BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1201 (purL) DE:phosphoribosylformylglycinamidine synthase II
(purL)
(705 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||A75026 phosphoribosylformylglycinamidine synthase II (purl)... 1423 0.0
pir||A71211 probable phosphoribosylformylglycinamidine synthase ... 1203 0.0
sp|O27427|PURL_METTH PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 645 0.0
sp|Q58660|PURL_METJA PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 643 0.0
pir||A70458 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 552 e-156
sp|P12042|PURL_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 530 e-149
gi|11499524 phosphoribosylformylglycinamidine synthase II (purL)... 529 e-149
gb|AAK40940.1| Phosphoribosylformylglycinamidine synthase II (FG... 528 e-149
emb|CAB57670.1| (Y18930) phosphoribosylformylglycinamidine synth... 528 e-149
gb|AAF82794.1|AF275718_1 (AF275718) phosphoribosylformylglycinam... 523 e-147
gb|AAF23789.1|AF213822_4 (AF213822) PUR-Q [Zymomonas mobilis] 513 e-144
dbj|BAB04348.1| (AP001509) phosphoribosylformylglycinamidine syn... 511 e-144
pir||T51701 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 510 e-143
pir||S74494 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 503 e-141
pir||C75545 phosphoribosylformylglycinamidine synthase II - Dein... 495 e-139
gb|AAG19309.1| (AE005026) phosphoribosylformylglycinamide syntha... 486 e-136
emb|CAB56359.1| (AL118514) phosphoribosyl formylglycinamidine sy... 483 e-135
emb|CAC12194.1| (AL445066) phosphoribosylformylglycinamidine syn... 472 e-132
dbj|BAA89451.1| (AB003162) 5'-phosphoribosyl-N-formylglycinamidi... 470 e-131
sp|P35852|PURL_LACCA PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 465 e-130
pir||JC1290 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 465 e-130
gb|AAA62986.1| (U15182) phosphoribosylformylglycinamidine syntha... 456 e-127
sp|P54876|PURL_MYCTU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 452 e-126
gb|AAB41455.1| (U34956) phosphoribosylformylglycinamidine syntha... 447 e-124
pir||B81370 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 432 e-120
pir||H72276 phosphoribosylformylglycinamidine synthase II - Ther... 394 e-108
emb|CAA04218.1| (AJ000662) PurL protein [Wolinella succinogenes] 189 7e-47
sp|P26500|PURL_METTM PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 164 3e-39
sp|P15254|PURL_ECOLI PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 129 1e-28
pir||G81961 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 128 2e-28
pir||SYECPG phosphoribosylformylglycinamidine synthase (EC 6.3.5... 127 4e-28
pir||G81017 phosphoribosylformylglycinamidine synthase NMB1996 [... 127 5e-28
pir||B83175 phosphoribosylformylglycinamidine synthase PA3763 [i... 124 3e-27
pir||A82272 phosphoribosylformylglycinamidine synthase VC0869 [i... 124 4e-27
gb|AAB08888.1| (U68728) phosphoribosylformylglycinamidine synthe... 118 2e-25
dbj|BAA20816.1| (AB002359) KIAA0361 [Homo sapiens] 116 1e-24
pir||H64090 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 115 2e-24
sp|P43847|PURL_HAEIN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 115 2e-24
pir||T11661 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 114 4e-24
gi|6321498 5'-phosphoribosylformyl glycinamidine synthetase; Ade... 112 2e-23
gb|AAA50357.1| (U14566) formylglycinamide ribonucleotide synthet... 109 8e-23
pir||T20718 hypothetical protein F10F2.2 - Caenorhabditis elegan... 108 2e-22
gb|AAA75111.2| (U33322) FGAM synthetase [Synechococcus PCC7942] 108 3e-22
gb|AAF52329.1| (AE003612) ade2 gene product [Drosophila melanoga... 108 3e-22
sp|P35421|PUR4_DROME PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ... 106 9e-22
pir||S77614 phosphoribosylformylglycinamidine synthase (EC 6.3.5... 105 2e-21
gb|AAF31730.1|AC020579_7 (AC020579) putative phosphoribosylformy... 103 8e-21
sp|Q58089|Y676_METJA PUTATIVE HYDROGENASE EXPRESSION/FORMATION P... 78 4e-13
pir||B69125 hydrogenase expression/formation protein HypE - Meth... 75 2e-12
pir||E75040 hydrogenase expression/formation protein (hype) PAB0... 75 3e-12
pir||D71121 probable hydrogenase expression/formation protein - ... 73 8e-12
>pir||A75026 phosphoribosylformylglycinamidine synthase II (purl) PAB1201 -
Pyrococcus abyssi (strain Orsay)
>gi|5459161|emb|CAB50647.1| (AJ248288)
phosphoribosylformylglycinamidine synthase II (purL)
[Pyrococcus abyssi]
Length = 705
Score = 1423 bits (3644), Expect = 0.0
Identities = 705/705 (100%), Positives = 705/705 (100%)
Query: 1 MLPREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDA 60
MLPREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDA
Sbjct: 1 MLPREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDA 60
Query: 61 GVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPL 120
GVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPL
Sbjct: 61 GVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPL 120
Query: 121 EKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHS 180
EKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHS
Sbjct: 121 EKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHS 180
Query: 181 YVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLE 240
YVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLE
Sbjct: 181 YVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLE 240
Query: 241 AVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQER 300
AVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQER
Sbjct: 241 AVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQER 300
Query: 301 MLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIE 360
MLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIE
Sbjct: 301 MLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIE 360
Query: 361 WPMKEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAV 420
WPMKEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAV
Sbjct: 361 WPMKEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAV 420
Query: 421 LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPER 480
LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPER
Sbjct: 421 LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPER 480
Query: 481 PEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPR 540
PEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPR
Sbjct: 481 PEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPR 540
Query: 541 GPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILNLIENDLVTF 600
GPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILNLIENDLVTF
Sbjct: 541 GPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILNLIENDLVTF 600
Query: 601 VHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITLPEDKVEEAKE 660
VHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITLPEDKVEEAKE
Sbjct: 601 VHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITLPEDKVEEAKE 660
Query: 661 IAKISIVGRVGGDNFALEVNGEKVEKDIEELSRIYWNYMYDLLEL 705
IAKISIVGRVGGDNFALEVNGEKVEKDIEELSRIYWNYMYDLLEL
Sbjct: 661 IAKISIVGRVGGDNFALEVNGEKVEKDIEELSRIYWNYMYDLLEL 705
>pir||A71211 probable phosphoribosylformylglycinamidine synthase II - Pyrococcus
horikoshii >gi|3258397|dbj|BAA31080.1| (AP000007) 705aa
long hypothetical phosphoribosylformylglycinamidine
synthase II [Pyrococcus horikoshii]
Length = 705
Score = 1203 bits (3078), Expect = 0.0
Identities = 568/705 (80%), Positives = 648/705 (91%), Gaps = 1/705 (0%)
Query: 1 MLPREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDA 60
M P+EEK+IRERLGREPN+VE+AMLEVMWSEHVSYKSSRKWLKLLPTKNEHV+LGPGEDA
Sbjct: 1 MFPQEEKLIRERLGREPNDVERAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVVLGPGEDA 60
Query: 61 GVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPL 120
G++KFD+ TWIVIGIESHNHPSAVEPYGGAATG+GGIVRDILCMGARPIALLDPIRFGPL
Sbjct: 61 GIIKFDDKTWIVIGIESHNHPSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPL 120
Query: 121 EKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHS 180
EKEKNRYLFEYVVKGI+DYGNRIGVPTVGGETEFDESLDNYTLVNV CVGIMKPEHLVHS
Sbjct: 121 EKEKNRYLFEYVVKGISDYGNRIGVPTVGGETEFDESLDNYTLVNVACVGIMKPEHLVHS 180
Query: 181 YVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLE 240
YVT+PGLKL++VGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLE
Sbjct: 181 YVTEPGLKLIIVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLE 240
Query: 241 AVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQER 300
AVYTGKV+ALKDLGGGGLTCAASEM GK+G GA+IYAD+V LREPGMTPLEVMISESQER
Sbjct: 241 AVYTGKVRALKDLGGGGLTCAASEMVGKRGFGAIIYADKVLLREPGMTPLEVMISESQER 300
Query: 301 MLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIE 360
MLFAV PEDVEELA+IFEKYELEW+VVGE+IEEP+F+VYWKG KVA+LPI+LLT VPTIE
Sbjct: 301 MLFAVRPEDVEELARIFEKYELEWSVVGEVIEEPKFIVYWKGSKVAELPIDLLTEVPTIE 360
Query: 361 WPMKEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAV 420
WPMKEYK+EE+V P I+L +AF+ VW SPNIVAKRW+WEQYDHEVQGRTVVKPGFD+AV
Sbjct: 361 WPMKEYKIEEEVGIPRISLQEAFEKVWRSPNIVAKRWIWEQYDHEVQGRTVVKPGFDSAV 420
Query: 421 LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPER 480
LKIN EYG+AIT+DGNP++CYLNPYHGAMG VAEVVRNLVSVGAKPLALVDNLNFASPER
Sbjct: 421 LKINEEYGIAITADGNPNHCYLNPYHGAMGLVAEVVRNLVSVGAKPLALVDNLNFASPER 480
Query: 481 PEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPR 540
PEVYWSF ETVKGLADAAKAF+LAYVSGNVSFYNE+VD+P+KPTPVVAG+GKVKL IP+
Sbjct: 481 PEVYWSFAETVKGLADAAKAFNLAYVSGNVSFYNEIVDKPIKPTPVVAGVGKVKLSKIPK 540
Query: 541 GPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILNLIENDLVTF 600
GP GDV+ L+G T+RELGGSELYRVLGI+ GIAPRVNLE E+ NA +IL LI LV+F
Sbjct: 541 GPNKGDVVTLVGETKRELGGSELYRVLGIRKGIAPRVNLEVERKNAESILRLINASLVSF 600
Query: 601 VHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITLPEDKVEEAKE 660
VHD+SRGG+ VALAE++A FNVG++ + ++FAFSESHGRY++ LPE K+EEA+E
Sbjct: 601 VHDLSRGGLLVALAEVAALFNVGMEVTIKTDMNPVEFAFSESHGRYLVVLPERKLEEARE 660
Query: 661 IAKISIVGR-VGGDNFALEVNGEKVEKDIEELSRIYWNYMYDLLE 704
I + ++GR +G ++F++++N E + ++++L +YWN +Y L++
Sbjct: 661 ITDLKVIGRIIGSNSFSVKINDEVLLWNLDKLKDVYWNTLYRLMD 705
>sp|O27427|PURL_METTH PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II (FGAM SYNTHASE II)
>gi|7428514|pir||G69049
phosphoribosylformylglycinamidine synthase (EC 6.3.5.3)
component II - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622483|gb|AAB85851.1| (AE000900)
phosphoribosylformylglycinamidine synthase II
[Methanobacterium thermoautotrophicum]
Length = 714
Score = 645 bits (1645), Expect = 0.0
Identities = 340/656 (51%), Positives = 451/656 (67%), Gaps = 10/656 (1%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVK 64
E + IR+ LGR+PN +E ML+VM+SEH SYKSSR L L PT+ E VI+GPG+DAGVV+
Sbjct: 7 EMEFIRKELGRDPNPLEYGMLDVMFSEHCSYKSSRPVLGLFPTEGEDVIIGPGDDAGVVE 66
Query: 65 FDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEK 124
+ +VIGIESHNHPSA+EPYGGA TGIGGI+RDI+ MGA P+ALLD +RFG LE +K
Sbjct: 67 ITDELALVIGIESHNHPSAIEPYGGAGTGIGGILRDIISMGAMPVALLDSLRFGYLEDQK 126
Query: 125 NRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTK 184
+RYLFE+VV+GI+DYGNR+GVPTV GE EFDE+ LVNV+C G++ + +
Sbjct: 127 SRYLFEHVVRGISDYGNRVGVPTVAGEVEFDENFQLNPLVNVMCAGLVPKNDIKRGIAPR 186
Query: 185 PGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYT 244
PG +L+G RTGRDGIHGVTFASEEL+ ++E EDR AVQ+ DPFT+K+++EA+ E +
Sbjct: 187 PGDVFLLMGGRTGRDGIHGVTFASEELTSSSELEDRPAVQVGDPFTKKMVMEASFEIMDE 246
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+V +KDLGGGGLTC SE+ K GA + + +PLRE GMTP E+M+SESQERM+F
Sbjct: 247 IEVSGVKDLGGGGLTCCISELVAKCDNGARVSLEAIPLREEGMTPYEIMLSESQERMIFV 306
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIEWPMK 364
+ P+DVE +I KYEL AV+GE+ + R +V +G+ +ADLP +LL + P +E +
Sbjct: 307 MAPDDVEAAMEICRKYELPAAVIGEVTDTGRMIVESEGEVIADLPAKLLADPPVVEREAR 366
Query: 365 EYKLEE-DVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAVLKI 423
+ +L E VE L + SSPNI +KRWV+ QYDHEVQ RTVVKPG DAAVL++
Sbjct: 367 KPQLPEGQVEVKHPPLKDTLLKLISSPNIASKRWVYRQYDHEVQIRTVVKPGDDAAVLRV 426
Query: 424 NGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPERPEV 483
+G G+A+T D N + L+PY G +V E +RN+VS+GA P+ +VD LNF +PE+PEV
Sbjct: 427 DGTTGVALTVDCNSIHTKLDPYGGGAASVGEAIRNVVSMGAWPVCIVDCLNFGNPEKPEV 486
Query: 484 YWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPR--G 541
+W F E V+G+AD A+ F +SGNVSFYNE V P+PVV GK+ L I
Sbjct: 487 FWQFRECVRGMADMAETFSTPVISGNVSFYNETEGVTVNPSPVVGVAGKLSLDSIKTLDF 546
Query: 542 PRDGDVIALIGSTRRELGGSELYR-VLGIKGGIAPRVNLEEEKGNALAILNLIE--NDLV 598
+G+ I +IG T ELG SE R V GI G P +L+ E A A+ +I+ + V
Sbjct: 547 KDEGEEIVVIGETGPELGASEYLRTVHGIVDGKPPETDLKAEFEAAKAVKEIIDGSGNKV 606
Query: 599 TFVHDVSRGGVAVALAELSAWFNVGVK---AKFTSSFKSIDFA-FSESHGRYIITL 650
T VHD S GG+AVA+AE++ +G + K F++I A FSES+GRYI+T+
Sbjct: 607 TAVHDCSAGGIAVAVAEMAIKSGIGARIDPMKIPGRFRNIHEALFSESNGRYIMTV 662
>sp|Q58660|PURL_METJA PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II (FGAM SYNTHASE II)
>gi|2129201|pir||G64457
phosphoribosylformylglycinamidine synthase (EC 6.3.5.3)
component II - Methanococcus jannaschii
>gi|1591899|gb|AAB99270.1| (U67567)
phosphoribosylformylglycinamidine synthase II (purL)
[Methanococcus jannaschii]
Length = 733
Score = 643 bits (1640), Expect = 0.0
Identities = 345/722 (47%), Positives = 489/722 (66%), Gaps = 37/722 (5%)
Query: 7 KIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLP-TKNE----HVILGPGEDAG 61
K I + LGR+PN +E AM E +WSEH +Y++S+K L++ T NE ++++G G+DA
Sbjct: 7 KYIEKVLGRKPNHIELAMFENLWSEHCAYRTSKKLLRMFAKTVNEKTSKNIVVGIGDDAA 66
Query: 62 VVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPL- 120
V++ + I +ESHNHPS ++PY GAATG+GGIVRD+L MGA+PIALLDP+RFG +
Sbjct: 67 VIRLKNDICLAIAMESHNHPSYIDPYNGAATGVGGIVRDVLSMGAKPIALLDPLRFGDIF 126
Query: 121 --EKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLV 178
E +K R+L E VVKGI DYGNRIGVPTVGGE EFD S D LVNVVCVG++K ++
Sbjct: 127 GKEGDKVRWLIEGVVKGIGDYGNRIGVPTVGGECEFDSSFDYNNLVNVVCVGLVKENEII 186
Query: 179 HSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEAT 238
+PGL L+L+G+ TGRDGI G +FAS++L+E +EEE R +VQ+ D F+EK LI+A
Sbjct: 187 TGKAKEPGLSLILIGS-TGRDGIGGASFASKDLTEESEEE-RPSVQVGDAFSEKCLIDAV 244
Query: 239 LEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQ 298
LEAV TGKVKA+KDLG GL+ A+SEM G+G +Y + V LREP +TP E+M+SESQ
Sbjct: 245 LEAVKTGKVKAMKDLGAAGLSGASSEMCYGGGVGCELYLENVVLREP-LTPYEIMVSESQ 303
Query: 299 ERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPT 358
ERML AVEP EE+ +IF+KYEL +V+G+ I E R + +KG+ V DLP++LL P
Sbjct: 304 ERMLLAVEPGSEEEIIEIFKKYELPASVIGKTIPEKRIIAKYKGEVVVDLPLDLLCEAPL 363
Query: 359 IEWPMKEYKLEEDVETPDIALSKAFDLVW----SSPNIVAKRWVWEQYDHEVQGRTVVKP 414
+ KE E++ + I + + + V SPNI +K W+++QYDHEVQ RTVVKP
Sbjct: 364 YDREGKEDLKEKEDDKEKIKMPEDLNAVLLKLLESPNICSKEWIYQQYDHEVQIRTVVKP 423
Query: 415 GFDAAVLKINGEY--GLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDN 472
G DAAVL+IN Y G+A+T+D N YC LNPY GA+ VAE VRNL +VGA+P+A++DN
Sbjct: 424 GKDAAVLRINEVYPMGIALTTDCNSRYCKLNPYVGAVNAVAEAVRNLATVGAEPIAMLDN 483
Query: 473 LNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVV----DRPVKPTPVVA 528
LNF +PERPE +W E +KGLADAA+ F++ V GNVS YNE V + P+ PTP +
Sbjct: 484 LNFGNPERPERFWQLAECIKGLADAAEFFEIPVVGGNVSLYNETVIEGKEHPINPTPAIF 543
Query: 529 GIGKVKLKDIPRGP-------RDGDVIALIGSTRRELGGSELYRVL-GIKGGIAPRVNLE 580
+GKV +D+ + P ++GD++ + T+ E+GGSE Y+V+ + G PRV+LE
Sbjct: 544 VLGKV--EDVEKVPGVLDNKIKEGDILIITNETKDEMGGSEYYKVIHNTEEGRVPRVDLE 601
Query: 581 EEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFT----SSFKSID 636
+EK + +++ LV+ D SRGG+AVALA+++ N+G++ T ++ +
Sbjct: 602 KEKKIYEEVREVVKEGLVSEAVDCSRGGLAVALAKMAVLNNIGLEVDLTEYNKNNLRDDI 661
Query: 637 FAFSESHGRYIITL-PEDKVEEAKEIAKISIVGRVGGDNFALEVN-GEKVEKDIEELSRI 694
FSE+ GR I+ + E+K + +++ I+G+VGG +++N + V D+EE+ +
Sbjct: 662 LLFSETSGRIILAVRDENKDKVLSKLSSAYIIGKVGGSRLKIKINEKDVVNLDVEEMKKR 721
Query: 695 YW 696
Y+
Sbjct: 722 YY 723
>pir||A70458 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) component
II - Aquifex aeolicus >gi|2984116|gb|AAC07653.1|
(AE000758) phosphoribosylformylglycinamidine synthase II
[Aquifex aeolicus]
Length = 745
Score = 552 bits (1407), Expect = e-156
Identities = 315/730 (43%), Positives = 440/730 (60%), Gaps = 32/730 (4%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVK 64
E + I + L REPN VE +L +WSEH SYKSS+K LK PTK E V+ GPGE+AGVVK
Sbjct: 14 EYRKILKTLKREPNHVELGVLGALWSEHCSYKSSKKHLKKFPTKAEWVVQGPGENAGVVK 73
Query: 65 FDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEK 124
DE W+ +ESHNHPS +EP+ GAATG+GGI+RD+L MGARPIAL D +RFG +
Sbjct: 74 IDEKVWVAFKVESHNHPSYIEPFHGAATGVGGIIRDVLSMGARPIALADSLRFGEFNYHE 133
Query: 125 NRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTK 184
+ L + VV GI+ YGN IGVPTV GET F+ S LVN C+G++ + + T+
Sbjct: 134 TKRLVKGVVSGISFYGNCIGVPTVAGETVFEPSYKTNPLVNAFCLGVIPAGRMYRARATR 193
Query: 185 PGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYT 244
G L L+G+ TGRDGI G AS E SE+ EE+ R VQI DP+ K L+EA +E V
Sbjct: 194 EGQLLFLIGSSTGRDGIFGAVMASGEFSEDVEEK-RPNVQIGDPYFGKKLVEAIMEIVEK 252
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+ ++DLG GL +ASE+A K G +Y + VPLRE M P E+++SESQERML
Sbjct: 253 DLIVGMQDLGAAGLAGSASEIAAKSEKGVELYLENVPLREKDMNPYEILLSESQERMLLV 312
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTN-VPTIEWPM 363
VE E+VE++ +I K+ LE AVVG+I ++ F Y+KG+ VA+LP+ L+ + P + P
Sbjct: 313 VEEENVEKVKEIANKWHLEGAVVGKITDDDTFRAYYKGELVAELPVSLIVDEAPVYDRPY 372
Query: 364 KEYKLEEDV------ETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFD 417
KE + ++V E P + +A + SSPNI K WV+ QYD++V T++ PG D
Sbjct: 373 KEPEYMKEVRNFNQEELPQTDVKEALKKLLSSPNISCKEWVYTQYDYQVGTNTLLIPGHD 432
Query: 418 AAVLK--------INGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLAL 469
AAVL+ + E G+AI+S+GN YLNPY G VAEV RNL VGAKPLA+
Sbjct: 433 AAVLRLKWVLRPELTTEKGIAISSEGNGRMVYLNPYEGGKFVVAEVCRNLACVGAKPLAI 492
Query: 470 VDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVD----RPVKPTP 525
D LNF +PERPE+ W FV+ V+G+A+A + + VSGNVS YNE V+ R V PTP
Sbjct: 493 TDCLNFGNPERPEIMWQFVKAVEGMAEACEELGIPVVSGNVSLYNETVEKNEIRNVFPTP 552
Query: 526 VVAGIGKVKL--KDIPRGPRDGDVIALIGSTRR--ELGGSELYRVL-GIKGGIAPRVNLE 580
+V G+G ++ K P + L+G+ L GSE +V+ G+ G P V+LE
Sbjct: 553 IVVGVGVLEKAEKYTPSKVEKESELYLVGNLEENLRLDGSEYLKVIHGLIKGDVPPVDLE 612
Query: 581 EEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFS 640
+EK +++ +L+T HDVS GG+ +AL E+ G++ + + + F FS
Sbjct: 613 KEKILINLLISFNNKELITCAHDVSVGGLLIALLEMVFRTPYGLEVEVYTDERPDVFFFS 672
Query: 641 ESHGRYIITLPEDKVEEAKEIAKIS-----IVGRVGGD-NFALEVNGEK-VEKDIEELSR 693
E+ R II + DK EE K + + +G+ + + NG+ +E ++EE +
Sbjct: 673 ENPTRVIIGVESDKAEEVKNAVEKAGLEWMYIGKTTEEKKIKVTFNGDTLLEDELEEYEK 732
Query: 694 IYWNYMYDLL 703
++ + LL
Sbjct: 733 LWRTSLEKLL 742
>sp|P12042|PURL_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II (FGAM SYNTHASE II)
>gi|68653|pir||SYBS2G phosphoribosylformylglycinamidine
synthase (EC 6.3.5.3) component II - Bacillus subtilis
>gi|143369|gb|AAA22679.1| (J02732) phosphoribosylformyl
glycinamidine synthetase II (PUR-Q) [Bacillus subtilis]
>gi|2632962|emb|CAB12468.1| (Z99107)
phosphoribosylformylglycinamidine synthetase I [Bacillus
subtilis]
Length = 742
Score = 530 bits (1350), Expect = e-149
Identities = 295/707 (41%), Positives = 423/707 (59%), Gaps = 19/707 (2%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVK 64
E +I LGR PN E + VMWSEH SYK+S+ L+ PT E V+ GPGE AG+V
Sbjct: 27 EFALIESILGRLPNYTEIGIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVD 86
Query: 65 FDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEK 124
++ +V IESHNHPSA+EPY GAATG+GGI+RD+ MGARPIA+L+ +RFG L +
Sbjct: 87 IGDNQAVVFKIESHNHPSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPR 146
Query: 125 NRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTK 184
+YLFE VV GIA YGN IG+PTVGGE +FD S + LVN +CVG++ E +
Sbjct: 147 VKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKG 206
Query: 185 PGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYT 244
G ++ VG +TGRDGIHG TFASEE+S+++EE+ RSAVQ+ DPF EKLL+EA LE +
Sbjct: 207 VGNTVMYVGAKTGRDGIHGATFASEEMSDSSEEK-RSAVQVGDPFMEKLLLEACLEVIQC 265
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+ ++D+G GLT +++EMA K G G + D +P RE GMT E+M+SESQERML
Sbjct: 266 DALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLV 325
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLT-NVPTIEWPM 363
+E +E+ IF+KY+LE VG + ++ + KG+ V +LP++ L P P
Sbjct: 326 IERGREQEIIDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPS 385
Query: 364 KE---YK--LEEDVETPDIA-LSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFD 417
+E Y+ LE DV P I ++ + P I +K WV++QYD+ V+ TVV PG D
Sbjct: 386 QEPAYYREFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSD 445
Query: 418 AAVLKING-EYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFA 476
A VL+I G + LA+T+D N Y YL+P G VAE RN++ GA+PLA+ DNLNF
Sbjct: 446 AGVLRIRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFG 505
Query: 477 SPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLK 536
+PE+PE+ W + G+++A + GNVS YNE + PTPV+ +G ++
Sbjct: 506 NPEKPEILWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDT 565
Query: 537 ---DIPRGPRDGDVIALIGSTRRELGGSELYRVL-GIKGGIAPRVNLEEEKGNALAILNL 592
+ GD++ +IG T+ E GSEL ++ G G AP+++L+ E A+L+
Sbjct: 566 AHITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLDA 625
Query: 593 IENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITLPE 652
I+ V HDVS GG+ VA+AE S + A T ++ FSES R+++++ +
Sbjct: 626 IKKGFVQSAHDVSEGGLGVAIAE-SVMTTENLGANVTVEGEAA-LLFSESQSRFVVSVKK 683
Query: 653 DKVEEAKEIAKISI-VGRVGGDNFALEVN---GEKVEKDIEELSRIY 695
+ + K ++ +G V D N + + +EL R++
Sbjct: 684 EHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVW 730
>gi|11499524 phosphoribosylformylglycinamidine synthase II (purL) [Archaeoglobus
fulgidus] >gi|7428515|pir||C69492
phosphoribosylformylglycinamidine synthase (EC 6.3.5.3)
component II - Archaeoglobus fulgidus
>gi|2648599|gb|AAB89311.1| (AE000969)
phosphoribosylformylglycinamidine synthase II (purL)
[Archaeoglobus fulgidus]
Length = 765
Score = 529 bits (1347), Expect = e-149
Identities = 312/694 (44%), Positives = 412/694 (58%), Gaps = 39/694 (5%)
Query: 14 GREPNEVEKAMLEVMWSEHVSYKSSRKWLK---LLPTKNEHVILGPGEDAGVVKFDESTW 70
GR P ++E L WSEH YKSS+ +L+ L +K ++VI EDAGVV+FD+
Sbjct: 51 GRNPYDIELQSLAQAWSEHCCYKSSKYYLRQYLLEASKADYVISAIEEDAGVVEFDDEYA 110
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEKNR---- 126
V ESHNHPSA+EPYGGAATGIGGI+RD+LCMGA+PIAL+DP+ FG L+ +
Sbjct: 111 YVTAFESHNHPSAIEPYGGAATGIGGILRDVLCMGAQPIALIDPLFFGNLDTPYEKLPRG 170
Query: 127 -----YLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSY 181
YL + VV GI DYGNR+G+PTV G FD S LVNV CVGI++ + ++HS
Sbjct: 171 TKHPLYLLKGVVAGIRDYGNRVGIPTVAGMVFFDNSYLTNCLVNVGCVGIVRKDRIIHSR 230
Query: 182 VTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEA 241
G VL G +TGRDGIHGVTFAS EL E +EEE R AVQ+ +P ++ LI A LE
Sbjct: 231 AGGAGDLFVLAGGKTGRDGIHGVTFASAELDEKSEEEARGAVQLGNPIMKEPLIHACLEV 290
Query: 242 VYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERM 301
V G + +KDLGGGGL+C EMA G GA +Y D+VPL+E GM P E+ ISESQERM
Sbjct: 291 VEKGLLTGMKDLGGGGLSCVIGEMALAAGFGAEVYLDKVPLKEEGMAPWEIWISESQERM 350
Query: 302 LFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIEW 361
+ V PE ++E+ IF+K+++ VVG++I E +Y+KG K+ ++ E +T+ P
Sbjct: 351 MLTVRPEHIDEVLYIFQKWDVPATVVGKVIPEKITRIYYKGYKIYEMDTEFVTSGPEYCR 410
Query: 362 P----MKEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKP--- 414
P E +L E+VE P K F + S PN K W+ QYDHEV+ TV+KP
Sbjct: 411 PYVARKPEKELHEEVE-PPADYVKTFMKMLSHPNAAFKEWIVRQYDHEVRASTVLKPLQG 469
Query: 415 ------GFDAAVLKINGEY-GLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPL 467
DAAV+K + GLAIT+D NP C ++PY GA + E+VRNLV+V A P
Sbjct: 470 KMNFETHGDAAVIKPTRSFRGLAITADVNPWMCKVDPYWGAASSFDEMVRNLVAVNAVPH 529
Query: 468 ALVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVV 527
+ D LNF +PE+PE FVE VK L AK + VSGNVSFYNE V PTP +
Sbjct: 530 SFNDCLNFGNPEKPERMGEFVEAVKALGWMAKGVGVPCVSGNVSFYNETPYGAVAPTPSL 589
Query: 528 AGIGKVK--LKDIPRGPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGN 585
G+G V+ K I + + L+G T E GGS V+G + PR + E K
Sbjct: 590 LGVGIVEDVRKAITSEFKGRGAVILVGETHNEFGGSLYSAVMGQRCHKVPRTSPERLKTY 649
Query: 586 ALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGR 645
+ A+L V HDVS GG+AV +AE+S +G +A SF + FSES+ R
Sbjct: 650 SDAMLESFRKFEVKACHDVSMGGLAVCIAEMSFGRGLGFEAARELSFVEL---FSESNTR 706
Query: 646 YIITLPEDKVE------EAKEIAKISIVGRVGGD 673
+++ +PE E AKE+ K ++G GG+
Sbjct: 707 WVVEVPESVAEGYAEFFRAKEL-KAEVIGYSGGE 739
>gb|AAK40940.1| Phosphoribosylformylglycinamidine synthase II (FGAM synthase II)
(purL) [Sulfolobus solfataricus]
Length = 709
Score = 528 bits (1346), Expect = e-149
Identities = 296/713 (41%), Positives = 445/713 (61%), Gaps = 21/713 (2%)
Query: 1 MLPREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILG--PGE 58
+LP E IR+RLGREPNE E +++ +WSEH SYKSS+ +LK + +VI+G +
Sbjct: 5 LLPIEMDEIRKRLGREPNETEWRVIDAVWSEHCSYKSSKIFLKSFSIDSPNVIMGIKDWQ 64
Query: 59 DAGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFG 118
DAG V + +VI +ESHNHPSA++P+ GAATG+GGI+RDI+ GA+PIAL+D IR G
Sbjct: 65 DAGAVDIGDGWAVVIKVESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALMDMIRVG 124
Query: 119 PLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLV 178
L+ +KN +L + ++ GIA YGN IGVP VGGE FD++ ++ LV+V +GI++ + +
Sbjct: 125 NLKIKKNVWLLKNIIAGIAAYGNSIGVPVVGGELSFDDTYNDNPLVDVAAIGIVRKDKIK 184
Query: 179 HSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEAT 238
S V K GLKLVL G TG DG+ G +FAS +LS E++ AVQI DPF K++++ T
Sbjct: 185 PSIVDKAGLKLVLAG-LTGVDGLGGASFASRKLS---GEDEIGAVQIADPFAGKIILDVT 240
Query: 239 LEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQ 298
LE KV+A+KDLGGGGL A +E+ GLGA + +++PLR M P +V+ISE+Q
Sbjct: 241 LE--IADKVEAIKDLGGGGLAVAVTEIT--NGLGATVDIEKIPLRVKNMNPSDVIISETQ 296
Query: 299 ERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPT 358
ERML+AVE ++V+E+ + FE+YE +V+GEI EP + G + LP +L N P
Sbjct: 297 ERMLYAVEEKNVKEVCEAFEEYEYPCSVIGEITNEPVIKFRYIGKDLVSLPTNVLLNPPR 356
Query: 359 IEWPMKEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPG-FD 417
WP+K K + + D+ L A V + P++V+K W + Q+D+EV TVVKPG D
Sbjct: 357 FLWPIKNTKKNVEEKIVDLPLESAIYTVLTHPDLVSKGWAYSQFDYEVNTSTVVKPGDAD 416
Query: 418 AAVLKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFAS 477
+AV+ + LAI +D NP C + Y G VAE RNL +VGA+ + VD+L F
Sbjct: 417 SAVVSLPNGKLLAIKADANPDMCAEDGYECGKGIVAEAYRNLATVGARGMVAVDHLQFGD 476
Query: 478 PERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNE-VVDRPVKPTPVVAGIGKVKLK 536
P++ EVY++FVE ++G+ +A + F++ V G VSFYNE RP+KPTP++ G V+ K
Sbjct: 477 PKKAEVYYTFVEAIRGIGEATRFFNIPIVGGKVSFYNENNQGRPIKPTPLIVMAGLVQDK 536
Query: 537 DIPRGPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILNLIEND 596
+ D + +G TR+ELGGS L ++ I AP+V L+E+ ++ +++ I
Sbjct: 537 LLKNRVEDNLYVVSVGYTRKELGGSLLSKIFKIPSQ-APKVRLQEDLLSSEVVIDSINEG 595
Query: 597 LVTFVHDVSRGGVAVALAEL---SAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITL--P 651
+TF DVSRGG+A +L + + K+ + + I+ FSES GR+I+ P
Sbjct: 596 KITFAKDVSRGGLAASLFSILVHGYGVEISTKSILSDTDNVIENLFSESSGRFIVLTNEP 655
Query: 652 EDKVEEAKEIAKI-SIVGRVGGDNFALEVNGEKVEKDIEELSRIYWNYMYDLL 703
E VE++K + SI+GRV L + + ++ +++ + Y+N++ +++
Sbjct: 656 EWIVEKSKSKGIVASIIGRVNKKTNILTI--DNIDYNLKNIVDNYFNFLEEVM 706
>emb|CAB57670.1| (Y18930) phosphoribosylformylglycinamidine synthase II [Sulfolobus
solfataricus]
Length = 709
Score = 528 bits (1346), Expect = e-149
Identities = 296/713 (41%), Positives = 445/713 (61%), Gaps = 21/713 (2%)
Query: 1 MLPREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILG--PGE 58
+LP E IR+RLGREPNE E +++ +WSEH SYKSS+ +LK + +VI+G +
Sbjct: 5 LLPIEMDEIRKRLGREPNETEWRVIDAVWSEHCSYKSSKIFLKSFSIDSPNVIMGIKDWQ 64
Query: 59 DAGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFG 118
DAG V + +VI +ESHNHPSA++P+ GAATG+GGI+RDI+ GA+PIAL+D IR G
Sbjct: 65 DAGAVDIGDGWAVVIKVESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALMDMIRVG 124
Query: 119 PLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLV 178
L+ +KN +L + ++ GIA YGN IGVP VGGE FD++ ++ LV+V +GI++ + +
Sbjct: 125 NLKIKKNVWLLKNIIAGIAAYGNSIGVPVVGGELSFDDTYNDNPLVDVAAIGIVRKDKIK 184
Query: 179 HSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEAT 238
S V K GLKLVL G TG DG+ G +FAS +LS E++ AVQI DPF K++++ T
Sbjct: 185 PSIVDKAGLKLVLAG-LTGVDGLGGASFASRKLS---GEDEIGAVQIADPFAGKIILDVT 240
Query: 239 LEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQ 298
LE KV+A+KDLGGGGL A +E+ GLGA + +++PLR M P +V+ISE+Q
Sbjct: 241 LE--IADKVEAIKDLGGGGLAVAVTEIT--NGLGATVDIEKIPLRVKNMNPSDVIISETQ 296
Query: 299 ERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPT 358
ERML+AVE ++V+E+ + FE+YE +V+GEI EP + G + LP +L N P
Sbjct: 297 ERMLYAVEEKNVKEVCEAFEEYEYPCSVIGEITNEPVIKFRYIGKDLVSLPTNVLLNPPR 356
Query: 359 IEWPMKEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPG-FD 417
WP+K K + + D+ L A V + P++V+K W + Q+D+EV TVVKPG D
Sbjct: 357 FLWPIKNTKKNVEEKIVDLPLESAIYTVLTHPDLVSKGWAYSQFDYEVNTSTVVKPGDAD 416
Query: 418 AAVLKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFAS 477
+AV+ + LAI +D NP C + Y G VAE RNL +VGA+ + VD+L F
Sbjct: 417 SAVVSLPNGKLLAIKADANPDMCAEDGYECGKGIVAEAYRNLATVGARGMVAVDHLQFGD 476
Query: 478 PERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNE-VVDRPVKPTPVVAGIGKVKLK 536
P++ EVY++FVE ++G+ +A + F++ V G VSFYNE RP+KPTP++ G V+ K
Sbjct: 477 PKKAEVYYTFVEAIRGIGEATRFFNIPIVGGKVSFYNENNQGRPIKPTPLIVMAGLVQDK 536
Query: 537 DIPRGPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILNLIEND 596
+ D + +G TR+ELGGS L ++ I AP+V L+E+ ++ +++ I
Sbjct: 537 LLKNRVEDNLYVVSVGYTRKELGGSLLSKIFKIPSQ-APKVRLQEDLLSSEVVIDSINEG 595
Query: 597 LVTFVHDVSRGGVAVALAEL---SAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITL--P 651
+TF DVSRGG+A +L + + K+ + + I+ FSES GR+I+ P
Sbjct: 596 KITFAKDVSRGGLAASLFSILVHGYGVEISTKSILSDTDNVIENLFSESSGRFIVLTNEP 655
Query: 652 EDKVEEAKEIAKI-SIVGRVGGDNFALEVNGEKVEKDIEELSRIYWNYMYDLL 703
E VE++K + SI+GRV L + + ++ +++ + Y+N++ +++
Sbjct: 656 EWIVEKSKSKGIVASIIGRVNKKTNILTI--DNIDYNLKNIVDNYFNFLEEVM 706
>gb|AAF82794.1|AF275718_1 (AF275718) phosphoribosylformylglycinamide synthetase II
[Sinorhizobium fredii]
Length = 743
Score = 523 bits (1332), Expect = e-147
Identities = 297/708 (41%), Positives = 413/708 (57%), Gaps = 24/708 (3%)
Query: 3 PREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGV 62
P E + I + REP E + MW+EH SYKSS+KWL+ LPTK VI GPGE+AGV
Sbjct: 21 PDEYERILSLIRREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGV 80
Query: 63 VKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEK 122
V D+ +V +ESHNHPS +EPY GAATG+GGI+RD+ MGARPIA ++ +RFG +
Sbjct: 81 VDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDH 140
Query: 123 EKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYV 182
K R+L VV G+ YGN GVPTVGGE EFD + LVN G+ + + + +S
Sbjct: 141 PKTRHLVSGVVAGVGGYGNSFGVPTVGGEVEFDARYNGNILVNAFAAGLARSDAIFYSKA 200
Query: 183 TKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAV 242
GL +V +G +TGRDG+ G T AS E E+ EE+ R VQ+ DPFTEK L+EA LE +
Sbjct: 201 EGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEK-RPTVQVGDPFTEKCLLEACLELM 259
Query: 243 YTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERML 302
TG V A++D+G GLTC+A EM K LG + D+VP+RE MT E+M+SESQERML
Sbjct: 260 QTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMTAYEMMLSESQERML 319
Query: 303 FAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPI-ELLTNVPTIEW 361
+ PE EE IF K+ L++A+VG+ ++ RF + +G++VA+LPI EL P +
Sbjct: 320 MVLRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGEEVANLPIKELGDEAPEYDR 379
Query: 362 PMKEYKLEEDVETPDIA---LSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDA 418
P K + T DI +++A + S N ++RWV+EQYD +QG ++ PG DA
Sbjct: 380 PWTPAKSPSPLATNDIPRADVAEALLKLVGSANNSSRRWVYEQYDTLIQGNSLQLPGGDA 439
Query: 419 AVLKINGE--YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFA 476
V+++ G LA +SD P Y +P+ G VAE RNL + GA PLA DNLNF
Sbjct: 440 GVVRVEGHATKALAFSSDVTPRYVEADPFEGGKQAVAECWRNLTATGALPLAATDNLNFG 499
Query: 477 SPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKV--- 533
+PERPE+ FV +KG+ +A +A D VSGNVS YNE + + PTP + G+G +
Sbjct: 500 NPERPEIMSQFVHAIKGIGEACRALDFPIVSGNVSLYNETNGQGILPTPTIGGVGLISDW 559
Query: 534 -KLKDIPRGPRDGDVIALIGSTR---RELGGSELYR-VLGIKGGIAPRVNLEEEKGNALA 588
++ I D + I L G+ + S R V G G AP V+L E+
Sbjct: 560 ARMARIRFAAAD-EAILLAGAPEGWGTHIAQSVYMRDVHGRTDGPAPHVDLAHERKVGDF 618
Query: 589 ILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYII 648
+ LI + LVT VHD S GG+A+A+AE++ +G + + I + E GRY++
Sbjct: 619 VRGLIADGLVTAVHDCSSGGLALAVAEMAMASGIGATIEAPAGHDPIAAFYGEDQGRYVV 678
Query: 649 TLPEDKVEEAKEIAK-----ISIVGRVGGDNFALEVNGEKVEKDIEEL 691
T+ +K+E A+ + ++G GG L G+ +EEL
Sbjct: 679 TVTAEKLEAIASRARDAGLSLPVIGTTGGSAVKL---GDAKAVSVEEL 723
>gb|AAF23789.1|AF213822_4 (AF213822) PUR-Q [Zymomonas mobilis]
Length = 734
Score = 513 bits (1306), Expect = e-144
Identities = 293/720 (40%), Positives = 426/720 (58%), Gaps = 23/720 (3%)
Query: 3 PREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGV 62
P E I++ LGR PN V+ + MWSEH SYKSSRK L+ LPT VI GPGE+AGV
Sbjct: 20 PEEYDTIKQALGRTPNLVKLGIFSAMWSEHCSYKSSRKHLRELPTTGSQVICGPGENAGV 79
Query: 63 VKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEK 122
V + + +ESHNHPS +EPY GAATG+GGI+RD+ MGARP+A L +RFG +
Sbjct: 80 VDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANLKHLRFGSPKH 139
Query: 123 EKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYV 182
K +L VV GI YGN +GVPTVGGE F + D LVN + V + + + +S
Sbjct: 140 PKTPHLVSGVVAGIGGYGNCVGVPTVGGEVNFHPAYDGNNLVNAMTVAVAETNKIFYSAA 199
Query: 183 TKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAV 242
+ G +V VG++TGRDGIHG T AS + ++AEE+ R VQ+ DPF+EKLLIEA LE +
Sbjct: 200 SGAGNPIVYVGSKTGRDGIHGATMASADFGKDAEEK-RPTVQVGDPFSEKLLIEACLELM 258
Query: 243 YTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERML 302
+ + A++D+G GLT +A EMA K +G + D VP RE GMTP E+M+SESQERML
Sbjct: 259 ASDAIVAIQDMGAAGLTSSAVEMASKGEVGIELDMDMVPCREEGMTPYEMMLSESQERML 318
Query: 303 FAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPI-ELLTNVPTIEW 361
++P E IF+K+EL++A++G + + V+ WKGD V D+P+ L N P +
Sbjct: 319 MVLKPGREAEAEAIFKKWELDFAIIGRVTDSKHMVLTWKGDIVCDIPLAPLADNAPCYDR 378
Query: 362 PMKEYKLEEDVETPDIALSKAFDLVW--SSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAA 419
P + + + S +LV SP++ ++RW+WEQYD+ V TV PG DAA
Sbjct: 379 PWVATPKAKALGAVPASGSITDNLVTLVGSPDLASRRWIWEQYDNMVGADTVQCPGGDAA 438
Query: 420 VLKING-EYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASP 478
V++++G E LA++ D P YC +P G VAE RN+ +VGA PLA D LNF +P
Sbjct: 439 VVRVHGTEKALAMSVDVTPRYCRADPEEGGKQAVAECYRNITAVGALPLASTDCLNFGNP 498
Query: 479 ERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEV-----VDRPVKPTPVVAGIGKV 533
ERPE+ V +KG+ +A +A D+ VSGNVS YNE + PTP + G+G +
Sbjct: 499 ERPEIMGQIVGAIKGIGEACRALDMPIVSGNVSLYNETRQDDGSSLAILPTPTIGGVGLL 558
Query: 534 ---KLKDIPRGPRDGDVIALIGSTRRELGGSELY--RVLGIKGGIAPRVNLEEEKGNALA 588
+ G+ I L+G++ + G ++ ++ G + G AP V+L +EK
Sbjct: 559 QDWRDSTTIAFKNTGEEIYLVGNSGQGHLGQSIWLRKIAGREEGTAPSVDLAQEKATGDF 618
Query: 589 ILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAK-FTSSFKSIDFAFSESHGRYI 647
I +I++ ++ VHD+S GG+AVALAE++ N+G + + + F E GRY+
Sbjct: 619 IRAMIQDGMLCAVHDISDGGLAVALAEMALAGNIGATVEAHDKAIAEHAYYFGEDQGRYL 678
Query: 648 ITLPED-KVEEAKEIAKISI--VGRVGGDNFALEVNGEKVEKDIEELSRIYWNYMYDLLE 704
++ + A E A I + +G GGD A+ +N + V +E+L + + ++ +L++
Sbjct: 679 VSSTNAVALVSAAEKAGIPVFRLGVTGGD--AVVLNSQSV--SLEKLRKSHEAFLPELMQ 734
>dbj|BAB04348.1| (AP001509) phosphoribosylformylglycinamidine synthetase I [Bacillus
halodurans]
Length = 743
Score = 511 bits (1303), Expect = e-144
Identities = 287/683 (42%), Positives = 406/683 (59%), Gaps = 27/683 (3%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVK 64
E ++ LGR PN E + VMWSEH SYK+S+ LK P + V+ GPGE AG++
Sbjct: 27 EFALVESILGRLPNYTETGLFSVMWSEHCSYKNSKVLLKKFPIDGDKVLQGPGEGAGIID 86
Query: 65 FDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEK 124
+ +V IESHNHPSA+EPY GAATG+GGI+RD+ MGARPI+LL+ +RFG L K
Sbjct: 87 IGDEQAVVFKIESHNHPSAIEPYQGAATGVGGILRDVFSMGARPISLLNSLRFGELTSPK 146
Query: 125 NRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTK 184
RYLFE VV GIA YGN +GVPTVGGE +FD + LVN +CVG++ + +
Sbjct: 147 VRYLFEEVVAGIAGYGNCVGVPTVGGEVQFDPCYEGNPLVNAMCVGLIDHKDIQKGQAKG 206
Query: 185 PGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYT 244
G ++ VG TGRDGIHG TFASEELSE A EE R AVQ+ DPF EKLL+EA LE + +
Sbjct: 207 VGNTVMYVGASTGRDGIHGATFASEELSE-ASEEKRPAVQVGDPFMEKLLLEACLELIKS 265
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+ ++D+G GLT +++EMA K G G + D VP RE GMTP E+M+SESQERML
Sbjct: 266 DALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDHVPQREKGMTPYEMMLSESQERMLIV 325
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLT-NVPTIEWPM 363
V+ +E+ I + L VG++ ++ + + KG+ VAD+P++ L + P P
Sbjct: 326 VKKGREQEIKDIVAHWGLHAVEVGQVTDDKKLRLLHKGEVVADVPVDALAEDAPVYHKPS 385
Query: 364 K------EYKLEEDVETPDIALSKAFDL-VWSSPNIVAKRWVWEQYDHEVQGRTVVKPGF 416
K ++ E+ P IA K L + P I +K WV+EQYD+ VQ TVV PG
Sbjct: 386 KVPAYYEAFQSEKTQWIPTIANVKDTLLSLLQQPTIASKEWVYEQYDYMVQTNTVVSPGS 445
Query: 417 DAAVLKING-EYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNF 475
DAAV++I G + LA+T+D N Y +L+P G +AE RN+V G PL + D LN+
Sbjct: 446 DAAVVRIRGTKKALAMTTDCNSRYLFLDPEVGGKIAIAEAARNIVCSGGVPLGVTDCLNY 505
Query: 476 ASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKL 535
+PE+PE++W ++ G+++A + + GNVS YNE V PTPV+ +G +
Sbjct: 506 GNPEKPEIFWQLEKSTDGMSEACRELGTPVIGGNVSLYNETNGVAVYPTPVIGMVGLI-- 563
Query: 536 KDI-----PRGPRDGDVIALIGSTRRELGGSELYRVL-GIKGGIAPRVNLEEEKGNALAI 589
+D+ + GD+I +IG + E GGSEL +++ G G AP ++L EK +
Sbjct: 564 EDVGHITTQAFKKAGDLIYVIGEAKAEFGGSELQKLVNGEISGKAPAIDLAVEKKRQEQL 623
Query: 590 LNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIIT 649
L I V HD++ GG+AVALAE VG + + F+ES R++++
Sbjct: 624 LEAIRAGAVASAHDIAEGGLAVALAESMMGEAVGADVVIDGEWTT--ELFAESQSRFLVS 681
Query: 650 LPEDK-------VEEAKEIAKIS 665
+P++K VE+A + +++
Sbjct: 682 VPKEKQAIFESLVEDAIHLGQVT 704
>pir||T51701 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) component
II [imported] - Lactococcus lactis
>gi|4097533|gb|AAD12626.1| (U64311)
phosphoribosylformylglycinamidine synthetase II
[Lactococcus lactis]
Length = 739
Score = 510 bits (1298), Expect = e-143
Identities = 289/699 (41%), Positives = 418/699 (59%), Gaps = 35/699 (5%)
Query: 14 GREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDESTWIVI 73
GR PN E M VMWSEH YK+S+ LK PT V++GPGE AGVV + +V
Sbjct: 36 GRLPNFTETGMYAVMWSEHCCYKNSKPVLKKFPTTGPQVLMGPGEGAGVVDIGDDLAVVF 95
Query: 74 GIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLFEYVV 133
ESHNHPS VEPY GAATG GGI+RDI MGARPIA+LD +RFGP++ K R++ + V
Sbjct: 96 KAESHNHPSYVEPYEGAATGSGGIIRDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVT 155
Query: 134 KGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTKPGLKLVLVG 193
GIA YGN IG+PTVGGE FDES LVNV+CVG+++ +H+ G + VG
Sbjct: 156 AGIAGYGNCIGIPTVGGEVAFDESYAGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVG 215
Query: 194 NRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAV--YTGKVKALK 251
+TGRDGIHG +FAS+E +E + RSAVQ+ DPF EKLL+EA +E + + + ++
Sbjct: 216 AKTGRDGIHGASFASKEFGSGSETQ-RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQ 274
Query: 252 DLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEPEDVE 311
D+G GL + SEMA K G G + D VP RE M P E+M+SESQERM+ V+ +
Sbjct: 275 DMGAAGLVSSTSEMASKAGSGLRLNLDNVPQRETEMIPYEMMLSESQERMVLCVKKGHEQ 334
Query: 312 ELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIE-LLTNVPTIEWPMKEYKLEE 370
E+ +F+KY+L+ +GE+ ++ + +Y KG VA +P++ L + PT +E K+ E
Sbjct: 335 EIIDLFKKYDLDAVNIGEVTDDGFYTLYHKGQMVAHVPVDSLAEDAPTY---YREAKVPE 391
Query: 371 DV-----------ETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAA 419
+ E D A+S+ F + + P I +K+ ++E YD V TVV PG DAA
Sbjct: 392 RIQKFTDSEKYLPEITDSAVSEIFKKLLAQPTIASKKSIYETYDSRVMTNTVVAPGSDAA 451
Query: 420 VLKING-EYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASP 478
VL++ G LA+T+D N Y YL+P G VAE RN+V+ G KPLA+ D LNF +P
Sbjct: 452 VLRVRGTNKALAMTTDCNARYLYLDPEKGGAIAVAEAARNIVASGGKPLAITDCLNFGNP 511
Query: 479 ERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVK-LKD 537
E+PE +W G++ + A D +SGNVS YNE + PTP++ +G ++ +K+
Sbjct: 512 EKPEQFWELTTAADGISRSCLALDTPVISGNVSLYNETNGSAILPTPMIGMVGLIEDVKN 571
Query: 538 I--PRGPRDGDVIALIGSTRRELGGSELYRVLGIKGGIAPRV--NLEEEKGNALAILNLI 593
I + GD+I L+G + GSEL ++L G I+ ++ +LE EK N +L I
Sbjct: 572 ITTQEFKKAGDLIVLVGQIFDDFSGSELQKML--TGEISGKIDFDLETEKVNQDFVLKAI 629
Query: 594 ENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITL-PE 652
+ L+ HD+S GG+A+ALAE + +G+ + S + FSE+ GR+++++ PE
Sbjct: 630 TDGLINSAHDLSEGGLAIALAESAFANGLGIDVEVDLSNAQL---FSETQGRFVLSISPE 686
Query: 653 DKVEEAKEIAKIS----IVGRVGGDNFALEVNGEKVEKD 687
++ K + + S ++G+V DN L++N + D
Sbjct: 687 NQAAFEKLLTESSASSEVIGKV-TDNGILKINELSISTD 724
>pir||S74494 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) component
II - Synechocystis sp. (strain PCC 6803)
>gi|1651718|dbj|BAA16646.1| (D90899)
phosphoribosylformyl glycinamidine synthetase II
[Synechocystis sp.]
Length = 777
Score = 503 bits (1280), Expect = e-141
Identities = 293/720 (40%), Positives = 418/720 (57%), Gaps = 50/720 (6%)
Query: 3 PREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGV 62
P E + I +RLGR PN+ E M VMWSEH YK+SR L PT+ E +++GPGE+AGV
Sbjct: 26 PEEYEDIVQRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLSNFPTEGERILVGPGENAGV 85
Query: 63 VKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEK 122
V + + IESHNHPSAVEP+ GAATG+GGI+RDI MGARPIA+L+ +RFG L+
Sbjct: 86 VDLGDGLRLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIAILNSLRFGNLDD 145
Query: 123 EKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYV 182
+NR +F VV GI+ YGN +GVPTVGGE FD + LVN + +G+M+ E +V +
Sbjct: 146 ARNRRIFTGVVDGISHYGNCVGVPTVGGEIYFDPAYSGNPLVNAMALGLMETEEIVKAGA 205
Query: 183 TKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAV 242
+ G ++ VG+ TGRDG+ G +FAS EL++ + +DR AVQ+ DPF EK LIEA LEA
Sbjct: 206 SGIGNPVLYVGSTTGRDGMGGASFASAELTDQS-MDDRPAVQVGDPFLEKSLIEACLEAF 264
Query: 243 YTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERML 302
+G V A +D+G G+TC+ +EMA K G+G + D++P+RE GM P E ++SESQERML
Sbjct: 265 KSGAVVAAQDMGAAGITCSTAEMAAKGGVGIELDLDKIPVRETGMVPYEYLLSESQERML 324
Query: 303 FAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPI------------ 350
F +P +EL IF ++ L+ V G++I +P ++++G A++P
Sbjct: 325 FVAQPGREQELIDIFHRWGLQAVVAGQVIADPIVRIFFQGGIAAEIPATALADNTPIYHR 384
Query: 351 ELLTNVPTI---EWPMKEYKLEE------DVETPDIALSKAFDLVWSSPNIVAKRWVWEQ 401
+LL P W +E L ++ + ++ + SP I +K WV+ Q
Sbjct: 385 QLLDQAPDYAQQAWQWQESDLSPAAIAGIEIAGQKQSWNEVLLTLLDSPTIASKHWVYRQ 444
Query: 402 YDHEVQGRTVVKP-GFDAAVLKING--------EYGLAITSDGNPSYCYLNPYHGAMGTV 452
YDH+VQ TV+ P G DAAV+++ G+A T+D N Y YLNP GA V
Sbjct: 445 YDHQVQNNTVIVPGGADAAVVRVRPLDAKPEECVIGVAATTDCNARYVYLNPLEGAKAAV 504
Query: 453 AEVVRNLVSVGAKPLALVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSF 512
AE RNL VGA+PLA+ DNLNF SPE P YW +G+A+ + + GNVS
Sbjct: 505 AEAARNLSCVGAEPLAVTDNLNFGSPENPVGYWQLALACEGIAEGCRQLNTPVTGGNVSL 564
Query: 513 YNEVVD-----RPVKPTPVVAGIGKVK--LKDIPRGPRD-GDVIALIGST-RRELGGSEL 563
YNE +D +P+ PTPV+ +G+V+ K + +G R+ G+ I L+GS LGGSE
Sbjct: 565 YNETLDSNGRPQPIYPTPVIGMVGRVENINKVVGQGWRNSGNGIYLLGSNDGNTLGGSEY 624
Query: 564 YRVL-GIKGGIAPRVNLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNV 622
V+ G P+V+ + EK A + I V HD + GG++VALAE++ +
Sbjct: 625 LAVVHHTVAGQPPQVDFDLEKAVQKACRHGIAQGWVNAAHDCAEGGLSVALAEMAIASQL 684
Query: 623 GVKAKFTSSFKSID-FAFSESHGRYIITL-PEDKVEEAKEIA-------KISIVGRVGGD 673
G + S + +D F ES R ++ + PE + +A K+ +VG G+
Sbjct: 685 GAEINLPDSDQRLDNLLFGESASRIVVAVAPEHQPAWENYLAGQSLPWQKLGVVGTAQGN 744
>pir||C75545 phosphoribosylformylglycinamidine synthase II - Deinococcus
radiodurans (strain R1)
>gi|6457893|gb|AAF09808.1|AE001884_3 (AE001884)
phosphoribosylformylglycinamidine synthase II
[Deinococcus radiodurans]
Length = 747
Score = 495 bits (1260), Expect = e-139
Identities = 285/688 (41%), Positives = 393/688 (56%), Gaps = 43/688 (6%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVK 64
E + +LGREPN +E A++ MWSEH YK+SR + PT V+ GPGE+AGVV
Sbjct: 19 EYDLFVSQLGREPNALEAAIVGAMWSEHCGYKNSRPLFRAFPTTGPQVLQGPGENAGVVD 78
Query: 65 FDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEK 124
+ + +ESHNHPSAVEP GAATG+GGI+RDI MGARP A+LD +RFG + +
Sbjct: 79 IGDGWGVAFKMESHNHPSAVEPVQGAATGVGGILRDIFAMGARPFAVLDSLRFGNPDSPR 138
Query: 125 NRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTK 184
R+L VV GIA YGN IGVPTVGGE F S LVNV+ +G+++ E L + +
Sbjct: 139 TRFLVNGVVDGIAHYGNAIGVPTVGGEVTFHPSYQENPLVNVMALGLLRHEDLATGTMGE 198
Query: 185 PGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYT 244
G ++V VG++TGRDG+ G F+S +LS A + DR AVQ+ DPF EKLL+EATLEA+
Sbjct: 199 VGNQIVYVGSKTGRDGLGGAVFSSADLSA-ASQADRPAVQVGDPFMEKLLLEATLEAIQA 257
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
G V ++D+G GL + EMA + LG + D+VP RE GM P+E+ +SESQERM+
Sbjct: 258 GLVAGVQDMGAAGLVSSTCEMAYRASLGITMDLDKVPTREEGMVPMELCLSESQERMILV 317
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIEWPMK 364
P + L + K+EL+ +GE+ R+ + WKG+ V DLP+ LL P
Sbjct: 318 PVPGKEQALHDLLAKWELDVVTIGEVEAHDRYRLTWKGEVVCDLPVALLNEAPKY----- 372
Query: 365 EYKLEEDVETPDIALSKAFDL---------------VWSSPNIVAKRWVWEQYDHEVQGR 409
E VE+ DI ++ DL + S P I +KR ++E+YDH+V
Sbjct: 373 ---TREGVESADIRAARERDLSGVPLPGDLGAVLLELLSHPTIASKRPIFERYDHQVMTN 429
Query: 410 TVVKPG-FDAAVLKINGE-YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPL 467
TVV PG DAAVL++ G G+A TSD NP + L+PY GA VAE RNL VGA PL
Sbjct: 430 TVVVPGAADAAVLRVKGSPMGVAATSDCNPRFVQLDPYAGAAAAVAEAARNLACVGATPL 489
Query: 468 ALVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDR----PVKP 523
A+ DNLNF +P RPEVY+ + V+G+ADA +A + GNVS YN+ + + P
Sbjct: 490 AITDNLNFGNPHRPEVYYQLQQAVQGIADACRALNTPVTGGNVSLYNQYTEGDHKVAIHP 549
Query: 524 TPVVAGIG---KVKLKDIPRGPRDGDVIALIGSTRRELGGSE-------LYRVLGIKGGI 573
TP + +G V ++ G + L+G R E G S+ L V G++ G
Sbjct: 550 TPTIGMVGVLPDVTVRASLNLKAAGQTLLLLGH-RAEKGWSDSIGASQYLETVHGLEAGQ 608
Query: 574 APRVNLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKF--TSS 631
P V+L+ + L LI L HD + GG+AVALAE++ +G+ +S
Sbjct: 609 VPPVDLDLAQKVVDGTLALIRAGLTDTAHDCAEGGLAVALAEMAIAGGLGLNVSLDAPAS 668
Query: 632 FKSIDFAFSESHGRYIITLPEDKVEEAK 659
++ F E+H R I+ + + AK
Sbjct: 669 VRADALLFGEAHSRVIVAVEDAAAAGAK 696
Score = 88.2 bits (215), Expect = 3e-16
Identities = 75/298 (25%), Positives = 128/298 (42%), Gaps = 21/298 (7%)
Query: 52 VILGPGEDAGVVKFDESTWIVIGIESHNHPSA-VEPYGGAATGIGGIVRDILCMGARPIA 110
V++ DA V++ S V N ++PY GAA + R++ C+GA P+A
Sbjct: 431 VVVPGAADAAVLRVKGSPMGVAATSDCNPRFVQLDPYAGAAAAVAEAARNLACVGATPLA 490
Query: 111 LLDPIRFGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGE-------TEFDESLDNYTL 163
+ D + FG + + Y + V+GIAD + P GG TE D + +
Sbjct: 491 ITDNLNFGNPHRPEVYYQLQQAVQGIADACRALNTPVTGGNVSLYNQYTEGDHKVAIHPT 550
Query: 164 VNVVCVGIMKPEHLVHSYVT--KPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRS 221
+ VG++ P+ V + + G L+L+G+R + + + + E +
Sbjct: 551 PTIGMVGVL-PDVTVRASLNLKAAGQTLLLLGHRAEKGWSDSI--GASQYLETVHGLEAG 607
Query: 222 AVQIPDPFTEKLLIEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVP 281
V D + +++ TL + G D GGL A +EMA GLG V
Sbjct: 608 QVPPVDLDLAQKVVDGTLALIRAGLTDTAHDCAEGGLAVALAEMAIAGGLGL-----NVS 662
Query: 282 LREPGMTPLEVMI-SESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVV 338
L P + ++ E+ R++ AVE D ++ L +AV+GE +E P+ +
Sbjct: 663 LDAPASVRADALLFGEAHSRVIVAVE--DAAAAGAKLDELGLPYAVLGETVEAPKVTI 718
>gb|AAG19309.1| (AE005026) phosphoribosylformylglycinamide synthase I; PurL
[Halobacterium sp. NRC-1]
Length = 700
Score = 486 bits (1238), Expect = e-136
Identities = 288/687 (41%), Positives = 393/687 (56%), Gaps = 29/687 (4%)
Query: 13 LGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDESTWIV 72
LGR+P E A+ E +WSEH +Y+SSR L + +E V++GPG+DA VV+ + +V
Sbjct: 15 LGRDPTPAEAALFENLWSEHCAYRSSRSLLSAFDSDSEAVVVGPGDDAAVVRVPGTDQLV 74
Query: 73 -IGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLFEY 131
+G+ESHNHPS V+PY GAATG+GGIVRD L MGA PIAL D + FG + E RYL +
Sbjct: 75 TVGVESHNHPSYVDPYDGAATGVGGIVRDTLSMGAYPIALADALYFGDFDDEHARYLLDG 134
Query: 132 VVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTKPGLKLVL 191
VV+GI+DYGN IGVPTV G T+F + LVNV CVG++ + LV + PG KLVL
Sbjct: 135 VVEGISDYGNAIGVPTVAGATQFHDGYTGNPLVNVACVGLVTEDRLVTAAAKSPGNKLVL 194
Query: 192 VGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGKVKALK 251
VGN TGRDG+ G +FASE+L+E+AE DR AVQ+ DP+TEKLLIEA + V A +
Sbjct: 195 VGNATGRDGLGGASFASEDLAEDAETADRPAVQVGDPYTEKLLIEANETLLDRDLVVAAR 254
Query: 252 DLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEPEDVE 311
DLG GL A+SEM + LGA I D V REP M +E++++ESQERM + V P DV+
Sbjct: 255 DLGAAGLGGASSEMVAQGELGARITLDAVHQREPEMNAMEILLAESQERMCYEVAPADVD 314
Query: 312 ELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTN-VPTIEWPMKEYKLEE 370
+ ++ +Y+L +V+GE + +V + G+ V D P +L + P + P
Sbjct: 315 AVREVATRYDLGCSVIGE-VTTGNYVCEFDGETVVDAPATVLADGAPATDQP-STVPQAP 372
Query: 371 DVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAVLKIN-GEYG- 428
+ PD AL A D V S+PN + WV+ QYDHEV RTV +PG DAA L ++ + G
Sbjct: 373 ATDRPDPALGTAIDAVLSAPNTASNEWVYRQYDHEVGARTVQRPGEDAAGLALHEADDGT 432
Query: 429 -LAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPERPEVYWSF 487
+A+++ NP + PY GA T E NL + GA+PLA VD LN +PE P+VY F
Sbjct: 433 TVALSAGANPGWTACQPYAGAYATAVENATNLAAAGAEPLAAVDCLNGGNPEDPDVYGGF 492
Query: 488 VETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPRG--PRDG 545
V GLAD +A D V GNVS YN+ P+ PTP +A +G +P DG
Sbjct: 493 EAMVAGLADGCRAIDTPVVGGNVSLYNDSATGPIAPTPTLAVVGYRDQHPVPGSGLAGDG 552
Query: 546 DVIALIGSTRRELGGSELYRVLG----IKGGIAPRVNLEEEKGNALAILNLIENDLVTFV 601
D++ L+G LGGS + LG A V+ E L V
Sbjct: 553 DLV-LVGGHADGLGGSVYLQALGGTDQFPAADAAGVDAVREAATRADTL---------AV 602
Query: 602 HDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYII-TLPEDKVEEAKE 660
HD+S GG+AV LAE+ V A T + + FSE GR ++ T D ++ A +
Sbjct: 603 HDISDGGLAVTLAEM-----VTADAGATVTVPGLAALFSECPGRAVVETRDADALQAALD 657
Query: 661 IAKISIVGRVGGDNFALEVNGEKVEKD 687
+ + + ++ V+ E V +D
Sbjct: 658 VPVVRLGSATTDGTLSVTVDDETVTRD 684
>emb|CAB56359.1| (AL118514) phosphoribosyl formylglycinamidine synthase II (EC
6.3.5.3) [Streptomyces coelicolor A3(2)]
Length = 752
Score = 483 bits (1231), Expect = e-135
Identities = 276/705 (39%), Positives = 403/705 (57%), Gaps = 34/705 (4%)
Query: 6 EKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTK---NEHVILGPGEDAGV 62
E+++ E LGR P E AM VMWSEH SYKSS+ L+ K ++ +++G GE+AGV
Sbjct: 33 ERVV-EILGRRPTGAELAMYSVMWSEHCSYKSSKVHLRQFGEKAPQSDAMLVGIGENAGV 91
Query: 63 VKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEK 122
V + + +ESHNHPS VEPY GAATG+GGIVRDI+ MGARP+A++DP+RFG +
Sbjct: 92 VDVGQGYAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIIAMGARPVAVVDPLRFGAADH 151
Query: 123 EKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYV 182
+ + VV GI YGN +G+P +GGE FD LVN +G+M+ E + +
Sbjct: 152 PDTKRVLPGVVAGIGGYGNCLGLPNIGGEVVFDACYQGNPLVNAGAIGVMRHEDIHLAKA 211
Query: 183 TKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAV 242
+ G K++L G RTG DGI G + + E ++A+ R AVQ+ DPF EKLLIE TLEA
Sbjct: 212 SGAGNKVILYGARTGGDGIGGASILASETFDDAKPSKRPAVQVGDPFQEKLLIECTLEAF 271
Query: 243 YTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERML 302
V ++DLG GL+CA SE+A G + D VPLR+ ++P E+++SESQERM
Sbjct: 272 AEKLVVGIQDLGAAGLSCATSELASNGSGGMRVTLDDVPLRDSTLSPEEILMSESQERMC 331
Query: 303 FAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADL-PIELLTNVPTIEW 361
VEPE V+ +I +K+++ V+GE+ + R ++W G K+ D+ P + + P E
Sbjct: 332 AVVEPEKVDRFLEICDKWDVIATVIGEVTDGDRLEIFWHGGKIVDVDPRTVAHDGPVYER 391
Query: 362 PMKEYKLEEDVE-----------TPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRT 410
P ++ ++ T D ++ LV SPN +K+W+ +QYDH VQG T
Sbjct: 392 PYARPDWQDALQADDANKLPRPGTSDELKAQVLKLV-GSPNQASKQWITQQYDHFVQGNT 450
Query: 411 VVKPGFDAAVLKINGEYGL--AITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLA 468
V+ D+ +++++ E GL AI +DGN Y L+PY GA +AE RN+ + GAKPLA
Sbjct: 451 VLAQPEDSGMIRVDEESGLGVAIATDGNGRYAKLDPYTGAQLALAEAYRNVATTGAKPLA 510
Query: 469 LVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVA 528
+ D LNF SPE P V W F E V+GLAD GNVS YN+ + + PTPVVA
Sbjct: 511 VSDCLNFGSPEDPAVMWQFAEAVRGLADGCLQLGTPVTGGNVSLYNQTGEAAIHPTPVVA 570
Query: 529 GIGKVKLKDIPRG-----PRDGDVIALIGSTRRELGGSELYRVL-GIKGGIAPRVNLEEE 582
+G + D+ R DG ++ L+G TR E GGS +V+ GG+ P+V+LE E
Sbjct: 571 VLGVI--DDVARRTPVAFQEDGQLLYLLGDTREEFGGSAWSQVIHDHLGGLPPKVDLERE 628
Query: 583 KGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSES 642
+ +++ + ++ HD+S GG+ A+ E + G + + F FSES
Sbjct: 629 RLLGEILISASRDGMIDSAHDLSDGGLVQAVVESALLGGKGARLVVPDGLDAFTFLFSES 688
Query: 643 HGRYIITLPEDKVEEAKEIA-----KISIVGRVGGDNFALEVNGE 682
GR ++ +P + ++ ++ +G V GD A+EV GE
Sbjct: 689 AGRAVVAVPRSEEVRFNDMCGARGLPVTRIGVVDGD--AVEVQGE 731
>emb|CAC12194.1| (AL445066) phosphoribosylformylglycinamidine synthase related
protein [Thermoplasma acidophilum]
Length = 759
Score = 472 bits (1202), Expect = e-132
Identities = 288/713 (40%), Positives = 410/713 (57%), Gaps = 43/713 (6%)
Query: 5 EEKIIR---ERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLK--LLPTKNEHVILGPGED 59
E K +R ERLGR+P + E + WSEH SYKSS+ +LK L K ++ IL +D
Sbjct: 31 EMKAVRSYFERLGRDPIDAEIHAVAQSWSEHCSYKSSKYYLKKYLGSLKTDYTILAMEDD 90
Query: 60 AGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGP 119
AGVV FD V+ +ESHNHPSAVEPYGGAATGIGGIVRD+LCMGA+P+AL+D + G
Sbjct: 91 AGVVDFDGEYAYVLKMESHNHPSAVEPYGGAATGIGGIVRDVLCMGAQPVALIDSLFLGD 150
Query: 120 LEKEKN------RYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMK 173
+ ++ RY+F VV GI DYGNRIG+P V G FD+ ++ LVN CVGI++
Sbjct: 151 VSSDRYEGLLSPRYIFGGVVGGIRDYGNRIGIPNVAGSLYFDKLYNSNPLVNAGCVGIVR 210
Query: 174 PEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKL 233
+ +V S KPG LVL+G +TGRDGIHGV FAS L + + R A+Q+ +P E+
Sbjct: 211 RDRIVRSKSYKPGDVLVLMGGKTGRDGIHGVNFASTTLGK-VTKSSRLAIQLGNPIVEQP 269
Query: 234 LIEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVM 293
+I+A LEA G ++A+KDLGGGGL+ AA+EM G GA I D + L+E M+ E+
Sbjct: 270 MIKAVLEANDAGLIRAMKDLGGGGLSSAATEMVYAGGFGAEITLDDIKLKESNMSGWEIW 329
Query: 294 ISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELL 353
ISESQERML PEDVE++ +I EK+ L+++V+G++ + R VY+K K+ D+ IE L
Sbjct: 330 ISESQERMLMECYPEDVEKIRQIAEKWNLDFSVIGQVTADRRIRVYYKKRKIIDMDIEFL 389
Query: 354 TNVPTIEWPMKEYKLEEDVETPDIA--LSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTV 411
+ P + P + ++E+ V P L+ + N A+ V QYDH V+G T+
Sbjct: 390 DDSPVYQRPYRIKEVEKSVTVPQEPEDLNSFVRDFMARLNTCARFNVVRQYDHTVRGSTI 449
Query: 412 VKP---------GFDAAVLK--INGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLV 460
V P DA V+K N GL +TS P+ ++PY G + T+AE +N++
Sbjct: 450 VTPFVGRPNKETHADATVIKPLENSMRGLVLTSGSRPNMVSVDPYAGTLLTLAEAYKNIL 509
Query: 461 SVGAKPLALVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRP 520
S G +P ++VD LNF +PER E+ FVE+V+ + D + L V+GNVSFYNE
Sbjct: 510 STGGRPHSVVDALNFGNPEREEIMGQFVESVRAIGDFCRKMGLPVVAGNVSFYNEYRKTD 569
Query: 521 VKPTPVVAGIGKVKLKDIPRG-----PRDGDVIALIGSTRRELGGSELYRVLGIKGGIAP 575
+ PTP + +G + D+ R G+ I LIG L GSE R+ G G P
Sbjct: 570 IMPTPTIMMVGLI--DDVRRSRTTYMKGSGNAIYLIGEPCDNLTGSEYSRMHGYTDGFLP 627
Query: 576 RVNLEEEKGNALAILNLIEN--DLVTFVHDVSRGGVAVALAELSAWFNVG--VKAKFTSS 631
+L+E I + + + D++ HDVS GG+ AL+E+S +G V S+
Sbjct: 628 APDLDE----LTRIRDFLSSKADMILSSHDVSSGGLFAALSEMSFGSGIGFHVDISNVSA 683
Query: 632 FKSIDFAFSESHGRYIITLPEDKVEEAKEIAK---ISIVGRVGGDNFALEVNG 681
+ FSE ++ + +DK E+ + + I +G GGD ++ G
Sbjct: 684 ARPTVKLFSECGNGLVLEIAKDKEEQFVDGSNGLAIKRLGETGGDRIIVDEAG 736
>dbj|BAA89451.1| (AB003162) 5'-phosphoribosyl-N-formylglycinamidine synthetase
[Corynebacterium ammoniagenes]
Length = 758
Score = 470 bits (1196), Expect = e-131
Identities = 280/696 (40%), Positives = 398/696 (56%), Gaps = 27/696 (3%)
Query: 13 LGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLL-PTKNEH----VILGPGEDAGVVKFDE 67
LGR P + E + VMWSEH SYKSS+ L+ T E ++ G GE+AGVV +
Sbjct: 38 LGRRPTDAELTVYSVMWSEHCSYKSSKTHLRYFGETTTEEMASKILAGIGENAGVVDIGD 97
Query: 68 STWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEKNRY 127
+ +ESHNHPS VEPY GAATG+GGIVRDI+ MGARPIA++D +RFGP +
Sbjct: 98 GDAVTFRVESHNHPSFVEPYQGAATGVGGIVRDIMAMGARPIAVMDQLRFGPADAPDTAR 157
Query: 128 LFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTKPGL 187
+ VV GI YGN +G+P +GGET FDES LVN +CVG ++ E L ++ + G
Sbjct: 158 VLPGVVSGIGGYGNSLGLPNIGGETVFDESYAGNPLVNALCVGTLRVEDLKLAFASGTGN 217
Query: 188 KLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGKV 247
K++L G+RTG DGI GV+ E EE AVQ+ DPF EK+LIE LE G V
Sbjct: 218 KVMLFGSRTGLDGIGGVSVLGSASFEEGEERKLPAVQVGDPFAEKVLIECCLELYAAGVV 277
Query: 248 KALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEP 307
++DLGGGGL CA SE+A G V+ D VPLR M+ E++ SESQERM V P
Sbjct: 278 VGIQDLGGGGLACATSELAAAGDGGMVVNLDNVPLRAENMSAAEILASESQERMCAVVSP 337
Query: 308 EDVEELAKIFEKYELEWAVVGEIIE-EPRFVVYWKGDKVADLPIELLTNVPTIEWPMKEY 366
++VE+ +I EK+++ A +GE+ + + ++VY G+ V D P + P E P
Sbjct: 338 DNVEKFREICEKWDVTCAEIGEVTDKKDTYLVYHNGELVVDAPPSTIDEGPVYERPYARP 397
Query: 367 KLEEDV-ETPDIA----LSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAVL 421
+ ++++ + P+IA L +AF + SSP + ++ ++ EQYD V+G TV D+ VL
Sbjct: 398 QWQDEIQQAPEIARPESLVQAFKDMVSSPALSSRAFITEQYDRYVRGNTVKAKQSDSGVL 457
Query: 422 KINGE--YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPE 479
+IN E G+AI++DG+ Y L+P GA +AE RN+ GA+P A+ + LNF SPE
Sbjct: 458 RINEETSRGVAISADGSGRYTKLDPNMGARLALAEAYRNVAVTGARPYAVTNCLNFGSPE 517
Query: 480 RPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKV-----K 534
+V W F E V GLAD +K ++ GNVSFYN+ D P+ PTPVV +G +
Sbjct: 518 NTDVMWQFREAVHGLADGSKELNIPVSGGNVSFYNQTGDEPILPTPVVGVLGVIDDVHKA 577
Query: 535 LKDIPRGPRDGDVIALIGSTRRELGGSELYRVL-GIKGGIAPRVNLEEEKGNALAILNLI 593
L G + + + L+G T+ E GGS +V G G+ P+V+L E A +
Sbjct: 578 LAHDLGGIDEPETLILLGETKEEFGGSIWQQVSGGGLQGLPPQVDLANE---AKLADFFV 634
Query: 594 ENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFK-SIDFAFSESHGRYIITLPE 652
N V HD+S GG+A+A E++ NVGV + + ++ FSES R +I+
Sbjct: 635 GNTSVAASHDLSEGGLAIAAFEMAQKNNVGVDLDLSVVHEDALTALFSESASRVLISTAS 694
Query: 653 DK----VEEAKEIAKISIVGRVGGDNFALEVNGEKV 684
D ++ A E+ ++V D+ + GE+V
Sbjct: 695 DHLDGILQRASELGIPAVVVGTTNDSGNITFAGEEV 730
>sp|P35852|PURL_LACCA PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II (FGAM SYNTHASE II)
>gi|308866|gb|AAC36947.1| (M85265)
phosphoribosylformylglycinamidine synthase II
[Lactobacillus casei]
Length = 740
Score = 465 bits (1183), Expect = e-130
Identities = 270/675 (40%), Positives = 390/675 (57%), Gaps = 21/675 (3%)
Query: 11 ERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDESTW 70
E +G +PN+ E + MWSEH +YK S+ L+ TKNE V++GPGE AGV+ E
Sbjct: 34 ELIGHQPNDTEIGLASGMWSEHCAYKYSKPVLRQFWTKNERVLMGPGEGAGVIDIGEGKA 93
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLFE 130
+V ESHNHPSAVEPY GAATG+GGI+RDI +GA+P+A+LD + FG +E+ ++L +
Sbjct: 94 VVFKAESHNHPSAVEPYEGAATGVGGIIRDIFSIGAKPVAMLDSLAFGDIEQPHTQHLVD 153
Query: 131 YVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTKPGLKLV 190
+V GI YGN IG+PTVGGET FD S LVN +CVGIM + + G L+
Sbjct: 154 RIVAGIGGYGNAIGIPTVGGETNFDGSYTRNPLVNAMCVGIMDKDQIQKGKAAGVGNALI 213
Query: 191 LVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAV--YTGKVK 248
VG +TGRDGI+G +FAS + S+ E DRSAVQ+ DPF EKLL++A LE + +
Sbjct: 214 YVGAKTGRDGINGASFASGDFSDE-EAADRSAVQVGDPFMEKLLMDACLEITGHHQEALV 272
Query: 249 ALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEPE 308
++D+G GL ++ EMAGK G V+ D +P RE MTP E+M+SESQERML V
Sbjct: 273 GIQDMGAAGLVSSSVEMAGKANSGMVLDLDLIPQREAEMTPFEIMLSESQERMLLCVRAG 332
Query: 309 DVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTI-----EWPM 363
+E+ +F Y+L+ A+VG +I ++ +Y G V D+P+ LT+ I + P
Sbjct: 333 FEQEVLAVFADYDLDAAIVGHVIAGHQYQLYHHGKLVCDVPVSSLTDDAPIYHQQGKMPK 392
Query: 364 KEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAVLKI 423
+ + D + + + + + P I K ++++YD +VQ TVV PG DAAV++I
Sbjct: 393 RLAQPAADFDPIITDPVQIWTDMMAMPTIADKSSLYKRYDAQVQTNTVVLPGSDAAVIRI 452
Query: 424 NGEY-GLAITSDGNPSYCYLNPYHGAMGTVA--EVVRNLVSVGAKPLALVDNLNFASPER 480
G + LA+T+D C L G G + RNLV+ GA+PL + D LNF P +
Sbjct: 453 RGTHRALAMTTDSKDVTCIL--IAGGCGNECWLKRARNLVASGAEPLGITDCLNFGDPTK 510
Query: 481 PEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVK-LKDIP 539
PE ++ E KG+ A KAF+ +SGNVS YNE + PTP++ +G ++ L I
Sbjct: 511 PEAFYELAEAAKGIIAATKAFNAPVISGNVSLYNETNGEAIYPTPMIGMVGLIEDLSTIT 570
Query: 540 RG--PRDGDVIALIGSTRRELGGSELYRV-LGIKGGIAPRVNLEEEKGNALAILNLIEND 596
+ D+I L+G T + GSEL ++ G G +LE EK + +L I
Sbjct: 571 TAAFKQADDLIYLVGETHGDFNGSELQKLQTGEVTGKLFDFDLEAEKQHQHFVLKAIREH 630
Query: 597 LVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITL-PEDKV 655
L+T HD+S GG+ VALAE+ +G + T + FSE+ GR+++T+ PE++
Sbjct: 631 LITAAHDLSDGGLLVALAEMGFDAQLGAQINVT---LPTAWGFSETQGRFLLTVSPENQA 687
Query: 656 EEAKEIAKISIVGRV 670
++GRV
Sbjct: 688 AFEALHGPAQLIGRV 702
>pir||JC1290 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) component
II - Lactobacillus casei
Length = 741
Score = 465 bits (1183), Expect = e-130
Identities = 270/675 (40%), Positives = 390/675 (57%), Gaps = 21/675 (3%)
Query: 11 ERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDESTW 70
E +G +PN+ E + MWSEH +YK S+ L+ TKNE V++GPGE AGV+ E
Sbjct: 34 ELIGHQPNDTEIGLASGMWSEHCAYKYSKPVLRQFWTKNERVLMGPGEGAGVIDIGEGKA 93
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLFE 130
+V ESHNHPSAVEPY GAATG+GGI+RDI +GA+P+A+LD + FG +E+ ++L +
Sbjct: 94 VVFKAESHNHPSAVEPYEGAATGVGGIIRDIFSIGAKPVAMLDSLAFGDIEQPHTQHLVD 153
Query: 131 YVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTKPGLKLV 190
+V GI YGN IG+PTVGGET FD S LVN +CVGIM + + G L+
Sbjct: 154 RIVAGIGGYGNAIGIPTVGGETNFDGSYTRNPLVNAMCVGIMDKDQIQKGKAAGVGNALI 213
Query: 191 LVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAV--YTGKVK 248
VG +TGRDGI+G +FAS + S+ E DRSAVQ+ DPF EKLL++A LE + +
Sbjct: 214 YVGAKTGRDGINGASFASGDFSDE-EAADRSAVQVGDPFMEKLLMDACLEITGHHQEALV 272
Query: 249 ALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEPE 308
++D+G GL ++ EMAGK G V+ D +P RE MTP E+M+SESQERML V
Sbjct: 273 GIQDMGAAGLVSSSVEMAGKANSGMVLDLDLIPQREAEMTPFEIMLSESQERMLLCVRAG 332
Query: 309 DVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTI-----EWPM 363
+E+ +F Y+L+ A+VG +I ++ +Y G V D+P+ LT+ I + P
Sbjct: 333 FEQEVLAVFADYDLDAAIVGHVIAGHQYQLYHHGKLVCDVPVSSLTDDAPIYHQQGKMPK 392
Query: 364 KEYKLEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAVLKI 423
+ + D + + + + + P I K ++++YD +VQ TVV PG DAAV++I
Sbjct: 393 RLAQPAADFDPIITDPVQIWTDMMAMPTIADKSSLYKRYDAQVQTNTVVLPGSDAAVIRI 452
Query: 424 NGEY-GLAITSDGNPSYCYLNPYHGAMGTVA--EVVRNLVSVGAKPLALVDNLNFASPER 480
G + LA+T+D C L G G + RNLV+ GA+PL + D LNF P +
Sbjct: 453 RGTHRALAMTTDSKDVTCIL--IAGGCGNECWLKRARNLVASGAEPLGITDCLNFGDPTK 510
Query: 481 PEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVK-LKDIP 539
PE ++ E KG+ A KAF+ +SGNVS YNE + PTP++ +G ++ L I
Sbjct: 511 PEAFYELAEAAKGIIAATKAFNAPVISGNVSLYNETNGEAIYPTPMIGMVGLIEDLSTIT 570
Query: 540 RG--PRDGDVIALIGSTRRELGGSELYRV-LGIKGGIAPRVNLEEEKGNALAILNLIEND 596
+ D+I L+G T + GSEL ++ G G +LE EK + +L I
Sbjct: 571 TAAFKQADDLIYLVGETHGDFNGSELQKLQTGEVTGKLFDFDLEAEKQHQHFVLKAIREH 630
Query: 597 LVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITL-PEDKV 655
L+T HD+S GG+ VALAE+ +G + T + FSE+ GR+++T+ PE++
Sbjct: 631 LITAAHDLSDGGLLVALAEMGFDAQLGAQINVT---LPTAWGFSETQGRFLLTVSPENQA 687
Query: 656 EEAKEIAKISIVGRV 670
++GRV
Sbjct: 688 AFEALHGPAQLIGRV 702
>gb|AAA62986.1| (U15182) phosphoribosylformylglycinamidine synthase [Mycobacterium
leprae] >gi|2076635|emb|CAB08431.1| (Z95151) PurL
[Mycobacterium leprae]
Length = 754
Score = 456 bits (1161), Expect = e-127
Identities = 268/709 (37%), Positives = 390/709 (54%), Gaps = 33/709 (4%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLL-PTKNEHV----ILGPGED 59
E + +RE LGR P + E AM VMWSEH SYKSS+ L+ T E + + G GE+
Sbjct: 27 EYQRVREILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTTEEMRTGMLAGIGEN 86
Query: 60 AGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGP 119
AGVV + + +ESHNHPS VEPY GAATG+GGIVRDI+ MGARP+A++D +RFG
Sbjct: 87 AGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGA 146
Query: 120 LEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVH 179
+ R + + VV+GI YGN +G+P +GGET FD D LVN +CVG+++ E L
Sbjct: 147 ADALDTRRVLDGVVRGIGGYGNSLGLPNIGGETVFDSCYDGNPLVNALCVGVLRQEDLHL 206
Query: 180 SYVTKPGLKLVLVGNRTGRDGIHGVT-FASEELSENAEEEDRSAVQIPDPFTEKLLIEAT 238
++ + G K++L G TG DGI GV+ AS+ + +VQ+ DPF EK+LIE
Sbjct: 207 AFASGAGNKIILFGACTGLDGIGGVSVLASDTFDAEGARKKLPSVQVGDPFMEKVLIECC 266
Query: 239 LEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQ 298
LE G V ++DLGG GL+CA SE+A +G I D VP R MTP EV SESQ
Sbjct: 267 LELYAGGLVIGIQDLGGAGLSCATSELASAGDVGMAIQLDTVPRRAKDMTPAEVFCSESQ 326
Query: 299 ERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNV-P 357
ERM V PE+V+ + K+E+ V+GE+ + R + W G+ V D+P + + P
Sbjct: 327 ERMCAVVAPENVDAFLAVCRKWEVLATVIGEVTDGDRLRITWHGETVVDVPPRTVAHEGP 386
Query: 358 TIEWPMKEYKLEEDVETPDI----------ALSKAFDLVWSSPNIVAKRWVWEQYDHEVQ 407
+ P+ + +E + L + SP++ ++ ++ EQYD V+
Sbjct: 387 VYQRPVSRPESQEALNADSSKGLPRPVSGDELRATLLALLGSPHLCSRAFITEQYDRYVR 446
Query: 408 GRTVVKPGFDAAVLKINGE--YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAK 465
G TV+ DA VL+I+ G+A+++D + Y L+PY GA +AE RN+ GA
Sbjct: 447 GNTVLAEHADAGVLRIDESTGRGIALSTDASGRYTRLDPYAGAQLALAEAYRNVAVTGAT 506
Query: 466 PLALVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTP 525
P+A+ + LNF SPE P V W F + V+GLAD A + GNVSFYN+ + PTP
Sbjct: 507 PVAVTNCLNFGSPEDPGVMWQFAQAVRGLADGCAALKIPVTGGNVSFYNQTGAVAILPTP 566
Query: 526 VVAGIGKVKLKDIPR------GPRDGDVIALIGSTRRELGGSELYRVL-GIKGGIAPRVN 578
VV +G L ++ R G G+++ L+G T E GS +V+ G GG+ P V+
Sbjct: 567 VVGVLG--VLDNVARRIHTSLGTEPGEILMLLGDTYDEFDGSVWAQVMAGHLGGLPPMVD 624
Query: 579 LEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFA 638
L EK A + + ++LV+ HD+S GG+A A+ E + G +
Sbjct: 625 LAREKLLAEVLSSASRDELVSAAHDLSEGGLAQAIVESALAGETGCRIALPEDADPFVML 684
Query: 639 FSESHGRYIITLPEDKVEEAKEIAK-----ISIVGRVGGDNFALEVNGE 682
FSES GR ++ +P + + + + +G V + ++EV G+
Sbjct: 685 FSESAGRVLVAVPRPEESRFRSMCEARGLPAMRIGVVDQGSDSIEVRGQ 733
>sp|P54876|PURL_MYCTU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II (FGAM SYNTHASE II)
>gi|7438072|pir||D70536 probable purL protein -
Mycobacterium tuberculosis (strain H37RV)
>gi|3261789|emb|CAB09108.1| (Z95618) purL [Mycobacterium
tuberculosis]
Length = 754
Score = 452 bits (1150), Expect = e-126
Identities = 269/709 (37%), Positives = 388/709 (53%), Gaps = 35/709 (4%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLL--PTKNEH---VILGPGED 59
E + IR+ LGR P + E AM VMWSEH SYKSS+ L+ T +E ++ G GE+
Sbjct: 27 EYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTSDEMRAAMLAGIGEN 86
Query: 60 AGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGP 119
AGVV + + +ESHNHPS VEPY GAATG+GGIVRDI+ MGARP+A++D +RFG
Sbjct: 87 AGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGA 146
Query: 120 LEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVH 179
+ R + + VV+GI YGN +G+P +GGET FD LVN +CVG+++ E L
Sbjct: 147 ADAPDTRRVLDGVVRGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQEDLHL 206
Query: 180 SYVTKPGLKLVLVGNRTGRDGIHGVT-FASEELSENAEEEDRSAVQIPDPFTEKLLIEAT 238
++ + G K++L G RTG DGI GV+ AS+ + +VQ+ DPF EK+LIE
Sbjct: 207 AFASGAGNKIILFGARTGLDGIGGVSVLASDTFDAEGSRKKLPSVQVGDPFMEKVLIECC 266
Query: 239 LEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQ 298
LE G V ++DLGG GL+CA SE+A G I D VPLR MTP EV+ SESQ
Sbjct: 267 LELYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQ 326
Query: 299 ERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNV-P 357
ERM V P++V+ + K+E+ V+GE+ + R + W G+ V D+P + + P
Sbjct: 327 ERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGP 386
Query: 358 TIEWPMKEYKLEEDVETPDIA----------LSKAFDLVWSSPNIVAKRWVWEQYDHEVQ 407
+ P+ ++ + A L + SP++ ++ ++ EQYD V+
Sbjct: 387 VYQRPVARPDTQDALNADRSAKLSRPVTGDELRATLLALLGSPHLCSRAFITEQYDRYVR 446
Query: 408 GRTVVKPGFDAAVLKINGE--YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAK 465
G TV+ D +L+I+ G+A+++D + Y L+PY GA +AE RN+ GA
Sbjct: 447 GNTVLAEHADGGMLRIDESTGRGIAVSTDASGRYTLLDPYAGAQLALAEAYRNVAVTGAT 506
Query: 466 PLALVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTP 525
P+A+ + LNF SPE P V W F + V+GLAD + GNVSFYN+ + PTP
Sbjct: 507 PVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTGSAAILPTP 566
Query: 526 VVAGIGKVKLKDIPR------GPRDGDVIALIGSTRRELGGSELYRVLGIK-GGIAPRVN 578
VV +G + D+ R G G+ + L+G TR E GS +V GG+ P V+
Sbjct: 567 VVGVLGVI--DDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTADHLGGLPPVVD 624
Query: 579 LEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFA 638
L EK A + + + LV+ HD+S GG+A A+ E + G +
Sbjct: 625 LAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPEGADPFVLL 684
Query: 639 FSESHGRYIITLPEDKVE------EAKEIAKISIVGRVGGDNFALEVNG 681
FSES GR ++ +P + EA+ + + I G V + A+EV G
Sbjct: 685 FSESAGRVLVAVPRTEESRFRGMCEARGLPAVRI-GVVDQGSDAVEVQG 732
>gb|AAB41455.1| (U34956) phosphoribosylformylglycinamidine synthase [Mycobacterium
tuberculosis]
Length = 754
Score = 447 bits (1137), Expect = e-124
Identities = 267/709 (37%), Positives = 386/709 (53%), Gaps = 35/709 (4%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLL--PTKNEH---VILGPGED 59
E + IR+ L R P + E AM VMWSEH SYKSS L+ T +E +++G GE+
Sbjct: 27 EYRRIRQILDRRPTDTELAMYSVMWSEHCSYKSSAVHLRYFGETTSDEMRAVMLVGIGEN 86
Query: 60 AGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGP 119
AGVV + + +ESHNHPS VEPY GA TG+GGIVRDI+ MGARP+A++D +RFG
Sbjct: 87 AGVVDIGDGWAVTFKVESHNHPSYVEPYQGAPTGVGGIVRDIMAMGARPVAVMDQLRFGA 146
Query: 120 LEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVH 179
+ R + + VV+GI YGN +G+P +GGET FD LVN +CVG+++ E L
Sbjct: 147 ADAPDTRRVLDGVVRGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQEDLHL 206
Query: 180 SYVTKPGLKLVLVGNRTGRDGIHGVT-FASEELSENAEEEDRSAVQIPDPFTEKLLIEAT 238
++ + G K++L G RTG DGI GV+ AS+ + +VQ+ DPF EK+LIE
Sbjct: 207 AFASGAGNKIILFGARTGLDGIGGVSVLASDTFDAEGSRKKLPSVQVGDPFMEKVLIECC 266
Query: 239 LEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQ 298
LE G V ++DLGG GL+CA SE+A G I D VPLR MTP EV+ SESQ
Sbjct: 267 LELYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQ 326
Query: 299 ERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNV-P 357
ERM V P++V+ + K+E+ V+GE+ + R + W G+ V D+P + + P
Sbjct: 327 ERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGP 386
Query: 358 TIEWPMKEYKLEEDVETPDIA----------LSKAFDLVWSSPNIVAKRWVWEQYDHEVQ 407
+ P+ ++ + A L + SP++ ++ ++ EQYD V+
Sbjct: 387 VYQRPVARPDTQDALNADRSAKLSRPVTGDELRATLLALLGSPHLCSRAFITEQYDRYVR 446
Query: 408 GRTVVKPGFDAAVLKINGE--YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAK 465
G TV+ D +L+I+ G+A+++D + Y L+PY GA +AE RN+ GA
Sbjct: 447 GNTVLAEHADGGMLRIDESTGRGIAVSTDASGRYTLLDPYAGAQLALAEAYRNVAVTGAT 506
Query: 466 PLALVDNLNFASPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTP 525
P+A+ + LNF SPE P V W F + V+GLAD + GNVSFYN+ + PTP
Sbjct: 507 PVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTGSAAILPTP 566
Query: 526 VVAGIGKVKLKDIPR------GPRDGDVIALIGSTRRELGGSELYRVLGIK-GGIAPRVN 578
VV +G + D+ R G G+ + L+G TR E GS +V GG+ P V+
Sbjct: 567 VVGVLGVI--DDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTADHLGGLPPVVD 624
Query: 579 LEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFA 638
L EK A + + + LV+ HD+S GG+A A+ E + G +
Sbjct: 625 LAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPEGADPFVLL 684
Query: 639 FSESHGRYIITLPEDKVE------EAKEIAKISIVGRVGGDNFALEVNG 681
FSES GR ++ +P + EA+ + + I G V + A+EV G
Sbjct: 685 FSESAGRVLVAVPRTEESRFRGMCEARGLPAVRI-GVVDQGSDAVEVQG 732
>pir||B81370 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) Cj0955c
[imported] - Campylobacter jejuni (strain NCTC 11168)
>gi|6968392|emb|CAB73212.1| (AL139076)
phosphoribosylformylglycinamidine synthase
[Campylobacter jejuni]
Length = 728
Score = 432 bits (1100), Expect = e-120
Identities = 262/712 (36%), Positives = 400/712 (55%), Gaps = 34/712 (4%)
Query: 9 IRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDES 68
I E LGREPN +E ++ MWSEH SYKSS+K+L PTK VI GPGE+AGV+ +
Sbjct: 19 ILEILGREPNLLELGVISAMWSEHCSYKSSKKYLNGFPTKAPWVIQGPGENAGVIDIGQG 78
Query: 69 TWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEK---- 124
V +ESHNHPS +EP+ GAATG+GGI+RD+ MGAR +A L+ ++FG + EK
Sbjct: 79 MAAVFKVESHNHPSFIEPFAGAATGVGGILRDVFTMGARVVAGLNSLKFGDIHDEKCGKH 138
Query: 125 NRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTK 184
+YL + VV GI+ YGN +GVPT+GGE FDE + LVN +G+ K E + ++
Sbjct: 139 QKYLVKGVVNGISHYGNCMGVPTIGGECAFDECFNGNILVNAFALGVCKSEDIFYAKAEG 198
Query: 185 PGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYT 244
G ++ VG++TGRDG+ G AS+ +E ++ R VQI DPF+EKLL+EA LE T
Sbjct: 199 VGNPVIYVGSKTGRDGLGGAVMASDSFNEESKSL-RPTVQIGDPFSEKLLMEACLELFKT 257
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+ ++D+G GLT ++ EMAG+ G G +Y D+ P+RE GMTP E+M+SESQERML
Sbjct: 258 DYIVGIQDMGAAGLTSSSFEMAGRSGSGMKLYLDKTPMRESGMTPYELMLSESQERMLIC 317
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLT-NVPTIEWPM 363
+ +++ +IF+K++L+ V+GE+ + ++W + V +PIE L+ P + P
Sbjct: 318 AKKGYEDKVIEIFKKWDLDAVVMGEVTNTGKMELFWHDELVGLIPIEPLSEKAPILSRPT 377
Query: 364 KEYKLEEDVETPDIALSKA----FDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPG-FDA 418
E K +++ L + F + + NI K ++++Q+D VQ T+ G A
Sbjct: 378 SEPKYLSEIKNYKFELKSSVQELFIQMLQNENINNKAFIYDQFDSSVQTNTIKADGRLGA 437
Query: 419 AVLKI--NGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFA 476
+V++I NG +A+ + N Y+N GA VA R + GAKPLA+ D LN+
Sbjct: 438 SVIRIKENGA-SVAMAIECNSRLNYVNSKIGAALAVASAGRKVACTGAKPLAISDCLNYG 496
Query: 477 SPERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLK 536
+P+ PEV W F + +G+ +A K + VSGNVS YNE + P+P + +G L+
Sbjct: 497 NPQNPEVMWQFAQGCEGIKEACKELNTPVVSGNVSLYNETEGVSIYPSPTIVSVG--VLE 554
Query: 537 DIPRG-----PRDGDVIALIGSTRRELGGSELYRVLGIK-GGIAPRVNLEEEKGNALAIL 590
D + ++ + L+G + E GS + ++ K G ++ + E LA+
Sbjct: 555 DANKTLKASFEKENLSVYLLGESLGEFSGSMVMKIQDKKVSGSLKELDYKAE----LALW 610
Query: 591 NLI----ENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRY 646
+L+ +N L+ + V GG+A+ LA++ A +VG A TS F F ES R
Sbjct: 611 DLLYKANQNSLLECANSVGIGGIAMTLAKMFAISSVG--ANLTSDFDDEKMIFDESASRA 668
Query: 647 IITLPEDKVEEAKEIAKISIVG--RVGGDNFALEVNGEKVEKDIEELSRIYW 696
II L ++ E +AK V ++G + +E EL ++Y+
Sbjct: 669 IIGLSKENEEAFLNLAKEFGVKAYKLGVSTSQKHFKLDSIELSKAELDKLYF 720
>pir||H72276 phosphoribosylformylglycinamidine synthase II - Thermotoga maritima
(strain MSB8) >gi|4981801|gb|AAD36321.1|AE001780_5
(AE001780) phosphoribosylformylglycinamidine synthase II
[Thermotoga maritima]
Length = 603
Score = 394 bits (1002), Expect = e-108
Identities = 222/543 (40%), Positives = 317/543 (57%), Gaps = 32/543 (5%)
Query: 8 IIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDE 67
I++E+LGREP VE VMWSEH Y ++K+++ LP G +AGVV D+
Sbjct: 8 ILKEKLGREPTFVELQAFSVMWSEHCGYSHTKKYIRRLPKT------GFEGNAGVVNLDD 61
Query: 68 STWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEKNRY 127
+ IESHNHPSA+EPY GAATG+GGI+RD+L MGARP A+ D + +
Sbjct: 62 YYSVAFKIESHNHPSAIEPYNGAATGVGGIIRDVLAMGARPTAIFDSLHMSRI------- 114
Query: 128 LFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEHLVHSYVTKPGL 187
+ +++GIADYGN IGVPTVGGE + LVNV+ G+++ + LV S ++PG
Sbjct: 115 -IDGIIEGIADYGNSIGVPTVGGELRISSLYAHNPLVNVLAAGVVRNDMLVDSKASRPGQ 173
Query: 188 KLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGKV 247
+V+ G TGRDGIHG +FASE+L+ ++ + ++Q+ DPF EK+LIEA LE V G V
Sbjct: 174 VIVIFGGATGRDGIHGASFASEDLT--GDKATKLSIQVGDPFAEKMLIEAFLEMVEEGLV 231
Query: 248 KALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEP 307
+ +DLG GG+ A SE+ K LGA+++ DRVPLREP M P E++ISESQERM P
Sbjct: 232 EGAQDLGAGGVLSATSELVAKGNLGAIVHLDRVPLREPDMEPWEILISESQERMAVVTSP 291
Query: 308 EDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIEWPMKEYK 367
+ + +I K+ L VV E+IEEP + V ++ D V ++P++LL N P E + EY
Sbjct: 292 QKASRILEIARKHLLFGDVVAEVIEEPVYRVMYRNDLVMEVPVQLLANAP--EEDIVEYT 349
Query: 368 LEEDVETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGFDAAVLKINGEY 427
+ E + + V R V+EQYDH V TVV PGF AAV++I +
Sbjct: 350 PGKIPEFKRVEFEE-----------VNAREVFEQYDHMVGTDTVVPPGFGAAVMRIKRDG 398
Query: 428 GLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPERPEVYWSF 487
G ++ + + Y G + V E VR +SVGA+PLA+ + +N+ P+ V S
Sbjct: 399 GYSLVTHSRADLALQDTYWGTLIAVLESVRKTLSVGAEPLAITNCVNYGDPDVDPVGLSA 458
Query: 488 VETVKGLADAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPRGPRDGDV 547
+ T L +A + + SGN S YN +P+ PT VV +GKV + + + P+ V
Sbjct: 459 MMT--ALKNACEFSGVPVASGNASLYNTYQGKPIPPTLVVGMLGKVNPQKVAK-PKPSKV 515
Query: 548 IAL 550
A+
Sbjct: 516 FAV 518
>emb|CAA04218.1| (AJ000662) PurL protein [Wolinella succinogenes]
Length = 331
Score = 189 bits (476), Expect = 7e-47
Identities = 119/328 (36%), Positives = 182/328 (55%), Gaps = 22/328 (6%)
Query: 381 KAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGF-DAAVLKI--NGEYGLAITSDGNP 437
+AF +WS+P + K WV+ QYD VQ T+V PG D +++++ NG LA+++D NP
Sbjct: 2 EAFMKLWSAPETMDKSWVYSQYDSMVQTNTIVGPGGGDGSLVRVKENGA-ALAMSADCNP 60
Query: 438 SYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPERPEVYWSFVETVKGLADA 497
YCYLNP GA VAE RN+ GA+PLA+ D LNF SPE PEV W F E +G+ +A
Sbjct: 61 RYCYLNPREGAKLAVAESGRNVAVRGARPLAITDCLNFGSPENPEVMWQFAEACEGIKEA 120
Query: 498 AKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIG---KVKLKDIPRGPRDGDVIALIGST 554
K VSGNVS YN+ + PTP +A +G K + + ++G+++ L+G T
Sbjct: 121 CKVLLTPVVSGNVSLYNQTNGVDIFPTPSIATVGLLPKAQKALLGAFKKEGNLLLLVGET 180
Query: 555 RRELGGSELYR--VLGIKGGIAPRVNLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVA 612
+ E GGS LY+ V G GG AP ++L E + E + DV+ GG+A+A
Sbjct: 181 KSEFGGS-LYQKEVEGFLGGDAPVIDLHRELALWRFLEEANEAGFLESAKDVNVGGLAIA 239
Query: 613 LAELSAWFNVGVKAKFTSSFKSIDFAFSESHGRYIITLPEDKVEEAKEIAK-----ISIV 667
L ++S G K K ++ K +D FSES R ++ + + + + +A+ + ++
Sbjct: 240 LGKMSVLGQKGCKVK--TALKGVDL-FSESPSRAVLEVSSEHLAALESLAQKGGVALGVI 296
Query: 668 GRVGGDNFALEVNGEKVEKDIEELSRIY 695
G VGG+N + + + ++ L IY
Sbjct: 297 GSVGGENLEI----DSLSLPLQTLQEIY 320
>sp|P26500|PURL_METTM PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II (FGAM SYNTHASE II)
>gi|80923|pir||C40398 phosphoribosylformylglycinamidine
synthase (EC 6.3.5.3) component II - Methanobacterium
thermoautotrophicum (strain Marburg) (fragment)
>gi|551892|gb|AAA72951.1| (M59245) formylglycineamidine
ribonucleotide synthase [Methanobacterium
thermoautotrophicum]
Length = 129
Score = 164 bits (411), Expect = 3e-39
Identities = 79/123 (64%), Positives = 97/123 (78%)
Query: 5 EEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGVVK 64
E + IR+ LGR+PN +E ML+VM+SEH SYKSSR L PT+ E VI+GPG+DAGVV+
Sbjct: 7 EIEFIRKELGRDPNPLEYGMLDVMFSEHCSYKSSRPVLGFFPTEGEGVIIGPGDDAGVVE 66
Query: 65 FDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPIRFGPLEKEK 124
+ + IGIESHNHPSA+EPYGGA TGIGGI+RDI+ MGA PIALLD +RFG LE +K
Sbjct: 67 VTDELAMAIGIESHNHPSAIEPYGGAGTGIGGILRDIISMGAMPIALLDSLRFGYLEDQK 126
Query: 125 NRY 127
+RY
Sbjct: 127 SRY 129
>sp|P15254|PURL_ECOLI PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (FGAM SYNTHASE)
(FORMYLGLYCINAMIDE RIBOTIDE AMIDOTRANSFERASE) (FGARAT)
>gi|147423|gb|AAA24456.1| (M19501) formylglycineamide
ribonucleotide synthetase (EC 6.3.5.3) [Escherichia
coli] >gi|1033146|gb|AAA79819.1| (U36841)
phosphoribosylformylglycineamide synthetase [Escherichia
coli]
Length = 1295
Score = 129 bits (320), Expect = 1e-28
Identities = 187/794 (23%), Positives = 325/794 (40%), Gaps = 113/794 (14%)
Query: 12 RLGREPNEVEKAMLEVMWSEHVSYK---------------SSRKWLK-LLPTKNEHVILG 55
+LGR PN++E M SEH +K S K +K T +HV+
Sbjct: 196 KLGRNPNDIELYMFAQANSEHCRHKIFNADWVIDGEQQPKSLFKMIKNTFETTPDHVLSA 255
Query: 56 PGEDAGVVK------------------FDESTWIVIGIESHNHPSAVEPYGGAATGIGGI 97
++A V++ E I++ +E+HNHP+A+ P+ GAATG GG
Sbjct: 256 YKDNAAVMEGSEVGRYFADHETGRYDFHQEPAHILMKVETHNHPTAISPWPGAATGSGGE 315
Query: 98 VRD--ILCMGARPIALL-----DPIRFGPLEK--EKNRYLFEYVVKGI----------AD 138
+RD GA+P A L +R E+ E++ E +V + A
Sbjct: 316 IRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAA 375
Query: 139 YGNRIGVPTVGGETE-FDESLDNYT----------LVNVVCVGIMKPEHLVHSYVTKPGL 187
+ N G P + G ++E ++++ ++ +G ++ +H+ + G
Sbjct: 376 FNNEFGRPALNGYFRTYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEINV-GA 434
Query: 188 KLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKL---LIEATLEAVYT 244
KLV++G G+ G +S ++ + D ++VQ +P E+ +I+ +
Sbjct: 435 KLVVLGGPAMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGDA 494
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+ + D+G GGL+ A E+ G G + EPGM+PLE+ +ESQER + A
Sbjct: 495 NPILFIHDVGAGGLSNAMPELVSDGGRGGKFELREILSDEPGMSPLEIWCNESQERYVLA 554
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWK--GDKVADLPIE-LLTNVPTIEW 361
V + + ++ ++ +AV+GE EE ++ + ++ DLP++ LL P +
Sbjct: 555 VAADQLPLFDELCKRERAPYAVIGEATEELHLSLHDRHFDNQPIDLPLDVLLGKTPKMTR 614
Query: 362 PMKEYKLEED-VETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTV--------V 412
++ K + D + I ++ A V P + K ++ D V G
Sbjct: 615 DVQTLKAKGDALAREGITIADAVKRVLHLPTVAEKTFLVTIGDRSVTGMVARDQMVGPWQ 674
Query: 413 KPGFDAAV--LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSV---GAKPL 467
P + AV ++ YG A+ L+ A V E + N+ + K +
Sbjct: 675 VPVANCAVTTASLDSYYGEAMAIGERAPVALLDFAASARLAVGEALTNIAATQIGDIKRI 734
Query: 468 ALVDNLNFASPERPEVYWSFVETVKGLA-DAAKAFDLAYVSGNVSF-----YNEVVDRPV 521
L N A+ P E VK + + A L G S + E +
Sbjct: 735 KLSANW-MAAAGHPGEDAGLYEAVKAVGEELCPALGLTIPVGKDSMSMKTRWQEGNEERE 793
Query: 522 KPTPV------VAGIGKVKLKDIPRGPRDGDVIALI--GSTRRELGG---SELYRVLGIK 570
+P+ A + V+ P+ + + + LI G LG +++YR LG K
Sbjct: 794 MTSPLSLVISAFARVEDVRHTITPQLSTEDNALLLIDLGKGNNALGATALAQVYRQLGDK 853
Query: 571 GGIAPRVNLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKF-T 629
A ++ + KG AI L+ + HD S GG+ V LAE++ + G+ A T
Sbjct: 854 P--ADVRDVAQLKGFYDAIQALVAQRKLLAYHDRSDGGLLVTLAEMAFAGHCGIDADIAT 911
Query: 630 SSFKSIDFAFSESHGRYIITLPEDKVEEAKEIAK------ISIVGR-VGGDNFALEVNGE 682
+ F+E G I D+ +A+ + VG+ V GD F + NG+
Sbjct: 912 LGDDRLAALFNEELGAVIQVRAADREAVESVLAQHGLADCVHYVGQAVSGDRFVITANGQ 971
Query: 683 KVEKDIEELSRIYW 696
V + R++W
Sbjct: 972 TVFSESRTTLRVWW 985
>pir||G81961 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) NMA0445
[imported] - Neisseria meningitidis (group A strain
Z2491) >gi|7379194|emb|CAB83743.1| (AL162753)
phophoribosylformylglycinamidine synthase [Neisseria
meningitidis Z2491]
Length = 1320
Score = 128 bits (318), Expect = 2e-28
Identities = 160/655 (24%), Positives = 268/655 (40%), Gaps = 83/655 (12%)
Query: 33 VSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDESTWIVIGIESHNHPSAVEPYGGAAT 92
V+YK + ++ K E E+ G +E T I++ +E+HNHP+A+ P+ GAAT
Sbjct: 257 VAYKDNSSVIE--GAKVERFYPNAAENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAAT 314
Query: 93 GIGGIVRD--ILCMGARPIALLDPIRFG---------PLEKEKNR---------YLFEYV 132
G GG +RD G+RP A L P E++ + + E
Sbjct: 315 GAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPGLKQPWEQDYGKPEHISSPLDIMIEGP 374
Query: 133 VKGIADYGNRIGVPTVGG-----ETEFDESLDNYTLVNVVCVGIMKPE-HLVHSYVTKPG 186
+ G A + N G P + G E +FD + Y ++ G+ + H G
Sbjct: 375 IGGAA-FNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEG 433
Query: 187 LKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGK 246
L+ +G G+ G +S + N D ++VQ +P E+ E G
Sbjct: 434 ALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGD 493
Query: 247 ---VKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLF 303
+ ++ D+G GGL+ A E+ G GAV VPL E G+ PL++ +ESQER +
Sbjct: 494 KNPIISIHDVGAGGLSNAFPELVNDAGRGAVFKLREVPLEEHGLNPLQIWCNESQERYVL 553
Query: 304 AVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIEWPM 363
++ +D++ I E+ +AVVG ++ V + D ++ P++L NV + P
Sbjct: 554 SILEKDLDIFRSICERERCPFAVVGTATDDGHLKV--RDDLFSNNPVDLPLNV-LLGKPP 610
Query: 364 KEYKLEEDV-------ETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRT------ 410
K + ++ V DI +++A V P + AK ++ D V G T
Sbjct: 611 KTTRTDKTVAPSKKPFHAGDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGMTHRDQMV 670
Query: 411 --VVKPGFDAAV--LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKP 466
P D AV + N G A++ P+ + V E + N + A
Sbjct: 671 GKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITN---IAAAN 727
Query: 467 LALVDNLNFAS---------PERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVV 517
+ + N+ ++ E ++Y TV+ ++ A +A DL+ G S + V
Sbjct: 728 IGDIGNIKLSANWMAACGNEGEDEKLY----RTVEAVSKACQALDLSIPVGKDSLSMKTV 783
Query: 518 -------DRPVKPTPVV----AGIGKVKLKDIPRGPRDGDVIAL---IGSTRRELGGSEL 563
V P ++ A + V+ P D + L +G + +GGS
Sbjct: 784 WQDGEEKKSVVSPLSLIISAFAPVQDVRKTVTPELKNVEDSVLLFVDLGFGKARMGGSAF 843
Query: 564 YRVLGIKGGIAPRV-NLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELS 617
+V G AP + + K I L+ D + HD S GG+ L E++
Sbjct: 844 GQVYNNMSGDAPDLDDTSRLKAFYNVIQQLVAEDKLLAYHDRSDGGLFAVLVEMA 898
>pir||SYECPG phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) [validated]
- Escherichia coli >gi|1788909|gb|AAC75610.1| (AE000342)
phosphoribosylformyl-glycineamide synthetase = FGAM
synthetase [Escherichia coli K12]
Length = 1295
Score = 127 bits (316), Expect = 4e-28
Identities = 186/794 (23%), Positives = 325/794 (40%), Gaps = 113/794 (14%)
Query: 12 RLGREPNEVEKAMLEVMWSEHVSYK---------------SSRKWLK-LLPTKNEHVILG 55
+LGR PN++E M SEH +K S K +K T +HV+
Sbjct: 196 KLGRNPNDIELYMFAQANSEHCRHKIFNADWVIDGEQQPKSLFKMIKNTFETTPDHVLSA 255
Query: 56 PGEDAGVVK------------------FDESTWIVIGIESHNHPSAVEPYGGAATGIGGI 97
++A V++ E I++ +E+HNHP+A+ P+ GAATG GG
Sbjct: 256 YKDNAAVMEGSEVGRYFADHETGRYDFHQEPAHILMKVETHNHPTAISPWPGAATGSGGE 315
Query: 98 VRD--ILCMGARPIALL-----DPIRFGPLEK--EKNRYLFEYVVKGI----------AD 138
+RD GA+P A L +R E+ E++ E +V + A
Sbjct: 316 IRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAA 375
Query: 139 YGNRIGVPTVGGETE-FDESLDNYT----------LVNVVCVGIMKPEHLVHSYVTKPGL 187
+ N G P + G ++E ++++ ++ +G ++ +H+ + G
Sbjct: 376 FNNEFGRPALNGYFRTYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEINV-GA 434
Query: 188 KLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKL---LIEATLEAVYT 244
KLV++G G+ G +S ++ + D ++VQ +P E+ +I+ +
Sbjct: 435 KLVVLGGPAMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGDA 494
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+ + D+G GGL+ A E+ G G + EPGM+PLE+ +ESQER + A
Sbjct: 495 NPILFIHDVGAGGLSNAMPELVSDGGRGGKFELREILSDEPGMSPLEIWCNESQERYVLA 554
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWK--GDKVADLPIE-LLTNVPTIEW 361
V + + ++ ++ +AV+GE EE ++ + ++ DLP++ LL P +
Sbjct: 555 VAADQLPLFDELCKRERAPYAVIGEATEELHLSLHDRHFDNQPIDLPLDVLLGKTPKMTR 614
Query: 362 PMKEYKLEED-VETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTV--------V 412
++ K + D + I ++ A V P + K ++ D V G
Sbjct: 615 DVQTLKAKGDALAREGITIADAVKRVLHLPTVAEKTFLVTIGDRSVTGMVARDQMVGPWQ 674
Query: 413 KPGFDAAV--LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSV---GAKPL 467
P + AV ++ YG A+ L+ A V E + N+ + K +
Sbjct: 675 VPVANCAVTTASLDSYYGEAMAIGERAPVALLDFAASARLAVGEALTNIAATQIGDIKRI 734
Query: 468 ALVDNLNFASPERPEVYWSFVETVKGLA-DAAKAFDLAYVSGNVSF-----YNEVVDRPV 521
L N A+ P E VK + + A L G S + E +
Sbjct: 735 KLSANW-MAAAGHPGEDAGLYEAVKAVGEELCPALGLTIPVGKDSMSMKTRWQEGNEERE 793
Query: 522 KPTPV------VAGIGKVKLKDIPRGPRDGDVIALI--GSTRRELGG---SELYRVLGIK 570
+P+ A + V+ P+ + + + LI G LG ++++R LG K
Sbjct: 794 MTSPLSLVISAFARVEDVRHTITPQLSTEDNALLLIDLGKGNNALGATALAQVFRQLGDK 853
Query: 571 GGIAPRVNLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKF-T 629
A ++ + KG AI L+ + HD S GG+ V LAE++ + G+ A T
Sbjct: 854 P--ADVRDVAQLKGFYDAIQALVAQRKLLAYHDRSDGGLLVTLAEMAFAGHCGIDADIAT 911
Query: 630 SSFKSIDFAFSESHGRYIITLPEDKVEEAKEIAK------ISIVGR-VGGDNFALEVNGE 682
+ F+E G I D+ +A+ + VG+ V GD F + NG+
Sbjct: 912 LGDDRLAALFNEELGAVIQVRAADREAVESVLAQHGLADCVHYVGQAVSGDRFVITANGQ 971
Query: 683 KVEKDIEELSRIYW 696
V + R++W
Sbjct: 972 TVFSESRTTLRVWW 985
>pir||G81017 phosphoribosylformylglycinamidine synthase NMB1996 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7227259|gb|AAF42323.1| (AE002549)
phosphoribosylformylglycinamidine synthase [Neisseria
meningitidis MC58]
Length = 1320
Score = 127 bits (315), Expect = 5e-28
Identities = 163/656 (24%), Positives = 274/656 (40%), Gaps = 85/656 (12%)
Query: 33 VSYKSSRKWLKLLPTKNEHVILGPGEDAGVVKFDESTWIVIGIESHNHPSAVEPYGGAAT 92
V+YK + ++ K E E+ G +E T I++ +E+HNHP+A+ P+ GAAT
Sbjct: 257 VAYKDNSSVIE--GAKIERFYPNAAENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAAT 314
Query: 93 GIGGIVRD--ILCMGARPIALLD---------PIRFGPLEKEKNR---------YLFEYV 132
G GG +RD G+RP A L P P E++ + + E
Sbjct: 315 GAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPDLKQPWEQDYGKPEHISSPLDIMIEGP 374
Query: 133 VKGIADYGNRIGVPTVGG-----ETEFDESLDNYTLVNVVCVGIMKPE-HLVHSYVTKPG 186
+ G A + N G P + G E +FD + Y ++ G+ + H G
Sbjct: 375 IGGAA-FNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEG 433
Query: 187 LKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTG- 245
L+ +G G+ G +S + N D ++VQ +P E+ E G
Sbjct: 434 ALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGG 493
Query: 246 --KVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLF 303
+ ++ D+G GGL+ A E+ GAV VPL E G+ PL++ +ESQER +
Sbjct: 494 KNPIISIHDVGAGGLSNAFPELVNDARRGAVFKLREVPLEEHGLNPLQIWCNESQERYVL 553
Query: 304 AVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIELLTNVPTIEWPM 363
++ +D++ I E+ +AVVG ++ V + D A+ P++L NV + P
Sbjct: 554 SILEKDLDAFRAICERERCPFAVVGTATDDGHLKV--RDDLFANNPVDLPLNVLLGKLP- 610
Query: 364 KEYKLEEDV-------ETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRT------ 410
K + ++ V DI +++A V P + AK ++ D V G T
Sbjct: 611 KTTRTDKTVAPSKKPFHAGDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGLTHRDQMV 670
Query: 411 --VVKPGFDAAV--LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKP 466
P D AV + N G A++ P+ + V E + N+ +V
Sbjct: 671 GKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITNIAAVNIGD 730
Query: 467 LALVD-NLNFASP-----ERPEVYWSFVETVKGLADAAKAFDLAYVSGNVSFYNEVV--- 517
+ + + N+ + E ++Y TV+ ++ A +A DL+ G S + V
Sbjct: 731 IGNIKLSANWMAACGNEGEDEKLY----RTVEAVSKACQALDLSIPVGKDSLSMKTVWQD 786
Query: 518 ----DRPVKPTPVV----AGIGKVKLKDIPRGPRDGDVIAL---IGSTRRELGGSELYRV 566
V P ++ A + V+ P D + L +G + +GGS +V
Sbjct: 787 GEEKKSVVSPLSLIISAFAPVKDVRKTVTPELKNVEDSVLLFVDLGFGKARMGGSAFGQV 846
Query: 567 LGIKGGIAPRVNLEEEKGNALAILNLI-----ENDLVTFVHDVSRGGVAVALAELS 617
G AP + ++ G A ++I EN L+ + HD S GG+ L E++
Sbjct: 847 YNNMSGDAPDL---DDTGRLKAFYSVIQQLVAENKLLAY-HDRSDGGLFAVLVEMA 898
>pir||B83175 phosphoribosylformylglycinamidine synthase PA3763 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9949933|gb|AAG07150.1|AE004795_2 (AE004795)
phosphoribosylformylglycinamidine synthase [Pseudomonas
aeruginosa]
Length = 1298
Score = 124 bits (309), Expect = 3e-27
Identities = 167/708 (23%), Positives = 288/708 (40%), Gaps = 78/708 (11%)
Query: 67 ESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRD--ILCMGARPIALLDPIRFGPLE--- 121
E I++ +E+HNHP+A+ P+ GA+TG GG +RD GA+P A L L+
Sbjct: 283 EPVQILMKVETHNHPTAIAPFPGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLQIPG 342
Query: 122 -----------KEKNRYLFEYVVKGI---ADYGNRIGVPTVGG---------ETEFDESL 158
E+ + +V+G A + N G P + G T E +
Sbjct: 343 FEQPWEVPYGKPERIVTALDIMVEGPLGGAAFNNEFGRPALTGYFRTFEQKIATPHGEEV 402
Query: 159 DNYTLVNVVCVGI--MKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAE 216
Y ++ G+ ++ EH+ ++ G KL+++G G+ G +S ++
Sbjct: 403 RGYHKPIMLAGGMGNIRDEHVQKGEISV-GAKLIVLGGPAMLIGLGGGAASSMATGASSA 461
Query: 217 EEDRSAVQIPDPFTEKLLIEATLEAVYTGK---VKALKDLGGGGLTCAASEMAGKKGLGA 273
+ D ++VQ +P E+ E G+ + + D+G GGL+ A E+ G G
Sbjct: 462 DLDFASVQRDNPEMERRCQEVIDRCWQLGERNPISFIHDVGAGGLSNALPELINDGGRGG 521
Query: 274 VIYADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEE 333
VP EPGM+PLE+ +ESQER + +V+ D E I E+ +AVVGE IE+
Sbjct: 522 RFELRAVPNDEPGMSPLEIWCNESQERYVLSVDAADFETFKAICERERCPFAVVGEAIEQ 581
Query: 334 PRFVVYWK--GDKVADLPIE-LLTNVPTIEWPM-KEYKLEEDVETPDIALSKAFDLVWSS 389
+ V +K D+P+E LL P + + +E +L +D + + L ++ + V
Sbjct: 582 RQLTVADSHFDNKPVDMPLEVLLGKAPRMHRAVTREAELGDDFDAAGLELQESVERVLRH 641
Query: 390 PNIVAKRWVWEQYDHEVQGRTV--------VKPGFDAAVLKINGEY--GLAITSDGNPSY 439
P + +K ++ D + G P D AV + + G A+
Sbjct: 642 PAVASKSFLITIGDRTITGLVARDQMVGPWQVPVADCAVTATSFDVYTGEAMAMGERTPL 701
Query: 440 CYLNPYHGAMGTVAEVVRNLVSVGAKPLALVD-NLNF-ASPERPEVYWSFVETVKGLA-- 495
L+ + E V NL + L+ + + N+ A+ P +TVK +
Sbjct: 702 ALLDAPASGRMAIGETVTNLAAARVGKLSDIKLSANWMAAAGHPGEDARLYDTVKAVGME 761
Query: 496 -------------DAAKAFDLAYVSGNVSFYNEVVDRPVKPTPVVAGIGKVKLKDIPRGP 542
D+ +G V V VA + + +
Sbjct: 762 LCPELGITIPVGKDSMSMKTRWQDNGEDKSVTSPVSLIVTGFAPVADVRQSLTPQLRLDK 821
Query: 543 RDGDVIAL-IGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILNLIEND-LVTF 600
+ D+I + +G + LGGS L +V G G P V+ E+ A++ + D +
Sbjct: 822 GETDLILIDLGRGKNRLGGSILAQVHGKLGRAVPDVDDAEDLKAFFAVIQGLNADGHILA 881
Query: 601 VHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSID----FAFSESHGRYIITLPEDKVE 656
HD S GG+ ++ E++ + GV+ + S + FSE G I E
Sbjct: 882 YHDRSDGGLITSVLEMAFAGHCGVELNLDALADSREELAAVLFSEELGAVIQVREGATPE 941
Query: 657 EAKEIAK------ISIVGR-VGGDNFALEVNGEKVEKDIEELSRIYWN 697
+ + ++++G+ V G L NGE V + + W+
Sbjct: 942 VLAQFSAAGLDDCVAVIGQPVNGYEINLNYNGETVYSAQRRILQRIWS 989
>pir||A82272 phosphoribosylformylglycinamidine synthase VC0869 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9655322|gb|AAF94031.1| (AE004171)
phosphoribosylformylglycinamidine synthase [Vibrio
cholerae]
Length = 1297
Score = 124 bits (308), Expect = 4e-27
Identities = 189/799 (23%), Positives = 318/799 (39%), Gaps = 122/799 (15%)
Query: 12 RLGREPNEVEKAMLEVMWSEHVSYK---------------SSRKWLKLLPTKNEHVILGP 56
+LGR PN++E M SEH +K S K +K + +L
Sbjct: 196 KLGRNPNDIELMMFAQANSEHCRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSA 255
Query: 57 GEDAGVVK-------------------FDESTWIVIGIESHNHPSAVEPYGGAATGIGGI 97
+D V E I++ +E+HNHP+A+ P+ GA+TG GG
Sbjct: 256 YKDNAAVMTGSTVGRFFPDPESRQYTYHHEDAHILMKVETHNHPTAISPWPGASTGSGGE 315
Query: 98 VRD--ILCMGARPIA---------LLDPIRFGPLEKEKNR---------YLFEYVVKGIA 137
+RD +G +P A L P P E + + + E + G A
Sbjct: 316 IRDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPWESDFGKPSRIVNALDIMLEGPLGGAA 375
Query: 138 DYGNRIGVPTVGGETE-FDESLDNYT----------LVNVVCVGIMKPEHLVHSYVTKPG 186
+ N G P + G ++E + ++ ++ +G ++ EH+ + G
Sbjct: 376 -FNNEFGRPNLLGYFRTYEEKVTSHAGEEVRGYHKPIMIAGGMGNIRAEHIQKKEIPV-G 433
Query: 187 LKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGK 246
KL+++G G+ G +S ++AE+ D ++VQ +P E+ E G
Sbjct: 434 AKLIVLGGPAMNIGLGGGAASSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLGD 493
Query: 247 ---VKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLF 303
+ + D+G GG++ A E+ G VP EPGM+PLE+ +ESQER +
Sbjct: 494 KNPIAFIHDVGAGGISNALPELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYVL 553
Query: 304 AVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWKGDKVADLPIE-----LLTNVPT 358
AV ED+ I ++ +AVVGE EE + + A+ PI+ LL P
Sbjct: 554 AVAAEDMPLFDAICQRERAPYAVVGEATEERHLTL--EDSHFANTPIDMPMDILLGKPPK 611
Query: 359 IEWPMKEYKLEED-VETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTV------ 411
+ K+ +E I L++A D V P + K ++ D V G
Sbjct: 612 MHREASTLKVSSPALERSGIELNEAVDRVLRLPAVAEKTFLITIGDRSVTGLVARDQMVG 671
Query: 412 --VKPGFDAAV--LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPL 467
P + AV + +G A++ L+ A V E + N+ + L
Sbjct: 672 PWQVPVANCAVTAASFDSYHGEAMSMGERTPVALLDFGASARLAVGEAITNIAATDIGEL 731
Query: 468 ALVD-NLNFASPE-RPEVYWSFVETVKGLA-DAAKAFDLAYVSGNVSF-----YNEVVDR 519
+ + N+ SP P E VK + + A + G S + E ++
Sbjct: 732 KRIKLSANWMSPAGHPGEDAGLYEAVKAVGEELCPALGITIPVGKDSMSMKTKWQENGEQ 791
Query: 520 PVKPTPV------VAGIGKVKLKDIPRGPRDGDVIALI----GSTRRELGG---SELYRV 566
+P+ A + ++ P+ D +LI G+ + LG +++Y+
Sbjct: 792 KEVTSPLSLIITAFARVEDIRKTVTPQLRTDLGETSLILIDLGNGQNRLGATALAQVYKQ 851
Query: 567 LGIKGGIAPRVNLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKA 626
LG K A N + KG A+ L+ ND + HD GG+ V LAE++ + G+KA
Sbjct: 852 LGDKP--ADVDNAAQLKGFFDAVQTLVRNDKLVAYHDKGDGGLLVTLAEMAFAGHCGIKA 909
Query: 627 KF-TSSFKSIDFAFSESHGRYIITLPEDKVEEAKEI-------AKISIVGRVGGDNFALE 678
T ++ F+E G ++ + D++ A ++G V + L
Sbjct: 910 NIETLGDDALAALFNEELGA-VVQVKNDELNAVLATLAAHGLEACAHVIGEVEASDRLLI 968
Query: 679 VNGEKV--EKDIEELSRIY 695
GE+V E+ EL I+
Sbjct: 969 TCGEEVLIERSRTELRTIW 987
>gb|AAB08888.1| (U68728) phosphoribosylformylglycinamidine synthetase [Salmonella
typhimurium]
Length = 1295
Score = 118 bits (293), Expect = 2e-25
Identities = 178/794 (22%), Positives = 324/794 (40%), Gaps = 113/794 (14%)
Query: 12 RLGREPNEVEKAMLEVMWSEHVSYKS-SRKWL---------------KLLPTKNEHVILG 55
+LGR PN++E M SEH +K + W+ T ++V+
Sbjct: 196 KLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIKNTFETTPDYVLSA 255
Query: 56 PGEDAGVVK------------------FDESTWIVIGIESHNHPSAVEPYGGAATGIGGI 97
++A V++ E I++ +E+HNHP+A+ P+ GAATG GG
Sbjct: 256 YKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMKVETHNHPTAISPWPGAATGSGGE 315
Query: 98 VRD--ILCMGARPIALL-----DPIRFGPLEK--EKNRYLFEYVVKGI----------AD 138
+RD GA+P A L +R E+ E++ E +V + A
Sbjct: 316 IRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAA 375
Query: 139 YGNRIGVPTVGGETE-FDESLDNYT----------LVNVVCVGIMKPEHLVHSYVTKPGL 187
+ N G P + G ++E ++++ ++ +G ++ +H+ + G
Sbjct: 376 FNNEFGRPALTGYFRTYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVV-GA 434
Query: 188 KLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKL---LIEATLEAVYT 244
KL+++G G+ G +S ++ + D ++VQ +P E+ +I+ +
Sbjct: 435 KLIVLGGPAMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGDA 494
Query: 245 GKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFA 304
+ + D+G GGL+ A E+ G G + EPGM+PLE+ +ESQER + A
Sbjct: 495 NPILFIHDVGAGGLSNAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLA 554
Query: 305 VEPEDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWK--GDKVADLPIE-LLTNVPTIEW 361
V + + ++ ++ +AV+G+ EE ++ ++ DLP++ LL P +
Sbjct: 555 VAADQLPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPKMTR 614
Query: 362 PMKEYKLEED-VETPDIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTV--------V 412
++ K + D + DI ++ A V P + K ++ D V G
Sbjct: 615 DVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGDRTVTGMVARDQMVGPWQ 674
Query: 413 KPGFDAAV--LKINGEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSV---GAKPL 467
P D AV ++ YG A++ L+ A V E + N+ + K +
Sbjct: 675 VPVADCAVTTASLDSYYGEAMSIGERAPVALLDFAASARLAVGEALTNIAATQIGDIKRI 734
Query: 468 ALVDNLNFASPERPEVYWSFVETVKGLA-DAAKAFDLAYVSGNVSF-----YNEVVDRPV 521
L N A+ P + VK + + L G S + E ++
Sbjct: 735 KLSANW-MAAAGHPGEDAGLYDAVKAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQRE 793
Query: 522 KPTPVVAGIGK-VKLKDI-----PRGPRDGDVIALI--GSTRRELGG---SELYRVLGIK 570
+P+ I +++D+ P+ + + + LI G LG +++YR LG K
Sbjct: 794 MTSPLSLVISAFARVEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDK 853
Query: 571 GGIAPRVNLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTS 630
A ++ + KG A+ L+ + HD S GG+ V LAE++ + GV+ +
Sbjct: 854 P--ADVRDVAQLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAA 911
Query: 631 -SFKSIDFAFSESHGRYIITLPEDKVEEAKEIAKISIVGRV-------GGDNFALEVNGE 682
+ F+E G I ED+ +A+ + V GD F + N +
Sbjct: 912 LGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAGDRFVITANDQ 971
Query: 683 KVEKDIEELSRIYW 696
V + R++W
Sbjct: 972 TVFSESRTTLRVWW 985
>dbj|BAA20816.1| (AB002359) KIAA0361 [Homo sapiens]
Length = 1371
Score = 116 bits (287), Expect = 1e-24
Identities = 160/643 (24%), Positives = 255/643 (38%), Gaps = 103/643 (16%)
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMG--ARPIALLDPIRFG---------P 119
+V E+HN P+ V P+ GA TG GG +RD+ C G A +A FG P
Sbjct: 337 VVFTAETHNFPTGVCPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGYNLP 396
Query: 120 LEKEKNRYLFEYV---------VKGIADYGNRIGVPTVGGETEFDESL-------DNYTL 163
E +Y + G +DYGN+ G P + G F SL
Sbjct: 397 WEDLSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAG---FARSLGLQLPDGQRREW 453
Query: 164 VNVVC----VGIMKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELS-ENAEEE 218
+ + +G M+ +H + +PG+++V VG R G+ G +S ++ +N +
Sbjct: 454 IKPIMFSGGIGSMEADH-ISKEAPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSDL 512
Query: 219 DRSAVQIPDPFTEKLL---IEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVI 275
D AVQ DP E+ + I A +EA + +L D G GG E++ G A+I
Sbjct: 513 DFGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAG--AII 570
Query: 276 YADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPR 335
Y R L +P + LE+ +E QE + + + L + + VG I + R
Sbjct: 571 YTSRFQLGDPTLNALEIWGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRR 630
Query: 336 FVVY----------WKGD---KVADLPIELLTNVPTIEWPMKEYKLEED-------VETP 375
V+ +GD P++L + P KE+ L+ P
Sbjct: 631 IVLVDDRECPVRRNGQGDAPPTPPPTPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPP 690
Query: 376 DIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVK--------PGFDAAVLKINGE- 426
+++ +A + V P + +KR++ + D V G + P D AV+ ++ E
Sbjct: 691 GLSVHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEE 750
Query: 427 -YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPERPEVYW 485
G A P L+P A VAE + NLV ALV +L + W
Sbjct: 751 LIGAATALGEQPVKSLLDPKVAARLAVAEALTNLV------FALVTDLR---DVKCSGNW 801
Query: 486 SFVETVKG----LADAAK-------AFDLAYVSGNVSFY------NEVVDRP----VKPT 524
+ + G LADA + A +A G S E V P +
Sbjct: 802 MWAAKLPGEGAALADACEAMVAVMAALGVAVDGGKDSLSMAARVGTETVRAPGSLVISAY 861
Query: 525 PVVAGIGKVKLKDIPRGPRDGDVI-ALIGSTRRELGGSELYRVLGIKGGIAPRVNLEEEK 583
V I D+ G ++ + + LGG+ L + G P ++L E
Sbjct: 862 AVCPDITATVTPDLKHPEGRGHLLYVALSPGQHRLGGTALAQCFSQLGEHPPDLDLPENL 921
Query: 584 GNALAIL-NLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVK 625
A +I L+++ L+ HDVS GG+ L E++ N G++
Sbjct: 922 VRAFSITQGLLKDRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQ 964
>pir||H64090 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) - Haemophilus
influenzae (strain Rd KW20) >gi|1573760|gb|AAC22411.1|
(U32759) phosphoribosylformylglycinamidine synthase
(purL) [Haemophilus influenzae Rd]
Length = 1320
Score = 115 bits (284), Expect = 2e-24
Identities = 170/721 (23%), Positives = 288/721 (39%), Gaps = 87/721 (12%)
Query: 56 PGEDAGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRD--ILCMGARPIALLD 113
P D E I++ +E+HNHP+A+ P+ GAATG GG +RD GA+P A L
Sbjct: 298 PDPDGQYRVHQEDVHILMKVETHNHPTAISPFPGAATGSGGEIRDEGATGRGAKPKAGLT 357
Query: 114 PIRFG-------------PLEKEKNRYLFEYVVK-----GIADYGNRIGVPTVGGETE-F 154
PL K NR + G A + N G P + G +
Sbjct: 358 GFSVSNLVIPNFEQPWENPLSKP-NRIASALDIMIDAPLGSAAFNNEFGRPALLGYFRTY 416
Query: 155 DESLDNYTLVNVVCVGIMKPEHL-----------VHSYVTKPGLKLVLVGNRTGRDGIHG 203
+E ++++ V G KP L V G KL+++G G+ G
Sbjct: 417 EEKVNSFAGKEVR--GYHKPIMLAGGIGNIRGEQVQKGEIPIGAKLIVLGGAAMNIGLGG 474
Query: 204 VTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGK---VKALKDLGGGGLTC 260
+S + ++ E+ D ++VQ +P E+ E G+ + + D+G GGL+
Sbjct: 475 GAASSMDSGKSKEDLDFASVQRENPEMERRCQEVIDRCWQLGEENPILFIHDVGAGGLSN 534
Query: 261 AASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKY 320
A E+ G + E GM+PLE+ +ESQER + AV PE++E + E+
Sbjct: 535 AMPELVHDGKRGGKFDLRSILCDEKGMSPLEIWCNESQERYVLAVAPENLELFTALCERE 594
Query: 321 ELEWAVVGEIIEEPRFVVYWK--GDKVADLPIE-LLTNVPTIEWPMKEYKLE-EDVETPD 376
+AV+GE + +++ + DLP+ LL P + + +E + ++
Sbjct: 595 RAPFAVIGEATQAEHLILHDSHFDNNPIDLPMNVLLGKTPKMTREVLSKTVENQSLKIES 654
Query: 377 IALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVK--------PGFDAAV--LKINGE 426
I L +AF V P + K ++ D V G P D AV ++
Sbjct: 655 IQLKEAFHRVLRLPVVAEKTFLITIGDRSVTGMVARDQMVGPWQIPVSDVAVTTASLDSY 714
Query: 427 YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSV---GAKPLALVDNLNFASPERPEV 483
+G A+ L+ A VAE + N+ K + L N A+ E
Sbjct: 715 HGEAMAIGERSPVALLDFSASARLAVAEAITNIAGTLIGEMKRIKLSANWMSAAGHTGED 774
Query: 484 YWSFVETVKGLAD---AAKAFDLAYVSGNVSFYNEVVDR-----PVKPTPVV----AGIG 531
E VK + + A + ++S +D P +V A +
Sbjct: 775 A-GLYEAVKAVGEELCPALGLTIPVGKDSMSMKTTWIDNGEQKSVTAPLSLVISAFARVE 833
Query: 532 KVKLKDIPRGPRDGDVIAL----IGSTRRELGG---SELYRVLGIKGGIAPRVNLEEEKG 584
V+ P+ D +L +G LG +++Y+ LG K +V ++
Sbjct: 834 DVRKTLTPQLRTDKGFSSLLLIDLGEGHNRLGATALAQVYKQLGDKPADVVKVQRLKDFY 893
Query: 585 NALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTS-SFKSIDFAFSESH 643
NA+ L+ D + HD S GG+ LAE++ + GV+ ++ + F+E
Sbjct: 894 NAMQ--TLVAEDKLLAYHDRSDGGLITTLAEMAFAGHCGVEVDISALGDNDLAVLFNEEL 951
Query: 644 GRYIITLPEDKVEEAKEIAK----ISIVGRVG----GDNFALEVNGEKVEKDIEELSRIY 695
G +I + + ++E +E+ K + I+ ++G D F + K+ + R
Sbjct: 952 GA-VIQVADSQLESVREVLKAHNLLGIIHQLGTVTADDRFEISRGSHKLFSEKRSELRSI 1010
Query: 696 W 696
W
Sbjct: 1011 W 1011
>sp|P43847|PURL_HAEIN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (FGAM SYNTHASE)
(FORMYLGLYCINAMIDE RIBOTIDE AMIDOTRANSFERASE) (FGARAT)
Length = 1297
Score = 115 bits (284), Expect = 2e-24
Identities = 170/721 (23%), Positives = 288/721 (39%), Gaps = 87/721 (12%)
Query: 56 PGEDAGVVKFDESTWIVIGIESHNHPSAVEPYGGAATGIGGIVRD--ILCMGARPIALLD 113
P D E I++ +E+HNHP+A+ P+ GAATG GG +RD GA+P A L
Sbjct: 275 PDPDGQYRVHQEDVHILMKVETHNHPTAISPFPGAATGSGGEIRDEGATGRGAKPKAGLT 334
Query: 114 PIRFG-------------PLEKEKNRYLFEYVVK-----GIADYGNRIGVPTVGGETE-F 154
PL K NR + G A + N G P + G +
Sbjct: 335 GFSVSNLVIPNFEQPWENPLSKP-NRIASALDIMIDAPLGSAAFNNEFGRPALLGYFRTY 393
Query: 155 DESLDNYTLVNVVCVGIMKPEHL-----------VHSYVTKPGLKLVLVGNRTGRDGIHG 203
+E ++++ V G KP L V G KL+++G G+ G
Sbjct: 394 EEKVNSFAGKEVR--GYHKPIMLAGGIGNIRGEQVQKGEIPIGAKLIVLGGAAMNIGLGG 451
Query: 204 VTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGK---VKALKDLGGGGLTC 260
+S + ++ E+ D ++VQ +P E+ E G+ + + D+G GGL+
Sbjct: 452 GAASSMDSGKSKEDLDFASVQRENPEMERRCQEVIDRCWQLGEENPILFIHDVGAGGLSN 511
Query: 261 AASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKY 320
A E+ G + E GM+PLE+ +ESQER + AV PE++E + E+
Sbjct: 512 AMPELVHDGKRGGKFDLRSILCDEKGMSPLEIWCNESQERYVLAVAPENLELFTALCERE 571
Query: 321 ELEWAVVGEIIEEPRFVVYWK--GDKVADLPIE-LLTNVPTIEWPMKEYKLE-EDVETPD 376
+AV+GE + +++ + DLP+ LL P + + +E + ++
Sbjct: 572 RAPFAVIGEATQAEHLILHDSHFDNNPIDLPMNVLLGKTPKMTREVLSKTVENQSLKIES 631
Query: 377 IALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVK--------PGFDAAV--LKINGE 426
I L +AF V P + K ++ D V G P D AV ++
Sbjct: 632 IQLKEAFHRVLRLPVVAEKTFLITIGDRSVTGMVARDQMVGPWQIPVSDVAVTTASLDSY 691
Query: 427 YGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSV---GAKPLALVDNLNFASPERPEV 483
+G A+ L+ A VAE + N+ K + L N A+ E
Sbjct: 692 HGEAMAIGERSPVALLDFSASARLAVAEAITNIAGTLIGEMKRIKLSANWMSAAGHTGED 751
Query: 484 YWSFVETVKGLAD---AAKAFDLAYVSGNVSFYNEVVDR-----PVKPTPVV----AGIG 531
E VK + + A + ++S +D P +V A +
Sbjct: 752 A-GLYEAVKAVGEELCPALGLTIPVGKDSMSMKTTWIDNGEQKSVTAPLSLVISAFARVE 810
Query: 532 KVKLKDIPRGPRDGDVIAL----IGSTRRELGG---SELYRVLGIKGGIAPRVNLEEEKG 584
V+ P+ D +L +G LG +++Y+ LG K +V ++
Sbjct: 811 DVRKTLTPQLRTDKGFSSLLLIDLGEGHNRLGATALAQVYKQLGDKPADVVKVQRLKDFY 870
Query: 585 NALAILNLIENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTS-SFKSIDFAFSESH 643
NA+ L+ D + HD S GG+ LAE++ + GV+ ++ + F+E
Sbjct: 871 NAMQ--TLVAEDKLLAYHDRSDGGLITTLAEMAFAGHCGVEVDISALGDNDLAVLFNEEL 928
Query: 644 GRYIITLPEDKVEEAKEIAK----ISIVGRVG----GDNFALEVNGEKVEKDIEELSRIY 695
G +I + + ++E +E+ K + I+ ++G D F + K+ + R
Sbjct: 929 GA-VIQVADSQLESVREVLKAHNLLGIIHQLGTVTADDRFEISRGSHKLFSEKRSELRSI 987
Query: 696 W 696
W
Sbjct: 988 W 988
>pir||T11661 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) - fission
yeast (Schizosaccharomyces pombe)
>gi|2330857|emb|CAB11094.1| (Z98533)
phosphoribosylformylglycinamidine synthase
[Schizosaccharomyces pombe]
Length = 1323
Score = 114 bits (282), Expect = 4e-24
Identities = 174/760 (22%), Positives = 303/760 (38%), Gaps = 132/760 (17%)
Query: 15 REPNEVEKAMLEVMWSEHVSYK---------------SSRKWLKLLPTKN-EHVILGPGE 58
REP +VE M + SEH +K S K ++ KN ++ I +
Sbjct: 206 REPTDVELFMFGQVNSEHCRHKIFNADWTIDGEKKDYSLFKMIRNTHLKNPQYTISAYSD 265
Query: 59 DAGVVKFDEST--------WIV-------IG-IESHNHPSAVEPYGGAATGIGGIVRDIL 102
+A V + + T W + +G +E+HNHP+AV P+ GAATG GG +RD
Sbjct: 266 NAAVFEGNSGTLFAPVNGIWSMKDEPVEFLGKVETHNHPTAVSPFPGAATGSGGEIRDEG 325
Query: 103 CMGARPIA-----------LLDPIRFGPLEKEKNR---------YLFEYVVKGIADYGNR 142
+G ++ L P P E + + + E + G + + N
Sbjct: 326 AVGQGSLSKAGLAGYSVSDLNIPGYKQPWELDVGKPYHIATSLDIMLEAPI-GSSAFNNE 384
Query: 143 IGVPTVGGETEF--------DESLD----NYTLVNVVCVGIMKPEHLVHSYVTKPGLKLV 190
G P + G D +L+ + ++ +G ++ +H + PG ++
Sbjct: 385 FGRPCINGYFRTFCMEVPRGDGTLEIRGYHKPIMAAGGIGRIRKQHAFKKSIA-PGSPII 443
Query: 191 LVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYT---GKV 247
++G G+ G +S E +EE D ++VQ +P ++ + ++A T +
Sbjct: 444 VLGGPALLVGLGGGAASSMNAGEGSEELDFASVQRGNPEMQRRA-QMVIDACTTMDENII 502
Query: 248 KALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREPGMTPLEVMISESQERMLFAVEP 307
+++ D+G GG++ A E+ GLGA +P EP M+P+++ ESQER + +V+
Sbjct: 503 QSIHDVGAGGVSNALPELVHDAGLGARFELRDIPCIEPSMSPMQIWCCESQERYVLSVKS 562
Query: 308 EDVEELAKIFEKYELEWAVVGEIIEEPRFVVYWK--GDKVADLPIELLTNVPTIEWPMKE 365
ED++ I E+ + VVG E R ++ + DLP+E+L P
Sbjct: 563 EDLDTFKSICERERCPYGVVGYSTVEQRLILTDRLYNTTPIDLPMEVLFGKPP------- 615
Query: 366 YKLEEDVETPDIALSK------------------AFDLVWSSPNIVAKRWVWEQYDHEVQ 407
K+ ET I LSK A + V P + +K ++ D V
Sbjct: 616 -KMSRVAETQTIPLSKFDSSLKSYLAPSSDPILDAVERVLRMPAVASKSFLITIGDRSVT 674
Query: 408 GRTV--------VKPGFDAAVLKINGEYGL----AITSDGNPSYCYLNPYHGAMGTVAEV 455
G P D V + G+ A+ P ++ A VAE
Sbjct: 675 GLIARDQMVGPWQVPVADVGVTVTSYGKGINTGEALAMGEKPISALVSAAASARMAVAEC 734
Query: 456 VRNLVSVGAKPLALVD-NLNF-ASPERPEVYWSFVETVKGLA-DAAKAFDLAYVSGNVSF 512
+ NLV+ L + + N+ A+P P E V+ + + + ++ G S
Sbjct: 735 IMNLVAASIPALDRIRLSANWMAAPSHPGEGAKLYEAVQAIGLELCPSLGISIPVGKDSM 794
Query: 513 -----YNE------------VVDRPVKPTPVVAGIGKVKLKDIPRGPRDGDVIALIGSTR 555
+NE ++ P + I +L+ + + + + +
Sbjct: 795 SMSMKWNEDGREKSVTAPLSLIITGFSPVDDLYSIWTPQLRKVEDIGSTSLIFIDLANGK 854
Query: 556 RELGGSELYRVLGIKGGIAPRV-NLEEEKGNALAILNLIENDLVTFVHDVSRGGVAVALA 614
+ LGGS L + G P + NL+ K I L + + + HD S GG+ V L+
Sbjct: 855 QRLGGSILAQSYKQLGDEVPDLDNLDTFKNFINVITQLHKTNYIQAYHDKSDGGLFVTLS 914
Query: 615 ELSAWFNVGVKAKFTS-SFKSIDFAFSESHGRYIITLPED 653
E++ +VG++ + S S +I F+E G I D
Sbjct: 915 EMAFAGHVGIECELDSLSSDNIAALFNEELGAVIQVCDRD 954
>gi|6321498 5'-phosphoribosylformyl glycinamidine synthetase; Ade6p
[Saccharomyces cerevisiae]
>gi|1709924|sp|P38972|PUR4_YEAST
PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (FGAM
SYNTHASE) (FORMYLGLYCINAMIDE RIBOTIDE AMIDOTRANSFERASE)
(FGARAT) >gi|2118366|pir||S64356
phosphoribosylformylglycinamidine synthase (EC 6.3.5.3)
- yeast (Saccharomyces cerevisiae)
>gi|1323079|emb|CAA97063.1| (Z72846) ORF YGR061c
[Saccharomyces cerevisiae]
Length = 1358
Score = 112 bits (277), Expect = 2e-23
Identities = 151/621 (24%), Positives = 261/621 (41%), Gaps = 77/621 (12%)
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRD--ILCMGARPIALLDPIRFGPLEKEKNRYL 128
++I +E+HNHP+AV P+ GAATG GG +RD G++ L L N
Sbjct: 327 LLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSKTKCGLSGFSVSDLLIPGNEQP 386
Query: 129 FEYVVK-----------------GIADYGNRIGVPTVGG----------ETEFDESLDNY 161
+E + G A + N G P + G + E + +
Sbjct: 387 WELNIGKPYHIASALDIMIEAPLGSAAFNNEFGRPCINGYFRTLTTKVLNHQGKEEIRGF 446
Query: 162 TLVNVVC--VGIMKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEED 219
++ G ++P+ + + PG L+++G ++ G+ G +S E + + D
Sbjct: 447 HKPIMIAGGFGTVRPQFALKNTPITPGSCLIVLGGQSMLIGLGGGAASSVASGEGSADLD 506
Query: 220 RSAVQIPDPFTEKL---LIEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIY 276
++VQ +P E+ +I+A + ++++ D+G GGL+ A E+ LGA
Sbjct: 507 FASVQRGNPEMERRCQQVIDACVALGNNNPIQSIHDVGAGGLSNALPELVHDNDLGAKFD 566
Query: 277 ADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRF 336
+V EPGM+P+E+ +ESQER + V P+D+ +I ++ +AVVG E +
Sbjct: 567 IRKVLSLEPGMSPMEIWCNESQERYVLGVSPQDLSIFEEICKRERAPFAVVGHATAEQKL 626
Query: 337 VVYWKGDKVA--DLPIELLTNVPTIEWPMKEYKLEEDVETPDIALSK------AFDLVWS 388
+V K DL + +L P M + E + P+ LS+ A V +
Sbjct: 627 IVEDPLLKTTPIDLEMPILFGKPP---KMSRETITEALNLPEANLSEIPSLQDAIQRVLN 683
Query: 389 SPNIVAKRWVWEQYDHEVQG-----RTVVKPGFDAAVLKING-EYGLAITSDG------- 435
P++ +K ++ D V G + V A + + G G I S G
Sbjct: 684 LPSVGSKSFLITIGDRSVTGLIDRDQFVGPWQVPVADVGVTGTSLGETIISTGEAMAMGE 743
Query: 436 NPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVD-NLNFASPERPEVYWS-FVETVKG 493
P ++ A +VAE + N+ + K L + + N+ SP + S E V+
Sbjct: 744 KPVNALISASASAKLSVAESLLNIFAADVKSLNHIKLSANWMSPASHQGEGSKLYEAVQA 803
Query: 494 LA-DAAKAFDLAY------VSGNVSFYNEVVDRP----VKPTPVVAGIGKVKLKDIPRGP 542
L D A +A +S + + ++ V P + V K + R
Sbjct: 804 LGLDLCPALGVAIPVGKDSMSMKMKWDDKEVTAPLSLNITAFAPVFNTSKTWTPLLNRNT 863
Query: 543 RDGDVIALIGSTRRE---LGGSELYRVLGIKGGIAPRV-NLEEEKG--NALAILNLIEND 596
D ++ + S ++E LG S L +V G +P V + KG +L L+ + D
Sbjct: 864 DDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPTVYDNAILKGFLESLIQLHQQKED 923
Query: 597 LVTFVHDVSRGGVAVALAELS 617
+V HD S GG+ + L E++
Sbjct: 924 IVLAYHDRSDGGLLITLLEMA 944
>gb|AAA50357.1| (U14566) formylglycinamide ribonucleotide synthetase [Saccharomyces
cerevisiae]
Length = 1360
Score = 109 bits (271), Expect = 8e-23
Identities = 150/621 (24%), Positives = 260/621 (41%), Gaps = 77/621 (12%)
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRD--ILCMGARPIALLDPIRFGPLEKEKNRYL 128
++I +E+HNHP+AV P+ GAATG GG +RD G++ L L N
Sbjct: 327 LLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSKTKCGLSGFSVSDLLIPGNEQP 386
Query: 129 FEYVVK-----------------GIADYGNRIGVPTVGG----------ETEFDESLDNY 161
+E + G A + N G P + G + E + +
Sbjct: 387 WELNIGKPYHIASALDIMIEAPLGSAAFNNEFGRPCINGYFRTLTTKVLNHQGKEEIRGF 446
Query: 162 TLVNVVC--VGIMKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEED 219
++ G ++P+ + + PG L+++G ++ G+ G +S E + + D
Sbjct: 447 HKPIMIAGGFGTVRPQFALKNTPITPGSCLIVLGGQSMLIGLGGGPASSVASREGSADLD 506
Query: 220 RSAVQIPDPFTEKL---LIEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIY 276
++VQ +P E+ +I+A + ++++ D+G GGL+ E+ LGA
Sbjct: 507 FASVQRGNPEMERRCQQVIDACVALGNNNPIQSIHDVGAGGLSNTLPELVHDNDLGAKFD 566
Query: 277 ADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRF 336
+V EPGM+P+E+ +ESQER + V P+D+ +I ++ +AVVG E +
Sbjct: 567 IRKVLSLEPGMSPMEIWCNESQERYVLGVSPQDLSIFKEICKRERAPFAVVGHATAEQKL 626
Query: 337 VVYWKGDKVA--DLPIELLTNVPTIEWPMKEYKLEEDVETPDIALSK------AFDLVWS 388
+V K DL + +L P M + E + P+ LS+ A V +
Sbjct: 627 IVEDPLLKTTPIDLEMPILFGKPP---KMSRETITEALNLPEANLSEIPSLQDAIQRVLN 683
Query: 389 SPNIVAKRWVWEQYDHEVQG-----RTVVKPGFDAAVLKING-EYGLAITSDG------- 435
P++ +K ++ D V G + V A + + G G I S G
Sbjct: 684 LPSVGSKSFLITIGDRSVTGLIDRDQFVGPWQVPVADVGVTGTSLGETIISTGEAMAMGE 743
Query: 436 NPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVD-NLNFASPERPEVYWS-FVETVKG 493
P ++ A +VAE + N+ + K L + + N+ SP + S E V+
Sbjct: 744 KPVNALISASASAKLSVAESLLNIFAADVKSLNHIKLSANWMSPASHQGEGSKLYEAVQA 803
Query: 494 LA-DAAKAFDLAY------VSGNVSFYNEVVDRP----VKPTPVVAGIGKVKLKDIPRGP 542
L D A +A +S + + ++ V P + V K + R
Sbjct: 804 LGLDLCPALGVAIPVGKDSMSMKMKWDDKEVTAPLSLNITAFAPVFNTSKTWTPLLNRNT 863
Query: 543 RDGDVIALIGSTRRE---LGGSELYRVLGIKGGIAPRV-NLEEEKG--NALAILNLIEND 596
D ++ + S ++E LG S L +V G +P V + KG +L L+ + D
Sbjct: 864 DDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPTVYDNAILKGFLESLIQLHQQKED 923
Query: 597 LVTFVHDVSRGGVAVALAELS 617
+V HD S GG+ + L E++
Sbjct: 924 IVLAYHDRSDGGLLITLLEMA 944
>pir||T20718 hypothetical protein F10F2.2 - Caenorhabditis elegans
>gi|3875706|emb|CAA84656.1| (Z35598)
Phosphoribosylformylglycinamidine synthase, contains
similarity to Pfam domain: PF00586 (AIR synthase related
protein), Score=138.7, E-value=3.5e-38, N=1~cDNA EST
yk18g10.5 comes from this gene~cDNA EST yk18g10.3 comes
from this gene~cDNA EST >
Length = 1343
Score = 108 bits (267), Expect = 2e-22
Identities = 178/735 (24%), Positives = 295/735 (39%), Gaps = 109/735 (14%)
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDILC--MGARPIALLDPIRFG-------PLE 121
++ E+HN P+AV P+ GA TG GG +RDI GA IA FG PL
Sbjct: 296 LIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGRGAYEIAGTVGYSFGNLNLPGLPLP 355
Query: 122 KEKNRYLFEY-------------VVKGIADYGNRIGVPTVGG-ETEFDESLDN-----YT 162
E FEY G +DYGN+ G P + G F + L+N Y
Sbjct: 356 WEDE--TFEYPTSISEPAKIAIEASNGASDYGNKFGEPVISGFARSFGQRLENGERCEYL 413
Query: 163 LVNVVCVGI-MKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEE-DR 220
+ GI + V P K+V +G R G+ G +S + N E + D
Sbjct: 414 KPIMFSGGIGAIDKDEVRKEPCAPHQKVVKIGGPVYRIGVGGGAASSVSVQGNRENQLDF 473
Query: 221 SAVQIPD-PFTEKL--LIEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYA 277
+AVQ D KL ++ A E + + A+ D G GG E+ +G G + +
Sbjct: 474 AAVQRGDAEMGGKLHRVVRACAERIGGNPLMAIHDQGAGGNGNVIKELV--EGCGVTVKS 531
Query: 278 DRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFV 337
D L + ++ E+ +E QE V+ ++ L I ++ + +VVGE+ +E R
Sbjct: 532 DTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVK 591
Query: 338 VYWKGDKVA-DLPIELLTNVPTIEWPMKEY-KLEEDVETPD-IALSKAFDLVWSSPNIVA 394
+ K ++A DL L + +K ++ + +E P+ + + KA V P++ +
Sbjct: 592 LLGKSGEIAVDLDTRQLGEREKKVFKLKSAPRVLKKLELPENLTVRKALKRVLMLPSVAS 651
Query: 395 KRWVWEQYDHEVQGRTVVK--------PGFDAAVLKIN--GEYGLAITSDGNPSYCYLNP 444
KR++ + D V G + P D AV+ ++ G A++ P ++
Sbjct: 652 KRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDTVGGAVSLGEQPIKMLIDA 711
Query: 445 YHGAMGTVAEVVRNLVSVGAKPLALVDNLNFASPERPEV------------YWS------ 486
GA +AE + NL+ L + + F S + + W+
Sbjct: 712 EKGARMCIAETIMNLIWAPITDLKVHFLIYFYSKFQKLLLSLKDVKMSGNWMWAAKCDGE 771
Query: 487 ---FVETVKGLADAAKAFDLAYVSGN------VSFYNEVVDRP----VKPTPVVAGIGKV 533
V+ V L + A G V+ + EVV P + + KV
Sbjct: 772 GARLVDAVGALCRGLREIGCAIDGGKDSLSMAVTAHGEVVKSPGTLVLSAYAPCTNVTKV 831
Query: 534 KLKDIPRGPRDGDVIALIGST--RRELGGSELYRVLGIKGGIAPRVNLEEEKGNALAILN 591
+ P + IGS+ + LGGS L +V G P + E +I+
Sbjct: 832 VNPSLKAVPGSKILWIKIGSSEEKMRLGGSALAQVYSQIGDDCPDIENFSEISKVFSIVQ 891
Query: 592 LIEN----------DLVTFVHDVSRGGVAVALAELSAWFNVGVKAKF---TSSFKSIDFA 638
+ N ++ HD+S GG+ A+ E++ NV + + K ID
Sbjct: 892 QLLNREELAGPLRKPIILAGHDISDGGLLTAILEMAFAGNVSIDIDIKPPNQNIKPIDIL 951
Query: 639 FSESHGRYI-ITLPEDKVE-------EAKEIAKISIVGRVGGD-NFALEVNGE-KVEKDI 688
F+E G + ++ PE+ + + +EI K S V G D + + VNG ++ + +
Sbjct: 952 FAEECGILLEVSNPENVLHIFSEAGIKCQEIGKASAV--FGPDAHVKIHVNGHLEINEKL 1009
Query: 689 EELSRIYWNYMYDLL 703
+L R W + D L
Sbjct: 1010 VDL-REEWELVGDRL 1023
>gb|AAA75111.2| (U33322) FGAM synthetase [Synechococcus PCC7942]
Length = 113
Score = 108 bits (266), Expect = 3e-22
Identities = 50/93 (53%), Positives = 62/93 (65%)
Query: 3 PREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGV 62
P E I ERLGR PN+ E M VMWSEH YK+SR L PT+ +++GPGE+AGV
Sbjct: 21 PEEYDAIVERLGRHPNKAELGMFGVMWSEHCCYKNSRPLLSQFPTEGLRILVGPGENAGV 80
Query: 63 VKFDESTWIVIGIESHNHPSAVEPYGGAATGIG 95
V + + +ESHNHPSAVEP+ GAATG+G
Sbjct: 81 VDLGDGLHLAFKVESHNHPSAVEPFQGAATGVG 113
>gb|AAF52329.1| (AE003612) ade2 gene product [Drosophila melanogaster]
Length = 1354
Score = 108 bits (266), Expect = 3e-22
Identities = 158/631 (25%), Positives = 251/631 (39%), Gaps = 91/631 (14%)
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDI---------------LCMGA--------- 106
++ E+HN P+AV P+ GA TG GG +RD+ C+GA
Sbjct: 309 LIFTAETHNMPTAVAPFSGATTGTGGRLRDVQGVGRGGVPIAGTAGYCVGALHIPGYKQP 368
Query: 107 -RPIALLDPIRFGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGG-------ETEFDES- 157
P+ P F P + L E G +DYGN+ G P + G + D S
Sbjct: 369 YEPLDFKYPATFAP----PLQVLIE-ASNGASDYGNKFGEPVISGFALSYGLNSAADASQ 423
Query: 158 LDNYTLVNVVCVGI-MKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAE 216
D Y + G+ P + G L +G R G+ G +S E+ + +
Sbjct: 424 RDEYVKPIMFSGGLGTMPATMREKLPPARGQLLAKIGGPVYRIGVGGGAASSVEIQGSGD 483
Query: 217 EE-DRSAVQIPDPFTEKLL---IEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLG 272
E D +AVQ D E L + A L+ + A+ D G GG E+ G
Sbjct: 484 AELDFNAVQRGDAEMENKLNRVVRACLDLGEQNPILAIHDQGAGGNGNVLKELVEPGFAG 543
Query: 273 AVIYADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIE 332
AVI++ L +P +T LE+ +E QE + E L KI + + VG +
Sbjct: 544 AVIFSKEFQLGDPTITALELWGAEYQENNAILCNADQRELLEKICRRERCPISFVGVVTG 603
Query: 333 EPRFVVYWK------------GDKVADLPIELLTNVPTIEWPMKEYKLEEDVETP----- 375
+ R + K ++ P +L + P + Y L+ + +TP
Sbjct: 604 DGRVTLLEKPAPKDLEQALNASNRSEVSPFDLELKYVLGDMPKRTYDLKRE-QTPLKELS 662
Query: 376 ---DIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVK--------PGFDAAVLKIN 424
+ L +A + V S + +KR++ + D V G + P D A+ ++
Sbjct: 663 LPKGLLLDEALERVLSLVAVGSKRFLTNKVDRCVGGLIAQQQCVGPLQAPLADYALTTVS 722
Query: 425 --GEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALV---DNLNFASPE 479
G+A + P L+P A VAE + NLV V LA V N +A+ +
Sbjct: 723 HFSHSGIATSIGTQPLKGLLDPAAMARMCVAEALSNLVFVKISELADVKCSGNWMWAA-K 781
Query: 480 RPEVYWSFVETVKGLADAAKAFDLAYVSG--NVSFYNEVVDRPVK-PTPVV----AGIGK 532
P + K L + +A G ++S +V +K P +V A
Sbjct: 782 LPGEGARMFDACKELCQILEELHIAIDGGKDSLSMAAKVGGETIKSPGTLVISTYAPCPD 841
Query: 533 VKLKDIP--RGPRDGDVIALIG---STRRELGGSELYRVLGIKGGIAPRVNLEEEKGNAL 587
V+LK P +GP G +L+ LGGS L + +G P + + G A
Sbjct: 842 VRLKVTPDLKGPGAGSKTSLLWINLENSARLGGSALAQAYAQQGKDTPNLTRSDVLGKAF 901
Query: 588 AIL-NLIENDLVTFVHDVSRGGVAVALAELS 617
A+ +L+ + L+ HDVS GG+ V + E++
Sbjct: 902 AVTQSLLGDGLIQAGHDVSDGGLLVCVLEMA 932
>sp|P35421|PUR4_DROME PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (FGAM SYNTHASE)
(FORMYLGLYCINAMIDE RIBOTIDE AMIDOTRANSFERASE) (FGARAT)
(ADENOSINE-2) (FGAMS) (FORMYLGLYCINAMIDE RIBOTIDE
SYNTHETASE) >gi|7438074|pir||T13363
phosphoribosylformylglycinamidine synthase (EC 6.3.5.3)
- fruit fly (Drosophila melanogaster)
>gi|414423|gb|AAC46468.1| (U00683) formylglycineamide
ribotide amidotransferase [Drosophila melanogaster]
Length = 1354
Score = 106 bits (262), Expect = 9e-22
Identities = 158/631 (25%), Positives = 250/631 (39%), Gaps = 91/631 (14%)
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDI---------------LCMGA--------- 106
++ E+HN P+AV P+ GA TG GG +RD+ C+GA
Sbjct: 309 LIFTAETHNMPTAVAPFSGATTGTGGRLRDVQGVGRGGVPIAGTAGYCVGALHIPGYKQP 368
Query: 107 -RPIALLDPIRFGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGG-------ETEFDES- 157
P+ P F P + L E G +DYGN+ G P + G + D S
Sbjct: 369 YEPLDFKYPATFAP----PLQVLIE-ASNGASDYGNKFGEPVISGFALSYGLNSAADASQ 423
Query: 158 LDNYTLVNVVCVGI-MKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAE 216
D Y + G+ P + G L +G R G+ G +S E+ + +
Sbjct: 424 RDEYVKPIMFSGGLGTMPATMREKLPPARGQLLAKIGGPVYRIGVGGGAASSVEIQGSGD 483
Query: 217 EE-DRSAVQIPDPFTEKLL---IEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLG 272
E D +AVQ D E L + A L+ + A+ D G GG E+ G
Sbjct: 484 AELDFNAVQRGDAEMENKLNRVVRACLDLGEQNPILAIHDQGAGGNGNVLKELVEPGFAG 543
Query: 273 AVIYADRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIE 332
AVI++ L +P T LE+ +E QE + E L KI + + VG +
Sbjct: 544 AVIFSKEFQLGDPTYTALELWGAEYQENNAILCNADQRELLEKICRRERCPISFVGVVTG 603
Query: 333 EPRFVVYWKG------------DKVADLPIELLTNVPTIEWPMKEYKLEEDVETP----- 375
+ R + K ++ P +L + P + Y L+ + +TP
Sbjct: 604 DGRVTLLEKPAPKDLEQALNAFNRSEVSPFDLELKYVLGDMPKRTYDLKRE-QTPLKELS 662
Query: 376 ---DIALSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVK--------PGFDAAVLKIN 424
+ L +A + V S + +KR++ + D V G + P D A+ ++
Sbjct: 663 LPKGLLLDEALERVLSLVAVGSKRFLTNKVDRCVGGLIAQQQCVGPLQAPLADYALTTVS 722
Query: 425 --GEYGLAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALV---DNLNFASPE 479
G+A + P L+P A VAE + NLV V LA V N +A+ +
Sbjct: 723 HFSHSGIATSIGTQPLKGLLDPAAMARMCVAEALSNLVFVKISELADVKCSGNWMWAA-K 781
Query: 480 RPEVYWSFVETVKGLADAAKAFDLAYVSG--NVSFYNEVVDRPVK-PTPVV----AGIGK 532
P + K L + +A G ++S +V +K P +V A
Sbjct: 782 LPGEGARMFDACKELCQILEELHIAIDGGKDSLSMAAKVGGETIKSPGTLVISTYAPCPD 841
Query: 533 VKLKDIP--RGPRDGDVIALIG---STRRELGGSELYRVLGIKGGIAPRVNLEEEKGNAL 587
V+LK P +GP G +L+ LGGS L + +G P + + G A
Sbjct: 842 VRLKVTPDLKGPGAGSKTSLLWINLENSARLGGSALAQAYAQQGKDTPNLTRSDVLGKAF 901
Query: 588 AIL-NLIENDLVTFVHDVSRGGVAVALAELS 617
A+ +L+ + L+ HDVS GG+ V + E++
Sbjct: 902 AVTQSLLGDGLIQAGHDVSDGGLLVCVLEMA 932
>pir||S77614 phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) component
II - Synechococcus sp. (strain PCC 7942) (fragments)
Length = 321
Score = 105 bits (260), Expect = 2e-21
Identities = 49/92 (53%), Positives = 61/92 (66%)
Query: 3 PREEKIIRERLGREPNEVEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGV 62
P E I ERLGR PN+ E M VMWSEH YK+SR L PT+ +++GPGE+AGV
Sbjct: 21 PEEYDAIVERLGRHPNKAELGMFGVMWSEHCCYKNSRPLLSQFPTEGLRILVGPGENAGV 80
Query: 63 VKFDESTWIVIGIESHNHPSAVEPYGGAATGI 94
V + + +ESHNHPSAVEP+ GAATG+
Sbjct: 81 VDLGDGLHLAFKVESHNHPSAVEPFQGAATGV 112
>gb|AAF31730.1|AC020579_7 (AC020579) putative phosphoribosylformylglycinamidine synthase;
25509-29950 [Arabidopsis thaliana]
Length = 1387
Score = 103 bits (254), Expect = 8e-21
Identities = 168/653 (25%), Positives = 263/653 (39%), Gaps = 89/653 (13%)
Query: 71 IVIGIESHNHPSAVEPYGGAATGIGGIVRDILCMGARPIALLDPI-----------RFGP 119
I+ E+HN P AV PY GA TG GG +RD G + + P
Sbjct: 369 ILFTAETHNFPCAVAPYPGAETGAGGRIRDTHATGRGSFVVASTSGYCVGNLNMEGSYAP 428
Query: 120 LEKEKNRY---------LFEYVVKGIADYGNRIGVPTVGGETE-FDESLDN-----YTLV 164
E +Y + G +DYGN+ G P + G T F L + +
Sbjct: 429 WEDSSFQYPSNLASPLQILIDASNGASDYGNKFGEPMIQGYTRTFGMRLPSGDRREWLKP 488
Query: 165 NVVCVGIMKPEHLVHSYVTKP----GLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDR 220
+ GI + +H +++TK G+ +V +G R G+ G +S +N E D
Sbjct: 489 IMFSAGIGQIDH---THITKGEPEVGMLVVKIGGPAYRIGMGGGAASSMVSGQNDAELDF 545
Query: 221 SAVQIPDP-FTEKL--LIEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYA 277
+AVQ D ++KL ++ A +E + ++ D G GG E+ +G I A
Sbjct: 546 NAVQRGDAEMSQKLYRVVRACIEMGEKNPIISIHDQGAGGNCNVVKEIIYPQGAEIDIRA 605
Query: 278 DRVPLREPGMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYELEWAVVGEIIEEPRFV 337
V + + M+ LE+ +E QE+ V+ E E L I ++ L AV+G I R
Sbjct: 606 --VVVGDHTMSVLEIWGAEYQEQDAILVKAESREILQSICKRERLSMAVIGTINGGGRCT 663
Query: 338 VYWKGDKVA----------------DLPIE-LLTNVP--TIEWPMKEYKLEEDVETPDIA 378
+ D A DL +E +L ++P T ++ Y E P I
Sbjct: 664 LI---DSTAAAKCSKEGLPPPPPAVDLELEKVLGDMPKKTFKFNRIAYAREPLDIAPGIT 720
Query: 379 LSKAFDLVWSSPNIVAKRWVWEQYDHEVQGRTVVKPGF--------DAAVLK--INGEYG 428
L A V P++ +KR++ + D V G + D AV+ G
Sbjct: 721 LMDALKRVLRLPSVSSKRFLTTKVDRCVTGLVAQQQTVGPLQITLADVAVIAQTFTDLTG 780
Query: 429 LAITSDGNPSYCYLNPYHGAMGTVAEVVRNLVSVGAKPLALVD-----NLNFASP---ER 480
A P L+P A V E + NLV AK AL D N +A+ E
Sbjct: 781 GACAIGEQPIKGLLDPKAMARLAVGEALTNLV--WAKVTALSDVKASGNWMYAAKLEGEG 838
Query: 481 PEVYWSFVETVKGLADAAKAFDLAYVSGNVSFY--NEVVDRP----VKPTPVVAGIGKVK 534
+Y + + + + + A D S +++ + EVV P + I K
Sbjct: 839 SAMYDAAIALSEAMIELGIAIDGGKDSLSMAAHADGEVVKAPGNLVISAYVTCPDITKTV 898
Query: 535 LKDIPRGPRDGDVIAL-IGSTRRELGGSELYRVLGIKGGIAPRVNLEEEKGNAL-AILNL 592
D+ G DG ++ + + +R LGGS L +V G G P ++ N + L
Sbjct: 899 TPDLKLGGDDGILLHVDLAKGKRRLGGSALAQVFGQIGNDCPDLDDVPYLKNVFDGVQAL 958
Query: 593 IENDLVTFVHDVSRGGVAVALAELSAWFNVGVKAKFTSSFKSI-DFAFSESHG 644
I +LV+ HD+S GG+ V E++ N G+ S+ S+ + FSE G
Sbjct: 959 IAENLVSAGHDISDGGLVVTALEMAFAGNKGINLDLASNGISLFETLFSEELG 1011
>sp|Q58089|Y676_METJA PUTATIVE HYDROGENASE EXPRESSION/FORMATION PROTEIN MJ0676
>gi|2127980|pir||D64384 hydrogenase expression/formation
protein homolog - Methanococcus jannaschii
>gi|1591391|gb|AAB98671.1| (U67515) hydrogenase
expression/formation protein (hypE) [Methanococcus
jannaschii]
Length = 335
Score = 77.6 bits (188), Expect = 4e-13
Identities = 75/314 (23%), Positives = 138/314 (43%), Gaps = 46/314 (14%)
Query: 61 GVVKFDESTWIVIG-------IESHNHPSAVEPYGGAAT-GIGGIVRDILCMGARPIAL- 111
G+ D+S I IG ++ H P G + G V D+ MGA+P+AL
Sbjct: 36 GLESLDDSATIPIGDKEIVFTVDGHTVKPIFFPGGDIGRLAVSGTVNDLAVMGAKPLALS 95
Query: 112 ---LDPIRFGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVC 168
+ P F + EK +VK I + V + G+T+ + +D+ +++
Sbjct: 96 LSLIIPEGFNLEDLEK-------IVKSINETSKEAEVAIITGDTKVSDGVDDI-IISTAG 147
Query: 169 VGIMKPEHLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDP 228
+GI+ + + G +++ GN G HG+ + E +S V +
Sbjct: 148 IGIVDRGKAIRDCNVQEGDAIIVSGNI----GEHGLAILLSREGFDFETNIKSDVAPINK 203
Query: 229 FTEKLLIEATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREP--- 285
E++L E ++ A+KD GGL A +EMA K +G I+ D++P+ +
Sbjct: 204 LIERVLEEGI-------QINAMKDPTRGGLADALNEMAEKSNIGITIFEDKIPISDEVQS 256
Query: 286 -----GMTPLEVMISESQERMLFAVEPEDVEELAKIFEKYEL--EWAVVGEIIEEPRFVV 338
G+ PL + ++ +++ AV+ ED E +I ++ L ++G +E + V+
Sbjct: 257 ICDILGLDPLTI---ANEGKVVMAVKKEDAERCLEILREHPLGKNAEIIGYATKEHKGVI 313
Query: 339 YWK--GDKVADLPI 350
G ++ D+PI
Sbjct: 314 IETIVGRRIVDMPI 327
>pir||B69125 hydrogenase expression/formation protein HypE - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621250|gb|AAB84711.1| (AE000807) hydrogenase
expression/formation protein HypE [Methanobacterium
thermoautotrophicum]
Length = 376
Score = 75.3 bits (182), Expect = 2e-12
Identities = 75/295 (25%), Positives = 130/295 (43%), Gaps = 34/295 (11%)
Query: 71 IVIGIESHNHPSAVEPYGGAAT-GIGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLF 129
IVI + H P G + G V DI MGARP+A+ + + ++
Sbjct: 93 IVISTDGHTIDPLFFPGGDIGRIAVAGTVNDISVMGARPLAIANAMIISEGFPGED---L 149
Query: 130 EYVVKGIADYGNRIGVPTVGGETEFDES--LDNYTLVNVVCVGIMKPEHLVHSYVTKPGL 187
E ++K + GV V G+T+ E LD ++ +G++ V +PG
Sbjct: 150 ERIIKSMDAVSRETGVSIVTGDTKVMEQGKLDRM-VITTTGIGVVGRGETVRDSGLRPGD 208
Query: 188 KLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIEATLEAVYTGKV 247
K++L G+ G G+ + F + E D + V ++EA L G V
Sbjct: 209 KIILTGS-VGDHGMALMAFREGFGFDTDLESDVAPVWG--------IVEAALNV---GGV 256
Query: 248 KALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREP--------GMTPLEVMISESQE 299
A+KD GG+ A +EMA K G+G V+ D +P+RE G+ P EV ++
Sbjct: 257 TAMKDPTRGGIANALNEMADKSGVGMVLDEDSIPVREEVKAVSEMLGIDPYEV---ANEG 313
Query: 300 RMLFAVEPEDVEELAKIFEK--YELEWAVVGEIIEEPRFVVYWK--GDKVADLPI 350
+++ V+PE E++ Y E ++GE+ ++ ++ G ++ + P+
Sbjct: 314 KVIIGVDPEYAEDVLAAVRSAPYGEEARIIGEVTDDKHVILETSLGGRRILEAPV 368
>pir||E75040 hydrogenase expression/formation protein (hype) PAB0868 -
Pyrococcus abyssi (strain Orsay)
>gi|5458731|emb|CAB50218.1| (AJ248287) hydrogenase
expression/formation protein (hypE) [Pyrococcus abyssi]
Length = 336
Score = 74.9 bits (181), Expect = 3e-12
Identities = 79/287 (27%), Positives = 130/287 (44%), Gaps = 30/287 (10%)
Query: 58 EDAGVVKFDESTWIVIGIESHNHPSAVEPYGGAAT-GIGGIVRDILCMGARPIALLDPIR 116
+D + D IV I+ H P G + G V D+ MGA+PIAL +
Sbjct: 40 DDGATIPID-GRHIVFTIDGHTVKPLFFPGGDIGRLAVSGTVNDLAVMGAKPIALASSLI 98
Query: 117 FGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPEH 176
G ++ E ++K + + + VP V G+T+ E +N + V+ GI E
Sbjct: 99 IGEGFDSQD---LERILKSMDETAKEVPVPIVTGDTKVVE--ENVGIF-VITAGIGIAEK 152
Query: 177 LVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLIE 236
+ K G VLV +G G HG+ S + E E +S V P + +++
Sbjct: 153 PISDAGAKVG-DAVLV---SGTIGDHGIALMSHREGISFETELKSDVA---PTWD--VVK 203
Query: 237 ATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREP--------GMT 288
A +A+ + A+KD GGL+ A +EMA K +G +I +P+R G++
Sbjct: 204 AVADAIGWENIHAMKDPTRGGLSNALNEMARKANVGILIKESEIPIRPEVKAASEMLGIS 263
Query: 289 PLEVMISESQERMLFAVEPEDVEELAKIFEKYE--LEWAVVGEIIEE 333
P EV ++ +++ VE E EE + K E A++GE+I++
Sbjct: 264 PYEV---ANEGKVVMIVEREYAEEALEAMRKTEKGRNAAIIGEVIKD 307
>pir||D71121 probable hydrogenase expression/formation protein - Pyrococcus
horikoshii >gi|3257147|dbj|BAA29830.1| (AP000003) 336aa
long hypothetical hydrogenase expression/formation
protein [Pyrococcus horikoshii]
Length = 336
Score = 73.4 bits (177), Expect = 8e-12
Identities = 76/288 (26%), Positives = 131/288 (45%), Gaps = 32/288 (11%)
Query: 58 EDAGVVKFDESTWIVIGIESHNHPSAVEPYGGAAT-GIGGIVRDILCMGARPIALLDPIR 116
+D + F E +V I+ H P G + G V D+ MGA+P+AL +
Sbjct: 40 DDGATIPF-EGKHLVFTIDGHTVRPLFFPGGDIGRLAVSGTVNDLAVMGAKPLALASSLI 98
Query: 117 FGP-LEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVVCVGIMKPE 175
G + +K E ++K + + VP + G+T+ E DN + V+ GI E
Sbjct: 99 IGEGFDSDK----LEEILKSMNRTAKEVPVPIITGDTKVVE--DNIEIF-VITAGIGIAE 151
Query: 176 HLVHSYVTKPGLKLVLVGNRTGRDGIHGVTFASEELSENAEEEDRSAVQIPDPFTEKLLI 235
+ K G LVLV G G HG+ S + E E +S V P + ++
Sbjct: 152 KPISDAGAKVG-DLVLVN---GTIGDHGIALMSHREGISFETELKSDVA---PIWD--VV 202
Query: 236 EATLEAVYTGKVKALKDLGGGGLTCAASEMAGKKGLGAVIYADRVPLREP--------GM 287
+ +A+ + A+KD GGL+ A +EMA K +G ++ +P+R G+
Sbjct: 203 KTVADAIGWENIHAMKDPTRGGLSNALNEMARKADVGILVRESDIPIRPEVKAAGDMLGI 262
Query: 288 TPLEVMISESQERMLFAVEPEDVEELAKIFEKYE--LEWAVVGEIIEE 333
+P +V ++ +++ V+ E E+ + K E + A++GEII++
Sbjct: 263 SPYDV---ANEGKVIMVVDREYAEDALEAMRKTEKGKDAAIIGEIIKD 307
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.316 0.138 0.403
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 280332696
Number of Sequences: 2977
Number of extensions: 12735740
Number of successful extensions: 29427
Number of sequences better than 1.0e-10: 51
Number of HSP's better than 0.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 29064
Number of HSP's gapped (non-prelim): 103
length of query: 705
length of database: 189,106,746
effective HSP length: 57
effective length of query: 648
effective length of database: 154,992,987
effective search space: 100435455576
effective search space used: 100435455576
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 168 (69.9 bits)