BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1149 (pyrC) DE:dihydroorotase (pyrC)
(404 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UXV6|PYRC_PYRAB DIHYDROOROTASE (DHOASE) >gi|7435957|pir||C7... 827 0.0
sp|O57740|PYRC_PYRHO DIHYDROOROTASE (DHOASE) >gi|7435952|pir||C7... 725 0.0
gi|11499831 dihydroorotase (pyrC) [Archaeoglobus fulgidus] >gi|3... 253 2e-66
sp|O27199|PYRC_METTH DIHYDROOROTASE (DHOASE) >gi|7435953|pir||A6... 240 3e-62
sp|Q58885|PYRC_METJA DIHYDROOROTASE (DHOASE) >gi|2127849|pir||A6... 222 6e-57
sp|P08955|PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT ... 218 1e-55
gb|AAA37009.1| (M33702) dihydroorotase synthetase complex (EC 3.... 218 1e-55
gb|AAA37073.1| (M28866) S-dihydroorotate amidohydrolase (DHOase)... 218 1e-55
gb|AAF48639.2| (AE003503) CG18572 gene product [Drosophila melan... 216 3e-55
dbj|BAA22615.1| (AB007768) dihydroorotase [Rattus rattus] 214 1e-54
gi|4757896 carbamoyl-phosphate synthetase 2, aspartate transcarb... 212 5e-54
pir||T45151 dihydroorotase (EC 3.5.2.3) [imported] - Methanobact... 210 2e-53
sp|Q91437|PYR1_SQUAC CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT ... 209 4e-53
pir||QZDOP3 pyrimidine synthesis protein PYR1-3 - slime mold (D... 205 6e-52
sp|P20054|PYR1_DICDI PROTEIN PYR1-3 [INCLUDES: GLUTAMINE-DEPENDE... 205 6e-52
emb|CAA32782.1| (X14634) PYR1-3B multifunctional enzyme (1014 AA... 205 6e-52
pir||T20371 hypothetical protein D2085.1 - Caenorhabditis elegan... 195 7e-49
pir||D82736 dihydroorotase XF0988 [imported] - Xylella fastidios... 182 7e-45
gb|AAG20592.1| (AE005129) dihydroorotase; PyrC [Halobacterium sp... 178 8e-44
sp|P05990|PYR1_DROME CAD PROTEIN (RUDIMENTARY PROTEIN) [INCLUDES... 176 3e-43
emb|CAA28502.1| (X04813) CAD protein (AA 1 - 2236) [Drosophila m... 176 3e-43
dbj|BAB06257.1| (AP001515) dihydroorotase [Bacillus halodurans] 172 7e-42
sp|P46538|PYRC_BACCL DIHYDROOROTASE (DHOASE) >gi|2118165|pir||I4... 169 4e-41
sp|O66990|PYRC_AQUAE DIHYDROOROTASE (DHOASE) >gi|7435951|pir||C7... 168 8e-41
dbj|BAA94294.1| (AB029444) Dihydroorotase [Leishmania mexicana a... 166 4e-40
dbj|BAB06028.1| (AP001515) allantoinase [Bacillus halodurans] 163 3e-39
gb|AAF68548.1|AF252765_1 (AF252765) rudimentary [Drosophila simu... 161 1e-38
gb|AAF68549.1|AF252766_1 (AF252766) rudimentary [Drosophila simu... 161 1e-38
gb|AAG02130.1|AF146701_6 (AF146701) L-hydantoinase HyuH [Arthrob... 158 1e-37
sp|P77884|PYRC_LACPL DIHYDROOROTASE (DHOASE) >gi|1514601|emb|CAA... 156 4e-37
sp|P81006|HYDA_ARTAU D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPASE) 155 6e-37
emb|CAB93366.1| (AL357523) dihydroorotase [Streptomyces coelicol... 154 2e-36
sp|P77671|ALN_ECOLI ALLANTOINASE >gi|7428266|pir||G64782 probabl... 153 3e-36
sp|Q9UX05|PYRC_SULSO DIHYDROOROTASE (DHOASE) >gi|6015862|emb|CAB... 153 4e-36
gb|AAK40922.1| Dihydroorotase (carbamoylaspartic dehydrase) (DHO... 153 4e-36
sp|Q9RV76|ALN_DEIRA PROBABLE ALLANTOINASE >gi|7473401|pir||E7542... 150 4e-35
pir||T30519 dihydroorotase (EC 3.5.2.3) - Trypanosoma cruzi >gi|... 146 3e-34
sp|P25995|PYRC_BACSU DIHYDROOROTASE (DHOASE) >gi|279573|pir||DEB... 145 1e-33
sp|P48795|PYRC_LACLE DIHYDROOROTASE (DHOASE) >gi|11266161|pir||T... 143 3e-33
emb|CAC12440.1| (AL445067) cad protein (human), dihydroorotase d... 143 4e-33
pir||B82954 probable dihydroorotase PA5541 [imported] - Pseudomo... 142 8e-33
sp|P96081|PYRC_THEAQ DIHYDROOROTASE (DHOASE) >gi|1684761|emb|CAA... 140 2e-32
emb|CAC14834.1| (AJ295151) putative allantoinase [Staphylococcus... 140 2e-32
sp|Q9RVC3|PYRC_DEIRA DIHYDROOROTASE (DHOASE) >gi|7471807|pir||E7... 139 4e-32
sp|Q44184|HYDA_AGRRD D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPAS... 130 3e-29
sp|P71809|PYRC_MYCTU DIHYDROOROTASE (DHOASE) >gi|7435956|pir||B7... 129 4e-29
sp|O08357|PYRC_SULAC DIHYDROOROTASE (DHOASE) >gi|2065441|emb|CAA... 129 4e-29
sp|Q9RKU5|ALN_STRCO PROBABLE ALLANTOINASE >gi|6273652|emb|CAB601... 127 2e-28
gb|AAF48826.1| (AE003508) CG6106 gene product [Drosophila melano... 123 3e-27
sp|O32137|ALN_BACSU PROBABLE ALLANTOINASE >gi|7428265|pir||C7001... 123 3e-27
gi|6322218 allantoinase; Dal1p [Saccharomyces cerevisiae] >gi|72... 120 2e-26
gb|AAA34553.1| (M69294) alantoinase [Saccharomyces cerevisiae] 116 6e-25
sp|Q45515|HYDA_BACST D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPAS... 112 6e-24
sp|Q9WYH0|PYRC_THEMA DIHYDROOROTASE (DHOASE) >gi|7462364|pir||A7... 111 1e-23
sp|Q9YFI5|PYRC_AERPE DIHYDROOROTASE (DHOASE) >gi|7435958|pir||F7... 111 1e-23
pir||T28685 hypothetical protein - Streptomyces coelicolor >gi|3... 109 7e-23
sp|Q59699|HYDA_PSEPU D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPAS... 104 2e-21
sp|Q46806|YGEZ_ECOLI HYPOTHETICAL 51.5 KD PROTEIN IN PBL-LYSS IN... 103 3e-21
pir||H83590 dihydropyrimidinase PA0441 [imported] - Pseudomonas ... 102 9e-21
dbj|BAB10038.1| (AB007727) dihydropyrimidinase [Arabidopsis thal... 97 4e-19
pir||G83595 noncatalytic dihydroorotase-like protein PA0401 [imp... 93 5e-18
gb|AAD09129.1| (AF112473) PyrABCN [Aspergillus nidulans] 92 1e-17
sp|Q51551|PYRX_PSEAE DIHYDROOROTASE-LIKE PROTEIN (ASPARTATE CARB... 90 4e-17
gb|AAD18071.1| (AF129814) carbamyl phosphate synthetase II; CPS.... 87 5e-16
sp|Q09794|PYR1_SCHPO URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT... 85 1e-15
pir||S65074 pyrimidine synthesis protein URA1 - fission yeast (... 85 1e-15
emb|CAB95124.1| (AJ251275) hypothetical protein [Homo sapiens] 81 2e-14
emb|CAA69153.1| (Y07818) ULIP [Homo sapiens] 80 6e-14
gi|9910168 collapsin response mediator protein-5; CRMP3-associat... 79 8e-14
gb|AAG37998.1|AF249295_1 (AF249295) collapsin response mediator ... 79 1e-13
gi|4503379 dihydropyrimidinase-like 3 [Homo sapiens] >gi|3122050... 78 2e-13
gi|4503375 dihydropyrimidinase [Homo sapiens] >gi|3122049|sp|Q14... 78 2e-13
sp|Q63150|DPYS_RAT DIHYDROPYRIMIDINASE (DHPASE) (HYDANTOINASE) (... 77 4e-13
gi|6681219 dihydropyrimidinase-like 3; unc-33-like phosphoprotei... 76 5e-13
gi|11416486 dihydropyrimidinase-like 3 [Homo sapiens] 76 5e-13
gb|AAF04317.1| (AF150928) dihydropyrimidinase homolog [Acinetoba... 74 3e-12
gb|AAA35198.1| (J04711) carbamylase phosphate synthetase-asparta... 74 3e-12
sp|Q90635|DPY2_CHICK DIHYDROPYRIMIDINASE RELATED PROTEIN-2 (DRP-... 73 5e-12
gb|AAA68280.1| (M27174) carbamyl phosphate synthetase [Saccharom... 71 2e-11
emb|CAA60825.1| (X87371) carbamyl phosphate synthetase [Saccharo... 71 2e-11
gi|6322331 carbamoyl-phophate synthetase, aspartate transcarbamy... 71 2e-11
gb|AAD46840.1|AF160900_1 (AF160900) BcDNA.HL02693 [Drosophila me... 71 2e-11
sp|Q18677|DPY1_CAEEL HYPOTHETICAL 56.3 KD PROTEIN C47E12.8 IN CH... 69 9e-11
>sp|Q9UXV6|PYRC_PYRAB DIHYDROOROTASE (DHOASE) >gi|7435957|pir||C75027 dihydroorotase
(pyrc) PAB1149 - Pyrococcus abyssi (strain Orsay)
>gi|5459171|emb|CAB50657.1| (AJ248288) dihydroorotase
(pyrC) [Pyrococcus abyssi]
Length = 404
Score = 827 bits (2113), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MELVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHL 60
MELVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHL
Sbjct: 1 MELVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHL 60
Query: 61 RDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALG 120
RDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALG
Sbjct: 61 RDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALG 120
Query: 121 FLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPI 180
FLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPI
Sbjct: 121 FLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPI 180
Query: 181 VEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEK 240
VEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEK
Sbjct: 181 VEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEK 240
Query: 241 SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKERGAAGLPGLETEVALLLD 300
SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKERGAAGLPGLETEVALLLD
Sbjct: 241 SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKERGAAGLPGLETEVALLLD 300
Query: 301 AVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAG 360
AVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAG
Sbjct: 301 AVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAG 360
Query: 361 WTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVKEGDD 404
WTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVKEGDD
Sbjct: 361 WTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVKEGDD 404
>sp|O57740|PYRC_PYRHO DIHYDROOROTASE (DHOASE) >gi|7435952|pir||C71212 probable
dihydroorotase - Pyrococcus horikoshii
>gi|3258407|dbj|BAA31090.1| (AP000007) 417aa long
hypothetical dihydroorotase [Pyrococcus horikoshii]
Length = 417
Score = 725 bits (1852), Expect = 0.0
Identities = 338/403 (83%), Positives = 379/403 (93%)
Query: 1 MELVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHL 60
++LV+VGKFL+ +IIDGSIG++D KI KFSLRELKGD KIKVEKGKIILPGLIDVHVHL
Sbjct: 4 VDLVVVGKFLFKEKIIDGSIGIEDDKIAKFSLRELKGDKKIKVEKGKIILPGLIDVHVHL 63
Query: 61 RDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALG 120
RDFNE++KETI +GTKAA+HGGITTVFDMPNTKPP+MDEKTLK+RE +FKKKSY+DYALG
Sbjct: 64 RDFNESYKETIASGTKAAIHGGITTVFDMPNTKPPIMDEKTLKLRELIFKKKSYSDYALG 123
Query: 121 FLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPI 180
FL+AGNEP KADFYKIFMGASTGGIYSKNFEEDY KA DI SVHAE+YELI++YPERPPI
Sbjct: 124 FLIAGNEPAKADFYKIFMGASTGGIYSKNFEEDYKKAPDIVSVHAEEYELINRYPERPPI 183
Query: 181 VEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEK 240
VE+ AIKKAL A++K+KKPLHICHVST++GLKEIL+ANIPWVSFEVTPHHLFLTR+DYE+
Sbjct: 184 VEVVAIKKALQASKKMKKPLHICHVSTKDGLKEILKANIPWVSFEVTPHHLFLTRRDYER 243
Query: 241 SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKERGAAGLPGLETEVALLLD 300
SKLLKVYPPLRDE DRRYLWE L ++PIIASDHAPHTLEDKE GAAGLPGLETEVALLLD
Sbjct: 244 SKLLKVYPPLRDEEDRRYLWENLKSIPIIASDHAPHTLEDKEAGAAGLPGLETEVALLLD 303
Query: 301 AVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAG 360
AVN+GM+ +WD+V KMS+NPARIF+IKNKGW EGKDAD +VDMKKEWTIKAE FYTKA
Sbjct: 304 AVNKGMITIWDIVAKMSINPARIFKIKNKGWEEGKDADLIVVDMKKEWTIKAENFYTKAN 363
Query: 361 WTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVKEGD 403
WTPYEGWKV+GKVIMTILRGE+VMEDDE+IGKPRGERIVKEG+
Sbjct: 364 WTPYEGWKVKGKVIMTILRGEVVMEDDEIIGKPRGERIVKEGN 406
>gi|11499831 dihydroorotase (pyrC) [Archaeoglobus fulgidus]
>gi|3914507|sp|O28034|PYRC_ARCFU DIHYDROOROTASE (DHOASE)
>gi|7435954|pir||B69531 dihydroorotase (pyrC) homolog -
Archaeoglobus fulgidus >gi|2648275|gb|AAB89007.1|
(AE000949) dihydroorotase (pyrC) [Archaeoglobus
fulgidus]
Length = 403
Score = 253 bits (640), Expect = 2e-66
Identities = 154/423 (36%), Positives = 234/423 (54%), Gaps = 54/423 (12%)
Query: 7 GKFLYNGRIIDGSIGVKDGKITKFSL----RELKGDNKIKVEKGKIILPGLIDVHVHLRD 62
GK Y G ++ I V++G+I + +E+KG +ILP IDVHVHLRD
Sbjct: 4 GKVFYKGEFVEAGIEVENGRIKRIGKLVEGKEVKG----------VILPAGIDVHVHLRD 53
Query: 63 FNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFL 122
F E KETIETGT +A+HGGI V D PNTKPPV D +T R +K Y DYAL
Sbjct: 54 FAEKRKETIETGTLSALHGGICLVVDQPNTKPPVDDAETYFRRMGKAEKSVYVDYALNLA 113
Query: 123 LAGNE-----PVKADFYKIFMGASTGGIYSKNFEEDYAKALD------------ITSVHA 165
L + + + + + G ++ ++ ED + + ++HA
Sbjct: 114 LTNSNHGKIGSIMRKISERYFVPAVGEVFIQHDSEDLQIDYETLSSVYKRFEGVVFTIHA 173
Query: 166 EDYELISK----YPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPW 221
ED +++ + R E+ A+++ + + H CH+ST++ KEIL +N
Sbjct: 174 EDPAYVARGSPNFVFRRREAEVLAVERLVELGK-----FHFCHISTKDSAKEILNSN--- 225
Query: 222 VSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLED 280
++EVTPHH+ L+ +DY + L+ V PPLR+ D +L+ + ++ASDHAPHTLED
Sbjct: 226 STYEVTPHHMLLSVEDYGRLGNLVNVNPPLREREDVEWLFRNFHRIDVLASDHAPHTLED 285
Query: 281 KERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGE---GKDA 337
KE GA+G PG+ET L ++ ++G + +VEK++ NPARIF KG+GE G A
Sbjct: 286 KEAGASGFPGVETMYPLFVNLASKGYISFKTLVEKIASNPARIFGF--KGYGEIEVGNYA 343
Query: 338 DFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKV--RGKVIMTILRGEIVMEDDEVIGKPRG 395
+FA+ D+KK I+AE ++K GWTP+EG++ KV LRG+ ++E++ G
Sbjct: 344 NFAVFDLKKVDEIRAERLHSKCGWTPFEGFEAVFPDKV---YLRGKELLENEMKAGNVLK 400
Query: 396 ERI 398
+R+
Sbjct: 401 KRV 403
>sp|O27199|PYRC_METTH DIHYDROOROTASE (DHOASE) >gi|7435953|pir||A69017 dihydroorotase -
Methanobacterium thermoautotrophicum (strain Delta H)
>gi|2622230|gb|AAB85616.1| (AE000882) dihydroorotase
[Methanobacterium thermoautotrophicum]
Length = 454
Score = 240 bits (605), Expect = 3e-62
Identities = 151/413 (36%), Positives = 226/413 (54%), Gaps = 33/413 (7%)
Query: 19 SIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIETGTKAA 78
+IGV DGKI + S + KI + KG +LPGLID HVH RD +KE TG+ AA
Sbjct: 41 NIGVDDGKIVQISRGRIDASEKIDL-KGYFVLPGLIDAHVHFRDPGLEYKEDFRTGSMAA 99
Query: 79 VHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAGNEPVKADF----- 133
HGG +TV DMPNT PP + + + + ++KS D+ L VK
Sbjct: 100 AHGGFSTVLDMPNTVPPADNAAEFERKIRIGERKSVVDFGLHAGFRSVSDVKGILRFMPA 159
Query: 134 -YKIFMGASTGGIYSKNFEE--DYAKALDITSVHAEDYELISKYPE-------------- 176
+K+FM + F E D + + +T VH E+ +++ K +
Sbjct: 160 SFKVFMDLTGISTVDGLFRELKDLSAPVPVT-VHCENRDVVMKSMKELKDRSDPSAYALA 218
Query: 177 RPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTRK 236
RPP+ E ++ + L + + P+HICH+ST + L +++E +V+ EVTPHHL L
Sbjct: 219 RPPLAEEVSVAEVLALSIHHEHPVHICHLSTVKAL-QLVEPFREYVTCEVTPHHLLLDSG 277
Query: 237 DYEK-SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKERG----AAGLPGL 291
+ + ++K PPLR R Y E LD + II +DHAPH +E+K +G G+P L
Sbjct: 278 AFRRFGTMVKTNPPLRPPESRIYP-EFLDRINIIGTDHAPHGIEEKRKGIWDAPPGIPNL 336
Query: 292 ETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKG-WGEGKDADFAIVDMKKEWTI 350
E + LLL V++G + L + ++ PARIF +++KG EG DADF ++D+K+ I
Sbjct: 337 EVVLKLLLTLVSKGRMSLSTIRRMLAEEPARIFGLRSKGRIAEGMDADFTVIDLKETGRI 396
Query: 351 KAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVKEGD 403
+++EFY+KA +TP+EG+ G +MTI+RG VM D EV+ + G I E D
Sbjct: 397 RSDEFYSKAHYTPFEGFSYTGGPVMTIVRGRAVMRDGEVL-EGNGRYIPAEHD 448
>sp|Q58885|PYRC_METJA DIHYDROOROTASE (DHOASE) >gi|2127849|pir||A64486 dihydroorotase (EC
3.5.2.3) - Methanococcus jannaschii
>gi|1500377|gb|AAB99503.1| (U67590) dihydroorotase
(pyrC) [Methanococcus jannaschii]
Length = 423
Score = 222 bits (560), Expect = 6e-57
Identities = 149/417 (35%), Positives = 237/417 (56%), Gaps = 50/417 (11%)
Query: 8 KFLYNGRIIDGSIGV-KDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNET 66
+ + + +II+G I + ++G+I K + +++K D++I K +++PG+ID HVH R + E
Sbjct: 7 RIIKDNKIIEGDILIDENGRIKKIA-KDIKVDDEIIDIKNSLVIPGVIDAHVHFR-WGEE 64
Query: 67 HKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAGN 126
KE +G+ A ++GG+ DMPN KPP+ ++ + KK S + L F + N
Sbjct: 65 KKEDFLSGSLAGINGGVCFAIDMPNNKPPITTKELFYKKLEDCKKDSKINVFLNFGVTEN 124
Query: 127 EPV----KADFYKIFMGASTGGIYSKNFEEDYAKALDITS------VHAEDYELISKYPE 176
+ A YKIFM S G + F EDY+K DI + +HAE ++I++ +
Sbjct: 125 NYLGTVEDAKAYKIFMVKSVGDL----FIEDYSKLKDILNQNKLFCIHAEHKDVINENLK 180
Query: 177 RPPI-------------VEISAIKKALNAARKV-----KKP-LHICHVSTREGLKEILEA 217
+ + E+ A+K+ + + + KKP +H CH+ST+E L I +
Sbjct: 181 KYQLNSWIDHCKIRDEKSEVEAVKEVIKNLKIIDRQSNKKPHVHFCHISTKEALYLIKKV 240
Query: 218 -----NIPWVSFEVTPHHLFLTRKDYEKSKLL-KVYPPLRDESDRRYLWEKLDN--VPII 269
NI ++ EVTPHH++L + E+ K K PPLR++ D L + + N V II
Sbjct: 241 RQELKNIK-ITVEVTPHHIYLNKDMAEELKGFGKFNPPLREKDDNIALIKGIVNKDVDII 299
Query: 270 ASDHAPHTLEDKERGA----AGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFR 325
ASDHAPH LEDK + +G+PG+ET V L L+ VN+G++ L+D + +S NPA+IF
Sbjct: 300 ASDHAPHLLEDKLKNVKNCPSGIPGIETIVPLTLNLVNKGLISLFDAIRVLSKNPAKIFN 359
Query: 326 IKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEI 382
I NK EG A+ I+D+KKE I AE F +KA ++P++GW+V+G I T++ G +
Sbjct: 360 INNK-IEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGWEVKGFPIYTVINGTL 415
>sp|P08955|PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ] >gi|538556|pir||A23443 pyrimidine
synthesis multifunctional protein CAD - golden hamster
Length = 2225
Score = 218 bits (549), Expect = 1e-55
Identities = 139/354 (39%), Positives = 200/354 (56%), Gaps = 24/354 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPGLIDVHVHLR+ THKE +GT AA+ GG+T V MPNT+PP++D L + + L
Sbjct: 1464 LPGLIDVHVHLREPGGTHKEDFASGTAAALAGGVTMVCAMPNTRPPIIDAPALALAQKLA 1523
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
+ + D+AL FL A +E A G++ G K + + L + SV A+ E
Sbjct: 1524 EAGARCDFAL-FLGASSE--NAGTLGAVAGSAAG---LKLYLNETFSELRLDSV-AQWME 1576
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWVS 223
+P PIV E ++ L A+ ++P+HICHV+ +E + I A +P V+
Sbjct: 1577 HFETWPSHLPIVAHAERQSVAAVLMVAQLTQRPVHICHVARKEEILLIKTAKAQGLP-VT 1635
Query: 224 FEVTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK 281
EV PHHLFL R+D E+ +V P L D LWE + + ASDHAPHTLE+K
Sbjct: 1636 CEVAPHHLFLNREDLERLGPGRGEVRPELGSREDMEALWENMAVIDCFASDHAPHTLEEK 1695
Query: 282 --ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADF 339
+ G PGLET + LLL AV+ G L L D+++++ NP RIF + ++ +
Sbjct: 1696 CGPKPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPL------QEDTY 1749
Query: 340 AIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD++ EWTI + ++KA WTP+EG KV+G + +LRGE+ D +V+ P
Sbjct: 1750 VEVDLEHEWTIPSHMPFSKARWTPFEGQKVKGTIRRVVLRGEVAYIDGQVLVPP 1803
>gb|AAA37009.1| (M33702) dihydroorotase synthetase complex (EC 3.5.2.3) [Cricetulus
sp.]
Length = 708
Score = 218 bits (549), Expect = 1e-55
Identities = 139/354 (39%), Positives = 200/354 (56%), Gaps = 24/354 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPGLIDVHVHLR+ THKE +GT AA+ GG+T V MPNT+PP++D L + + L
Sbjct: 62 LPGLIDVHVHLREPGGTHKEDFASGTAAALAGGVTMVCAMPNTRPPIIDAPALALAQKLA 121
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
+ + D+AL FL A +E A G++ G K + + L + SV A+ E
Sbjct: 122 EAGARCDFAL-FLGASSE--NAGTLGAVAGSAAG---LKLYLNETFSELRLDSV-AQWME 174
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWVS 223
+P PIV E ++ L A+ ++P+HICHV+ +E + I A +P V+
Sbjct: 175 HFETWPSHLPIVAHAERQSVAAVLMVAQLTQRPVHICHVARKEEILLIKTAKAQGLP-VT 233
Query: 224 FEVTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK 281
EV PHHLFL R+D E+ +V P L D LWE + + ASDHAPHTLE+K
Sbjct: 234 CEVAPHHLFLNREDLERLGPGRGEVRPELGSREDMEALWENMAVIDCFASDHAPHTLEEK 293
Query: 282 --ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADF 339
+ G PGLET + LLL AV+ G L L D+++++ NP RIF + ++ +
Sbjct: 294 CGPKPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPL------QEDTY 347
Query: 340 AIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD++ EWTI + ++KA WTP+EG KV+G + +LRGE+ D +V+ P
Sbjct: 348 VEVDLEHEWTIPSHMPFSKARWTPFEGQKVKGTIRRVVLRGEVAYIDGQVLVPP 401
>gb|AAA37073.1| (M28866) S-dihydroorotate amidohydrolase (DHOase) (EC 3.5.2.3)
[Mesocricetus auratus]
Length = 480
Score = 218 bits (549), Expect = 1e-55
Identities = 139/354 (39%), Positives = 200/354 (56%), Gaps = 24/354 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPGLIDVHVHLR+ THKE +GT AA+ GG+T V MPNT+PP++D L + + L
Sbjct: 74 LPGLIDVHVHLREPGGTHKEDFASGTAAALAGGVTMVCAMPNTRPPIIDAPALALAQKLA 133
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
+ + D+AL FL A +E A G++ G K + + L + SV A+ E
Sbjct: 134 EAGARCDFAL-FLGASSE--NAGTLGAVAGSAAG---LKLYLNETFSELRLDSV-AQWME 186
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWVS 223
+P PIV E ++ L A+ ++P+HICHV+ +E + I A +P V+
Sbjct: 187 HFETWPSHLPIVAHAERQSVAAVLMVAQLTQRPVHICHVARKEEILLIKTAKAQGLP-VT 245
Query: 224 FEVTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK 281
EV PHHLFL R+D E+ +V P L D LWE + + ASDHAPHTLE+K
Sbjct: 246 CEVAPHHLFLNREDLERLGPGRGEVRPELGSREDMEALWENMAVIDCFASDHAPHTLEEK 305
Query: 282 --ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADF 339
+ G PGLET + LLL AV+ G L L D+++++ NP RIF + ++ +
Sbjct: 306 CGPKPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPL------QEDTY 359
Query: 340 AIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD++ EWTI + ++KA WTP+EG KV+G + +LRGE+ D +V+ P
Sbjct: 360 VEVDLEHEWTIPSHMPFSKARWTPFEGQKVKGTIRRVVLRGEVAYIDGQVLVPP 413
>gb|AAF48639.2| (AE003503) CG18572 gene product [Drosophila melanogaster]
Length = 2188
Score = 216 bits (545), Expect = 3e-55
Identities = 134/353 (37%), Positives = 194/353 (53%), Gaps = 22/353 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPG IDVHVHLR+ THKE +GT AA+ GG+T V MPNT P ++D +T + L
Sbjct: 1443 LPGFIDVHVHLREPGATHKEDFASGTAAALAGGVTLVCAMPNTNPSIVDRETFTQFQELA 1502
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
K + DYAL + ++ A ++ A +Y N K D+TS
Sbjct: 1503 KAGARCDYAL--YVGASDDNWAQVNELASHACGLKMY-LNDTFGTLKLSDMTSWQRH--- 1556
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPW--VSF 224
+S +P+R PIV E + + A + + +HICHV+ +E ++ I A V+
Sbjct: 1557 -LSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSAKEKGVKVTC 1615
Query: 225 EVTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK- 281
EV PHHLFL+ KD E+ + +V P L D+ LWE +D + + A+DHAPHTL +K
Sbjct: 1616 EVCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKR 1675
Query: 282 -ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFA 340
ER G PG+ET + LLL AV+ G L + D+ K NP IF + ++ +
Sbjct: 1676 SERPPPGFPGVETILPLLLQAVHEGRLTMEDIKRKFHRNPKIIFNLPDQA------QTYV 1729
Query: 341 IVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD+ +EWTI E +K+GWTP+EG KV+G+V +LRGE+ D +V+ +P
Sbjct: 1730 EVDLDEEWTITGNEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVLVQP 1782
>dbj|BAA22615.1| (AB007768) dihydroorotase [Rattus rattus]
Length = 474
Score = 214 bits (540), Expect = 1e-54
Identities = 138/354 (38%), Positives = 198/354 (54%), Gaps = 24/354 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPGLIDVHVHLR+ THKE +GT AA+ GG+T V MPNT+PP++D L + + L
Sbjct: 68 LPGLIDVHVHLREPGGTHKEDFASGTAAALAGGVTMVCAMPNTRPPIIDAPALALAQKLA 127
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
+ + D+ L FL A +E A G++ G K + + L + SV A+ E
Sbjct: 128 EAGARCDFTL-FLGASSE--NAGTLGAVAGSAAG---LKLYLNETFSELRLDSV-AQWME 180
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWVS 223
+P PIV E ++ L A+ ++ +HICHV+ +E + I A +P V+
Sbjct: 181 HFETWPSHLPIVAHAERQSVAAVLMVAQLTRRSVHICHVARKEEILLIKTAKAQGLP-VT 239
Query: 224 FEVTPHHLFLTRKDYEKSKLLK--VYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK 281
EV PHHLFL R+D E+ K V P L D LWE + + ASDHAPHTLE+K
Sbjct: 240 CEVAPHHLFLNREDLERLGPGKGEVRPELGSREDMEALWENMAVIDCFASDHAPHTLEEK 299
Query: 282 --ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADF 339
+ G PGLET + LLL AV+ G L L D+++++ NP RIF + ++ +
Sbjct: 300 CGPKPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPL------QEDTY 353
Query: 340 AIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD++ EWT+ + ++KA WTP+EG KV+G V +LRGE+ D +V+ P
Sbjct: 354 VEVDLEHEWTVPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP 407
>gi|4757896 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and
dihydroorotase; CAD trifunctional protein of pyrimidine
biosynthesis [Homo sapiens]
>gi|1709955|sp|P27708|PYR1_HUMAN CAD PROTEIN [INCLUDES:
GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE ;
ASPARTATE CARBAMOYLTRANSFERASE ; DIHYDROOROTASE ]
>gi|1228049|dbj|BAA11423.1| (D78586) multifunctional
protein CAD [Homo sapiens]
Length = 2225
Score = 212 bits (535), Expect = 5e-54
Identities = 140/354 (39%), Positives = 196/354 (54%), Gaps = 24/354 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPGLIDVHVHLR+ THKE +GT AA+ GGIT V MPNT+PP++D L + + L
Sbjct: 1464 LPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDGPALALAQKLA 1523
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
+ + D+AL FL A +E A G++ G K + + L + SV + E
Sbjct: 1524 EAGARCDFAL-FLGASSE--NAGTLGTVAGSAAG---LKLYLNETFSELRLDSV-VQWME 1576
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWVS 223
+P PIV E + L A+ ++ +HICHV+ +E + I A +P V+
Sbjct: 1577 HFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLP-VT 1635
Query: 224 FEVTPHHLFLTRKDYEKSKLLK--VYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK 281
EV PHHLFL+ D E+ K V P L D LWE + + ASDHAPHTLE+K
Sbjct: 1636 CEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWEDMAVIDCFASDHAPHTLEEK 1695
Query: 282 --ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADF 339
R G PGLET + LLL AV+ G L L D+++++ NP RIF + ++ +
Sbjct: 1696 CGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHL------PPQEDTY 1749
Query: 340 AIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD++ EWTI + ++KA WTP+EG KV+G V +LRGE+ D +V+ P
Sbjct: 1750 VEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP 1803
>pir||T45151 dihydroorotase (EC 3.5.2.3) [imported] - Methanobacterium
thermoautotrophicum (fragment) >gi|517425|gb|AAA73440.1|
(U09990) dihydro-orotase [Methanobacterium
thermoautotrophicum]
Length = 430
Score = 210 bits (530), Expect = 2e-53
Identities = 143/414 (34%), Positives = 218/414 (52%), Gaps = 36/414 (8%)
Query: 19 SIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIETGTKAA 78
+IGV DGKI + S + KI + K +LPGLID HVH RD +KE TG+ AA
Sbjct: 18 NIGVDDGKIVQISRGRIDASEKIDL-KAYFVLPGLIDAHVHFRDPGLEYKEDFRTGSMAA 76
Query: 79 VHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAGNEPVKADF----- 133
HGG +TV DMPNT PP + + + + ++KS D+ L VK
Sbjct: 77 AHGGFSTVLDMPNTVPPADNAAEFERKIRIGERKSVVDFGLHAGFRSVSDVKGILRNMPA 136
Query: 134 -YKIFMGASTGGIYSKNFEE--DYAKALDITSVHAEDYELISKYPER------------- 177
+K+FM + F E D + + +T VH E+ +++ K +
Sbjct: 137 SFKVFMDLTGISTVDGLFRELKDLSAPVPVT-VHCENRDVVMKSMKELKDRSDPSAYALC 195
Query: 178 --PPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTR 235
P E+S + + L + + P+HICH+ST + L +++E +V+ +VTPHHL L
Sbjct: 196 KTSPRREVS-VAEVLALSIHHEHPVHICHLSTVKAL-QLVEPFREYVTSQVTPHHLLLDS 253
Query: 236 KDYEK-SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKERG----AAGLPG 290
+ + ++K PPLR R Y E LD + II +DHAPH +E+K +G G+P
Sbjct: 254 GAFRRFGTMVKTNPPLRPPESRIYP-EFLDRINIIGTDHAPHGIEEKRKGIWDAPPGIPN 312
Query: 291 LETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKG-WGEGKDADFAIVDMKKEWT 349
LE + LLL V++G + L + ++ P RIF +++KG EG DADF ++D+K+
Sbjct: 313 LEVVLKLLLTLVSKGRMSLSTIRRMLAEEPPRIFGLRSKGRIAEGMDADFTVIDLKETGR 372
Query: 350 IKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVKEGD 403
I+++EFY+KA +TP+EG+ G +G+ VM D EV+ + G I E D
Sbjct: 373 IRSDEFYSKAHYTPFEGFSYTG-ARHDHCQGQAVMRDGEVL-EGNGRYIPAEHD 424
>sp|Q91437|PYR1_SQUAC CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ] >gi|2118285|pir||A57541 pyrimidine
synthesis multifunctional protein CAD - spiny dogfish
>gi|951096|gb|AAA74569.1| (U18868) multifunctional
protein CAD [Squalus acanthias]
Length = 2242
Score = 209 bits (527), Expect = 4e-53
Identities = 136/357 (38%), Positives = 200/357 (55%), Gaps = 26/357 (7%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREF 107
I LPGLIDVHVHLR+ THKE +GT AA+ GG+T V MPNT P + D+ + + +
Sbjct: 1469 IRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGVTMVCAMPNTNPAITDQTSFALVQK 1528
Query: 108 LFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKAL--DITSVHA 165
L + D+AL FL A ++ AD + ++ G K + D L D S+
Sbjct: 1529 LATAGARCDFAL-FLGASSD--NADVLPLISNSAAG---LKMYLNDTFSTLKMDNVSLWM 1582
Query: 166 EDYELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIP-- 220
E +E K+P+ PIV E + L A+ ++P+HICHV+ +E ++ I A
Sbjct: 1583 EHFE---KWPKHLPIVVHAERQTVAAILMVAQLYQRPVHICHVARKEEIQIIRAAKQKGV 1639
Query: 221 WVSFEVTPHHLFLTRKDYEKSKLLK--VYPPLRDESDRRYLWEKLDNVPIIASDHAPHTL 278
V+ EV PHHLFL +D E K V P L + D LWE LD + A+DHAPH++
Sbjct: 1640 QVTCEVAPHHLFLNEEDLESIGHGKGQVRPMLSTKEDVNALWENLDVIDCFATDHAPHSV 1699
Query: 279 EDKERGA--AGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKD 336
E+K + G PGLET + LLL AV+ G L + D+V+++ NP +IF + ++
Sbjct: 1700 EEKNSDSPPPGYPGLETMLPLLLTAVSEGRLTIDDLVKRLYENPRKIFSL------PVQE 1753
Query: 337 ADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
+ VD+++EW I + +TK+ WTP+EG KV+G+V +LRGE+ D +V+ P
Sbjct: 1754 NTYVEVDLEQEWIIPSYMQFTKSKWTPFEGKKVKGRVRRVVLRGEVAYIDGQVLVPP 1810
>pir||QZDOP3 pyrimidine synthesis protein PYR1-3 - slime mold (Dictyostelium
discoideum) (fragments)
Length = 1481
Score = 205 bits (517), Expect = 6e-52
Identities = 141/388 (36%), Positives = 206/388 (52%), Gaps = 32/388 (8%)
Query: 22 VKDGKITKFSLRELKGDNKIKV----EKGKII-LPGLIDVHVHLRDFNETHKETIETGTK 76
+K K+ SL +KG I+ KII LPGL+DVHVHLR+ THKE ++GT
Sbjct: 695 IKCAKLFVDSLSYMKGPMPIENVDWRTSNKIIRLPGLVDVHVHLREPGATHKEDWDSGTA 754
Query: 77 AAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAG--NEPVKADFY 134
A+ GG T V MPNT P +MD+ + ++ + L K+ DY + F+ A N F
Sbjct: 755 TALAGGFTMVGAMPNTNPAIMDDASFELCKSLAASKARCDYGI-FIGATFTNTTTAGKFA 813
Query: 135 KIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPIVEISAIKKALNAAR 194
MG K + E+ L + + I +P PI + A + L A
Sbjct: 814 SDAMGM-------KMYLEETFAPLPLKDDINVWRDHIMNWPGTTPIC-VHADGRNLAAIL 865
Query: 195 KV----KKPLHICHVSTREGLKEILEANIPWV--SFEVTPHHLFLTRKDYEK--SKLLKV 246
+ K +H+CHVS +E + I +A + S EV+PHHL L KD + + +V
Sbjct: 866 LLGWMYDKHMHVCHVSHKEEIDIIRDAKKRGMKLSCEVSPHHLTLCDKDIPRIGAGQSEV 925
Query: 247 YPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK--ERGAAGLPGLETEVALLLDAVNR 304
P L E D LW+ +D + +IA+DHAPHT E+K + G PGLET + L+L AV+
Sbjct: 926 RPKLGTEEDLNALWDNIDYIDMIATDHAPHTWEEKCSAKPPPGFPGLETSLPLMLTAVHN 985
Query: 305 GMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPY 364
G + + D+V KM NP RIF + + + VDM++EWTI + Y++ GWTP+
Sbjct: 986 GRITIEDLVMKMHTNPIRIFNLPEQ------PDTYIEVDMEQEWTIPKKPLYSRCGWTPF 1039
Query: 365 EGWKVRGKVIMTILRGEIVMEDDEVIGK 392
EG +VRGKV+ +LRG+I D ++I +
Sbjct: 1040 EGLQVRGKVVKVVLRGQIAFIDGKIIAQ 1067
>sp|P20054|PYR1_DICDI PROTEIN PYR1-3 [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ]
Length = 2185
Score = 205 bits (517), Expect = 6e-52
Identities = 141/388 (36%), Positives = 206/388 (52%), Gaps = 32/388 (8%)
Query: 22 VKDGKITKFSLRELKGDNKIKV----EKGKII-LPGLIDVHVHLRDFNETHKETIETGTK 76
+K K+ SL +KG I+ KII LPGL+DVHVHLR+ THKE ++GT
Sbjct: 1399 IKCAKLFVDSLSYMKGPMPIENVDWRTSNKIIRLPGLVDVHVHLREPGATHKEDWDSGTA 1458
Query: 77 AAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAG--NEPVKADFY 134
A+ GG T V MPNT P +MD+ + ++ + L K+ DY + F+ A N F
Sbjct: 1459 TALAGGFTMVGAMPNTNPAIMDDASFELCKSLAASKARCDYGI-FIGATFTNTTTAGKFA 1517
Query: 135 KIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPIVEISAIKKALNAAR 194
MG K + E+ L + + I +P PI + A + L A
Sbjct: 1518 SDAMGM-------KMYLEETFAPLPLKDDINVWRDHIMNWPGTTPIC-VHADGRNLAAIL 1569
Query: 195 KV----KKPLHICHVSTREGLKEILEANIPWV--SFEVTPHHLFLTRKDYEK--SKLLKV 246
+ K +H+CHVS +E + I +A + S EV+PHHL L KD + + +V
Sbjct: 1570 LLGWMYDKHMHVCHVSHKEEIDIIRDAKKRGMKLSCEVSPHHLTLCDKDIPRIGAGQSEV 1629
Query: 247 YPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK--ERGAAGLPGLETEVALLLDAVNR 304
P L E D LW+ +D + +IA+DHAPHT E+K + G PGLET + L+L AV+
Sbjct: 1630 RPKLGTEEDLNALWDNIDYIDMIATDHAPHTWEEKCSAKPPPGFPGLETSLPLMLTAVHN 1689
Query: 305 GMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPY 364
G + + D+V KM NP RIF + + + VDM++EWTI + Y++ GWTP+
Sbjct: 1690 GRITIEDLVMKMHTNPIRIFNLPEQ------PDTYIEVDMEQEWTIPKKPLYSRCGWTPF 1743
Query: 365 EGWKVRGKVIMTILRGEIVMEDDEVIGK 392
EG +VRGKV+ +LRG+I D ++I +
Sbjct: 1744 EGLQVRGKVVKVVLRGQIAFIDGKIIAQ 1771
>emb|CAA32782.1| (X14634) PYR1-3B multifunctional enzyme (1014 AA) [Dictyostelium
discoideum]
Length = 1014
Score = 205 bits (517), Expect = 6e-52
Identities = 141/388 (36%), Positives = 206/388 (52%), Gaps = 32/388 (8%)
Query: 22 VKDGKITKFSLRELKGDNKIKV----EKGKII-LPGLIDVHVHLRDFNETHKETIETGTK 76
+K K+ SL +KG I+ KII LPGL+DVHVHLR+ THKE ++GT
Sbjct: 228 IKCAKLFVDSLSYMKGPMPIENVDWRTSNKIIRLPGLVDVHVHLREPGATHKEDWDSGTA 287
Query: 77 AAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAG--NEPVKADFY 134
A+ GG T V MPNT P +MD+ + ++ + L K+ DY + F+ A N F
Sbjct: 288 TALAGGFTMVGAMPNTNPAIMDDASFELCKSLAASKARCDYGI-FIGATFTNTTTAGKFA 346
Query: 135 KIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELISKYPERPPIVEISAIKKALNAAR 194
MG K + E+ L + + I +P PI + A + L A
Sbjct: 347 SDAMGM-------KMYLEETFAPLPLKDDINVWRDHIMNWPGTTPIC-VHADGRNLAAIL 398
Query: 195 KV----KKPLHICHVSTREGLKEILEANIPWV--SFEVTPHHLFLTRKDYEK--SKLLKV 246
+ K +H+CHVS +E + I +A + S EV+PHHL L KD + + +V
Sbjct: 399 LLGWMYDKHMHVCHVSHKEEIDIIRDAKKRGMKLSCEVSPHHLTLCDKDIPRIGAGQSEV 458
Query: 247 YPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK--ERGAAGLPGLETEVALLLDAVNR 304
P L E D LW+ +D + +IA+DHAPHT E+K + G PGLET + L+L AV+
Sbjct: 459 RPKLGTEEDLNALWDNIDYIDMIATDHAPHTWEEKCSAKPPPGFPGLETSLPLMLTAVHN 518
Query: 305 GMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPY 364
G + + D+V KM NP RIF + + + VDM++EWTI + Y++ GWTP+
Sbjct: 519 GRITIEDLVMKMHTNPIRIFNLPEQ------PDTYIEVDMEQEWTIPKKPLYSRCGWTPF 572
Query: 365 EGWKVRGKVIMTILRGEIVMEDDEVIGK 392
EG +VRGKV+ +LRG+I D ++I +
Sbjct: 573 EGLQVRGKVVKVVLRGQIAFIDGKIIAQ 600
>pir||T20371 hypothetical protein D2085.1 - Caenorhabditis elegans
>gi|3875382|emb|CAA91059.1| (Z54284) contains similarity
to Pfam domain: PF00117 (Glutamine amidotransferase
class-I), Score=244.1, E-value=6.1e-70, N=1; PF00185
(Aspartate/ornithine carbamoyltransferase), Score=397.5,
E-value=4.1e-116, N=1; PF00289 (Carbamoyl-phosphate
synthase >
Length = 2198
Score = 195 bits (491), Expect = 7e-49
Identities = 125/353 (35%), Positives = 188/353 (52%), Gaps = 23/353 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPG++D+HVH+R+ THKE T +KAA+ GG+TT+ MPNT P ++D + E L
Sbjct: 1476 LPGMVDIHVHVREPGATHKEDWATCSKAALAGGVTTILAMPNTSPVLVDTDSFYQTEQLA 1535
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
KS DYA L G P + F F + G K + + L + ++ ++ +
Sbjct: 1536 SAKSVVDYA---LYIGATPNNSKFAAEFADKAAG---LKMYLNETFSTLKMDNI-SDWAK 1588
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA-NIPW-VSF 224
+S +P PIV E + L A+ + +HI HV+T + + + EA W V+
Sbjct: 1589 HLSAFPANRPIVCHAEKQTLAAILCMAQMANRAVHIAHVATADEINLVKEAKQRGWNVTC 1648
Query: 225 EVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKE-- 282
EV PHHLFL +D + +V P L DR+ LW+ ++ + A+DHAPHT +K
Sbjct: 1649 EVCPHHLFLIEEDLPDG-IREVRPRLVKPEDRQALWDNMEYIDCFATDHAPHTWAEKTGK 1707
Query: 283 --RGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFA 340
+ G PG+E + LLL AV+ G L + ++ ++MS NP RIF + +D +
Sbjct: 1708 DGKIPPGFPGVEYMLPLLLTAVHDGKLTMKELTDRMSTNPRRIFNL------PPQDDTYI 1761
Query: 341 IVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD+ +EWTI +KAGWTP+ G KV GKV I+RGE + D ++ P
Sbjct: 1762 EVDLNEEWTIPENGGQSKAGWTPFAGRKVFGKVHNVIIRGEEAVIDGRIVAIP 1814
>pir||D82736 dihydroorotase XF0988 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9105922|gb|AAF83798.1|AE003937_2 (AE003937)
dihydroorotase [Xylella fastidiosa]
Length = 449
Score = 182 bits (457), Expect = 7e-45
Identities = 132/445 (29%), Positives = 220/445 (48%), Gaps = 53/445 (11%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEK-GKIILPGLIDVHVHLR 61
L++ + + GR D + +++G+I + I ++ G+ +LPG+ID VH R
Sbjct: 5 LIVNARLVNEGREFDSDLRIENGRIARIDTGLSAQSKDIVIDAAGRRLLPGMIDDQVHFR 64
Query: 62 DFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGF 121
+ THK I + + AAV GG+T+ DMPNT PP +D L+ + +++ +Y GF
Sbjct: 65 EPGLTHKGDIASESAAAVAGGLTSFMDMPNTNPPTLDVAALQAKYDAASGRAWGNY--GF 122
Query: 122 LLAGN----------EPVKADFYKIFMGASTGGIYSKN---FEEDYAKALDITSVHAEDY 168
L + +P + K+FMGASTG + N E + A H ED
Sbjct: 123 YLGASNDNLAAIQALDPKTSPGIKVFMGASTGNMLVDNEATLEGIFRDAPTPIITHCEDT 182
Query: 169 ELI----SKYPER----------PPIVEISAIKK----ALNAARKVKKPLHICHVSTREG 210
I +KY R P I A K A++ A+K LH+ H+ST +
Sbjct: 183 PTINATLAKYQSRYGDTLSAEQHPDIRSRQACLKSSQLAVSLAKKNGTRLHVLHISTADE 242
Query: 211 LKEILEA---------NIPWVSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLW 260
L+ + EA ++ E H L R DY + L+K P +++ SDR L
Sbjct: 243 LR-LFEAGPLVDAAGKRRKQITAETCIHFLHFDRMDYARLGNLIKCNPAIKEVSDREALI 301
Query: 261 EKL--DNVPIIASDHAPHTLEDKE----RGAAGLPGLETEVALLLDAVNRGMLELWDVVE 314
L D + ++A+DHAPHT E+K+ + +GLP ++ + L+ V+ G L + ++V
Sbjct: 302 AALAKDVIDVLATDHAPHTWEEKQQPYAQAPSGLPLVQYALVAALELVHAGRLSVTEIVR 361
Query: 315 KMSLNPARIFRIKNKGW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKV 373
K + PA++F + +G+ EG AD +V+ +T+K +E +K GW+P+EG R ++
Sbjct: 362 KFAHAPAQLFDVTGRGFLREGYWADLVLVE-DTPFTVKRQEILSKCGWSPFEGTTFRSRI 420
Query: 374 IMTILRGEIVMEDDEVIGKPRGERI 398
T + G V + + ++G P G+R+
Sbjct: 421 ASTWVNGHHVWDGNRLVGVPNGQRL 445
>gb|AAG20592.1| (AE005129) dihydroorotase; PyrC [Halobacterium sp. NRC-1]
Length = 422
Score = 178 bits (448), Expect = 8e-44
Identities = 129/411 (31%), Positives = 200/411 (48%), Gaps = 38/411 (9%)
Query: 10 LYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKE 69
L +GR+ D + DG+ L G+ + +LPG+ID HVH R HKE
Sbjct: 9 LADGRVRDIRL---DGERIDAVGTALDGELFVDANADYRVLPGMIDAHVHFRQPGFEHKE 65
Query: 70 TIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAGNEPV 129
T +G+++A GG+TTV D PNT PP + + + S D+ + + G
Sbjct: 66 TWASGSRSAAAGGVTTVVDQPNTAPPTVTGDAVDEKAAHAAADSVVDWGVNGGVTGEWDP 125
Query: 130 KADFYK-------IFMGASTG--GIYSKNFEEDYAKALD---ITSVHAEDYELISKYPE- 176
+ F + +F+ STG GI + F + +A + +VHAED + +
Sbjct: 126 ASLFDRSLFALGEVFLADSTGDMGIDAALFRDACQRAASEDVVVTVHAEDADRFDTAAKS 185
Query: 177 ----------RPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEV 226
R P E +A+++A+ + +HI H ST EG+ A + E
Sbjct: 186 RSDADAWSAYRTPEAEAAAVERAVEVGTEAGATIHIAHTSTPEGVD---AAAAGGATCEA 242
Query: 227 TPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKL--DNVPIIASDHAPHTLEDKER 283
TPHHLFL+R D + ++ PPLR + R L+E+L + ++A+DHAPHT +K
Sbjct: 243 TPHHLFLSRDDLDDLGTFGRMNPPLRSDPRREALFERLADGRIDVVATDHAPHTRAEKAA 302
Query: 284 ----GAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGW-GEGKDAD 338
+G+PG+ET + LLL A +RG L V + + NPA +F ++ KG G+DAD
Sbjct: 303 DIWDAPSGVPGVETALPLLLGAAHRGELSYERVRDVTAANPADVFGLERKGHIAAGRDAD 362
Query: 339 FAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
+VD I ++ ++ WTP+EG V MT++RG V + D V
Sbjct: 363 LVLVDPDDAREIHGDDLHSNCEWTPFEG-HVGVFPAMTLVRGTTVWDGDTV 412
>sp|P05990|PYR1_DROME CAD PROTEIN (RUDIMENTARY PROTEIN) [INCLUDES: GLUTAMINE-DEPENDENT
CARBAMOYL-PHOSPHATE SYNTHASE ; ASPARTATE
CARBAMOYLTRANSFERASE ; DIHYDROOROTASE ]
>gi|2144531|pir||QZFF rudimentary protein - fruit fly
(Drosophila melanogaster)
Length = 2236
Score = 176 bits (443), Expect = 3e-43
Identities = 119/342 (34%), Positives = 177/342 (50%), Gaps = 23/342 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPG IDVHVHLR + + + + +T V MPNT P ++D +T + L
Sbjct: 1482 LPGFIDVHVHLRSRSHAQGGLCQWNSSRS-GWRLTLVCAMPNTNPSIVDRETFTQFQELA 1540
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
K + DYAL + ++ A ++ A +Y N K D+TS
Sbjct: 1541 KAGARCDYAL--YVGASDDNWAQVNELASHACGLKMYL-NDTFGTLKLSDMTSWQRH--- 1594
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWV--SF 224
+S +P+R PIV E + + A + + +HICHV+ +E ++ I A V +
Sbjct: 1595 -LSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSAKEKGVKVNL 1653
Query: 225 EVTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK- 281
V PHHLFL+ KD + + +V P L D+ LWE +D + + A+DHAPHTL +K
Sbjct: 1654 RVCPHHLFLSTKDVDGLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKR 1713
Query: 282 -ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFA 340
ER G PG+ET + LLL AV+ G L + D+ K NP IF + ++ +
Sbjct: 1714 SERPPPGFPGVETILPLLLQAVHEGRLTMEDIKRKFHRNPKIIFNLPDQA------QTYV 1767
Query: 341 IVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEI 382
VD+ +EWTI E +K+GWTP+EG KV+G V ++LRGE+
Sbjct: 1768 EVDLDEEWTITGNEMKSKSGWTPFEGTKVKGLVYRSVLRGEL 1809
>emb|CAA28502.1| (X04813) CAD protein (AA 1 - 2236) [Drosophila melanogaster]
Length = 2236
Score = 176 bits (443), Expect = 3e-43
Identities = 119/342 (34%), Positives = 177/342 (50%), Gaps = 23/342 (6%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPG IDVHVHLR + + + + +T V MPNT P ++D +T + L
Sbjct: 1482 LPGFIDVHVHLRSRSHAQGGLCQWNSSRS-GWRLTLVCAMPNTNPSIVDRETFTQFQELA 1540
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
K + DYAL + ++ A ++ A +Y N K D+TS
Sbjct: 1541 KAGARCDYAL--YVGASDDNWAQVNELASHACGLKMYL-NDTFGTLKLSDMTSWQRH--- 1594
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWV--SF 224
+S +P+R PIV E + + A + + +HICHV+ +E ++ I A V +
Sbjct: 1595 -LSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSAKEKGVKVNL 1653
Query: 225 EVTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK- 281
V PHHLFL+ KD + + +V P L D+ LWE +D + + A+DHAPHTL +K
Sbjct: 1654 RVCPHHLFLSTKDVDGLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKR 1713
Query: 282 -ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFA 340
ER G PG+ET + LLL AV+ G L + D+ K NP IF + ++ +
Sbjct: 1714 SERPPPGFPGVETILPLLLQAVHEGRLTMEDIKRKFHRNPKIIFNLPDQA------QTYV 1767
Query: 341 IVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEI 382
VD+ +EWTI E +K+GWTP+EG KV+G V ++LRGE+
Sbjct: 1768 EVDLDEEWTITGNEMKSKSGWTPFEGTKVKGLVYRSVLRGEL 1809
>dbj|BAB06257.1| (AP001515) dihydroorotase [Bacillus halodurans]
Length = 428
Score = 172 bits (431), Expect = 7e-42
Identities = 137/418 (32%), Positives = 208/418 (48%), Gaps = 47/418 (11%)
Query: 13 GRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIE 72
G + + + DG I+ L + D + GK++ PGL+D+HVHLR+ KETIE
Sbjct: 15 GTVKTQDVLLHDGVISAIGLNLEETDAHVIEANGKLVTPGLVDLHVHLREPGGEAKETIE 74
Query: 73 TGTKAAVHGGITTVFDMPNTKP-----PVMDEKTLKMREF-LFKKKSYADYALGFLLAGN 126
TGTKAA GG TTV MPNT+P M T ++ E + + YA A+ G
Sbjct: 75 TGTKAAAKGGFTTVAAMPNTRPVPDSAEQMSWLTGRIDETGVVRVLPYA--AITTRQLGR 132
Query: 127 EPVKADFYKIF-----------MGASTGGIYSKNFEEDYAKALDITSV-HAEDYELISK- 173
E DF K+ +G + + + +E A L++ V H E+ LI
Sbjct: 133 E--LTDFAKLKEAGAFAFTDDGVGVQSAAMMLEAMKE--AAKLEMAIVAHCEENTLIQNG 188
Query: 174 ------YPERPPIVEISAIKKALNAARKVKKP------LHICHVSTREGLKEILEANIPW 221
+ ++ I I ++ ++++ AR V H+CH+ST+E ++ + +A
Sbjct: 189 SVHEGVFSKKHGIAGIPSVCESVHIARDVLLAEAAGVHYHVCHISTKESVRVVRDAKRAG 248
Query: 222 --VSFEVTPHHLFLTRKDYEKSKL-LKVYPPLRDESDRRYLWEKL--DNVPIIASDHAPH 276
V+ EVTPHHL L +D K+ PPLR + DR L E L + IA+DHAPH
Sbjct: 249 IRVTAEVTPHHLLLCDEDIPGLDAHYKMNPPLRGKEDREALIEGLLDGTIDFIATDHAPH 308
Query: 277 TLEDK----ERGAAGLPGLETEVALLLDA-VNRGMLELWDVVEKMSLNPARIFRIKNKGW 331
T E+K ER G+ GLET LL V +G L +V+ ++++PA F++
Sbjct: 309 TEEEKGQGMERAPFGIVGLETAFPLLYTHFVKKGTFTLKQLVDWLTIDPAETFQLPYGRL 368
Query: 332 GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
EG AD I+D++ E I F +K TP+ GW +G + T++ G++V E+ EV
Sbjct: 369 EEGAPADVTIIDLEAERAIDPAHFASKGRNTPFAGWTCQGWPVATLVGGKLVWEEKEV 426
>sp|P46538|PYRC_BACCL DIHYDROOROTASE (DHOASE) >gi|2118165|pir||I40167 dihydroorotase (EC
3.5.2.3) - Bacillus caldolyticus
>gi|312441|emb|CAA51737.1| (X73308) dihydroorotase
[Bacillus caldolyticus]
Length = 427
Score = 169 bits (425), Expect = 4e-41
Identities = 133/415 (32%), Positives = 205/415 (49%), Gaps = 40/415 (9%)
Query: 9 FLYNGRIIDGSIGVKDGKITKFSLRE-LKGDNKIKVEKGKIILPGLIDVHVHLRDFNETH 67
F +G ++ I ++ G I + L+ + + G++I+PGLID+HVHLR+
Sbjct: 11 FNKDGELMRTHIKIEHGTIAAILYEQPLEANEDVIDVGGRLIVPGLIDLHVHLREPGGEA 70
Query: 68 KETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKS------YADYALG- 120
KETIETGT AA GG TTV MPNT P ++ ++ + ++ + YA +G
Sbjct: 71 KETIETGTLAAAKGGFTTVAAMPNTNPAPDRKEQMEWLQARIRETARVNVLPYAAITIGQ 130
Query: 121 ------FLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSV-HAEDYELIS- 172
A E F +G + G+ + ++ A ALD+ V H ED L +
Sbjct: 131 KGEELTDFAALKEAGAFAFTDDGVGVQSAGMMFEAMKQ--AAALDMAIVAHCEDDTLTNG 188
Query: 173 ------KYPERPPIVEISAIKKALNAARKVKKP------LHICHVSTREGLKEILEANIP 220
++ R + I ++ +A++ AR V H+CH+ST+E ++ + +A
Sbjct: 189 GAVHDGEFARRYGLRGIPSVCEAVHIARDVLLAEAAGCHYHVCHISTKESVRVVRDAKRA 248
Query: 221 W--VSFEVTPHHLFLTRKDYE-KSKLLKVYPPLRDESDRRYLWEKL--DNVPIIASDHAP 275
V+ EVTPHHL L +D K+ PPLR DR L E L + IA+DHAP
Sbjct: 249 GIRVTAEVTPHHLLLCDEDIPGLDANYKMNPPLRSREDRDALIEGLLDGTIDFIATDHAP 308
Query: 276 HTLEDKERGAA----GLPGLETEVALL-LDAVNRGMLELWDVVEKMSLNPARIFRIKNKG 330
HT +K +G G+ GLET LL V G+ L +V+ +++ PA+ F +K
Sbjct: 309 HTAAEKAKGIEAAPFGIVGLETAFPLLYTHFVKTGVFTLKQLVDWLTIKPAQCFGLKAGR 368
Query: 331 WGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVME 385
G AD A++D++ E I E F +K TP+ GW +G +MT + G +V E
Sbjct: 369 LAVGAPADIAVIDLETEEAIDPETFASKGKNTPFAGWVCQGWPVMTFVGGTLVWE 423
>sp|O66990|PYRC_AQUAE DIHYDROOROTASE (DHOASE) >gi|7435951|pir||C70370 dihydroorotase -
Aquifex aeolicus >gi|2983361|gb|AAC06948.1| (AE000708)
dihydroorotase [Aquifex aeolicus]
Length = 422
Score = 168 bits (422), Expect = 8e-41
Identities = 138/417 (33%), Positives = 202/417 (48%), Gaps = 44/417 (10%)
Query: 12 NGRIIDGS--------IGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDF 63
NG +ID S I V++GKI K L + +I KG I+ PG ID+HVHLRD
Sbjct: 8 NGYVIDPSQNLEGEFDILVENGKIKKIDKNILVPEAEIIDAKGLIVCPGFIDIHVHLRDP 67
Query: 64 NETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYA---DYALG 120
+T+KE IE+G++ AV GG TT+ MPNT PP+ + T + L K KS G
Sbjct: 68 GQTYKEDIESGSRCAVAGGFTTIVCMPNTNPPI--DNTTVVNYILQKSKSVGLCRVLPTG 125
Query: 121 FLLAGNEPVK-ADFYKIFMGASTGGIYSKNFEEDYA---KALDITSV-------HAED-- 167
+ G + + ADFY + + D + KAL++ S H ED
Sbjct: 126 TITKGRKGKEIADFYSLKEAGCVAFTDDGSPVMDSSVMRKALELASQLGVPIMDHCEDDK 185
Query: 168 --YELISK--------YPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLK--EIL 215
Y +I++ R P E I + A++ +HI HVST+ L+ E
Sbjct: 186 LAYGVINEGEVSALLGLSSRAPEAEEIQIARDGILAQRTGGHVHIQHVSTKLSLEIIEFF 245
Query: 216 EANIPWVSFEVTPHHLFLTRKDYEKSKL-LKVYPPLRDESDRRYLWE--KLDNVPIIASD 272
+ ++ EV P+HL T ++ S +V PPLR + DR L E K + A+D
Sbjct: 246 KEKGVKITCEVNPNHLLFTEREVLNSGANARVNPPLRKKEDRLALIEGVKRGIIDCFATD 305
Query: 273 HAPHTLEDKER---GAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNK 329
HAPH +KE G+ GL+T + L+ +G++ L ++E ++NPARI +
Sbjct: 306 HAPHQTFEKELVEFAMPGIIGLQTALPSALELYRKGIISLKKLIEMFTINPARIIGVDLG 365
Query: 330 GWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMED 386
G AD I D KEW + E +K+ TP G ++GKVI TI G++V +D
Sbjct: 366 TLKLGSPADITIFDPNKEWILNEETNLSKSRNTPLWGKVLKGKVIYTIKDGKMVYKD 422
>dbj|BAA94294.1| (AB029444) Dihydroorotase [Leishmania mexicana amazonensis]
Length = 404
Score = 166 bits (416), Expect = 4e-40
Identities = 121/396 (30%), Positives = 181/396 (45%), Gaps = 78/396 (19%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LP LID HVH R+ HK + + + AA +GGI DMPNT PP L +
Sbjct: 14 LPPLIDCHVHFREPGLEHKADMASESTAAYYGGIAVACDMPNTSPPTQSIAALADKVARA 73
Query: 110 KKKSYADYALGFLLAG-------------NEPVKADF------YKIFMGASTGGIYS--- 147
K ++A+ L F P A+ K+++ STG + S
Sbjct: 74 KATAHAECKLFFFFGATAEAHLQELEELWTNPAHAELKTHCCGLKLYLDNSTGNMKSSHS 133
Query: 148 ---KNFEEDYAKALDITSVHAEDYEL----ISKYP---------ERPPIVEISAIKKALN 191
K+FE Y + + H E E+ +++P RP E+++++ A+
Sbjct: 134 VVVKSFEM-YGRLQIVLVAHCEQSEINDAAAAQHPYDGPASHSLRRPADSEVASVQSAIA 192
Query: 192 AARKVKKPLHICHVSTREGLKEILEANIP----WVSFEVTPHHLFLTRKDYE-KSKLLKV 246
AR+ + PLH+ HVS + L + EA ++ EV+PHHLFLT DY +KV
Sbjct: 193 LARQYRTPLHLAHVSAAQSLDVVREARAADPTLQLTCEVSPHHLFLTTSDYSCCGARVKV 252
Query: 247 YPPLRDESDRRYLWEKL--DNVPIIASDHAPHTLEDKE------RGAAGLPGLETEVALL 298
PP+R LW L V I +DHAPHT+ +K+ + +G+P +E V LL
Sbjct: 253 NPPVRPPQHHEALWAGLLDGTVDCIGTDHAPHTIAEKDHCDAAAQPPSGMPAIEVVVPLL 312
Query: 299 LDAV-------------------NRGM-LELWDVVEKMSLNPARIFRIKNKGWGEGKDAD 338
L V +G + L D+V + NP RIF ++ DA
Sbjct: 313 LTVVAGQWPHPTGAKPSTLAAAEQQGRHVTLDDIVRVLHTNPNRIFNLQQ------TDAP 366
Query: 339 FAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVI 374
D+ EWT++ EE ++K WTPYEGW++RG+ +
Sbjct: 367 HRSFDLACEWTVRGEELHSKCQWTPYEGWRLRGRAM 402
>dbj|BAB06028.1| (AP001515) allantoinase [Bacillus halodurans]
Length = 438
Score = 163 bits (409), Expect = 3e-39
Identities = 120/387 (31%), Positives = 194/387 (50%), Gaps = 47/387 (12%)
Query: 46 GKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMP-NTKPPVMDEKTLKM 104
G + PG++DVHVH + T E +G+K+ GG+TT FDMP N+ PP + + L
Sbjct: 52 GLHLFPGMVDVHVHFNEPGRTEWEGFASGSKSLAAGGVTTYFDMPLNSNPPTITREELDK 111
Query: 105 REFLFKKKSYADYAL-GFLLAGNEPVKADF-------YKIFMGASTGGIYSKNFEEDYAK 156
+ L +KS DY G L+ GN D +K FM + + +E K
Sbjct: 112 KRQLANEKSLVDYRFWGGLVPGNIDHLQDLHDGGVIGFKAFMSECGTDDFQFSHDETLLK 171
Query: 157 AL-------DITSVHAEDYELIS---------------KYPERPPIV-EISAIKKALNAA 193
+ I +VHAE E+++ Y E PIV E+ A+++ L A
Sbjct: 172 GMKKIAALGSILAVHAESNEMVNALTTIAIEEQRLTVKDYSEARPIVSELEAVERILRFA 231
Query: 194 RKVKKPLHICHVSTREGLKEILEANIPW--VSFEVTPHHLFLTRKDY-EKSKLLKVYPPL 250
+ P+HICHVS+R+ LK I +A VS E PH+L + ++ E L K PPL
Sbjct: 232 QLTCCPIHICHVSSRKVLKRIKQAKGEGVNVSVETCPHYLLFSLDEFAEIGYLAKCAPPL 291
Query: 251 RDESDRRYLWEKL--DNVPIIASDHAPHTLEDKERGA------AGLPGLETEVALLL-DA 301
R+ + LW+ L + +I+SDH+P +L + G G+ G + +A++L +
Sbjct: 292 RERQEVEDLWDGLMAGEIDLISSDHSP-SLPQMKTGKTIFEVWGGIAGCQNTLAVMLTEG 350
Query: 302 VNRGMLELWDVVEKMSLNPARIFRI-KNKGWGE-GKDADFAIVDMKKEWTIKAEEFYTKA 359
++ + L +V+ +S PA+ F + KG + G +A F ++D+ + +T+ A + Y +
Sbjct: 351 YHKRKMPLTQIVQLLSTEPAKRFGLYPQKGTIQVGAEASFTLIDLNESYTLNASDLYYRH 410
Query: 360 GWTPYEGWKVRGKVIMTILRGEIVMED 386
+PY G + RGKV TI +G+ V +D
Sbjct: 411 PISPYVGQRFRGKVKHTICQGKHVYQD 437
>gb|AAF68548.1|AF252765_1 (AF252765) rudimentary [Drosophila simulans]
Length = 399
Score = 161 bits (403), Expect = 1e-38
Identities = 91/232 (39%), Positives = 134/232 (57%), Gaps = 15/232 (6%)
Query: 171 ISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSF--E 225
+S +P+R PIV E + + A + + +HICHV+ +E ++ I A V E
Sbjct: 37 LSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRAAKEKGVKVTCE 96
Query: 226 VTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK-- 281
V PHHLFL+ KD E+ + +V P L D+ LWE +D + + A+DHAPHTL +K
Sbjct: 97 VCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKRS 156
Query: 282 ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAI 341
ER G PG+ET + LLL AV+ G L L D+ K NP IF + ++ +
Sbjct: 157 ERPPPGFPGVETILPLLLQAVHEGRLTLEDIKRKFHRNPKIIFNLPDQA------QTYVE 210
Query: 342 VDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD+ +EWTI +E +K+GWTP+EG KV+G+V +LRGE+ D +V+ +P
Sbjct: 211 VDLDEEWTITGKEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVLVQP 262
>gb|AAF68549.1|AF252766_1 (AF252766) rudimentary [Drosophila simulans]
>gi|7716800|gb|AAF68550.1|AF252767_1 (AF252767)
rudimentary [Drosophila simulans]
>gi|7716802|gb|AAF68551.1|AF252768_1 (AF252768)
rudimentary [Drosophila simulans]
>gi|7716804|gb|AAF68552.1|AF252769_1 (AF252769)
rudimentary [Drosophila simulans]
>gi|7716806|gb|AAF68553.1|AF252770_1 (AF252770)
rudimentary [Drosophila simulans]
Length = 399
Score = 161 bits (403), Expect = 1e-38
Identities = 91/232 (39%), Positives = 134/232 (57%), Gaps = 15/232 (6%)
Query: 171 ISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPWVSF--E 225
+S +P+R PIV E + + A + + +HICHV+ +E ++ I A V E
Sbjct: 37 LSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRAAKEKGVKVTCE 96
Query: 226 VTPHHLFLTRKDYEK--SKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDK-- 281
V PHHLFL+ KD E+ + +V P L D+ LWE +D + + A+DHAPHTL +K
Sbjct: 97 VCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKRS 156
Query: 282 ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAI 341
ER G PG+ET + LLL AV+ G L L D+ K NP IF + ++ +
Sbjct: 157 ERPPPGFPGVETILPLLLQAVHEGRLTLEDIKRKFHRNPKIIFNLPDQA------QTYVE 210
Query: 342 VDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKP 393
VD+ +EWTI +E +K+GWTP+EG KV+G+V +LRGE+ D +V+ +P
Sbjct: 211 VDLDEEWTITGKEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVLVQP 262
>gb|AAG02130.1|AF146701_6 (AF146701) L-hydantoinase HyuH [Arthrobacter aurescens]
Length = 458
Score = 158 bits (395), Expect = 1e-37
Identities = 136/430 (31%), Positives = 212/430 (48%), Gaps = 60/430 (13%)
Query: 15 IIDGSIGVKDGKITKFSL--RELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKE-TI 71
I + I VKDGK+ S R+++ I GK ++PG++D HVH+ D + ++
Sbjct: 17 ITEADILVKDGKVAAISADTRDVEASRTIDAG-GKFVMPGVVDEHVHIIDMDLKNRYGRF 75
Query: 72 ETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYA-----DYAL-GFLLAG 125
E +++A GGITT+ +MP T PP T + FL KKK D+AL G + G
Sbjct: 76 ELDSESAAVGGITTIIEMPITFPP-----TTTLDAFLEKKKQAGQRLKVDFALYGGGVPG 130
Query: 126 NEP-------VKADFYKIFMGASTGGIYS-----KNFE--EDYAKALDITSVHAEDYELI 171
N P A +K M AS G++ + FE ++ A + VHAE+ +I
Sbjct: 131 NLPEIRKMHDAGAVGFKSMMAASVPGMFDAVSDGELFEIFQEIAACGSVIVVHAENETII 190
Query: 172 SKYPER----------------PPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEIL 215
++ P E AI++AL ++ L + HVS +G++ I
Sbjct: 191 QALQKQIKAAGGKDMAAYEASQPVFQENEAIQRALLLQKEAGCRLIVLHVSNPDGVELIH 250
Query: 216 EANIPW--VSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKLDN--VPIIA 270
+A V E P +L +T D E+ +KV PP+R LWE+L+N + +
Sbjct: 251 QAQSEGQDVHCESGPQYLNITTDDAERIGPYMKVAPPVRSAEMNVRLWEQLENGVIDTLG 310
Query: 271 SDHAPHTLEDKERG-------AAGLPGLETEVALLL-DAVNRGMLELWDVVEKMSLNPAR 322
SDH H +EDKE G G GLET + ++L + VN+G L L +VE M PA+
Sbjct: 311 SDHGGHPVEDKEPGWKDVWKAGNGALGLETSLPMMLTNGVNKGRLSLERLVEVMCEKPAK 370
Query: 323 IFRI-KNKGWGE-GKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRG 380
+F I KG + G DAD I+D+ + + A +F + ++P++G V G ++T++RG
Sbjct: 371 LFGIYPQKGTLQVGSDADLLILDLDIDTKVDASQFRSLHKYSPFDGMPVTGAPVLTMVRG 430
Query: 381 EIVMEDDEVI 390
+V E EV+
Sbjct: 431 TVVAEQGEVL 440
>sp|P77884|PYRC_LACPL DIHYDROOROTASE (DHOASE) >gi|1514601|emb|CAA91003.1| (Z54240)
dihydroorotase, carbamoylaspartic dehydrase
[Lactobacillus plantarum]
Length = 430
Score = 156 bits (391), Expect = 4e-37
Identities = 128/376 (34%), Positives = 175/376 (46%), Gaps = 48/376 (12%)
Query: 49 ILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKP-PVMDEKTLKM--- 104
+ PG +DVHVHLRD +T KETI TGT AA HGG TTV MPN P P E+ M
Sbjct: 53 VSPGFVDVHVHLRDPGQTAKETIATGTLAAAHGGFTTVGAMPNVDPVPDTPERVATMVAR 112
Query: 105 --REFLFKKKSYA------------DYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNF 150
+E YA D+A G AG V D G T G
Sbjct: 113 NQQEAHVHVAQYASITTGRTSEQLVDFA-GIKAAGAFAVSNDG----SGVQTAGTMFAAM 167
Query: 151 EEDYAKALDITSVHAEDYELI-------SKYPERPPIVEISAIKKALNAARKVKKP---- 199
+ L + + H ED L +R + I+ + +A AR V
Sbjct: 168 QGAAKVGLPLAA-HVEDDSLYHHGVMNAGPVADRLGLPGINNVSEAAQVARDVMLAEASG 226
Query: 200 --LHICHVSTREGLKEILEANIPWVSF--EVTPHHLFLTRKDYEKSK-LLKVYPPLRDES 254
H+CHVST E L+ I A ++ EV+PHHL L +D +LK+ PPLR
Sbjct: 227 VHYHVCHVSTAESLRVIRNAKAAGINVTCEVSPHHLLLCDEDITMDNPMLKMNPPLRSAK 286
Query: 255 DRRYLWEKL--DNVPIIASDHAPHTLEDKE----RGAAGLPGLETEVALLLDA-VNRGML 307
DR L L + +IA+DHAPHT +K+ A G+ G+ET A L A V +L
Sbjct: 287 DRAALVAGLLDGTIDMIATDHAPHTDAEKQGSMKTAAFGITGIETAFATLYTALVKTRLL 346
Query: 308 ELWDVVEKMSLNPARIFRIKNKG-WGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEG 366
L ++E MS P +F + G G AD I+D+ ++ I+A +K +P+ G
Sbjct: 347 TLGRLIELMSTRPTELFGLNTAGRLVVGAPADLTIIDLDHQYEIEAATMLSKGHNSPFIG 406
Query: 367 WKVRGKVIMTILRGEI 382
W V G V+MT++ G++
Sbjct: 407 WPVYGNVLMTLVDGKL 422
>sp|P81006|HYDA_ARTAU D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPASE)
Length = 458
Score = 155 bits (389), Expect = 6e-37
Identities = 134/429 (31%), Positives = 210/429 (48%), Gaps = 58/429 (13%)
Query: 15 IIDGSIGVKDGKITKFSLRELKGDNKIKVEKG-KIILPGLIDVHVHLRDFNETHKE-TIE 72
I + I VKDGK+ S + ++ G K ++PG++D HVH+ D + ++ E
Sbjct: 17 ITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHVHIIDMDLKNRYGRFE 76
Query: 73 TGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYA-----DYAL-GFLLAGN 126
+++A GGITT+ +MP T PP T + FL KKK D+AL G + GN
Sbjct: 77 LDSESAAVGGITTIIEMPITFPP-----TTTLDAFLEKKKQAGQRLKVDFALYGGGVPGN 131
Query: 127 EP-------VKADFYKIFMGASTGGIYS-----KNFE--EDYAKALDITSVHAEDYELIS 172
P A +K M AS G++ + FE ++ A + VHAE+ +I
Sbjct: 132 LPEIRKMHDAGAVGFKSMMAASVPGMFDAVSDGELFEIFQEIAACGSVIVVHAENETIIQ 191
Query: 173 KYPER----------------PPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILE 216
++ P E AI++AL ++ L + HVS +G++ I +
Sbjct: 192 ALQKQIKAAGGKDMAAYEASQPVFQENEAIQRALLLQKEAGCRLIVLHVSNPDGVELIHQ 251
Query: 217 ANIPW--VSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKLDN--VPIIAS 271
A V E P +L +T D E+ +KV PP+R LWE+L+N + + S
Sbjct: 252 AQSEGQDVHCESGPQYLNITTDDAERIGPYMKVAPPVRSAEMNIRLWEQLENGLIDTLGS 311
Query: 272 DHAPHTLEDKERG-------AAGLPGLETEVALLL-DAVNRGMLELWDVVEKMSLNPARI 323
DH H +EDKE G G GLET + ++L + VN+G L L +VE M PA++
Sbjct: 312 DHGGHPVEDKEPGWKDVWKAGNGALGLETSLPMMLTNGVNKGRLSLERLVEVMCEKPAKL 371
Query: 324 FRI-KNKGWGE-GKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGE 381
F I KG + G DAD I+D+ + + A +F + ++P++G V G ++T++RG
Sbjct: 372 FGIYPQKGTLQVGSDADLLILDLDIDTKVDASQFRSLHKYSPFDGMPVTGAPVLTMVRGT 431
Query: 382 IVMEDDEVI 390
+V E EV+
Sbjct: 432 VVAEKGEVL 440
>emb|CAB93366.1| (AL357523) dihydroorotase [Streptomyces coelicolor A3(2)]
Length = 428
Score = 154 bits (385), Expect = 2e-36
Identities = 125/406 (30%), Positives = 197/406 (47%), Gaps = 40/406 (9%)
Query: 24 DGKITKFSLRELKGDNKIKVEK-GKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGG 82
DG + + L + VE GK++LPGL+D+H HLR+ ET+ TGT+AA GG
Sbjct: 22 DGTVVEAVGTNLSAEGAEVVEADGKVLLPGLVDLHTHLREPGREDSETVLTGTRAAASGG 81
Query: 83 ITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYAD-YALGFLLAGNEPVK-ADFYKIFMGA 140
T VF M NT P ++ L ++ Y D +G + G E K A+ + A
Sbjct: 82 YTNVFAMANTFPVADTAGVVEQVWRLGQESGYCDVQPIGAVTVGLEGAKLAELGAMHESA 141
Query: 141 STGGIYSKNFE-----------EDYAKALD-ITSVHAEDYELISKYPER----------- 177
+ ++S + + +Y KA + + + HA++ L
Sbjct: 142 AGVTVFSDDGKCVHDAVIMRRALEYVKAFNGVVAQHAQEPRLTEGAQMNEGVVSAELGLG 201
Query: 178 --PPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPW--VSFEVTPHHLFL 233
P + E S I + + A V +HICH+ST ++ + A V+ EVTPHHL L
Sbjct: 202 GWPAVAEESVIARDVLLAEHVGSRVHICHLSTAGSVEIVRWAKSRGIDVTAEVTPHHLLL 261
Query: 234 TRKDYEK-SKLLKVYPPLRDESDRRYLWEKL--DNVPIIASDHAPHTLEDKE----RGAA 286
T + + + KV PPLR E D L E L + I+A+DHAPH EDK+ A
Sbjct: 262 TDELVRSYNPVYKVNPPLRTERDVMALREALADGTIDIVATDHAPHPHEDKDCEWAAAAM 321
Query: 287 GLPGLETEVALLLDA-VNRGMLELWDVVEKMSLNPARIFRIKNKG--WGEGKDADFAIVD 343
G+ GLET ++++ + V+ G+L+ V ++MS PA+I + G G+ A+ +VD
Sbjct: 322 GMVGLETALSVVQETMVDTGLLDWAGVADRMSFKPAKIGQATGHGRPVSAGEPANLTLVD 381
Query: 344 MKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
+ F +++ TPYEG ++ G+V T LRG+ + D ++
Sbjct: 382 AAYRGQVDPAGFASRSRNTPYEGRELPGRVTHTWLRGKATLVDGKL 427
>sp|P77671|ALN_ECOLI ALLANTOINASE >gi|7428266|pir||G64782 probable allantoinase (EC
3.5.2.5) - Escherichia coli >gi|1773192|gb|AAB40264.1|
(U82664) similar to S. cerevisiae dal1 [Escherichia
coli] >gi|1786722|gb|AAC73614.1| (AE000157) putative
hydrolase [Escherichia coli K12]
>gi|2735238|gb|AAB93853.1| (U89279) GlxB3 [Escherichia
coli]
Length = 453
Score = 153 bits (383), Expect = 3e-36
Identities = 126/440 (28%), Positives = 212/440 (47%), Gaps = 61/440 (13%)
Query: 14 RIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIET 73
R++D I VK GKI ++L ++ G ++ PG++D H H+ + +H E ET
Sbjct: 19 RVVD--IAVKGGKIAAIG-QDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYET 75
Query: 74 GTKAAVHGGITTVFDMP-NTKPPVMDEKTLKMREFLFKKKSYADYA-LGFLLA------- 124
GT+AA GGITT+ +MP N P +D +++++ K K D A LG L++
Sbjct: 76 GTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLH 135
Query: 125 -----------------GNEPVKADF-----YKIFMGASTGG-------IYSKNF---EE 152
G+ + DF ++ F GA G ++ +N +E
Sbjct: 136 ELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALICDE 195
Query: 153 DYAKALDITSVHAEDYELISKYPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLK 212
+A V A DY RP E+ AI++ L A+ LH+CHVS+ EG++
Sbjct: 196 LGEEAKREGRVTAHDY-----VASRPVFTEVEAIRRVLYLAKVAGCRLHVCHVSSPEGVE 250
Query: 213 EILEANIPW--VSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKLDN--VP 267
E+ A V+ E PH+ L +E+ L K PP+RD +++ +WEKL N +
Sbjct: 251 EVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEID 310
Query: 268 IIASDHAPHTLEDKE----RGAAGLPGLETEVALLLD-AVNRGMLELWDVVEKMSLNPAR 322
+ SDH+P E K + G+ GL++ + ++ D AV + + L + M+ N A
Sbjct: 311 CLVSDHSPCPPEMKAGNIMKAWGGIAGLQSCMDVMFDEAVQKRGMSLPMFGKLMATNAAD 370
Query: 323 IFRIKNKG-WGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGE 381
IF ++ KG GKDADF + + + ++ + +PY G + ++ TILRG+
Sbjct: 371 IFGLQQKGRIAPGKDADFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGARITKTILRGD 430
Query: 382 IVMEDDEVIG-KPRGERIVK 400
++ + ++ P+G+ I+K
Sbjct: 431 VIYDIEQGFPVAPKGQFILK 450
>sp|Q9UX05|PYRC_SULSO DIHYDROOROTASE (DHOASE) >gi|6015862|emb|CAB57689.1| (Y18930)
dihydroorotase [Sulfolobus solfataricus]
Length = 390
Score = 153 bits (382), Expect = 4e-36
Identities = 118/371 (31%), Positives = 188/371 (49%), Gaps = 33/371 (8%)
Query: 32 LRELKGDNK--IKVEKGKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDM 89
++E+K K I + KG +ILPG ID+H H+R +KE + +GT A +GGIT + DM
Sbjct: 27 IKEIKSICKPDIALPKGTLILPGAIDLHTHIRGLKLAYKEDVVSGTSEASYGGITLIGDM 86
Query: 90 PNTKPPV--MDEKTLKMREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYS 147
PN+ P V M+ T K+REF + S DY F+ +G V D K+ G
Sbjct: 87 PNSVPFVNTMETITAKLREFEY--YSRVDY---FVYSG---VTKDLKKVDKFPIAG---Y 135
Query: 148 KNFEEDYAKALDITSVHAEDYELISKYPERPPIVEISAIKKALN-----AARKVKKPLHI 202
K F ED K + + + +++ +PE P + + K LN A K
Sbjct: 136 KIFPEDLEKEETLEVLKSMKLKIL--HPEVPLALRGNR-KLRLNIWYEIGALYYVKGYQN 192
Query: 203 CHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEK 262
H++ ++ + A + ++TPHHL + D EK L KV PP+RD ++R +L +
Sbjct: 193 VHITHATNIRTVRLAKELGFTVDITPHHLLV---DREKECLTKVNPPIRDTNERLWLLQA 249
Query: 263 LDNVPIIASDHAPHTLEDKERG----AAGLPGLETEVALLLDAVNRGMLELWDVVEKMSL 318
++ V + SDHAPH +K++ G+ L V +L V++G++ + VE +S
Sbjct: 250 INEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISIDRAVELIST 309
Query: 319 NPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTIL 378
NPARI I E A+F I+ K+W + Y+K TP +G+ +R + MTI+
Sbjct: 310 NPARILNIPYGEIKENNYANFTIIQF-KDWRYSTK--YSKVIETPLDGFPLRASIYMTII 366
Query: 379 RGEIVMEDDEV 389
+G++ + EV
Sbjct: 367 QGKVGSLEGEV 377
>gb|AAK40922.1| Dihydroorotase (carbamoylaspartic dehydrase) (DHOase) (pyrC)
[Sulfolobus solfataricus]
Length = 390
Score = 153 bits (382), Expect = 4e-36
Identities = 118/371 (31%), Positives = 188/371 (49%), Gaps = 33/371 (8%)
Query: 32 LRELKGDNK--IKVEKGKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDM 89
++E+K K I + KG +ILPG ID+H H+R +KE + +GT A +GGIT + DM
Sbjct: 27 IKEIKSICKPDIALPKGTLILPGAIDLHTHIRGLKLAYKEDVVSGTSEASYGGITLIGDM 86
Query: 90 PNTKPPV--MDEKTLKMREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYS 147
PN+ P V M+ T K+REF + S DY F+ +G V D K+ G
Sbjct: 87 PNSVPFVNTMETITAKLREFEY--YSRVDY---FVYSG---VTKDLKKVDKFPIAG---Y 135
Query: 148 KNFEEDYAKALDITSVHAEDYELISKYPERPPIVEISAIKKALN-----AARKVKKPLHI 202
K F ED K + + + +++ +PE P + + K LN A K
Sbjct: 136 KIFPEDLEKEETLEVLKSMKLKIL--HPEVPLALRGNR-KLRLNIWYEIGALYYVKGYQN 192
Query: 203 CHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEK 262
H++ ++ + A + ++TPHHL + D EK L KV PP+RD ++R +L +
Sbjct: 193 VHITHATNIRTVRLAKELGFTVDITPHHLLV---DREKECLTKVNPPIRDTNERLWLLQA 249
Query: 263 LDNVPIIASDHAPHTLEDKERG----AAGLPGLETEVALLLDAVNRGMLELWDVVEKMSL 318
++ V + SDHAPH +K++ G+ L V +L V++G++ + VE +S
Sbjct: 250 INEVDTVVSDHAPHASFEKQQPYEICPPGIAALSFTVPFILTLVSKGIISIDRAVELIST 309
Query: 319 NPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTIL 378
NPARI I E A+F I+ K+W + Y+K TP +G+ +R + MTI+
Sbjct: 310 NPARILNIPYGEIKENNYANFTIIQF-KDWRYSTK--YSKVIETPLDGFPLRASIYMTII 366
Query: 379 RGEIVMEDDEV 389
+G++ + EV
Sbjct: 367 QGKVGSLEGEV 377
>sp|Q9RV76|ALN_DEIRA PROBABLE ALLANTOINASE >gi|7473401|pir||E75429 probable allantoinase
- Deinococcus radiodurans (strain R1)
>gi|6458893|gb|AAF10727.1|AE001965_1 (AE001965)
allantoinase, putative [Deinococcus radiodurans]
Length = 448
Score = 150 bits (374), Expect = 4e-35
Identities = 119/397 (29%), Positives = 187/397 (46%), Gaps = 52/397 (13%)
Query: 46 GKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMP-NTKPPVMDEKTLKM 104
G + PG++D HVHL + TH E ETGT+A GG T+ DMP N+ PPV+ + +
Sbjct: 49 GLHVFPGVLDDHVHLNEPGRTHWEGFETGTQALAAGGATSFLDMPLNSSPPVLTRERFED 108
Query: 105 REFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGI---YSKNFEEDYAKALDIT 161
+ L ++KS D+ L G P+ D G+ S + +++ A D+T
Sbjct: 109 KARLGEEKSLIDFG---LWGGLTPLNLDQLDDLAECGVIGLKAFMSHSGLDEFPAADDLT 165
Query: 162 ---------------SVHAEDYELISKYPE----------------RPPIVEISAIKKAL 190
+ HAE E + E RP + E+ A+++AL
Sbjct: 166 LYEGMRTAKRHGLVVATHAESNEFTRRLTETARAQGKSGVRDYLESRPVVTELEAVQRAL 225
Query: 191 NAARKVKKPLHICHVSTREGLKEILEANIPW--VSFEVTPHHLFLTRKDYEK-SKLLKVY 247
A+ LH+ HVS+ + E V+ E PH+L T +D E+ LK
Sbjct: 226 LFAQDTGAALHLVHVSSGAAVALAYEGKQKGIDVTIETCPHYLHFTGEDVERVGAALKCA 285
Query: 248 PPLRDESDRRYLWEKL--DNVPIIASDHAP-----HTLEDKERGAAGLPGLETEVALLL- 299
PPLRD + + LW +L ++ + SDH+P T ED G+ G ++ + ++L
Sbjct: 286 PPLRDPAVQEELWRELLAGHIDTVGSDHSPAPPDMKTSEDFFSLWGGISGAQSTLNVMLE 345
Query: 300 DAVNRGMLELWDVVEKMSLNPARIFRIKNKG-WGEGKDADFAIVDMKKEWTIKAEEFYTK 358
D + L L + ++LNPA+ F + KG G DADFA+V + +++T+ + Y +
Sbjct: 346 DGYAQRGLPLEIIAALLALNPAQRFGLPQKGRLAVGADADFALVALGEKFTL--DTLYDR 403
Query: 359 AGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRG 395
PY G +G+V T LRG+ V ++ E G PRG
Sbjct: 404 WQQNPYRGQSFQGRVHATYLRGQPVYQNGEFTGTPRG 440
>pir||T30519 dihydroorotase (EC 3.5.2.3) - Trypanosoma cruzi
>gi|5421740|dbj|BAA31358.2| (AB010284) dihydroorotase
[Trypanosoma cruzi] >gi|5509903|dbj|BAA74522.2|
(AB017765) DHOase [Trypanosoma cruzi]
Length = 383
Score = 146 bits (366), Expect = 3e-34
Identities = 125/388 (32%), Positives = 175/388 (44%), Gaps = 67/388 (17%)
Query: 47 KIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPV--MDEKTLKM 104
++ LP L+D HVH R+ K + + ++AA GGI V DMPNTKPP + T K+
Sbjct: 3 RVELPVLVDCHVHFREPGLEQKGDMRSESEAAYAGGIGVVCDMPNTKPPTQTITAFTEKV 62
Query: 105 REFLFKKKSYADYALGFLLAGNEPV-----------------KADFYKIFMGASTGGIYS 147
R +K + D L F +E + + K+++ STG + S
Sbjct: 63 RRAKAVEK-FCDIRLFFGATAHEHLQELETLWTQPQHAALKARCAGLKLYLDNSTGNLKS 121
Query: 148 KNFEEDYA----KALDITSV-HAE----DYELISKYP---------ERPPIVEISAIKKA 189
+ A L+I V H E + E S P RP E ++I
Sbjct: 122 SADVTEAAFELCGKLEIPLVAHCEHATHNDEACSANPYTGPATHSLRRPVHSESASIAYG 181
Query: 190 LNAARKVKKPLHICHVSTREGLKEILEANIPW--VSFEVTPHHLFLTRKDYEK-SKLLKV 246
+ AR+ LH+ H+ST EGL+ + +A V+ EVTPHHLFLT DY +KV
Sbjct: 182 IELARRHGTRLHVAHLSTGEGLELVRQARAEGLHVTTEVTPHHLFLTTGDYGCCGARVKV 241
Query: 247 YPPLRDESDRRYLWEKL--DNVPIIASDHAPHTLEDKERGA---AGLPGLETEVALLLD- 300
PP+R LWE + V I +DHAPHTLE+K +G+P +E V LLL
Sbjct: 242 NPPVRPPEHHERLWEGVLDGTVNCIGTDHAPHTLEEKSDATNPPSGMPSIEVVVPLLLTV 301
Query: 301 --------------AVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKK 346
A+ L + D+V M NP RIF + G E F D+
Sbjct: 302 CAGRWPHPTAAMPKAIEARRLTIGDIVRLMHTNPNRIFGL---GLSEKSQRFF---DLSM 355
Query: 347 EWTIKAEEFYTKAGWTPYEGWKVRGKVI 374
EW +K + +K GW+PY W + GK I
Sbjct: 356 EWVVKESQLKSKCGWSPYANWHLVGKAI 383
>sp|P25995|PYRC_BACSU DIHYDROOROTASE (DHOASE) >gi|279573|pir||DEBSO dihydroorotase (EC
3.5.2.3) - Bacillus subtilis >gi|143388|gb|AAA21268.1|
(M59757) dihydroorotase [Bacillus subtilis]
>gi|2633923|emb|CAB13424.1| (Z99112) dihydroorotase
[Bacillus subtilis]
Length = 428
Score = 145 bits (361), Expect = 1e-33
Identities = 120/416 (28%), Positives = 188/416 (44%), Gaps = 39/416 (9%)
Query: 12 NGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETI 71
NG I V IT + + + KG ++ PG +D+HVH R+ KETI
Sbjct: 14 NGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHVHFREPGGEKKETI 73
Query: 72 ETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKS------YADYA---LGFL 122
ETG KAA GG TTV MPNT+P ++ ++ + K+ S YA +G
Sbjct: 74 ETGAKAAGRGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVLPYASITIRQIGDE 133
Query: 123 LAGNEPVKA----DFYKIFMGASTGGIYSKNFEEDYAKALDITSV-HAEDYELI------ 171
+ E +K F +G T G+ + + A A+D V H ED LI
Sbjct: 134 MTNFEALKEAGAFAFTDDGVGIQTAGMMYEAMKR--AAAIDKAIVAHCEDNSLIYGGSVH 191
Query: 172 -SKYPERPPIVEISAIKKALNAARKV-----KKPLHICHVSTREGLKEILEANIPW--VS 223
+ + + I ++ ++++ AR V H+CH+ST+E ++ + +A V+
Sbjct: 192 EGTFSKANGLNGIPSVCESVHIARDVLLLGANCHYHVCHISTKESVRVVRDAKKAGIRVT 251
Query: 224 FEVTPHHLFLTRKDYE-KSKLLKVYPPLRDESDRRYLWEKL--DNVPIIASDHAPHTLED 280
EV+PHHL L +D K+ PPLR DR L E L + IA+DHAPHT E+
Sbjct: 252 AEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEE 311
Query: 281 KERGAAGLPGLETEVALLLDAVNRGMLELWDVVEK------MSLNPARIFRIKNKGWGEG 334
K P + + A + + W +V + M++ P F + G
Sbjct: 312 KNTEMKLAPFRNCRLRNSIPASLHTLCQKWQLVTEAADLTYMTIKPCEAFGLPYGTLQTG 371
Query: 335 KDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVI 390
+ AD ++D++KE I E F +K TP+ G G + TI G++ E+ ++
Sbjct: 372 QAADITLIDLEKEAVIDKETFLSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLV 427
>sp|P48795|PYRC_LACLE DIHYDROOROTASE (DHOASE) >gi|11266161|pir||T46955 dihydroorotase (EC
3.5.2.3) [validated] - Lactobacillus leichmannii
>gi|1085058|emb|CAA55633.1| (X78999) dihydroorotase
[Lactobacillus leichmannii]
Length = 427
Score = 143 bits (358), Expect = 3e-33
Identities = 120/423 (28%), Positives = 199/423 (46%), Gaps = 44/423 (10%)
Query: 1 MELVLVGKFLYN-GRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVH 59
M ++L +Y G I + + KI L + ++ KGK++ PGL+D+H H
Sbjct: 1 MAILLKNGLVYQEGEFIKEDVLISGSKIQAIGLDLPEEGAEVYDLKGKLLAPGLVDIHEH 60
Query: 60 LRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADY-- 117
R+ T+KETI+TG++AA GG TTV MPN P D +T + + L + S
Sbjct: 61 YREPGFTYKETIKTGSEAASRGGFTTVCTMPNVDPIPDDLETFEKQVALNEANSCVHLKQ 120
Query: 118 -----------------------ALGFLLAGNEPVKAD-FYKIFMGASTGGI-YSKNFEE 152
A F G+ +A Y+ A+ G+ ++ ++
Sbjct: 121 YGAITEDLTSDKVVDMAALKEAGAFAFSNDGHGIQQAGTMYEAMQEAAKVGLAICEHIQD 180
Query: 153 D--YAKALDITSVHAEDYELISKYPERPPIVEISAIKKALNAARKVKKPLHICHVSTREG 210
D Y + AE+ L P + E + + + L A+ H CHVST+E
Sbjct: 181 DSLYHHGVMNAGKKAEELGL----PGILGVSESAQLARDLVLAQATGVHYHACHVSTKES 236
Query: 211 LKEILEANIPWVSF--EVTPHHLFLTRKDYEKSK-LLKVYPPLRDESDRRYLWEKL--DN 265
++ I A ++ E TPHHL L+ ++ + + K+ PPLR + D+ L E +
Sbjct: 237 VELIRIAKEYGINVTAEATPHHLLLSEEEIDGNNGYYKMNPPLRSKEDQFALIEGMLDGT 296
Query: 266 VPIIASDHAPHTLEDK----ERGAAGLPGLETEVALLLDA-VNRGMLELWDVVEKMSLNP 320
+ +IA+DHAPH+ E+K + A G+ G ET A L V G ++L +++ MS P
Sbjct: 297 IDLIATDHAPHSREEKAGDMRKAAFGIIGNETAFACLYTKFVKSGQMDLSLLLDLMSYQP 356
Query: 321 ARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRG 380
A++F + GK+AD A+ D+ + E++ +K TP+ G +V G +T + G
Sbjct: 357 AKLFGLDAGVLAPGKEADLAVFDLDHAEKLSEEDYLSKGVNTPFTGQEVYGMTALTFVSG 416
Query: 381 EIV 383
++V
Sbjct: 417 KLV 419
>emb|CAC12440.1| (AL445067) cad protein (human), dihydroorotase domain related
protein [Thermoplasma acidophilum]
Length = 414
Score = 143 bits (357), Expect = 4e-33
Identities = 127/428 (29%), Positives = 187/428 (43%), Gaps = 48/428 (11%)
Query: 1 MELVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHL 60
M+ + G F Y G+ + V DGKI + N K ILP D+HVH
Sbjct: 3 MDRAICGNFYYGGKFDYLEVIVSDGKIAGI---KKDAGNVPKTNYDGAILPAATDIHVHF 59
Query: 61 RDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALG 120
R ET KE +G+ +A++GG T V DMPN + P+ D + S+AD++L
Sbjct: 60 RTPGETEKEDFGSGSLSAIYGGTTYVMDMPNNRFPITDYNAFGDKLGSIDSTSFADFSLY 119
Query: 121 FLLAGNEPVKAD----FYKIFMGASTGGIYSKNFEEDYAKALD---------------IT 161
+ G + D K+++G ST ++ EE + ++ +
Sbjct: 120 SMETGKNAMLLDRRSIGLKVYLGGSTNSTGTEVIEEGDIRKINEMNYPVVFHGESERCLK 179
Query: 162 SVHAEDYELISKYPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPW 221
+ E+ L RP EI A K K K + HVS+ + L
Sbjct: 180 THQMEEKNLRDHNLARPIDCEIEAAKYVSGLDIKTK---IMAHVSSPDVTGNFLR----- 231
Query: 222 VSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRR-----YLWEKLDNVPIIASDHAPH 276
EVTPHHL L + KV PPLRD ++ Y+ K D I++SDHAPH
Sbjct: 232 ---EVTPHHLLL-NDEMPLGSFGKVNPPLRDSRTQKRLLDDYISGKFD---ILSSDHAPH 284
Query: 277 TLEDK---ERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSL-NPARIFRIKNKGWG 332
T +DK E +G+ G+ET V L L + ++ L DV+ + ++ NP IF IK
Sbjct: 285 TEDDKREFEFAKSGIIGVETRVPLFLALAQKKIVPL-DVLYRTAIENPPSIFGIKKGKIE 343
Query: 333 EGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGK 392
G DADF ++D I ++K +P+ G I+RG +V++ E I
Sbjct: 344 IGYDADFMVIDFTSMKRINDNRLHSKFPVSPFNGMDAIFP-SHVIMRGNVVIDRYEDISD 402
Query: 393 PRGERIVK 400
P G I K
Sbjct: 403 PMGVFIPK 410
>pir||B82954 probable dihydroorotase PA5541 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9951880|gb|AAG08926.1|AE004966_8
(AE004966) probable dihydroorotase [Pseudomonas
aeruginosa]
Length = 445
Score = 142 bits (354), Expect = 8e-33
Identities = 117/421 (27%), Positives = 196/421 (45%), Gaps = 41/421 (9%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFS-LRELKGDNKIKVEKGKIILPGLIDVHVHLR 61
L+ + + G++ +G + V+ G+I + + E G ++ G+ +LPG+ID VH R
Sbjct: 5 LIRNARMVNEGQVREGDLLVRHGRIERIAGCLENCGASREIDAAGRYLLPGMIDDQVHFR 64
Query: 62 DFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGF 121
+ K +I + ++AAV GGIT+ DMPNT+P + + L ++ L S A+Y F
Sbjct: 65 EPGYPQKGSIASESRAAVAGGITSFMDMPNTRPATLSLEALAEKKRLAAAHSVANYGFHF 124
Query: 122 --------LLAGNEPVKADFYKIFMGASTGGIYSKN---FEEDYAKALDITSVHAEDYEL 170
+A +P + K+FMGASTG + + E +A + H ED
Sbjct: 125 GVSRDNLDTVAALDPREVAAVKVFMGASTGDMLVDDLPTLERLFASVPTLLLSHCEDTPR 184
Query: 171 I--------SKYPERPPIVEISAIKK----------ALNAARKVKKPLHICHVSTREGLK 212
I ++ ER P I+ A+ A++ LH+ H+ST L
Sbjct: 185 IEANLARWRQRFGERIPAAAHPRIRDAEACYRSTALAVELAQRHGTLLHVLHLSTARELA 244
Query: 213 EILEANI--PWVSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKL--DNVP 267
+ + ++ EV HHL DY + LLK P ++ DR L L + +
Sbjct: 245 LFEDKPLCQKRITAEVCVHHLLFDDSDYARLGHLLKCNPAIKSREDRDALRRALAGNRLD 304
Query: 268 IIASDHAPHTLEDKE----RGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARI 323
+I +DHAPH +K+ + AGLP ++ + LL+ V G L L +V K S A +
Sbjct: 305 VIGTDHAPHAWAEKQQAYPQAPAGLPLVQHALPALLELVREGWLSLATLVAKTSHRVAEL 364
Query: 324 FRIKNKGW-GEGKDADFAIV-DMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGE 381
F I ++G+ EG AD +V +++ A ++ WTP+ ++ TI+ G+
Sbjct: 365 FAIADRGFLREGYWADLVLVSELEHPALASAMPLLSRCNWTPFRHRAFHHRIDTTIVSGQ 424
Query: 382 I 382
+
Sbjct: 425 L 425
>sp|P96081|PYRC_THEAQ DIHYDROOROTASE (DHOASE) >gi|1684761|emb|CAA70731.1| (Y09536)
dihydroorotase (DHOase) [Thermus aquaticus]
Length = 426
Score = 140 bits (350), Expect = 2e-32
Identities = 129/422 (30%), Positives = 190/422 (44%), Gaps = 52/422 (12%)
Query: 12 NGRIID--GSIGVKDGKITKFSLRELKGDNKIKVEKGK--IILPGLIDVHVHLRDFNETH 67
N R++D G G D I + + L+G +V G + PG +D+H HLR+ E
Sbjct: 6 NVRLVDAMGERGPLDVLIGEGRILSLEGGEAKQVVDGTGCFLAPGFLDLHAHLREPGEEV 65
Query: 68 KETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAGNE 127
KE + +G AAV GG T + MPNT PPV + ++ + K A L +
Sbjct: 66 KEDLFSGLLAAVRGGYTDLVSMPNTNPPVDTPEAVRALKEKAKALGLARLHPAAALTEKQ 125
Query: 128 PVKADFYKIFMGASTGGIY----SKNFEEDYAKALDI---------TSVHAEDYEL---- 170
K + G + + E+ A + +VHAED L
Sbjct: 126 EGKT-LTPAGLLQEAGAVLLTDDGRTNEDAGVLAAGLLMAAPLGLPVAVHAEDAGLRRNG 184
Query: 171 ---------ISKYPERPPIVEISAIKKALNAARKVKKP------LHICHVSTREGLKEIL 215
+ P PP E + I + L R + LH+ H+ST+ GL+ +
Sbjct: 185 VMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPATPRLHVQHLSTKRGLELVR 244
Query: 216 EAN---IPWVSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKL--DNVPII 269
EA +P V+ E TPHHL LT + L KV PPLR E DR L E L + I
Sbjct: 245 EAKRAGLP-VTAEATPHHLTLTEEALRTFDPLFKVAPPLRGEEDREALLEGLLDGTLDAI 303
Query: 270 ASDHAPHTLEDKE----RGAAGLPGLETEVALLLDAVN--RGMLELWDVVEKMSLNPARI 323
A+DHAPHT +KE R G+P LE LL ++ RG L +VE + P R+
Sbjct: 304 ATDHAPHTQAEKEMDLLRAPFGIPSLEVAFPLLYTELHLKRG-FPLRRLVELFTDGPRRV 362
Query: 324 FRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIV 383
+ EG +A ++D KE + + F +KA ++P+ GW++ G ++T++ G IV
Sbjct: 363 LGLPPLHLEEGTEASLVLLD-PKERPVDPQGFASKARFSPWTGWRLGGWPVLTLVEGRIV 421
Query: 384 ME 385
E
Sbjct: 422 HE 423
>emb|CAC14834.1| (AJ295151) putative allantoinase [Staphylococcus xylosus]
Length = 430
Score = 140 bits (350), Expect = 2e-32
Identities = 115/426 (26%), Positives = 205/426 (47%), Gaps = 53/426 (12%)
Query: 21 GVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIE---TGTKA 77
GVKDG I ++L ++ + +I+ PG++D HVH+ + ++++ E TGT+A
Sbjct: 1 GVKDGNIAAIG-QDLGEAEQVIDAQNQIVSPGMVDAHVHITEPGGGYRDSWEGYVTGTRA 59
Query: 78 AVHGGITTVFDMP-NTKPPVMDEKTLKMREFLFKKKSYADYA-LGFLLAGN--------E 127
A GG+T+ +MP N P ++ +++ + K + D A G L+ N +
Sbjct: 60 AAKGGVTSFIEMPLNQVPATTEQASIQAKFDAGKGELSVDVASYGGLVPYNLNGGIQELD 119
Query: 128 PVKADFYKIFMGASTGGIYSKNFE--EDY---------AKALDITSVHAEDYELISKYPE 176
YK F+ +FE +DY AK + S+HAE+ + + E
Sbjct: 120 EAGVVAYKAFLATCGDRSIEGDFENVDDYSLYEGMKQIAKTGKLLSIHAENATITDRLGE 179
Query: 177 ----------------RPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIP 220
RP E+ I+K + A++ +HI HV+ EG+ EI++A
Sbjct: 180 IAKANGETTLSAYVDSRPVFTEVEPIRKIILFAKETGCRVHIVHVACEEGVDEIIKAQQE 239
Query: 221 WV--SFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKLDN--VPIIASDHAP 275
V S E H+L+ +++ + ++K PP+R++S +W+++ N + + SDH+P
Sbjct: 240 GVDISCETCTHYLYFYKEELDDIGPVVKCSPPIREKSRLEGMWKRVLNGDIGFVTSDHSP 299
Query: 276 HTLEDKERGAA-----GLPGLETEVALLLD-AVNRGMLELWDVVEKMSLNPARIFRIKNK 329
T + K+ A G+ GL+ V +L D V + + L + ++ PA+ F ++ K
Sbjct: 300 CTPDLKDTDNAFEAWGGIAGLQNNVDILFDEGVQKRNMSLNKFADIIATAPAKRFGLEAK 359
Query: 330 GW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDE 388
G GKDADF ++ +T+ AE+ + +PY G ++ +V TILRGE + +
Sbjct: 360 GSIAVGKDADFVLIKPNAPYTLAAEDLAYRNKMSPYIGREIGAQVTQTILRGEEIYNQET 419
Query: 389 VIGKPR 394
I + R
Sbjct: 420 GISEKR 425
>sp|Q9RVC3|PYRC_DEIRA DIHYDROOROTASE (DHOASE) >gi|7471807|pir||E75437 dihydroorotase -
Deinococcus radiodurans (strain R1)
>gi|6458840|gb|AAF10679.1|AE001960_7 (AE001960)
dihydroorotase [Deinococcus radiodurans]
Length = 416
Score = 139 bits (348), Expect = 4e-32
Identities = 122/400 (30%), Positives = 194/400 (48%), Gaps = 42/400 (10%)
Query: 19 SIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIETGTKAA 78
S+ +++G I ++L + +I +G + P LI++H HLR+ +T KE + +G AA
Sbjct: 18 SLTIENGLIKGWNL---PAEGEIFDGQGGTLAPALIELHAHLREPGQTEKEDLASGLAAA 74
Query: 79 VHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLAGNEPVKAD-----F 133
GG TV MPNT+ PV+D+ L +R + K + L A + K +
Sbjct: 75 SAGGYGTVVCMPNTR-PVIDDPAL-VRSLIEKARGLGFARLRPAAAVTKGEKGEQLTEMS 132
Query: 134 YKIFMGA---STGGIYSKN-----FEEDYAKALD-ITSVHAEDYEL----------ISK- 173
Y GA + G+ ++N +YAK+L + SVHAED L +S+
Sbjct: 133 YLKEAGAVMFTDDGLTNENARVLRLGMEYAKSLGMVISVHAEDDALRAGGVMNEGPVSES 192
Query: 174 --YPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWVSFEVTP 228
P P + + + + LH+ H+ST L + +A +P V+ EV P
Sbjct: 193 LGLPGNPAAAAAARVARDMEIVALTGARLHVQHLSTARELDIVRDAKRRGLP-VTCEVCP 251
Query: 229 HHLFLTRKDYEK-SKLLKVYPPLRDESDRRYLWEKL--DNVPIIASDHAPHTLEDKERGA 285
HHL LT + + KV PPLR +D YL E L +V IA+DHAPHT +KER
Sbjct: 252 HHLDLTDESLRTFDAMYKVAPPLRTRADADYLLEGLLDGSVDCIATDHAPHTRAEKERDL 311
Query: 286 AGLPG--LETEVALLLDAVNRG-MLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIV 342
P E+A + G L L +++ M+ PAR+ G AD ++
Sbjct: 312 LDAPSGIAYIEIAFPIMWTRFGERLGLEKLIDLMTAGPARVMGWPEPSLEAGAPADMVVL 371
Query: 343 DMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEI 382
D++ E + EF +KA +TP++G K+RG ++T++ G++
Sbjct: 372 DLETEREVNPAEFKSKAKFTPWQGQKLRGFPLLTVVDGKV 411
>sp|Q44184|HYDA_AGRRD D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPASE)
>gi|1296441|emb|CAA62549.1| (X91070) D-hydantoinase
[Agrobacterium radiobacter]
Length = 457
Score = 130 bits (323), Expect = 3e-29
Identities = 122/446 (27%), Positives = 194/446 (43%), Gaps = 72/446 (16%)
Query: 12 NGRII--DG----SIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLR--DF 63
NG I+ DG +G+KDGKI + I G+ + PG IDVH H+ F
Sbjct: 7 NGTIVTADGISPADLGIKDGKIAQIGGTFGPAGRTIDAS-GRYVFPGGIDVHTHVETVSF 65
Query: 64 NETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFK------KKSYADY 117
N +T T T AA GG TT+ D ++ +RE + K KS DY
Sbjct: 66 NTQSADTFATATVAAACGGTTTIVDF------CQQDRGHSLREAVAKWDGMAGGKSAIDY 119
Query: 118 ALGFLLAGNEPVKADFYKIF--MGASTGGIY----SKNFEEDY---------AKALDITS 162
++ + ++ +G ++ ++ N +D AK +
Sbjct: 120 GYHIIVLDPTDSVIEELEVLPDLGITSFKVFMAYRGMNMIDDVTLLRTLDKAAKTGSLVM 179
Query: 163 VHAEDYE----LISKYP------------ERPPIVEISAIKKALNAARKVKKPLHICHVS 206
VHAE+ + L K+ RPP VE A +AL A V P++I H++
Sbjct: 180 VHAENGDAADYLRDKFVADGKTAPIYHALSRPPRVEAEATARALALAEIVNAPIYIVHLT 239
Query: 207 TREGLKEILEANIPWVSF--EVTPHHLFLT-----RKDYEKSKLLKVYPPLRDESDRRYL 259
E E++ A V E +L+LT R D+E +K + PP R + D+ L
Sbjct: 240 CEESFDELMRAKARGVHALAETCTQYLYLTKDDLERPDFEGAKYVFTPPP-RTKKDQEIL 298
Query: 260 WEKLDN--VPIIASDHAPHTLED-KERGAA-------GLPGLETEVALLLDAVNRGMLEL 309
W L N + ++SDH E K+RG G PG+E + ++ VN G + L
Sbjct: 299 WNALRNGVLETVSSDHCSWLFEGHKDRGRNDFRAIPNGAPGVEERLMMVYQGVNEGRISL 358
Query: 310 WDVVEKMSLNPARIFRI-KNKGW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGW 367
VE ++ PA++F + KG G DAD + D + E I+ + ++ YEG
Sbjct: 359 TQFVELVATRPAKVFGMFPEKGTVAVGSDADIVLWDPEAEMVIEQSAMHNAMDYSSYEGH 418
Query: 368 KVRGKVIMTILRGEIVMEDDEVIGKP 393
K++G +LRG++++++ +G P
Sbjct: 419 KIKGVPKTVLLRGKVIVDEGTYVGAP 444
>sp|P71809|PYRC_MYCTU DIHYDROOROTASE (DHOASE) >gi|7435956|pir||B70959 probable
dihydroorotase - Mycobacterium tuberculosis (strain
H37RV) >gi|1621263|emb|CAB02642.1| (Z81011) pyrC
[Mycobacterium tuberculosis]
Length = 430
Score = 129 bits (322), Expect = 4e-29
Identities = 115/390 (29%), Positives = 179/390 (45%), Gaps = 53/390 (13%)
Query: 46 GKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKP----PVMDEKT 101
G ++LPG +D+H HLR+ + E IETG+ AA GG T VF M NT P PV+ +
Sbjct: 46 GHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHV 105
Query: 102 LKMREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEED-------- 153
+ + + A+ LAG E + + G + F +D
Sbjct: 106 WHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMM------NAGAAQVRMFSDDGVCVHDPL 159
Query: 154 -------YAKALDIT-SVHAEDYEL-ISKYPERPPIV------------EISAIKKALNA 192
YA L + + HAE+ L + P+ E S + +
Sbjct: 160 IMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALL 219
Query: 193 ARKVKKPLHICHVS---TREGLKEILEANIPWVSFEVTPHHLFLTRKDYEK-SKLLKVYP 248
AR +HICH S T E LK + I ++ EVTPHHL L + +V P
Sbjct: 220 ARDAGARVHICHASAAGTVEILKWAKDQGIS-ITAEVTPHHLLLDDARLASYDGVNRVNP 278
Query: 249 PLRDESDRRYLWEKLDN--VPIIASDHAPHTLEDK--ERGAA--GLPGLETEVALLLDA- 301
PLR+ SD L + L + + +A+DHAPH +K E AA G+ GL+T +++++
Sbjct: 279 PLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTM 338
Query: 302 VNRGMLELWDVVEKMSLNPARIFRIKNKG--WGEGKDADFAIVDMKKEWTIKAEEFYTKA 359
V G+L D+ MS NPA I R+ ++G G+ A+ +VD WT+ + +++
Sbjct: 339 VAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRS 398
Query: 360 GWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
TP+E + V T+LRG++ D ++
Sbjct: 399 ANTPFESMSLPATVTATLLRGKVTARDGKI 428
>sp|O08357|PYRC_SULAC DIHYDROOROTASE (DHOASE) >gi|2065441|emb|CAA73353.1| (Y12823)
dihydroorotase [Sulfolobus acidocaldarius]
Length = 355
Score = 129 bits (322), Expect = 4e-29
Identities = 103/356 (28%), Positives = 174/356 (47%), Gaps = 35/356 (9%)
Query: 47 KIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMRE 106
++ILP +D+HVH+R ++KET+ T T AV+GG+ + DMPNT P + + +K R
Sbjct: 7 ELILPASVDLHVHVRGAQLSYKETVATATSEAVYGGVGVIVDMPNTVPYINTPERIKERL 66
Query: 107 FLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAE 166
F+ S DY + + E + D I + IY ++ E++ + V +
Sbjct: 67 REFQLYSRTDYGI-YSGVSKEVEEIDKLPI----AGYKIYPEDLEKE-----ETRYVLEK 116
Query: 167 DYELISKYPERPPIVEISAIKKALN--------AARKVKKPLHICHVSTREGLKEILEAN 218
+L +PE P +S I+++L A VK +HI H++ E L+ A
Sbjct: 117 SKKLKILHPEMP---FVSKIERSLRRSYWMETAAINLVKGNMHITHITNFETLQ---LAK 170
Query: 219 IPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEK-LDNVPIIASDHAPHT 277
+ ++T HHL + D E+ + KV PP+RD R L+ K L V IASDHAPH+
Sbjct: 171 SMGFTTDITAHHLVV---DGERDCISKVNPPIRDYVTRLKLFLKGLFEVDCIASDHAPHS 227
Query: 278 LEDKERG----AAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGE 333
E+K G+ G+ + + +G++ + V +S NP+RI I E
Sbjct: 228 KEEKRMNFDLCPPGIAGVSFSTPYIYSLMFKGLISIDRAVSLLSGNPSRILNIPTGKIKE 287
Query: 334 GKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
G A+F ++ ++ W + ++K TP +G+ + KV I+ G++ + + V
Sbjct: 288 GYRANFTVI-KRENWRYTTK--FSKVTETPMDGFSLDAKVTNVIVEGKLAFDGENV 340
>sp|Q9RKU5|ALN_STRCO PROBABLE ALLANTOINASE >gi|6273652|emb|CAB60166.1| (AL132824)
putative allantoinase [Streptomyces coelicolor]
Length = 445
Score = 127 bits (316), Expect = 2e-28
Identities = 110/388 (28%), Positives = 175/388 (44%), Gaps = 40/388 (10%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMP-NTKPPVMDEKTLKMRE 106
++LPGL+D HVH+ D T E T T+AA GGITT+ DMP N+ PP L+ +
Sbjct: 54 VVLPGLVDTHVHVNDPGRTEWEGFWTATRAAAAGGITTLVDMPLNSIPPTTTVDNLRTKR 113
Query: 107 FLFKKKSYADYAL-GFLLAGN-------EPVKADFYKIFMGASTGGIYSKNFEEDYAKAL 158
+ K++ D G L N +K F+ S + +E A++L
Sbjct: 114 EVAADKAHIDVGFWGGALPDNVKDLRPLHEAGVFGFKAFLSPSGVDEFPHLDQEQLARSL 173
Query: 159 -------DITSVHAEDYELISKYPE------------RPPIVEISAIKKALNAARKVKKP 199
+ VHAED ++ P+ RP E +AI L A++
Sbjct: 174 AEIAAFDGLLIVHAEDPHHLAAAPQQGGPKYTHFLASRPRDAEDTAIATLLAQAKRFNAR 233
Query: 200 LHICHVSTREGLKEILEANIPW--VSFEVTPHHLFLTRKDY-EKSKLLKVYPPLRDESDR 256
+H+ H+S+ + L I EA V+ E PH+L LT ++ + + K PP+R+ +++
Sbjct: 234 VHVLHLSSSDALPLIAEARADGVRVTVETCPHYLTLTAEEVPDGASEFKCCPPIREAANQ 293
Query: 257 RYLWEKL--DNVPIIASDHAPHTLEDKERGAA----GLPGLETEVALLLDAVNRGMLELW 310
LW+ L + + +DH+P T + K A G+ GL+ + + A L L
Sbjct: 294 DLLWQALADGTIDCVVTDHSPSTADLKTDDFATAWGGIAGLQLSLPAMWTAARGRGLGLE 353
Query: 311 DVVEKMSLNPARIFRI--KNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWK 368
DVV MS A + + + G DADFA++ + +T+ + T Y G
Sbjct: 354 DVVRWMSERTAALVGLDARKGAIAPGHDADFAVLAPDETFTVDPAALQHRNRVTAYAGKT 413
Query: 369 VRGKVIMTILRGEIVMEDDEVIGKPRGE 396
+ G V T LRGE ++ D P+G+
Sbjct: 414 LYGVVKSTWLRGERIVADG-AFTDPKGQ 440
>gb|AAF48826.1| (AE003508) CG6106 gene product [Drosophila melanogaster]
Length = 499
Score = 123 bits (307), Expect = 3e-27
Identities = 120/429 (27%), Positives = 183/429 (41%), Gaps = 79/429 (18%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMP-NTKPPVMDEKTLKMRE 106
+++PGLID +VH+ + E T TKAA GG TT+ D P N +PP + LK +
Sbjct: 62 VLMPGLIDPNVHINEPGRKDWEGFATATKAAAAGGFTTIIDRPTNAQPPTVSVAHLKAKT 121
Query: 107 FLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGI----------YSKNF------ 150
+ K Y D +GF G P D +GA G+ S+ F
Sbjct: 122 STARGKIYVD--VGF-WGGLVPGNGDQLAALLGAGVMGLQCTLCDPAAPVSQEFPAVNES 178
Query: 151 ---------EEDYAKALDITSVHAE---------DYELISKY----PERPPIVEISAIKK 188
++D A+ I +VHAE D E +Y RPP +EISA +
Sbjct: 179 QLEEALSQLDKDQAEGEAIVAVHAELPLTTEIHPDEEAPREYGTFLVTRPPQMEISATQL 238
Query: 189 ALNAA-RKVKKPLHICHVSTREGLKEILEANIPW--VSFEVTPHHLFLTRKDY-EKSKLL 244
A R ++ +HI + S+ E L + E ++ + PH+L L +D +
Sbjct: 239 LCRLANRHPRRCIHILNCSSGESLPLVEECRRQGGNLTVDTCPHYLALAAEDVPDCGTEF 298
Query: 245 KVYPPLRDESDRRYLWEKL---DNVPIIASDHAPHT------------------------ 277
K +PP+R+ ++ LW+ L + +I SDH+P T
Sbjct: 299 KTWPPIRERRNQEQLWQALRPGGAIRMIGSDHSPATPGARALTCGRGRGNFLKAWPGINS 358
Query: 278 ----LEDKERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIK-NKG-W 331
L AA G LL + L + D+ M PA + + +KG
Sbjct: 359 LQLSLSVVWTAAANRRGFHNSRTHLLFSPGSANLTIADIHRLMCQEPANLCGLSASKGRI 418
Query: 332 GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIG 391
EG DADF + ++E+T+ E YT TPY G K+RG V T++RG V + E G
Sbjct: 419 AEGYDADFCVWSPEEEFTVGPELLYTATKATPYAGQKLRGVVHATVVRGLHVYQQFEGFG 478
Query: 392 KPRGERIVK 400
+P G+ +++
Sbjct: 479 QPLGKVLLR 487
>sp|O32137|ALN_BACSU PROBABLE ALLANTOINASE >gi|7428265|pir||C70016 allantoinase homolog
yunH - Bacillus subtilis >gi|2635738|emb|CAB15231.1|
(Z99120) similar to allantoinase [Bacillus subtilis]
Length = 446
Score = 123 bits (307), Expect = 3e-27
Identities = 116/430 (26%), Positives = 192/430 (43%), Gaps = 48/430 (11%)
Query: 15 IIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIETG 74
+I+ I V++G I + +I GK + PG+ID HVH + E ETG
Sbjct: 18 VIEADIVVQNGVIAEIGSDIEASGTEIIQADGKYVFPGVIDCHVHFNEPGREDWEGFETG 77
Query: 75 TKAAVHGGITTVFDMP-NTKPPVMDEKTLKMREFLFKKKSYADYAL-GFLLAGN-EPVK- 130
++ GG TT FDMP N P + + L + L ++KS D+AL G L+ G+ E ++
Sbjct: 78 SQMMAAGGCTTYFDMPLNCIPSTVTAEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRP 137
Query: 131 -----ADFYKIFMGASTGGIYSKNFEE--------DYAKALDITSVHAEDYELISKY--- 174
A +K F+ S G ++ +E + A A I ++HAE + I+ Y
Sbjct: 138 MAEAGAIGFKAFLSKS-GTDEFRSVDERTLLKGMAEIAAAGKILALHAES-DAITSYLQM 195
Query: 175 --------------PERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIP 220
RP E+ A+ + + A+ P+H H+ST + ++ I EA
Sbjct: 196 VLANKGKVDADAYAASRPEEAEVEAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQE 255
Query: 221 W--VSFEVTPHHLFLTRKDY-EKSKLLKVYPPLRDESDRRYLWEKL--DNVPIIASDHAP 275
VS E PH++ + D ++ + K PPLR + L E L ++ +++SDH+P
Sbjct: 256 GLDVSVETCPHYVLFSHDDLRQRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSP 315
Query: 276 HTLEDKER-----GAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKG 330
K G+ G + + +L+ + + E + PA+ F ++ KG
Sbjct: 316 CRPSLKREDNMFLSWGGISGGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKG 375
Query: 331 WGE-GKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
E G DADF +V M + +T+ E + K + YEG + T +G V D E
Sbjct: 376 RLEAGCDADFVLVSM-EPYTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEK 434
Query: 390 IGKPRGERIV 399
+ + G +V
Sbjct: 435 VTEIDGALVV 444
>gi|6322218 allantoinase; Dal1p [Saccharomyces cerevisiae]
>gi|728828|sp|P32375|ALN_YEAST ALLANTOINASE
>gi|630082|pir||S48489 allantoinase (EC 3.5.2.5) - yeast
(Saccharomyces cerevisiae) >gi|557833|emb|CAA86187.1|
(Z38061) dal1, len: 460, CAI: 0.14, ALLA_YEAST P32375
ALLANTOINASE (EC 3.5.2.5) [Saccharomyces cerevisiae]
Length = 460
Score = 120 bits (299), Expect = 2e-26
Identities = 120/443 (27%), Positives = 200/443 (45%), Gaps = 78/443 (17%)
Query: 15 IIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIETG 74
+++GS+ ++ +ITK+ + L+ + ILPGL+D HVHL + T E ETG
Sbjct: 34 VLEGSVVMEKTEITKYEIHTLENVSPCT------ILPGLVDSHVHLNEPGRTSWEGFETG 87
Query: 75 TKAAVHGGITTVFDMP-NTKPPVMDEKTLKMREFLFKKKSYADYAL-GFLLAGNEP---- 128
T+AA+ GG+TTV DMP N PP + + +++ + + + D G L+ N P
Sbjct: 88 TQAAISGGVTTVVDMPLNAIPPTTNVENFRIKLEAAEGQMWCDVGFWGGLVPHNLPDLIP 147
Query: 129 -VKADF--YKIFM---GASTGGIYSKNFEEDYAKAL-----------DITSVHAEDYE-- 169
VKA +K F+ G K + E+ K L ++ H + +
Sbjct: 148 LVKAGVRGFKGFLLDSGVEEFPPIGKEYIEEALKVLAEEDTMMMFHAELPKAHEDQQQPE 207
Query: 170 --------LISKYPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---N 218
+S P+ I I+ I + L A P+HI H+++ + + I +A
Sbjct: 208 QSHREYSSFLSSRPDSFEIDAINLILECLRARNGPVPPVHIVHLASMKAIPLIRKARASG 267
Query: 219 IPWVSFEVTPHHLFLTRKDY-EKSKLLKVYPPLRDESDRRYLWEKLDN--VPIIASDHAP 275
+P V+ E H+L + + + + K PP+R ES+R+ LW+ L + + SDH+P
Sbjct: 268 LP-VTTETCFHYLCIAAEQIPDGATYFKCCPPIRSESNRQGLWDALREGVIGSVVSDHSP 326
Query: 276 HT--LEDKERG------------AAGLPGLETEVALLLDAVNRGMLELW---DVVEKMSL 318
T L++ ++G GLP + T+ L+D V W + ++ L
Sbjct: 327 CTPELKNLQKGDFFDSWGGIASVGLGLPLMFTQGCSLVDIVT------WCCKNTSHQVGL 380
Query: 319 NPARIFRIKNKGW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTI 377
+ KG G DAD + D + I Y K T Y G V+G V+ TI
Sbjct: 381 S-------HQKGTIAPGYDADLVVFDTASKHKISNSSVYFKNKLTAYNGMTVKGTVLKTI 433
Query: 378 LRGEIVMEDDEVIGK-PRGERIV 399
LRG++V + + K P G+ ++
Sbjct: 434 LRGQVVYTNANGVSKTPLGQTLL 456
>gb|AAA34553.1| (M69294) alantoinase [Saccharomyces cerevisiae]
Length = 472
Score = 116 bits (287), Expect = 6e-25
Identities = 116/424 (27%), Positives = 190/424 (44%), Gaps = 77/424 (18%)
Query: 15 IIDGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHLRDFNETHKETIETG 74
+++GS+ ++ +ITK+ + L+ + ILPGL+D HVHL + T E ETG
Sbjct: 34 VLEGSVVMEKTEITKYEIHTLENVSPCT------ILPGLVDSHVHLNEPGRTSWEGFETG 87
Query: 75 TKAAVHGGITTVFDMP-NTKPPVMDEKTLKMREFLFKKKSYADYAL-GFLLAGNEP---- 128
T+AA+ GG+TTV DMP N PP + + +++ + + + D G L+ N P
Sbjct: 88 TQAAISGGVTTVVDMPLNAIPPTTNVENFRIKLEAAEGQMWCDVGFWGGLVPHNLPDLIP 147
Query: 129 -VKADF--YKIFM---GASTGGIYSKNFEEDYAKAL-----------DITSVHAEDYE-- 169
VKA +K F+ G K + E+ K L ++ H + +
Sbjct: 148 LVKAGVRGFKGFLLDSGVEEFPPIGKEYIEEALKVLAEEDTMMMFHAELPKAHEDQQQPE 207
Query: 170 --------LISKYPERPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---N 218
+S P+ I I+ I + L A P+HI H+++ + + I +A
Sbjct: 208 QSHREYSSFLSSRPDSFEIDAINLILECLRARNGPVPPVHIVHLASMKAIPLIRKARASG 267
Query: 219 IPWVSFEVTPHHLFLTRKDY-EKSKLLKVYPPLRDESDRRYLWEKLDN--VPIIASDHAP 275
+P V+ E H+L + + + + K PP+R ES+R+ LW+ L + + SDH+P
Sbjct: 268 LP-VTTETCFHYLCIAAEQIPDGATYFKCCPPIRSESNRQGLWDALREGVIGSVVSDHSP 326
Query: 276 HT--LEDKERG------------AAGLPGLETEVALLLDAVNRGMLELW---DVVEKMSL 318
T L++ ++G GLP + T+ L+D V W + ++ L
Sbjct: 327 CTPELKNLQKGDFFDSWGGIASVGLGLPLMFTQGCSLVDIVT------WCCKNTSHQVGL 380
Query: 319 NPARIFRIKNKGW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTI 377
+ KG G DAD + D + I Y K T Y G V+G V+ TI
Sbjct: 381 S-------HQKGTIAPGYDADLVVFDTASKHKISNSSVYFKNKLTAYNGMTVKGTVLKTI 433
Query: 378 LRGE 381
LRG+
Sbjct: 434 LRGQ 437
>sp|Q45515|HYDA_BACST D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPASE)
>gi|628991|pir||JC2310 dihydropyrimidinase (EC 3.5.2.2)
- Bacillus stearothermophilus >gi|688288|gb|AAC60487.1|
(S73773) hydantoinase [Bacillus stearothermophilus,
NS1122A, Peptide, 471 aa] >gi|1090997|prf||2020276A
hydantoinase [Bacillus stearothermophilus]
Length = 471
Score = 112 bits (278), Expect = 6e-24
Identities = 119/455 (26%), Positives = 190/455 (41%), Gaps = 65/455 (14%)
Query: 8 KFLYNGRII------DGSIGVKDGKITKFSLRELKGDNKIKVEKGKIILPGLIDVHVHL- 60
K + NG I+ + + ++DGKI + ++ G + PG ID H HL
Sbjct: 3 KLIKNGTIVTATDIYEADLLIQDGKIAVIGRNLDESGAEVIDATGCYVFPGGIDPHTHLD 62
Query: 61 RDFNET-HKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYAL 119
F T K+ E+GT AA GG TT+ D T +K ++ K+ DY
Sbjct: 63 MPFGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKATGKAVIDYGF 122
Query: 120 GFLLAGN------------EPVKADFYKIFMG------ASTGGIYSKNFEEDYAKALDIT 161
+++ E +K+FM A G +Y AL
Sbjct: 123 HLMISEITDDVLEELPKVIEEEGITSFKVFMAYKDVFQADDGTLYRTLVAAKELGAL--V 180
Query: 162 SVHAEDYELISKYPE----------------RPPIVEISAIKKALNAARKVKKPLHICHV 205
VHAE+ ++I + RPP +E A +A L++ HV
Sbjct: 181 MVHAENGDVIDYLTKKALEDGHTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHV 240
Query: 206 STREGLKEILEANIPWVSF--EVTPHHL-----FLTRKDYEKSKLLKVYPPLRDESDRRY 258
S + +++I EA ++ E P +L +L + ++E +K + PPLR++ +
Sbjct: 241 SCAQAVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWS-PPLREKWHQEV 299
Query: 259 LWEKLDN--VPIIASDHAPHTLE-DKERGAA-------GLPGLETEVALLL-DAVNRGML 307
LW L N + + SD + KE G G P +E V++L + V +G +
Sbjct: 300 LWNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRI 359
Query: 308 ELWDVVEKMSLNPARIFRI--KNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYE 365
L V+ +S A++F + K G DAD I D E I AE + + P+E
Sbjct: 360 TLNQFVDIVSTRIAKLFGLFPKKGTIAVGADADLVIFDPTVERVISAETHHMAVDYNPFE 419
Query: 366 GWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVK 400
G KV G+ + + RGE V+ D + +GKP + VK
Sbjct: 420 GMKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYVK 454
>sp|Q9WYH0|PYRC_THEMA DIHYDROOROTASE (DHOASE) >gi|7462364|pir||A72391 dihydroorotase -
Thermotoga maritima (strain MSB8)
>gi|4980836|gb|AAD35422.1|AE001714_13 (AE001714)
dihydroorotase [Thermotoga maritima]
Length = 376
Score = 111 bits (276), Expect = 1e-23
Identities = 106/363 (29%), Positives = 176/363 (48%), Gaps = 33/363 (9%)
Query: 45 KGKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKM 104
KG + +D+HVH+R ++E +A++ GG V PNTKP + ++ L+
Sbjct: 23 KGLVATFPFVDLHVHVRLNGGEDYSSLE---EASLVGGFFKVVVQPNTKPLIDSKEVLER 79
Query: 105 REFLFKKKSYADYALGFLLAGNE--PVKADFYKIFMGASTGGI---YSKNFEEDYAKALD 159
L K + A+ FL A + ++A+ ++ +G ST GI Y E K
Sbjct: 80 HLDLSKNR-----AVEFLFAVSPFGSIEAEGERV-VGFSTDGIEYDYPTLVETMKKKKKA 133
Query: 160 ITSVHAEDYELISKYPERPPIV--EISAIKKALNAARKVKKPL-------HICHVSTREG 210
+ H++ YE+ + E P+ + +A+ AR V L HI HV+T+
Sbjct: 134 LWFDHSQMYEVDGIFYEGAPLPFQKRPRSNEAIAIARTVLTGLEYGFERFHIQHVTTKYS 193
Query: 211 LKEI-LEANIPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWE--KLDNVP 267
++ I N+ VS EVTPHHLF +D + + K+ PPL DRR L E K D +
Sbjct: 194 VEVISFLKNLAKVSCEVTPHHLFFCYEDIKNTNF-KINPPLGSPEDRRALIEAVKKDVID 252
Query: 268 IIASDHAPHTLEDKERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIK 327
++A+DHAPH + + A E+A G LEL VV+K++ P + ++
Sbjct: 253 VLATDHAPHHEKPDDFLTAPYGSTSIEIAFPAYYTALGDLEL--VVKKLTKKPLEVLGVE 310
Query: 328 NKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDD 387
+ + +D + E+ + A++F +K + ++G +++GKV+ L+G VM D
Sbjct: 311 ARL----TEDTLVFIDPEAEFIVDAKKFKSKGKNSMFDGVRLKGKVVALKLKGRWVMIDG 366
Query: 388 EVI 390
EVI
Sbjct: 367 EVI 369
>sp|Q9YFI5|PYRC_AERPE DIHYDROOROTASE (DHOASE) >gi|7435958|pir||F72784 probable
dihydroorotase APE0261 - Aeropyrum pernix (strain K1)
>gi|5103655|dbj|BAA79176.1| (AP000058) 429aa long
hypothetical dihydroorotase [Aeropyrum pernix]
Length = 429
Score = 111 bits (276), Expect = 1e-23
Identities = 114/411 (27%), Positives = 192/411 (45%), Gaps = 49/411 (11%)
Query: 9 FLYNG-RIIDGSIGVKDG-KITKFSLRELKGDNKIKVE-KGKIILPGLIDVHVHLRDFNE 65
FLY G ++++ + V G ++ + +G + + + + LPG+ID+HVHLR
Sbjct: 14 FLYTGDKMLEDACAVISGERVERVHTGGFRGQPDLDLRGRSSLALPGVIDMHVHLRGLKL 73
Query: 66 THKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYAL--GFLL 123
++KE +GT AA G +T V DMPNT+PP+ + L+ + + + DY + G
Sbjct: 74 SYKEDEVSGTAAAASGCVTLVADMPNTQPPLRTPEALREKLASLEAGAKVDYTVYAGVPR 133
Query: 124 AGNEPVKADF-----YKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYELIS------ 172
+ E V+ +KI+ KN E +A + +H E +++ +
Sbjct: 134 SYGEAVEMASMGIAGFKIYPEDLVNLDSIKNVLEAAEEAGILVVLHPESHDMFAGPDYGW 193
Query: 173 -KYPERPPIVEISAIKKALNAARK--VKKPLHICHVSTREGLKEILEANIPWVSFEVTPH 229
+ RP E ++++ +AAR+ K +HI H S ++E+ + +VTPH
Sbjct: 194 LRRVARPCHAEAASVELLHDAARECGCKPRVHITHASCP---ATVVESKKRGFTVDVTPH 250
Query: 230 HLFLTRKDY--EKSKLLKVYPPLRDESDRRYLWEKLDN--VPIIASDHAPHTLEDKERGA 285
HLFL+ ++ KV PPLR +R L + V IASDHAPH+ +K
Sbjct: 251 HLFLSEEEVAGPTHSWGKVNPPLRGVGERSLLTQLTIEGLVDAIASDHAPHSTWEKWMHP 310
Query: 286 A----GLPGLE----TEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDA 337
A G P LE A L+ AV G+ + +V S P+ I + ++ +G A
Sbjct: 311 AIAPPGFPWLEWWPGFTAARLMRAV--GLERFYSMV---SQTPSTILGVGDRCLWDGCPA 365
Query: 338 DFAIVDMKKEWTIKAEEFYTKAGWTPYEGWK--------VRGKVIMTILRG 380
+++ +++ T + YTKA +TP G + +RGK+ T G
Sbjct: 366 TISVLQLER--TRVYHKGYTKALYTPVLGMESFDCAATVIRGKIAYTAWEG 414
>pir||T28685 hypothetical protein - Streptomyces coelicolor
>gi|3127836|emb|CAA18902.1| (AL023496) hypothetical
protein [Streptomyces coelicolor A3(2)]
Length = 467
Score = 109 bits (269), Expect = 7e-23
Identities = 113/436 (25%), Positives = 183/436 (41%), Gaps = 62/436 (14%)
Query: 16 IDGSIGVKDGKITKFSLRELKGDNKIKVEK-----GKIILPGLIDVHVHLR-DFNETHK- 68
I + ++DG++ + E GK ++PG +D H H+ F T+
Sbjct: 19 IHADVLIEDGRVAALAATGTPAAEAFTAENVIDASGKYVIPGGVDGHTHMEMPFGGTYAA 78
Query: 69 ETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGFLLA--GN 126
+T ETGT+AA GG TT+ D + L + DY +++
Sbjct: 79 DTFETGTRAAAWGGTTTIVDFAIQSVGHSLREGLDAWHAKAEGNCAIDYGFHMIVSDVNQ 138
Query: 127 EPVK---------ADFYKIFMGASTGGIYSKNFE-----EDYAKALDITSVHAEDYELIS 172
E +K +K FM A G YS + + + A+ + +HAE+ I
Sbjct: 139 ETLKEMDLLVEEGVTSFKQFM-AYPGVFYSDDGQILRAMQRAAENGGLIMMHAENGIAID 197
Query: 173 KYPE----------------RPPIVEISAIKKALNAARKVKKPLHICHVSTREGLKEILE 216
E R ++E A +A+ A+ PL++ HVS E + E+
Sbjct: 198 VLVEQALARGETDPRFHGEVRKALLEAEATHRAIRLAQVAGAPLYVVHVSATEAVAELTR 257
Query: 217 AN---IPWVSFEVTPHHLFLT-----RKDYEKSKLLKVYPPLRDESDRRYLWEKL--DNV 266
A +P V E P +LFL+ D+E +K + PLR + + LW L +++
Sbjct: 258 ARDEGLP-VFGETCPQYLFLSTDNLAEPDFEGAKYV-CSTPLRPKEHQAALWRGLRTNDL 315
Query: 267 PIIASDHAPHTLE-DKERGAA-------GLPGLETEVALLLDAVNRGMLELWDVVEKMSL 318
++++DH P KE G G+PG+E + LL AV G + +E
Sbjct: 316 QVVSTDHCPFCFSGQKELGRGDFSRIPNGMPGVENRMDLLHQAVVEGHIGRRRWIEIACA 375
Query: 319 NPARIFRI--KNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMT 376
PAR+F + K G DAD + D E I AE + ++ YEG ++ G+V
Sbjct: 376 TPARMFGLYPKKGTIAPGADADIVVYDPHAEQVISAETHHMNVDYSAYEGRRITGRVETV 435
Query: 377 ILRGEIVMEDDEVIGK 392
+ RGE V+ + E G+
Sbjct: 436 LSRGEPVVTEREYTGR 451
>sp|Q59699|HYDA_PSEPU D-HYDANTOINASE (DIHYDROPYRIMIDINASE) (DHPASE)
>gi|2828803|gb|AAC00209.1| (U84197) D-hydantoinase
[Pseudomonas putida]
Length = 495
Score = 104 bits (257), Expect = 2e-21
Identities = 113/415 (27%), Positives = 180/415 (43%), Gaps = 62/415 (14%)
Query: 38 DNKIKVEKGKIILPGLIDVHVHLR--DFNETHKETIETGTKAAVHGGITTVFD--MPNTK 93
D +I G+ ++PG ID H H++ E +GT A + GG T++ D +PN +
Sbjct: 40 DCEILDGSGQYLMPGGIDPHTHMQLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVIPNPQ 99
Query: 94 PPVMDEKTLKMREFLFKKKSYADYALGFLLA---GNEPVKADF-----------YKIFMG 139
+++ + +KS +DY GF +A +E V + +K FM
Sbjct: 100 QSLLEAFHTWRG---WAQKSASDY--GFHVAITWWSEQVAEEMGELVAKHGVNSFKHFMA 154
Query: 140 ASTGGIYSKN-FEEDYAKALD---ITSVHAEDYELISKY-----------PE-----RPP 179
+ + + + + L + +VHAE+ EL+ PE RP
Sbjct: 155 YKNAIMAADDTLVASFERCLQLGAVPTVHAENGELVYHLQKKLLAQGMTGPEAHPLSRPS 214
Query: 180 IVEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPW--VSFEVTPHHLFLTRK- 236
VE A +A+ A + PL++ H+S+RE L EI A V EV P HL L
Sbjct: 215 QVEGEAASRAIRIAETIGTPLYVVHISSREALDEITYARAKGQPVYGEVLPGHLLLDDSV 274
Query: 237 ----DYEKSKLLKVYPPLRDESDRRYLWEKLD--NVPIIASDHAPHTLEDKERG------ 284
D+ + + PP R + LW L N+ A+DH E K G
Sbjct: 275 YRDPDWATAAGYVMSPPFRPREHQEALWRGLQSGNLHTTATDHCCFCAEQKAMGRDDFSR 334
Query: 285 -AAGLPGLETEVALLLDA-VNRGMLELWDVVEKMSLNPARIFRI--KNKGWGEGKDADFA 340
G G+E +A+L DA VN G L + + V S N A+IF + + G DAD
Sbjct: 335 IPNGTAGIEDRMAVLWDAGVNSGRLSMHEFVALTSTNTAKIFNLFPRKGAIRVGADADLV 394
Query: 341 IVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRG 395
+ D + T+ A+ + + + +EG VRG TI +G+++ D ++ + RG
Sbjct: 395 LWDPQGTRTLSAQTHHQRVDFNIFEGRTVRGVPSHTISQGKVLWADGDLRRRGRG 449
>sp|Q46806|YGEZ_ECOLI HYPOTHETICAL 51.5 KD PROTEIN IN PBL-LYSS INTERGENIC REGION
>gi|7435959|pir||A65071 hypothetical protein b2873 -
Escherichia coli (strain K-12) >gi|887823|gb|AAA83054.1|
(U28375) UUG start [Escherichia coli]
>gi|1789237|gb|AAC75911.1| (AE000370) orf, hypothetical
protein [Escherichia coli K12]
Length = 465
Score = 103 bits (255), Expect = 3e-21
Identities = 113/410 (27%), Positives = 178/410 (42%), Gaps = 60/410 (14%)
Query: 46 GKIILPGLIDVHVHLR-DFNETHK-ETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLK 103
G + PG +DVH H D + TGT+AA GG TT+ D P +
Sbjct: 52 GCYVFPGGVDVHTHFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGP-----NGCR 106
Query: 104 MREFLFKKKSYA------DYAL-GFLLAGNEPVKADFYKIFM-GASTGGIYS----KNFE 151
+R L + YA DY+ G + N + + I G S+ +Y K +
Sbjct: 107 LRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMIVEEGLSSFKLYLTYQYKLND 166
Query: 152 EDYAKALD-------ITSVHAE-DYELISKYPE---------------RPPIVEISAIKK 188
++ +AL +T+VH E D + SK E RP E AI +
Sbjct: 167 DEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIAR 226
Query: 189 ALNAARKV-KKPLHICHVSTREGLK--EILEANIPWVSFEVTPHHLFLTRKDYEKSKLLK 245
+N A+ PL+I H+S GL + AN V E P +L L + Y+ +K
Sbjct: 227 MINLAQIAGNAPLYIVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMK 286
Query: 246 --VYPPLRDESDRRYLWEKLDN--VPIIASDHAPHTLE--------DKERGAAGLPGLET 293
+ PPLR+ ++ LW + + + ++A+DH ++ D R GLPG+E
Sbjct: 287 FILSPPLRNVREQDKLWCGISDGAIDVVATDHCTFSMAQRLQISKGDFSRCPNGLPGVEN 346
Query: 294 EVALLLDA-VNRGMLELWDVVEKMSLNPARIFRI-KNKGW-GEGKDADFAIVDMKKEWTI 350
+ LL + V G + VE S PAR+F + KG G D D I+D ++ I
Sbjct: 347 RMQLLFSSGVMTGRITPERFVELTSAMPARLFGLWPQKGLLAPGSDGDVVIIDPRQSQQI 406
Query: 351 KAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVK 400
+ + A ++P+EG+ +G ++ T+ RGE + D GK R ++
Sbjct: 407 QHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLR 456
>pir||H83590 dihydropyrimidinase PA0441 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9946299|gb|AAG03830.1|AE004481_6
(AE004481) dihydropyrimidinase [Pseudomonas aeruginosa]
Length = 479
Score = 102 bits (251), Expect = 9e-21
Identities = 111/414 (26%), Positives = 179/414 (42%), Gaps = 66/414 (15%)
Query: 46 GKIILPGLIDVHVHLR--DFNETHKETIETGTKAAVHGGITTVFD--MPNTKPPVMDE-K 100
G+ ++PG ID H H++ E +GT A + GG T++ D +PN + +++
Sbjct: 48 GQYLMPGGIDPHTHMQLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVIPNPRQSLLEAFH 107
Query: 101 TLKMREFLFKKKSYADYA---------------LGFLLAGNEPVKADFYKIFMGASTGGI 145
T + + +KS ADY +G L+A + + +K FM +
Sbjct: 108 TWRG----WAQKSAADYGFHVAITWWSDEVAREMGELVAQH---GVNSFKHFMAYKNAIM 160
Query: 146 YSKN-FEEDYAKALD---ITSVHAEDYELI---------------SKYP-ERPPIVEISA 185
+ + + + L+ + +VHAE+ EL+ +P RPP VE A
Sbjct: 161 AADDTLVASFERCLELGAVPTVHAENGELVFHLQQKLLAQGLTGPEAHPLSRPPQVEGEA 220
Query: 186 IKKALNAARKVKKPLHICHVSTREGLKEILEANIPW--VSFEVTPHHLFL-----TRKDY 238
+A+ A + PL++ H+S+RE L EI A V EV HL L D+
Sbjct: 221 ASRAIRIAETLGTPLYLVHISSREALDEIAYARAKGQPVYGEVLAGHLLLDDSVYRHPDW 280
Query: 239 EKSKLLKVYPPLRDESDRRYLWEKLD--NVPIIASDHAPHTLEDKERG-------AAGLP 289
+ + PP R + LW L N+ A+DH E K G G
Sbjct: 281 ATAAGYVMSPPFRPVEHQEALWRGLQSGNLHTTATDHCCFCAEQKAMGRDDFSKIPNGTA 340
Query: 290 GLETEVALLLDA-VNRGMLELWDVVEKMSLNPARIFRI--KNKGWGEGKDADFAIVDMKK 346
G+E +ALL DA VN G L + + V S N A+IF + + G DAD + D +
Sbjct: 341 GIEDRMALLWDAGVNSGRLSMHEFVALTSTNTAKIFNLFPRKGAIRVGADADLVLWDPQG 400
Query: 347 EWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVK 400
T+ A + + + +EG VRG TI +G+++ ++ +P R V+
Sbjct: 401 SRTLSAATHHQRVDFNIFEGRTVRGIPSHTISQGKLLWAAGDLRAEPGAGRYVE 454
>dbj|BAB10038.1| (AB007727) dihydropyrimidinase [Arabidopsis thaliana]
Length = 531
Score = 96.7 bits (237), Expect = 4e-19
Identities = 115/414 (27%), Positives = 177/414 (41%), Gaps = 67/414 (16%)
Query: 46 GKIILPGLIDVHVHLR-DFNETHKETIE---TGTKAAVHGGITTVFDMPNTKPPVMDEKT 101
GK ++PG ID H HL +F T ETI+ +G AA+ GG T D PV
Sbjct: 92 GKFVMPGGIDPHTHLAMEFMGT--ETIDDFFSGQAAALAGGTTMHIDFVI---PVNGNLV 146
Query: 102 LKMREFLFK-KKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDI 160
+ K ++S DY GF +A + + + M GI S F Y +L +
Sbjct: 147 AGFEAYENKSRESCMDY--GFHMAITKWDEGVSRDMEMLVKEKGINSFKFFLAYKGSLMV 204
Query: 161 TS------------------VHAED-----------YELISKYPE-----RPPIVEISAI 186
T VHAE+ EL PE RPP++E A
Sbjct: 205 TDDLLLEGLKRCKSLGALAMVHAENGDAVFEGQKRMIELGITGPEGHALSRPPVLEGEAT 264
Query: 187 KKALNAARKVKKPLHICHVSTREGLKEILEANI--------PWVSFEVTPHHLFLTRKDY 238
+A+ AR + PL++ HV + + + EI +A P VS + H +L D+
Sbjct: 265 ARAIRLARFINTPLYVVHVMSVDAMDEIAKARKSGQKVIGEPVVSGLILDDH-WLWDPDF 323
Query: 239 EKSKLLKVYPPLRDESDRRYLWEKLDN--VPIIASDHAPHT-------LEDKERGAAGLP 289
+ + PP+R + L + L + ++ +DH L+D R G+
Sbjct: 324 TIASKYVMSPPIRPVGHGKALQDALSTGILQLVGTDHCTFNSTQKALGLDDFRRIPNGVN 383
Query: 290 GLETEVALLLDA-VNRGMLELWDVVEKMSLNPARIFRIKNKGWG--EGKDADFAIVDMKK 346
GLE + L+ D V G L D V S ARIF I + G DAD I++
Sbjct: 384 GLEERMHLIWDTMVESGQLSATDYVRITSTECARIFNIYPRKGAILAGSDADIIILNPNS 443
Query: 347 EWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVIGKPRGERIVK 400
+ I ++ ++++ YEG + +GKV +TI G IV E++E+ PR + ++
Sbjct: 444 SYEISSKSHHSRSDTNVYEGRRGKGKVEVTIAGGRIVWENEELKVVPRSGKYIE 497
>pir||G83595 noncatalytic dihydroorotase-like protein PA0401 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9946255|gb|AAG03790.1|AE004477_7 (AE004477)
noncatalytic dihydroorotase-like protein [Pseudomonas
aeruginosa]
Length = 423
Score = 93.2 bits (228), Expect = 5e-18
Identities = 102/377 (27%), Positives = 166/377 (43%), Gaps = 41/377 (10%)
Query: 46 GKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKP----PVMDEKT 101
G + PGL+D+ V LR+ K +E+ T+AA GG T++ P T+P P + E
Sbjct: 50 GLVAAPGLVDLSVALREPGYGRKGNVESETRAAAAGGTTSLCCPPYTRPVLDTPAVAELI 109
Query: 102 LKMREFLFKKKSYADYAL--GF-------LLAGNEPVKADFYKIFMGASTGGIYSKNFEE 152
L K Y AL GF L+A + F G ++ I + E
Sbjct: 110 LDRAREAGNAKVYPIGALTRGFGGEQLSELVALRDTGCVAFTNGLHGFASNRILRRALE- 168
Query: 153 DYAKALDITSVH-AEDYELIS-----KYPER--------PPIVEISAIKKALNAARKVKK 198
YA D+T + ++D +L + P P E A+ + L +
Sbjct: 169 -YAATFDLTVIFTSQDTDLAEGGLAHEGPTASFLGLAGIPETAETVALARNLLLVEQSGV 227
Query: 199 PLHICHVSTREGLKEILEA---NIPWVSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDES 254
H +++ G++ + +A +P V+ +V + L LT + S L V PPLR +
Sbjct: 228 RAHFSQLTSARGIELVAQAQARGLP-VTCDVALYQLILTDEALVGFSSLYHVQPPLRTRA 286
Query: 255 DRRYLWEKLDN--VPIIASDHAPHTLEDKERGAA----GLPGLETEVALLLDAVNRGMLE 308
DR L E + N V IAS H PH + K A G+ G E + L + V G+L+
Sbjct: 287 DREALREAVKNGVVQAIASHHQPHEADAKNAPFAATEPGISGAELLLPLAMTLVQDGLLD 346
Query: 309 LWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWK 368
L ++ ++S PA+ R+ G+ AD + D + T+ E +Y+K +P+ G
Sbjct: 347 LPTLLARLSHGPAQALRLPAGRLAVGQAADLVLFDPQGS-TLAGESWYSKGQNSPFVGHC 405
Query: 369 VRGKVIMTILRGEIVME 385
+ G+V T++ G + E
Sbjct: 406 LPGRVRYTLVDGHLTHE 422
>gb|AAD09129.1| (AF112473) PyrABCN [Aspergillus nidulans]
Length = 2275
Score = 91.7 bits (224), Expect = 1e-17
Identities = 85/354 (24%), Positives = 160/354 (45%), Gaps = 46/354 (12%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMP-NTKPPVMDEKTLKMRE 106
IILPGLI+V + + E TKA++ G + + MP + D +TLK+ +
Sbjct: 1545 IILPGLINVGAFVPGLGSADSKDFEAVTKASIAAGFSMIRVMPVGVDSSITDARTLKLVQ 1604
Query: 107 FLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYS-----KNFEEDYAKALDIT 161
K S+ DY + + + +G TG + S + + +K +T
Sbjct: 1605 QNAGKASFCDYNFSVVATSSNSAE-------VGQLTGEVGSLFIPFNHLSGNISKVAAVT 1657
Query: 162 SVHAEDYELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTRE--GLKEILE 216
S +P PI+ + + + L A + +H+ V+++E GL + +
Sbjct: 1658 S-------HFGAWPSSKPIITDAKSTDLASVLLLASLHSRNIHVMSVTSKEDIGLIALSK 1710
Query: 217 ANIPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPH 276
V+ +V+ + LFL+R DY ++ L P R+ D++ LWE L + I + P+
Sbjct: 1711 EKGLKVTCDVSIYCLFLSRDDYPEAAFL----PTRE--DQKALWEHLSTIDIFSIGSIPY 1764
Query: 277 TLEDKERGAAGLPGLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKD 336
L ++ A G+ + LL AV+ G L + D++ ++ NP +IF + ++
Sbjct: 1765 QLAGEKGSPAA--GIAEALPLLFTAVSEGRLTVEDIIARLYENPKKIFELHDQ------- 1815
Query: 337 ADFAI-VDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
+D ++ V++ + + F + W+P+ G V+G V I +G+ D E+
Sbjct: 1816 SDSSVEVEIDRPYL-----FQSAQAWSPFSGKSVKGLVQRVIFQGKTSCLDSEI 1864
>sp|Q51551|PYRX_PSEAE DIHYDROOROTASE-LIKE PROTEIN (ASPARTATE CARBAMOYLTRANSFERASE 44 KDA
NON-CATALYTIC CHAIN) >gi|309886|gb|AAA25977.1| (L19649)
dihydroorotase-like [Pseudomonas aeruginosa]
Length = 423
Score = 90.1 bits (220), Expect = 4e-17
Identities = 101/377 (26%), Positives = 166/377 (43%), Gaps = 41/377 (10%)
Query: 46 GKIILPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKP----PVMDEKT 101
G + GL+D+ V LR+ K +E+ T+AA GG T++ P T+P P + E
Sbjct: 50 GLVAAAGLVDLSVALREPGYGRKGNVESETRAAAAGGTTSLCCPPYTRPVLDTPAVAELI 109
Query: 102 LKMREFLFKKKSYADYAL--GF-------LLAGNEPVKADFYKIFMGASTGGIYSKNFEE 152
L K Y AL GF L+A + F G ++ I + E
Sbjct: 110 LDRAREAGNAKVYPIGALTRGFGGEQLSELVALRDTGCVAFTNGLHGFASNRILRRALE- 168
Query: 153 DYAKALDITSVH-AEDYELIS-----KYPER--------PPIVEISAIKKALNAARKVKK 198
YA D+T + ++D +L + P P E A+ + L +
Sbjct: 169 -YAATFDLTVIFTSQDTDLAEGGLAHEGPTASFLGLAGIPETAETVALARNLLLVEQSGV 227
Query: 199 PLHICHVSTREGLKEILEA---NIPWVSFEVTPHHLFLTRKDYEK-SKLLKVYPPLRDES 254
H +++ G++ + +A +P V+ +V + L LT + S L V PPLR +
Sbjct: 228 RAHFSQLTSARGIELVAQAQARGLP-VTCDVALYQLILTDEALVGFSSLYHVQPPLRTRA 286
Query: 255 DRRYLWEKLDN--VPIIASDHAPHTLEDKERGAA----GLPGLETEVALLLDAVNRGMLE 308
DR L E ++N V IAS H PH + K A G+ G E + L + V G+L+
Sbjct: 287 DREALREAVNNGVVQAIASHHQPHEPDAKNAPFAATEPGISGAELLLPLAMTLVQDGLLD 346
Query: 309 LWDVVEKMSLNPARIFRIKNKGWGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGWK 368
L ++ ++S PA+ R+ G+ AD + D + T+ E +Y+K +P+ G
Sbjct: 347 LPTLLARLSHGPAQALRLPAGRLAVGQAADLVLFDPQGS-TLAGESWYSKGQNSPFVGHC 405
Query: 369 VRGKVIMTILRGEIVME 385
+ G+V T++ G + E
Sbjct: 406 LPGRVRYTLVDGHLTHE 422
>gb|AAD18071.1| (AF129814) carbamyl phosphate synthetase II; CPS.B domain
[Drosophila melanogaster]
Length = 752
Score = 86.6 bits (211), Expect = 5e-16
Identities = 60/171 (35%), Positives = 88/171 (51%), Gaps = 10/171 (5%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLF 109
LPG IDVHVHLR+ THKE +GT AA+ GG+T V MPNT P ++D +T + L
Sbjct: 582 LPGFIDVHVHLREPGATHKEDFASGTAAALAGGVTLVCAMPNTNPSIVDRETFTQFQELA 641
Query: 110 KKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDYE 169
K + DYAL + ++ A ++ A +Y N K D+TS
Sbjct: 642 KAGARCDYAL--YVGASDDNWAQVNELASHACGLKMY-LNDTFGTLKLSDMTSWQRH--- 695
Query: 170 LISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA 217
+S +P+R PIV E + + A + + +HICHV+ +E ++ I A
Sbjct: 696 -LSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSA 745
>sp|Q09794|PYR1_SCHPO URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ]
>gi|2130327|pir||S62450 hypothetical protein SPAC22G7.06c
- fission yeast (Schizosaccharomyces pombe)
>gi|7436765|pir||T11616 carbamoyl-phosphate synthase
(glutamine-hydrolyzing) (EC 6.3.5.5) - fission yeast
(Schizosaccharomyces pombe) >gi|1009456|emb|CAA91130.1|
(Z54328) ura1 protein contains: glutamine-dependent
carbamoyl-phosphatesynthase [Schizosaccharomyces pombe]
Length = 2244
Score = 85.0 bits (207), Expect = 1e-15
Identities = 90/348 (25%), Positives = 151/348 (42%), Gaps = 39/348 (11%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMP-NTKPPVMDEKTLKMREFL 108
LPGLI++ L +F E + TK + G T +P +T + D+ +L + L
Sbjct: 1539 LPGLINISAFLPEFTS---EAVSDYTKECIASGFTMARFLPFSTSSTLADKDSLSAVKKL 1595
Query: 109 FKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDY 168
++ DY + + V I S G +FE+D + +T+V +
Sbjct: 1596 ALDHAHCDYNFSVIASSTNEVT-----ISELTSESGCLFFHFEKDDSGIDHVTAVASH-- 1648
Query: 169 ELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWV 222
+ +P+ ++ + + + L A + +HI +VS+++ L I+ A ++P V
Sbjct: 1649 --FNVWPDTQTVMTDAKSTTLASLLLLASLHNRRIHITNVSSKDDLNLIVLAKQRSLP-V 1705
Query: 223 SFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKE 282
+F+V+ + LFL + DY + L P D D+ +W KL + + P L
Sbjct: 1706 TFDVSVYSLFLNQNDYPGATFL----PTAD--DQVEIWNKLSYIDCFSIGSIPSRLAKFV 1759
Query: 283 RGAAGLP-GLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAI 341
A G+ + LLL AVN G L L DVV++ NP IFR+ ++ G +
Sbjct: 1760 GNTAFTGFGVREAIPLLLTAVNEGRLTLKDVVDRFYSNPKAIFRLHDQD-DSGVQLE--- 1815
Query: 342 VDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
VD W+ K WTP+ G K+ G + G V D E+
Sbjct: 1816 VDRSVSWSSK--------DWTPFNGKKLYGSIQSVQFDGHDVFFDGEL 1855
>pir||S65074 pyrimidine synthesis protein URA1 - fission yeast
(Schizosaccharomyces pombe) >gi|1154952|emb|CAA57433.1|
(X81841) carbamoyl-phosphate synthase
(glutamine-hydrolysing) [Schizosaccharomyces pombe]
Length = 2223
Score = 85.0 bits (207), Expect = 1e-15
Identities = 90/348 (25%), Positives = 151/348 (42%), Gaps = 39/348 (11%)
Query: 50 LPGLIDVHVHLRDFNETHKETIETGTKAAVHGGITTVFDMP-NTKPPVMDEKTLKMREFL 108
LPGLI++ L +F E + TK + G T +P +T + D+ +L + L
Sbjct: 1518 LPGLINISAFLPEFTS---EAVSDYTKECIASGFTMARFLPFSTSSTLADKDSLSAVKKL 1574
Query: 109 FKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSVHAEDY 168
++ DY + + V I S G +FE+D + +T+V +
Sbjct: 1575 ALDHAHCDYNFSVIASSTNEVT-----ISELTSESGCLFFHFEKDDSGIDHVTAVASH-- 1627
Query: 169 ELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEILEA---NIPWV 222
+ +P+ ++ + + + L A + +HI +VS+++ L I+ A ++P V
Sbjct: 1628 --FNVWPDTQTVMTDAKSTTLASLLLLASLHNRRIHITNVSSKDDLNLIVLAKQRSLP-V 1684
Query: 223 SFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTLEDKE 282
+F+V+ + LFL + DY + L P D D+ +W KL + + P L
Sbjct: 1685 TFDVSVYSLFLNQNDYPGATFL----PTAD--DQVEIWNKLSYIDCFSIGSIPSRLAKFV 1738
Query: 283 RGAAGLP-GLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDADFAI 341
A G+ + LLL AVN G L L DVV++ NP IFR+ ++ G +
Sbjct: 1739 GNTAFTGFGVREAIPLLLTAVNEGRLTLKDVVDRFYSNPKAIFRLHDQD-DSGVQLE--- 1794
Query: 342 VDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
VD W+ K WTP+ G K+ G + G V D E+
Sbjct: 1795 VDRSVSWSSK--------DWTPFNGKKLYGSIQSVQFDGHDVFFDGEL 1834
>emb|CAB95124.1| (AJ251275) hypothetical protein [Homo sapiens]
Length = 564
Score = 81.1 bits (197), Expect = 2e-14
Identities = 114/444 (25%), Positives = 188/444 (41%), Gaps = 65/444 (14%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELK--GDNKIKVEKGKIILPGLIDV--HV 58
L+ GK + + + + +++G I + REL G K+ GK+++PG ID H
Sbjct: 11 LIKGGKVVNDDCTHEADVYIENGIIQQVG-RELMIPGGAKVIDATGKLVIPGGIDTSTHF 69
Query: 59 HLRDFNETHKETIETGTKAAVHGGITTVFD--MPNTKPPVMDEKTLKMREFLFKKKSYAD 116
H N T + GTKAA+ GG T + +P+ + ++D + L K D
Sbjct: 70 HQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVD--AYEKCRGLADPKVCCD 127
Query: 117 YALGFLLAGNEP-VKADF-----------YKIFMGASTGGIYSKNFEEDY-----AKALD 159
YAL + P VKA+ +++FM + +Y E Y K +
Sbjct: 128 YALHVGITWWAPKVKAEMETLVREKGVNSFQMFM--TYKDLYMLRDSELYQVLHACKDIG 185
Query: 160 -ITSVHAEDYELISKY-----------PE-----RPPIVEISAIKKALNAARKVKKPLHI 202
I VHAE+ EL+++ PE RP +E A + + A + P+++
Sbjct: 186 AIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYL 245
Query: 203 CHVSTREGLKEILEANIPW--VSFEVTPHHLFLT-----RKDYEKSKLLKVYPPLR-DES 254
+VS+ I A + V E T H LT +D+ + PPLR D +
Sbjct: 246 VNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTN 305
Query: 255 DRRYLWEKL--DNVPIIASDHAPHTLEDKERGAA-------GLPGLETEVALLLD-AVNR 304
YL L D + I+ASDH P T + K G G+ G++ ++++ + V
Sbjct: 306 TSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVG 365
Query: 305 GMLELWDVVEKMSLNPARIFRIKNKGWG--EGKDADFAIVDMKKEWTIKAEEFYTKAGWT 362
G ++ V S + A++ + + G DAD + D + TI A +
Sbjct: 366 GKMDENRFVAVTSSSAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFN 425
Query: 363 PYEGWKVRGKVIMTILRGEIVMED 386
YE + G ++TI RG +V E+
Sbjct: 426 LYENMRCHGVPLVTISRGRVVYEN 449
>emb|CAA69153.1| (Y07818) ULIP [Homo sapiens]
Length = 570
Score = 79.6 bits (193), Expect = 6e-14
Identities = 110/442 (24%), Positives = 188/442 (41%), Gaps = 61/442 (13%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLREL-KGDNKIKVEKGKIILPGLIDVHVHLR 61
L+ G+ + + + I ++DG I + + G K GK+++PG IDVH H +
Sbjct: 18 LIKGGRIVNDDQSFYADIYMEDGLIKQIGDNVIVPGGVKTIEANGKMVIPGGIDVHTHFQ 77
Query: 62 DFNE--THKETIETGTKAAVHGGITTVFDMPNTKPPV-MDEKTLKMREFLFKKKSYADYA 118
+ T + GTKAA+ GG T + D +P + E K RE+ KS DYA
Sbjct: 78 MPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWA-DGKSCCDYA 136
Query: 119 LGFLLAG-NEPVKADFYKIFMGASTGG---------IYSKNFEEDY------AKALDITS 162
L +A N+ VK + + +Y + E Y + I
Sbjct: 137 LHVDIAHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQ 196
Query: 163 VHAEDYELISKY-----------PE-----RPPIVEISAIKKALNAARKVKKPLHICHVS 206
VHAE+ ++I++ PE RP +E A+ +A+ A + PL++ V
Sbjct: 197 VHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKVM 256
Query: 207 TREGLKEILEA----NIPW-----VSFEVTPHHLFLTRKDYEKSKLLKVYPPLR-DESDR 256
++ I +A N+ + S + H + K++ K+ PPL D +
Sbjct: 257 SKSAADLISQARKKGNVVFGEPITASLGIDGTHYW--SKNWAKAAAFVTSPPLSPDPTTP 314
Query: 257 RYLWEKL--DNVPIIASDHAPHTLEDKERGA-------AGLPGLETEVALLLD-AVNRGM 306
Y+ L ++ + S H + K G G G+E ++++ D AV G
Sbjct: 315 DYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGK 374
Query: 307 LELWDVVEKMSLNPARIFRI-KNKGW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPY 364
++ V S N A+IF + KG G D+D I D + A+ + A + +
Sbjct: 375 MDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEYNIF 434
Query: 365 EGWKVRGKVIMTILRGEIVMED 386
EG ++RG ++ I +G+I++ED
Sbjct: 435 EGMELRGAPLVVICQGKIMLED 456
>gi|9910168 collapsin response mediator protein-5; CRMP3-associated molecule
[Homo sapiens] >gi|8886025|gb|AAF80348.1|AF157634_1
(AF157634) collapsin response mediator protein-5 [Homo
sapiens]
Length = 564
Score = 79.2 bits (192), Expect = 8e-14
Identities = 113/444 (25%), Positives = 187/444 (41%), Gaps = 65/444 (14%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELK--GDNKIKVEKGKIILPGLIDV--HV 58
L+ GK + + + + +++G I + REL G K+ GK+++PG ID H
Sbjct: 11 LIKGGKVVNDDCTHEADVYIENGIIQQVG-RELMIPGGAKVIDATGKLVIPGGIDTSTHF 69
Query: 59 HLRDFNETHKETIETGTKAAVHGGITTVFD--MPNTKPPVMDEKTLKMREFLFKKKSYAD 116
H N T + GTKAA+ GG T + +P+ + ++D + L K D
Sbjct: 70 HQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVD--AYEKCRGLADPKVCCD 127
Query: 117 YALGFLLAGNEP-VKADF-----------YKIFMGASTGGIYSKNFEEDY-----AKALD 159
YAL + P VKA+ +++FM + +Y E Y K +
Sbjct: 128 YALHVGITWWAPKVKAEMETLVREKGVNSFQMFM--TYKDLYMLRDSELYQVLHACKDIG 185
Query: 160 -ITSVHAEDYELISKY-----------PE-----RPPIVEISAIKKALNAARKVKKPLHI 202
I VHAE+ EL+++ PE RP +E A + + A + P+++
Sbjct: 186 AIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYL 245
Query: 203 CHVSTREGLKEILEANIPW--VSFEVTPHHLFLT-----RKDYEKSKLLKVYPPLR-DES 254
+VS+ I A + V E T H LT +D+ + PPLR D +
Sbjct: 246 VNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTN 305
Query: 255 DRRYLWEKL--DNVPIIASDHAPHTLEDKERGAA-------GLPGLETEVALLLD-AVNR 304
YL L D + I+ASDH P T + K G G+ G++ ++++ + V
Sbjct: 306 TSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVG 365
Query: 305 GMLELWDVVEKMSLNPARIFRIKNKGWG--EGKDADFAIVDMKKEWTIKAEEFYTKAGWT 362
G ++ V S N +++ + + G AD + D + TI A +
Sbjct: 366 GKMDENRFVAVTSSNASKLLNLYPRKGRIIPGAHADVVVWDPEATKTISASTQVQGGDFN 425
Query: 363 PYEGWKVRGKVIMTILRGEIVMED 386
YE + G ++TI RG +V E+
Sbjct: 426 LYENMRCHGVPLVTISRGRVVYEN 449
>gb|AAG37998.1|AF249295_1 (AF249295) collapsin response mediator protein 5 [Mus musculus]
Length = 564
Score = 78.8 bits (191), Expect = 1e-13
Identities = 112/442 (25%), Positives = 179/442 (40%), Gaps = 61/442 (13%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLRELK--GDNKIKVEKGKIILPGLIDV--HV 58
L+ GK + + + + ++ G I + REL G K+ GK+++PG ID H
Sbjct: 11 LIKGGKVVNDDCTHEADVYIESGIIQQVG-RELMIPGGAKVIDATGKLVIPGGIDTSTHF 69
Query: 59 HLRDFNETHKETIETGTKAAVHGGITTVFD--MPNTKPPVMDEKTLKMREFLFKKKSYAD 116
H N T + GTKAA+ GG T + +P+ + +++ + L K D
Sbjct: 70 HQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVE--AYEKCRALADPKVCCD 127
Query: 117 YALGFLLAGNEP-VKADFYKIFMGASTGGIYSKNFEEDYAKALD---------------I 160
YAL + P VKA+ + +D D I
Sbjct: 128 YALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVFHACRDIGAI 187
Query: 161 TSVHAEDYELISK-----------YPE-----RPPIVEISAIKKALNAARKVKKPLHICH 204
VHAE+ EL+++ PE P +E A + + A + P+++ +
Sbjct: 188 PRVHAENGELVAEGAKEALDLGITGPEGIEISHPEELEAEATHRVITIANRTHCPIYLVN 247
Query: 205 VSTREGLKEILEANIPW--VSFEVTPHHLFLT-----RKDYEKSKLLKVYPPLR-DESDR 256
VS+ I A + V E T H LT +D+ + PPLR D +
Sbjct: 248 VSSISAGDVIAAAKMQGKVVLAETTNAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTS 307
Query: 257 RYLWEKL--DNVPIIASDHAPHTLEDKERGAA-------GLPGLETEVALLLD-AVNRGM 306
YL L D + I+ASDH P T + K G G+ G++ ++++ + V G
Sbjct: 308 TYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVVWERGVVGGK 367
Query: 307 LELWDVVEKMSLNPARIFRI-KNKG-WGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPY 364
++ V S N A+I + KG G DAD + D + TI A + Y
Sbjct: 368 MDENRFVAVTSSNAAKILNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLY 427
Query: 365 EGWKVRGKVIMTILRGEIVMED 386
E + G ++TI RG +V E+
Sbjct: 428 ENMRCHGVPLVTISRGRVVYEN 449
>gi|4503379 dihydropyrimidinase-like 3 [Homo sapiens]
>gi|3122050|sp|Q14195|DPY3_HUMAN DIHYDROPYRIMIDINASE
RELATED PROTEIN-3 (DRP-3) (UNC-33-LIKE PHOSPHOPROTEIN)
(ULIP PROTEIN) >gi|7512387|pir||JC5318
dihydropyrimidinase related protein 3 - human
>gi|1330242|dbj|BAA11192.1| (D78014) dihydropyrimidinase
related protein-3 [Homo sapiens]
Length = 570
Score = 78.0 bits (189), Expect = 2e-13
Identities = 109/442 (24%), Positives = 187/442 (41%), Gaps = 61/442 (13%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLREL-KGDNKIKVEKGKIILPGLIDVHVHLR 61
L+ G+ + + + I ++DG I + + G K GK+++PG IDVH H +
Sbjct: 18 LIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQ 77
Query: 62 DFNE--THKETIETGTKAAVHGGITTVFDMPNTKPPV-MDEKTLKMREFLFKKKSYADYA 118
+ T + GTKAA+ GG T + D +P + E K RE+ KS DYA
Sbjct: 78 MPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWA-DGKSCCDYA 136
Query: 119 LGF-LLAGNEPVKADFYKIFMGASTGG---------IYSKNFEEDY------AKALDITS 162
L + N+ VK + + +Y + E Y + I
Sbjct: 137 LHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQ 196
Query: 163 VHAEDYELISKY-----------PE-----RPPIVEISAIKKALNAARKVKKPLHICHVS 206
VHAE+ ++I++ PE RP +E A+ +A+ A + PL++ V
Sbjct: 197 VHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKVM 256
Query: 207 TREGLKEILEA----NIPW-----VSFEVTPHHLFLTRKDYEKSKLLKVYPPLR-DESDR 256
++ I +A N+ + S + H + K++ K+ PPL D +
Sbjct: 257 SKSAADLISQARKKGNVVFGEPITASLGIDGTHYW--SKNWAKAAAFVTSPPLSPDPTTP 314
Query: 257 RYLWEKL--DNVPIIASDHAPHTLEDKERGA-------AGLPGLETEVALLLD-AVNRGM 306
Y+ L ++ + S H + K G G G+E ++++ D AV G
Sbjct: 315 DYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGK 374
Query: 307 LELWDVVEKMSLNPARIFRI-KNKGW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPY 364
++ V S N A+IF + KG G D+D I D + A+ + A + +
Sbjct: 375 MDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEYNIF 434
Query: 365 EGWKVRGKVIMTILRGEIVMED 386
EG ++RG ++ I +G+I++ED
Sbjct: 435 EGMELRGAPLVVICQGKIMLED 456
>gi|4503375 dihydropyrimidinase [Homo sapiens] >gi|3122049|sp|Q14117|DPYS_HUMAN
DIHYDROPYRIMIDINASE (DHPASE) (HYDANTOINASE) (DHP)
>gi|7512385|pir||JC5315 dihydropyrimidinase (EC 3.5.2.2)
- human >gi|1330236|dbj|BAA11189.1| (D78011)
dihydropyrimidinase [Homo sapiens]
>gi|3608122|dbj|BAA33067.1| (AB004678)
dihydropyrimidinase [Homo sapiens]
Length = 519
Score = 77.6 bits (188), Expect = 2e-13
Identities = 103/405 (25%), Positives = 170/405 (41%), Gaps = 76/405 (18%)
Query: 46 GKIILPGLIDVHVHL-------RDFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMD 98
GK++LPG ID H H+ R ++ H+ GTKAA+ GG T + D +
Sbjct: 56 GKLVLPGGIDTHTHMQFPFMGSRSIDDFHQ-----GTKAALSGGTTMIIDF------AIP 104
Query: 99 EKTLKMREFLFKKKSYA------DYALGFLLA-GNEPVKADF-----------YKIFMG- 139
+K + E +S+A DY+L + ++ VK + +K+FM
Sbjct: 105 QKGGSLIEAFETWRSWADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAY 164
Query: 140 ASTGGIYSKNFEEDYAKALD---ITSVHAEDYELISK-----------YPE-----RPPI 180
+ E +++ + I VHAE+ +LI++ PE RP
Sbjct: 165 KDLYMVTDLELYEAFSRCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEA 224
Query: 181 VEISAIKKALNAARKVKKPLHICHVSTREGLKEILEANIPW-------VSFEVTPHHLFL 233
VE A +A+ A V PL+I HV ++ K I +A ++ +
Sbjct: 225 VEAEATLRAITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHY 284
Query: 234 TRKDYEKSKLLKVYPPLR-DESDRRYLWEKL--DNVPIIASDHAPHTLEDKERG------ 284
K++ + + PPLR D S +L L D++ +D+ K G
Sbjct: 285 WNKEWHHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTK 344
Query: 285 -AAGLPGLETEVALLLD-AVNRGMLELWDVVEKMSLNPARIFRI-KNKG-WGEGKDADFA 340
G+ G+E ++++ + V+ G ++ V S N A+IF + KG G DAD
Sbjct: 345 IPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIV 404
Query: 341 IVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVME 385
I D K TI A+ + + +EG G ++TI RG++V E
Sbjct: 405 IWDPKGTRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYE 449
>sp|Q63150|DPYS_RAT DIHYDROPYRIMIDINASE (DHPASE) (HYDANTOINASE) (DHP)
>gi|2143701|pir||S70581 dihydropyrimidinase - rat
>gi|1378019|dbj|BAA09833.1| (D63704) dihydropyrimidinase
[Rattus norvegicus]
Length = 519
Score = 76.9 bits (186), Expect = 4e-13
Identities = 101/396 (25%), Positives = 158/396 (39%), Gaps = 58/396 (14%)
Query: 46 GKIILPGLIDVHVHLRD--FNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLK 103
GK++LPG ID H H++ + GTKAA+ GG T + D + + +
Sbjct: 56 GKLVLPGGIDTHTHMQFPFMGSQSVDDFHQGTKAALAGGTTMIIDFAIPQKGSSLIEAFE 115
Query: 104 MREFLFKKKSYADYALGFLLAG-NEPVKADF-----------YKIFMGASTGGIYSKNFE 151
K DY+L + ++ VK + +K+FM +Y +
Sbjct: 116 TWRNWADPKVCCDYSLHVAVTWWSDKVKEEMKTLAQDKGVNSFKMFMAYKD--LYMVQDQ 173
Query: 152 EDYAKALD------ITSVHAEDYELISKY-----------PE-----RPPIVEISAIKKA 189
+ YA I VHAE+ +LI++ PE RP VE A +A
Sbjct: 174 QMYAAFSQCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRA 233
Query: 190 LNAARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLT-------RKDYEKSK 242
+ A V PL+I HV ++ K I +A P L K++ +
Sbjct: 234 ITIASAVNCPLYIVHVMSKSAAKVIADAKREGKVVYGEPIAAGLGTDGTQYWNKEWRHAA 293
Query: 243 LLKVYPPLR-DESDRRYLWEKLDN--VPIIASDHAPHTLEDKERGAA-------GLPGLE 292
+ PPLR D S +L L N + SD+ K G G+ G+E
Sbjct: 294 HHVMGPPLRPDPSTPGFLMNLLANGDLTTTGSDNCTFNTCQKALGKDDFTKIPNGVNGVE 353
Query: 293 TEVALLLD-AVNRGMLELWDVVEKMSLNPARIFRI--KNKGWGEGKDADFAIVDMKKEWT 349
++++ + V+ G ++ V S N A+IF + K G DAD I D + T
Sbjct: 354 DRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPKKGRIAVGSDADMVIWDPEATRT 413
Query: 350 IKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVME 385
I A+ + + +EG G ++TI RG +V E
Sbjct: 414 ISAKTHHQAVNFNIFEGMVCHGVPLVTISRGRVVYE 449
>gi|6681219 dihydropyrimidinase-like 3; unc-33-like phosphoprotein [Mus
musculus] >gi|3122052|sp|Q62188|DPY3_MOUSE
DIHYDROPYRIMIDINASE RELATED PROTEIN-3 (DRP-3)
(UNC-33-LIKE PHOSPHOPROTEIN) (ULIP PROTEIN)
>gi|1083556|pir||S55525 Ulip protein - mouse
>gi|861059|emb|CAA61082.1| (X87817) Ulip [Mus musculus]
Length = 570
Score = 76.5 bits (185), Expect = 5e-13
Identities = 109/442 (24%), Positives = 187/442 (41%), Gaps = 61/442 (13%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLREL-KGDNKIKVEKGKIILPGLIDVHVHLR 61
L+ G+ + + + I ++DG I + + G K GK+++PG IDVH H +
Sbjct: 18 LIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQ 77
Query: 62 DFNE--THKETIETGTKAAVHGGITTVFDMPNTKPPV-MDEKTLKMREFLFKKKSYADYA 118
+ T + GTKAA+ GG T + D +P + E K RE+ KS DYA
Sbjct: 78 MPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWA-DGKSCCDYA 136
Query: 119 LGF-LLAGNEPVKADFYKIFMGASTGG---------IYSKNFEEDY------AKALDITS 162
L + N+ VK + + +Y + E Y + I
Sbjct: 137 LHVDITHWNDSVKQEVQSLSKEKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQ 196
Query: 163 VHAEDYELISKY-----------PE-----RPPIVEISAIKKALNAARKVKKPLHICHVS 206
VHAE+ ++I++ PE RP +E A+ +A+ A + PL++ V
Sbjct: 197 VHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVM 256
Query: 207 TREGLKEILEA----NIPW-----VSFEVTPHHLFLTRKDYEKSKLLKVYPPLR-DESDR 256
++ I +A N+ + S + H + K++ K+ PPL D +
Sbjct: 257 SKSAADLISQARKKGNVVFGEPITASLGIDGTHYW--SKNWAKAAAFVTSPPLSPDPTTP 314
Query: 257 RYLWEKL--DNVPIIASDHAPHTLEDKERGA-------AGLPGLETEVALLLD-AVNRGM 306
Y+ L ++ + S H + K G G G+E ++++ D AV G
Sbjct: 315 DYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGK 374
Query: 307 LELWDVVEKMSLNPARIFRI-KNKGW-GEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPY 364
++ V S N A+IF + KG G D+D I D + A+ + A + +
Sbjct: 375 MDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDALKIVSAKNHQSVAEYNIF 434
Query: 365 EGWKVRGKVIMTILRGEIVMED 386
EG ++RG ++ I +G+I++ED
Sbjct: 435 EGMELRGAPLVVICQGKIMLED 456
>gi|11416486 dihydropyrimidinase-like 3 [Homo sapiens]
Length = 532
Score = 76.5 bits (185), Expect = 5e-13
Identities = 101/398 (25%), Positives = 170/398 (42%), Gaps = 60/398 (15%)
Query: 46 GKIILPGLIDVHVHLRDFNE--THKETIETGTKAAVHGGITTVFDMPNTKPPV-MDEKTL 102
GK+++PG IDVH H + + T + GTKAA+ GG T + D +P + E
Sbjct: 24 GKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYE 83
Query: 103 KMREFLFKKKSYADYALGF-LLAGNEPVKADFYKIFMGASTGG---------IYSKNFEE 152
K RE+ KS DYAL + N+ VK + + +Y + E
Sbjct: 84 KWREWA-DGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE 142
Query: 153 DY------AKALDITSVHAEDYELISKY-----------PE-----RPPIVEISAIKKAL 190
Y + I VHAE+ ++I++ PE RP +E A+ +A+
Sbjct: 143 LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI 202
Query: 191 NAARKVKKPLHICHVSTREGLKEILEA----NIPW-----VSFEVTPHHLFLTRKDYEKS 241
A + PL++ V ++ I +A N+ + S + H + K++ K+
Sbjct: 203 TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYW--SKNWAKA 260
Query: 242 KLLKVYPPLR-DESDRRYLWEKL--DNVPIIASDHAPHTLEDKERGA-------AGLPGL 291
PPL D + Y+ L ++ + S H + K G G G+
Sbjct: 261 AAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGV 320
Query: 292 ETEVALLLD-AVNRGMLELWDVVEKMSLNPARIFRI-KNKGW-GEGKDADFAIVDMKKEW 348
E ++++ D AV G ++ V S N A+IF + KG G D+D I D
Sbjct: 321 EERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVK 380
Query: 349 TIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMED 386
+ A+ + A + +EG ++RG ++ I +G+I++ED
Sbjct: 381 IVSAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLED 418
>gb|AAF04317.1| (AF150928) dihydropyrimidinase homolog [Acinetobacter sp. ADP1]
Length = 136
Score = 74.1 bits (179), Expect = 3e-12
Identities = 39/101 (38%), Positives = 59/101 (57%), Gaps = 1/101 (0%)
Query: 22 VKDGKITKFSLRELKGDNKIKVE-KGKIILPGLIDVHVHLRDFNETHKETIETGTKAAVH 80
+K+G+I K +N ++E G+ +LPG+ID VH RD HK I + + AA
Sbjct: 29 IKNGRIAKIQSSISSINNAKEIEANGRWLLPGMIDDQVHFRDPGSPHKGCIASESAAATI 88
Query: 81 GGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYALGF 121
GGIT+ DMPNT+PP +D L+ ++ + + S A+YA F
Sbjct: 89 GGITSYMDMPNTQPPTLDLDALQAKKTIASQTSIANYAFHF 129
>gb|AAA35198.1| (J04711) carbamylase phosphate synthetase-aspartate
transcarbamylase (EC 2.1.3.2) [Saccharomyces cerevisiae]
Length = 947
Score = 73.7 bits (178), Expect = 3e-12
Identities = 81/353 (22%), Positives = 151/353 (41%), Gaps = 43/353 (12%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETG--TKAAVHGGITTVFDMPNT--KPPVMDEKTLK 103
I LPGLI++ ++ + + K E T+ + G T MP + P + D +LK
Sbjct: 237 ITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLK 296
Query: 104 MREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSV 163
+ + SY D++ F +AG +K G + F IT+V
Sbjct: 297 AANSVSQDSSYTDFS--FTMAGTA------HKAHSGTQAASKVTALFLPLRELKNKITAV 348
Query: 164 HAEDYELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEIL--EAN 218
EL++++P ++ + + + L + +HI VS +E L I+ +A
Sbjct: 349 A----ELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAK 404
Query: 219 IPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTL 278
P V+ +V + LF+ + DY ++ V+ P ++ D+ + W LD++ + P L
Sbjct: 405 DPRVTCDVNIYSLFIAQDDYPEA----VFLPTKE--DQEFFWNNLDSIDAFSVGALPVAL 458
Query: 279 EDKERGAAGLP-GLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDA 337
+ + G++ + LLL AV G L + D+V ++ NPA+IF I + D
Sbjct: 459 ANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDL 518
Query: 338 DFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVI 390
D++ F W+P+ + G + + GE ++ E++
Sbjct: 519 DYS--------------FRRNKRWSPFNK-DMNGGIERVVYNGETLVLSGELV 556
>sp|Q90635|DPY2_CHICK DIHYDROPYRIMIDINASE RELATED PROTEIN-2 (DRP-2) (COLLAPSIN RESPONSE
MEDIATOR PROTEIN CRMP-62) >gi|2134319|pir||S58889
collapsin response mediator protein, 62K - chicken
>gi|882147|gb|AAA93200.1| (U17277) CRMP-62 [Gallus
gallus] >gi|1582081|prf||2117410A collapsin response
mediator protein:ISOTYPE=CRMP-62 [Gallus gallus]
Length = 572
Score = 73.4 bits (177), Expect = 5e-12
Identities = 101/439 (23%), Positives = 172/439 (39%), Gaps = 55/439 (12%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKFSLREL-KGDNKIKVEKGKIILPGLIDVHVHLR 61
L+ GK + + + I ++DG I + + G K G++++PG IDVH +
Sbjct: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHGRMVIPGGIDVHTRFQ 77
Query: 62 --DFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYADYAL 119
+ T + GTKAA+ GG T + D +P KS DY+L
Sbjct: 78 MPEQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLTAFDQWREWADSKSCCDYSL 137
Query: 120 GF-LLAGNEPVKADFYKIFMGASTGGI-----YSKNFEEDYAKALDITS----------V 163
+ ++ V+ + + + F+ ++ ++ S V
Sbjct: 138 HVDITEWHKGVQEEMEALVKDHGVNSFLVYMAFKDRFQLSDSQIYEVLSVIRDIGATAQV 197
Query: 164 HAEDYELISKYPE----------------RPPIVEISAIKKALNAARKVKKPLHICHVST 207
HAE+ ++I++ + RP VE A+ +A+ A + PL+I V +
Sbjct: 198 HAENGDIIAEEQQRILELGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMS 257
Query: 208 REGLKEILEANIPWVSFEVTPHHLFL-------TRKDYEKSKLLKVYPPLR-DESDRRYL 259
+ + I +A P L K++ K+ PPL D + +L
Sbjct: 258 KSAAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317
Query: 260 WEKLD--NVPIIASDHAPHTLEDKERG-------AAGLPGLETEVALLLD-AVNRGMLEL 309
L ++ + S H K G G G E ++++ D AV G ++
Sbjct: 318 NSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSIIWDKAVVTGKMDE 377
Query: 310 WDVVEKMSLNPARIFRI-KNKG-WGEGKDADFAIVDMKKEWTIKAEEFYTKAGWTPYEGW 367
V S N A+IF + KG G DAD I D TI A+ + +EG
Sbjct: 378 NQFVAVTSTNAAKIFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNISLEYNIFEGM 437
Query: 368 KVRGKVIMTILRGEIVMED 386
+ RG ++ I +G+IV+ED
Sbjct: 438 ECRGSPLVVISQGKIVLED 456
>gb|AAA68280.1| (M27174) carbamyl phosphate synthetase [Saccharomyces cerevisiae]
Length = 2214
Score = 71.4 bits (172), Expect = 2e-11
Identities = 82/353 (23%), Positives = 153/353 (43%), Gaps = 43/353 (12%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETG--TKAAVHGGITTVFDMPNT--KPPVMDEKTLK 103
I LPGLI++ ++ + + K E T+ + G T MP + P + D +LK
Sbjct: 1505 ITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLK 1564
Query: 104 MREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSV 163
+ + SY D++ F +AG + + + AS E K IT+V
Sbjct: 1565 AANSVSQDSSYTDFS--FTIAGTAH---NAHSVTQSASKVTALFLPLRELKNK---ITAV 1616
Query: 164 HAEDYELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEIL--EAN 218
EL++++P ++ + + + L + +HI VS +E L I+ +A
Sbjct: 1617 A----ELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAK 1672
Query: 219 IPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTL 278
P V+ +V + LF+ + DY ++ V+ P ++ D+ + W LD++ + P L
Sbjct: 1673 DPRVTCDVNIYSLFIAQDDYPEA----VFLPTKE--DQEFFWNNLDSIDAFSVGALPVAL 1726
Query: 279 EDKERGAAGLP-GLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDA 337
+ + G++ + LLL AV G L + D+V ++ NPA+IF I + D
Sbjct: 1727 ANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDL 1786
Query: 338 DFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVI 390
D++ F W+P+ + G + + GE ++ E++
Sbjct: 1787 DYS--------------FRRNKRWSPFNK-DMNGGIERVVYNGETLVLSGELV 1824
>emb|CAA60825.1| (X87371) carbamyl phosphate synthetase [Saccharomyces cerevisiae]
Length = 2040
Score = 71.4 bits (172), Expect = 2e-11
Identities = 82/353 (23%), Positives = 153/353 (43%), Gaps = 43/353 (12%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETG--TKAAVHGGITTVFDMPNT--KPPVMDEKTLK 103
I LPGLI++ ++ + + K E T+ + G T MP + P + D +LK
Sbjct: 1331 ITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLK 1390
Query: 104 MREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSV 163
+ + SY D++ F +AG + + + AS E K IT+V
Sbjct: 1391 AANSVSQDSSYTDFS--FTIAGTAH---NAHSVTQSASKVTALFLPLRELKNK---ITAV 1442
Query: 164 HAEDYELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEIL--EAN 218
EL++++P ++ + + + L + +HI VS +E L I+ +A
Sbjct: 1443 A----ELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAK 1498
Query: 219 IPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTL 278
P V+ +V + LF+ + DY ++ V+ P ++ D+ + W LD++ + P L
Sbjct: 1499 DPRVTCDVNIYSLFIAQDDYPEA----VFLPTKE--DQEFFWNNLDSIDAFSVGALPVAL 1552
Query: 279 EDKERGAAGLP-GLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDA 337
+ + G++ + LLL AV G L + D+V ++ NPA+IF I + D
Sbjct: 1553 ANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDL 1612
Query: 338 DFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVI 390
D++ F W+P+ + G + + GE ++ E++
Sbjct: 1613 DYS--------------FRRNKRWSPFNK-DMNGGIERVVYNGETLVLSGELV 1650
>gi|6322331 carbamoyl-phophate synthetase, aspartate transcarbamylase, and
glutamine amidotransferase; Ura2p [Saccharomyces
cerevisiae] >gi|1172782|sp|P07259|PYR1_YEAST URA1 PROTEIN
[INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ]
>gi|1070511|pir||QZBYU2 pyrimidine synthesis protein URA2
- yeast (Saccharomyces cerevisiae)
>gi|1008332|emb|CAA89425.1| (Z49405) ORF YJL130c
[Saccharomyces cerevisiae]
Length = 2214
Score = 71.4 bits (172), Expect = 2e-11
Identities = 82/353 (23%), Positives = 153/353 (43%), Gaps = 43/353 (12%)
Query: 48 IILPGLIDVHVHLRDFNETHKETIETG--TKAAVHGGITTVFDMPNT--KPPVMDEKTLK 103
I LPGLI++ ++ + + K E T+ + G T MP + P + D +LK
Sbjct: 1505 ITLPGLINIATYVPNASHVIKGPAELKETTRLFLESGFTYCQLMPRSISGPVITDVASLK 1564
Query: 104 MREFLFKKKSYADYALGFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYAKALDITSV 163
+ + SY D++ F +AG + + + AS E K IT+V
Sbjct: 1565 AANSVSQDSSYTDFS--FTIAGTAH---NAHSVTQSASKVTALFLPLRELKNK---ITAV 1616
Query: 164 HAEDYELISKYPERPPIV---EISAIKKALNAARKVKKPLHICHVSTREGLKEIL--EAN 218
EL++++P ++ + + + L + +HI VS +E L I+ +A
Sbjct: 1617 A----ELLNQWPTEKQVIAEAKTADLASVLLLTSLQNRSIHITGVSNKEDLALIMTVKAK 1672
Query: 219 IPWVSFEVTPHHLFLTRKDYEKSKLLKVYPPLRDESDRRYLWEKLDNVPIIASDHAPHTL 278
P V+ +V + LF+ + DY ++ V+ P ++ D+ + W LD++ + P L
Sbjct: 1673 DPRVTCDVNIYSLFIAQDDYPEA----VFLPTKE--DQEFFWNNLDSIDAFSVGALPVAL 1726
Query: 279 EDKERGAAGLP-GLETEVALLLDAVNRGMLELWDVVEKMSLNPARIFRIKNKGWGEGKDA 337
+ + G++ + LLL AV G L + D+V ++ NPA+IF I + D
Sbjct: 1727 ANVTGNKVDVGMGIKDSLPLLLAAVEEGKLTIDDIVLRLHDNPAKIFNIPTQDSVVEIDL 1786
Query: 338 DFAIVDMKKEWTIKAEEFYTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEVI 390
D++ F W+P+ + G + + GE ++ E++
Sbjct: 1787 DYS--------------FRRNKRWSPFNK-DMNGGIERVVYNGETLVLSGELV 1824
>gb|AAD46840.1|AF160900_1 (AF160900) BcDNA.HL02693 [Drosophila melanogaster]
>gi|5813772|gb|AAD52007.1|AF077837_1 (AF077837)
collapsin response mediator protein [Drosophila
melanogaster] >gi|7296723|gb|AAF52002.1| (AE003602) CRMP
gene product [alt 1] [Drosophila melanogaster]
Length = 589
Score = 71.4 bits (172), Expect = 2e-11
Identities = 112/454 (24%), Positives = 182/454 (39%), Gaps = 86/454 (18%)
Query: 9 FLYNGRIID------GSIGVKDGKITKF----SLRELKGDNKIKVEKGKIILPGLIDVHV 58
++ NG I++ + ++DG I KF S + G + G +I+PG ID H
Sbjct: 23 YIKNGEIVNHDKSFKADVYIEDG-IIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHT 81
Query: 59 HLR--DFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTLKMREFLFKKKSYAD 116
H++ + GTKAAV GG T + D V+ K M E K +S+AD
Sbjct: 82 HMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDF------VLPNKHESMIEAYDKWRSWAD 135
Query: 117 ------YAL---------------GFLLAGNEPVKADFYKIFMGASTGGIYSKNFEEDYA 155
Y L G L + + + +K FM G+Y N + D
Sbjct: 136 PKVCCDYGLHVGITWWSKSVSEEIGILC---KELGVNSFKTFMAYK--GLYQLN-DSDLL 189
Query: 156 KALD-------ITSVHAEDYELISKYPER----------------PPIVEISAIKKALNA 192
+ + VHAE+ ++I+K +R P VE A+ +A
Sbjct: 190 DVFERIRHLNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVL 249
Query: 193 ARKVKKPLHICHVSTREGLKEILEANIPWVSFEVTPHHLFLTRKDYEKSKLLKVY----P 248
A ++K PL + ++++ + + A L R K ++Y P
Sbjct: 250 AHQMKTPLFVSGLTSKSSAELVGRARRSGYCVFGETLASSLGRSMSAVPKGDRIYAITSP 309
Query: 249 PLRDESDR-RYLWEKL--DNVPIIASDHAPHTLEDKERGAA-------GLPGLETEVALL 298
P+R+ ++ R L + L D++ + SD+ E K G G+ G+E ++L+
Sbjct: 310 PIRESAETPRQLMKSLAYDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLV 369
Query: 299 LD-AVNRGMLELWDVVEKMSLNPARIFRI-KNKGW-GEGKDADFAIVDMKKEWTIKAEEF 355
+ V+ G+L+ V S N A+IF I KG G DAD I + TI +
Sbjct: 370 WEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTH 429
Query: 356 YTKAGWTPYEGWKVRGKVIMTILRGEIVMEDDEV 389
+ + +EG V G ++RG I E V
Sbjct: 430 HHACDFNIFEGMTVHGVCEFVLVRGRICAERGNV 463
>sp|Q18677|DPY1_CAEEL HYPOTHETICAL 56.3 KD PROTEIN C47E12.8 IN CHROMOSOME IV
>gi|7497571|pir||T20007 hypothetical protein C47E12.8 -
Caenorhabditis elegans >gi|3875109|emb|CAA93104.1|
(Z68882) predicted using Genefinder~Similarity to Mouse
Ulip protein (PIR Acc. No. S55525), contains similarity
to Pfam domain: PF00744 (Dihydroorotase-like),
Score=252.4, E-value=2.1e-72, N=1 [Caenorhabditis
elegans]
Length = 520
Score = 69.1 bits (166), Expect = 9e-11
Identities = 107/448 (23%), Positives = 174/448 (37%), Gaps = 66/448 (14%)
Query: 3 LVLVGKFLYNGRIIDGSIGVKDGKITKF--SLRELKGDNKIKVEKGKIILPGLIDVHVHL 60
L+ G + + I + V DG+I + S++ G + ++++PG ID H H+
Sbjct: 4 LIKNGTIVNDDAIFKSDVLVLDGRIVEIAPSIQPTPGLEVVDATD-RLVIPGGIDPHTHM 62
Query: 61 R--DFNETHKETIETGTKAAVHGGITTVFDMPNTKPPVMDEKTL----KMREFLFKKKSY 114
+ E K+ GT+AAV GG T + D P E L + R + K
Sbjct: 63 QLPFMGEIAKDDFHRGTEAAVAGGTTMIIDF---VIPTKGESLLVAYDRWRGWA-DPKVV 118
Query: 115 ADYALGFLLAGNEPVKADFYKIFMGASTG-----------GIYSKNFEEDY------AKA 157
DY L + P A +I GA G G++ EE Y AK
Sbjct: 119 CDYGLSMAITSWGPEIAKEMEIVTGAEYGINSFKFFLAYAGVFMVRDEEFYQGMIQCAKL 178
Query: 158 LDITSVHAEDYELISKYPE----------------RPPIVEISAIKKALNAARKVKKPLH 201
+ VHAE+ +I++ E RP +E A +A A + PL+
Sbjct: 179 RALARVHAENGSVIAERCEHLLSSGITGPEGHTQSRPEELEAEATFRACTMASQANCPLY 238
Query: 202 ICHVSTREGLKEILEANIPWVSFEVTPHHLFLT-------RKDYEKSKLLKVYPPL-RDE 253
+ HV ++ I P L +D+ + + PPL RD
Sbjct: 239 VVHVMSKGAAAAIAHHRKKGAVVFGEPIAAGLATDGSHYYNEDWLHAARYVMSPPLSRDP 298
Query: 254 SDRRYLWEKL--DNVPIIASDHAPHTLEDKERG-------AAGLPGLETEVALLLD-AVN 303
S L + L + + A+D+ + K G G+ G+E ++++ D V+
Sbjct: 299 STPSALMKLLAAGELHLTATDNCTFDCQQKSLGKDDFTKIPNGVNGVEDRMSVVWDKGVH 358
Query: 304 RGMLELWDVVEKMSLNPARIFR-IKNKG-WGEGKDADFAIVDMKKEWTIKAEEFYTKAGW 361
G+++ V S A+IF KG G DAD I + TI + + +
Sbjct: 359 AGIIDPMRFVAVTSTMAAKIFNCYPQKGRIAVGSDADIVIWNANATRTISKDTHHHAIDF 418
Query: 362 TPYEGWKVRGKVIMTILRGEIVMEDDEV 389
+EG +V G +TI RG V + ++
Sbjct: 419 NIFEGMQVHGVPEITISRGRTVWANGQL 446
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.139 0.409
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 158654177
Number of Sequences: 2977
Number of extensions: 6885947
Number of successful extensions: 16107
Number of sequences better than 1.0e-10: 83
Number of HSP's better than 0.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 64
Number of HSP's that attempted gapping in prelim test: 15786
Number of HSP's gapped (non-prelim): 113
length of query: 404
length of database: 189,106,746
effective HSP length: 55
effective length of query: 349
effective length of database: 156,189,961
effective search space: 54510296389
effective search space used: 54510296389
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 166 (69.1 bits)