BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1244 (bioF) DE:5-AMINOLEVULINIC ACID SYNTHASE (8
AMINO-7-OXONENANOATE SYNTHASE)
(398 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||F75017 probable glycine C-acetyltransferase (EC 2.3.1.29) P... 796 0.0
pir||E71454 probable glycine C-acetyltransferase (EC 2.3.1.29) P... 793 0.0
emb|CAC12314.1| (AL445066) probable glycine C-acetyltransferase ... 505 e-142
sp|O31777|KBL_BACSU 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (AK... 379 e-104
pir||A75286 probable glycine C-acetyltransferase (EC 2.3.1.29) D... 355 6e-97
sp|P22806|BIOF_BACSH 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 323 2e-87
pir||C82405 2-amino-3-ketobutyrate coenzyme A ligase VCA0886 [im... 318 6e-86
gi|7657118 glycine C-acetyltransferase (2-amino-3-ketobutyrate c... 312 6e-84
gb|AAF50007.1| (AE003543) CG10361 gene product [Drosophila melan... 310 2e-83
gi|7305083 glycine C-acetyltransferase (2-amino-3-ketobutyrate-c... 308 9e-83
pir||T34916 transferase - Streptomyces coelicolor >gi|2808751|em... 301 1e-80
emb|CAA29883.1| (X06690) aminoketobutyrate ligase (kbl) [Escheri... 300 2e-80
sp|P07912|KBL_ECOLI 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (AK... 300 2e-80
emb|CAB71247.1| (AL138598) 2-amino-3-ketobutyrate coenzyme A lig... 292 6e-78
sp|O66875|BIOF_AQUAE 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 284 1e-75
sp|P53556|BIOF_BACSU 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 283 3e-75
dbj|BAB07626.1| (AP001520) 8-amino-7-oxononanoate synthase [Baci... 272 7e-72
sp|Q58694|BIOF_METJA 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 271 9e-72
pir||S75730 8-amino-7-oxononanoate synthase (EC 2.3.1.47) - Syne... 270 2e-71
dbj|BAA35068.1| (AB015491) 5-aminolevulinate synthase [Rhodopseu... 257 2e-67
sp|P26505|HEM1_AGRRD 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINO... 246 4e-64
pir||G83582 8-amino-7-oxononanoate synthase PA0501 [imported] - ... 245 5e-64
sp|Q9ZCB8|HEM1_RICPR 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINO... 241 1e-62
pir||T38542 probable 5-aminolevulinate synthase (EC 2.3.1.37) SP... 236 3e-61
sp|Q06965|HEM0_RHOSH 5-AMINOLEVULINIC ACID SYNTHASE 2 (DELTA-AMI... 235 6e-61
sp|P08262|HEM1_BRAJA 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINO... 235 7e-61
gb|AAF44353.1|AF195767_1 (AF195767) 2-amino-3-ketobutyrate coenz... 234 1e-60
sp|P78698|HEM1_KLULA 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRI... 234 2e-60
sp|P43090|HEM0_OPSTA 5-AMINOLEVULINIC ACID SYNTHASE, ERYTHROID-S... 233 3e-60
gi|4758668 serine palmitoyltransferase, long chain base subunit ... 233 3e-60
pir||JC5180 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 cha... 233 4e-60
gi|6755656 serine palmitoyltransferase, long chain base subunit ... 233 4e-60
gb|AAD38391.1|AF152374_1 (AF152374) 5-aminolevulinic acid syntha... 232 5e-60
sp|P38092|HEM1_EMENI 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRI... 232 6e-60
gb|AAC37294.1| (L46348) delta-aminolevulinic acid synthetase [Pl... 232 6e-60
sp|P43091|HEM1_OPSTA 5-AMINOLEVULINIC ACID SYNTHASE, NONSPECIFIC... 230 2e-59
sp|O54694|LCB2_CRIGR SERINE PALMITOYLTRANSFERASE 2 (LONG CHAIN B... 230 2e-59
gi|6320438 5-aminolevulinate synthase; Hem1p [Saccharomyces cere... 228 9e-59
gb|AAA40724.1| (J04044) delta-aminolevulinate synthase precursor... 228 9e-59
gb|AAA91867.1| (M63245) mino levulinate synthase [Mus musculus] 228 1e-58
sp|Q92403|HEM1_AGABI 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRI... 228 1e-58
sp|Q04512|HEM1_RHOSH 5-AMINOLEVULINIC ACID SYNTHASE 1 (DELTA-AMI... 227 2e-58
gb|AAD41464.1|AF086786_1 (AF086786) erythroid-specific 5-aminole... 226 3e-58
emb|CAA39795.1| (X56352) delta-aminolevulinate synthase (erythr... 226 4e-58
gi|11420071 aminolevulinate, delta-, synthase 2 [Homo sapiens] >... 226 4e-58
pir||SYMSAL 5-aminolevulinate synthase (EC 2.3.1.37) precursor, ... 226 4e-58
gi|4557299 aminolevulinate, delta-, synthase 2; Aminolevulinate,... 226 4e-58
emb|CAB06076.1| (Z83821) 5-aminolevulinic acid synthase [Homo sa... 226 4e-58
gb|AAD20807.1| (AF073338) 5-aminolevulinate synthase [Glycera di... 226 5e-58
gi|6978485 aminolevulinate synthase 2, delta [Rattus norvegicus]... 225 6e-58
gi|4502025 aminolevulinate, delta-, synthase 1 [Homo sapiens] >g... 225 8e-58
gi|11449702 aminolevulinate, delta-, synthase 1 [Homo sapiens] 225 8e-58
pir||C49845 5-aminolevulinate synthase (EC 2.3.1.37) HemA - Rhod... 224 1e-57
sp|P08680|HEM0_MOUSE 5-AMINOLEVULINIC ACID SYNTHASE, ERYTHROID-S... 223 2e-57
gb|AAD20806.1| (AF073337) 5-aminolevulinate synthase [Delphinapt... 223 2e-57
sp|P13195|HEM1_RAT 5-AMINOLEVULINIC ACID SYNTHASE, NONSPECIFIC, ... 222 4e-57
gb|AAC72835.1| (AF095747) aminolevulinate synthase erythroid spe... 222 4e-57
pir||JX0278 5-aminolevulinate synthase (EC 2.3.1.37) precursor, ... 221 9e-57
gb|AAD20809.1| (AF073340) 5-aminolevulinate synthase [Strongyloc... 221 9e-57
emb|CAA74915.1| (Y14577) delta-aminolevulinate synthase [Drosoph... 221 1e-56
sp|O94069|HEM1_CANAL 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRI... 221 1e-56
emb|CAB44316.1| (AJ242659) serine palmitoyltransferase [Solanum ... 220 2e-56
sp|P43089|HEM1_PARDE 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINO... 220 2e-56
sp|P18079|HEM1_RHOCA 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINO... 219 4e-56
emb|CAB65865.1| (AL109983) dJ718P11.1.1 (novel class II aminotra... 219 6e-56
emb|CAA68506.1| (Y00451) 5-aminolevulinate synthase precursor [H... 218 8e-56
pir||B31452 5-aminolevulinate synthase (EC 2.3.1.37), hepatic - ... 218 1e-55
sp|P07997|HEM1_CHICK 5-AMINOLEVULINIC ACID SYNTHASE, NONSPECIFIC... 218 1e-55
gb|AAD20810.1| (AF073341) 5-aminolevulinate synthase [Myxine glu... 218 1e-55
pir||T49274 serine palmitoyltransferase-like protein - Arabidops... 218 1e-55
pir||F70701 probable bioF2 protein - Mycobacterium tuberculosis ... 217 1e-55
pir||D82692 8-amino-7-oxononanoate synthase XF1357 [imported] - ... 217 2e-55
emb|CAA45489.1| (X64131) acyl-transferase [Sinorhizobium meliloti] 215 5e-55
pir||T48458 8-amino-7-oxononanoate synthase-like protein - Arabi... 215 9e-55
gb|AAD20808.1| (AF073339) 5-aminolevulinate synthase [Sepia offi... 214 1e-54
gb|AAD20805.1| (AF073336) 5-aminolevulinate synthase [Limulus po... 214 2e-54
gb|AAF21252.1|AF053456_1 (AF053456) serine palmitoyl Co-A transf... 213 3e-54
pir||T25261 probable glycine C-acetyltransferase (EC 2.3.1.29) T... 212 6e-54
pir||T25126 serine C-palmitoyltransferase (EC 2.3.1.50) T22G5.5 ... 212 8e-54
dbj|BAA97234.1| (AB025633) serine palmitoyltransferase [Arabidop... 210 3e-53
dbj|BAB03231.1| (AB046384) serine palmitoyltransferase [Arabidop... 210 3e-53
sp|Q09925|LCB2_SCHPO SERINE PALMITOYLTRANSFERASE 2 (LONG CHAIN B... 208 9e-53
gb|AAD21558.1| (AF088896) aminolevulinic acid synthase [Zymomona... 208 9e-53
gb|AAA91866.1| (M63244) mino levulinate synthase [Mus musculus] 207 2e-52
pir||SYCHLE 5-aminolevulinate synthase (EC 2.3.1.37) precursor, ... 206 3e-52
sp|P18080|HEM0_CHICK 5-AMINOLEVULINIC ACID SYNTHASE, ERYTHROID-S... 206 3e-52
pir||T49275 serine palmitoyltransferase-like protein - Arabidops... 206 3e-52
pir||T34918 polyketide synthase - Streptomyces coelicolor >gi|28... 204 1e-51
gb|AAA53669.1| (L33931) ScS1p [Saccharomyces cerevisiae] 202 5e-51
pir||JC5181 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 cha... 202 5e-51
gi|6320267 Probable component of serine palmitoyltransferase, wh... 202 7e-51
sp|P48241|LCB2_KLULA SERINE PALMITOYLTRANSFERASE 2 (LONG CHAIN B... 196 5e-49
sp|P12998|BIOF_ECOLI 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 194 1e-48
dbj|BAA83721.1| (AB017359) serine palmitoyl transferase LCB2 sub... 193 3e-48
gb|AAF44946.1|AE003406_151 (AE003416) symbol=lace; synonym=BG:DS... 193 3e-48
sp|P44422|BIOF_HAEIN 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 191 1e-47
sp|Q47829|BIOF_ERWHE 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 190 2e-47
pir||I38873 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 cha... 189 7e-47
pir||PC4253 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 cha... 189 7e-47
pir||A82239 8-amino-7-oxononanoate synthase VC1113 [imported] - ... 188 1e-46
sp|O06621|BIOF_MYCTU 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 187 3e-46
emb|CAC01467.1| (AL391014) 8-amino-7-oxononanoate synthase [Stre... 187 3e-46
pir||H81830 8-amino-7-oxononanoate synthase (EC 2.3.1.47) NMA201... 182 5e-45
pir||T29503 serine C-palmitoyltransferase (EC 2.3.1.50) F43H9.2 ... 180 3e-44
pir||C81194 8-amino-7-oxononanoate synthase (EC 2.3.1.47) NMB047... 179 6e-44
sp|P36570|BIOF_SERMA 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 178 1e-43
gi|6678125 serine palmitoyltransferase, long chain base subunit ... 175 1e-42
gb|AAC02264.1| (AF003823) serine palmitoyltransferase LCB1 subun... 174 1e-42
sp|P45487|BIOF_MYCLE 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-A... 171 9e-42
emb|CAB16844.1| (Z99708) serine C-palmitoyltransferase like prot... 171 1e-41
sp|O54695|LCB1_CRIGR SERINE PALMITOYLTRANSFERASE 1 (LONG CHAIN B... 171 2e-41
gi|5454084 serine palmitoyltransferase, long chain base subunit ... 170 2e-41
gb|AAF58417.1| (AE003819) CG4016 gene product [Drosophila melano... 165 7e-40
pir||G72004 8-amino-7-oxononanoate synthase (EC 2.3.1.47) - Chla... 160 3e-38
pir||F81449 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Cj0306... 158 9e-38
pir||T25557 hypothetical protein C23H3.4 - Caenorhabditis elegan... 156 4e-37
pir||S50064 bioF protein - Synechocystis sp. (fragment) >gi|5056... 125 6e-28
pir||T40091 probable serine palmitoyltransferase - fission yeast... 123 3e-27
sp|P37419|KBL_SALTY 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (AK... 116 3e-25
pir||H82448 aminotransferase, class II VCA0523 [imported] - Vibr... 115 9e-25
pir||C81734 8-amino-7-oxononanoate synthase (EC 2.3.1.47) TC0158... 89 7e-17
gb|AAG27130.2|AF155773_3 (AF155773) Fum8p [Gibberella moniliformis] 80 4e-14
>pir||F75017 probable glycine C-acetyltransferase (EC 2.3.1.29) PAB1244 -
Pyrococcus abyssi (strain Orsay)
>gi|5459094|emb|CAB50580.1| (AJ248288) 5-AMINOLEVULINIC
ACID SYNTHASE (8 AMINO-7-OXONENANOATE SYNTHASE)
[Pyrococcus abyssi]
Length = 398
Score = 796 bits (2034), Expect = 0.0
Identities = 398/398 (100%), Positives = 398/398 (100%)
Query: 1 MVLMGKLDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPK 60
MVLMGKLDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPK
Sbjct: 1 MVLMGKLDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPK 60
Query: 61 IKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAIS 120
IKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAIS
Sbjct: 61 IKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAIS 120
Query: 121 ALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVT 180
ALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVT
Sbjct: 121 ALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVT 180
Query: 181 DGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMG 240
DGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMG
Sbjct: 181 DGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMG 240
Query: 241 TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKK 300
TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKK
Sbjct: 241 TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKK 300
Query: 301 LWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTV 360
LWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTV
Sbjct: 301 LWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTV 360
Query: 361 PLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFLK 398
PLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFLK
Sbjct: 361 PLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFLK 398
>pir||E71454 probable glycine C-acetyltransferase (EC 2.3.1.29) PH0292 -
Pyrococcus horikoshii >gi|3256681|dbj|BAA29364.1|
(AP000001) 398aa long hypothetical 5-aminolevulinic acid
synthase (8 amino-7-oxonenanoate synthase) [Pyrococcus
horikoshii]
Length = 398
Score = 793 bits (2025), Expect = 0.0
Identities = 394/398 (98%), Positives = 398/398 (99%)
Query: 1 MVLMGKLDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPK 60
MVLMGKLDWIKEELEELKKKGLYVTIRVLQSAQGPW+VVNGKRVLNMCSNNYLGLAAHPK
Sbjct: 1 MVLMGKLDWIKEELEELKKKGLYVTIRVLQSAQGPWIVVNGKRVLNMCSNNYLGLAAHPK 60
Query: 61 IKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAIS 120
IKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAIS
Sbjct: 61 IKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAIS 120
Query: 121 ALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVT 180
ALLRKGEDG+FLSEELNHASIIDGMRLSGAPKVIYKHLD+DDLKKKLEENKDKKKKIIVT
Sbjct: 121 ALLRKGEDGVFLSEELNHASIIDGMRLSGAPKVIYKHLDVDDLKKKLEENKDKKKKIIVT 180
Query: 181 DGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMG 240
DGVFSMDGDLAPLPEIVE+AEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMG
Sbjct: 181 DGVFSMDGDLAPLPEIVEVAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMG 240
Query: 241 TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKK 300
TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKK
Sbjct: 241 TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKK 300
Query: 301 LWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTV 360
LWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTV
Sbjct: 301 LWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTV 360
Query: 361 PLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFLK 398
PLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFLK
Sbjct: 361 PLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFLK 398
>emb|CAC12314.1| (AL445066) probable glycine C-acetyltransferase [Thermoplasma
acidophilum]
Length = 393
Score = 505 bits (1286), Expect = e-142
Identities = 242/391 (61%), Positives = 308/391 (77%), Gaps = 3/391 (0%)
Query: 4 MGKLDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKE 63
M +L W++EEL LK +G YV IR ++SAQG WV + GK+VLNMCSNNYLG A HP+ K+
Sbjct: 1 MQRLSWVEEELSALKAEGRYVPIRTIESAQGSWVTIGGKKVLNMCSNNYLGFANHPETKK 60
Query: 64 AAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALL 123
AAI AI YGVGAGAVR+IAGT E+H LEEK+AKFK E+A+++Q G AN+G I AL+
Sbjct: 61 AAIEAIEQYGVGAGAVRSIAGTDEIHARLEEKIAKFKHMESALVYQGGLLANVGTIPALV 120
Query: 124 RKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDK-KKKIIVTDG 182
G+D + SEELNHASIIDG RLS A +++YKHL ++DL+K++ EN+ KK +++TDG
Sbjct: 121 --GKDDVIFSEELNHASIIDGTRLSSAKRIVYKHLSVEDLEKQIRENRSAFKKALVITDG 178
Query: 183 VFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTL 242
VFSMDGD+APLPEI E+AE+ D +VYVDDAHGEGVLG HGRGIV++F+L D+VD EMGT
Sbjct: 179 VFSMDGDIAPLPEITEVAEKNDVMVYVDDAHGEGVLGDHGRGIVNYFHLEDRVDIEMGTF 238
Query: 243 SKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLW 302
SKA G +GG+VAG + I+ LKQ+ARPFLFSSA+NP D AA + A+EIL+K D L+KKLW
Sbjct: 239 SKALGSMGGFVAGSADLIDLLKQKARPFLFSSALNPGDAAAVLKAIEILEKDDSLIKKLW 298
Query: 303 DNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPL 362
N+ L+K L D+GY+ G++K PITPV++ DEK E S+ LY+E ++FA IVYPTVP
Sbjct: 299 HNSDILKKSLSDVGYNTGHSKTPITPVIIGDEKKTVELSKMLYDEKDVFASPIVYPTVPK 358
Query: 363 GTARIRLEPSAAHTKEDLKLVIDAFEDLGKK 393
GTARIRL PSA HT D+K+ +DAF DLGKK
Sbjct: 359 GTARIRLMPSAVHTDADIKVAVDAFTDLGKK 389
>sp|O31777|KBL_BACSU 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (AKB LIGASE) (GLYCINE
ACETYLTRANSFERASE) >gi|7433705|pir||G69647 glycine
C-acetyltransferase (EC 2.3.1.29) kbl - Bacillus
subtilis >gi|2634072|emb|CAB13573.1| (Z99112)
2-amino-3-ketobutyrate CoA ligase (glycine acetyl
transferase) [Bacillus subtilis]
Length = 392
Score = 379 bits (964), Expect = e-104
Identities = 187/392 (47%), Positives = 276/392 (69%), Gaps = 3/392 (0%)
Query: 6 KLDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAA 65
+ +++K EL +K+ + I+ L+S QGP V VN ++V+ + SNNYLG +HP++ AA
Sbjct: 4 EFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQLSSNNYLGFTSHPRLINAA 63
Query: 66 IRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRK 125
A+ YG G G+VRTIAGT +H ELE+KLA FKK EAA++FQSG+ N G +S++L K
Sbjct: 64 QEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEAALVFQSGFTTNQGVLSSILSK 123
Query: 126 GEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFS 185
+ I +S+ELNHASIIDG+RL+ A K +Y+H++M DL++ L ++ + + ++IVTDGVFS
Sbjct: 124 --EDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLERVLRKSMNYRMRLIVTDGVFS 181
Query: 186 MDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKA 245
MDG++APLP+IVELAE+YDA V VDDAH GVLG +GRG V+HF L +V ++GTLSKA
Sbjct: 182 MDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENGRGTVNHFGLDGRVHIQVGTLSKA 241
Query: 246 FGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNT 305
GV+GGY AG + I+YL+ + RPFLFS++ P AA + A+++L + + +++LW+NT
Sbjct: 242 IGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAVTAACMEAIDVLLEEPEHMERLWENT 301
Query: 306 HFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTA 365
+ + L +G L ++ PI P+++ DE +A++FS +L +FAQ+IV+PTV G A
Sbjct: 302 AYFKAMLVKMGLTLTKSETPILPILIGDEGVAKQFSDQLLSR-GVFAQSIVFPTVAKGKA 360
Query: 366 RIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
RIR +A HTK++L +D E K+ L
Sbjct: 361 RIRTIITAEHTKDELDQALDVIEKTAKELQLL 392
>pir||A75286 probable glycine C-acetyltransferase (EC 2.3.1.29) DR2346
[similarity] - Deinococcus radiodurans (strain R1)
>gi|6460157|gb|AAF11891.1|AE002065_8 (AE002065)
aminotransferase, class II [Deinococcus radiodurans]
Length = 424
Score = 355 bits (901), Expect = 6e-97
Identities = 183/389 (47%), Positives = 262/389 (67%), Gaps = 4/389 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAI 69
++++L L++ GL ++ RVL + Q V+G+ V+N+ SNNYLG A HP++KE A + +
Sbjct: 38 LRQDLAGLRESGLLISPRVLDAPQRARTRVDGREVVNLASNNYLGFADHPRLKERAAQYL 97
Query: 70 LDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDG 129
+GVGAGAVRTIAGT+ +H + E +LA FK +A++ SG++ N G + LLR+G+
Sbjct: 98 QQWGVGAGAVRTIAGTLRIHEDFERQLADFKHTGSALVLHSGFSTNQGVLGGLLREGD-- 155
Query: 130 IFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGD 189
+ +S+ELNHASIIDG+RL+ A K IYKH D DL + L EN + K++VTDGVFSMDGD
Sbjct: 156 LVVSDELNHASIIDGLRLTKATKKIYKHADPADLDRVLRENPSEGLKLVVTDGVFSMDGD 215
Query: 190 LAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVD-FEMGTLSKAFGV 248
+APL ++VE+A +Y A+ YVDDAHG GV+G GRG V HF D ++GTLSKA+G
Sbjct: 216 VAPLDKLVEVARRYGAVTYVDDAHGSGVMGEAGRGTVHHFGFEYADDVIQVGTLSKAWGG 275
Query: 249 IGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFL 308
+GGY AG + E L RARP+LFS+A P V A AA++ +Q+ L+++LWDNT F
Sbjct: 276 VGGYAAGHPDLRELLINRARPYLFSTAQPPAVVGALAAALDEVQRDPSLMERLWDNTRFF 335
Query: 309 QKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIR 368
+ L LG+D + PITPV+ + A E SRRL+ + IFA + +PTVP ARIR
Sbjct: 336 KAELGRLGFDTLGSVTPITPVVFGEASAAFEASRRLF-DLGIFAVGLGFPTVPRDLARIR 394
Query: 369 LEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
+A HT++DL+ + A++ +G+ G +
Sbjct: 395 NIVTAEHTRDDLEQALSAYQQVGRDLGVI 423
>sp|P22806|BIOF_BACSH 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|98180|pir||JQ0512 8-amino-7-oxononanoate synthase
(EC 2.3.1.47) - Bacillus sphaericus
>gi|142595|gb|AAA22271.1| (M29291)
7-keto-8-aminopelargonic acid synthetase (bioF)
[Bacillus sphaericus]
Length = 389
Score = 323 bits (819), Expect = 2e-87
Identities = 171/390 (43%), Positives = 248/390 (62%), Gaps = 3/390 (0%)
Query: 8 DWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIR 67
D + EL+ ++++GL +R+ + VV+NGK+ L SNNYLGLA ++K+ A
Sbjct: 3 DRFRRELQVIEEQGLTRKLRLFSTGNESEVVMNGKKFLLFSSNNYLGLATDSRLKKKATE 62
Query: 68 AILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGE 127
I YG GAG R G ++H +LE ++A FKK EAAI+F SGY AN+G IS++++ G
Sbjct: 63 GISKYGTGAGGSRLTTGNFDIHEQLESEIADFKKTEAAIVFSSGYLANVGVISSVMKAG- 121
Query: 128 DGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMD 187
D IF S+ NHASIIDG RLS A ++Y+H DM DL++KL ++ K IVTDGVFSMD
Sbjct: 122 DTIF-SDAWNHASIIDGCRLSKAKTIVYEHADMVDLERKLRQSHGDGLKFIVTDGVFSMD 180
Query: 188 GDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFG 247
GD+APLP+IVELA++Y A + +DDAH GVLG+ G G D+F L D++DF +GTLSKA G
Sbjct: 181 GDIAPLPKIVELAKEYKAYIMIDDAHATGVLGNDGCGTADYFGLKDEIDFTVGTLSKAIG 240
Query: 248 VIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHF 307
GG+V+ A YL AR F+F +A++P + AA + I+Q + K+L N +
Sbjct: 241 AEGGFVSTSSIAKNYLLNNARSFIFQTALSPSAIEAAREGISIIQNEPERRKQLLKNAQY 300
Query: 308 LQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARI 367
L+ L + G+ + + PI +++ A +FS +L +E +F AI PTVP G++R+
Sbjct: 301 LRLKLEESGFVMKEGETPIISLIIGGSHEAMQFSAKLLDE-GVFIPAIRPPTVPKGSSRL 359
Query: 368 RLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
R+ A HT E L +VI + +GK+ G +
Sbjct: 360 RITVMATHTIEQLDMVISKIKKIGKEMGIV 389
>pir||C82405 2-amino-3-ketobutyrate coenzyme A ligase VCA0886 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9658320|gb|AAF96784.1| (AE004416)
2-amino-3-ketobutyrate coenzyme A ligase [Vibrio
cholerae]
Length = 397
Score = 318 bits (807), Expect = 6e-86
Identities = 171/392 (43%), Positives = 262/392 (66%), Gaps = 7/392 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVN-GKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
I+ +LEE+K +GLY + RV+ S Q V ++ G++VLN C+NNYLGLA HP + EAA +
Sbjct: 9 IRTQLEEVKAEGLYKSERVITSQQQAAVEISTGEQVLNFCANNYLGLANHPALIEAAKQG 68
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
+ +G G +VR I GT ++H +LE+KL++F +E IL+ S ++AN G LL K ED
Sbjct: 69 MDSHGFGMASVRFICGTQDIHKQLEQKLSQFLGKEDTILYTSCFDANAGLFETLLDK-ED 127
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKL--EENKDKKKKIIVTDGVFSM 186
I +S+ LNHASIIDG+RL A + Y + +M +L+++L + + K+IVTDGVFSM
Sbjct: 128 AI-ISDALNHASIIDGVRLCKAMRFRYSNNNMAELEEQLIAADAAGARHKLIVTDGVFSM 186
Query: 187 DGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF 246
DG +A LP I +LA++Y+A+V VDD+H G +G++GRG ++ ++ D++D GTL KA
Sbjct: 187 DGVVANLPAICDLADKYNALVMVDDSHAVGFMGANGRGTHEYHDVIDRIDIITGTLGKAM 246
Query: 247 G-VIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNT 305
G GGY +G +E I++L+QR+RP+LFS+++ P VAA++ +++LQ+S DL ++LW+N
Sbjct: 247 GGASGGYTSGKKEVIDWLRQRSRPYLFSNSVAPSIVAASLRVLDLLQESGDLRERLWENA 306
Query: 306 HFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTA 365
+ + G+ +G H I P+ML D K+A EF+ R + I+ +P VP G A
Sbjct: 307 AHFRTRMEAAGFTMGGADHAIIPIMLGDAKVAAEFAERALAK-GIYVIGFSFPVVPKGQA 365
Query: 366 RIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
RIR + SAAH++E L IDAF ++G+ G +
Sbjct: 366 RIRTQMSAAHSREQLDKAIDAFIEVGRDMGLI 397
>gi|7657118 glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A
ligase); 2-amino-3-ketobutyrate-CoA ligase [Homo
sapiens] >gi|11418091|ref|XP_009974.1| glycine
C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A
ligase) [Homo sapiens] >gi|6685545|sp|O75600|KBL_HUMAN
2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL
PRECURSOR (AKB LIGASE) (GLYCINE ACETYLTRANSFERASE)
>gi|3342906|gb|AAC27720.1| (AF077740)
2-amino-3-ketobutyrate-CoA ligase [Homo sapiens]
>gi|4808241|emb|CAB42830.1| (Z97630) dJ466N1.2 (glycine
C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A
ligase)) [Homo sapiens]
Length = 419
Score = 312 bits (790), Expect = 6e-84
Identities = 167/391 (42%), Positives = 246/391 (62%), Gaps = 6/391 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKR--VLNMCSNNYLGLAAHPKIKEAAIR 67
++ ELE ++ G + + RV+ S QGP + V+G +LN C+NNYLGL++HP++ +A ++
Sbjct: 31 LEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQ 90
Query: 68 AILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGE 127
A+ ++G G +VR I GT +H LE K+A+F +RE AIL+ S Y+AN G ALL E
Sbjct: 91 ALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTP-E 149
Query: 128 DGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMD 187
D + LS+ELNHASIIDG+RL A K Y+HLDM DL+ KL+E + + +++ TDG FSMD
Sbjct: 150 DAV-LSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMD 208
Query: 188 GDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF- 246
GD+APL EI LA +Y A+V++D+ H G LG GRG + + D+V TL KA
Sbjct: 209 GDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALG 268
Query: 247 GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTH 306
G GGY GP + L+QRARP+LFS+++ P V A A+++L S+ +V+ + T
Sbjct: 269 GASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQ 328
Query: 307 FLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTAR 366
+ + G+ + HPI PVML D +LA + + + IF YP VP G AR
Sbjct: 329 RFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKR-GIFVIGFSYPVVPKGKAR 387
Query: 367 IRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
IR++ SA H++ED+ ++AF ++G+ G L
Sbjct: 388 IRVQISAVHSEEDIDRCVEAFVEVGRLHGAL 418
>gb|AAF50007.1| (AE003543) CG10361 gene product [Drosophila melanogaster]
Length = 404
Score = 310 bits (786), Expect = 2e-83
Identities = 163/389 (41%), Positives = 249/389 (63%), Gaps = 7/389 (1%)
Query: 13 ELEELKKKGLYVTIRVLQSAQGPWVVVNG--KRVLNMCSNNYLGLAAHPKIKEAAIRAIL 70
+L +K G + R++ S+Q + V G K++LN C+NNYLGLA +P+I E + + +
Sbjct: 20 QLAGIKDAGTFKAERIITSSQSTQITVQGSDKKILNFCANNYLGLANNPEIVEHSQKLLE 79
Query: 71 DYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGI 130
YG G +VR I GT ++H +LE+K+A+F RE IL+ S ++AN G A+L ED +
Sbjct: 80 QYGAGLSSVRFICGTQDIHKQLEKKIAQFHGREDTILYASCFDANAGIFEAILTP-EDAV 138
Query: 131 FLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDL 190
F S+ELNHASIIDG+RL A K Y+H D+ DL+++L+ + D + K+I TDGVFSMDG++
Sbjct: 139 F-SDELNHASIIDGIRLCKAKKQRYRHRDLGDLEEQLKAS-DARLKLIATDGVFSMDGNI 196
Query: 191 APLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF-GVI 249
APL IVELA +Y+A+V+VD+ H G G+ GRG ++ N+ +VD TL KA G
Sbjct: 197 APLARIVELARKYNALVFVDECHATGFFGATGRGTEEYDNVMGEVDIINSTLGKALGGAS 256
Query: 250 GGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQ 309
GGY GP E I +L+Q++RP+LFS+ + P VA + +++L +S +L +++ NT +
Sbjct: 257 GGYTTGPAELISFLRQKSRPYLFSNTLPPAVVAVGLKVMDMLLQSSELTQRVQSNTQRFR 316
Query: 310 KGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRL 369
+ + G+ + HPI PVML D +LA +F+ + I+ YP VP G ARIR+
Sbjct: 317 QAMTKAGFTIAGENHPICPVMLGDARLASQFADEMLTR-GIYVIGFSYPVVPQGKARIRV 375
Query: 370 EPSAAHTKEDLKLVIDAFEDLGKKTGFLK 398
+ SAAHT+ ++ I+AF ++G+ +K
Sbjct: 376 QISAAHTEAEIDRAINAFIEVGRSLKVIK 404
>gi|7305083 glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A
ligase); aminoacetone synthase [Mus musculus]
>gi|6685546|sp|O88986|KBL_MOUSE 2-AMINO-3-KETOBUTYRATE
COENZYME A LIGASE, MITOCHONDRIAL PRECURSOR (AKB LIGASE)
(GLYCINE ACETYLTRANSFERASE) >gi|4093159|gb|AAC99774.1|
(AF093403) 2-amino-3-ketobutyrate-coenzyme A ligase [Mus
musculus]
Length = 416
Score = 308 bits (780), Expect = 9e-83
Identities = 163/391 (41%), Positives = 245/391 (61%), Gaps = 6/391 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKR--VLNMCSNNYLGLAAHPKIKEAAIR 67
+ ELE ++ G + + RV+ S QGP + V+G +LN C+NNYLGL++HP + +A ++
Sbjct: 28 LDSELEGIRGAGTWKSERVITSRQGPSIRVDGISGGILNFCANNYLGLSSHPAVIQAGLQ 87
Query: 68 AILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGE 127
+ ++G G + R I GT +H LE K+A F +RE AIL+ S ++AN G ALL E
Sbjct: 88 TLEEFGAGLSSTRFICGTQSIHKNLEAKIAHFHQREDAILYPSCFDANAGLFEALLTP-E 146
Query: 128 DGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMD 187
D + LS+ELNHASIIDG+RL A K Y+HLDM DL+ KL+E + + +++ TDG FSMD
Sbjct: 147 DAV-LSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLKEAQKHRLRLVATDGAFSMD 205
Query: 188 GDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF- 246
GD+APL +I LA QY A+V+VD+ H G LG GRG + + D+V TL KA
Sbjct: 206 GDIAPLQDICRLAAQYGALVFVDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALG 265
Query: 247 GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTH 306
G GGY GPE + L+QR+RP+LFS+++ P V A A+++L +S+ +++ + T
Sbjct: 266 GASGGYTTGPEPLVSLLRQRSRPYLFSNSLPPAVVGCASKALDLLMESNAIIQSMAAKTR 325
Query: 307 FLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTAR 366
+ + G+ + HPI PVML D +L+ + + + ++ IF YP VP G AR
Sbjct: 326 RFRSKMEAAGFTVSGADHPICPVMLGDARLSSQMADDMLKK-GIFVIGFSYPVVPKGKAR 384
Query: 367 IRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
IR++ SA H++ED+ ++AF ++G+ G L
Sbjct: 385 IRVQISAVHSEEDIDRCVEAFVEVGRLHGAL 415
>pir||T34916 transferase - Streptomyces coelicolor >gi|2808751|emb|CAA16181.1|
(AL021409) transferase [Streptomyces coelicolor A3(2)]
Length = 640
Score = 301 bits (762), Expect = 1e-80
Identities = 156/358 (43%), Positives = 225/358 (62%), Gaps = 5/358 (1%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
+ L SNNYLGLA HP + EA + A YG R I GT LH ELE +LA FK+
Sbjct: 282 REFLMFASNNYLGLANHPSVIEAVVDATRTYGATHTGSRFIGGTNMLHKELERRLAAFKQ 341
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
R A I++ GY+ANLGAISAL++ + + + LNH SI+DG RLSGA + IY+H DM
Sbjct: 342 RPACIVYPGGYSANLGAISALVKSYDT--LVVDRLNHMSIVDGARLSGAVRKIYRHNDMA 399
Query: 162 DLKKKLEENKDKKK--KIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLG 219
DL++ L + + ++IV DGVFSM GD+ LPEIV LA++YDA V +DDAH GVLG
Sbjct: 400 DLERILSRSAAEGTGGRLIVADGVFSMHGDVCDLPEIVRLAKEYDARVMIDDAHATGVLG 459
Query: 220 SHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPP 279
G G +HF L +VD E+GT+SK +GG+V G EE +EYL+ + ++F++ +
Sbjct: 460 VRGSGTAEHFGLKGEVDLELGTMSKTLAGMGGFVVGEEEVVEYLRYYSNSYVFAANIPAG 519
Query: 280 DVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQE 339
A IA++++++ + +K+LW N L+ L D G+DL +++ I P+++ DE+ A E
Sbjct: 520 VAAGLIASIDVIESEPERLKRLWTNIGTLRDRLLDAGFDLEHSESAILPIVIGDERRAME 579
Query: 340 FSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
R + +F Q +VYP VPLG AR+R+ + HT +DL+L + F D ++TG L
Sbjct: 580 LGRAV-RARGLFCQTVVYPGVPLGDARLRVSVTCEHTPQDLELAAEIFVDAARETGVL 636
>emb|CAA29883.1| (X06690) aminoketobutyrate ligase (kbl) [Escherichia coli]
Length = 398
Score = 300 bits (760), Expect = 2e-80
Identities = 163/392 (41%), Positives = 246/392 (62%), Gaps = 7/392 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVV-NGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
+ +LE + +GL+ R++ SAQ + V +G +V+N C+NNYLGLA HP + AA
Sbjct: 9 LTNDLETARAEGLFKEERIITSAQQADITVADGSQVINFCANNYLGLANHPDLIAAAKAG 68
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
+ +G G +VR I GT + H ELE+KLA F E AIL+ S ++AN G LL G +
Sbjct: 69 MDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFETLL--GAE 126
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKK--IIVTDGVFSM 186
+S+ LNHASIIDG+RL A + Y + DM +L+ +L+E +++ + +I TDG+FSM
Sbjct: 127 DAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEARERGARHVLIATDGLFSM 186
Query: 187 DGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF 246
DG +A L + +LA++YDA+V VDD+H G +G +GRG ++ ++ +VD GTL KA
Sbjct: 187 DGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKAL 246
Query: 247 G-VIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNT 305
G GGY A +E +E+L+QR+RP+LFS+++ P VAA+I +E+++ +L +LW N
Sbjct: 247 GGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANA 306
Query: 306 HFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTA 365
++ + G+ L H I PVML D +AQ+F+R L +E I+ YP VP G A
Sbjct: 307 RQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKE-GIYVTGFFYPVVPKGQA 365
Query: 366 RIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
RIR + SAAHT E + ++AF +GK+ G +
Sbjct: 366 RIRTQMSAAHTPEQITRAVEAFTRIGKQLGVI 397
>sp|P07912|KBL_ECOLI 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (AKB LIGASE) (GLYCINE
ACETYLTRANSFERASE) >gi|7427917|pir||XUECGA glycine
C-acetyltransferase (EC 2.3.1.29) - Escherichia coli
>gi|466755|gb|AAB18594.1| (U00039) glycine
acetyltransferase [Escherichia coli]
>gi|1790046|gb|AAC76641.1| (AE000439)
2-amino-3-ketobutyrate CoA ligase (glycine
acetyltransferase) [Escherichia coli K12]
Length = 398
Score = 300 bits (759), Expect = 2e-80
Identities = 164/392 (41%), Positives = 244/392 (61%), Gaps = 7/392 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVV-NGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
+ +LE + +GL+ R++ SAQ + V +G V+N C+NNYLGLA HP + AA
Sbjct: 9 LTNDLETARAEGLFKEERIITSAQQADITVADGSHVINFCANNYLGLANHPDLIAAAKAG 68
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
+ +G G +VR I GT + H ELE+KLA F E AIL+ S ++AN G LL G +
Sbjct: 69 MDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFETLL--GAE 126
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKK--IIVTDGVFSM 186
+S+ LNHASIIDG+RL A + Y + DM +L+ +L+E ++ + +I TDGVFSM
Sbjct: 127 DAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLIATDGVFSM 186
Query: 187 DGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF 246
DG +A L + +LA++YDA+V VDD+H G +G +GRG ++ ++ +VD GTL KA
Sbjct: 187 DGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKAL 246
Query: 247 G-VIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNT 305
G GGY A +E +E+L+QR+RP+LFS+++ P VAA+I +E+++ +L +LW N
Sbjct: 247 GGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANA 306
Query: 306 HFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTA 365
++ + G+ L H I PVML D +AQ+F+R L +E I+ YP VP G A
Sbjct: 307 RQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKE-GIYVTGFFYPVVPKGQA 365
Query: 366 RIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
RIR + SAAHT E + ++AF +GK+ G +
Sbjct: 366 RIRTQMSAAHTPEQITRAVEAFTRIGKQLGVI 397
>emb|CAB71247.1| (AL138598) 2-amino-3-ketobutyrate coenzyme A ligase. [Streptomyces
coelicolor A3(2)]
Length = 397
Score = 292 bits (739), Expect = 6e-78
Identities = 165/385 (42%), Positives = 240/385 (61%), Gaps = 8/385 (2%)
Query: 8 DWIKEELEELKKKGLYVTIRVLQSAQGPWV-VVNGKR---VLNMCSNNYLGLAAHPKIKE 63
D ++ L+E++ GL+ RV+ + Q V V G R VLN C+NNYLGLA HP++
Sbjct: 7 DDLRATLDEIRAAGLHKPERVIGTPQSATVNVTAGGRPGEVLNFCANNYLGLADHPEVVA 66
Query: 64 AAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALL 123
AA A+ +G G +VR I GT E+H ELE +L+ F +E IL+ S ++AN G LL
Sbjct: 67 AAHEALDRWGYGMASVRFICGTQEVHKELEARLSAFLGQEDTILYSSCFDANGGVFETLL 126
Query: 124 RKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGV 183
G + +S+ LNHASIIDG+RLS A ++ Y + DM DL+ +L+ + ++K+IVTDGV
Sbjct: 127 --GPEDAVISDALNHASIIDGIRLSKAKRLRYANRDMADLEAQLKAAGEARRKLIVTDGV 184
Query: 184 FSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLS 243
FSMDG +APL EI +LA++YDA+V VDD+H G +G GRG + + D+VD GTL
Sbjct: 185 FSMDGYVAPLDEICDLADRYDAMVMVDDSHAVGFVGPGGRGTPELHGVMDRVDIITGTLG 244
Query: 244 KAF-GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLW 302
KA G GGYVA E + L+QR+RP+LFS+ + P AA++ +++L+ +DDL +L
Sbjct: 245 KALGGASGGYVAARAEIVALLRQRSRPYLFSNTLAPVIAAASLKVLDLLESADDLRVRLA 304
Query: 303 DNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPL 362
+NT ++ + D G+D+ H I PVM+ D A + L E ++ YP VP
Sbjct: 305 ENTALFRRRMTDEGFDILPGDHAIAPVMIGDATKAGRMAELLLER-GVYVIGFSYPVVPQ 363
Query: 363 GTARIRLEPSAAHTKEDLKLVIDAF 387
ARIR++ SAAH+ +D+ +DAF
Sbjct: 364 DKARIRVQLSAAHSTDDVNRAVDAF 388
>sp|O66875|BIOF_AQUAE 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|7433706|pir||G70355 8-amino-7-oxononanoate synthase
(EC 2.3.1.47) - Aquifex aeolicus
>gi|2983240|gb|AAC06836.1| (AE000699)
8-amino-7-oxononanoate synthase [Aquifex aeolicus]
Length = 373
Score = 284 bits (719), Expect = 1e-75
Identities = 157/386 (40%), Positives = 244/386 (62%), Gaps = 20/386 (5%)
Query: 9 WIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
WI+EEL+ +K+ LY +L+ V + CSN+YLGL HP++ E +IR
Sbjct: 3 WIEEELKRIKEANLYRERILLEG------------VKDFCSNDYLGLRKHPEVVEESIRV 50
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
+ + G+G+GA + ++G + H ELEEKLA+FK E+ +LF SG+ AN+G I AL+ +G+
Sbjct: 51 LKEAGLGSGASQLVSGYTKHHRELEEKLAEFKGTESCVLFGSGFLANVGTIPALVEEGD- 109
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDK-KKKIIVTDGVFSMD 187
+ LS+ELNHASIIDG+RLS A K ++KH D ++L++ L++N+ K ++ +I+TD VFSMD
Sbjct: 110 -LVLSDELNHASIIDGVRLSKAQKRVFKHKDYEELEEFLKKNRKKFRRVLIITDTVFSMD 168
Query: 188 GDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNL-HDKVDFEMGTLSKAF 246
GD+A L + ++ E+YD ++Y+D+AH G + G+G +D+F + H + MGTLSKA
Sbjct: 169 GDVADLKRLTQICEEYDCMLYIDEAHTTGTI---GKGGLDYFGIEHKEYIIVMGTLSKAL 225
Query: 247 GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTH 306
G G +V G + I+YL +AR +FS+++ P A A A+EI++++ L++ L
Sbjct: 226 GSYGAFVCGTKLLIDYLVNKARSLIFSTSLPPSVCAGAKKAIEIIEENPKLIEFLRKKEK 285
Query: 307 FLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTAR 366
+ + L D PI P+M+YDEK L +E +F QAI YPTVP G AR
Sbjct: 286 EILEILEQFSLDYKYYSTPIIPIMVYDEKETVRIKEELLKE-GVFIQAIRYPTVPKGKAR 344
Query: 367 IRLEPSAAHTKEDLKLVIDAFEDLGK 392
+RL S +T++DL+ + +A E + K
Sbjct: 345 LRLTASLNYTRKDLEFLKNALEKVLK 370
>sp|P53556|BIOF_BACSU 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|7433703|pir||F69594 8-amino-7-oxononanoate synthase
(EC 2.3.1.47) bioF - Bacillus subtilis
>gi|1277027|gb|AAB17459.1| (U51868) L-alanine - pimelyl
CoA ligase [Bacillus subtilis]
>gi|2293185|gb|AAC00263.1| (AF008220) KAPA synthase
[Bacillus subtilis] >gi|2635506|emb|CAB15000.1| (Z99119)
8-amino-7-oxononanoate synthase [Bacillus subtilis]
Length = 389
Score = 283 bits (716), Expect = 3e-75
Identities = 156/389 (40%), Positives = 239/389 (61%), Gaps = 6/389 (1%)
Query: 6 KLD-WIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEA 64
K+D W+ E L+ +K+ G++ +R + A P ++G+ SNNYLGLA+ ++ +A
Sbjct: 2 KIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVWSSNNYLGLASDRRLIDA 61
Query: 65 AIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLR 124
A A+ +G G+ R G H +LE+K+A FK EAA+LF SGY AN+G +S+L
Sbjct: 62 AQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAALLFSSGYLANVGVLSSLPE 121
Query: 125 KGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVF 184
K + + LS++LNHAS+IDG RLS A V+Y+H+DM+DL+ KL E + +++ IVTDGVF
Sbjct: 122 K--EDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLENKLNETQRYQRRFIVTDGVF 179
Query: 185 SMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSK 244
SMDG +APL +I+ LA++Y A V VDDAH GVLG G+G ++F + D +GTLSK
Sbjct: 180 SMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQGTSEYFGVCP--DIVIGTLSK 237
Query: 245 AFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDN 304
A G GG+ AG I++L AR F+F +A+ P AAA A I++ S + + L+
Sbjct: 238 AVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAAAHEAFNIIEASREKRQLLFSY 297
Query: 305 THFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGT 364
++ L+++GY + PI PV++ D F+ +L + I+A AI PTV G
Sbjct: 298 ISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFAEKL-QGKGIYAPAIRPPTVAPGE 356
Query: 365 ARIRLEPSAAHTKEDLKLVIDAFEDLGKK 393
+RIR+ ++ H+ D+ ++ F +GK+
Sbjct: 357 SRIRITITSDHSMGDIDHLLQTFHSIGKE 385
>dbj|BAB07626.1| (AP001520) 8-amino-7-oxononanoate synthase [Bacillus halodurans]
Length = 395
Score = 272 bits (687), Expect = 7e-72
Identities = 160/386 (41%), Positives = 237/386 (60%), Gaps = 7/386 (1%)
Query: 8 DW---IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEA 64
DW I+E+L LK +G + + A PW+ R+LN+ SNNYLG+A + E
Sbjct: 4 DWLHAIEEKLTRLKDRGSFRQLVPTSEAALPWLTRENCRLLNLASNNYLGIADSKEFIER 63
Query: 65 AIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLR 124
+ Y +G+ A R I G L+ E E +L K+KK EAA++F SGY AN+G IS+++
Sbjct: 64 TEQLASSYAIGSTASRLIIGNHPLYEEAEYELTKWKKTEAALIFGSGYMANVGIISSIVG 123
Query: 125 KGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVF 184
+G D +F S++LNHASI+DG +LS A + ++H DMD L+ L+++ K+K +IV D +F
Sbjct: 124 RG-DAVF-SDKLNHASIVDGCQLSRADHLRFRHNDMDHLETLLQKSPHKQK-LIVVDALF 180
Query: 185 SMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSK 244
SMDGD A L ++V L E+Y AI+ VD+AH GV G+ G G+V+ L+D+VD +MGT SK
Sbjct: 181 SMDGDHANLHDLVTLKERYGAILMVDEAHSGGVYGATGGGLVEELGLNDRVDIQMGTFSK 240
Query: 245 AFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDN 304
A G GGYVAG + IEYL AR +F++A+ P VA+ +AA++I+Q+ +K+
Sbjct: 241 ALGSYGGYVAGAKPFIEYLLNHARSLIFTTALPPYIVASHLAALQIVQEQPWRREKVQVL 300
Query: 305 THFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGT 364
L+ GL LG+ L ++ I PV++ D S L + I A + PTVP G
Sbjct: 301 GERLRNGLEQLGFSLCGSESYIVPVLIGDNHDLLLVSESL-QAAGIAAIPVRPPTVPRGE 359
Query: 365 ARIRLEPSAAHTKEDLKLVIDAFEDL 390
RIRL +A+HT++D+ I+ F+ L
Sbjct: 360 GRIRLTVTASHTEKDIDWAIEQFQRL 385
>sp|Q58694|BIOF_METJA 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|2127727|pir||A64462 8-amino-7-oxononanoate synthase
(EC 2.3.1.47) - Methanococcus jannaschii
>gi|1591936|gb|AAB99305.1| (U67570)
8-amino-7-oxononanoate synthase (bioF) [Methanococcus
jannaschii]
Length = 372
Score = 271 bits (686), Expect = 9e-72
Identities = 161/383 (42%), Positives = 235/383 (61%), Gaps = 22/383 (5%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAI 69
++ E+E +K GLY +R VL+ SN+YL L+ HP++ EA ++
Sbjct: 6 LRREIEIIKNNGLYRFLRKKDDG-----------VLDFSSNDYLCLSKHPEVIEA-VKEG 53
Query: 70 LDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDG 129
L YG G+ R +G + H LEEK+A+FK+ E +++ SGY N+G ISAL +KG+
Sbjct: 54 LKYGAGSTGSRLTSGNIN-HQRLEEKIAEFKETERTLVYSSGYATNVGVISALCKKGD-- 110
Query: 130 IFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKI-IVTDGVFSMDG 188
+ LS++LNHASIIDG +LS A +IY H D++ L +EEN K + IVTDGVFSMDG
Sbjct: 111 LILSDKLNHASIIDGCKLSKADVLIYNHCDVEHLTNLIEENWGKYNNLFIVTDGVFSMDG 170
Query: 189 DLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDF-EMGTLSKAFG 247
D+APL ++ ++A++++AI+ +DDAHG GVLG GRG + HFNL + ++GTLSKA G
Sbjct: 171 DIAPLRDLKKIADEFNAILIIDDAHGTGVLGD-GRGTLKHFNLKPSDNIVQIGTLSKAIG 229
Query: 248 VIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHF 307
+GG+V G EE +EYL +R F+FS+A+ P V I A EI++K+ D+VKKL N
Sbjct: 230 GLGGFVCGIEEVVEYLINTSRSFIFSTALPPHVVEGCIKAFEIIEKT-DIVKKLQKNIKI 288
Query: 308 LQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARI 367
K + + + PI P ++ EK E + L + NIF I YPTVP G RI
Sbjct: 289 ANKVFKKYEFIKEDNLTPIYP-FIFKEK-TMEIAEHLIKN-NIFCVGIRYPTVPKGLERI 345
Query: 368 RLEPSAAHTKEDLKLVIDAFEDL 390
R+ + H KED +L+ + +++
Sbjct: 346 RVSINVGHEKEDFELLCERIKEV 368
>pir||S75730 8-amino-7-oxononanoate synthase (EC 2.3.1.47) - Synechocystis sp.
(strain PCC 6803) >gi|1673311|dbj|BAA10465.1| (D64003)
7-keto-8-aminopelargonic acid synthetase [Synechocystis
sp.]
Length = 437
Score = 270 bits (684), Expect = 2e-71
Identities = 146/385 (37%), Positives = 244/385 (62%), Gaps = 11/385 (2%)
Query: 9 WIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
W+ + LE +++ + +++ GP + + G+R++N SN+YLGLA+HP +K AAI+A
Sbjct: 54 WLDDALETIQRAHWHRHPQIITQGPGPEIKLEGQRLVNFASNDYLGLASHPHLKTAAIKA 113
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
I ++G G+ R ++G +LH +LE+ +A++K EAA++F SGY ANLG I+AL+ G+
Sbjct: 114 IAEWGTGSTGSRLLSGHRQLHQDLEQAIARWKGTEAALVFSSGYLANLGTITALV--GKR 171
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKK-IIVTDGVFSMD 187
+ L++E NH+S+ G +LSGA + Y H + L L +++D ++ +I++DGVFSMD
Sbjct: 172 DLILADEYNHSSLKRGAQLSGAKVINYDHGCPEVLTDLLMKHRDNHRRCLILSDGVFSMD 231
Query: 188 GDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFG 247
GDL PLP++V +AE++ +++ VDDAHG G +G G G +HF L ++GTLSKA G
Sbjct: 232 GDLCPLPQLVAIAEEFQSMLLVDDAHGTGTMGKMGTGCREHFQLPVGDWIQVGTLSKALG 291
Query: 248 VIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHF 307
+GGYVAG I++L+ RA +++++ ++P D AAA+AA++++Q+ + + +L N +
Sbjct: 292 SLGGYVAGSASLIDFLRNRAATWIYTTGLSPADTAAALAAIQLIQREPERIVQLQLNVDY 351
Query: 308 LQKGLRDLGYDLGNTKHPITPVMLY----DEKLAQEFSRRLYEEYNIFAQAIVYPTVPLG 363
L GL L L + PI +L+ + +A E ++ L E+ IFA AI PTVP
Sbjct: 352 LATGLESL-TKLNFRRSPINSPILWVGAANPAMALEMAKHLREQ-GIFAPAIRPPTVP-- 407
Query: 364 TARIRLEPSAAHTKEDLKLVIDAFE 388
+RIR A H+ + +++ +
Sbjct: 408 HSRIRFSVMATHSPGHIDQLLEVLD 432
>dbj|BAA35068.1| (AB015491) 5-aminolevulinate synthase [Rhodopseudomonas palustris]
Length = 403
Score = 257 bits (649), Expect = 2e-67
Identities = 143/397 (36%), Positives = 221/397 (55%), Gaps = 8/397 (2%)
Query: 9 WIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKR------VLNMCSNNYLGLAAHPKIK 62
+ K ++E L ++G Y L+ G + R V CSN+YLG+ HP +
Sbjct: 6 YFKRQIEGLHREGRYRVFADLERHAGSFPRATHHRPEGTSEVTVWCSNDYLGMGQHPAVL 65
Query: 63 EAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISAL 122
A A+ G GAG R IAGT HV LE++LA +EA +LF SGY +N +S L
Sbjct: 66 SAMHEALDTCGAGAGGTRNIAGTNHYHVLLEQELAALHGKEAGLLFASGYVSNWATLSTL 125
Query: 123 LRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDG 182
+ + LS+ELNHAS+I+G+R S + I+ H D DL++KL + K++ +
Sbjct: 126 ASRMPGCVILSDELNHASMIEGIRHSRSETRIFAHNDPRDLERKLADLDPHAPKLVAFES 185
Query: 183 VFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTL 242
V+SMDGD+AP+ EI ++A+ ++A+ Y+D HG G+ G +G GI D L ++ GTL
Sbjct: 186 VYSMDGDIAPIAEICDVADAHNAMTYLDKVHGVGLYGPNGGGIADREGLSHRLTVIEGTL 245
Query: 243 SKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLW 302
+KAFG++GGY+ G ++++ A F+FS+++ P A A+A+V ++ S +
Sbjct: 246 AKAFGIVGGYITGSAALCDFVRSFASGFIFSTSLPPAVAAGALASVRHIRSSSAERDRHQ 305
Query: 303 DNTHFLQKGLRDLGY-DLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVP 361
D L+ L +G + N H I PVM+ D L ++ S L Y I+ Q I YPTVP
Sbjct: 306 DRVARLRMRLDQVGVAHMPNPSH-IVPVMVGDAVLCKQISDELINRYGIYVQPINYPTVP 364
Query: 362 LGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFLK 398
GT R+R+ PS HT D++ ++ A ++ + G K
Sbjct: 365 RGTERLRITPSPQHTDADIEHLVQALSEIWARVGLAK 401
>sp|P26505|HEM1_AGRRD 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINOLEVULINATE SYNTHASE)
(DELTA-ALA SYNTHETASE) >gi|95069|pir||S15996
5-aminolevulinate synthase (EC 2.3.1.37) - Agrobacterium
radiobacter >gi|227844|prf||1712312A delta
aminolevulinic acid synthetase [Agrobacterium
radiobacter]
Length = 405
Score = 246 bits (621), Expect = 4e-64
Identities = 140/385 (36%), Positives = 216/385 (55%), Gaps = 7/385 (1%)
Query: 13 ELEELKKKGLYVTIRVLQSAQGPW-----VVVNGKR--VLNMCSNNYLGLAAHPKIKEAA 65
EL+ L +G Y ++ QG + NG+R V CSN+YLG+ +PK+ EA
Sbjct: 10 ELQSLHSEGRYRVFADIERQQGNFPRATRYNANGQRKDVTVWCSNDYLGMGQNPKVIEAM 69
Query: 66 IRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRK 125
AI G GAG R I+GT HV LE++LA +E+A++F SGY +N + L +K
Sbjct: 70 KAAIDHCGAGAGGTRNISGTNHYHVLLEQELADLHGKESALIFTSGYVSNWATLGTLGQK 129
Query: 126 GEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFS 185
I S+ LNHAS+I+G+R +VI+KH D++DL+ KL+ K+I + V+S
Sbjct: 130 IPGLIIFSDALNHASMIEGIRYGRCERVIWKHNDLEDLEAKLKAADPNAPKLIAFESVYS 189
Query: 186 MDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKA 245
MDGD+AP+ EI +LA++Y A+ Y+D+ H G+ G G GI + L D++ GTL KA
Sbjct: 190 MDGDIAPIKEICDLADRYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLTIIEGTLGKA 249
Query: 246 FGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNT 305
FGV+GGY+ G ++++ A F+F++A+ P A AIA+++ L+ S + D
Sbjct: 250 FGVMGGYITGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLKASPFERARHQDRV 309
Query: 306 HFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTA 365
L+ L G + I PVM+ D + S L + + ++ Q I YPTVP T
Sbjct: 310 RKLRGLLDARGIPHMDNPSHIVPVMVGDAAKCKWISDILLDSHGVYVQPINYPTVPRKTE 369
Query: 366 RIRLEPSAAHTKEDLKLVIDAFEDL 390
R+R+ P+ H+ D++ ++ A L
Sbjct: 370 RLRITPTPLHSDADIEHLVGALHQL 394
>pir||G83582 8-amino-7-oxononanoate synthase PA0501 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9946365|gb|AAG03890.1|AE004487_4 (AE004487)
8-amino-7-oxononanoate synthase [Pseudomonas aeruginosa]
Length = 401
Score = 245 bits (620), Expect = 5e-64
Identities = 152/384 (39%), Positives = 220/384 (56%), Gaps = 18/384 (4%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAI 69
+ L + + LY +L+SAQGP VVV+G+ +L CSN+YLGLA HP++ A
Sbjct: 5 LASRLASRRAEDLYRQRPLLESAQGPDVVVDGQPLLAFCSNDYLGLANHPEVIAALRAGA 64
Query: 70 LDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDG 129
+GVG GA + G H ELE LA+F R A+LF +GY ANLGA++AL+ KG+
Sbjct: 65 ERWGVGGGASHLVVGHSGPHHELELALAEFTGRPRALLFSTGYMANLGAVAALVGKGD-- 122
Query: 130 IFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGD 189
L + LNHAS++D LSGA Y H D L +L+ K + ++VTDGVFSMDG+
Sbjct: 123 TVLEDRLNHASLLDAGLLSGARFSRYLHNDPASLAARLD--KAEGNTLVVTDGVFSMDGN 180
Query: 190 LAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNL-HDKVDFEMGTLSKAFGV 248
LA LP + +A+ A + VDDAHG G LG+ G GIV+HF L ++V +GTL K FG
Sbjct: 181 LADLPALAAVAQARGAWLMVDDAHGFGPLGASGGGIVEHFGLGQEQVPVLIGTLGKGFGT 240
Query: 249 IGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHF- 307
G +VAG EE IE L Q ARP++++++ P A + ++E+L++ W H
Sbjct: 241 AGAFVAGSEELIETLIQYARPYIYTTSQPPAVACATLKSLELLRRES------WRRQHLA 294
Query: 308 -----LQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPL 362
+ G LG L ++ PI P+++ + A + L I AI PTVP
Sbjct: 295 ALIARFRHGAEALGLTLMDSFTPIQPILVGGSRQAVALAGML-RARGIMVGAIRPPTVPA 353
Query: 363 GTARIRLEPSAAHTKEDLKLVIDA 386
+AR+R+ SAAH++ + +++A
Sbjct: 354 NSARLRVTLSAAHSEAQVDRLLEA 377
>sp|Q9ZCB8|HEM1_RICPR 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINOLEVULINATE SYNTHASE)
(DELTA-ALA SYNTHETASE) >gi|7433712|pir||A71646
5-aminolevulinate synthase (EC 2.3.1.37) RP841 -
Rickettsia prowazekii >gi|3861366|emb|CAA15265.1|
(AJ235273) 5-AMINOLEVULINIC ACID SYNTHASE (hemA)
[Rickettsia prowazekii]
Length = 414
Score = 241 bits (609), Expect = 1e-62
Identities = 128/367 (34%), Positives = 216/367 (57%), Gaps = 2/367 (0%)
Query: 12 EELEELKKKGLYVTIRVL--QSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAI 69
+ ++++K +G Y + L Q+ P+ K+++ C N+YLG++ H K+ +A+I A+
Sbjct: 10 KHIDKIKSEGRYREFKSLKRQADNFPFAEYEDKQIVMWCINDYLGMSKHVKVMQASIDAL 69
Query: 70 LDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDG 129
L YGVG+G R I G +ELE++LA +E A++F SG+ AN +++L + D
Sbjct: 70 LKYGVGSGGTRNIGGNNISILELEKELADLHSKETALVFTSGFVANDTTLASLAKIIPDI 129
Query: 130 IFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGD 189
+F S+ELNHASII G++ S A K +Y+HLD+ L+K L+ K KIIV + +SMDG
Sbjct: 130 VFFSDELNHASIIAGIKSSRAEKYVYRHLDVQHLEKLLQSVDINKPKIIVFESAYSMDGF 189
Query: 190 LAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVI 249
+P+ +I+ LA++Y+A+ ++D+ H G+ G G GI + + +++D GTL+KA+G I
Sbjct: 190 FSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGISELLDCSNQIDIIQGTLAKAYGTI 249
Query: 250 GGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQ 309
GGY+ I+ ++ A F+F++++ P AA ++ L++S++ K + L+
Sbjct: 250 GGYITSNYNLIDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKESNEERIKHQEVVTKLK 309
Query: 310 KGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRL 369
+ I P+++ D A + S L EY I+ Q I +PTVP GT R+R+
Sbjct: 310 NSFEHFNIPYLKNESHIIPIIIGDPIKATKVSNMLLNEYGIYVQHINFPTVPRGTERLRI 369
Query: 370 EPSAAHT 376
P+ AHT
Sbjct: 370 IPTPAHT 376
>pir||T38542 probable 5-aminolevulinate synthase (EC 2.3.1.37) SPAC2F3.09
[similarity] - fission yeast (Schizosaccharomyces pombe)
>gi|2408063|emb|CAB16265.1| (Z99165) probable
5-aminolevulinic acid synthase [Schizosaccharomyces
pombe]
Length = 558
Score = 236 bits (596), Expect = 3e-61
Identities = 132/353 (37%), Positives = 213/353 (59%), Gaps = 2/353 (0%)
Query: 43 RVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKR 102
RV CSN+YL + H KI+EA + I YG GAG R IAG + V LE+ LA ++
Sbjct: 175 RVEVWCSNDYLNMGGHKKIREAMHQCIETYGGGAGGTRNIAGHNQHAVRLEKSLADLHQK 234
Query: 103 EAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDD 162
AA++F S Y AN +S L RK + IFLS+E+NHAS+I+G+R S K+I+KH D+ D
Sbjct: 235 PAALVFGSCYVANDATLSTLGRKLPNCIFLSDEMNHASMINGIRNSRCEKIIFKHNDLVD 294
Query: 163 LKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHG 222
L+ KL + KII + V+SM G++AP+ EI +LA++Y AI ++D+ H G+ G G
Sbjct: 295 LEAKLASLPLNRPKIIAFESVYSMSGNVAPISEICDLAKKYGAITFLDEVHAVGMYGPRG 354
Query: 223 RGIVDHF-NLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDV 281
G+ + L +VD GTL+K++G +GGY+A ++ ++ A F+F++++ P +
Sbjct: 355 AGVAEETPGLLSRVDIITGTLAKSYGCVGGYIAASSTLVDMIRSLAPGFIFTTSLPPHVM 414
Query: 282 AAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFS 341
A+ AVE L+ S+ ++ +++ L ++G + + I P M+ D LA+ S
Sbjct: 415 VGALTAVEHLKVSNVEREQQRSAVRRVKQSLSEIGIPVLSNDTHIVPAMVGDAHLAKLAS 474
Query: 342 RRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAH-TKEDLKLVIDAFEDLGKK 393
L ++NI+ Q+I +PTV +GT R+R+ P+ AH T+ ++ + +A D+ K
Sbjct: 475 DSLLHDHNIYVQSINFPTVSVGTERLRITPTPAHNTEHYVQSLTNAMNDVWSK 527
>sp|Q06965|HEM0_RHOSH 5-AMINOLEVULINIC ACID SYNTHASE 2 (DELTA-AMINOLEVULINATE SYNTHASE)
(DELTA-ALA SYNTHETASE) >gi|541302|pir||A49845
5-aminolevulinate synthase (EC 2.3.1.37) HemT -
Rhodobacter sphaeroides >gi|151939|gb|AAA26124.1|
(L07489) 5-aminolevulinic acid synthase isozyme
[Rhodobacter sphaeroides]
Length = 407
Score = 235 bits (594), Expect = 6e-61
Identities = 135/390 (34%), Positives = 220/390 (55%), Gaps = 7/390 (1%)
Query: 14 LEELKKKGLYVTIRVLQSAQG--PWVVVNG-----KRVLNMCSNNYLGLAAHPKIKEAAI 66
+++++ G Y T L+ G P + +G +RV CSN+YLG+ + ++ A
Sbjct: 11 IDDMRLDGRYRTFAELERIAGEFPTALWHGPDGQARRVTVWCSNDYLGMGQNAEVLAAMH 70
Query: 67 RAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKG 126
R+I G G G R I+GT HV LE +LA +E+A++F SG+ +NL A+ L +
Sbjct: 71 RSIDLSGAGTGGTRNISGTNRQHVALEAELADLHGKESALIFTSGWISNLAALGTLGKIL 130
Query: 127 EDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSM 186
+ S+ LNH S+I+G+R SGA + I+ H D L + L + KI+ + V+SM
Sbjct: 131 PECAIFSDALNHNSMIEGIRRSGAERFIFHHNDPVHLDRLLSSVDPARPKIVAFESVYSM 190
Query: 187 DGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF 246
DGD+AP+ EI ++AE++ A+ Y+D+ H G+ G G GI D L D+V GTL+KAF
Sbjct: 191 DGDIAPIAEICDVAERHGALTYLDEVHAVGLYGPRGGGISDRDGLADRVTIIEGTLAKAF 250
Query: 247 GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTH 306
GV+GGYV+GP ++ ++ + F+F++++ P A A+AAV ++ D ++ +N
Sbjct: 251 GVMGGYVSGPSLLMDVIRSMSDSFIFTTSICPHLAAGALAAVRHVKAHPDERRRQAENAV 310
Query: 307 FLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTAR 366
L+ L+ G + +T I PVM+ + L + S L + I+ Q I YPTV G R
Sbjct: 311 RLKVLLQKAGLPVLDTPSHILPVMVGEAHLCRSISEALLARHAIYVQPINYPTVARGQER 370
Query: 367 IRLEPSAAHTKEDLKLVIDAFEDLGKKTGF 396
RL P+ HT ++ +++A +G+ G+
Sbjct: 371 FRLTPTPFHTTSHMEALVEALLAVGRDLGW 400
>sp|P08262|HEM1_BRAJA 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINOLEVULINATE SYNTHASE)
(DELTA-ALA SYNTHETASE) >gi|66534|pir||SYZJAL
5-aminolevulinate synthase (EC 2.3.1.37) -
Bradyrhizobium japonicum >gi|152097|gb|AAA26216.1|
(M16751) 5-aminolevulinic acid synthase (ALAS)
[Bradyrhizobium japonicum]
Length = 409
Score = 235 bits (593), Expect = 7e-61
Identities = 128/341 (37%), Positives = 202/341 (58%), Gaps = 1/341 (0%)
Query: 36 WVVVNGKR-VLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEE 94
W GKR V+ CSN+YLG+ HPK+ A + G GAG R IAGT V+LE
Sbjct: 38 WHSPKGKRDVVIWCSNDYLGMGQHPKVVGAMVETATRVGTGAGGTRNIAGTHHPLVQLEA 97
Query: 95 KLAKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVI 154
+LA +EAA+LF SGY +N I+ + + + + LS+ELNH S+I+G+R SG + +
Sbjct: 98 ELADLHGKEAALLFTSGYVSNQTGIATIAKLIPNCLILSDELNHNSMIEGIRQSGCERQV 157
Query: 155 YKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHG 214
++H D+ DL+ L+ + K+I + ++SMDGD+APL +I +LAE+Y+A+ YVD+ H
Sbjct: 158 FRHNDLADLEALLKAAGANRPKLIACESLYSMDGDVAPLAKICDLAEKYNAMTYVDEVHA 217
Query: 215 EGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSS 274
G+ G G GI + + ++D GTL+KAFG +GGY+A I+ ++ A F+F++
Sbjct: 218 VGMYGPRGGGIAERDGVMHRIDILEGTLAKAFGCLGGYIAANGRIIDAVRSYAPGFIFTT 277
Query: 275 AMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDE 334
A+ P +AA AA++ L+ S ++ D ++ L G + ++ I P+ + D
Sbjct: 278 ALPPAICSAATAAIKHLKTSSWERERHQDRAARVKAILNAAGLPVMSSDTHIVPLFIGDA 337
Query: 335 KLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAH 375
+ ++ S L EE+ I+ Q I YPTV G+ R+R+ PS H
Sbjct: 338 EKCKQASDLLLEEHGIYIQPINYPTVAKGSERLRITPSPYH 378
>gb|AAF44353.1|AF195767_1 (AF195767) 2-amino-3-ketobutyrate coenzyme A ligase [Bos taurus]
Length = 262
Score = 234 bits (591), Expect = 1e-60
Identities = 121/259 (46%), Positives = 173/259 (66%), Gaps = 5/259 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKR--VLNMCSNNYLGLAAHPKIKEAAIR 67
++EELE ++ G + + RV+ S QGP + V+G ++N C+NNYLGL++HP++ +A +R
Sbjct: 6 LEEELESIRGAGTWKSERVITSRQGPHIHVDGAPGGIINFCANNYLGLSSHPEVIQAGLR 65
Query: 68 AILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGE 127
+ ++G G +VR I GT +H +LE K+A+F +RE AIL+ S ++AN G ALL E
Sbjct: 66 TLKEFGAGLSSVRFICGTQSIHKDLEAKIARFHQREDAILYPSCFDANTGLFEALLTS-E 124
Query: 128 DGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMD 187
D + LS+ELNHASIIDG+RL A K Y+HLDM DL+ KL+E + + +++ TDG FSMD
Sbjct: 125 DAV-LSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMD 183
Query: 188 GDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF- 246
GD+APL EI LA QY A+V+VD++H G LG+ GRG + + D+V TL KA
Sbjct: 184 GDIAPLQEICRLASQYGALVFVDESHATGFLGATGRGTDELLGVMDQVTIINSTLGKALG 243
Query: 247 GVIGGYVAGPEEAIEYLKQ 265
G GGY GP + L+Q
Sbjct: 244 GASGGYTTGPGALVSLLRQ 262
>sp|P78698|HEM1_KLULA 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRIAL PRECURSOR
(DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA SYNTHETASE)
>gi|1854516|emb|CAA63497.1| (X92944) 5-aminolevulinate
synthase [Kluyveromyces lactis]
Length = 570
Score = 234 bits (590), Expect = 2e-60
Identities = 128/364 (35%), Positives = 211/364 (57%), Gaps = 16/364 (4%)
Query: 43 RVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKR 102
+V CSN+YL L+ + ++ E + + YG GAG R IAG + ++LE +LA K+
Sbjct: 142 KVTVWCSNDYLALSKNQEVIEVMKKTLDKYGAGAGGTRNIAGHNKHALQLEAELATLHKK 201
Query: 103 EAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDD 162
E A++F S + AN IS L +K +D + S+ELNHAS+I G++ + K I+KH ++D
Sbjct: 202 EGALVFSSCFVANDAVISLLGQKIKDLVIFSDELNHASMIVGIKHASTKKHIFKHNNLDQ 261
Query: 163 LKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHG 222
L++ L K+I + V+SM G +A + +I +LAE+Y A+ ++D+ H G+ G HG
Sbjct: 262 LEELLAMYPKSTPKLIAFESVYSMSGSVADIDKICDLAEKYGALTFLDEVHAVGLYGPHG 321
Query: 223 RGIVDHFN----------------LHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQR 266
G+ +H N + D+VD GTL K+FG +GGYVAG + I++++
Sbjct: 322 AGVAEHCNFDRHRKAGIASPEFRTVMDRVDMITGTLGKSFGTVGGYVAGSLQLIDWVRSY 381
Query: 267 ARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPI 326
A F+F++ + P +A A A+ + DL + +T +++ GL DLG + I
Sbjct: 382 APGFIFTTTLPPAVMAGAAEAIRYQRSHLDLRQDQQRHTTYVKDGLADLGIPVMPNPSHI 441
Query: 327 TPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
PV++ + LA++ S L +++ I+ QAI +PTV GT R+R+ PS HT + +++DA
Sbjct: 442 VPVLVGNPHLAKQASDILMDKHRIYVQAINFPTVARGTERLRITPSPGHTNDLSDILMDA 501
Query: 387 FEDL 390
ED+
Sbjct: 502 LEDV 505
>sp|P43090|HEM0_OPSTA 5-AMINOLEVULINIC ACID SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL
PRECURSOR (DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA
SYNTHETASE) (ALAS-E) >gi|213491|gb|AAA60729.1| (L02632)
5-aminolevulinate synthase [Opsanus tau]
Length = 582
Score = 233 bits (588), Expect = 3e-60
Identities = 123/359 (34%), Positives = 211/359 (58%), Gaps = 2/359 (0%)
Query: 41 GKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
G +V CSN+YLG++ HP++ EA + +G GAG R I+GT + HV LE++LA
Sbjct: 183 GSQVSVWCSNDYLGMSRHPRVLEAIREVLERHGAGAGGTRNISGTSKYHVTLEKELAHLH 242
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
+++AA++F S + AN + L + S+ NHAS+I G+R SGA + I++H D
Sbjct: 243 QKDAALVFSSCFVANDSTLFTLAKMLPGCHIYSDAGNHASMIQGIRNSGAKRFIFRHNDS 302
Query: 161 DDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGS 220
L++ L+++ K KI+ + V SMDG + PL E+ ++A ++ A+ +VD+ H G+ G+
Sbjct: 303 RHLEELLQQSDPKTPKIVAFETVHSMDGAICPLEELCDVAHRHGALTFVDEVHAVGLYGA 362
Query: 221 HGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPD 280
HG G+ + N+ K+D GTL KAFG +GGYVA ++ ++ A F+F++++ P
Sbjct: 363 HGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYVASSAALVDTVRSFAAGFIFTTSLPPMI 422
Query: 281 VAAAIAAVEILQKSD-DLVKKLWD-NTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQ 338
+A A+ +V +L+ + L+++ N ++++ L D G + N I P+ + + +L
Sbjct: 423 LAGALESVRVLKSPEGQLLRRAHQRNVKYMRQLLMDKGLPVVNCPSHIIPIRVGNAELNT 482
Query: 339 EFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTGFL 397
+ L E++NI+ QAI YPTVP G +RL PS H ++ +D ++ ++ G L
Sbjct: 483 KVCDSLLEKHNIYVQAINYPTVPRGQELLRLAPSPHHHPAMMEYFVDKLVEVWQEAGLL 541
>gi|4758668 serine palmitoyltransferase, long chain base subunit 2; serine
palmitoyltransferase, subunit II [Homo sapiens]
>gi|11434916|ref|XP_007410.1| serine
palmitoyltransferase, long chain base subunit 2 [Homo
sapiens] >gi|6685580|sp|O15270|LCB2_HUMAN SERINE
PALMITOYLTRANSFERASE 2 (LONG CHAIN BASE BIOSYNTHESIS
PROTEIN 2) (LCB 2) (SERINE-PALMITOYL-COA TRANSFERASE 2)
(SPT 2) (KIAA0526) >gi|2564249|emb|CAA69942.1| (Y08686)
serine palmitoyltransferase, subunit II [Homo sapiens]
>gi|3043576|dbj|BAA25452.1| (AB011098) KIAA0526 protein
[Homo sapiens] >gi|4186182|gb|AAD09621.1| (AF111168)
serine palmitoyl transferase, subunit II [Homo sapiens]
Length = 562
Score = 233 bits (588), Expect = 3e-60
Identities = 133/368 (36%), Positives = 218/368 (59%), Gaps = 21/368 (5%)
Query: 42 KRVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
K V+NM S NYLG A + +EAA + + +YG G + R G ++ H ELEE +A+F
Sbjct: 168 KGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFL 227
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
EAA+ + G+ N I AL+ KG + LS+ELNHAS++ G RLSGA I+KH +M
Sbjct: 228 GVEAAMAYGMGFATNSMNIPALVGKG--CLILSDELNHASLVLGARLSGATIRIFKHNNM 285
Query: 161 DDLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
L+K L++ + KK +I+ +G++SM+G + LPE++ L ++Y A +Y+D+
Sbjct: 286 QSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDE 345
Query: 212 AHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G LG GRG+V++F L + VD MGT +K+FG GGY+ G +E I+YL+ +
Sbjct: 346 AHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSA 405
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYDL-GNTK 323
+++++++PP V I +++ + D + V++L +NT + ++ L+++G+ + GN
Sbjct: 406 VYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNED 465
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLV 383
P+ P+MLY F R + + NI + +P P+ +R R SAAHTKE L
Sbjct: 466 SPVVPLMLYMPAKIGAFGREMLKR-NIGVVVVGFPATPIIESRARFCLSAAHTKEILDTA 524
Query: 384 IDAFEDLG 391
+ +++G
Sbjct: 525 LKEIDEVG 532
>pir||JC5180 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 chain - mouse
Length = 560
Score = 233 bits (587), Expect = 4e-60
Identities = 132/368 (35%), Positives = 217/368 (58%), Gaps = 21/368 (5%)
Query: 42 KRVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
K V+NM S NYLG A + +EAA + +YG G + R G ++ H ELE+ +A+F
Sbjct: 166 KGVINMGSYNYLGFARNTGSCQEAAAEVLKEYGAGVCSTRQEIGNLDKHEELEKLVARFL 225
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
EAA+ + G+ N I AL+ KG + LS+ELNHAS++ G RLSGA I+KH +M
Sbjct: 226 GVEAAMTYGMGFATNSMNIPALVGKG--CLILSDELNHASLVLGARLSGATIRIFKHNNM 283
Query: 161 DDLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
L+K L++ + KK +I+ +G++SM+G + LPE++ L ++Y A +Y+D+
Sbjct: 284 QSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDE 343
Query: 212 AHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G LG GRG+VD+F L + VD MGT +K+FG GGY+ G +E I+YL+ +
Sbjct: 344 AHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSA 403
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYDL-GNTK 323
+++++M+PP + I +++ + D + +++L +NT + ++ L+++G+ + GN
Sbjct: 404 VYATSMSPPVMEQIITSMKCIMGQDGTSLGKECIQQLAENTRYFRRRLKEMGFIIYGNED 463
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLV 383
P+ P+MLY F R + + NI + +P P+ +R R SAAHTKE L
Sbjct: 464 SPVVPLMLYMPAKIGAFGREMLKR-NIGVVVVGFPATPIIESRARFCLSAAHTKEILDTA 522
Query: 384 IDAFEDLG 391
+ +++G
Sbjct: 523 LKEIDEVG 530
>gi|6755656 serine palmitoyltransferase, long chain base subunit 2; serine
palmitoyltransferase, long chain base subunit 2# [Mus
musculus] >gi|6685600|sp|P97363|LCB2_MOUSE SERINE
PALMITOYLTRANSFERASE 2 (LONG CHAIN BASE BIOSYNTHESIS
PROTEIN 2) (LCB 2) (SERINE-PALMITOYL-COA TRANSFERASE 2)
(SPT 2) >gi|1838984|emb|CAA64898.1| (X95642) serine
C-palmitoyltransferase [Mus musculus]
>gi|2267217|gb|AAC53310.1| (U27455) serine
palmitoyltransferase LCB2 subunit [Mus musculus]
Length = 560
Score = 233 bits (587), Expect = 4e-60
Identities = 132/368 (35%), Positives = 217/368 (58%), Gaps = 21/368 (5%)
Query: 42 KRVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
K V+NM S NYLG A + +EAA + +YG G + R G ++ H ELE+ +A+F
Sbjct: 166 KGVINMGSYNYLGFARNTGSCQEAAAEVLKEYGAGVCSTRQEIGNLDKHEELEKLVARFL 225
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
EAA+ + G+ N I AL+ KG + LS+ELNHAS++ G RLSGA I+KH +M
Sbjct: 226 GVEAAMTYGMGFATNSMNIPALVGKG--CLILSDELNHASLVLGARLSGATIRIFKHNNM 283
Query: 161 DDLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
L+K L++ + KK +I+ +G++SM+G + LPE++ L ++Y A +Y+D+
Sbjct: 284 QSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDE 343
Query: 212 AHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G LG GRG+VD+F L + VD MGT +K+FG GGY+ G +E I+YL+ +
Sbjct: 344 AHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSA 403
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYDL-GNTK 323
+++++M+PP + I +++ + D + +++L +NT + ++ L+++G+ + GN
Sbjct: 404 VYATSMSPPVMEQIITSMKCIMGQDGTSLGKECIQQLAENTRYFRRRLKEMGFIIYGNED 463
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLV 383
P+ P+MLY F R + + NI + +P P+ +R R SAAHTKE L
Sbjct: 464 SPVVPLMLYMPAKIGAFGREMLKR-NIGVVVVGFPATPIIESRARFCLSAAHTKEILDTA 522
Query: 384 IDAFEDLG 391
+ +++G
Sbjct: 523 LKEIDEVG 530
>gb|AAD38391.1|AF152374_1 (AF152374) 5-aminolevulinic acid synthase [Aspergillus oryzae]
Length = 636
Score = 232 bits (586), Expect = 5e-60
Identities = 127/374 (33%), Positives = 214/374 (56%), Gaps = 22/374 (5%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
+RV CSN+YLG+ +P++ + + YG GAG R I+G + V LE LAK
Sbjct: 190 ERVTVWCSNDYLGMGRNPEVLATMHKTLDTYGAGAGGTRNISGHNQHAVSLENTLAKLHG 249
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+EAA++F S + AN ++ L K D + LS+ LNHAS+I G+R SGA K+++KH D+
Sbjct: 250 KEAALVFSSCFVANDATLATLGSKLPDCVILSDSLNHASMIQGIRHSGAKKMVFKHNDLV 309
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
DL+ KL KII + V+SM G +AP+ +I +LA++Y AI ++D+ H G+ G H
Sbjct: 310 DLEAKLAALPLHVPKIIAFESVYSMCGSIAPIEKICDLADKYGAITFLDEVHAVGMYGPH 369
Query: 222 GRGIVDHFN------------------LHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYL 263
G G+ +H + + D++D GTL KA+G +GGY+AG ++ +
Sbjct: 370 GAGVAEHLDYDIYASQDTVNPRSTKGTVMDRIDIITGTLGKAYGCVGGYIAGSAAMVDTI 429
Query: 264 KQRARPFLFSSAMNPPDVAAAIAAV--EILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGN 321
+ A F+F++++ P +A A A+ + + D ++++L +T ++ ++L +
Sbjct: 430 RSLAPGFIFTTSLPPATMAGADTAIQYQARHQGDRVLQQL--HTRAVKAAFKELDIPVIP 487
Query: 322 TKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLK 381
I P+++ D ++A++ S +L EE+ I+ QAI YPTVP G R+R+ P+ H KE
Sbjct: 488 NPSHIIPLLVGDAEVAKKASDKLLEEHGIYVQAINYPTVPRGEERLRITPTPGHIKEHRD 547
Query: 382 LVIDAFEDLGKKTG 395
++ A + + + G
Sbjct: 548 HLVQAVQTVWNELG 561
>sp|P38092|HEM1_EMENI 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRIAL PRECURSOR
(DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA SYNTHETASE)
>gi|418756|pir||S31846 5-aminolevulinate synthase (EC
2.3.1.37) precursor, mitochondrial - Emericella nidulans
>gi|2361|emb|CAA45508.1| (X64170) 5-aminolevulinic acid
synthase [Emericella nidulans]
Length = 648
Score = 232 bits (585), Expect = 6e-60
Identities = 129/376 (34%), Positives = 215/376 (56%), Gaps = 26/376 (6%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
++V CSN+YLG+ +P++ + + YG GAG R I+G + V LE LAK
Sbjct: 192 EKVTVWCSNDYLGMGRNPEVLATMHKTLDTYGAGAGGTRNISGHNQHAVSLENTLAKLHG 251
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+EAA++F S + AN ++ L K D + LS+ LNHAS+I G+R SG K+++KH D+
Sbjct: 252 KEAALVFSSCFVANDATLATLGSKMPDCVILSDSLNHASMIQGIRHSGRKKMVFKHNDLV 311
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
DL+ KL KII + V+SM G +AP+ I +LA++Y AI ++D+ H G+ G H
Sbjct: 312 DLETKLASLPLHVPKIIAFESVYSMCGSIAPIEAICDLADKYGAITFLDEVHAVGMYGPH 371
Query: 222 GRGIVDHFNLH------------------DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYL 263
G G+ +H + D+++ GTL KA+G +GGY+AG ++ +
Sbjct: 372 GAGVAEHLDYEIYASQDTANPLSTKGTVMDRINIITGTLGKAYGCVGGYIAGSAALVDTI 431
Query: 264 KQRARPFLFSSAMNPPDVAAAIAAV--EILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGN 321
+ A F+F++++ P +A A A+ + + D ++++L +T +++ +DL +
Sbjct: 432 RSLAPGFIFTTSLPPATMAGADTAIRYQARHQQDRILQQL--HTRAVKQSFKDLDIPVIP 489
Query: 322 TKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLK 381
I P+++ D +LA++ S +L EE+ I+ QAI YPTVP G R+R+ P+ HT+E
Sbjct: 490 NPSHIVPLLVGDAELAKQASDKLLEEHGIYVQAINYPTVPRGEERLRITPTPGHTQELRD 549
Query: 382 LVIDA----FEDLGKK 393
+++A + DLG K
Sbjct: 550 HLVEAVNTVWNDLGIK 565
>gb|AAC37294.1| (L46348) delta-aminolevulinic acid synthetase [Plasmodium
falciparum]
Length = 630
Score = 232 bits (585), Expect = 6e-60
Identities = 123/360 (34%), Positives = 218/360 (60%), Gaps = 6/360 (1%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
V+ ++ + CSN+YL L+ + KI E I + G +G R I+G++ H LE +AK
Sbjct: 255 VSNEKTVVWCSNDYLCLSNNEKIIEVGIETLKKIGNSSGGTRNISGSLLNHTHLEYIIAK 314
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
+ +E+++LF SGY AN+GA+ L K + I++S+E+NHASII+G+R S K I+KH
Sbjct: 315 WYNKESSLLFTSGYIANVGALETL-GKLLNLIYISDEMNHASIINGIRESRCEKFIFKHN 373
Query: 159 DMDDLKK-----KLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAH 213
DM+DL++ ++ + + +K +IV + ++SM G ++ + IV+LA++Y+A+ YVD+ H
Sbjct: 374 DMNDLERILYNLRINKQYENRKIMIVFESIYSMSGHISNIEYIVQLAKKYNALTYVDEVH 433
Query: 214 GEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G+ G+ G G ++ +L + +D GTLSKA G +GG++ + I+ ++ + F+F+
Sbjct: 434 AVGLYGNKGSGYLEELHLCNHIDIINGTLSKAIGSLGGFICANKYYIDVIRSYSSHFIFT 493
Query: 274 SAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYD 333
+++ P ++ + A+ I+Q L KKL + ++ L++ G + + I +M+
Sbjct: 494 TSLTPVNINTSAEAIHIIQNDMSLRKKLTQVVNKTKQKLQERGIQVLHNNSHIVVLMINS 553
Query: 334 EKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKK 393
+ ++ L +EYNI+ Q I YPTVP+G RIR+ PS HT E + ++++ L KK
Sbjct: 554 AEKCKQICDDLLKEYNIYIQPINYPTVPMGMERIRITPSPFHTDEQIFKLVNSLYTLFKK 613
>sp|P43091|HEM1_OPSTA 5-AMINOLEVULINIC ACID SYNTHASE, NONSPECIFIC, MITOCHONDRIAL
PRECURSOR (DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA
SYNTHETASE) (ALAS-H) >gi|532630|gb|AAA49435.1| (L35915)
5-aminolevulinate synthase [Opsanus tau]
Length = 627
Score = 230 bits (580), Expect = 2e-59
Identities = 124/350 (35%), Positives = 200/350 (56%), Gaps = 2/350 (0%)
Query: 48 CSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAIL 107
CSN+YLG++ HP++ +A + + +G GAG R I+GT + HVELE++LA +++AA+L
Sbjct: 236 CSNDYLGMSRHPRVAQAIMETLRKHGSGAGGTRNISGTSKFHVELEQELADLHRKDAALL 295
Query: 108 FQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKL 167
F S + AN + L + S+ NHAS+I G+R SGA K I++H D+ L++ L
Sbjct: 296 FTSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRNSGAKKFIFRHNDVAHLRELL 355
Query: 168 EENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVD 227
E+ K KI+ + V SMDG + PL E+ +LA ++ AI +VD+ H G+ G G GI D
Sbjct: 356 EKGDPTKPKIVAFETVHSMDGAVCPLEEMCDLAHEFGAITFVDEVHAVGLYGPRGGGIGD 415
Query: 228 HFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAA 287
+ K+D GTL KAFG +GGY+A ++ ++ A F+F++++ P +A A +
Sbjct: 416 RDGIMHKMDIISGTLGKAFGCVGGYIASTATLVDTVRSYAAGFIFTTSLPPMLLAGAKQS 475
Query: 288 VEILQKSD--DLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLY 345
++IL+ + L +K N L++ L D G + + I P+ + D + + +
Sbjct: 476 IQILKGEEGCTLRRKHQRNVKLLRQMLMDSGLPVVHCPSHIIPIRVSDAEKNTKVCDLMM 535
Query: 346 EEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
+NI+ QAI YPTV G +R+ P+ HT E +K +D K+ G
Sbjct: 536 SHHNIYVQAINYPTVARGDELLRIAPTPHHTPEMMKYFVDRLVQTWKEVG 585
>sp|O54694|LCB2_CRIGR SERINE PALMITOYLTRANSFERASE 2 (LONG CHAIN BASE BIOSYNTHESIS PROTEIN
2) (LCB 2) (SERINE-PALMITOYL-COA TRANSFERASE 2) (SPT 2)
>gi|2688842|gb|AAC53504.1| (AF004830) serine
palmitoyltransferase LCB2 subunit [Cricetulus griseus]
Length = 560
Score = 230 bits (580), Expect = 2e-59
Identities = 131/368 (35%), Positives = 216/368 (58%), Gaps = 21/368 (5%)
Query: 42 KRVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
K V+NM S NYLG A + +EAA + +YG G + R G ++ H ELE+ +A+F
Sbjct: 166 KGVINMGSYNYLGFARNTGSCQEAAAEVLKEYGAGVCSTRQEIGNLDKHEELEKLVARFL 225
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
EAA+ + G+ N I AL+ KG + LS+ELNHAS++ G RLSGA I+KH +M
Sbjct: 226 GVEAAMTYGMGFATNSMNIPALVGKG--CLILSDELNHASLVLGARLSGATIRIFKHNNM 283
Query: 161 DDLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
L+K L++ + KK +I+ +G++SM+G + LPE++ L ++Y A +Y+D+
Sbjct: 284 QSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDE 343
Query: 212 AHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G LG GRG+VD+F L + VD MGT +K+FG GGY+ G + I+YL+ +
Sbjct: 344 AHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKALIDYLRTHSHSA 403
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYDL-GNTK 323
+++++M+PP + I +++ + D + V++L +NT + ++ L+++G+ + GN
Sbjct: 404 VYATSMSPPVMEQIITSMKCIMGQDGTSLGKECVQQLAENTKYFRRRLKEMGFIIYGNED 463
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLV 383
P+ P+MLY F R + + N+ + +P P+ +R R SAAHTKE L
Sbjct: 464 SPVVPLMLYMPAKIGAFGREMLKR-NVGVVVVGFPATPIIESRARFCLSAAHTKEILDTA 522
Query: 384 IDAFEDLG 391
+ +++G
Sbjct: 523 LKEIDEVG 530
>gi|6320438 5-aminolevulinate synthase; Hem1p [Saccharomyces cerevisiae]
>gi|122831|sp|P09950|HEM1_YEAST 5-AMINOLEVULINIC ACID
SYNTHASE, MITOCHONDRIAL PRECURSOR (DELTA-AMINOLEVULINATE
SYNTHASE) (DELTA-ALA SYNTHETASE) >gi|66533|pir||SYBYAL
5-aminolevulinate synthase (EC 2.3.1.37) precursor,
mitochondrial - yeast (Saccharomyces cerevisiae)
>gi|171662|gb|AAA34668.1| (M26329) 5-aminolevulinate
synthase [Saccharomyces cerevisiae]
>gi|728687|emb|CAA88511.1| (Z48612) Hem1p [Saccharomyces
cerevisiae]
Length = 548
Score = 228 bits (575), Expect = 9e-59
Identities = 127/370 (34%), Positives = 209/370 (56%), Gaps = 22/370 (5%)
Query: 43 RVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKR 102
+V CSN+YL L+ HP++ +A + I YG GAG R IAG + LE +LA K+
Sbjct: 114 KVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKK 173
Query: 103 EAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDD 162
E A++F S Y AN +S L +K +D + S+ELNHAS+I G++ + K I+KH D+++
Sbjct: 174 EGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNE 233
Query: 163 LKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHG 222
L++ L+ K+I + V+SM G +A + +I +LA++Y A+ ++D+ H G+ G HG
Sbjct: 234 LEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHG 293
Query: 223 RGIVDH--FNLH--------------------DKVDFEMGTLSKAFGVIGGYVAGPEEAI 260
G+ +H F H D+VD GTL K+FG +GGYVA + I
Sbjct: 294 AGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLI 353
Query: 261 EYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLG 320
++ + A F+F++ + P +A A AA+ + DL +T +++K +LG +
Sbjct: 354 DWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVI 413
Query: 321 NTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDL 380
I PV++ + LA++ S L ++ I+ QAI +PTV GT R+R+ P+ HT +
Sbjct: 414 PNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLS 473
Query: 381 KLVIDAFEDL 390
++I+A +D+
Sbjct: 474 DILINAVDDV 483
>gb|AAA40724.1| (J04044) delta-aminolevulinate synthase precursor (EC 2.3.1.37)
[Rattus norvegicus]
Length = 642
Score = 228 bits (575), Expect = 9e-59
Identities = 124/360 (34%), Positives = 203/360 (55%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ K+V CSN+YLG++ HP++ A I + +G GAG R I+GT + HVELE++LA
Sbjct: 241 LITKKQVSVWCSNDYLGMSRHPRVCGAVIETVKQHGAGAGGTRNISGTSKFHVELEQELA 300
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+R S PK I++H
Sbjct: 301 DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 360
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D++ L++ L+ + KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 361 NDVNHLRELLQRSDPSLPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL 420
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAFG +GGY+A I+ ++ A F+F++++
Sbjct: 421 YGASGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLP 480
Query: 278 PPDVAAAIAAVEILQKSDD--LVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V IL+ ++ L ++ N +++ L D G + + I PV + D
Sbjct: 481 PMLLAGALESVRILKSNEGRALRRQHQRNVKLMRQMLMDAGLPVIHCPSHIIPVRVADAA 540
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L +NI+ QAI YPTVP G +R+ P+ HT + + ++ K+ G
Sbjct: 541 KNTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFLEKLLLTWKRVG 600
>gb|AAA91867.1| (M63245) mino levulinate synthase [Mus musculus]
Length = 455
Score = 228 bits (574), Expect = 1e-58
Identities = 124/362 (34%), Positives = 202/362 (55%), Gaps = 2/362 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ K+V CSN+YLG++ HP++ A + + +G GAG R I+GT + HVELE+ LA
Sbjct: 54 LITKKQVSVWCSNDYLGMSRHPRVCGAVMETVKQHGAGAGGTRNISGTSKFHVELEQALA 113
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+R S PK I++H
Sbjct: 114 DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 173
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D++ L++ L+ + KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 174 NDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL 233
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAFG +GGY+A + ++ A F+F++++
Sbjct: 234 YGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLTDTVRSYAAGFIFTTSLP 293
Query: 278 PPDVAAAIAAVEILQKSD--DLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V IL+ S+ L ++ N L++ L D G + + I PV + D
Sbjct: 294 PMLLAGALESVRILKSSEGRPLRRQHQRNVKLLRQMLMDAGLPVIHCPSHIIPVRVADAA 353
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L +NI+ QAI YPTVP G +R+ P+ HT + + ++ K+ G
Sbjct: 354 KNTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFVEKLLVTWKRVG 413
Query: 396 FL 397
+
Sbjct: 414 LV 415
>sp|Q92403|HEM1_AGABI 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRIAL PRECURSOR
(DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA SYNTHETASE)
>gi|1679599|emb|CAA90424.1| (Z50096) aminolevulinic acid
synthetase [Agaricus bisporus]
Length = 621
Score = 228 bits (574), Expect = 1e-58
Identities = 130/366 (35%), Positives = 209/366 (56%), Gaps = 26/366 (7%)
Query: 48 CSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAIL 107
CSN+YLG+ +P + E R + YG GAG R IAG +H+ LE +L + ++EAA++
Sbjct: 150 CSNDYLGMGNNPVVLETMHRTLDKYGHGAGGTRNIAGNGAMHLGLEREL-RLHRKEAALV 208
Query: 108 FQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKL 167
F S Y AN +S L K + S+ +NHAS+I GMR S +VI+KH D++DL+ KL
Sbjct: 209 FSSCYVANDATLSTLGTKLPGCVIFSDTMNHASMIQGMRHSTPKRVIFKHNDLEDLETKL 268
Query: 168 EENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVD 227
++ + KII + V+SM G + P+ EI +LAEQY AI ++D+ H G+ G G G+ +
Sbjct: 269 QQYPKETPKIIAFESVYSMCGSIGPVKEICDLAEQYGAITFLDEVHAVGLYGPRGAGVAE 328
Query: 228 HF-----------------NLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
H ++ D++D GTL K++G +GGY+AG EE ++ ++ A F
Sbjct: 329 HLDYDAHLAAGSSPDPIPGSVMDRIDIITGTLGKSYGAVGGYIAGSEEFVDMIRSYAPGF 388
Query: 271 LFSSAMNPPDVAAAIAAVEILQK--SDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITP 328
+F++++ P VA A A++ + D +K++ N +++ L +L + I P
Sbjct: 389 IFTTSLPPATVAGARASIVYQSEYLGDRQLKQI--NVREVKRRLAELDIPVVPGSSHIVP 446
Query: 329 VMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI---- 384
V++ D LA+ S +L E++I+ QAI YPTV G R+R+ + HT E ++ +I
Sbjct: 447 VLVGDAALARAASDKLLSEHDIYVQAINYPTVARGEERLRITVTPRHTMEQMEGLIRSLN 506
Query: 385 DAFEDL 390
FE+L
Sbjct: 507 QVFEEL 512
>sp|Q04512|HEM1_RHOSH 5-AMINOLEVULINIC ACID SYNTHASE 1 (DELTA-AMINOLEVULINATE SYNTHASE)
(DELTA-ALA SYNTHETASE) >gi|151937|gb|AAA72325.1|
(L07490) 5-aminolevulic acid synthase isozyme
[Rhodobacter sphaeroides]
Length = 407
Score = 227 bits (573), Expect = 2e-58
Identities = 130/384 (33%), Positives = 206/384 (52%), Gaps = 7/384 (1%)
Query: 14 LEELKKKGLYVTIRVLQSAQGP-----WVVVNG--KRVLNMCSNNYLGLAAHPKIKEAAI 66
L L +G Y T ++ +G W +G K + C N+YLG+ HP + A
Sbjct: 11 LNRLHTEGRYRTFIDIERRKGAFPKAMWRKPDGSEKEITVWCGNDYLGMGQHPVVLGAMH 70
Query: 67 RAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKG 126
A+ G G+G R I+GT H LE +LA +EAA++F S Y AN +S L +
Sbjct: 71 EALDSTGAGSGGTRNISGTTLYHKRLEAELADLHGKEAALVFSSAYIANDATLSTLPQLI 130
Query: 127 EDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSM 186
+ +S++LNHAS+I+G+R SG K I+KH D+DDL++ L + ++ + V+SM
Sbjct: 131 PGLVIVSDKLNHASMIEGIRRSGTEKHIFKHNDLDDLRRILTSIGKDRPILVAFESVYSM 190
Query: 187 DGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF 246
DGD + EI ++A+++ A+ Y+D+ H G+ G G G+ + L D++D GTL KA+
Sbjct: 191 DGDFGRIEEICDIADEFGALKYIDEVHAVGMYGPRGGGVAERDGLMDRIDIINGTLGKAY 250
Query: 247 GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTH 306
GV GGY+A + + ++ A F+FS+++ P A A A+V L+ +L +K
Sbjct: 251 GVFGGYIAASSKMCDAVRSYAPGFIFSTSLPPVVAAGAAASVRHLKGDVELREKHQTQAR 310
Query: 307 FLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTAR 366
L+ L+ LG + + I PV + D + S L E + I+ Q I +PTVP GT R
Sbjct: 311 ILKMRLKGLGLPIIDHGSHIVPVHVGDPVHCKMISDMLLEHFGIYVQPINFPTVPRGTER 370
Query: 367 IRLEPSAAHTKEDLKLVIDAFEDL 390
+R PS H + ++ A + L
Sbjct: 371 LRFTPSPVHDSGMIDHLVKAMDVL 394
>gb|AAD41464.1|AF086786_1 (AF086786) erythroid-specific 5-aminolevulinic acid synthase
[Delphinapterus leucas]
Length = 582
Score = 226 bits (571), Expect = 3e-58
Identities = 121/342 (35%), Positives = 196/342 (56%), Gaps = 2/342 (0%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
V K V CSN+YLG++ HP++ +A + +G GAG R I+GT HVELE++LA+
Sbjct: 181 VASKDVSVWCSNDYLGMSRHPRVLQATQETLQRHGAGAGGTRNISGTSRFHVELEQELAE 240
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
++++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H
Sbjct: 241 LHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHN 300
Query: 159 DMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVL 218
D D LKK L+++ + KI+ + V SMDG + PL E+ ++A QY A+ +VD+ H G+
Sbjct: 301 DPDHLKKLLKKSNPETPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLY 360
Query: 219 GSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNP 278
GS G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P
Sbjct: 361 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 420
Query: 279 PDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKL 336
++ A+ +V +L ++ L + N +++ L D G + I P+ + D L
Sbjct: 421 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGDAAL 480
Query: 337 AQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKE 378
L ++ I+ QAI YPTVP G +RL PS H+ +
Sbjct: 481 NSRICDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQ 522
>emb|CAA39795.1| (X56352) delta-aminolevulinate synthase (erythroid) [Homo sapiens]
Length = 582
Score = 226 bits (570), Expect = 4e-58
Identities = 121/342 (35%), Positives = 198/342 (57%), Gaps = 2/342 (0%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
V K V CSN+YLG++ HP++ +A + +G GAG R I+GT + HVELE++LA+
Sbjct: 181 VASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAE 240
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
++++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H
Sbjct: 241 LHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHN 300
Query: 159 DMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVL 218
D D LKK LE++ K KI+ + V SMDG + PL E+ +++ QY A+ +VD+ H G+
Sbjct: 301 DPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 360
Query: 219 GSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNP 278
GS G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P
Sbjct: 361 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 420
Query: 279 PDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKL 336
++ A+ +V +L ++ L + N +++ L D G + I P+ + + L
Sbjct: 421 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAAL 480
Query: 337 AQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKE 378
+ L ++ I+ QAI YPTVP G +RL PS H+ +
Sbjct: 481 NSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQ 522
>gi|11420071 aminolevulinate, delta-, synthase 2 [Homo sapiens]
>gi|2144401|pir||SYHUAE 5-aminolevulinate synthase (EC
2.3.1.37) precursor, erythroid-specific, mitochondrial -
human >gi|28588|emb|CAA42916.1| (X60364)
5-aminolevulinate synthase precursor [Homo sapiens]
>gi|3150092|emb|CAA15886.1| (AL020991) dJ884M20.2 [Homo
sapiens] >gi|3220249|gb|AAC39838.1| (AF068624)
5-aminolevulinate synthase 2 [Homo sapiens]
Length = 587
Score = 226 bits (570), Expect = 4e-58
Identities = 121/342 (35%), Positives = 198/342 (57%), Gaps = 2/342 (0%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
V K V CSN+YLG++ HP++ +A + +G GAG R I+GT + HVELE++LA+
Sbjct: 186 VASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAE 245
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
++++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H
Sbjct: 246 LHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHN 305
Query: 159 DMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVL 218
D D LKK LE++ K KI+ + V SMDG + PL E+ +++ QY A+ +VD+ H G+
Sbjct: 306 DPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 365
Query: 219 GSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNP 278
GS G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P
Sbjct: 366 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425
Query: 279 PDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKL 336
++ A+ +V +L ++ L + N +++ L D G + I P+ + + L
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAAL 485
Query: 337 AQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKE 378
+ L ++ I+ QAI YPTVP G +RL PS H+ +
Sbjct: 486 NSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQ 527
>pir||SYMSAL 5-aminolevulinate synthase (EC 2.3.1.37) precursor,
erythroid-specific, mitochondrial - mouse (fragment)
>gi|387096|gb|AAA37207.1| (M15268) 5-aminolevulinic acid
synthase (EC 2.3.1.37) [Mus musculus]
Length = 586
Score = 226 bits (570), Expect = 4e-58
Identities = 119/346 (34%), Positives = 203/346 (58%), Gaps = 2/346 (0%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
K V CSN+YLG++ HP++ +A + ++G GAG R I+GT + HVELE++LA+ +
Sbjct: 188 KDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHQ 247
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H D
Sbjct: 248 KDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPG 307
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
LKK LE++ K KI+ + V SMDG + PL E+ ++A QY A+ +VD+ H G+ G+
Sbjct: 308 HLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLYGAR 367
Query: 222 GRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDV 281
G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P +
Sbjct: 368 GAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMML 427
Query: 282 AAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQE 339
+ A+ +V +L ++ L + N +++ L D G+ + I P+ + + L +
Sbjct: 428 SGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSK 487
Query: 340 FSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVID 385
L +++I+ QAI YPTVP G +RL PS H+ + ++ ++
Sbjct: 488 ICDLLLSKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVE 533
>gi|4557299 aminolevulinate, delta-, synthase 2; Aminolevulinate, delta-,
synthase-2 [Homo sapiens]
>gi|122816|sp|P22557|HEM0_HUMAN 5-AMINOLEVULINIC ACID
SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL PRECURSOR
(DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA SYNTHETASE)
(ALAS-E)
Length = 587
Score = 226 bits (570), Expect = 4e-58
Identities = 121/342 (35%), Positives = 198/342 (57%), Gaps = 2/342 (0%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
V K V CSN+YLG++ HP++ +A + +G GAG R I+GT + HVELE++LA+
Sbjct: 186 VASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAE 245
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
++++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H
Sbjct: 246 LHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHN 305
Query: 159 DMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVL 218
D D LKK LE++ K KI+ + V SMDG + PL E+ +++ QY A+ +VD+ H G+
Sbjct: 306 DPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 365
Query: 219 GSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNP 278
GS G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P
Sbjct: 366 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425
Query: 279 PDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKL 336
++ A+ +V +L ++ L + N +++ L D G + I P+ + + L
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAAL 485
Query: 337 AQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKE 378
+ L ++ I+ QAI YPTVP G +RL PS H+ +
Sbjct: 486 NSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQ 527
>emb|CAB06076.1| (Z83821) 5-aminolevulinic acid synthase [Homo sapiens]
Length = 582
Score = 226 bits (570), Expect = 4e-58
Identities = 121/342 (35%), Positives = 198/342 (57%), Gaps = 2/342 (0%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
V K V CSN+YLG++ HP++ +A + +G GAG R I+GT + HVELE++LA+
Sbjct: 181 VASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAE 240
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
++++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H
Sbjct: 241 LHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHN 300
Query: 159 DMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVL 218
D D LKK LE++ K KI+ + V SMDG + PL E+ +++ QY A+ +VD+ H G+
Sbjct: 301 DPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 360
Query: 219 GSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNP 278
GS G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P
Sbjct: 361 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 420
Query: 279 PDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKL 336
++ A+ +V +L ++ L + N +++ L D G + I P+ + + L
Sbjct: 421 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAAL 480
Query: 337 AQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKE 378
+ L ++ I+ QAI YPTVP G +RL PS H+ +
Sbjct: 481 NSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQ 522
>gb|AAD20807.1| (AF073338) 5-aminolevulinate synthase [Glycera dibranchiata]
Length = 599
Score = 226 bits (569), Expect = 5e-58
Identities = 120/347 (34%), Positives = 200/347 (57%), Gaps = 3/347 (0%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
K + CSN+YLG++ +PK++EA + A+ +G GAG R I+G H LE+++A +
Sbjct: 198 KNITVWCSNDYLGMSWNPKVQEAVVEALYSHGAGAGGTRNISGNSPYHEALEKEIADLHQ 257
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+E A+LF S Y AN ++ L + S+ NHAS+I G+ SG PK +++H D +
Sbjct: 258 KEGALLFTSCYVANDSTLATLAKMLPGCQVFSDSGNHASMIQGIIRSGMPKHVFRHNDPE 317
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
L++ + + KI+ + V SM G + PL E+ ++A +Y AI ++D+ H G+ G H
Sbjct: 318 HLEELISKVDVSIPKIVAFETVHSMTGAICPLQEMCDIAHKYGAITFIDEVHAVGLYGKH 377
Query: 222 GRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDV 281
G GI + NL ++D GTL KAFG IGGY+AG ++ L+ A F+F++++ P +
Sbjct: 378 GAGIGERDNLLHEMDIISGTLGKAFGNIGGYIAGSAALVDMLRSYASGFIFTTSLPPTVL 437
Query: 282 AAAIAAVEILQKSDD--LVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQE 339
A ++++L K D+ + + N +L+ L D G + + I P+ + + KL ++
Sbjct: 438 YGARRSIQVL-KGDEGRIAPRHQANVKYLRDHLTDAGLPVIHAPSHIIPIHVGEPKLCRK 496
Query: 340 FSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
+ L EE+ I+ Q I YPTVP G +R+ P+ HTKE + ++A
Sbjct: 497 LADELMEEHGIYVQPINYPTVPRGQELLRVAPTPHHTKEMMDSFVNA 543
>gi|6978485 aminolevulinate synthase 2, delta [Rattus norvegicus]
>gi|6166201|sp|Q63147|HEM0_RAT 5-AMINOLEVULINIC ACID
SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL PRECURSOR
(DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA SYNTHETASE)
(ALAS-E) >gi|1407568|dbj|BAA13063.1| (D86297) rat
erythroid-specific delta-aminolevulinate synthase (rat
ALAS-E) [Rattus norvegicus]
Length = 587
Score = 225 bits (568), Expect = 6e-58
Identities = 119/349 (34%), Positives = 204/349 (58%), Gaps = 2/349 (0%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
++ K V CSN+YLG++ HP++ +A + ++G GAG R I+GT + HVELE++LA+
Sbjct: 186 MDSKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAE 245
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
+++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H
Sbjct: 246 LHHKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAVKFVFRHN 305
Query: 159 DMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVL 218
D LKK LE++ K KI+ + V SMDG + PL E+ ++A QY A+ +VD+ H G+
Sbjct: 306 DPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLY 365
Query: 219 GSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNP 278
G+ G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P
Sbjct: 366 GTRGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425
Query: 279 PDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKL 336
++ A+ +V +L ++ L + N +++ L D G+ + I P+ + + L
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAAL 485
Query: 337 AQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVID 385
+ L +++I+ QAI YPTVP G +RL PS H+ + ++ ++
Sbjct: 486 NSKICDLLLAKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVE 534
>gi|4502025 aminolevulinate, delta-, synthase 1 [Homo sapiens]
>gi|122824|sp|P13196|HEM1_HUMAN 5-AMINOLEVULINIC ACID
SYNTHASE, NONSPECIFIC, MITOCHONDRIAL PRECURSOR
(DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA SYNTHETASE)
(ALAS-H) >gi|2144400|pir||SYHUAL 5-aminolevulinate
synthase (EC 2.3.1.37) precursor, nonspecific,
mitochondrial - human >gi|28583|emb|CAA39794.1| (X56351)
delta- aminolevulinate synthase (housekeeping) [Homo
sapiens]
Length = 640
Score = 225 bits (567), Expect = 8e-58
Identities = 122/360 (33%), Positives = 201/360 (54%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ K+V CSN+YLG++ HP++ A + + +G GAG R I+GT + HV+LE +LA
Sbjct: 239 LITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELA 298
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+R S PK I++H
Sbjct: 299 DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 358
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D+ L++ L+ + KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 359 NDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL 418
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAFG +GGY+A I+ ++ A F+F++++
Sbjct: 419 YGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLP 478
Query: 278 PPDVAAAIAAVEILQKSDDLV--KKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V IL+ ++ V ++ N +++ L D G + + I PV + D
Sbjct: 479 PMLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAA 538
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L +NI+ QAI YPTVP G +R+ P+ HT + + ++ K+ G
Sbjct: 539 KNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVG 598
>gi|11449702 aminolevulinate, delta-, synthase 1 [Homo sapiens]
Length = 665
Score = 225 bits (567), Expect = 8e-58
Identities = 122/360 (33%), Positives = 201/360 (54%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ K+V CSN+YLG++ HP++ A + + +G GAG R I+GT + HV+LE +LA
Sbjct: 264 LITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELA 323
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+R S PK I++H
Sbjct: 324 DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 383
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D+ L++ L+ + KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 384 NDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL 443
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAFG +GGY+A I+ ++ A F+F++++
Sbjct: 444 YGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLP 503
Query: 278 PPDVAAAIAAVEILQKSDDLV--KKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V IL+ ++ V ++ N +++ L D G + + I PV + D
Sbjct: 504 PMLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAA 563
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L +NI+ QAI YPTVP G +R+ P+ HT + + ++ K+ G
Sbjct: 564 KNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVG 623
>pir||C49845 5-aminolevulinate synthase (EC 2.3.1.37) HemA - Rhodobacter
sphaeroides
Length = 407
Score = 224 bits (565), Expect = 1e-57
Identities = 129/384 (33%), Positives = 205/384 (52%), Gaps = 7/384 (1%)
Query: 14 LEELKKKGLYVTIRVLQSAQGP-----WVVVNG--KRVLNMCSNNYLGLAAHPKIKEAAI 66
L L +G Y T ++ +G W +G K + C N+YLG+ HP + A
Sbjct: 11 LNRLHTEGRYRTFIDIERRKGAFPKAMWRKPDGSEKEITVWCGNDYLGMGQHPVVLGAMH 70
Query: 67 RAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKG 126
A+ G G+G R I+GT H LE +LA +EAA++F S Y AN +S L +
Sbjct: 71 EALDSTGAGSGGTRNISGTTLYHKRLEAELADLHGKEAALVFSSAYIANDATLSTLPQLI 130
Query: 127 EDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSM 186
+ +S++LNHAS+I+G+R SG K I+KH D+DDL++ L + ++ + V+SM
Sbjct: 131 PGLVIVSDKLNHASMIEGIRRSGTEKHIFKHNDLDDLRRILTSIGKDRPILVAFESVYSM 190
Query: 187 DGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF 246
DGD + EI ++A+++ A+ Y+D+ H G+ G G G+ + L D++D GTL KA+
Sbjct: 191 DGDFGRIEEICDIADEFGALKYIDEVHAVGMYGPRGGGVAERDGLMDRIDIINGTLGKAY 250
Query: 247 GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTH 306
GV GGY+A + + ++ A F+FS+++ P A A A+V L+ +L +K
Sbjct: 251 GVFGGYIAASSKMCDAVRSYAPGFIFSTSLPPVVAAGAAASVRHLKGDVELREKHQTQAR 310
Query: 307 FLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTAR 366
L+ L+ LG + + I PV + D + S L + I+ Q I +PTVP GT R
Sbjct: 311 ILKMRLKGLGLPIIDHGSHIVPVHVGDPVHCKMISDMLLIHFGIYVQPINFPTVPRGTER 370
Query: 367 IRLEPSAAHTKEDLKLVIDAFEDL 390
+R PS H + ++ A + L
Sbjct: 371 LRFTPSPVHDSGMIDHLVKAMDVL 394
>sp|P08680|HEM0_MOUSE 5-AMINOLEVULINIC ACID SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL
PRECURSOR (DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA
SYNTHETASE) (ALAS-E)
Length = 572
Score = 223 bits (563), Expect = 2e-57
Identities = 120/347 (34%), Positives = 203/347 (57%), Gaps = 4/347 (1%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
K V CSN+YLG++ HP++ +A + ++G GAG R I+GT + HVELE++LA+ +
Sbjct: 174 KDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHQ 233
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H D
Sbjct: 234 KDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPG 293
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
LKK LE++ K KI+ + V SMDG + PL E+ ++A QY A+ +VD+ H G+ G+
Sbjct: 294 HLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLYGAW 353
Query: 222 GRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDV 281
G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P +
Sbjct: 354 GAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTWDLVDMVRSYAAGFIFTTSLPPMML 413
Query: 282 AAAIAAVEILQKSDDLVKKLW---DNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQ 338
+ A+ +V +L K ++ W N +++ L D G+ + I P+ + + L
Sbjct: 414 SGALESVRLL-KGEEGQALRWAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNS 472
Query: 339 EFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVID 385
+ L +++I+ QAI YPTVP G +RL PS H+ + ++ ++
Sbjct: 473 KICDLLLSKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVE 519
>gb|AAD20806.1| (AF073337) 5-aminolevulinate synthase [Delphinapterus leucas]
Length = 640
Score = 223 bits (563), Expect = 2e-57
Identities = 122/360 (33%), Positives = 200/360 (54%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
+V K+V CSN+YLG++ HP++ A + + +G GAG R I+GT + HV+LE++LA
Sbjct: 239 LVTKKQVSVWCSNDYLGMSCHPRVCGAVMDTLKQHGTGAGGTRNISGTSKFHVDLEQELA 298
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+ S PK IY+H
Sbjct: 299 DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIWNSRVPKYIYRH 358
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D+D L++ L+ + KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 359 NDVDHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL 418
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAFG +GGY+A I+ ++ A F+F++++
Sbjct: 419 YGAQGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTIRSYAAGFIFTTSLP 478
Query: 278 PPDVAAAIAAVEILQKSDDLV--KKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V IL+ ++ V ++ N +++ L D + + I PV + D
Sbjct: 479 PMLLAGALESVRILKSTEGRVLRRQHQRNVKLMRQMLMDASLPVVHCPSHIIPVRVADAA 538
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L +NI+ QAI YPTV G +R+ P+ HT + + ++ K+ G
Sbjct: 539 KNTEVCNELMSRHNIYVQAINYPTVRRGEELLRIAPTPHHTPQMMNYFVENLLATWKRVG 598
>sp|P13195|HEM1_RAT 5-AMINOLEVULINIC ACID SYNTHASE, NONSPECIFIC, MITOCHONDRIAL
PRECURSOR (DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA
SYNTHETASE) (ALAS-H) >gi|66529|pir||SYRTAL
5-aminolevulinate synthase (EC 2.3.1.37) precursor,
nonspecific, mitochondrial - rat
>gi|203068|gb|AAA40790.1| (J03190) 5-aminolevulinate
synthase precursor [Rattus norvegicus]
Length = 642
Score = 222 bits (561), Expect = 4e-57
Identities = 122/360 (33%), Positives = 201/360 (54%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ +V SN+YLG++ HP++ A I + +G GAG R I+GT + HVELE++LA
Sbjct: 241 LITNNQVSVWSSNDYLGMSRHPRVCGAVIETVKQHGAGAGGTRNISGTSKFHVELEQELA 300
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+R S PK I++H
Sbjct: 301 DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 360
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D++ L++ L+ + KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 361 NDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL 420
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAFG +GGY+A I+ ++ A F+F++++
Sbjct: 421 YGASGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLP 480
Query: 278 PPDVAAAIAAVEILQKSDD--LVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V IL+ ++ L ++ N +++ L D G + + I PV + D
Sbjct: 481 PMLLAGALESVRILKSNEGRALRRQHQRNVKLMRQMLMDAGLPVIHCPSHIIPVRVADAA 540
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L +NI+ QAI YPTVP G +R+ P+ HT + + ++ K+ G
Sbjct: 541 KNTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLEKLLLTWKRVG 600
>gb|AAC72835.1| (AF095747) aminolevulinate synthase erythroid specific isoform
[Danio rerio]
Length = 583
Score = 222 bits (561), Expect = 4e-57
Identities = 123/358 (34%), Positives = 201/358 (55%), Gaps = 4/358 (1%)
Query: 41 GKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
G +V CSN+YLG++ HP++ +A A+ +G GAG R I+GT HV LE +LA+
Sbjct: 183 GSQVSVWCSNDYLGMSRHPRVVKAIGDALKKHGAGAGGTRNISGTSNYHVALENELARLH 242
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
+++ A++F S + AN + L + S+ NHAS+I G+R SGA + I++H D
Sbjct: 243 QKDGALVFSSCFVANDSTLFTLAKMLPGCEIYSDMGNHASMIQGIRNSGAKRFIFRHNDA 302
Query: 161 DDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGS 220
L++ L + KI+ + V SMDG + PL E+ ++A +Y A+ +VD+ H G+ G+
Sbjct: 303 SHLEELLSRSDPLTPKIVAFETVHSMDGAICPLEELCDVAHKYGALTFVDEVHAVGLYGA 362
Query: 221 HGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPD 280
HG G+ + N+ K+D GTL KAFG +GGY+A ++ ++ A F+F++++ P
Sbjct: 363 HGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFAAGFIFTTSLPPMV 422
Query: 281 VAAAIAAVEILQKSDD---LVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLA 337
+A A+ +V +L KSD+ L + N +++ L D G + N I P+ + +
Sbjct: 423 LAGALESVRVL-KSDEGQALRRAHQRNVKHMRQLLLDAGLPVVNCPSHIIPIRVGNAAKN 481
Query: 338 QEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L E++NI+ QAI YPTVP G +RL PS H + + D+ ++ G
Sbjct: 482 SEVCDILLEKHNIYVQAINYPTVPRGEELLRLAPSPFHNPIMMNYFAEKLLDVWQEVG 539
>pir||JX0278 5-aminolevulinate synthase (EC 2.3.1.37) precursor,
erythroid-specific, mitochondrial - rat
Length = 587
Score = 221 bits (558), Expect = 9e-57
Identities = 119/349 (34%), Positives = 202/349 (57%), Gaps = 2/349 (0%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAK 98
++ K V CSN+YLG++ HP++ +A + ++G GAG R I+GT + HVELE++LA+
Sbjct: 186 MDSKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAE 245
Query: 99 FKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHL 158
+++A+LF S + AN + L + S+ NHASII G+R SGA K +++H
Sbjct: 246 LHHKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASIIQGIRNSGAVKFVFRHN 305
Query: 159 DMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVL 218
D LKK LE++ K KI+ + V SMDG + PL E+ ++A QY A+ +VD+ H G+
Sbjct: 306 DPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLY 365
Query: 219 GSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNP 278
G+ G GI + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P
Sbjct: 366 GTRGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425
Query: 279 PDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKL 336
++ A+ +V +L ++ L + N +++ L D G+ + I P+ + + L
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFLVIPCPSHIIPIRVGNAAL 485
Query: 337 AQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVID 385
+ L + + + QAI YPTVP G +RL PS H+ + ++ ++
Sbjct: 486 NSKICDLLLAKQSNYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVE 534
>gb|AAD20809.1| (AF073340) 5-aminolevulinate synthase [Strongylocentrotus
droebachiensis]
Length = 592
Score = 221 bits (558), Expect = 9e-57
Identities = 121/361 (33%), Positives = 197/361 (54%), Gaps = 2/361 (0%)
Query: 37 VVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKL 96
V G V CSN+YLG++ HPK+K+A + +G GAG R I+G H LE K+
Sbjct: 183 VNAEGLPVTVWCSNDYLGMSRHPKVKQAVADTMAKHGTGAGGTRNISGNTTFHEALEAKV 242
Query: 97 AKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYK 156
AK +++A ++F S Y AN + L + S+E NHAS+I G+R S APK I++
Sbjct: 243 AKLHQKDAGLVFTSCYVANDSTLYTLAKLLPGCEIYSDEGNHASMIQGIRNSQAPKFIFR 302
Query: 157 HLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEG 216
H D L++ L + KI+ + V SM G + PL E+ ++A +Y AI +VD+ H G
Sbjct: 303 HNDPTHLEEMLRKADPLTPKIVAFETVHSMTGAICPLKEMCDVAHKYGAITFVDEVHAVG 362
Query: 217 VLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAM 276
+ G HG G+ + +D GTL KAFG+IGGY+ G ++ ++ A F+F++++
Sbjct: 363 LYGRHGAGVGERDGCMADMDIVSGTLGKAFGMIGGYIVGDNALVDMVRSYAAGFIFTTSL 422
Query: 277 NPPDVAAAIAAVEILQKSDD--LVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDE 334
P +A A+A++++L + L K D ++ L G + + I P+ + +
Sbjct: 423 PPMVLAGAMASIDVLSGEEGVALRTKHQDTVSMMRGKLIAAGLPVVHCPSHIIPIHVGNP 482
Query: 335 KLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKT 394
+ + L EE+NI+ QAI PTVP G ++R+ PS HT + + + + ++ K+
Sbjct: 483 RANTNVANSLLEEHNIYVQAINSPTVPSGEEKLRIAPSPXHTPDMMDRFVASLSEVWAKS 542
Query: 395 G 395
G
Sbjct: 543 G 543
>emb|CAA74915.1| (Y14577) delta-aminolevulinate synthase [Drosophila melanogaster]
>gi|2330591|emb|CAA74914.1| (Y14576)
delta-aminolevulinate synthase [Drosophila melanogaster]
>gi|7291697|gb|AAF47119.1| (AE003462) Alas gene product
[Drosophila melanogaster]
Length = 539
Score = 221 bits (557), Expect = 1e-56
Identities = 121/345 (35%), Positives = 195/345 (56%), Gaps = 2/345 (0%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
K + CSN+YLG++AHP +K A A+ +G GAG R I+G H LE KLA+ +
Sbjct: 139 KPITVWCSNDYLGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLESKLAELHQ 198
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+EAA+LF S + AN + L + S+ NHAS+I G+R SG PK I++H D+D
Sbjct: 199 KEAALLFTSCFVANDSTLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHNDVD 258
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
L + L++ KI+ + V SM G + PL E++++A ++ AI ++D+ H G+ G H
Sbjct: 259 HLHQLLKQTDKSVPKIVAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDH 318
Query: 222 GRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDV 281
G G+ + + K+D GTL KAFG IGGY+AG ++ ++ A F+F++++ P +
Sbjct: 319 GAGVGERDGVLHKMDIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVL 378
Query: 282 AAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQE 339
A+ AV IL ++ L N +L+ L+ G+ + T I P+ + D + +
Sbjct: 379 CGALEAVNILASEEGRQLRHLHQRNVSYLKSLLKREGFPVEETPSHIIPIKIGDPLKSSQ 438
Query: 340 FSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
S L E++ + Q+I YPTV G ++RL P+ HT E + ++
Sbjct: 439 ISNVLIEQFGHYLQSINYPTVARGQEKLRLAPTPFHTFEMMNALV 483
>sp|O94069|HEM1_CANAL 5-AMINOLEVULINIC ACID SYNTHASE, MITOCHONDRIAL PRECURSOR
(DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA SYNTHETASE)
>gi|7493758|pir||T18251 5-aminolevulinate synthase (EC
2.3.1.37) - yeast (Candida albicans)
>gi|3859685|emb|CAA22025.1| (AL033503) 5-aminolevulinic
acid synthase [Candida albicans]
Length = 564
Score = 221 bits (557), Expect = 1e-56
Identities = 123/366 (33%), Positives = 204/366 (55%), Gaps = 20/366 (5%)
Query: 43 RVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKR 102
+V CSN+YLG+ + + R + YG GAG R IAG ++LE +LA K
Sbjct: 136 KVTVWCSNDYLGMGKNENTLKEMKRVLDKYGSGAGGTRNIAGHNSHAIKLESELAALHKH 195
Query: 103 EAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDD 162
+AA++F S + AN +S L +K +D + S+ELNHAS+I G+R S A K I+KH ++ D
Sbjct: 196 DAALVFSSCFVANDAVLSLLGQKIKDLVIFSDELNHASMIQGIRNSRARKHIFKHNNLAD 255
Query: 163 LKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHG 222
L+ KL + K+I + V+SM G +AP+ I +LAE+Y A+ ++D+ H G+ G HG
Sbjct: 256 LESKLAQYPKSTPKLIAFESVYSMCGSIAPIEAICDLAEKYGALTFLDEVHAVGMYGPHG 315
Query: 223 RGIVDHFNLH----------------DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQR 266
G+ +H N +VD GTL KA+GV+GGY+ G I++ +
Sbjct: 316 AGVAEHLNFEAHLKSGIERPEITTVMSRVDMVTGTLGKAYGVVGGYITGKTNLIDWFRSY 375
Query: 267 ARPFLFSSAMNPPDVAAAIAAVEILQKS--DDLVKKLWDNTHFLQKGLRDLGYDLGNTKH 324
A F+F++++ P +A A++ + + D + ++ NT ++ L +LG +
Sbjct: 376 APGFIFTTSLPPAIMAGCSASIRYQRATLKDRIAQQ--KNTRLVKNNLNELGIPVIPNPS 433
Query: 325 PITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
I PV++ + A+ S L +++I+ QAI +PTVP+G R+R+ P+ H E K ++
Sbjct: 434 HIVPVLVGNAADAKRASDLLLNKHDIYVQAINFPTVPIGEERLRITPTPGHGPELSKQLV 493
Query: 385 DAFEDL 390
+A + +
Sbjct: 494 EAVDSV 499
>emb|CAB44316.1| (AJ242659) serine palmitoyltransferase [Solanum tuberosum]
Length = 489
Score = 220 bits (556), Expect = 2e-56
Identities = 126/371 (33%), Positives = 208/371 (55%), Gaps = 21/371 (5%)
Query: 43 RVLNMCSNNYLGLAAHPKI-KEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
R LN+ S NYLG AA + I ++ Y + R GT +H+ELEE +A F
Sbjct: 101 RCLNLGSYNYLGFAASDEYCTPRVIESLKKYSASTCSARVDGGTTSIHMELEECVANFVG 160
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+ AAI+ GY N + L+ KG G+ +S+ LNH SI++G R SGA +++H
Sbjct: 161 KPAAIVTGMGYVTNSAILPVLIGKG--GLIISDSLNHNSIVNGARGSGATIRVFQHNTPS 218
Query: 162 DLKKKLEEN---------KDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDA 212
L+K L E+ + KK I++ +G++SM+G+L LPEIV + ++Y VY+D+A
Sbjct: 219 HLEKVLREHIAEGQPRTHRPWKKIIVIVEGIYSMEGELCQLPEIVAICKKYKVYVYLDEA 278
Query: 213 HGEGVLGSHGRGIVDHFNLHD-KVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFL 271
H G +G GRG+ + + VD MGT +K+FG GGY+AG +E IEYLK L
Sbjct: 279 HSIGAVGKSGRGVCELLGVDTADVDIMMGTFTKSFGSCGGYIAGSKELIEYLKYSCPAHL 338
Query: 272 FSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYD-LGNTKH 324
++++++PP I+A++++ D + ++ +N++F + L+ +G++ LG+
Sbjct: 339 YATSISPPAAQQIISAIKVILGEDGTSRGAQKLARIRENSNFFRSELQKMGFEVLGDNDS 398
Query: 325 PITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
P+ P+M+Y+ FSR + ++ + +P PL AR R+ SAAH++EDL + +
Sbjct: 399 PVMPIMIYNPGKIPAFSRECLKR-SVAVVIVGFPATPLLLARARICISAAHSREDLNIAL 457
Query: 385 DAFEDLGKKTG 395
+ +G TG
Sbjct: 458 EVISKVGDLTG 468
>sp|P43089|HEM1_PARDE 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINOLEVULINATE SYNTHASE)
(DELTA-ALA SYNTHETASE) >gi|537435|gb|AAA62279.1|
(U12508) 5-aminolevulinic acid synthase [Paracoccus
denitrificans]
Length = 409
Score = 220 bits (555), Expect = 2e-56
Identities = 128/391 (32%), Positives = 214/391 (53%), Gaps = 11/391 (2%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGP-----WVVVNGK--RVLNMCSNNYLGLAAHPKIK 62
+ + + +L ++G Y T ++ +G W +G R+ C N+YLG+ HP +
Sbjct: 7 LDQAIGKLHEEGRYRTFIDIERRKGAYPTAVWTRPDGTETRITVWCGNDYLGMGQHPVVL 66
Query: 63 EAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISAL 122
A A+ G G+G R I+GT H LE +LA +EAA++F S Y AN +S L
Sbjct: 67 AAMHEALDATGAGSGGTRNISGTTVYHKRLEAELADLHGKEAALVFSSVYIANDATLSTL 126
Query: 123 LRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDG 182
+ I S+ELNHAS+I+G++ S APK I++H D+ L++ L + + K+I +
Sbjct: 127 RKLFPGLIIYSDELNHASMIEGIKRSTAPKRIFRHNDVGHLRELLAADDPEAPKLIAFES 186
Query: 183 VFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTL 242
++SMDGD AP+ EI +LA++++A+ Y+D+ H G+ G G G+ + L ++D GTL
Sbjct: 187 IYSMDGDFAPIKEICDLADEFNALTYLDEVHAVGMYGPRGGGVAERDGLSHRIDIFNGTL 246
Query: 243 SKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDD---LVK 299
+KAFGV GGY+ ++ ++ A F+F++++ PP VAA +AA K+ + +
Sbjct: 247 AKAFGVFGGYIGFGARMVDAIRSYAPGFIFTTSL-PPAVAAGVAASIAFLKTAEGQFVRD 305
Query: 300 KLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPT 359
+ N L+ LR G + + I PV + + + S L +++I+ Q I +PT
Sbjct: 306 QQQLNGRLLKMRLRGAGMPVMDHGSHIVPVHVGNPVHCKALSDMLLADFSIYVQPINFPT 365
Query: 360 VPLGTARIRLEPSAAHTKEDLKLVIDAFEDL 390
VP GT R+R S H + + ++ A + L
Sbjct: 366 VPRGTERLRFTASPVHDPKQIDHLVKAMDSL 396
>sp|P18079|HEM1_RHOCA 5-AMINOLEVULINIC ACID SYNTHASE (DELTA-AMINOLEVULINATE SYNTHASE)
(DELTA-ALA SYNTHETASE) >gi|97435|pir||S10528
5-aminolevulinate synthase (EC 2.3.1.37) - Rhodobacter
capsulatus >gi|46029|emb|CAA37393.1| (X53309)
delta-aminolevulinic acid synthase (AA 1-401)
[Rhodobacter capsulatus] >gi|974202|emb|CAA37857.1|
(X53864) 5-aminolevulinic acid synthase [Rhodobacter
capsulatus]
Length = 401
Score = 219 bits (553), Expect = 4e-56
Identities = 121/390 (31%), Positives = 210/390 (53%), Gaps = 13/390 (3%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKR-------VLNMCSNNYLGLAAHPKIK 62
+ + +++L +G Y T ++ +G + R + C N+YLG+ HP +
Sbjct: 7 LDKAIQKLHDEGRYRTFIDIEREKGAFPKAQWNRPDGGKQDITVWCGNDYLGMGQHPVVL 66
Query: 63 EAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISAL 122
A A+ G G+G R I+GT H LE ++A +EAA++F S Y AN +S L
Sbjct: 67 AAMHEALEAVGAGSGGTRNISGTTAYHRRLEAEIADLHGKEAALVFSSAYIANDATLSTL 126
Query: 123 LRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDG 182
I S+ LNHAS+I+G++ + PK I++H D+ L++ + + K+I +
Sbjct: 127 RLLFPGLIIYSDSLNHASMIEGIKRNAGPKRIFRHNDVAHLRELIAADDPAAPKLIAFES 186
Query: 183 VFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTL 242
V+SMDGD P+ EI ++A+++ A+ Y+D+ H G+ G G G+ + L ++D GTL
Sbjct: 187 VYSMDGDFGPIKEICDIADEFGALTYIDEVHAVGMYGPRGAGVAERDGLMHRIDIFNGTL 246
Query: 243 SKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLW 302
+KA+GV GGY+A + ++ ++ A F+FS+++ P A A A++ L+ ++ +KL
Sbjct: 247 AKAYGVFGGYIAASAKMVDAVRSYAPGFIFSTSLPPAIAAGAQASIAFLKTAEG--QKLR 304
Query: 303 D----NTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYP 358
D + L+ L+ LG + + I PV++ D + S L +Y ++ Q I +P
Sbjct: 305 DAQQMHAKVLKMRLKALGMPIIDHGSHIVPVVIGDPVHTKAVSDMLLSDYGVYVQPINFP 364
Query: 359 TVPLGTARIRLEPSAAHTKEDLKLVIDAFE 388
TVP GT R+R PS H + + ++ A +
Sbjct: 365 TVPRGTERLRFTPSPVHDLKQIDGLVHAMD 394
>emb|CAB65865.1| (AL109983) dJ718P11.1.1 (novel class II aminotransferase similar to
serine palmotyltransferase (isoform 1)) [Homo sapiens]
Length = 414
Score = 219 bits (551), Expect = 6e-56
Identities = 130/357 (36%), Positives = 208/357 (57%), Gaps = 21/357 (5%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILD-YGVGAGAVRTIAGTMELHVELEEKLAKFK 100
K V+NM S N+LGLAA I+ +L+ YG G + R GT++ H ELE+ +AKF
Sbjct: 59 KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFL 118
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
EAA++F G+ N I AL+ KG + LS+ELNH S++ G RLSGA I+KH +
Sbjct: 119 NVEAAMVFGMGFATNSMNIPALVGKG--CLILSDELNHTSLVLGARLSGATIRIFKHNNT 176
Query: 161 DDLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
L+K L + + KK +I+ +GV+SM+G + LP+I+ L ++Y A +Y+D+
Sbjct: 177 QSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDE 236
Query: 212 AHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G +G GRG+ + F L +VD MGT +K+FG GGY+AG ++ ++YL+ +
Sbjct: 237 AHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSA 296
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYDL-GNTK 323
+++S+M+PP I +++++ D V++L NT + ++ L+++G+ + GN
Sbjct: 297 VYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNEN 356
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDL 380
+ P++LY F+R + E+ I + +P PL AR R SAAHT+E L
Sbjct: 357 ASVVPLLLYMPGKVAAFARHMLEK-KIGVVVVGFPATPLAEARARFCVSAAHTREML 412
>emb|CAA68506.1| (Y00451) 5-aminolevulinate synthase precursor [Homo sapiens]
Length = 642
Score = 218 bits (550), Expect = 8e-56
Identities = 118/360 (32%), Positives = 202/360 (55%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ K+V CSN+YLG++ HP++ A + + +G GAG R I+GT + HV+LE +LA
Sbjct: 241 LITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELA 300
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + A+ + L++ S+ +HAS+I G+R S PK I++H
Sbjct: 301 DLHGKDAALLFSSCFVAHDSTLFTLVKMMPGCEIYSDSGDHASMIQGIRNSRVPKYIFRH 360
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D+ L++ L+ + KI+ + V S+DG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 361 NDVSHLRELLQRSDPSVPKIVAFETVHSVDGAVLPLEELCDVAHEFGAITFVDEVHAWGL 420
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAFG +GGY+A ++ ++ A F+F++++
Sbjct: 421 YGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTRSLMDTVRSYAAGFIFTTSLP 480
Query: 278 PPDVAAAIAAVEILQKSDDLV--KKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V IL+ ++ V ++ N +++ L D G + + I PV + D
Sbjct: 481 PMLLAGALESVRILKSAEGRVVRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAA 540
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E L +NI+ QAI YPTVP G +R+ P+ HT + + ++ K+ G
Sbjct: 541 KNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVG 600
>pir||B31452 5-aminolevulinate synthase (EC 2.3.1.37), hepatic - chicken
>gi|63608|emb|CAA26595.1| (X02827) precursor (aa 1-635)
[Gallus gallus]
Length = 635
Score = 218 bits (549), Expect = 1e-55
Identities = 117/360 (32%), Positives = 202/360 (55%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ K V CSN+YLG++ HP++ A + + +G GAG R I+GT + HV+LE++LA
Sbjct: 234 LITKKEVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLEKELA 293
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+R S PK I++H
Sbjct: 294 DLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDSGNHASMIQGIRNSRVPKHIFRH 353
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D++ L++ L+++ KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 354 NDVNHLRELLKKSDPSTPKIVAFETVHSMDGAVCPLEELCDVAHEHGAITFVDEVHAVGL 413
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAF +GGY++ I+ ++ A F+F++++
Sbjct: 414 YGARGGGIGDRDGVMHKMDIISGTLGKAFACVGGYISSTSALIDTVRSYAAGFIFTTSLP 473
Query: 278 PPDVAAAIAAVEILQKSDDLV--KKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V L+ ++ V ++ N +++ L D G + + I P+ + D
Sbjct: 474 PMLLAGALESVRTLKSAEGQVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPIRVADAA 533
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E +L +++I+ QAI YPTVP G +R+ P+ HT + + ++ K G
Sbjct: 534 KNTEICDKLMSQHSIYVQAINYPTVPRGEELLRIAPTPHHTPQMMSYFLEKLLATWKDVG 593
>sp|P07997|HEM1_CHICK 5-AMINOLEVULINIC ACID SYNTHASE, NONSPECIFIC, MITOCHONDRIAL
PRECURSOR (DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA
SYNTHETASE) (ALAS-H) >gi|66531|pir||SYCHAL
5-aminolevulinate synthase (EC 2.3.1.37) precursor,
nonspecific, mitochondrial - chicken
>gi|763098|emb|CAA27223.1| (X03517) ALA-synthase [Gallus
gallus]
Length = 635
Score = 218 bits (549), Expect = 1e-55
Identities = 117/360 (32%), Positives = 202/360 (55%), Gaps = 2/360 (0%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
++ K V CSN+YLG++ HP++ A + + +G GAG R I+GT + HV+LE++LA
Sbjct: 234 LITKKEVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLEKELA 293
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
++AA+LF S + AN + L + S+ NHAS+I G+R S PK I++H
Sbjct: 294 DLHGKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDSGNHASMIQGIRNSRVPKHIFRH 353
Query: 158 LDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGV 217
D++ L++ L+++ KI+ + V SMDG + PL E+ ++A ++ AI +VD+ H G+
Sbjct: 354 NDVNHLRELLKKSDPSTPKIVAFETVHSMDGAVCPLEELCDVAHEHGAITFVDEVHAVGL 413
Query: 218 LGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMN 277
G+ G GI D + K+D GTL KAF +GGY++ I+ ++ A F+F++++
Sbjct: 414 YGARGGGIGDRDGVMHKMDIISGTLGKAFACVGGYISSTSALIDTVRSYAAGFIFTTSLP 473
Query: 278 PPDVAAAIAAVEILQKSDDLV--KKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEK 335
P +A A+ +V L+ ++ V ++ N +++ L D G + + I P+ + D
Sbjct: 474 PMLLAGALESVRTLKSAEGQVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPIRVADAA 533
Query: 336 LAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
E +L +++I+ QAI YPTVP G +R+ P+ HT + + ++ K G
Sbjct: 534 KNTEICDKLMSQHSIYVQAINYPTVPRGEELLRIAPTPHHTPQMMSYFLEKLLATWKDVG 593
>gb|AAD20810.1| (AF073341) 5-aminolevulinate synthase [Myxine glutinosa]
Length = 661
Score = 218 bits (549), Expect = 1e-55
Identities = 120/356 (33%), Positives = 196/356 (54%), Gaps = 2/356 (0%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
K+V CSN+YLG+ HP++ + + YG GAG R I+GT HV LE++LA
Sbjct: 263 KQVSVWCSNDYLGMGRHPRVINTIMDTLKMYGAGAGGTRNISGTSRFHVALEQELADLHA 322
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
++AA++F S + AN + L + F S+ NHAS+I G+R SG PK I++H D
Sbjct: 323 KDAALVFSSCFVANDSTLFTLAKMLPGCEFYSDAGNHASMIQGIRNSGVPKFIFRHNDAA 382
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
L + L + KI+ + V SMDG + PL E+ +++ +Y AI ++D+ H G+ G+
Sbjct: 383 HLDELLSRSDPSTPKIVAFETVHSMDGAICPLEELCDVSXKYGAITFIDEVHAVGLYGAR 442
Query: 222 GRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDV 281
G GI D L K+D GTL KA+G +GGYVA ++ ++ A F+F++++ P +
Sbjct: 443 GGGIGDREGLMHKMDIISGTLGKAYGCVGGYVASTNTLVDTVRSYAAGFIFTTSLPPMVL 502
Query: 282 AAAIAAVEILQKSDD--LVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQE 339
A A +V++L+ ++ L + N +L++ L D G + + I PV++ + E
Sbjct: 503 AGARESVQVLKSAEGRALRRAHQRNVIYLRQLLMDAGLPVIHCPSHIIPVLVGNAAHNTE 562
Query: 340 FSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGKKTG 395
L +NI+ QAI YPTVP G +R+ + HT + ++ ++ + K G
Sbjct: 563 LCNELMSRHNIYVQAINYPTVPRGEEMLRVVVTPHHTPQMMQYFVEHLTNSWKDIG 618
>pir||T49274 serine palmitoyltransferase-like protein - Arabidopsis thaliana
>gi|7576216|emb|CAB87906.1| (AL132963) serine
palmitoyltransferase-like protein [Arabidopsis thaliana]
Length = 489
Score = 218 bits (549), Expect = 1e-55
Identities = 124/371 (33%), Positives = 208/371 (55%), Gaps = 21/371 (5%)
Query: 43 RVLNMCSNNYLGLAAHPKI-KEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
R LN+ S NYLG + + I ++ + + R AGT +H ELE+ +AK+
Sbjct: 101 RCLNLGSYNYLGFGSFDEYCTPRVIESLKKFSASTCSSRVDAGTTSVHAELEDCVAKYVG 160
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+ AA++F GY N I L+ KG G+ +S+ LNH SI++G R SGA +++H
Sbjct: 161 QPAAVIFGMGYATNSAIIPVLIGKG--GLIISDSLNHTSIVNGARGSGATIRVFQHNTPG 218
Query: 162 DLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDA 212
L+K L+E ++ KK I+V +G++SM+G++ LPEIV + ++Y A VY+D+A
Sbjct: 219 HLEKVLKEQIAEGQPRTHRPWKKIIVVVEGIYSMEGEICHLPEIVSICKKYKAYVYLDEA 278
Query: 213 HGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFL 271
H G +G GRG+ + + VD MGT +K+FG GGY+AG ++ I+YLK + L
Sbjct: 279 HSIGAIGKTGRGVCELLGVDTSDVDIMMGTFTKSFGSCGGYIAGSKDLIQYLKHQCPAHL 338
Query: 272 FSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYD-LGNTKH 324
++++++ P I+A++++ D + ++ +N++F + L+ +G++ LG+
Sbjct: 339 YATSISTPSATQIISAIKVILGEDGSNRGAQKLARIRENSNFFRAELQKMGFEVLGDNDS 398
Query: 325 PITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
P+ P+MLY+ FSR E N+ + +P PL AR R+ SA+H++EDL +
Sbjct: 399 PVMPIMLYNPAKIPAFSRECLRE-NLAVVVVGFPATPLLLARARICISASHSREDLIKAL 457
Query: 385 DAFEDLGKKTG 395
G TG
Sbjct: 458 QVISKAGDLTG 468
>pir||F70701 probable bioF2 protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1552587|emb|CAB02417.1| (Z80233) bioF2
[Mycobacterium tuberculosis]
Length = 771
Score = 217 bits (548), Expect = 1e-55
Identities = 122/344 (35%), Positives = 188/344 (54%), Gaps = 4/344 (1%)
Query: 49 SNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILF 108
+N+YLGLA HP++ EA+ A YG G + GT++LHV LE++LA F + AA+L
Sbjct: 423 TNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNGTLDLHVSLEQELACFLGKPAAVLC 482
Query: 109 QSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLE 168
+GY +NL AISAL G+ + + + LNH S+ D RLSGA +Y+H DMD L + L
Sbjct: 483 STGYQSNLAAISALCESGD--MIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLR 540
Query: 169 ENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDH 228
+ +++ IIV D VFSM+G +A L I ELA+++ VYVD++H GVLG GRG
Sbjct: 541 RTEGRRR-IIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAA 599
Query: 229 FNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAV 288
+ ++D MGT SK+F +GG++AG ++Y++ +FS+++ P AA AA+
Sbjct: 600 LGVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAAL 659
Query: 289 EILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEY 348
+ ++ D ++ ++ GL GY I PV+L + +A RL
Sbjct: 660 RVSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRS- 718
Query: 349 NIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGK 392
++ + P VP + R A H + DL + F L +
Sbjct: 719 GVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRALHVFAGLAE 762
>pir||D82692 8-amino-7-oxononanoate synthase XF1357 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9106357|gb|AAF84166.1|AE003967_10 (AE003967)
8-amino-7-oxononanoate synthase [Xylella fastidiosa]
Length = 401
Score = 217 bits (546), Expect = 2e-55
Identities = 133/363 (36%), Positives = 202/363 (55%), Gaps = 4/363 (1%)
Query: 25 TIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAG 84
T R ++ G + +NG ++ CSN+YLGLA H +I A A G+GA A I G
Sbjct: 25 TRRTIERRNGVRLEINGSWLVEFCSNDYLGLAQHFEIIAALQDAAARDGIGATASHLICG 84
Query: 85 TMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDG 144
+H LE +LA++ A+LF +G+ ANL ALL K E+ I + + LNHAS+ID
Sbjct: 85 HHAIHKALEYELAEWLGYPRALLFGNGFTANLAVQQALLTK-ENDICVQDRLNHASLIDA 143
Query: 145 MRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYD 204
RL+G Y HLD+D +L +N + ++ TDG+FSMDGD+APL + +A
Sbjct: 144 TRLAGCRLRRYPHLDVDGAAHQL-KNAPEGAAMLATDGIFSMDGDIAPLRALSLVARTQQ 202
Query: 205 AIVYVDDAHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYL 263
A++YVDDAHG GV G G G V L ++V ++ TLSKA G G + G I++L
Sbjct: 203 ALMYVDDAHGIGVTGPQGSGCVAAAWLSVEEVPLQLVTLSKALGGYGAALLGSATLIQHL 262
Query: 264 KQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTK 323
+ ARP+++++A+ P AAA+ A+ I ++ + ++L + ++ R G ++ +++
Sbjct: 263 AETARPYIYTTALPPAQAAAALTAIRIARRDEWRRQRLQELVERFRENSRRHGLEIMDSE 322
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLV 383
PI P+ DE S L E AI PTVP G +R+R+ SA HT E + +
Sbjct: 323 TPIQPLQCGDETTTMAMSAAL-EREGFLVNAIRPPTVPEGKSRLRVTLSALHTTEQIDTL 381
Query: 384 IDA 386
+ A
Sbjct: 382 VQA 384
>emb|CAA45489.1| (X64131) acyl-transferase [Sinorhizobium meliloti]
Length = 446
Score = 215 bits (543), Expect = 5e-55
Identities = 125/343 (36%), Positives = 194/343 (56%), Gaps = 7/343 (2%)
Query: 30 QSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELH 89
Q+A G +++G++++N S +YLGL H + E A I +G+ A A R +AG H
Sbjct: 61 QTAAGATTMIDGRKLINFASYDYLGLNRHAHVLERARETIAGFGISASASRLVAGERPQH 120
Query: 90 VELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSG 149
VELEEK+A+F +AA+ F SGY N+ AIS L+ G + + +E H S + G++LSG
Sbjct: 121 VELEEKIAQFYGVDAAVCFVSGYLTNVAAISCLM--GPKDLVIHDEFIHNSALAGIKLSG 178
Query: 150 APKVIYKHLDMDDLKKKLEE-NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVY 208
A + +KH D DL+ L D ++ +++ +G++SMDGD+A LP +++L +Y +
Sbjct: 179 ATRRFFKHNDTADLEHVLRTVAGDYRRILVIVEGIYSMDGDVANLPALLKLRAEYGFWLM 238
Query: 209 VDDAHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRA 267
VD+AH GVLG HGRG+ +HF +VD MGTLSK GGY+AG LK A
Sbjct: 239 VDEAHSLGVLGRHGRGLAEHFGADPHEVDIWMGTLSKTTSSCGGYIAGSAALAAVLKASA 298
Query: 268 RPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLG-NTKHPI 326
F++S + P A+A+A+++IL + + N K ++ G D G + +
Sbjct: 299 GGFVYSVGLAPVLAASAVASLDILASEPERTAAVRRNGSLFLKLAKEAGLDTGLSGGFSV 358
Query: 327 TPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRL 369
PV++ D A + S L N+ I++P VP G AR+R+
Sbjct: 359 VPVIVGDSLRAVQLSNDLLAAGNVL--PIIHPAVPEGQARLRV 399
>pir||T48458 8-amino-7-oxononanoate synthase-like protein - Arabidopsis thaliana
>gi|7406466|emb|CAB85568.1| (AL162875)
8-amino-7-oxononanoate synthase-like protein
[Arabidopsis thaliana]
Length = 469
Score = 215 bits (541), Expect = 9e-55
Identities = 133/362 (36%), Positives = 206/362 (56%), Gaps = 33/362 (9%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
K++L N+YLGL++HP I AA A+ +YG+G I G H LE LA+ KK
Sbjct: 102 KKLLLFSGNDYLGLSSHPTISNAAANAVKEYGMGPKGSALICGYTTYHRLLESSLAQLKK 161
Query: 102 REAAILFQSGYNANL------GAISALLR------KGEDGIFLSEELNHASIIDGMRLS- 148
+E ++ +G+ AN+ G++++LL K E S+ LNHASIIDG+RL+
Sbjct: 162 KEDCLVCPTGFAANMAAMVAIGSVASLLAASGKPLKNEKVAIFSDALNHASIIDGVRLAE 221
Query: 149 ---GAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDA 205
+Y+H D+ + K K +K++VTD +FSMDGD AP+ E+ +L ++Y
Sbjct: 222 RQGNVEVFVYRHCDISNCKMK--------RKVVVTDSLFSMDGDFAPMEELSQLRKKYGF 273
Query: 206 IVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQ 265
++ +DDAHG V G +G G+ + FN VD +GTLSKA G GG++A ++ + ++
Sbjct: 274 LLVIDDAHGTFVCGENGGGVAEEFNCEADVDLCVGTLSKAAGCHGGFIACSKKWKQLIQS 333
Query: 266 RARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDL-GYDLGNTKH 324
R R F+FS+A+ P AAA AAV + +K K +W+ K ++L G D+ +
Sbjct: 334 RGRSFIFSTAIPVPMAAAAYAAVVVARKEIWRRKAIWERV----KEFKELSGVDISS--- 386
Query: 325 PITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
PI +++ +++ A + SR L + AI PTVP + R+R+ SAAHT ED+K +I
Sbjct: 387 PIISLVVGNQEKALKASRYLLKS-GFHVMAIRPPTVPPNSCRLRVTLSAAHTTEDVKKLI 445
Query: 385 DA 386
A
Sbjct: 446 TA 447
>gb|AAD20808.1| (AF073339) 5-aminolevulinate synthase [Sepia officinalis]
Length = 603
Score = 214 bits (540), Expect = 1e-54
Identities = 132/386 (34%), Positives = 210/386 (54%), Gaps = 10/386 (2%)
Query: 9 WIKEELEELKKKGLY-VTIRVLQSAQG-PWVV----VNGKRVLNMCSNNYLGLAAHPKIK 62
+ ++E+E+ K+ Y V +VL+ PW +N K + CSN+Y+G++ HP +
Sbjct: 187 FFEKEIEKKKEDHSYRVFKKVLRKGNKFPWAEEYSNINKKDITVWCSNDYVGMSWHPLVT 246
Query: 63 EAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISAL 122
+ A+ YG GAG R I+G LH LE++LA ++EAA+LF S Y AN + L
Sbjct: 247 NSVQEALHKYGAGAGGTRNISGNSPLHESLEKELASLHQKEAALLFTSCYVANDTTLCTL 306
Query: 123 LRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDG 182
+ S+ NHAS+I G+R S APK I+ H D L++ L + KI+ +
Sbjct: 307 GKHLPGVQIFSDAGNHASMIQGIRNSRAPKHIFNHNDPLHLEELLRKADPNIPKIVALET 366
Query: 183 VFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTL 242
V SM G + PL E+ ++A +Y A+ +VD+ H G+ G +G GI + + K+D GTL
Sbjct: 367 VHSMTGAVCPLEELCDVAHKYGALTFVDEVHAVGLXGENGAGIGERDKVLHKMDMITGTL 426
Query: 243 SKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDD---LVK 299
KAFG +GGY+A I+ ++ A F+F++++ P +A A A+ ++ KSD+ L +
Sbjct: 427 GKAFGNMGGYMASTTLTIDMIRSYASGFIFTTSLPPTTLAGATTAIRVM-KSDEGKQLRR 485
Query: 300 KLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPT 359
K N +L+ L +G I P+ + D KL+ L ++NI+ QAI YPT
Sbjct: 486 KHQSNVKYLRDCLLTVGIPAVLCPSHIIPIHVGDPKLSTSICNDLLIKHNIYVQAINYPT 545
Query: 360 VPLGTARIRLEPSAAHTKEDLKLVID 385
V G ++R+ + HTKE + +D
Sbjct: 546 VARGEEKLRVAATPHHTKEMMDHFVD 571
>gb|AAD20805.1| (AF073336) 5-aminolevulinate synthase [Limulus polyphemus]
Length = 570
Score = 214 bits (539), Expect = 2e-54
Identities = 122/377 (32%), Positives = 208/377 (54%), Gaps = 7/377 (1%)
Query: 8 DWIKEELEELKKKGLYVTIRVLQSAQGPWVVV----NGKRVLNM-CSNNYLGLAAHPKIK 62
D+ ++++ + KK Y + + G + + +G + + CSN+YLG++ HP++K
Sbjct: 131 DFFQDQIAKKKKDHSYRIFKKVNRIAGGFPLAQEHTDGNHPITVWCSNDYLGMSRHPEVK 190
Query: 63 EAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISAL 122
A I A+ +G GAG R I+G H LE++LA+ +EAA+LF S + AN + L
Sbjct: 191 RAVIEAVEAHGCGAGGTRNISGNSPFHELLEKELAQLHNKEAALLFTSCFVANDSTLFTL 250
Query: 123 LRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDG 182
+ S+ NHAS+I G+R SG K I+ H + + L++ L + KI+ +
Sbjct: 251 AKSLPGCHIFSDAGNHASMIQGIRNSGVSKHIFHHNNPEHLEELLSKVDISIPKIVAFET 310
Query: 183 VFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTL 242
V SM G + PL ++ ++A +Y AI +VD+ H G+ G HG GI + + K+D GTL
Sbjct: 311 VHSMTGAVCPLEKMCDVAHKYGAITFVDEVHAVGLYGEHGGGIGEXDGVMHKMDIISGTL 370
Query: 243 SKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDD--LVKK 300
KAFG IGGY+A ++ ++ A F+F++++ P + A+ ++++L+ + L +K
Sbjct: 371 GKAFGNIGGYIASTLPLVDTVRSYATGFIFTTSLPPTVLKGALTSIQVLKSEEGRMLREK 430
Query: 301 LWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTV 360
DN +L+K L + G + + I PV + D + + S L + + QAI YPTV
Sbjct: 431 HQDNVRYLRKTLMNAGIPVVHCPSHIIPVHVGDPWYSTKVSNELISMHGHYVQAINYPTV 490
Query: 361 PLGTARIRLEPSAAHTK 377
P G ++R+ P+ HT+
Sbjct: 491 PRGEEKLRIAPTPFHTR 507
>gb|AAF21252.1|AF053456_1 (AF053456) serine palmitoyl Co-A transferase subunit 2 [Pichia
ciferrii]
Length = 562
Score = 213 bits (537), Expect = 3e-54
Identities = 132/372 (35%), Positives = 210/372 (55%), Gaps = 22/372 (5%)
Query: 45 LNMCSNNYLGLAAHPKIKEAAIRAILDY-GVGAGAVRTIAGTMELHVELEEKLAKFKKRE 103
LN+ S NYLG A A ILDY GVG+G R + GT +LH++ E+ +AKF ++
Sbjct: 153 LNLSSYNYLGFAQSEGACTQAALEILDYYGVGSGGPRNVIGTTDLHLKTEKTIAKFIGKD 212
Query: 104 AAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDL 163
+ILF GY N S+LL K + +S+ELNHASI G+RLSG+ + H +M L
Sbjct: 213 DSILFSMGYATNASLFSSLLDK--KSLVISDELNHASIRTGVRLSGSTVKTFPHNNMIAL 270
Query: 164 KKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHG 214
+K L E ++ KK I+ +G++SM+G +A LP ++EL +Y ++VD+AH
Sbjct: 271 EKILREQISQGQPRSHRPWKKIIVAVEGLYSMEGTMANLPALIELRRKYKFNLFVDEAHS 330
Query: 215 EGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G +G GRG+ D+F + VD MGTL+K+FG GGY+AG ++ I LK ++
Sbjct: 331 IGAIGPSGRGVCDYFGIDPSNVDLLMGTLTKSFGAAGGYIAGSQQIINRLKLNINSQNYA 390
Query: 274 SAMNPPDVAAAIAAVEILQ------KSDDLVKKLWDNTHFLQKGLRDLGYDL-GNTKHPI 326
++ P +A I+++ I+ + + ++++ N+ +L+ GL+ LG+ + G P+
Sbjct: 391 ESIPAPVLAQIISSLNIISGDLNPGEGSERLERIAFNSRYLRLGLQRLGFIVYGVDDSPV 450
Query: 327 TPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
P++L+ FSR LY+ I + YP PL ++ +RL A+ KED+ ++
Sbjct: 451 IPLLLFAPAKMPAFSRMLYQG-KISVVVVGYPATPLTSSGVRLGVPASLPKEDMDYLLRH 509
Query: 387 FEDLGKKTGFLK 398
+LG K FLK
Sbjct: 510 LSELGDKL-FLK 520
>pir||T25261 probable glycine C-acetyltransferase (EC 2.3.1.29) T25B9.1
[similarity] - Caenorhabditis elegans
>gi|3880184|emb|CAA94376.1| (Z70311) Similarity to Human
5-aminolevulinic acid synthase (SW:HEMO_HUMAN), contains
similarity to Pfam domain: PF00222 (Aminotransferases
class-II), Score=158.1, E-value=5e-44, N=1~cDNA EST
yk436f11.3 comes from this gene~cDNA EST yk436f11.5
comes fr>
Length = 366
Score = 212 bits (534), Expect = 6e-54
Identities = 133/389 (34%), Positives = 201/389 (51%), Gaps = 64/389 (16%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNG--KRVLNMCSNNYLGLAAHPKIKEAAIR 67
+K EL +K G + T RV+Q QG V V G K V+N C+NNYLGL++HP++ A +
Sbjct: 33 LKNELAGIKNAGTFKTERVIQGRQGVLVKVTGSDKPVINFCANNYLGLSSHPEVIAAGQK 92
Query: 68 AILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGE 127
A+ +G G +VR I GT ++H ELE+K+A+F E IL+ + ++AN ++
Sbjct: 93 ALETHGAGLSSVRFICGTQDIHKELEQKIAQFHGTEDTILYAACFDANDSRFRLIV---T 149
Query: 128 DGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMD 187
DG+F SMD
Sbjct: 150 DGVF-----------------------------------------------------SMD 156
Query: 188 GDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAF- 246
GD+APL +I LAE+Y+A++++D+ H G G GRG + + + D TL KA
Sbjct: 157 GDVAPLGDITSLAEKYNALLFIDECHATGFFGKTGRGTAE--AVGGRPDVINSTLGKALG 214
Query: 247 GVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTH 306
G +GGY GP+ I+ L+QR+RP+LFS+++ P V ++I ++L + L N
Sbjct: 215 GSMGGYTTGPKPLIDLLRQRSRPYLFSNSLAPSIVGSSIKVFDLLMNDSSFIGSLQTNVS 274
Query: 307 FLQKGLRDLGYD-LGN-TKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGT 364
+K + G+ LGN HPI PV+L D KLA + L + I+ +P VP G
Sbjct: 275 HFRKSMAANGFTILGNDPTHPICPVLLGDAKLAATMADELL-KMGIYVIGFSFPVVPKGK 333
Query: 365 ARIRLEPSAAHTKEDLKLVIDAFEDLGKK 393
ARIR++ SAAH+K+ + +I+AF +GKK
Sbjct: 334 ARIRVQISAAHSKQHIDQLIEAFATVGKK 362
>pir||T25126 serine C-palmitoyltransferase (EC 2.3.1.50) T22G5.5 [similarity] -
Caenorhabditis elegans >gi|3880048|emb|CAB03390.1|
(Z81127) contains similarity to Pfam domain: PF00222
(Aminotransferases class-II), Score=228.5,
E-value=3.1e-65, N=1~cDNA EST EMBL:M88913 comes from
this gene~cDNA EST yk182h2.5 comes from this gene~cDNA
EST yk243a9.5 comes from this gene~cDNA EST yk34>
Length = 527
Score = 212 bits (533), Expect = 8e-54
Identities = 124/370 (33%), Positives = 209/370 (55%), Gaps = 21/370 (5%)
Query: 44 VLNMCSNNYLGLAAHPKI-KEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKR 102
V+N+ S NYLG + + EAA I YG+ G R G H +E +A++
Sbjct: 151 VINLGSYNYLGFSHRSGVCAEAAAAHIDKYGINCGGSRQEIGNHVAHKSVESTIAQYLNV 210
Query: 103 EAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDD 162
E AI+F G+ N I +L+ KG + LS+ LNHAS++ G RLSGA V+++H D D
Sbjct: 211 EDAIVFPMGFATNSMNIPSLVDKGS--LILSDRLNHASLVTGCRLSGAHTVVFRHNDASD 268
Query: 163 LKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAH 213
++KL + + K +I+ +G++SM+G + LP + + ++Y+ +++D+AH
Sbjct: 269 CERKLRDALCGVSPKTGEKYNKVLIIIEGIYSMEGTIVNLPAFIAVKKKYNCYLFLDEAH 328
Query: 214 GEGVLGSHGRGIVDHFNLHDK-VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLF 272
G +G GRG+ +++ + + +D MGTL+K+F GGY+ G ++ I+++++ + +
Sbjct: 329 SIGAVGPSGRGVAEYWGCNPRDIDIMMGTLTKSFASAGGYMGGSKKVIDHIRRYSAGTCY 388
Query: 273 SSAMNPPDVAAAIAAVEILQKSD--DLVK----KLWDNTHFLQKGLRDLGYDL-GNTKHP 325
M+PP +A AV I+ D D+ + +L +N+ + +K LR G+ + GN P
Sbjct: 389 GVTMSPPLIAQVERAVLIMSGKDGTDIGRQKAIQLLENSRYFRKELRKRGFLVYGNNDSP 448
Query: 326 ITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVID 385
+ P+M + EFSRR+ ++NI A+ YP PL AR+R SA HTKE L +++
Sbjct: 449 VVPLMTFYITKVVEFSRRML-KHNIGIVAVGYPATPLLEARVRFCLSADHTKEHLDYILE 507
Query: 386 AFEDLGKKTG 395
A E +G +TG
Sbjct: 508 AVEQVGMETG 517
>dbj|BAA97234.1| (AB025633) serine palmitoyltransferase [Arabidopsis thaliana]
Length = 489
Score = 210 bits (528), Expect = 3e-53
Identities = 120/371 (32%), Positives = 206/371 (55%), Gaps = 21/371 (5%)
Query: 43 RVLNMCSNNYLGLAAHPKI-KEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
R LN+ S NYLG + + I ++ + + R AGT +H ELEE + +F
Sbjct: 101 RCLNLGSYNYLGFGSFDEYCTPRVIESLKKFSASTCSSRVDAGTTSVHAELEECVTRFVG 160
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+ AA++F GY N I L+ KG G+ +S+ LNH+SI++G R SGA +++H
Sbjct: 161 KPAAVVFGMGYATNSAIIPVLIGKG--GLIISDSLNHSSIVNGARGSGATIRVFQHNTPS 218
Query: 162 DLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDA 212
L++ L E ++ KK I+V +G++SM+G++ LPE+V + ++Y A VY+D+A
Sbjct: 219 HLERVLREQIAEGQPRTHRPWKKIIVVVEGIYSMEGEICHLPEVVAICKKYKAYVYLDEA 278
Query: 213 HGEGVLGSHGRGIVDHFNLHD-KVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFL 271
H G +G G+GI + + VD MGT +K+FG GGY+AG +E I+YLK + L
Sbjct: 279 HSIGAIGKTGKGICELLGVDTADVDVMMGTFTKSFGSCGGYIAGSKELIQYLKHQCPAHL 338
Query: 272 FSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYD-LGNTKH 324
+++++ P I+A++++ D + ++ +N++F + L+ +G++ LG+
Sbjct: 339 YATSIPTPSAQQIISAIKVILGEDGSNRGAQKLARIRENSNFFRAELQKMGFEVLGDNDS 398
Query: 325 PITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
P+ P+MLY+ FSR + + + +P PL AR R+ SA+H++EDL +
Sbjct: 399 PVMPIMLYNPAKIPAFSRECLRQ-KVAVVVVGFPATPLLLARARICISASHSREDLIRAL 457
Query: 385 DAFEDLGKKTG 395
+G +G
Sbjct: 458 KVISKVGDLSG 468
>dbj|BAB03231.1| (AB046384) serine palmitoyltransferase [Arabidopsis thaliana]
Length = 489
Score = 210 bits (528), Expect = 3e-53
Identities = 120/371 (32%), Positives = 206/371 (55%), Gaps = 21/371 (5%)
Query: 43 RVLNMCSNNYLGLAAHPKI-KEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
R LN+ S NYLG + + I ++ + + R AGT +H ELEE + +F
Sbjct: 101 RCLNLGSYNYLGFGSFDEYCTPRVIESLKKFSASTCSSRVDAGTTSVHAELEECVTRFVG 160
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+ AA++F GY N I L+ KG G+ +S+ LNH+SI++G R SGA +++H
Sbjct: 161 KPAAVVFGMGYATNSAIIPVLIGKG--GLIISDSLNHSSIVNGARGSGATIRVFQHNTPS 218
Query: 162 DLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDA 212
L++ L E ++ KK I+V +G++SM+G++ LPE+V + ++Y A VY+D+A
Sbjct: 219 HLERVLREQIAEGQPRTHRPWKKIIVVVEGIYSMEGEICHLPEVVAICKKYKAYVYLDEA 278
Query: 213 HGEGVLGSHGRGIVDHFNLHD-KVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFL 271
H G +G G+GI + + VD MGT +K+FG GGY+AG +E I+YLK + L
Sbjct: 279 HSIGAIGKTGKGICELLGVDTADVDVMMGTFTKSFGSCGGYIAGSKELIQYLKHQCPAHL 338
Query: 272 FSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYD-LGNTKH 324
+++++ P I+A++++ D + ++ +N++F + L+ +G++ LG+
Sbjct: 339 YATSIPTPSAQQIISAIKVILGEDGSNRGAQKLARIRENSNFFRAELQKMGFEVLGDNDS 398
Query: 325 PITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
P+ P+MLY+ FSR + + + +P PL AR R+ SA+H++EDL +
Sbjct: 399 PVMPIMLYNPAKIPAFSRECLRQ-KVAVVVVGFPATPLLLARARICISASHSREDLIRAL 457
Query: 385 DAFEDLGKKTG 395
+G +G
Sbjct: 458 KVISKVGDLSG 468
>sp|Q09925|LCB2_SCHPO SERINE PALMITOYLTRANSFERASE 2 (LONG CHAIN BASE BIOSYNTHESIS PROTEIN
2) (SPT 2) >gi|2130481|pir||JC5183 serine
C-palmitoyltransferase (EC 2.3.1.50) chain Lcb2 -
fission yeast (Schizosaccharomyces pombe)
>gi|1001947|gb|AAC49534.1| (U15645) serine
palmitoyltransferase [Schizosaccharomyces pombe]
>gi|2414613|emb|CAB16362.1| (Z99259) serine
palmitoyltransferase 2 [Schizosaccharomyces pombe]
Length = 603
Score = 208 bits (524), Expect = 9e-53
Identities = 124/367 (33%), Positives = 204/367 (54%), Gaps = 21/367 (5%)
Query: 45 LNMCSNNYLGLA-AHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKRE 103
LN+ S NYLG A +H A+ YG+ + I GT LH E+EE A F +
Sbjct: 190 LNVSSYNYLGFAQSHGPCATKVEEAMQKYGLSTCSSNAICGTYGLHKEVEELTANFVGKP 249
Query: 104 AAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDL 163
AA++F G++ N S L+ G + +S+ELNH SI G RLSGA +YKH DM DL
Sbjct: 250 AALVFSQGFSTNATVFSTLMCPGS--LIISDELNHTSIRFGARLSGANIRVYKHNDMTDL 307
Query: 164 KKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHG 214
++ L E ++ K ++V +G++SM+G+ LP++VEL +Y +++D+AH
Sbjct: 308 ERVLREVISQGQPRTHRPYSKILVVIEGLYSMEGNFCDLPKVVELKNRYKFYLFIDEAHS 367
Query: 215 EGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G +G G GI D+F + D VD MGT +K+FG GGY++ I L+ ++++
Sbjct: 368 IGAIGPRGGGICDYFGISTDHVDILMGTFTKSFGAAGGYISATPNIINKLRVTNPGYVYA 427
Query: 274 SAMNPPDVAAAIAA-VEILQKSD-----DLVKKLWDNTHFLQKGLRDLGYDL-GNTKHPI 326
+M+P +A ++ +EI+ S + +++L N+ +++ GL+ LG+ + GN P+
Sbjct: 428 ESMSPAVLAQIKSSFLEIMDNSPTSAGLERIERLAFNSRYIRLGLKRLGFIIFGNDDSPV 487
Query: 327 TPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
P++LY+ FS + + I + YP PL T+R+R SA+H K D+ + A
Sbjct: 488 VPLLLYNPGKINAFSHEMLKR-GIAVVVVGYPACPLLTSRVRFCFSASHNKADMDYFLRA 546
Query: 387 FEDLGKK 393
+++G+K
Sbjct: 547 CDEVGEK 553
>gb|AAD21558.1| (AF088896) aminolevulinic acid synthase [Zymomonas mobilis]
Length = 345
Score = 208 bits (524), Expect = 9e-53
Identities = 114/332 (34%), Positives = 186/332 (55%), Gaps = 1/332 (0%)
Query: 55 LAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNA 114
+ +P + A A+ + G G+G R I+GT H ELE +LA++ +EAA+ F SG+ +
Sbjct: 1 MGQNPDVISAMEEALNNVGAGSGGTRNISGTTHYHSELEAELAEWHGKEAALTFTSGFVS 60
Query: 115 NLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKK 174
N +S + + + S+ELNHAS+I G+R S K IY+H D+ L++ L
Sbjct: 61 NEATLSTIAKVLPGCVIFSDELNHASMIAGIRNSRCEKRIYRHNDLAHLEELLAAENPDL 120
Query: 175 KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDK 234
K+I + V+SM+GD+AP+ I +LA++Y+AI Y+D+ H G+ G G GI D L D+
Sbjct: 121 PKLIAFESVYSMEGDIAPIAAICDLADKYNAITYLDEVHAVGMYGPRGAGIADREGLADR 180
Query: 235 VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKS 294
+ GTL+KA GV+GGY+A + ++ ++ A F+FS+++ P +AA +A++ L+ S
Sbjct: 181 LTIIEGTLAKAIGVMGGYIAADQLIVDVIRSYAPGFIFSTSL-APVLAAGLASIRHLKIS 239
Query: 295 DDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQA 354
+ L++ +D G + T I P+ + D + S L EY + Q
Sbjct: 240 SKERDAQQKHAALLKQMFKDAGLPVMATTTHIVPLFVGDAVKTKRISDILLNEYGAYVQP 299
Query: 355 IVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
I +PTVP GT R+R P H + L+ + D+
Sbjct: 300 INFPTVPRGTERLRFTPGPTHNEAMLRELTDS 331
>gb|AAA91866.1| (M63244) mino levulinate synthase [Mus musculus]
Length = 587
Score = 207 bits (522), Expect = 2e-52
Identities = 112/346 (32%), Positives = 197/346 (56%), Gaps = 2/346 (0%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
K V CSN+YLG++ HP++ +A + ++G GAG R I+GT + HVELE++LA+ +
Sbjct: 189 KDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHQ 248
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+++A+LF S + AN + L + S+ NHAS+I G+R SGA K +++H D
Sbjct: 249 KDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPG 308
Query: 162 DLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSH 221
LKK LE++ K KI+ + V SMDG + PL E+ ++A QY A+ +VD+ H G+ G+
Sbjct: 309 HLKKLLEKSDPKTPKIVAFETVHSMDGAIVPLEELCDVAHQYGALTFVDEVHAVGLYGAG 368
Query: 222 GRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDV 281
+ + + K+D GTL KAFG +GGY+A + ++ ++ A F+F++++ P +
Sbjct: 369 VQVSGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVL 428
Query: 282 AAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQE 339
+ A+ +V +L ++ L + N +++ L D G+ + I P+ + + L +
Sbjct: 429 SGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIWVGNAALNSK 488
Query: 340 FSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVID 385
L +++I+ QAI Y TVP G + P H+ + ++ ++
Sbjct: 489 ICDLLLSKHSIYVQAINYXTVPRGEELLXXAPXPHHSPQMMENFVE 534
>pir||SYCHLE 5-aminolevulinate synthase (EC 2.3.1.37) precursor,
erythroid-specific, mitochondrial - chicken
Length = 513
Score = 206 bits (519), Expect = 3e-52
Identities = 123/345 (35%), Positives = 187/345 (53%), Gaps = 6/345 (1%)
Query: 48 CSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAIL 107
CS++YLGL+ HP + AA A+ +G+GAG R I GT LH LE LA ++ A L
Sbjct: 127 CSSDYLGLSRHPAVLRAARAALDAHGLGAGGTRNIGGTSPLHGALERALALLHRQPRAAL 186
Query: 108 FQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKL 167
F S + AN A+ L R S+ NHAS+I G+R G PK I++H D L++ L
Sbjct: 187 FSSCFAANDTALDTLARILPGCQVYSDAGNHASMIQGIRRRGVPKFIFRHNDPHHLEQLL 246
Query: 168 EENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVD 227
+ KI+ + + SMDG +APL E+ ++A Y A+ +VD+ H G+ G+ G GI +
Sbjct: 247 GRSPPGVPKIVAFESLHSMDGSIAPLEELCDVAHAYGALTFVDEVHAVGLYGARGAGIAE 306
Query: 228 HFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAA 287
+ KVD GTL KA G +GGY+AG E ++ ++ F+F++A+ P A+AA
Sbjct: 307 RDGVQHKVDVVSGTLGKALGAVGGYIAGSEALVDAVRSLGPGFIFTTALPPQRGGGALAA 366
Query: 288 VEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHP--ITPVMLYDEKLAQEFSRRLY 345
++++ ++ + H K LR L D G P I PV +D + SR L
Sbjct: 367 LQVVGSAEGAALRRAHQRH--AKHLRVLLRDRGLPALPSHIVPVR-WDAEANTRLSRALL 423
Query: 346 EEYNIFAQAIVYPTVPLG-TARIRLEPSAAHTKEDLKLVIDAFED 389
EE+ ++ QAI +PTVP G +R+ P+ H+ L+ + D +
Sbjct: 424 EEHGLYVQAINHPTVPRGQELLLRIAPTPHHSPPMLENLADKLSE 468
>sp|P18080|HEM0_CHICK 5-AMINOLEVULINIC ACID SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL
PRECURSOR (DELTA-AMINOLEVULINATE SYNTHASE) (DELTA-ALA
SYNTHETASE) (ALAS-E) >gi|517499|gb|AAA20400.1| (M24367)
delta-aminolevulinate synthase [Gallus sp.]
Length = 513
Score = 206 bits (519), Expect = 3e-52
Identities = 123/345 (35%), Positives = 187/345 (53%), Gaps = 6/345 (1%)
Query: 48 CSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAIL 107
CS++YLGL+ HP + AA A+ +G+GAG R I GT LH LE LA ++ A L
Sbjct: 127 CSSDYLGLSRHPAVLRAARAALDAHGLGAGGTRNIGGTSPLHGALERALALLHRQPRAAL 186
Query: 108 FQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKL 167
F S + AN A+ L R S+ NHAS+I G+R G PK I++H D L++ L
Sbjct: 187 FSSCFAANDTALDTLARILPGCQVYSDAGNHASMIQGIRRRGVPKFIFRHNDPHHLEQLL 246
Query: 168 EENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVD 227
+ KI+ + + SMDG +APL E+ ++A Y A+ +VD+ H G+ G+ G GI +
Sbjct: 247 GRSPPGVPKIVAFESLHSMDGSIAPLEELCDVAHAYGALTFVDEVHAVGLYGARGAGIAE 306
Query: 228 HFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAA 287
+ KVD GTL KA G +GGY+AG E ++ ++ F+F++A+ P A+AA
Sbjct: 307 RDGVQHKVDVVSGTLGKALGAVGGYIAGSEALVDAVRSLGPGFIFTTALPPQRGGGALAA 366
Query: 288 VEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHP--ITPVMLYDEKLAQEFSRRLY 345
++++ ++ + H K LR L D G P I PV +D + SR L
Sbjct: 367 LQVVGSAEGAALRRAHQRH--AKHLRVLLRDRGLPALPSHIVPVR-WDAEANTRLSRALL 423
Query: 346 EEYNIFAQAIVYPTVPLG-TARIRLEPSAAHTKEDLKLVIDAFED 389
EE+ ++ QAI +PTVP G +R+ P+ H+ L+ + D +
Sbjct: 424 EEHGLYVQAINHPTVPRGQELLLRIAPTPHHSPPMLENLADKLSE 468
>pir||T49275 serine palmitoyltransferase-like protein - Arabidopsis thaliana
(fragment) >gi|7576217|emb|CAB87907.1| (AL132963) serine
palmitoyltransferase-like protein [Arabidopsis thaliana]
Length = 386
Score = 206 bits (519), Expect = 3e-52
Identities = 124/367 (33%), Positives = 205/367 (55%), Gaps = 20/367 (5%)
Query: 43 RVLNMCSNNYLGLAAHPKI-KEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
R L++ S NYLG + I ++ + + AGT +H ELEE +AKF
Sbjct: 1 RCLSLGSYNYLGFCPFDEYCTPRVIESLKKFSASTCSSCVDAGTTAVHGELEECVAKFVG 60
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
+ AA++F GY N IS L+ KG G+ +S+ LNH SII+G R SGA +++H +
Sbjct: 61 KPAAVVFGMGYLTNSAIISVLIGKG--GLIISDSLNHTSIINGARGSGATIRVFQH---N 115
Query: 162 DLKKKLEENKDK-----KKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEG 216
LK+ + E + + KK I+V +G++SM+G++ LPEIV + +Y A VY+D+AH G
Sbjct: 116 ILKEHIIEGQPRTHRPWKKIIVVVEGIYSMEGEICDLPEIVSVCSEYKAYVYLDEAHSIG 175
Query: 217 VLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSA 275
+G GRG+ + + +VD MGT +K+ G GGY+AG ++ ++YLKQ L++++
Sbjct: 176 AIGKTGRGVCELLGVDTTEVDIMMGTFTKSLGSCGGYIAGSKDLVQYLKQHYPAHLYATS 235
Query: 276 MNPPDVAAAIAAVEIL------QKSDDLVKKLWDNTHFLQKGLRDLGYD-LGNTKHPITP 328
++ P I+A++++ + + + ++ +N++F + L+ +G+ LG PI P
Sbjct: 236 ISTPAAQQVISAIKVIFGVDGSNRGELKLARIRENSNFFRAELQKMGFKVLGVYDSPIMP 295
Query: 329 VMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFE 388
+MLY+ FSR E N+ + +P +PL AR R+ SA+H +EDL +
Sbjct: 296 IMLYNPAKIAAFSRECLRE-NLAIVVVSFPPIPLLLARARICNSASHLREDLIKALQVIS 354
Query: 389 DLGKKTG 395
G TG
Sbjct: 355 RAGDLTG 361
>pir||T34918 polyketide synthase - Streptomyces coelicolor
>gi|2808753|emb|CAA16183.1| (AL021409) polyketide
synthase [Streptomyces coelicolor A3(2)]
Length = 2297
Score = 204 bits (514), Expect = 1e-51
Identities = 124/386 (32%), Positives = 204/386 (52%), Gaps = 11/386 (2%)
Query: 8 DW-----IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIK 62
DW ++ L + + G R + V+G +V+N + NYL L+ HP+++
Sbjct: 1912 DWAEYAELQGRLRQTRTSGSNPYGRTHEGFNSALATVDGTKVVNFAAFNYLALSHHPRVR 1971
Query: 63 EAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISAL 122
+AA A+ YG A A + G LH ELE ++A+F EAAI+F G+ N+ + L
Sbjct: 1972 QAAKDAVDRYGTSASATPLLFGETPLHHELEAEIARFIGTEAAIVFAGGHATNVATVGHL 2031
Query: 123 LRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENK-DKKKKIIVTD 181
G + + + + H S + G LSGA + + H D L + L + ++ ++V +
Sbjct: 2032 F--GPEDLVVHDAWIHDSTVRGCILSGARRRSFPHNDWAALDRILTGARASHRRALVVIE 2089
Query: 182 GVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDK-VDFEMG 240
G +S DGD+ LP +E+ +++ A++ +D+AH GVLG GRG+ +H+ VD MG
Sbjct: 2090 GAYSQDGDIPDLPRFIEVKKRHGAMLMIDEAHSIGVLGRTGRGVGEHYGTDPADVDLWMG 2149
Query: 241 TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKK 300
TLSKA G +GGY+A IEYLK A +FS+ ++P + AAA+ A+ ++Q + V +
Sbjct: 2150 TLSKALGSLGGYIAARRPIIEYLKFTAPLHIFSTGISPANAAAALEALRVVQDEPERVAR 2209
Query: 301 LWDNTHFLQKGLRDLGYDLGNTK-HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPT 359
+ + F + G R G D+G ++ + PV+ D + S L E + I YP
Sbjct: 2210 VQELAEFFRAGARARGLDVGVSRLSAVIPVITGDWEKTMALSNSLLER-GVNVMPIGYPA 2268
Query: 360 VPLGTARIRLEPSAAHTKEDLKLVID 385
VP R+R +A H++ DL+ +D
Sbjct: 2269 VPRDQCRLRFFINADHSEADLEHSLD 2294
>gb|AAA53669.1| (L33931) ScS1p [Saccharomyces cerevisiae]
Length = 561
Score = 202 bits (509), Expect = 5e-51
Identities = 121/367 (32%), Positives = 205/367 (54%), Gaps = 21/367 (5%)
Query: 45 LNMCSNNYLGLA-AHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKRE 103
+N+ S NYLG A + + +AA+ ++ Y + +G R GT +LH++ E+ +A+F +E
Sbjct: 158 MNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKE 217
Query: 104 AAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDL 163
A++F GY N +A L K + +S+ELNH SI G+RLSGA +KH DM L
Sbjct: 218 DALVFSMGYGTNANLFNAFLDK--KCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGL 275
Query: 164 KKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHG 214
+K + E N+ KK +I +G+FSM+G L LP++VEL ++Y +++D+AH
Sbjct: 276 EKLIREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHS 335
Query: 215 EGVLGSHGRGIVDHFNLHDK-VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G +G GRG+ + F + K VD MGT +K+FG GGY+A + I+ L+ +S
Sbjct: 336 IGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYS 395
Query: 274 SAMNPPDVAAAIAAVEILQ------KSDDLVKKLWDNTHFLQKGLRDLGYDL-GNTKHPI 326
+M P +A I++++ + + + ++++ N+ +L+ L+ LG+ + G P+
Sbjct: 396 ESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALKRLGFIVYGVADSPV 455
Query: 327 TPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
P++LY FSR + + I + YP PL +R+R SA+ TKED+ ++
Sbjct: 456 IPLLLYCPSKMPAFSRMMLQR-RIAVVVVAYPATPLIESRVRFCMSASLTKEDIDYLLRH 514
Query: 387 FEDLGKK 393
++G K
Sbjct: 515 VSEVGDK 521
>pir||JC5181 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 chain - yeast
(Saccharomyces cerevisiae)
Length = 561
Score = 202 bits (509), Expect = 5e-51
Identities = 121/367 (32%), Positives = 205/367 (54%), Gaps = 21/367 (5%)
Query: 45 LNMCSNNYLGLA-AHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKRE 103
+N+ S NYLG A + + +AA+ ++ Y + +G R GT +LH++ E+ +A+F +E
Sbjct: 158 MNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKE 217
Query: 104 AAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDL 163
A++F GY N +A L K + +S+ELNH SI G+RLSGA +KH DM L
Sbjct: 218 DALVFSMGYGTNANLFNAFLDK--KCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGL 275
Query: 164 KKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHG 214
+K + E N+ KK +I +G+FSM+G L LP++VEL ++Y +++D+AH
Sbjct: 276 EKLIREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHS 335
Query: 215 EGVLGSHGRGIVDHFNLHDK-VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G +G GRG+ + F + K VD MGT +K+FG GGY+A + I+ L+ +S
Sbjct: 336 IGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYS 395
Query: 274 SAMNPPDVAAAIAAVEILQ------KSDDLVKKLWDNTHFLQKGLRDLGYDL-GNTKHPI 326
+M P +A I++++ + + + ++++ N+ +L+ L+ LG+ + G P+
Sbjct: 396 ESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPV 455
Query: 327 TPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
P++LY FSR + + I + YP PL +R+R SA+ TKED+ ++
Sbjct: 456 IPLLLYCPSKMPAFSRMMLQR-RIAVVVVAYPATPLVESRVRFCMSASLTKEDIDYLLRH 514
Query: 387 FEDLGKK 393
++G K
Sbjct: 515 VSEVGDK 521
>gi|6320267 Probable component of serine palmitoyltransferase, which catalyzes
the first step in biosynthesis of long-chain
sphingolipids; Lcb2p [Saccharomyces cerevisiae]
>gi|729923|sp|P40970|LCB2_YEAST SERINE
PALMITOYLTRANSFERASE 2 (LONG CHAIN BASE BIOSYNTHESIS
PROTEIN 2) (SPT 2) >gi|1078090|pir||S54046 serine
C-palmitoyltransferase (EC 2.3.1.50) chain LCB2 - yeast
(Saccharomyces cerevisiae) >gi|536871|gb|AAA34740.1|
(M95669) serine palmitoyl transferase [Saccharomyces
cerevisiae] >gi|706828|emb|CAA58978.1| (X84162) subunit
of serine palmitoyl transferase [Saccharomyces
cerevisiae] >gi|798913|emb|CAA89091.1| (Z49209) Lcb2p
[Saccharomyces cerevisiae] >gi|1431513|emb|CAA98880.1|
(Z74358) ORF YDR062w [Saccharomyces cerevisiae]
Length = 561
Score = 202 bits (508), Expect = 7e-51
Identities = 121/367 (32%), Positives = 205/367 (54%), Gaps = 21/367 (5%)
Query: 45 LNMCSNNYLGLA-AHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKRE 103
+N+ S NYLG A + + +AA+ ++ Y + +G R GT +LH++ E+ +A+F +E
Sbjct: 158 MNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKE 217
Query: 104 AAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDL 163
A++F GY N +A L K + +S+ELNH SI G+RLSGA +KH DM L
Sbjct: 218 DALVFSMGYGTNANLFNAFLDK--KCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGL 275
Query: 164 KKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHG 214
+K + E N+ KK +I +G+FSM+G L LP++VEL ++Y +++D+AH
Sbjct: 276 EKLIREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHS 335
Query: 215 EGVLGSHGRGIVDHFNLHDK-VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G +G GRG+ + F + K VD MGT +K+FG GGY+A + I+ L+ +S
Sbjct: 336 IGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYS 395
Query: 274 SAMNPPDVAAAIAAVEILQ------KSDDLVKKLWDNTHFLQKGLRDLGYDL-GNTKHPI 326
+M P +A I++++ + + + ++++ N+ +L+ L+ LG+ + G P+
Sbjct: 396 ESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPV 455
Query: 327 TPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDA 386
P++LY FSR + + I + YP PL +R+R SA+ TKED+ ++
Sbjct: 456 IPLLLYCPSKMPAFSRMMLQR-RIAVVVVAYPATPLIESRVRFCMSASLTKEDIDYLLRH 514
Query: 387 FEDLGKK 393
++G K
Sbjct: 515 VSEVGDK 521
>sp|P48241|LCB2_KLULA SERINE PALMITOYLTRANSFERASE 2 (LONG CHAIN BASE BIOSYNTHESIS PROTEIN
2) (SPT 2) >gi|2144263|pir||JC5182 serine
C-palmitoyltransferase (EC 2.3.1.50) Lcb2 chain - Yeast
(Kluyveromyces lactis) >gi|1001949|gb|AAC49535.1|
(U15646) serine palmitoyltransferase [Kluyveromyces
lactis]
Length = 562
Score = 196 bits (492), Expect = 5e-49
Identities = 131/376 (34%), Positives = 200/376 (52%), Gaps = 30/376 (7%)
Query: 45 LNMCSNNYLGLA-AHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKRE 103
LN+ S NYLG A + + AA+ A YGV +G RT GT +LHV E+ +A+F +E
Sbjct: 157 LNLSSYNYLGFAQSEGQCTTAALEATDKYGVYSGVPRTRIGTTDLHVMTEKYVAQFVGKE 216
Query: 104 AAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDL 163
AILF GY N ++ L + +S+ LNH SI G+RLSGA +KH DM L
Sbjct: 217 DAILFSMGYGTNANFFNSFL--DSKCLVISDSLNHTSIRTGVRLSGAAVKTFKHNDMRAL 274
Query: 164 KKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHG 214
+K + E ++ KK II +G++SM+G +A LP++VEL ++Y ++VD+AH
Sbjct: 275 EKLIREQIVQGQSKTHRPWKKIIICVEGLYSMEGTMANLPKLVELKKKYKCYLFVDEAHS 334
Query: 215 EGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G +G GRG+ D F + +D MGTL+K+FG GGY+A A +++ R R L +
Sbjct: 335 IGAMGPSGRGVCDFFGIPCSDIDIMMGTLTKSFGAAGGYIA----ADKWIIDRFRLDLTT 390
Query: 274 SAMNPPDVAAAIAAVEILQKS----------DDLVKKLWDNTHFLQKGLRDLGYDL-GNT 322
P A +A + K+ + ++++ N +L+ L+ LG+ + G
Sbjct: 391 PHYGEPTPAPVLAQIASSLKTITGDINPGEGQERLQRIAFNARYLRLALQRLGFIVYGIA 450
Query: 323 KHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKL 382
P+ P++LY FSR + + I + YP PL R+R SAA TKED+
Sbjct: 451 DSPVIPMLLYAPSKMPAFSRMMLQR-KIAVVVVAYPATPLIELRVRFCVSAALTKEDIDY 509
Query: 383 VIDAFEDLGKKTGFLK 398
++ ++G K FLK
Sbjct: 510 LLQHINEVGDKL-FLK 524
>sp|P12998|BIOF_ECOLI 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|66535|pir||SYECKP 8-amino-7-oxononanoate synthase
(EC 2.3.1.47) - Escherichia coli >gi|5821886|pdb|1BS0|A
Chain A, Plp-Dependent Acyl-Coa Synthase
>gi|145426|gb|AAA23516.1| (J04423) 7-keto-8-amino
pelargonic acid synthetase [Escherichia coli]
>gi|1786993|gb|AAC73863.1| (AE000180)
8-amino-7-oxononanoate synthase [Escherichia coli K12]
Length = 384
Score = 194 bits (489), Expect = 1e-48
Identities = 123/360 (34%), Positives = 205/360 (56%), Gaps = 8/360 (2%)
Query: 34 GPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELE 93
G W+V + ++ LN SN+YLGL+ HP+I A + +G+G+G ++G +H LE
Sbjct: 31 GRWLVADDRQYLNFSSNDYLGLSHHPQIIRAWQQGAEQFGIGSGGSGHVSGYSVVHQALE 90
Query: 94 EKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKV 153
E+LA++ A+LF SG+ AN I+A++ K ED I ++ L+HAS+++ LS +
Sbjct: 91 EELAEWLGYSRALLFISGFAANQAVIAAMMAK-EDRI-AADRLSHASLLEAASLSPSQLR 148
Query: 154 IYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAH 213
+ H D+ L + L + ++++VT+GVFSMDGD APL EI ++ +Q++ + VDDAH
Sbjct: 149 RFAHNDVTHLARLL-ASPCPGQQMVVTEGVFSMDGDSAPLAEIQQVTQQHNGWLMVDDAH 207
Query: 214 GEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFS 273
G GV+G GRG + K + + T K FGV G V +YL Q AR ++S
Sbjct: 208 GTGVIGEQGRG--SCWLQKVKPELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYS 265
Query: 274 SAMNPPDVAAAIAAVEILQ--KSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVML 331
++M P A A++ +++ + D +KL + G++DL + L ++ I P+++
Sbjct: 266 TSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSCSAIQPLIV 325
Query: 332 YDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLG 391
D A + + +L ++ + AI PTVP GTAR+RL +AAH +D+ +++ G
Sbjct: 326 GDNSRALQLAEKLRQQ-GCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHGNG 384
>dbj|BAA83721.1| (AB017359) serine palmitoyl transferase LCB2 subunit [Drosophila
melanogaster]
Length = 597
Score = 193 bits (486), Expect = 3e-48
Identities = 123/372 (33%), Positives = 202/372 (54%), Gaps = 22/372 (5%)
Query: 43 RVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
R LN+ S NYLG AA + + + + G+ + R G E ELE A++
Sbjct: 214 RCLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFG 273
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
E AI+F G+ N + +LL G + + +S+E NHASII G+RLSGA ++KH +M
Sbjct: 274 VEDAIVFGMGFATNALNLPSLL--GPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMR 331
Query: 162 DLKKKLEEN----KDKK------KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
DL++ L + KK K +I+ +G+FSM+G + LPE++ L ++Y A +Y+D+
Sbjct: 332 DLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYLYLDE 391
Query: 212 AHGEGVLGSHGRGIVDHFNLHDK-VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G +GS GRG+ D+FN+ K VD MGT +K+FG GGY+AG ++ I++L+ +
Sbjct: 392 AHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAH 451
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSDDL------VKKLWDNTHFLQKGLRDLG-YDLGNTK 323
++++++PP + +++ + D + +L NT + ++ L LG G+
Sbjct: 452 CYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHED 511
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLV 383
P+ P+++Y R L + I A +P P+ RIR SAAHTKE L
Sbjct: 512 SPVVPMLVYLFSKIGAVVRTLTTRH-IAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFA 570
Query: 384 IDAFEDLGKKTG 395
++A +++ G
Sbjct: 571 LEAIDEIADDLG 582
>gb|AAF44946.1|AE003406_151 (AE003416) symbol=lace; synonym=BG:DS01845.3; cDNA=method:''sim4'',
score:''1000.0'', desc:''LD17449 Drosophila melanogaster
embryo, full length mRNA sequence from BDGP'';
match=method:''BLASTX'', version:''2.0a19MP-WashU
[05-Feb-1998] [Build sol2.5-ul>
>gi|7298232|gb|AAF53465.1| (AE003647) lace gene product
[Drosophila melanogaster]
Length = 597
Score = 193 bits (486), Expect = 3e-48
Identities = 123/372 (33%), Positives = 202/372 (54%), Gaps = 22/372 (5%)
Query: 43 RVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
R LN+ S NYLG AA + + + + G+ + R G E ELE A++
Sbjct: 214 RCLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFG 273
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
E AI+F G+ N + +LL G + + +S+E NHASII G+RLSGA ++KH +M
Sbjct: 274 VEDAIVFGMGFATNALNLPSLL--GPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMR 331
Query: 162 DLKKKLEEN----KDKK------KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
DL++ L + KK K +I+ +G+FSM+G + LPE++ L ++Y A +Y+D+
Sbjct: 332 DLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYLYLDE 391
Query: 212 AHGEGVLGSHGRGIVDHFNLHDK-VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G +GS GRG+ D+FN+ K VD MGT +K+FG GGY+AG ++ I++L+ +
Sbjct: 392 AHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAH 451
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSDDL------VKKLWDNTHFLQKGLRDLG-YDLGNTK 323
++++++PP + +++ + D + +L NT + ++ L LG G+
Sbjct: 452 CYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHED 511
Query: 324 HPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLV 383
P+ P+++Y R L + I A +P P+ RIR SAAHTKE L
Sbjct: 512 SPVVPMLVYLFSKIGAVVRTLTTRH-IAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFA 570
Query: 384 IDAFEDLGKKTG 395
++A +++ G
Sbjct: 571 LEAIDEIADDLG 582
>sp|P44422|BIOF_HAEIN 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|1073804|pir||D64129 probable 8-amino-7-oxononanoate
synthase (EC 2.3.1.47) - Haemophilus influenzae (strain
Rd KW20) >gi|1574397|gb|AAC23202.1| (U32830)
8-amino-7-oxononanoate synthase (bioF) [Haemophilus
influenzae Rd]
Length = 380
Score = 191 bits (481), Expect = 1e-47
Identities = 129/382 (33%), Positives = 216/382 (55%), Gaps = 15/382 (3%)
Query: 7 LDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAI 66
+D K++LE+L K Y +I L QG ++ +++LNM SN+YLGLA++ ++++ +
Sbjct: 1 MDAFKQQLEQLSAKNQYRSIPDLVH-QGRYITRENRKMLNMSSNDYLGLASNENLRQSFL 59
Query: 67 RAILDYGVG-----AGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISA 121
+ YG + + R + G ++ +LEE +A+ +RE+A+LF SGY+AN+G + A
Sbjct: 60 Q---QYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANIGILPA 116
Query: 122 LLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDK-KKKIIVT 180
L + L+++L HAS+IDG+RLS Y+H D + LK LE+N K + IVT
Sbjct: 117 LTTT--KSLILADKLVHASMIDGIRLSQCEFFRYRHNDYEHLKNLLEKNVGKFDRTFIVT 174
Query: 181 DGVFSMDGDLAPLPEIVELAEQY-DAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEM 239
+ VFSMDGD+A L ++V+L +Q+ + +YVD+AH GV G +G GI + N+ +D +
Sbjct: 175 ESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAVGVYGQNGLGIAERANVIADIDLLV 234
Query: 240 GTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVK 299
GT KA +G YV + E L + RP +FS+A+ P +VA E L +
Sbjct: 235 GTFGKALASMGAYVVCDQILKECLINQMRPLIFSTALPPFNVAWTHFIFERLPQLSKERT 294
Query: 300 KLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPT 359
L + FL++ + + + ++ I P +L + + ++ L +E + I PT
Sbjct: 295 HLEQLSAFLRQEV-EHRTQIMPSQTCIVPYILGENEATLAKAKDL-QEQGYYCLPIRPPT 352
Query: 360 VPLGTARIRLEPSAAHTKEDLK 381
VP T+RIRL +A T ++++
Sbjct: 353 VPKNTSRIRLSLTADMTADEVR 374
>sp|Q47829|BIOF_ERWHE 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|1399514|gb|AAB03272.1| (U50183)
7-keto-8-aminopelargonic acid synthetase [Erwinia
herbicola]
Length = 385
Score = 190 bits (478), Expect = 2e-47
Identities = 125/370 (33%), Positives = 193/370 (51%), Gaps = 8/370 (2%)
Query: 25 TIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAG 84
T RV++ G W+ V R N SN+YLGL+ HP I A + YGVG+G ++G
Sbjct: 22 TRRVVEQGAGRWLTVGDSRYCNFSSNDYLGLSQHPAIVRAWQQGAEQYGVGSGGSGHVSG 81
Query: 85 TMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDG 144
H LE +LA++ A+LF SG+ AN I+AL G++ ++++L+HAS+++
Sbjct: 82 YTRAHYALESELAEWLGYPRALLFISGFAANQAVIAAL--TGKEDRIVADKLSHASLLEA 139
Query: 145 MRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYD 204
S A + H D+ L L++ D +++ VT+GVFSMDGD APL I E +
Sbjct: 140 ASFSPAQLRRFAHNDVSQLAALLDKPCD-GQQLAVTEGVFSMDGDSAPLAAIAEQVRRAG 198
Query: 205 AIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLK 264
A + VDDAHG V G GRG + K + + T K FGV G V E Y +
Sbjct: 199 AWLLVDDAHGIAVTGHKGRGSCQQQEV--KPELLVVTFGKGFGVSGAAVLCSEAVATYFE 256
Query: 265 QRARPFLFSSAMNPPDVAAAIAAVEIL--QKSDDLVKKLWDNTHFLQKGLRDLGYDLGNT 322
Q AR ++S++M P A AA+ ++ ++ D L + G L + ++
Sbjct: 257 QFARHLIYSTSMPPAQAVALSAALSVIRGEEGDQRRTALAGLIQRFRHGAAALPGRITHS 316
Query: 323 KHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKL 382
+ I P+++ D A + RL ++ + AI PTVP GTAR+RL +AAH ED+
Sbjct: 317 QSAIQPLIVGDNSRALSLAERLRQK-GCWVTAIRPPTVPAGTARLRLTLTAAHQPEDIDR 375
Query: 383 VIDAFEDLGK 392
+++ + G+
Sbjct: 376 LLEVLHESGE 385
>pir||I38873 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 chain - human
(fragment) >gi|1001945|gb|AAC50871.1| (U15555) serine
palmitoyltransferase [Homo sapiens]
Length = 411
Score = 189 bits (474), Expect = 7e-47
Identities = 103/265 (38%), Positives = 164/265 (61%), Gaps = 13/265 (4%)
Query: 42 KRVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
K V+NM S NYLG A + +EAA + + +YG G + R G ++ H ELEE +A+F
Sbjct: 109 KGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFL 168
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
EAA+ + G+ N I AL+ KG + LS+ELNHAS++ G RLSGA I+KH +M
Sbjct: 169 GVEAAMAYGMGFATNSMNIPALVGKG--CLILSDELNHASLVLGARLSGATIRIFKHNNM 226
Query: 161 DDLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
L+K L++ + KK +I+ +G++SM+G + LPE++ L ++Y A +Y+D+
Sbjct: 227 QSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDE 286
Query: 212 AHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G LG GRG+V++F L + VD MGT +K+FG GGY+ G +E I+YL+ +
Sbjct: 287 AHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSA 346
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSD 295
+++++++PP V I +++ + D
Sbjct: 347 VYATSLSPPVVEQIITSMKCIMGQD 371
>pir||PC4253 serine C-palmitoyltransferase (EC 2.3.1.50) Lcb2 chain - human
(fragment)
Length = 371
Score = 189 bits (474), Expect = 7e-47
Identities = 103/265 (38%), Positives = 164/265 (61%), Gaps = 13/265 (4%)
Query: 42 KRVLNMCSNNYLGLAAHP-KIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFK 100
K V+NM S NYLG A + +EAA + + +YG G + R G ++ H ELEE +A+F
Sbjct: 104 KGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFL 163
Query: 101 KREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDM 160
EAA+ + G+ N I AL+ KG + LS+ELNHAS++ G RLSGA I+KH +M
Sbjct: 164 GVEAAMAYGMGFATNSMNIPALVGKG--CLILSDELNHASLVLGARLSGATIRIFKHNNM 221
Query: 161 DDLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDD 211
L+K L++ + KK +I+ +G++SM+G + LPE++ L ++Y A +Y+D+
Sbjct: 222 QSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDE 281
Query: 212 AHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPF 270
AH G LG GRG+V++F L + VD MGT +K+FG GGY+ G +E I+YL+ +
Sbjct: 282 AHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSA 341
Query: 271 LFSSAMNPPDVAAAIAAVEILQKSD 295
+++++++PP V I +++ + D
Sbjct: 342 VYATSLSPPVVEQIITSMKCIMGQD 366
>pir||A82239 8-amino-7-oxononanoate synthase VC1113 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9655584|gb|AAF94272.1|
(AE004192) 8-amino-7-oxononanoate synthase [Vibrio
cholerae]
Length = 384
Score = 188 bits (472), Expect = 1e-46
Identities = 130/385 (33%), Positives = 208/385 (53%), Gaps = 12/385 (3%)
Query: 10 IKEELEELKKKGLYVTIRVL-QSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
I++ L E + L +++L +SAQG ++ + LN SN+YLGLA ++ +A
Sbjct: 9 IEQALNEREHSRLTRRLQLLDRSAQGE-LIQQDRTYLNFSSNDYLGLANDAELVQAWQTG 67
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
+ +G G+GA + G H ELE +L + E A+LF SG++AN + LL K +
Sbjct: 68 LARFGAGSGASPMVTGFSSAHAELEHELCHWLGYERAVLFSSGFSANQALLFTLLEK--E 125
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDG 188
+ L ++LNHAS+++ LS A +KH D + L++ L E + ++VT+GVFSMDG
Sbjct: 126 DLLLQDKLNHASLMEAGMLSPATMKRFKHNDTEHLRQLLHE---QSNSLVVTEGVFSMDG 182
Query: 189 DLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGV 248
D APL +I L +Q A + VDDAHG GVLG G G +H ++ + T KAFG+
Sbjct: 183 DCAPLAQIATLVKQ-RAWLMVDDAHGIGVLGEDGAGSCQAAGIHPEI--LVVTFGKAFGL 239
Query: 249 IGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFL 308
G V +YL Q AR ++S+AM P A A ++Q ++L +
Sbjct: 240 AGAAVLCDAHVGDYLTQFARHHVYSTAMPPAQAHALTHAARMIQSQSWRREQLAELLACF 299
Query: 309 QKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIR 368
+ R++ + T+ PI P +L A S L ++ I+ AI PTVP+G+AR+R
Sbjct: 300 DEQCRNIPGFVA-TQTPIKPWLLGSSDSALSASHEL-KQQGIWVSAIRPPTVPVGSARLR 357
Query: 369 LEPSAAHTKEDLKLVIDAFEDLGKK 393
+ +AAHT+ ++ + + + + +K
Sbjct: 358 ITITAAHTQAQIRRLSEQLKHVMEK 382
>sp|O06621|BIOF_MYCTU 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|7433715|pir||C70540 probable 8-amino-7-oxononanoate
synthase (EC 2.3.1.47) - Mycobacterium tuberculosis
(strain H37RV) >gi|2117268|emb|CAB09068.1| (Z95586) bioF
[Mycobacterium tuberculosis] >gi|2791846|gb|AAB96957.1|
(AF041819) putative 8-amino-7-oxononanoate synthase
[Mycobacterium bovis BCG]
Length = 386
Score = 187 bits (469), Expect = 3e-46
Identities = 120/347 (34%), Positives = 187/347 (53%), Gaps = 10/347 (2%)
Query: 45 LNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREA 104
L++ SN+YLGL+ HP + + ++A+ +G GA R + G +LH + E +LA+F A
Sbjct: 43 LDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAA 102
Query: 105 AILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLK 164
+LF SGY ANLGA+ L G + +S+ +HAS++D RLS A V+ H D+D +
Sbjct: 103 GLLFSSGYTANLGAVVGL--SGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVD 160
Query: 165 KKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRG 224
L ++D+++ ++VTD VFS DG LAP+ E++E+ ++ A++ VD+AHG GV G GRG
Sbjct: 161 AAL-RSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGG-GRG 218
Query: 225 IVDHFNLHDKVDFEM-GTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAA 283
++ L D M TLSKA G GG V GP +L ARPF+F + + P V A
Sbjct: 219 LLYELGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGA 278
Query: 284 AIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRR 343
A AA+ +LQ + + ++ L R G ++ ++ E +
Sbjct: 279 ARAALRVLQAEPWRPQAVLNHAGEL---ARMCGVAAVPDSAMVSVILGEPESAVAAAAAC 335
Query: 344 LYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDL 390
L + + PTVP GT+R+RL A+ +L+L D+
Sbjct: 336 L--DAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDV 380
>emb|CAC01467.1| (AL391014) 8-amino-7-oxononanoate synthase [Streptomyces coelicolor
A3(2)]
Length = 375
Score = 187 bits (469), Expect = 3e-46
Identities = 130/379 (34%), Positives = 190/379 (49%), Gaps = 19/379 (5%)
Query: 9 WIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
WI+E+ ++ GL +RVL+ +L++ SN+YLGLA HP++ E A A
Sbjct: 5 WIEEQDRARREAGL---VRVLRPRPA------SSSLLDLASNDYLGLARHPEVVEGAASA 55
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
+G GA R + GT LH ELE +LA F EAA++F SGY ANL A++AL G
Sbjct: 56 ARTWGGGATGSRLVTGTTALHAELESELAGFCGFEAALVFSSGYAANLAAVTALAPHG-- 113
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDG 188
+ +S+ NHAS+IDG RL+ + H D D ++K L + + V+D VFS+DG
Sbjct: 114 SLVVSDAGNHASLIDGCRLARGTTQVVGHADPDAVRKALATHDG--PAVAVSDTVFSVDG 171
Query: 189 DLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVD-FEMGTLSKAFG 247
D APL + + Y A + VDDAHG GVLG GRG L + D TLSK+ G
Sbjct: 172 DAAPLAALADACRAYGAGLIVDDAHGLGVLGDGGRGAPQGAGLAGRDDVVATVTLSKSLG 231
Query: 248 VIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHF 307
GG V GP + +L AR F+F + + P AA+AA+ +L + + +
Sbjct: 232 AQGGAVLGPARVVAHLVNAARTFIFDTGLAPAAAGAALAALRLLVREPERAARARAVAAE 291
Query: 308 LQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYE--EYNIFAQAIVYPTVPLGTA 365
L + L G D P V+ A+E R + + P+VP G +
Sbjct: 292 LHERLTTAGLD---AVRPDAAVVSVRAPSAEEAVRWAADCRAAGLSVGCFRPPSVPDGIS 348
Query: 366 RIRLEPSAAHTKEDLKLVI 384
R+RL ++E ++ +
Sbjct: 349 RLRLTARGDLSREQIERAV 367
>pir||H81830 8-amino-7-oxononanoate synthase (EC 2.3.1.47) NMA2013 [similarity]
- Neisseria meningitidis (group A strain Z2491)
>gi|7380642|emb|CAB85232.1| (AL162757)
8-amino-7-oxonoanoate synthase [Neisseria meningitidis
Z2491]
Length = 380
Score = 182 bits (458), Expect = 5e-45
Identities = 127/378 (33%), Positives = 207/378 (54%), Gaps = 15/378 (3%)
Query: 11 KEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAIL 70
K++LE+L + Y +I L QG ++ ++LNM SN+YLGLA+ ++ + ++
Sbjct: 5 KQQLEQLGAQNQYRSIPDLIH-QGRYITRENCKMLNMSSNDYLGLASDENLRRSFLQ--- 60
Query: 71 DYGVG-----AGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRK 125
YG + + R + G ++ +LEE +A+ +RE+A+LF SGY+ANLG + AL
Sbjct: 61 QYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPALTTT 120
Query: 126 GEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDK-KKKIIVTDGVF 184
+ L+++ HAS+IDG+RLS Y+H D + LK LE+N K + IVT+ VF
Sbjct: 121 --KSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVF 178
Query: 185 SMDGDLAPLPEIVELAEQY-DAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLS 243
SMDGD+A L ++V+L +Q+ + +YVD+AH GV G +G GI + NL ++D +GT
Sbjct: 179 SMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFG 238
Query: 244 KAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWD 303
KA +G Y + E L + RP +FS+A+ P +VA E L + L
Sbjct: 239 KALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLEQ 298
Query: 304 NTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLG 363
+ FL++ + + ++ I P +L + + L + + I PTVP G
Sbjct: 299 LSAFLRREVAH-RTQIMPSQTCIVPYILGGNEATLAKAEYL-QRQGYYCLPIRPPTVPKG 356
Query: 364 TARIRLEPSAAHTKEDLK 381
T+RIRL +A T ++++
Sbjct: 357 TSRIRLSLTADMTMDEVR 374
>pir||T29503 serine C-palmitoyltransferase (EC 2.3.1.50) F43H9.2 [similarity] -
Caenorhabditis elegans >gi|1226271|gb|AAA92303.1|
(U50307) Similar to serine palmitoyltransferase
[Caenorhabditis elegans]
Length = 558
Score = 180 bits (451), Expect = 3e-44
Identities = 113/367 (30%), Positives = 196/367 (52%), Gaps = 23/367 (6%)
Query: 44 VLNMCSNNYLGLA--AHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
V+N+ S NYLG A A P +++A +I G+ G +LE+ +A+F
Sbjct: 175 VINVGSYNYLGFAQSAGPCAEQSA-SSIDREGLSCCTTVHERGRSVSQAKLEKLVAEFLG 233
Query: 102 REAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMD 161
E AI F G+ N L+ K + +S++ NHAS+I G RLSGA +++H DM+
Sbjct: 234 VEDAICFSMGFATNSMNAPCLVDK--HSLIISDKYNHASLILGCRLSGASTKVFEHNDME 291
Query: 162 DLKKKLEE---------NKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDA 212
L++ L + ++ KK +I+ +G++SM+G + LP I+ L ++Y A +Y+D+A
Sbjct: 292 SLERILRDAIAYGNPKTHRPYKKILIIVEGIYSMEGSICNLPGIIALKKKYQAYLYLDEA 351
Query: 213 HGEGVLGSHGRGIVDHFNLHDK-VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFL 271
H G +G G+G+V+++ K VD MGT +K+FG GGY+AG + +++L+ +
Sbjct: 352 HSIGAMGKTGKGVVEYWGCDPKDVDILMGTFTKSFGAAGGYIAGSKRTVDHLRAASPTGY 411
Query: 272 FSSAMNPPDVAAAIAAVEILQKSD------DLVKKLWDNTHFLQKGLRDLGYDL-GNTKH 324
+SS M+PP ++ I+ D +++L N+H+ + L+ G+ + G+
Sbjct: 412 YSSPMSPPIAQQIYTSMSIIMGKDGTKDGAQRIERLARNSHYFRMKLKQNGFIVYGSNDS 471
Query: 325 PITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVI 384
P+ P+++Y + + R + NI + +P + R+R SAAHTKE L V+
Sbjct: 472 PVVPMLIYFPTMCGFYGREMLAR-NIGCVVVSFPATHMTEGRVRFCISAAHTKEQLDEVL 530
Query: 385 DAFEDLG 391
+ LG
Sbjct: 531 ETVNLLG 537
>pir||C81194 8-amino-7-oxononanoate synthase (EC 2.3.1.47) NMB0472 [similarity]
- Neisseria meningitidis (group B strain MD58)
>gi|7225700|gb|AAF40909.1| (AE002404)
8-amino-7-oxononanoate synthase [Neisseria meningitidis
MC58]
Length = 380
Score = 179 bits (449), Expect = 6e-44
Identities = 125/378 (33%), Positives = 206/378 (54%), Gaps = 15/378 (3%)
Query: 11 KEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAIL 70
K++LE+L + Y +I L QG ++ +++LNM SN+YLGLA+ ++ + ++
Sbjct: 5 KQQLEQLGAQNQYRSIPDLIH-QGRYITRENRKMLNMSSNDYLGLASDENLRRSFLQ--- 60
Query: 71 DYGVG-----AGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRK 125
YG + + R + G ++ +LEE +A+ +RE+A+LF SGY+ANLG + AL
Sbjct: 61 QYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPALTTT 120
Query: 126 GEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDK-KKKIIVTDGVF 184
+ L+++ HAS+IDG+RLS Y+H D + LK LE+N K + IVT+ VF
Sbjct: 121 --KSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVF 178
Query: 185 SMDGDLAPLPEIVELAEQY-DAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLS 243
SMDGD+A L ++V+L +Q+ + +YVD+AH GV G +G GI + NL ++D +GT
Sbjct: 179 SMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFG 238
Query: 244 KAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWD 303
KA +G Y + E L + RP +FS+A+ P +VA E L + L
Sbjct: 239 KALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNVAWTYFIFERLPQFSKERSHLEQ 298
Query: 304 NTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLG 363
+ FL++ + + ++ I P +L + + L + + I TVP
Sbjct: 299 LSAFLRREVAH-RTQIMPSQTCIVPYILGGNEATLAKAEYL-QRQGYYCLPIRPSTVPKN 356
Query: 364 TARIRLEPSAAHTKEDLK 381
T+RIRL +A T ++++
Sbjct: 357 TSRIRLSLTADMTTDEVR 374
>sp|P36570|BIOF_SERMA 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|402533|dbj|BAA04286.1| (D17468)
7-keto-8-aminopelargonic acid synthetase (KAPA
synthetase) [Serratia marcescens]
Length = 382
Score = 178 bits (446), Expect = 1e-43
Identities = 124/383 (32%), Positives = 194/383 (50%), Gaps = 7/383 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAI 69
I++ L E + Y + + G + + + LN N+YLGL+ ++ AA +
Sbjct: 7 IEQALAERRLNAAYRRRQTTEGGNGRQIRLGDRLYLNFSGNDYLGLSQDARVI-AAWQQG 65
Query: 70 LDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDG 129
YGVG G + G H LEE+LA + A+LF S Y AN ++AL++KG+
Sbjct: 66 ARYGVGNGGSGHVTGFSAAHQALEEQLAAWLGYPRALLFIS-YAANQAVLAALMQKGDR- 123
Query: 130 IFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDGVFSMDGD 189
L++ L+HAS+++ + L + +++ VT+G+FSMDGD
Sbjct: 124 -ILADRLSHASLLEAAGAVAGRRAPVPAQSTAGLARICLAKPCDGQRLAVTEGLFSMDGD 182
Query: 190 LAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVI 249
APL E+ L A + VDDAHG GV G GRG + + + + T KAFGV
Sbjct: 183 GAPLAELHRLTRAAGAWLMVDDAHGIGVRGEQGRGSCWQQGV--RPELLVATFGKAFGVS 240
Query: 250 GGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQ 309
G V E EYL Q AR ++S+AM P A AA+ +++ DDL +L DN +
Sbjct: 241 GAAVLCDEATAEYLLQFARHLIYSTAMPPAQACALQAALARIREGDDLRARLQDNIRRFR 300
Query: 310 KGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGTARIRL 369
+G L L ++ I P+++ D + A + + RL E ++ AI PTVP G AR+RL
Sbjct: 301 QGAAPLALTLTDSDTAIQPLLVGDNQRALDLATRL-RECGLWVSAIRPPTVPPGGARLRL 359
Query: 370 EPSAAHTKEDLKLVIDAFEDLGK 392
+AAH +D+ +++ D+ +
Sbjct: 360 LLTAAHQSQDIDRLLEVLNDVSQ 382
>gi|6678125 serine palmitoyltransferase, long chain base subunit 1 [Mus
musculus] >gi|6685592|sp|O35704|LCB1_MOUSE SERINE
PALMITOYLTRANSFERASE 1 (LONG CHAIN BASE BIOSYNTHESIS
PROTEIN 1) (LCB 1) (SERINE-PALMITOYL-COA TRANSFERASE 1)
(SPT 1) >gi|2564282|emb|CAA64897.1| (X95641) serine
C-palmitoyltransferase [Mus musculus]
Length = 473
Score = 175 bits (438), Expect = 1e-42
Identities = 104/305 (34%), Positives = 176/305 (57%), Gaps = 19/305 (6%)
Query: 37 VVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKL 96
+VVNGK +N S N+LGL A+P++K AA ++ YGVG R GT ++H++LEE+L
Sbjct: 93 IVVNGKECVNFASFNFLGLLANPRVKAAAFSSLKKYGVGTCGPRGFYGTFDVHLDLEERL 152
Query: 97 AKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYK 156
AKF K E AI++ G++ AI A ++G D IF+ A I G++ S + ++K
Sbjct: 153 AKFMKTEEAIIYSYGFSTVASAIPAYSKRG-DIIFVDSAACFA-IQKGLQASRSDIKLFK 210
Query: 157 HLDMDDLKKKLEEN--KDKK--------KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAI 206
H D+ DL++ L+E +D+K ++ IV +G++ G + PLPE+V+L +Y A
Sbjct: 211 HNDVADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKAR 270
Query: 207 VYVDDAHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQ 265
++++++ GVLG HGRG+ +H+ + D +D + A +GG+ G +++ +
Sbjct: 271 IFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRL 330
Query: 266 RARPFLFSSAMNPPDVAAAIAAVEILQKSDDL---VKKLWDNTH-FLQ--KGLRDLGYDL 319
+ + FS+++ P AAAI A+ I++++ D+ +KK N H LQ GL+ +G L
Sbjct: 331 SGQGYCFSASLPPLLAAAAIEALNIMEENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESL 390
Query: 320 GNTKH 324
H
Sbjct: 391 SPALH 395
>gb|AAC02264.1| (AF003823) serine palmitoyltransferase LCB1 subunit [Mus musculus]
Length = 473
Score = 174 bits (437), Expect = 1e-42
Identities = 104/305 (34%), Positives = 176/305 (57%), Gaps = 19/305 (6%)
Query: 37 VVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKL 96
+VVNGK +N S N+LGL A+P++K AA ++ YGVG R GT ++H++LEE+L
Sbjct: 93 IVVNGKECVNFASFNFLGLLANPRVKAAAFSSLKKYGVGTCGPRGFYGTFDVHLDLEERL 152
Query: 97 AKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYK 156
AKF K E AI++ G++ AI A ++G D IF+ A I G++ S + ++K
Sbjct: 153 AKFMKTEEAIIYTYGFSTVASAIPAYSKRG-DIIFVDSAACFA-IQKGLQASRSDIKLFK 210
Query: 157 HLDMDDLKKKLEEN--KDKK--------KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAI 206
H D+ DL++ L+E +D+K ++ IV +G++ G + PLPE+V+L +Y A
Sbjct: 211 HNDVADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKAR 270
Query: 207 VYVDDAHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQ 265
++++++ GVLG HGRG+ +H+ + D +D + A +GG+ G +++ +
Sbjct: 271 IFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRL 330
Query: 266 RARPFLFSSAMNPPDVAAAIAAVEILQKSDDL---VKKLWDNTH-FLQ--KGLRDLGYDL 319
+ + FS+++ P AAAI A+ I++++ D+ +KK N H LQ GL+ +G L
Sbjct: 331 SGQGYCFSASLPPLLAAAAIEALNIMEENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESL 390
Query: 320 GNTKH 324
H
Sbjct: 391 SPALH 395
>sp|P45487|BIOF_MYCLE 8-AMINO-7-OXONONANOATE SYNTHASE (AONS) (8-AMINO-7-KETOPELARGONATE
SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE)
(7-KAP SYNTHETASE) (L-ALANINE--PIMELYL COA LIGASE)
>gi|2145621|pir||S72702 8-amino-7-oxononanoate synthase
(EC 2.3.1.47) bioF - Mycobacterium leprae
>gi|466790|gb|AAA17066.1| (U00010)
7-keto-8-aminopelargonic acid synthetase; bioF;
Lepb1170_C2_196 [Mycobacterium leprae]
Length = 385
Score = 171 bits (430), Expect = 9e-42
Identities = 118/347 (34%), Positives = 185/347 (53%), Gaps = 10/347 (2%)
Query: 45 LNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREA 104
L++ SN+YLGL+ HP + + + A+ +G GA R + G LH ELE +LA+F
Sbjct: 39 LDLASNDYLGLSQHPDVIDGGVAALRVWGAGATGSRLVTGDTILHHELECELAEFVGACV 98
Query: 105 AILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLK 164
+LF SGY ANLGA+ L G + +S+ +HAS++D RLS A V+ H D+D +
Sbjct: 99 GLLFSSGYAANLGAVVGL--SGPGSLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVD 156
Query: 165 KKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRG 224
L + +++ ++VT+ VFS DG LAP+ E+ ++ ++ A++ VD+AHG GV G GRG
Sbjct: 157 TAL-RSCHEERAVVVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRGG-GRG 214
Query: 225 IVDHFNLHDKVDFEM-GTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAA 283
+V L D + T+SKA G GG V G +L ARPF+F + + P V A
Sbjct: 215 LVYEVGLAGAPDVVITTTMSKALGSQGGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGA 274
Query: 284 AIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRR 343
A AA++IL+ + + + L K + DL + + V+L D ++A +
Sbjct: 275 ARAALQILKAETWRPEAVLQHARTLAK-ICDLS---ELPQSAVVSVVLGDPEVALAAAIA 330
Query: 344 LYEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDL 390
+ + PTVP GT+R+RL A+ L++ D+
Sbjct: 331 CLDA-GVRVGCFRPPTVPAGTSRLRLTAHASLDSAKLEVARRVLTDV 376
>emb|CAB16844.1| (Z99708) serine C-palmitoyltransferase like protein [Arabidopsis
thaliana] >gi|7270596|emb|CAB80314.1| (AL161589) serine
C-palmitoyltransferase like protein [Arabidopsis
thaliana]
Length = 475
Score = 171 bits (429), Expect = 1e-41
Identities = 97/297 (32%), Positives = 166/297 (55%), Gaps = 9/297 (3%)
Query: 8 DWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIR 67
+W+ E L + + VL+SA GP VNGK V+N S NYLGL H K+ E+
Sbjct: 75 EWVPEPLIPPITEDMKHEPPVLESAAGPHTTVNGKDVVNFASANYLGLIGHEKLLESCTS 134
Query: 68 AILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGE 127
A+ YGVG+ R GT+++H++ E +++KF +IL+ G + I +KG+
Sbjct: 135 ALEKYGVGSCGPRGFYGTIDVHLDCETRISKFLGTPDSILYSYGLSTMFSTIPCFCKKGD 194
Query: 128 DGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKK------KIIVTD 181
+ +++E H I +G++LS + V +KH DM+ L+ LE+ K K + IV +
Sbjct: 195 --VIVADEGVHWGIQNGLQLSRSTIVYFKHNDMESLRITLEKIMTKYKRSKNLRRYIVAE 252
Query: 182 GVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLH-DKVDFEMG 240
V+ G +APL EIV+L E+Y V +D+++ GVLG GRG+ +H ++ +K+D
Sbjct: 253 AVYQNSGQIAPLDEIVKLKEKYRFRVILDESNSFGVLGRSGRGLAEHHSVPIEKIDVVTA 312
Query: 241 TLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDL 297
+ A GG+ G I+Y + + ++FS+++ P +AAI A++++ ++ D+
Sbjct: 313 AMGHALATEGGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVIDQNPDI 369
>sp|O54695|LCB1_CRIGR SERINE PALMITOYLTRANSFERASE 1 (LONG CHAIN BASE BIOSYNTHESIS PROTEIN
1) (LCB 1) (SERINE-PALMITOYL-COA TRANSFERASE 1) (SPT 1)
>gi|2688844|gb|AAC53505.1| (AF004831) serine
palmitoyltransferase LCB1 subunit [Cricetulus griseus]
Length = 473
Score = 171 bits (428), Expect = 2e-41
Identities = 101/325 (31%), Positives = 185/325 (56%), Gaps = 17/325 (5%)
Query: 37 VVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKL 96
+VVNGK +N S N+LGL A+P++K AA+ ++ YGVG R GT ++H++LEE+L
Sbjct: 93 IVVNGKECVNFASFNFLGLLANPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEERL 152
Query: 97 AKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYK 156
AKF + E AI++ G++ AI A ++G D +F+ A I G++ S + ++K
Sbjct: 153 AKFMRTEEAIIYSYGFSTIASAIPAYSKRG-DIVFVDSAACFA-IQKGLQASRSDIKLFK 210
Query: 157 HLDMDDLKKKLEEN--KDKK--------KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAI 206
H D+ DL++ L+E +D+K ++ IV +G++ G + PLPE+V+L +Y A
Sbjct: 211 HNDVADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTVCPLPELVKLKYKYKAR 270
Query: 207 VYVDDAHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQ 265
++++++ GVLG HGRG+ +H+ + D +D + A +GG+ G +++ +
Sbjct: 271 IFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRL 330
Query: 266 RARPFLFSSAMNPPDVAAAIAAVEILQKSDDL---VKKLWDNTHFLQKGLRDLGYDLGNT 322
+ + FS+++ P AAAI A+ I++++ + +KK + H +G+ L +G +
Sbjct: 331 SGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKKKCQHIHKSLQGISGLKV-VGES 389
Query: 323 KHPITPVMLYDEKLAQEFSRRLYEE 347
P + L + ++E +L +E
Sbjct: 390 LSPALHLQLEESTGSREKDVQLLQE 414
>gi|5454084 serine palmitoyltransferase, long chain base subunit 1; serine
palmitoyltransferase subunit I [Homo sapiens]
>gi|6685579|sp|O15269|LCB1_HUMAN SERINE
PALMITOYLTRANSFERASE 1 (LONG CHAIN BASE BIOSYNTHESIS
PROTEIN 1) (LCB 1) (SERINE-PALMITOYL-COA TRANSFERASE 1)
(SPT 1) >gi|2564247|emb|CAA69941.1| (Y08685) serine
palmitoyltransferase, subunit I [Homo sapiens]
Length = 473
Score = 170 bits (427), Expect = 2e-41
Identities = 102/323 (31%), Positives = 181/323 (55%), Gaps = 15/323 (4%)
Query: 38 VVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLA 97
VVNGK +N S N+LGL +P++K AA+ ++ YGVG R GT ++H++LE++LA
Sbjct: 94 VVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLA 153
Query: 98 KFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKH 157
KF K E AI++ G+ AI A ++G D +F+ A I G++ S + ++KH
Sbjct: 154 KFMKTEEAIIYSYGFATIASAIPAYSKRG-DIVFVDRAACFA-IQKGLQASRSDIKLFKH 211
Query: 158 LDMDDLKKKLEEN--KDKK--------KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIV 207
DM DL++ L+E +D+K ++ IV +G++ G + PLPE+V+L +Y A +
Sbjct: 212 NDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARI 271
Query: 208 YVDDAHGEGVLGSHGRGIVDHFNLH-DKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQR 266
+++++ GVLG HGRG+ +H+ ++ D +D + A IGG+ G I++ +
Sbjct: 272 FLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLS 331
Query: 267 ARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLG--YDLGNTKH 324
+ + FS+++ P AAAI A+ I++++ + L + + K L+ + +G +
Sbjct: 332 GQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLS 391
Query: 325 PITPVMLYDEKLAQEFSRRLYEE 347
P + L + ++E RL +E
Sbjct: 392 PAFHLQLEESTGSREQDVRLLQE 414
>gb|AAF58417.1| (AE003819) CG4016 gene product [Drosophila melanogaster]
Length = 468
Score = 165 bits (414), Expect = 7e-40
Identities = 104/331 (31%), Positives = 186/331 (55%), Gaps = 17/331 (5%)
Query: 27 RVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTM 86
RV+QS G + V+G LN+ S+NYLG +I E A +++ YGVG+ R GTM
Sbjct: 79 RVVQSRVGKRIQVDGHDCLNLGSHNYLGFLEDQEILEEACKSLRKYGVGSCGPRGFYGTM 138
Query: 87 ELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMR 146
++H++LE+++AKF E AI++ G++ AI A ++G D IF+ E +N A I G+
Sbjct: 139 DVHLDLEDRIAKFMGLEEAIVYSYGFSTVASAIPAYAKRG-DLIFVDEAVNFA-IQKGLD 196
Query: 147 LSGAPKVIYKHLDMDDLKKKL--EENKDKK--------KKIIVTDGVFSMDGDLAPLPEI 196
S + V +KH D++DL++ L +E +D+K ++ +V +G++ G++ PLP++
Sbjct: 197 ASRSTIVFFKHNDVEDLERLLIEQEKRDQKNPKKAAKTRRFLVAEGIYMNTGEICPLPDL 256
Query: 197 VELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNL-HDKVDFEMGTLSKAFGVIGGYVAG 255
V L ++Y +++D++ G LG G G+ +HFN+ D+VD + + +GG+ G
Sbjct: 257 VALRQKYKLRLFIDESISFGTLGQGGHGVTEHFNVDRDEVDLISAGMEGSMATVGGFCVG 316
Query: 256 PEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFL-QKGLRD 314
E+ + ++FS+++ P AAI+A++ ++ + ++L + L QK LR
Sbjct: 317 SHFIAEHQRLSGLGYIFSASLPPMLTQAAISALDRFEREPQIFEQLQAKSKTLHQKFLRF 376
Query: 315 LGYDLGNTKHPITPVM-LYDEKLAQEFSRRL 344
L + ++PV LY + A+ F + L
Sbjct: 377 SKLTLRGDE--VSPVKHLYLAQPAENFDKEL 405
>pir||G72004 8-amino-7-oxononanoate synthase (EC 2.3.1.47) - Chlamydophila
pneumoniae (strains CWL029 and AR39)
>gi|4377376|gb|AAD19180.1| (AE001684) Oxononanoate
Synthase [Chlamydophila pneumoniae CWL029]
>gi|7189724|gb|AAF38606.1| (AE002240)
8-amino-7-oxononanoate synthase [Chlamydophila
pneumoniae AR39] >gi|8979416|dbj|BAA99250.1| (AP002548)
oxononanoate synthase [Chlamydophila pneumoniae J138]
Length = 382
Score = 160 bits (400), Expect = 3e-38
Identities = 110/351 (31%), Positives = 184/351 (52%), Gaps = 9/351 (2%)
Query: 44 VLNMCSNNYLGLAAHPKIKEAAIRAILDY-GVGAGAVRTIAGTMELHVELEEKLAKFKKR 102
+++ SN+YLG A+ P++++ I + +GA R + G +L +EE+LA +
Sbjct: 29 LIDFTSNDYLGFASSPELRKEYITKLHAIESLGATGSRLLTGHSQLCQRIEEQLAAYHNF 88
Query: 103 EAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDD 162
E+ ++F +GY ANLG + AL +D I L + HASI DG+RLS A + H D++
Sbjct: 89 ESCLIFNTGYTANLGLLYALATD-QDRI-LHDLYIHASIYDGIRLSKAQSFPFNHNDLNH 146
Query: 163 LKKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHG 222
L+K+L + + + + V+S+ G +APL I EL E+Y A + VD+AH GV G G
Sbjct: 147 LEKRLASSH-LGRTFVCVESVYSLHGSVAPLQAISELCERYSAYLIVDEAHAVGVFGDQG 205
Query: 223 RGIVDHFNLHDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVA 282
G+V L DKV + T KA G G +AG +YL RPF++++A P +
Sbjct: 206 EGLVSALGLQDKVLATVYTFGKALGTHGAAIAGSSILKDYLINFCRPFIYTTAQPPHALT 265
Query: 283 AAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDL--GNTKHPITPVMLYDEKLAQEF 340
A A E Q++ + + L H ++ ++LG L NT PI + + A++
Sbjct: 266 AIELAYEHNQRAFNQREHLSALIHHFREKAQNLGLQLMKDNTTTPIQSICVSGSHRARQA 325
Query: 341 SRRLYEE-YNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDL 390
+ ++ Y++ + IV PTV +R+ A +TK ++ ++ E +
Sbjct: 326 ALQIQNSGYDV--RPIVSPTVKQREELLRICLHAFNTKNEIDHLLHTLEQI 374
>pir||F81449 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Cj0306c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6967780|emb|CAB72773.1| (AL139074)
8-amino-7-oxononanoate synthase [Campylobacter jejuni]
Length = 380
Score = 158 bits (396), Expect = 9e-38
Identities = 113/381 (29%), Positives = 209/381 (54%), Gaps = 10/381 (2%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAI 69
+++ L++L++ T+ L+ + +V ++LN+ N+YL LA+ ++K + +
Sbjct: 3 LEKILQDLEQNHNLRTLTPLKH-ENKFVYKQDHKLLNLVGNDYLYLASSKELKAEFLNTL 61
Query: 70 LDYGV--GAGAVRTIAGTMELHVELEEKL-AKFKKREAAILFQSGYNANLGAISALLRKG 126
+ + + + R+++G E++ +LE L KFK +E + F SGY+ N+ I+AL
Sbjct: 62 KEQDLFFSSSSSRSLSGNFEIYEKLESFLKTKFKDKEI-LHFNSGYHLNISCIAALSSVS 120
Query: 127 EDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIV-TDGVFS 185
+ +FL+++ HAS+IDG+RL A + H DM+ L+ ++++ + + IIV ++ +FS
Sbjct: 121 KT-LFLTDKFIHASMIDGLRLGRADFFRFHHKDMNHLESLIQKHYENYENIIVLSEALFS 179
Query: 186 MDGDLAPLPEIVELAEQYDAI-VYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSK 244
MDGD + + EL +YD I +Y+D+AH G G G+V L ++VDF + T K
Sbjct: 180 MDGDFSDFKTLCELKRRYDKIKLYIDEAHSVGCFDEEGLGLVKKLALENEVDFLVFTFGK 239
Query: 245 AFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDN 304
A +G + E+ ++ +AR F++S+A+ P +VA + + +KL
Sbjct: 240 ALASMGACIICDEKYKKFFINKARAFIYSTALPPINVAWTQFIFKKMPYFKKEREKLELL 299
Query: 305 THFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPLGT 364
+ F + L++ + + + I ++L + K A E S++L ++ FA AI PTVP T
Sbjct: 300 STFFKSKLQEKNHIVLGDAY-IICLLLGENKKALEISQKL-QKAGFFAPAIKEPTVPKNT 357
Query: 365 ARIRLEPSAAHTKEDLKLVID 385
ARIR A E+L+ +I+
Sbjct: 358 ARIRFSLHAGLNTEELERIIE 378
>pir||T25557 hypothetical protein C23H3.4 - Caenorhabditis elegans
>gi|1707112|gb|AAB37866.1| (U80453) similar to class-II
of pyridoxal-phosphate dependent aminotransferases
[Caenorhabditis elegans]
Length = 458
Score = 156 bits (391), Expect = 4e-37
Identities = 95/289 (32%), Positives = 161/289 (54%), Gaps = 13/289 (4%)
Query: 37 VVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKL 96
V ++G++ LNM S N+L +I++ A + I YGVG+ R GT+++H++LE++L
Sbjct: 81 VSIDGEKYLNMASTNFLSFIGVKRIEDRAKQTIFKYGVGSCGPRGFYGTVDVHLDLEKEL 140
Query: 97 AKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYK 156
AKF E A+L+ G+ AI A +KG D IF+ E +N A I G++ S + +K
Sbjct: 141 AKFMGCEEAVLYSYGFATVSSAIPAYAKKG-DVIFVDEGVNFA-IQKGLQASRSRVEYFK 198
Query: 157 HLDMDDLKKKL--EENKDKK--------KKIIVTDGVFSMDGDLAPLPEIVELAEQYDAI 206
H DM+ L++ L +E +DKK ++ IV +G++ DL PLP+I+E ++
Sbjct: 199 HNDMEHLERLLLEQEQRDKKDPKKAKSVRRFIVVEGLYVNYADLCPLPKIIEFKWRFKVR 258
Query: 207 VYVDDAHGEGVLGSHGRGIVDHFNL-HDKVDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQ 265
V++D++ GV+G GRG+ +HFN+ + VD M +L A GG+ G + + +
Sbjct: 259 VFIDESWSFGVIGKTGRGVTEHFNVPMEDVDMVMASLENALASTGGFCVGRSYVVGHQRL 318
Query: 266 RARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRD 314
+ FS+++ P AA A+ I+ + V+K+ + QK L+D
Sbjct: 319 SGLGYCFSASLPPLLATAASEAISIIDEEPSRVQKVTEMAINGQKKLQD 367
>pir||S50064 bioF protein - Synechocystis sp. (fragment)
>gi|505682|gb|AAC09513.1| (U10482) putative
8-amino-7-oxononanoate synthase [Synechocystis sp.]
Length = 169
Score = 125 bits (312), Expect = 6e-28
Identities = 60/149 (40%), Positives = 101/149 (67%), Gaps = 2/149 (1%)
Query: 9 WIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
W+ + LE +++ + +++ GP + + G+R++N SN+YLGLA+HP +K AAI+A
Sbjct: 22 WLDDALETIQRAHWHRHPQIITQGPGPEIKLEGQRLVNFASNDYLGLASHPHLKTAAIKA 81
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
I ++G G+ R ++G +LH +LE+ +A++K EAA++F SGY ANLG I+AL+ G+
Sbjct: 82 IAEWGTGSTGSRLLSGHRQLHQDLEQAIARWKGTEAALVFSSGYLANLGTITALV--GKR 139
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKH 157
+ L++E NH+S+ G +LSGA + Y H
Sbjct: 140 DLILADEYNHSSLKRGAQLSGAKVINYDH 168
>pir||T40091 probable serine palmitoyltransferase - fission yeast
(Schizosaccharomyces pombe) >gi|7493374|pir||T39753
probable serine palmitoyltransferase - fission yeast
(Schizosaccharomyces pombe) >gi|3006156|emb|CAA18397.1|
(AL022299) putative serine palmitoyltransferase
[Schizosaccharomyces pombe] >gi|4107321|emb|CAA22662.1|
(AL035077) serine palmitoyltransferase subunit
[Schizosaccharomyces pombe]
Length = 509
Score = 123 bits (306), Expect = 3e-27
Identities = 83/299 (27%), Positives = 154/299 (50%), Gaps = 16/299 (5%)
Query: 8 DWIKE----ELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIKE 63
DW E EL +++K L +I VL+S +++G+ + N S N+L LA + I E
Sbjct: 90 DWKPEPLVAELTDVEKLELK-SIPVLESVHLHTKLIDGRPITNFASFNFLDLAENKHITE 148
Query: 64 AAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALL 123
A+ + + G+GA GT + H+ LE+ +A F E AI++ + I A
Sbjct: 149 CAVATLRECGLGACGPPGFYGTQDKHLRLEKDIASFIGVERAIVYAQSFQTISSVIPAFS 208
Query: 124 RKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEE--------NKDKKK 175
++G+ I + +E + +I G+++S +KH +M DL++ L+E N+ +
Sbjct: 209 KRGD--ILVVDEACNFAIQKGIQISRTTIRYFKHNNMKDLERILQELEDDFVKHNRPLTR 266
Query: 176 KIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNL-HDK 234
+ I+T+G+ GD+ L +IV L ++Y + +D+ G G G+G+ +HF +
Sbjct: 267 RFIITEGISENYGDMVDLTKIVALKKKYKYRLILDETWSFGTCGRTGKGLTEHFGVPPTD 326
Query: 235 VDFEMGTLSKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQK 293
V+ +G+L+ + GG+ AG E +E+ + +++S+A+ AA A+ IL +
Sbjct: 327 VEIIIGSLTTSLAGGGGFCAGSELMVEHQRLSGMAYIYSAALPASLAVAAYEAISILSR 385
>sp|P37419|KBL_SALTY 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (AKB LIGASE) (GLYCINE
ACETYLTRANSFERASE) >gi|459159|gb|AAA59063.1| (U06472)
2-amino-3-ketobutyrate CoA ligase [Salmonella
typhimurium]
Length = 162
Score = 116 bits (289), Expect = 3e-25
Identities = 66/156 (42%), Positives = 95/156 (60%), Gaps = 3/156 (1%)
Query: 10 IKEELEELKKKGLYVTIRVLQSAQGPWVVV-NGKRVLNMCSNNYLGLAAHPKIKEAAIRA 68
+ +LE + +GL+ R++ SAQ + V +G V+N C+NNYLGLA HP++ AA
Sbjct: 9 LTNDLETARAEGLFKEERIITSAQQADITVADGSHVINFCANNYLGLANHPELINAAKAG 68
Query: 69 ILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGED 128
+ +G G +VR I GT + H LE+KLA F E AIL+ S ++AN G LL G +
Sbjct: 69 MDSHGFGMASVRFICGTQDSHKALEQKLASFLGMEDAILYSSCFDANGGLFETLL--GAE 126
Query: 129 GIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLK 164
+S+ LNHASIIDG+RL A + Y + DM +L+
Sbjct: 127 DAIISDALNHASIIDGVRLCKAKRYRYANNDMAELE 162
>pir||H82448 aminotransferase, class II VCA0523 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657929|gb|AAF96426.1|
(AE004383) aminotransferase, class II [Vibrio cholerae]
Length = 389
Score = 115 bits (285), Expect = 9e-25
Identities = 94/387 (24%), Positives = 177/387 (45%), Gaps = 17/387 (4%)
Query: 3 LMGKLDWIKEELEELKKKGLYVTIRVLQSAQGPWVVVNGKRVLNMCSNNYLGLAAHPKIK 62
+ K+D E ++ K G ++ VL P ++ + SN+YL LA HP IK
Sbjct: 10 IQNKIDHYIENYFDINKNGKHL---VLGKQASPDDII-------LQSNDYLALANHPLIK 59
Query: 63 EAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKKREAAILFQSGYNANLGAISAL 122
+++L+ + +E++LAKF + +L QSG+NAN+G + +
Sbjct: 60 ARLAKSLLEEQQSLFMSASFLQNDYDKPMIEKRLAKFTGFDECLLSQSGWNANVGLLQTI 119
Query: 123 LRKGEDGIFLSEELNHASIIDGMRLSGAPKVIYKHLDMDDLKKKLEENKDKKKKIIVTDG 182
+ + +++ + H S+ +G R + A + H + D L+ ++ + IIV D
Sbjct: 120 CQPNTN-VYI-DFFAHMSLWEGARYANAQAHPFMHNNCDHLRMLIQRHGPG---IIVVDS 174
Query: 183 VFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTL 242
++S G +APL E+V +++++ + VD++H G G +G G++ L +V F +L
Sbjct: 175 IYSTLGTIAPLAELVNISKEFGCALLVDESHSLGTHGPNGAGLLAELGLTREVHFMTASL 234
Query: 243 SKAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAMNPPDVAAAIAAVEILQKSDDLVKKLW 302
+K F G + E + + P +FSS + P + A +EI++ +D+ + L
Sbjct: 235 AKTFAYRAGAIWCNNEVNRCVPFISYPAIFSSTLLPYEAAGLETTLEIIESADNRRQHLD 294
Query: 303 DNTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLYEEYNIFAQAIVYPTVPL 362
L+ GL LG + ++ I + DE+ ++ R E +F P
Sbjct: 295 RMARKLRIGLSQLGLTI-RSESQIIGLETGDERNTEKV-RDYLESNGVFGSVFCRPATSK 352
Query: 363 GTARIRLEPSAAHTKEDLKLVIDAFED 389
IRL ++ E + +I+ D
Sbjct: 353 NKNIIRLSLNSDVNDEQIAKIIEVCSD 379
>pir||C81734 8-amino-7-oxononanoate synthase (EC 2.3.1.47) TC0158 [similarity] -
Chlamydia muridarum (strain Nigg)
>gi|7190195|gb|AAF39034.1| (AE002283)
8-amino-7-oxononanoate synthase, putative [Chlamydia
muridarum]
Length = 375
Score = 89.3 bits (218), Expect = 7e-17
Identities = 74/272 (27%), Positives = 126/272 (46%), Gaps = 16/272 (5%)
Query: 39 VNGKRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGV-------GAGAVRTIAGTMELHVE 91
+ G R ++ +N++LG + + +A Y + G G R+I G EL E
Sbjct: 1 MKGSRSIDFITNDFLGFSRLEGLSDAVEARYQRYCISEPYARLGYGGSRSILGPSELLNE 60
Query: 92 LEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGIFLSEELNHASIIDGMRLSGAP 151
LE+ +A F A++ SG+ AN + A L D + E+ H S+ M L
Sbjct: 61 LEQGIAHFHGVAEALVLPSGFVANT-TVCAHLSSAADYVLWDEQA-HISVSYNMALFMPE 118
Query: 152 KV-IYKHLDMDDLKKKLE--ENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVY 208
K ++H D++ L+ L + + K+ I+ V+S G APL +IV LA++Y A +
Sbjct: 119 KQKSFRHNDLNHLESLLASCQKQGFKRVFILVCSVYSFKGSFAPLKQIVALAQRYHAQLI 178
Query: 209 VDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSKAFGVIG-GYVAGPEEAIEYLKQRA 267
VD+AH G+ G GRG ++ V + T KA G +G ++ + +++K+
Sbjct: 179 VDEAHAVGLFGESGRGFCSSIG-YENVYAVLVTFGKALGSVGAALLSSYDRKQDFIKEPM 237
Query: 268 RPFLFSSAMNPPDVAAAIAAVEILQKSDDLVK 299
S+ M P + + A E L K + +
Sbjct: 238 AS--LSTGMPPHSLISIQVAYEFLSKEGEFAR 267
>gb|AAG27130.2|AF155773_3 (AF155773) Fum8p [Gibberella moniliformis]
Length = 839
Score = 80.0 bits (194), Expect = 4e-14
Identities = 70/240 (29%), Positives = 113/240 (46%), Gaps = 21/240 (8%)
Query: 42 KRVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAGTMELHVELEEKLAKFKK 101
+ ++N SNNY G + + I L + +EL + E+LA +
Sbjct: 134 REIVNAGSNNYGGFSRAEHNSASLIETTLRL------LPFNPPPIELASRVNEELATYLG 187
Query: 102 REAAILFQSGYNANLGAISALLRK----GEDGIFLSEELNHASIIDGMRLSG-APKVIYK 156
+A SG++ANL A + + G +FL + +HAS+ G ++ A +K
Sbjct: 188 SKACSTTTSGFSANLLAFTTAAQTAEKLGRHCVFLLDAESHASMFTGAFVNKRATTHRFK 247
Query: 157 HLDMDDLKKKLEENKDKKKKI---IVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAH 213
H D+ DL+ KL K K+ + +G++S+ G ++P P I+ L Y+ + VD+AH
Sbjct: 248 HNDITDLEFKLRILKAKEPDAHVCVAIEGIYSLAGHMSPAPAILALRRVYNFCLLVDEAH 307
Query: 214 GEGVLGSHGRGIVDHFN------LHDKVDFEMGTLSKAFGVIGGYV-AGPEEAIEYLKQR 266
G LG GRG + + +VD GT+SK+ IGG+V A A E +QR
Sbjct: 308 GFMALGKSGRGSFEWWQDCGYDCPLQEVDIMTGTMSKSLCCIGGFVSANGVYAAELERQR 367
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.138 0.394
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 149988205
Number of Sequences: 2977
Number of extensions: 6513828
Number of successful extensions: 18873
Number of sequences better than 1.0e-10: 129
Number of HSP's better than 0.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 18416
Number of HSP's gapped (non-prelim): 136
length of query: 398
length of database: 189,106,746
effective HSP length: 57
effective length of query: 341
effective length of database: 154,992,987
effective search space: 52852608567
effective search space used: 52852608567
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 166 (69.1 bits)