BLASTP 2.0.10 [Aug-26-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= PAB1247 (napA-3) DE:Na+/H+ antiporter (napA-3) (380 letters) Database: ./suso.pep; /banques/blast2/nr.pep 598,487 sequences; 189,106,746 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value pir||C75016 na+/h+ antiporter (napa-3) PAB1247 - Pyrococcus abys... 717 0.0 pir||H71455 probable Na+/H+-exchanging protein - Pyrococcus hori... 631 e-180 pir||F71234 probable Na+/H+-exchanging protein - Pyrococcus hori... 318 7e-86 pir||C75201 na+/h+ antiporter (napa-1) PAB0084 - Pyrococcus abys... 312 6e-84 gb|AAB40041.1| (U17283) putative spore germination apparatus pro... 277 2e-73 gb|AAF91326.1|AF246294_2 (AF246294) GerN [Bacillus cereus] 269 3e-71 sp|P26235|NAPA_ENTHR NA(+)/H(+) ANTIPORTER >gi|282287|pir||A4211... 236 3e-61 emb|CAA51756.1| (X73329) Na/H antiporter homolog [Lactococcus la... 234 1e-60 pir||B71038 probable Na+/H+-exchanging protein - Pyrococcus hori... 234 2e-60 pir||C75176 na+/h+ antiporter (napa-2) PAB0390 - Pyrococcus abys... 230 2e-59 pir||S74414 Na+/H+-exchanging protein sll0689 - Synechocystis sp... 218 8e-56 pir||E70380 Na+/H+-exchanging protein - Aquifex aeolicus >gi|298... 213 3e-54 pir||C75103 na+/h+ antiporter (napa-4) PAB0809 - Pyrococcus abys... 172 5e-42 pir||H71083 probable Na+/H+-exchanging protein - Pyrococcus hori... 172 7e-42 pir||F70155 Na+/H+ antiporter (napA) homolog - Lyme disease spir... 170 2e-41 pir||B64459 Na+/H+-exchanging protein - Methanococcus jannaschii... 169 6e-41 pir||C82955 probable sodium/proton antiporter PA5529 [imported] ... 166 3e-40 dbj|BAB11467.1| (AB005233) Na+/H+ antiporter-like protein [Arabi... 145 6e-34 emb|CAB45049.1| (AL078635) putative integral membrane ion antipo... 142 6e-33 gb|AAK41390.1| Na(+)/H(+) antiporter [Sulfolobus solfataricus] 141 1e-32 pir||T05602 hypothetical protein F9D16.170 - Arabidopsis thalian... 141 1e-32 dbj|BAB02053.1| (AB022219) Na+/H+ exchangeing protein-like [Arab... 140 2e-32 gb|AAF26906.1|AF210843_3 (AF210843) unknown [Sorangium cellulosum] 134 2e-30 pir||S74951 Na+/H+-exchanging protein slr1595 - Synechocystis sp... 134 2e-30 pir||T45912 hypothetical protein F5K20.20 - Arabidopsis thaliana... 132 5e-30 gi|6322367 Yjl094cp [Saccharomyces cerevisiae] >gi|731972|sp|P40... 131 1e-29 gb|AAF24561.1|AC007764_3 (AC007764) F22C12.7 [Arabidopsis thaliana] 131 2e-29 pir||S76532 hypothetical protein - Synechocystis sp. (strain PCC... 127 3e-28 gb|AAD22684.1|AC007063_10 (AC007063) putative Na+/H+ antiporter ... 125 6e-28 dbj|BAB06563.1| (AP001516) Na+/H+ antiporter [Bacillus halodurans] 125 8e-28 pir||T50062 Probable K+/H+-antiporter [imported] - fission yeast... 121 1e-26 gi|11497833 Na+/H+ antiporter (napA-1) [Archaeoglobus fulgidus] ... 120 2e-26 gb|AAF69026.1| (AF182516) unknown [Pseudomonas putida] 114 2e-24 pir||C83496 glutathione-regulated potassium-efflux system protei... 112 6e-24 pir||A69845 Na+/H+ antiporter homolog yjbQ - Bacillus subtilis >... 111 2e-23 pir||D71642 glutathione-regulated potassium-efflux system protei... 111 2e-23 sp|P39830|YBAL_ECOLI HYPOTHETICAL 59.4 KD PROTEIN IN GSK-FSR INT... 106 3e-22 gb|AAK40705.1| Na(+)/H(+) antiporter [Sulfolobus solfataricus] 104 1e-21 pir||C70474 Na+/H+-exchanging protein - Aquifex aeolicus >gi|298... 104 2e-21 pir||B69146 gluthatione-regulated K+/H+ antiporter - Methanobact... 103 4e-21 pir||G75282 probable glutathione-regulated potassium-efflux syst... 102 9e-21 pir||G75431 probable Na+/H+ antiporter - Deinococcus radiodurans... 101 1e-20 pir||G70337 Na+/H+-exchanging protein - Aquifex aeolicus >gi|298... 101 2e-20 sp|P44933|KEFX_HAEIN GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYST... 100 3e-20 dbj|BAA06982.1| (D32253) MagA [Magnetospirillum sp.] 99 6e-20 pir||A81330 probable glutathione-regulated potassium-efflux syst... 99 8e-20 gb|AAD01191.1| (AF003382) KEA1 [Arabidopsis thaliana] 99 1e-19 gb|AAF78418.1|AC009273_24 (AC009273) Identical to K efflux antip... 98 2e-19 pir||E82956 probable potassium efflux transporter PA5518 [import... 97 3e-19 gb|AAC60780.1| (U46859) RosB [Yersinia enterocolitica (type 0:8)] 97 4e-19 pir||G69819 Na+/H+ antiporter homolog yhaU - Bacillus subtilis >... 97 4e-19 pir||B82056 glutathione-regulated potassium-efflux system protei... 96 7e-19 dbj|BAB11240.1| (AB010074) potassium/proton antiporter-like prot... 95 1e-18 sp|P03819|KEFC_ECOLI GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYST... 94 2e-18 pir||G64578 glutathione-regulated potassium-efflux system protei... 94 3e-18 pir||T35370 probable transmembrane transport protein - Streptomy... 93 6e-18 pir||C71934 glutathione-regulated potassium-efflux system protei... 92 8e-18 pir||F82595 glutathione-regulated potassium efflux system protei... 92 8e-18 pir||A72473 probable Na+/H+ antiporter APE2426 - Aeropyrum perni... 92 1e-17 sp|P45522|KEFB_ECOLI GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYST... 90 4e-17 pir||C81997 probable glutathione-regulated potassium-efflux syst... 90 4e-17 pir||B81225 glutathione-regulated potassium-efflux system protei... 90 5e-17 pir||T36239 probable integral membrane efflux protein - Streptom... 89 1e-16 gb|AAA84962.1| (U37008) KefC [Myxococcus xanthus] 88 2e-16 pir||T01227 glutathione-regulated potassium-efflux system protei... 87 3e-16 gb|AAD10158.1| (AC005917) putative potassium/proton antiporter [... 87 3e-16 gb|AAD32281.1|AC006533_5 (AC006533) putative Na+/H+ antiporter [... 87 3e-16 pir||F69201 conserved hypothetical protein MTH760 - Methanobacte... 85 1e-15 pir||T35102 probable transmembrane transport protein - Streptomy... 85 2e-15 gb|AAD30610.1|AC007153_2 (AC007153) similar to Na/H antiporter p... 85 2e-15 pir||F70591 probable kefB protein - Mycobacterium tuberculosis (... 84 3e-15 emb|CAB44437.1| (AJ242913) glutathione-gated K efflux system [Kl... 82 1e-14 emb|CAB76285.1| (AL158057) putative transmembrane transport prot... 82 1e-14 emb|CAC12310.1| (AL445066) Na+/H+ antiporter related protein [Th... 81 2e-14 dbj|BAB10612.1| (AB005243) Na+/H+ antiporter-like protein [Arabi... 80 3e-14 gi|11498844 Na+/H+ antiporter (napA-2) [Archaeoglobus fulgidus] ... 79 1e-13 pir||JC5342 Na+/H+ antiporter cdu2 - Clostridium difficile >gi|1... 76 8e-13 pir||H81265 probable transmembrane transport protein Cj1684c [im... 76 8e-13 pir||H71848 probable na+/h+ antiporter - Helicobacter pylori (st... 75 1e-12 gb|AAK43070.1| Na(+)/H(+) antiporter, putative [Sulfolobus solfa... 74 3e-12 sp|P52071|YPH1_METEX HYPOTHETICAL PROTEIN IN PHAC 3'REGION (ORF1... 73 4e-12 pir||G64667 NA+/H+ antiporter - Helicobacter pylori (strain 2669... 73 4e-12 pir||T51790 hypothetical protein F28D10_120 - Arabidopsis thalia... 73 4e-12 >pir||C75016 na+/h+ antiporter (napa-3) PAB1247 - Pyrococcus abyssi (strain Orsay) >gi|5459083|emb|CAB50569.1| (AJ248288) Na+/H+ antiporter (napA-3) [Pyrococcus abyssi] Length = 380 Score = 717 bits (1831), Expect = 0.0 Identities = 380/380 (100%), Positives = 380/380 (100%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG Sbjct: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL Sbjct: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI Sbjct: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT Sbjct: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 Query: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI Sbjct: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 Query: 301 AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT 360 AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT Sbjct: 301 AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT 360 Query: 361 MVVITTLITPFLLKWAFSKG 380 MVVITTLITPFLLKWAFSKG Sbjct: 361 MVVITTLITPFLLKWAFSKG 380 >pir||H71455 probable Na+/H+-exchanging protein - Pyrococcus horikoshii >gi|3256692|dbj|BAA29375.1| (AP000001) 380aa long hypothetical Na(+)/H(+) antiporter [Pyrococcus horikoshii] Length = 380 Score = 631 bits (1611), Expect = e-180 Identities = 319/380 (83%), Positives = 358/380 (93%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 M V LELAIILV+AK+FGYL V+LGFPAALGQL+GG+IIGPSLL++VEY EVR L+ELG Sbjct: 1 MNVLLELAIILVVAKLFGYLMVKLGFPAALGQLIGGIIIGPSLLNIVEYSQEVRFLAELG 60 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 V++LLFLAGLETDVEEFKHVGLSAFIVA MGVFVPFLLGYL+++++GY SL ALF GG+L Sbjct: 61 VIILLFLAGLETDVEEFKHVGLSAFIVATMGVFVPFLLGYLIAIVYGYRSLAALFLGGIL 120 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 TATSVGLTTSILM+MKKLRTKVGTTILAAAIVDDVLGI+ILT+LVAMSSRG+VE+ DIEI Sbjct: 121 TATSVGLTTSILMEMKKLRTKVGTTILAAAIVDDVLGIIILTILVAMSSRGRVEIFDIEI 180 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 IL EV IFF+LGI IGHP+VKEVL LSE+ITLPETVTTFAIVIML+FAYLAEKFQLAGIT Sbjct: 181 ILAEVIIFFLLGIFIGHPIVKEVLMLSEKITLPETVTTFAIVIMLLFAYLAEKFQLAGIT 240 Query: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 GAYLAGLLVSM+EGS+K+TDK+MTIGYSLFIPIFLVSIGIETDI+VL AGVFA+VYSLI Sbjct: 241 GAYLAGLLVSMSEGSKKVTDKMMTIGYSLFIPIFLVSIGIETDIKVLATAGVFAIVYSLI 300 Query: 301 AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT 360 A++GKI GCGFGALV +FKP EA+QVGIGMIPRMEVALIIANVGLKEGILTRG LA+PVT Sbjct: 301 AIIGKIQGCGFGALVTKFKPAEALQVGIGMIPRMEVALIIANVGLKEGILTRGTLAIPVT 360 Query: 361 MVVITTLITPFLLKWAFSKG 380 MVV+TTL+TPFLLK AFS+G Sbjct: 361 MVVVTTLVTPFLLKLAFSRG 380 >pir||F71234 probable Na+/H+-exchanging protein - Pyrococcus horikoshii >gi|3256522|dbj|BAA29205.1| (AP000001) 375aa long hypothetical Na(+)/H(+) antiporter [Pyrococcus horikoshii] Length = 375 Score = 318 bits (806), Expect = 7e-86 Identities = 168/375 (44%), Positives = 245/375 (64%), Gaps = 7/375 (1%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 ME L LAI+L +AK G++ + P LGQ+L G+++G ++E + + LG Sbjct: 1 METLLLLAILLAVAKFSGWIFEKFNQPIVLGQILAGILMGL----IIERNEIIIEFANLG 56 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSV-LHGYGSLKALFFGGV 119 V+MLLFLAG+E+D+EEFK VG +VA +GV F+ G++V+ +G+ A+ +G V Sbjct: 57 VLMLLFLAGIESDLEEFKKVGKPGILVAGVGVLFAFIFGFIVAYPFFDFGT--AMLYGAV 114 Query: 120 LTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIE 179 +T TSV +T +LM++ KLRT+ GTTILAAA++DDVLGI++LT++++ G V + I Sbjct: 115 MTPTSVSITVKVLMELGKLRTREGTTILAAAVIDDVLGILVLTIVISTLREGSVHYDIIL 174 Query: 180 IILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGI 239 ILLEVA F + + IG +++ +I LPE TTFA+V +++FAYLAE LA I Sbjct: 175 KILLEVAGFLAVFLYIGPVFMEDAFRRLSKIDLPEATTTFAVVFLVLFAYLAEHLNLASI 234 Query: 240 TGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSL 299 GAYL GL + T ++I D + T+GYS+FIP+F V +G+ D R L A VFAL+Y+L Sbjct: 235 LGAYLIGLSIGQTSYKKRIEDHMNTLGYSIFIPLFFVDVGMRIDPRFLLQAKVFALLYAL 294 Query: 300 IAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPV 359 IA++ K+IGCG GA +A F ++++GIGMIPR+ V L + + GI L V + Sbjct: 295 IAMLSKVIGCGLGAYLANFDWKSSLKIGIGMIPRLGVELAMITTAMASGIAGSDVLTVAM 354 Query: 360 TMVVITTLITPFLLK 374 TMV +TTL+TP LLK Sbjct: 355 TMVFLTTLVTPLLLK 369 >pir||C75201 na+/h+ antiporter (napa-1) PAB0084 - Pyrococcus abyssi (strain Orsay) >gi|5457567|emb|CAB49058.1| (AJ248283) Na+/H+ antiporter (napA-1) [Pyrococcus abyssi] Length = 375 Score = 312 bits (790), Expect = 6e-84 Identities = 165/375 (44%), Positives = 245/375 (65%), Gaps = 7/375 (1%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 ME L LA++L +AK+ G++ R P LGQ++ GVI+G ++E + + LG Sbjct: 1 METLLMLALMLAVAKLSGWVFERFNQPIVLGQIIAGVIMGL----LIERNEIIVEFANLG 56 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSV-LHGYGSLKALFFGGV 119 V+MLLFLAGLE+D EEFK VG + +VA +GV FL G+L++ +G+ AL +G + Sbjct: 57 VLMLLFLAGLESDFEEFKRVGRPSILVASVGVLFAFLFGFLIAYPFFDFGT--ALLYGAI 114 Query: 120 LTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIE 179 +T TSV +T +LM++ KLRTK G TILAAA+VDDVLGI+ILT++++M G V + I Sbjct: 115 MTPTSVSITVKVLMELGKLRTKEGATILAAAVVDDVLGILILTIVISMLREGSVHYDVIV 174 Query: 180 IILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGI 239 +LLEVA F + + +G +++ V ++ LPE+ T+FAIV +++FAYLAE LA I Sbjct: 175 EVLLEVAGFLAVFLYLGPVVMENVFRRLSKVDLPESTTSFAIVFLVLFAYLAEHLNLASI 234 Query: 240 TGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSL 299 GAYL GL + T ++I + IGYS+FIP+F V +G+ D R L A FA +Y++ Sbjct: 235 LGAYLIGLSIGQTSYKKRIEGPMNVIGYSIFIPVFFVEVGMRIDPRFLFEAKTFAFLYAV 294 Query: 300 IAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPV 359 A++ K+IGCG GA +++F +I++GIGMIPR+ V L + + + G+ L V + Sbjct: 295 FAMISKVIGCGLGAYLSKFDWRTSIKIGIGMIPRLGVELAMISTAMAAGVAGSDVLTVAM 354 Query: 360 TMVVITTLITPFLLK 374 TMV +TTLITP +L+ Sbjct: 355 TMVFLTTLITPIMLR 369 >gb|AAB40041.1| (U17283) putative spore germination apparatus protein [Bacillus megaterium] >gi|1589214|prf||2210362A grmA gene [Bacillus megaterium] Length = 386 Score = 277 bits (700), Expect = 2e-73 Identities = 152/375 (40%), Positives = 231/375 (61%), Gaps = 2/375 (0%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 ME L LA+IL KI G+LSVRLG P+ LG+LL G+I+GP++L + V SE+G Sbjct: 1 MEFVLSLALILFATKIAGHLSVRLGQPSVLGKLLIGIILGPAVLGWIHNDQFVHYFSEIG 60 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 V++L+FLAGLETD+E+ K +AF VAV+G+ +PF+ G+ V L G G+ +LF G +L Sbjct: 61 VLLLMFLAGLETDLEQLKRNWKAAFAVAVLGIILPFIGGFGVGELFGLGATYSLFIGVLL 120 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 ATSV +T +L DM +L ++ G+TIL AA+VDDVL +V+L ++++ G E + + Sbjct: 121 CATSVSITVQVLKDMNRLNSREGSTILGAAVVDDVLVVVLLAIMISFLGTG--EEVSLGL 178 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 ++ + IFFI +L G +V +VL + + E V + + I + Y A+ +AGI Sbjct: 179 LVGKKLIFFIGAVLAGWLVVPKVLDWLTNLKVTEPVVSIGLAICFGYVYFADLMGMAGII 238 Query: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 GA+ AG+ +S T I K+ I Y++F+P+F VSIG+ + F L+ S+I Sbjct: 239 GAFAAGIAISQTSYRHTIESKVEPIAYAVFVPVFFVSIGLNVSFEGVGDQIGFILLLSVI 298 Query: 301 AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT 360 AV+ K++G GA V F ++ +G GM+ R EVALIIA GL+E +L V Sbjct: 299 AVITKLVGGALGAKVTGFSTRSSLLIGSGMVSRGEVALIIAATGLQESLLLPEYFTSAVI 358 Query: 361 MVVITTLITPFLLKW 375 +++ITTL+ P L+K+ Sbjct: 359 VIIITTLVAPPLIKY 373 >gb|AAF91326.1|AF246294_2 (AF246294) GerN [Bacillus cereus] Length = 387 Score = 269 bits (681), Expect = 3e-71 Identities = 146/376 (38%), Positives = 234/376 (61%), Gaps = 3/376 (0%) Query: 2 EVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGV 61 E F ++A+IL+ K+ G LSVRLG P+ LG+L+ G++IGP++L +E + LS +GV Sbjct: 4 EFFFQIALILLSTKLAGDLSVRLGQPSVLGKLIVGIVIGPAVLGWIENSELLTQLSNVGV 63 Query: 62 VMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLT 121 ++L+F+AGLETD+EE S+ VA+ G+ +PF+ GY+ ++ G A+F G +L Sbjct: 64 ILLMFMAGLETDLEELNANRNSSLAVALGGIILPFVGGYVSGLVMGMEQGNAVFLGLLLC 123 Query: 122 ATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEII 181 ATSV ++ L D+ K++T+ TT+L AA+ DD+L V++ L AMS G +V ++ ++ Sbjct: 124 ATSVSISVQTLRDLGKMKTRESTTMLGAAVFDDIL--VVILLAFAMSFLGTDDV-NLTMV 180 Query: 182 LLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITG 241 +L+ +FF ILIG V ++ + + E++ + A++I FAY E +AGI G Sbjct: 181 ILKKVVFFASIILIGWKGVPAIMRWLSPLRVSESIVSAALIICFSFAYFGELLGIAGIIG 240 Query: 242 AYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIA 301 A+ AG+ +S T ++ K+ I Y++F+P+F VSIG+ + + F L ++IA Sbjct: 241 AFAAGIAISQTNYKHEVEKKVEPIAYAMFVPVFFVSIGMNITFDGIGNQIWFILALTVIA 300 Query: 302 VVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTM 361 V+ K+IGCGFGA + F + +G GM+ R EVALIIA GL G+L + V + Sbjct: 301 VLTKLIGCGFGARMTGFDAKSSAIIGAGMVSRGEVALIIAGTGLSSGLLAQDYFTAIVIV 360 Query: 362 VVITTLITPFLLKWAF 377 V++TT+ITP +LK+ F Sbjct: 361 VILTTMITPPMLKYTF 376 >sp|P26235|NAPA_ENTHR NA(+)/H(+) ANTIPORTER >gi|282287|pir||A42111 Na+/H+-exchanging protein NapA - Enterococcus hirae >gi|148316|gb|AAA24781.1| (M81961) NaH-antiporter protein [Enterococcus hirae] Length = 383 Score = 236 bits (596), Expect = 3e-61 Identities = 128/379 (33%), Positives = 221/379 (57%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 ME L +ILV I ++S R G PA +GQLL GV++G + L V V SE+G Sbjct: 1 MEFIGILCLILVATTIGSHISRRFGIPAVIGQLLVGVLLGQAGLGWVHPNILVHDFSEIG 60 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 V++L+FLAGLE+D+ K VA++G+ P G+L + +A+FFG +L Sbjct: 61 VILLMFLAGLESDLSLLKKYFKPGMFVALLGILFPVFFGWLTGEAFQVANNEAIFFGIIL 120 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 ATSV ++ +L ++ + TK G+TIL A++VDD+L +++L+ ++ + + + Sbjct: 121 AATSVSISVEVLKELNVVNTKEGSTILGASVVDDILVVLVLSFSLSFLTGKSTSNLPLPL 180 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 +LLE +F+ L+ + +++L+E+I + ++VI L +YLA+ L+ + Sbjct: 181 LLLEQLFYFLFIFLLVKWIAPFLMSLAEKIYANSAIIIMSLVICLGMSYLADLIGLSSVI 240 Query: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 GA+ AG+ VS T+ ++ + + +GY++FIP+F VS+G+E D + +F L+ +L+ Sbjct: 241 GAFFAGIAVSQTKVKHEVYNNVEALGYAVFIPVFFVSVGLEVDFSKFSEQILFILILTLV 300 Query: 301 AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT 360 A++ K+IG GA + F A+ VG GMI R E+ALII +G + ++ + V Sbjct: 301 AILTKLIGGYIGAKFSSFSSNSALMVGAGMISRGEMALIILQIGQQSNLIENHYYSPLVI 360 Query: 361 MVVITTLITPFLLKWAFSK 379 +V+++TLI+P +LK+ K Sbjct: 361 VVLLSTLISPLILKYFTKK 379 >emb|CAA51756.1| (X73329) Na/H antiporter homolog [Lactococcus lactis] Length = 379 Score = 234 bits (591), Expect = 1e-60 Identities = 129/379 (34%), Positives = 215/379 (56%), Gaps = 3/379 (0%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 M L+L I+L+ + I S RL PA +GQ+L G++I PS+L +V G + ++SE+G Sbjct: 1 MNDILQLTIVLIASLIATLASRRLKIPAVIGQMLVGILIAPSVLGLVHSGHVLEVMSEIG 60 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 V++L+FLAGLE+D+ K ++ +VA+ GV VP ++ LV+ GYG + F+G V Sbjct: 61 VILLMFLAGLESDLTVLKKNFKASMLVAIGGVIVPLIVFGLVAFSFGYGMSTSFFYGIVF 120 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 ATSV +T +L + KL T+ G+ IL AA+VDD+L ++IL++ + + G + Sbjct: 121 AATSVSITVEVLQEYGKLSTRAGSIILGAAVVDDILAVLILSIFTSFKNGGSGTHLFFQF 180 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 +L + F + + H L+ +++ + T A++I L + LA+ ++ + Sbjct: 181 LL---ELLFFAFLFVVHKLIPRFWKFVQKLPIANKNTIVALIICLGLSLLADSVGMSAVI 237 Query: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 G++ AGL +S TE S KI + IGY +FIP+F V I I L H L+++L+ Sbjct: 238 GSFFAGLAISQTEVSHKIEEYTSAIGYVIFIPVFFVLIAISVQFDSLIHHPWIILLFTLL 297 Query: 301 AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT 360 A++ K I F + E++ +G GMI R E+ALI+A +GL I+T + V Sbjct: 298 AILTKFIPAYFVGKSNKLSTGESMLIGTGMISRGEMALIVAQIGLTSAIITDEVYSELVI 357 Query: 361 MVVITTLITPFLLKWAFSK 379 ++++ T++ PFL+K K Sbjct: 358 VIILATVLAPFLIKLVLKK 376 >pir||B71038 probable Na+/H+-exchanging protein - Pyrococcus horikoshii >gi|3258023|dbj|BAA30706.1| (AP000006) 425aa long hypothetical Na(+)/H(+) antiporter [Pyrococcus horikoshii] Length = 425 Score = 234 bits (590), Expect = 2e-60 Identities = 143/404 (35%), Positives = 228/404 (56%), Gaps = 35/404 (8%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIG---------PSLLDVVEYGSEV 53 + + ++IAKI + R P LG+LL G+ +G L + SEV Sbjct: 6 ILFTIGTAIIIAKIGDSIVERFELPGVLGELLMGMALGNLVYFGLIKSEYLPITMGSSEV 65 Query: 54 -RLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLK 112 L++LG+++LLFL L+TD+E+ K G++A + +MGVFVP LGY + GYG + Sbjct: 66 IDFLAKLGIILLLFLGALDTDIEKLKRTGVTAVVSTIMGVFVPLALGYYALRVMGYGYRE 125 Query: 113 ALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGK 172 A G +LTATS+GLT I+MD+ LR++VG L+A+++DD LGI + ++ A+ S Sbjct: 126 AFAGGVLLTATSIGLTVRIMMDLGALRSEVGAASLSASVIDDFLGIAL--IIFAVGSGSL 183 Query: 173 VEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAE 232 +E+ ++ +FFI+ ++G LV + +E++ + + V I +M IFA LAE Sbjct: 184 LELS------AKIIVFFIITGVLGWYLVDHYIKFAEKLHVEKGVLGLVIGLMFIFAALAE 237 Query: 233 KFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGV 292 + A I G+++AGL++S ++I +++ +IGY IP+F V G ++ V + Sbjct: 238 DWFAAAIEGSFMAGLILSKLPEGKRIMEEVRSIGYGFLIPLFFVHTGAMLNLTVFKNIEA 297 Query: 293 FALVYSL--IAVVGKIIGCGFGA-----------LVARFKPIEAIQVGIGMIPRMEVALI 339 F L + L IAVVGK+IG GFGA L + ++Q+GIG IPR EVAL+ Sbjct: 298 FKLAFVLTTIAVVGKVIGRGFGAWLTAWGRGRGFLFTKQNFRMSLQMGIGSIPRTEVALV 357 Query: 340 IANVGLKEGILTRGD----LAVPVTMVVITTLITPFLLKWAFSK 379 V + G ++ G+ +A + + ++ LITP LLKWAF + Sbjct: 358 DLMVAIHGGAISSGNVPKFIAATLIFITVSVLITPPLLKWAFKE 401 >pir||C75176 na+/h+ antiporter (napa-2) PAB0390 - Pyrococcus abyssi (strain Orsay) >gi|5458000|emb|CAB49490.1| (AJ248284) Na+/H+ antiporter (napA-2) [Pyrococcus abyssi] Length = 426 Score = 230 bits (580), Expect = 2e-59 Identities = 140/402 (34%), Positives = 224/402 (54%), Gaps = 35/402 (8%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIG---------PSLLDVVEYGSEV 53 + + + L++AKI + R P LG+L+ G+++G L + SEV Sbjct: 7 ILFTIGVALILAKIGDAIIERFELPGVLGELIMGMLLGNLVYFGIVSKDYLPITMGSSEV 66 Query: 54 -RLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLK 112 L++LG++ LLFL L+TDVE+ K GL+A I +MGVFVP +LGY GY + Sbjct: 67 IDFLAKLGIIFLLFLGALDTDVEQLKKTGLTATISTLMGVFVPLILGYFALRYMGYSHRE 126 Query: 113 ALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGK 172 A G +LTATS+GLT ++MD+ LR++VG L+A+++DD LGI ++ V S Sbjct: 127 AFAGGVLLTATSIGLTVRVMMDLGVLRSEVGAASLSASVMDDFLGIALIIFAVGSGS--- 183 Query: 173 VEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAE 232 + + +++ FFI+ ++G + + + +ER+ + + + A+ +M +FA LAE Sbjct: 184 -----LLGLSMKIIAFFIITGILGWYSIDKYIRFAERLHVEKGILGMAVGMMFLFAALAE 238 Query: 233 KFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGV 292 + A I G+++ GL++S ++I +++ +IGY L IPIF + G ++ V +A Sbjct: 239 GWFAAAIEGSFMMGLILSKLPEGKRIMEEVRSIGYGLLIPIFFIHTGAMLNLTVFRNADA 298 Query: 293 --FALVYSLIAVVGKIIGCGFGA-----------LVARFKPIEAIQVGIGMIPRMEVALI 339 ALV S IAV+GK+ G GFGA L R ++Q+GIG IPR EVAL+ Sbjct: 299 IKLALVLSTIAVIGKVAGRGFGAWITAWGRGRDFLFTRENFKMSLQMGIGSIPRTEVALV 358 Query: 340 IANVGLKEGILTRGD----LAVPVTMVVITTLITPFLLKWAF 377 V + G ++ D +A + + ++ LITP LLKWAF Sbjct: 359 DLMVAIHGGAISPDDVPKFIAATLIFITVSVLITPPLLKWAF 400 >pir||S74414 Na+/H+-exchanging protein sll0689 - Synechocystis sp. (strain PCC 6803) >gi|1001188|dbj|BAA10332.1| (D64001) NaH-antiporter protein [Synechocystis sp.] Length = 461 Score = 218 bits (550), Expect = 8e-56 Identities = 129/417 (30%), Positives = 223/417 (52%), Gaps = 46/417 (11%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEY------------- 49 V L L +I +K+ G + +RL P LG+L+GGV++G S L ++ + Sbjct: 32 VLLSLVVIYFASKLGGEVCLRLNLPPVLGELVGGVLVGVSALKLLLFPEGGLAPEDSLVI 91 Query: 50 ---------------------GSEVRLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVA 88 + ++SELGV++LLF GLE++++E VG A IVA Sbjct: 92 QLLMGSADLSPEAAQSVFSAQSEVISVISELGVIILLFEIGLESNLKELIRVGPQAAIVA 151 Query: 89 VMGVFVPFLLGYL-VSVLHGYGSLKALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTIL 147 V+GV PF LG + + + G ++ A+F G LTATS+G+T +L ++ +L + G I+ Sbjct: 152 VVGVVTPFSLGTIGLMTIFGVAAIPAIFAGAALTATSIGITAKVLAEINRLSSNEGQIII 211 Query: 148 AAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLS 207 AA++DD+LGI++L ++ ++ G++++ +I ++L F + ILIG L ++L Sbjct: 212 GAAVLDDILGIIVLAVVGSLVKTGEIQISNIIYLILSATGFVVGSILIGRLLSPFYVSLV 271 Query: 208 ERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGY 267 R+ + +I + + +Y+A+ QL I G++ AGL+++ TE + ++I+ + Sbjct: 272 NRMKTRGQLLLVSICVAFVLSYIAQIVQLEAILGSFAAGLILAETEKREDLEEQILPLA- 330 Query: 268 SLFIPIFLVSIGIETDIRVLTHAG-------VFALVYSLIAVVGKIIGCGFGALVARFKP 320 F+P+F V +G +TD+ VL A + A L+A+VGK++ G + Sbjct: 331 DFFVPVFFVCVGAKTDVSVLNPAVPANREGLIIAAFLILVAIVGKVV---TGFTLFGKSE 387 Query: 321 IEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVVITTLITPFLLKWAF 377 + + +G+GMIPR EV L+ A VG G L A + MV++TT + P L+ F Sbjct: 388 LNKLAIGVGMIPRGEVGLVFAGVGAASGALDPATDAAIIVMVIVTTFVAPPWLRAVF 444 >pir||E70380 Na+/H+-exchanging protein - Aquifex aeolicus >gi|2983453|gb|AAC07034.1| (AE000714) Na(+)/H(+) antiporter [Aquifex aeolicus] Length = 408 Score = 213 bits (537), Expect = 3e-54 Identities = 125/385 (32%), Positives = 207/385 (53%), Gaps = 13/385 (3%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVV 62 +FL LAI+L AK+FG + +LG P LG++ GVI+G S+L ++ +++L+ELGV+ Sbjct: 18 LFLHLAILLFSAKLFGSIFRKLGIPPVLGEVTAGVILGQSVLGLIPLSEAIKVLAELGVI 77 Query: 63 MLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVS-VLHGYGSLKALFFGGVLT 121 +LLF GLE D+ VGL + +VA++G +PF G++VS G + +LF GG LT Sbjct: 78 LLLFEVGLEADINMLMRVGLWSTLVAIVGAALPFAGGFIVSYYFFGLDLVASLFMGGALT 137 Query: 122 ATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEII 181 ATS+G+T +L D+ K + + +L AA++DD++G++IL L S V + + Sbjct: 138 ATSIGITVRVLTDLNKHKERFAQIVLGAAVLDDIMGVIILAALYEFSKTKAVHFDTTVNL 197 Query: 182 LLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITG 241 ++ + +FF++ + + L K + + + + + + ++L+ AY A KF I G Sbjct: 198 IIHILMFFLIAPFVANVLAKLLSIAARKTQDMDLIPASIMALILLAAYSAHKFGSPSILG 257 Query: 242 AYLAGLLVS---------MTEGSRKITDKI---MTIGYSLFIPIFLVSIGIETDIRVLTH 289 ++ AGL +S M K+ K+ +T + PIF VS+G+ +++ + Sbjct: 258 SFTAGLALSRRFVIPFAAMLRLDEKLLHKVEESITPLVWVMAPIFFVSVGLALNLKAIDF 317 Query: 290 AGVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGI 349 + +S +V IIG VA E +G M+PR EV LI A G Sbjct: 318 SSPEFWTFSSALIVVAIIGKVLAGFVAPGSLKEKASIGFSMLPRGEVGLIFAEFGRSFKA 377 Query: 350 LTRGDLAVPVTMVVITTLITPFLLK 374 + + AV V +V +TTLI P +LK Sbjct: 378 INEVEYAVIVFVVAVTTLIAPIVLK 402 >pir||C75103 na+/h+ antiporter (napa-4) PAB0809 - Pyrococcus abyssi (strain Orsay) >gi|5458640|emb|CAB50128.1| (AJ248286) Na+/H+ antiporter (napA-4) [Pyrococcus abyssi] Length = 390 Score = 172 bits (432), Expect = 5e-42 Identities = 106/392 (27%), Positives = 205/392 (52%), Gaps = 17/392 (4%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 M +L+I+LV+AK +L + G + +L G+I+GP L +V+ E+++L E G Sbjct: 1 MNYIFDLSILLVVAKSLEWLLKKRGVHPIIAHILTGIILGPFGLAIVKPSEELKVLGEFG 60 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 ++M++ GL ++ + A IVA +GV F+LG+ + ALF G L Sbjct: 61 LIMMMLYMGLTSNFSAISRNKVKATIVATLGVAFSFILGFSTVYFIERNMIAALFVGITL 120 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 T++ +T+ +L+ ++++ ++ + ++ AA DD++ + ++ LL + ++G + + + Sbjct: 121 GNTAIEVTSGVLV-RERVKKEISSVLMGAAFADDIIAVYLIGLLTGI-TQGSFSLYPMVV 178 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 + +++ +F + +LI + K + TF I++ + A+LAE L I Sbjct: 179 LTIKIVVFIVATLLISEFVFKRSARFYNVVKDLHVFFTFTIILTFMLAFLAEDIGLNQII 238 Query: 241 GAYLAGLLVSMTEGSR-----------KITDKIMTIGYSLFIPIFLVSIGI--ETDIRVL 287 GAYLAGL +S + ++ ++ + FIP+F + +G+ + ++R + Sbjct: 239 GAYLAGLTISRLRERKDPMVITRIKLNELISELEVVLLEFFIPLFFIYVGLMFQPNVREI 298 Query: 288 THAGVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKE 347 + + AL+Y L A++GK+IGCG G L+ +AI VG+GM R + L I +GL++ Sbjct: 299 S-VLMIALLY-LAAILGKLIGCGLGMLLFGSSLRDAIIVGVGMGGRGSLELAILKLGLEK 356 Query: 348 GILTRGDLAVPVTMVVITTLITPFLLKWAFSK 379 G++ A V + ++T L TP + K Sbjct: 357 GLINESLFATIVIVSMLTALSTPIFFRGVIRK 388 >pir||H71083 probable Na+/H+-exchanging protein - Pyrococcus horikoshii >gi|3257347|dbj|BAA30030.1| (AP000004) 390aa long hypothetical Na(+)/H(+) antiporter [Pyrococcus horikoshii] Length = 390 Score = 172 bits (431), Expect = 7e-42 Identities = 112/392 (28%), Positives = 201/392 (50%), Gaps = 17/392 (4%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 M +L+I+LV+AK +L + G + +L G+I+GP L +V SE+++L E G Sbjct: 1 MSYIFDLSILLVVAKSLEWLLKKKGIHPIIAHILTGIILGPFGLSIVLPTSELKVLGEFG 60 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 ++M++ GL ++ + A +VA+ GV F+LG+L + ALF G L Sbjct: 61 LIMMMLYMGLTSNFSAISRNKVKASVVAMFGVAFSFILGFLTVYFLEKSLIAALFVGITL 120 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 T++ +T+ +L+ ++++ + + ++ AA DD++ + ++ +L ++ G + + + Sbjct: 121 GNTAIEVTSGVLV-RERVKKDISSVLMGAAFADDIIAVYLIGILTGITQGG---ISGLSL 176 Query: 181 ILLEVAI-FFILGILIGHPLV-KEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAG 238 + L + I FILG+L+ V K I TF IV+ A++A+ L Sbjct: 177 VFLTIKIVIFILGVLMLSEFVFKRSTRFYNIIRDLHIFFTFTIVLTFTLAFIAQDIGLNQ 236 Query: 239 ITGAYLAGLLVSMTEGSR-----------KITDKIMTIGYSLFIPIFLVSIGIETDIRVL 287 I GAYLAGL +S + ++ +++ + FIP+F V +G+ + V Sbjct: 237 IIGAYLAGLTISRLRERKDPMVITRIKLNELIEELEIVLVEFFIPLFFVYVGLMFNPNVR 296 Query: 288 THAGVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKE 347 + + L+ AV+GK+IGCG G + +AI VGIGM R + L I +GL++ Sbjct: 297 DISILLILLLYASAVLGKLIGCGLGMKIFGSSIRDAIIVGIGMGGRGSLELAILKLGLEK 356 Query: 348 GILTRGDLAVPVTMVVITTLITPFLLKWAFSK 379 G++ G A V + ++T L TP L ++ K Sbjct: 357 GLIDEGIFATVVIVSMLTALSTPVLFRYTVRK 388 >pir||F70155 Na+/H+ antiporter (napA) homolog - Lyme disease spirochete >gi|2688368|gb|AAC66821.1| (AE001150) Na+/H+ antiporter (napA) [Borrelia burgdorferi] Length = 701 Score = 170 bits (427), Expect = 2e-41 Identities = 124/402 (30%), Positives = 208/402 (50%), Gaps = 36/402 (8%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSL-----------LDVVEYGS-- 51 + LAII++ + G L ++G P +GQ+ G+I+ P+ L + + G Sbjct: 36 MSLAIIVISSISIGNLVAKIGIPKVIGQITAGIILSPNAFGKIQIPLLFPLGITQIGENY 95 Query: 52 ----EVRLLSELGVVMLLFLAGLETDVE---EFKHVGLSAFIVAVMGVFVPFLLGYLVSV 104 ++ +S + ++LLF AGLETD++ +F G I V+G F F+L + S+ Sbjct: 96 LINEKIFAISTIASIILLFTAGLETDLKLFIKFLPRGGIIGITEVVGTFTSFVL--MASI 153 Query: 105 LHGYGSLK--ALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILT 162 + + +LF G + T TS G+ SIL KK+ T G TI++ +I+DDVL +++LT Sbjct: 154 IFNVPLISPTSLFIGIIGTPTSAGIAASILSAKKKMSTSEGVTIISTSIIDDVLSMLMLT 213 Query: 163 LLVAMSSRGKVEVEDIEIILLEVAIF--FILGILIGHPLVKEVLTLSERITLPETVTTFA 220 ++ +S + D++I AI ++ + + L+ TLS + +VT Sbjct: 214 SVITISR----SISDLDIASSIKAIVQNIVIWLCLTFSLIYISETLSRLLKKLNSVTLAT 269 Query: 221 IVIMLIFAYLAEKFQLAG---ITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVS 277 ++ + + +A FQ G + GAY+ GL +S T+ I DK+ TI FIPIF S Sbjct: 270 VITLSLALTIASIFQNLGMSFVVGAYVFGLAMSKTDIVYVIQDKL-TIFERFFIPIFFTS 328 Query: 278 IGIETDIRVLTHAGVF--ALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRME 335 IG+ +DI + V L S IA++ K I C AL F + A+++ GM+PR E Sbjct: 329 IGLMSDINEILSKEVLILGLAISAIAIITKSIFCFIPALFLGFNKLGALKIATGMVPRGE 388 Query: 336 VALIIANVGLKEGILTRGDLAVPVTMVVITTLITPFLLKWAF 377 V+LI+ANV L G +++ + + MV + T+I ++ + F Sbjct: 389 VSLIMANVALSSGFISQKIFGIIIIMVFLPTIIATPIINFLF 430 >pir||B64459 Na+/H+-exchanging protein - Methanococcus jannaschii >gi|1591911|gb|AAB99281.1| (U67568) NA(+)/H(+) antiporter (napA) [Methanococcus jannaschii] Length = 388 Score = 169 bits (423), Expect = 6e-41 Identities = 108/375 (28%), Positives = 203/375 (53%), Gaps = 12/375 (3%) Query: 9 IILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLA 68 IIL I I L + PA ++ G+IIGP L++++ +++L++ G +ML+FLA Sbjct: 10 IILSIIFIVPNLLKKFNIPAITSIMIAGIIIGPYGLNILQVDETLKILADFGAIMLMFLA 69 Query: 69 GLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVGLT 128 GLE D E K ++ I+++ + +P + GYL+ G G + +L + + + SV + Sbjct: 70 GLEVDNETLKQEFKNSLILSLFSLLIPGVGGYLIGQYLGLGFIGSLLYAVIFASHSVAIV 129 Query: 129 TSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVAIF 188 +IL ++K ++T++GT IL+A I+ D+ +++L++++ + G E++ LLE ++ Sbjct: 130 YAILEELKMVKTRLGTIILSATIIVDLFTLLLLSVVIKLGIGG----ENVGTFLLETVLY 185 Query: 189 FILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLL 248 + +L L K +L + E++ + + I+ I + E + I GA++ G+ Sbjct: 186 IGVLLLAIPSLSKNILGVFEKLHAQR--IHYVLFIIFIAIIVGEVIGIHPIVGAFICGVA 243 Query: 249 VS----MTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTH-AGVFALVYSLIAVV 303 VS E + + IGY FIPIF + +G+ET+IRV+ + + + L+ +LI+ V Sbjct: 244 VSEALTKEEHDELLNKNLNAIGYGFFIPIFFLVLGMETNIRVIFNLSNLELLLITLISAV 303 Query: 304 GKIIGCGFGAL-VARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMV 362 GF AL + F I+ G+ +P++ +L+ A++G + G++ V + Sbjct: 304 ALKFISGFIALRILGFDRIKNTIGGLLTVPKISASLVAASIGRELGLIGNEIFVTIVALS 363 Query: 363 VITTLITPFLLKWAF 377 VIT ITP ++K F Sbjct: 364 VITATITPIVVKHIF 378 >pir||C82955 probable sodium/proton antiporter PA5529 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9951867|gb|AAG08914.1|AE004965_6 (AE004965) probable sodium/proton antiporter [Pseudomonas aeruginosa] Length = 585 Score = 166 bits (417), Expect = 3e-40 Identities = 102/373 (27%), Positives = 195/373 (51%), Gaps = 3/373 (0%) Query: 6 ELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSL--LDVVEYGSEVRLLSELGVVM 63 +LA+I+++A + L RL P LG ++ G IIGP ++ ++ L+ELGV+ Sbjct: 9 DLAVIMLVAGVVTILFHRLRQPVVLGYIVAGFIIGPHTPPFGLIHDEDTIKTLAELGVIF 68 Query: 64 LLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTAT 123 L+F GLE + + VG +AFI A + + + +G+ + + ++ +LF G +L + Sbjct: 69 LMFCLGLEFSLRKLFQVGATAFIAAFLEIVLMIWIGFEIGRFFEWSTMDSLFLGAILAIS 128 Query: 124 SVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILL 183 S + L D+K + I IV+D+LGI I+ LL ++ G VE ++ + Sbjct: 129 STTIIVKALGDLKMKNERFAQLIFGVLIVEDILGIGIIALLSGIAVSGSVETGEVFSTVG 188 Query: 184 EVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAY 243 ++++F I+ +++G LV +L + E + + + F L K + + + GA+ Sbjct: 189 KLSLFMIVALVVGILLVPRLLAYVAKFESNEMLLVTVLGLCFGFCLLVVKLEYSMVLGAF 248 Query: 244 LAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVV 303 L G +++ + +I ++++ +F IF V+IG+ D ++L + ++ V+ Sbjct: 249 LIGAIMAESRQLVQI-ERLIEPVRDMFSAIFFVAIGLLIDPKILVEYAWPIALITVAVVL 307 Query: 304 GKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVV 363 GK+ CG GA +A +++VG+G+ E + IIA +G+ + + V V + Sbjct: 308 GKMFSCGMGAFIAGNDGRTSLRVGMGLSQIGEFSFIIAALGMTLKVTSDFLYPVAVAVSA 367 Query: 364 ITTLITPFLLKWA 376 ITTL+TP+L++ A Sbjct: 368 ITTLLTPYLIRAA 380 >dbj|BAB11467.1| (AB005233) Na+/H+ antiporter-like protein [Arabidopsis thaliana] Length = 810 Score = 145 bits (363), Expect = 6e-34 Identities = 108/389 (27%), Positives = 198/389 (50%), Gaps = 28/389 (7%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLL-------DVV---EYGSEVR 54 L++ I++V+ ++ YL L P + +++GG+++GPSLL D V + + + Sbjct: 36 LQIVIVIVLTRVLAYLLRPLRQPRVIAEVIGGIMLGPSLLGRSKAFLDAVFPKKSLTVLE 95 Query: 55 LLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLG------YLVSVLHGY 108 L+ LG++ LFLAGLE D + + G A +A+ G+ +PF LG ++ G Sbjct: 96 TLANLGLLFFLFLAGLEIDTKALRRTGKKALGIALAGITLPFALGIGSSFVLKATISKGV 155 Query: 109 GSLKALFFGGV-LTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAM 167 S L F GV L+ T+ + IL ++K L T++G ++AA V+DV ++L L +A+ Sbjct: 156 NSTAFLVFMGVALSITAFPVLARILAELKLLTTEIGRLAMSAAAVNDVAAWILLALAIAL 215 Query: 168 SSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLT--LSERITLPETVTTFAIVIML 225 S + + + L A F++G P + ++ E + ET + ++L Sbjct: 216 SGSNTSPLVSLWVFLSGCA--FVIGASFIIPPIFRWISRRCHEGEPIEETYICATLAVVL 273 Query: 226 IFAYLAEKFQLAGITGAYLAGLLVSMTEG--SRKITDKIMTIGYSLFIPIFLVSIGIETD 283 + ++ + + + GA++ G+L+ EG + + +K+ + LF+P++ V+ G++T+ Sbjct: 274 VCGFITDAIGIHSMFGAFVVGVLIP-KEGPFAGALVEKVEDLVSGLFLPLYFVASGLKTN 332 Query: 284 IRVLTHA---GVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALII 340 + + A G+ LV + A GKI+G +L + EAI +G M + V LI+ Sbjct: 333 VATIQGAQSWGLLVLV-TATACFGKILGTLGVSLAFKIPMREAITLGFLMNTKGLVELIV 391 Query: 341 ANVGLKEGILTRGDLAVPVTMVVITTLIT 369 N+G +L A+ V M + TT IT Sbjct: 392 LNIGKDRKVLNDQTFAIMVLMALFTTFIT 420 >emb|CAB45049.1| (AL078635) putative integral membrane ion antiporter [Amycolatopsis orientalis] Length = 409 Score = 142 bits (355), Expect = 6e-33 Identities = 121/394 (30%), Positives = 199/394 (49%), Gaps = 34/394 (8%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLD----VVEYGSEVR---- 54 + L+LA+I+V+A++ G ++ RL P +G+LL G+++GP+L + ++VR Sbjct: 9 LLLDLAVIVVLARLLGAVARRLDQPPVIGELLAGILLGPTLFGEGFAAALFPTDVRPFLA 68 Query: 55 LLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLG-----YLV---SVLH 106 L+ +GV M +F+ GLE + + G A V+V + +PF LG YL V H Sbjct: 69 ALANVGVAMFMFMVGLELEQTLLRGRGKLALTVSVSSIVLPFTLGVGLAFYLAMNRPVEH 128 Query: 107 GYGSLKALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVA 166 G L LF G ++ T+ + IL D LRT +G L A + DVL +L ++V Sbjct: 129 RLGFL--LFIGAAMSVTAFPVLARILQDRGMLRTMLGGLALTCAAIGDVLAWCLLAVVVI 186 Query: 167 MSSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLI 226 +S G E I+L + + +L ++ PL++++ T LP TV A LI Sbjct: 187 VSG-GASGTEQWLIVLGPIYVALMLWVV--RPLLRKLFTAGVTGALP-TVLAGA----LI 238 Query: 227 FAYLAEKFQLAGITGAYLAGLLVSMTEGS----RKITDKIMTIGYSLFIPIFLVSIGIET 282 + E L I GA+L G++V EG+ +I D++ +L +P+F + G++ Sbjct: 239 SGAVTELIGLHFIFGAFLFGVIVP-REGTDTLRHRIIDRVEEFNSALLLPVFFIVSGLKV 297 Query: 283 DIRVLTHAGV--FALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALII 340 ++ L+ G+ F LV L+A+ GK G GA + ++ + M R LII Sbjct: 298 NLSTLSATGLVEFGLVL-LVAIAGKFGGAFVGARLHGLPARKSAALATLMNTRGLTELII 356 Query: 341 ANVGLKEGILTRGDLAVPVTMVVITTLITPFLLK 374 VGL+ G+L + ++ V M VITT + LL+ Sbjct: 357 LTVGLQLGVLDQSLYSIMVAMAVITTAMAGPLLR 390 >gb|AAK41390.1| Na(+)/H(+) antiporter [Sulfolobus solfataricus] Length = 391 Score = 141 bits (353), Expect = 1e-32 Identities = 103/380 (27%), Positives = 195/380 (51%), Gaps = 18/380 (4%) Query: 6 ELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGP----SLLD------VVEYGSEVRL 55 +++I +++A+I L + G P +G+LL G+IIGP SLL+ ++ S + Sbjct: 10 DVSIFILLAEILSSLVQKYGLPKLIGELLAGMIIGPYALGSLLNQLLGFPLIGINSYIEF 69 Query: 56 LSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALF 115 L+E V++L+F +GLE + K G+ F+ A G +PF Y + +G AL Sbjct: 70 LAEFSVILLIFASGLEHGIAPIKSSGILGFLGATFGALLPFFAAYYF-YISSFGLDSALI 128 Query: 116 FGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEV 175 G + ATS+ SI+ + KL+ K ++++A DDV+ +++L++++A+ V Sbjct: 129 LGTAMGATSLAAVASII-EEGKLKGKGINFMVSSAAADDVVDLLLLSVVIAILQGESTSV 187 Query: 176 EDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQ 235 I + ++ + + +++ +++ L+ ++ ++RI+ + + F + ++ L Sbjct: 188 TSISLKIIALVVIWVVILVVSIILIPKI---TDRIS-DKYIEEFPLAVLFGLTLLMVSLG 243 Query: 236 LAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLT-HAGVFA 294 + I A++AG+ + + + KI + T+ S+F P+F V IG E + L + + + Sbjct: 244 YSPIISAFVAGVAFANSVKNSKIKEISSTL-LSVFGPLFFVYIGAEVNFLTLNLNTVILS 302 Query: 295 LVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGD 354 L + IA + K +G AL A V +GM+PR E L+IA++GL L + + Sbjct: 303 LELTAIATIFKWLGIFPFALAYLRNAKAANTVALGMVPRGETGLVIASLGLSYNALNQEE 362 Query: 355 LAVPVTMVVITTLITPFLLK 374 V M + TTLI L K Sbjct: 363 FEGIVFMSIFTTLIGSALFK 382 >pir||T05602 hypothetical protein F9D16.170 - Arabidopsis thaliana >gi|4454039|emb|CAA23036.1| (AL035394) putative Na+/H+-exchanging protein [Arabidopsis thaliana] >gi|7269218|emb|CAB79325.1| (AL161559) putative Na+/H+-exchanging protein [Arabidopsis thaliana] Length = 820 Score = 141 bits (353), Expect = 1e-32 Identities = 105/400 (26%), Positives = 199/400 (49%), Gaps = 24/400 (6%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVV----------EYGSE 52 + L++ I+L++ ++ +L L P + +++GG+++GPS L + + Sbjct: 33 LILQICIVLLLTRLLAFLLRPLRQPRVIAEIVGGILLGPSALGKSTKFINTVFPPKSLTV 92 Query: 53 VRLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLG----YLVSVLHGY 108 + L+ LG++ LFL GLE D + K G A +A+ G+ +PF+LG + + Sbjct: 93 LDTLANLGLIFFLFLVGLELDPKSLKRTGKRALSIALAGITLPFVLGIGTSFALRSSIAD 152 Query: 109 GSLKA---LFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLV 165 G+ KA +F G L+ T+ + IL ++K L T +G L+AA V+DV ++L L V Sbjct: 153 GASKAPFLVFMGVALSITAFPVLARILAEIKLLTTDIGKIALSAAAVNDVAAWILLALAV 212 Query: 166 AMSSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVL-TLSERITLPETVTTFAIVIM 224 A+S G + + + L F + I + P +K + E + E + I+ Sbjct: 213 ALSGEGSSPLTSLWVFLSGCG-FVLFCIFVVQPGIKLIAKRCPEGEPVNELYVCCTLGIV 271 Query: 225 LIFAYLAEKFQLAGITGAYLAGLLVSMTEG--SRKITDKIMTIGYSLFIPIFLVSIGIET 282 L +++ + + + GA++ G++ EG + + +K+ + LF+P++ VS G++T Sbjct: 272 LAASFVTDFIGIHALFGAFVIGVIFP-KEGNFANALVEKVEDLVSGLFLPLYFVSSGLKT 330 Query: 283 DIRVLTHAGVFALVYSLI--AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALII 340 ++ + A + L+ +I A GKIIG +L + +++ +G M + V LI+ Sbjct: 331 NVATIQGAQSWGLLVLVIFNACFGKIIGTVLVSLYCKVPLDQSLALGFLMNTKGLVELIV 390 Query: 341 ANVGLKEGILTRGDLAVPVTMVVITTLITPFLLKWAFSKG 380 N+G G+L A+ V M + TT +T L+ + G Sbjct: 391 LNIGKDRGVLNDQIFAIMVLMAIFTTFMTTPLVLAVYKPG 430 >dbj|BAB02053.1| (AB022219) Na+/H+ exchangeing protein-like [Arabidopsis thaliana] Length = 800 Score = 140 bits (350), Expect = 2e-32 Identities = 98/388 (25%), Positives = 187/388 (47%), Gaps = 22/388 (5%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLL-------DVVEYGSEVRL 55 + L++ +++V ++ Y L P + +++GG+++GPS L D + + + Sbjct: 35 IILQIVLVVVFTRLLAYFLKPLKQPRVIAEIIGGILLGPSALGRSKAYLDTIFPKKSLTV 94 Query: 56 LSEL---GVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVS------VLH 106 L L G++ LFL GLE D K G + ++A+ G+ +PF++G S + Sbjct: 95 LDTLANIGLLFFLFLVGLELDFAAIKKTGKKSLLIAIAGISLPFIVGVGTSFVLSATISK 154 Query: 107 GYGSLKALFFGGV-LTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLV 165 G L + F GV L+ T+ + IL ++K L T +G ++AA V+DV ++L L + Sbjct: 155 GVDQLPFIVFMGVALSITAFPVLARILAELKLLTTDIGRMAMSAAGVNDVAAWILLALAI 214 Query: 166 AMSSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIML 225 A+S G + + ++L + I L E + E + ++L Sbjct: 215 ALSGDGTSPLVSVWVLLCGTGFVIFAVVAIKPLLAYMARRCPEGEPVKELYVCVTLTVVL 274 Query: 226 IFAYLAEKFQLAGITGAYLAGLLVSMTEG--SRKITDKIMTIGYSLFIPIFLVSIGIETD 283 +++ + + + GA++ G +V+ EG R +T+KI + L +P++ + G++TD Sbjct: 275 AASFVTDTIGIHALFGAFVVG-IVAPKEGPFCRILTEKIEDLVSGLLLPLYFAASGLKTD 333 Query: 284 IRVLTHAGVFALVYSLIAVV--GKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIA 341 + + A + L+ +I GKI+G +++ + EA+ +G M + V LI+ Sbjct: 334 VTTIRGAQSWGLLVLVILTTCFGKIVGTVGSSMLCKVPFREAVTLGFLMNTKGLVELIVL 393 Query: 342 NVGLKEGILTRGDLAVPVTMVVITTLIT 369 N+G +L A+ V M + TT IT Sbjct: 394 NIGKDRKVLNDQAFAILVLMALFTTFIT 421 >gb|AAF26906.1|AF210843_3 (AF210843) unknown [Sorangium cellulosum] Length = 713 Score = 134 bits (334), Expect = 2e-30 Identities = 102/386 (26%), Positives = 180/386 (46%), Gaps = 19/386 (4%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSE-------- 58 LA+ILV A+ G L+ RL P LG+L GGV++GPS++ + G L E Sbjct: 16 LALILVTARASGELARRLRQPEVLGELFGGVVLGPSVVGALAPGFHRALFQEPAVGVVLS 75 Query: 59 ----LGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSL-KA 113 +G ++LL +AG+E DV + + A+ + P G S L L Sbjct: 76 GISWIGALLLLLMAGIEVDVGILRKEARPGALSALGAIAPPLAAGAAFSALVLDRPLPSG 135 Query: 114 LFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKV 173 LF G VL+ T+V + +L++ + +R LAA +V +V V++ + SS G Sbjct: 136 LFLGIVLSVTAVSVIAKVLIERESMRRSYAQVTLAAGVVSEVAAWVLVAM--TSSSYGAS 193 Query: 174 EVEDIEIILLEVAIFFILGILIGHPLVKEVLT-LSERITLPETVTTFAIVIMLIFAYLAE 232 + L + F + +L+G L + +++ + + + +V+ + A L + Sbjct: 194 PALAVARSALLASGFLLFMVLVGRRLTHLAMRWVADATRVSKGQVSLVLVLTFLAAALTQ 253 Query: 233 KFQLAGITGAYLAGLLV-SMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAG 291 + L + GA+ G+L+ S +R + D + T+ LF P+F V G+ D+ L Sbjct: 254 RLGLHPLLGAFALGVLLNSAPRTNRPLLDGVQTLVAGLFAPVFFVLAGMRVDVSQLRTPA 313 Query: 292 VFALVYSLI--AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGI 349 + V L+ A K++ GA + + EA V +G+ + LI+A VG++ G+ Sbjct: 314 AWGTVALLLATATAAKVVPAALGARLGGLRGSEAALVAVGLNMKGGTDLIVAIVGVELGL 373 Query: 350 LTRGDLAVPVTMVVITTLITPFLLKW 375 L+ + + ++T +P LL W Sbjct: 374 LSNEAYTMYAVVALVTVTASPALLIW 399 >pir||S74951 Na+/H+-exchanging protein slr1595 - Synechocystis sp. (strain PCC 6803) >gi|1652066|dbj|BAA16991.1| (D90902) Na/H antiporter [Synechocystis sp.] Length = 410 Score = 134 bits (333), Expect = 2e-30 Identities = 103/397 (25%), Positives = 191/397 (47%), Gaps = 27/397 (6%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSE---------- 52 + + +I+ +A++ G L R P +G+++ G+++GPSLL ++ E Sbjct: 9 ILANIIVIIGLARLIGLLFARFQQPPVIGEIIAGIMLGPSLLGLLSPALEKSFFPATTQP 68 Query: 53 -VRLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSL 111 + LLSE+G++ +FL GLE + + + A + + + +F PF+LG ++S Y Sbjct: 69 FLYLLSEIGLIFYMFLVGLELNPQYLRQKLKVAILTSNVSIFFPFVLGIVLSFFVLYSLN 128 Query: 112 K---------ALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILT 162 + ALF G ++ T+ + IL D +T +GT L A VDD+ +L Sbjct: 129 QPNKTSFIPFALFIGAAMSITAFPVLARILKDTGLDKTPLGTLGLTCASVDDISAWCLLA 188 Query: 163 LLVAMSSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVL-TLSERITLPETVTTFAI 221 + +A++ + LL + ++ + + +G K +L ++ L + + TF Sbjct: 189 IAIAVTRTD--NIFGAFPTLLGIIVYTVFMVTLGRKFFKYILRNYGQKNYLSQGLLTFIY 246 Query: 222 VIMLIFAYLAEKFQLAGITGAYLAG-LLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGI 280 +++++ A L E + I G ++ G +L T S ++ K + +PIF G+ Sbjct: 247 IMVILSAMLTEWIGIDVIFGGFILGAILPKNTNLSTELATKTEDFVSTFLLPIFFAYSGL 306 Query: 281 ETDIRVLTHAGVFALVYSLI--AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVAL 338 TD+ +L ++A+ ++ A+ GK G + EA +G M R L Sbjct: 307 STDLGLLNKPYLWAVCALVVAAAIAGKYCGVYVTTRALGVEKQEAKALGWLMNTRGLTEL 366 Query: 339 IIANVGLKEGILTRGDLAVPVTMVVITTLIT-PFLLK 374 II NVGLK G+++ + V M +ITT+IT P ++K Sbjct: 367 IILNVGLKLGVISPVIFTMFVIMAIITTIITSPLVVK 403 >pir||T45912 hypothetical protein F5K20.20 - Arabidopsis thaliana >gi|7629992|emb|CAB88334.1| (AL132960) putative protein [Arabidopsis thaliana] Length = 842 Score = 132 bits (330), Expect = 5e-30 Identities = 102/400 (25%), Positives = 192/400 (47%), Gaps = 35/400 (8%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDV-VEYGSEV-------- 53 + ++ A+I+ +++ L L P + +++GG+++GPS L + Y + Sbjct: 29 LIVQTALIIAVSRFLAVLFKPLRQPKVIAEIVGGILLGPSALGRNMAYMDRIFPKWSMPI 88 Query: 54 -RLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLG-----------YL 101 ++ +G++ LFL GLE D+ + G AF +AV G+ +PF+ G Y Sbjct: 89 LESVASIGLLFFLFLVGLELDLSSIRRSGKRAFGIAVAGITLPFIAGVGVAFVIRNTLYT 148 Query: 102 VSVLHGYGSLKALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVIL 161 + GY +F G L+ T+ + IL ++K L T++G T +AAA +DV ++L Sbjct: 149 AADKPGYAEF-LVFMGVALSITAFPVLARILAELKLLTTQIGETAMAAAAFNDVAAWILL 207 Query: 162 TLLVAMSSRG------KVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLS--ERITLP 213 L VA++ G K +LL A F + +++ P +K V E + Sbjct: 208 ALAVALAGNGGEGGGEKKSPLVSLWVLLSGAGFVVFMLVVIRPGMKWVAKRGSPENDVVR 267 Query: 214 ETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLLVSMT-EGSRKITDKIMTIGYSLFIP 272 E+ + +++ + + + I GA++ GL + E +++ ++I L +P Sbjct: 268 ESYVCLTLAGVMVSGFATDLIGIHSIFGAFVFGLTIPKDGEFGQRLIERIEDFVSGLLLP 327 Query: 273 IFLVSIGIETDIRVLTHA---GVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIG 329 ++ + G++TD+ + A G+ LV + A GKI+G A++ + EA+ +G Sbjct: 328 LYFATSGLKTDVAKIRGAESWGMLGLVV-VTACAGKIVGTFVVAVMVKVPAREALTLGFL 386 Query: 330 MIPRMEVALIIANVGLKEGILTRGDLAVPVTMVVITTLIT 369 M + V LI+ N+G ++ +L A+ V M + TT IT Sbjct: 387 MNTKGLVELIVLNIGKEKKVLNDETFAILVLMALFTTFIT 426 >gi|6322367 Yjl094cp [Saccharomyces cerevisiae] >gi|731972|sp|P40309|YJJ4_YEAST HYPOTHETICAL 97.1 KD PROTEIN IN BCK1-TOK1 INTERGENIC REGION >gi|630170|pir||S46584 probable membrane protein YJL094c - yeast (Saccharomyces cerevisiae) >gi|521094|emb|CAA54359.1| (X77087) 12 transmembrane domains; J0909 ORF [Saccharomyces cerevisiae] >gi|1008268|emb|CAA89387.1| (Z49369) ORF YJL094c [Saccharomyces cerevisiae] Length = 873 Score = 131 bits (326), Expect = 1e-29 Identities = 100/396 (25%), Positives = 197/396 (49%), Gaps = 36/396 (9%) Query: 6 ELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLL-DVVEYGSEV---------RL 55 + +IL++ + + P + +++ GVI+GP++ + Y + + L Sbjct: 29 QACLILLVCNLIHIPFSMMRQPKVISEVISGVILGPTIFGQIPNYTNTIFPTSSIPGLNL 88 Query: 56 LSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSV--LHGYG---- 109 ++ LG+++ +F GLE D+ K A ++ ++ + VPF G L+++ H Y Sbjct: 89 VANLGIILFMFFLGLEVDIAFIKKHLKKALVIGIVTLAVPFGFGCLLAIPLFHTYANKTE 148 Query: 110 -------SLKALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILT 162 S+ +F ++ T+ + IL +++ ++ + G +LAA I++D++G ++L Sbjct: 149 GERHIKFSVFMVFIAVSISVTAFPVLCRILNELRLIKDRAGIVVLAAGIINDIMGWILLA 208 Query: 163 LLVAMSSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERI--TLPETVTTFA 220 L + +SS V + I+L+ A F I + + L++ VL + + + P + T Sbjct: 209 LSIILSSAEGSPVNTVYILLITFAWFLIYFFPLKY-LLRWVLIRTHELDRSKPSPLATMC 267 Query: 221 IV-IMLIFAYLAEKFQLAGITGAYLAGLLVSMTEG-SRKITDKIMTIGYSLFIPIFLVSI 278 I+ IM I AY + + I GA++AGL+V + K+T+++ I +FIPI+ Sbjct: 268 ILFIMFISAYFTDIIGVHPIFGAFIAGLVVPRDDHYVVKLTERMEDIPNIVFIPIYFAVA 327 Query: 279 GIETDIRVLTHAGVFALVYSL--IAVVGKIIGCGFGALVARFKPI---EAIQVGIGMIPR 333 G+ D+ +L + V++ IA+ KII G L A+ + EA G+ M + Sbjct: 328 GLNVDLTLLNEGRDWGYVFATIGIAIFTKIIS---GTLTAKLTGLFWREATAAGVLMSCK 384 Query: 334 MEVALIIANVGLKEGILTRGDLAVPVTMVVITTLIT 369 V +++ VGL GI++R + V M +++T +T Sbjct: 385 GIVEIVVLTVGLNAGIISRKIFGMFVLMALVSTFVT 420 >gb|AAF24561.1|AC007764_3 (AC007764) F22C12.7 [Arabidopsis thaliana] Length = 868 Score = 131 bits (325), Expect = 2e-29 Identities = 97/359 (27%), Positives = 173/359 (48%), Gaps = 27/359 (7%) Query: 35 GGVIIGPSLLD-VVEYGSEV---------RLLSELGVVMLLFLAGLETDVEEFKHVGLSA 84 GG+++GPS L + Y + + L+ LG+++ LFL GLE D+ + G A Sbjct: 131 GGILLGPSALGRITSYKNSIFPARSLTVLDTLANLGLLLFLFLVGLEIDLTSLRRTGKKA 190 Query: 85 FIVAVMGVFVPFLLGYLVSVLHGYGSLKA---------LFFGGVLTATSVGLTTSILMDM 135 +A G+ +PF +G + S S +F G L+ T+ G+ IL ++ Sbjct: 191 ISIAAAGMLLPFGMGIVTSFAFPEASSSGDNSKVLPFIIFMGVALSITAFGVLARILAEL 250 Query: 136 KKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVAIFFILGILI 195 K L T +G + AA ++DV V+L L V++S + + ++L +A F++ + Sbjct: 251 KLLTTDLGRISMNAAAINDVAAWVLLALAVSLSGDRNSPLVPLWVLLSGIA--FVIACFL 308 Query: 196 GHPLVKEVLT--LSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLLVSMTE 253 P + + ++ E + E A+ +L+ + + + I GA++ G+L Sbjct: 309 IVPRIFKFISRRCPEGEPIGEMYVCVALCAVLLAGFATDAIGIHAIFGAFVMGVLFPKGH 368 Query: 254 GSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHA---GVFALVYSLIAVVGKIIGCG 310 S I +KI + L +P++ V G++TDI + G ALV + A GKI+G Sbjct: 369 FSDAIVEKIEDLVMGLLLPLYFVMSGLKTDITTIQGVKSWGRLALVI-VTACFGKIVGTV 427 Query: 311 FGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVVITTLIT 369 AL+ + + E++ +G+ M + V LI+ N+G +L+ A+ V M + TT IT Sbjct: 428 SVALLCKVRLRESVVLGVLMNTKGLVELIVLNIGKDRKVLSDQTFAIMVLMAIFTTFIT 486 >pir||S76532 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1001647|dbj|BAA10378.1| (D64002) Na(+)/H(+) antiporter [Synechocystis sp.] Length = 698 Score = 127 bits (315), Expect = 3e-28 Identities = 102/384 (26%), Positives = 191/384 (49%), Gaps = 25/384 (6%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSE-VRLLSELGVVM 63 ++ I+L++ I + RL P +G L G+++G S L V+ SE ++L +++G + Sbjct: 14 IDFTILLLVTLILPPIFERLKLPGLVGLLFAGIVLGKSGLGVLNEDSESIKLFTDIGKIY 73 Query: 64 LLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTAT 123 L+F+AGLE D+ +F+ + + + VP L G V + GY S A G L A+ Sbjct: 74 LMFVAGLEIDMVDFRRTRNRSLLYGSLTFAVPLLTGLAVGLTFGY-SFNASVLLGSLFAS 132 Query: 124 SVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILL 183 L I+ + +R + + A I D+ +++L + +++ S G + + L+ Sbjct: 133 HTLLGYPIVQRLGIVRNQAVMVTIGATIFTDIAALLVLAICISIHS-GSFSPAGLVVQLV 191 Query: 184 EVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIF--AYLAEKFQLAGITG 241 +A++ L +LIG R T E F V++ +F + +E + I G Sbjct: 192 AIAVYSAL-VLIGFDWAGREYF---RRTGDEQSNQFLFVLLAVFLASVGSELINVDKIVG 247 Query: 242 AYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIR--VLTHAGVFALVYSL 299 A+LAGL V+ G+ + +K+ +G +LFIP F + IG+ D+ ++T +F LV ++ Sbjct: 248 AFLAGLAVNDVLGNSPVKEKVEFLGTTLFIPFFFIGIGLLLDLPAFLVTLTTLFPLVVAI 307 Query: 300 IAVVGKIIGCGFGALVARFKP----IEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDL 355 VVG I+ G A++A++K +E + + IP++ L A G + + GD Sbjct: 308 --VVGLILSKGVAAILAQWKLGYTWVEGLTMWSLSIPQVAATLAAAVAGY-QAVNAAGDR 364 Query: 356 AVP-------VTMVVITTLITPFL 372 V + +++IT+++ P + Sbjct: 365 LVSETVLNTIIVLMLITSIVGPLM 388 >gb|AAD22684.1|AC007063_10 (AC007063) putative Na+/H+ antiporter [Arabidopsis thaliana] Length = 821 Score = 125 bits (312), Expect = 6e-28 Identities = 93/392 (23%), Positives = 193/392 (48%), Gaps = 29/392 (7%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLD--------VVEYGSEVRL- 55 L+L +++V+ + F ++ P + ++LGG+++GPS+L + S + L Sbjct: 42 LQLTLVVVVTRFFVFILKPFRQPRVISEILGGIVLGPSVLGRSTKFAHTIFPQRSVMVLE 101 Query: 56 -LSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSV-LH------G 107 ++ +G++ LFL G+E D+ + G A +A+ G+ +PFL+G S +H G Sbjct: 102 TMANVGLLYFLFLVGVEMDIMVVRKTGKRALTIAIGGMVLPFLIGAAFSFSMHRSEDHLG 161 Query: 108 YGSLKALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAM 167 G+ LF G L+ T+ + IL ++K + T++G ++AA+V+D+ ++L L +A+ Sbjct: 162 QGTY-ILFLGVALSVTAFPVLARILAELKLINTEIGRISMSAALVNDMFAWILLALAIAL 220 Query: 168 SSRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIML-- 225 + K + +++ A+F + + + P + ++ + E + F I ++L Sbjct: 221 AESDKTSFASL-WVMISSAVFIAVCVFVVRPGIAWII---RKTPEGENFSEFHICLILTG 276 Query: 226 --IFAYLAEKFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETD 283 I ++ + + GA++ GL++ + +K+ L +P+F G++T+ Sbjct: 277 VMISGFITDAIGTHSVFGAFVFGLVIPNGPLGLTLIEKLEDFVSGLLLPLFFAISGLKTN 336 Query: 284 IRVLTHAGVFALVYSLI--AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIA 341 I + + ++ +I A GK+IG A E I +G+ + + V +I+ Sbjct: 337 IAAIQGPATWLTLFLVIFLACAGKVIGTVIVAFFHGMPVREGITLGLLLNTKGLVEMIVL 396 Query: 342 NVGLKEGILTRGDLAVPVTM-VVITTLITPFL 372 NVG + +L A V + +V+T +ITP + Sbjct: 397 NVGKDQKVLDDETFATMVLVALVMTGVITPIV 428 >dbj|BAB06563.1| (AP001516) Na+/H+ antiporter [Bacillus halodurans] Length = 686 Score = 125 bits (311), Expect = 8e-28 Identities = 96/377 (25%), Positives = 190/377 (49%), Gaps = 14/377 (3%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVML 64 L AI +V+ + L RL P +G +L GV+IGP+ +++ + LL +G++ + Sbjct: 11 LIFAIAMVVFFVAPLLMSRLRIPGIIGLILAGVVIGPNGFALLDRDPTIVLLGTVGLLYI 70 Query: 65 LFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATS 124 +F+AGLE D+E FK + + + +PFL G + + + G+ + A+ +L + + Sbjct: 71 IFIAGLEIDLEGFKKYRNRSVLFGTLSFTIPFLFGLVFTFILGFSTPAAILLASILGSHT 130 Query: 125 VGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLE 184 + L I + + + TT + I+ D L +++L +VA S +G++ I + Sbjct: 131 L-LAYPIASRLGISKDRGVTTAVGGTIMTDTLALLVLA-IVAGSMQGELNSTFWFTIAVS 188 Query: 185 VAIFFILGILIGHPLVKEVL-TLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAY 243 + ++ + +++ L K T+S L F + I+ + AY A L I GA+ Sbjct: 189 LVLYVAITLILIPILAKSFFRTMSSEGALE---FIFVMSILFVTAYGATLAGLEPIIGAF 245 Query: 244 LAGLLVS--MTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVL---THAGVFALVYS 298 LAGL ++ + E S + ++I +G +LFIP FL+S+G+ DIRVL A + A + Sbjct: 246 LAGLALNRFILEHS-PLMNRIKFVGNALFIPFFLLSVGMLMDIRVLLGDPSAWLLAALVV 304 Query: 299 LIAVVGKIIGCGFGALVARFKPIEAIQVGIGM-IPRMEVALIIANVGLKEGILTRGDLAV 357 + +GK + + + ++ I++ G+ +P+ L VG G+ + Sbjct: 305 IFVQLGKFLAAFISGKLYNYS-MDQIKLMFGLSVPQAAATLAATLVGFDLGLFDSAVVNA 363 Query: 358 PVTMVVITTLITPFLLK 374 + M+++T ++ P++++ Sbjct: 364 VIVMILVTCMVGPYVVE 380 >pir||T50062 Probable K+/H+-antiporter [imported] - fission yeast (Schizosaccharomyces pombe) >gi|7160220|emb|CAB76234.1| (AL157994) Probable K+/H+-antiporter [Schizosaccharomyces pombe] Length = 898 Score = 121 bits (301), Expect = 1e-26 Identities = 103/393 (26%), Positives = 191/393 (48%), Gaps = 24/393 (6%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSL-------LDVVEYGSEV---R 54 ++ II+ + ++ L P + +++GG+++GP++ LD + S + Sbjct: 35 VQAIIIIALCRLIHIPLSFLQQPRVIAEIIGGIVLGPTVMGRIPKFLDYIFPTSSMGPLN 94 Query: 55 LLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSV-LHGYGSLK- 112 L+S LG+V+ LF+ G+E D+ +V V + +PF G +S L+ + + + Sbjct: 95 LVSNLGLVLFLFVIGMEVDLRVLVLNYKVTLLVTVFSIVIPFGAGAGISAGLYKFTTREF 154 Query: 113 -----ALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAM 167 LF ++ T+ + IL ++ L +VG +L+A I +DV+G ++L L V + Sbjct: 155 EFGKFLLFISTAMSITAFPVLARILSELHLLHKRVGVIVLSAGIGNDVIGWILLALSVTL 214 Query: 168 SSRGKVEVEDIEIILLEVAIFFILGILIGHPLV--KEVLTLSERITLPETVTTFAIVIML 225 + G V + I+LL + L I I PLV V T S + E+ + ++L Sbjct: 215 VNSGS-GVRAVYILLLALGWCLFLFIAI-KPLVYLLAVKTRSLKDKPSESFICIVLSMVL 272 Query: 226 IFAYLAEKFQLAGITGAYLAGLLV-SMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDI 284 + A+ + + I G +L G ++ + + KIT+KI + LF+P++ S G++T+I Sbjct: 273 VSAFFTDIIGIHPIFGGFLVGTIIPHENDLTVKITEKIEDLVNCLFLPLYFASSGLKTNI 332 Query: 285 RVLTHAGVFALVYSLI--AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIAN 342 L ++ I A+ K+ A + + +++ VG M + V LI+ N Sbjct: 333 STLNTGKIWGYTIGTICVAIASKMGSSMLAARILKMPWSDSLVVGSLMSCKGLVELIVLN 392 Query: 343 VGLKEGILTRGDLAVPVTMVVITTLITPFLLKW 375 +GL GIL ++ V M VITT +T + K+ Sbjct: 393 IGLSTGILNETIFSMFVFMAVITTFVTTPMTKF 425 >gi|11497833 Na+/H+ antiporter (napA-1) [Archaeoglobus fulgidus] >gi|7451786|pir||A69277 Na+/H+ antiporter (napA-1) homolog - Archaeoglobus fulgidus >gi|2650426|gb|AAB91016.1| (AE001091) Na+/H+ antiporter (napA-1) [Archaeoglobus fulgidus] Length = 377 Score = 120 bits (299), Expect = 2e-26 Identities = 98/382 (25%), Positives = 185/382 (47%), Gaps = 17/382 (4%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 +E F +A+I + A I ++ +L P + +++ G+I G S L+V+ + LS G Sbjct: 4 VEQFATIALISLTAFISPLIADKLRVPVVVLEIVLGMIFGVSFLNVIYASEWLSFLSLFG 63 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 ++ L+FLAGLE D + G +VA + L ++ L G LF+ +L Sbjct: 64 LIFLMFLAGLEIDADVVLKSGHLKRVVAFFA--LSLALSVALTALMGLN----LFYAIIL 117 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 T +VG+ S+L ++ + G + A+V D + +L++ G ++V + Sbjct: 118 TNVAVGVVVSVLREIGLEKEDFGQLNIVTALVSDFSTMFLLSIYFI---TGYLQVAFAFL 174 Query: 181 ILLEVAIFFILG-ILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGI 239 I+L + G ++I H + ++ E ++ IM++F L+ + I Sbjct: 175 IILVFLAAYRFGKLVIWH--FPDFISRWFSDEPSEIGVRGSLAIMILFVGLSSLLGVEAI 232 Query: 240 TGAYLAGLLVSMT-EGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGV-FALVY 297 GA+LAG+L+S+T G +K+ DK+ +G+ FIPIF + G E +I T AG + Sbjct: 233 LGAFLAGVLLSITFRGGKKLYDKLYGMGFGFFIPIFFIKTGSELNI---TQAGEGIGFIL 289 Query: 298 SLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAV 357 L+AV + G + F AI +G+ ++ + + +G+ G++T + Sbjct: 290 LLLAVSVAVKGIPSLIFASNFGLRRAISMGMLQSTKLSLTIAGVAIGVSSGVITEFESTA 349 Query: 358 PVTMVVITTLITPFLLKWAFSK 379 VT +I+ L++P L ++ + + Sbjct: 350 LVTFTIISCLLSPTLFRFLYPR 371 >gb|AAF69026.1| (AF182516) unknown [Pseudomonas putida] Length = 390 Score = 114 bits (282), Expect = 2e-24 Identities = 99/374 (26%), Positives = 178/374 (47%), Gaps = 12/374 (3%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVV 62 VFL LA++L++ L+ RL A G LL G++IGPS+ ++ V LSE+GVV Sbjct: 5 VFL-LAVVLLVP-----LAQRLKMGAVPGYLLAGILIGPSVFGLLGNPDNVARLSEMGVV 58 Query: 63 MLLFLAGLETDVEEFKHVGLSAFIVAVMGV-FVPFLLGYLVSVLHGYGSLKALFFGGVLT 121 MLLF+ GLE + + + F V + V LLG L L A+ G L Sbjct: 59 MLLFVIGLELSPKRLWTMRRALFGVGSLQVGLTAVLLGLLAFWLFDQSKPAAIVLGLGLA 118 Query: 122 ATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI- 180 +S +L + K L G +A + D+ I ++ ++ + G V D Sbjct: 119 LSSTAFGLQVLAERKDLGKPHGRMAVAILLFQDIAAIPLIAVVPLLG--GDVSTADEGAW 176 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 LL V + + I+ G L+ + + LPE T A++++L A+L E ++ Sbjct: 177 PLLAVVVGIGVLIVFGRYLLTPIFKWTVGSGLPELSTATALLVVLGTAWLMEHVGVSMAL 236 Query: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 GA+LAG+L++ + ++ +I I LF+ +F V +G+ D+R+L + L +L+ Sbjct: 237 GAFLAGVLMAESPFRHELETQIEPI-KGLFLGLFFVGVGMSADLRLLFGMPLMVLGLTLL 295 Query: 301 AVVGKI-IGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPV 359 V K+ + G G + +A+ +G+ + E ++ + L+ +LT+ + V Sbjct: 296 LVAIKLPLLYGLGRTMGGLNKSQALCLGVVLASGGEFXFVVFKLALEHQVLTQAVHDLLV 355 Query: 360 TMVVITTLITPFLL 373 + ++ + P ++ Sbjct: 356 LAITLSMAVVPLVM 369 >pir||C83496 glutathione-regulated potassium-efflux system protein KefB PA1207 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9947134|gb|AAG04596.1|AE004550_12 (AE004550) glutathione-regulated potassium-efflux system protein KefB [Pseudomonas aeruginosa] Length = 613 Score = 112 bits (278), Expect = 6e-24 Identities = 97/381 (25%), Positives = 186/381 (48%), Gaps = 20/381 (5%) Query: 4 FLELAIILVIAKIFGY-LSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVV 62 FL+ ++ +IA +F L+ RL A LG LL GV+IGPS+L +V+ V +SE+GVV Sbjct: 7 FLQSGVVFLIAAVFMVPLAKRLQLGAVLGYLLAGVLIGPSVLGLVDNPESVAQISEMGVV 66 Query: 63 MLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVL---HGYGSLKALFFGGV 119 +LLF+ GLE + S F V ++ V + L+ V+++ S L G Sbjct: 67 LLLFIIGLELSPRRLWVMRKSVFGVGLLQVLLTGLVIGTVALVGFDQPVNSAVVLGLGLA 126 Query: 120 LTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMS-----SRGKVE 174 L++T+ GL IL + K+L G A + D+ I ++ ++ +S + G Sbjct: 127 LSSTAFGL--QILAERKELTQPHGRLAFAILLFQDIAAIPLIAMIPLLSGAHSDAGGSEL 184 Query: 175 VEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKF 234 + ++++ A+ ++ G L++ V + + L + T A+++++ A L E Sbjct: 185 TQTLKVVGSIAAV-----VVGGRYLLRPVFRIVAQTKLQDMSTATALLVVMGTALLMELA 239 Query: 235 QLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAG--V 292 ++ GA+LAGLL++ +E ++ +I L + +F +S+G+ DI +L + V Sbjct: 240 GVSMALGAFLAGLLLADSEYRHELEAQIEPF-KGLLLGLFFISVGMSADISLLLKSPWMV 298 Query: 293 FALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTR 352 L LIA+ ++ G + A+++G+ + E A ++ + +G+ Sbjct: 299 LGLTVLLIALKAPVL-YFVGRISGGLDKASALRLGVVLAAGGEFAFVVFKMARDQGLFQN 357 Query: 353 GDLAVPVTMVVITTLITPFLL 373 + V + ++ +TP L+ Sbjct: 358 DLHNLLVLSITLSMALTPLLV 378 >pir||A69845 Na+/H+ antiporter homolog yjbQ - Bacillus subtilis >gi|2633518|emb|CAB13021.1| (Z99110) similar to Na+/H+ antiporter [Bacillus subtilis] Length = 614 Score = 111 bits (274), Expect = 2e-23 Identities = 91/392 (23%), Positives = 183/392 (46%), Gaps = 25/392 (6%) Query: 7 LAIILVIAKIFGYLSVR--LGFPAALGQLLGGVIIGPSLLD-VVEYGSEVRLLSELGVVM 63 L ++L++A + L R L P + +++ G+IIG S L+ VVE + ++ LS LG + Sbjct: 9 LVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIGKSGLNLVVEGDTWLQTLSMLGFIF 68 Query: 64 LLFLAGLETDVEEFKHVGLSAFIV-------AVMGVFVPFLLGYLVSVLHGYGSLKALFF 116 L+FL+GLE D F+ F+ V F+ +++S+L YG + A F Sbjct: 69 LMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFAAASVIFVGIFILSLLLSYGFVLAGFI 128 Query: 117 GG------VLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSR 170 +++ S+G+ L + + + + +G IL A++ D+ +++L + ++ Sbjct: 129 QNAFLMTLIISTISLGVVVPTLKEERIMNSNIGQIILLVAVIADLATMILLAVFSSLYGE 188 Query: 171 GKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYL 230 + + I+ + + G + H V ++S+ T F ++I+L+ L Sbjct: 189 DSGNMWLLMILFAAGVVLYFFGRVFKHRSF--VQSMSKGTIQIGTRAIFTLIIVLVA--L 244 Query: 231 AEKFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHA 290 +E I GA+LAG+LVS+ ++++ ++ + GY IPIF V +G++ DI L Sbjct: 245 SESLGAENILGAFLAGVLVSLLSPNKELVQQLDSFGYGFLIPIFFVMVGVKLDIWTLFQD 304 Query: 291 GVFALVYSLI---AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKE 347 ++ L+ +V KII + L + G + + + + A +G + Sbjct: 305 KTILIMIPLLLLALLVSKIIPVMY--LKKWYDNRTIFASGFLLTSTLSLVIAAATIGQQL 362 Query: 348 GILTRGDLAVPVTMVVITTLITPFLLKWAFSK 379 +++ + + VI ++ TP K + + Sbjct: 363 HVISTNMSGALILVAVIASIFTPICFKKLYKR 394 >pir||D71642 glutathione-regulated potassium-efflux system protein kefb (kefB) RP810 - Rickettsia prowazekii >gi|3861337|emb|CAA15236.1| (AJ235273) GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYSTEM PROTEIN KEFB (kefB) [Rickettsia prowazekii] Length = 575 Score = 111 bits (274), Expect = 2e-23 Identities = 92/373 (24%), Positives = 166/373 (43%), Gaps = 5/373 (1%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVV 62 + + + I+L A + R LG L+ G IG L +V Y + +LL ELGVV Sbjct: 5 ILINVIILLGTAVFIVAILKRFRLSPVLGYLIAGAAIGDHGLKIVTY-DQTKLLGELGVV 63 Query: 63 MLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTA 122 LLF GLE E K + F + + V ++ VL S A+ GG L Sbjct: 64 FLLFAIGLELSFERLKAMRRYVFGLGSLQVLTTAIVIAGAMVLIDGNSSAAIITGGGLAL 123 Query: 123 TSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVE-DIEII 181 +S L ++ + + T++G LA ++ D+ + +L ++ ++S K + + I Sbjct: 124 SSTALVMQVIDENRSQSTQIGRISLAILLLQDLAVVPLLVIVPLLASNNKASLAVALGIA 183 Query: 182 LLEVAIFFILGILIGHPLVKEVLTL--SERITLPETVTTFAIVIMLIFAYLAEKFQLAGI 239 L+ + ++G L++ V + SE E + ++I+L A+ E F L+ Sbjct: 184 FLKAVTALLTIFIVGRVLLRPVFSFISSESNNTSELPISMTLLIVLSAAWATETFGLSLA 243 Query: 240 TGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSL 299 GA++AG+LV+ TE + + I SLF+ +F +++G+ D + L S+ Sbjct: 244 LGAFVAGVLVAETEFRLQAEESIYPF-KSLFLGLFFMTVGMNIDALEMYEKISHILTLSI 302 Query: 300 IAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPV 359 + K + ++ F A G+ + E I+ ++G G+L + + Sbjct: 303 ALICIKTLIITAFCILFGFNKGVAFYSGLLLSQGGEFGFILFSLGKDSGVLEESTADILL 362 Query: 360 TMVVITTLITPFL 372 +V T +TP L Sbjct: 363 LVVTFTMALTPLL 375 >sp|P39830|YBAL_ECOLI HYPOTHETICAL 59.4 KD PROTEIN IN GSK-FSR INTERGENIC REGION >gi|7444646|pir||E64778 probable membrane protein ybaL - Escherichia coli >gi|1773160|gb|AAB40232.1| (U82664) similar to Y. enterocolitica RosB [Escherichia coli] >gi|1786685|gb|AAC73580.1| (AE000154) putative transport protein [Escherichia coli K12] Length = 558 Score = 106 bits (263), Expect = 3e-22 Identities = 92/370 (24%), Positives = 169/370 (44%), Gaps = 9/370 (2%) Query: 11 LVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLAGL 70 LV+A I G L+ +L +G LL GV+ GP V L+ELGV++L+F GL Sbjct: 15 LVLAFILGMLANKLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGL 74 Query: 71 ETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVGLTTS 130 +++ V A A+ + V LLG +S + G+ + + FG L+ S + Sbjct: 75 HFSLKDLMAVKAIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLR 134 Query: 131 ILMDMKKLRTKVGTTILAAAIVDD---VLGIVILTLLVAMSSRGKVE----VEDIEIILL 183 L + + + ++ G + IV+D VL +V+L + M +G V D+ I + Sbjct: 135 ALEERQLIDSQRGQIAIGWLIVEDLVMVLTLVLLPAVAGMMEQGDVGFATLAVDMGITIG 194 Query: 184 EVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLA-EKFQLAGITGA 242 +V F + +L+G LV ++ S E T + + L A+ A E F ++ GA Sbjct: 195 KVIAFIAIMMLVGRRLVPWIMARSAATGSRELFTLSVLALALGVAFGAVELFDVSFALGA 254 Query: 243 YLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAV 302 + AG++++ +E S + + + F +F VS+G+ D +L + L I + Sbjct: 255 FFAGMVLNESELSHRAAHDTLPL-RDAFAVLFFVSVGMLFDPLILIQQPLAVLATLAIIL 313 Query: 303 VGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMV 362 GK + F + A+ + + E A I+A +G+ +L + + + Sbjct: 314 FGKSLAAFFLVRLFGHSQRTALTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGA 373 Query: 363 VITTLITPFL 372 +++ ++ P L Sbjct: 374 ILSIMLNPVL 383 >gb|AAK40705.1| Na(+)/H(+) antiporter [Sulfolobus solfataricus] Length = 505 Score = 104 bits (258), Expect = 1e-21 Identities = 81/374 (21%), Positives = 168/374 (44%), Gaps = 16/374 (4%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVML 64 L L I+L+ AKI + R+G +G +L G+++G + V++ + ++ LG+V L Sbjct: 10 LYLGIMLIAAKISEEIFRRIGLVTFVGPILMGILLGNGVFGVIQINEIISFITSLGIVFL 69 Query: 65 LFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATS 124 LFLAG E + + F+ ++ +PF + + + G+ + L L +S Sbjct: 70 LFLAGAE-EFNVENRPNANVFLAVILESIIPFSVILVAIYIIGFKNYLILIV--PLAMSS 126 Query: 125 VGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLE 184 G + +LMD+K ++ I I+ +++ +++ +L+ S +I I ++E Sbjct: 127 AGPLSRMLMDVKISDNRISNLIFQQVILIEIIFVILFAILLKTS--------EILITIIE 178 Query: 185 VAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYL 244 + + F I+ G L K + + E I I+LI YLAE ++ A+ Sbjct: 179 IFLVFAFTIMFGRTLAKILEKIEYYFKAREIEFASLIAIILIIGYLAELYKFNSAISAFF 238 Query: 245 AGLLV-SMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVV 303 G+L+ + ++ +++ Y F P+F + IG+ ++ +F+L++ + + Sbjct: 239 LGILLKDYLKDRPELLERLHAFTYGFFEPLFFLGIGLYV-TKINASIILFSLLFFSLIIA 297 Query: 304 GKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVV 363 K + G + ++ I+ G + V + GL G + + + + Sbjct: 298 SKFLA---GFISSKILNIKGKINGFATSVKGGVDSSLLLTGLTLGYINEFMYSFSILAIS 354 Query: 364 ITTLITPFLLKWAF 377 ++ LI P L + F Sbjct: 355 LSALIVPLLFQINF 368 >pir||C70474 Na+/H+-exchanging protein - Aquifex aeolicus >gi|2984253|gb|AAC07780.1| (AE000768) Na(+)/H(+) antiporter [Aquifex aeolicus] Length = 422 Score = 104 bits (256), Expect = 2e-21 Identities = 68/334 (20%), Positives = 156/334 (46%), Gaps = 5/334 (1%) Query: 9 IILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLA 68 ++L+ IFGY ++ P+ + ++ G + P L E + + G+++L F Sbjct: 16 LVLLFMFIFGYTFQKVNIPSIIAFMIIGFLAQP--LVPPEKIKDFEIFKHAGIILLFFFI 73 Query: 69 GLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVGLT 128 GLE E + + L A+ + F+ ++++ G+ + AL V +S + Sbjct: 74 GLEYSFERLRTM-LGAWKTGSIDFVFNFIPPFIIAYAFGFDLITALILAAVFYPSSTSII 132 Query: 129 TSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVAIF 188 +LMD K++ + ++ I +D++ I++LT+++ + G +E I + L+++ + Sbjct: 133 AKLLMDYKRIASPEAELLIGILIFEDLVAILLLTIIIPLKEAGSIEFTTIPVSLVKLGVA 192 Query: 189 FILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLL 248 F+L LI L+ ++ +R++ + F + ++L + ++ GA+L G++ Sbjct: 193 FLLFWLIYKYLIPKINAWLDRVSEEDIFIFFTLGLVLSIGTIFHSLGISEALGAFLLGVI 252 Query: 249 VSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVVGKIIG 308 V T+ I ++ + L + +F ET + + G+ L+ ++ ++ KII Sbjct: 253 VPETKVLENIEKQLSDL-KELSMGLFFFFFAYETQLTKPENLGLLILLI-VLGIILKIIS 310 Query: 309 CGFGALVARFKPIEAIQVGIGMIPRMEVALIIAN 342 V K ++ + +PR E ++I+ + Sbjct: 311 TYLAGYVFGLKKKSRLRASLSFVPRGEFSVIMTS 344 >pir||B69146 gluthatione-regulated K+/H+ antiporter - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2621417|gb|AAB84864.1| (AE000821) gluthatione-regulated K+/H+ antiporter [Methanobacterium thermoautotrophicum] Length = 512 Score = 103 bits (254), Expect = 4e-21 Identities = 87/342 (25%), Positives = 159/342 (46%), Gaps = 11/342 (3%) Query: 36 GVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVP 95 GVI GPS+L V GS + L+ELGV++LLF GLE E F +A I + + + Sbjct: 3 GVIAGPSVLGAVSSGS-IESLAELGVILLLFTIGLEMSAERFGEFRRTALIGGTLQICLT 61 Query: 96 FLLGYLVSVLHGYGSLKALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDV 155 + +++++ G KA+F G +++ +S + +L D + G LA I DV Sbjct: 62 VSVVTILTMVLGLSPGKAVFLGFLISLSSTAVVLKVLQDFHETEAPHGQASLAILIFQDV 121 Query: 156 LGIVILTLLVAMSSRGKVEVEDIEII--LLEVAIFFILGILIGHPLVKEVLTLSERITLP 213 + +++ + G V + + LL IG LV + + Sbjct: 122 AAV---PMILTVPFLGGVVGDPSSALGTLLTAGAVLPWEPCIGKVLVPRLFDVVAATGSR 178 Query: 214 ETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPI 273 E I++ +L + L+ GA+L G +V+ TE + + I+ +F+ Sbjct: 179 EIFLLTVILVCASVTWLTGEVGLSPALGAFLVGSIVANTEYAHRAQGTILPF-QEVFLSF 237 Query: 274 FLVSIGIETDIR-VLTHAGVFALVYSLIAVVG-KIIGCGFGALVARFKPIEAIQVGIGMI 331 F VS+G+ D+R L H ++ +V ++I V+ K++ V + + +G+ + Sbjct: 238 FFVSLGMLLDLRFFLDH--IYLIVLAVIGVLMIKVVMNSLVGFVMGYSARVVVLLGLVLA 295 Query: 332 PRMEVALIIANVGLKEGILTRGDLAVPVTMVVITTLITPFLL 373 E + I++ GL+ G++ R +++ +IT ITPFL+ Sbjct: 296 QIGEFSFILSETGLRYGLMDRLTFQAFLSVSLITMAITPFLI 337 >pir||G75282 probable glutathione-regulated potassium-efflux system protein KefB - Deinococcus radiodurans (strain R1) >gi|6460182|gb|AAF11914.1|AE002067_6 (AE002067) glutathione-regulated potassium-efflux system protein KefB, putative [Deinococcus radiodurans] Length = 575 Score = 102 bits (251), Expect = 9e-21 Identities = 80/306 (26%), Positives = 145/306 (47%), Gaps = 10/306 (3%) Query: 6 ELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLL 65 +L ++L++A + S RLG +G L GV+ GPS L +++ + + SE+GV++LL Sbjct: 38 QLTLLLLVAGATAFASFRLGLVPIIGFLFAGVLAGPSALGIIDDPALIGAASEIGVMLLL 97 Query: 66 FLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSV 125 F G+E +++ + F+ + V + V + G A+F G +L+ +S Sbjct: 98 FTIGIEFSLDKLARIFRLIFVGGGLQVLLTVAAVTGVLLAFGVSLPNAVFTGFLLSLSST 157 Query: 126 GLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEV 185 + T IL + + G L I D L +V++ LLV M + + + LL+ Sbjct: 158 AIVTKILESRGGVGSPTGQASLGILIFQD-LAVVVMVLLVPMLAGQGGGAGGLVVALLKA 216 Query: 186 AIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLA 245 +L+ +V ++L + R E + + AYL ++ GA+LA Sbjct: 217 GGIVAAVLLLARRVVPKLLEVVARTCSQEIFLLSTLSLCFATAYLTSLAGVSLALGAFLA 276 Query: 246 GLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVL-TH-------AGVFALVY 297 GLLVS + ++ +I+ + LF F +S+G++ D+ L TH VFA++ Sbjct: 277 GLLVSESRFGQQAFGEILPL-QILFSAAFFLSVGLQLDLGFLWTHLPLVLGAVAVFAVLK 335 Query: 298 SLIAVV 303 +L A + Sbjct: 336 ALAAAL 341 >pir||G75431 probable Na+/H+ antiporter - Deinococcus radiodurans (strain R1) >gi|6458886|gb|AAF10721.1|AE001964_5 (AE001964) Na+/H+ antiporter, putative [Deinococcus radiodurans] Length = 383 Score = 101 bits (250), Expect = 1e-20 Identities = 92/378 (24%), Positives = 180/378 (47%), Gaps = 18/378 (4%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGP--SLLDVVEYGSEVRLLSELG 60 +FLEL +++ + G + RLG L+ G+ +G L D E + +E+G Sbjct: 5 LFLELGTVILALALVGRAAGRLGITPIPLYLMAGIGLGTFMHLDDTAE--KFIHTGAEIG 62 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 ++LLF+ GLE +E + + + ++ + + F G + L G L + GG+ Sbjct: 63 AILLLFILGLEYTSDELRTNLKANRQIGLIDLALNFTPGVVAGALLGLPPLAWVLLGGIT 122 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 TS G+ + IL D+ +L + ILA +++DV+ L ++ A+ G + + + Sbjct: 123 FLTSSGIASKILSDLGRLGNRETPIILAVCVIEDVVMAFYLPVVAALLIGGSLLSVGVNL 182 Query: 181 ILLEVA--IFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAG 238 L A + F L + GH VL+ + ET+ + ++L+ A A+ +++ Sbjct: 183 ALALTAFGVTFFLAMRYGH-----VLSRVLNVPSDETLLLGVLGLVLVVAGAADLLKVSA 237 Query: 239 ITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYS 298 GA+L G+ +S E + + +I + LF +F + G++ D+ + + A + + Sbjct: 238 AIGAFLVGIALS-GEVAHRARQQIEPL-RDLFAAVFFLFFGLQLDLAEVPEVLLPAALLA 295 Query: 299 LIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGIL-TRGDLAV 357 ++ + K + +GA A + + G +I R E +++IA +GL G+ G LA Sbjct: 296 VVTSITKFLVGWYGARRAGVQSRGRYRAGTTLIARGEFSILIAGLGL--GLAPVLGPLA- 352 Query: 358 PVTMVVITTLITPFLLKW 375 V++T +I P L ++ Sbjct: 353 -AVYVLLTAIIGPVLARF 369 >pir||G70337 Na+/H+-exchanging protein - Aquifex aeolicus >gi|2983090|gb|AAC06696.1| (AE000689) NA(+)/H(+) antiporter [Aquifex aeolicus] Length = 387 Score = 101 bits (248), Expect = 2e-20 Identities = 92/382 (24%), Positives = 175/382 (45%), Gaps = 13/382 (3%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVML 64 L L I+ + A + S L P +G+L+ G++IG + + + + LS+ G ++L Sbjct: 11 LFLIIVFLSAFLAPLFSRILRMPVPVGELIFGILIGNFFVGI-QVPEILNFLSDFGFLLL 69 Query: 65 LFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATS 124 +FLAGLE D + V + V + FL ++ +L G G+ A+ +L+ S Sbjct: 70 MFLAGLELDFNLIEKADKKQNAVYISYVLLIFLSAFVFGILLGIGTAPAI----ILSLIS 125 Query: 125 VGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLL-VAMSSRGKVE-VEDIEIIL 182 +GL + L DM L +L + +++ ++ LTL+ + G V ++++ +I Sbjct: 126 LGLMVATLKDMSVLEEPFAKKVLLIGVFGEIISLLALTLMEKLLHFHGFVSLIKELGVIF 185 Query: 183 LEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKF-QLAGI-- 239 + FF LG + LV + R+T E + I + L + + F +LAGI Sbjct: 186 VFFFSFF-LGFYLTRLLVWWYPEIVNRLTYEEDPSALGIRLSLFLMFTSSIFAKLAGIES 244 Query: 240 -TGAYLAGLLVSMTEGSRK-ITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVY 297 GA++AG++ S +K + +K+ +IGY IPIF + G+ ++ L A +F + Sbjct: 245 VLGAFMAGVVFSYFIREKKDLEEKLSSIGYGFLIPIFFIKTGMGMEVAGLNLAILFKVFI 304 Query: 298 SLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAV 357 L ++ + F L+A F ++ G+ + + + + + G L Sbjct: 305 FLAFMLFVRLIPSFVLLLAGFSLKDSFTAGLLLSYPFTLMVAGIEIARRGGALDEETALA 364 Query: 358 PVTMVVITTLITPFLLKWAFSK 379 ++L+ P+ K S+ Sbjct: 365 LFLTAAFSSLVFPWSAKIILSR 386 >sp|P44933|KEFX_HAEIN GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYSTEM PROTEIN (K(+)/H(+) ANTIPORTER) >gi|1075164|pir||A64102 glutathione-regulated potassium efflux system protein kefC homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573928|gb|AAC22568.1| (U32772) glutathione-regulated potassium efflux system protein (kefC) [Haemophilus influenzae Rd] Length = 618 Score = 100 bits (247), Expect = 3e-20 Identities = 87/382 (22%), Positives = 174/382 (44%), Gaps = 15/382 (3%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 M+V + LA + I +F RLG + LG L+ G +IGPS+ +V+ + V L+ELG Sbjct: 10 MKVVILLASSVTIVPLFK----RLGLGSVLGYLVAGCLIGPSVFGIVQEPTAVVHLAELG 65 Query: 61 VVMLLFLAGLETDVEEFKHV-----GLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALF 115 VVM LF+ GLE E + G V + G + F YL+ + + + Sbjct: 66 VVMFLFIIGLEMYPERLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMG 125 Query: 116 FGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEV 175 F T +S + L + T G +++ I +D+ + +L + ++ K Sbjct: 126 F----TLSSTAIVMQSLEERGLTSTSKGQRVISTLIFEDIAIVPLLASVAFLAPHSKEAT 181 Query: 176 EDIEIILLEVAIFFILGILI-GHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKF 234 + + + +A+ ++G+++ G L+ + L + + E +T A++++L A E Sbjct: 182 PHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEIG 241 Query: 235 QLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFA 294 L+ GA++AG+++S + ++ I L + +F + +G+ D+ ++ + + Sbjct: 242 GLSMAMGAFVAGVMMSESAFRHQLEADIEPF-RGLLLGLFFMGVGMSLDLHLVFNHWILL 300 Query: 295 LVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGD 354 L + ++GK A + R EAI M E A ++ + +++ + Sbjct: 301 LGIVFLYILGKASAVYIIARITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEE 360 Query: 355 LAVPVTMVVITTLITPFLLKWA 376 A V+I+ L +P + + A Sbjct: 361 QATFTAAVIISMLFSPIIAQIA 382 >dbj|BAA06982.1| (D32253) MagA [Magnetospirillum sp.] Length = 434 Score = 99.5 bits (244), Expect = 6e-20 Identities = 83/375 (22%), Positives = 177/375 (47%), Gaps = 14/375 (3%) Query: 8 AIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFL 67 AI+ + A + G + RL PA +G +L GV++GPS +V V L+E GV+MLLF+ Sbjct: 12 AIVALAAVLCGGMMTRLKQPAVVGYILAGVVLGPSGFGLVSNRDAVATLAEFGVLMLLFV 71 Query: 68 AGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYG-SL-KALFFGGVLTATSV 125 G++ D+ F V +A V+ + +G + + HG G SL A+ G + +S Sbjct: 72 IGMKLDIIRFLEVWKTAIFTTVLQ--IAGSVGTALLLRHGLGWSLGLAVVLGCAVAVSST 129 Query: 126 GLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEV 185 + +L +L T VG T L I D+ + ++ +L + ++ + + ++L Sbjct: 130 AVVIKVLESSDELDTPVGRTTLGILIAQDMAVVPMMLVLESFETKALLPADMARVVL--- 186 Query: 186 AIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLI-FAYLAEKFQLAGITGAYL 244 ++ F++ + + L ++ R++ + T + + A ++ L+ GA+L Sbjct: 187 SVLFLVLLFWWLSKRRIDLPITARLSRDSDLATLSTLAWCFGTAAISGVLDLSPAYGAFL 246 Query: 245 AGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIR-VLTHAGVFALVYSLIAVV 303 G+++ + + + IG S+ + +F +SIG+ D + + + G + +++ + Sbjct: 247 GGVVLGNSAQRDMLLKRAQPIG-SVLLMVFFLSIGLLLDFKFIWKNLGTVLTLLAMVTLF 305 Query: 304 GKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVV 363 + L + P A G+ + E + ++A G +++ + + V + V Sbjct: 306 KTALNVTALRLARQDWP-SAFLAGVALAQIGEFSFLLAETGKAVKLISAQETKLVVAVTV 364 Query: 364 ITTLITPFLLKWAFS 378 ++ +++PF W F+ Sbjct: 365 LSLVLSPF---WLFT 376 >pir||A81330 probable glutathione-regulated potassium-efflux system protein Cj1231 [imported] - Campylobacter jejuni (strain NCTC 11168) >gi|6968664|emb|CAB73485.1| (AL139077) putative glutathione-regulated potassium-efflux system protein [Campylobacter jejuni] Length = 541 Score = 99.1 bits (243), Expect = 8e-20 Identities = 91/378 (24%), Positives = 167/378 (44%), Gaps = 12/378 (3%) Query: 1 MEVFLELAIILV-IAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSEL 59 M+ FLE+ +I V IA + + + P +G + G II S + + E+ ++E Sbjct: 1 MDNFLEIFLITVAIAIVLNVIFKKFEIPTIIGYIAAGEII--SEIYHLSGKGEITHIAEF 58 Query: 60 GVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLH----GYGSLKALF 115 G+V L+F GLE FKH+ V + G G++ +L G G A Sbjct: 59 GIVFLMFTIGLEFS---FKHLMAMKQEVFLNGSLQMLTCGFVFMLLAIGILGLGDKSATI 115 Query: 116 FGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEV 175 G L +S + IL D + + G L + D+ I +L L+ SS + Sbjct: 116 VGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLVDIFSSNNQNIE 175 Query: 176 EDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQ 235 + + L+ I L IG LV + L + E + + +++ ++LA F Sbjct: 176 KLLFTSLISALILITLLFFIGKYLVDRIFRLIIHTSSQEIFISTVLFMVIGASFLANYFG 235 Query: 236 LAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFAL 295 + GA++AG L++ T+ KI ++ L + +F +++G++ + V+ + Sbjct: 236 FSYSLGAFIAGALIAETKYKHKIEADLIPF-RDLLLGLFFITVGMQIQLDVVAQNWFLII 294 Query: 296 VYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDL 355 V +L+ + K G FG L K A++ + E AL I ++ + +L Sbjct: 295 VLTLLVMALK-FGIVFGFLFLYTKKRVALKTAFAIAQIGEFALAIFSLLQAKNMLDIKTS 353 Query: 356 AVPVTMVVITTLITPFLL 373 + + + ++T +ITPF+L Sbjct: 354 QILIVVSILTMIITPFIL 371 >gb|AAD01191.1| (AF003382) KEA1 [Arabidopsis thaliana] Length = 618 Score = 98.7 bits (242), Expect = 1e-19 Identities = 97/386 (25%), Positives = 177/386 (45%), Gaps = 38/386 (9%) Query: 10 ILVIAKIFGYLSVRL-GFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLA 68 +L+ + IF L ++ G LG L G++IGP L ++ R ++E GVV+LLF Sbjct: 20 LLLASVIFVPLFQKIPGGSPVLGYLAAGILIGPYGLSIIRNVHGTRAIAEFGVVLLLFNI 79 Query: 69 GLETDVEEFKHVGLSAFIVAVMGVFV-PFLLGYLVSVLHGYGSLKALFFGGVLTATSVGL 127 GLE VE + F + V V ++G L + G A+ G L +S + Sbjct: 80 GLELSVERLSSMKKYVFGLGSAQVLVTAAVVGLLAHYVAGQAGPAAIVIGNGLALSSTAV 139 Query: 128 TTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAM----SSRGKV------EVED 177 +L + + ++ G + + D L +V+L +L+ + SS+G + E Sbjct: 140 VLQVLQERGESTSRHGRASFSVLLFQD-LAVVVLLILIPLISPNSSKGGIGFQAIAEALG 198 Query: 178 IEIILLEVAIFFIL--GILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQ 235 + + VAI I+ G L+ P+ K++ E + ++++L + L + Sbjct: 199 LAAVKAAVAITAIIAGGRLLLRPIYKQIAENRN----AEIFSANTLLVILGTSLLTARAG 254 Query: 236 LAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTH-----A 290 L+ GA+LAGLL++ TE S ++ I L + +F +++G+ D ++L Sbjct: 255 LSMALGAFLAGLLLAETEFSLQVESDIAPY-RGLLLGLFFMTVGMSIDPKLLLSNFPVIV 313 Query: 291 GVFALVY----SLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLK 346 G L+ L+ ++GK+ G I AI+VG+ + P E A + + Sbjct: 314 GTLGLLIVGKTMLVVIMGKLFGISI---------ISAIRVGLLLAPGGEFAFVAFGEAVN 364 Query: 347 EGILTRGDLAVPVTMVVITTLITPFL 372 +GI++ ++ +V I+ ITP+L Sbjct: 365 QGIMSPQLSSLLFLVVGISMAITPWL 390 >gb|AAF78418.1|AC009273_24 (AC009273) Identical to K efflux antiporter mRNA from Arabidopsis thaliana gb|AF003382. It contains a TrkA potassium uptake protein PF|02080 domain. ESTs gb|T44799, gb|AA395270 and gb|AI997899 come from this gene Length = 618 Score = 97.9 bits (240), Expect = 2e-19 Identities = 97/386 (25%), Positives = 176/386 (45%), Gaps = 38/386 (9%) Query: 10 ILVIAKIFGYLSVRL-GFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLA 68 +L+ + IF L ++ G LG L G++IGP L ++ R ++E GVV LLF Sbjct: 20 LLLASVIFVPLFQKIPGGSPVLGYLAAGILIGPYGLSIIRNVHGTRAIAEFGVVFLLFNI 79 Query: 69 GLETDVEEFKHVGLSAFIVAVMGVFV-PFLLGYLVSVLHGYGSLKALFFGGVLTATSVGL 127 GLE VE + F + V V ++G L + G A+ G L +S + Sbjct: 80 GLELSVERLSSMKKYVFGLGSAQVLVTAAVVGLLAHYVAGQAGPAAIVIGNGLALSSTAV 139 Query: 128 TTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAM----SSRGKV------EVED 177 +L + + ++ G + + D L +V+L +L+ + SS+G + E Sbjct: 140 VLQVLQERGESTSRHGRASFSVLLFQD-LAVVVLLILIPLISPNSSKGGIGFQAIAEALG 198 Query: 178 IEIILLEVAIFFIL--GILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQ 235 + + VAI I+ G L+ P+ K++ E + ++++L + L + Sbjct: 199 LAAVKAAVAITAIIAGGRLLLRPIYKQIAENRN----AEIFSANTLLVILGTSLLTARAG 254 Query: 236 LAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTH-----A 290 L+ GA+LAGLL++ TE S ++ I L + +F +++G+ D ++L Sbjct: 255 LSMALGAFLAGLLLAETEFSLQVESDIAPY-RGLLLGLFFMTVGMSIDPKLLLSNFPVIV 313 Query: 291 GVFALVY----SLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLK 346 G L+ L+ ++GK+ G I AI+VG+ + P E A + + Sbjct: 314 GTLGLLIVGKTMLVVIMGKLFGISI---------ISAIRVGLLLAPGGEFAFVAFGEAVN 364 Query: 347 EGILTRGDLAVPVTMVVITTLITPFL 372 +GI++ ++ +V I+ ITP+L Sbjct: 365 QGIMSPQLSSLLFLVVGISMAITPWL 390 >pir||E82956 probable potassium efflux transporter PA5518 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9951855|gb|AAG08903.1|AE004964_6 (AE004964) probable potassium efflux transporter [Pseudomonas aeruginosa] Length = 567 Score = 97.1 bits (238), Expect = 3e-19 Identities = 97/375 (25%), Positives = 168/375 (43%), Gaps = 10/375 (2%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLF 66 LA V+A +FG L+ RL +G LL GV+ GP V + + ++ELGV++L+F Sbjct: 10 LAAGFVLAFLFGALANRLRISPLVGYLLAGVLAGPFTPGYVADQALSQEIAELGVILLMF 69 Query: 67 LAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVG 126 GL +++ V A A++ + V LLG ++ L G+ L FG L+ S Sbjct: 70 GVGLHFSLKDLLSVKAIAIPGALVQIGVATLLGIGLAKLLGWSFGGGLVFGLSLSVASTV 129 Query: 127 LTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSR--GKVEVED------I 178 + L + L TK G + IV+D+ ++ L LL A++ GK + D + Sbjct: 130 VLLRALEQRQLLDTKRGRIAIGWLIVEDLAMVLTLVLLPALAGTLGGKTDGGDAGLLWPL 189 Query: 179 EIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAY-LAEKFQLA 237 I L +VA F L I G +V VL E T + I L AY A F ++ Sbjct: 190 LITLGKVAAFVALMIFGGRRVVPWVLERIAASGSRELFTLAVLAIALGIAYGSAVLFGVS 249 Query: 238 GITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVY 297 GA+ AG++++ +E S + + + + F +F VS+G+ + +L + L Sbjct: 250 FALGAFFAGMILNESELSHEAAENSLPL-RDAFAVLFFVSVGMLFNPMILLQEPLTVLAT 308 Query: 298 SLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAV 357 L+ V GK + A+ + + E + I+ +G+ ++ + Sbjct: 309 FLVIVFGKSVAAYLIVRAFGHPNSTALVIAASLAQIGEFSFILIGLGIGLELVPEQSRDL 368 Query: 358 PVTMVVITTLITPFL 372 + +++ L+ P L Sbjct: 369 VLAGAILSILVNPLL 383 >gb|AAC60780.1| (U46859) RosB [Yersinia enterocolitica (type 0:8)] Length = 563 Score = 96.7 bits (237), Expect = 4e-19 Identities = 89/370 (24%), Positives = 164/370 (44%), Gaps = 9/370 (2%) Query: 11 LVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLAGL 70 LV+A + G L+ RL +G L GV+ GP V S L+E+GV++L+F GL Sbjct: 15 LVLAFLLGSLAHRLRSSPLVGYLAAGVLAGPFTPGFVADTSLAPELAEIGVILLMFGVGL 74 Query: 71 ETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVGLTTS 130 +++ V A AV + V LLG +S L G+ + FG L+ S + Sbjct: 75 HFSLKDLLAVKAIAIPGAVAQIAVATLLGMGLSHLLGWDLMTGFVFGLCLSTASTVVLLR 134 Query: 131 ILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVAI--- 187 L + + + ++ G + +IV+D+ ++ L LL A + E + + E+AI Sbjct: 135 ALEERQLIDSQRGQIAIGRSIVEDLAMVLTLVLLPAFAGVMGNETTSLSQLFTELAITIG 194 Query: 188 ----FFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLA-EKFQLAGITGA 242 F L I++G LV +L + E T +V+ L AY A F ++ GA Sbjct: 195 KVIAFITLMIVVGRRLVPWILAKTASTGSRELFTLAVLVLALGIAYGAVGLFDVSFALGA 254 Query: 243 YLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAV 302 + AG++++ +E S + + + F +F VS+G+ D +L + L I + Sbjct: 255 FFAGMVLNESELSHRAAQDTLPL-RDAFAVLFFVSVGMLFDPMILLREPLAVLASLAIII 313 Query: 303 VGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMV 362 GK + + + + + I+A +G+ G+++ + + Sbjct: 314 FGKSAAAFILVRMFGHSNVYSTHHFCPWRKSVNLPFILAGLGISLGLMSEHGRNLVLAGA 373 Query: 363 VITTLITPFL 372 +++ ++ P L Sbjct: 374 ILSIMLNPLL 383 >pir||G69819 Na+/H+ antiporter homolog yhaU - Bacillus subtilis >gi|2226151|emb|CAA74453.1| (Y14080) hypothetical protein [Bacillus subtilis] >gi|2633321|emb|CAB12825.1| (Z99109) similar to Na+/H+ antiporter [Bacillus subtilis] Length = 408 Score = 96.7 bits (237), Expect = 4e-19 Identities = 80/351 (22%), Positives = 149/351 (41%), Gaps = 9/351 (2%) Query: 6 ELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSL-------LDVVEYGSEVRLLSE 58 E+ LV+ I ++ ++ F ++ G+++GP L ++ + Sbjct: 10 EVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHAPKMGIIDLTFIQSSEIIEFFGR 69 Query: 59 LGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGG 118 +GV+ LLF GLE V + G S + + + + F LG L + G+ L+ L G Sbjct: 70 MGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILINFSLGLLYGFITGFSFLEVLILAG 129 Query: 119 VLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDI 178 V+T +S + +L+D+K+ IL + +D+ V L+++ + V Sbjct: 130 VITISSSAIVAKVLVDLKRTANPETELILGIIMFEDIFLAVYLSVVSGLILGDATSVGSA 189 Query: 179 EIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAG 238 + +L +A ++L I + +L I E + A +E +A Sbjct: 190 LLSIL-IAFGYMLLFFIAARKLPPLLNKLLDIRSNEVFIIVIFAALFFIAGFSETIHVAE 248 Query: 239 ITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYS 298 GA L GL+ S TE S +I ++ F +F S G+ D L A AL Sbjct: 249 AIGALLLGLVFSETEHSDRIEHLVVPF-RDFFGAMFFFSFGLSIDPFSLGEAVWLALGAV 307 Query: 299 LIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGI 349 ++ ++G I A + +G+ ++ R E ++I+AN+G+ G+ Sbjct: 308 ILTILGNFIAGMVAGRRAGLSHKASSNIGLTIVSRGEFSIIVANLGIAGGL 358 >pir||B82056 glutathione-regulated potassium-efflux system protein KefB VC2606 [imported] - Vibrio cholerae (group O1 strain N16961) >gi|9657194|gb|AAF95747.1| (AE004327) glutathione-regulated potassium-efflux system protein KefB [Vibrio cholerae] Length = 656 Score = 96.0 bits (235), Expect = 7e-19 Identities = 95/377 (25%), Positives = 174/377 (45%), Gaps = 18/377 (4%) Query: 4 FLELAIILVIAKIFGY-LSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVV 62 FL +++ + A + L+ R G + LG LL G+ IGP L ++ + +E GVV Sbjct: 64 FLSSSVVFLSAAVIAVPLAQRAGLGSVLGYLLAGIAIGPWGLGLIRDVQAIMHFAEFGVV 123 Query: 63 MLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSV--LHGYGSLKALFFGGVL 120 +LLFL GLE + + K L I+ + G V L SV L G AL G L Sbjct: 124 LLLFLIGLELNPK--KLWNLRGPILGLGGAQVVVTTAVLSSVAYLLGVSWQSALVIGMAL 181 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEI 180 +S + ++ + RT+ G + A + D+ I +L LL ++ + + Sbjct: 182 ALSSTAIALRVIEEHGLTRTEAGQSGFAVLLFQDIAVIPMLALLPILAGNSSGDWLNALW 241 Query: 181 ILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGIT 240 + +A + G + +PL + + R E T A+++++ A L +K L+ Sbjct: 242 MTGGIAALLLGGHFLLNPLFRYIALSGVR----ELFTVAALLLVVGIALLMQKVGLSMAL 297 Query: 241 GAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLI 300 G +LAG++++ +E ++ I L + +F +S+G+ D+ +L + + ++ Sbjct: 298 GTFLAGVILAESEFRHELEIAIDPF-KGLLLGLFFISVGMAVDVGLL----LVKPLQIML 352 Query: 301 AVVGKIIGCGFGA-LVARFKPIEA---IQVGIGMIPRMEVALIIANVGLKEGILTRGDLA 356 AV+G +I G L+AR A ++ + E A +I EG+LT ++ Sbjct: 353 AVLGLVIVKGLVLYLLARLSGTVAKARSKMAAILSQGGEFAFVIFTAASAEGLLTASQVS 412 Query: 357 VPVTMVVITTLITPFLL 373 + +V ++ + TP LL Sbjct: 413 FLLVVVSLSMVTTPLLL 429 >dbj|BAB11240.1| (AB010074) potassium/proton antiporter-like protein [Arabidopsis thaliana] Length = 562 Score = 94.8 bits (232), Expect = 1e-18 Identities = 88/381 (23%), Positives = 178/381 (46%), Gaps = 11/381 (2%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 + + +L +I+V A I G + LG P +G LL G IIGP L + +V +++ G Sbjct: 152 LRLISDLVVIIVFAAIGGIVFSCLGQPVIVGYLLAGSIIGPGGLKFISEMVQVETVAQFG 211 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 VV LLF GLE + + K VG A + ++ + + L + ++L G + +F G L Sbjct: 212 VVFLLFALGLEFSMTKLKVVGPVAVLGGLLQIVLLMFLCGVTALLCGARLSEGIFVGAFL 271 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDD-VLGIVILTLLVAMSSRGKVE-VEDI 178 + +S + L++ + G + I D V+G++ L V + G ++ + + Sbjct: 272 SMSSTAVVVKFLVERNSTSSLHGQVTIGILIFQDCVVGLLFALLPVLGGNSGLLQGIISM 331 Query: 179 EIILLEVAIFFILGILIGHPLVKEVLTLSERIT--LPETVTTFAIVIMLIFAYLAEKFQL 236 +LL ++I+ + L+ V L L +++ E A+ L+ A+ ++K L Sbjct: 332 GKLLLILSIYLTVASLLTWSFVPRFLKLMIQLSSQTNELYQLAAVAFCLLSAWCSDKLGL 391 Query: 237 AGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALV 296 + G+++AG+++S TE ++ ++++ + F IG+ ++ L + V L+ Sbjct: 392 SLELGSFVAGVMLSTTEFAQHTLEQVLILNSGRFC-FASTCIGMLINVHFLWN-HVDILL 449 Query: 297 YSLIAVVGKIIGCGFGALVA---RFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRG 353 S+I V+ +I A+V R+ + VG+ + E A ++ + ++ Sbjct: 450 ASVILVI--VIKTAIAAVVVKAFRYNMRISFHVGVLLAQIGEFAFVLLSRASNLHVIEGK 507 Query: 354 DLAVPVTMVVITTLITPFLLK 374 + + ++ + TP L K Sbjct: 508 MYLLLLGTTALSLVTTPLLFK 528 >sp|P03819|KEFC_ECOLI GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYSTEM PROTEIN KEFC (K(+)/H(+) ANTIPORTER) >gi|2145008|pir||QQECRD glutathione-regulated potassium efflux system protein kefC [validated] - Escherichia coli >gi|41875|emb|CAA40066.1| (X56742) KefC potassium efflux system [Escherichia coli] >gi|216472|dbj|BAA01323.1| (D10483) kefc potassium efflux system [Escherichia coli] >gi|1786232|gb|AAC73158.1| (AE000115) K+ efflux antiporter, glutathione-regulated [Escherichia coli K12] Length = 620 Score = 94.4 bits (231), Expect = 2e-18 Identities = 74/285 (25%), Positives = 134/285 (46%), Gaps = 4/285 (1%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVML 64 ++ I L A + ++VRLG + LG L+ G IIGP L +V + +E+GVV++ Sbjct: 7 IQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLM 66 Query: 65 LFLAGLETDVEEFKHVGLSAF-IVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTAT 123 LF+ GLE D + + + F A+ V LLG L +L G A G L + Sbjct: 67 LFIIGLELDPQRLWKLRAAVFGCGALQMVICGGLLG-LFCMLLGLRWQVAELIGMTLALS 125 Query: 124 SVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLL-VAMSSRGKVEVEDIEIIL 182 S + + + + T++G + A + D+ I ++ ++ + +S + + Sbjct: 126 STAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAIPLVAMIPLLATSSASTTMGAFALSA 185 Query: 183 LEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGA 242 L+VA +L +L+G + + L R L E + A+ ++ F L E+ L+ GA Sbjct: 186 LKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGA 245 Query: 243 YLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVL 287 +LAG+L++ +E + I L + +F + +G+ D L Sbjct: 246 FLAGVLLASSEYRHALESDIEPF-KGLLLGLFFIGVGMSIDFGTL 289 >pir||G64578 glutathione-regulated potassium-efflux system protein - Helicobacter pylori (strain 26695) >gi|2313582|gb|AAD07539.1| (AE000562) glutathione-regulated potassium-efflux system protein (kefB) [Helicobacter pylori 26695] Length = 416 Score = 93.6 bits (229), Expect = 3e-18 Identities = 90/396 (22%), Positives = 182/396 (45%), Gaps = 44/396 (11%) Query: 11 LVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSL-LDVVEYGSEVRLLSELGVVMLLFLAG 69 L +A FG +L P +G + G ++ ++ + S++ E G+V L+F+ G Sbjct: 13 LWLAVGFGIFLKKLDMPVIIGYICTGTVLAAFFKINDFDLLSDI---GEFGIVFLMFMIG 69 Query: 70 LETDVEEFKHVGLSAFIVAVMGV----FVPFLLGYLVSVLHGYGSLKALFFGGVLTATSV 125 +E + ++ K + + ++ V + FLLGY V G + +L G L+ +S Sbjct: 70 IEFNFDKLKSIKQEVLVFGLLQVVLCALIAFLLGYFVL---GLSPIFSLVLGMGLSLSST 126 Query: 126 GLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLE- 184 + D K+L T +G + + I D+ I +L +L + S+ ++ +++L+ Sbjct: 127 AIVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIPMLLILTILGSKD----SNVNLLILKT 182 Query: 185 ---VAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITG 241 I +L +L G +L ++ LPE +VI+ A L+ F + G Sbjct: 183 FISAGIILVLLLLPGKKGANLILEQAKDTRLPEIFIGTILVIVCSAAGLSHFFGFSMSLG 242 Query: 242 AYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIA 301 A++ G+ +S + + ++ + +LF+ +F ++IG++ ++ F +++ LI Sbjct: 243 AFIVGMAISKSRYKINVQEEFAQL-KNLFLALFFITIGMQINVSFFMEK-FFVVIFLLIL 300 Query: 302 VVGKIIGCGFGALVARFKPIE-AIQVGIGMIPRMEVALII---------ANVGLKEGIL- 350 V+G + AL+ F+ + AI+ + + E + +I N+ K+GIL Sbjct: 301 VMGFKTAIIY-ALLRFFRDAKTAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILG 359 Query: 351 ----------TRGDL-AVPVTMVVITTLITPFLLKW 375 + D+ + + MVV + L TPF+LK+ Sbjct: 360 FLHQKNILNIAQNDIHQLLILMVVFSMLATPFILKY 395 >pir||T35370 probable transmembrane transport protein - Streptomyces coelicolor >gi|5123877|emb|CAB45469.1| (AL079348) putative transmembrane transport protein [Streptomyces coelicolor A3(2)] Length = 403 Score = 92.8 bits (227), Expect = 6e-18 Identities = 82/366 (22%), Positives = 171/366 (46%), Gaps = 13/366 (3%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLL-SELGV 61 V +EL I++ + G ++ R+GF LL G+ G + ++ E +E+GV Sbjct: 7 VLIELGAIILALGLLGRIAGRVGFSPIPLYLLAGLAFGHGGMLPMQASEEFTATGAEIGV 66 Query: 62 VMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLT 121 ++LL L GLE E + + + + + G + +++ G+G + A+ GV Sbjct: 67 ILLLLLLGLEYSASELVTNLKTQYPSGAVDFVLNAVPGAVAALVLGWGPVAAVALAGVTW 126 Query: 122 ATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEII 181 +S G+ +L D+ +L + +L +++D+ V L +L A+ + + + ++ Sbjct: 127 ISSSGVIAKVLGDLGRLGNRETPVVLGVLVIEDLAMAVYLPILTALLAGVSLAGGAVTLL 186 Query: 182 LLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITG 241 + + +L + + H + S+ ET+ + + L+ A LA++ Q++ G Sbjct: 187 ISLGTVGAVLYLALRHGRLISRAVSSDSA---ETLLLVVLGLTLVVAGLAQELQVSAAVG 243 Query: 242 AYLAGLLVS--MTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSL 299 A+L G+ +S + EG+ ++T LF +F V G+ T+ + V AL+ + Sbjct: 244 AFLVGIALSGEVAEGA----SSLLTPLRDLFAAVFFVFFGLSTNPADIPPVLVPALLLAA 299 Query: 300 IAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTR-GDLAVP 358 + + K+ + A A + + G ++ R E +++IA GL G+ R G LA Sbjct: 300 VTALTKVATGWYAAHRAGLRGAGRWRAGGTLVARGEFSIVIA--GLAVGVEPRIGPLATA 357 Query: 359 VTMVVI 364 ++++ Sbjct: 358 YVLILV 363 >pir||C71934 glutathione-regulated potassium-efflux system protein - Helicobacter pylori (strain J99) >gi|4154959|gb|AAD06004.1| (AE001476) GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYSTEM PROTEIN [Helicobacter pylori J99] Length = 416 Score = 92.4 bits (226), Expect = 8e-18 Identities = 90/391 (23%), Positives = 175/391 (44%), Gaps = 34/391 (8%) Query: 11 LVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLAGL 70 L +A FG +L P +G + G ++ + + ++ + + E G+V L+F+ G+ Sbjct: 13 LWLAVGFGIFLKKLDMPVIIGYICTGTVLA-AFFKINDFNL-LSDIGEFGIVFLMFMIGI 70 Query: 71 ETDVEEFKHVGLSAFIVAVMGV----FVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVG 126 E + ++ K + + ++ V + FLLGY V G + +L G L+ +S Sbjct: 71 EFNFDKLKSIKQEVLVFGLLQVVLCALIAFLLGYFVL---GLSPIFSLVLGMGLSLSSTA 127 Query: 127 LTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVA 186 + D K+L T +G + + I D+ I +L +L + S+ I L+ Sbjct: 128 IVLKFFEDSKQLSTPMGKSAVGILIFQDIAAIPMLLILTILGSKDSHVNLLILKTLISAG 187 Query: 187 IFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAG 246 I IL +L G +L ++ LPE +VI+ A L+ F + GA++ G Sbjct: 188 IILILLLLPGKKGANLILEQAKDTRLPEIFIGTVLVIVCSAAGLSHFFGFSMSLGAFIVG 247 Query: 247 LLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVVGKI 306 + +S + + ++ + +LF+ +F ++IG++ ++ F +V L+ +V Sbjct: 248 MAISKSRYKINVQEEFAQL-KNLFLALFFITIGMQINVSFFMEK--FFVVIFLLILVMSF 304 Query: 307 IGCGFGALVARFKPIE-AIQVGIGMIPRMEVALII---------ANVGLKEGIL------ 350 AL+ F+ + AI+ + + E + +I N+ K+GIL Sbjct: 305 KTFIIYALLRFFRDAKTAIKTALSLAQIGEFSFVIFLNSGSHQLFNLQEKKGILGFLHQK 364 Query: 351 -----TRGDL-AVPVTMVVITTLITPFLLKW 375 + D+ + + MVV + L TPF+LK+ Sbjct: 365 NILNIAQNDIHQLLILMVVFSMLATPFILKY 395 >pir||F82595 glutathione-regulated potassium efflux system protein XF2140 [imported] - Xylella fastidiosa (strain 9a5c) >gi|9107273|gb|AAF84939.1|AE004028_7 (AE004028) cation:proton antiporter [Xylella fastidiosa] Length = 572 Score = 92.4 bits (226), Expect = 8e-18 Identities = 87/387 (22%), Positives = 168/387 (42%), Gaps = 19/387 (4%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLF 66 +A+ L +A + G L+ RL +G L+ G+ +GP V LSELGV++L+F Sbjct: 11 IAVGLSLAFVLGALAQRLKLSPLVGYLVAGICVGPFTPGFVADQQIANQLSELGVMLLMF 70 Query: 67 LAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVG 126 GL +E+ V A A++ + LLG+ ++ G+ ++ + FG L+ S Sbjct: 71 GVGLHFSLEDLLEVKAIAIPGALVQIAAATLLGWGLAWTMGWPMVQGVVFGLALSVASTV 130 Query: 127 LTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAM-----------------SS 169 + L + + + T+ G + IV+D++ ++ L LL A+ SS Sbjct: 131 VLLRALEERRLIDTQRGRIAVGWLIVEDLVMVLALVLLPALAQMLNGNESVAAHTPNGSS 190 Query: 170 RGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAY 229 G + + LL++A F + +++G ++ L E T + I L A+ Sbjct: 191 DGNAMLTALGWTLLKMAGFVAVMLVVGRRVIPWSLEKVAATGSRELFTLAVLGIALGVAF 250 Query: 230 -LAEKFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLT 288 A+ F ++ GA+ AG+++ +E S + + F +F V++G+ + +L Sbjct: 251 GSAKLFGVSFALGAFFAGMVLKGSETSHAAATDSLPL-RDAFAVLFFVAVGMLFNPAILI 309 Query: 289 HAGVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEG 348 + L L +GK A+ + + E + I+A +G++ Sbjct: 310 EHPLQVLATFLTITIGKSAAAFLIVRAFGHPTSTALTISTSLAQIGEFSFILAGLGIQLA 369 Query: 349 ILTRGDLAVPVTMVVITTLITPFLLKW 375 IL + + +++ + PFL W Sbjct: 370 ILPETGRDLILAGALLSIIANPFLFTW 396 >pir||A72473 probable Na+/H+ antiporter APE2426 - Aeropyrum pernix (strain K1) >gi|5106130|dbj|BAA81441.1| (AP000064) 412aa long hypothetical Na+/H+ antiporter [Aeropyrum pernix] Length = 412 Score = 92.1 bits (225), Expect = 1e-17 Identities = 86/380 (22%), Positives = 175/380 (45%), Gaps = 25/380 (6%) Query: 1 MEVFLELAIILVIAKIFGYLSVR-----LGFPAALGQLLGGVIIGPSLLDVVEYGSEVRL 55 +E +E I++++ F L+ +G P + +++ G ++ V+ + L Sbjct: 50 LEFEVEYDILVIVLVAFYILAATRIAHVIGLPPGVVEIIMGAMLA---FWGVKSTEVLTL 106 Query: 56 LSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALF 115 L+ +G +LLF+AG E D+ + + A IVA++ P L L+ V G +L Sbjct: 107 LAAIGANLLLFMAGSEIDLALLRSILPQAVIVALVSALAPLALTALLHVYLGLSLTSSLV 166 Query: 116 FGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEV 175 L+ATSV LT +L + +R+++G LA+A++ D+ G+++L + A S Sbjct: 167 ILASLSATSVALTYLLLSSYRLVRSRLGQLALASAMLLDLSGMIMLNIATASISPSLAFY 226 Query: 176 EDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQ 235 I I+L + ++ +L L G P E+ ++ + ++I +L++ Sbjct: 227 --IVILLAALLLYPLLPRLGGAPFEAEIRLIT--------------MTVIILGFLSDFVG 270 Query: 236 LAGITGAYLAGLLVSMTEGSR-KITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFA 294 + + +++ G++ S T +R ++ +K+ ++ F P F ++ G+ D + H A Sbjct: 271 VHSVLTSFILGVIASETVRTRVQLREKLESLATGFFTPFFFIASGMSIDPGIPLHYVALA 330 Query: 295 LVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGD 354 L + + + F + ++ + V +I A+VG + G+L Sbjct: 331 LAGGVALALARTYTVYFYFRLTGSSRRSSLIAASSTAMLLTVTIIAASVGFQLGLLDSLM 390 Query: 355 LAVPVTMVVITTLITPFLLK 374 +V V +VV T L + L+K Sbjct: 391 YSVLVWIVVGTILGSFALVK 410 >sp|P45522|KEFB_ECOLI GLUTATHIONE-REGULATED POTASSIUM-EFFLUX SYSTEM PROTEIN KEFB (K(+)/H(+) ANTIPORTER) (NEM-ACTIVATABLE K+/H+ ANTIPORTER) >gi|7444645|pir||A65129 glutathione-regulated potassium-efflux system protein kefB - Escherichia coli (strain K-12) >gi|606284|gb|AAA58147.1| (U18997) ORF_f601 [Escherichia coli] >gi|1789749|gb|AAC76375.1| (AE000411) K+ efflux; NEM-activable K+/H+ antiporter [Escherichia coli K12] Length = 601 Score = 90.1 bits (220), Expect = 4e-17 Identities = 83/373 (22%), Positives = 168/373 (44%), Gaps = 6/373 (1%) Query: 4 FLELAIILVIAKIFGY-LSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVV 62 FL ++ + A + L+ RLG A LG LL G+ IGP L + E+ SELGVV Sbjct: 6 FLLAGVLFLFAAVAAVPLASRLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVV 65 Query: 63 MLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTA 122 L+F+ GLE + + + S F V V + L + +L + A+ G L Sbjct: 66 FLMFIIGLELNPSKLWQLRRSIFGVGAAQVLLSAALLAGLLMLTDFAWQAAVVGGIGLAM 125 Query: 123 TSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIIL 182 +S + ++ + R++ G + + D+ I L L+ ++ E + + Sbjct: 126 SSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVIPALALVPLLAGSAD---EHFDWMK 182 Query: 183 LEVAIFFILGILI-GHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITG 241 + + + +G+LI G L++ V + E T ++++L A + L+ G Sbjct: 183 VGMKVLAFVGMLIGGRYLLRPVFRFIAASGVREVFTAATLLLVLGSALFMDALGLSMALG 242 Query: 242 AYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIA 301 ++AG+L++ +E ++ I L + +F +S+G+ ++ VL ++ ++ ++ Sbjct: 243 TFIAGVLLAESEYRHELETAIDPF-KGLLLGLFFISVGMSLNLGVLYTHLLWVVISVVVL 301 Query: 302 VVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTM 361 V KI+ A + + E +Q + E A ++ + + + +A+ + Sbjct: 302 VAVKILVLYLLARLYGVRSSERMQFAGVLSQGGEFAFVLFSTASSQRLFQGDQMALLLVT 361 Query: 362 VVITTLITPFLLK 374 V ++ + TP L+K Sbjct: 362 VTLSMMTTPLLMK 374 >pir||C81997 probable glutathione-regulated potassium-efflux system protein NMA0060 [imported] - Neisseria meningitidis (group A strain Z2491) >gi|7378833|emb|CAB83376.1| (AL162752) putative transmembrane transport protein [Neisseria meningitidis Z2491] Length = 658 Score = 90.1 bits (220), Expect = 4e-17 Identities = 78/369 (21%), Positives = 164/369 (44%), Gaps = 4/369 (1%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLF 66 + I+L+++ I L + P+ LG LL G + GP +L ++ L E+G+V L+F Sbjct: 9 IVIVLLVSVITVILCRKFNIPSMLGYLLVGFLAGPGMLSLIPKSHATDYLGEIGIVFLMF 68 Query: 67 LAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVG 126 GLE + + + + F + + V V L + +L G A G L +S Sbjct: 69 SIGLEFSLPKLRAMRRLVFGLGGLQVGVTMLSVMGILMLTGVPFNWAFAVSGALAMSSTA 128 Query: 127 LTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVA 186 + + IL + +L G + ++ D+ + ++ L+ A++ G + + L Sbjct: 129 IVSRILSEKTELGQPHGQMAMGVLLMQDIAVVPLMILIPALAGGGDGNIW-AALGLAFAK 187 Query: 187 IFFILGIL--IGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYL 244 + LG+L +G ++ + + E +++ L AYL E L+ GA++ Sbjct: 188 MLLTLGLLFFVGSKIMSRWFRMVAKRKSSELFMINVLLVTLGVAYLTELEGLSMALGAFV 247 Query: 245 AGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVVG 304 AG+L+S TE ++ D I + + F +++G++ DI+ L L+ + +V Sbjct: 248 AGMLLSETEYRFQVEDDIRPF-RDILLGFFFITVGMKLDIQALIGGWRQVLMLLAMLLVL 306 Query: 305 KIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVVI 364 K + A + ++++ + + E ++ + + +++ V++ Sbjct: 307 KALVVFAIAFKMKHSVGDSLKTALYLAQGGEFGFVMLAIAGQLDMVSLEWEQAATAAVLL 366 Query: 365 TTLITPFLL 373 + +I PFLL Sbjct: 367 SMIIAPFLL 375 >pir||B81225 glutathione-regulated potassium-efflux system protein NMB0209 [imported] - Neisseria meningitidis (group B strain MD58) >gi|7225431|gb|AAF40666.1| (AE002378) glutathione-regulated potassium-efflux system protein [Neisseria meningitidis MC58] Length = 658 Score = 89.7 bits (219), Expect = 5e-17 Identities = 77/369 (20%), Positives = 164/369 (43%), Gaps = 4/369 (1%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLF 66 + I+L+++ I L + P+ LG LL G + GP +L ++ L E+G+V L+F Sbjct: 9 IVIVLLVSVITVILCRKFNIPSMLGYLLVGFLAGPGMLSLIPKSHATDYLGEIGIVFLMF 68 Query: 67 LAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVG 126 GLE + + + + F + + V + L + +L G A G L +S Sbjct: 69 SIGLEFSLPKLRAMRRLVFGLGGLQVGITMLSVMGILMLTGVPFNWAFAVSGALAMSSTA 128 Query: 127 LTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVA 186 + + IL + +L G + ++ D+ + ++ L+ A++ G + + L Sbjct: 129 IVSRILSEKTELGQPHGQMAMGVLLMQDIAVVPLMILIPALAGGGDGNIW-AALGLAFAK 187 Query: 187 IFFILGIL--IGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYL 244 + LG+L +G ++ + + E +++ L AYL E L+ GA++ Sbjct: 188 MLLTLGLLFFVGSKIMSRWFRMVAKRKSSELFMINVLLVTLGVAYLTELEGLSMALGAFV 247 Query: 245 AGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVVG 304 AG+L+S TE ++ D I + + F +++G++ DI+ L L+ + +V Sbjct: 248 AGMLLSETEYRFQVEDDIRPF-RDILLGFFFITVGMKLDIQALIGGWRQVLMLLAMLLVL 306 Query: 305 KIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVVI 364 K + A + ++++ + + E ++ + + +++ V++ Sbjct: 307 KALVVFAIAFKMKHSVGDSLKTALYLAQGGEFGFVMLAIAGQLDMVSPEWEQAATAAVLL 366 Query: 365 TTLITPFLL 373 + +I PFLL Sbjct: 367 SMIIAPFLL 375 >pir||T36239 probable integral membrane efflux protein - Streptomyces coelicolor >gi|4582390|emb|CAB40337.1| (AL049573) putative integral membrane efflux protein [Streptomyces coelicolor A3(2)] Length = 404 Score = 88.5 bits (216), Expect = 1e-16 Identities = 89/367 (24%), Positives = 164/367 (44%), Gaps = 30/367 (8%) Query: 23 RLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLAGLETDVEEFKHVGL 82 R+ P + ++ G+++GP +L V L++LG+ ML+FLAG E D F V Sbjct: 27 RVRVPLVIFEISLGIVMGPDVLGWARPDDVVDTLADLGLSMLIFLAGYEID---FAAVRG 83 Query: 83 SAFIVAVMGVFVPFLLGYLVSVLHGYGSL-KALFFGGVLTATSVGLTTSILMDMKKLRTK 141 ++ V + G +++L G + +A G LT+T++G +L D +LR + Sbjct: 84 DTLRRSLWSWPVALVAGIALALLVSGGDVFEAFVIGTALTSTTLGTVLPMLRDSGELRGR 143 Query: 142 VGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEII-----LLEVAIFFILGILIG 196 GT I A V + ++ + LL++ G+ E ++ + A+F+ L Sbjct: 144 FGTVISAFGAVGEFGPVIAVALLLS----GRRPAESAALLAAFGAITTAAVFWAL----- 194 Query: 197 HPLVKEVLTLSERI--TLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLLVSMT-- 252 P L+ER T + F ++++ LAE F L + GA+ AG+L + Sbjct: 195 RPRPPWFARLTERTLHTSGQFAVRFVMLLLACMLGLAEVFGLDVLLGAFAAGVLTRLVLL 254 Query: 253 ----EGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTH-AGVFALVYSLIAVVGKII 307 S ++ K+ +G+ +P+F V GIE D+ L H G LV + + + Sbjct: 255 RAAPASSGEVLGKVEAMGFGFLVPLFYVVTGIEFDLAALLHDPGALLLVPGFLLLFLLVH 314 Query: 308 GCGFGALVARFKPIEAIQVGIGMIPRMEVALIIA--NVGLKEGILTRGDLAVPVTMVVIT 365 G G L+A + + + + L++A +G+ + ++ A V +++ Sbjct: 315 G-GPVYLLAPRDLGRGDRAALALFTSTCLPLVVAITTIGVDQELIATDRAASLVGAAMVS 373 Query: 366 TLITPFL 372 L+ P L Sbjct: 374 VLVFPLL 380 >gb|AAA84962.1| (U37008) KefC [Myxococcus xanthus] Length = 598 Score = 87.8 bits (214), Expect = 2e-16 Identities = 89/373 (23%), Positives = 169/373 (44%), Gaps = 16/373 (4%) Query: 4 FLELAIILVIAKIFGY-LSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVV 62 FL+ A++ + A + LS RLG + LG L GG +IGP L ++ + ++ELGVV Sbjct: 3 FLQQALVFLAAVVLADPLSRRLGLGSVLGYLAGGAVIGPWGLKLISDVEHIFHVAELGVV 62 Query: 63 MLLFLAGLETDVEEFKHVGLSAF-IVAVMGVFVPFLL---GYLVSVLHGYGSLKALFFGG 118 +LL LE + S F + +F LL G L S+ G A+ G Sbjct: 63 VLLLFVSLELQTSRLWALRRSVFGLGGAQVLFTGALLASVGLLCSLTWG----AAIVTGF 118 Query: 119 VLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDI 178 L+ +S +L++ +L T G + D+ + +L LL + G + Sbjct: 119 GLSLSSTAFALQLLVERNRLTTPYGQLAFGILLFQDLAVVPLLALLPLLGDGGAPSPGTV 178 Query: 179 EIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAG 238 ++LL+ + +L G LV+ E T A+++++ A + L+ Sbjct: 179 WLLLLKDVGVLLAEVLSGRYLVRPAFRAVAATHRQELFTATALLLVVATASVINAVGLSM 238 Query: 239 ITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAG--VFALV 296 A LAG+L++ +E ++ + L + +F +S+G+ ++ ++ VF LV Sbjct: 239 GLAASLAGVLLADSEYRHELEADLAPF-KGLLMGLFFISVGMTVNLSLILQKPLLVFGLV 297 Query: 297 YSLIAVVGKII-GCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDL 355 L+A+ G ++ G G AL R +P A+ + + + E A ++ ++ + ++ R Sbjct: 298 LGLVALKGAVLYGLGRMAL-GRREP--ALDLAVVISQGGEFAFVLFSLATAQHVMERSLS 354 Query: 356 AVPVTMVVITTLI 368 + V +V ++ + Sbjct: 355 ELLVVVVGLSMAV 367 >pir||T01227 glutathione-regulated potassium-efflux system protein kefB homolog F6N23.15 - Arabidopsis thaliana >gi|3047127|gb|AAC13638.1| (AF058919) F6N23.15 gene product [Arabidopsis thaliana] >gi|7267402|emb|CAB80872.1| (AL161472) putative potassium/H+ antiporter [Arabidopsis thaliana] Length = 617 Score = 87.0 bits (212), Expect = 3e-16 Identities = 94/374 (25%), Positives = 167/374 (44%), Gaps = 39/374 (10%) Query: 30 LGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAV 89 LG L G++IGP L ++ + ++E GVV LLF GLE VE + F + Sbjct: 49 LGYLAAGILIGPYGLSIIRNVHGTKAIAEFGVVFLLFNIGLELSVERLSSMKKYVFGLGS 108 Query: 90 MGVFV-PFLLGYLVSVLHGYGSLKALFFGGVLTATSVGLTTSILMDMKKLRTKVGTTILA 148 V V ++G + + G A+ G L +S + +L + + ++ G + Sbjct: 109 AQVLVTAAVIGLITHYVAGQAGPAAIVIGNGLALSSTAVVLQVLQERGESTSRHGRATFS 168 Query: 149 AAIVDDVLGIVILTLLVAM----SSRGKV------EVEDIEIILLEVAIFFIL--GILIG 196 + D L +V+L +L+ + SS+G + E + I VAI I+ G L+ Sbjct: 169 VLLFQD-LAVVVLLILIPLISPNSSKGGIGFQAIAEALGLAAIKAAVAITGIIAGGRLLL 227 Query: 197 HPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLLVSMTEGSR 256 P+ K++ E + ++++L + L + L+ GA+LAGLL++ TE S Sbjct: 228 RPIYKQIAENRN----AEIFSANTLLVILGTSLLTARAGLSMALGAFLAGLLLAETEFSL 283 Query: 257 KITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIA--VVGK-----IIGC 309 ++ I L + +F +++G+ D ++L F L+ + +VGK IIG Sbjct: 284 QVESDIAPY-RGLLLGLFFMTVGMSIDPKLL--LANFPLIMGTLGLLLVGKTILVVIIGK 340 Query: 310 GFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVVITTLIT 369 FG + I A++VG+ + P E A + + + I+ + + V L+T Sbjct: 341 LFGISI-----ISAVRVGLLLAPGGEFAFVAFGEAVNQVIIY---MMISVFCFFTMGLVT 392 Query: 370 PFL---LKWAFSKG 380 L W F +G Sbjct: 393 AVFLGELDWYFFQG 406 >gb|AAD10158.1| (AC005917) putative potassium/proton antiporter [Arabidopsis thaliana] Length = 574 Score = 87.0 bits (212), Expect = 3e-16 Identities = 82/382 (21%), Positives = 164/382 (42%), Gaps = 16/382 (4%) Query: 1 MEVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELG 60 + + +L +++V A G G P G LL G IIGP L V +V +++ G Sbjct: 152 LRLISDLVVVIVSATCGGIAFACAGQPVITGYLLAGSIIGPGGLSFVSEMVQVETVAQFG 211 Query: 61 VVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVL 120 V+ LLF GLE + + V A ++ +F+ L + + L G + +F G L Sbjct: 212 VIFLLFALGLEFSAAKLRVVRAVAIPGGLLQIFLFMCLSGITASLCGGKLTEGIFVGAFL 271 Query: 121 TATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVE-----V 175 + +S + LM+ + + L I D +G++ L V + G ++ Sbjct: 272 SMSSTAVVLKFLMERNSI------SALHGQITDCAVGLLFALLPVLGGTSGVLQGVLSMA 325 Query: 176 EDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQ 235 + + I++ + F+L +K + +LS + E A+ L+ A+ ++K Sbjct: 326 KSLAILIAFLGALFVLSRTWVPWFLKLMTSLSSQTN--ELYQLAAVAFCLLVAWCSDKLG 383 Query: 236 LAGITGAYLAGLLVSMTEGSRKITDKIMTIG---YSLFIPIFLVSIGIETDIRVLTHAGV 292 L+ G++ AG+++S T+ ++ ++ + + F +FL SIG+ + L + Sbjct: 384 LSLELGSFAAGVMISTTDLAQHTLEQARSQVEPIRNFFAALFLASIGMLIHMHFLWNHVD 443 Query: 293 FALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTR 352 L L+ +V K + V + A+ VG+ + E A ++ + ++ Sbjct: 444 ILLAAVLLVIVIKTVVVAIVVKVFGYNNKTAVLVGMSLAQIGEFAFVLLSRASNLHLIES 503 Query: 353 GDLAVPVTMVVITTLITPFLLK 374 + + ++ + TP L K Sbjct: 504 KLYLLLLGTTALSLVTTPLLFK 525 >gb|AAD32281.1|AC006533_5 (AC006533) putative Na+/H+ antiporter [Arabidopsis thaliana] Length = 735 Score = 87.0 bits (212), Expect = 3e-16 Identities = 76/298 (25%), Positives = 137/298 (45%), Gaps = 11/298 (3%) Query: 57 SELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFF 116 + L +V +FL GL D+ K + I+A++G+ L G + L G + Sbjct: 7 ANLALVYNVFLLGLGLDLRMIKIKDIKPVIIAIVGLLAALLAGAGLYYLPSNGEADKILA 66 Query: 117 GGVLTATSVGLTT-----SILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRG 171 G + + + G T IL D+K LRT +G T + AA+V D+ ++ +A+ S+ Sbjct: 67 GCMYWSIAFGCTNFPDLARILADLKLLRTDMGHTAMCAAVVTDLCTWILFIFGMAIFSKS 126 Query: 172 KVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLS-ERITLPETVTTFAIVIMLIFAYL 230 V E + L F +L + P V + + E + +T + + ++I + + Sbjct: 127 GVRNEMLPYSLASTIAFVLLCYFVIQPGVAWIFNNTVEGGQVGDTHVWYTLAGVIICSLI 186 Query: 231 AEKFQLAGITGAYLAGLLVSMTEGSRK-ITDKIMTIGYSLFIPIFLVSIGIETDIRVLTH 289 E + ITGA+L GL + RK I +K+ + +P+F + G+ DI + Sbjct: 187 TEVCGVHSITGAFLFGLSIPHDHIIRKMIEEKLHDFLSGMLMPLFYIICGLRADIGYMNR 246 Query: 290 ---AGVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVG 344 G+ A+V S +V+ KI+ F ++ R + + +G M + +AL+I N G Sbjct: 247 TVSVGMMAVVTS-ASVMVKILSTMFCSIFLRIPLRDGLAIGALMNTKGTMALVILNAG 303 >pir||F69201 conserved hypothetical protein MTH760 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2621849|gb|AAB85263.1| (AE000854) Na+/H+-exchanging protein:Na+/H+ antiporter [Methanobacterium thermoautotrophicum] Length = 399 Score = 85.4 bits (208), Expect = 1e-15 Identities = 85/391 (21%), Positives = 176/391 (44%), Gaps = 25/391 (6%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLD-----VVEYGSEVRLLS 57 V +A+I+++ +F + R P LG L+ G++IGP L+ +++ ++R+++ Sbjct: 4 VAFSVAVIILLGLLFNRVFTRARLPGILGMLILGILIGPHGLNLISKSIMDISPDLRVIA 63 Query: 58 ELGVVMLLFLAGLETDVEEFKHVGLSAFIVA-VMGVFVPFLLGYLVSVLHGYGSLKALFF 116 ++++L AG ++E + VG++A ++ + VF + + G ++A Sbjct: 64 ---LIIILLRAGFGINLESLRKVGMTAVKMSFIPDVFEGLAVMVASHYILGLPIIEAGIL 120 Query: 117 GGVLTATSVGLTTSILMDM--KKLRTKVG--TTILAAAIVDDVLGIVILTLLVAMSSRGK 172 G V+ A S + ++ +++ T G T IL A VDDV+ I + ++ + + + Sbjct: 121 GFVIAAVSPAVIVPQMLSFIERRMGTAKGIPTIILTGASVDDVVSITLFSVFLGIYQGQQ 180 Query: 173 VEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTF-----AIVIMLIF 227 V ++ + + V + + GI G L ++ L R + T T AI++ + Sbjct: 181 V---NLLVEAIGVPLSILTGITGGLALGLALVYLFRRFEIRNTEKTLIILGAAILLKNMG 237 Query: 228 AYLAEKFQLAGITGAYLAGLLV--SMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIR 285 ++ +A + G + GL++ M E K+++K + I +F V +G + D+R Sbjct: 238 DLISTYLPIAALVGVMVVGLVILERMPETGLKLSEKFNKVWIFAEILLF-VLVGAQVDVR 296 Query: 286 VLTHAGVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGL 345 ++ H G+ L ++ + IG E + IP+ V I + L Sbjct: 297 LIFHVGLLGLAVITAGLMVRSIGVLLSLKGTDLNLKEKVFCISAYIPKATVQAAIGAIPL 356 Query: 346 KEGILT-RGDLAVPVTMVVITTLITPFLLKW 375 G+ LA+ V ++ T + +KW Sbjct: 357 AAGVAAGETILAMAVLAILFTAPLGSLAVKW 387 >pir||T35102 probable transmembrane transport protein - Streptomyces coelicolor >gi|2995290|emb|CAA18319.1| (AL022268) putative transmembrane transport protein [Streptomyces coelicolor A3(2)] Length = 411 Score = 84.7 bits (206), Expect = 2e-15 Identities = 78/366 (21%), Positives = 165/366 (44%), Gaps = 11/366 (3%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPS-LLDVVEYGSEVRLLSELGV 61 + +E I++ + G + R LL G+ G LL + V +E+GV Sbjct: 6 LLIEFGSIILGLGLLGRFAGRYRLSPIPLYLLAGLAFGEGGLLPLGASEEFVATGAEIGV 65 Query: 62 VMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLT 121 ++LL + GLE + S + ++ + + G + ++L G+G + A+ GV Sbjct: 66 ILLLLMLGLEYTASDLVTNLKSHYPAGLVDCALNAVPGAVAALLMGWGPVAAVVLAGVTW 125 Query: 122 ATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEII 181 +S G+ +L D+ ++ + IL+ +++D+ V L ++ A+ + + I + Sbjct: 126 ISSSGVIAKVLGDLGRVGNRETPVILSVLVLEDLAMAVYLPIVTALVAGAGLMTGSITLA 185 Query: 182 LLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITG 241 + A +L + + + + S+ PE + + + ++ A +A++ Q++ G Sbjct: 186 VALAAAGLVLFVAVRYGRLISRFVSSDD---PEKLLLVVLGLTILVAGVAQQLQVSAAVG 242 Query: 242 AYLAGLLVS--MTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSL 299 A+L G+ +S + EG+ + + LF +F V G+ TD + + AL +L Sbjct: 243 AFLVGIALSGEVAEGAHTLLSPLR----DLFAAVFFVFFGLHTDPASIPPVLLPALALAL 298 Query: 300 IAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGI-LTRGDLAVP 358 + V KI + A A + G ++ R E +++IA + + GI + G LA Sbjct: 299 LTAVTKIATGYWAARRAGISVKGRWRAGGALVARGEFSIVIAGLAVSAGIEPSLGPLATA 358 Query: 359 VTMVVI 364 ++++ Sbjct: 359 YVLILV 364 >gb|AAD30610.1|AC007153_2 (AC007153) similar to Na/H antiporter proteins [Arabidopsis thaliana] Length = 855 Score = 84.7 bits (206), Expect = 2e-15 Identities = 88/377 (23%), Positives = 162/377 (42%), Gaps = 34/377 (9%) Query: 15 KIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEY----------GSEVRLLSELGVVML 64 ++ YL+ L P + Q+L G++ PS+L + + + L +V Sbjct: 66 RVLYYLTRPLYLPPFVAQILCGLLFSPSVLGNTRFIIAHVFPYRFTMVLETFANLALVYN 125 Query: 65 LFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATS 124 +FL GL D+ + L I+A G+ V +G + L G G + G V + + Sbjct: 126 IFLLGLGMDLRMVRITELKPVIIAFTGLLVALPVGAFLYYLPGNGHPDKIISGCVFWSVA 185 Query: 125 VGLTT-----SILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIE 179 + T IL D+K LR+ +G T + AAIV D+ V+L A S+ + + Sbjct: 186 LACTNFPDLARILADLKLLRSDMGRTAMCAAIVTDLCTWVLLVFGFASFSKSGTWNKMMP 245 Query: 180 IILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGI 239 +++ AIF +L I + P + + +TV +V+ + + + I Sbjct: 246 FVIITTAIFVLLCIFVIRPGIAWIFA--------KTVKAGGVVLC---GLITDACGVHSI 294 Query: 240 TGAYLAGLLVSMTEGSRK-ITDKIMTIGYSLFIPIFLVSIGIETDIR-VLTHAGVFALVY 297 TGA+L GL + R I +K+ + +P+F + G+ DI +L F +V Sbjct: 295 TGAFLFGLSIPHDHIIRNMIEEKLHDFLSGILMPLFYIICGLRADIGFMLQFTDKFMMVV 354 Query: 298 SLI-AVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVG-----LKEGILT 351 + + + KI+ +L +A +G M + ++L++ N G L + T Sbjct: 355 VICSSFLVKIVTTVITSLFMHIPMRDAFAIGALMNTKGTLSLVVLNAGRDTKALDSPMYT 414 Query: 352 RGDLAVPVTMVVITTLI 368 +A+ V +V+ L+ Sbjct: 415 HMTIALLVMSLVVEPLL 431 >pir||F70591 probable kefB protein - Mycobacterium tuberculosis (strain H37RV) >gi|2072703|emb|CAB08337.1| (Z95121) kefB [Mycobacterium tuberculosis] Length = 385 Score = 83.9 bits (204), Expect = 3e-15 Identities = 93/386 (24%), Positives = 162/386 (41%), Gaps = 33/386 (8%) Query: 3 VFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPS-LLDVVEYGSEVRLLSELGV 61 + EL ++L + + G ++ R LL G+ +G +L V G + + +GV Sbjct: 7 LLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGNGGILGVAAAGEFIATGAPIGV 66 Query: 62 VMLLFLAGLETDVEEF----KHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFG 117 V+LL GLE EF +H SA + V+ + G+L+ G + L Sbjct: 67 VLLLLALGLEFSATEFASSLRHHLPSAGVDIVLNATPGAVAGWLL----GLDGVAILGLA 122 Query: 118 GVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGK-VEVE 176 GV +S G+ +L D+++L + +L+ +++D L L +++ G +E Sbjct: 123 GVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLPLFAVLATDGSWLEA- 181 Query: 177 DIEIILLEVAIFFILGILI-----GHPLVKEVLTLSERITLP--ETVTTFAIVIMLIFAY 229 ++ + VAI +LG GH + +T P E + + I LI A Sbjct: 182 ---VVGMTVAIAALLGAFAASYRWGH-------HVGRLVTHPDSEQLLLRVLGITLIVAA 231 Query: 230 LAEKFQLAGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTH 289 +AE + GA+L GL ++ R ++T LF IF + IG+ D L Sbjct: 232 VAESLHASAAVGAFLVGLTLTGETADR--ARMVLTPLRDLFATIFFLGIGLSVDPGKLVS 289 Query: 290 AGVFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGI 349 AL + + K+ F A ++ G ++ R E +LII +GL G Sbjct: 290 MLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLII--IGL-AGA 346 Query: 350 LTRGDLAVPVTMVVITTLITPFLLKW 375 G A+ V + ++ P L ++ Sbjct: 347 SIPGVAALATAYVFVMAIVGPILARY 372 >emb|CAB44437.1| (AJ242913) glutathione-gated K efflux system [Klebsiella aerogenes] Length = 621 Score = 81.5 bits (198), Expect = 1e-14 Identities = 68/277 (24%), Positives = 124/277 (44%), Gaps = 9/277 (3%) Query: 8 AIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFL 67 A+I+ IA + G SV LG L+ G IIGP L +V + +E+GVV++L Sbjct: 17 ALIVPIASVLGLGSV-------LGYLIAGCIIGPWALRLVNDAEAILHFAEIGVVLMLVA 69 Query: 68 AGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVGL 127 GLE D + + S F + + +L L +L G A G L +S + Sbjct: 70 MGLELDPQRLWKLRASVFDGGALQMVACGVLIGLFCMLLGLRWQVAELIGMTLALSSTAI 129 Query: 128 TTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLL-VAMSSRGKVEVEDIEIILLEVA 186 + + +++G + A + D+ I ++ ++ + +S G + + L+VA Sbjct: 130 AMQAMNERNLTVSQMGRSAFAVLLFQDIAAIPLVAMIPLLAASGGATSLMAFALSALKVA 189 Query: 187 IFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYLAG 246 L +++G L + +L R L E + A L E+ L+ GA+LAG Sbjct: 190 AALALVVVLGRYLTRPLLRFVARSGLREVFSAVACSWSSALGLLLEEVGLSMAMGAFLAG 249 Query: 247 LLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETD 283 +L++ +E + + I + L + +F + +G+ D Sbjct: 250 VLLASSEYRHALENDIEPV-KGLLLGLFFIGVGMSID 285 >emb|CAB76285.1| (AL158057) putative transmembrane transport protein. [Streptomyces coelicolor A3(2)] Length = 446 Score = 81.5 bits (198), Expect = 1e-14 Identities = 85/354 (24%), Positives = 154/354 (43%), Gaps = 13/354 (3%) Query: 2 EVFLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSL--LDVVEYGSEVRLLSEL 59 + L + V A L R+G P +L G+++GP +VE + +LS L Sbjct: 5 DTLLAMGGAFVAAAFLARLGGRIGLPTIPLFMLAGILLGPHTPGFVLVEDAHDFEMLSAL 64 Query: 60 GVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGV 119 G+V+LLF GLE +++ + G + + + G + G+G +AL GV Sbjct: 65 GLVLLLFYLGLEFHLDDLRSGGKRLLTAGGIYLLLNVGAGLGFGFVLGWGVREALVLAGV 124 Query: 120 LTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIE 179 L +S + T IL+D+ ++ IL +V+D+ + L L + S G V D Sbjct: 125 LGISSSAIVTKILIDLGRIGRPETRLILGVIVVEDIFLALYLAALQPVIS-GAHGVADTA 183 Query: 180 IILLEVAIFFIL---GILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQL 236 + + F ++ G LV ++ + L + A+++ A ++E + Sbjct: 184 LQAGKAFGFLLVLAAAARYGTRLVGRLIHTRDNELLVISFLGAAVLV----AGVSEVLGV 239 Query: 237 AGITGAYLAGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTH-AGVFAL 295 A GA++ GL+++ T +I + + + F IF + G+ D L AG A Sbjct: 240 ADAIGAFMVGLILAGTPSGPRIRELVHPL-RDAFAAIFFFAFGLAIDPGDLASVAGPVAA 298 Query: 296 VYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGI 349 +L V+ + G A V + A ++ ++ R E ALI+A + G+ Sbjct: 299 AAALTVVMNIVAGLCV-ARVYHYGSEPAAEIATTLVARGEFALILAAMAAGAGL 351 >emb|CAC12310.1| (AL445066) Na+/H+ antiporter related protein [Thermoplasma acidophilum] Length = 381 Score = 81.1 bits (197), Expect = 2e-14 Identities = 77/369 (20%), Positives = 160/369 (42%), Gaps = 20/369 (5%) Query: 16 IFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLFLAGLETDVE 75 + G L R P + ++ G+I+G +L ++ + + + + ++ G+E + E Sbjct: 2 LLGVLLDRFRIPEVVAYIVSGIIVGAGVLRIIMPSQTISDIESISLFFIILSIGVEANTE 61 Query: 76 EFKHVGLSAFIVAVMGVFVPFLLGYLV-SVLHGYGSLKALFFGGVLTATSVGLTTSILMD 134 + + + G P +LG V + + +G + + ++ S+ + + +LM Sbjct: 62 YIYGNLKRSILFTISGFIFPMILGLAVLNFISPFGFIPSFVVSLSVSVPSISIISVLLMK 121 Query: 135 MKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLEVAIFFILGIL 194 L+ G IL++ ++ D++ ++L+ A + +E + ++L + I I+ Sbjct: 122 YDLLKVNGGRLILSSVVLTDIVAFIMLS---ATTENVYHVLESLGFVILFFVVIAIFDII 178 Query: 195 IGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEK--FQLAGIT---GAYLAGLLV 249 I + + + +R +T + + M+I A L F++ GIT G++ AG+L+ Sbjct: 179 IRRRAIGIMAWIEKREE--KTNMEYILFSMIIIAGLLVSIIFEVIGITYVLGSFFAGILI 236 Query: 250 SMTEGSRK----ITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVVGK 305 K + + + I S FIP+F GI L +F +I V G Sbjct: 237 HEASVGEKYHRILVNTLKRINDSFFIPLFFSIAGISVVFPHLDTFIIFLPALIVIIVSGT 296 Query: 306 IIGCGFGALVAR-FKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVT-MVV 363 ++ R P+ + V G R V +IIA + GI+T ++ + V+ Sbjct: 297 LLNYALSKRFIRSITPLTTMSVLGG---RGAVGVIIAAIAYDTGIITSIQYSLAILGTVL 353 Query: 364 ITTLITPFL 372 I+ +ITP + Sbjct: 354 ISLIITPLI 362 >dbj|BAB10612.1| (AB005243) Na+/H+ antiporter-like protein [Arabidopsis thaliana] Length = 800 Score = 80.4 bits (195), Expect = 3e-14 Identities = 93/415 (22%), Positives = 179/415 (42%), Gaps = 60/415 (14%) Query: 5 LELAIILV-IAKIFGYLSVR-LGFPAALGQLLGGVIIGPSLLDVVEYGSE---------- 52 LEL IIL+ + + ++ +R +G P + +L G+I+GP LLD++EY S+ Sbjct: 52 LELQIILIFVCIVLSHMFLRRIGIPRFVSNILAGLILGPQLLDLLEYSSDRLSLDIPGNV 111 Query: 53 -VRLLSELGVVMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGY------LVSVL 105 + ++ LG+VM FL G++T+ +G ++AV FV + G L V Sbjct: 112 ALEGVARLGLVMFTFLMGVKTNKRAVYQIGKRPIVIAVSSFFVTMISGLAFRNFRLDKVD 171 Query: 106 HGYGSLKAL-----FFGGVLTATSVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVI 160 Y L+ + T + + T ++ ++K +++G ++ A V D LG + Sbjct: 172 PLYMPLRLAPTERSVIVSIQAVTLLPVITHLVYELKMSNSELGRIAISTAAVSDFLGFLT 231 Query: 161 LTLLVAMS-----SRGKVEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLS-ERITLPE 214 L + + S G + + +I+L + I FI P+ + ++ ++ E +P+ Sbjct: 232 LVCISYVGTYRYVSPGIANRDIVALIILVLVILFIF-----KPMAQRIVDMTPEGKPVPK 286 Query: 215 TVTTFAIVIMLIFAYLAEKFQLAGITGAYLAGLLVSMTEG---SRKITDKIMTIGYSLFI 271 I+ + + F I GA L GL ++ +G + + ++ ++F Sbjct: 287 VYLYVTILTAIAASIYLSVFNQMYILGALLVGL--AIPDGPPLGSALEARFESLVTNIFF 344 Query: 272 PIFLVSIGIETDIRVLTHAGVFALVYSLIAVVGKIIGCGFGALV---ARFKPI------- 321 PI + + ++ D V +YS + I+ G +V A F P Sbjct: 345 PISIAVMAMKAD--------VVRALYSFDDISFNILLLGLTVVVKWTASFVPCLIFCELP 396 Query: 322 --EAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMVVITTLITPFLLK 374 E++ + M + V L +V L+ L+R V + V++ I P ++K Sbjct: 397 TRESVIIATIMNYKGFVDLCFFDVALRRRNLSRATYTVMIIYVLLNAGILPTIIK 451 >gi|11498844 Na+/H+ antiporter (napA-2) [Archaeoglobus fulgidus] >gi|7483893|pir||D69405 Na+/H+ antiporter (napA-2) homolog - Archaeoglobus fulgidus >gi|2649335|gb|AAB89998.1| (AE001018) Na+/H+ antiporter (napA-2) [Archaeoglobus fulgidus] Length = 338 Score = 78.8 bits (191), Expect = 1e-13 Identities = 85/371 (22%), Positives = 159/371 (41%), Gaps = 38/371 (10%) Query: 5 LELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVML 64 +ELA+I+ A I +S L +L G+ +G + + SEV L +LG+V L Sbjct: 1 MELAVIVFAAAIAAIISRMLRITPIPAYILVGMALGKAGWHL----SEVEFLGKLGIVFL 56 Query: 65 LFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATS 124 LF GL+ K + FL ++ L G+ A + +S Sbjct: 57 LFYVGLKIPPSTIKKTWQRTLKSGTIDFLFNFLPPLVLLYLIGFDLRDAFILASAIYISS 116 Query: 125 VGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLE 184 + +L+D +KL ++ + +D++ + +L L A E + ++ L Sbjct: 117 SAINLKMLVDDRKLVFTFAEVVVLLMVFEDIVLVALLFLFSAS--------EPLTLLYLA 168 Query: 185 VAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAGITGAYL 244 + L + P ++++++ + + + TF+I + +F LAEKF+++ A L Sbjct: 169 LIALTALALYAISPQIEKLMSREDEVPY---LLTFSIPSISLF--LAEKFRISEALMAIL 223 Query: 245 AGLLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVLTHAGVFALVYSLIAVVG 304 G+ + +R DK++ +F+ +F V G D+ H +L+ +AV+G Sbjct: 224 FGVAL-----NRLRIDKMLVPFKEVFLAVFFVFFGTMVDL----HFSYLSLLLIAVAVIG 274 Query: 305 KIIGCGFGALVARF--KPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAVPVTMV 362 K+ G F +ARF +A++V + R E +I L + A + V Sbjct: 275 KLAGAYF---IARFTTSKSDAVEVFKYTLARGEFTVIFP-------ALFAPEFATTLAAV 324 Query: 363 VITTLITPFLL 373 V+ T I L+ Sbjct: 325 VLFTSIAGSLI 335 >pir||JC5342 Na+/H+ antiporter cdu2 - Clostridium difficile >gi|1770129|emb|CAA63558.1| (X92982) cdu2 [Clostridium difficile] >gi|1770130|emb|CAA63559.1| (X92982) cdu2 [Clostridium difficile] Length = 313 Score = 75.7 bits (183), Expect = 8e-13 Identities = 72/313 (23%), Positives = 149/313 (47%), Gaps = 37/313 (11%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLD-----VVEYGSEVRLLSELGV 61 LA+I ++ G + R+ P LG LL G+I+GP +L+ +++ S++R ++ + Sbjct: 5 LALIFLLGMASGGIFKRIKLPNLLGMLLTGIILGPYVLNLIDNSILDISSDLR---KIAL 61 Query: 62 VMLLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPF---LLGYLVSV--LHGYGSLKALFF 116 +++L AGL D+ + K VG AV+ F+P ++G +V L G L+A Sbjct: 62 IIILTRAGLSLDINDLKKVGRP----AVLMCFIPATFEIIGMIVLAPKLLGVSILEAAVM 117 Query: 117 GGVLTATSVGLTTSILMDMKK----LRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGK 172 G V+ A S + ++ + + + +LA +DD+ IV+ T+ ++ Sbjct: 118 GAVVGAVSPAIIVPKMLKLMEEGYGTEKSIPQMLLAGTSIDDIFVIVMFTVFTGLAQGNS 177 Query: 173 VEVEDIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAE 232 + I L++ + ILG++ G + + +++ + ++ +++ + F ++ Sbjct: 178 ISA----ISFLQIPVSIILGVIAGAVIGICLAVFFKKVHMRDSAKG-VLLLSISFLMISL 232 Query: 233 KFQLAGITGAYLAGLLVSMTEG-----SRKITDKIMTIGYS-LFIP---IFLVSIGIETD 283 + L GI +GLL M+ G ++ + ++I YS L++ + V +G D Sbjct: 233 ETALEGIVP--FSGLLAVMSIGIFLQIKYRVVARRLSIKYSKLWVGAEILLFVLVGATVD 290 Query: 284 IRVLTHAGVFALV 296 I AG+ A++ Sbjct: 291 ISYAFKAGIGAVI 303 >pir||H81265 probable transmembrane transport protein Cj1684c [imported] - Campylobacter jejuni (strain NCTC 11168) >gi|6969099|emb|CAB73670.1| (AL139079) putative transmembrane transport protein [Campylobacter jejuni] Length = 391 Score = 75.7 bits (183), Expect = 8e-13 Identities = 78/316 (24%), Positives = 148/316 (46%), Gaps = 20/316 (6%) Query: 5 LELAIILVIAKIFG-YLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVM 63 L++ I++ + +F +++ L P + +++ G II + LL+ +G Sbjct: 14 LKILIVIALCLLFSPHIAKILRLPLSATEIILGAIIAH--FGFIGKSENFALLANVGFYY 71 Query: 64 LLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTAT 123 L+F+AG+E ++ F ++ +A F FLL L S + L +L F ++ Sbjct: 72 LMFIAGMEVNLRAFFNMDKE---IAKKSFFYIFLLYALSSFIVWIFGL-SLVFVIIIPVM 127 Query: 124 SVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIIL- 182 SVGL + + D K + ++ A + + V+ IV+LT+ A G ++ + IL Sbjct: 128 SVGLLSLLFKDFGKECYWLNIAMIVATLAE-VISIVLLTIAGAFLREGTGIIDVAQSILY 186 Query: 183 ------LEVAIFFILGILIG-HPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQ 235 L + F +LG+L +P +K VL E + AI I++I A + K + Sbjct: 187 LNIFLGLCLLGFKMLGVLFWWYPQLKVVLMPWEDKNEKDIRFCMAIFILIIVAMVITKLE 246 Query: 236 LAGITGAYLAG-LLVSMTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIR-VLTHAGVF 293 + + G+++AG + + + + + K+ T G+ IPIF + IG D++ +L + V Sbjct: 247 I--VLGSFIAGSFIATFFDHKKDLEHKLSTFGHGFLIPIFFIHIGSTFDLKMILDYKIVL 304 Query: 294 ALVYSLIAVVGKIIGC 309 + +VG I C Sbjct: 305 QAFLLMFVMVGLRILC 320 >pir||H71848 probable na+/h+ antiporter - Helicobacter pylori (strain J99) >gi|4155698|gb|AAD06681.1| (AE001538) putative NA+/H+ ANTIPORTER [Helicobacter pylori J99] Length = 383 Score = 74.9 bits (181), Expect = 1e-12 Identities = 62/294 (21%), Positives = 141/294 (47%), Gaps = 21/294 (7%) Query: 4 FLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVM 63 F A+I+++ I Y+S P + ++L G + + + +E ++SE+G + Sbjct: 5 FFTFALIMLLIVIAPYVSRISRLPITVVEILFGSV--GAYVGFIEPTKGFEIMSEIGFLF 62 Query: 64 LLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTAT 123 L+FL GLE ++ FK +G+S + +F L+ Y +S + + F + Sbjct: 63 LMFLCGLEVEIYLFKKLGVS----LLKRIFAYLLILYTLSFILTFSLNLEPIFMVIFPII 118 Query: 124 SVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIIL- 182 S+G+ +++ D +K + +L ++ ++L I L ++ + S G +++I Sbjct: 119 SLGMIMTLVKDYRKEILWL-DLVLKVGVIGELLSIFGLVVVDGVYSHGL----GVDLIKD 173 Query: 183 LEVAIFFILGILIGHPLVKEVLTLSERITL---PETV-----TTFAIVIMLIFAYLAEKF 234 L + I F++ I++ + K + + L P++ F++++ + Sbjct: 174 LGILIVFLILIIVAFQIFKTLFWWFPHLKLFVMPKSSQFNQDVRFSLMLFFSLVAIVVWL 233 Query: 235 QLAGITGAYLAGLLVS-MTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVL 287 ++ + GA+LAGL+VS ++ K+ +G+ F+P+F + +G D++++ Sbjct: 234 KIEMVLGAFLAGLVVSTFFPHKSELIHKLNDVGFGFFVPLFFIHVGSTLDLKLV 287 >gb|AAK43070.1| Na(+)/H(+) antiporter, putative [Sulfolobus solfataricus] Length = 599 Score = 73.7 bits (178), Expect = 3e-12 Identities = 86/375 (22%), Positives = 164/375 (42%), Gaps = 29/375 (7%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLF 66 L+++L+ + ++ RL + LLGG +I + S +L+ L + +L F Sbjct: 7 LSLMLLFTLLLAFILTRLKVSPVIAYLLGG-LISFNYFHFDFNSSYFEILNFLALNLLAF 65 Query: 67 LAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVG 126 G D+ K + A +A+ + + L+ Y + + + L A F L S+ Sbjct: 66 EIGTSFDISRAKELFRRAMGIALTELILIVLISYFIGLYLLHLDLFASLF---LVMASID 122 Query: 127 LTTSILMDM--KKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIILLE 184 +TSIL + K+ ++A A V+D+ + ++ +A++ G V I ++LE Sbjct: 123 TSTSILYKIIGNKVDKNDRDLLVAVASVEDIEVFFLYSIAIALN--GSFNVFRISFVILE 180 Query: 185 VAIF------FILGILIGHPLVKEVLTLSERITLPETVTTFAIVIMLIFAYLAEKFQLAG 238 V I F L G + K E I + IV++ +F Y+++ Q+ Sbjct: 181 VFIASLIIYAFAKYFLTGLSIFKFTSFEDESILI-----LVPIVLVFVFEYISQVTQVPA 235 Query: 239 ITGAYLAGLLVSMTEGSRKITDKIMTI-GYSLFIPIFLVSIGIETDIRVLTHAGVFALVY 297 LAG+ S GS K+ I +SL F +S+G + +++ F L+ Sbjct: 236 TLTMILAGIAFSSISGSEKVLRYTGPIREFSLI--FFFLSVG--SYLKITAGISTFVLI- 290 Query: 298 SLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKEGILTRGDLAV 357 S I + K + V+ ++A G+ M+P E +I++ L++GI D+A+ Sbjct: 291 SFIILAIKYFSFSTASWVSGTTLVKAFTNGLYMLPLSEFGIIVSLQALQQGI----DIAI 346 Query: 358 PVTMVVITTLITPFL 372 + V+ L++ + Sbjct: 347 VYYISVVVVLVSSII 361 >sp|P52071|YPH1_METEX HYPOTHETICAL PROTEIN IN PHAC 3'REGION (ORF1) >gi|551902|gb|AAA72331.1| (L07893) [phaC] gene products [Methylobacterium extorquens] Length = 276 Score = 73.4 bits (177), Expect = 4e-12 Identities = 69/264 (26%), Positives = 125/264 (47%), Gaps = 18/264 (6%) Query: 7 LAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVMLLF 66 +A+ LV A I G L+ R+ P +G L+ G+ IGP V + L+ELGV++L+F Sbjct: 11 IALGLVCAFIGGMLAQRMRLPPLVGYLVAGIAIGPFTPGFVGDPALASQLAELGVILLMF 70 Query: 67 LAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTATSVG 126 GL + + V A A++ + V +G ++ G+G+ L FG L+ S Sbjct: 71 GVGLHFSIGDLLAVRTIALPGAIVQITVATAMGAGLAWGFGWGAGAGLVFGLALSVASTV 130 Query: 127 LTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMS-SRGKVEVE--------- 176 + L L + G + IV+D+ +V L LL A++ S G ++ Sbjct: 131 VLLRALEGQGLLDSDKGRIAVGWLIVEDLAMVVALVLLPALAPSLGGEAMQAAGHHGPPE 190 Query: 177 -----DIEIILLEVAIFFILGILIGHPLVKEVLTLSERITLPE--TVTTFAIVIMLIFAY 229 + + L +V +F + ++ G L+ +L L+ R E T+ A + + FA Sbjct: 191 HGLWVTLGLTLAKVGVFVAVMLVGGRRLIPYLLGLAARTGSRELFTLAVLASAVGIAFA- 249 Query: 230 LAEKFQLAGITGAYLAGLLVSMTE 253 +E F ++ GA+ AG++++ ++ Sbjct: 250 SSELFGVSFALGAFFAGMVLAESD 273 >pir||G64667 NA+/H+ antiporter - Helicobacter pylori (strain 26695) >gi|2314343|gb|AAD08229.1| (AE000624) NA+/H+ antiporter (napA) [Helicobacter pylori 26695] Length = 383 Score = 73.4 bits (177), Expect = 4e-12 Identities = 61/294 (20%), Positives = 141/294 (47%), Gaps = 21/294 (7%) Query: 4 FLELAIILVIAKIFGYLSVRLGFPAALGQLLGGVIIGPSLLDVVEYGSEVRLLSELGVVM 63 F A+I+++ + Y+S P + ++L G + + + +E ++SE+G + Sbjct: 5 FFTFALIMLLIVMAPYMSRISRLPITVVEILFGSV--GAYVGFIEPTKGFEIMSEIGFLF 62 Query: 64 LLFLAGLETDVEEFKHVGLSAFIVAVMGVFVPFLLGYLVSVLHGYGSLKALFFGGVLTAT 123 L+FL GLE ++ FK +G+S + +F L+ Y +S + + F + Sbjct: 63 LMFLCGLEVEIYLFKKLGVS----LLKRIFAYLLILYTLSFILTFSLNLEPIFMVIFPII 118 Query: 124 SVGLTTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVEDIEIIL- 182 S+G+ +++ D +K + +L ++ ++L I L ++ + S G +++I Sbjct: 119 SLGMIMTLVKDYRKEILWL-DLVLKVGVIGELLSIFGLVVVDGVYSHGL----GMDLIKD 173 Query: 183 LEVAIFFILGILIGHPLVKEVLTLSERITL---PETV-----TTFAIVIMLIFAYLAEKF 234 L + I F++ I++ + K + + L P++ F++++ + Sbjct: 174 LGILIVFLILIIVAFQIFKTLFWWFPHLKLFVMPKSSQFNQDVRFSLMLFFSLVAIVVWL 233 Query: 235 QLAGITGAYLAGLLVS-MTEGSRKITDKIMTIGYSLFIPIFLVSIGIETDIRVL 287 ++ + GA+LAGL+VS ++ K+ +G+ F+P+F + +G D++++ Sbjct: 234 KIEMVLGAFLAGLVVSTFFPHKSELIHKLNDVGFGFFVPLFFIHVGSTLDLKLV 287 >pir||T51790 hypothetical protein F28D10_120 - Arabidopsis thaliana >gi|9798396|emb|CAC03543.1| (AL391254) putative protein [Arabidopsis thaliana] Length = 731 Score = 73.4 bits (177), Expect = 4e-12 Identities = 81/387 (20%), Positives = 167/387 (42%), Gaps = 44/387 (11%) Query: 24 LGFPAALGQLLGGVIIGPSLLDVVEYGS-------------EVRLLSELGVVMLLFLAGL 70 +G ++ G+++GP L DV+E S +R +S G +M FL + Sbjct: 9 IGISQIASYMIAGIVLGPQLFDVLEKSSGKLSVDPALDGIAALRCISVFGTLMFTFLMTV 68 Query: 71 ETDVEEFKHVGLSAFIVAVMGVFVP-FLLGY-----------LVSVLHGYGSLKALFFGG 118 T H G ++ ++ F P F LG+ + + G A+ Sbjct: 69 RTSRRVAFHSGKLPVVIGIVSFFAPLFGLGFQNFFSDNIDPHYMPLTKALGERTAI---- 124 Query: 119 VLTATSVGL--TTSILMDMKKLRTKVGTTILAAAIVDDVLGIVILTLLVAMSSRGKVEVE 176 V+T +S+ L TT IL+++K + +++G L+A +++D+LG I +++VA + V Sbjct: 125 VITQSSILLPSTTYILLELKIINSELGRLALSACVINDILG--IFSMIVASIQATYIHVS 182 Query: 177 DIEII--LLEVAIFFILGILIGHPLVKEVLTLSERITLPETVTTFAIVI-MLIFAYLAEK 233 + V IFF++ L+ P+V+ V+ + E + A++I L A Sbjct: 183 HATAYRDTVAVIIFFLVVFLVFKPMVQWVIDRTPEDKPVEDMYIHAVIITALASAAYFVF 242 Query: 234 FQLAGITGAYLAGLLVSMTEG---SRKITDKIMTIGYSLFIPIFLVSIGIETD-IRVLTH 289 F + I G + G+++ EG + K + ++F+PI + + D R+L+ Sbjct: 243 FNMKYILGPLMIGIII--PEGPPLGSALEAKFERLTMNVFLPISITFSAMRCDGARILSQ 300 Query: 290 AG--VFALVYSLIAVVGKIIGCGFGALVARFKPIEAIQVGIGMIPRMEVALIIANVGLKE 347 F + + + +V K++ C L + E++ V + + ++ L + Sbjct: 301 FNDIFFNIFLTFLILVIKLVACLAPCLYYKLPLSESLAVSFILSYKSFADFVLYEAVLDD 360 Query: 348 GILTRGDLAVPVTMVVITTLITPFLLK 374 +++ + + ++ I P +L+ Sbjct: 361 TYISQATYSFLILYSLLNAGIVPTVLR 387 Database: ./suso.pep Posted date: Jul 6, 2001 5:57 PM Number of letters in database: 840,471 Number of sequences in database: 2977 Database: /banques/blast2/nr.pep Posted date: Dec 14, 2000 12:46 PM Number of letters in database: 188,266,275 Number of sequences in database: 595,510 Lambda K H 0.329 0.148 0.408 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 118424179 Number of Sequences: 2977 Number of extensions: 4648371 Number of successful extensions: 17212 Number of sequences better than 1.0e-10: 83 Number of HSP's better than 0.0 without gapping: 18 Number of HSP's successfully gapped in prelim test: 65 Number of HSP's that attempted gapping in prelim test: 16963 Number of HSP's gapped (non-prelim): 91 length of query: 380 length of database: 189,106,746 effective HSP length: 55 effective length of query: 325 effective length of database: 156,189,961 effective search space: 50761737325 effective search space used: 50761737325 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 40 (21.7 bits) S2: 166 (69.1 bits)