Sbjct: 628 SVTALGRYVITSTVKKAREEGLTVLYGDTDSLFLLNP---PKNSLENIIKWV-----KTT 679
Query: 573 GLLELEYEGFYA-RGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAIL 631
L+LE + Y F KK Y + ++GK+ +G+ + +R+ E K+ +V E ++
Sbjct: 680 FNLDLEVDKTYKFVAFSGLKKNYFGVYQDGKVDIKGMLVKKRNTPEFVKKVFNEVKELMI 739
Query: 632 KHGNVDEA-------VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGP-HVAVA 683
+ ++ V +VK EKL ++L +++PL YK P HV A
Sbjct: 740 SINSPNDVKEIKRKIVDVVKGSYEKLKNKGYNLDELAFKVMLSKPLDAYKKNTPQHVKAA 799
Query: 684 KRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVER 743
+L GV V P +I Y+ +R + +A K + DAE Y+E + E+
Sbjct: 800 LQLRPFGVNVLPRDIIYYVKVRSKDGVKPVQLA------KVTEIDAEKYLE-ALRSTFEQ 852
Query: 744 ILRAFGYRKEDL 755
ILRAFG +++
Sbjct: 853 ILRAFGVSWDEI 864
>pir||E69125 DNA-dependent DNA polymerase family B (PolB2) - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621253|gb|AAB84714.1| (AE000807) DNA-dependent DNA
polymerase family B (PolB2) [Methanobacterium
thermoautotrophicum]
Length = 223
Score = 210 bits (529), Expect = 5e-53
Identities = 105/202 (51%), Positives = 150/202 (73%), Gaps = 3/202 (1%)
Query: 554 EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRR 613
+EI + +F+++INS LP +ELE+EGFY RGFFVTKK+YALI+++ IV +GLE+VRR
Sbjct: 9 DEILSQVKRFLKHINSNLPEGMELEFEGFYRRGFFVTKKRYALIEDD-TIVAKGLELVRR 67
Query: 614 DWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEY 673
DW+ IAK+TQ KVL AIL+ G+ ++A +I++EV ++ + ++ + LVI+ QITR LSEY
Sbjct: 68 DWAPIAKKTQRKVLMAILRDGSPEKAREIIREVVGRIRRGDVELDDLVIHTQITRDLSEY 127
Query: 674 KAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYI 733
K IGPHV AKR KG +V+ G ++ YI+++G GPIS+RA +E D + YD +YYI
Sbjct: 128 KQIGPHVIAAKRSLEKGRRVERGSIVRYIIVKGRGPISQRAFPVE--DAEGMGYDPDYYI 185
Query: 734 ENQVLPAVERILRAFGYRKEDL 755
ENQV+ AV RI+ + GY ED+
Sbjct: 186 ENQVMAAVSRIMSSLGYSTEDM 207
>gb|AAG19049.1| (AE005004) DNA polymerase B1; PolB1 [Halobacterium sp. NRC-1]
Length = 901
Score = 208 bits (525), Expect = 1e-52
Identities = 206/771 (26%), Positives = 343/771 (43%), Gaps = 127/771 (16%)
Query: 1 MIIDADYITEDG----KPIIRIFKKEKGEFKVEYDRT--FRPYIYA---LLKDDSAIDEV 51
M+ DY E +P++ +F + + + E+ R FRPY YA L +D D+V
Sbjct: 60 MVTQVDYTIEGSGDRERPVLHVFGRTTDD-EAEHVRVHGFRPYFYAPTATLSEDDLTDDV 118
Query: 52 KKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFE 111
IT E + G + K++ P+DV IR+ D +E
Sbjct: 119 -------------ITGTEDGYESIRGEALT--KIFGRTPRDVGNIRDAF-------DHYE 156
Query: 112 YDIPFAKRYLIDKGLTP-----------------------MEGNEELTFLAVDIETLYHE 148
DI F R LIDK +T E +L DIE
Sbjct: 157 ADILFPNRLLIDKDITDGVRVPARRADDGALYVHHDEIAACEVAADLRVNTFDIEVNDRN 216
Query: 149 G-EEFGKGPIIMISYADEEGAKVITW------KSIDLPY---------------VEVVSS 186
G E G+ P++ ++ D + + W ++D P V V +
Sbjct: 217 GFPEDGEEPVVCLTSHDSYRDEYVAWLYAAPDATVDAPTAVPGYDPLTDDADIDVRVFDT 276
Query: 187 EREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGD 246
E M + I + +PDV+ +N D+FD PYL+ R ++L + D ++ R+ +
Sbjct: 277 EEAMHDAFLSYIEDTNPDVLTGWNFDDFDAPYLIDRLDELDPRTD--HDLDSDRLSRVSE 334
Query: 247 SLAV-----EIKGRIHFDLFPVIRRT--INLPTYTLEAVYEAIFGKSKEKVYAHEIAEAW 299
+KGR+ FDL +RT L +Y L+AV E G KE+ Y +I + W
Sbjct: 335 VWTSGWGGPNVKGRVVFDLLYAYQRTKYSELDSYRLDAVGEQELGVGKER-YPGDIGDLW 393
Query: 300 ETGKGLERVAKYSMEDAKVTFELGKE--FFPMEAQLARLVGQPVWDVSRSSTGNLVEWFL 357
E ER+ +Y++ D ++ E+ ++ + +LVG + D + + G+ V+ ++
Sbjct: 394 EDDP--ERLLEYNLRDVELCVEIDRKQSIVAFWDEARKLVGCKLEDAT--TPGDAVDMYV 449
Query: 358 LRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITH 417
L KA+ N + P+K + E +EGG V +P G+ E + LD +SLYP ++T
Sbjct: 450 LHKAFG-NFVLPSKGQQDA------EEFEGGAVFDPITGVRENVSVLDLKSLYPMSMVTI 502
Query: 418 NVSPDTLNRENCKEYD---VAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESK-D 473
N SP+T + + +E+D G F K+ G I ++ LL ER++ K R + + D
Sbjct: 503 NASPET--KVDPEEFDGDTYRTPTGVHFRKEPDGIIREMVDELLTEREEKKARRDDHEPD 560
Query: 474 PVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRG 533
+ + D +Q A+K++ NS YG +G+ + R Y + + VT+ R+ ID + E G
Sbjct: 561 SEDYERYDRQQAAVKVIMNSLYGVFGWDRFRLYDRAMSAGVTSTNREVIDFTEQAAEEFG 620
Query: 534 FKVLYIDTDGLYATIPG--AKHEEIKEKALKFVEYINSKLPGL-----------LELEYE 580
++V Y DTD + + K E I E + ++IN+ ++E+E
Sbjct: 621 YEVAYGDTDSVMLELGDDMTKAEAIAE-SFDIEDHINAAYDEFAREQLHADDHRFQIEFE 679
Query: 581 GFYARGFFVTKKK-YA--LIDEEGKIV----TRGLEIVRRDWSEIAKETQAKVLEAILKH 633
Y R F KKK YA ++ +EGK V G E R D + I K Q +V++ +++
Sbjct: 680 KLYRRFFQAGKKKRYAGHIVWKEGKDVDDVDITGFEYQRSDIAPITKRVQKEVIDLVVRE 739
Query: 634 GNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAK 684
G+VD + V V E+ + + + + I I + L Y+ V AK
Sbjct: 740 GDVDAVEEYVHGVIEEFQEGDADLDDIGIPGGIGKRLDNYETDTAQVRGAK 790
>sp|P30316|DPOD_SCHPO DNA POLYMERASE DELTA LARGE CHAIN (DNA POLYMERASE III)
>gi|101026|pir||S19661 DNA-directed DNA polymerase (EC
2.7.7.7) III large chain - fission yeast
(Schizosaccharomyces pombe) >gi|5011|emb|CAA41968.1|
(X59278) catalytic subunit DNA polymerase delta
[Schizosaccharomyces pombe]
Length = 1084
Score = 206 bits (518), Expect = 9e-52
Identities = 197/688 (28%), Positives = 310/688 (44%), Gaps = 77/688 (11%)
Query: 105 AVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYAD 164
A + I +DI A R KG+ P + + +A I T Y + F + + + +
Sbjct: 292 APLRIMSFDIECAGR----KGVFPDPSIDPVIQIA-SIVTQYGDSTPFVRNVFCVDTCSQ 346
Query: 165 EEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE 224
G +V +++ + EM+ K +R+ DPDV+I YN NFD PYLL RA+
Sbjct: 347 IVGTQVYEFQN-----------QAEMLSSWSKFVRDVDPDVLIGYNICNFDIPYLLDRAK 395
Query: 225 KLGI-KLPL-GRDNS----------EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPT 272
L I PL GR ++ K +S I GR+ D+ V++R L +
Sbjct: 396 SLRIHNFPLLGRIHNFFSVAKETSFSSKAYGTRESKTTSIPGRLQLDMLQVMQRDFKLRS 455
Query: 273 YTLEAVYEAIFGKSKEKVYAHEIAEAWE-TGKGLERVAKYSMEDAKVTFELGKEF--FPM 329
Y+L AV G+ KE V+ I + T R+A Y ++DA + L + F
Sbjct: 456 YSLNAVCSQFLGEQKEDVHYSIITDLQNGTADSRRRLAIYCLKDAYLPQRLMDKLMCFVN 515
Query: 330 EAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGY 389
++AR+ G P + V L KA + + + PN E YEG
Sbjct: 516 YTEMARVTGVPFNFLLARGQQIKVISQLFCKALQHDLVVPNIR-----VNGTDEQYEGAT 570
Query: 390 VKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKE---------YDVAPQVG 439
V EP KG ++ I +LDF SLYPSI+ HN+ TL N E Y V P G
Sbjct: 571 VIEPIKGYYDTPIATLDFSSLYPSIMQAHNLCYTTLLDSNTAELLKLKQDVDYSVTPN-G 629
Query: 440 HRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGY 497
F K G +P +L +LL R+K K +K+ DP +K +LD RQ A+K+ ANS YG+
Sbjct: 630 DYFVKPHVRKGLLPIILADLLNARKKAKADLKKETDPFKKAVLDGRQLALKVSANSVYGF 689
Query: 498 YGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-----GFK----VLYIDTDGLYATI 548
G R C + SVT++GRQ I+ + +E R G+ V+Y DTD +
Sbjct: 690 TGATNGRLPCLAISSSVTSYGRQMIEKTKDVVEKRYRIENGYSHDAVVIYGDTDSVMVKF 749
Query: 549 PGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKI 603
E + + Y++ + P + + F ++KK+YA + D K+
Sbjct: 750 GVKTLPEAMKLGEEAANYVSDQFPNPINWSFSTF--PYLLISKKRYAGLFWTRTDTYDKM 807
Query: 604 VTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIY 663
++G+E VRRD + L +L +V+ A K+V L + +I + VI
Sbjct: 808 DSKGIETVRRDNCPLVSYVIDTALRKMLIDQDVEGAQLFTKKVISDLLQNKIDMSQHVIT 867
Query: 664 EQITRPLSEYKAIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFD 721
+ +++ ++Y A HV +A+R+ + P G + Y++++G + D
Sbjct: 868 KALSK--TDYAAKMAHVELAERMRKRDAGSAPAIGDRVAYVIIKG---AQGDQFYMRSED 922
Query: 722 P-----KKHKYDAEYYIENQVLPAVERI 744
P DA+YY+ENQ+ + RI
Sbjct: 923 PIYVLENNIPIDAKYYLENQLSKPLLRI 950
>pir||A56277 DNA-directed DNA polymerase (EC 2.7.7.7) I - Pyrodictium occultum
Length = 879
Score = 205 bits (515), Expect = 2e-51
Identities = 217/843 (25%), Positives = 354/843 (41%), Gaps = 159/843 (18%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRT-FRPYIYALLKDDSA--IDEVKKITAER 58
++ Y E G +I+ G V +DRT + PY + D + EV +
Sbjct: 54 LLQTMYDGERGVAAAKIYDDRNGIVYVYFDRTGYMPYFLTDIPPDKLQELHEVVRHKGFD 113
Query: 59 HGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAK 118
H ++V ++ + Q++ +V K+ ++ P V +R+K+ +E +I F
Sbjct: 114 HVEVVEKFDLLRWQRR------KVTKIVVKTPDVVRVLRDKVPR------AWEANIKFHH 161
Query: 119 RYLIDKGLTP-----------------------------MEGNEELTF------------ 137
Y+ D GL P G +E T
Sbjct: 162 NYIYDYGLVPGMKYRVGKGRLILLGGEASGDDERHIREIFSGEDESTIEMAVKWLSLFEQ 221
Query: 138 -------LAVDIETLYH-----EGEEFGKGPIIMISYADEEGAKVITWKSI--------- 176
LAVDIE P+I ++ + +EG W+++
Sbjct: 222 PPPKPRRLAVDIEVFTPFKGRIPDPSTASYPVISVAMSSDEG-----WRAVYVLARPGVP 276
Query: 177 ------DLP---YVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG 227
LP +VE+ ER +I ++I + V++T+NGDNFD PYL RA KLG
Sbjct: 277 MNPPRGPLPENLHVEIFDDERALILEAFRLI--SNYPVLLTFNGDNFDLPYLYNRAVKLG 334
Query: 228 IKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTI--------NLPTYTLEAVY 279
I + S V ++ H DL+ +TL+A+
Sbjct: 335 IP--------REYIPFRARSDYVTLEYGFHIDLYKFFSTKAVQAYAFGNAYQEFTLDAIA 386
Query: 280 EAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL----GKEFFPMEAQLAR 335
A+ G+ K +V E+ + + +Y++ DA +T L + + L R
Sbjct: 387 SALLGEHKVEV------ESTVSDLPFFELVRYNVRDADLTLRLTTFNNDLVWSLIILLMR 440
Query: 336 LVGQPVWDVSRSSTG----NLVEWFLLRKAY---ERNELAPNKPDEREYERRLRESYEGG 388
+ P+ DV+RS +L W R+ Y R E+ K R + Y+G
Sbjct: 441 ISKLPLEDVTRSQVSAWVKSLFYWEHRRRGYLIPSREEIIRLKGTTRSEALIKGKKYQGA 500
Query: 389 YVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDV--APQVGHRFCKDF 446
V +P G++ IV LDF SLYPSII N+S +T+N C E + P VGH+ C
Sbjct: 501 LVLDPPSGIYFNIVVLDFASLYPSIIKRWNLSYETVNPVYCPESKLVEVPDVGHKVCMSI 560
Query: 447 PGFIPSLLGNLLEERQKI-KKRMKESKDPVE-KKLLDYRQRAIKILANSYYGYYGYAKAR 504
PG ++G L + R KI KK+ K+ P + + + Q A+K+ N+ YG +G
Sbjct: 561 PGLTSQIVGLLRDYRVKIYKKKAKDKSLPDDVRAWYNTVQAAMKVYINASYGVFGAESFP 620
Query: 505 WYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFV 564
+Y AESVTA GR I ++ G +VLY DTD L+ P ++K +
Sbjct: 621 FYAPPVAESVTAIGRYTIKQTLQKAGELGLRVLYGDTDSLFIWNPD------EDKLRELQ 674
Query: 565 EYINSKLPGLLELEYEGFYARGFFVT----KKKYALIDEEGKIVTRGLEIVRRDWSEIAK 620
EY+ L+LE + Y FVT KK Y E+G I +G+ +R+ E K
Sbjct: 675 EYVEKNFG--LDLEVDKVYK---FVTFSGLKKNYIGAYEDGSIDVKGMVAKKRNTPEFLK 729
Query: 621 ETQAKVLEAILKHGNVDEAVKIVKEVTEKLSK-------YEIPPEKLVIYEQITRPLSEY 673
+ +++L I + ++ +K+ + + E+L K E ++L I + +P+ Y
Sbjct: 730 KEFSEMLAVIGSVKSPEDFIKVRRVIRERLRKVYHGLRDLEFNLDELAIRMALNKPVEAY 789
Query: 674 KAIGP-HVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYY 732
P HV A++L GV+V PG VI ++ ++G + +A + + D E Y
Sbjct: 790 TKNTPQHVKAARQLIRAGVQVLPGDVISFVKVKGKEGVKPVQLA------RLPEVDVEKY 843
Query: 733 IEN 735
+E+
Sbjct: 844 VES 846
>dbj|BAA07579.1| (D38573) DNA polymerase [Pyrodictium occultum]
Length = 914
Score = 205 bits (515), Expect = 2e-51
Identities = 217/843 (25%), Positives = 354/843 (41%), Gaps = 159/843 (18%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRT-FRPYIYALLKDDSA--IDEVKKITAER 58
++ Y E G +I+ G V +DRT + PY + D + EV +
Sbjct: 89 LLQTMYDGERGVAAAKIYDDRNGIVYVYFDRTGYMPYFLTDIPPDKLQELHEVVRHKGFD 148
Query: 59 HGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAK 118
H ++V ++ + Q++ +V K+ ++ P V +R+K+ +E +I F
Sbjct: 149 HVEVVEKFDLLRWQRR------KVTKIVVKTPDVVRVLRDKVPR------AWEANIKFHH 196
Query: 119 RYLIDKGLTP-----------------------------MEGNEELTF------------ 137
Y+ D GL P G +E T
Sbjct: 197 NYIYDYGLVPGMKYRVGKGRLILLGGEASGDDERHIREIFSGEDESTIEMAVKWLSLFEQ 256
Query: 138 -------LAVDIETLYH-----EGEEFGKGPIIMISYADEEGAKVITWKSI--------- 176
LAVDIE P+I ++ + +EG W+++
Sbjct: 257 PPPKPRRLAVDIEVFTPFKGRIPDPSTASYPVISVAMSSDEG-----WRAVYVLARPGVP 311
Query: 177 ------DLP---YVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG 227
LP +VE+ ER +I ++I + V++T+NGDNFD PYL RA KLG
Sbjct: 312 MNPPRGPLPENLHVEIFDDERALILEAFRLI--SNYPVLLTFNGDNFDLPYLYNRAVKLG 369
Query: 228 IKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTI--------NLPTYTLEAVY 279
I + S V ++ H DL+ +TL+A+
Sbjct: 370 IP--------REYIPFRARSDYVTLEYGFHIDLYKFFSTKAVQAYAFGNAYQEFTLDAIA 421
Query: 280 EAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL----GKEFFPMEAQLAR 335
A+ G+ K +V E+ + + +Y++ DA +T L + + L R
Sbjct: 422 SALLGEHKVEV------ESTVSDLPFFELVRYNVRDADLTLRLTTFNNDLVWSLIILLMR 475
Query: 336 LVGQPVWDVSRSSTG----NLVEWFLLRKAY---ERNELAPNKPDEREYERRLRESYEGG 388
+ P+ DV+RS +L W R+ Y R E+ K R + Y+G
Sbjct: 476 ISKLPLEDVTRSQVSAWVKSLFYWEHRRRGYLIPSREEIIRLKGTTRSEALIKGKKYQGA 535
Query: 389 YVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDV--APQVGHRFCKDF 446
V +P G++ IV LDF SLYPSII N+S +T+N C E + P VGH+ C
Sbjct: 536 LVLDPPSGIYFNIVVLDFASLYPSIIKRWNLSYETVNPVYCPESKLVEVPDVGHKVCMSI 595
Query: 447 PGFIPSLLGNLLEERQKI-KKRMKESKDPVE-KKLLDYRQRAIKILANSYYGYYGYAKAR 504
PG ++G L + R KI KK+ K+ P + + + Q A+K+ N+ YG +G
Sbjct: 596 PGLTSQIVGLLRDYRVKIYKKKAKDKSLPDDVRAWYNTVQAAMKVYINASYGVFGAESFP 655
Query: 505 WYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFV 564
+Y AESVTA GR I ++ G +VLY DTD L+ P ++K +
Sbjct: 656 FYAPPVAESVTAIGRYTIKQTLQKAGELGLRVLYGDTDSLFIWNPD------EDKLRELQ 709
Query: 565 EYINSKLPGLLELEYEGFYARGFFVT----KKKYALIDEEGKIVTRGLEIVRRDWSEIAK 620
EY+ L+LE + Y FVT KK Y E+G I +G+ +R+ E K
Sbjct: 710 EYVEKNFG--LDLEVDKVYK---FVTFSGLKKNYIGAYEDGSIDVKGMVAKKRNTPEFLK 764
Query: 621 ETQAKVLEAILKHGNVDEAVKIVKEVTEKLSK-------YEIPPEKLVIYEQITRPLSEY 673
+ +++L I + ++ +K+ + + E+L K E ++L I + +P+ Y
Sbjct: 765 KEFSEMLAVIGSVKSPEDFIKVRRVIRERLRKVYHGLRDLEFNLDELAIRMALNKPVEAY 824
Query: 674 KAIGP-HVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYY 732
P HV A++L GV+V PG VI ++ ++G + +A + + D E Y
Sbjct: 825 TKNTPQHVKAARQLIRAGVQVLPGDVISFVKVKGKEGVKPVQLA------RLPEVDVEKY 878
Query: 733 IEN 735
+E+
Sbjct: 879 VES 881
>gb|AAG35630.1|AF202992_1 (AF202992) DNA polymerase alpha [Xenopus laevis]
Length = 1458
Score = 203 bits (512), Expect = 5e-51
Identities = 174/614 (28%), Positives = 290/614 (46%), Gaps = 53/614 (8%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI----KLPLGRDN 236
+E+ +ER ++ + I + DPDVI+ ++ FD LL+R + K+ R +
Sbjct: 609 IEIALTERTLLGFFLAKIHKIDPDVIVGHDIYGFDLEVLLQRINSCKVPFWSKIGRLRRS 668
Query: 237 SEPKMQ-RMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEI 295
PK+ R G + GRI D+ + I +Y L + I + + I
Sbjct: 669 VMPKLGGRSGFAERNAACGRIICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENI 728
Query: 296 AEAWETGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLV 353
A+ L + + + DAK ++ E P+ Q+ + G +
Sbjct: 729 RNAYNDSVHLLYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERN 788
Query: 354 EWFLLRKAYERNELAPNKP------------------DEREYERRLRESYEGGYVKEPEK 395
E+ LL E N + P+KP D+ + + R + +Y GG V EP+
Sbjct: 789 EYLLLHAFTENNFIVPDKPVFKKMQQTTVEDNDDMGTDQNKNKSRKKAAYAGGLVLEPKV 848
Query: 396 GLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRE-----NCKEYDVAPQVGHRFCKDFPGF 449
G ++ I+ LDF SLYPSII +N+ T++RE ++ D P++ H + G
Sbjct: 849 GFYDKFILLLDFNSLYPSIIQEYNICFTTVHREAPSTQKGEDQDEIPELPHSDLE--MGI 906
Query: 450 IPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCK 508
+P + L+E R+ +K+ MK+ +P D RQ+A+K+ ANS YG G++ +R+Y K
Sbjct: 907 LPREIRKLVERRRHVKQLMKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAK 966
Query: 509 ECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
A VT GR+ + + ++ +V+Y DTD + EE+ + + IN
Sbjct: 967 PLAALVTHQGREILLHTKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEIN 1026
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYALIDEE----GKIVT----RGLEIVRRDWSEIAK 620
K LLE++ +G + + KKKYA + E GK VT +GL+IVRRDW E+AK
Sbjct: 1027 -KSYKLLEIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCELAK 1085
Query: 621 ETQAKVLEAIL----KHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEY--K 674
+ V+ IL + V+ K + E+ E ++ +P + I + +T+ +Y K
Sbjct: 1086 QAGNYVISQILSDQPRDSIVENIQKKLTEIGENVTNGTVPITQYEINKALTKDPQDYPDK 1145
Query: 675 AIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRGDGPI--SKRAIAIEEFDPKKH-KYDAE 730
PHV VA + ++ G KVK G I Y++ + + S+RA A E+ +++ D +
Sbjct: 1146 KSLPHVHVALWINSQGGRKVKAGDTISYVICQDGSNLSASQRAYAQEQLQKQENLSIDTQ 1205
Query: 731 YYIENQVLPAVERI 744
YY+ QV P V RI
Sbjct: 1206 YYLSQQVHPVVARI 1219
>sp|P30315|DPOD_PLAFK DNA POLYMERASE DELTA CATALYTIC CHAIN >gi|323108|pir||A45639 DNA
polymerase delta - Plasmodium falciparum
>gi|7434807|pir||S22573 DNA-directed DNA polymerase (EC
2.7.7.7) delta - malaria parasite (Plasmodium
falciparum) >gi|9941|emb|CAA44289.1| (X62423) DNA
Polymerase delta [Plasmodium falciparum]
>gi|160270|gb|AAA29589.1| (M64715) DNA polymerase-delta
[Plasmodium falciparum]
Length = 1094
Score = 203 bits (511), Expect = 6e-51
Identities = 217/824 (26%), Positives = 362/824 (43%), Gaps = 130/824 (15%)
Query: 4 DADYITEDGKPIIRIFKKEKGEFKVEYD-RTFRPYIYALLKDDSAIDEVKKITAERHGKI 62
D +Y++ PIIRI+ K V + F PY Y DD +++ K+ + +
Sbjct: 110 DKNYVSV---PIIRIYSLRKDGCSVLINVHNFFPYFYVEKPDDFDNEDLIKLEMLMNENL 166
Query: 63 VRITEVEKVQKKFLGRPI---------------EVWKLYLEHPQDVPAIREKIREHPAVV 107
++ + +KK L I + K+ + P+ VP++++ V
Sbjct: 167 NLNSQYKIYEKKILKIEIVKTESLMYFKKNGKKDFLKITVLLPKMVPSLKKYFEGIVHVN 226
Query: 108 D------IFEYDIPFAKRYLIDKGLT---------------------------------- 127
+ ++E ++PF RY+ID +T
Sbjct: 227 NKSIGGIVYEANLPFILRYIIDHKITGSSWINCKKGHYYIRNKNKKISNCTFEIDISYEH 286
Query: 128 --PMEGNEE------LTFLAVDIETLYHEGEEFGKG---PIIMIS---YADEEGAKVIT- 172
P+ E L L+ DIE + +G+ F + PII IS Y E T
Sbjct: 287 VEPITLENEYQQIPKLRILSFDIECIKLDGKGFPEAKNDPIIQISSILYFQGEPIDNCTK 346
Query: 173 -----WKSIDLPYVEVV--SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEK 225
+ +P V+ + E+ +++ + I DPD + YN NFD PY+L R
Sbjct: 347 FIFTLLECASIPGSNVIWFNDEKTLLEAWNEFIIRIDPDFLTGYNIINFDLPYILNRGTA 406
Query: 226 LGIKLP--LGR---------DNS-EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTY 273
L +K LGR D+S K ++ + I GRI FD++ +I+R L +Y
Sbjct: 407 LNLKKLKFLGRIKNVASTVKDSSFSSKQFGTHETKEINIFGRIQFDVYDLIKRDYKLKSY 466
Query: 274 TLEAVYEAIFGKSKEKVYAHEIAEAW-ETGKGLERVAKYSMEDAKVTFELGKE--FFPME 330
TL V + KE V+ + + E+ + +R+A Y ++D + L + F
Sbjct: 467 TLNYVSFEFLKEQKEDVHYSIMNDLQNESPESRKRIATYCIKDGVLPLRLIDKLLFIYNY 526
Query: 331 AQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYV 390
++AR+ G P + V L RK E N + P+ + E YEG V
Sbjct: 527 VEMARVTGTPFVYLLTRGQQIKVTSQLYRKCKELNYVIPST----YMKVNTNEKYEGATV 582
Query: 391 KEPEKGLW-EGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYD--------VAPQVGHR 441
EP KG + E I +LDF SLYPSI+I HN+ TL + N + D + + +
Sbjct: 583 LEPIKGYYIEPISTLDFASLYPSIMIAHNLCYSTLIKSNHEVSDLQNDDITTIQGKNNLK 642
Query: 442 FCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYG 499
F K G +P ++ L+E R+K+K +K K+ + K +L+ RQ A+KI ANS YGY G
Sbjct: 643 FVKKNVKKGILPLIVEELIEARKKVKLLIKNEKNNITKMVLNGRQLALKISANSVYGYTG 702
Query: 500 YAK-ARWYCKECAESVTAWGRQYIDLVRRELE-----SRGFK----VLYIDTDGLYATIP 549
+ + C E A S+T GR I+ + +E S G++ V+Y DTD +
Sbjct: 703 ASSGGQLPCLEVAVSITTLGRSMIEKTKERVESFYCKSNGYEHNSTVIYGDTDSVMVKFG 762
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIV 604
EE E I+ + ++LE+E Y + KK+YA + ++ K+
Sbjct: 763 TNNIEEAMTLGKDAAERISKEFLSPIKLEFEKVYCPYLLLNKKRYAGLLYTNPNKHDKMD 822
Query: 605 TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYE 664
+G+E VRRD+ + ++ VL +L N++ A++ K ++L I LV+ +
Sbjct: 823 CKGIETVRRDFCILIQQMMETVLNKLLIEKNLNSAIEYTKSKIKELLTNNIDMSLLVVTK 882
Query: 665 QITRPLSEYKAIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRG 706
+ + ++Y+ PHV +AK+L + P G + YI+++G
Sbjct: 883 SLGK--TDYETRLPHVELAKKLKQRDSATAPNVGDRVSYIIVKG 924
>pir||S17330 DNA-directed DNA polymerase (EC 2.7.7.7) delta - Plasmodium
falciparum
Length = 1093
Score = 203 bits (510), Expect = 8e-51
Identities = 215/814 (26%), Positives = 357/814 (43%), Gaps = 127/814 (15%)
Query: 14 PIIRIFKKEKGEFKVEYD-RTFRPYIYALLKDDSAIDEVKKITAERHGKIVRITEVEKVQ 72
PIIRI+ K V + F PY Y DD +++ K+ + + ++ + +
Sbjct: 116 PIIRIYSLRKDGCSVLINVHNFFPYFYVEKPDDFDNEDLIKLEMLMNENLNLNSQYKIYE 175
Query: 73 KKFLGRPI---------------EVWKLYLEHPQDVPAIREKIREHPAVVD------IFE 111
KK L I + K+ + P+ VP++++ V + ++E
Sbjct: 176 KKILKIEIVKTESLMYFKKNGKKDFLKITVLLPKMVPSLKKYFEGIVHVNNKSIGGIVYE 235
Query: 112 YDIPFAKRYLIDKGLT------------------------------------PMEGNEE- 134
++PF RY+ID +T P+ E
Sbjct: 236 ANLPFILRYIIDHKITGSSWINCKKGHYYIRNKNKKISNCTFEIDISYEHVEPITLENEY 295
Query: 135 -----LTFLAVDIETLYHEGEEFGKG---PIIMIS---YADEEGAKVIT------WKSID 177
L L+ DIE + +G+ F + PII IS Y E T +
Sbjct: 296 QQIPKLRILSFDIECIKLDGKGFPEAKNDPIIQISSILYFQGEPIDNCTKFIFTLLECAS 355
Query: 178 LPYVEVV--SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLP--LG 233
+P V+ + E+ +++ + I DPD + YN NFD PY+L R L +K LG
Sbjct: 356 IPGSNVIWFNDEKTLLEAWNEFIIRIDPDFLTGYNIINFDLPYILNRGTALNLKKLKFLG 415
Query: 234 R---------DNS-EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIF 283
R D+S K ++ + I GRI FD++ +I+R L +YTL V
Sbjct: 416 RIKNVASTVKDSSFSSKQFGTHETKEINIFGRIQFDVYDLIKRDYKLKSYTLNYVSFEFL 475
Query: 284 GKSKEKVYAHEIAEAW-ETGKGLERVAKYSMEDAKVTFELGKE--FFPMEAQLARLVGQP 340
+ KE V+ + + E+ + +R+A Y ++D + L + F ++AR+ G P
Sbjct: 476 KEQKEDVHYSIMNDLQNESPESRKRIATYCIKDGVLPLRLIDKLLFIYNYVEMARVTGTP 535
Query: 341 VWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-E 399
+ V L RK E N + P+ + E YEG V EP KG + E
Sbjct: 536 FVYLLTRGQQIKVTSQLYRKCKELNYVIPST----YMKVNTNEKYEGATVLEPIKGYYIE 591
Query: 400 GIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYD--------VAPQVGHRFCKDF--PGF 449
I +LDF SLYPSI+I HN+ TL + N + D + + +F K G
Sbjct: 592 PISTLDFASLYPSIMIAHNLCYSTLIKSNHEVSDLQNDDITTIQGKNNLKFVKKNVKKGI 651
Query: 450 IPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK-ARWYCK 508
+P ++ L+E R+K+K +K K+ + K +L+ RQ A+KI ANS YGY G + + C
Sbjct: 652 LPLIVEELIEARKKVKLLIKNEKNNITKMVLNGRQLALKISANSVYGYTGASSGGQLPCL 711
Query: 509 ECAESVTAWGRQYIDLVRRELE-----SRGFK----VLYIDTDGLYATIPGAKHEEIKEK 559
E A S+T GR I+ + +E S G++ V+Y DTD + EE
Sbjct: 712 EVAVSITTLGRSMIEKTKERVESFYCKSNGYEHNSTVIYGDTDSVMVKFGTNNIEEAMTL 771
Query: 560 ALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRD 614
E I+ + ++LE+E Y + KK+YA + ++ K+ +G+E VRRD
Sbjct: 772 GKDAAERISKEFLSPIKLEFEKVYCPYLLLNKKRYAGLLYTNPNKHDKMDCKGIETVRRD 831
Query: 615 WSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYK 674
+ + ++ VL +L N++ A++ K ++L I LV+ + + + ++Y+
Sbjct: 832 FCILIQQMMETVLNKLLIEKNLNSAIEYTKSKIKELLTNNIDMSLLVVTKSLGK--TDYE 889
Query: 675 AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRG 706
PHV +AK+L + P G + YI+++G
Sbjct: 890 TRLPHVELAKKLKQRDSATAPNVGDRVSYIIVKG 923
>pir||T20698 hypothetical protein F10C2.4 - Caenorhabditis elegans
>gi|3875739|emb|CAB04077.1| (Z81497) contains similarity
to Pfam domain: PF00136 (DNA polymerase family B),
Score=1053.2, E-value=0, N=1~cDNA EST yk14b11.3 comes
from this gene~cDNA EST EMBL:T01025 comes from this
gene~cDNA EST yk34g1.3 comes from this gene~cDNA EST
yk14b11.5 com>
Length = 1081
Score = 201 bits (507), Expect = 2e-50
Identities = 173/604 (28%), Positives = 284/604 (46%), Gaps = 52/604 (8%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLP--LGRDNSEPKMQR 243
+E+ ++++ + +RE DPD+I YN NFD PY+L RA+ L + LGR + + R
Sbjct: 343 NEKVLLEKWAEFVREVDPDIITGYNILNFDLPYILDRAKVLSLPQVSHLGRQKEKGSVVR 402
Query: 244 --------MGDSL--AVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAH 293
MG + +++I GRI FD+ V+ R L +YTL +V + KE V H
Sbjct: 403 DAAISSKQMGSRVNKSIDIHGRIIFDVLQVVLRDYKLRSYTLNSVSYQFLSEQKEDV-EH 461
Query: 294 EIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPM--EAQLARLVGQPVWDVSRSST 349
I + G + R+A+Y ++DA + L + + ++AR+ G P+ +
Sbjct: 462 NIIPDLQRGDEQTRRRLAQYCLKDAYLPLRLLDKLMSIINYIEMARVTGVPMNFLLTKGQ 521
Query: 350 GNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-EGIVSLDFRS 408
+ +LR+ + N P E E YEG V +P +G + E I +LDF S
Sbjct: 522 QIKILSMMLRRCKQNNFFLP----VIEANSGDGEGYEGATVIDPIRGFYNEPIATLDFAS 577
Query: 409 LYPSIIITHNVSPDTLNR-----ENCKEYDVAPQVGHRFCKDFP--GFIPSLLGNLLEER 461
LYPSI+I HN+ TL + EN ++Y P G F G +P +L ++L R
Sbjct: 578 LYPSIMIAHNLCYTTLLKSPQGVEN-EDYIRTPS-GQYFATKSKRRGLLPEILEDILAAR 635
Query: 462 QKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQY 521
++ K MK KD ++ + + RQ A+KI ANS YG+ G + C E ++SVTA+GR+
Sbjct: 636 KRAKNDMKNEKDEFKRMVYNGRQLALKISANSVYGFTGATVGKLPCLEISQSVTAFGRKM 695
Query: 522 IDLVRRELE------------SRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINS 569
ID+ + E+E KV+Y DTD + + E L + ++
Sbjct: 696 IDMTKLEVERIYKKGALDGKCPADAKVIYGDTDSVMVKFGVETVAQAMEIGLDAAKEVSK 755
Query: 570 KLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTRGLEIVRRDWSEIAKETQA 624
++LE+E Y+ + KK+YA + D K+ +GLE VRRD + +
Sbjct: 756 IFTPPIKLEFEKVYSPYLLINKKRYAGLYFTKPDVHDKMDCKGLETVRRDNCPLVAKVLG 815
Query: 625 KVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAK 684
LE +L + A+ K L +I L+I +++T+ +Y+A HV +A
Sbjct: 816 VCLEKLLIERDQQSALDFAKRTISDLLCNKIDISLLIISKELTKSGDKYQAKQAHVELAA 875
Query: 685 RLAAKGVKVKP--GMVIGYIVLRG--DGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPA 740
R+ + P G + Y+ + + P +RA D ++Y+ NQ+
Sbjct: 876 RMKKRDAGSAPRLGDRVPYVFVAAAKNVPAYERAEDPTFVLQNNIPLDTKHYLTNQLAKP 935
Query: 741 VERI 744
+ RI
Sbjct: 936 LARI 939
>sp|O89042|DPOA_RAT DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|3676242|emb|CAA09720.1|
(AJ011605) DNA polymerase alpha subunit I [Rattus
norvegicus]
Length = 1451
Score = 201 bits (505), Expect = 3e-50
Identities = 165/617 (26%), Positives = 291/617 (46%), Gaps = 55/617 (8%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI----KLPLGRDN 236
VEV ++ER ++ + + + DPD+++ +N F+ LL+R + + K+ R +
Sbjct: 616 VEVAATERTLLGFFLAKVHKLDPDILVGHNICGFELEVLLQRINECKVPFWSKIGRLRRS 675
Query: 237 SEPKM-QRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEI 295
+ PK+ R G GR+ D+ ++ I+ +Y L + + I + + I
Sbjct: 676 NMPKLGSRSGFGERNATCGRMICDVEISVKELIHCKSYHLSELVQQILKTERIVIPTENI 735
Query: 296 AEAWETGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLV 353
+ L + ++ +DA+ ++ E P+ Q+ + G +
Sbjct: 736 RNMYSEPSHLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERN 795
Query: 354 EWFLLRKAYERNELAPNKP------------------DEREYER-RLRESYEGGYVKEPE 394
E+ LL YE N + P+K D +Y++ R + +Y GG V +P+
Sbjct: 796 EFLLLHAFYENNYIVPDKQIFRKPQQKPGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPK 855
Query: 395 KGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFP------ 447
G ++ I+ LDF SLYPSII N+ T+ R + + P
Sbjct: 856 VGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASETLKATEDEEQEQIPELPDPNLDM 915
Query: 448 GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWY 506
G +P + L+E R+++K+ MK+ +P D RQ+A+K+ ANS YG G++ +R+Y
Sbjct: 916 GILPREIRKLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFY 975
Query: 507 CKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEY 566
K A VT GR+ + + ++ +V+Y DTD + EE+ + K
Sbjct: 976 AKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKNE 1035
Query: 567 INSKLPGLLELEYEGFYARGFFVTKKKYALI----DEEGKIVT----RGLEIVRRDWSEI 618
+N KL LLE++ +G + + KKKYA + +G +T +GL+IVRRDW ++
Sbjct: 1036 VN-KLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDL 1094
Query: 619 AKETQAKVLEAILKHGNVDEAVKIVK----EVTEKLSKYEIPPEKLVIYEQITRPLSEY- 673
AK+T V+ IL + D V+ ++ E+ E + +P + I + +T+ +Y
Sbjct: 1095 AKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYP 1154
Query: 674 -KAIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRGDG---PISKRAIAIEEFDPKKH-KY 727
K PHV VA + ++ G KVK G + Y++ + DG P ++RA A E+ + +
Sbjct: 1155 DKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQ-DGSNLPATQRAYAPEQLQKQDNLAI 1213
Query: 728 DAEYYIENQVLPAVERI 744
D +YY+ Q+ P V RI
Sbjct: 1214 DTQYYLAQQIHPVVARI 1230
>gi|8393995 polymerase (DNA-directed), alpha; polymerase (DNA-directed), alpha
(70kD) [Homo sapiens] >gi|118832|sp|P09884|DPOA_HUMAN DNA
POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|67029|pir||DJHUAC
DNA-directed DNA polymerase (EC 2.7.7.7) alpha catalytic
chain - human >gi|35568|emb|CAA29920.1| (X06745) DNA
polymerase alpha-subunit (AA 1 - 1462) [Homo sapiens]
Length = 1462
Score = 198 bits (498), Expect = 2e-49
Identities = 168/619 (27%), Positives = 285/619 (45%), Gaps = 59/619 (9%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE--------KLGIKLPL 232
VEV ++ER ++ + + + DPD+I+ +N F+ LL+R K+G L
Sbjct: 609 VEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIG---RL 665
Query: 233 GRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYA 292
R N R G GR+ D+ + I +Y L + + I + +
Sbjct: 666 KRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPM 725
Query: 293 HEIAEAWETGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTG 350
I + L + +++ +DAK ++ E P+ Q+ + G +
Sbjct: 726 ENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRS 785
Query: 351 NLVEWFLLRKAYERNELAPNKP------------------DEREYER-RLRESYEGGYVK 391
E+ LL YE N + P+K D +Y++ R + +Y GG V
Sbjct: 786 ERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKGAYAGGLVL 845
Query: 392 EPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFP--- 447
+P+ G ++ I+ LDF SLYPSII N+ T+ R + V + P
Sbjct: 846 DPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPS 905
Query: 448 ---GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKA 503
G +P + L+E R+++K+ MK+ +P D RQ+A+K+ ANS YG G++ +
Sbjct: 906 LEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYS 965
Query: 504 RWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKF 563
R+Y K A VT GR+ + + ++ +V+Y DTD + EE+ + K
Sbjct: 966 RFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKV 1025
Query: 564 VEYINSKLPGLLELEYEGFYARGFFVTKKKYALI----DEEGKIVT----RGLEIVRRDW 615
+N KL LLE++ +G + + KKKYA + +G VT +GL+IVRRDW
Sbjct: 1026 KSEVN-KLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDW 1084
Query: 616 SEIAKETQAKVLEAILKHGNVDEAVKIVK----EVTEKLSKYEIPPEKLVIYEQITRPLS 671
++AK+T V+ IL + D V+ ++ E+ E + +P + I + +T+
Sbjct: 1085 CDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQ 1144
Query: 672 EY--KAIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRGDGPI--SKRAIAIEEFDPKKH- 725
+Y K PHV VA + ++ G KVK G + Y++ + + S+RA A E+ + +
Sbjct: 1145 DYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNL 1204
Query: 726 KYDAEYYIENQVLPAVERI 744
D +YY+ Q+ P V RI
Sbjct: 1205 TIDTQYYLAQQIHPVVARI 1223
>sp|P95690|DPOL_SULAC DNA POLYMERASE I >gi|2129430|pir||JC5186 DNA-directed DNA
polymerase (EC 2.7.7.7) - Sulfolobus acidocaldarius
>gi|1685082|gb|AAC44598.1| (U33846) DNA polymerase
[Sulfolobus acidocaldarius]
Length = 875
Score = 196 bits (493), Expect = 8e-49
Identities = 207/859 (24%), Positives = 374/859 (43%), Gaps = 154/859 (17%)
Query: 2 IIDADYITEDGKPIIRIFKKEKGEFKVEYDRT-FRPYIYALLKDDSAIDEVKKITAERHG 60
++ DY + + + +++ KE + + D + +PY D D+V KIT
Sbjct: 52 LLQVDYDGKKSRAVCKLYDKEGKKIYIMQDESGHKPYFLT----DIDPDKVNKIT----- 102
Query: 61 KIVR---ITEVEKVQK--KFLGRPIEVWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIP 115
K+VR +E + K + G+ I + K+ ++ P V +R + + +E I
Sbjct: 103 KVVRDPSFDHLELINKVDPYTGKKIRLTKIVVKDPLAVRRMRSSLPK------AYEAHIK 156
Query: 116 FAKRYLIDKGLTP-----------------MEGNE------------------------- 133
+ Y+ D GL P ++G E
Sbjct: 157 YYNNYVYDNGLIPGLIYKVNKGKLTQLNPELKGEEINEIKKLSDAYEMTKETVNDWIPIL 216
Query: 134 -----ELTFLAVDIETLYHE-----GEEFGKGPIIMISYADEEGAKVIT----------W 173
++ +++DIE E + PII ++ A +G+K++ +
Sbjct: 217 ETEVPDIKRVSLDIEVYTPNRGRIPDPERAEFPIISVALAGNDGSKIVLALKREDVNSDF 276
Query: 174 KSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI---KL 230
D VE+ SE++++ RL ++IRE +++T+NGD+FD PY+ RA +L ++
Sbjct: 277 SKKDGVQVEIFDSEKKLLARLFEIIREYP--MLLTFNGDDFDIPYIYFRALRLNFSPEEV 334
Query: 231 PLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVI-RRTINL-------PTYTLEAVYEAI 282
PL + E K IH DL+ R +++ Y+L AV A+
Sbjct: 335 PLDVVSGEGKFL-----------AGIHIDLYKFFFNRAVSIYAFEGKYSEYSLYAVATAL 383
Query: 283 FGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL----GKEFFPMEAQLARLVG 338
G SK K+ + + + ++++ +Y++ DA++T +L + LAR+
Sbjct: 384 LGISKVKL------DTFISFMDIDKLIEYNLRDAEITLKLTTFNNNLVLKLMVLLARISK 437
Query: 339 QPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLR-------ESYEGGYVK 391
+ +++R+ ++ + +RN L P K + +++ + Y+G V
Sbjct: 438 LGLEELTRTEVSTWIKNLYYWEHRKRNWLIPLKEEILVRSNQVKTAAVIKGKKYKGAVVI 497
Query: 392 EPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENC-KEYDVAPQVG---HRFCKDFP 447
+P G++ +V LDF SLYPSII N+S +T+ + C K+ V + G H C D P
Sbjct: 498 DPPAGVYFNVVVLDFASLYPSIIKNWNISYETIEIDECTKKVWVEDETGEKLHYVCMDKP 557
Query: 448 GFIPSLLGNLLEERQKI-KKRMKESKDPVEKK-LLDYRQRAIKILANSYYGYYGYAKARW 505
G G + + R K+ KK+ K S E++ L D QRA+K+ N+ YG +G
Sbjct: 558 GITAVYQGLIRDFRVKVYKKKAKYSNISEEQRSLYDVVQRAMKVFINATYGVFGAENFPL 617
Query: 506 YCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVE 565
Y AESVTA GR I ++ E KV+Y DTD L+ P K+K + ++
Sbjct: 618 YAPAVAESVTAIGRYIITTTYKQAEKLNLKVIYGDTDSLFLYNP------TKDKLEELIK 671
Query: 566 YINSKLPGLLELEYEGFYAR-GFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQA 624
++ L+LE + Y + KK Y + +GK +G+ +R+ E K+ A
Sbjct: 672 FVKQNFN--LDLEVDNTYKYVAYSGLKKNYFGVYPDGKTEIKGMLAKKRNTPEFIKKEFA 729
Query: 625 KVLEAILKHGNVDEAVKI-------VKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG 677
++ + + ++ ++ +K++ KL + L +++PL Y
Sbjct: 730 EIKNMLASLNSPNDIPEVKNKLEIKIKDIYYKLRNKGYNLDDLAFRIMLSKPLDSYTKNT 789
Query: 678 P-HVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQ 736
P HV +L A GV V P VI ++ ++ + +A K + D E Y+E
Sbjct: 790 PQHVKAGLQLRAFGVNVLPRDVIMFVKVKSKDGVKAYQLA------KISEIDIEKYVET- 842
Query: 737 VLPAVERILRAFGYRKEDL 755
+ E+IL+AFG +++
Sbjct: 843 LRTTFEQILKAFGISWDEI 861
>sp|O93745|DPO1_AERPE DNA POLYMERASE I >gi|7434800|pir||F72763 probable DNA-directed DNA
polymerase (pfu polymerase) APE0099 - Aeropyrum pernix
(strain K1) >gi|5103487|dbj|BAA79008.1| (AP000058) 959aa
long hypothetical DNA-directed DNA polymerase (pfu
polymerase) [Aeropyrum pernix]
Length = 959
Score = 196 bits (493), Expect = 8e-49
Identities = 186/709 (26%), Positives = 322/709 (45%), Gaps = 82/709 (11%)
Query: 84 KLYLEHPQDVPAIREKIREH-------PAVVDIFEYDI----PFAKRYLIDKGLTPMEGN 132
+++ E P++V RE+ RE P + + +DI P A R L D P
Sbjct: 283 EIFREEPREV---RERAREWLRIFEAPPPKLPLIAFDIEVYSPIATR-LPDPSTAPYPVI 338
Query: 133 EELTFLAVD---IETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSERE 189
T + + LY +G EF +G + EG +V E+ SER
Sbjct: 339 SAATADSSGRSRVVLLYRDGVEFTEGAL-------PEGTEV-----------EIYDSERA 380
Query: 190 MIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLA 249
M+ LV++++ +++++NGDNFD PY+ +R E LG+ + SL
Sbjct: 381 MLLDLVRILQRYP--LVVSFNGDNFDLPYIARRLEVLGVPREFAPIELKQDYATFRRSLH 438
Query: 250 VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVA 309
+++ V +LE++ A+ GK K ++ A ++E L ++
Sbjct: 439 IDLHKLFGIRALQVYAFGNKYRELSLESISRALLGKGKVELKA-PVSEL-----NLNKLI 492
Query: 310 KYSMEDAKVTFEL----GKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERN 365
+Y+++DA++T EL F + + R + D++RS N + + + R
Sbjct: 493 EYNLQDARLTLELLTFSNNLVFNLIIMVMRTSKLGIEDITRSQISNWIRGLMYWEHRRRR 552
Query: 366 ELAPNKPD-EREYERRLR-------ESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITH 417
L P++ + E+ R + Y G V +P G++ ++ LDF SLYPS+I
Sbjct: 553 WLIPSRGEIEKLSSAGARVGAIIKDKKYRGAIVLDPPVGIFFRVLVLDFASLYPSLIKQW 612
Query: 418 NVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEK 477
N+S +T+N NC++ P+VGHR C++F G ++G L + R ++ K+ + K E+
Sbjct: 613 NLSYETVNNPNCRDTIEVPEVGHRVCREFKGISNEIVGMLRDFRVRLYKKKSKDKSLREE 672
Query: 478 KLL--DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFK 535
+ L D Q A+K+ N+ YG +G K Y AESVTA GR + +
Sbjct: 673 ERLWYDVVQSAMKVYINASYGVFGSEKFSLYSLPVAESVTALGRAVLRGTLEKSRELNLH 732
Query: 536 VLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA 595
++Y DTD L+ P K+ V+Y+ LEL+ + F A F KK Y
Sbjct: 733 IVYGDTDSLFIWDPP------KDVLNDLVDYVERTYGLELELD-KVFRAILFSGLKKNYL 785
Query: 596 LIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSK-YE 654
I EEG IV +G+ + + E K+ +K ++ + K ++ I+ E+ + ++ Y
Sbjct: 786 GITEEGDIVIKGMVAKKSNTPEFIKDEFSKAVKILSKLEKPEDVEAILAELRDHINTVYN 845
Query: 655 IPPEKLVIYEQ------ITRPLSEYKAIGP-HVAVAKRLAAKGVKVKPGMVIGYIVLRGD 707
+K+ +Q +++ EY P HV A L G+ + G ++ Y+ R
Sbjct: 846 NVKKKVYTLDQFAIKVMLSKNPREYDKNTPQHVKAAMLLQRLGLTLSRGDIVYYVKTRDK 905
Query: 708 GPISKRAIA-IEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDL 755
+ +A + + DP K Y+E+ V A E++L AFG +D+
Sbjct: 906 LGVKPVQLARLSDVDPGK-------YVEH-VKTAFEQMLMAFGISWDDI 946
>sp|O48653|DPOA_ORYSA DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|2826900|dbj|BAA24573.1|
(AB004461) DNA polymerase alpha catalytic subunit [Oryza
sativa]
Length = 1243
Score = 195 bits (490), Expect = 2e-48
Identities = 176/645 (27%), Positives = 292/645 (44%), Gaps = 94/645 (14%)
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI------KLPLGRDNSE 238
SSER ++ RL+ + + D DV++ +N FD LL RA+ + K+ R +
Sbjct: 359 SSERALLNRLMIELSKLDCDVLVGHNISGFDLDVLLHRAQTCKVPSNMWSKIGRLRRSVM 418
Query: 239 PKMQRMGDSLAVE---------IKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
P++ + G++L I GR+ D + R + +Y+L + E K +++
Sbjct: 419 PRLTK-GNTLYGSGASPGIMSCIAGRLLCDTYLCSRDLLKEVSYSLTQLAETQLKKERKE 477
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVSRS 347
V H+I +++ L ++ +Y DA + EL P+ QL + G +
Sbjct: 478 VSPHDIPPMFQSSGALLKLVEYGETDACLALELMFHLSVLPLTRQLTNISGNLWGKTLQG 537
Query: 348 STGNLVEWFLLRKAYERNELAPNK----------------------PDEREY-------- 377
S VE+ LL + R + P+K PDE +
Sbjct: 538 SRAQRVEYLLLHAFHARKFIVPDKFARSKEFNSTKRKMNPDTEAARPDEADPSIDDEGHH 597
Query: 378 ----ERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKEY 432
+ + SY GG V EP+KGL++ ++ LDF SLYPSII +N+ T++R
Sbjct: 598 VDQGKTKKGPSYAGGLVLEPKKGLYDKYVLLLDFNSLYPSIIQEYNICFTTVDRSADGNV 657
Query: 433 DVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILAN 492
P G +P LL +L+E R+ +K +K + ++++ D +Q+A+K+ AN
Sbjct: 658 PNLP------ASKTTGVLPELLKSLVERRRMVKSWLKTASG-LKRQQFDIQQQALKLTAN 710
Query: 493 SYYGYYGYAKARWYCKECAESVTAWGRQY----IDLVRRELESRGFKVLYIDTDGLYATI 548
S YG G++ +R+Y K AE +T GR+ +DLV+ L +V+Y DTD +
Sbjct: 711 SMYGCLGFSNSRFYAKPLAELITLQGREILQNTVDLVQNNL---NLEVIYGDTDSIMIHT 767
Query: 549 PGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI------DEEGK 602
K A K ++ +N K LE++ +G Y R + KKKYA I
Sbjct: 768 GLDDISRAKGIAGKVIQEVNKKY-RCLEIDLDGIYKRMLLLKKKKYAAIKVALDGSLREN 826
Query: 603 IVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVK----EVTEKLSKYEIPPE 658
I +GL++VRRDWS ++KE L IL G+ D+ ++ + +V E++ + E
Sbjct: 827 IERKGLDMVRRDWSLLSKEIGDFCLNQILSGGSCDDVIESIHSSLVQVQEQMRGGQTELE 886
Query: 659 KLVIYEQITRPLSEYKAI--GPHVAVAKRLAAKGVK-VKPGMVIGYIVLRGDGPISKRAI 715
K +I + +T+ +Y PHV VA RL G G + YI+ S +
Sbjct: 887 KYIITKSLTKAPEDYPDAKNQPHVQVALRLKQNGYSGCSAGDTVPYIICSQQDSESTHSE 946
Query: 716 AIE------EFDPKKHKYD-------AEYYIENQVLPAVERILRA 747
I+ E + K+ Y A YY++ ++ P V R+ A
Sbjct: 947 RIDSQRAQREPEGWKNLYTMVCLRILASYYLQQRINPVVSRVCAA 991
>sp|P21189|DPO2_ECOLI DNA POLYMERASE II (POL II) >gi|67056|pir||JDEC22 DNA-directed DNA
polymerase (EC 2.7.7.7) II - Escherichia coli
>gi|285766|dbj|BAA01331.1| (D10483) DNA polymerase II
[Escherichia coli] >gi|581193|emb|CAA38616.1| (X54847)
DNA polymerase II [Escherichia coli]
>gi|1786246|gb|AAC73171.1| (AE000116) DNA polymerase II
[Escherichia coli K12] >gi|227827|prf||1712306B DNA
polymerase:ISOTYPE=II [Escherichia coli]
Length = 783
Score = 195 bits (490), Expect = 2e-48
Identities = 202/748 (27%), Positives = 342/748 (45%), Gaps = 107/748 (14%)
Query: 82 VWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTP---MEGNEE---- 134
V+ LY + + +++RE V ++E D+ +RYL+++ +T +EG+
Sbjct: 78 VYGLYCRAHRQLMNYEKRLRE--GGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTI 135
Query: 135 --------------LTFLAVDIETLYHEGEEF-----GKGPIIMISYADEEGAKVITWKS 175
L ++++DIET H GE + G G I+ E G S
Sbjct: 136 VNARLKPHPDYRPPLKWVSIDIETTRH-GELYCIGLEGCGQRIVYMLGPENGDA----SS 190
Query: 176 IDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD 235
+D +E V+S +++++L DPDVII +N FD L K AE+ + L LGRD
Sbjct: 191 LDFE-LEYVASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGRD 249
Query: 236 NSEPKMQRMGDSLAV---EIKGRIHFDLFPVIRRTI-NLPTYTLEAVYEAIFGKSKEKVY 291
NSE + + G V + KGR+ D ++ N +++LE V + + G+ K
Sbjct: 250 NSELEWREHGFKNGVFFAQAKGRLIIDGIEALKSAFWNFSSFSLETVAQELLGEGKS--- 306
Query: 292 AHEIAEAWETGKGLER--------VAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPV 341
I W+ ++R +A Y+++D ++ ++ E P + A + G PV
Sbjct: 307 ---IDNPWDRMDEIDRRFAEDKPALATYNLKDCELVTQIFHKTEIMPFLLERATVNGLPV 363
Query: 342 --WDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE 399
S ++ G+L + R Y +APN + + + GGYV + GL++
Sbjct: 364 DRHGGSVAAFGHLYFPRMHRAGY----VAPNLGEVPPH------ASPGGYVMDSRPGLYD 413
Query: 400 GIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLE 459
++ LD++SLYPSII T + P L E P H GF+ +
Sbjct: 414 SVLVLDYKSLYPSIIRTFLIDPVGL-----VEGMAQPDPEH----STEGFLDAWFSREKH 464
Query: 460 ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR 519
+I + +D +++ +A+KI+ N++YG G R++ A S+T G
Sbjct: 465 CLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGVLGTTACRFFDPRLASSITMRGH 524
Query: 520 QYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEK-ALKFVEYINS--------- 569
Q + + +E++G+ V+Y DTD + + GA EE K V+++N+
Sbjct: 525 QIMRQTKALIEAQGYDVIYGDTDSTFVWLKGAHSEEEAAKIGRALVQHVNAWWAETLQKQ 584
Query: 570 KLPGLLELEYEGFYARGFFVT--------KKKYALIDEEG---KIVTRGLEIVRRDWSEI 618
+L LELEYE + R T KK+YA + +EG ++V +GLE VR DW+ +
Sbjct: 585 RLTSALELEYETHFCRFLMPTIRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPL 644
Query: 619 AKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEY-KAIG 677
A++ Q ++ I ++ E V+E +KL E+ +LV +++ RPLSEY + +
Sbjct: 645 AQQFQQELYLRIFRNEPYQE---YVRETIDKLMAGEL-DARLVYRKRLRRPLSEYQRNVP 700
Query: 678 PHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
PHV A+ A K G + Y RG E D ++ D E+Y+ Q+
Sbjct: 701 PHVRAAR--LADEENQKRGRPLQY-QNRGTIKYVWTTNGPEPLDYQRSPLDYEHYLTRQL 757
Query: 738 LPAVERILRAFGYRKEDLKYQKTKQVGL 765
P E IL + +++ T Q+GL
Sbjct: 758 QPVAEGIL---PFIEDNFATLMTGQLGL 782
>dbj|BAB10944.1| (AB020742) DNA polymerase alpha 1 [Arabidopsis thaliana]
Length = 1492
Score = 194 bits (488), Expect = 3e-48
Identities = 166/644 (25%), Positives = 306/644 (46%), Gaps = 92/644 (14%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI------KLPLGR 234
+ + +SER ++ RL + + D D+++ +N FD LL+RA+ + K+ +
Sbjct: 643 LSIENSERALLNRLFLELNKLDSDILVGHNISGFDLDVLLQRAQACKVQSSMWSKIGRLK 702
Query: 235 DNSEPKMQRMGD-------SLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSK 287
+ PK++ + L I GR+ D R + +Y+L + + + +
Sbjct: 703 RSFMPKLKGNSNYGSGATPGLMSCIAGRLLCDTDLCSRDLLKEVSYSLTDLSKTQLNRDR 762
Query: 288 EKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVS 345
+++ ++I + +++ K L + + DA ++ EL P+ QL + G
Sbjct: 763 KEIAPNDIPKMFQSSKTLVELIECGETDAWLSMELMFHLSVLPLTLQLTNISGNLWGKTL 822
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNK------------------PDEREYER-------- 379
+ + +E++LL + + + P+K P++R +
Sbjct: 823 QGARAQRIEYYLLHTFHSKKFILPDKISQRMKEIKSSKRRMDYAPEDRNVDELDADLTLE 882
Query: 380 ---------RLRESYEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENC 429
+ +Y GG V EP++GL++ ++ LDF SLYPSII +N+ T+ R
Sbjct: 883 NDPSKGSKTKKGPAYAGGLVLEPKRGLYDKYVLLLDFNSLYPSIIQEYNICFTTIPRSE- 941
Query: 430 KEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKI 489
D P++ PG +P L+ +L+ R+ +K +MK+ + ++ LD RQ+A+K+
Sbjct: 942 ---DGVPRLP---SSQTPGILPKLMEHLVSIRKSVKLKMKK-ETGLKYWELDIRQQALKL 994
Query: 490 LANSYYGYYGYAKARWYCKECAESVTAWGR----QYIDLVRRELESRGFKVLYIDTDGLY 545
ANS YG G++ +R+Y K AE +T GR + +DLV+ L +V+Y DTD +
Sbjct: 995 TANSMYGCLGFSNSRFYAKPLAELITLQGRDILQRTVDLVQNHL---NLEVIYGDTDSIM 1051
Query: 546 ATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALID---EEGK 602
EE+K K ++ +N K L+++ +G Y R + KKKYA + ++GK
Sbjct: 1052 IHSGLDDIEEVKAIKSKVIQEVNKKY-RCLKIDCDGIYKRMLLLRKKKYAAVKLQFKDGK 1110
Query: 603 ----IVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIV----KEVTEKLSKYE 654
I +G+++VRRDWS ++KE L IL G+ ++ V+ + ++ E++ +
Sbjct: 1111 PCEDIERKGVDMVRRDWSLLSKEIGDLCLSKILYGGSCEDVVEAIHNELMKIKEEMRNGQ 1170
Query: 655 IPPEKLVIYEQITRPLSEY--KAIGPHVAVAKRLAAKGVK--VKPGMVIGYIVLRGDG-- 708
+ EK VI + +T+P + Y PHV VA R+ +G K + YI+ G
Sbjct: 1171 VALEKYVITKTLTKPPAAYPDSKSQPHVQVALRMRQRGYKEGFNAKDTVPYIICYEQGNA 1230
Query: 709 ------PISKRAIAIEEFDPKKHKY--DAEYYIENQVLPAVERI 744
I++RA +E + ++ D +YY+ Q+ P V R+
Sbjct: 1231 SSASSAGIAERARHPDEVKSEGSRWLVDIDYYLAQQIHPVVSRL 1274
>dbj|BAA75662.1| (AB017500) DNA polymerase [Aeropyrum pernix]
Length = 923
Score = 193 bits (485), Expect = 7e-48
Identities = 160/598 (26%), Positives = 282/598 (46%), Gaps = 46/598 (7%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPK 240
VE+ SER M+ LV++++ +++++NGDNFD PY+ +R E LG+ +
Sbjct: 336 VEIYDSERAMLLDLVRILQRYP--LVVSFNGDNFDLPYIARRLEVLGVPREFAPIELKQD 393
Query: 241 MQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
SL +++ V +LE++ A+ GK K ++ A ++E
Sbjct: 394 YATFRRSLHIDLHKLFGIRALQVYAFGNKYRELSLESISRALLGKGKVELKA-PVSEL-- 450
Query: 301 TGKGLERVAKYSMEDAKVTFEL----GKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWF 356
L ++ +Y+++DA++T EL F + + R + D++RS N +
Sbjct: 451 ---NLNKLIEYNLQDARLTLELLTFSNNLVFNLIIMVMRTSKLGIEDITRSQISNWIRGL 507
Query: 357 LLRKAYERNELAPNKPD-EREYERRLR-------ESYEGGYVKEPEKGLWEGIVSLDFRS 408
+ + R L P++ + E+ R + Y G V +P G++ ++ LDF S
Sbjct: 508 MYWEHRRRGWLVPSRGEIEKLSSAGARVGAIIKDKKYRGAIVLDPPVGIFFRVLVLDFAS 567
Query: 409 LYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRM 468
LYPS+I N+S +T+N NC++ P+VGHR C++F G ++G L + R ++ K+
Sbjct: 568 LYPSLIKQWNLSYETVNNPNCRDTIEVPEVGHRVCREFKGISNEIVGMLRDFRVRLYKKK 627
Query: 469 KESKDPVEKKLL--DYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVR 526
+ K E++ L D Q A+K+ N+ YG +G K Y AESVTA GR +
Sbjct: 628 SKDKSLREEERLWYDVVQSAMKVYINASYGVFGSEKFSLYSLPVAESVTALGRAVLRGTL 687
Query: 527 RELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARG 586
+ ++Y DTD L+ P K+ V+Y+ LEL+ + F A
Sbjct: 688 EKSRELNLHIVYGDTDSLFIWDPP------KDVLNDLVDYVERTYGLELELD-KVFRAIL 740
Query: 587 FFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEV 646
F KK Y I EEG IV +G+ + + E K+ +K ++ + + ++ I+ E+
Sbjct: 741 FSGLKKNYLGITEEGDIVIKGMVAKKSNTPEFIKDEFSKAVKILSRLEKPEDVEAILAEL 800
Query: 647 TEKLSK-YEIPPEKLVIYEQ------ITRPLSEYKAIGP-HVAVAKRLAAKGVKVKPGMV 698
+ ++ Y +K+ +Q +++ EY P HV A L G+ + G +
Sbjct: 801 RDHINTVYNNVKKKVYTLDQFAIKVMLSKNPREYDKNTPQHVKAAMLLQRLGLTLSRGDI 860
Query: 699 IGYIVLRGDGPISKRAIA-IEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDL 755
+ Y+ R + +A + + DP K Y+E+ V A E++L AFG +D+
Sbjct: 861 VYYVKTRDKLGVKPVQLARLSDVDPGK-------YVEH-VKTAFEQMLMAFGISWDDI 910
>gi|6679409 DNA polymerase alpha 1, 180 kDa [Mus musculus]
>gi|544185|sp|P33609|DPOA_MOUSE DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT >gi|631664|pir||S45628 DNA-directed DNA
polymerase (EC 2.7.7.7) alpha 180K chain - mouse
>gi|442471|dbj|BAA04202.1| (D17384) DNA polymerase alpha
catalytic subunit p180 [Mus musculus]
>gi|475159|dbj|BAA40003.1| (D13543) DNA polymerase alpha
catalytic subunit [Mus musculus]
Length = 1465
Score = 192 bits (483), Expect = 1e-47
Identities = 160/616 (25%), Positives = 287/616 (45%), Gaps = 53/616 (8%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI----KLPLGRDN 236
VE+ ++ER +I + + + DPD+++ +N +F+ LL+R + + K+ R +
Sbjct: 613 VEIAATERTLIGFFLAKVHKIDPDILVGHNICSFELEVLLQRINECKVPYWSKIGRLRRS 672
Query: 237 SEPKM-QRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEI 295
+ PK+ R G GR+ D+ + I+ +Y L + + I + + I
Sbjct: 673 NMPKLGSRSGFGERNATCGRMICDVEISAKELIHCKSYHLSELVQQILKTERIVIPTENI 732
Query: 296 AEAWETGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLV 353
+ L + ++ +DA+ ++ E P+ Q+ + G +
Sbjct: 733 RNMYSESSYLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERN 792
Query: 354 EWFLLRKAYERNELAPNKP------------------DEREYER-RLRESYEGGYVKEPE 394
E+ LL YE N + P+K D +Y++ R + +Y GG V +P+
Sbjct: 793 EFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKATYAGGLVLDPK 852
Query: 395 KGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFP------ 447
G ++ I+ LDF SLYPSII N+ T+ R + + P
Sbjct: 853 VGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVTSEVQKATEDEEQEQIPELPDPNLEM 912
Query: 448 GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWY 506
G +P + L+E R+++K+ MK+ +P D RQ+A+K+ ANS YG G++ +R+Y
Sbjct: 913 GILPREIRKLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFY 972
Query: 507 CKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEY 566
K A VT GR+ + + ++ +V+Y DTD + EE+ + K
Sbjct: 973 AKPLAALVTYKGREILMHTKDMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSE 1032
Query: 567 INSKLPGLLELEYEGFYARGFFVTKKKYALI----DEEGKIVT----RGLEIVRRDWSEI 618
+N KL LLE++ + + + KKKYA + +G +T +GL+IVRRDW ++
Sbjct: 1033 VN-KLYKLLEIDIDAVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDL 1091
Query: 619 AKETQAKVLEAILKHGNVDEAVKIVK----EVTEKLSKYEIPPEKLVIYEQITRPLSEY- 673
AK+T V+ IL + D V+ ++ E+ E + +P + I + +T+ +Y
Sbjct: 1092 AKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYP 1151
Query: 674 -KAIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRGDGPI--SKRAIAIEEFDPKKH-KYD 728
+ PHV VA + ++ G KVK G + Y++ + + ++RA A E+ + D
Sbjct: 1152 DRKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTATQRAYAPEQLQKLDNLAID 1211
Query: 729 AEYYIENQVLPAVERI 744
+YY+ Q+ P V RI
Sbjct: 1212 TQYYLAQQIHPVVARI 1227
>gb|AAA63764.1| (M38283) DNA polymerase II [Escherichia coli]
Length = 783
Score = 191 bits (480), Expect = 3e-47
Identities = 201/748 (26%), Positives = 341/748 (44%), Gaps = 107/748 (14%)
Query: 82 VWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTP---MEGNEE---- 134
V+ LY + + +++RE V ++E D+ +RYL+++ +T +EG+
Sbjct: 78 VYGLYCRAHRQLMNYEKRLRE--GGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTI 135
Query: 135 --------------LTFLAVDIETLYHEGEEF-----GKGPIIMISYADEEGAKVITWKS 175
L ++++DIET H GE + G G I+ E G S
Sbjct: 136 VNARLKPHPDYRPPLKWVSIDIETTRH-GELYCIGLEGCGQRIVYMLGPENGDA----SS 190
Query: 176 IDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD 235
+D +E V+S +++++L DPDVII +N FD L K AE+ + L LGRD
Sbjct: 191 LDFE-LEYVASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGRD 249
Query: 236 NSEPKMQRMGDSLAV---EIKGRIHFDLFPVIRRTI-NLPTYTLEAVYEAIFGKSKEKVY 291
NSE + + G V + KG + D ++ N +++LE V + + G+ K
Sbjct: 250 NSELEWRDDGFKNGVFFAQAKGGLIIDGIEALKSAFWNFSSFSLETVAQELLGEGKS--- 306
Query: 292 AHEIAEAWETGKGLER--------VAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPV 341
I W+ ++R +A Y+++D ++ ++ E P + A + G PV
Sbjct: 307 ---IDNPWDRMDEIDRRFAEDKPALATYNLKDCELVTQIFHKTEIMPFLLERATVNGLPV 363
Query: 342 --WDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE 399
S ++ G+L + R Y +APN + + + GGYV + GL++
Sbjct: 364 DRHGGSVAAFGHLYFPRMHRAGY----VAPNLGEVPPH------ASPGGYVMDSRPGLYD 413
Query: 400 GIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLE 459
++ LD++SLYPSII T + P L E P H GF+ +
Sbjct: 414 SVLVLDYKSLYPSIIRTFLIDPVGL-----VEGMAQPDPEH----STEGFLDAWFSREKH 464
Query: 460 ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR 519
+I + +D +++ +A+KI+ N++YG G R++ A S+T G
Sbjct: 465 CLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGVLGTTACRFFDPRLASSITMRGH 524
Query: 520 QYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEK-ALKFVEYINS--------- 569
Q + + +E++G+ V+Y DTD + + GA EE K V+++N+
Sbjct: 525 QIMRQTKALIEAQGYDVIYGDTDSTFVWLKGAHSEEEAAKIGRALVQHVNAWWAETLQKQ 584
Query: 570 KLPGLLELEYEGFYARGFFVT--------KKKYALIDEEG---KIVTRGLEIVRRDWSEI 618
+L LELEYE + R T KK+YA + +EG ++V +GLE VR DW+ +
Sbjct: 585 RLTSALELEYETHFCRFLMPTIRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPL 644
Query: 619 AKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEY-KAIG 677
A++ Q ++ I ++ E V+E +KL E+ +LV +++ RPLSEY + +
Sbjct: 645 AQQFQQELYLRIFRNEPYQE---YVRETIDKLMAGEL-DARLVYRKRLRRPLSEYQRNVP 700
Query: 678 PHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQV 737
PHV A+ A K G + Y RG E D ++ D E+Y+ Q+
Sbjct: 701 PHVRAAR--LADEENQKRGRPLQY-QNRGTIKYVWTTNGPEPLDYQRSPLDYEHYLTRQL 757
Query: 738 LPAVERILRAFGYRKEDLKYQKTKQVGL 765
P E IL + +++ T Q+GL
Sbjct: 758 QPVAEGIL---PFIEDNFATLMTGQLGL 782
>sp|Q94636|DPOA_OXYNO DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|7494495|pir||T18560
DNA-directed DNA polymerase (EC 2.7.7.7) alpha chain -
Oxytricha nova >gi|405121|gb|AAA21587.1| (U02001) large
subunit of DNA polymerase alpha [Oxytricha nova]
Length = 1492
Score = 189 bits (474), Expect = 1e-46
Identities = 171/652 (26%), Positives = 302/652 (46%), Gaps = 89/652 (13%)
Query: 180 YVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGI----------K 229
+++ ER++I+ V I + DPD+++ +N F LL R + L I K
Sbjct: 600 FIQFFQHERQLIEAFVAKIYQLDPDLMVAHNLCGGMFDLLLARIQMLKISHWSRIGRLKK 659
Query: 230 LPLGRDNSEPKMQRMGDSLAVEIK---GRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKS 286
+ S+ G S + + GR+ D F + I Y L + + K
Sbjct: 660 NQIPNKKSDQSGANYGGSQWIPRQVTCGRLLVDTFLTAKELIRETNYDLTHLAKVQLQKD 719
Query: 287 KEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK--EFFPMEAQLARLVGQPVWDV 344
+ + + L ++ ++ +DA +T +L + P+ QL + G +
Sbjct: 720 RIDFDDDLLPTFYVQMAKLFQLIDHTEKDAYLTLQLMNHLQVIPLTKQLTNIAGNLWFRS 779
Query: 345 SRSSTGNLVEWFLLRKAYERNELAPNKPDER-----------EYE---------RRLRES 384
+++ E LL + ++ + P+K EYE +R + +
Sbjct: 780 LQNARAERNEMLLLHEFKKKKFVLPDKKQLNAKDLKKNMFADEYEEGDGKTKGGKRKKAA 839
Query: 385 YEGGYVKEPEKGLWEGIVSL-DFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFC 443
Y GG V EP+ G ++ I+ L DF SLYPSII +N+ T+NR K +D ++ +++
Sbjct: 840 YAGGLVIEPKAGFYDNIILLLDFNSLYPSIIQEYNLCFTTVNRRPTKNFD-GSEMKNQYK 898
Query: 444 K-------------DFP--------GFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDY 482
K D P +P +L +L+++R+ +K +MK KD V+ L+
Sbjct: 899 KGENGEEEVDIEEADLPDKNVNLKDAVLPMVLRDLVQKRKAVKDKMKTEKDHVKLSQLEI 958
Query: 483 RQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLYIDT 541
RQ+AIK+ ANS YG G+ +R++ + A +T GR+ + + E++ GF V+Y DT
Sbjct: 959 RQKAIKLTANSMYGCLGFGSSRFHAQAIAALITRTGRETLLRTKDIAENKLGFNVVYGDT 1018
Query: 542 DGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEG 601
D + + ++ E + +N L LE+E +G + + KKKYA + E
Sbjct: 1019 DSIMINTGSNQLQQALEMGKRLKGEVNC-LYKCLEIEIDGVFKSLLLLKKKKYAALKYEN 1077
Query: 602 -------KIV--TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAV----KIVKEVTE 648
K+V +GL++VRRDW ++K VL+ IL +E V + + +
Sbjct: 1078 FLSPAEVKVVQEMKGLDMVRRDWCPLSKRVGRYVLDQILSGKQREEVVLNLNEFLSNIGN 1137
Query: 649 KLSKYEIPPEKLVIYEQITRPLSEYKAI--GPHVAVAKRLAAKGVKVKPGMV---IGYIV 703
+L + I + +I +QIT+ +S+Y I PHVAVAKRL +G K + +V I Y++
Sbjct: 1138 ELKEGTIKLNEFIITKQITKAISDYNDIKGQPHVAVAKRLRDQG-KSENQLVNNFIPYVI 1196
Query: 704 LR---GDGPISKRAIAIEEFDPK-------KHKYDAEYYIENQVLPAVERIL 745
+ GD S A++ + + P K D+++Y+ Q+LP + R++
Sbjct: 1197 CQQTYGDTTKSSTALSDKAYHPDEVISSRGKVTIDSDWYVSTQLLPPITRLI 1248
>gb|AAA24406.1| (M62646) DNA polymerase II [Escherichia coli]
>gi|147320|gb|AAA24407.1| (M35371) DNA polymerase (polB)
(gtg start codon) [Escherichia coli]
Length = 768
Score = 185 bits (464), Expect = 2e-45
Identities = 181/667 (27%), Positives = 311/667 (46%), Gaps = 101/667 (15%)
Query: 82 VWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTP---MEGNEE---- 134
V+ LY + + +++RE V ++E D+ +RYL+++ +T +EG+
Sbjct: 78 VYGLYCRAHRQLMNYEKRLRE--GGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTI 135
Query: 135 --------------LTFLAVDIETLYHEGEEF-----GKGPIIMISYADEEGAKVITWKS 175
L ++++DIET H GE + G I+ E G S
Sbjct: 136 VNARLKPHPDYRPPLKWVSIDIETTRH-GELYCIGLEACGQRIVYMLGPENGDA----SS 190
Query: 176 IDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD 235
+D +E V+S +++++L DPDVII +N FD L K AE+ + L LGRD
Sbjct: 191 LDFE-LEYVASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGRD 249
Query: 236 NSEPKMQRMGDSLAV---EIKGRIHFDLFPVIRRTI-NLPTYTLEAVYEAIFGKSKEKVY 291
NSE + + G V + KGR+ D ++ N +++LE V + + G+ K
Sbjct: 250 NSELEWREHGFKNGVFFAQAKGRLIIDGIEALKSAFWNFSSFSLETVAQELLGEGKS--- 306
Query: 292 AHEIAEAWETGKGLER--------VAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPV 341
I W+ ++R +A Y+++D ++ ++ E P + A + G PV
Sbjct: 307 ---IDNPWDRMDEIDRRFAEDKPALATYNLKDCELVTQIFHKTEIMPFLLERATVNGLPV 363
Query: 342 --WDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE 399
S ++ G+L + R Y +APN + + + GGYV + GL++
Sbjct: 364 DRHGGSVAAFGHLYFPRMHRAGY----VAPNLGEVPPH------ASPGGYVMDSRPGLYD 413
Query: 400 GIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLE 459
++ LD++SLYPSII T + P L E P H GF+ +
Sbjct: 414 SVLVLDYKSLYPSIIRTFLIDPVGL-----VEGMAQPDPEH----STEGFLDAWFSREKH 464
Query: 460 ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR 519
+I + +D +++ +A+KI+ N++YG G R++ A S+T G
Sbjct: 465 CLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGVLGTTACRFFDPRLASSITMRGH 524
Query: 520 QYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALK-FVEYINS--------- 569
Q + + +E++G+ V+Y DTD + + GA EE K + V+++N+
Sbjct: 525 QIMRQTKALIEAQGYDVIYGDTDSTFVWLKGAHSEEEAAKIGRALVQHVNAWWAETLQKQ 584
Query: 570 KLPGLLELEYEGFYARGFFVT--------KKKYALIDEEG---KIVTRGLEIVRRDWSEI 618
+L LELEYE + R T KK+YA + +EG ++V +GLE VR DW+ +
Sbjct: 585 RLTSALELEYETHFCRFLMPTIRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPL 644
Query: 619 AKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEY-KAIG 677
A++ Q ++ I ++ E V+E +KL E+ +LV +++ RPLSEY + +
Sbjct: 645 AQQFQQELYLRIFRNEPYQE---YVRETIDKLMAGELDA-RLVYRKRLRRPLSEYQRNVP 700
Query: 678 PHVAVAK 684
PHV A+
Sbjct: 701 PHVRAAR 707
>sp|P27727|DPOA_TRYBB DNA POLYMERASE ALPHA CATALYTIC SUBUNIT (DNA POLYMERASE I)
>gi|102077|pir||S20052 DNA-directed DNA polymerase (EC
2.7.7.7) alpha catalytic chain - Trypanosoma brucei
brucei >gi|10501|emb|CAA43287.1| (X60951) DNA-directed
DNA polymerase [Trypanosoma brucei]
Length = 1339
Score = 183 bits (461), Expect = 5e-45
Identities = 166/624 (26%), Positives = 286/624 (45%), Gaps = 61/624 (9%)
Query: 178 LPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL--PLGRD 235
+P V +ER ++ + + DPD+I+ +N + LL R ++L I +GR
Sbjct: 498 MPGVHRFINERALLTWFAETLAALDPDIIVGHNIIGYTVETLLNRYQELNIVRWSTIGRL 557
Query: 236 NSE--PKMQRMGDSLAVEIK---GRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKV 290
+ P++Q +LA+E + GR+ D + + R Y L ++ + K
Sbjct: 558 DVRRFPRIQGNNFNLAIEKEACVGRLVVDTYLLAREYYKSTNYKLLSLSTQMEIKGITDN 617
Query: 291 YAHE-------IAEAWETGKGLERVAKYSMEDAKVTFELGK--EFFPMEAQLARLVGQPV 341
H + ++ + + L + + A ++F + + P+ +L L G
Sbjct: 618 RGHFEPGSTVLVKDSMMSSEALCPILLQLLNCAVLSFNVASFLDVIPLTKRLTLLAGNLW 677
Query: 342 WDVSRSSTGNLVEWFLLRKAYERNELAPNKP--------DEREYERRLRESYEGGYVKEP 393
+ +E+ LL + + P+K ++ + E + + Y+GG V EP
Sbjct: 678 SRTLYGARSERIEYLLLHAFHNLKFVTPDKKKRDLKRGREDDDDEGKRKTKYQGGMVLEP 737
Query: 394 EKGLW-EGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPG---- 448
+ GL+ E I+ LDF SLYPS+I NV T++R+ P C
Sbjct: 738 KSGLYSEYILLLDFNSLYPSLIQEFNVCYTTIDRDENTVSAEVPPPESLICLSCRAAGLP 797
Query: 449 -------FIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYA 501
+P ++ L++ R++IK+ MK KDP +L+ RQ A+K+ ANS YG G+
Sbjct: 798 SPCLHKCILPKVIRGLVDSRREIKRMMKSEKDPGNLAMLEIRQLALKLTANSMYGCLGFE 857
Query: 502 KARWYCKECAESVTAWGR----QYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIK 557
+R+Y + AE VT GR ++L+ + S +V+Y DTD + G K + +K
Sbjct: 858 YSRFYAQPLAELVTRQGRLALQNTVELIPQ--ISPSIRVIYGDTDSVMIQ-TGIKDDIVK 914
Query: 558 EKALKF--VEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEGKIVTR---G 607
+ L F +N + LEL+ +G + + KKKYA + EGK+ R G
Sbjct: 915 VRNLGFEIKGKVNQRYQS-LELDIDGVFRAMLLLRKKKYAALSVVDWQGEGKVYKREVKG 973
Query: 608 LEIVRRDWSEIAKETQAKVLEAILK----HGNVDEAVKIVKEVTEKLSKYEI-PPEKLVI 662
L++VRRDW +++ VL+ IL +D +K +K V + + + P E+ VI
Sbjct: 974 LDMVRRDWCPLSQHVSDAVLKRILNAEGGEDILDFVIKYMKGVAQDVRSGNVYPLEEFVI 1033
Query: 663 YEQITRPLSEYKAIG-PHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFD 721
+ +T+ Y G PH VA R+ + V+ G +I Y++ GD I +A I+E
Sbjct: 1034 SKSLTKEPESYHGTGYPHAVVALRMKQRKEGVRVGDLIPYVICEGDEHIDDKAYHIDEVR 1093
Query: 722 PKKH-KYDAEYYIENQVLPAVERI 744
D E+Y+ +Q+ P V R+
Sbjct: 1094 RSDGLSVDVEWYLSSQLYPPVMRL 1117
>sp|Q27152|DPOA_OXYTR DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|7522118|pir||T28158
probable DNA-directed DNA polymerase (EC 2.7.7.7) alpha
catalytic chain - Oxytricha trifallax
>gi|1401224|gb|AAB57771.1| (U59426) DNA polymerase alpha
catalytic subunit [Oxytricha trifallax]
Length = 1513
Score = 183 bits (460), Expect = 6e-45
Identities = 171/653 (26%), Positives = 301/653 (45%), Gaps = 90/653 (13%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIK--LPLGRDNS- 237
++ +ER+MI+ + + DPD+++ +N F LL R + L + +GR
Sbjct: 627 IQKFENERQMIEAFIAKVFIVDPDLVVAHNLCGGMFDLLLARIQYLKVNHWSRIGRLKKT 686
Query: 238 ---EPKMQRMGDSLAVE-------IKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSK 287
K+ G S GR+ D F + + +Y L + + K +
Sbjct: 687 QIPNKKLDFGGSSYGGSQWIPRQVTCGRLLVDTFLSAKELVRETSYDLTYLAKVQLKKDR 746
Query: 288 EKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVS 345
+ + + T + L + ++ +DA +T +L P+ QL + G +
Sbjct: 747 QDFDDELLPTLYITSERLFSLIDHTEKDAYLTIQLMNHLAIIPLTLQLTNIAGNLWFRSL 806
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNK--PDEREYER---------------------RLR 382
+++ E LL + ++ + P+K P ++++R R +
Sbjct: 807 QNARAERNEMLLLHEFKKKKFILPDKKAPFAKDFKRNMFADEFEELKSGKGPKKGGKRKK 866
Query: 383 ESYEGGYVKEPEKGLWEGIVSL-DFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHR 441
+Y GG V EP+ G ++ I+ L DF SLYPSII +N+ T+NR K +D +V +
Sbjct: 867 AAYAGGLVIEPKAGFYDNIILLLDFNSLYPSIIQEYNLCFTTVNRRPTKNFD-GSEVKSQ 925
Query: 442 FCK--------------DFP--------GFIPSLLGNLLEERQKIKKRMKESKDPVEKKL 479
F D P +P++L +L+++R+ +K++MK KD V+
Sbjct: 926 FKAAGTDANEGNEVEEADLPDKNVNVKDAVLPNVLRDLVQKRKAVKEKMKNEKDAVKLSQ 985
Query: 480 LDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESR-GFKVLY 538
L+ RQ+AIK+ ANS YG G+ +R++ + A +T GR + + E++ GF V+Y
Sbjct: 986 LEIRQKAIKLTANSMYGCLGFGSSRFHAQAIAALITKTGRDTLLRTKDIAENKLGFNVVY 1045
Query: 539 IDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALID 598
DTD + + ++ E + L LE+E +G + + KKKYA +
Sbjct: 1046 GDTDSIMINTGTNQLQQSLEMGKRPQGLKLIALYKCLEIEIDGVFKSLLLLKKKKYAALK 1105
Query: 599 EEG------KIV--TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAV----KIVKEV 646
EG K+V +GL++VRRDW ++K VL IL ++ V + + ++
Sbjct: 1106 YEGFGTPDAKVVQEVKGLDMVRRDWCPLSKNVGNFVLNQILSGKQREDVVLNLNEYLSDI 1165
Query: 647 TEKLSKYEIPPEKLVIYEQITRPLSEYKAI--GPHVAVAKRLAAKGVKVKPGMVIGYI-V 703
EK+ I ++ +I +Q+T+ +SEY I PHVAVA+RL +G K + +V +I
Sbjct: 1166 GEKMKNNGITLDQFIITKQLTKAISEYSDIKGQPHVAVAQRLKNQG-KSESDLVNNFIPY 1224
Query: 704 LRGDGPI----SKRAIAIEEFDPK-------KHKYDAEYYIENQVLPAVERIL 745
+ G P + A+A + + P+ K D E+YI QVLP + R++
Sbjct: 1225 VIGAQPFDPSKTNPALAGKAYHPEEVVSSKGKILLDIEWYITMQVLPPITRLI 1277
>gb|AAF55908.1| (AE003735) DNApol-alpha180 gene product [Drosophila melanogaster]
Length = 1472
Score = 182 bits (458), Expect = 1e-44
Identities = 160/602 (26%), Positives = 277/602 (45%), Gaps = 62/602 (10%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKM-QRM 244
SER ++ + ++ D D+I+T+ D+ D + + + +K+P ++ Q
Sbjct: 639 SERALLSWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSF 696
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE----KVYAHEIAEAWE 300
G L GR+ D+ I +Y L+ + + + K KE +V A ++ E +E
Sbjct: 697 GKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVL-KLKESERMEVNADDLLEMYE 755
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
G+ + ++ +M+D L E P+ Q+ + G + + E+ LL
Sbjct: 756 KGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLL 815
Query: 359 RKAYERNELAPNKPD-----------------EREYERRLRESYEGGYVKEPEKGLWEGI 401
+E+N + P+K + + + + +Y GG V EP +GL+E
Sbjct: 816 HAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKY 875
Query: 402 VSL-DFRSLYPSIIITHNVSPDTLNRE-NCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLE 459
V L DF SLYPSII +N+ T+ + + E P K PG +P L L+E
Sbjct: 876 VLLMDFNSLYPSIIQEYNICFTTVQQPVDADELPTLPD-----SKTEPGILPLQLKRLVE 930
Query: 460 ERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWG 518
R+++KK M P + RQ A+K+ ANS YG G+A +R++ + A VT G
Sbjct: 931 SRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKG 990
Query: 519 RQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELE 578
R+ + ++ ++ + V+Y DTD L ++++ + + +N KL LEL+
Sbjct: 991 REILTNTQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVN-KLYKQLELD 1049
Query: 579 YEGFYARGFFVTKKKYALI----DEEGKI----VTRGLEIVRRDWSEIAKETQAKVLEAI 630
+G + + KKKYA I D +G + +GL+IVRRDWS++A VL+ +
Sbjct: 1050 IDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEV 1109
Query: 631 LKHGNVDEAVKIVKEVTEK----LSKYEIPPEKLVIYEQITRPLSEY--KAIGPHVAVAK 684
L ++E + V EK +++ +P VI +Q+TR EY A PHV VA
Sbjct: 1110 LSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVAL 1169
Query: 685 RL-AAKGVKVKPGMVIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVER 743
R+ + + K G + Y ++ + KK + D YY+ +Q+ P V R
Sbjct: 1170 RMNRERNRRYKKGDMRAY-----------HLDELKTSEDKKLQLDTNYYLGHQIHPVVTR 1218
Query: 744 IL 745
++
Sbjct: 1219 MV 1220
>pir||S28079 DNA-directed DNA polymerase (EC 2.7.7.7) alpha - fruit fly
(Drosophila melanogaster)
Length = 1505
Score = 182 bits (456), Expect = 2e-44
Identities = 162/608 (26%), Positives = 286/608 (46%), Gaps = 59/608 (9%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKM-QRM 244
SER ++ + ++ D D+I+T+ D+ D + + + +K+P ++ Q
Sbjct: 639 SERALLSWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSF 696
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE----KVYAHEIAEAWE 300
G L GR+ D+ I +Y L+ + + + K KE +V A ++ E +E
Sbjct: 697 GKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVL-KLKESERMEVNADDLLEMYE 755
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
G+ + ++ +M+D L E P+ Q+ + G + + E+ LL
Sbjct: 756 KGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLL 815
Query: 359 RKAYERNELAPNKPD-----------------EREYERRLRESYEGGYVKEPEKGLWEGI 401
+ E+N + P+K + + + + +Y GG V EP +GL+E
Sbjct: 816 HASTEKNYIVPDKKPVSKRSGAGDTDRTLSGADATMQTKKKAAYAGGLVLEPMRGLYEKY 875
Query: 402 VSL-DFRSLYPSIIITHNVSPDTLNRE-NCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLE 459
V L D SLYPSII +N+ + + + + E P K PG +P L L+E
Sbjct: 876 VLLMDLNSLYPSIIQEYNICFNPVQQPVDADELPTLPD-----SKTEPGILPLQLKRLVE 930
Query: 460 ERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWG 518
R+++KK M P + RQ A+K+ ANS YG G+A +R++ + A VT G
Sbjct: 931 SRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKG 990
Query: 519 RQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELE 578
R + ++ ++ + V+Y DTD L ++++ + + +N KL LEL+
Sbjct: 991 RDLTN-TQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVN-KLYKQLELD 1048
Query: 579 YEGFYARGFFVTKKKYALI----DEEGKI----VTRGLEIVRRDWSEIAKETQAKVLEAI 630
+G + + KKKYA I D +G + +GL+IVRRDWS++A VL+ +
Sbjct: 1049 IDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEV 1108
Query: 631 LKHGNVDEAVKIVKEVTEK----LSKYEIPPEKLVIYEQITRPLSEYK--AIGPHVAVAK 684
L ++E + V EK +++ +P VI +Q+TR +Y+ A PHV VA
Sbjct: 1109 LSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQDYRNSASLPHVQVAL 1168
Query: 685 RL-AAKGVKVKPGMVIGYIVLRGDGPIS---KRAIAIEEF---DPKKHKYDAEYYIENQV 737
R+ + + K G ++ Y++ DG + +RA ++E + KK + D YY+ +Q+
Sbjct: 1169 RMNRERNRRYKKGDMVDYVICL-DGTTNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQI 1227
Query: 738 LPAVERIL 745
P V R++
Sbjct: 1228 HPVVTRMV 1235
>gb|AAB24152.1| (S48157) DNA polymerase-primase 180 kda subunit [Drosophila
melanogaster, Peptide, 1490 aa]
Length = 1490
Score = 181 bits (455), Expect = 2e-44
Identities = 160/607 (26%), Positives = 283/607 (46%), Gaps = 56/607 (9%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKM-QRM 244
SER + + ++ D D+I+T+ D+ D + + + +K+P ++ Q
Sbjct: 641 SERALSVWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSF 698
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIF---GKSKEKVYAHEIAEAWET 301
G L GR+ D+ I +Y L+ + + + G + +V A ++ E +E
Sbjct: 699 GKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKGSERMEVNADDLLEMYEK 758
Query: 302 GKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLR 359
G+ + ++ +M+D L E P+ Q+ + G + + E+ LL
Sbjct: 759 GESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLH 818
Query: 360 KAYERNELAPNKPD-----------------EREYERRLRESYEGGYVKEPEKGLWEGIV 402
+E+N + P+K + + + + +Y GG V EP +GL+E V
Sbjct: 819 AFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKYV 878
Query: 403 SL-DFRSLYPSIIITHNVSPDTLNRE-NCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEE 460
L DF SLYPSII +N+ T+ + + E P K PG +P L L+E
Sbjct: 879 LLMDFNSLYPSIIQEYNICFTTVQQPVDADELPTLPD-----SKTEPGILPLQLKRLVES 933
Query: 461 RQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR 519
R+++KK M P + RQ A+K+ ANS YG G+A +R++ + A VT GR
Sbjct: 934 RKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGR 993
Query: 520 QYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEY 579
+ + ++ ++ + V+Y DTD L ++++ + + +N KL EL+
Sbjct: 994 EILTNTQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVN-KLYKQEELDI 1052
Query: 580 EGFYARGFFVTKKKYALI----DEEGKI----VTRGLEIVRRDWSEIAKETQAKVLEAIL 631
+G + + KKKYA I D +G + +GL+IVRRDWS++A VL+ +L
Sbjct: 1053 DGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVL 1112
Query: 632 KHGNVDEAVKIVKEVTEK----LSKYEIPPEKLVIYEQITRPLSEY--KAIGPHVAVAKR 685
++E + V EK +++ +P VI +Q+TR EY A PHV VA R
Sbjct: 1113 SEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALR 1172
Query: 686 LAAKGVKV-KPGMVIGYIVLRGDGPIS---KRAIAIEEF---DPKKHKYDAEYYIENQVL 738
+ + ++ K G ++ Y++ DG + +RA ++E + KK + D + +Q+
Sbjct: 1173 MNRERNRLYKKGDMVDYVICL-DGTTNLAMQRAYHLDELKTSEDKKLQLDTNLLLGHQIH 1231
Query: 739 PAVERIL 745
P V R++
Sbjct: 1232 PVVTRMV 1238
>sp|P28040|DPOA_SCHPO DNA POLYMERASE ALPHA CATALYTIC SUBUNIT (DNA POLYMERASE I)
>gi|67030|pir||DJZPA DNA-directed DNA polymerase (EC
2.7.7.7) alpha - fission yeast (Schizosaccharomyces
pombe) >gi|5009|emb|CAA41232.1| (X58299) DNA polymerase
catalytic subunit alpha [Schizosaccharomyces pombe]
>gi|2662027|emb|CAB16598.1| (Z99296) dna polymerase alpha
[Schizosaccharomyces pombe] >gi|227842|prf||1712310A DNA
polymerase [Schizosaccharomyces pombe]
Length = 1405
Score = 179 bits (450), Expect = 9e-44
Identities = 167/612 (27%), Positives = 282/612 (45%), Gaps = 64/612 (10%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPY--LLKRAEKLGI----KLPLGRDNSEP 239
SE ++ + +R DPDV Y G +F+ Y LL R ++ I + R + P
Sbjct: 601 SEVSLLNNFLNKVRTYDPDV---YFGHDFEMCYSVLLSRLKERKIHNWSSIGRLRRSEWP 657
Query: 240 KMQRMGDSLAVE---IKGRIHFDLFPVIRRT-INLPTYTLEAVYEAIFGKSKEKVYAHEI 295
+ VE I GR+ DL R+ I +++L + ++ + +
Sbjct: 658 RSFNRSSQQFVEKQIIAGRLMCDLSNDFGRSMIKAQSWSLSEIVLKELDIKRQDINQEKA 717
Query: 296 AEAW-ETGKGLERVAKYSMED----AKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTG 350
++W +T GL + D A V F++ + + L + G W +R+ TG
Sbjct: 718 LQSWTDTAHGLLDYLVHCEIDTFFIAAVAFKI--QMLQLSKNLTNIAGNS-W--ARTLTG 772
Query: 351 NLVE---WFLLRKAYERNELAPNKPD---------------EREYERRLRESYEGGYVKE 392
E + LL + + + P+K + E + ++ Y+GG V E
Sbjct: 773 TRAERNEYILLHEFKKNGYIVPDKQQSIRRHAEAFGAEDGLQEESLGKKKDKYKGGLVFE 832
Query: 393 PEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRE--NCKEYDVAPQVGHRFCKDFPGF 449
P+KGL+E I+ +DF SLYPSII +N+ T++R N D P G
Sbjct: 833 PQKGLYETCILVMDFNSLYPSIIQEYNICFTTVDRSPSNSDSDDQIPDTPSASANQ--GI 890
Query: 450 IPSLLGNLLEERQKIKKRMKE-SKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCK 508
P L+ NL+E R++IK +K+ S P ++ D +Q+A+K+ ANS YG GY K+R+Y +
Sbjct: 891 FPRLIANLVERRRQIKGLLKDNSATPTQRLQWDIQQQALKLTANSMYGCLGYTKSRFYAR 950
Query: 509 ECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
A +T GR+ + + + G +V+Y DTD + +F E +N
Sbjct: 951 PLAVLITYKGREALMNTKELADQMGLQVIYGDTDSVMLNTNVTDKNHALRIGNEFKEKVN 1010
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYAL--IDEEGK--IVTRGLEIVRRDWSEIAKETQA 624
+ LE++ + Y R KKKYA +D +GK + +GL++ RR++ +AKE
Sbjct: 1011 ERY-SKLEIDIDNVYQRMLLHAKKKYAALQLDSQGKPNLDVKGLDMKRREFCTLAKEASK 1069
Query: 625 KVLEAILKHGNVDEAV-----KIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYK--AIG 677
L+ IL G + E V + + +EK+ + P K +I+ ++ + +Y
Sbjct: 1070 FCLDQILS-GELTETVIENIHSYLMDFSEKMRNGKFPANKFIIFNRLGKNPEDYPNGKTM 1128
Query: 678 PHVAVAKRLAAKGVKVKPGMVIGYIVL--RGDGPISKRAIAIEEFDPKKHK--YDAEYYI 733
P V VA + A+G V+ G VI +I+ DG + RA + +E D YY+
Sbjct: 1129 PFVQVALKKKARGENVRVGDVIPFIIAGSDADGHPADRAYSPQEIMNTNSTLVIDYNYYL 1188
Query: 734 ENQVLPAVERIL 745
+Q+LP +ER++
Sbjct: 1189 SHQILPPIERVI 1200
>emb|CAB57881.1| (X69673) DNA-directed DNA polymerase [Schizosaccharomyces pombe]
Length = 1405
Score = 179 bits (450), Expect = 9e-44
Identities = 167/612 (27%), Positives = 282/612 (45%), Gaps = 64/612 (10%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPY--LLKRAEKLGI----KLPLGRDNSEP 239
SE ++ + +R DPDV Y G +F+ Y LL R ++ I + R + P
Sbjct: 601 SEVSLLNNFLNKVRTYDPDV---YFGHDFEMCYSVLLSRLKERKIHNWSSIGRLRRSEWP 657
Query: 240 KMQRMGDSLAVE---IKGRIHFDLFPVIRRT-INLPTYTLEAVYEAIFGKSKEKVYAHEI 295
+ VE I GR+ DL R+ I +++L + ++ + +
Sbjct: 658 RSFNRSSQQFVEKQIIAGRLMCDLSNDFGRSMIKAQSWSLSEIVLKELDIKRQDINQEKA 717
Query: 296 AEAW-ETGKGLERVAKYSMED----AKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTG 350
++W +T GL + D A V F++ + + L + G W +R+ TG
Sbjct: 718 LQSWTDTAHGLLDYLVHCEIDTFFIAAVAFKI--QMLQLSKNLTNIAGNS-W--ARTLTG 772
Query: 351 NLVE---WFLLRKAYERNELAPNKPD---------------EREYERRLRESYEGGYVKE 392
E + LL + + + P+K + E + ++ Y+GG V E
Sbjct: 773 TRAERNEYILLHEFKKNGYIVPDKQQSIRRHAEAFGAEDGLQEESLGKKKDKYKGGLVFE 832
Query: 393 PEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRE--NCKEYDVAPQVGHRFCKDFPGF 449
P+KGL+E I+ +DF SLYPSII +N+ T++R N D P G
Sbjct: 833 PQKGLYETCILVMDFNSLYPSIIQEYNICFTTVDRSPSNSDSDDQIPDTPSASANQ--GI 890
Query: 450 IPSLLGNLLEERQKIKKRMKE-SKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCK 508
P L+ NL+E R++IK +K+ S P ++ D +Q+A+K+ ANS YG GY K+R+Y +
Sbjct: 891 FPRLIANLVERRRQIKGLLKDNSATPTQRLQWDIQQQALKLTANSMYGCLGYTKSRFYAR 950
Query: 509 ECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYIN 568
A +T GR+ + + + G +V+Y DTD + +F E +N
Sbjct: 951 PLAVLITYKGREALMNTKELADQMGLQVIYGDTDSVMLNTNVTDKNHALRIGNEFKEKVN 1010
Query: 569 SKLPGLLELEYEGFYARGFFVTKKKYAL--IDEEGK--IVTRGLEIVRRDWSEIAKETQA 624
+ LE++ + Y R KKKYA +D +GK + +GL++ RR++ +AKE
Sbjct: 1011 ERY-SKLEIDIDNVYQRMLLHAKKKYAALQLDSQGKPNLDVKGLDMKRREFCTLAKEASK 1069
Query: 625 KVLEAILKHGNVDEAV-----KIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYK--AIG 677
L+ IL G + E V + + +EK+ + P K +I+ ++ + +Y
Sbjct: 1070 FCLDQILS-GELTETVIENIHSYLMDFSEKMRNGKFPANKFIIFNRLGKNPEDYPNGKTM 1128
Query: 678 PHVAVAKRLAAKGVKVKPGMVIGYIVL--RGDGPISKRAIAIEEFDPKKHK--YDAEYYI 733
P V VA + A+G V+ G VI +I+ DG + RA + +E D YY+
Sbjct: 1129 PFVQVALKKKARGENVRVGDVIPFIIAGSDADGHPADRAYSPQEIMNTNSTLVIDYNYYL 1188
Query: 734 ENQVLPAVERIL 745
+Q+LP +ER++
Sbjct: 1189 SHQILPPIERVI 1200
>gi|6324227 DNA polymerase I alpha subunit, p180; Pol1p [Saccharomyces
cerevisiae] >gi|1706503|sp|P13382|DPOA_YEAST DNA
POLYMERASE ALPHA CATALYTIC SUBUNIT (DNA POLYMERASE I)
>gi|2131235|pir||S58250 DNA-directed DNA polymerase (EC
2.7.7.7) - yeast (Saccharomyces cerevisiae)
>gi|929851|emb|CAA90524.1| (Z50161) DNA Polymerase I
[Saccharomyces cerevisiae] >gi|1302016|emb|CAA95978.1|
(Z71378) ORF YNL102w [Saccharomyces cerevisiae]
Length = 1468
Score = 178 bits (446), Expect = 3e-43
Identities = 165/630 (26%), Positives = 282/630 (44%), Gaps = 78/630 (12%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL---------- 230
V + ++E+ M+ +++ +DPDVII + N L R L I
Sbjct: 610 VRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAHRMHDLNIPTFSSIGRRLRR 669
Query: 231 ----PLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTIN--LPTYTLEAVYEAIFG 284
GR NS + D + GR+ D+ + +++ ++ L +Y+
Sbjct: 670 TWPEKFGRGNSNMNHFFISDICS----GRLICDIANEMGQSLTPKCQSWDLSEMYQVTCE 725
Query: 285 KSKEKV--------YAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARL 336
K + + Y +++ L+ M A+V++ + + + QL L
Sbjct: 726 KEHKPLDIDYQNPQYQNDVNSMT---MALQENITNCMISAEVSYRI--QLLTLTKQLTNL 780
Query: 337 VGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES------------ 384
G + E+ LL + + P+K R ++ R++
Sbjct: 781 AGNAWAQTLGGTRAGRNEYILLHEFSRNGFIVPDKEGNRSRAQKQRQNEENADAPVNSKK 840
Query: 385 --YEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHR 441
Y+GG V EPEKGL + ++ +DF SLYPSII N+ T++R N ++ D P V
Sbjct: 841 AKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDR-NKEDIDELPSVPPS 899
Query: 442 FCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYA 501
G +P LL NL++ R+++KK MK DP ++ D RQ+A+K+ ANS YG GY
Sbjct: 900 EVDQ--GVLPRLLANLVDRRREVKKVMKTETDPHKRVQCDIRQQALKLTANSMYGCLGYV 957
Query: 502 KARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKAL 561
+R+Y K A VT GR+ + R+ ES V+Y DTD + + + + L
Sbjct: 958 NSRFYAKPLAMLVTNKGREILMNTRQLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGL 1017
Query: 562 KFVEYINSKLPGLLELEYEGFYARGFFVTKKKYAL----IDEEGKIVT----RGLEIVRR 613
F +N + LLE++ + + + KKKYA +D+ G T +GL++ RR
Sbjct: 1018 GFKRLVNERY-RLLEIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRR 1076
Query: 614 DWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTE----KLSKYEIPPEKLVIYEQITRP 669
++ ++++ VL IL + +EA++ V + E K+ I +K I ++++
Sbjct: 1077 EFCPLSRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKLSKD 1136
Query: 670 LSEYKA--IGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDG----------PISKRAIAI 717
Y P V VA R+ G VK G VI +++ + D +++RA A+
Sbjct: 1137 PKAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKQDEIDNAADTPALSVAERAHAL 1196
Query: 718 EEFDPKKHKY--DAEYYIENQVLPAVERIL 745
E K + D +YY+E Q+ VER+L
Sbjct: 1197 NEVMIKSNNLIPDPQYYLEKQIFAPVERLL 1226
>emb|CAB90776.1| (AL355632) dna polymerase zeta catalytic subunit [Schizosaccharomyces
pombe]
Length = 1480
Score = 178 bits (446), Expect = 3e-43
Identities = 160/641 (24%), Positives = 287/641 (43%), Gaps = 65/641 (10%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE-KLGIKLP--LGRDNS 237
V VV+SE E+I ++ + R+ DP ++ Y N + YL++RA + LP L R
Sbjct: 717 VLVVNSELELINEVIGLNRQLDPTIVCGYEVHNSSWGYLIERASYRFNYDLPEQLSRLKC 776
Query: 238 EPKMQ--------RMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
K + + ++ I GR +++ ++R +NL Y+LE V IF K
Sbjct: 777 TSKANFAKKENAWKYTTTSSINIVGRHVLNIWRILRGEVNLLNYSLENVVLNIFKKQTPY 836
Query: 290 VYAHEIAEAWETGKGLER--VAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVS 345
+ W++ + E+ + Y + + E+ + AR++G V
Sbjct: 837 YNQADKVHLWQSSRFHEKQILLNYMLNRTRYCLEILSACAIVTKIREQARIIGIDFMSVI 896
Query: 346 RSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSL 404
+ VE + R A N + P+ ++ E+ E+ V EP+ L+ +V L
Sbjct: 897 SRGSQFKVESIMFRIAKPENYIFPSPSAKQVAEQNALEALP--LVMEPKSDLYNNPVVVL 954
Query: 405 DFRSLYPSIIITHNVSPDTL----------------------NRENCKEYDV--APQVGH 440
DF+SLYPSIII +N+ T N N + DV +P G+
Sbjct: 955 DFQSLYPSIIIAYNLCYSTCLGPVKIVNGKVKLGFMFHSSNPNIVNLIKNDVYISPN-GY 1013
Query: 441 RFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYY 498
+ K+ + +L L+E R +K+ MK+ K+L+ RQ A+K++AN YGY
Sbjct: 1014 AYVKENVRKSLLAKMLEELIETRNMVKRGMKDCDSDYVNKVLNSRQLALKLIANVTYGYT 1073
Query: 499 GYA-KARWYCKECAESVTAWGRQYIDLVRRELESRGF---KVLYIDTDGLYATIPGAKHE 554
+ R C E A+++ GR+ + + + F KV+Y DTD L+ +PGA E
Sbjct: 1074 SASFSGRMPCSEIADTIVETGREILSYSLEYINTLDFCHAKVVYGDTDSLFVELPGATKE 1133
Query: 555 EIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV-TRGL 608
+ + + I S+ P + L++E Y F + KK+Y + ++ I +G+
Sbjct: 1134 QAFDIGQQLANNITSRFPSPIRLKFEKIYFPCFLLAKKRYVGFKFESVSQKAPIFEAKGI 1193
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITR 668
E VRRD + + ++ + LE + K ++ K + V ++ +P +++
Sbjct: 1194 ETVRRDGTPVQQQLLRRCLEILFKTKDLSTVKKEFQNVCYQIMSGNVPVMDFCFSKEVR- 1252
Query: 669 PLSEYKAIG---PHVAVAKRLAAKGVKVKP--GMVIGYIVLRG--DGPISKRAIAIEEF- 720
L +YK + P +A+RL K + +P G + Y+++ ++ R++A EEF
Sbjct: 1253 -LEKYKELSTAPPGAVMARRLMTKDPRREPQYGERVPYLIIAAAPGTTLANRSVAPEEFL 1311
Query: 721 DPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDLKYQKTK 761
+ D YYI N ++P ++R L G + ++ K
Sbjct: 1312 SSSFSQLDINYYINNSLIPPLDRFLNLLGASAQSWYHEMPK 1352
>gb|AAA34888.1| (J03268) polymerase I [Saccharomyces cerevisiae]
Length = 1468
Score = 176 bits (443), Expect = 6e-43
Identities = 164/630 (26%), Positives = 282/630 (44%), Gaps = 78/630 (12%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL---------- 230
V + ++E+ M+ +++ +DPDVII + N L R L I
Sbjct: 610 VRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAHRMHDLNIPTFSSIGRRLRR 669
Query: 231 ----PLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTIN--LPTYTLEAVYEAIFG 284
GR NS + D + GR+ D+ + +++ ++ L +Y+
Sbjct: 670 TWPEKFGRGNSNMNHFFISDICS----GRLICDIANEMGQSLTPKCQSWDLSEMYQVTCE 725
Query: 285 KSKEKV--------YAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARL 336
K + + Y +++ L+ + A+V++ + + + QL L
Sbjct: 726 KEHKPLDIDYQNPQYQNDVNSMT---MALQENITNCIVSAEVSYRI--QLLTLTKQLTNL 780
Query: 337 VGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES------------ 384
G + E+ LL + + P+K R ++ R++
Sbjct: 781 AGNAWAQTLGGTRAGRNEYILLHEFSRNGFIVPDKEGNRSRAQKQRQNEENADAPVNSKK 840
Query: 385 --YEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHR 441
Y+GG V EPEKGL + ++ +DF SLYPSII N+ T++R N ++ D P V
Sbjct: 841 AKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDR-NKEDIDELPSVPPS 899
Query: 442 FCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYA 501
G +P LL NL++ R+++KK MK DP ++ D RQ+A+K+ ANS YG GY
Sbjct: 900 EVDQ--GVLPRLLANLVDRRREVKKVMKTETDPHKRVQCDIRQQALKLTANSMYGCLGYV 957
Query: 502 KARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKAL 561
+R+Y K A VT GR+ + R+ ES V+Y DTD + + + + L
Sbjct: 958 NSRFYAKPLAMLVTNKGREILMNTRQLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGL 1017
Query: 562 KFVEYINSKLPGLLELEYEGFYARGFFVTKKKYAL----IDEEGKIVT----RGLEIVRR 613
F +N + LLE++ + + + KKKYA +D+ G T +GL++ RR
Sbjct: 1018 GFKRLVNERY-RLLEIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRR 1076
Query: 614 DWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTE----KLSKYEIPPEKLVIYEQITRP 669
++ ++++ VL IL + +EA++ V + E K+ I +K I ++++
Sbjct: 1077 EFCPLSRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKLSKD 1136
Query: 670 LSEYKA--IGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDG----------PISKRAIAI 717
Y P V VA R+ G VK G VI +++ + D +++RA A+
Sbjct: 1137 PKAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKQDEIDNAADTPALSVAERAHAL 1196
Query: 718 EEFDPKKHKY--DAEYYIENQVLPAVERIL 745
E K + D +YY+E Q+ VER+L
Sbjct: 1197 NEVMIKSNNLIPDPQYYLEKQIFAPVERLL 1226
>sp|P26019|DPOA_DROME DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|217344|dbj|BAA14340.1|
(D90310) DNA polymerase alpha [Drosophila melanogaster]
Length = 1505
Score = 175 bits (438), Expect = 2e-42
Identities = 161/607 (26%), Positives = 282/607 (45%), Gaps = 57/607 (9%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKM-QRM 244
SER ++ + ++ D D+I+T+ D+ D + + + +K+P ++ Q
Sbjct: 639 SERALLSWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSF 696
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE----KVYAHEIAEAWE 300
G L GR+ D+ I +Y L+ + + + K KE +V A ++ E +E
Sbjct: 697 GKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVL-KLKESERMEVNADDLLEMYE 755
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
G+ + ++ +M+D L E P+ Q+ + G + + E+ LL
Sbjct: 756 KGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLL 815
Query: 359 RKAYERNELAPNKPD-----------------EREYERRLRESYEGGYVKEPEKGLWEGI 401
+ E+N + P+K + + + + +Y GG V EP +GL+E
Sbjct: 816 HASTEKNYIVPDKKPVSKRSGAGDTDRTLSGADATMQTKKKAAYAGGLVLEPMRGLYEKY 875
Query: 402 VSL-DFRSLYPSIIITHNVSPDTLNRE-NCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLE 459
V L D SLYPSII +N+ + + + + E P K PG +P L L+E
Sbjct: 876 VLLMDLNSLYPSIIQEYNICFNPVQQPVDADELPTLPD-----SKTEPGILPLQLKRLVE 930
Query: 460 ERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWG 518
R+++KK M P + RQ A+K+ ANS YG G+A +R++ + A VT G
Sbjct: 931 SRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKG 990
Query: 519 RQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELE 578
R + ++ ++ + V+Y DTD L ++++ + + +N KL LEL+
Sbjct: 991 RDLTN-TQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVN-KLYKQLELD 1048
Query: 579 YEGFYARGFFVTKKKYALI----DEEGKI----VTRGLEIVRRDWSEIAKETQAKVLEAI 630
+G + + KKKYA I D +G + +GL+IVRRDWS++A VL+ +
Sbjct: 1049 IDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEV 1108
Query: 631 LKHGNVDEAVKIVKEVTEK----LSKYEIPPEKLVIYEQITRPLSEYK--AIGPHVAVAK 684
L ++E + V EK +++ +P VI +Q+TR +Y+ A PHV VA
Sbjct: 1109 LSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQDYRNSASLPHVQVAL 1168
Query: 685 RL-AAKGVKVKPGMVIGYI-VLRG-DGPISKRAIAIEEF---DPKKHKYDAEYYIENQVL 738
R+ + + K G ++ L G +RA ++E + KK + D YY+ +Q+
Sbjct: 1169 RMNRERNRRYKKGDMVDLCDCLDGTTNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQIH 1228
Query: 739 PAVERIL 745
P V R++
Sbjct: 1229 PVVTRMV 1235
>dbj|BAA32745.1| (AB011813) DNA polymerase alpha 180K subunit [Drosophila
melanogaster]
Length = 1415
Score = 175 bits (438), Expect = 2e-42
Identities = 161/607 (26%), Positives = 282/607 (45%), Gaps = 57/607 (9%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKM-QRM 244
SER ++ + ++ D D+I+T+ D+ D + + + +K+P ++ Q
Sbjct: 639 SERALLSWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSF 696
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE----KVYAHEIAEAWE 300
G L GR+ D+ I +Y L+ + + + K KE +V A ++ E +E
Sbjct: 697 GKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVL-KLKESERMEVNADDLLEMYE 755
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
G+ + ++ +M+D L E P+ Q+ + G + + E+ LL
Sbjct: 756 KGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLL 815
Query: 359 RKAYERNELAPNKPD-----------------EREYERRLRESYEGGYVKEPEKGLWEGI 401
+ E+N + P+K + + + + +Y GG V EP +GL+E
Sbjct: 816 HASTEKNYIVPDKKPVSKRSGAGDTDRTLSGADATMQTKKKAAYAGGLVLEPMRGLYEKY 875
Query: 402 VSL-DFRSLYPSIIITHNVSPDTLNRE-NCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLE 459
V L D SLYPSII +N+ + + + + E P K PG +P L L+E
Sbjct: 876 VLLMDLNSLYPSIIQEYNICFNPVQQPVDADELPTLPD-----SKTEPGILPLQLKRLVE 930
Query: 460 ERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWG 518
R+++KK M P + RQ A+K+ ANS YG G+A +R++ + A VT G
Sbjct: 931 SRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKG 990
Query: 519 RQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELE 578
R + ++ ++ + V+Y DTD L ++++ + + +N KL LEL+
Sbjct: 991 RDLTN-TQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVN-KLYKQLELD 1048
Query: 579 YEGFYARGFFVTKKKYALI----DEEGKI----VTRGLEIVRRDWSEIAKETQAKVLEAI 630
+G + + KKKYA I D +G + +GL+IVRRDWS++A VL+ +
Sbjct: 1049 IDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEV 1108
Query: 631 LKHGNVDEAVKIVKEVTEK----LSKYEIPPEKLVIYEQITRPLSEYK--AIGPHVAVAK 684
L ++E + V EK +++ +P VI +Q+TR +Y+ A PHV VA
Sbjct: 1109 LSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQDYRNSASLPHVQVAL 1168
Query: 685 RL-AAKGVKVKPGMVIGYI-VLRG-DGPISKRAIAIEEF---DPKKHKYDAEYYIENQVL 738
R+ + + K G ++ L G +RA ++E + KK + D YY+ +Q+
Sbjct: 1169 RMNRERNRRYKKGDMVDLCDCLDGTTNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQIH 1228
Query: 739 PAVERIL 745
P V R++
Sbjct: 1229 PVVTRMV 1235
>gb|AAA81882.1| (U00429) DNA polymerase [Pyrococcus sp. GI-J]
Length = 96
Score = 171 bits (430), Expect = 2e-41
Identities = 81/96 (84%), Positives = 89/96 (92%), Gaps = 1/96 (1%)
Query: 462 QKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQY 521
Q+IK++MK SKDP+EKK LDYRQRAIKILANSYYGYYG AKARWYCKECAESVTAWGR+Y
Sbjct: 1 QEIKRKMKASKDPIEKKKLDYRQRAIKILANSYYGYYGSAKARWYCKECAESVTAWGREY 60
Query: 522 IDLVRRELESR-GFKVLYIDTDGLYATIPGAKHEEI 556
I+ VR+ELE + GFKVLYIDTDGLYATIPGAK EEI
Sbjct: 61 IEFVRKELEEKFGFKVLYIDTDGLYATIPGAKPEEI 96
>pir||E82227 DNA polymerase II VC1212 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9655692|gb|AAF94371.1| (AE004201) DNA
polymerase II [Vibrio cholerae]
Length = 787
Score = 171 bits (429), Expect = 3e-41
Identities = 195/775 (25%), Positives = 345/775 (44%), Gaps = 105/775 (13%)
Query: 44 DDSAIDEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIREKIREH 103
+ SA EV +I AE + + + F G+P+ Y +D + EK+ +
Sbjct: 47 EQSASQEVMRIAAELS---ITPSLAPLSLRSFAGQPLAA--CYCNTIRDSQILAEKLAQ- 100
Query: 104 PAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDI-------ETLYHEGEEFGKGP 156
A + I E DI A R+L+++ + +G+ E T D + +G+
Sbjct: 101 -ADMLILEADIRLADRFLMERFI---QGSIEFTGQITDFGHYRQVQQAKCRQGDYLPT-- 154
Query: 157 IIMISYADEEGAKVITWK-SIDLPY----------------VEVVSSEREMIKRLVKVIR 199
+ M+S E K + + +D P ++ V E +++K L+
Sbjct: 155 LNMVSLDIECSEKGLLYSIGLDSPMDSRVIMIGQPEPAETPIQWVEDEYQLLKALIAWFE 214
Query: 200 EKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLA---VEIKGRI 256
+ DPDVII ++ +FDF L KRAE +KL +GR +P R + I GR+
Sbjct: 215 QFDPDVIIGWSVVDFDFRLLHKRAEFHKLKLTIGRAQ-QPSFFRTASQTQQGFISIPGRV 273
Query: 257 HFDLFPVIRR-TINLPTYTLEAVYEAIFGKSKEKVYAH----EIAEAWETGKGLERVAKY 311
D ++ T + +++LE+V + + G+ K H EI + + K +A+Y
Sbjct: 274 VLDGIDTLKTATYHFRSWSLESVSQELLGEGKAIHNVHDRMDEINQMFRHDK--PSLARY 331
Query: 312 SMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFL---LRKAYERNE 366
+++D + ++ Q +RL G V G V F L + +
Sbjct: 332 NLQDCVLVNKIFAATHLLDFAIQRSRLTG-----VELDRIGGSVAAFTNLYLPQLHRAGY 386
Query: 367 LAPNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNR 426
+APN E + GGYV + GL++ ++ LDF+SLYPSII + + P L
Sbjct: 387 VAPNLQPENWV------ASPGGYVMDSIPGLYDSVLVLDFKSLYPSIIRSFLIDP--LGL 438
Query: 427 ENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRA 486
+ + Q H PGF ++ +++ ++D ++ +A
Sbjct: 439 IEGLKLPIGKQADHAV----PGFRGGQFHRTKHFLPEMIEKLWAARDEAKRNQEKAFSQA 494
Query: 487 IKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYA 546
IKI+ NS+YG G + R++ A S+T G + + +R +E+RG++V+Y DTD +
Sbjct: 495 IKIIMNSFYGVLGSSGCRFFDARLASSITMRGHEIMIQTKRLIEARGYQVIYGDTDSTFV 554
Query: 547 TIPG---------AKHEEIKEKALKFVEYINSK--LPGLLELEYEGFYARGFFVT----- 590
+ G H ++E + E++ + L +LELEYE Y R T
Sbjct: 555 ALGGQYSQQEADNIGHALVREINQWWTEHLKQEYALTSILELEYETHYRRFLMPTIRGSE 614
Query: 591 ---KKKYALIDEEG---KIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVK 644
KK+YA + +G +++ +GLE R DW+ +A+ Q ++ + I HG E+ ++
Sbjct: 615 TGSKKRYAGLKGDGDNEQLIFKGLESARTDWTPLAQRFQHQLYQLIF-HGQDPES--YIR 671
Query: 645 EVTEKLSKYEIPPEKLVIYEQITRPLSEY-KAIGPHVAVAKRLAAKGVKVKPGMVIGYIV 703
+ E+ ++ ++LV +++ R L EY K + P V A+ A + K G + Y
Sbjct: 672 TIVEQTLAGQL-DDQLVYQKRLRRRLHEYQKNVPPQVRAAR--MADDINAKLGRPLQY-Q 727
Query: 704 LRGDGPISKRAIAIEEFDPK---KHKYDAEYYIENQVLPAVERILRAFGYRKEDL 755
RG + I + +PK K D ++YI+ Q+ P + IL G + ++L
Sbjct: 728 YRG---TIEYVITVNGPEPKEYSKSPIDYQHYIDKQLKPVADAILPFIGKQFDEL 779
>sp|O00874|DPOA_LEIDO DNA POLYMERASE ALPHA CATALYTIC SUBUNIT >gi|7434794|pir||JC5508
DNA-directed DNA polymerase (EC 2.7.7.7) alpha catalytic
chain - Leishmania donovani >gi|2138288|gb|AAC47538.1|
(U78172) DNA polymerase alpha catalytic subunit
[Leishmania donovani]
Length = 1339
Score = 170 bits (427), Expect = 4e-41
Identities = 168/651 (25%), Positives = 303/651 (45%), Gaps = 83/651 (12%)
Query: 156 PIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFD 215
PI + SY +G LP V ++ER ++ L + + + D D++I +N F
Sbjct: 488 PIDLESYCSAKG----------LPGVRRFANERALLDWLAQQLGKIDADMMIGHNFLGFT 537
Query: 216 FPYLLKRAEKLGIKL--PLGRDNSE--PKMQRMGDSLAVEIK---GRIHFDLFPVIRRTI 268
LL+R ++L I +GR + + P+ Q ++ E + GR+ D + + R
Sbjct: 538 LDILLRRYQELSISSWSTIGRLDLKRLPRFQGTATNVNQEKETCIGRLVVDSYSLSREHY 597
Query: 269 NLPTYTLEAVYEAI-----------FGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAK 317
Y L ++ + + F + ++ + + L +V ++
Sbjct: 598 KTVNYRLLSLADQMQLQGITKGSNNFEPGTSVLTPAMLSASRDIYDVLLQVCNCAVLSTA 657
Query: 318 VTFELGKEFFPMEAQLARLVGQPVWDVSRSSTG---NLVEWFLLRKAYERNELAPNK--- 371
V L + + +L + G +W SR+ G +E+ LL ++ + P++
Sbjct: 658 VVSHL--DVIRLTKRLTTIAGN-LW--SRTLFGARSERIEYLLLHTFHDLKFITPDRYVQ 712
Query: 372 ------PDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTL 424
DE E + + + Y+GG V +P+ GL+ I+ LDF SLYPS+I N+ T+
Sbjct: 713 NFKRGRDDEEEEDGKRKAKYQGGMVLDPKCGLYSDYILLLDFNSLYPSLIQEFNICFTTV 772
Query: 425 NRENCKEYDVAPQVGHRFCKDFPG-----------FIPSLLGNLLEERQKIKKRMKESKD 473
+RE+ E DV P + C +P ++ +L++ R+++K+ MK KD
Sbjct: 773 DRESGSEIDVPPPE-NLICASCAAAGLSAPCLHKCVLPKVIKSLVDSRREVKRLMKIEKD 831
Query: 474 PVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGR----QYIDLVRREL 529
LL+ RQ+A+K+ ANS YG G+ +R++ + AE VT GR +DL+ +
Sbjct: 832 ANNLALLEIRQKALKLTANSMYGCLGFEYSRFHAQPLAELVTRQGRLALQSTVDLIPQLN 891
Query: 530 ESRGFKVLYIDTDGLYATIPGAKHE--EIKEKALKFVEYINSKLPGLLELEYEGFYARGF 587
S +V+Y DTD + G K++ +++ L IN + LE++ +G +
Sbjct: 892 PS--LRVIYGDTDSVMIQ-TGIKNDIKAVRDLGLDLKAKINKRYQS-LEIDIDGVFRAIL 947
Query: 588 FVTKKKYALI-----DEEGKIV---TRGLEIVRRDWSEIAK----ETQAKVLEAILKHGN 635
+ KKKYA + EGK +GL++VRRDW ++K ++VL A
Sbjct: 948 LLKKKKYAALTVTDWQGEGKTYKKEVKGLDMVRRDWCPLSKCVCDSVLSRVLNAEGSEDI 1007
Query: 636 VDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKVK 694
+D + +++V+EK+ + VI + +T+ Y+ PH VA R+ + V+
Sbjct: 1008 LDYVMNYMRDVSEKVRAGRYTLDNFVISKSLTKEPEAYRGNSFPHATVALRMKQRKELVR 1067
Query: 695 PGMVIGYIVLRGDGPISKRAIAIEEFDPKKH-KYDAEYYIENQVLPAVERI 744
G +I Y++ GD +S +A +EE + D+E+Y+ Q+ P V R+
Sbjct: 1068 VGDLIPYVICTGD-RLSDKAFHVEEVRQNSQLQIDSEWYLSVQIYPPVMRL 1117
>gi|9631753 PBVC-1 DNA polymerase [Paramecium bursaria Chlorella virus 1]
>gi|3915670|sp|P30321|DPOL_CHVP1 DNA POLYMERASE
>gi|7434804|pir||T17675 DNA-directed DNA polymerase (EC
2.7.7.7) - Chlorella virus PBCV-1
>gi|1181348|gb|AAC96553.1| (U42580) PBVC-1 DNA
polymerase [Paramecium bursaria Chlorella virus 1]
>gi|2702251|gb|AAC00532.1| (M86836) DNA polymerase
[Paramecium bursaria Chlorella virus 1]
Length = 913
Score = 169 bits (424), Expect = 1e-40
Identities = 183/661 (27%), Positives = 315/661 (46%), Gaps = 95/661 (14%)
Query: 181 VEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSE 238
VE++S E +++ +K+++++ DV I YN +D Y+ R + + + G D +
Sbjct: 241 VEIISCLEESDVMNTWMKILQDEKTDVSIGYNTWQYDLRYVHGRTQ-MCVDDMTGED--K 297
Query: 239 PKMQRMGDSLA----------------------VEIKGRIHFDLFPVIRRTINLPTYTLE 276
K+ +G L+ +++ G + DL R+ NL +Y+L
Sbjct: 298 VKLSNLGRLLSGGGEVVERDLSSNAFGQNKFFLLDMPGVMQIDLLQWFRKNRNLESYSLN 357
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETGKGLER--VAKYSMEDAKVTFELGKEFFPME--AQ 332
V + G K + A +I E +E G +R +A Y+ +D + +L K+ +E +
Sbjct: 358 NVSKLYLGDQKNDLPAMQIFEKFE-GNAEDRAIIAAYAAKDTDLPLKLLKKMAILEDLTE 416
Query: 333 LARLVGQPVWDVSRSSTGNLVEWF--LLRKAYERNELAPNKPDEREYERRLRESYEGGYV 390
+A V PV ++ G + F L+ KA + N P D++ + + YEG V
Sbjct: 417 MANAVKVPVDYIN--FRGQQIRAFSCLVGKARQMNYAIP---DDKAWATEGK--YEGATV 469
Query: 391 KEPEKGLW-EGIVSLDFRSLYPSIIITHNVSPDTLNRENCKE-------YDVAPQVGH-R 441
+ +KG + I +LDF SLYPSII HN+SP+TL E E Y++ +G +
Sbjct: 470 LDAKKGAYFTPIAALDFASLYPSIIRAHNMSPETLVMEKRFENVPGVEYYEIETGLGKFK 529
Query: 442 FCK------DFPGFIPSLLGNLLEERQKIKKRMKESK---DPVEKKLLDYRQRAIKILAN 492
+ + + G +P+LL +L + R+ KK M E+K D ++ L D +QR+ K++ N
Sbjct: 530 YAQKNDETGEGQGVVPALLDDLAKFRKLAKKHMAEAKRNGDDFKEALYDAQQRSFKVVMN 589
Query: 493 SYYGYYGYAKARWYCKECAESVTAWGRQYID-LVRRELE-SRGFKVLYIDTDGLYA--TI 548
S YG+ G +K C A SVTA GR+ I+ +R +E G +V+Y DTD + +
Sbjct: 590 SVYGFLGASKGFIPCVPIAASVTATGRKMIEHTAKRAVELLPGSEVIYGDTDSVMVKMKL 649
Query: 549 PGAKHEEIKEKALKFVEYINSKLP----GLLELEYEGFYARGFFVTKKKYALI-----DE 599
P K ++ E+ K +++ ++ +LE+E Y +KK+YA + DE
Sbjct: 650 PDDKVHDMDEQ-FKMAKWLAGEITKDFRAPNDLEFEKIYYPYILYSKKRYAAVKFEEPDE 708
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
+GK+ +GL +VRRD+S I ++ + L+ IL + AV E K+ E P EK
Sbjct: 709 KGKVDVKGLALVRRDFSPITRDILKESLDTILYKKDTPTAVSETLERIRKVLDNEYPMEK 768
Query: 660 LVIYEQITRPLSEYK-AIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRG-DGPISKRAIA 716
++ + + + YK PH+ VA ++ + G V G + ++ + P K++
Sbjct: 769 FMMSKLLK---TGYKNECQPHLHVANKIYERTGFPVPSGARVPFVYIEDKKNPDIKQSFK 825
Query: 717 IEEFDPKKHK-----YDAEYYIENQVLPAV----ERIL-----RAFGYRKEDLKYQKTKQ 762
E DP + D +YIE+Q+L + E +L FG+R K + K
Sbjct: 826 AE--DPTFAQDNGLIVDRLFYIEHQLLKPICSLFEPLLDDPEKEIFGHRLIKEKIENLKN 883
Query: 763 V 763
V
Sbjct: 884 V 884
>gb|AAB94881.1| (AF028831) DNA polymerase [Cenarchaeum symbiosum]
Length = 842
Score = 169 bits (423), Expect = 1e-40
Identities = 178/644 (27%), Positives = 278/644 (42%), Gaps = 69/644 (10%)
Query: 95 AIREKIREHPAV-VDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFG 153
A R++ RE A D+ IP +R D + EG ++ T G
Sbjct: 171 ADRKEFREFIAGWADLLNQPIPRIRRLSFDIEVDSEEGRIPDPKISDRRVTAVGFAATDG 230
Query: 154 KGPIIMISYADEEGAKVITWKSIDLPYVEVV--SSEREMIKRLVKVIREKDPDVIITYNG 211
+ ++ EEG +T P VEVV E +MI+ + VI ++TYNG
Sbjct: 231 LKQVFVLRSGAEEGENGVT------PGVEVVFYDKEADMIRDALSVIGSYP--FVLTYNG 282
Query: 212 DNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVI-RRTINL 270
D+FD PY+L RA +LG+ +S+ + M DS ++ +H DL+ R+ L
Sbjct: 283 DDFDMPYMLNRARRLGVS------DSDIPLYMMRDSAT--LRHGVHLDLYRTFSNRSFQL 334
Query: 271 -------PTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL- 322
Y+L +V +A+ G+ K Y ++ + L + A Y DA++T EL
Sbjct: 335 YAFAAKYTDYSLNSVTKAMLGEGKVD-YGVKLGDLT-----LYQTANYCYHDARLTLELS 388
Query: 323 --GKEFF-PMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYER 379
G E + +R+ P+ D+SR + L + +RN L P + E E
Sbjct: 389 TFGNEILMDLLVVTSRIARMPIDDMSRMGVSQWIRSLLYYEHRQRNALIPRRD---ELEG 445
Query: 380 RLRE----------SYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLN--RE 427
R RE + GG V EPE+G+ + +DF SLYPSII N+S +T+
Sbjct: 446 RSREVSNDAVIKDKKFRGGLVVEPEEGIHFDVTVMDFASLYPSIIKVRNLSYETVRCVHA 505
Query: 428 NCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYR--QR 485
CK+ + P H C G ++G+L + R K + +S E++ Y +
Sbjct: 506 ECKK-NTIPDTNHWVCTKNNGLTSMIIGSLRDLRVNYYKSLSKSTSITEEQRQQYTVISQ 564
Query: 486 AIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLY 545
A+K++ N+ YG G Y AE+ TA GR I E G +VLY DTD L+
Sbjct: 565 ALKVVLNASYGVMGAEIFPLYFLPAAEATTAVGRYIIMQTISHCEQMGVRVLYGDTDSLF 624
Query: 546 ATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVT 605
P + +I E VE+ + LE++ E Y KK Y + GK+
Sbjct: 625 IKDP--EERQIHE----IVEHAKKEHGVELEVDKEYRYV-VLSNRKKNYFGVTRAGKVDV 677
Query: 606 RGLEIVRRDWSEIAKETQAKVLEAILKHGNVDE----AVKIVKEVT---EKLSKYEIPPE 658
+GL + KE +L+ + + DE ++I K + ++L + +IP
Sbjct: 678 KGLTGKKSHTPPFIKELFYSLLDILSGVESEDEFESAKMRISKAIAACGKRLEERQIPLV 737
Query: 659 KLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYI 702
L I++ SEY P A RL +VK G +I Y+
Sbjct: 738 DLAFNVMISKAPSEYVKTVPQHIRAARLLENAREVKKGDIISYV 781
>pir||T31321 DNA-directed DNA polymerase (EC 2.7.7.7) B - Cenarchaeum symbiosum
>gi|3599407|gb|AAC62712.1| (AF083072) archael family B
DNA polymerase B [Cenarchaeum symbiosum]
Length = 844
Score = 169 bits (423), Expect = 1e-40
Identities = 178/644 (27%), Positives = 278/644 (42%), Gaps = 69/644 (10%)
Query: 95 AIREKIREHPAV-VDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFG 153
A R++ RE A D+ IP +R D + EG ++ T G
Sbjct: 173 ADRKEFREFIAGWADLLNQPIPRIRRLSFDIEVDSEEGRIPDPKISDRRVTAVGFAATDG 232
Query: 154 KGPIIMISYADEEGAKVITWKSIDLPYVEVV--SSEREMIKRLVKVIREKDPDVIITYNG 211
+ ++ EEG +T P VEVV E +MI+ + VI ++TYNG
Sbjct: 233 LKQVFVLRSGAEEGENGVT------PGVEVVFYDKEADMIRDALSVIGSYP--FVLTYNG 284
Query: 212 DNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVI-RRTINL 270
D+FD PY+L RA +LG+ +S+ + M DS ++ +H DL+ R+ L
Sbjct: 285 DDFDMPYMLNRARRLGVS------DSDIPLYMMRDSAT--LRHGVHLDLYRTFSNRSFQL 336
Query: 271 -------PTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL- 322
Y+L +V +A+ G+ K Y ++ + L + A Y DA++T EL
Sbjct: 337 YAFAAKYTDYSLNSVTKAMLGEGKVD-YGVKLGDLT-----LYQTANYCYHDARLTLELS 390
Query: 323 --GKEFF-PMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYER 379
G E + +R+ P+ D+SR + L + +RN L P + E E
Sbjct: 391 TFGNEILMDLLVVTSRIARMPIDDMSRMGVSQWIRSLLYYEHRQRNALIPRRD---ELEG 447
Query: 380 RLRE----------SYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLN--RE 427
R RE + GG V EPE+G+ + +DF SLYPSII N+S +T+
Sbjct: 448 RSREVSNDAVIKDKKFRGGLVVEPEEGIHFDVTVMDFASLYPSIIKVRNLSYETVRCVHA 507
Query: 428 NCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYR--QR 485
CK+ + P H C G ++G+L + R K + +S E++ Y +
Sbjct: 508 ECKK-NTIPDTNHWVCTKNNGLTSMIIGSLRDLRVNYYKSLSKSTSITEEQRQQYTVISQ 566
Query: 486 AIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLY 545
A+K++ N+ YG G Y AE+ TA GR I E G +VLY DTD L+
Sbjct: 567 ALKVVLNASYGVMGAEIFPLYFLPAAEATTAVGRYIIMQTISHCEQMGVRVLYGDTDSLF 626
Query: 546 ATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVT 605
P + +I E VE+ + LE++ E Y KK Y + GK+
Sbjct: 627 IKDP--EERQIHE----IVEHAKKEHGVELEVDKEYRYV-VLSNRKKNYFGVTRAGKVDV 679
Query: 606 RGLEIVRRDWSEIAKETQAKVLEAILKHGNVDE----AVKIVKEVT---EKLSKYEIPPE 658
+GL + KE +L+ + + DE ++I K + ++L + +IP
Sbjct: 680 KGLTGKKSHTPPFIKELFYSLLDILSGVESEDEFESAKMRISKAIAACGKRLEERQIPLV 739
Query: 659 KLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYI 702
L I++ SEY P A RL +VK G +I Y+
Sbjct: 740 DLAFNVMISKAPSEYVKTVPQHIRAARLLENAREVKKGDIISYV 783
>dbj|BAA35142.1| (AB011500) DNA polymerase [Chlorella virus K2]
Length = 913
Score = 168 bits (422), Expect = 2e-40
Identities = 175/626 (27%), Positives = 301/626 (47%), Gaps = 86/626 (13%)
Query: 181 VEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSE 238
VE++S E +++ +K+++++ DV I YN +D Y+ R + + + G D +
Sbjct: 241 VEIISCLEESDVMNTWMKILQDEKTDVSIGYNTWQYDLRYVHGRTQ-MCVDDMTGED--K 297
Query: 239 PKMQRMGDSLA----------------------VEIKGRIHFDLFPVIRRTINLPTYTLE 276
K+ +G L+ +++ G + DL R+ NL +Y+L
Sbjct: 298 VKLSNLGRLLSGGGEVVERDLSSNAFGQNKFFLLDMPGVMQIDLLQWFRKNRNLESYSLN 357
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETGKGLER--VAKYSMEDAKVTFELGKEFFPME--AQ 332
V + G K + A +I E +E G +R +A Y+ +D + +L K+ +E +
Sbjct: 358 NVSKLYLGDQKNDLPAMQIFEKFE-GDSEDRAVIAAYAAKDTDLPLKLLKKMAILEDLTE 416
Query: 333 LARLVGQPVWDVSRSSTGNLVEWF--LLRKAYERNELAPNKPDEREYERRLRESYEGGYV 390
+A V PV ++ G + F L+ KA + N P D++ + + YEG V
Sbjct: 417 MANAVKVPVDYIN--FRGQQIRAFSCLVGKARQMNYAIP---DDKAWATEGK--YEGATV 469
Query: 391 KEPEKGLW-EGIVSLDFRSLYPSIIITHNVSPDTLNRENCKE-------YDVAPQVGH-R 441
+ +KG + I +LDF SLYPSII HN+SP+TL E E Y++ +G +
Sbjct: 470 LDAKKGAYFTPIAALDFASLYPSIIRAHNMSPETLVMEKRFENVPGVEYYEIETGLGKFK 529
Query: 442 FCK------DFPGFIPSLLGNLLEERQKIKKRMKESK---DPVEKKLLDYRQRAIKILAN 492
+ + + G +P+LL +L + R+ KK M E+K D ++ L D +QR+ K++ N
Sbjct: 530 YAQKNDETGEGQGVVPALLDDLAKFRKLAKKHMAEAKRNGDDFKEALYDAQQRSFKVVMN 589
Query: 493 SYYGYYGYAKARWYCKECAESVTAWGRQYID-LVRRELE-SRGFKVLYIDTDGLYA--TI 548
S YG+ G +K C A SVTA GR+ I+ +R +E G +V+Y DTD + +
Sbjct: 590 SVYGFLGASKGFIPCVPIAASVTATGRKMIEHTAKRAVELLPGSEVIYGDTDSVMVKMKL 649
Query: 549 PGAKHEEIKEKALKFVEYINSKLP----GLLELEYEGFYARGFFVTKKKYALI-----DE 599
P K ++ E+ K +++ ++ +LE+E Y +KK+YA + DE
Sbjct: 650 PDDKVHDMDEQ-FKMAKWLAGEITKDFRAPNDLEFEKIYYPYILYSKKRYAAVKFEEPDE 708
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
GK+ +GL +VRRD+S I +E + L+ IL + AV E K+ E P EK
Sbjct: 709 TGKVDVKGLALVRRDFSPITREILKESLDTILYKKDTPTAVSETLERIRKVLDNEYPMEK 768
Query: 660 LVIYEQITRPLSEYK-AIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRG-DGPISKRAIA 716
++ + + + YK PH+ VA ++ + G V G + ++ + P K++
Sbjct: 769 FMMSKTLK---TGYKNECQPHLTVANKIYERTGFPVPSGARVPFVYIEDKKNPDIKQSFK 825
Query: 717 IEEFDPKKHK-----YDAEYYIENQV 737
E DP + D +YIE+Q+
Sbjct: 826 AE--DPTFARDNDLVVDRLFYIEHQL 849
>gi|9625657 BALF5 DNA polymerase (early), homologous to many DNA polymerases,
CMV HFLF2 and RF 28 VZV. 4.5kb early RNA apparently
encodes BALF5, RNA ends unknown. [Human herpesvirus 4]
>gi|118858|sp|P03198|DPOL_EBV DNA POLYMERASE
>gi|67032|pir||DJBE2L DNA-directed DNA polymerase (EC
2.7.7.7) - human herpesvirus 4 (strain B95-8)
>gi|1334913|emb|CAA24805.1| (V01555) BALF5 DNA
polymerase (early), homologous to many DNA polymerases,
CMV HFLF2 and RF 28 VZV. 4.5kb early RNA apparently
encodes BALF5, RNA ends unknown. [Human herpesvirus 4]
Length = 1015
Score = 166 bits (417), Expect = 7e-40
Identities = 165/646 (25%), Positives = 279/646 (42%), Gaps = 105/646 (16%)
Query: 128 PMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS-- 185
P NE L + L+ GEE G+ I+++ E D+ VEV
Sbjct: 306 PTATNEADLILQISC-VLWSTGEEAGRYRRILLTLGTCE----------DIEGVEVYEFP 354
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLG----RDNSEPKM 241
SE +M+ ++IR+ +++ YN NFD+PY+L RA + P R ++
Sbjct: 355 SELDMLYAFFQLIRDLSVEIVTGYNVANFDWPYILDRARHIYSINPASLGKIRAGGVCEV 414
Query: 242 QRMGDS--------LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAH 293
+R D+ V I G I D++ V R ++L Y L+ V + G KE V+
Sbjct: 415 RRPHDAGKGFLRANTKVRITGLIPIDMYAVCRDKLSLSDYKLDTVARHLLGAKKEDVHYK 474
Query: 294 EIAEAWETG-KGLERVAKYSMEDAKVTFELGKEFF--PMEAQLARLVGQPVWDVSRSSTG 350
EI + G +G R+ Y ++D+ + +L F A++A++ P V
Sbjct: 475 EIPRLFAAGPEGRRRLGMYCVQDSALVMDLLNHFVIHVEVAEIAKIAHIPCRRVLDDGQQ 534
Query: 351 NLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSL 409
V LL A + N + P P + R+ Y+G V +P G + ++ +DF SL
Sbjct: 535 IRVFSCLLAAAQKENFILP-MPSASD-----RDGYQGATVIQPLSGFYNSPVLVVDFASL 588
Query: 410 YPSIIITHN------VSPDTLNR-------ENCKEYDVAPQVGHRFCKDF-PGFIPSLLG 455
YPSII HN ++P +R E+ + + + V H K F+ SLL
Sbjct: 589 YPSIIQAHNLCYSTMITPGEEHRLAGLRPGEDYESFRLTGGVYHFVKKHVHESFLASLLT 648
Query: 456 NLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVT 515
+ L +R+ IKK + +DP ++ +LD +Q AIK N+ YG+ G A + C AE+VT
Sbjct: 649 SWLAKRKAIKKLLAACEDPRQRTILDKQQLAIKCTCNAVYGFTGVANGLFPCLSIAETVT 708
Query: 516 AWGRQYIDLVRRELESRG----------------------FKVLYIDTDGLYATIPGAKH 553
GR ++ + +E+ +V+Y DTD L+ G
Sbjct: 709 LQGRTMLERAKAFVEALSPANLQALAPSPDAWAPLNPEGQLRVIYGDTDSLFIECRGFSE 768
Query: 554 EEIKEKALKFVEYI-----NSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGL 608
E L+F + + S + LE E ++ +TKK+Y + +GK + +G+
Sbjct: 769 SE----TLRFADALAAHTTRSLFVAPISLEAEKTFSCLMLITKKRYVGVLTDGKTLMKGV 824
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEA------------------------VKIVK 644
E+VR+ + + +VL+ +L V EA + I+
Sbjct: 825 ELVRKTACKFVQTRCRRVLDLVLADARVKEAASLLSHRPFQESFTQGLPVGFLPVIDILN 884
Query: 645 EVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAK 689
+ L + +P +L +++R LS YK+ PH+AV ++ +
Sbjct: 885 QAYTDLREGRVPMGELCFSTELSRKLSAYKSTQMPHLAVYQKFVER 930
>gb|AAC62689.1| (AF083071) archael family B DNA polymerase [Cenarchaeum symbiosum]
Length = 845
Score = 166 bits (416), Expect = 9e-40
Identities = 170/643 (26%), Positives = 279/643 (42%), Gaps = 65/643 (10%)
Query: 95 AIREKIREHPAV-VDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFG 153
A R++ RE A D+ IP +R D + EG ++ T G
Sbjct: 172 ADRKEFREFIAGWADLLNQPIPRIRRLSFDIEVDSEEGRIPDAKISDRRVTAVGFAATDG 231
Query: 154 KGPIIMISYADEEGAKVITWKSIDLPYVEVV----SSEREMIKRLVKVIREKDPDVIITY 209
++++ +EGA +T P VEVV E +MI+ + +I ++TY
Sbjct: 232 LRKVLVLKSGADEGANDVT------PGVEVVFYDEDKEADMIRDALAIIGSYP--FVLTY 283
Query: 210 NGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVI-RRTI 268
NGD+FD PY+ RA +LG+ +S+ + M DS ++ +H DL+ R+
Sbjct: 284 NGDDFDMPYMYNRARRLGVA------DSDIPLYMMRDSAT--LRHGVHLDLYRTFSNRSF 335
Query: 269 NL-------PTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFE 321
L Y+L +V +A+ G+ K Y + + L + A Y DA++T E
Sbjct: 336 QLYAFAAKYTDYSLNSVSKAMLGEGKVD-YGVSLGDLT-----LYQTANYCYHDARLTLE 389
Query: 322 L---GKEFF-PMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREY 377
L G E + +R+ P+ D+SR + L + +RN L P + + +
Sbjct: 390 LSTFGNEILMDLLVVTSRIARMPIDDMSRMGVSQWIRSLLYYEHRQRNALIPRRDELEKR 449
Query: 378 ERRLR-------ESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLN--REN 428
+++ + + GG V EPE+G+ + +DF SLYPSII N+S +T+
Sbjct: 450 SQQVSNDAVIKDKKFRGGLVVEPEEGIHFDVTVMDFASLYPSIIKVRNLSYETVRCVHPE 509
Query: 429 CKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYR--QRA 486
C++ + P H C G ++G+L + R K + +S+ E++ Y +A
Sbjct: 510 CRK-NTIPDTNHWVCTKNNGLTSMIIGSLRDLRVNYYKSLSKSQSITEEQRQQYTVISQA 568
Query: 487 IKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYA 546
+K++ N+ YG G Y AE+ TA GR I E G KVLY DTD L+
Sbjct: 569 LKVVLNASYGVMGAEIFPLYFLPAAEATTAVGRYIIMQTISHCEQMGVKVLYGDTDSLF- 627
Query: 547 TIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTR 606
I + +I + VE+ + LE++ E Y KK Y + + GK+ +
Sbjct: 628 -IKNPEERQIHD----IVEHAKKEHGVELEVDKEYRYV-VLSNRKKNYFGVTKSGKVDVK 681
Query: 607 GLEIVRRDWSEIAKETQAKVLEAILKHGNVDE----AVKIVKEVT---EKLSKYEIPPEK 659
GL + KE +L+ + DE +KI K + ++L + +P
Sbjct: 682 GLTGKKSHTPPFIKELFYSLLDILSAVQTEDEFESAKLKISKAIAASGKRLEERGVPLAD 741
Query: 660 LVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYI 702
L I++ SEY P A RL +VK G +I Y+
Sbjct: 742 LAFNVMISKAPSEYVKTVPQHIRAARLLENAREVKKGDIISYV 784
>gb|AAC57976.2| (AF005479) DNA polymerase [retroperitoneal fibromatosis-associated
herpesvirus]
Length = 1013
Score = 166 bits (416), Expect = 9e-40
Identities = 151/575 (26%), Positives = 252/575 (43%), Gaps = 80/575 (13%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE-------KLGIKLPLGR--DN 236
SE +M+ +IR+ D D I YN NFD PY++ RA K K+ G +
Sbjct: 356 SEYDMLVAFFAMIRDYDVDFITGYNIANFDLPYIITRATQVYNIDLKSFTKIKTGSIFEV 415
Query: 237 SEPKMQRMG---DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAH 293
EP G V+I G + D++ V R ++L Y L+ V + GK K+ +
Sbjct: 416 HEPAGGSGGFMRSQSKVKISGIVPIDMYQVCREKLSLSDYKLDTVAKKCLGKQKDDISYR 475
Query: 294 EIAEAWETGK-GLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSSTG 350
+I + +G G ++ +Y + D+ + +L + F A++ARL P V
Sbjct: 476 DIPPLFRSGAAGRAKIGRYCVIDSVLVMDLLRMFQTHVEIAEIARLAKIPARRVLTDGQQ 535
Query: 351 NLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSL 409
V LL A + + P + Y+G V P G ++ ++ +DF SL
Sbjct: 536 IRVFSCLLEAASQEGYILPVPNGDTT------GGYQGATVINPIPGFYDDPVLVVDFASL 589
Query: 410 YPSIIITHNVSPDTLNRENC---------KEYDVAPQVGH--RFCKDF--PGFIPSLLGN 456
YPSI+ HN+ TL + N +Y+ G F K + LL
Sbjct: 590 YPSIMQAHNLCYSTLIQGNAILSHPELTPNDYETFHLSGGPVHFVKKHVRESLLSKLLTT 649
Query: 457 LLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTA 516
L +R++I+K + DP + +LD +Q AIK+ N+ YG+ G A C AE+VT
Sbjct: 650 WLTKRKEIRKNLASCGDPTMRTILDKQQLAIKVTCNAVYGFTGVASGILPCLNIAETVTL 709
Query: 517 WGRQYI----------------DLVRRELES---RGFKVLYIDTDGLYATIPGAKHEEIK 557
GR+ + DL++R +++ FKV+Y DTD L+ G + +
Sbjct: 710 QGRKMLETSQAFVEGISPKDLSDLIQRPIDASPDARFKVIYGDTDSLFVCCIGYGTDSVS 769
Query: 558 EKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWS 616
A L ++LE E + +TKK+Y I + K++ +G++++R+
Sbjct: 770 SFADNLAAVTTRTLFKHPIKLEAEKIFQCLLLLTKKRYVGILTDEKMLMKGVDLIRKTAC 829
Query: 617 EIAKETQAKVLEAILKHGNVDEAVKIVKEVT------------------------EKLSK 652
+ +ET +++LE +L+ V A K++ + +L
Sbjct: 830 KFVQETSSQILELLLRDPAVKAAAKLISQQPTGWVYQEGLPQGLLKIITILNHSYHRLES 889
Query: 653 YEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRL 686
E+P EKL ++ RP+ EYK PH+AV ++L
Sbjct: 890 GEVPVEKLCFTTELGRPVCEYKTQSLPHLAVYRKL 924
>sp|P30320|DPOL_CHVN2 DNA POLYMERASE >gi|281076|pir||B42543 DNA-directed DNA polymerase
(EC 2.7.7.7) - Chlorella virus CV-NY-2A
>gi|323322|gb|AAA88827.1| (M86837) DNA polymerase
[Paramecium bursaria Chlorella virus NY2A]
Length = 913
Score = 164 bits (410), Expect = 4e-39
Identities = 172/631 (27%), Positives = 298/631 (46%), Gaps = 88/631 (13%)
Query: 181 VEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSE 238
VE++S E +++ + +++++ DV I YN +D Y+ R+ + + G DN
Sbjct: 241 VEIISCAEEADVMNTWMTILQDEITDVSIGYNLWQYDLRYIHGRS-MMCVDDITGEDNV- 298
Query: 239 PKMQRMGDSLA----------------------VEIKGRIHFDLFPVIRRTINLPTYTLE 276
+++ +G L +++ G + DL R+ NL +Y+L
Sbjct: 299 -RLKNLGRLLVGGGEVIERDLSSNAFGQNKFFLLDMPGVMQIDLLQWFRKNRNLESYSLN 357
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETGKGLERV-AKYSMEDAKVTFELGKEFFPME--AQL 333
V + G K + A +I E +E G + A Y+ +D + +L K+ +E ++
Sbjct: 358 NVSKLYLGDQKNDLPAMQIFEKFEGGADDRAIIAAYARKDTDLPLKLLKKMAILEDITEM 417
Query: 334 ARLVGQPVWDVSRSSTGNLVEWF--LLRKAYERNELAPNKPDEREYERRLRESYEGGYVK 391
A V PV ++ G V F L+ KA + N P D++ + + YEG V
Sbjct: 418 ANAVKVPVDYIN--FRGQQVRAFSCLVGKARQMNYAIP---DDKMWT--VDGKYEGATVL 470
Query: 392 EPEKGLW-EGIVSLDFRSLYPSIIITHNVSPDTL-------NRENCKEYDVAPQVG---- 439
+ +KG + I +LDF SLYPSII HN+SP+TL N + Y++ +G
Sbjct: 471 DAKKGAYFTSIAALDFASLYPSIIRAHNMSPETLVMDKRFENLPGIEYYEIETGLGTFKY 530
Query: 440 ---HRFCKDFPGFIPSLLGNLLEERQKIKKRMKESK---DPVEKKLLDYRQRAIKILANS 493
+ + G +P+LL +L + R++ KK M E+K D + L D +QR+ KI+ NS
Sbjct: 531 PQKNDETGEGQGVVPALLDDLAKFRKQAKKHMAEAKKNDDEFREALYDAQQRSYKIVMNS 590
Query: 494 YYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELES--RGFKVLYIDTDG--LYATIP 549
YG+ G ++ C A SVTA GR+ I+ + + G +V+Y DTD + +P
Sbjct: 591 VYGFLGASRGFIPCVPIAASVTATGRKMIEHTAKRVTELLPGSEVIYGDTDSVMIRMKLP 650
Query: 550 GAKHEEIKEKALKFVEYI------NSKLPGLLELEYEGFYARGFFVTKKKYALI-----D 598
K ++ E+ K +++ + K P +LE+E Y +KK+YA I D
Sbjct: 651 DDKIHDMDEQ-FKMAKWLAGEITKDFKAPN--DLEFEKIYYPYILYSKKRYAAIKFEDPD 707
Query: 599 EEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPE 658
E+GK+ +GL +VRRD+S I +E + L+ IL + AV E K+ E P E
Sbjct: 708 EKGKVDVKGLALVRRDFSPITREILKESLDTILFKKDTPTAVTETVECIRKVLDNEYPME 767
Query: 659 KLVIYEQITRPLSEYK-AIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRGDGPI-SKRAI 715
K + + + + YK PH+ V+ ++ + G V G + ++ + + +K++
Sbjct: 768 KFTMSKTLK---TGYKNECQPHLHVSNKIFERTGFPVPSGARVPFVYIEDKKNLDTKQSF 824
Query: 716 AIEEFDPKKHK-----YDAEYYIENQVLPAV 741
E DP + D +YIE+Q++ +
Sbjct: 825 RAE--DPTFAQENDLIVDRLFYIEHQLMKPI 853
>pir||A42543 DNA-directed DNA polymerase (EC 2.7.7.7) - Chlorella virus PBCV-1
Length = 913
Score = 164 bits (410), Expect = 4e-39
Identities = 181/661 (27%), Positives = 312/661 (46%), Gaps = 95/661 (14%)
Query: 181 VEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSE 238
VE +S E +++ +K+++++ DV I YN +D Y+ R + + + G D +
Sbjct: 241 VETISCLEESDVMNTWMKILQDEKTDVSIGYNTWQYDLRYVHGRTQ-MCVDDMTGED--K 297
Query: 239 PKMQRMGDSLA----------------------VEIKGRIHFDLFPVIRRTINLPTYTLE 276
K+ +G L+ +++ G + DL R+ NL +Y+L
Sbjct: 298 VKLSNLGRLLSGGGEVVERDLSWNAFGQNKFFLLDMPGVMQIDLLQWFRKNRNLESYSLN 357
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETGKGLER--VAKYSMEDAKVTFELGKEFFPME--AQ 332
V + G K + A +I E +E G +R +A Y+ +D + +L K+ +E +
Sbjct: 358 NVSKLYLGDQKNDLPAMQIFEKFE-GNAEDRAIIAAYAAKDTDLPLKLLKKMAILEDLTE 416
Query: 333 LARLVGQPVWDVSRSSTGNLVEWF--LLRKAYERNELAPNKPDEREYERRLRESYEGGYV 390
+A V PV ++ G + F L+ KA + N P D++ + + YEG V
Sbjct: 417 MANAVKVPVDYIN--FRGQQIRAFSCLVGKARQMNYAIP---DDKAWATEGK--YEGATV 469
Query: 391 KEPEK-GLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKE-------YDVAPQVGH-R 441
+ + + I +LDF SLYPSII HN+SP+TL E E Y++ +G +
Sbjct: 470 LDAKNPAYFTPIAALDFASLYPSIIRAHNMSPETLVMEKRFENVPGVEYYEIETGLGKFK 529
Query: 442 FCK------DFPGFIPSLLGNLLEERQKIKKRMKESK---DPVEKKLLDYRQRAIKILAN 492
+ + + G +P+LL +L + R+ KK M E+K D ++ L D +QR+ K++ N
Sbjct: 530 YAQKNDETGEGQGVVPALLDDLAKFRKLAKKHMAEAKRNGDDFKEALYDAQQRSFKVVMN 589
Query: 493 SYYGYYGYAKARWYCKECAESVTAWGRQYID-LVRRELE-SRGFKVLYIDTDGLYA--TI 548
S YG+ G +K C A SVTA GR+ I+ +R +E G +V+Y DTD + +
Sbjct: 590 SVYGFLGASKGFIPCVPIAASVTATGRKMIEHTAKRAVELLPGSEVIYGDTDSVMVKMKL 649
Query: 549 PGAKHEEIKEKALKFVEYINSKLP----GLLELEYEGFYARGFFVTKKKYALI-----DE 599
P K ++ E+ K +++ ++ +LE+E Y +KK+YA + DE
Sbjct: 650 PDDKVHDMDEQ-FKMAKWLAGEITKDFRAPNDLEFEKIYYPYILYSKKRYAAVKFEEPDE 708
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEK 659
+GK+ +GL +VRRD+S I ++ + L+ IL + AV E K+ E P EK
Sbjct: 709 KGKVDVKGLALVRRDFSPITRDILKESLDTILYKKDTPTAVSETLERIRKVLDNEYPMEK 768
Query: 660 LVIYEQITRPLSEYK-AIGPHVAVAKRLAAK-GVKVKPGMVIGYIVLRG-DGPISKRAIA 716
++ + + + YK PH+ VA ++ + G V G + ++ + P K++
Sbjct: 769 FMMSKTLK---TGYKNECQPHLHVANKIYERTGFPVPSGARVPFVYIEDKKNPDIKQSFK 825
Query: 717 IEEFDPKKHK-----YDAEYYIENQVLPAV----ERIL-----RAFGYRKEDLKYQKTKQ 762
E DP + D +YIE+Q+L + E +L FG+R K + K
Sbjct: 826 AE--DPTFAQDNGLIVDRLFYIEHQLLKPICSLFEPLLDDPEKEIFGHRLIKEKIENLKN 883
Query: 763 V 763
V
Sbjct: 884 V 884
>gb|AAF16520.1|AF191042_1 (AF191042) DNA-dependent DNA polymerase [porcine lymphotropic
herpesvirus 1]
Length = 1004
Score = 163 bits (409), Expect = 6e-39
Identities = 156/610 (25%), Positives = 267/610 (43%), Gaps = 99/610 (16%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSE------- 238
SE +M+ +IR+ D ++I YN NFDFPY+L RA + P ++
Sbjct: 345 SELDMLYAFCTMIRDYDVEIITGYNISNFDFPYILDRANMVYNINPDAYTRTKSGAIFQV 404
Query: 239 --PKMQR-MGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEI 295
PK + + V++ G + D++ V + ++L Y L V + G+ KE + EI
Sbjct: 405 HKPKEGNFLRSNTKVKLSGLVVIDMYMVCKDKLSLSNYKLNTVAKECIGEKKEDMSYKEI 464
Query: 296 AEAWE-TGKGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSSTGNL 352
++ R+ Y ++D+ + +L K F +++A++ P+ V
Sbjct: 465 PALFKGNANDRARLGLYCIQDSVLVMDLLKFFMTHIEISEIAKIANIPMRRVITDGQQIR 524
Query: 353 VEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSLYP 411
V LL A R + P P ++ Y+G V P G + ++ +DF SLYP
Sbjct: 525 VFSCLLASAKNRGYILP-MPQNGNFQ-----GYQGATVITPLSGFYNTPVLVVDFASLYP 578
Query: 412 SIIITHNVSPDTL-NRENCKEYDVAPQVGHRFCKDFPGFI--------------PSLLGN 456
SII HN+ TL + E+ +Y PQ+ +D+ F+ SLL N
Sbjct: 579 SIIQAHNLCYSTLIHHEDLHKY---PQLKE---EDYETFLISSGPVHFVKKHISESLLSN 632
Query: 457 LLE----ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAE 512
LL +R+ I+K + DP + +LD +Q AIK+ N+ YG+ G A C + AE
Sbjct: 633 LLTTWLAKRKMIRKELAACADPKLRTILDKQQLAIKVTCNAVYGFTGVASGMLPCLKIAE 692
Query: 513 SVTAWGRQYIDLVRRELES-----------------------RGFKVLYIDTDGLYATIP 549
++T GR ++ + +E+ + FKV+Y DTD L+ P
Sbjct: 693 TITMQGRAMLEKTKVFVENLSHEDLHSICKVGFMPQSPNSIDKPFKVIYGDTDSLFINCP 752
Query: 550 GAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGL 608
++I + ++I +L ++LE E + +TKK+Y I GKI+ +G+
Sbjct: 753 RYNMDQIVAFGDELAQHITERLFVSPIKLESEKVFGCLLLLTKKRYIGILSSGKILMKGV 812
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEA------------------------VKIVK 644
++VR+ +ET VL +L V EA + I+
Sbjct: 813 DLVRKTACTYVQETCKAVLHLVLNDNTVKEAANLLSKRKISRCFEEGLPEGFMKIIDILN 872
Query: 645 EVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKVKPGMV---IG 700
+ LS +P + L+ ++ + S YK+ PH+AV K++ + +P V I
Sbjct: 873 AAYKDLSANRVPIQTLIYSTELNKDFSCYKSYNLPHLAVYKKIILR--NEEPPQVHDRIS 930
Query: 701 YIVLRGDGPI 710
Y+ + G G +
Sbjct: 931 YVFINGKGSL 940
>gb|AAF16522.1|AF191043_1 (AF191043) DNA-dependent DNA polymerase [porcine lymphotropic
herpesvirus 2]
Length = 1001
Score = 163 bits (408), Expect = 7e-39
Identities = 156/610 (25%), Positives = 266/610 (43%), Gaps = 99/610 (16%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLP----------LGRD 235
SE +M+ +IR+ D ++I YN NFDFPY+L+RA + P + +
Sbjct: 345 SELDMLYAFCTMIRDYDVEIITGYNIANFDFPYILERANTVYNINPDAYTRTKSGAIFQV 404
Query: 236 NSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEI 295
N + + + V++ G + D++ V + ++L Y L V + G+ KE + EI
Sbjct: 405 NKPKEGNFLRSNTKVKLSGLVVIDMYMVCKDKLSLSNYKLNTVAKECIGEKKEDMSYKEI 464
Query: 296 AEAWE-TGKGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSSTGNL 352
++ R+ Y ++D+ + +L K F +++A++ P+ V
Sbjct: 465 PALFKGNANDRARLGLYCIQDSILVMDLLKFFMTHIEISEIAKIANIPMRRVITDGQQIR 524
Query: 353 VEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSLYP 411
V LL A R + P P ++ Y+G V P G + ++ +DF SLYP
Sbjct: 525 VFSCLLASAKNRGYILP-MPQNGNFQ-----GYQGATVIAPLSGFYNTPVLVVDFASLYP 578
Query: 412 SIIITHNVSPDTL-NRENCKEYDVAPQVGHRFCKDFPGFI--------------PSLLGN 456
SII HN+ TL + E+ +Y PQ+ D+ F+ SLL N
Sbjct: 579 SIIQAHNLCYSTLIHNEDLHKY---PQLKE---DDYETFLISSGPVHFVKKHISESLLSN 632
Query: 457 LLE----ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAE 512
LL +R+ I+K + DP + +LD +Q AIK+ N+ YG+ G A C + AE
Sbjct: 633 LLTTWLAKRKMIRKELTACADPKLRTILDKQQLAIKVTCNAVYGFTGVASGMLPCLKIAE 692
Query: 513 SVTAWGRQYIDLVRRELES-----------------------RGFKVLYIDTDGLYATIP 549
++T GR ++ + +E+ + FKV+Y DTD L+ P
Sbjct: 693 TITMQGRAMLEKTKVFVENLSHEDLRSICKVGSIPQSSNVFDKPFKVIYGDTDSLFINCP 752
Query: 550 GAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGL 608
++I + +YI +L ++LE E + +TKK+Y GKI+ +G+
Sbjct: 753 KYNIDQIVLFGDELAQYITERLFVSPIKLESEKVFGCLLLLTKKRYIGTLSSGKILMKGV 812
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEA------------------------VKIVK 644
++VR+ +ET VL +L V EA + I+
Sbjct: 813 DLVRKTACTYVQETCRAVLHLVLNDNTVKEAANLLSKRKISKCFEEGLPEGFIKIIDILN 872
Query: 645 EVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKVKPGMV---IG 700
+ LS +P + LV ++ + S YK+ PH+AV K++ + +P V I
Sbjct: 873 AAYKDLSANRVPIQTLVYSTELNKDFSCYKSYNLPHLAVYKKIILR--NEEPPQVHDRIS 930
Query: 701 YIVLRGDGPI 710
Y+ + G G +
Sbjct: 931 YVFINGKGSL 940
>gb|AAG20982.1| (AE005165) DNA polymerase B2; PolB2 [Halobacterium sp. NRC-1]
Length = 722
Score = 163 bits (408), Expect = 7e-39
Identities = 125/459 (27%), Positives = 224/459 (48%), Gaps = 26/459 (5%)
Query: 315 DAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDE 374
D TF G+ L PV +++ +S GN++ + +A +R L P
Sbjct: 250 DESNTFFYGETNLDGVLDLVSRSKNPVQELAWASIGNVLTAIQICEANDRGVLVPWNSWR 309
Query: 375 REYER---RLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKE 431
E+ + L ++ GG++ PE GL E + LDF SLYP+II T NVSPD + + +
Sbjct: 310 HEFYKPMGTLHDADRGGFIFAPEVGLHENVHELDFSSLYPNIICTRNVSPDVIRCDCHSD 369
Query: 432 YDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIK---KRMKESKDPVEKKL--LDYRQRA 486
D P +G+ C D G++ +L +++ R +IK +R + DP E +L L+ R A
Sbjct: 370 RDDVPGLGYSICDD-RGYLVDVLQPIIDARDEIKAAIRRETDRDDPDEDRLAELEGRSGA 428
Query: 487 IKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYA 546
+K + + +GY G++ A++ EC E++ A+ R+ + + ++ LE+ G++V++ D ++
Sbjct: 429 LKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLMAKQRLEAGGWRVVHGIVDSIWV 488
Query: 547 TIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKY---ALIDEEGKI 603
T EE +E I ++ + LE+E Y FV +++ AL GK+
Sbjct: 489 TPDPDVDEEDREDLQTLATEITERVE--IRLEHEAHYDWVAFVPQRESDAGALTKYFGKV 546
Query: 604 V------TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPP 657
RG+E +R ++ Q L+ + + D + ++ ++L +
Sbjct: 547 AGDDDFKVRGIEARQRSTPPFIEDVQRDCLDRLDATRSPDAVLGRLERAIDELQAGNVAV 606
Query: 658 EKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIVLRGDGPISKR-AIA 716
E+LV ++++PL Y +VA KR + + V PG I Y+V+ + R A+A
Sbjct: 607 ERLVERNRVSKPLEGYSQNTQNVAALKRAREQDLAVHPGQDIEYVVVDDEKSSRDRVALA 666
Query: 717 IEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKEDL 755
E + YD YY E Q++ AVE +L G+ + ++
Sbjct: 667 HEAIE----TYDTSYY-ETQLVRAVESVLSPLGWDRSNI 700
>gb|AAC57086.1| (U75698) ORF 9; DNA polymerase homolog; EBV BALF5 homolog [Kaposi's
sarcoma-associated herpesvirus]
>gi|8714519|gb|AAC57974.2| (AF005477) DNA polymerase
[Kaposi's sarcoma-associated herpesvirus]
Length = 1012
Score = 161 bits (403), Expect = 3e-38
Identities = 148/590 (25%), Positives = 263/590 (44%), Gaps = 84/590 (14%)
Query: 178 LPYVEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL--------- 226
LP VEV SE +M+ + ++R+ + + I YN NFD PY++ RA ++
Sbjct: 344 LPGVEVFEFPSEYDMLAAFLSMLRDYNVEFITGYNIANFDLPYIIARATQVYDFKLQDFT 403
Query: 227 GIKLPLGRDNSEPKMQRMGDSLA-----VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEA 281
IK + +P+ G + V+I G + D++ V R ++L Y L+ V +
Sbjct: 404 KIKTGSVFEVHQPRGGSDGGNFMRSQSKVKISGIVPIDMYQVCREKLSLSDYKLDTVAKQ 463
Query: 282 IFGKSKEKVYAHEIAEAWETGK-GLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVG 338
G+ K+ + +I +++G G +V Y + D+ + +L F +++A+L
Sbjct: 464 CLGRQKDDISYKDIPPLFKSGPDGRAKVGNYCVIDSVLVMDLLLRFQTHVEISEIAKLAK 523
Query: 339 QPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW 398
P V V LL A + P + Y+G V P G +
Sbjct: 524 IPTRRVLTDGQQIRVFSCLLEAAATEGYILPVPKGDAV------SGYQGATVISPSPGFY 577
Query: 399 EG-IVSLDFRSLYPSIIITHNVSPDTLNRENC---------KEYDVAPQVGH--RFCKDF 446
+ ++ +DF SLYPSII HN+ TL + +Y+ G F K
Sbjct: 578 DDPVLVVDFASLYPSIIQAHNLCYSTLIPGDSLHLHPHLSPDDYETFVLSGGPVHFVKKH 637
Query: 447 P--GFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKAR 504
+ LL L +R++I+K + DP K +LD +Q AIK+ N+ YG+ G A
Sbjct: 638 KRESLLAKLLTVWLAKRKEIRKTLASCTDPALKTILDKQQLAIKVTCNAVYGFTGVASGI 697
Query: 505 WYCKECAESVTAWGRQYID----------------LVRRELE---SRGFKVLYIDTDGLY 545
C AE+VT GR+ ++ L+RR ++ FKV+Y DTD L+
Sbjct: 698 LPCLNIAETVTLQGRKMLERSQAFVEAISPERLAGLLRRPIDVSPDARFKVIYGDTDSLF 757
Query: 546 ATIPGAKHEEIKEKALKFVEY-INSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIV 604
G + + + A + N+ ++LE E + +TKK+Y + + K++
Sbjct: 758 ICCMGFNMDSVSDFAEELASITTNTLFRSPIKLEAEKIFKCLLLLTKKRYVGVLSDDKVL 817
Query: 605 TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVK-EVTE--------------- 648
+G++++R+ +E ++VL+ IL+ +V A K++ + T+
Sbjct: 818 MKGVDLIRKTACRFVQEKSSQVLDLILREPSVKAAAKLISGQATDWVYREGLPEGFVKII 877
Query: 649 --------KLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAK 689
+L + +P +KL +++RPL++YK PH+ V ++L A+
Sbjct: 878 QVLNASHRELCERSVPVDKLTFTTELSRPLADYKTQNLPHLTVYQKLQAR 927
>gb|AAB62593.1| (U93872) ORF 09, DNA polymerase homolog [Kaposi's
sarcoma-associated herpesvirus]
Length = 1012
Score = 161 bits (403), Expect = 3e-38
Identities = 148/590 (25%), Positives = 263/590 (44%), Gaps = 84/590 (14%)
Query: 178 LPYVEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL--------- 226
LP VEV SE +M+ + ++R+ + + I YN NFD PY++ RA ++
Sbjct: 344 LPGVEVFEFPSEYDMLAAFLSMLRDYNVEFITGYNIANFDLPYIIARATQVYDFKLQDFT 403
Query: 227 GIKLPLGRDNSEPKMQRMGDSLA-----VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEA 281
IK + +P+ G + V+I G + D++ V R ++L Y L+ V +
Sbjct: 404 KIKTGSVFEVHQPRGGSDGGNFMRSQSKVKISGIVPIDMYQVCREKLSLSDYKLDTVAKQ 463
Query: 282 IFGKSKEKVYAHEIAEAWETGK-GLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVG 338
G+ K+ + +I +++G G +V Y + D+ + +L F +++A+L
Sbjct: 464 CLGRQKDDISYKDIPPLFKSGPDGRAKVGNYCVIDSVLVMDLLLRFQTHVEISEIAKLAK 523
Query: 339 QPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW 398
P V V LL A + P + Y+G V P G +
Sbjct: 524 IPTRRVLTDGQQIRVFSCLLEAAATEGYILPVPKGDAV------SGYQGATVISPSPGFY 577
Query: 399 EG-IVSLDFRSLYPSIIITHNVSPDTLNRENC---------KEYDVAPQVGH--RFCKDF 446
+ ++ +DF SLYPSII HN+ TL + +Y+ G F K
Sbjct: 578 DDPVLVVDFASLYPSIIQAHNLCYSTLIPGDSLHLHPHLSPDDYETFVLSGGPVHFVKKH 637
Query: 447 P--GFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKAR 504
+ LL L +R++I+K + DP K +LD +Q AIK+ N+ YG+ G A
Sbjct: 638 KRESLLAKLLTVWLAKRKEIRKTLASCTDPALKTILDKQQLAIKVTCNAVYGFTGVASGI 697
Query: 505 WYCKECAESVTAWGRQYID----------------LVRRELE---SRGFKVLYIDTDGLY 545
C AE+VT GR+ ++ L+RR ++ FKV+Y DTD L+
Sbjct: 698 LPCLNIAETVTLQGRKMLERSQAFVEAISPERLAGLLRRPIDVSPDARFKVIYGDTDSLF 757
Query: 546 ATIPGAKHEEIKEKALKFVEY-INSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIV 604
G + + + A + N+ ++LE E + +TKK+Y + + K++
Sbjct: 758 ICCMGFNMDSVSDFAEELASITTNTLFRSPIKLEAEKIFKCLLLLTKKRYVGVLSDDKVL 817
Query: 605 TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVK-EVTE--------------- 648
+G++++R+ +E ++VL+ IL+ +V A K++ + T+
Sbjct: 818 MKGVDLIRKTACRFVQEKSSQVLDLILREPSVKAAAKLISGQATDWVYREGLPEGFVKII 877
Query: 649 --------KLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAK 689
+L + +P +KL +++RPL++YK PH+ V ++L A+
Sbjct: 878 QVLNASHRELCERSVPVDKLTFTTELSRPLADYKTQNLPHLTVYQKLQAR 927
>gi|10140935 DNA Polymerase [Alcelaphine herpesvirus 1] >gi|7434795|pir||T03108
DNA-directed DNA polymerase (EC 2.7.7.7) - alcelaphine
herpesvirus 1 >gi|2337976|gb|AAC58060.1| (AF005370) DNA
Polymerase [Alcelaphine herpesvirus 1]
Length = 1026
Score = 161 bits (403), Expect = 3e-38
Identities = 155/610 (25%), Positives = 263/610 (42%), Gaps = 104/610 (17%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQR-- 243
SE +++ ++R+ ++I YN NFDFPY+L RA+ + P D S+ K
Sbjct: 375 SEMDLLYGFFTLLRDYGIEMITGYNICNFDFPYILNRAQNVYNIKP--EDFSKTKTNSLF 432
Query: 244 ----------MGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAH 293
M V++ G + D++ V R +NL Y L V + G+ K V
Sbjct: 433 YVYTPQEGNFMRSHSKVKMSGVVVIDMYQVCRDKLNLSNYKLNTVAKECLGEKKNDVSYK 492
Query: 294 EIAEAWE-TGKGLERVAKYSMEDAKVTFELGKEFFPME--AQLARLVGQPVWDVSRSSTG 350
+I ++ + K ++ Y ++DA + +L K F ++A++ P V
Sbjct: 493 DIPILFKGSSKDRAKLGMYCVQDAVLVIDLLKHFMTHIEITEIAKIANIPTRRVLSDGQQ 552
Query: 351 NLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSL 409
V LL A ER+ + P + E Y+G V P G + ++ +DF SL
Sbjct: 553 IRVFTCLLAAAQERDYILPMPVTGSQ------EGYQGATVINPISGFYNTPVLVVDFASL 606
Query: 410 YPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGF------------------IP 451
YPSII HN+ TL K+ D+ P+ + D+ F +
Sbjct: 607 YPSIIQAHNLCYSTL----IKQQDL-PKFTNLTANDYETFMISGGPVHFVKKHKTESLLA 661
Query: 452 SLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECA 511
SLL L +R+ IKK +++ +D K +LD +Q AIK+ NS YG+ G A C A
Sbjct: 662 SLLKTWLAKRKSIKKELEQCQDAKMKTILDKQQLAIKVTCNSVYGFTGVASGMLPCLMIA 721
Query: 512 ESVTAWGRQYIDLVRRELE----------------------SRGFKVLYIDTDGLYATIP 549
E+VT GR ++ ++ +E + F+V+Y DTD L+
Sbjct: 722 ETVTLQGRTMLEKTKQFVENVTVEYLQKICNFEVQCLPQHPNPKFRVVYGDTDSLFIKCE 781
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLL-----ELEYEGFYARGFFVTKKKYALIDEEGKIV 604
G + + +KF + + S +L +LE E + +TKK+Y I KI+
Sbjct: 782 GFAMDTV----IKFGDALASHTSSVLFASPIKLESEKVFKCLMLLTKKRYVGILSNNKIL 837
Query: 605 TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEA------------------------V 640
+G+++VR+ +E VLE +L+ V A +
Sbjct: 838 MKGVDLVRKTACVYVQEVTRAVLELLLRDEEVKVAAQTLSYSPVANCFKTEPLLGFLKII 897
Query: 641 KIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV-KPGMV 698
I+ + L ++P L ++++P +EYK PH+AV K+LA + ++ +
Sbjct: 898 DILNQSYSDLKSNKVPVANLTYSTELSKPFTEYKTTNLPHLAVYKKLAMRNEELPQIHDR 957
Query: 699 IGYIVLRGDG 708
I Y+ ++ +G
Sbjct: 958 ISYVFVKSNG 967
>sp|O71121|DPOL_RHCM6 DNA POLYMERASE >gi|2944240|gb|AAC05256.1| (AF033184) DNA polymerase
[Rhesus cytomegalovirus]
Length = 1035
Score = 159 bits (398), Expect = 1e-37
Identities = 154/610 (25%), Positives = 261/610 (42%), Gaps = 78/610 (12%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMG 245
SE EM+ + + P + YN ++FDF Y+L R E + KL G + P R
Sbjct: 358 SEYEMLLGFLIFFQRYSPCFVTGYNINSFDFKYILTRLEFV-YKLSPGPYSKLPAQGRFS 416
Query: 246 -----------DSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHE 294
+ V I G + D++PV + P Y L + E + KE + +
Sbjct: 417 MYSPLKKFVTTTTTKVFISGTVVIDMYPVCMAKTSSPNYKLNTMAELYLKQQKEDMSYKD 476
Query: 295 IAEAWETG-KGLERVAKYSMEDAKVTFELGKEF-FPMEA-QLARLVGQPVWDVSRSSTGN 351
I + +G +G +V KY ++DA + +L F EA +ARL P+ V
Sbjct: 477 IPVKFISGCEGRAQVGKYCVQDAVLVKDLFNTINFHYEAGAIARLARIPMRRVIFDGQQI 536
Query: 352 LVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-EGIVSLDFRSLY 410
+ LL + R+ + PN SY+G V EPE G + + +V DF SLY
Sbjct: 537 RIYTSLLDECACRDFIMPNHKGADNSSEPTDVSYQGATVFEPEVGYYSDPVVVFDFASLY 596
Query: 411 PSIIITHNVSPDTL---NRENCKEYDVAPQ-----VGHRFCKDFP--GFIPSLLGNLLEE 460
PSII+ HN+ T E+ E DV + +RF K+ + LL + +
Sbjct: 597 PSIIMAHNLCYSTFVAPGGESPPESDVLTVELESGLSYRFVKNTVRNSVLSELLTKWVSQ 656
Query: 461 RQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQ 520
R+ +++ M+ DPV++ LLD Q A+K+ N++YG+ G C A S+T GR
Sbjct: 657 RRAVRETMRSCHDPVKRMLLDKEQLALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRD 716
Query: 521 YIDLVRRELESR---------------------GFKVLYIDTDGLYATIPGAKHEEIKEK 559
+ + +E KV+Y DTD ++ G + E+
Sbjct: 717 MLMRTSQFVEENFAEPCFLHNFFNREDYSGDPVAVKVIYGDTDSVFVCYRGVTAAALIER 776
Query: 560 ALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKY-ALIDEEGKIVTRGLEIVRRDWSE 617
YI L ++LE+E + + KK+Y I E ++ +G+++VR+ E
Sbjct: 777 GPSLAHYITQCLFVDPIKLEFEKVFGSLMMICKKRYIGKIVGETELSMKGVDLVRKTSCE 836
Query: 618 IAKETQAKVLEAILKHGNVDE-AVKIVKEVTEKLSKYEIPP------------------- 657
K +++ + V AV++ + ++L +PP
Sbjct: 837 FVKNVTRDIIQLLFDDPEVSRAAVQLSRLTLDELKMQGVPPGFGRVIQRLSQARDELYTS 896
Query: 658 ----EKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKVK-PGMVIGYIVLRGDGPIS 711
E+LV+ +++ +S YK PH+AV KRLAA+ ++ G + Y++ P+
Sbjct: 897 RARVEELVLSSVLSKDVSLYKQSNLPHIAVIKRLAARSEELPVVGDRVFYVL---TAPVD 953
Query: 712 KRAIAIEEFD 721
R+ + ++
Sbjct: 954 GRSSGVRNYE 963
>pir||G83410 DNA polymerase II PA1886 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9947877|gb|AAG05275.1|AE004614_9
(AE004614) DNA polymerase II [Pseudomonas aeruginosa]
Length = 787
Score = 159 bits (397), Expect = 1e-37
Identities = 198/776 (25%), Positives = 339/776 (43%), Gaps = 128/776 (16%)
Query: 54 ITAERHGKIVRITEVEK-------VQKKFLGRPIEVWKLYLEHPQDVPAIREKIREHPAV 106
+ AE+ G++ + E + F RP V LY + + + + +++R+ A
Sbjct: 46 VLAEQRGRVESLLAGETGAELRPLALRDFQQRP--VLGLYCQQHRQLMNLEKRLRQ--AG 101
Query: 107 VDIFEYDIPFAKRYLIDKGLTP---MEGNEE-------------------LTFLAVDIET 144
V++FE DI +RYL+++ +T +E + E L +++DIET
Sbjct: 102 VEVFEADIRPPERYLMERFITAPVSLEASVEADGSLLARRLKPAPDYRPRLRLVSLDIET 161
Query: 145 -----LYHEG-EEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVI 198
LY E + + M+ A+ + A V L Y + S +++RL + +
Sbjct: 162 NARGDLYSIALEGCDQRQVYMLGPANGDAAAV----DFRLDYCD---SRAGLLERLNQWL 214
Query: 199 REKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRMG---DSLAVEIKGR 255
E DPD II +N FD L + A++L + L LGR E + G + GR
Sbjct: 215 AEHDPDAIIGWNLVQFDLRVLHEHAQRLKVPLRLGRGGDEMGWREHGSRNNHFFAAAAGR 274
Query: 256 IHFDLFPVIRR-TINLPTYTLEAVYEAIFGKSK--EKVYAH--EIAEAWETGKGLERVAK 310
+ D +R T + P+++LE V + G+ K + Y EI + K +A
Sbjct: 275 LIIDGIEALRSATWSFPSFSLENVARTLLGEGKAIDNPYQRMDEIDRMFAEDK--PALAH 332
Query: 311 YSMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELA 368
Y+++D ++ + E + A + G P D S S ++ + +A
Sbjct: 333 YNLKDCELVTRIFARTELLDFLLERATVTGLPA-DRSGGSVAAFTHLYM-PLMHRAGFVA 390
Query: 369 PNKPDEREYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLN--- 425
PN ++R E+ GG+V + GL+E ++ LD++SLYPSII T + P L
Sbjct: 391 PNLGEKRP------EASPGGFVMDSRPGLYESVLVLDYKSLYPSIIRTFLIDPVGLVEGL 444
Query: 426 RENCKEYDVAPQVGHRFCKDFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQR 485
R+ E+ V G RF + +P+++ + E R+ K+ E P+ +
Sbjct: 445 RQPDDEHSVEGFRGARFSRT-RHCLPAIVARVWEGREAAKR---ERNQPLSQ-------- 492
Query: 486 AIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLY 545
A+KI+ N++YG G + R++ A S+T G + + R +E+ G+ V+Y DTD +
Sbjct: 493 ALKIIMNAFYGVLGSSGCRFFDPRLASSITLRGHRIMRRTRELIEAEGYTVIYGDTDSTF 552
Query: 546 ATIPGAK-HEEIKEKALKFVEYINS----------KLPGLLELEYEGFYARGFFVT---- 590
+ + EE V +N L LEL++E Y R T
Sbjct: 553 VWLGSPRAEEEAAAIGRALVARVNDWWREHLKEEFGLDSALELQFETHYRRFLMPTVRGA 612
Query: 591 ----KKKYALI----DEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKI 642
KK+YA + D ++V +GLE VR DWS +A+ Q E L+ N
Sbjct: 613 EEGSKKRYAGLVRRADGGEEMVFKGLETVRTDWSPLAQRFQQ---ELYLRIFNRQPYQDY 669
Query: 643 VKEVTEKLSKYEIPPEKLVIYEQITRPLSEY-KAIGPHVAVAKRLA-------AKGVKVK 694
V++ + E+ + LV +++ R L +Y + + PHV A R+A + + +
Sbjct: 670 VRDYVRRTLAGEL-DDLLVYRKRLRRRLDDYQRNVPPHVRAA-RIADDYNLERGRPRQYQ 727
Query: 695 PGMVIGYIV-LRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
G I Y++ + G P+ R AI D E+Y+ Q+ P + IL G
Sbjct: 728 SGGWISYVISVAGPEPLEARRSAI----------DYEHYVGKQLQPVADAILPFVG 773
>gb|AAF80107.1|AF268039_1 (AF268039) DNA polymerase; DPOL [porcine cytomegalovirus]
Length = 1007
Score = 158 bits (395), Expect = 3e-37
Identities = 156/610 (25%), Positives = 274/610 (44%), Gaps = 79/610 (12%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL---GI 228
T ID ++ E E+I + +++ P++I YN NFD YL+ RA KL G+
Sbjct: 321 TCDPIDDAHIYEFPCEYELIYAFLIFVKQVSPEIITGYNIINFDLNYLIIRATKLYRLGV 380
Query: 229 ----KLPLG----RDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYE 280
KL G + ++ K V G I D +PV I Y L+ +
Sbjct: 381 GEFTKLKKGLLCIKSTNDFKQGFNCIKTKVYASGMICIDFYPVCVGKITSDNYKLDTIAN 440
Query: 281 AIFGKSKEKVYAHEIAEAWETGKGLE-RVAKYSMEDAKVTFELGKEF-FPMEAQ-LARLV 337
GK KE + I + +G G +V +Y ++D+ + EL +F + MEA +++L
Sbjct: 441 LCLGKHKEDMPYKRIPIEFISGSGGRCKVGRYCIQDSMIVKELFCKFNYHMEASAISKLA 500
Query: 338 GQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGL 397
P+ V V +L + +RN L P+K RE ESY G V +P G
Sbjct: 501 YLPIRKVINDGQQRRVFTCILHETRKRNMLIPDKIAPRETGED--ESYRGATVLDPHVGY 558
Query: 398 WEG-IVSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD--------VAPQVGHRFCKDF 446
+ ++ +DF SLYPSI+I +N+ TL N E+ D V +RF +
Sbjct: 559 YASPVIVMDFASLYPSIMIANNLCYSTLILNDEDVTGIDEKDILTVHVNKNTVYRFVRSS 618
Query: 447 --PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKAR 504
+ +LL L +R+++K RMK +DP+ +LD +Q A+K+ N++YG+ G
Sbjct: 619 VRESILGTLLSRWLRKRKEVKARMKRCEDPMLALILDKQQLALKVTCNAFYGFTGAVHGL 678
Query: 505 WYCKECAESVTAWG----RQYIDLVRRELESRGF------------------KVLYIDTD 542
C A S+T+ G RQ D + L SR + V+Y DTD
Sbjct: 679 LPCLPLAASITSIGRDMLRQTSDFINNVLSSREYVSEKFSLSDGDFQGDFSLNVIYGDTD 738
Query: 543 GLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKY-ALIDEE 600
++ + E + +++S+L ++LE+E + + KK+Y + +
Sbjct: 739 SVFVCVKNIVPERLAGICADIAAHVSSQLFIEPIKLEFEKMFLPLMLICKKRYVGKMFDS 798
Query: 601 GKIVTRGLEIVRRD-----------------W-SEIAK---ETQAKVLEAILKHG---NV 636
++V +G+E+VR+ W SE+A+ E + ++++G +
Sbjct: 799 DELVMKGVELVRKTSCPFVKNIVKEIVRLLFWDSEVARAAVELSQMSCDEVIRNGLPAGI 858
Query: 637 DEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKVK- 694
+ + I+ ++L ++ +LV+ +++ +S YK PH+ V +RL + +V
Sbjct: 859 HKIIDIIIGARDRLYTNKVDVNELVLSTMLSKEISMYKQPNLPHLRVIERLRNRNEEVPV 918
Query: 695 PGMVIGYIVL 704
G + Y+++
Sbjct: 919 VGDRVSYVLI 928
>gb|AAF80108.1|AF268040_1 (AF268040) DNA polymerase; DPOL [porcine cytomegalovirus]
Length = 1007
Score = 157 bits (394), Expect = 3e-37
Identities = 159/612 (25%), Positives = 276/612 (44%), Gaps = 83/612 (13%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL---GI 228
T ID ++ E E+I + +++ P++I YN NFD YL+ RA KL G+
Sbjct: 321 TCDPIDDAHIYEFPCEYELIYAFLIFVKQVSPEIITGYNIINFDLNYLIIRATKLYRLGV 380
Query: 229 ----KLPLG----RDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYE 280
KL G + ++ K V G I D +PV I Y L+ +
Sbjct: 381 GEFTKLKKGLLCIKSTNDFKQGFNCIKTKVYASGMICIDFYPVCVGKITSDNYKLDTIAN 440
Query: 281 AIFGKSKEKVYAHEIAEAWETGKGLE-RVAKYSMEDAKVTFELGKEF-FPMEAQ-LARLV 337
GK KE + I + +G G +V +Y ++D+ + EL +F + MEA +++L
Sbjct: 441 LCLGKHKEDMPYKRIPIEFISGSGGRCKVGRYCIQDSVIVKELFCKFNYHMEASAISKLA 500
Query: 338 GQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGL 397
P+ V V +L + +RN L P+K RE ESY G V +P G
Sbjct: 501 YLPIRKVINDGQQRRVFTCILHETRKRNMLIPDKIAPRETGED--ESYRGATVLDPHVGY 558
Query: 398 WEG-IVSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD--------VAPQVGHRFCKDF 446
+ ++ +DF SLYPSI+I +N+ TL N E+ D V +RF +
Sbjct: 559 YASPVIVMDFASLYPSIMIANNLCYSTLILNDEDVTGIDEKDILTVHVNKNTVYRFVRS- 617
Query: 447 PGFIPSLLGNLLE----ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
G S+LG LL +R+++K RMK +DP+ +LD +Q A+K+ N++YG+ G
Sbjct: 618 -GVRESILGTLLSRWLRKRKEVKARMKRCEDPMLALILDKQQLALKVTCNAFYGFTGAVH 676
Query: 503 ARWYCKECAESVTAWG----RQYIDLVRRELESRGF------------------KVLYID 540
C A S+T+ G RQ D + L SR + V+Y D
Sbjct: 677 GLLPCLPLAASITSIGRDMLRQTSDFINNVLSSREYVSEKFGLSDGDFQGDFSLNVIYGD 736
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKY-ALID 598
TD ++ + E + +++S+L ++LE+E + + KK+Y +
Sbjct: 737 TDSVFVCVKNIVPERLAGICADISAHVSSQLFIEPIKLEFEKMFLPLMLICKKRYVGKMF 796
Query: 599 EEGKIVTRGLEIVRRD-----------------W-SEIAK---ETQAKVLEAILKHG--- 634
+ ++V +G+E+VR+ W SE+A+ E + ++++G
Sbjct: 797 DSDELVMKGVELVRKTSCPFVKNIVKEIVRLLFWDSEVARAAVELSQMSCDEVIRNGLPA 856
Query: 635 NVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV 693
+ + + I+ ++L ++ +LV+ +++ +S YK PH+ V +RL + +V
Sbjct: 857 GIHKIIDIIIGARDRLYTNKVDVNELVLSTMLSKEISMYKQPNLPHLRVIERLRNRNEEV 916
Query: 694 K-PGMVIGYIVL 704
G + Y+++
Sbjct: 917 PVVGDRVSYVLI 928
>gb|AAF80109.1|AF268041_1 (AF268041) DNA polymerase; DPOL [porcine cytomegalovirus]
Length = 1007
Score = 157 bits (394), Expect = 3e-37
Identities = 159/612 (25%), Positives = 276/612 (44%), Gaps = 83/612 (13%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL---GI 228
T ID ++ E E+I + +++ P++I YN NFD YL+ RA KL G+
Sbjct: 321 TCDPIDDAHIYEFPCEYELIYAFLIFVKQVSPEIITGYNIINFDLNYLIIRATKLYRLGV 380
Query: 229 ----KLPLG----RDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYE 280
KL G + ++ K V G I D +PV I Y L+ +
Sbjct: 381 GEFTKLKKGLLCIKSTNDFKQGFNCIKTKVYASGMICIDFYPVCVGKITSDNYKLDTIAN 440
Query: 281 AIFGKSKEKVYAHEIAEAWETGKGLE-RVAKYSMEDAKVTFELGKEF-FPMEAQ-LARLV 337
GK KE + I + +G G +V +Y ++D+ + EL +F + MEA +++L
Sbjct: 441 LCLGKHKEDMPYKRIPIEFISGSGGRCKVGRYCIQDSVIVKELFCKFNYHMEASAISKLA 500
Query: 338 GQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGL 397
P+ V V +L + +RN L P+K RE ESY G V +P G
Sbjct: 501 YLPIRKVINDGQQRRVFTCILHETRKRNMLIPDKIAPRETGED--ESYRGATVLDPHVGY 558
Query: 398 WEG-IVSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD--------VAPQVGHRFCKDF 446
+ ++ +DF SLYPSI+I +N+ TL N E+ D V +RF +
Sbjct: 559 YASPVIVMDFASLYPSIMIANNLCYSTLILNDEDVTGIDEKDILTVHVNKNTVYRFVRS- 617
Query: 447 PGFIPSLLGNLLE----ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
G S+LG LL +R+++K RMK +DP+ +LD +Q A+K+ N++YG+ G
Sbjct: 618 -GVRESMLGTLLSRWLRKRKEVKARMKRCEDPMLALILDKQQLALKVTCNAFYGFTGAVH 676
Query: 503 ARWYCKECAESVTAWG----RQYIDLVRRELESRGF------------------KVLYID 540
C A S+T+ G RQ D + L SR + V+Y D
Sbjct: 677 GLLPCLPLAASITSIGRDMLRQTSDFINNVLSSREYVSEKFGLSDGDFQGDFSLNVIYGD 736
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKY-ALID 598
TD ++ + E + +++S+L ++LE+E + + KK+Y +
Sbjct: 737 TDSVFVCVKNIVPERLAGICADISAHVSSQLFIEPIKLEFEKMFLPLMLICKKRYVGKMF 796
Query: 599 EEGKIVTRGLEIVRRD-----------------W-SEIAK---ETQAKVLEAILKHG--- 634
+ ++V +G+E+VR+ W SE+A+ E + ++++G
Sbjct: 797 DSDELVMKGVELVRKTSCPFVKNIVKEIVRLLFWDSEVARAAVELSQMSCDEVIRNGLPA 856
Query: 635 NVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV 693
+ + + I+ ++L ++ +LV+ +++ +S YK PH+ V +RL + +V
Sbjct: 857 GIHKIIDIIIGARDRLYTNKVDVNELVLSTMLSKEISMYKQPNLPHLRVIERLRNRNEEV 916
Query: 694 K-PGMVIGYIVL 704
G + Y+++
Sbjct: 917 PVVGDRVSYVLI 928
>gb|AAF80111.1|AF268042_2 (AF268042) DNA polymerase; DPOL [porcine cytomegalovirus]
Length = 1007
Score = 157 bits (394), Expect = 3e-37
Identities = 159/612 (25%), Positives = 276/612 (44%), Gaps = 83/612 (13%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL---GI 228
T ID ++ E E+I + +++ P++I YN NFD YL+ RA KL G+
Sbjct: 321 TCDPIDDAHIYEFPCEYELIYAFLIFVKQVSPEIITGYNIINFDLNYLIIRATKLYRLGV 380
Query: 229 ----KLPLG----RDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYE 280
KL G + ++ K V G I D +PV I Y L+ +
Sbjct: 381 GEFTKLKKGLLCIKSTNDFKQGFNCIKTKVYASGMICIDFYPVCVGKITSDNYKLDTIAN 440
Query: 281 AIFGKSKEKVYAHEIAEAWETGKGLE-RVAKYSMEDAKVTFELGKEF-FPMEAQ-LARLV 337
GK KE + I + +G G +V +Y ++D+ + EL +F + MEA +++L
Sbjct: 441 LCLGKHKEDMPYKRIPIEFISGSGGRCKVGRYCIQDSVIVKELFCKFNYHMEASAISKLA 500
Query: 338 GQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGL 397
P+ V V +L + +RN L P+K RE ESY G V +P G
Sbjct: 501 YLPIRKVINDGQQRRVFTCILHETRKRNMLIPDKIAPRETGED--ESYRGATVLDPHVGY 558
Query: 398 WEG-IVSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD--------VAPQVGHRFCKDF 446
+ ++ +DF SLYPSI+I +N+ TL N E+ D V +RF +
Sbjct: 559 YASPVIVMDFASLYPSIMIANNLCYSTLILNDEDVTGIDEKDILTVHVNKNTVYRFVRS- 617
Query: 447 PGFIPSLLGNLLE----ERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
G S+LG LL +R+++K RMK +DP+ +LD +Q A+K+ N++YG+ G
Sbjct: 618 -GVRESILGTLLSRWLRKRKEVKARMKRCEDPMLALILDKQQLALKVTCNAFYGFTGAVH 676
Query: 503 ARWYCKECAESVTAWG----RQYIDLVRRELESRGF------------------KVLYID 540
C A S+T+ G RQ D + L SR + V+Y D
Sbjct: 677 GLLPCLPLAASITSIGRDMLRQTSDFINNVLSSREYVSEKFGLSDGDFQGDFSLNVIYGD 736
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKY-ALID 598
TD ++ + E + +++S+L ++LE+E + + KK+Y +
Sbjct: 737 TDSVFVCVKNIVPERLAGICADISAHVSSQLFIEPIKLEFEKMFLPLMLICKKRYVGKMF 796
Query: 599 EEGKIVTRGLEIVRRD-----------------W-SEIAK---ETQAKVLEAILKHG--- 634
+ ++V +G+E+VR+ W SE+A+ E + ++++G
Sbjct: 797 DSDELVMKGVELVRKTSCPFVKNIVKEIVRLLFWDSEVARAAVELSQMSCDEVIRNGLPA 856
Query: 635 NVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV 693
+ + + I+ ++L ++ +LV+ +++ +S YK PH+ V +RL + +V
Sbjct: 857 GIHKIIDIIIGARDRLYTNKVDVNELVLSTMLSKEISMYKQPNLPHLRVIERLRNRNEEV 916
Query: 694 K-PGMVIGYIVL 704
G + Y+++
Sbjct: 917 PVVGDRVSYVLI 928
>gi|9628340 U38, DNA polymerase [Human herpesvirus 6]
>gi|118883|sp|P28857|DPOL_HSV6U DNA POLYMERASE
>gi|67044|pir||DJBE6S DNA-directed DNA polymerase (EC
2.7.7.7) - human herpesvirus 6 (strain U1102)
>gi|455196|gb|AAA74631.1| (M63804) DNA polymerase [Human
herpesvirus 6] >gi|854017|emb|CAA58372.1| (X83413) U38,
DNA polymerase [Human herpesvirus 6]
Length = 1012
Score = 152 bits (379), Expect = 2e-35
Identities = 168/671 (25%), Positives = 298/671 (44%), Gaps = 90/671 (13%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG---- 227
T + ID ++ +SE E++ +R + P+ I YN +NFD YL R +K+
Sbjct: 326 TCEKIDGVHIYEFASEFELLLGFFIFLRIESPEFITGYNINNFDLKYLCIRMDKIYHYDI 385
Query: 228 ---IKLPLGRDN-SEPKMQRMGDSLAVEIK----GRIHFDLFPVIRRTINLPTYTLEAVY 279
KL G+ S P Q L + K G ++ D++PV I Y L+ +
Sbjct: 386 GCFSKLKNGKIGISVPHEQYRKGFLQAQTKVFTSGVLYLDMYPVYSSKITAQNYKLDTIA 445
Query: 280 EAIFGKSKEKVYAHEIAEAWETG-KGLERVAKYSMEDAKVTFELGKEF-FPME-AQLARL 336
+ + KE++ EI + + +G G V KY ++D+ + L K+ + E A++ARL
Sbjct: 446 KICLQQEKEQLSYKEIPKKFISGPSGRAVVGKYCLQDSVLVVRLFKQINYHFEVAEVARL 505
Query: 337 VGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKG 396
V + +L +A RN + P+ R Y+G V EP+ G
Sbjct: 506 AHVTARCVVFEGQQKKIFPCILTEAKRRNMILPSMVSSHN---RQGIGYKGATVLEPKTG 562
Query: 397 LWE-GIVSLDFRSLYPSIIITHNVSPDTLNREN-----CKEYDVAP-QVG---HRFCKDF 446
+ V DF+SLYPSI++ HN+ TL + E D+ ++G HRF K
Sbjct: 563 YYAVPTVVFDFQSLYPSIMMAHNLCYSTLVLDERQIAGLSESDILTVKLGDETHRFVK-- 620
Query: 447 PGFIPSLLGNLLEE----RQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
P S+LG+LL++ R+++K M+ DP+ K LLD +Q A+K NS YG G A
Sbjct: 621 PCIRESVLGSLLKDWLAKRREVKAEMQNCSDPMMKLLLDKKQLALKTTCNSVYGVTGAAH 680
Query: 503 ARWYCKECAESVTAWGRQY----IDLVRRELESRGF------------------KVLYID 540
C A SVT GR+ +D V +++S F +V+Y D
Sbjct: 681 GLLPCVAIAASVTCLGREMLCSTVDYVNSKMQSEQFFCEEFGLTSSDFTGDLEVEVIYGD 740
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKYALIDE 599
TD ++ ++ ++ ++ A ++I +L ++LE+E + KK+Y +
Sbjct: 741 TDSIFMSVRNMVNQSLRRIAPMIAKHITDRLFKSPIKLEFEKILCPLILICKKRYIGRQD 800
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAV------------------- 640
+ ++ +G+++VR+ + K +++ + V A
Sbjct: 801 DSLLIFKGVDLVRKTSCDFVKGVVKDIVDLLFFDEEVQTAAVEFSHMTQTQLREQGVPVG 860
Query: 641 --KIVK---EVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV- 693
KI++ E E+L + L++ +++ ++ YK H++V +RLA + ++
Sbjct: 861 IHKILRRLCEAREELFQNRADVRHLMLSSVLSKEMAAYKQPNLAHLSVIRRLAQRKEEIP 920
Query: 694 KPGMVIGYIVLR---GDGPISKRAIAIEEFDPKKHK--YDAEYYIENQVLPAVERILRAF 748
G I Y+++ G+ +A + +HK AE Y + Q++ AV +
Sbjct: 921 NVGDRIMYVLIAPSIGNKQTHNYELAEDPNYVIEHKIPIHAEKYFD-QIIKAVTNAISPI 979
Query: 749 GYRKEDLKYQK 759
+ K D+K +K
Sbjct: 980 -FPKTDIKKEK 989
>gb|AAB67116.1| (AF013260) DNA-dependent DNA polymerase homolog [Feldmannia sp.
virus]
Length = 996
Score = 152 bits (379), Expect = 2e-35
Identities = 159/608 (26%), Positives = 267/608 (43%), Gaps = 64/608 (10%)
Query: 174 KSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE--------- 224
+S++ + V +E +++K+ +++ E+ +++ YN FD +L KRA
Sbjct: 231 ESVEGTPILCVQNELQLLKKFREIVVERQVCILVGYNSYQFDGQFLYKRAVDTYNYQDFC 290
Query: 225 KLGIKLPLGRDNSEPKMQRMGDSLAVE-------IKGRIHFDLFPVIRRTINLPTYTLEA 277
K+G L D + K + + S + I GR+ FD +RR L +Y L++
Sbjct: 291 KIGF---LRNDKASLKTKVLESSALGKNELSQFVIPGRVEFDALMTVRRNHKLGSYKLDS 347
Query: 278 VYEAIFGKSKEKVYAHEIAEAWETG--KGLERVAKYSMEDAKVTFELGKEFFPME--AQL 333
V FG K+ V I A E+ K L +AKY ++DA +T L + ++
Sbjct: 348 VCRHFFGGKKDDVSYEYILSACESKDPKKLGVIAKYCLQDAWLTLRLVSSLKDVYNGLEM 407
Query: 334 ARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEP 393
++L P+ + S G ++ L E NK R ++ ++G V +
Sbjct: 408 SKLCVVPLSYIE--SRGQQIKCLSLILDRVHGEFVCNKAS-RVLPGGVK--FQGATVIDA 462
Query: 394 EKGLW--EGIVSLDFRSLYPSIIITHNVSPDT---------LNRENCKEYDVAPQVGHRF 442
KG + +V LDF SLYPSII N+ T + + + ++++P V F
Sbjct: 463 TKGFHNKDPVVCLDFASLYPSIIRWKNLCYTTYLDSDEFANIPGVHYERFEISPGVYETF 522
Query: 443 CK--DFPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGY 500
G + ++ +L E R++ K MK KD + +LL+ +Q A K+ NS YG+ G
Sbjct: 523 ATRPGHKGILSAIEEDLGEARRQTKAAMKVEKDSKKLQLLNSKQLAQKVTMNSLYGFCGT 582
Query: 501 AKARWYCKECAESVTAWGRQYI----DLVRRELESRGFKVLYIDTDGLYATIPGAKHEEI 556
A +VT GR I D +R E+ G V+Y DTD + T P +
Sbjct: 583 VNGCLPLVAIAAAVTCTGRSMIKTTADFIRTEM---GGTVIYGDTDSVMCTFPAPQTVRG 639
Query: 557 KEK----------ALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALI-----DEEG 601
+ K L E S ++LEYE Y ++KK+YA + D E
Sbjct: 640 QGKRALLGHAYAMGLSAEEKSLSLFGHPVKLEYEKIYFPFLLISKKRYACMSYDRPDSEP 699
Query: 602 KIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV 661
K+ T GL VRRD +++ ++ V+ +++ + V+ VK V KL EI E L
Sbjct: 700 KMSTSGLVTVRRDNAKVVRDCANGVISILMEGRGQGDVVEYVKTVLSKLENSEIGVEDLT 759
Query: 662 IYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVK-PGMVIGYIVLRGDGPISKRAIAIEEF 720
I ++ + +Y H +A +L A+ K ++ +V +G P A + E
Sbjct: 760 ISNELKKHPDQYATPSAHSVLAGKLNARAKNQKLYREIVRPVVEQGGVPSLGTAYGVLEG 819
Query: 721 DPKKHKYD 728
+K +D
Sbjct: 820 VRRKFSFD 827
>pir||T43998 DNA polymerase [imported] - human herpesvirus 6 (strain HST)
>gi|4996026|dbj|BAA78259.1| (AB021506) DNA polymerase
[Human herpesvirus 6]
Length = 1012
Score = 152 bits (379), Expect = 2e-35
Identities = 169/671 (25%), Positives = 299/671 (44%), Gaps = 90/671 (13%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG---- 227
T + ID ++ +SE E++ +R + P+ I YN +NFD YL R +K+
Sbjct: 326 TCEQIDGVHIYEFASEFELLLGFFIFLRIESPEFITGYNINNFDLKYLCIRMDKIYHYEI 385
Query: 228 ---IKLPLGRDN-SEPKMQRMGDSLAVEIK----GRIHFDLFPVIRRTINLPTYTLEAVY 279
KL G+ S P Q L + K G ++ D++PV I Y L+ +
Sbjct: 386 GCFSKLKNGKIGISVPHEQYKKGFLQAQTKVFTSGVLYLDMYPVYSSKITAQNYKLDTIA 445
Query: 280 EAIFGKSKEKVYAHEIAEAWETG-KGLERVAKYSMEDAKVTFELGKE--FFPMEAQLARL 336
+ + KE++ EI + + +G G V KY ++D+ + L K+ + A++ARL
Sbjct: 446 KICLQQEKEQLSYKEIPKKFISGPSGRAVVGKYCLQDSVLVVRLFKQINYHYEVAEVARL 505
Query: 337 VGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKG 396
V + +L +A RN + P+ R Y+G V EP+ G
Sbjct: 506 AHVTARCVVFEGQQKKIFPCILTEAKRRNMILPSMVSSHN---RQGIGYKGATVLEPKTG 562
Query: 397 LWE-GIVSLDFRSLYPSIIITHNVSPDTLNREN-----CKEYDVAP-QVG---HRFCKDF 446
+ V DF+SLYPSI++ HN+ TL + E D+ ++G HRF K
Sbjct: 563 YYAVPTVVFDFQSLYPSIMMAHNLCYSTLVLDERQIAGLSESDILTVKLGDETHRFVK-- 620
Query: 447 PGFIPSLLGNLLEE----RQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
P S+LG+LL++ R+++K M+ DP+ K LLD +Q A+K NS YG G A
Sbjct: 621 PCVRESVLGSLLKDWLAKRREVKAEMQNCSDPMMKLLLDKKQLALKTTCNSVYGVTGAAH 680
Query: 503 ARWYCKECAESVTAWGRQY----IDLVRRELESRGF------------------KVLYID 540
C A SVT GR+ +D V +++S F +V+Y D
Sbjct: 681 GLLPCVAIAASVTCLGREMLCSTVDYVNSKMQSEQFFCEELGLTASDFTGDLKVEVIYGD 740
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKYALIDE 599
TD ++ ++ +E ++ A ++I +L ++LE+E + KK+Y +
Sbjct: 741 TDSIFMSVRNMANESLRRIAPMIAKHITDRLFKSPIKLEFEKILCPLILICKKRYIGRQD 800
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNV----------------DEAV--- 640
+ ++ +G+++VR+ + K +++ + V DE V
Sbjct: 801 DSLLIFKGVDLVRKTSCDFVKGVVKDIVDLLFFDEEVQTAAVEFSHMTQTQLRDEGVPVG 860
Query: 641 --KIVK---EVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV- 693
KI++ + E+L + L++ +++ ++ YK H++V +RLA + ++
Sbjct: 861 IHKILRRLCKAREELFQNRADVRHLMLSSVLSKEVAAYKQPNLAHLSVIRRLAQRKEEIP 920
Query: 694 KPGMVIGYIVL---RGDGPISKRAIAIEEFDPKKHK--YDAEYYIENQVLPAVERILRAF 748
G I Y+++ G+ +A + +HK AE Y + Q++ AV +
Sbjct: 921 NVGDRIMYVLIAPSTGNKQTHNYELAEDPNYVLEHKIPIHAEKYFD-QIIKAVTNAISPI 979
Query: 749 GYRKEDLKYQK 759
+ K D+K +K
Sbjct: 980 -FPKTDIKKEK 989
>gi|9625965 DNA polymerase [Saimiriine herpesvirus 2]
>gi|118886|sp|P24907|DPOL_HSVSA DNA POLYMERASE
>gi|67033|pir||DJBEM2 DNA-directed DNA polymerase (EC
2.7.7.7) - saimiriine herpesvirus 1 (strain 11)
>gi|60330|emb|CAA45632.1| (X64346) DNA polymerase
[Saimiriine herpesvirus 2] >gi|331057|gb|AAA46165.1|
(M31122) DNA polymerase [Saimiriine herpesvirus 2]
Length = 1009
Score = 151 bits (378), Expect = 2e-35
Identities = 152/602 (25%), Positives = 258/602 (42%), Gaps = 100/602 (16%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL-GIKL 230
T +++ V SE +M+ +IR+ + ++I YN NFD PYL+ RA ++ IKL
Sbjct: 331 TCSAVENTEVYEFPSEIDMLHGFFSLIRDFNVEIITGYNISNFDLPYLIDRATQIYNIKL 390
Query: 231 PLGRDNSEPKMQR--------------MGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLE 276
D S K M ++I G I D++ V + ++L Y L+
Sbjct: 391 S---DYSRVKTGSIFQVHTPKDTGNGFMRSVSKIKISGIIAIDMYIVCKDKLSLSNYKLD 447
Query: 277 AVYEAIFGKSKEKVYAHEIAEAWETG-KGLERVAKYSMEDAKVTFELGKEFFPME---AQ 332
V G KE V +I + +G +G ++ Y + D+ + +L K FF + ++
Sbjct: 448 TVANHCIGAKKEDVSYKDIMPLFMSGPEGRAKIGLYCVIDSVLVMKLLK-FFMIHVEISE 506
Query: 333 LARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKE 392
+A+L P V V LL A N + P D + ++G V
Sbjct: 507 IAKLAKIPTRRVLTDGQQIRVFSCLLAAARAENYILPVSNDVNA------DGFQGATVIN 560
Query: 393 PEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFI- 450
P G + ++ +DF SLYPSII HN+ TL + H D+ F+
Sbjct: 561 PIPGFYNNAVLVVDFASLYPSIIQAHNLCYSTLIPHHALH-----NYPHLKSSDYETFML 615
Query: 451 -------------PSLLGNLL----EERQKIKKRMKESKDPVEKKLLDYRQRAIKILANS 493
SLL LL +R+ I++++ E +D K +LD +Q AIK+ N+
Sbjct: 616 SSGPIHFVKKHIQASLLSRLLTVWLSKRKAIRQKLAECEDLDTKTILDKQQLAIKVTCNA 675
Query: 494 YYGYYGYAKARWYCKECAESVTAWGRQYID--------------------LVRRELESRG 533
YG+ G A C AE+VT GR ++ +V+ E +++
Sbjct: 676 VYGFTGVASGLLPCISIAETVTLQGRTMLEKSKIFIEAMTPDTLQEIVPHIVKHEPDAK- 734
Query: 534 FKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKK 592
F+V+Y DTD L+ G + + + + + KL ++LE E + + KK
Sbjct: 735 FRVIYGDTDSLFVECVGYSVDTVVKFGDFLAAFTSEKLFNAPIKLESEKTFQCLLLLAKK 794
Query: 593 KYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEA------------- 639
+Y I K++ +G+++VR+ + + T +K+L ILK V A
Sbjct: 795 RYIGILSNDKLLMKGVDLVRKTACKFVQNTSSKILNLILKDPEVKAAAQLLSTKDPDYAF 854
Query: 640 -----------VKIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLA 687
+ I+ E + L ++P E+L +++RP+S YK PH+ V K++
Sbjct: 855 REGLPDGFLKVIDILNESHKNLRTGQVPVEELTFSTELSRPISSYKTENLPHLTVYKKII 914
Query: 688 AK 689
+
Sbjct: 915 TR 916
>gi|9633109 U38 [Human herpesvirus 6B] >gi|11261521|pir||T44185 probable
DNA-directed DNA polymerase (EC 2.7.7.7) U38
[similarity] - human herpesvirus 6 (strain Z29)
>gi|5733549|gb|AAD49652.1|AF157706_49 (AF157706) U38
[Human herpesvirus 6B]
Length = 1012
Score = 151 bits (378), Expect = 2e-35
Identities = 167/671 (24%), Positives = 297/671 (43%), Gaps = 90/671 (13%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG---- 227
T + ID ++ +SE E++ +R + P+ I YN +NFD YL R +K+
Sbjct: 326 TCEQIDGVHIYEFASEFELLLGFFIFLRIESPEFITGYNINNFDLKYLCIRMDKIYHYEI 385
Query: 228 ---IKLPLGRDN-SEPKMQRMGDSLAVEIK----GRIHFDLFPVIRRTINLPTYTLEAVY 279
KL G+ S P Q L + K G ++ D++PV I Y L+ +
Sbjct: 386 GCFSKLKNGKIGISVPHEQYKKGFLQAQTKVFTSGVLYLDMYPVYSSKITAQNYKLDTIA 445
Query: 280 EAIFGKSKEKVYAHEIAEAWETG-KGLERVAKYSMEDAKVTFELGKE--FFPMEAQLARL 336
+ + KE++ EI + + +G G V KY ++D+ + L K+ + A++ARL
Sbjct: 446 KICLQQEKEQLSYKEIPKKFISGPSGRAVVGKYCLQDSVLVVRLFKQINYHYEVAEVARL 505
Query: 337 VGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKG 396
V + +L +A RN + P+ R Y+G V EP+ G
Sbjct: 506 AHVTARCVVFEGQQKKIFPCILTEAKRRNMILPSMVSSHN---RQGIGYKGATVLEPKTG 562
Query: 397 LWE-GIVSLDFRSLYPSIIITHNVSPDTLNREN-----CKEYDVAP-QVG---HRFCKDF 446
+ V DF+SLYPSI++ HN+ TL + E D+ ++G HRF K
Sbjct: 563 YYAVPTVVFDFQSLYPSIMMAHNLCYSTLVLDERQIAGLSESDILTVKLGDETHRFVK-- 620
Query: 447 PGFIPSLLGNLLEE----RQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
P S+LG+LL++ R+++K M+ DP+ K LLD +Q A+K NS YG G A
Sbjct: 621 PCVRESVLGSLLKDWLAKRREVKAEMQNCSDPMMKLLLDKKQLALKTTCNSVYGVTGAAH 680
Query: 503 ARWYCKECAESVTAWGRQY----IDLVRRELESRGF------------------KVLYID 540
C A SVT GR+ +D V +++S F +V+Y D
Sbjct: 681 GLLPCVAIAASVTCLGREMLCSTVDYVNSKMQSEQFFCEELGLTASDFTGDLKVEVIYGD 740
Query: 541 TDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKYALIDE 599
TD ++ ++ +E ++ A ++I +L ++LE+E + KK+Y +
Sbjct: 741 TDSIFMSVRNMANESLRRIAPMIAKHITDRLFKSPIKLEFEKILCPLILICKKRYIGRQD 800
Query: 600 EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAV------------------- 640
+ ++ +G+++VR+ + K +++ + V A
Sbjct: 801 DSLLIFKGVDLVRKTSCDFVKGVVKDIVDLLFFDEEVQTAAVEFSHMTQTQLREQGVPVG 860
Query: 641 --KIVK---EVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV- 693
KI++ + E+L + L++ +++ ++ YK H++V +RLA + ++
Sbjct: 861 IHKILRRLCKAREELFQNRADVRHLMLSSVLSKEVAAYKQPNLAHLSVIRRLAQRKEEIP 920
Query: 694 KPGMVIGYIVL---RGDGPISKRAIAIEEFDPKKHK--YDAEYYIENQVLPAVERILRAF 748
G I Y+++ G+ +A + +HK AE Y + Q++ AV +
Sbjct: 921 NVGDRIMYVLIAPSTGNKQTHNYELAEDPNYVLEHKIPIHAEKYFD-QIIKAVTNAISPI 979
Query: 749 GYRKEDLKYQK 759
+ K D+K +K
Sbjct: 980 -FPKTDIKKEK 989
>gi|9628761 DNA polymerase [Human herpesvirus 7]
>gi|1706511|sp|P52342|DPOL_HSV7J DNA POLYMERASE
>gi|7514771|pir||T41940 DNA polymerase - human
herpesvirus 7 (strain JI) >gi|1139640|gb|AAC54700.1|
(U43400) DNA polymerase [Human herpesvirus 7]
Length = 1012
Score = 150 bits (376), Expect = 4e-35
Identities = 178/714 (24%), Positives = 303/714 (41%), Gaps = 107/714 (14%)
Query: 141 DIETLYHEG-----EEFGKGPIIMISYADEEGA-------KVITWKSIDLPYVEVVSSER 188
DIE L G E+ +I + D EG + T + I+ ++ +SE
Sbjct: 281 DIECLSQNGNFPDAEQMVTSSLISVIDFDSEGNYQSKHLFTLGTCEQIEGVFIYEFASEF 340
Query: 189 EMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG-------IKLPLGRDNS---- 237
E++ ++ K P+++ YN NFD YL R EK+ KL G+ +
Sbjct: 341 ELLYAFFLFLKCKSPEILTGYNIINFDLKYLCTRMEKIYNFEIGGFSKLKRGKFSVIVPY 400
Query: 238 EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAE 297
E + + V + G + FD++ V I+ Y L+ + + + KE + EI +
Sbjct: 401 EQHKKFLNSLTKVNMSGILCFDMYNVYSSKISAQNYKLDTIAKLCLNQEKENLSYKEIPK 460
Query: 298 AWETG-KGLERVAKYSMEDAKVTFELGKE--FFPMEAQLARLVGQPVWDVSRSSTGNLVE 354
+ G KG V +Y ++D+ + +L + + A++A L + +
Sbjct: 461 KFIDGSKGRAVVGRYCIQDSLLVVQLFTKINYHYEMAEVASLAYITIRCAVFEGQQKKIF 520
Query: 355 WFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRSLYPSI 413
+L +A N + P+ + + + Y+G V EP+ G + V DF+SLYPSI
Sbjct: 521 PCILHEAKNLNMILPSM-NTNFNKGKENVGYKGATVLEPKIGYYATPTVVFDFQSLYPSI 579
Query: 414 IITHNVSPDTL----------NRENCKEYDVAPQVGHRFCKDF--PGFIPSLLGNLLEER 461
++ HN+ TL + ++ V P V HRF K + SLL L++R
Sbjct: 580 MMAHNLCYSTLVVDENAVIGLHADDILTVHVGP-VTHRFVKKTVRESILASLLKKWLDKR 638
Query: 462 QKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQ- 520
+++K +MK +PV + LLD +Q A+K NS YG G + C A SVT GR+
Sbjct: 639 KEVKMQMKMCNNPVMEMLLDKKQLALKTTCNSVYGVTGATHSLLPCVAIAASVTCLGREM 698
Query: 521 ------YID--------------LVRRELESR-GFKVLYIDTDGLYATIPGAKHEEIKEK 559
Y+D L R + G +V+Y DTD L+ T + +K
Sbjct: 699 LCKTVDYVDSAMYSDTFFIEKFGLTRGDFSGTFGIEVIYGDTDSLFVTFKNVCPKALKRI 758
Query: 560 ALKFVEYI-NSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRR----- 613
A +I N+ ++LE+E + KK+Y ++ +V +G+E+VR+
Sbjct: 759 APSIASHITNTLFKHPIKLEFEKILFPLILICKKRYIGKLDDATLVFKGVELVRKTSCDF 818
Query: 614 ----------------DWSEIAKETQAKVLEAILKHGNVDEAVKIVK---EVTEKLSKYE 654
D + A++ ++ I ++G D KI+K + + L
Sbjct: 819 VKVVVKDIIDLLFWDVDVQKSAEKLSNMTIQEIYENGVPDGIQKIIKKLCDARDALFLNR 878
Query: 655 IPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV-KPGMVIGYIVLRGDGPISK 712
+ + LV+ +++ +S YK PH+AV KRLA + ++ G + YI++ + K
Sbjct: 879 VNIKSLVLSSVLSKDISAYKQANLPHLAVVKRLAQRKEELPNIGDRVMYILIAPTETVKK 938
Query: 713 R----------AIAIEEFDPKKHKYDAEYYIE---NQVLPAVERILRAFGYRKE 753
A AIE K +A+ Y E V A+ I G +KE
Sbjct: 939 TFHNYELAEDPAYAIE----NNLKINADKYFEQIMKAVTNAISPIFPKTGIKKE 988
>gi|6325090 DNA polymerase zeta subunit; Rev3p [Saccharomyces cerevisiae]
>gi|118901|sp|P14284|DPOZ_YEAST DNA POLYMERASE ZETA
CATALYTIC SUBUNIT >gi|101557|pir||A33602 DNA-directed DNA
polymerase (EC 2.7.7.7) REV3 - yeast (Saccharomyces
cerevisiae) >gi|172387|gb|AAA34968.1| (M29683) DNA
polymerase (pot.); putative [Saccharomyces cerevisiae]
>gi|1370353|emb|CAA97873.1| (Z73523) ORF YPL167c
[Saccharomyces cerevisiae] >gi|1403542|emb|CAA65554.1|
(X96770) P2535 protein [Saccharomyces cerevisiae]
Length = 1504
Score = 150 bits (376), Expect = 4e-35
Identities = 156/627 (24%), Positives = 280/627 (43%), Gaps = 70/627 (11%)
Query: 186 SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQ--- 242
SE EM + L ++ DPD++ + NF + Y+++R +K+ + + R+ + K Q
Sbjct: 744 SEFEMFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIH-QFDIVRELARVKCQIKT 802
Query: 243 RMGD------SLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIA 296
++ D S + I GR +++ +R +NL YT+E+ I K +
Sbjct: 803 KLSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTIESAAFNILHKRLPHFSFESLT 862
Query: 297 EAWETGKG---LERVAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVSRSSTGN 351
W K L+ V Y + A++ +L +++ + ARL+G V +
Sbjct: 863 NMWNAKKSTTELKTVLNYWLSRAQINIQLLRKQDYIARNIEQARLIGIDFHSVYYRGSQF 922
Query: 352 LVEWFLLR--KAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLDFRS 408
VE FL+R K+ L+P K D R+ ++ E V EPE ++ ++ LDF+S
Sbjct: 923 KVESFLIRICKSESFILLSPGKKDVRK--QKALECVP--LVMEPESAFYKSPLIVLDFQS 978
Query: 409 LYPSIIITHNVSPDT---------LNRENC----------------KEYDVAPQVGHRFC 443
LYPSI+I +N T L N + +AP G +
Sbjct: 979 LYPSIMIGYNYCYSTMIGRVREINLTENNLGVSKFSLPRNILALLKNDVTIAPN-GVVYA 1037
Query: 444 KDF--PGFIPSLLGNLLEERQKIKKRMKESKDP--VEKKLLDYRQRAIKILANSYYGYYG 499
K + +L ++L+ R IKK M E D K+LL+ +Q A+K+LAN YGY
Sbjct: 1038 KTSVRKSTLSKMLTDILDVRVMIKKTMNEIGDDNTTLKRLLNNKQLALKLLANVTYGYTS 1097
Query: 500 YA-KARWYCKECAESVTAWGRQY----IDLVRRELESRGFKVLYIDTDGLYATIPGAKHE 554
+ R C + A+S+ GR+ ID++ ++ E+ KV+Y DTD L+ +PG
Sbjct: 1098 ASFSGRMPCSDLADSIVQTGRETLEKAIDIIEKD-ETWNAKVVYGDTDSLFVYLPGKTAI 1156
Query: 555 EIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKIVT------RGL 608
E E + P + L++E Y ++KK+Y E T +G+
Sbjct: 1157 EAFSIGHAMAERVTQNNPKPIFLKFEKVYHPSILISKKRYVGFSYESPSQTLPIFDAKGI 1216
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITR 668
E VRRD ++ K + + + ++ + K ++ K+ ++ + +++
Sbjct: 1217 ETVRRDGIPAQQKIIEKCIRLLFQTKDLSKIKKYLQNEFFKIQIGKVSAQDFCFAKEVKL 1276
Query: 669 PLSEYKAIGPHVA-VAKRLAAKGVKVKPGMV--IGYIVLRGDGP--ISKRAIAIEEF-DP 722
+ + P A V KR + + +P I Y+V++G + +R ++ EEF +
Sbjct: 1277 GAYKSEKTAPAGAVVVKRRINEDHRAEPQYKERIPYLVVKGKQGQLLRERCVSPEEFLEG 1336
Query: 723 KKHKYDAEYYIENQVLPAVERILRAFG 749
+ + D+EYYI ++P ++R+ G
Sbjct: 1337 ENLELDSEYYINKILIPPLDRLFNLIG 1363
>sp|P27172|DPOL_MCMVS DNA POLYMERASE >gi|67043|pir||DJBEMC DNA-directed DNA polymerase (EC
2.7.7.7) - murine cytomegalovirus (strain Smith)
>gi|330518|gb|AAA45940.1| (M73549) DNA polymerase [Mouse
cytomegalovirus 1]
Length = 1097
Score = 149 bits (372), Expect = 1e-34
Identities = 175/678 (25%), Positives = 286/678 (41%), Gaps = 114/678 (16%)
Query: 178 LPYVEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD 235
+P V++ + SE EM++ + P+ I YN + FD Y+L RAEKL K+ +G+
Sbjct: 355 IPDVKIYTFPSEYEMLRGFFIFLSWYSPEFITGYNINGFDIKYILTRAEKL-YKMDVGQF 413
Query: 236 NSEPKMQRM------------GDSLAVEI--KGRIHFDLFPVIRRTINLPTYTLEAVYEA 281
+ RM G S V++ G + D++PV + P Y L+ + E
Sbjct: 414 TKLRRGGRMFVFSPEKGKAGFGTSNTVKVFWSGTVVLDMYPVCTAKASSPNYKLDTMAEI 473
Query: 282 IFGKSKEKVYAHEIAEAWETG-KGLERVAKYSMEDAKVTFELGK--EFFPMEAQLARLVG 338
K K+ + EI + G +G KY ++DA + EL + F A +ARL
Sbjct: 474 YLKKKKDDLSYKEIPVQFSAGDEGRAPGGKYCLQDAVLVRELFEMLAFHFEAAAIARLAR 533
Query: 339 QPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPD----------------------ERE 376
P+ V + LL + R+ + PN P E E
Sbjct: 534 IPLRKVIFDGQQIRIYTCLLEECSGRDMILPNMPSLGHGAAAAIEEAAAGGEGDETSEGE 593
Query: 377 YERRLRE-SYEGGYVKEPEKGLWEGIVSL-DFRSLYPSIIITHNVSPDTLNRENCKEYD- 433
R Y+G V EPE G V + DF SLYPSII+++N+ TL E E
Sbjct: 594 NSNNSRTVGYQGATVLEPECGFHHVPVCVFDFASLYPSIIMSNNLCYSTLLVEGSPEVPE 653
Query: 434 ---VAPQVG---HRFCKD--FPGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQR 485
+ ++G HRF ++ + LL L +R+ +++ MK+ + +++ ++D +Q
Sbjct: 654 KDVLRVEIGDQCHRFVRENVHRSLLAELLVRWLTQRKLVREAMKQCTNEMQRMIMDKQQL 713
Query: 486 AIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYI--------------DLVRREL-- 529
A+K+ N++YG+ G A C A S+T GR + D +R L
Sbjct: 714 ALKVTCNAFYGFTGVAAGMLPCLPIAASITKIGRDMLLATAGHIEDRCNRPDFLRTVLGL 773
Query: 530 -------ESRGFKVLYIDTDGLYATIPGAKHEE-IKEKALKFVEYINSKLPGLLELEYEG 581
E+ K++Y DTD ++A G E +K N+ + LE+E
Sbjct: 774 PPEAIDPEALRVKIIYGDTDSVFAAFYGIDKEALLKAVGALAANVTNALFKEPVRLEFEK 833
Query: 582 FYARGFFVTKKKY-ALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDE-A 639
+ + KK+Y + + +G+++VRR K + VL + V E
Sbjct: 834 MFVSLMMICKKRYIGKVHGSQNLSMKGVDLVRRTACGFVKAVVSDVLHMVFNDETVSEGT 893
Query: 640 VKIVKEVTEKLSKYEIPPE-----------------------KLVIYEQITRPLSEYKAI 676
+K+ + + L K IP E +L + +++ LS YK
Sbjct: 894 MKLSRMTFDDLKKNGIPCEFGPVVSRLCRARDDLHLKKVPVPELTLSSVLSQELSCYKQK 953
Query: 677 G-PHVAVAKRLAAKGVKVKP-GMVIGYIVLRGDGPISKRAIAIEEF--DPK-----KHKY 727
PH+AV +RLAA+ ++ G + Y++ DG K+ + E DP+ K
Sbjct: 954 NLPHLAVIRRLAARKEELPAVGDRVEYVLTLPDG--CKKNVPNYEIAEDPRHVVEAKLSI 1011
Query: 728 DAEYYIENQVLPAVERIL 745
+AE Y E QV+ AV L
Sbjct: 1012 NAEKYYE-QVVKAVTNTL 1028
>gb|AAC40752.1| (AF037218) catalytic subunit of replicative DNA polymerase [Human
herpesvirus 7]
Length = 1013
Score = 148 bits (370), Expect = 2e-34
Identities = 167/671 (24%), Positives = 289/671 (42%), Gaps = 95/671 (14%)
Query: 172 TWKSIDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG---- 227
T + I+ ++ +SE E++ ++ K P+++ YN NFD YL R EK+
Sbjct: 325 TCEQIEGVFIYEFASEFELLYAFFLFLKCKSPEILTGYNIINFDLKYLCTRMEKIYNFEI 384
Query: 228 ---IKLPLGRDNS----EPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYE 280
KL G+ + E + + V + G + FD++ V I+ Y L+ + +
Sbjct: 385 GGFSKLKRGKFSVIVPYEQHKKFLNSLTKVNMSGILCFDMYNVYSSKISAQNYKLDTIAK 444
Query: 281 AIFGKSKEKVYAHEIAEAWETG-KGLERVAKYSMEDAKVTFELGKE--FFPMEAQLARLV 337
+ K+ + EI + + G KG V +Y ++D+ + +L + + A++A L
Sbjct: 445 LCLNQEKKNLSYKEIPKKFIDGSKGRAVVGRYCIQDSLLVVQLFTKINYHYEMAEVASLA 504
Query: 338 GQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGL 397
+ + +L +A N + P+ + + + Y+G V EP+ G
Sbjct: 505 YITIRCAVFEGQQKKIFPCILHEAKNLNMILPSM-NTNFNKGKENVGYKGATVLEPKIGY 563
Query: 398 WEG-IVSLDFRSLYPSIIITHNVSPDTL----------NRENCKEYDVAPQVGHRFCKDF 446
+ V DF+SLYPSI++ HN+ TL + ++ V P V HRF K
Sbjct: 564 YATPTVVFDFQSLYPSIMMAHNLCYSTLVVDENAVIGLHADDILTVHVGP-VTHRFVKKT 622
Query: 447 --PGFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKAR 504
+ SLL L++R+++K +MK +PV + LLD +Q A+K NS YG G +
Sbjct: 623 VRESILASLLKKWLDKRKEVKMQMKMCNNPVMEMLLDKKQLALKTTCNSVYGVTGATHSL 682
Query: 505 WYCKECAESVTAWGRQ-------YID--------------LVRRELESR-GFKVLYIDTD 542
C A SVT GR+ Y+D L R + G +V+Y DTD
Sbjct: 683 LPCVAIAASVTCLGREMLCKTVDYVDSAMYSDTFFIEKFGLTRGDFSGTFGIEVIYGDTD 742
Query: 543 GLYATIPGAKHEEIKEKALKFVEYI-NSKLPGLLELEYEGFYARGFFVTKKKYALIDEEG 601
L+ T + +K A +I N+ ++LE+E + KK+Y ++
Sbjct: 743 SLFVTFKNVCPKALKRIAPSIASHITNTLFKHPIKLEFEKILFPLILICKKRYIGKLDDA 802
Query: 602 KIVTRGLEIVRR---------------------DWSEIAKETQAKVLEAILKHGNVDEAV 640
+V +G+E+VR+ D + A++ ++ I ++G D
Sbjct: 803 TLVFKGVELVRKTSCDFVKVVVKDIIDLLFWDVDVQKSAEKLSNMTIQEIYENGVPDGIQ 862
Query: 641 KIVK---EVTEKLSKYEIPPEKLVIYEQITRPLSEYKAIG-PHVAVAKRLAAKGVKV-KP 695
KI+K + + L + + LV+ +++ +S YK PH+AV KRLA + ++
Sbjct: 863 KIIKKLCDARDALFLNRVNIKSLVLSSVLSKDISAYKQANLPHLAVVKRLAQRKEELPNI 922
Query: 696 GMVIGYIVLRGDGPISKR----------AIAIEEFDPKKHKYDAEYYIE---NQVLPAVE 742
G + YI++ + K A AIE K +A+ Y E V A+
Sbjct: 923 GDRVMYILIAPTETVKKTFHNYELAEDPAYAIE----NNLKINADKYFEQIMKAVTNAIS 978
Query: 743 RILRAFGYRKE 753
I G +KE
Sbjct: 979 PIFPKTGIKKE 989
>pir||T02155 DNA-directed DNA polymerase homolog T1F15.3 - Arabidopsis thaliana
>gi|3176661|gb|AAC18785.1| (AC004393) Similar to putative
DNA polymerase gb|M29683 from S. cerevisiae. [Arabidopsis
thaliana]
Length = 1894
Score = 142 bits (354), Expect = 2e-32
Identities = 145/654 (22%), Positives = 276/654 (42%), Gaps = 88/654 (13%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL---------P 231
+ V ER++ + ++ + + DPDV++ ++ +L +RA +LGI+ P
Sbjct: 1101 LSVFLEERQLFRYFIETLCKWDPDVLLGWDIQGGSIGFLAERAAQLGIRFLNNISRTPSP 1160
Query: 232 LGRDNSEPKMQRMGDSL---------------------------AVEIKGRIHFDLFPVI 264
+NS+ K +++G++L V + GRI + + +I
Sbjct: 1161 TTTNNSDNK-RKLGNNLLPDPLVANPAQVEEVVIEDEWGRTHASGVHVGGRIVLNAWRLI 1219
Query: 265 RRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGK--GLERVAKYSMEDAKVTFEL 322
R + L YT+EAV EA+ + + + E + +G R +Y + A + E+
Sbjct: 1220 RGEVKLNMYTIEAVSEAVLRQKVPSIPYKVLTEWFSSGPAGARYRCIEYVIRRANLNLEI 1279
Query: 323 GK--EFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERR 380
+ ++LAR+ G + V + VE LLR A+ +N LA + +++ +
Sbjct: 1280 MSQLDMINRTSELARVFGIDFFSVLSRGSQYRVESMLLRLAHTQNYLAISPGNQQVASQP 1339
Query: 381 LRESYEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHN-------------------VS 420
E V EPE ++ ++ LDF+SLYPS+II +N VS
Sbjct: 1340 AMECVP--LVMEPESAFYDDPVIVLDFQSLYPSMIIAYNLCFSTCLGKLAHLKMNTLGVS 1397
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFP----GFIPSLLGNLLEERQKIKKRMKE--SKDP 474
+L+ + ++ + Q + P G +P LL +L R +KK MK+ +
Sbjct: 1398 SYSLDLDVLQDLNQILQTPNSVMYVPPEVRRGILPRLLEEILSTRIMVKKAMKKLTPSEA 1457
Query: 475 VEKKLLDYRQRAIKILANSYYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRRELESR- 532
V ++ + RQ A+K++AN YGY R C E A+S+ GR ++ + +
Sbjct: 1458 VLHRIFNARQLALKLIANVTYGYTAAGFSGRMPCAELADSIVQCGRSTLEKAISFVNAND 1517
Query: 533 --GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVT 590
+V+Y DTD ++ + G +E + I P + L+ E Y F +T
Sbjct: 1518 NWNARVVYGDTDSMFVLLKGRTVKEAFVVGQEIASAITEMNPHPVTLKMEKVYHPCFLLT 1577
Query: 591 KKKYALIDEEGK------IVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVK 644
KK+Y E +G+E VRRD E +T + L + N+ + +
Sbjct: 1578 KKRYVGYSYESPNQREPIFDAKGIETVRRDTCEAVAKTMEQSLRLFFEQKNISKVKSYLY 1637
Query: 645 EVTEKLSKYEIPPEKLVIYEQI---TRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMV--I 699
+++ + + + +++ T + + P VA + + +P +
Sbjct: 1638 RQWKRILSGRVSLQDFIFAKEVRLGTYSTRDSSLLPPAAIVATKSMKADPRTEPRYAERV 1697
Query: 700 GYIVLRGDGPISKRAIAIEEF----DPKKHKYDAEYYIENQVLPAVERILRAFG 749
Y+V+ G+ + ++ ++ + YYI Q++PA++R+ G
Sbjct: 1698 PYVVIHGEPGARLVDMVVDPLVLLDVDTPYRLNDLYYINKQIIPALQRVFGLVG 1751
>gb|AAF07803.1|AC011020_3 (AC011020) putative DNA polymerase zeta catalytic subunit
[Arabidopsis thaliana]
Length = 1871
Score = 142 bits (354), Expect = 2e-32
Identities = 145/654 (22%), Positives = 276/654 (42%), Gaps = 88/654 (13%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL---------P 231
+ V ER++ + ++ + + DPDV++ ++ +L +RA +LGI+ P
Sbjct: 1101 LSVFLEERQLFRYFIETLCKWDPDVLLGWDIQGGSIGFLAERAAQLGIRFLNNISRTPSP 1160
Query: 232 LGRDNSEPKMQRMGDSL---------------------------AVEIKGRIHFDLFPVI 264
+NS+ K +++G++L V + GRI + + +I
Sbjct: 1161 TTTNNSDNK-RKLGNNLLPDPLVANPAQVEEVVIEDEWGRTHASGVHVGGRIVLNAWRLI 1219
Query: 265 RRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETGK--GLERVAKYSMEDAKVTFEL 322
R + L YT+EAV EA+ + + + E + +G R +Y + A + E+
Sbjct: 1220 RGEVKLNMYTIEAVSEAVLRQKVPSIPYKVLTEWFSSGPAGARYRCIEYVIRRANLNLEI 1279
Query: 323 GK--EFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERR 380
+ ++LAR+ G + V + VE LLR A+ +N LA + +++ +
Sbjct: 1280 MSQLDMINRTSELARVFGIDFFSVLSRGSQYRVESMLLRLAHTQNYLAISPGNQQVASQP 1339
Query: 381 LRESYEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHN-------------------VS 420
E V EPE ++ ++ LDF+SLYPS+II +N VS
Sbjct: 1340 AMECVP--LVMEPESAFYDDPVIVLDFQSLYPSMIIAYNLCFSTCLGKLAHLKMNTLGVS 1397
Query: 421 PDTLNRENCKEYDVAPQVGHRFCKDFP----GFIPSLLGNLLEERQKIKKRMKE--SKDP 474
+L+ + ++ + Q + P G +P LL +L R +KK MK+ +
Sbjct: 1398 SYSLDLDVLQDLNQILQTPNSVMYVPPEVRRGILPRLLEEILSTRIMVKKAMKKLTPSEA 1457
Query: 475 VEKKLLDYRQRAIKILANSYYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRRELESR- 532
V ++ + RQ A+K++AN YGY R C E A+S+ GR ++ + +
Sbjct: 1458 VLHRIFNARQLALKLIANVTYGYTAAGFSGRMPCAELADSIVQCGRSTLEKAISFVNAND 1517
Query: 533 --GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVT 590
+V+Y DTD ++ + G +E + I P + L+ E Y F +T
Sbjct: 1518 NWNARVVYGDTDSMFVLLKGRTVKEAFVVGQEIASAITEMNPHPVTLKMEKVYHPCFLLT 1577
Query: 591 KKKYALIDEEGK------IVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVK 644
KK+Y E +G+E VRRD E +T + L + N+ + +
Sbjct: 1578 KKRYVGYSYESPNQREPIFDAKGIETVRRDTCEAVAKTMEQSLRLFFEQKNISKVKSYLY 1637
Query: 645 EVTEKLSKYEIPPEKLVIYEQI---TRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMV--I 699
+++ + + + +++ T + + P VA + + +P +
Sbjct: 1638 RQWKRILSGRVSLQDFIFAKEVRLGTYSTRDSSLLPPAAIVATKSMKADPRTEPRYAERV 1697
Query: 700 GYIVLRGDGPISKRAIAIEEF----DPKKHKYDAEYYIENQVLPAVERILRAFG 749
Y+V+ G+ + ++ ++ + YYI Q++PA++R+ G
Sbjct: 1698 PYVVIHGEPGARLVDMVVDPLVLLDVDTPYRLNDLYYINKQIIPALQRVFGLVG 1751
>gb|AAF63493.1|AF239684_1 (AF239684) polymerase [green turtle herpesvirus]
Length = 673
Score = 141 bits (353), Expect = 2e-32
Identities = 147/565 (26%), Positives = 241/565 (42%), Gaps = 94/565 (16%)
Query: 164 DEEGAKVITWKSIDLPYVEVVS-------SEREMIKRLVKVIREKDPDVIITYNGDNFDF 216
+EEG + + S LP S SE E++ ++ P+ YN FD
Sbjct: 28 NEEGRLLFSLGSCRLPAEAAGSATVIECDSEYELLLAFFTFFKQFSPEYPSGYNILGFDL 87
Query: 217 PYLLKRAEKLGIKLP-LGR----------DNSEPKMQRMGDSLAVEIKGRIHFDLFPVIR 265
P+L+ +A +KL GR D SE + Q+ ++ V I G + D++P++R
Sbjct: 88 PFLVNKAAAYDLKLDGYGRLERGGQFRIIDLSENRFQK---NIKVRINGTVTLDVYPLLR 144
Query: 266 RTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEAWETG-KGLERVAKYSMEDAKVTFELGK 324
++LP Y L+ V + G++K V EI + G +G + Y ++D+ + L +
Sbjct: 145 GKLSLPDYKLDTVCREVLGETKRDVSYKEIPALYGQGPEGRGLLGDYCLQDSALVLRLFE 204
Query: 325 EFFPMEAQLARLVGQPVWDVSRSST-GNLVEWF--LLRKAYERNELAP------------ 369
+F P +++ + + ++R T G + F LL+ A + + P
Sbjct: 205 KFAP-HVEMSEVANWRICLMNRVMTDGQQIRVFTCLLKAARKYGYILPDRRFGTKAQLTD 263
Query: 370 -------NKPDEREYERRLRES--------YEGGYVKEPEKGLW-EGIVSLDFRSLYPSI 413
N P+E E E+ Y+G V EPE G + + + DF SLYPSI
Sbjct: 264 PDLSPSLNGPEEGTEEENETENGAYTGDKGYQGATVLEPETGFYVDPVTVFDFASLYPSI 323
Query: 414 IITHNVSPDTLNR--ENCKE------YDVAPQVGHRFCKDFPGFIPSLLGNLLEE----R 461
I HN+ TL R E KE Y+ G P SLLG LL + R
Sbjct: 324 IQAHNLCFTTLTRRAETLKELKAGEDYEEFKVQGMSLFYVKPHVRRSLLGELLTDWLALR 383
Query: 462 QKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQY 521
+KI+ MK + ++ LLD +Q AIK+ NS YG+ G A C E A +VT GR
Sbjct: 384 KKIRASMKTAPSD-QRLLLDKQQLAIKLTCNSVYGFTGVATGFLPCLEVAATVTTVGRDM 442
Query: 522 IDLVRRELESR-------------------------GFKVLYIDTDGLYATIPGAKHEEI 556
+ R + +R G +V+Y DTD ++ G E +
Sbjct: 443 LLATRDFIHTRWGTDFEALLVDAPELAAFRRPESLFGLRVIYGDTDSVFVLCTGVTAEGL 502
Query: 557 KEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKY-ALIDEEGKIVTRGLEIVRRD 614
I+ L ++LE E + + +TKKKY +I +++ +G+++VR++
Sbjct: 503 ALHGDVLAAVISRALFSAPIKLECEKTFHKLLMITKKKYIGVIQGSNQMMMKGVDLVRKN 562
Query: 615 WSEIAKETQAKVLEAILKHGNVDEA 639
+++ + K+ V A
Sbjct: 563 NCRFVNRYSRDLVDCLFKNDEVSRA 587
>gb|AAG30224.1| (AF298216) DNA polymerase zeta catalytic subunit [Drosophila
melanogaster]
Length = 2130
Score = 133 bits (332), Expect = 6e-30
Identities = 160/635 (25%), Positives = 273/635 (42%), Gaps = 65/635 (10%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-PL------- 232
V+VV+SE E + L+ + D D+ Y + + Y++ RA+ L + PL
Sbjct: 1371 VQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQ 1430
Query: 233 -GRDNSEPKMQRMGDSLAVEIK--GRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
RD + ++ D L VE+K GRI D++ ++R I L +YT E V I K
Sbjct: 1431 KVRDFVDEDREQFTD-LDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPW 1489
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVSRS 347
A + E + + V +Y +E + T L + +++A+L+G ++V
Sbjct: 1490 HTAKSLTEWFGSPCTRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSR 1549
Query: 348 STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-EGIVSLDF 406
+ VE +LR A +N L P P + Y + EP+ + + ++ LDF
Sbjct: 1550 GSQFRVESMMLRIAKPKN-LVPLSPSVQARAHMRAPEYLA-LIMEPQSRFYADPLIVLDF 1607
Query: 407 RSLYPSIIITHNVSPDT-LNR------------------------ENCKEYDVAP--QVG 439
+SLYPS+II +N T L R + E+D+ G
Sbjct: 1608 QSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCG 1667
Query: 440 HRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVE-KKLLDYRQRAIKILANSYYG 496
F K G +P +L +L+ RQ +K+ MK KD +++L RQ +K++AN YG
Sbjct: 1668 VVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYG 1727
Query: 497 YYGYA-KARWYCKECAESVTAWGRQYIDLVRRELESRG---FKVLYIDTDGLYATIPGAK 552
Y R E +SV + GR+ ++ + +E+ +V+Y DTD ++ +PG
Sbjct: 1728 YTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRN 1787
Query: 553 HEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV-TR 606
E + + + P ++L+ E Y TKK+Y D+E + +
Sbjct: 1788 RAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAK 1847
Query: 607 GLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQI 666
G+E VRRD + KVL + + +V + V KL + L+ ++
Sbjct: 1848 GIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEF 1907
Query: 667 TRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFD- 721
R L+ YK A P + + ++ K + P G + +I++ G + + D
Sbjct: 1908 -RGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDI 1966
Query: 722 --PKKHKYDAEYYIENQVLPAVERILRAFGYRKED 754
+ HK +A YYI ++P + R L G D
Sbjct: 1967 LANEGHKINAIYYITKAIIPPLNRCLLLIGANVHD 2001
>gb|AAB88486.1| (AF035537) DNA polymerase zeta [Homo sapiens]
Length = 3052
Score = 132 bits (330), Expect = 1e-29
Identities = 145/636 (22%), Positives = 270/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + +I+ DPD+++ Y + YLL+RA L I L + D
Sbjct: 2298 VTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDD 2357
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2358 KIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQ-RFP 2416
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2417 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2474
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2475 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVP--LIMEPESRFYSNSV 2532
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2533 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVS 2592
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++LD RQ +K++AN
Sbjct: 2593 PNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANV 2652
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2653 TFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2712
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV 604
GA E+ + + E + + P ++L++E Y TKK+Y +D++ +
Sbjct: 2713 GATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVF 2772
Query: 605 -TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ ++ + + +
Sbjct: 2773 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLEGKASIQD 2828
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIA 716
I+ + R YK A P + + +++ + +P G + Y+++ G + +
Sbjct: 2829 FIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLV 2888
Query: 717 ---IEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
+E + +A YYI Q+LP + RI G
Sbjct: 2889 RRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIG 2924
>sp|O60673|DPOZ_HUMAN DNA POLYMERASE ZETA CATALYTIC SUBUNIT (HREV3)
>gi|3063675|gb|AAC24357.1| (AF058701) DNA polymerase zeta
catalytic subunit [Homo sapiens]
>gi|3243260|gb|AAC24009.1| (AF071798) DNA polymerase zeta
catalytic subunit [Homo sapiens]
>gi|5107941|gb|AAD40184.1|AF157476_1 (AF157476) DNA
polymerase zeta catalytic subunit [Homo sapiens]
Length = 3130
Score = 132 bits (330), Expect = 1e-29
Identities = 145/636 (22%), Positives = 270/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + +I+ DPD+++ Y + YLL+RA L I L + D
Sbjct: 2376 VTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDD 2435
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2436 KIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQ-RFP 2494
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2495 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2552
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2553 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVP--LIMEPESRFYSNSV 2610
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2611 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVS 2670
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++LD RQ +K++AN
Sbjct: 2671 PNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANV 2730
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2731 TFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2790
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV 604
GA E+ + + E + + P ++L++E Y TKK+Y +D++ +
Sbjct: 2791 GATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVF 2850
Query: 605 -TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ ++ + + +
Sbjct: 2851 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLEGKASIQD 2906
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIA 716
I+ + R YK A P + + +++ + +P G + Y+++ G + +
Sbjct: 2907 FIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLV 2966
Query: 717 ---IEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
+E + +A YYI Q+LP + RI G
Sbjct: 2967 RRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIG 3002
>gi|4506483 REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase zeta;
Polymerase, DNA, zeta (Rev-3, yeast, homolog of); Rev-3,
yeast, homolog-like (polymerase, DNA, zeta) [Homo
sapiens] >gi|3378172|gb|AAC28460.1| (AF078695) DNA
polymerase zeta catalytic subunit [Homo sapiens]
Length = 3052
Score = 132 bits (330), Expect = 1e-29
Identities = 145/636 (22%), Positives = 270/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + +I+ DPD+++ Y + YLL+RA L I L + D
Sbjct: 2298 VTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDD 2357
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2358 KIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQ-RFP 2416
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2417 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2474
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2475 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVP--LIMEPESRFYSNSV 2532
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2533 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVS 2592
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++LD RQ +K++AN
Sbjct: 2593 PNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANV 2652
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2653 TFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2712
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV 604
GA E+ + + E + + P ++L++E Y TKK+Y +D++ +
Sbjct: 2713 GATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVF 2772
Query: 605 -TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ ++ + + +
Sbjct: 2773 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLEGKASIQD 2828
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIA 716
I+ + R YK A P + + +++ + +P G + Y+++ G + +
Sbjct: 2829 FIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLV 2888
Query: 717 ---IEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
+E + +A YYI Q+LP + RI G
Sbjct: 2889 RRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIG 2924
>emb|CAB75862.1| (AL080317) dJ1112D6.2 (REV3 (yeast homolog)-like, catalytic subunit
of DNA polymerase zeta (EC 2.7.7.7, POLZ)) [Homo sapiens]
Length = 2909
Score = 132 bits (330), Expect = 1e-29
Identities = 145/636 (22%), Positives = 270/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + +I+ DPD+++ Y + YLL+RA L I L + D
Sbjct: 2155 VTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDD 2214
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2215 KIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQ-RFP 2273
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2274 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2331
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2332 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVP--LIMEPESRFYSNSV 2389
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2390 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVS 2449
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++LD RQ +K++AN
Sbjct: 2450 PNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANV 2509
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2510 TFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2569
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV 604
GA E+ + + E + + P ++L++E Y TKK+Y +D++ +
Sbjct: 2570 GATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVF 2629
Query: 605 -TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ ++ + + +
Sbjct: 2630 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLEGKASIQD 2685
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIA 716
I+ + R YK A P + + +++ + +P G + Y+++ G + +
Sbjct: 2686 FIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLV 2745
Query: 717 ---IEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
+E + +A YYI Q+LP + RI G
Sbjct: 2746 RRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIG 2781
>gb|AAG09402.1|AF179428_1 (AF179428) DNA polymerase zeta catalytic subunit variant 1 [Homo
sapiens] >gi|9957536|gb|AAG09403.1|AF179429_1 (AF179429)
DNA polymerase zeta catalytic subunit variant 2 [Homo
sapiens]
Length = 3052
Score = 132 bits (330), Expect = 1e-29
Identities = 145/636 (22%), Positives = 270/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + +I+ DPD+++ Y + YLL+RA L I L + D
Sbjct: 2298 VTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDD 2357
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2358 KIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQ-RFP 2416
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2417 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2474
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2475 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVP--LIMEPESRFYSNSV 2532
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2533 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVS 2592
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++LD RQ +K++AN
Sbjct: 2593 PNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANV 2652
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2653 TFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2712
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV 604
GA E+ + + E + + P ++L++E Y TKK+Y +D++ +
Sbjct: 2713 GATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVF 2772
Query: 605 -TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ ++ + + +
Sbjct: 2773 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLEGKASIQD 2828
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIA 716
I+ + R YK A P + + +++ + +P G + Y+++ G + +
Sbjct: 2829 FIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLV 2888
Query: 717 ---IEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
+E + +A YYI Q+LP + RI G
Sbjct: 2889 RRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIG 2924
>gi|11417569 REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase zeta
[Homo sapiens]
Length = 2745
Score = 132 bits (330), Expect = 1e-29
Identities = 145/636 (22%), Positives = 270/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + +I+ DPD+++ Y + YLL+RA L I L + D
Sbjct: 1991 VTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDD 2050
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2051 KIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQ-RFP 2109
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2110 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2167
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2168 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVP--LIMEPESRFYSNSV 2225
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2226 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQVRHDITVS 2285
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++LD RQ +K++AN
Sbjct: 2286 PNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANV 2345
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2346 TFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2405
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV 604
GA E+ + + E + + P ++L++E Y TKK+Y +D++ +
Sbjct: 2406 GATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVF 2465
Query: 605 -TRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ ++ + + +
Sbjct: 2466 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLLEGKASIQD 2521
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIA 716
I+ + R YK A P + + +++ + +P G + Y+++ G + +
Sbjct: 2522 FIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPLIQLV 2581
Query: 717 ---IEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
+E + +A YYI Q+LP + RI G
Sbjct: 2582 RRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIG 2617
>sp|P04292|DPOL_HSV1K DNA POLYMERASE >gi|67034|pir||DJBEK1 DNA-directed DNA polymerase
(EC 2.7.7.7) - human herpesvirus 1 (strain KOS)
>gi|330186|gb|AAA66438.1| (M10792) polymerase [human
herpesvirus 1]
Length = 1235
Score = 132 bits (328), Expect = 2e-29
Identities = 152/621 (24%), Positives = 258/621 (41%), Gaps = 109/621 (17%)
Query: 131 GNEELTF--------LAVDIETLYHEGEEFGKGPIIMISYAD----EEGAKVITWKSIDL 178
G +EL F L + I L ++ +++ S E + + +
Sbjct: 375 GEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLPESHLNELAARGLPT 434
Query: 179 PYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPL---GRD 235
P V SE EM+ + ++++ P+ + YN NFD+P+LL + + K+PL GR
Sbjct: 435 PVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDI-YKVPLDGYGRM 493
Query: 236 NSEP--KMQRMGDS-----LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE 288
N ++ +G S +++ G ++ D++ +I I L +Y L AV EA+ K+
Sbjct: 494 NGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKK 553
Query: 289 KVYAHEIAEAWETGKGLERV-AKYSMEDAKVTFELGKEFFP-ME-AQLARLVGQPVWDVS 345
+ +I + TG V +Y ++D+ + +L +F P +E + +ARL G +
Sbjct: 554 DLSYRDIPAYYATGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTI 613
Query: 346 RSSTGNLVEWFLLRKAYERNEL--------------APNKP-----------------DE 374
V LLR A ++ + AP +P DE
Sbjct: 614 YDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDE 673
Query: 375 REYERRLRE------------SYEGGYVKEPEKGLW-EGIVSLDFRSLYPSIIITHNVSP 421
RE RE Y+G V +P G +V DF SLYPSII HN+
Sbjct: 674 REEGGGEREPEGARETAGRHVGYQGAKVLDPTSGFHVNPVVVFDFASLYPSIIQAHNLCF 733
Query: 422 DTL--------NRENCKEYDVAPQVGHR---FCKDF--PGFIPSLLGNLLEERQKIKKRM 468
TL + E K+Y + +VG R F K + LL + L R++I+ R+
Sbjct: 734 STLSLRADAVAHLEAGKDY-LEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRI 792
Query: 469 KESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRE 528
+S P E LLD +Q AIK++ NS YG+ G C A +VT GR+ + R
Sbjct: 793 PQS-SPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREY 851
Query: 529 LESR-----------------------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVE 565
+ +R +++Y DTD ++ G + K
Sbjct: 852 VHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAMGDKMAS 911
Query: 566 YINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQA 624
+I+ L ++LE E + + + KKKY + GK++ +G+++VR++ T
Sbjct: 912 HISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKNNCAFINRTSR 971
Query: 625 KVLEAILKHGNVDEAVKIVKE 645
+++ + V A + E
Sbjct: 972 ALVDLLFYDDTVSGAAAALAE 992
>pir||T17202 DNA-directed DNA polymerase (EC 2.7.7.7) zeta chain - mouse
>gi|4079831|gb|AAC98785.1| (AF083464) DNA polymerase zeta
catalytic subunit [Mus musculus]
Length = 3122
Score = 131 bits (325), Expect = 4e-29
Identities = 144/636 (22%), Positives = 268/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + + +I+ DPD+++ Y + YLL+RA L + L + D
Sbjct: 2368 VTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISRVPDD 2427
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2428 KIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVGLTNYTFENVSFHVLHQ-RFP 2486
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2487 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2544
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2545 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVP--LIMEPESRFYSNSV 2602
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2603 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQIRHDVTVS 2662
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++L+ RQ +K++AN
Sbjct: 2663 PNGVAFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANV 2722
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2723 TFGYTAANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2782
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKY------ALIDEEGKI 603
GA E+ + + E + + P ++L++E Y TKK+Y L +E
Sbjct: 2783 GATKEQSFKIGQEIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVF 2842
Query: 604 VTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ + + + +
Sbjct: 2843 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVHRQCMKLVEGKASIQD 2898
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAI- 715
I+ + R Y+ A P + + +++ A + +P G + Y+++ G + +
Sbjct: 2899 FIFAKEYRGSFSYRPGACVPALELTRKMLAYDRRSEPRVGERVPYVIIYGTPGLPLIQLI 2958
Query: 716 --AIEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
E + +A YYI Q+LP + RI G
Sbjct: 2959 RRPAEVLQDPTLRLNATYYITKQILPPLARIFSLIG 2994
>dbj|BAA90768.1| (AB031049) DNA polymerase [Mus musculus]
Length = 3122
Score = 131 bits (325), Expect = 4e-29
Identities = 144/636 (22%), Positives = 268/636 (41%), Gaps = 76/636 (11%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRD 235
V + E+ + + + +I+ DPD+++ Y + YLL+RA L + L + D
Sbjct: 2368 VTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISRVPDD 2427
Query: 236 NSEPKMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
E + D + I GRI +L+ ++R + L YT E V + + +
Sbjct: 2428 KIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVGLTNYTFENVSFHVLHQ-RFP 2486
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVW 342
++ + W K + ++ M D V+ G + +++ARL G
Sbjct: 2487 LFTFRVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFL 2544
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-I 401
V + VE +LR A N + ++ + R + + EPE + +
Sbjct: 2545 HVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVP--LIMEPESRFYSNSV 2602
Query: 402 VSLDFRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP-- 447
+ LDF+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 2603 LVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQIRHDVTVS 2662
Query: 448 -------------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANS 493
G +P +L +L+ R +K+ MK K D ++L+ RQ +K++AN
Sbjct: 2663 PNGVAFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANV 2722
Query: 494 YYGYYGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIP 549
+GY R C E +S+ R+ ++ + + + G +V+Y DTD ++ +
Sbjct: 2723 TFGYTAANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLK 2782
Query: 550 GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKY------ALIDEEGKI 603
GA E+ + + E + + P ++L++E Y TKK+Y L +E
Sbjct: 2783 GATKEQSFKIGQEIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVF 2842
Query: 604 VTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV-- 661
+G+E VRRD + +K+LE LK + ++K+ + + + +
Sbjct: 2843 DAKGIETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVHRQCMKLVEGKASIQD 2898
Query: 662 -IYEQITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAI- 715
I+ + R Y+ A P + + +++ A + +P G + Y+++ G + +
Sbjct: 2899 FIFAKEYRGSFSYRPGACVPALELTRKMLAYDRRSEPRVGERVPYVIIYGTPGLPLIQLI 2958
Query: 716 --AIEEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
E + +A YYI Q+LP + RI G
Sbjct: 2959 RRPAEVLQDPTLRLNATYYITKQILPPLARIFSLIG 2994
>sp|Q61493|DPOZ_MOUSE DNA POLYMERASE ZETA CATALYTIC SUBUNIT (SEIZURE RELATED PROTEIN 4)
>gi|1304154|dbj|BAA11461.1| (D78644) DNA polymerase [Mus
musculus]
Length = 755
Score = 130 bits (323), Expect = 7e-29
Identities = 143/632 (22%), Positives = 267/632 (41%), Gaps = 76/632 (12%)
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-----PLGRDNSEP 239
+ E+ + + + +I+ DPD+++ Y + YLL+RA L + L + D E
Sbjct: 5 ADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISRVPDDKIEN 64
Query: 240 KMQRMGDSLA------VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAH 293
+ D + I GRI +L+ ++R + L YT E V + + + ++
Sbjct: 65 RFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVGLTNYTFENVSFHVLHQ-RFPLFTF 123
Query: 294 EIAEAWETGKGLERVAKYSMEDAKVTFELGK-------EFFPMEAQLARLVGQPVWDVSR 346
+ W K + ++ M D V+ G + +++ARL G V
Sbjct: 124 RVLSDWFDNK--TDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLT 181
Query: 347 SSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWEG-IVSLD 405
+ VE +LR A N + ++ + R + + EPE + ++ LD
Sbjct: 182 RGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVP--LIMEPESRFYSNSVLVLD 239
Query: 406 FRSLYPSIIITHNVSPDTL--NRENCKEYD----------VAPQVGHRFCKDFP------ 447
F+SLYPSI+I +N T + EN +YD V P + ++ D
Sbjct: 240 FQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQIRHDVTVSPNGV 299
Query: 448 ---------GFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGY 497
G +P +L +L+ R +K+ MK K D ++L+ RQ +K++AN +GY
Sbjct: 300 AFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANVTFGY 359
Query: 498 YGYA-KARWYCKECAESVTAWGRQYIDLVRR---ELESRGFKVLYIDTDGLYATIPGAKH 553
R C E +S+ R+ ++ + + + G +V+Y DTD ++ + GA
Sbjct: 360 TAANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATK 419
Query: 554 EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKY------ALIDEEGKIVTRG 607
E+ + + E + + P ++L++E Y TKK+Y L +E +G
Sbjct: 420 EQSFKIGQEIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVFDAKG 479
Query: 608 LEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLV---IYE 664
+E VRRD + +K+LE LK + ++K+ + + + + I+
Sbjct: 480 IETVRRD----SCPAVSKILERSLKLLFETRDISLIKQYVHRQCMKLVEGKASIQDFIFA 535
Query: 665 QITRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAI---AI 717
+ R Y+ A P + + +++ A + +P G + Y+++ G + +
Sbjct: 536 KEYRGSFSYRPGACVPALELTRKMLAYDRRSEPRVGERVPYVIIYGTPGLPLIQLIRRPA 595
Query: 718 EEFDPKKHKYDAEYYIENQVLPAVERILRAFG 749
E + +A YYI Q+LP + RI G
Sbjct: 596 EVLQDPTLRLNATYYITKQILPPLARIFSLIG 627
>gb|AAG30223.1| (AF298215) DNA polymerase zeta catalytic subunit [Drosophila
melanogaster]
Length = 2130
Score = 129 bits (322), Expect = 9e-29
Identities = 158/635 (24%), Positives = 273/635 (42%), Gaps = 65/635 (10%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-PL------- 232
V+VV+SE E + L+ + D D+ Y + + Y++ RA+ L + PL
Sbjct: 1371 VQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQ 1430
Query: 233 -GRDNSEPKMQRMGDSLAVEIK--GRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
RD + ++ D L VE+K GRI D++ ++R I L +YT E V I K
Sbjct: 1431 KVRDFVDEDREQFTD-LDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPW 1489
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEF--FPMEAQLARLVGQPVWDVSRS 347
A + E + + V +Y +E + T L ++ +++A+L+G ++V
Sbjct: 1490 HTAKSLTEWFGSPCTRWIVMEYYLERVRGTLTLLEQLDLLGRTSEMAKLIGIQFYEVLSR 1549
Query: 348 STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-EGIVSLDF 406
+ VE +LR A +N L P P + Y + EP+ + + ++ LDF
Sbjct: 1550 GSQFRVESMMLRIAKPKN-LVPLSPSVQARAHMRAPEYLA-LIMEPQSRFYADPLIVLDF 1607
Query: 407 RSLYPSIIITHNVSPDT-LNR------------------------ENCKEYDVAP--QVG 439
+SL+PS+II +N T L R + E+D+ G
Sbjct: 1608 QSLHPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCG 1667
Query: 440 HRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVE-KKLLDYRQRAIKILANSYYG 496
F K G +P +L +L+ RQ +K+ MK KD +++L RQ +K++AN YG
Sbjct: 1668 VVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYG 1727
Query: 497 YYGYA-KARWYCKECAESVTAWGRQYIDLVRRELESRG---FKVLYIDTDGLYATIPGAK 552
Y R E +SV + GR+ ++ + +E+ +V+Y DTD ++ +PG
Sbjct: 1728 YTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRN 1787
Query: 553 HEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV-TR 606
E + + + P ++L+ E Y TKK+Y D+E + +
Sbjct: 1788 RAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAK 1847
Query: 607 GLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQI 666
G+E RRD + KVL + + +V + V KL + L+ ++
Sbjct: 1848 GIETERRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEF 1907
Query: 667 TRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFD- 721
R L+ YK A P + + ++ K + P G + +I++ G + + D
Sbjct: 1908 -RGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDI 1966
Query: 722 --PKKHKYDAEYYIENQVLPAVERILRAFGYRKED 754
+ HK +A YYI ++P + R L G D
Sbjct: 1967 LANEGHKINAIYYITKAIIPPLNRCLLLIGANVHD 2001
>gi|9629411 DNA polymerase [human herpesvirus 1]
>gi|118878|sp|P04293|DPOL_HSV11 DNA POLYMERASE
>gi|67038|pir||DJBEH7 DNA-directed DNA polymerase (EC
2.7.7.7) - human herpesvirus 1 (strain 17)
>gi|59530|emb|CAA32323.1| (X14112) DNA polymerase [human
herpesvirus 1] >gi|221751|dbj|BAA01676.1| (D10879)
replicative DNA polymerase [human herpesvirus 1]
Length = 1235
Score = 129 bits (322), Expect = 9e-29
Identities = 151/621 (24%), Positives = 257/621 (41%), Gaps = 109/621 (17%)
Query: 131 GNEELTF--------LAVDIETLYHEGEEFGKGPIIMISYAD----EEGAKVITWKSIDL 178
G +EL F L + I L ++ +++ S E + + +
Sbjct: 375 GEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLPESHLNELAARGLPT 434
Query: 179 PYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPL---GRD 235
P V SE EM+ + ++++ P+ + YN NFD+P+LL + + K+PL GR
Sbjct: 435 PVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDI-YKVPLDGYGRM 493
Query: 236 NSEP--KMQRMGDS-----LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE 288
N ++ +G S +++ G ++ D++ +I I L +Y L AV EA+ K+
Sbjct: 494 NGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKK 553
Query: 289 KVYAHEIAEAWETGKGLERV-AKYSMEDAKVTFELGKEFFP-ME-AQLARLVGQPVWDVS 345
+ +I + G V +Y ++D+ + +L +F P +E + +ARL G +
Sbjct: 554 DLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTI 613
Query: 346 RSSTGNLVEWFLLRKAYERNEL--------------APNKP-----------------DE 374
V LLR A ++ + AP +P DE
Sbjct: 614 YDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDE 673
Query: 375 REYERRLRE------------SYEGGYVKEPEKGLW-EGIVSLDFRSLYPSIIITHNVSP 421
RE RE Y+G V +P G +V DF SLYPSII HN+
Sbjct: 674 REEGGGEREPEGARETAGRHVGYQGARVLDPTSGFHVNPVVVFDFASLYPSIIQAHNLCF 733
Query: 422 DTL--------NRENCKEYDVAPQVGHR---FCKDF--PGFIPSLLGNLLEERQKIKKRM 468
TL + E K+Y + +VG R F K + LL + L R++I+ R+
Sbjct: 734 STLSLRADAVAHLEAGKDY-LEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRI 792
Query: 469 KESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRE 528
+S P E LLD +Q AIK++ NS YG+ G C A +VT GR+ + R
Sbjct: 793 PQS-SPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREY 851
Query: 529 LESR-----------------------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVE 565
+ +R +++Y DTD ++ G + K
Sbjct: 852 VHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAVGDKMAS 911
Query: 566 YINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQA 624
+I+ L ++LE E + + + KKKY + GK++ +G+++VR++ T
Sbjct: 912 HISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKNNCAFINRTSR 971
Query: 625 KVLEAILKHGNVDEAVKIVKE 645
+++ + V A + E
Sbjct: 972 ALVDLLFYDDTVSGAAAALAE 992
>pir||DJBEV1 DNA-directed DNA polymerase (EC 2.7.7.7) - human herpesvirus 1
>gi|59864|emb|CAA26941.1| (X03181) DNA polymerase [human
herpesvirus 1]
Length = 1235
Score = 129 bits (322), Expect = 9e-29
Identities = 151/621 (24%), Positives = 257/621 (41%), Gaps = 109/621 (17%)
Query: 131 GNEELTF--------LAVDIETLYHEGEEFGKGPIIMISYAD----EEGAKVITWKSIDL 178
G +EL F L + I L ++ +++ S E + + +
Sbjct: 375 GEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLPESHLNELAARGLPT 434
Query: 179 PYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPL---GRD 235
P V SE EM+ + ++++ P+ + YN NFD+P+LL + + K+PL GR
Sbjct: 435 PVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDI-YKVPLDGYGRM 493
Query: 236 NSEP--KMQRMGDS-----LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE 288
N ++ +G S +++ G ++ D++ +I I L +Y L AV EA+ K+
Sbjct: 494 NGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKK 553
Query: 289 KVYAHEIAEAWETGKGLERV-AKYSMEDAKVTFELGKEFFP-ME-AQLARLVGQPVWDVS 345
+ +I + G V +Y ++D+ + +L +F P +E + +ARL G +
Sbjct: 554 DLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTI 613
Query: 346 RSSTGNLVEWFLLRKAYERNEL--------------APNKP-----------------DE 374
V LLR A ++ + AP +P DE
Sbjct: 614 YDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDE 673
Query: 375 REYERRLRE------------SYEGGYVKEPEKGLW-EGIVSLDFRSLYPSIIITHNVSP 421
RE RE Y+G V +P G +V DF SLYPSII HN+
Sbjct: 674 REEGGGEREPEGARETAGRHVGYQGARVLDPTSGFHVNPVVVFDFASLYPSIIQAHNLCF 733
Query: 422 DTL--------NRENCKEYDVAPQVGHR---FCKDF--PGFIPSLLGNLLEERQKIKKRM 468
TL + E K+Y + +VG R F K + LL + L R++I+ R+
Sbjct: 734 STLSLRADAVAHLEAGKDY-LEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRI 792
Query: 469 KESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRE 528
+S P E LLD +Q AIK++ NS YG+ G C A +VT GR+ + R
Sbjct: 793 PQS-SPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREY 851
Query: 529 LESR-----------------------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVE 565
+ +R +++Y DTD ++ G + K
Sbjct: 852 VHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAVGDKMAS 911
Query: 566 YINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQA 624
+I+ L ++LE E + + + KKKY + GK++ +G+++VR++ T
Sbjct: 912 HISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKNNCAFINRTSR 971
Query: 625 KVLEAILKHGNVDEAVKIVKE 645
+++ + V A + E
Sbjct: 972 ALVDLLFYDDTVSGAAAALAE 992
>sp|P09854|DPOL_HSV1S DNA POLYMERASE >gi|67035|pir||DJBE16 DNA-directed DNA polymerase
(EC 2.7.7.7) - human herpesvirus 1 (strain SC16)
>gi|59840|emb|CAA28464.1| (X04771) DNA polymerase (AA
1-1235) [human herpesvirus 1]
Length = 1235
Score = 129 bits (321), Expect = 1e-28
Identities = 151/621 (24%), Positives = 256/621 (40%), Gaps = 109/621 (17%)
Query: 131 GNEELTF--------LAVDIETLYHEGEEFGKGPIIMISYAD----EEGAKVITWKSIDL 178
G +EL F L + I L ++ +++ S E + + +
Sbjct: 375 GEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLPESHLNELAARGLPT 434
Query: 179 PYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPL---GRD 235
P V SE EM+ + ++++ P+ + YN NFD+P+LL + + K+PL GR
Sbjct: 435 PVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDI-YKVPLDGYGRM 493
Query: 236 NSEP--KMQRMGDS-----LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE 288
N ++ +G S +++ G + D++ +I I L +Y L AV EA+ K+
Sbjct: 494 NGRGVFRVWDIGQSHFQKRSKIKVNGMVSIDMYGIITDKIKLSSYKLNAVAEAVLKDKKK 553
Query: 289 KVYAHEIAEAWETGKGLERV-AKYSMEDAKVTFELGKEFFP-ME-AQLARLVGQPVWDVS 345
+ +I + G V +Y ++D+ + +L +F P +E + +ARL G +
Sbjct: 554 DLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTI 613
Query: 346 RSSTGNLVEWFLLRKAYERNEL--------------APNKP-----------------DE 374
V LLR A ++ + AP +P DE
Sbjct: 614 YDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDE 673
Query: 375 REYERRLRE------------SYEGGYVKEPEKGLW-EGIVSLDFRSLYPSIIITHNVSP 421
RE RE Y+G V +P G +V DF SLYPSII HN+
Sbjct: 674 REEGGGEREPDGARETAGRHVGYQGARVLDPTSGFHVNPVVVFDFASLYPSIIQAHNLCF 733
Query: 422 DTL--------NRENCKEYDVAPQVGHR---FCKDF--PGFIPSLLGNLLEERQKIKKRM 468
TL + E K+Y + +VG R F K + LL + L R++I+ R+
Sbjct: 734 STLSLRADAVAHLEAGKDY-LEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRI 792
Query: 469 KESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRE 528
+S P E LLD +Q AIK++ NS YG+ G C A +VT GR+ + R
Sbjct: 793 PQS-SPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREY 851
Query: 529 LESR-----------------------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVE 565
+ +R +++Y DTD ++ G + K
Sbjct: 852 VHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAMGDKMAS 911
Query: 566 YINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQA 624
+I+ L ++LE E + + + KKKY + GK++ +G+++VR++ T
Sbjct: 912 HISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKNNCAFINRTSR 971
Query: 625 KVLEAILKHGNVDEAVKIVKE 645
+++ + V A + E
Sbjct: 972 ALVDLLFYDDTVSGAAAALAE 992
>sp|P07917|DPOL_HSV1A DNA POLYMERASE >gi|67036|pir||DJBEAN DNA-directed DNA polymerase
(EC 2.7.7.7) - human herpesvirus 1 (strain Angelotti)
>gi|59861|emb|CAA28183.1| (X04495) DNA polymerase (AA
1-1235) [human herpesvirus 1]
Length = 1235
Score = 129 bits (321), Expect = 1e-28
Identities = 151/621 (24%), Positives = 257/621 (41%), Gaps = 109/621 (17%)
Query: 131 GNEELTF--------LAVDIETLYHEGEEFGKGPIIMISYAD----EEGAKVITWKSIDL 178
G +EL F L + I L ++ +++ S E + + +
Sbjct: 375 GEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLPESHLTELAARGLPT 434
Query: 179 PYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPL---GRD 235
P V SE EM+ + ++++ P+ + YN NFD+P+LL + + K+PL GR
Sbjct: 435 PVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDI-YKVPLDGYGRM 493
Query: 236 NSEP--KMQRMGDS-----LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKE 288
N ++ +G S +++ G ++ D++ +I I L +Y L AV EA+ K+
Sbjct: 494 NGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKK 553
Query: 289 KVYAHEIAEAWETGKGLERV-AKYSMEDAKVTFELGKEFFP-ME-AQLARLVGQPVWDVS 345
+ +I + G V +Y ++D+ + +L +F P +E + +ARL G +
Sbjct: 554 DLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTI 613
Query: 346 RSSTGNLVEWFLLRKAYERNEL--------------APNKP-----------------DE 374
V LLR A ++ + AP +P DE
Sbjct: 614 YDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDE 673
Query: 375 REYERRLRE------------SYEGGYVKEPEKGLW-EGIVSLDFRSLYPSIIITHNVSP 421
RE RE Y+G V +P G +V DF SLYPSII HN+
Sbjct: 674 REEGGGEREPEGARETAGRHVGYQGARVLDPTSGFHVNPVVVFDFASLYPSIIQAHNLCF 733
Query: 422 DTL--------NRENCKEYDVAPQVGHR---FCKDF--PGFIPSLLGNLLEERQKIKKRM 468
TL + E K+Y + +VG R F K + LL + L R++I+ R+
Sbjct: 734 STLSLRADAVAHLEAGKDY-LEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRI 792
Query: 469 KESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRE 528
+S P E LLD +Q AIK++ NS YG+ G C A +VT GR+ + R
Sbjct: 793 PQS-SPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREY 851
Query: 529 LESR-----------------------GFKVLYIDTDGLYATIPGAKHEEIKEKALKFVE 565
+ +R +++Y DTD ++ G + K
Sbjct: 852 VHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLTAVGDKMAS 911
Query: 566 YINSKL-PGLLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQA 624
+I+ L ++LE E + + + KKKY + GK++ +G+++VR++ T
Sbjct: 912 HISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRKNNCAFINRTSR 971
Query: 625 KVLEAILKHGNVDEAVKIVKE 645
+++ + V A + E
Sbjct: 972 ALVDLLFYDDTVSGAAAALAE 992
>gb|AAA74383.1| (L24487) DNA polymerase [Pseudorabies virus]
Length = 1048
Score = 128 bits (319), Expect = 2e-28
Identities = 142/497 (28%), Positives = 228/497 (45%), Gaps = 75/497 (15%)
Query: 177 DLPYVEVVS--SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYL-LKRAEKLGIKLP-L 232
D P V V+ SE E++ V +++ P+ YN NFD+ ++ K G+ L
Sbjct: 331 DDPAVTVLEFDSEFELLLAFVTFLKQYAPEFATGYNIINFDWAFVHTKLTTVYGLALDGY 390
Query: 233 GRDNSEPKMQRMGDS--------LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFG 284
GR N + R+ D+ V+I G + D++ V + LP+Y L AV E G
Sbjct: 391 GRFNRGGQF-RVYDAGQNSFQKRSKVKINGLVSLDMYAVAADKLKLPSYKLNAVAEEALG 449
Query: 285 KSKEKVYAHEIAEAWETGKGLER--VAKYSMEDAKVTFELGKEFFP-----MEAQLARL- 336
+ K + +I + G ER + +Y ++D+ + +L +F P A+LA +
Sbjct: 450 ERKLDLDYKDIPRYYAAGPR-ERGVIGRYCVQDSALVGKLFFKFLPHLELSAVARLANIT 508
Query: 337 VGQPVWDVSRSSTGNLVEWF--LLRKAYERNELAPNK----PDEREYERRLRESYEGGYV 390
+ + ++D G + F LL+ A R + P+K DE + Y+G V
Sbjct: 509 LARAIYD------GQQIRVFTCLLKLAGSRGFVLPDKRRAIADEDD-----GGGYQGAKV 557
Query: 391 KEPEKGLW-EGIVSLDFRSLYPSIIITHNVSPDTLN-------RENCKEYDVAPQVGHRF 442
EP+ G + ++ LDF SLYPSII HN+ TL RE+ E+ G R
Sbjct: 558 LEPDSGFHVDPVLVLDFASLYPSIIQAHNLCFTTLALARPAGLRED--EFSAFEVNGERL 615
Query: 443 CKDFPGFIPSLLGNLLEE----RQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYY 498
G SLL LL + R+ I+ R+ S P E LLD +Q AIK++ NS YG+
Sbjct: 616 YFVHAGVRESLLSILLRDWLAMRKAIRARIPTSA-PEEAVLLDKQQAAIKVVCNSVYGFT 674
Query: 499 GYAKARWYCKECAESVTAWGRQYI--------------DLVRRELESR------GFKVLY 538
G A C A +VT GR + +L+ R+L +R +V+Y
Sbjct: 675 GVANGLLPCLPVAATVTTIGRDMLVATRDYVQTRWATRELLERDLPARPPAGEYAVRVVY 734
Query: 539 IDTDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFVTKKKYALI 597
DTD ++ G ++++ E I L ++LE E + R +TKKKY +
Sbjct: 735 GDTDSVFIRFSGIAYDDVCELGELMAARITRDLFRPPIKLECEKTFRRLLLITKKKYIGV 794
Query: 598 DEEGKIVTRGLEIVRRD 614
GK++ +G+++VR++
Sbjct: 795 INGGKMLMKGVDLVRKN 811
>gi|9625903 ORF28 (AA1-1194) [Human herpesvirus 3] >gi|118893|sp|P09252|DPOL_VZVD
DNA POLYMERASE >gi|67040|pir||DJBE28 DNA-directed DNA
polymerase (EC 2.7.7.7) - human herpesvirus 3
>gi|60017|emb|CAA27911.1| (X04370) ORF28 (AA1-1194)
[Human herpesvirus 3]
Length = 1194
Score = 127 bits (317), Expect = 4e-28
Identities = 144/596 (24%), Positives = 260/596 (43%), Gaps = 103/596 (17%)
Query: 179 PYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKL-GIKLP-LGRDN 236
P V SE E++ + ++++ P+ YN NFD+ +++++ + +KL G N
Sbjct: 416 PTVLEFDSEFELLIAFMTLVKQYAPEFATGYNIVNFDWAFIMEKLNSIYSLKLDGYGSIN 475
Query: 237 SEP--KMQRMGDS-----LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
K+ +G S V+I G I D++ + + L +Y L++V +SK
Sbjct: 476 RGGLFKIWDVGKSGFQRRSKVKINGLISLDMYAIATEKLKLSSYKLDSVAREALNESKRD 535
Query: 290 VYAHEIAEAWETGKGLERV-AKYSMEDAKVTFELGKEFFP-----MEAQLARL-VGQPVW 342
+ +I + +G + +Y ++D+ + +L ++ P A+LAR+ + + ++
Sbjct: 536 LPYKDIPGYYASGPNTRGIIGEYCIQDSALVGKLFFKYLPHLELSAVARLARITLTKAIY 595
Query: 343 DVSR-----------SSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRES------- 384
D + SS G ++ +E ++ P+ D E E ES
Sbjct: 596 DGQQVRIYTCLLGLASSRGFILPDGGYPATFEYKDVIPDVGDVEE-EMDEDESVSPTGTS 654
Query: 385 ------YEGGYVKEPEKGLW-EGIVSLDFRSLYPSIIITHNV-------SPDTLNRENCK 430
Y+G V +P+ G + + +V LDF SLYPSII HN+ + +T+ R N
Sbjct: 655 SGRNVGYKGARVFDPDTGFYIDPVVVLDFASLYPSIIQAHNLCFTTLTLNFETVKRLNPS 714
Query: 431 EYDVAPQVGHRFCKDFPGFIPSLLGNLLEE----RQKIKKRMKESKDPVEKKLLDYRQRA 486
+Y G R SLLG LL++ R+ I+ R+ S E LLD +Q A
Sbjct: 715 DYATFTVGGKRLFFVRSNVRESLLGVLLKDWLAMRKAIRARIPGSSSD-EAVLLDKQQAA 773
Query: 487 IKILANSYYGYYGYAKARWYCKECAESVTAWGRQYI----------------------DL 524
IK++ NS YG+ G A+ C A +VT GRQ + D+
Sbjct: 774 IKVVCNSVYGFTGVAQGFLPCLYVAATVTTIGRQMLLSTRDYIHNNWAAFERFITAFPDI 833
Query: 525 VRRELESRGF--KVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEG 581
L + + KV+Y DTD ++ G E I + K I++ L ++LE E
Sbjct: 834 ESSVLSQKAYEVKVIYGDTDSVFIRFKGVSVEGIAKIGEKMAHIISTALFCPPIKLECEK 893
Query: 582 FYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAV- 640
+ + +TKKKY + GK++ +G+++VR++ + + K++E +L V A
Sbjct: 894 TFIKLLLITKKKYIGVIYGGKVLMKGVDLVRKNNCQFINDYARKLVELLLYDDTVSRAAA 953
Query: 641 -----------------------KIVKEVTEKLSKYEIPPEKLVIYEQITRPLSEY 673
+I+ + +++ ++ K V+ +++RP S Y
Sbjct: 954 EASCVSIAEWNRRAMPSGMAGFGRIIADAHRQITSPKLDINKFVMTAELSRPPSAY 1009
>gb|AAF59191.1| (AE003839) CG1925 gene product [Drosophila melanogaster]
Length = 1869
Score = 113 bits (281), Expect = 6e-24
Identities = 155/635 (24%), Positives = 265/635 (41%), Gaps = 91/635 (14%)
Query: 181 VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL-PL------- 232
V+VV+SE E + L+ + D D+ Y + + Y++ RA+ L + PL
Sbjct: 1136 VQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQ 1195
Query: 233 -GRDNSEPKMQRMGDSLAVEIK--GRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEK 289
RD + ++ D L VE+K GRI D P +T +++ E FG +
Sbjct: 1196 KVRDFVDEDREQFTD-LDVEMKLCGRILLD---------RCPWHTAKSLTEW-FGSPCTR 1244
Query: 290 VYAHEIAEAWETGKGLERVAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPVWDVSRS 347
W V +Y +E + T L + +++A+L+G ++V
Sbjct: 1245 ---------WI-------VMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSR 1288
Query: 348 STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW-EGIVSLDF 406
+ VE +LR A +N L P P + Y + EP+ + + ++ LDF
Sbjct: 1289 GSQFRVESMMLRIAKPKN-LVPLSPSVQARAHMRAPEYLA-LIMEPQSRFYADPLIVLDF 1346
Query: 407 RSLYPSIIITHNVSPDT-LNR------------------------ENCKEYDVAP--QVG 439
+SLYPS+II +N T L R + E+D+ G
Sbjct: 1347 QSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCG 1406
Query: 440 HRFCKDF--PGFIPSLLGNLLEERQKIKKRMKESKDPVE-KKLLDYRQRAIKILANSYYG 496
F K G +P +L +L+ RQ +K+ MK KD +++L RQ +K++AN YG
Sbjct: 1407 VVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYG 1466
Query: 497 YYGYA-KARWYCKECAESVTAWGRQYIDLVRRELESRG---FKVLYIDTDGLYATIPGAK 552
Y R E +SV + GR+ ++ + +E+ +V+Y DTD ++ +PG
Sbjct: 1467 YTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRN 1526
Query: 553 HEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA-----LIDEEGKIV-TR 606
E + + + P ++L+ E Y TKK+Y D+E + +
Sbjct: 1527 RAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAK 1586
Query: 607 GLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQI 666
G+E VRRD + KVL + + +V + V KL + L+ ++
Sbjct: 1587 GIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEF 1646
Query: 667 TRPLSEYK--AIGPHVAVAKRLAAKGVKVKP--GMVIGYIVLRGDGPISKRAIAIEEFD- 721
R L+ YK A P + + ++ K + P G + +I++ G + + D
Sbjct: 1647 -RGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDI 1705
Query: 722 --PKKHKYDAEYYIENQVLPAVERILRAFGYRKED 754
+ HK +A YYI ++P + R L G D
Sbjct: 1706 LANEGHKINAIYYITKAIIPPLNRCLLLIGANVHD 1740
>gb|AAC77870.1| (AC005623) putative DNA polymerase epsilon catalytic subunit
[Arabidopsis thaliana]
Length = 2154
Score = 108 bits (266), Expect = 3e-22
Identities = 128/499 (25%), Positives = 212/499 (41%), Gaps = 110/499 (22%)
Query: 3 IDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHGKI 62
+D ++T+DG FK +Y FRPY+YA KD+ ++ + ++
Sbjct: 60 VDLFFVTQDGS-----------SFKTKYK--FRPYLYAATKDNMELEVEAYLRRRYERQV 106
Query: 63 VRITEVEK-----------VQKKFLGRPIEVWKLYLEHPQDVPAIRE------------- 98
I V K +QKK+L + + +E +D+ I E
Sbjct: 107 ADIQIVHKEDLYLKNHLSGLQKKYLKVSFDTVQQLVEVKRDLLHIVERNLAKFNALEAYE 166
Query: 99 -----KIREHP-----AVVDIFEYDIPFAKRYLIDKGL--------------------TP 128
K + P +VVD+ EYD+P+ R+ ID + T
Sbjct: 167 SILSGKREQRPQDCLDSVVDLREYDVPYHVRFAIDNDVRSGQWYNVSISSTDVILEKRTD 226
Query: 129 MEGNEELTFLAVDIET----LYHEGEEFGKGPIIMISY-ADEEGAKVITWKSI-----DL 178
+ E+ A DIET L E+ + I+MISY D +G + + + DL
Sbjct: 227 LLQRAEVRVCAFDIETVKLPLKFPDAEYDQ--IMMISYMVDGQGFLITNRECVGKDIEDL 284
Query: 179 PY-----------VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG 227
Y V V++E E++++ ++E P + +TYNGD FD+P++ +RA G
Sbjct: 285 EYTPKPEFEGYFKVTNVTNEVELLRKWFSHMQELKPGIYVTYNGDFFDWPFIERRASHHG 344
Query: 228 IKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGK 285
IK+ N E + + K H D F ++R LP + L+AV + G
Sbjct: 345 IKM-----NEELGFRCDQNQGECRAKFVCHLDCFSWVKRDSYLPQGSQGLKAVTKVKLGY 399
Query: 286 SKEKVYAHEIAE-AWETGKGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWD 343
+V ++ A E + +A YS+ DA T+ L + P LA ++ +
Sbjct: 400 DPLEVNPEDMVRFAMEKP---QTMASYSVSDAVATYYLYMTYVHPFVFSLATIIPMVPDE 456
Query: 344 VSRSSTGNLVEWFLLRKAYERNELAPNK---PDEREYERRLRES--YEGGYVKEPEKGLW 398
V R +G L E L+ +AY+ N + PNK E+ Y+ +L ES Y GG+V+ + G++
Sbjct: 457 VLRKGSGTLCEMLLMVEAYKANVVCPNKNQADPEKFYQGKLLESETYIGGHVECLQSGVF 516
Query: 399 EGIVSLDFR---SLYPSII 414
+ F+ S Y +I
Sbjct: 517 RSDIPTSFKLDASAYQQLI 535
>gb|AAF18240.1|AC011438_2 (AC011438) T23G18.11 [Arabidopsis thaliana]
Length = 2271
Score = 99.5 bits (244), Expect = 1e-19
Identities = 128/490 (26%), Positives = 203/490 (41%), Gaps = 119/490 (24%)
Query: 3 IDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAIDEVKKITAERHGKI 62
+D ++T+DG FK +Y FRPY YA KD ++ + ++
Sbjct: 68 VDLYFVTQDGF-----------SFKTKYK--FRPYFYAATKDKMELELEAYLRRRYERQV 114
Query: 63 VRITEVEK-----------VQKKFLGRPIEVWKLYLEHPQDVPAIRE------------- 98
I VEK +QKK+L + + +E +D+ I E
Sbjct: 115 ADIEIVEKEDLDLKNHLSGLQKKYLKISFDTVQQLMEVKRDLLHIVERNQAKFDALEAYE 174
Query: 99 -----KIREHP-----AVVDIFEYDIPFAKRYLIDKGL--------------------TP 128
K + P ++VD+ EYD+P+ R+ ID + T
Sbjct: 175 SILAGKREQRPQDCLDSIVDLREYDVPYHVRFAIDNDVRSGQWYNVSISSTDVILEKRTD 234
Query: 129 MEGNEELTFLAVDIET----LYHEGEEFGKGPIIMISY-ADEEGAKVITWKSI------- 176
+ E+ A DIET L E+ + I+MISY D +G +I +
Sbjct: 235 LLQRAEVRVCAFDIETTKLPLKFPDAEYDQ--IMMISYMVDGQGFLIINREVTACVGEDV 292
Query: 177 -DLPY-----------VEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAE 224
DL Y V V +E E+++R ++E P + +TYNGD FD+P++ +RA
Sbjct: 293 EDLEYTPKPEFEGYFKVTNVKNEVELLQRWFYHMQELKPGIYVTYNGDFFDWPFIERRAS 352
Query: 225 KLGIKLPLGRDNSEPKMQRMGDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAI 282
GIK+ N E + + K H D F ++R LP ++ L+AV +A
Sbjct: 353 HHGIKM-----NEELGFRCDQNQGECRAKFACHLDCFAWVKRDSYLPQGSHGLKAVTKAK 407
Query: 283 FGKSKEKVYAHEIAE-AWETGKGLERVAKYSMEDAKVTFELGKEFF-PMEAQLARLVGQP 340
G +V ++ A E + +A YS+ DA T+ L + P LA ++
Sbjct: 408 LGYDPLEVNPEDMVRFAMEKP---QTMASYSVSDAVATYYLYMTYVNPFIFSLATIIPMV 464
Query: 341 VWDVSRSSTGNLVEWFLL---------RKAYERNELAPNK---PDEREYERRLRES--YE 386
+V R +G L E L+ +AY+ N + PNK E+ Y+ +L ES Y
Sbjct: 465 PDEVLRKGSGTLCEMLLMVEVSTYLPQAQAYKANVVCPNKNQADPEKFYQNQLLESETYI 524
Query: 387 GGYVKEPEKG 396
GG+V+ E G
Sbjct: 525 GGHVECLESG 534
>sp|Q85428|DPOL_RCMVM DNA POLYMERASE
Length = 1120
Score = 99.1 bits (243), Expect = 2e-19
Identities = 108/429 (25%), Positives = 185/429 (42%), Gaps = 70/429 (16%)
Query: 385 YEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTL--------NRENCKEYDVA 435
Y+G V PE G I+ DF SLYPSII+++N+ TL E+ E V
Sbjct: 629 YQGATVLAPECGYHHNPILVFDFASLYPSIIMSNNLCYSTLLVDGSPPVPDEDVLEVVVG 688
Query: 436 PQVGHRFCKDFP--GFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANS 493
+RF ++ + LL L++R+ ++ MK D ++ +D +Q A+K+ N+
Sbjct: 689 EATRYRFVREHVRRSLLAELLVRWLKQRKLVRDAMKACGDEKQRMFMDKQQLALKVTCNA 748
Query: 494 YYGYYGYAKARWYCKECAESVTAWGRQ-------YIDL-------------VRRELESRG 533
+YG+ G A C A S+T GR Y++ V RE R
Sbjct: 749 FYGFTGVAAPMLPCLPIAASITKIGRDMLLATSAYMERHCNDVEFLVSEVGVPREAVDRD 808
Query: 534 ---FKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFV 589
K++Y DTD ++ G E + + A K + L + LE+E + +
Sbjct: 809 ALRVKIVYGDTDSVFVGFRGIGREVLVKVAGKLAAAVTRDLFRDPVRLEFEKMFVSLMMI 868
Query: 590 TKKKY-ALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVT- 647
KK+Y + E K+ +G+++VRR + ++V++ I V E + E++
Sbjct: 869 CKKRYIGKVYGENKLCMKGVDLVRRHACAFVRSIVSEVVDVIFHDEAVSEGAMRLSEMSF 928
Query: 648 EKLSKY-----------------------EIPPEKLVIYEQITRPLSEYKAIG-PHVAVA 683
E+L + +P +LV+ +++ S YK PH+AV
Sbjct: 929 EELRRQGVPVGFFPVIRRLCDARDDLFLDRVPVAQLVLSSVLSQDASRYKQKNLPHLAVY 988
Query: 684 KRLAAKGVKVKPGM--VIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIE-----NQ 736
+ L +G ++ PG+ I Y++ D KRA E + H +A+ I +Q
Sbjct: 989 RSLVERGEEL-PGVGDRIEYVLTCPD-ESKKRAPNYEVAEDPAHVREAKIPIHAEKYFDQ 1046
Query: 737 VLPAVERIL 745
++ AV +L
Sbjct: 1047 IVKAVTNVL 1055
>gi|9845346 pR54 [rat cytomegalovirus Maastricht]
>gi|9800279|gb|AAF99153.1|AF232689_46 (AF232689) pR54
[rat cytomegalovirus Maastricht]
Length = 1173
Score = 99.1 bits (243), Expect = 2e-19
Identities = 108/429 (25%), Positives = 185/429 (42%), Gaps = 70/429 (16%)
Query: 385 YEGGYVKEPEKGLWEG-IVSLDFRSLYPSIIITHNVSPDTL--------NRENCKEYDVA 435
Y+G V PE G I+ DF SLYPSII+++N+ TL E+ E V
Sbjct: 629 YQGATVLAPECGYHHNPILVFDFASLYPSIIMSNNLCYSTLLVDGSPPVPDEDVLEVVVG 688
Query: 436 PQVGHRFCKDFP--GFIPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANS 493
+RF ++ + LL L++R+ ++ MK D ++ +D +Q A+K+ N+
Sbjct: 689 EATRYRFVREHVRRSLLAELLVRWLKQRKLVRDAMKACGDEKQRMFMDKQQLALKVTCNA 748
Query: 494 YYGYYGYAKARWYCKECAESVTAWGRQ-------YIDL-------------VRRELESRG 533
+YG+ G A C A S+T GR Y++ V RE R
Sbjct: 749 FYGFTGVAAPMLPCLPIAASITKIGRDMLLATSAYMERHCNDVEFLVSEVGVPREAVDRD 808
Query: 534 ---FKVLYIDTDGLYATIPGAKHEEIKEKALKFVEYINSKL-PGLLELEYEGFYARGFFV 589
K++Y DTD ++ G E + + A K + L + LE+E + +
Sbjct: 809 ALRVKIVYGDTDSVFVGFRGIGREVLVKVAGKLAAAVTRDLFRDPVRLEFEKMFVSLMMI 868
Query: 590 TKKKY-ALIDEEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVT- 647
KK+Y + E K+ +G+++VRR + ++V++ I V E + E++
Sbjct: 869 CKKRYIGKVYGENKLCMKGVDLVRRHACAFVRSIVSEVVDVIFHDEAVSEGAMRLSEMSF 928
Query: 648 EKLSKY-----------------------EIPPEKLVIYEQITRPLSEYKAIG-PHVAVA 683
E+L + +P +LV+ +++ S YK PH+AV
Sbjct: 929 EELRRQGVPVGFFPVIRRLCDARDDLFLDRVPVAQLVLSSVLSQDASRYKQKNLPHLAVY 988
Query: 684 KRLAAKGVKVKPGM--VIGYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIE-----NQ 736
+ L +G ++ PG+ I Y++ D KRA E + H +A+ I +Q
Sbjct: 989 RSLVERGEEL-PGVGDRIEYVLTCPD-ESKKRAPNYEVAEDPAHVREAKIPIHAEKYFDQ 1046
Query: 737 VLPAVERIL 745
++ AV +L
Sbjct: 1047 IVKAVTNVL 1055
>gb|AAD01637.1| (AF019254) DNA polymerase epsilon homolog [Aspergillus nidulans]
Length = 2207
Score = 97.5 bits (239), Expect = 5e-19
Identities = 111/353 (31%), Positives = 161/353 (45%), Gaps = 65/353 (18%)
Query: 106 VVDIFEYDIPFAKRYLIDK-----------------GLTPMEGNEELT-----FLAVDIE 143
++DI EYD+P+ R IDK LT +E E LT LA DIE
Sbjct: 204 IIDIREYDVPYHVRVAIDKDIRIGKWYTVEATHGIISLTCLE--ERLTRADPVVLAFDIE 261
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSI------DLPYVEVVS---------- 185
T L + + I+MISY + +IT + I D Y
Sbjct: 262 TTKLPLKFPDSVIDQIMMISYMIDGQGFLITNREIVSEDIDDFEYTPKPEYSGPFMIFNE 321
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKL--PLG-RDNSEPKM 241
+ER +I+R + I+E P VI TYNGD FD+P++ RA LGI + +G R NSE
Sbjct: 322 PNERAVIERFFEHIKEAKPTVIATYNGDFFDWPFVEARASVLGIDMYKEIGFRKNSEDIY 381
Query: 242 QRMGDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAW 299
Q D A H D F + R LP + L+AV A G +++ E+ +
Sbjct: 382 Q--SDHCA-------HMDCFAWVNRDSYLPQGSRGLKAVTVAKLGYDPDEL-DPELMTPY 431
Query: 300 ETGKGLERVAKYSMEDAKVTFELGKEFF-PMEAQLARLVGQPVWDVSRSSTGNLVEWFLL 358
+ + + +A+YS+ DA T+ L ++ P L ++ D R TG L E L+
Sbjct: 432 ASERP-QTLAEYSVSDAVATYYLYMKYIHPFIFSLCTILPLNPDDTLRKGTGTLCEMLLM 490
Query: 359 RKAYERNELAPNK---PDEREYERRLRES--YEGGYVKEPEKGLWEGIVSLDF 406
+AY+ N + PNK P E YE L ES Y GG+V+ E G++ + + F
Sbjct: 491 VQAYKGNIVLPNKHKDPPEAFYEGHLLESETYVGGHVESIEAGVFRSDIPVPF 543
>gb|AAA23684.1| (M37727) DNA polymerase II [Escherichia coli]
Length = 458
Score = 96.3 bits (236), Expect = 1e-18
Identities = 102/382 (26%), Positives = 176/382 (45%), Gaps = 66/382 (17%)
Query: 82 VWKLYLEHPQDVPAIREKIREHPAVVDIFEYDIPFAKRYLIDKGLTP---MEGNEE---- 134
V+ LY + + +++RE V ++E D+ +RYL+++ +T +EG+
Sbjct: 78 VYGLYCRAHRQLMNYEKRLRE--GGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTI 135
Query: 135 --------------LTFLAVDIETLYHEGEEF-----GKGPIIMISYADEEGAKVITWKS 175
L ++++DIET H GE + G G I+ E G S
Sbjct: 136 VNARLKPHPDYRPPLKWVSIDIETTRH-GELYCIGLEGCGQRIVYMLGPENGDA----SS 190
Query: 176 IDLPYVEVVSSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRD 235
+D +E V+S +++++L DPDVII +N FD L K AE+ + L LGRD
Sbjct: 191 LDFE-LEYVASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGRD 249
Query: 236 NSEPKMQRMGDSLAV---EIKGRIHFDLFPVIRRTI-NLPTYTLEAVYEAIFGKSKEKVY 291
NSE + + G V + KG + D ++ N +++LE V + + G+ K
Sbjct: 250 NSELEWRDDGFKNGVFFAQAKGGLIIDGIEALKSAFWNFSSFSLETVAQELLGEGK---- 305
Query: 292 AHEIAEAWETGKGLER--------VAKYSMEDAKVTFEL--GKEFFPMEAQLARLVGQPV 341
I W+ ++R +A Y+++D ++ ++ E P + A + G PV
Sbjct: 306 --SIDNPWDRMDEIDRRFAEDKPALATYNLKDCELVTQIFHKTEIMPFLLERATVNGLPV 363
Query: 342 --WDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLWE 399
S ++ G+L + R Y +APN + + + GGYV + GL++
Sbjct: 364 DRHGGSVAAFGHLYFPRMHRAGY----VAPNLGEVPPH------ASPGGYVMDSRPGLYD 413
Query: 400 GIVSLDFRSLYPSIIITHNVSP 421
++ LD++SLYPSII T + P
Sbjct: 414 SVLVLDYKSLYPSIIRTFLIDP 435
>emb|CAB58420.1| (AL122012) probable DNA polymerase zeta catalytic component
[Leishmania major]
Length = 3096
Score = 94.8 bits (232), Expect = 3e-18
Identities = 131/575 (22%), Positives = 232/575 (39%), Gaps = 84/575 (14%)
Query: 250 VEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKS---------KEKVYAHEIAEAWE 300
+ + GRI L +R+ I +P+Y+L V+ + G+ E + A+A
Sbjct: 2132 MHVVGRICTSLGRDLRKEIKMPSYSLSMVHVQLLGQPLPYFTDSYLSELFLTPQCADALG 2191
Query: 301 TGK---GLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFL 357
G+ L +A ++ +L +F + +R+ G +V + VE L
Sbjct: 2192 GGERHTALRYLASRVAAPHRIACKL--RWFTRLLEFSRMYGILTKEVITRGSQFRVEATL 2249
Query: 358 LRKAYERNELAPNKPDEREYERRLRESYEGGYVKEPEKGLW--EGIVSLDFRSLYPSIII 415
L A+ A P + R+ R V +P+ GL+ + +V LDFRSLYPS+II
Sbjct: 2250 LHFAHPLR-YAMLSPSLSQVHRQPRIECIP-LVMQPKSGLYRHDPVVVLDFRSLYPSLII 2307
Query: 416 THNVSPDT------------------LNRENCKEYDVAPQVG--HRFCKDFP-------- 447
+N+ T + N ++ P G H P
Sbjct: 2308 AYNLCYSTCLGIVQPHSHGRLGVLPRFRQSNAALAELLPDDGTQHDGVVFSPNGAMFVPP 2367
Query: 448 ----GFIPSLLGNLLEERQKIKKRMKE----SKDPVEKKLLDYRQRAIKILANSYYGYYG 499
G +P ++ +L+ R +++ +K S D ++ L +Q A+K+LAN YGY
Sbjct: 2368 STRVGLLPQMVQAVLDTRFEVQAALKHIAVPSGDITMQQRLQEQQLALKMLANVTYGYTA 2427
Query: 500 YA-KARWYCKECAESVTAWGRQ----YIDLVRRELESRGFKVLYIDTDGLYATIPGAKHE 554
+ R C + AE++ + GRQ I+L+ R +V+Y DTD L+ + G
Sbjct: 2428 ASYTGRMPCVDLAEAIVSLGRQTLERTIELIHNTPAWRA-EVVYGDTDSLFVRLAGRTKA 2486
Query: 555 EIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYA------LIDEEGKIVTRGL 608
+ + + + P + L++E + KK+YA E + +G+
Sbjct: 2487 DAFRIGQEMADAVTRSSPAPIRLQFEKVLLPCLLLVKKRYAGYMWSSPTQEAPTFLAKGI 2546
Query: 609 EIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKYEIPPEKLVIYEQITR 668
E+VRRD + ++L +L + + E+L P + + +
Sbjct: 2547 EVVRRDQCPATAQLTDRLLRLLLDDASATVLRQSYYAAVERLQSGAANPLQCIFRRAV-- 2604
Query: 669 PLSEYK-AIGPHVAVAKRLAAKGVKVKP------GMVIGYIVLRGDGPISKRAIAIEEFD 721
L YK A H+ +A RLA + ++ G + Y+V+R +K + +
Sbjct: 2605 KLGRYKDADDTHLPLAARLAFQQMEKDATQTPCWGERLPYVVVRSTTATNK--LTDKVLH 2662
Query: 722 PKK-------HKYDAEYYIENQVLPAVERILRAFG 749
P++ H DA YYI V ++R+ G
Sbjct: 2663 PERLLQVHDTHSLDATYYIVRHVNRTLDRMFYLVG 2697
>pir||T21712 hypothetical protein F33H2.5 - Caenorhabditis elegans
>gi|3876643|emb|CAB04263.1| (Z81526) predicted using
Genefinder~contains similarity to Pfam domain: PF00136
(DNA polymerase family B), Score=39.6, E-value=7.8e-12,
N=3~cDNA EST yk317g9.5 comes from this gene~cDNA EST
yk433e2.5 comes from this gene~cDNA EST yk467e10.5 comes
from t>
Length = 2144
Score = 90.1 bits (220), Expect = 8e-17
Identities = 103/382 (26%), Positives = 168/382 (43%), Gaps = 63/382 (16%)
Query: 106 VVDIFEYDIPFAKRYLID-----------KGLTPMEG-----------NEELTFLAVDIE 143
+VDI EYD+PF R ID KG+ P + + LA DIE
Sbjct: 202 IVDIREYDVPFHMRVSIDEKIFVGLWYDVKGIGPNRVPTIKRKDLPLFHAKPKVLAFDIE 261
Query: 144 T--LYHEGEEFGKGPIIMISY-ADEEGAKVITWKSIDL--------PYVEVVSS------ 186
T L + + I+MISY D G +I + + P E +
Sbjct: 262 TTKLPLKFPDRESDEIMMISYMVDGRGFLIINREIVSADINAFEYTPKAEYIGEFTVWNE 321
Query: 187 --EREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRM 244
E +I++ + P++++TYNGD FD+P++ RA+ G N E ++
Sbjct: 322 KDEAALIRKFFDHFLQVRPNIVVTYNGDFFDWPFVEARAKIRGF-------NMEREIGFS 374
Query: 245 GDSLAVEIKGR--IHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
DS A E K R IH D F ++R LP + L+AV +A +V + +
Sbjct: 375 KDS-ADEYKSRNCIHMDAFRWVKRDSYLPVGSQNLKAVTKAKLRYDPVEVEPELMCKM-- 431
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLR 359
+ +++A YS+ DA T+ L ++ L ++ DV R +G L E L+
Sbjct: 432 AREQPQQLANYSVSDAVSTYYLYMKYVHQFIFALCTIIPLGADDVLRKGSGTLCEALLMV 491
Query: 360 KAYERNELAPNK---PDEREY----ERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPS 412
+A+ N + PNK P+E + R E+Y GG+V+ E G++ + FR P+
Sbjct: 492 EAFHNNIVFPNKYTGPEETRFSKDGHRVESETYVGGHVEALEAGVFRADIPAKFRLSVPA 551
Query: 413 IIITHNVSPDTLNRENCKEYDV 434
+ + +TL +E +E++V
Sbjct: 552 LEQLKSEIQETLRKELAREFEV 573
>gi|6324067 DNA polymerase II; Pol2p [Saccharomyces cerevisiae]
>gi|118841|sp|P21951|DPOE_YEAST DNA POLYMERASE EPSILON,
CATALYTIC SUBUNIT A (DNA POLYMERASE II SUBUNIT A)
>gi|101496|pir||A36028 DNA-directed DNA polymerase (EC
2.7.7.7) II catalytic chain - yeast (Saccharomyces
cerevisiae) >gi|171409|gb|AAA88711.1| (M60416) DNA
polymerase II [Saccharomyces cerevisiae]
>gi|1302317|emb|CAA96169.1| (Z71538) ORF YNL262w
[Saccharomyces cerevisiae]
Length = 2222
Score = 85.0 bits (207), Expect = 3e-15
Identities = 97/366 (26%), Positives = 166/366 (44%), Gaps = 64/366 (17%)
Query: 98 EKIREHPAVVDIFEYDIPFAKRYLIDKGLTP-----------MEGNEELTF-----LAVD 141
EK+ + DI EYD+P+ R IDK + +E ++ F +A D
Sbjct: 231 EKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFD 290
Query: 142 IETLYH--EGEEFGKGPIIMISYADEEGAKVITWKSI--------------DLPYVEVVS 185
IET + + I+MISY + +IT + I + P +
Sbjct: 291 IETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIF 350
Query: 186 SERE---MIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQ 242
+E + +++R + IR+ P VI T+NGD FD+P++ R++ G+ +
Sbjct: 351 NENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDM----------FD 400
Query: 243 RMGDSLAVEIKGRI------HFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHE 294
+G A + +G H D F ++R LP + L+AV ++ G + ++ E
Sbjct: 401 EIG--FAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIEL-DPE 457
Query: 295 IAEAWETGKGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLV 353
+ + K + +++YS+ DA T+ L ++ P L ++ + R TG L
Sbjct: 458 LMTPYAFEKP-QHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLC 516
Query: 354 EWFLLRKAYERNELAPNK---PDEREYERRLRES--YEGGYVKEPEKGLWEGIVSLDFRS 408
E L+ +AY+ N L PNK P ER Y+ L ES Y GG+V+ E G++ + +F+
Sbjct: 517 EMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESLEAGVFRSDLKNEFK- 575
Query: 409 LYPSII 414
+ PS I
Sbjct: 576 IDPSAI 581
>emb|CAA63235.1| (X92494) ORF N0825 [Saccharomyces cerevisiae]
Length = 2221
Score = 85.0 bits (207), Expect = 3e-15
Identities = 97/366 (26%), Positives = 166/366 (44%), Gaps = 64/366 (17%)
Query: 98 EKIREHPAVVDIFEYDIPFAKRYLIDKGLTP-----------MEGNEELTF-----LAVD 141
EK+ + DI EYD+P+ R IDK + +E ++ F +A D
Sbjct: 231 EKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFD 290
Query: 142 IETLYH--EGEEFGKGPIIMISYADEEGAKVITWKSI--------------DLPYVEVVS 185
IET + + I+MISY + +IT + I + P +
Sbjct: 291 IETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIF 350
Query: 186 SERE---MIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQ 242
+E + +++R + IR+ P VI T+NGD FD+P++ R++ G+ +
Sbjct: 351 NENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDM----------FD 400
Query: 243 RMGDSLAVEIKGRI------HFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHE 294
+G A + +G H D F ++R LP + L+AV ++ G + ++ E
Sbjct: 401 EIG--FAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIEL-DPE 457
Query: 295 IAEAWETGKGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLV 353
+ + K + +++YS+ DA T+ L ++ P L ++ + R TG L
Sbjct: 458 LMTPYAFEKP-QHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLC 516
Query: 354 EWFLLRKAYERNELAPNK---PDEREYERRLRES--YEGGYVKEPEKGLWEGIVSLDFRS 408
E L+ +AY+ N L PNK P ER Y+ L ES Y GG+V+ E G++ + +F+
Sbjct: 517 EMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESLEAGVFRSDLKNEFK- 575
Query: 409 LYPSII 414
+ PS I
Sbjct: 576 IDPSAI 581
>sp|P87154|DPOE_SCHPO DNA POLYMERASE EPSILON, CATALYTIC SUBUNIT A (DNA POLYMERASE II
SUBUNIT A) >gi|7490195|pir||T40008 Cdc20p - fission
yeast (Schizosaccharomyces pombe)
>gi|2104462|emb|CAB08772.1| (Z95397) dna polymerase
epsilon, catalytic subunit a [Schizosaccharomyces pombe]
Length = 2199
Score = 81.1 bits (197), Expect = 4e-14
Identities = 103/381 (27%), Positives = 170/381 (44%), Gaps = 68/381 (17%)
Query: 91 QDVPAIREKIREHPA--VVDIFEYDIPFAKRYLIDKGL--------TPMEGNEEL----- 135
+++ I E E P V+DI EYD+P+ R LID + + EG+ ++
Sbjct: 204 ENLNGIIENAFEDPLNHVLDIREYDVPYHSRTLIDLNIRVGQWYTVSYHEGHVQISLLAS 263
Query: 136 -------TFLAVDIET----LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVE-- 182
T +A DIET L F K I+MISY + +IT + I +E
Sbjct: 264 RIERAEPTIMAFDIETTKLPLKFPDSSFDK--IMMISYMIDGQGFLITNREIISQNIEDF 321
Query: 183 ------------VVSSERE---MIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLG 227
++ +E + ++ R K IR P VI+TYNGD FD+P++ RA G
Sbjct: 322 HYTPREEFEGPFIIFNEPDEVGLLHRFFKHIRSAKPSVIVTYNGDFFDWPFVDARAAFHG 381
Query: 228 IKLPLGRDNSEPKMQRMGDSLAVEIKGRI--HFDLFPVIRRTINLP--TYTLEAVYEAIF 283
+ L E R + E K H D F ++R LP + L+AV +
Sbjct: 382 LNL-----TEETGFFRDAED---EYKSSYCSHMDAFRWVKRDSYLPQGSQGLKAVTVSKL 433
Query: 284 GKSKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVW 342
G + ++ E+ + + K + +A+YS+ DA T+ L ++ P L ++
Sbjct: 434 GYNPIEL-DPELMTPYASEKP-QVLAQYSVSDAVATYFLYMKYVHPFIFSLCNIIPLNPD 491
Query: 343 DVSRSSTGNLVEWFLLRKAYERNELAPNK---PDEREYERRL--RESYEGGYVKEPEKGL 397
+V R TG L E L +A +N + PNK ++ ++ L E+Y GG+V+ E G+
Sbjct: 492 EVLRKGTGTLCETLLTVEACTKNIILPNKHVDASQKFFDGHLLASETYVGGHVESLESGV 551
Query: 398 WEGIVSLDFR---SLYPSIII 415
+ + +F +Y +I+
Sbjct: 552 FRSDLPTNFNMDPKVYEELIL 572
>gi|9631050 DNA polymerase [Lymantria dispar nucleopolyhedrovirus]
>gi|7434802|pir||T30431 DNA-directed DNA polymerase (EC
2.7.7.7) - Lymantria dispar nuclear polyhedrosis virus
>gi|3822318|gb|AAC70269.1|AAC70269 (AF081810) DNA
polymerase [Lymantria dispar nucleopolyhedrovirus]
Length = 1014
Score = 77.3 bits (187), Expect = 6e-13
Identities = 95/413 (23%), Positives = 165/413 (39%), Gaps = 58/413 (14%)
Query: 384 SYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFC 443
+Y+GG V P+ G + +LDF +LYP+I++ V + +A
Sbjct: 527 TYKGGKVLSPKPGFNRWVATLDFNALYPTIMMWEGVCMSNV--------FIASDGNVYLD 578
Query: 444 KDFPGFIPSLLGNLLEERQKIKKRMKESK-DPVEKKLLDYRQRAIKILANSYYGYYGYAK 502
K+ P LL L E R + K + + + KL D Q A+K +ANS YGYYG
Sbjct: 579 KNVNAVNPKLLKTLSEMRVRYKGLRDQCEYNSFYYKLYDKIQNALKRIANSIYGYYGI-- 636
Query: 503 ARWYCKECAESVTAWGRQYIDLVRRELESR---------------GFKVLYIDTDGLYAT 547
+ K A +T GR + V ++E+ F V+Y DTD +
Sbjct: 637 ---FFKPLANYITKMGRGKLKEVVGKVEAMSDDPRILREFGLSKINFSVIYGDTDSCFIR 693
Query: 548 I--------PGAKHEEIKEKALKFV-EYINSKLPGLLELEYEGFYARGFFVTKKKYALID 598
+ P + I+ V + +N G ++ E + KKKY ++
Sbjct: 694 VLFDEAELAPDRRQTAIRSIVQDHVCKTLNDSWCG-YKMSLENIMLSLILLKKKKYCYLN 752
Query: 599 EEGKIVTRGLEIVRRDWSEIAKETQAKVLEAILK-HGNVDEAVKIVKEVTEKLSKYEIPP 657
E + +G +++RD ++ ++++L+ H + +++ ++ P
Sbjct: 753 NEQRTKYKGW-LIKRDMPLFMRKAFRATVDSLLRGHSTACALGLLAEQMLRYYREFGAPR 811
Query: 658 EKLVIY----------EQITRPLSEYKAIGPHVAVAKR----LAAKGVKVKPGM--VIGY 701
E LV Y R E A P + +AK LA GV PG I Y
Sbjct: 812 ENLVDYCFSMSYNETSTTAKRRKEEDPARKPVITIAKHCRELLANPGVDFLPGNGDRIQY 871
Query: 702 IVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVL-PAVERILRAFGYRKE 753
+++ I+++A ++ FDP + +L + +++ FG R E
Sbjct: 872 VLVDVKEKITQKAFPLKLFDPDSPTLQISWLKHMNILCTFMNELIQVFGNRPE 924
>gi|5453926 polymerase (DNA directed), epsilon [Homo sapiens]
>gi|3192938|gb|AAC19148.1| (L09561) DNA polymerase
epsilon, catalytic polypeptide [Homo sapiens]
Length = 2286
Score = 76.1 bits (184), Expect = 1e-12
Identities = 88/353 (24%), Positives = 152/353 (42%), Gaps = 60/353 (16%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 218 IVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIE 277
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS---------------- 185
T L + + I+MISY + +IT + I +E
Sbjct: 278 TTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 337
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRM 244
E +I+R + ++E P +++TYNGD FD+P++ RA G+ + + +
Sbjct: 338 PDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSM---QQEIGFQKDSQ 394
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWETG 302
G+ A + IH D ++R LP ++ L+A +A G ++ ++
Sbjct: 395 GEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRM--AT 449
Query: 303 KGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKA 361
+ + +A YS+ DA T+ L ++ P L ++ +V R +G L E L+ +A
Sbjct: 450 EQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQA 509
Query: 362 YERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 510 FHANIIFPNK-QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFR 561
>gb|AAD44690.1| (AF127975) DNA polymerase epsilon catalytic subunit protein isoform
a [Homo sapiens]
Length = 2297
Score = 76.1 bits (184), Expect = 1e-12
Identities = 88/353 (24%), Positives = 152/353 (42%), Gaps = 60/353 (16%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 229 IVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIE 288
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS---------------- 185
T L + + I+MISY + +IT + I +E
Sbjct: 289 TTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 348
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRM 244
E +I+R + ++E P +++TYNGD FD+P++ RA G+ + + +
Sbjct: 349 PDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSM---QQEIGFQKDSQ 405
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWETG 302
G+ A + IH D ++R LP ++ L+A +A G ++ ++
Sbjct: 406 GEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRM--AT 460
Query: 303 KGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKA 361
+ + +A YS+ DA T+ L ++ P L ++ +V R +G L E L+ +A
Sbjct: 461 EQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQA 520
Query: 362 YERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 521 FHANIIFPNK-QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFR 572
>gb|AAD44691.1| (AF127975) DNA polymerase epsilon catalytic subunit protein isoform
b [Homo sapiens]
Length = 2286
Score = 76.1 bits (184), Expect = 1e-12
Identities = 88/353 (24%), Positives = 152/353 (42%), Gaps = 60/353 (16%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 218 IVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIE 277
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS---------------- 185
T L + + I+MISY + +IT + I +E
Sbjct: 278 TTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 337
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRM 244
E +I+R + ++E P +++TYNGD FD+P++ RA G+ + + +
Sbjct: 338 PDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSM---QQEIGFQKDSQ 394
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWETG 302
G+ A + IH D ++R LP ++ L+A +A G ++ ++
Sbjct: 395 GEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRM--AT 449
Query: 303 KGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKA 361
+ + +A YS+ DA T+ L ++ P L ++ +V R +G L E L+ +A
Sbjct: 450 EQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQA 509
Query: 362 YERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 510 FHANIIFPNK-QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFR 561
>gb|AAD44692.1| (AF127975) DNA polymerase epsilon catalytic subunit protein isoform
c [Homo sapiens]
Length = 2243
Score = 76.1 bits (184), Expect = 1e-12
Identities = 88/353 (24%), Positives = 152/353 (42%), Gaps = 60/353 (16%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 175 IVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIE 234
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS---------------- 185
T L + + I+MISY + +IT + I +E
Sbjct: 235 TTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 294
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRM 244
E +I+R + ++E P +++TYNGD FD+P++ RA G+ + + +
Sbjct: 295 PDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSM---QQEIGFQKDSQ 351
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWETG 302
G+ A + IH D ++R LP ++ L+A +A G ++ ++
Sbjct: 352 GEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRM--AT 406
Query: 303 KGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKA 361
+ + +A YS+ DA T+ L ++ P L ++ +V R +G L E L+ +A
Sbjct: 407 EQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQA 466
Query: 362 YERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 467 FHANIIFPNK-QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFR 518
>gb|AAD45244.1|AF123502_1 (AF123502) DNA polymerase epsilon catalytic subunit [Mus musculus]
Length = 2284
Score = 74.9 bits (181), Expect = 3e-12
Identities = 91/355 (25%), Positives = 153/355 (42%), Gaps = 64/355 (18%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 218 IVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRGNAFPVEITRRDDLVERPDPVVLAFDIE 277
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS---------------- 185
T L + + I+MISY + +IT + I +E
Sbjct: 278 TTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 337
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQR- 243
E +I+R + I+E P +++TYNGD FD+P++ RA G+ + E Q+
Sbjct: 338 PDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSM-----YQEIGFQKD 392
Query: 244 -MGDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
G+ A + IH D ++R LP ++ L+A +A G ++ ++
Sbjct: 393 SQGEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRM-- 447
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLR 359
+ + +A YS+ DA T+ L ++ P L ++ +V R +G L E L+
Sbjct: 448 ATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMV 507
Query: 360 KAYERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+A+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 508 QAFHANIIFPNK-QEQEFNKLTDDGHVLDAETYVGGHVEALESGVFRSDIPCRFR 561
>gi|6755124 DNA polymerase epsilon [Mus musculus] >gi|5669844|gb|AAD46482.1|
(AF126398) DNA polymerase epsilon catalytic subunit [Mus
musculus]
Length = 2283
Score = 74.1 bits (179), Expect = 5e-12
Identities = 92/355 (25%), Positives = 153/355 (42%), Gaps = 64/355 (18%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 218 IVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRGNAFPVEITRRDDLVERPDPVVLAFDIE 277
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSI---DLPYVEVV-------------- 184
T L + I+MISY + +IT + I D+ E
Sbjct: 278 TTKLPLTFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 337
Query: 185 SSEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQR- 243
E +I+R + I+E P +++TYNGD FD+P++ RA G+ + E Q+
Sbjct: 338 PDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSM-----YQEIGFQKD 392
Query: 244 -MGDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWE 300
G+ A + IH D ++R LP ++ L+A +A G ++ ++
Sbjct: 393 SQGEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRM-- 447
Query: 301 TGKGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLR 359
+ + +A YS+ DA T+ L ++ P L ++ +V R +G L E L+
Sbjct: 448 ATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMV 507
Query: 360 KAYERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+A+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 508 QAFHANIIFPNK-QEQEFNKLTDDGHVLDAETYVGGHVEALESGVFRSDIPCRFR 561
>sp|Q07864|DPOE_HUMAN DNA POLYMERASE EPSILON, CATALYTIC SUBUNIT A (DNA POLYMERASE II
SUBUNIT A) >gi|422808|pir||A46692 DNA-directed DNA
polymerase (EC 2.7.7.7) epsilon catalytic chain - human
>gi|303157|gb|AAA15448.1| (S60080) DNA polymerase
epsilon catalytic subunit [human, HeLa cells, Peptide,
2257 aa]
Length = 2257
Score = 73.0 bits (176), Expect = 1e-11
Identities = 90/353 (25%), Positives = 151/353 (42%), Gaps = 62/353 (17%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 191 IVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIE 250
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS---------------- 185
T L + + I+MISY + +IT + I +E
Sbjct: 251 TTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 310
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRM 244
E +I+R + ++E P +++TYNGD FD+P++ RA G+ + + +
Sbjct: 311 PDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSM---QQEIGFQKDSQ 367
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWETG 302
G+ A + IH D ++R LP ++ L+A + G ++ A + E
Sbjct: 368 GEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAASKL-GYDPVELDPETCAGSTEQP 423
Query: 303 KGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKA 361
+ L A YS+ DA T+ L ++ P L ++ +V R +G L E L+ +A
Sbjct: 424 QTL---ATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQA 480
Query: 362 YERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 481 FHANIIFPNK-QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFR 532
>pir||G02434 DNA-directed DNA polymerase (EC 2.7.7.7) epsilon catalytic chain A
[validated] - human >gi|1206035|gb|AAA90924.1| (U49356)
DNA polymerase epsilon catalytic subunit [Homo sapiens]
Length = 2285
Score = 71.0 bits (171), Expect = 5e-11
Identities = 87/353 (24%), Positives = 151/353 (42%), Gaps = 61/353 (17%)
Query: 106 VVDIFEYDIPFAKRYLIDKGL-------TPMEGNE---ELT------------FLAVDIE 143
+VD+ EYD+P+ R ID + GN E+T LA DIE
Sbjct: 218 IVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIE 277
Query: 144 T--LYHEGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVS---------------- 185
T L + + I+MISY + +IT + I +E
Sbjct: 278 TTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNE 337
Query: 186 -SEREMIKRLVKVIREKDPDVIITYNGDNFDFPYLLKRAEKLGIKLPLGRDNSEPKMQRM 244
E +I+R + ++E P +++TYNGD FD+P++ RA G+ + + +
Sbjct: 338 PDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSM---QQEIGFQKDSQ 394
Query: 245 GDSLAVEIKGRIHFDLFPVIRRTINLP--TYTLEAVYEAIFGKSKEKVYAHEIAEAWETG 302
G+ A + IH D ++R LP ++ L+A + G ++ ++
Sbjct: 395 GEYKAPQC---IHMDCLRWVKRDSYLPVGSHNLKAAASKL-GYDPVELDPEDMCRM--AT 448
Query: 303 KGLERVAKYSMEDAKVTFELGKEF-FPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKA 361
+ + +A YS+ DA T+ L ++ P L ++ +V R +G L E L+ +A
Sbjct: 449 EQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQA 508
Query: 362 YERNELAPNKPDEREYERRL-------RESYEGGYVKEPEKGLWEGIVSLDFR 407
+ N + PNK E+E+ + E+Y GG+V+ E G++ + FR
Sbjct: 509 FHANIIFPNK-QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFR 560
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.140 0.406
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 298399438
Number of Sequences: 2977
Number of extensions: 13344080
Number of successful extensions: 37807
Number of sequences better than 1.0e-10: 321
Number of HSP's better than 0.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 264
Number of HSP's that attempted gapping in prelim test: 36254
Number of HSP's gapped (non-prelim): 687
length of query: 771
length of database: 189,106,746
effective HSP length: 57
effective length of query: 714
effective length of database: 154,992,987
effective search space: 110664992718
effective search space used: 110664992718
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 169 (70.2 bits)