BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1250 (guaB) DE:INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC
1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD).
(485 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||E75015 IMP dehydrogenase (EC 1.1.1.205) PAB1250 - Pyrococcu... 949 0.0
sp|O58045|IMDH_PYRHO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 908 0.0
sp|P42851|IMDH_PYRFU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 901 0.0
sp|Q59011|IMDH_METJA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 598 e-170
emb|CAC11365.1| (AL445063) probable inosine-5'-monophosphate deh... 561 e-159
pir||B69056 IMP dehydrogenase (EC 1.1.1.205) - Methanobacterium ... 558 e-158
gb|AAG19418.1| (AE005036) inosine monophosphate dehydrogenase; G... 518 e-146
sp|O67820|IMDH_AQUAE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 511 e-144
pir||C72264 IMP dehydrogenase (EC 1.1.1.205) - Thermotoga mariti... 509 e-143
dbj|BAB03739.1| (AP001507) inositol-monophosphate dehydrogenase ... 480 e-134
sp|P50099|IMDH_STRPY INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 478 e-134
pir||G81308 IMP dehydrogenase (EC 1.1.1.205) Cj1058c [similarity... 474 e-133
pir||F75342 IMP dehydrogenase (EC 1.1.1.205) DR1878 [similarity]... 466 e-130
pir||S66039 IMP dehydrogenase - Bacillus subtilis >gi|7427684|pi... 466 e-130
sp|P56088|IMDH_HELPY INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 461 e-129
pir||H71890 IMP dehydrogenase (EC 1.1.1.205) - Helicobacter pylo... 460 e-128
sp|O50316|IMDH_CHLVI INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 458 e-128
pdb|1ZFJ|A Chain A, Inosine Monophosphate Dehydrogenase (Impdh; ... 456 e-127
sp|P21879|IMDH_BACSU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 455 e-127
emb|CAB82009.1| (AL161755) inosine 5' monophosphate dehydrogenas... 453 e-126
pir||JC7305 IMP dehydrogenase (EC 1.1.1.205) - Bacillus cereus >... 453 e-126
dbj|BAA89464.1| (AB036795) IMPDH [Bacillus cereus] 451 e-126
pir||H81109 IMP dehydrogenase (EC 1.1.1.205) NMB1201 [similarity... 448 e-125
pir||F81906 IMP dehydrogenase (EC 1.1.1.205) NMA1372 [similarity... 445 e-124
dbj|BAA89452.1| (AB003154) IMP dehydrogenase [Corynebacterium am... 443 e-123
sp|Q50715|IMDH_MYCTU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 442 e-123
pir||H83173 inosine-5'-monophosphate dehydrogenase PA3770 [impor... 437 e-121
sp|Q49729|IMDH_MYCLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 434 e-121
gb|AAF85967.1| (AF272827) GuaB [Rhizobium tropici] 423 e-117
sp|P44334|IMDH_HAEIN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 420 e-116
gb|AAF68407.1|AF237921_1 (AF237921) inosine-5'-monophosphate deh... 419 e-116
pir||B82558 inosine-5'-monophosphate dehydrogenase XF2430 [impor... 419 e-116
sp|P06981|IMDH_ECOLI INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 418 e-116
dbj|BAA16395.1| (D90880) IMP dehydrogenase (EC 1.1.1.205) [Esche... 418 e-116
sp|P31002|IMDH_ACICA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 417 e-115
emb|CAA26133.1| (X02209) IMP dehydrogenase subunit [Escherichia ... 416 e-115
gb|AAB18618.1| (M10101) IMP dehydrogenase [Escherichia coli] 416 e-115
pir||C82282 inosine-5'-monophosphate dehydrogenase VC0767 [impor... 412 e-114
emb|CAA09265.1| (AJ010601) inosine 5' monophosphate dehydrogenas... 348 7e-95
gi|11497009 IMP dehydrogenase (guaB) [Borrelia burgdorferi] >gi|... 305 5e-82
sp|Q07152|IMDH_DROME INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 290 3e-77
pir||T40127 IMP dehydrogenase (EC 1.1.1.205) SPBC2F12.14c - fiss... 283 3e-75
pir||D72631 probable IMP dehydrogenase (EC 1.1.1.205) APE1507 [s... 277 2e-73
gb|AAF13230.1|AF196975_1 (AF196975) inosine 5'-monophosphate deh... 275 7e-73
pir||E81701 probable IMP dehydrogenase (EC 1.1.1.205) TC0443 [si... 274 1e-72
gi|6322012 IMP dehydrogenase; probable PUR5 gene; Imd2p [Sacchar... 271 1e-71
sp|O00086|IMH3_CANAL PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGE... 270 2e-71
sp|P12269|IMD2_MESAU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (I... 269 6e-71
gb|AAF70813.1|AF249293_1 (AF249293) putative inosine 5-monophosp... 268 7e-71
sp|P20839|IMD1_HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 (I... 268 1e-70
gi|4504689 IMP (inosine monophosphate) dehydrogenase 2; IMP (ino... 268 1e-70
sp|P24547|IMD2_MOUSE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (I... 268 1e-70
gi|6754344 inosine 5'-phosphate dehydrogenase 1 [Mus musculus] >... 268 1e-70
sp|P12268|IMD2_HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (I... 267 2e-70
gi|6323464 Imd3p [Saccharomyces cerevisiae] >gi|1708477|sp|P5009... 267 2e-70
gi|11419298 IMP (inosine monophosphate) dehydrogenase 1 [Homo sa... 265 8e-70
gi|6754346 inosine 5'-phosphate dehydrogenase 2; IMP dehydrogena... 264 1e-69
gb|AAD10256.1| (AF035679) inosine-5'-monophosphate dehydrogenase... 264 2e-69
gi|4504687 IMP (inosine monophosphate) dehydrogenase 1; sWSS2608... 263 4e-69
pir||S59508 IMP dehydrogenase (EC 1.1.1.205) ras - fruit fly (Dr... 257 1e-67
pir||C72109 IMP dehydrogenase homolog (EC 1.-.-.-) - Chlamydophi... 257 1e-67
gi|6323585 Imd4p [Saccharomyces cerevisiae] >gi|1708478|sp|P5009... 254 2e-66
sp|Q12658|IMDH_PNECA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 247 2e-64
pir||A38668 IMP dehydrogenase (EC 1.1.1.205) - Leishmania donovani 246 4e-64
sp|P21620|IMDH_LEIDO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 246 4e-64
sp|P50098|IMDH_TRYBB INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 241 1e-62
emb|CAB76883.1| (AL159139) putative inosine monophosphate dehydr... 232 8e-60
gb|AAD34687.1|AC006341_15 (AC006341) Strong similarity to gb|L34... 228 2e-58
dbj|BAA90835.1| (AB031209) GuaB [Bacillus halodurans] 226 3e-58
sp|P47996|IMDH_ARATH INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 219 6e-56
sp|Q50591|YI43_MYCTU HYPOTHETICAL 50.0 KDA PROTEIN RV1843C >gi|7... 213 3e-54
pir||T32709 IMP dehydrogenase (EC 1.1.1.205) T22D1.3 - Caenorhab... 212 1e-53
emb|CAB38030.1| (AJ010201) inosine monophosphate dehydrogenase [... 208 1e-52
pir||T44751 IMP dehydrogenase (EC 1.1.1.205) guaB1 [similarity] ... 206 3e-52
sp|P50097|IMDH_TRIFO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 204 2e-51
gi|6319352 Imd1p [Saccharomyces cerevisiae] >gi|731323|sp|P39567... 198 2e-49
sp|P27442|GUAC_ASCSU GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE O... 153 3e-36
gb|AAG23534.1|AF244585_1 (AF244585) IMP dehydrogenase [Carboxydo... 153 4e-36
gi|7706109 GMPR2 for guanosine monophosphate reductase isolog [H... 150 4e-35
gi|11434007 GMPR2 for guanosine monophosphate reductase isolog [... 150 4e-35
sp|O16294|GUAC_CAEEL PROBABLE GMP REDUCTASE (GUANOSINE 5'-MONOPH... 148 1e-34
sp|P57300|GUAC_BUCAI GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE O... 147 3e-34
gi|11321611 guanosine monophosphate reductase; guanine monophosp... 145 1e-33
sp|P36959|GUAC_HUMAN GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE O... 145 1e-33
pir||F82490 GMP reductase VCA0197 [imported] - Vibrio cholerae (... 145 1e-33
gb|AAF64252.1|AF153721_1 (AF153721) GMP-reductase GMR-1 [Onchoce... 144 2e-33
sp|Q9Z244|GUAC_RAT GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE OXI... 143 3e-33
pir||H64732 GMP reductase (EC 1.6.6.8) - Escherichia coli >gi|17... 140 4e-32
emb|CAA15623.1| (AL009031) GMP reductase (Guanosine 5'-monophosp... 139 5e-32
sp|P15344|GUAC_ECOLI GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE O... 134 2e-30
pir||T42083 IMP dehydrogenase (EC 1.1.1.205) - fission yeast (Sc... 132 1e-29
gb|AAC21895.1| (U32708) H. influenzae predicted coding region HI... 126 6e-28
pir||F64626 probable GMP reductase (EC 1.6.6.8) - Helicobacter p... 122 7e-27
pir||A71887 probable GMP reductase (EC 1.6.6.8) - Helicobacter p... 121 2e-26
pir||C70015 probable GMP reductase (EC 1.6.6.8) yumD - Bacillus ... 119 8e-26
prf||1110192A gene gua [Escherichia coli] 112 1e-23
pir||S75050 IMP dehydrogenase homolog (EC 1.-.-.-) guaB - Synech... 110 3e-23
pir||H72290 conserved hypothetical protein - Thermotoga maritima... 90 6e-17
emb|CAB82010.1| (AL161755) putative inosine-5'-monophosphate deh... 89 1e-16
sp|P50100|IMDH_METKA PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGE... 86 7e-16
gb|AAK42850.1| Conserved hypothetical protein [Sulfolobus solfat... 83 5e-15
sp|Q58629|YC32_METJA HYPOTHETICAL PROTEIN MJ1232 >gi|2128738|pir... 82 2e-14
pir||F72780 hypothetical protein APE0231 - Aeropyrum pernix (str... 81 3e-14
pir||F69037 MJ0188 homolog - Methanobacterium thermoautotrophicu... 80 4e-14
pir||G75056 dehydrogenase PAB0961 - Pyrococcus abyssi (strain Or... 80 4e-14
pir||D71175 hypothetical protein PH0600 - Pyrococcus horikoshii ... 79 9e-14
emb|CAB97003.1| (AJ293460) IMP dehydrogenase [Schizosaccharomyce... 78 3e-13
pir||S70312 hypothetical protein YAR075w - yeast (Saccharomyces ... 77 5e-13
gi|6319353 Yar075wp [Saccharomyces cerevisiae] >gi|7429666|pir||... 77 5e-13
gi|11497944 conserved hypothetical protein [Archaeoglobus fulgid... 76 6e-13
pir||B72265 hypothetical protein TM1354 - Thermotoga maritima (s... 76 8e-13
sp|Q58069|Y653_METJA HYPOTHETICAL PROTEIN MJ0653 >gi|2128024|pir... 76 1e-12
pir||B69077 yhcV homolog 2 - Methanobacterium thermoautotrophicu... 76 1e-12
pir||A70340 conserved hypothetical protein aq_438 - Aquifex aeol... 75 1e-12
pir||D69035 MJ1232 protein homolog MTH126 - Methanobacterium the... 75 2e-12
gb|AAG19149.1| (AE005012) inosine-5'-monophosphate dehydrogenase... 75 2e-12
gi|11498786 conserved hypothetical protein [Archaeoglobus fulgid... 74 3e-12
gi|11497682 conserved hypothetical protein [Archaeoglobus fulgid... 73 5e-12
pir||C75148 hypothetical protein PAB2118 - Pyrococcus abyssi (st... 73 7e-12
sp|P54606|YHCV_BACSU HYPOTHETICAL 14.9 KD PROTEIN IN CSPB-GLPP I... 72 1e-11
gi|11499010 chloride channel, putative [Archaeoglobus fulgidus] ... 71 4e-11
pir||H75197 yhcV homolog PAB2277 - Pyrococcus abyssi (strain Ors... 70 5e-11
sp|Q57647|Y188_METJA HYPOTHETICAL PROTEIN MJ0188 >gi|2128173|pir... 70 6e-11
>pir||E75015 IMP dehydrogenase (EC 1.1.1.205) PAB1250 - Pyrococcus abyssi
(strain Orsay) >gi|5459077|emb|CAB50563.1| (AJ248288)
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205)
(IMP DEHYDROGENASE) (IMPDH) (IMPD). [Pyrococcus abyssi]
Length = 485
Score = 949 bits (2425), Expect = 0.0
Identities = 485/485 (100%), Positives = 485/485 (100%)
Query: 1 MGKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE 60
MGKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE
Sbjct: 1 MGKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE 60
Query: 61 WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLME 120
WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLME
Sbjct: 61 WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLME 120
Query: 121 KHDIDGLPVVENEKVVGIISKKDIAAREGKLVKELMTKDVITVPENIEVEEALKIMIENR 180
KHDIDGLPVVENEKVVGIISKKDIAAREGKLVKELMTKDVITVPENIEVEEALKIMIENR
Sbjct: 121 KHDIDGLPVVENEKVVGIISKKDIAAREGKLVKELMTKDVITVPENIEVEEALKIMIENR 180
Query: 181 IDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAG 240
IDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAG
Sbjct: 181 IDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAG 240
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSI 300
ADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSI
Sbjct: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSI 300
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL
Sbjct: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY
Sbjct: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN
Sbjct: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
Query: 481 YPLEK 485
YPLEK
Sbjct: 481 YPLEK 485
>sp|O58045|IMDH_PYRHO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|7427688|pir||E71456 IMP dehydrogenase (EC
1.1.1.205) - Pyrococcus horikoshii
>gi|3256697|dbj|BAA29380.1| (AP000001) 486aa long
hypothetical inosine-5'-monophosphate dehydrogenase
[Pyrococcus horikoshii]
Length = 486
Score = 908 bits (2321), Expect = 0.0
Identities = 456/485 (94%), Positives = 478/485 (98%)
Query: 1 MGKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE 60
MGKF +KLE+AI+GYTFDDVLLIPQATEVEPKDVDVST+ITPNVKLNIPILSAAMDTVTE
Sbjct: 1 MGKFVEKLEKAIKGYTFDDVLLIPQATEVEPKDVDVSTRITPNVKLNIPILSAAMDTVTE 60
Query: 61 WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLME 120
WEMAVAMAREGGLGVIHRNM IEEQVEQVKRVK+AER IVEDVITI+P+ETVDFALFLME
Sbjct: 61 WEMAVAMAREGGLGVIHRNMGIEEQVEQVKRVKRAERLIVEDVITIAPDETVDFALFLME 120
Query: 121 KHDIDGLPVVENEKVVGIISKKDIAAREGKLVKELMTKDVITVPENIEVEEALKIMIENR 180
KH IDGLPVVE+EKVVGII+KKDIAAREGKLVKELMTK+VITVPE+IEVEEALKIMIENR
Sbjct: 121 KHGIDGLPVVEDEKVVGIITKKDIAAREGKLVKELMTKEVITVPESIEVEEALKIMIENR 180
Query: 181 IDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAG 240
IDRLPVVD+ G+L+GLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDI+RAIELD+AG
Sbjct: 181 IDRLPVVDERGKLVGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIKRAIELDKAG 240
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSI 300
DVIVVDTAHAHNLKAIK+MKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSI
Sbjct: 241 VDVIVVDTAHAHNLKAIKSMKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSI 300
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTRIVAGVGVPQITA+AMVADRAQEYGLYVIADGGI+YSGDIVKAIAAGADAVMLGNLL
Sbjct: 301 CTTRIVAGVGVPQITAVAMVADRAQEYGLYVIADGGIRYSGDIVKAIAAGADAVMLGNLL 360
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY
Sbjct: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
RGTVSEVLYQLVGGLKAGMGYVGARNI+ELKEKGEFVIIT AG++ESHPHDIIITNEAPN
Sbjct: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIRELKEKGEFVIITHAGIKESHPHDIIITNEAPN 480
Query: 481 YPLEK 485
YPLEK
Sbjct: 481 YPLEK 485
>sp|P42851|IMDH_PYRFU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|2117506|pir||JC4998 IMP dehydrogenase (EC
1.1.1.205) - Pyrococcus furiosus
>gi|595287|gb|AAC44532.1| (U08814) IMP dehydrogenase
[Pyrococcus furiosus]
Length = 485
Score = 901 bits (2303), Expect = 0.0
Identities = 452/485 (93%), Positives = 476/485 (97%)
Query: 1 MGKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE 60
MGKF +KLE AIRGYTFDDVLLIPQ TEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE
Sbjct: 1 MGKFVEKLENAIRGYTFDDVLLIPQPTEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE 60
Query: 61 WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLME 120
WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVK+AERFIVEDVITI+P+ET+D+ALFLME
Sbjct: 61 WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLME 120
Query: 121 KHDIDGLPVVENEKVVGIISKKDIAAREGKLVKELMTKDVITVPENIEVEEALKIMIENR 180
KH IDGLPVVE ++VVGII+KKDIAAREG+ VKELMT++VITVPE+++VEEALKIM+ENR
Sbjct: 121 KHGIDGLPVVEEDRVVGIITKKDIAAREGRTVKELMTREVITVPESVDVEEALKIMMENR 180
Query: 181 IDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAG 240
IDRLPVV+++G+L+GLITMSDLVARKKYKNAVR+E GELLVAAAVSPFD+RRAIELDRAG
Sbjct: 181 IDRLPVVNEDGKLVGLITMSDLVARKKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAG 240
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSI 300
DVIVVDTAHAHNLKAIKAMKEMRQKV ADFIVGNIANPKAVDDLTFADAVKVGIGPGSI
Sbjct: 241 VDVIVVDTAHAHNLKAIKAMKEMRQKVSADFIVGNIANPKAVDDLTFADAVKVGIGPGSI 300
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL
Sbjct: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY
Sbjct: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN
Sbjct: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
Query: 481 YPLEK 485
YPLE+
Sbjct: 481 YPLER 485
>sp|Q59011|IMDH_METJA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|2117504|pir||G64501 IMP dehydrogenase (EC
1.1.1.205) - Methanococcus jannaschii
>gi|1592337|gb|AAB99638.1| (U67602)
inosine-5'-monophosphate dehydrogenase, (guaB)
[Methanococcus jannaschii]
Length = 496
Score = 598 bits (1526), Expect = e-170
Identities = 312/496 (62%), Positives = 385/496 (76%), Gaps = 15/496 (3%)
Query: 4 FAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEM 63
F KKL A + YTFDDVLL+P A+ VEPKD DVST + +KLNIPI+SAAMDTVTE EM
Sbjct: 2 FLKKLIEAKKAYTFDDVLLVPNASWVEPKDTDVSTDLA-GLKLNIPIVSAAMDTVTEKEM 60
Query: 64 AVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHD 123
A+A+AR GGLGVIHRNMSIEEQV QV+ VKKA+ +++DVIT+SP++TV A+ +ME +
Sbjct: 61 AIALARLGGLGVIHRNMSIEEQVHQVQAVKKADEVVIKDVITVSPDDTVGEAINVMETYS 120
Query: 124 IDGLPVVENE-KVVGIISKKDIAAREGKL--VKELMTKDVITVPENIEVEEALKIMIENR 180
I GLPVV+NE K+VGII+ +D+ A E K VK++MTKDV+ E++E EEAL++M NR
Sbjct: 121 ISGLPVVDNEDKLVGIITHRDVKAIEDKTKKVKDVMTKDVVCAKEDVEEEEALELMYANR 180
Query: 181 IDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAG 240
++RLP+VD E RLIG+IT+ D++ R+KY A RD+ G LLVAAA P D RA L A
Sbjct: 181 VERLPIVDDENRLIGIITLRDILKRRKYPQAARDKKGRLLVAAACGPHDFERAKALIEAE 240
Query: 241 ADVIVVDTAHAHNLKAI---KAMKEMRQKVDADFIVGNIANPKAVDDL--TFADAVKVGI 295
D I +D AHAHN++ + K KEM + D IVGNIA +A +DL AD +KVGI
Sbjct: 241 VDAIAIDCAHAHNMRVVENVKKFKEMLEGTDIKLIVGNIATKEAAEDLIKAGADVLKVGI 300
Query: 296 GPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVM 355
GPGSICTTR+VAGVGVPQ+TA+A VAD A+E+ + +IADGGI+YSGDI KAIAAGADAVM
Sbjct: 301 GPGSICTTRVVAGVGVPQLTAVAEVADVAKEHNVPIIADGGIRYSGDIAKAIAAGADAVM 360
Query: 356 LGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKG---GAERYYQG---GYMKTRKF 409
LG+LLAGT EAPG+ ++INGRKYKQYRGMGSLGAM G GA+RY+Q +MK K
Sbjct: 361 LGSLLAGTDEAPGQLMVINGRKYKQYRGMGSLGAMTGGVGAGADRYFQAPAKSHMKHVKL 420
Query: 410 VPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHP 469
VPEGVEG VPY+G VSEV++QL+GGL+A MGY GA+N+KE++EK FVIIT +G ESHP
Sbjct: 421 VPEGVEGAVPYKGPVSEVVFQLIGGLRASMGYCGAKNLKEMQEKARFVIITPSGQVESHP 480
Query: 470 HDIIITNEAPNYPLEK 485
HDIIITNEAPNYPL K
Sbjct: 481 HDIIITNEAPNYPLGK 496
>emb|CAC11365.1| (AL445063) probable inosine-5'-monophosphate dehydrogenase
[Thermoplasma acidophilum]
Length = 485
Score = 561 bits (1431), Expect = e-159
Identities = 275/483 (56%), Positives = 376/483 (76%), Gaps = 7/483 (1%)
Query: 4 FAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEM 63
+ +K + G+TFDDVLLIP T VEPK+V VS++I+ ++++ +PI+S+ MDTVTE M
Sbjct: 2 YREKFTKITEGFTFDDVLLIPMRTAVEPKNVVVSSRISRHIQVKVPIVSSPMDTVTEDAM 61
Query: 64 AVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHD 123
A+AMAR G +GVIHRN E++VE VKRVK+ E I+ DV TISPE ++ A LM +
Sbjct: 62 AIAMARYGAIGVIHRNQPREKEVEMVKRVKREETIIIRDVYTISPETPIEVARTLMATRN 121
Query: 124 IDGLPVVENEKVVGIISKKDIA-AREGKLVKELMTKDVITVPENIEVEEALKIMIENRID 182
I GLPVV+++K+VGI++K+D+ ++G V ++M +DVIT PEN++++EA++I+ +NRI+
Sbjct: 122 IAGLPVVKDDKLVGIVTKRDLEFVKKGSSVSDVMVRDVITAPENVDIDEAIEILHKNRIE 181
Query: 183 RLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGAD 242
+LP+VD G L+GLIT D++ R+K+ +A RD G+L+V AAV PFD+ RA+E+++AGAD
Sbjct: 182 KLPLVDSSGHLVGLITAKDIITRQKFPDASRDSEGQLMVGAAVGPFDLDRAVEVEKAGAD 241
Query: 243 VIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFADA--VKVGIGPGSI 300
IVVDTAHA N + ++K+MR+++ D + GNIA +A +DL D ++VGIGPGSI
Sbjct: 242 FIVVDTAHADNENVLSSLKKMRKQISVDIVAGNIATAQAAEDLISCDVDGLRVGIGPGSI 301
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTRIVAGVGVPQ+TAI+ VA+ A++ G+ VIADGGI+YSGDIVKAIAAGADAVMLG++L
Sbjct: 302 CTTRIVAGVGVPQLTAISDVAEAAKDSGIPVIADGGIRYSGDIVKAIAAGADAVMLGSML 361
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AGT+E+PG+E+IINGRKYK YRGMGS+GA+ G ++RY + G F+ EGVEG VPY
Sbjct: 362 AGTEESPGQEMIINGRKYKAYRGMGSIGALTTGLSDRYSKLG----NGFIAEGVEGAVPY 417
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
RG V EVL+QLVGGL+ GMGYVGA I++LK G+FV IT+ GLRESHPHDI + +E PN
Sbjct: 418 RGRVDEVLFQLVGGLRTGMGYVGAATIEDLKRNGKFVRITNNGLRESHPHDIRLISEPPN 477
Query: 481 YPL 483
Y +
Sbjct: 478 YQI 480
>pir||B69056 IMP dehydrogenase (EC 1.1.1.205) - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621183|gb|AAB84648.1| (AE000803)
inosine-5'-monophosphate dehydrogenase [Methanobacterium
thermoautotrophicum]
Length = 484
Score = 558 bits (1422), Expect = e-158
Identities = 283/477 (59%), Positives = 369/477 (77%), Gaps = 12/477 (2%)
Query: 4 FAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEM 63
+ KKL A GYTFDD LL+PQA+ VEP+DV+ + +++ N++L IP++S+AMDTVTE++M
Sbjct: 2 YRKKLTEAETGYTFDDFLLLPQASYVEPRDVETAGRVSRNIELKIPVISSAMDTVTEYDM 61
Query: 64 AVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHD 123
A+AMA+EGG+GVIHRNMSI +QVEQVK+VK++ + DVITISP+ T+ A +M++ +
Sbjct: 62 AIAMAQEGGMGVIHRNMSIRDQVEQVKKVKRSGDITIRDVITISPDSTLREAHEIMDQEE 121
Query: 124 IDGLPVVENEKVVGIISKKDIA----AREGKLVKELMTKDVITVPENIEVEEALKIMIEN 179
I GLPVVE+ ++GIIS++DI + K V ++MT+DV+TV E+I EAL I EN
Sbjct: 122 ISGLPVVEDGVLIGIISRRDIEPIFNSDADKKVDQVMTRDVVTVDESITPNEALDIAYEN 181
Query: 180 RIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRA 239
+++RLPVV K+GR++G++TM D++ RK+Y NA RD G L VAAA PFD+ RA LD A
Sbjct: 182 KVERLPVV-KDGRIVGMLTMKDILERKRYPNASRDSEGYLRVAAATGPFDLERARALDEA 240
Query: 240 GADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTF--ADAVKVGIGP 297
GADV+ +D+AH HN+ +K+ M+++++AD IVGNIA +A +DL D +KVGIGP
Sbjct: 241 GADVLAIDSAHGHNMNLVKSAGAMKKEIEADLIVGNIATREAAEDLIAQDVDGLKVGIGP 300
Query: 298 GSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLG 357
GS+CTTRI+AGVGVPQ+TAIA VAD A EYG+ VIADGGI+YSGDI KAIA GAD VMLG
Sbjct: 301 GSMCTTRIIAGVGVPQLTAIAEVADVAAEYGVPVIADGGIRYSGDIAKAIAVGADCVMLG 360
Query: 358 NLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKG---GAERYYQ--GGYMKTRKFVPE 412
NLLAGT EAPG V++NGRKYKQYRGMGSLGAM G G +RY+Q G+MK K VPE
Sbjct: 361 NLLAGTYEAPGDVVVMNGRKYKQYRGMGSLGAMTGGIGAGTDRYFQEPRGHMKHTKVVPE 420
Query: 413 GVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHP 469
GVEGVVPYRGTVSEVL+QL+GGL+A MGY GA N+ E+KE+ + V ITS+G + P
Sbjct: 421 GVEGVVPYRGTVSEVLFQLIGGLRASMGYCGAANLSEMKERAKLVRITSSGYQGEPP 477
>gb|AAG19418.1| (AE005036) inosine monophosphate dehydrogenase; GuaB [Halobacterium
sp. NRC-1]
Length = 527
Score = 518 bits (1320), Expect = e-146
Identities = 257/488 (52%), Positives = 358/488 (72%), Gaps = 10/488 (2%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G+F++KL R TFDDVLL P + VEP D DV+T+++ NV+L +P+LSAAMDTVTE
Sbjct: 37 GRFSEKL-RVPEALTFDDVLLRPAESRVEPDDADVATRVSTNVELEVPVLSAAMDTVTES 95
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIV--EDVITISPEETVDFALFLM 119
+A+AMAREGGLGV+H+NM + V +V+RVK+A+ ++ E+V+T +PE+TV+ +M
Sbjct: 96 RLAIAMAREGGLGVLHQNMDTDRVVAEVERVKRADELVIDRENVVTAAPEQTVEAVDEMM 155
Query: 120 EKHDIDGLPVVENEKVV-GIISKKDIA----AREGKLVKELMTKDVITVPENIEVEEALK 174
++ D+ G PVV+++ V GIIS DI E V+E MT +VIT PE+I +AL+
Sbjct: 156 DRSDVSGAPVVDDDDTVRGIISATDIRPYLEVGESDAVREAMTDEVITAPEDITARDALE 215
Query: 175 IMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAI 234
+M E++I+R+P+V+ E L+GL+TM ++ R+++ +A RD+NG L V AV PFD RA
Sbjct: 216 LMYEHKIERVPIVNDEQHLVGLVTMQGILERREHGSAARDQNGRLRVGVAVGPFDTERAT 275
Query: 235 ELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLT-FADAVKV 293
+D AGADV+ +D AHAHNL I + +E++ VDAD +VGN+ +A + + FAD +KV
Sbjct: 276 AVDEAGADVLFIDCAHAHNLNVIDSAREIKASVDADVVVGNVGTREAAEAVVDFADGIKV 335
Query: 294 GIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADA 353
GIGPGSICTTR+V G G+PQITA++ VAD A G+ VIADGGI+YSGD KAIAAGADA
Sbjct: 336 GIGPGSICTTRVVTGSGMPQITAVSQVADVAAPAGVPVIADGGIRYSGDAAKAIAAGADA 395
Query: 354 VMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEG 413
VMLG+ AGT EAPG+ + +NG+KYKQYRGMGS+GAM GG++RY + + ++VPEG
Sbjct: 396 VMLGSYFAGTDEAPGRVITMNGKKYKQYRGMGSVGAMQSGGSDRYLKDD-DEDEEYVPEG 454
Query: 414 VEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDII 473
VE PY+G+++ L+QLVGG+++GMGYVGA +I K EFV +++AG E HPHD++
Sbjct: 455 VEAATPYKGSLASELHQLVGGIQSGMGYVGAESIPAFKADAEFVRVSAAGQTEGHPHDVM 514
Query: 474 ITNEAPNY 481
IT+EAPNY
Sbjct: 515 ITDEAPNY 522
>sp|O67820|IMDH_AQUAE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|7427683|pir||H70473 IMP dehydrogenase (EC
1.1.1.205) - Aquifex aeolicus >gi|2984252|gb|AAC07779.1|
(AE000768) inosine monophosphate dehydrogenase [Aquifex
aeolicus]
Length = 490
Score = 511 bits (1303), Expect = e-144
Identities = 272/488 (55%), Positives = 364/488 (73%), Gaps = 16/488 (3%)
Query: 7 KLERAIR-GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAV 65
++E+ I+ G TFDDVLL+PQ +EV P +VDVST +T +KLNIPI+SAAMDTVTE +A+
Sbjct: 3 EVEKKIKEGLTFDDVLLVPQYSEVLPHEVDVSTYLTKRIKLNIPIVSAAMDTVTEARLAI 62
Query: 66 AMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDID 125
A+AREGG+G+IHRN+ I++Q E+V++VKK+E ++ + +T+ P+ V AL +M K+ I
Sbjct: 63 ALAREGGIGIIHRNLPIKKQAEEVEKVKKSESGMIINPVTVKPDTRVKEALDIMAKYKIS 122
Query: 126 GLPVVENE-KVVGIISKKDIAARE----GKLVKELMTKD-VITVPENIEVEEALKIMIEN 179
G+PVV+ E K++GI++ +D+ + K V E MTK+ +IT PE I ++EA +I +
Sbjct: 123 GVPVVDEERKLIGILTNRDLRFIKPEDYSKPVSEFMTKENLITAPEGITLDEAEEIFRKY 182
Query: 180 RIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD--IRRAIELD 237
+I++LP+VDKEG++ GLIT+ D+V RKKY NA +DE G L V AAV + + R L
Sbjct: 183 KIEKLPIVDKEGKIKGLITIKDIVKRKKYPNACKDELGRLRVGAAVGTGEETLDRVAALV 242
Query: 238 RAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAVKVG 294
AG DVIVVDTAH H+ + ++ +++++ + D I GN+A + L ADAVKVG
Sbjct: 243 EAGVDVIVVDTAHGHSKRVLETVEKIKANFPEVDVIAGNVATAEGTKALIEAGADAVKVG 302
Query: 295 IGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAV 354
+GPGSICTTRIVAGVGVPQ+TAI A A+EY + +IADGGI+YSGDIVKA+AAGA AV
Sbjct: 303 VGPGSICTTRIVAGVGVPQLTAIMEAASAAREYDIPIIADGGIRYSGDIVKALAAGASAV 362
Query: 355 MLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAM-MKGGAERYYQGGYMKTRKFVPEG 413
MLGNLLAGT+EAPG+ + GR YK YRGMGSLGAM + ++RY G K KFVPEG
Sbjct: 363 MLGNLLAGTEEAPGETIYYQGRAYKVYRGMGSLGAMSSRLSSDRY---GQEKMEKFVPEG 419
Query: 414 VEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDII 473
+EG VPY+G +++V+YQLVGGL++GMGYVGARNIKEL+EK +FV IT AG RESH HD+
Sbjct: 420 IEGRVPYKGKLADVVYQLVGGLRSGMGYVGARNIKELQEKAKFVRITWAGYRESHVHDVQ 479
Query: 474 ITNEAPNY 481
IT EAPNY
Sbjct: 480 ITREAPNY 487
>pir||C72264 IMP dehydrogenase (EC 1.1.1.205) - Thermotoga maritima (strain
MSB8) >gi|4981907|gb|AAD36418.1|AE001789_3 (AE001789)
inosine-5'-monophosphate dehydrogenase [Thermotoga
maritima]
Length = 482
Score = 509 bits (1296), Expect = e-143
Identities = 256/476 (53%), Positives = 363/476 (75%), Gaps = 13/476 (2%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLL+PQ +EV PKDV + T++T +++NIP++SAAMDTVTE +A A+AREGG+G+
Sbjct: 6 TFDDVLLVPQYSEVLPKDVKIDTRLTRQIRINIPLVSAAMDTVTEAALAKALAREGGIGI 65
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE-K 134
IH+N++ +EQ QV VKK E I+ D IT++P+ TV A+ LM ++ I GLPVV+ E +
Sbjct: 66 IHKNLTPDEQARQVSIVKKTENGIIYDPITVTPDMTVKEAIDLMAEYKIGGLPVVDEEGR 125
Query: 135 VVGIISKKDIAAREG--KLVKELMT--KDVITVPENIEVEEALKIMIENRIDRLPVVDKE 190
+VG+++ +D+ + K +K+LMT + +I P +I +E+A +I+ ++RI++LP+V K+
Sbjct: 126 LVGLLTNRDVRFEKNLSKKIKDLMTPREKLIVAPPDISLEKAKEILHQHRIEKLPLVSKD 185
Query: 191 GRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV--SPFDIRRAIELDRAGADVIVVDT 248
+L+GLIT+ D+++ ++ NA RDE G LLV AAV SP + R +L +AG DVIV+DT
Sbjct: 186 NKLVGLITIKDIMSVIEHPNAARDEKGRLLVGAAVGTSPETMERVEKLVKAGVDVIVIDT 245
Query: 249 AHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAVKVGIGPGSICTTRI 305
AH H+ + I+ ++ ++ D + GN+A P+ + L ADAVKVG+GPGSICTTR+
Sbjct: 246 AHGHSRRVIETLEMIKADYPDLPVVAGNVATPEGTEALIKAGADAVKVGVGPGSICTTRV 305
Query: 306 VAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKE 365
VAGVGVPQ+TA+ ++ A++Y + +IADGGI+YSGDIVKA+AAGA++VM+G++ AGT+E
Sbjct: 306 VAGVGVPQLTAVMECSEVARKYDVPIIADGGIRYSGDIVKALAAGAESVMVGSIFAGTEE 365
Query: 366 APGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVS 425
APG+ ++ GRKYK YRGMGSLGAM G A+RY Q G KFVPEG+EG+VPY+GTV
Sbjct: 366 APGETILYQGRKYKAYRGMGSLGAMRSGSADRYGQEG---ENKFVPEGIEGMVPYKGTVK 422
Query: 426 EVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
+V++QLVGGL++GMGY+GAR IKEL+EK FV IT AG++ESHPHDIIIT E+PNY
Sbjct: 423 DVVHQLVGGLRSGMGYIGARTIKELQEKAVFVKITPAGVKESHPHDIIITKESPNY 478
>dbj|BAB03739.1| (AP001507) inositol-monophosphate dehydrogenase [Bacillus
halodurans]
Length = 485
Score = 480 bits (1223), Expect = e-134
Identities = 251/480 (52%), Positives = 350/480 (72%), Gaps = 14/480 (2%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G TFDDVLL+P +EV P+DV V T++T ++LNIPI+SA MDTVTE +MA+A+AREGGL
Sbjct: 10 GLTFDDVLLVPAKSEVLPRDVSVKTKLTETLQLNIPIISAGMDTVTEAKMAIAIAREGGL 69
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV-EN 132
G+IH+NMS+EEQ EQV RVK++E ++ + ++P+ V A LM K+ I G+P+V E+
Sbjct: 70 GIIHKNMSVEEQAEQVDRVKRSESGVITNPFFLTPDRQVFDAEHLMGKYRISGVPIVDED 129
Query: 133 EKVVGIISKKDIAARE--GKLVKELMTKD-VITVPENIEVEEALKIMIENRIDRLPVVDK 189
+K+VGI++ +D+ E L+ ++MTK+ ++T P ++EA +I+ +++I++LP+VD+
Sbjct: 130 QKLVGILTNRDLRFIEDYSTLIDDVMTKENLVTAPVGTTLKEAEEILQKHKIEKLPLVDE 189
Query: 190 EGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV---SPFDIRRAIELDRAGADVIVV 246
G L GLIT+ D+ ++ N+ +D G L+V AAV + D+R A L AG DVIV+
Sbjct: 190 SGTLKGLITIKDIEKVIEFPNSAKDSQGRLIVGAAVGVSADTDVRVAA-LVEAGVDVIVI 248
Query: 247 DTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFADA--VKVGIGPGSICTT 303
DTAH H+ ++ +K +R++ D I GN+A +A DL A A VKVGIGPGSICTT
Sbjct: 249 DTAHGHSKGVLEKVKAIREQYPDLTIIAGNVATAEATRDLIEAGANVVKVGIGPGSICTT 308
Query: 304 RIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGT 363
RIVAG+GVPQITA+ A+ A+++G+ +IADGGIKYSGDIVKA+AAG AVMLG+LLAG
Sbjct: 309 RIVAGIGVPQITAVYDCANEARKHGVPIIADGGIKYSGDIVKALAAGGHAVMLGSLLAGV 368
Query: 364 KEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGT 423
E+PG+ I GR++K YRGMGSLGAM KG +RY+Q +K VPEG+EG +PY+G
Sbjct: 369 SESPGEREIFQGRQFKVYRGMGSLGAMEKGSKDRYFQ---ENNQKLVPEGIEGRIPYKGP 425
Query: 424 VSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNYPL 483
+ + ++QLVGG++AGMGY G + I EL+E +F+ IT AGLRESHPHD+ IT EAPNY L
Sbjct: 426 LHDTIHQLVGGIRAGMGYCGTKTIDELRENTQFIRITGAGLRESHPHDVQITKEAPNYTL 485
>sp|P50099|IMDH_STRPY INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|2117503|pir||JC4372 IMP dehydrogenase (EC
1.1.1.205) - Streptococcus pyogenes
>gi|924848|gb|AAB03846.1| (U26056) inosine monophosphate
dehydrogenase [Streptococcus pyogenes]
Length = 493
Score = 478 bits (1216), Expect = e-134
Identities = 253/490 (51%), Positives = 344/490 (69%), Gaps = 17/490 (3%)
Query: 3 KFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWE 62
KF KK GYTFDDVLLIP + V P +VD+ T++ N+ LNIPI++AAMDTVT +
Sbjct: 7 KFLKK------GYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAMDTVTGSK 60
Query: 63 MAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKH 122
MA+A+AR GGLGVIH+NMSI EQ E+V++VK++E ++ D ++PE V A LM+++
Sbjct: 61 MAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRY 120
Query: 123 DIDGLPVVE---NEKVVGIISKKD---IAAREGKLVKELMTKDVITVPENIEVEEALKIM 176
I G+P+VE N K+VGII+ +D I+ + + + ++ ++T ++E A +I+
Sbjct: 121 RISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMTSEHLVTAAVGTDLETAERIL 180
Query: 177 IENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD--IRRAI 234
E+RI++LP+VD GRL GLIT+ D+ ++ +A +DE G LLVAAAV RA
Sbjct: 181 HEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAE 240
Query: 235 ELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAV 291
L AGAD IV+DTAH H+ ++ + E+R + I GNIA + L A D V
Sbjct: 241 ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVV 300
Query: 292 KVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGA 351
KVGIGPGSICTTR+VAGVGVPQ+TAI A A+EYG +IADGGIKYSGDIVKA+AAG
Sbjct: 301 KVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG 360
Query: 352 DAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVP 411
+AVMLG++ AGT EAPG+ I GRK+K YRGMGS+ AM KG ++RY+QG + K VP
Sbjct: 361 NAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVP 420
Query: 412 EGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHD 471
EG+EG V Y+G S++++Q++GG+++GMGYVGA +I+EL E +FV ++ AGL ESHPHD
Sbjct: 421 EGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHD 480
Query: 472 IIITNEAPNY 481
+ ITNEAPNY
Sbjct: 481 VQITNEAPNY 490
>pir||G81308 IMP dehydrogenase (EC 1.1.1.205) Cj1058c [similarity] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968494|emb|CAB73314.1| (AL139077)
inosine-5'-monophosphate dehydrogenase [Campylobacter
jejuni]
Length = 485
Score = 474 bits (1207), Expect = e-133
Identities = 249/476 (52%), Positives = 344/476 (71%), Gaps = 8/476 (1%)
Query: 13 RGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGG 72
R TF+DVLL P +EV PK+V + T++T N+ LN+P++SAAMDTVTE A+ MAR GG
Sbjct: 6 RALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMMARLGG 65
Query: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV-E 131
LGVIH+NM I QV +VKRVKK+E ++ D I +SP+ +V AL +M ++ I G+PVV E
Sbjct: 66 LGVIHKNMDIASQVREVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDE 125
Query: 132 NEKVVGIISKKDIAARE--GKLVKELMTK-DVITVPENIEVEEALKIMIENRIDRLPVVD 188
++K++GI++ +D+ LV+ +MTK +IT P+ +++A KI N++++LP+VD
Sbjct: 126 DKKLIGILTNRDLRFESDFSNLVENVMTKMPLITAPKGCTLDDAEKIFSTNKVEKLPIVD 185
Query: 189 KEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDT 248
++GRL GLIT+ DL RK+Y +A +D G L V AA+ + R L AG DV+V+D+
Sbjct: 186 EQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDVVVLDS 245
Query: 249 AHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTTRI 305
AH H+ I +K ++ K + D I GNIA A L A DAVKVGIGPGSICTTRI
Sbjct: 246 AHGHSKGIIDTVKAIKAKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRI 305
Query: 306 VAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKE 365
V+GVGVPQI+AI + A ++G+ VIADGGIKYSGDI KA+A GA +VM+G+LLAGT E
Sbjct: 306 VSGVGVPQISAIDECVEEANKFGVPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDE 365
Query: 366 APGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVS 425
+PG+ GR+YK YRGMGSLGAM KG ++RY+Q G + K VPEG+EG VPY G++
Sbjct: 366 SPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQQGTAQD-KLVPEGIEGRVPYVGSIR 424
Query: 426 EVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
V++QL+GGL++ MGYVGA++I++ +++ EFV IT+AGL+ESH HD+ IT+EAPNY
Sbjct: 425 SVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY 480
>pir||F75342 IMP dehydrogenase (EC 1.1.1.205) DR1878 [similarity] - Deinococcus
radiodurans (strain R1)
>gi|6459660|gb|AAF11432.1|AE002027_5 (AE002027)
inosine-5`-monophosphate dehydrogenase [Deinococcus
radiodurans]
Length = 500
Score = 466 bits (1187), Expect = e-130
Identities = 251/479 (52%), Positives = 341/479 (70%), Gaps = 12/479 (2%)
Query: 11 AIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMARE 70
A G TFDDVLL P+ ++V P +VDVS Q+T V+LNIP +SAAMDTVTE MA+AMARE
Sbjct: 23 AQEGITFDDVLLQPRHSQVLPHEVDVSAQLTRRVRLNIPFVSAAMDTVTETNMAIAMARE 82
Query: 71 GGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV 130
GG+GV+H+NMSI+ Q E +++VK++E ++ D IT+ P TV A LM ++ I G+PV
Sbjct: 83 GGIGVVHKNMSIDAQAEMIRKVKRSESGMIVDPITLPPSATVRDADRLMGEYRISGVPVT 142
Query: 131 ENE-KVVGIISKKDIAAREGKLVK--ELMTKD-VITVPENIEVEEALKIMIENRIDRLPV 186
+ K++GII+ +D+ + V ++MT++ ++TVP ++E+A ++ NRI++L V
Sbjct: 143 APDGKLLGIITNRDMRFIDDLDVPLGDVMTREHLVTVPVGTDLEQARELFKLNRIEKLLV 202
Query: 187 VDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAA--VSPFDIRRAIELDRAGADVI 244
+ E L GLIT+ D+ KY NA +D+ G L VAAA VS + RA L +AGADV+
Sbjct: 203 TEGE-YLRGLITIKDIEKSVKYPNAAKDDLGRLRVAAAIGVSADLMDRAGALVQAGADVL 261
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICT 302
V+D+AH H+ + A+ ++++ D D I GN+A DL A DAVKVGIGPGSICT
Sbjct: 262 VLDSAHGHSQGILNALSRVKEQFDVDVIAGNVATRSGARDLILAGADAVKVGIGPGSICT 321
Query: 303 TRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAG 362
TR+V GVGVPQ+TAI + A E G+ VIADGGIK +GD+ KAIAAGA VM+G++LAG
Sbjct: 322 TRVVTGVGVPQVTAIFEASAAAMEAGIPVIADGGIKQTGDVPKAIAAGASVVMMGSMLAG 381
Query: 363 TKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRG 422
T EAPG+ ++ +GR+YK YRGMGSLGAM +G A+RY+QGG +RKFVPEG+EG++ YRG
Sbjct: 382 TDEAPGETILRDGRRYKSYRGMGSLGAMDQGSADRYFQGG---SRKFVPEGIEGIIAYRG 438
Query: 423 TVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
T EV+YQ VGGLK+ MGY GA ++ L++ +FV IT A L ESHPH + IT EAPNY
Sbjct: 439 TAGEVIYQFVGGLKSSMGYCGAPDLTTLRDTAQFVRITGASLVESHPHGVTITKEAPNY 497
>pir||S66039 IMP dehydrogenase - Bacillus subtilis >gi|7427684|pir||DEBSMP IMP
dehydrogenase (EC 1.1.1.205) - Bacillus subtilis
>gi|467399|dbj|BAA05245.1| (D26185) IMP dehydrogenase
[Bacillus subtilis] >gi|2632276|emb|CAB11785.1| (Z99104)
inositol-monophosphate dehydrogenase [Bacillus subtilis]
Length = 488
Score = 466 bits (1187), Expect = e-130
Identities = 244/492 (49%), Positives = 350/492 (70%), Gaps = 20/492 (4%)
Query: 3 KFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWE 62
KF+K+ G TFDDVLL+P +EV P+DVD+S ++T +KLNIP++SA MDTVTE
Sbjct: 5 KFSKE------GLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNIPVISAGMDTVTESA 58
Query: 63 MAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKH 122
MA+AMAR+GGLG+IH+NMSIE+Q EQV +VK++ER ++ + ++P+ V A LM K+
Sbjct: 59 MAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFLTPDHQVFDAEHLMGKY 118
Query: 123 DIDGLPVVENE---KVVGIISKKDIA--AREGKLVKELMTKD-VITVPENIEVEEALKIM 176
I G+P+V NE K+VGII+ +D+ + + ++MTK+ ++T ++EA KI+
Sbjct: 119 RISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKEELVTASVGTTLDEAEKIL 178
Query: 177 IENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD--IRRAI 234
+++I++LP+VD + +L GLIT+ D+ ++ N+ +D +G L+V AAV + R
Sbjct: 179 QKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIHGRLIVGAAVGVTGDTMTRVK 238
Query: 235 ELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAV 291
+L A DVIV+DTAH H+ + + ++R+ + + I GN+A +A L AD V
Sbjct: 239 KLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNIIAGNVATAEATRALIEAGADVV 298
Query: 292 KVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGA 351
KVGIGPGSICTTR+VAGVGVPQITAI A A+++G +IADGGIK+SGDI KA+AAG
Sbjct: 299 KVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKTIIADGGIKFSGDITKALAAGG 358
Query: 352 DAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVP 411
AVMLG+LLAGT E+PG+ I GR++K YRGMGS+ AM KG +RY+Q + +KFVP
Sbjct: 359 HAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKGSKDRYFQ---EENKKFVP 415
Query: 412 EGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHD 471
EG+EG PY+G V E +YQLVGGL++GMGY G+++++ L+E+ +F+ +T AGLRESHPHD
Sbjct: 416 EGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKDLRALREEAQFIRMTGAGLRESHPHD 475
Query: 472 IIITNEAPNYPL 483
+ IT E+PNY +
Sbjct: 476 VQITKESPNYTI 487
>sp|P56088|IMDH_HELPY INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|7427685|pir||E64623 IMP dehydrogenase (EC
1.1.1.205) - Helicobacter pylori (strain 26695)
>gi|2313963|gb|AAD07879.1| (AE000594)
inosine-5'-monophosphate dehydrogenase (guaB)
[Helicobacter pylori 26695]
Length = 481
Score = 461 bits (1174), Expect = e-129
Identities = 231/475 (48%), Positives = 342/475 (71%), Gaps = 7/475 (1%)
Query: 13 RGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGG 72
R TF+DVL++P+ + V PKDV + +++T N++LNIP +SAAMDTVTE + A+AMAR GG
Sbjct: 6 RALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIRLNIPFISAAMDTVTEHKTAIAMARLGG 65
Query: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN 132
+G++H+NM I+ QV+++ +VKK+E ++ D I I T+ A + + + I G+PVV++
Sbjct: 66 IGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDD 125
Query: 133 EKV-VGIISKKDIAARE--GKLVKELMTK-DVITVPENIEVEEALKIMIENRIDRLPVVD 188
+ + +GI++ +D+ K V ++MTK ++T I ++EA +M +++I++LP+VD
Sbjct: 126 KGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLDEASDLMHKHKIEKLPIVD 185
Query: 189 KEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDT 248
K+ L GLIT+ D+ R +Y A +D+ G L V AA+ + RA L +AG D +V+D+
Sbjct: 186 KDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDALVLDS 245
Query: 249 AHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTTRIV 306
AH H+ + ++E+++ + D IVGN+ +A DL A DA+KVGIGPGSICTTRIV
Sbjct: 246 AHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAIKVGIGPGSICTTRIV 305
Query: 307 AGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEA 366
AGVG+PQ++AI + A ++ + VIADGGI+YSGD+ KA+A GA +VM+G+LLAGT+E+
Sbjct: 306 AGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEES 365
Query: 367 PGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSE 426
PG +I GR+YK YRGMGS+GAM KG ++RY+Q G + + K VPEG+EG VPYRG VS+
Sbjct: 366 PGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEG-VASEKLVPEGIEGRVPYRGKVSD 424
Query: 427 VLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
+++QLVGG+++ MGY GA+NI EL + EFV ITSAGL+ESH H + IT EAPNY
Sbjct: 425 MIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNY 479
>pir||H71890 IMP dehydrogenase (EC 1.1.1.205) - Helicobacter pylori (strain
J99) >gi|4155333|gb|AAD06347.1| (AE001507)
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE [Helicobacter
pylori J99]
Length = 481
Score = 460 bits (1171), Expect = e-128
Identities = 232/475 (48%), Positives = 341/475 (70%), Gaps = 7/475 (1%)
Query: 13 RGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGG 72
R TF+DVL++P+ + V PKDV + +++T N+ LNIP +SAAMDTVTE + A+AMAR GG
Sbjct: 6 RALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIGLNIPFISAAMDTVTEHKTAIAMARLGG 65
Query: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN 132
+G++H+NM I+ QV+++ +VKK+E ++ D I I T+ A + + + I G+PVV++
Sbjct: 66 IGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDD 125
Query: 133 EKV-VGIISKKDIAARE--GKLVKELMTK-DVITVPENIEVEEALKIMIENRIDRLPVVD 188
+ + +GI++ +D+ K V ++MTK ++T I ++EA +M +++I++LP+VD
Sbjct: 126 KGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLDEASDLMHKHKIEKLPIVD 185
Query: 189 KEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDT 248
K+ L GLIT+ D+ R +Y A +D+ G L V AA+ + RA L +AG D +V+D+
Sbjct: 186 KDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDALVLDS 245
Query: 249 AHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTTRIV 306
AH H+ + ++E+++ + D IVGN+ +A DL A DAVKVGIGPGSICTTRIV
Sbjct: 246 AHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIV 305
Query: 307 AGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEA 366
AGVG+PQ++AI + A ++ + VIADGGI+YSGD+ KA+A GA +VM+G+LLAGT+E+
Sbjct: 306 AGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEES 365
Query: 367 PGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSE 426
PG +I GR+YK YRGMGS+GAM KG ++RY+Q G + + K VPEG+EG VPYRG VS+
Sbjct: 366 PGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEG-VASEKLVPEGIEGRVPYRGKVSD 424
Query: 427 VLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
+++QLVGG+++ MGY GA+NI EL + EFV ITSAGL+ESH H + IT EAPNY
Sbjct: 425 MIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNY 479
>sp|O50316|IMDH_CHLVI INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|7469229|pir||T17196 IMP dehydrogenase (EC
1.1.1.205) [similarity] - Chlorobium vibrioforme
>gi|2661858|emb|CAB06303.1| (Z83933) inosine
monophosphate dehydrogenase [Chlorobium vibrioforme]
Length = 521
Score = 458 bits (1167), Expect = e-128
Identities = 238/481 (49%), Positives = 339/481 (69%), Gaps = 16/481 (3%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLL+P + V PK+ V +++T N+++N+P++SAAMDTVTE E+A+A+AR GG+G+
Sbjct: 38 TFDDVLLVPAYSNVLPKETVVKSRVTRNIEVNLPLVSAAMDTVTEAELAIALARAGGIGI 97
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEK- 134
IH+N+SI+ Q V +VK+ E I+ + IT+ + T+ A+ LM +H I G+PVVE
Sbjct: 98 IHKNLSIDVQARHVAKVKRFESGIIRNPITLFEDATIQEAIDLMLRHSISGIPVVERPTP 157
Query: 135 -----VVGIISKKDI--AAREGKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
+ GI++ +D+ + + ++T D+IT E+I++ A +I+++N+I++L V+
Sbjct: 158 EGCLLLKGIVTNRDLRMTTSSNEKITTIITTDLITAQEDIDLLAAEEILMQNKIEKLLVI 217
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVS--PFDIRRAIELDRAGADVIV 245
D+EG L GLIT D+ RK+ +A +D +G L V AAV I R L AG DV+
Sbjct: 218 DEEGYLKGLITFKDIQKRKQCPDACKDMHGRLRVGAAVGIRSNTITRVDALVEAGVDVVA 277
Query: 246 VDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICT 302
VDTAH H+ + + +++K + + I GN+A P+AV DL A DAVKVGIGPGSICT
Sbjct: 278 VDTAHGHSQAVLDMVATIKEKYPELEVIAGNVATPEAVRDLVKAGADAVKVGIGPGSICT 337
Query: 303 TRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAG 362
TR+VAGVG+PQ+TAI A A + +IADGGIKYSGDI KA+AAGAD VM+G++ AG
Sbjct: 338 TRVVAGVGMPQLTAIMNCAKEAAKTDTPIIADGGIKYSGDISKALAAGADTVMMGSIFAG 397
Query: 363 TKEAPGKEVIINGRKYKQYRGMGSLGAMM--KGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
T E+PG+ ++ GR++K YRGMGSLGAM +G ++RY+Q +T+K+VPEG+EG +P
Sbjct: 398 TDESPGETILYEGRRFKAYRGMGSLGAMSEPEGSSDRYFQDASAETKKYVPEGIEGRIPQ 457
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
R + EV+YQL+GGLK+ MGY G +NI+ELK+ FV ITSAGLRESHPHD++IT EAPN
Sbjct: 458 R-PLDEVVYQLIGGLKSSMGYCGVKNIEELKKNTRFVRITSAGLRESHPHDVMITREAPN 516
Query: 481 Y 481
Y
Sbjct: 517 Y 517
>pdb|1ZFJ|A Chain A, Inosine Monophosphate Dehydrogenase (Impdh; Ec 1.1.1.205)
From Streptococcus Pyogenes
Length = 491
Score = 456 bits (1161), Expect = e-127
Identities = 246/490 (50%), Positives = 332/490 (67%), Gaps = 17/490 (3%)
Query: 3 KFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWE 62
KF KK GYTFDDVLLIP + V P +VD+ T++ N+ LNIPI++AA DTVT +
Sbjct: 6 KFLKK------GYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAXDTVTGSK 59
Query: 63 MAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKH 122
A+A+AR GGLGVIH+N SI EQ E+V++VK++E ++ D ++PE V A L +++
Sbjct: 60 XAIAIARAGGLGVIHKNXSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELXQRY 119
Query: 123 DIDGLPVVE---NEKVVGIISKKD---IAAREGKLVKELMTKDVITVPENIEVEEALKIM 176
I G+P+VE N K+VGII+ +D I+ + + ++ ++T ++E A +I+
Sbjct: 120 RISGVPIVETLANRKLVGIITNRDXRFISDYNAPISEHXTSEHLVTAAVGTDLETAERIL 179
Query: 177 IENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD--IRRAI 234
E+RI++LP+VD GRL GLIT+ D+ ++ +A +DE G LLVAAAV RA
Sbjct: 180 HEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAE 239
Query: 235 ELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAV 291
L AGAD IV+DTAH H+ ++ + E+R + I GNIA + L A D V
Sbjct: 240 ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVV 299
Query: 292 KVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGA 351
KVGIGPGSICTTR+VAGVGVPQ+TAI A A+EYG +IADGGIKYSGDIVKA+AAG
Sbjct: 300 KVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG 359
Query: 352 DAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVP 411
+AV LG+ AGT EAPG+ I GRKYK YRG GS+ A KG ++RY+QG + K VP
Sbjct: 360 NAVXLGSXFAGTDEAPGETEIYQGRKYKTYRGXGSIAAXKKGSSDRYFQGSVNEANKLVP 419
Query: 412 EGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHD 471
EG+EG V Y+G S++++Q +GG+++G GYVGA +I+EL E +FV + AGL ESHPHD
Sbjct: 420 EGIEGRVAYKGAASDIVFQXLGGIRSGXGYVGAGDIQELHENAQFVEXSGAGLIESHPHD 479
Query: 472 IIITNEAPNY 481
+ ITNEAPNY
Sbjct: 480 VQITNEAPNY 489
>sp|P21879|IMDH_BACSU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) (SUPEROXIDE-INDUCIBLE PROTEIN 12) (SOI12)
>gi|39959|emb|CAA39204.1| (X55669) IMP dehydrogenase
[Bacillus subtilis]
Length = 513
Score = 455 bits (1157), Expect = e-127
Identities = 240/484 (49%), Positives = 343/484 (70%), Gaps = 20/484 (4%)
Query: 3 KFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWE 62
KF+K+ G TFDDVLL+P +EV P DVD+S ++T +KLNIP++SA MDTVTE
Sbjct: 5 KFSKE------GLTFDDVLLVPAKSEVLPHDVDLSVELTKTLKLNIPVISAGMDTVTESA 58
Query: 63 MAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKH 122
MA+AMAR+GGLG+IH+NMSIE+Q EQV +VK++ER ++ + ++P+ V A LM K+
Sbjct: 59 MAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFLTPDHQVFDAEHLMGKY 118
Query: 123 DIDGLPVVENE---KVVGIISKKDIA--AREGKLVKELMTKD-VITVPENIEVEEALKIM 176
I G+P+V NE K+VGII+ +D+ + + ++MTK+ ++T ++EA KI+
Sbjct: 119 RISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKEELVTASVGTTLDEAEKIL 178
Query: 177 IENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD--IRRAI 234
+++I++LP+VD + +L GLIT+ D+ ++ N+ +D +G L+V AAV + R
Sbjct: 179 QKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIHGRLIVGAAVGVTGDTMTRVK 238
Query: 235 ELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAV 291
+L A DVIV+DTAH H+ + + ++R+ + + I GN+A +A L AD V
Sbjct: 239 KLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNIIAGNVATAEATRALIEAGADVV 298
Query: 292 KVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGA 351
KVGIGPGSICTTR+VAGVGVPQITAI A A+++G +IADGGIK+SGDI KA+AAG
Sbjct: 299 KVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKTIIADGGIKFSGDITKALAAGG 358
Query: 352 DAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVP 411
AVMLG+LLAGT E+PG+ I GR++K YRGMGS+ AM KG +RY+Q + +KFVP
Sbjct: 359 HAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKGSKDRYFQ---EENKKFVP 415
Query: 412 EGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHD 471
EG+EG PY+G V E +YQLVGGL++GMGY G+++++ L+E+ +F+ +T AGLRESHPHD
Sbjct: 416 EGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKDLRALREEAQFIRMTGAGLRESHPHD 475
Query: 472 IIIT 475
+ IT
Sbjct: 476 VQIT 479
>emb|CAB82009.1| (AL161755) inosine 5' monophosphate dehydrogenase [Streptomyces
coelicolor A3(2)]
Length = 501
Score = 453 bits (1153), Expect = e-126
Identities = 245/489 (50%), Positives = 336/489 (68%), Gaps = 14/489 (2%)
Query: 11 AIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMARE 70
A G T+DDVLL+P A+ V P VD S++I+ NV++NIP+LSAAMD VTE MA++MAR+
Sbjct: 13 ATLGLTYDDVLLLPGASAVLPNAVDTSSRISRNVRVNIPLLSAAMDKVTESRMAISMARQ 72
Query: 71 GGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV 130
GG+GV+HRN+SIE+Q QV VK++E +V + ITI P+ T+ A L K I G+PV
Sbjct: 73 GGVGVLHRNLSIEDQANQVDLVKRSESGMVANPITIHPDATLGEADALCAKFRISGVPVT 132
Query: 131 ENE-KVVGIISKKDIAAR--EGKLVKELMTK-DVITVPENIEVEEALKIMIENRIDRLPV 186
+ K++GI++ +D+A + V+E+MT ++T I +A++++ ++I++LP+
Sbjct: 133 DGAGKLLGIVTNRDMAFETDRSRQVREVMTPMPLVTGQVGISGVDAMELLRRHKIEKLPL 192
Query: 187 VDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV--SPFDIRRAIELDRAGADVI 244
VD +G L GLIT+ D V ++Y +A +D G LLV AAV SP + RA L AG D +
Sbjct: 193 VDGDGILKGLITVKDFVKAEQYPHAAKDAKGRLLVGAAVGASPEALDRAQALAEAGVDFL 252
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICT 302
VVDT+H HN A+ M +++ V D + GN+A L A D +KVG+GPGSICT
Sbjct: 253 VVDTSHGHNSNALSWMSKIKSSVGIDVVGGNVATRDGAQALIDAGVDGIKVGVGPGSICT 312
Query: 303 TRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAG 362
TR+VAG+GVPQ+TAI + A+ G+ +I DGG++YSGDI KA+AAGAD VMLG+LLAG
Sbjct: 313 TRVVAGIGVPQVTAIYEASLAARAAGVPLIGDGGLQYSGDIGKALAAGADTVMLGSLLAG 372
Query: 363 TKEAPGKEVIINGRKYKQYRGMGSLGAMMKGG------AERYYQGGYMKTRKFVPEGVEG 416
+E+PG+ ING+++K YRGMGSLGAM G +RY+Q K VPEG+EG
Sbjct: 373 CEESPGELQFINGKQFKSYRGMGSLGAMQSRGQGRSYSKDRYFQAEVASDDKLVPEGIEG 432
Query: 417 VVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITN 476
VPYRG ++ VL+QLVGGL+ MGYVGA I+E++ KG FV ITSAGL+ESHPHDI +T
Sbjct: 433 QVPYRGPLANVLHQLVGGLRQTMGYVGAATIEEMESKGRFVRITSAGLKESHPHDIQMTV 492
Query: 477 EAPNYPLEK 485
EAPNY K
Sbjct: 493 EAPNYSRSK 501
>pir||JC7305 IMP dehydrogenase (EC 1.1.1.205) - Bacillus cereus
>gi|6561887|dbj|BAA88235.1| (AB035643) IMP dehydrogenase
[Bacillus cereus]
Length = 509
Score = 453 bits (1152), Expect = e-126
Identities = 241/477 (50%), Positives = 341/477 (70%), Gaps = 14/477 (2%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G TFDDVLL+P +++ P++V V T ++ +++LNIP++SA MDTVTE +MA+AMAR+GGL
Sbjct: 10 GLTFDDVLLVPARSDILPREVSVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGL 69
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN- 132
G+IH+NMSIE+Q EQV +VK++E ++ D ++PE V A LM K+ I G+PVV N
Sbjct: 70 GIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPVVNNL 129
Query: 133 --EKVVGIISKKDIAAREGKLVK--ELMTKD-VITVPENIEVEEALKIMIENRIDRLPVV 187
K+VGII+ +D+ + +K ++MTK+ +IT P +EEA KI+ + +I++LP+V
Sbjct: 130 DERKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLEEAEKILQKYKIEKLPLV 189
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVS-PFDIRRAIE-LDRAGADVIV 245
D G L GLIT+ D+ ++ N+ +D+ G LLV AAV D I+ L +A D IV
Sbjct: 190 DNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAYLRIDALVKASVDAIV 249
Query: 246 VDTAHAHNLKAIKAMKEMRQKVDA-DFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICT 302
+DTAH H+ I +KE+R K + + I GN+A +A L A + VKVGIGPGSICT
Sbjct: 250 LDTAHGHSKGVIDKVKEVRAKYPSLNIIAGNVATAEATKALIEAGENVVKVGIGPGSICT 309
Query: 303 TRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAG 362
TR+VAGVGVPQ+TA+ A A+++G+ VIADGGIKYSGD+VKA+AAGA VMLG++ AG
Sbjct: 310 TRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAG 369
Query: 363 TKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRG 422
E+PG+ I GR++K YRGMGS+GAM KG +RY+Q G +K VPEG+EG VPY+G
Sbjct: 370 VAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEG---NKKLVPEGIEGRVPYKG 426
Query: 423 TVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAP 479
+++ ++QLVGGL+AGMGY GA++++ L+E +F+ ++ AGLRESHPH + IT EAP
Sbjct: 427 PLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFIRMSGAGLRESHPHHVQITKEAP 483
>dbj|BAA89464.1| (AB036795) IMPDH [Bacillus cereus]
Length = 509
Score = 451 bits (1149), Expect = e-126
Identities = 241/477 (50%), Positives = 340/477 (70%), Gaps = 14/477 (2%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G TFDDVLL+P ++V P++V V T ++ +++LNIP++SA MDTVTE +MA+AMAR+GGL
Sbjct: 10 GLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGL 69
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN- 132
G+IH+NMSIE+Q EQV +VK++E ++ D ++PE V A LM K+ I G+PVV N
Sbjct: 70 GIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPVVNNL 129
Query: 133 --EKVVGIISKKDIAAREGKLVK--ELMTKD-VITVPENIEVEEALKIMIENRIDRLPVV 187
K+VGII+ +D+ + +K ++MTK+ +IT P ++EA KI+ + +I++LP+V
Sbjct: 130 DERKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLDEAEKILQKYKIEKLPLV 189
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV--SPFDIRRAIELDRAGADVIV 245
D G L GLIT+ D+ ++ N+ +D+ G LLV AAV + + R L +A D IV
Sbjct: 190 DNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDALVKASVDAIV 249
Query: 246 VDTAHAHNLKAIKAMKEMRQKVDA-DFIVGNIANPKAVDDLTFADA--VKVGIGPGSICT 302
+DTAH H+ I +KE+R K + + I GN+A +A L A A VKVGIGPGSICT
Sbjct: 250 LDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATGALIEAGANVVKVGIGPGSICT 309
Query: 303 TRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAG 362
TR+VAGVGVPQ+TA+ A A+++G+ VIADGGIKYSGD+VKA+AAGA VMLG++ AG
Sbjct: 310 TRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAG 369
Query: 363 TKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRG 422
E+PG+ I GR++K YRGMGS+GAM KG +RY+Q G +K VPEG+EG VPY+G
Sbjct: 370 VAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEG---NKKLVPEGIEGRVPYKG 426
Query: 423 TVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAP 479
+++ ++QLVGGL+AGMGY GA++++ L+E +FV ++ AGL ESHPH + IT EAP
Sbjct: 427 PLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFVRMSGAGLLESHPHHVQITKEAP 483
>pir||H81109 IMP dehydrogenase (EC 1.1.1.205) NMB1201 [similarity] - Neisseria
meningitidis (group B strain MD58)
>gi|7226438|gb|AAF41583.1| (AE002468) IMP dehydrogenase
[Neisseria meningitidis MC58]
Length = 487
Score = 448 bits (1139), Expect = e-125
Identities = 240/480 (50%), Positives = 329/480 (68%), Gaps = 11/480 (2%)
Query: 13 RGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGG 72
+ YTFDDVLL+P + V P+DV + T++T + LN+P+LSAAMDTVTE +A++MA+EGG
Sbjct: 6 KAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMDTVTEARLAISMAQEGG 65
Query: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFL--MEKHDIDGLPVV 130
+G+IH+NM E Q V +VK+ E +V+D +T++P + L + K + GLPVV
Sbjct: 66 IGIIHKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKMSGLPVV 125
Query: 131 ENEKVVGIISKKDIAA--REGKLVKELMT--KDVITVPENIEVEEALKIMIENRIDRLPV 186
EN KVVGI++ +D+ R V +MT + ++TVPE ++EA ++M ++++R+ V
Sbjct: 126 ENGKVVGIVTNRDLRFENRVDLPVSAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLV 185
Query: 187 VDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDI--RRAIELDRAGADVI 244
++++ L GLIT+ D++ ++ NA +D G L V AAV R L AG DVI
Sbjct: 186 LNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGDTEERVKALVEAGVDVI 245
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSIC 301
VVDTAH H+ I ++ +++ I GNIA KA DL A DAVKVGIGPGSIC
Sbjct: 246 VVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSIC 305
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
TTRIVAGVGVPQ+TAI VA+ + G+ +IADGGI++SGDI KA+AAGA +VMLG + A
Sbjct: 306 TTRIVAGVGVPQLTAIHNVAEALKGTGVPLIADGGIRFSGDIAKALAAGAYSVMLGGMFA 365
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYR 421
GT+EAPG+ + GR YK YRGMGSLGAM +G A+RY+Q T K+VPEG+EG VPY+
Sbjct: 366 GTEEAPGEIELYQGRSYKSYRGMGSLGAMSQGSADRYFQDKTDSTDKYVPEGIEGRVPYK 425
Query: 422 GTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
G + +++QL GGL++ MGY+G NI E+ EK EFV ITSAG+ ESH HD+ IT EAPNY
Sbjct: 426 GPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMSESHVHDVQITKEAPNY 485
>pir||F81906 IMP dehydrogenase (EC 1.1.1.205) NMA1372 [similarity] - Neisseria
meningitidis (group A strain Z2491)
>gi|7380040|emb|CAB84618.1| (AL162755) putative
inosine-5'-monophosphate dehydrogenase [Neisseria
meningitidis Z2491]
Length = 487
Score = 445 bits (1133), Expect = e-124
Identities = 238/480 (49%), Positives = 328/480 (67%), Gaps = 11/480 (2%)
Query: 13 RGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGG 72
+ YTFDDVLL+P + V P+DV + T++T + LN+P+LSAAMDTVTE +A++MA+EGG
Sbjct: 6 KAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMDTVTEARLAISMAQEGG 65
Query: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFL--MEKHDIDGLPVV 130
+G+IH+NM E Q + +VK+ E +V+D +T++P + L + K + GLPVV
Sbjct: 66 IGIIHKNMPPEMQARAISKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKMSGLPVV 125
Query: 131 ENEKVVGIISKKDIAA--REGKLVKELMT--KDVITVPENIEVEEALKIMIENRIDRLPV 186
EN KVVGI++ +D+ R V +MT + ++TVPE ++EA ++M ++++R+ V
Sbjct: 126 ENGKVVGIVTNRDLRFENRVDLPVSAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLV 185
Query: 187 VDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDI--RRAIELDRAGADVI 244
++++ L GLIT+ D++ ++ NA +D G L V AAV R L AG DVI
Sbjct: 186 LNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGDTEERVKALVEAGVDVI 245
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSIC 301
VVDTAH H+ I ++ +++ I GNIA KA DL A DAVKVGIGPGSIC
Sbjct: 246 VVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSIC 305
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
TTRIVAGVGVPQ+TAI VA+ + G+ +IADGGI++SGDI KA+AAGA +VMLG + A
Sbjct: 306 TTRIVAGVGVPQLTAIHNVAEALKGTGVPLIADGGIRFSGDIAKALAAGAYSVMLGGMFA 365
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYR 421
GT+EAPG+ + GR YK YRGMGSLGAM +G A+RY+Q K+VPEG+EG VPY+
Sbjct: 366 GTEEAPGEIELYQGRSYKSYRGMGSLGAMSQGSADRYFQDKTDSADKYVPEGIEGRVPYK 425
Query: 422 GTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
G + +++QL GGL++ MGY+G NI E+ EK EFV ITSAG+ ESH HD+ IT EAPNY
Sbjct: 426 GPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMSESHVHDVQITKEAPNY 485
>dbj|BAA89452.1| (AB003154) IMP dehydrogenase [Corynebacterium ammoniagenes]
Length = 506
Score = 443 bits (1126), Expect = e-123
Identities = 237/490 (48%), Positives = 330/490 (66%), Gaps = 20/490 (4%)
Query: 11 AIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMARE 70
A+ G TFDDVLL+P + V P +VD S Q T N +L IP+ SAAMDTVTE MA+AMAR+
Sbjct: 17 ALHGLTFDDVLLLPAESNVVPSEVDTSAQFTRNTRLGIPLASAAMDTVTEARMAIAMARQ 76
Query: 71 GGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV 130
GG+GV+HRN+S +EQ EQV+ VK++E +V D +T +P+ T+ L + I GLPVV
Sbjct: 77 GGIGVLHRNLSSQEQAEQVEIVKRSESGMVTDPVTANPDMTIQEVDDLCARFRISGLPVV 136
Query: 131 -ENEKVVGIISKKDIAARE--GKLVKELMTK-DVITVPENIEVEEALKIMIENRIDRLPV 186
E+ ++GI + +D+ + V ++MT ++ E + EEAL ++ N++++LP+
Sbjct: 137 NEDGTLLGICTNRDMRFERDYSRKVSDIMTAMPLVVAKEGVSKEEALDLLSTNKVEKLPI 196
Query: 187 VDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD--IRRAIELDRAGADVI 244
VDK +L+GLIT+ D V +++ N+ +D +G LLVAA + + RA L AG DV+
Sbjct: 197 VDKNNKLVGLITVKDFVKTEQFPNSSKDASGRLLVAAGIGTGEESYERAGLLVDAGVDVL 256
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVDA--DFIVGNIANPKAVDDL--TFADAVKVGIGPGSI 300
+VD+AHAHN + ++ + ++ + D + GN+A A + ADA+KVGIGPGSI
Sbjct: 257 IVDSAHAHNNRVLEMVSRVKNDFGSKIDVVGGNLATRSAAKAMIEAGADAIKVGIGPGSI 316
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR+VAGVG PQITAI A A G+ +IADGG++YSGD+ KA+AAGAD+VMLG++
Sbjct: 317 CTTRVVAGVGAPQITAIMEAATVASAAGVPLIADGGMQYSGDVAKALAAGADSVMLGSMF 376
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGG---------AERYYQGGYMKTRKFVP 411
AGT EAPG VI+ G++YK+YRGMGS+GAM G +RY+Q K VP
Sbjct: 377 AGTLEAPGDIVIVGGKQYKRYRGMGSMGAMQGRGLSGEKRSYSKDRYFQADVRSEDKLVP 436
Query: 412 EGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHD 471
EGVEG VPYRG + ++ +Q+VGGL+A MGY G+ I+ELK K +FV IT+AGL ESHPH
Sbjct: 437 EGVEGKVPYRGEIGQITHQIVGGLRAAMGYTGSATIEELKTK-QFVRITTAGLAESHPHH 495
Query: 472 IIITNEAPNY 481
+ T EAPNY
Sbjct: 496 LQQTVEAPNY 505
>sp|Q50715|IMDH_MYCTU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|7427687|pir||H70736 IMP dehydrogenase (EC
1.1.1.205) guaB2 - Mycobacterium tuberculosis (strain
H37RV) >gi|1449376|emb|CAB01012.1| (Z77165) guaB2
[Mycobacterium tuberculosis]
Length = 529
Score = 442 bits (1124), Expect = e-123
Identities = 242/487 (49%), Positives = 331/487 (67%), Gaps = 17/487 (3%)
Query: 11 AIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMARE 70
A+ G TFDDVLL+P A++V P D S+Q+T ++L +P++S+AMDTVTE MA+AMAR
Sbjct: 41 AMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARA 100
Query: 71 GGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV 130
GG+GV+HRN+ + EQ QV+ VK++E +V D +T P+ T+ L + I GLPVV
Sbjct: 101 GGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVV 160
Query: 131 ENE-KVVGIISKKDIAAR--EGKLVKELMTK-DVITVPENIEVEEALKIMIENRIDRLPV 186
+++ +VGII+ +D+ + K V E+MTK +IT E + AL ++ N+I++LPV
Sbjct: 161 DDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPV 220
Query: 187 VDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIR--RAIELDRAGADVI 244
VD GRL GLIT+ D V +++ A +D +G LLV AAV RA+ L AG DV+
Sbjct: 221 VDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVL 280
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVD--ADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSI 300
VVDTAHAHN + + +++ +V + + GN+A A L A DAVKVG+GPGSI
Sbjct: 281 VVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSI 340
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR+VAGVG PQITAI + G+ VIADGG++YSGDI KA+AAGA MLG+LL
Sbjct: 341 CTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLL 400
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMM-KGGA-----ERYYQGGYMKTRKFVPEGV 414
AGT EAPG+ + +NG++YK YRGMGSLGAM +GGA +RY+ + K VPEG+
Sbjct: 401 AGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGI 460
Query: 415 EGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIII 474
EG VP+RG +S V++QL GGL+A MGY G+ I E+ ++ +FV IT AGL+ESHPHD+ +
Sbjct: 461 EGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTI-EVLQQAQFVRITPAGLKESHPHDVAM 519
Query: 475 TNEAPNY 481
T EAPNY
Sbjct: 520 TVEAPNY 526
>pir||H83173 inosine-5'-monophosphate dehydrogenase PA3770 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9949941|gb|AAG07157.1|AE004796_2 (AE004796)
inosine-5'-monophosphate dehydrogenase [Pseudomonas
aeruginosa]
Length = 489
Score = 437 bits (1112), Expect = e-121
Identities = 237/477 (49%), Positives = 325/477 (67%), Gaps = 11/477 (2%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLLIP +EV PKDV + T++T ++LNIP++SAAMDTVTE +A+AMA+EGG+G+
Sbjct: 10 TFDDVLLIPGYSEVLPKDVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGI 69
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKV 135
IH+NM IE+Q +V++VKK E IV D +T++P + L + ++ G PVVE ++
Sbjct: 70 IHKNMGIEQQAAEVRKVKKHETAIVRDPVTVTPSTKIIELLQMAREYGFSGFPVVEQGEL 129
Query: 136 VGIISKKDIAARE--GKLVKELMT-KD-VITVPENIEVEEALKIMIENRIDRLPVVDKEG 191
VGI++ +D+ + G V +MT KD ++T E +EE + ENRI+++ VVD+
Sbjct: 130 VGIVTGRDLRVKPNAGDTVAAIMTPKDKLVTAREGTPLEEMKAKLYENRIEKMLVVDENF 189
Query: 192 RLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDI--RRAIELDRAGADVIVVDTA 249
L GL+T D+ K Y A +DE G L V AAV R L AG DV+VVDTA
Sbjct: 190 YLRGLVTFRDIEKAKTYPLASKDEQGRLRVGAAVGTGADTGERVAALVAAGVDVVVVDTA 249
Query: 250 HAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTTRIV 306
H H+ I+ ++ ++Q D I GNIA +A L A DAVKVGIGPGSICTTRIV
Sbjct: 250 HGHSKGVIERVRWVKQTFPDVQVIGGNIATAEAAKALAEAGADAVKVGIGPGSICTTRIV 309
Query: 307 AGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEA 366
AGVGVPQI+AIA VA + G+ +IADGGI++SGD+ KA+ AGA VM+G++ AGT+EA
Sbjct: 310 AGVGVPQISAIANVAAALEGTGVPLIADGGIRFSGDLAKAMVAGAYCVMMGSMFAGTEEA 369
Query: 367 PGKEVIINGRKYKQYRGMGSLGAM--MKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTV 424
PG+ + GR YK YRGMGSLGAM +G ++RY+Q K VPEG+EG VPY+G +
Sbjct: 370 PGEIELFQGRSYKSYRGMGSLGAMSGSQGSSDRYFQDASAGAEKLVPEGIEGRVPYKGAL 429
Query: 425 SEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
S +++QL+GGL+A MGY G+ +I++++ + +FV IT AG+ ESH HD+ IT EAPNY
Sbjct: 430 SAIVHQLMGGLRAAMGYTGSADIQQMRTQPQFVRITGAGMAESHVHDVQITKEAPNY 486
>sp|Q49729|IMDH_MYCLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|2145868|pir||S72823 IMP dehydrogenase (EC
1.1.1.205) guaB2 - Mycobacterium leprae
>gi|466944|gb|AAC43232.1| (U00015) guaB2; B1620_C3_238
[Mycobacterium leprae]
Length = 529
Score = 434 bits (1105), Expect = e-121
Identities = 238/487 (48%), Positives = 328/487 (66%), Gaps = 17/487 (3%)
Query: 11 AIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMARE 70
A+ G TFDDVLL+P A++V P D+S+Q+T ++L +P++S+AMDTVTE MA+AMAR
Sbjct: 41 AMLGLTFDDVLLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARA 100
Query: 71 GGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV 130
GG+GV+HRN+ + EQ QV+ VK++E +V D +T P+ T+ L + I GLPVV
Sbjct: 101 GGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVV 160
Query: 131 ENE-KVVGIISKKDIAAR--EGKLVKELMTKD-VITVPENIEVEEALKIMIENRIDRLPV 186
++ + GII+ +D+ + K V E+MTK +IT E + + AL ++ N+I++LPV
Sbjct: 161 DDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPV 220
Query: 187 VDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIR--RAIELDRAGADVI 244
VD GRL GLIT+ D V +++ A +D +G LLV AAV RA+ L AG DV+
Sbjct: 221 VDGHGRLTGLITVKDFVKTEQHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVL 280
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVD--ADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSI 300
+VDTAHAHN + + +++ ++ I GN+A A L A DAVKVG+GPGS
Sbjct: 281 IVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGST 340
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR+VAGVG PQITAI G+ VIADGG++YSGDI KA+AAGA MLG+LL
Sbjct: 341 CTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLL 400
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMM-KGG-----AERYYQGGYMKTRKFVPEGV 414
AGT EAPG+ + +NG+++K YRGMGSLGAM +GG +RY+ + K VPEG+
Sbjct: 401 AGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGI 460
Query: 415 EGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIII 474
EG VP+RG +S V++QLVGGL+A MGY G+ I E+ ++ +FV IT AGL+ESHPHD+ +
Sbjct: 461 EGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTI-EVLQQAQFVRITPAGLKESHPHDVAM 519
Query: 475 TNEAPNY 481
T EAPNY
Sbjct: 520 TVEAPNY 526
>gb|AAF85967.1| (AF272827) GuaB [Rhizobium tropici]
Length = 498
Score = 423 bits (1075), Expect = e-117
Identities = 230/470 (48%), Positives = 324/470 (68%), Gaps = 10/470 (2%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLL P +EV P +++T+I +++LN+PILSAAMDTVTE +A+AMA+ GG+GV
Sbjct: 15 TFDDVLLQPGHSEVMPGQTNIATRIAQDIELNVPILSAAMDTVTESRLAIAMAQAGGMGV 74
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLME-KHDIDGLPVVE-NE 133
IHRN++ +Q E+V++VKK E +V + +TI P+ T+ AL L E PVVE +
Sbjct: 75 IHRNLTPVQQAEEVRQVKKFESGMVVNPVTIGPDATLAEALSLDEGPRHFRASPVVEKSH 134
Query: 134 KVVGIISKKDI--AAREGKLVKELMTKD-VITVPENIEVEEALKIMIENRIDRLPVVDKE 190
++VGI++ +D+ A+ + + ELMT++ ++TV + ++ EA +++ +RI++ VVD +
Sbjct: 135 RLVGILTNRDVRFASDPEQKIYELMTRENLVTVKDGVQQHEAKRLLHTHRIEKXLVVDAD 194
Query: 191 GRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD--IRRAIELDRAGADVIVVDT 248
R +GLIT+ D+ + +A +D G L AAA+S D RA L AG D++VVDT
Sbjct: 195 SRFVGLITVKDIEKSQLNPHASKDAQGRLRAAAAISVGDDGYERAERLIDAGVDLLVVDT 254
Query: 249 AHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDL--TFADAVKVGIGPGSICTTRI 305
AH H+ + + A+ +++ ++ I+ GN+A L ADAVKVGIGPGSICTTRI
Sbjct: 255 AHGHSQRVLDAVTRVKKLSNSVRIMAGNVATYDGTRALIDAGADAVKVGIGPGSICTTRI 314
Query: 306 VAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKE 365
VAGVGVPQ+ AI AQ+ + +IADGGIK+SGD+ KAIAAGA A M+G+LLAGT E
Sbjct: 315 VAGVGVPQLAAIMSAVQAAQDQNIPIIADGGIKFSGDLAKAIAAGASAAMIGSLLAGTDE 374
Query: 366 APGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVS 425
+PG+ + GR +K YRGMGS+GAM +G A+RY+Q T K VPEG+EG VPY+G VS
Sbjct: 375 SPGEVYLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGXVPYKGPVS 434
Query: 426 EVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIIT 475
VL+QL GGLKA MGYVG ++K+ +E+ FV I+ AGLRESH HD+ IT
Sbjct: 435 GVLHQLAGGLKAAMGYVGGADLKDFQERATFVRISGAGLRESHAHDVTIT 484
>sp|P44334|IMDH_HAEIN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|1074930|pir||H64055 IMP dehydrogenase (EC
1.1.1.205) - Haemophilus influenzae (strain Rd KW20)
>gi|1573185|gb|AAC21890.1| (U32708)
inosine-5'-monophosphate dehydrogenase (guaB)
[Haemophilus influenzae Rd]
Length = 488
Score = 420 bits (1067), Expect = e-116
Identities = 225/476 (47%), Positives = 325/476 (68%), Gaps = 11/476 (2%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLL+P + V P ++STQ+T ++LNIP+LSAAMDTVTE ++A+++A+EGG+G
Sbjct: 11 TFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAISLAQEGGIGF 70
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEK- 134
IH+NM+IE Q ++V++VKK E IV + +T+ P T+ +++K+ G PVV+ E
Sbjct: 71 IHKNMTIERQADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDGENN 130
Query: 135 VVGIISKKDIAARE--GKLVKELMTK--DVITVPENIEVEEALKIMIENRIDRLPVVDKE 190
++GII+ +D + K V ++MTK D++TV E EE L++M ++R++++ VV+
Sbjct: 131 LIGIITGRDTRFVKDLSKTVSQVMTKKEDLVTVKEGASREEILELMHQHRVEKVLVVNDS 190
Query: 191 GRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--DIRRAIELDRAGADVIVVDT 248
+L G+IT+ D ++ NA +DE G L V AAV + R L +AG DV+++D+
Sbjct: 191 FKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVKAGVDVLLIDS 250
Query: 249 AHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTTRI 305
+H H+ ++ ++E R K + + GN+A + L A AVKVGIGPGSICTTRI
Sbjct: 251 SHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRI 310
Query: 306 VAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKE 365
V GVGVPQITAIA A ++ G+ VIADGGI++SGDI KAIAAGA VM+G++ AGT+E
Sbjct: 311 VTGVGVPQITAIADAAAALKDRGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMFAGTEE 370
Query: 366 APGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVS 425
APG+ + GR +K YRGMGSLGAM KG ++RY+Q K VPEG+EG +PY+G +
Sbjct: 371 APGEIELYQGRAFKSYRGMGSLGAMAKGSSDRYFQSD-NAADKLVPEGIEGRIPYKGYLK 429
Query: 426 EVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
E+++Q +GGL++ MG G I EL+ K EFV I+ AG++ESH HD+ IT EAPNY
Sbjct: 430 EIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITKEAPNY 485
>gb|AAF68407.1|AF237921_1 (AF237921) inosine-5'-monophosphate dehydrogenase [Pasteurella
multocida]
Length = 487
Score = 419 bits (1066), Expect = e-116
Identities = 227/476 (47%), Positives = 321/476 (66%), Gaps = 11/476 (2%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLL+P + V P D+STQ+T ++LNIP+LSAAMDTVTE ++A+++A+EGG+G
Sbjct: 10 TFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTETKLAISLAQEGGIGF 69
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEK- 134
IH+NMSIE Q E+V++VKK E IV D +T+SP ++ L++K+ PVV++EK
Sbjct: 70 IHKNMSIERQAERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFASFPVVDDEKN 129
Query: 135 VVGIISKKD--IAAREGKLVKELMTKD--VITVPENIEVEEALKIMIENRIDRLPVVDKE 190
+VGII+ +D K V + MT ++TV N +E +M +R++++ VV +
Sbjct: 130 LVGIITGRDTRFVTDLNKTVADFMTPKARLVTVKRNASRDEIFGLMHTHRVEKVLVVSDD 189
Query: 191 GRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVS--PFDIRRAIELDRAGADVIVVDT 248
+L G+IT+ D ++ A +DE G L V AAV P + R L +AG DV+++D+
Sbjct: 190 FKLKGMITLKDYQKSEQKPQACKDEFGRLRVGAAVGAGPGNEERIDALVKAGVDVLLIDS 249
Query: 249 AHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTTRI 305
+H H+ ++ ++E R K D + GN+A + L A AVKVGIGPGSICTTRI
Sbjct: 250 SHGHSEGVLQRVRETRAKYPDLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRI 309
Query: 306 VAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKE 365
V GVGVPQITAIA A+ ++ G+ VIADGGI++SGDI KAIAAGA VM+G++ AGT+E
Sbjct: 310 VTGVGVPQITAIADAAEALKDRGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEE 369
Query: 366 APGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVS 425
APG+ + GR +K YRGMGSLGAM KG ++RY+Q K VPEG+EG +PY+G +
Sbjct: 370 APGEIELYQGRAFKSYRGMGSLGAMSKGSSDRYFQSD-NAADKLVPEGIEGRIPYKGFLK 428
Query: 426 EVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
E+++Q +GGL++ MG G I EL+ K +FV I+ AG++ESH HD+ IT EAPNY
Sbjct: 429 EIIHQQMGGLRSCMGLTGCATIDELRTKAQFVRISGAGIQESHVHDVTITKEAPNY 484
>pir||B82558 inosine-5'-monophosphate dehydrogenase XF2430 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107621|gb|AAF85229.1|AE004052_4 (AE004052)
inosine-5'-monophosphate dehydrogenase [Xylella
fastidiosa]
Length = 485
Score = 419 bits (1065), Expect = e-116
Identities = 230/476 (48%), Positives = 322/476 (67%), Gaps = 13/476 (2%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
T+DDV L+P + V PKDV++ T++T N++L +P+LSAAMDTVTE +A+ MA+ GG+G+
Sbjct: 10 TYDDVSLVPSHSTVLPKDVNLETRLTRNIRLKLPVLSAAMDTVTEARLAIVMAQLGGIGI 69
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKV 135
IH+N++IE+QV +V +VKK E ++ D IT+ PE ++ L L +I G+PVV+ ++
Sbjct: 70 IHKNLTIEQQVAEVTKVKKYESGVIRDPITVDPETSIRDVLALTRAKNISGVPVVDKGQL 129
Query: 136 VGIISKKDIAAREGKL---VKELMTKD--VITVPENIEVEEALKIMIENRIDRLPVVDKE 190
+G+++ +D+ E +L V+ +MTK ++TV E + +E L+++ ++RI+++ VV+
Sbjct: 130 IGLVTHRDMRF-ESELDDPVRHIMTKKEALVTVKEGADSQEVLQLLHKHRIEKILVVNDA 188
Query: 191 GRLIGLITMSDLVARKKYKNAVRDENGELLVAAA--VSPFDIRRAIELDRAGADVIVVDT 248
L GLIT+ D+ + Y NA +D LLV AA V RR L AG DVI+VDT
Sbjct: 189 FELRGLITVKDIQKKSDYPNAAKDAVTRLLVGAAVGVGGETERRVETLAAAGVDVIIVDT 248
Query: 249 AHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAVKVGIGPGSICTTRI 305
AH ++ + + +++ I GNI A L ADAVKVG+GPGSICTTR+
Sbjct: 249 AHGYSQGVLDRVAWIKRYFPQLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRM 308
Query: 306 VAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKE 365
VAGVGVPQITA+ MV+D Q+ + +IADGGI+YSGDI KA+AAGA VM+G L AGT+E
Sbjct: 309 VAGVGVPQITAVQMVSDALQD-RIPLIADGGIRYSGDIGKALAAGASTVMIGGLFAGTEE 367
Query: 366 APGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVS 425
APG + GR YK YRGMGSL AM KG +RY+Q K VPEG+EG VPYRG+VS
Sbjct: 368 APGDVELFQGRTYKSYRGMGSLAAMEKGSKDRYFQEA-SDVDKLVPEGIEGRVPYRGSVS 426
Query: 426 EVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
+++QL+GGL+A MGYVG I+E++ K +FV IT AG ESH HD+ IT E PNY
Sbjct: 427 GIVHQLMGGLRATMGYVGCATIEEMRTKPQFVKITGAGQVESHVHDVQITKEPPNY 482
>sp|P06981|IMDH_ECOLI INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|7427682|pir||DEECIP IMP dehydrogenase (EC
1.1.1.205) [validated] - Escherichia coli
>gi|1788855|gb|AAC75561.1| (AE000337) IMP dehydrogenase
[Escherichia coli K12]
Length = 488
Score = 418 bits (1062), Expect = e-116
Identities = 236/486 (48%), Positives = 316/486 (64%), Gaps = 11/486 (2%)
Query: 8 LERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAM 67
L A TFDDVLL+P + V P D+STQ+T ++LNIP+LSAAMDTVTE +A+A+
Sbjct: 2 LRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIAL 61
Query: 68 AREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGL 127
A+EGG+G IH+NMSIE Q E+V+RVKK E +V D T+ P T+ L E++ G
Sbjct: 62 AQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGY 121
Query: 128 PVV-ENEKVVGIISKKDI--AAREGKLVKELMT--KDVITVPENIEVEEALKIMIENRID 182
PVV E ++VGII+ +D+ + V MT + ++TV E E L M E R++
Sbjct: 122 PVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVE 181
Query: 183 RLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--DIRRAIELDRAG 240
+ VVD E LIG+IT+ D ++ NA +DE G L V AAV + R L AG
Sbjct: 182 KALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAG 241
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGP 297
DV+++D++H H+ ++ ++E R K D I GN+A L A AVKVGIGP
Sbjct: 242 VDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGP 301
Query: 298 GSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLG 357
GSICTTRIV GVGVPQITA+A + + G+ VIADGGI++SGDI KAIAAGA AVM+G
Sbjct: 302 GSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVG 361
Query: 358 NLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGV 417
++LAGT+E+PG+ + GR YK YRGMGSLGAM KG ++RY+Q K VPEG+EG
Sbjct: 362 SMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSD-NAADKLVPEGIEGR 420
Query: 418 VPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNE 477
V Y+G + E+++Q +GGL++ MG G I EL+ K EFV I+ AG++ESH HD+ IT E
Sbjct: 421 VAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE 480
Query: 478 APNYPL 483
+PNY L
Sbjct: 481 SPNYRL 486
>dbj|BAA16395.1| (D90880) IMP dehydrogenase (EC 1.1.1.205) [Escherichia coli]
Length = 511
Score = 418 bits (1062), Expect = e-116
Identities = 236/486 (48%), Positives = 316/486 (64%), Gaps = 11/486 (2%)
Query: 8 LERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAM 67
L A TFDDVLL+P + V P D+STQ+T ++LNIP+LSAAMDTVTE +A+A+
Sbjct: 25 LRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIAL 84
Query: 68 AREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGL 127
A+EGG+G IH+NMSIE Q E+V+RVKK E +V D T+ P T+ L E++ G
Sbjct: 85 AQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGY 144
Query: 128 PVV-ENEKVVGIISKKDI--AAREGKLVKELMT--KDVITVPENIEVEEALKIMIENRID 182
PVV E ++VGII+ +D+ + V MT + ++TV E E L M E R++
Sbjct: 145 PVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVE 204
Query: 183 RLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--DIRRAIELDRAG 240
+ VVD E LIG+IT+ D ++ NA +DE G L V AAV + R L AG
Sbjct: 205 KALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAG 264
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGP 297
DV+++D++H H+ ++ ++E R K D I GN+A L A AVKVGIGP
Sbjct: 265 VDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGP 324
Query: 298 GSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLG 357
GSICTTRIV GVGVPQITA+A + + G+ VIADGGI++SGDI KAIAAGA AVM+G
Sbjct: 325 GSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVG 384
Query: 358 NLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGV 417
++LAGT+E+PG+ + GR YK YRGMGSLGAM KG ++RY+Q K VPEG+EG
Sbjct: 385 SMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSD-NAADKLVPEGIEGR 443
Query: 418 VPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNE 477
V Y+G + E+++Q +GGL++ MG G I EL+ K EFV I+ AG++ESH HD+ IT E
Sbjct: 444 VAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE 503
Query: 478 APNYPL 483
+PNY L
Sbjct: 504 SPNYRL 509
>sp|P31002|IMDH_ACICA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|95325|pir||S23226 IMP dehydrogenase (EC
1.1.1.205) - Acinetobacter calcoaceticus
>gi|38720|emb|CAA47328.1| (X66859) IMP dehydrogenase
[Acinetobacter calcoaceticus]
Length = 488
Score = 417 bits (1061), Expect = e-115
Identities = 231/477 (48%), Positives = 320/477 (66%), Gaps = 12/477 (2%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLL+P + V PKDV + T++T + LNIP++SAAMDTVTE MA+AMA+ GG+G+
Sbjct: 10 TFDDVLLLPAYSTVLPKDVSLKTRLTRGIYLNIPLVSAAMDTVTESRMAIAMAQNGGIGI 69
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKV 135
+H+NM I Q +V+RVKK E +V+D IT+SPE TV + + ++I G+PVV++ KV
Sbjct: 70 LHKNMDIAAQAAEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISGVPVVKDSKV 129
Query: 136 VGIISKKDIAAREG--KLVKELMTKD--VITVPENIEVEEALKIMIENRIDRLPVVDKEG 191
VGI++ +D + V +MT ++TV E E ++ ++RI+++ VV +
Sbjct: 130 VGIVTGRDTRFETNLEQPVSNIMTGQDRLVTVREGESKENIQALLQKHRIEKVLVVGESN 189
Query: 192 RLIGLITMSDLVARKKYKNAVRDENGELLVAAAV-SPFDIRRAIE-LDRAGADVIVVDTA 249
L GLIT++D + Y N+ +D+ G L V AAV + D +E L AG DVIVVDTA
Sbjct: 190 ELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAGVDVIVVDTA 249
Query: 250 HAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAVKVGIGPGSICTTRIV 306
H H+ I+ ++ ++Q I GNIA A L ADAVKVGIGPGSICTTRIV
Sbjct: 250 HGHSAGVIERVRWVKQNFPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIV 309
Query: 307 AGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEA 366
AG+G+PQI+AI VA ++ + +IADGGI +SGD+ KAI AGA +M+G+LLAGT+EA
Sbjct: 310 AGIGMPQISAIDSVASALKDQ-IPLIADGGIPFSGDMAKAIGAGASTIMVGSLLAGTEEA 368
Query: 367 PGKEVIINGRKYKQYRGMGSLGAM--MKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTV 424
PG+ GR YK YRGMGSLGAM G A+RY+Q K VPEG+EG VPY+G +
Sbjct: 369 PGEVEFFQGRYYKAYRGMGSLGAMAGRTGSADRYFQDSKAGAEKLVPEGIEGRVPYKGPM 428
Query: 425 SEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
+++Q++GGL++ MGY G+ I++L++ +FV ITSAG+ ESH HD+ IT EAPNY
Sbjct: 429 GNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITKEAPNY 485
>emb|CAA26133.1| (X02209) IMP dehydrogenase subunit [Escherichia coli]
Length = 511
Score = 416 bits (1059), Expect = e-115
Identities = 236/486 (48%), Positives = 315/486 (64%), Gaps = 11/486 (2%)
Query: 8 LERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAM 67
L A TFDDVLL+P + V P D+STQ+T ++LNIP+LSAAMDTVTE +A+A+
Sbjct: 25 LRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIAL 84
Query: 68 AREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGL 127
A+EGG+G IH+NMSIE Q E+V+RVKK E +V D T+ P T+ L E++ G
Sbjct: 85 AQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGY 144
Query: 128 PVV-ENEKVVGIISKKDI--AAREGKLVKELMT--KDVITVPENIEVEEALKIMIENRID 182
PVV E ++VGII+ +D+ + V MT + ++TV E E L M E R++
Sbjct: 145 PVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVE 204
Query: 183 RLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--DIRRAIELDRAG 240
+ VVD E LIG+IT+ D + NA +DE G L V AAV + R L AG
Sbjct: 205 KALVVDDEFHLIGMITVKDFQKAEAKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAG 264
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGP 297
DV+++D++H H+ ++ ++E R K D I GN+A L A AVKVGIGP
Sbjct: 265 VDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGP 324
Query: 298 GSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLG 357
GSICTTRIV GVGVPQITA+A + + G+ VIADGGI++SGDI KAIAAGA AVM+G
Sbjct: 325 GSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVG 384
Query: 358 NLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGV 417
++LAGT+E+PG+ + GR YK YRGMGSLGAM KG ++RY+Q K VPEG+EG
Sbjct: 385 SMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSD-NAADKLVPEGIEGR 443
Query: 418 VPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNE 477
V Y+G + E+++Q +GGL++ MG G I EL+ K EFV I+ AG++ESH HD+ IT E
Sbjct: 444 VAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE 503
Query: 478 APNYPL 483
+PNY L
Sbjct: 504 SPNYRL 509
>gb|AAB18618.1| (M10101) IMP dehydrogenase [Escherichia coli]
Length = 488
Score = 416 bits (1059), Expect = e-115
Identities = 236/486 (48%), Positives = 315/486 (64%), Gaps = 11/486 (2%)
Query: 8 LERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAM 67
L A TFDDVLL+P + V P D+STQ+T ++LNIP+LSAAMDTVTE +A+A+
Sbjct: 2 LRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIAL 61
Query: 68 AREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGL 127
A+EGG+G IH+NMSIE Q E+V+RVKK E +V D T+ P T+ L E++ G
Sbjct: 62 AQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGY 121
Query: 128 PVV-ENEKVVGIISKKDI--AAREGKLVKELMT--KDVITVPENIEVEEALKIMIENRID 182
PVV E ++VGII+ +D+ + V MT + ++TV E E L M E R++
Sbjct: 122 PVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVE 181
Query: 183 RLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--DIRRAIELDRAG 240
+ VVD E LIG+IT+ D + NA +DE G L V AAV + R L AG
Sbjct: 182 KALVVDDEFHLIGMITVKDFQKAEAKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAG 241
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGP 297
DV+++D++H H+ ++ ++E R K D I GN+A L A AVKVGIGP
Sbjct: 242 VDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGP 301
Query: 298 GSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLG 357
GSICTTRIV GVGVPQITA+A + + G+ VIADGGI++SGDI KAIAAGA AVM+G
Sbjct: 302 GSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVG 361
Query: 358 NLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGV 417
++LAGT+E+PG+ + GR YK YRGMGSLGAM KG ++RY+Q K VPEG+EG
Sbjct: 362 SMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSD-NAADKLVPEGIEGR 420
Query: 418 VPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNE 477
V Y+G + E+++Q +GGL++ MG G I EL+ K EFV I+ AG++ESH HD+ IT E
Sbjct: 421 VAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE 480
Query: 478 APNYPL 483
+PNY L
Sbjct: 481 SPNYRL 486
>pir||C82282 inosine-5'-monophosphate dehydrogenase VC0767 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9655214|gb|AAF93932.1| (AE004162)
inosine-5`-monophosphate dehydrogenase [Vibrio cholerae]
Length = 489
Score = 412 bits (1048), Expect = e-114
Identities = 229/486 (47%), Positives = 319/486 (65%), Gaps = 11/486 (2%)
Query: 8 LERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAM 67
L A TFDDVLL+P + V P D+ T++T N+ LNIP++SA+MDTVTE +A+A+
Sbjct: 4 LRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLAIAL 63
Query: 68 AREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGL 127
A+EGG+G IH+NMSIE+Q QV +VK E +V +T+ PE+T+ + L H G
Sbjct: 64 AQEGGIGFIHKNMSIEQQAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGFAGF 123
Query: 128 PVV-ENEKVVGIISKKDI--AAREGKLVKELMT--KDVITVPENIEVEEALKIMIENRID 182
PVV EN ++VGII+ +D+ K V +MT + + TV E E + M + R++
Sbjct: 124 PVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKERLATVKEGATGAEVQEKMHKARVE 183
Query: 183 RLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV--SPFDIRRAIELDRAG 240
++ VV+ E +L G+IT D + NA +DE G L V AAV +P + R L AG
Sbjct: 184 KILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALVEAG 243
Query: 241 ADVIVVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDLTFA--DAVKVGIGP 297
DV+++D++H H+ ++ ++E R + I GN+A + L A AVKVGIGP
Sbjct: 244 VDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVGIGP 303
Query: 298 GSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLG 357
GSICTTRIV GVGVPQITAIA A A EYG+ VIADGGI++SGDI KAIAAGA VM+G
Sbjct: 304 GSICTTRIVTGVGVPQITAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVG 363
Query: 358 NLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGV 417
++ AGT+EAPG+ ++ GR YK YRGMGSLGAM KG ++RY+Q K VPEG+EG
Sbjct: 364 SMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGSSDRYFQTD-NAADKLVPEGIEGR 422
Query: 418 VPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNE 477
+ Y+G + E+++Q +GGL++ MG G+ +++L+ K +FV I+ AG++ESH HD+ IT E
Sbjct: 423 IAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQITKE 482
Query: 478 APNYPL 483
APNY L
Sbjct: 483 APNYRL 488
>emb|CAA09265.1| (AJ010601) inosine 5' monophosphate dehydrogenase [Streptomyces
coelicolor A3(2)]
Length = 523
Score = 348 bits (884), Expect = 7e-95
Identities = 218/499 (43%), Positives = 305/499 (60%), Gaps = 26/499 (5%)
Query: 11 AIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVK-----LNIPILS-AAMDTVTEW-EM 63
A G T+D+VLL+P A+ ++ + P + NIP S AAMD V E+
Sbjct: 27 ATLGLTYDNVLLLPGASAGASRNA--VEHLVPGISPQRCGFNIPGCSPAAMDKVDRVPEL 84
Query: 64 AVAMAREGGLGV-IHRNMSIE-EQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
A++MAR+GG+GV +SIE + + +K++E +V + ITI P+ T+ A L K
Sbjct: 85 AISMARQGGVGVPCTATLSIEGTRPTRSTWLKRSESGMVANPITIHPDSTLAEADALCAK 144
Query: 122 HDIDGLPVVENE-KVVGIISKKDIAAR--EGKLVKELMTK-DVITVPENIEVEEALKIMI 177
I G+PV + K++GI++ +D+A + V+E+MT ++T I EA+ ++
Sbjct: 145 FRISGVPVTDGAGKLLGIVTNRDMAFETDRSRQVREVMTPMPLVTGQVGISGVEAMDLLR 204
Query: 178 ENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV--SPFDIRRAIE 235
++I++LP+VD +G L GLIT+ D V ++Y +A +D G LLV AAV SP + RA
Sbjct: 205 RHKIEKLPLVDGDGILKGLITVKDFVKAEQYPHAAKDAKGRLLVGAAVGASPEALDRAQA 264
Query: 236 LDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFA--DAVKV 293
L AG D +VVDT+H HN A+ ++ + V D + GN+A L A D +KV
Sbjct: 265 LAEAGVDFLVVDTSHGHNSNALSSISKNESSVGIDVVGGNVATRDGAQALIDAGVDGIKV 324
Query: 294 GIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADA 353
G+GPGSICT R+VAG+GVPQ+TAI + A+ G+ +I DGG+ YS DI KA+AAGAD+
Sbjct: 325 GVGPGSICTPRVVAGIGVPQVTAIYEASLAARAAGVPLIGDGGLHYSRDIGKALAAGADS 384
Query: 354 VMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGG------AERYYQGGYMKTR 407
VMLG LLAG PG+ ING+++K YR MGSLGA+ G +RY+Q
Sbjct: 385 VMLGTLLAGCPGVPGELHFINGKQFKSYRRMGSLGALQSLGQAGGHFKDRYFQAQVASDD 444
Query: 408 KFVPEGVEGVVPYRGTVSEVLYQLVGGLK-AGMGYVGARNIKELKEKGEFVIITSAGLRE 466
K VPEG+EG VPYRG ++ VL+QLVGGL+ VGA I+E++ KG FV ITSAG E
Sbjct: 445 KLVPEGIEGQVPYRGPLANVLHQLVGGLRPRRWATVGAATIEEMESKGRFVRITSAGRPE 504
Query: 467 SHPHDIIITNEAPNYPLEK 485
SHPHDI +T EAPNY K
Sbjct: 505 SHPHDIQMTVEAPNYSRSK 523
>gi|11497009 IMP dehydrogenase (guaB) [Borrelia burgdorferi]
>gi|1352459|sp|P49058|IMDH_BORBU
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP
DEHYDROGENASE) (IMPDH) (IMPD) >gi|2117505|pir||I40154
IMP dehydrogenase - Lyme disease spirochete (fragment)
>gi|7427692|pir||E70218 IMP dehydrogenase (EC 1.1.1.205)
guaB - Lyme disease spirochete plasmid B/cp26
>gi|7546357|pdb|1EEP|B Chain B, 2.4 A Resolution Crystal
Structure Of Borrelia Burgdorferi Inosine
5'-Monphosphate Dehydrogenase In Complex With A Sulfate
Ion >gi|7546356|pdb|1EEP|A Chain A, 2.4 A Resolution
Crystal Structure Of Borrelia Burgdorferi Inosine
5'-Monphosphate Dehydrogenase In Complex With A Sulfate
Ion >gi|532792|gb|AAA53247.1| (U13372) IMP dehydrogenase
[Borrelia burgdorferi] >gi|2689886|gb|AAC66314.1|
(AE000792) IMP dehydrogenase (guaB) [Borrelia
burgdorferi]
Length = 404
Score = 305 bits (774), Expect = 5e-82
Identities = 183/459 (39%), Positives = 265/459 (56%), Gaps = 71/459 (15%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDV LIP+ + V P +V + TQ+T N+ LNIP LS+AMDTVTE +MA+A+A+EGG+G+
Sbjct: 11 TFDDVSLIPRKSSVLPSEVSLKTQLTKNISLNIPFLSSAMDTVTESQMAIAIAKEGGIGI 70
Query: 76 IHRNMSIEEQVEQVKRVK--KAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
IH+NMSIE Q +++++VK K ++ I + T + + A +EK D +N
Sbjct: 71 IHKNMSIEAQRKEIEKVKTYKFQKTINTNGDTNEQKPEIFTAKQHLEKSD-----AYKNA 125
Query: 134 KVVGIISKKDIAAREGKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRL 193
+ K+D L +L +++ +I+ E ++ +++ +D L + G
Sbjct: 126 E-----HKEDFPNACKDLNNKLRVGAAVSI--DIDTIERVEELVKAHVDILVIDSAHGHS 178
Query: 194 IGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDTAHAHN 253
+I + + + KY N +L+ V+ A++L GAD
Sbjct: 179 TRIIELIKKI-KTKYPNL------DLIAGNIVTK---EAALDLISVGAD----------- 217
Query: 254 LKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFADAVKVGIGPGSICTTRIVAGVGVPQ 313
+KVGIGPGSICTTRIVAGVGVPQ
Sbjct: 218 ------------------------------------CLKVGIGPGSICTTRIVAGVGVPQ 241
Query: 314 ITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVII 373
ITAI V + + +IADGGI++SGD+VKAIAAGAD+VM+GNL AGTKE+P +E+I
Sbjct: 242 ITAICDVYEACNNTNICIIADGGIRFSGDVVKAIAAGADSVMIGNLFAGTKESPSEEIIY 301
Query: 374 NGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVG 433
NG+K+K Y GMGS+ AM +G RY+Q + +K VPEG+EG+VPY G + ++L QL G
Sbjct: 302 NGKKFKSYVGMGSISAMKRGSKSRYFQLENNEPKKLVPEGIEGMVPYSGKLKDILTQLKG 361
Query: 434 GLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDI 472
GL +GMGY+GA I +LK +FV I+ + L+ESHPHD+
Sbjct: 362 GLMSGMGYLGAATISDLKINSKFVKISHSSLKESHPHDV 400
>sp|Q07152|IMDH_DROME INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) (RASPBERRY PROTEIN) >gi|542584|pir||S41064 IMP
dehydrogenase (EC 1.1.1.205) impdh - fruit fly
(Drosophila melanogaster) >gi|2133680|pir||S61482
inosine monophosphate dehydrogenase - fruit fly
(Drosophila melanogaster) >gi|348102|gb|AAA16839.1|
(L22608) inosine monophosphate dehydrogenase [Drosophila
melanogaster] >gi|387594|gb|AAA21831.1| (L14847) inosine
monophosphate dehydrogenase [Drosophila melanogaster]
>gi|7291188|gb|AAF46621.1| (AE003451) ras gene product
[alt 2] [Drosophila melanogaster]
>gi|7291189|gb|AAF46622.1| (AE003451) ras gene product
[alt 1] [Drosophila melanogaster]
Length = 537
Score = 290 bits (734), Expect = 3e-77
Identities = 175/468 (37%), Positives = 277/468 (58%), Gaps = 19/468 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G K+L + G T++D L++P + ++VD+S+ +T ++ L P++S+ MDTVTE
Sbjct: 39 GLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTES 98
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
EMA+AMA GG+G+IH N + E Q +V +VKK + + D +SP TV L K
Sbjct: 99 EMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRK 158
Query: 122 HDIDGLPVVENEKV----VGIISKKDIAAREGK---LVKELMTKDVITVPENIEVEEALK 174
+ G PV EN K+ +G+++ +DI RE + L+ ++MT +++T P I + A
Sbjct: 159 NGFTGYPVTENGKLGGKLLGMVTSRDIDFRENQPEVLLADIMTTELVTAPNGINLPTANA 218
Query: 175 IMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--DIRR 232
I+ +++ +LP+V++ G L+ +I +DL + Y NA +D N +LLV AA+ D R
Sbjct: 219 ILEKSKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKAR 278
Query: 233 AIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--D 289
L G DVI++D++ +++ ++ +K +++ + I GN+ +L A D
Sbjct: 279 LALLVANGVDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVD 338
Query: 290 AVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAA 349
++VG+G GSIC T+ V G PQ TA+ V+ A+++G+ VIADGGI+ G IVKAIA
Sbjct: 339 GLRVGMGSGSICITQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIAL 398
Query: 350 GADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAE-----RYYQGGYM 404
GA AVM+G+LLAGT EAPG+ +G + K+YRGMGSL AM +G A+ RYY
Sbjct: 399 GASAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMD 458
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
K + V +GV G + +G+V L L GL+ +GA +I +L++
Sbjct: 459 KMK--VAQGVSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRD 504
>pir||T40127 IMP dehydrogenase (EC 1.1.1.205) SPBC2F12.14c - fission yeast
(Schizosaccharomyces pombe) >gi|2239243|emb|CAB10161.1|
(Z97211) probable inosine-5'-monophosphate dehydrogenase
[Schizosaccharomyces pombe]
Length = 524
Score = 283 bits (717), Expect = 3e-75
Identities = 175/477 (36%), Positives = 279/477 (57%), Gaps = 26/477 (5%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G TF+D L++P + P +V + T+I+ N+ L P +S+ MDTVTE +MA+ MA GG+
Sbjct: 36 GLTFNDFLILPGYIDFVPNNVSLETRISRNIVLKTPFMSSPMDTVTEDQMAIYMALLGGI 95
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
GVIH N + EEQ V++VKK E + D + SP+ TV L + E G+P+ EN
Sbjct: 96 GVIHHNCTPEEQAAMVRKVKKYENGFILDPVVFSPQHTVGDVLKIKETKGFSGIPITENG 155
Query: 134 KV----VGIISKKDIAARE--GKLVKELMT--KDVITVPENIEVEEALKIMIENRIDRLP 185
K+ VGI++ +D+ + V E+MT +++IT E I +E A +++ +++ +LP
Sbjct: 156 KLRGKLVGIVTSRDVQFHKDTNTPVTEVMTPREELITTAEGISLERANEMLRKSKKGKLP 215
Query: 186 VVDKEGRLIGLITMSDLVARKKYKNAVR-DENGELLVAAAVSPFDIRRA--IELDRAGAD 242
VVDK+ L+ L++++DL+ + A + + +L+VAAA+ D R L AG D
Sbjct: 216 VVDKDDNLVALLSLTDLMKNLHFPLASKTSDTKQLMVAAAIGTRDDDRTRLALLAEAGLD 275
Query: 243 VIVVDTAHAHN---LKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFA--DAVKVGIGP 297
+V+D++ ++ ++ IK +K+ K+D I GN+ + L A D ++VG+G
Sbjct: 276 AVVIDSSQGNSCFQIEMIKWIKKTYPKIDV--IAGNVVTREQTASLIAAGADGLRVGMGS 333
Query: 298 GSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLG 357
GS C T+ V G PQ TAIA VA+ A ++G+ VIADGGI+ G +VK+++ GA AVM+G
Sbjct: 334 GSACITQEVMACGRPQATAIAQVAEFASQFGIGVIADGGIQNVGHMVKSLSLGATAVMMG 393
Query: 358 NLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRK---FVPEGV 414
LLAGT E+PG+ + G++YK YRGMGS+ AM G + G + V +GV
Sbjct: 394 GLLAGTTESPGEYYVREGQRYKSYRGMGSIAAMEGTGVNKNASTGRYFSENDAVRVAQGV 453
Query: 415 EGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKEL-----KEKGEFVIITSAGLRE 466
G+V +G++ L L GL+ + +G +++ EL K + F + +SA +RE
Sbjct: 454 SGLVVDKGSLLRFLPYLYTGLQHALQDIGTKSLDELHEAVDKHEVRFELRSSAAIRE 510
>pir||D72631 probable IMP dehydrogenase (EC 1.1.1.205) APE1507 [similarity] -
Aeropyrum pernix (strain K1) >gi|5105192|dbj|BAA80506.1|
(AP000061) 444aa long hypothetical IMP dehydrogenase
[Aeropyrum pernix]
Length = 444
Score = 277 bits (701), Expect = 2e-73
Identities = 172/469 (36%), Positives = 254/469 (53%), Gaps = 61/469 (13%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDV ++P + VEP DV++S++++ ++ ++ P++S+ MDTVTEW MA A+AR G +GV
Sbjct: 26 TFDDVAILPGLSTVEPHDVELSSRVSRSIFVSTPLVSSPMDTVTEWRMAAALARLGAVGV 85
Query: 76 IHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKV 135
IHRNM EEQ V VK +V I + ++ ++E+ D V ++ +
Sbjct: 86 IHRNMPREEQARHVSMVKSVSPSPWSEVPRIRLPDGLENYSLILEELDAGAAVVFGDDGI 145
Query: 136 VGIISKKDIAAREGKLVKELMTKDVITVPE-NIEVEEALKIMIE-NRIDRLPVVDKEGRL 193
G + V+ P+ + +E+A + + RI P +D EGRL
Sbjct: 146 KGYL--------------------VLERPDAQLWLEKARYLSLYLTRIRPFPTIDGEGRL 185
Query: 194 IGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDTAHAHN 253
+ V AAVSPFD+ RA L+++GAD +V+D AH HN
Sbjct: 186 V--------------------------VGAAVSPFDLDRARLLEKSGADFLVIDVAHLHN 219
Query: 254 LKAIKAMKEMRQKVDADFIVGNIANPKAV-DDLTFADAV---KVGIGPGSICTTRIVAGV 309
A+ ++ + ++V D + GN+ + V D L A+ V ++GI GSIC+T VAG
Sbjct: 220 RNALSSLSRLVKEVSIDVVAGNLGTREGVLDTLARAEEVAGLRMGISSGSICSTGEVAGA 279
Query: 310 GVPQITAIAMVADRAQEYGLY----VIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKE 365
VP +TA+ +E GL +IADGG++ +GD KAI AGA AVM G L AG E
Sbjct: 280 AVPTLTAVMNAVLALEELGLAGRIPIIADGGVRNAGDAAKAIIAGASAVMGGRLFAGADE 339
Query: 366 APGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVS 425
+PG + + + YK YRGM S GAM + R+ Y + K V EGVEG+VPY G V
Sbjct: 340 SPGPRIRVGDKLYKPYRGMASRGAMER----RFAVDRYSRQAKAVEEGVEGLVPYTGPVV 395
Query: 426 EVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIII 474
+ LY+L GLKA +GY GA+++ K + +T G RE PHDI++
Sbjct: 396 KTLYELAEGLKAALGYAGAQDVTS-AWKAKLARVTPTGSREIRPHDILL 443
>gb|AAF13230.1|AF196975_1 (AF196975) inosine 5'-monophosphate dehydrogenase [Pneumocystis
carinii]
Length = 529
Score = 275 bits (696), Expect = 7e-73
Identities = 174/485 (35%), Positives = 279/485 (56%), Gaps = 29/485 (5%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D++++P + E V + + IT + L P +S+ MDTVTE +MA+ +A GG+
Sbjct: 39 GLTYNDIIILPGYIDFEVNSVSLESHITKKIVLKTPFMSSPMDTVTESDMAINLALLGGI 98
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVE-- 131
GVIH N +IEEQ E V++VKK E + I +S V + E+ G+P+ +
Sbjct: 99 GVIHHNCTIEEQTEMVRKVKKFENGFITSPIVLSLNHRVRDVRRIKEELGFSGIPITDTG 158
Query: 132 --NEKVVGIISKKDIAAREG--KLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
N K++GI++ +DI + E+MTKD++T E I +EEA +I+ + +LP+V
Sbjct: 159 QLNGKLLGIVTSRDIQFHNNDESFLSEVMTKDLVTGSEGIRLEEANEILRSCKKGKLPIV 218
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVR-DENGELLVAAAVS--PFDIRRAIELDRAGADVI 244
DKEG L L++ SDL+ + A + ++ +L+ AAAV P D R L AG D++
Sbjct: 219 DKEGNLTALLSRSDLMKNLHFPLASKLPDSKQLICAAAVGTRPDDRIRLKHLVEAGLDIV 278
Query: 245 VVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSIC 301
V+D++ +++ I +K ++++ + + I GN+ + +L A DA++VG+G GSIC
Sbjct: 279 VLDSSQGNSIYQINMIKWIKKEFPNLEVIAGNVVTREQAANLISAGADALRVGMGSGSIC 338
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
T+ + VG PQ TA+ V++ A ++G+ IADGGI+ G I KA+A GA AVM+GNLLA
Sbjct: 339 ITQEIMAVGRPQATAVYAVSEFASKFGVPTIADGGIENIGHITKALALGASAVMMGNLLA 398
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMM---------KGGAERYYQGGYMKTRKFVPE 412
GT E+PG+ +G++ K YRGMGS+ AM + RY+ G T + V +
Sbjct: 399 GTTESPGQYYYRDGQRLKSYRGMGSIDAMEHLSGKNKGDNAASSRYF--GEADTIR-VAQ 455
Query: 413 GVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNI----KELKEKG-EFVIITSAGLRES 467
GV G V +G++ + L GL+ + +G +N+ K++KEK F T A E
Sbjct: 456 GVSGSVIDKGSLHVYVPYLRTGLQHSLQDIGVQNLTELRKQVKEKNIRFEFRTVASQLEG 515
Query: 468 HPHDI 472
+ H +
Sbjct: 516 NVHGL 520
>pir||E81701 probable IMP dehydrogenase (EC 1.1.1.205) TC0443 [similarity] -
Chlamydia muridarum (strain Nigg)
>gi|7190488|gb|AAF39297.1| (AE002313)
inosine-5`-monophosphate dehydrogenase, putative
[Chlamydia muridarum]
Length = 357
Score = 274 bits (694), Expect = 1e-72
Identities = 141/266 (53%), Positives = 184/266 (69%), Gaps = 4/266 (1%)
Query: 222 AAAVSPFDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKA 281
A + + RA L AG D +VVDTAH H+ + +++ IVGNI + A
Sbjct: 94 AVGIGQQGLERAEALVEAGIDTLVVDTAHGHSKLVLDTAFTIKKNYPVTLIVGNIVSKAA 153
Query: 282 VDDLTF--ADAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKY 339
L DAVKVGIGPGSICTTRIV+GVG+PQ+TAI VA+ + + +IADGG++Y
Sbjct: 154 ALCLAEIGVDAVKVGIGPGSICTTRIVSGVGLPQLTAIMDVAEALHDSSVRIIADGGMRY 213
Query: 340 SGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYY 399
SGDIVKA+AAGA VMLG++LAGT EAPG+ V IN YK YRGMGSLGAM KG AERY+
Sbjct: 214 SGDIVKALAAGAHCVMLGSMLAGTDEAPGEIVQINEHSYKMYRGMGSLGAMKKGSAERYF 273
Query: 400 QGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVII 459
Q +KFVPEGVEG+VPY+G++ +VLYQ++GG+++GMGY+GA N++EL++ F I
Sbjct: 274 QKN--NAKKFVPEGVEGLVPYKGSLHDVLYQILGGIRSGMGYLGAHNLEELRQNAVFSRI 331
Query: 460 TSAGLRESHPHDIIITNEAPNYPLEK 485
T +G ESH H++ APNY + K
Sbjct: 332 THSGRSESHIHNLQYIQHAPNYQISK 357
Score = 90.9 bits (222), Expect = 3e-17
Identities = 42/78 (53%), Positives = 60/78 (76%)
Query: 16 TFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGV 75
TFDDVLL+PQ +EV P+D +++ ++ ++ L IPILSAAMD+VTE MA AM+ GGLG+
Sbjct: 6 TFDDVLLVPQYSEVLPQDACLTSSVSESLSLTIPILSAAMDSVTELSMATAMSVAGGLGI 65
Query: 76 IHRNMSIEEQVEQVKRVK 93
+H+NM + QV VK++K
Sbjct: 66 VHKNMDVNAQVAIVKQIK 83
>gi|6322012 IMP dehydrogenase; probable PUR5 gene; Imd2p [Saccharomyces
cerevisiae] >gi|729848|sp|P38697|IMH1_YEAST PROBABLE
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP
DEHYDROGENASE) (IMPDH) (IMPD) >gi|626391|pir||S48997 IMP
dehydrogenase (EC 1.1.1.205) PUR5 - yeast (Saccharomyces
cerevisiae) >gi|458916|gb|AAB69728.1| (U00029) Yhr216wp
[Saccharomyces cerevisiae]
Length = 523
Score = 271 bits (686), Expect = 1e-71
Identities = 166/483 (34%), Positives = 273/483 (56%), Gaps = 28/483 (5%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D L++P + +V + T++T N+ LNIP++S+ MDTVTE EMA MA GG+
Sbjct: 36 GLTYNDFLILPGLVDFASSEVSLQTKLTRNITLNIPLVSSPMDTVTESEMATFMALLGGI 95
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV--- 130
G IH N + E+Q + V+RVK E + + I ISP TV A + EK+ G PV
Sbjct: 96 GFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKEKYGFAGFPVTTDG 155
Query: 131 -ENEKVVGIISKKDIAAREGK--LVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
N K+VG+I+ +DI E LV+++MTK+ +T + I + E +I+ + + RL VV
Sbjct: 156 KRNAKLVGVITSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGRLLVV 215
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRDENG-ELLVAAAVSPFDI--RRAIELDRAGADVI 244
D++G L+ +++ +DL+ + Y A + N +LL A++ D R L +AG DV+
Sbjct: 216 DEKGNLVSMLSRTDLMKNQNYPLASKSANTKQLLCGASIGTMDADKERLRLLVKAGLDVV 275
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVDA-DFIVGNIANPKAVDDLTFA--DAVKVGIGPGSIC 301
++D++ +++ + +K +++ + I GN+ + +L A D +++G+G GSIC
Sbjct: 276 ILDSSQGNSIFELNMLKWVKESFPGLEVIAGNVVTREQAANLIAAGADGLRIGMGTGSIC 335
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
T+ V G PQ TA+ V + A ++G+ +ADGG++ G I KA+A G+ VM+G +LA
Sbjct: 336 ITQEVMACGRPQGTAVYNVCEFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLA 395
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKF-------VPEGV 414
GT E+PG+ +G++ K YRGMGS+ AM K G +G +R F V +GV
Sbjct: 396 GTTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGT----KGNASTSRYFSESDSVLVAQGV 451
Query: 415 EGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE-----KGEFVIITSAGLRESHP 469
G V +G++ + + L GL+ +G R++ LK K F T++ E
Sbjct: 452 SGAVVDKGSIKKFIPYLYNGLQHSCQDIGCRSLTLLKNNVQRGKVRFEFRTASAQLEGGV 511
Query: 470 HDI 472
H++
Sbjct: 512 HNL 514
>sp|O00086|IMH3_CANAL PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE)
(IMPDH) (IMPD) >gi|1930016|gb|AAB51509.1| (U85049)
putative inosine-5'-monophosphate dehydrogenase [Candida
albicans]
Length = 521
Score = 270 bits (684), Expect = 2e-71
Identities = 166/457 (36%), Positives = 256/457 (55%), Gaps = 21/457 (4%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D L++P V + T++T + L P +S+ MDTVTE MA+ MA GG+
Sbjct: 34 GLTYNDFLILPGLINFPSSAVSLETKLTKKITLKSPFVSSPMDTVTEENMAIHMALLGGI 93
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
G+IH N + EEQ E V++VKK E + D + ISPE TV + E PV EN
Sbjct: 94 GIIHHNCTSEEQAEMVRKVKKYENGFINDPVVISPEVTVGEVKKMGEVLGFTSFPVTENG 153
Query: 134 KV----VGIISKKDIAAREGKL--VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
KV VGII+ +DI E V E+MTKD++ + I + + +++ ++ +LP+V
Sbjct: 154 KVGGKLVGIITSRDIQFHEDNKSPVSEVMTKDLVVGKKGISLTDGNELLRSSKKGKLPIV 213
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRD-ENGELLVAAAVSPFDI--RRAIELDRAGADVI 244
D EG L+ LI+ +DL + Y NA + + +LL AA+ D R +L AG DV+
Sbjct: 214 DAEGNLVSLISRTDLQKNQDYPNASKSFHSKQLLCGAAIGTIDADRERLDKLVEAGLDVV 273
Query: 245 VVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAVKVGIGPGSIC 301
V+D+++ ++ + +K +++K + I GN+ + L ADA+++G+G GSIC
Sbjct: 274 VLDSSNGSSVFQLNMIKWIKEKYPELQVIAGNVVTREQAALLIEAGADALRIGMGSGSIC 333
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
T+ V G PQ TA+ V + A ++G+ IADGGI G I KA+A GA VM+G LLA
Sbjct: 334 ITQEVMACGRPQGTAVYGVTEFANKFGVPCIADGGIGNIGHITKALALGASCVMMGGLLA 393
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMMK------GGAERYYQGGYMKTRKFVPEGVE 415
GT E PG +G++ K YRGMGS+ AM + RY+ + V +GV
Sbjct: 394 GTAETPGDYFYRDGKRLKTYRGMGSIDAMQQTNTNANASTSRYFSEA---DKVLVAQGVS 450
Query: 416 GVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
G V +G++++ + L GL+ + +G ++I EL+E
Sbjct: 451 GSVVDKGSITKFVPYLYNGLQHSLQDIGIKSIDELRE 487
>sp|P12269|IMD2_MESAU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (IMP DEHYDROGENASE 2)
(IMPDH-II) (IMPD 2) >gi|90204|pir||B31997 IMP
dehydrogenase (EC 1.1.1.205) - Chinese hamster
>gi|304517|gb|AAA36993.1| (J04209)
inosine-5'-monophosphate dehydrogenase [Cricetulus
griseus]
Length = 514
Score = 269 bits (680), Expect = 6e-71
Identities = 162/467 (34%), Positives = 268/467 (56%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A++L G T++D L++P + VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
MA+AMA GG+G IH N + E Q +V++VKK E+ + D + +SP++ V +
Sbjct: 77 GMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKAR 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDI----AAREGKLVKELMTK--DVITVPENIEVEE 171
H G+P+ + ++VGIIS +DI + ++E+MTK D++ P I ++E
Sbjct: 137 HGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGITLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V++ L+ +I +DL + Y A +D +LL AA+ D
Sbjct: 197 ANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA 288
R L AG DV+V+D++ +++ I +K M++K + I GN+ +L A
Sbjct: 257 KYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYMKEKYPNLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
DA++VG+G GSIC T+ V G PQ TA+ V++ A+ +G+ VIADGGI+ G I KA
Sbjct: 317 GVDALRVGMGCGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMK--GGAERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRGMGSL AM K RY+
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEA-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ V +GV G V +G++ + + L+ G++ +GA+++ +++
Sbjct: 435 -DKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR 480
>gb|AAF70813.1|AF249293_1 (AF249293) putative inosine 5-monophosphate dehydrogenase [Candida
albicans]
Length = 521
Score = 268 bits (679), Expect = 7e-71
Identities = 165/457 (36%), Positives = 255/457 (55%), Gaps = 21/457 (4%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D L++P V + T++T + L P +S+ MDTVTE MA+ MA GG+
Sbjct: 34 GLTYNDFLILPGLVNFPSSAVSLETKLTKKITLKSPFVSSPMDTVTEENMAIHMALLGGI 93
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
G+IH N + EEQ E V++VKK E + D + ISPE TV + E PV EN
Sbjct: 94 GIIHHNCTAEEQAEMVRKVKKYENGFINDPVVISPEVTVGEVKKMGEVLGFTSFPVTENG 153
Query: 134 KV----VGIISKKDIAAREGKL--VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
KV VGII+ +DI E V E+MTKD++ + I + + +++ ++ +LP+V
Sbjct: 154 KVGGKLVGIITSRDIQFHEDNKSPVSEVMTKDLVVGKKGISLTDGNELLRSSKKGKLPIV 213
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRD-ENGELLVAAAVSPFDI--RRAIELDRAGADVI 244
D EG L+ LI+ +DL + Y NA + + +LL AA+ D R +L AG DV+
Sbjct: 214 DAEGNLVSLISRTDLQKNQDYPNASKSFHSKQLLCGAAIGTIDADRERLDKLVEAGLDVV 273
Query: 245 VVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAVKVGIGPGSIC 301
V+D+++ ++ + +K +++K + I GN+ + L ADA+++G+G GSIC
Sbjct: 274 VLDSSNGSSVFQLNMIKWIKEKYPELQVIAGNVVTREQAALLIEAGADALRIGMGSGSIC 333
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
T+ V G PQ TA+ V + A ++G+ IADGGI G I KA+A GA VM+G LLA
Sbjct: 334 ITQEVMACGRPQGTAVYGVTEFANKFGVPCIADGGIGNIGHITKALALGASCVMMGGLLA 393
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMMK------GGAERYYQGGYMKTRKFVPEGVE 415
GT E P +G++ K YRGMGS+ AM + RY+ + V +GV
Sbjct: 394 GTAETPDDYFYRDGKRLKTYRGMGSIDAMQQTNTNANASTSRYFSEA---DKVLVAQGVS 450
Query: 416 GVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
G V +G++++ + L GL+ + +G ++I EL+E
Sbjct: 451 GSVVDKGSITKFVPYLYNGLQHSLQDIGIKSIDELRE 487
>sp|P20839|IMD1_HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 (IMP DEHYDROGENASE 1)
(IMPDH-I) (IMPD 1) >gi|106722|pir||A35566 IMP
dehydrogenase (EC 1.1.1.205) I - human
Length = 514
Score = 268 bits (678), Expect = 1e-70
Identities = 163/467 (34%), Positives = 269/467 (56%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A++L + T++D L++P + +VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAQQLFASADDLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
+MA+AMA GG+G IH N + E Q +V++VK E+ + D + +SP TV L +
Sbjct: 77 DMAIAMALMGGIGFIHHNCTPEFQANEVRKVKNFEQGFITDPVVLSPSHTVGDVLEAKMR 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDIAAREGK----LVKELMTK--DVITVPENIEVEE 171
H G+P+ E K+VGI++ +DI K L+ E+MT +++ P + ++E
Sbjct: 137 HGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V+ L+ +I +DL + Y A +D +LL AAV D
Sbjct: 197 ANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDLTFA 288
R L +AG DVIV+D++ +++ I + ++QK I GN+ +L A
Sbjct: 257 KYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
D ++VG+G GSIC T+ V G PQ TA+ VA+ A+ +G+ +IADGGI+ G +VKA
Sbjct: 317 GVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGA--ERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRGMGSL AM K + +RY+ G
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEG-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ + +GV G + +G++ + + L+ G++ G +GAR++ L+
Sbjct: 435 -DKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR 480
>gi|4504689 IMP (inosine monophosphate) dehydrogenase 2; IMP (inosine
5'-phosphate) dehydrogenase-2 [Homo sapiens]
>gi|307066|gb|AAA36112.1| (J04208)
inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)
[Homo sapiens]
Length = 514
Score = 268 bits (678), Expect = 1e-70
Identities = 161/467 (34%), Positives = 271/467 (57%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A++L G T++D L++P + VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
MA+AMA GG+G IH N + E Q +V++VKK E+ + D + +SP++ V +
Sbjct: 77 GMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKAR 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDIAAREGK----LVKELMTK--DVITVPENIEVEE 171
H G+P+ + ++VGIIS +DI + + ++E+MTK D++ P +I ++E
Sbjct: 137 HGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPRSITLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V+++ L+ +I +DL + Y A +D +LL AA+ D
Sbjct: 197 ANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA 288
R L +AG DV+V+D++ +++ I +K ++ K + I GN+ +L A
Sbjct: 257 KYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
DA++VG+G GSIC T+ V G PQ TA+ V++ A+ +G+ VIADGGI+ G I KA
Sbjct: 317 GVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMK--GGAERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRGMGSL AM K RY+
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEA-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ V +GV G V +G++ + + L+ G++ +GA+++ +++
Sbjct: 435 -DKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR 480
>sp|P24547|IMD2_MOUSE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (IMP DEHYDROGENASE 2)
(IMPDH-II) (IMPD 2) >gi|110569|pir||JT0565 IMP
dehydrogenase (EC 1.1.1.205) - mouse
>gi|309413|gb|AAA39311.1| (M33934) IMP dehydrogenase (EC
1.2.1.14) [Mus musculus]
Length = 514
Score = 268 bits (677), Expect = 1e-70
Identities = 160/467 (34%), Positives = 268/467 (57%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A++L G T++D L++P + VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
MA+AMA GG+G IH N + E Q +V++VKK E+ + D + +SP++ V +
Sbjct: 77 GMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKAR 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDI----AAREGKLVKELMTK--DVITVPENIEVEE 171
H G+P+ + ++VGIIS +DI + ++E+MTK D++ P + ++E
Sbjct: 137 HGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V++ L+ +I +DL + Y A +D +LL AA+ D
Sbjct: 197 ANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDA-DFIVGNIANPKAVDDLTFA 288
R L AG DV+V+D++ +++ I +K +++K + I GN+ +L A
Sbjct: 257 KYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
DA++VG+G GSIC T+ V G PQ TA+ V++ A+ +G+ VIADGGI+ G I KA
Sbjct: 317 GVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMK--GGAERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRGMGSL AM K RY+
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEA-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ V +GV G V +G++ + + L+ G++ +GA+++ +++
Sbjct: 435 -DKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR 480
>gi|6754344 inosine 5'-phosphate dehydrogenase 1 [Mus musculus]
>gi|1708472|sp|P50096|IMD1_MOUSE
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 (IMP
DEHYDROGENASE 1) (IMPDH-I) (IMPD 1)
>gi|392948|gb|AAA18285.1| (U00978) type I inosine
monophosphate dehydrogenase [Mus musculus]
Length = 514
Score = 268 bits (677), Expect = 1e-70
Identities = 164/467 (35%), Positives = 270/467 (57%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A +L G T++D L++P + +VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAHELFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
+MA+AMA GG+G IH N + E Q +V++VKK E+ + D + +SP TV L +
Sbjct: 77 DMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQ 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDIAAREGK----LVKELMTK--DVITVPENIEVEE 171
H G+P+ K+VGI++ +DI K L+ E+MT +++ P + ++E
Sbjct: 137 HGFSGIPITATGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRVELVVAPAGVTLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V+ + L+ +I +DL + Y A +D + +LL AAV D
Sbjct: 197 ANEILQRSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDLTFA 288
R L +AGADVIV D++ +++ I + ++QK I GN+ +L A
Sbjct: 257 KYRLDLLTQAGADVIVHDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
D ++VG+G GSIC T+ V G PQ TA+ VA+ A+ +G+ VIADGGI+ G +VKA
Sbjct: 317 GVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGA--ERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRG+GSL AM K + +RY+ G
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGIGSLDAMEKSSSSQKRYFSEG-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ + +GV G + +G++ + + L+ G++ G +GA+++ L+
Sbjct: 435 -DKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAQSLSVLR 480
>sp|P12268|IMD2_HUMAN INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (IMP DEHYDROGENASE 2)
(IMPDH-II) (IMPD 2) >gi|7427690|pir||A31997 IMP
dehydrogenase (EC 1.1.1.205) II - human
>gi|4929871|pdb|1B3O|B Chain B, Ternary Complex Of Human
Type-Ii Inosine Monophosphate Dehydrogenase With
6-Cl-Imp And Selenazole Adenine Dinucleotide
>gi|4929870|pdb|1B3O|A Chain A, Ternary Complex Of Human
Type-Ii Inosine Monophosphate Dehydrogenase With
6-Cl-Imp And Selenazole Adenine Dinucleotide
>gi|602458|gb|AAA67054.1| (L33842) inosine monophosphate
dehydrogenase type II [Homo sapiens]
>gi|1702964|gb|AAB70699.1| (L39210) inosine
monophosphate dehydrogenase type II [Homo sapiens]
Length = 514
Score = 267 bits (676), Expect = 2e-70
Identities = 161/467 (34%), Positives = 270/467 (57%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A++L G T++D L++P + VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
MA+AMA GG+G IH N + E Q +V++VKK E+ + D + +SP++ V +
Sbjct: 77 GMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKAR 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDIAAREGK----LVKELMTK--DVITVPENIEVEE 171
H G+P+ + ++VGIIS +DI + + ++E+MTK D++ P I ++E
Sbjct: 137 HGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V+++ L+ +I +DL + Y A +D +LL AA+ D
Sbjct: 197 ANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA 288
R L +AG DV+V+D++ +++ I +K ++ K + I GN+ +L A
Sbjct: 257 KYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
DA++VG+G GSIC T+ V G PQ TA+ V++ A+ +G+ VIADGGI+ G I KA
Sbjct: 317 GVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMK--GGAERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRGMGSL AM K RY+
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEA-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ V +GV G V +G++ + + L+ G++ +GA+++ +++
Sbjct: 435 -DKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR 480
>gi|6323464 Imd3p [Saccharomyces cerevisiae] >gi|1708477|sp|P50095|IMH2_YEAST
PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP
DEHYDROGENASE) (IMPDH) (IMPD) >gi|1363745|pir||S59402
IMP dehydrogenase (EC 1.1.1.205) YLR432w - yeast
(Saccharomyces cerevisiae) >gi|665971|gb|AAB67516.1|
(U21094) Ylr432wp: Inosine-5'-monophosphate
dehydrogenase [Saccharomyces cerevisiae]
Length = 523
Score = 267 bits (676), Expect = 2e-70
Identities = 164/483 (33%), Positives = 271/483 (55%), Gaps = 28/483 (5%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D L++P + +V + T++T N+ LN P +S+ MDTVTE EMA+ MA GG+
Sbjct: 36 GLTYNDFLVLPGLVDFPSSEVSLQTKLTRNITLNTPFVSSPMDTVTESEMAIFMALLGGI 95
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVE-- 131
G IH N + E+Q + V+RVK E + + I ISP TV A + E+ G PV E
Sbjct: 96 GFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKERFGFSGFPVTEDG 155
Query: 132 --NEKVVGIISKKDIAAREGK--LVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
N K++GI++ +DI E LV+++MTK+ +T + I + E +I+ + + +L +V
Sbjct: 156 KRNGKLMGIVTSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGKLLIV 215
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRDENG-ELLVAAAVSPFDI--RRAIELDRAGADVI 244
D G L+ +++ +DL+ + Y A + +LL AA+ D R L AG DV+
Sbjct: 216 DDNGNLVSMLSRTDLMKNQNYPLASKSATTKQLLCGAAIGTIDADKERLRLLVEAGLDVV 275
Query: 245 VVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSIC 301
++D++ +++ + +K +++ D + I GN+A + +L A D +++G+G GSIC
Sbjct: 276 ILDSSQGNSIFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSIC 335
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
T+ V G PQ TA+ V + A ++G+ +ADGG++ G I KA+A G+ VM+G +LA
Sbjct: 336 ITQEVMACGRPQGTAVYNVCEFANQFGIPCMADGGVQNIGHITKALALGSSTVMMGGMLA 395
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKF-------VPEGV 414
GT E+PG+ +G++ K YRGMGS+ AM K G +G +R F V +GV
Sbjct: 396 GTTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGT----KGNASTSRYFSESDSVLVAQGV 451
Query: 415 EGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE-----KGEFVIITSAGLRESHP 469
G V +G++ + + L GL+ +G +++ LKE K F T++ E
Sbjct: 452 SGAVVDKGSIKKFIPYLYNGLQHSCQDIGYKSLTLLKENVQSGKVRFEFRTASAQLEGGV 511
Query: 470 HDI 472
H++
Sbjct: 512 HNL 514
>gi|11419298 IMP (inosine monophosphate) dehydrogenase 1 [Homo sapiens]
Length = 675
Score = 265 bits (670), Expect = 8e-70
Identities = 160/450 (35%), Positives = 261/450 (57%), Gaps = 20/450 (4%)
Query: 19 DVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHR 78
D L++P + +VD+++ +T + L P++S+ MDTVTE +MA+AMA GG+G IH
Sbjct: 195 DFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHH 254
Query: 79 NMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN----EK 134
N + E Q +V++VKK E+ + D + +SP TV L +H G+P+ E K
Sbjct: 255 NCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSK 314
Query: 135 VVGIISKKDIAAREGK----LVKELMTK--DVITVPENIEVEEALKIMIENRIDRLPVVD 188
+VGI++ +DI K L+ E+MT +++ P + ++EA +I+ ++ +LP+V+
Sbjct: 315 LVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVN 374
Query: 189 KEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--DIRRAIELDRAGADVIVV 246
L+ +I +DL + Y A +D +LL AAV D R L +AG DVIV+
Sbjct: 375 DCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVL 434
Query: 247 DTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTT 303
D++ +++ I + ++QK I GN+ +L A D ++VG+G GSIC T
Sbjct: 435 DSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICIT 494
Query: 304 RIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGT 363
+ V G PQ TA+ VA+ A+ +G+ +IADGGI+ G +VKA+A GA VM+G+LLA T
Sbjct: 495 QEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAAT 554
Query: 364 KEAPGKEVIINGRKYKQYRGMGSLGAMMKGGA--ERYYQGGYMKTRKFVPEGVEGVVPYR 421
EAPG+ +G + K+YRGMGSL AM K + +RY+ G + + +GV G + +
Sbjct: 555 TEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEG---DKVKIAQGVSGSIQDK 611
Query: 422 GTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
G++ + + L+ G++ G +GAR++ L+
Sbjct: 612 GSIQKFVPYLIAGIQHGCQDIGARSLSVLR 641
>gi|6754346 inosine 5'-phosphate dehydrogenase 2; IMP dehydrogenase [Mus
musculus] >gi|425158|gb|AAA20181.1| (M98333) IMP
dehydrogenase [Mus musculus]
Length = 514
Score = 264 bits (668), Expect = 1e-69
Identities = 159/467 (34%), Positives = 266/467 (56%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A++L G T++D L++P + VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
MA+AMA GG+G IH N + E Q +V++VKK E+ + D + +SP++ V +
Sbjct: 77 GMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKAR 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDI----AAREGKLVKELMTK--DVITVPENIEVEE 171
H G+P+ + ++VGIIS +DI + ++E+MTK D++ P + ++E
Sbjct: 137 HGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V++ L+ +I +DL + Y A +D +LL AA+ D
Sbjct: 197 ANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDA-DFIVGNIANPKAVDDLTFA 288
R L AG DV+V+D++ +++ I +K +++K + I GN+ +L A
Sbjct: 257 KYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
DA++VG+G GSIC + V G PQ TA+ V + A+ +G+ VIADGGI+ G I KA
Sbjct: 317 GVDALRVGMGSGSICIIQEVLACGRPQATAVYKVYEYARRFGVPVIADGGIQNVGHIAKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMK--GGAERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRGMGSL AM K RY+
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEA-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ V +GV G V +G++ + + L+ G++ +GA+++ +++
Sbjct: 435 -DKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR 480
>gb|AAD10256.1| (AF035679) inosine-5'-monophosphate dehydrogenase [Plasmodium
falciparum]
Length = 510
Score = 264 bits (667), Expect = 2e-69
Identities = 167/470 (35%), Positives = 260/470 (54%), Gaps = 35/470 (7%)
Query: 12 IRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREG 71
+ YT+D ++ +P + D+D++ +T N+ L P++S+ MDTVT +M++A+A G
Sbjct: 14 VMSYTYDVIICMPGYIDFALSDIDLTNNMTDNITLKTPVISSPMDTVTGHKMSIALALSG 73
Query: 72 GLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVE 131
GLGVIH NMSIE+Q+E+VK+VK+ E + D T SPE TV L + P+
Sbjct: 74 GLGVIHNNMSIEKQIEEVKKVKRFENGFIFDPYTFSPEHTVADVLETKNRVGYKSYPITV 133
Query: 132 NEKV----VGIISKKDIAAREGKLVK--ELMTKDVITVPENIEVEEALKIMIENRIDRLP 185
+ KV VGII+ D K +K ++MT DV+T I + +A K++ + + LP
Sbjct: 134 DGKVGSKLVGIITGIDYLYLTNKSMKIGDIMTTDVVTGSYPINLSDANKVLCDEKKSVLP 193
Query: 186 VVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVS--PFDIRRAIELDRAGADV 243
+V+K LI L+ +D+ + + +A + +N +L+V A++S D+ RA +L + DV
Sbjct: 194 IVNKNNELIALVCRNDMHKNRIFPHASKSQNKQLIVGASISTREHDLERANQLIKNMIDV 253
Query: 244 IVVDTAHAHNLKAIKAMKEMRQ-KVDADFIVGNIANPKAVDDL--TFADAVKVGIGPGSI 300
I +D++ +++ I +K+++ D I GN+ + +L AD +++G+G GSI
Sbjct: 254 ICIDSSQGNSIYQIDTIKKIKSAHPDIPIIGGNVVTSQQAKNLIDAGADVLRIGMGSGSI 313
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTT+ V VG Q TA+ V+ A + IADGGIK SG+IVKA++ GAD VMLGNLL
Sbjct: 314 CTTQDVCAVGRAQGTAVYHVSKYAHTRNIKTIADGGIKNSGNIVKALSLGADFVMLGNLL 373
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPE-------- 412
A T+E+ + N + K YRGMGS+ AM Y +G K+R V E
Sbjct: 374 AATEESCSEYYFENNVRLKIYRGMGSMEAM-------YNKGFNSKSRYLVDERKNEYTDE 426
Query: 413 ---------GVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEK 453
GV + +G+V ++ L +K G +G RNI EL K
Sbjct: 427 NIDEIKVSQGVSASLVDKGSVLNLIPHLFKAVKHGFQSMGIRNIPELHSK 476
>gi|4504687 IMP (inosine monophosphate) dehydrogenase 1; sWSS2608 [Homo
sapiens] >gi|307067|gb|AAA36114.1| (J05272) IMP
dehydrogenase type 1 (EC 1.1.1.205) [Homo sapiens]
Length = 514
Score = 263 bits (664), Expect = 4e-69
Identities = 161/467 (34%), Positives = 266/467 (56%), Gaps = 20/467 (4%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A++L + T++D L++P + +VD+++ +T + L P++S+ MDTVTE
Sbjct: 17 GLTAQQLFASADDLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEA 76
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEK 121
+MA+AMA GG+G IH N + E Q +V++VK E+ + D + +SP TV L +
Sbjct: 77 DMAIAMALMGGIGFIHHNCTPEFQANEVRKVKNFEQGFITDPVVLSPSHTVGDVLEAKMR 136
Query: 122 HDIDGLPVVEN----EKVVGIISKKDIAAREGK----LVKELMTK--DVITVPENIEVEE 171
H G+P+ E K+VGI++ +DI K L+ E+MT +++ P + ++E
Sbjct: 137 HGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKE 196
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPF--D 229
A +I+ ++ +LP+V+ L+ +I +DL + Y A +D +LL AAV D
Sbjct: 197 ANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDD 256
Query: 230 IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDLTFA 288
R L +AG DVIV ++ +++ I + ++QK I GN+ +L A
Sbjct: 257 KYRLDLLTQAGVDVIVFHSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDA 316
Query: 289 --DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKA 346
D ++VG+G GSIC T+ V G PQ TA+ VA+ A+ +G+ +IADGGI+ G +VKA
Sbjct: 317 GVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKA 376
Query: 347 IAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGA--ERYYQGGYM 404
+A GA VM+G+LLA T EAPG+ +G + K+YRGMGSL M K + +RY+ G
Sbjct: 377 LALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDPMEKSSSSQKRYFSEG-- 434
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
+ + +GV G + +G++ + + L+ G++ G +GAR++ L+
Sbjct: 435 -DKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR 480
>pir||S59508 IMP dehydrogenase (EC 1.1.1.205) ras - fruit fly (Drosophila sp.)
>gi|1245861|gb|AAB35628.1| (S80430) inosine
monophosphate dehydrogenase, IMPD [Drosophila, Peptide,
537 aa] [Drosophila sp.]
Length = 537
Score = 257 bits (651), Expect = 1e-67
Identities = 168/473 (35%), Positives = 265/473 (55%), Gaps = 27/473 (5%)
Query: 1 MGKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE 60
+G K+L + G ++D L++P + ++VD+S+ +T ++ L P++S+ MDTVTE
Sbjct: 38 VGLSCKELFQNGEGLPYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTE 97
Query: 61 WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLME 120
AMA GG+G+IH N + E Q +V +VKK + + D +SP TV L
Sbjct: 98 -SRCHAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARR 156
Query: 121 KHDIDGLPVVENEKV----VGIISKKDIAAREGK---LVKELMTKDVITVPE--NIEVEE 171
K+ G PV EN K+ +G+++ + I RE + L+ ++MT +++T P N+ E
Sbjct: 157 KNGFTGYPVTENGKLGGKLLGMVTSRAIDFRENQPESLLADIMTTELVTAPNGINLPTEH 216
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFD-- 229
A+ +E +V++ G L+ +I +DL + Y NA +D N LL AA+
Sbjct: 217 AI---LEKSKKATAIVNQAGELVAMIARADLKKARSYPNASKDSNTRLLCPAAIGTRSED 273
Query: 230 --IRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLT 286
R L R G DVI++D++ +++ ++ +K +++ + I GN+ +L
Sbjct: 274 KGCRALALLVRNGVDVIILDSSQGNSVIQVEMIKYIKETYPELQVIGGNVVTRAQAKNLI 333
Query: 287 FA--DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIV 344
A D ++VG+G GSIC T+ V G PQ TA+ V+ A+++G+ VIADGGI G IV
Sbjct: 334 DAGVDGLRVGMGSGSICITQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIHAIGHIV 393
Query: 345 KAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAE-----RYY 399
KAIA GA AVM+G+LLAGT EAPG+ +G + K+YRGMGSL AM +G A+ RYY
Sbjct: 394 KAIALGASAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYY 453
Query: 400 QGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
K + V +GV G + +G+V L L GL+ +GA +I +L++
Sbjct: 454 HNEMDKMK--VAQGVSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRD 504
>pir||C72109 IMP dehydrogenase homolog (EC 1.-.-.-) - Chlamydophila pneumoniae
(strain CWL029) >gi|4376441|gb|AAD18325.1| (AE001604)
Inosine 5'-monophosphase dehydrogenase [Chlamydophila
pneumoniae CWL029] >gi|8978545|dbj|BAA98382.1|
(AP002545) inosine 5'-monophosphase dehydrogenase
[Chlamydophila pneumoniae J138]
Length = 246
Score = 257 bits (651), Expect = 1e-67
Identities = 136/246 (55%), Positives = 175/246 (70%), Gaps = 5/246 (2%)
Query: 239 AGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTF--ADAVKVGI 295
AGA+V+V+DTAHAH+ + + E++ + +VGN+ +A L DAVKVGI
Sbjct: 3 AGANVLVIDTAHAHSKGVFQTVLEIKSQFPQISLVVGNLVTAEAAVSLAEIGVDAVKVGI 62
Query: 296 GPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVM 355
GPGSICTTRIV+GVG PQITAI VA + + VIADG I+YSGD+VKA+AAGAD VM
Sbjct: 63 GPGSICTTRIVSGVGYPQITAITNVAKALKNSAVTVIADGRIRYSGDVVKALAAGADCVM 122
Query: 356 LGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVE 415
LG+LLAGT EAPG V I+ + +K+YRGMGSLGAM +G A+RY+Q K K VP GVE
Sbjct: 123 LGSLLAGTDEAPGDIVSIDEKLFKRYRGMGSLGAMKQGSADRYFQTQGQK--KLVPGGVE 180
Query: 416 GVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIIT 475
G+V Y+G+V +VLYQ++GG+++GMGYVGA +K+LK K FV IT +G ESH H+I
Sbjct: 181 GLVAYKGSVHDVLYQILGGIRSGMGYVGAETLKDLKTKASFVRITESGRAESHIHNIYKV 240
Query: 476 NEAPNY 481
NY
Sbjct: 241 QPTLNY 246
>gi|6323585 Imd4p [Saccharomyces cerevisiae] >gi|1708478|sp|P50094|IMH3_YEAST
PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP
DEHYDROGENASE) (IMPDH) (IMPD) >gi|1071807|pir||S50890
IMP dehydrogenase (EC 1.1.1.205) YML056c - yeast
(Saccharomyces cerevisiae) >gi|577140|emb|CAA86719.1|
(Z46729) putative inosine-5'-monophoshate dehydrogenase
[Saccharomyces cerevisiae]
Length = 524
Score = 254 bits (642), Expect = 2e-66
Identities = 154/457 (33%), Positives = 251/457 (54%), Gaps = 21/457 (4%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D L++P V + T++T + LN P +S+ MDTVTE +MA+ MA GG+
Sbjct: 37 GLTYNDFLVLPGLVNFPSSAVSLQTKLTKKITLNTPFVSSPMDTVTEADMAIYMALLGGI 96
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
G IH N + +EQ VK+VK E + I ISP TV + K G PV E+
Sbjct: 97 GFIHHNCTPKEQASMVKKVKMFENGFINSPIVISPTTTVGEVKVMKRKFGFSGFPVTEDG 156
Query: 134 K----VVGIISKKDIAAREGK--LVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
K +VG+++ +DI E +V E+MTK+ +T + I ++E +I+ + + +L +V
Sbjct: 157 KCPGKLVGLVTSRDIQFLEDDSLVVSEVMTKNPVTGIKGITLKEGNEILKQTKKGKLLIV 216
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRDENG-ELLVAAAVSPF--DIRRAIELDRAGADVI 244
D G L+ +++ +DL+ + Y A + +LL AA+ D R L AG DV+
Sbjct: 217 DDNGNLVSMLSRADLMKNQNYPLASKSATTKQLLCGAAIGTIEADKERLRLLVEAGLDVV 276
Query: 245 VVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSIC 301
++D++ +++ + +K +++ D + I GN+A + +L A D +++G+G GSIC
Sbjct: 277 ILDSSQGNSVFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSIC 336
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLA 361
T+ V G PQ TA+ V A ++G+ +ADGG++ G I KA+A G+ VM+G +LA
Sbjct: 337 ITQEVMACGRPQGTAVYNVCQFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLA 396
Query: 362 GTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGG------AERYYQGGYMKTRKFVPEGVE 415
GT E+PG+ +G++ K YRGMGS+ AM K G RY+ V +GV
Sbjct: 397 GTTESPGEYFYKDGKRLKAYRGMGSIDAMQKTGNKGNASTSRYFS---ESDSVLVAQGVS 453
Query: 416 GVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
G V +G++ + + L GL+ +G ++ LKE
Sbjct: 454 GAVVDKGSIKKFIPYLYNGLQHSCQDIGCESLTSLKE 490
>sp|Q12658|IMDH_PNECA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|1272244|gb|AAA97462.1| (U42442) IMP
dehydrogenase [Pneumocystis carinii]
Length = 454
Score = 247 bits (624), Expect = 2e-64
Identities = 162/448 (36%), Positives = 257/448 (57%), Gaps = 29/448 (6%)
Query: 51 LSAAMDTVTEWEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEE 110
+S+ MDTVTE +MA+ +A GG+GVIH N +IEEQ E V++VKK E + I +S
Sbjct: 1 MSSPMDTVTESDMAINLALLGGIGVIHHNCTIEEQTEMVRKVKKFENGFITSPIVLSLNH 60
Query: 111 TVDFALFLMEKHDIDGLPVVE----NEKVVGIISKKDIAAREG--KLVKELMTKDVITVP 164
V + E+ G+P+ + N K++GI++ +DI + E++TKD++T
Sbjct: 61 RVRDVRRIKEELGFSGIPITDTGQLNGKLLGIVTSRDIQFHNNDESFLSEVITKDLVTGS 120
Query: 165 ENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVR-DENGELLVAA 223
E I +EEA +I+ + +LP+VDKEG L L++ SDL+ + A + ++ +L+ A
Sbjct: 121 EGIRLEEANEILRSCKKGKLPIVDKEGNLTALLSRSDLMKNLHFPLASKLPDSKQLICAQ 180
Query: 224 AVS--PFDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPK 280
AV P D R L AG D++V+D++ +++ I +K +++ + + I GN+ +
Sbjct: 181 AVGTRPDDRIRLKHLVEAGLDIVVLDSSQGNSIYQINMIKWNKKEFPNLEVIAGNVVTRE 240
Query: 281 AVDDLTFA--DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIK 338
+L A DA++VG+G GSIC T+ + VG PQ TA+ V++ A ++G+ IADGGI+
Sbjct: 241 QAANLISAGADALRVGMGSGSICITQEIMAVGRPQATAVYAVSEFASKFGVPTIADGGIE 300
Query: 339 YSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMM------- 391
G I KA+A GA AVM+GNLLAGT E+PG+ +G++ K YRGMGS+ AM
Sbjct: 301 NIGHITKALALGASAVMMGNLLAGTTESPGQYYYRDGQRLKSYRGMGSIDAMEHLSGKNK 360
Query: 392 --KGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNI-- 447
+ RY+ G T + V +GV G V +G++ + L GL+ + +G +N+
Sbjct: 361 GDNAASSRYF--GEADTIR-VAQGVSGSVIDKGSLHVYVPYLRTGLQHSLQDIGVQNLTE 417
Query: 448 --KELKEKG-EFVIITSAGLRESHPHDI 472
K++KEK F T A E + H +
Sbjct: 418 LRKQVKEKNIRFEFRTVASQLEGNVHGL 445
>pir||A38668 IMP dehydrogenase (EC 1.1.1.205) - Leishmania donovani
Length = 514
Score = 246 bits (622), Expect = 4e-64
Identities = 155/455 (34%), Positives = 250/455 (54%), Gaps = 18/455 (3%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D +++P + DV++S Q T ++L+IPI+S+ MDT+TE EMA MA GG+
Sbjct: 27 GLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHIPIVSSPMDTITENEMAKTMALMGGV 86
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
GV+H N ++E QVE VK VK + ++ P + + + E+ I G+ V EN
Sbjct: 87 GVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPPNTPISNIIRIKEEKGISGILVTENG 146
Query: 134 ----KVVGIISKKDIAAREGK--LVKELMTK-DVITVPEN-IEVEEALKIMIENRIDRLP 185
K++GI+ KDI + K V +MT+ + +TV I++EEA+ ++ +R LP
Sbjct: 147 DPHGKLLGIVCTKDIDYVKNKDTPVSAVMTRREKMTVERAPIQLEEAMDVLNRSRYGYLP 206
Query: 186 VVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVS--PFDIRRAIELDRAGADV 243
+V++ ++ L + D V + Y ++ D++G L+ AAA S P D RR L G DV
Sbjct: 207 IVNENDEVVNLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRPEDKRRVAALADVGVDV 266
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDL--TFADAVKVGIGPGSI 300
+V+D++ + + I +K ++ + + GN+ +L AD +++G+G GSI
Sbjct: 267 LVLDSSQGNTIYQIAFIKWVKSTYPHLEVVAGNVVTQDQAKNLIDAEADGIRIGMGSGSI 326
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
C T+ V G PQ TA+ VA G+ ADGG++ GDI KA+A GA+ MLG +L
Sbjct: 327 CITQEVLACGRPQGTAVYKVAQYCASRGVPCTADGGLRQVGDICKALAIGANCAMLGGML 386
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKG--GAERYYQGGYMKTRKFVPEGVEGVV 418
+GT E PG+ G + K YRGMGSL AM +G +RY V +GV G V
Sbjct: 387 SGTTETPGEYFFKGGVRLKVYRGMGSLEAMSQGKESGKRYLSENEAVQ---VAQGVSGNV 443
Query: 419 PYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEK 453
+G+ ++++ + GL+ +G + ++EK
Sbjct: 444 VDKGSAAKLIAYVSKGLQQSAQDIGEISFDAIREK 478
>sp|P21620|IMDH_LEIDO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|159361|gb|AAA29253.1| (M55667) IMP
dehydrogenase [Leishmania donovani]
Length = 514
Score = 246 bits (622), Expect = 4e-64
Identities = 155/455 (34%), Positives = 250/455 (54%), Gaps = 18/455 (3%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D +++P + DV++S Q T ++L+IPI+S+ MDT+TE EMA MA GG+
Sbjct: 27 GLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHIPIVSSPMDTITENEMAKTMALMGGV 86
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
GV+H N ++E QVE VK VK + ++ P + + + E+ I G+ V EN
Sbjct: 87 GVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPPNTPISNIIRIKEEKGISGILVTENG 146
Query: 134 ----KVVGIISKKDIAAREGK--LVKELMTK-DVITVPEN-IEVEEALKIMIENRIDRLP 185
K++GI+ KDI + K V +MT+ + +TV I++EEA+ ++ +R LP
Sbjct: 147 DPHGKLLGIVCTKDIDYVKNKDTPVSAVMTRREKMTVERAPIQLEEAMDVLNRSRYGYLP 206
Query: 186 VVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVS--PFDIRRAIELDRAGADV 243
+V++ ++ L + D V + Y ++ D++G L+ AAA S P D RR L G DV
Sbjct: 207 IVNENDEVVNLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRPEDKRRVAALADVGVDV 266
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDL--TFADAVKVGIGPGSI 300
+V+D++ + + I +K ++ + + GN+ +L AD +++G+G GSI
Sbjct: 267 LVLDSSQGNTIYQIAFIKWVKSTYPHLEVVAGNVVTQDQAKNLIDAGADGIRIGMGSGSI 326
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
C T+ V G PQ TA+ VA G+ ADGG++ GDI KA+A GA+ MLG +L
Sbjct: 327 CITQEVLACGRPQGTAVYKVAQYCASRGVPCTADGGLRQVGDICKALAIGANCAMLGGML 386
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKG--GAERYYQGGYMKTRKFVPEGVEGVV 418
+GT E PG+ G + K YRGMGSL AM +G +RY V +GV G V
Sbjct: 387 SGTTETPGEYFFKGGVRLKVYRGMGSLEAMSQGKESGKRYLSENEAVQ---VAQGVSGNV 443
Query: 419 PYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEK 453
+G+ ++++ + GL+ +G + ++EK
Sbjct: 444 VDKGSAAKLIAYVSKGLQQSAQDIGEISFDAIREK 478
>sp|P50098|IMDH_TRYBB INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|1078708|pir||A55407 IMP dehydrogenase (EC
1.1.1.205) - Trypanosoma brucei brucei
>gi|162136|gb|AAB46420.1| (M97794)
inosine-5'-monophosphate dehydrogenase [Trypanosoma
brucei]
Length = 512
Score = 241 bits (609), Expect = 1e-62
Identities = 153/455 (33%), Positives = 249/455 (54%), Gaps = 18/455 (3%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G +F+D +++P + + V+VS Q T N+ L++P++S+ MDTVTE MA AMA GG+
Sbjct: 25 GLSFNDFIILPGFIDFDSSKVNVSGQFTKNILLHLPLVSSPMDTVTESSMARAMALMGGI 84
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVE-- 131
GVIH N ++E+Q V+ VK + ++SP+ V + + I G+ V E
Sbjct: 85 GVIHNNCTVEQQARMVRSVKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGG 144
Query: 132 --NEKVVGIISKKDI--AAREGKLVKELMTKDVITVPEN--IEVEEALKIMIENRIDRLP 185
+ K++GI+ KDI V + MT+ E I++EEA+ ++ +R LP
Sbjct: 145 KYDGKLLGIVCTKDIDFVKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHGYLP 204
Query: 186 VVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSP--FDIRRAIELDRAGADV 243
V++ + ++ L + D V + Y N+ D NG LL AAA S D R L AG DV
Sbjct: 205 VLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADKGRVAALSEAGIDV 264
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVD-ADFIVGNIANPKAVDDL--TFADAVKVGIGPGSI 300
+V+D++ + + + ++ +++ + + GN+ +L AD++++G+G GSI
Sbjct: 265 LVLDSSQGNTIYQVSFIRWVKKTYPHLEVVAGNVVTQDQAKNLIDAGADSLRIGMGSGSI 324
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
C T+ V G PQ TAI VA A G+ +ADGG++ GD+ KA+A GA+ MLG+++
Sbjct: 325 CITQEVLACGRPQATAIYKVARYAASRGVPCVADGGLRNVGDVCKALAVGANVAMLGSMI 384
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKG--GAERYYQGGYMKTRKFVPEGVEGVV 418
AGT E PG+ +G + K YRGMGS+ AM++G +RY V +GV G V
Sbjct: 385 AGTSETPGEYFFKDGMRLKGYRGMGSIDAMLQGRESGKRYLSENETLQ---VAQGVAGAV 441
Query: 419 PYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEK 453
+G+V ++L + GL+ +G + ++EK
Sbjct: 442 LDKGSVLKLLAYIHKGLQQSAQDIGEVSFDAIREK 476
>emb|CAB76883.1| (AL159139) putative inosine monophosphate dehydrogenase
[Streptomyces coelicolor A3(2)]
Length = 483
Score = 232 bits (585), Expect = 8e-60
Identities = 161/468 (34%), Positives = 257/468 (54%), Gaps = 21/468 (4%)
Query: 16 TFDDVLLIPQATEVEPKD-VDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLG 74
T+DDV ++P + V + VD+ + IP++ A M + MA +AR GGL
Sbjct: 17 TYDDVFMVPSRSAVGSRQGVDLGSP--DGTGTTIPLVVANMTAIAGRRMAETVARRGGLV 74
Query: 75 VIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDID-GLPVVENE 133
VI +++ IE + V VK + +++ I ++P +TV AL L+ K + G+ V E+
Sbjct: 75 VIPQDIPIEVVTDVVSWVK-SRHHVLDTPIVLAPHQTVADALALLPKRAHNAGVVVDEDG 133
Query: 134 KVVGIISKKDIAAREG-KLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGR 192
K VG+++ D+ + ++E+M+KD+I + +++ EA + P VDK+GR
Sbjct: 134 KPVGVVTDTDLNGVDRFTQLEEVMSKDLILIDADLDPREAFNTLDAANRRYAPAVDKDGR 193
Query: 193 LIGLITMSDLVARKKYKNAVRDENGELLVAAAVS-PFDIR-RAIELDRAGADVIVVDTAH 250
L G++T + Y AV D G L +AAAV D+ +A +L AG D +V+DTAH
Sbjct: 194 LAGILTRKGALRATLYTPAV-DAQGRLRIAAAVGINGDVAGKAKQLLDAGVDTLVIDTAH 252
Query: 251 AHNLKAIKAMKEMRQ-KVDADFIVGNIANPKAVDDL--TFADAVKVGIGPGSICTTRIVA 307
H I A+K +R + GNI + + V DL AD +KVG+GPG++CTTR++
Sbjct: 253 GHQESMISAVKVVRDLDPRVPIVAGNIVSAQGVRDLIEAGADIIKVGVGPGAMCTTRMMT 312
Query: 308 GVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAP 367
GVG PQ +A+ A A++YG +V ADGG+++ D+ A+AAGA VM+G+ AGT E+P
Sbjct: 313 GVGRPQFSAVLECAAEAKKYGKHVWADGGVRHPRDVAMALAAGASNVMVGSWFAGTYESP 372
Query: 368 GK-EVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRK-FVPEGVEG----VVPYR 421
G + NGR YK+ GM S A+ +E + Y + RK EG+ + P R
Sbjct: 373 GDLQHDANGRAYKESFGMASARAVRNRTSE---ESAYDRARKALFEEGISTSRMFLDPAR 429
Query: 422 GTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHP 469
V +++ ++ G+++ Y GA +++E EK I ++AG E P
Sbjct: 430 PGVEDLIDAIIAGVRSSCTYAGAGSLEEFTEKAIVGIQSAAGYAEGKP 477
>gb|AAD34687.1|AC006341_15 (AC006341) Strong similarity to gb|L34684 inosine monophosphate
dehydrogenase (IMPDH) from Arabidopsis thaliana and is a
member of the PF|00478 IMP dehydrogenase family
Length = 502
Score = 228 bits (574), Expect = 2e-58
Identities = 156/475 (32%), Positives = 260/475 (53%), Gaps = 36/475 (7%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A+KL YT+DDV+ +P + V +ST+++ V L+IP +++ MDTV+E
Sbjct: 7 GFSAEKLFSQGYSYTYDDVIFLPHFIDFSTDAVSLSTRLSKRVPLSIPCVASPMDTVSES 66
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETV----DFA-- 115
MA AMA GG+G++H N I+ Q ++ K + I D + PE + DF
Sbjct: 67 HMAAAMAALGGIGIVHYNCDIDTQASVIRHAKSLQVPIASDAVFKCPEHQIGSVDDFGPS 126
Query: 116 --LFLMEKHDIDGLPVVENEKVVGIISKKDIAA-----REGKL---VKELMTKDVITVPE 165
+F+ + + K++G +SK + ++ +E K+ +K KD VP
Sbjct: 127 SFVFVSQTGTL-------TPKLLGYVSKSEWSSMKDDQKEVKIYDYMKSCENKDYY-VPW 178
Query: 166 NIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENG---ELLVA 222
+I++++ ++ ++E++ V++KEG + ++T D+ K Y G + +V
Sbjct: 179 DIDLDK-IEAVLEDKQKGFVVLEKEGETVNVVTKDDVERVKGYPKLGSGTVGADKKWMVG 237
Query: 223 AAVSP--FDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANP 279
AA+ D R L +AGA+V+V+D++ +++ ++ +K ++ + D + GN+
Sbjct: 238 AAIGTRESDKERLEHLVKAGANVVVLDSSQGNSIYQLEMIKYVKNTYPELDVVGGNVVTM 297
Query: 280 KAVDDLTFA--DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGI 337
++L A D ++VG+G GSICTT+ V VG Q TA+ V+ A ++G+ VIADGGI
Sbjct: 298 YQAENLIKAGVDGLRVGMGSGSICTTQEVCAVGRGQATAVYKVSTLAAQHGVPVIADGGI 357
Query: 338 KYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAER 397
SG IVKA+ GA VM+G+ LAG+ EAPG NGR+ K+YRGMGSL AM KG +R
Sbjct: 358 SNSGHIVKALVLGASTVMMGSFLAGSTEAPGAYEYRNGRRVKKYRGMGSLEAMTKGSDQR 417
Query: 398 YYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
Y G K + + +GV G V +G+V + + + +K G +GA +++ E
Sbjct: 418 YL-GDTAKLK--IAQGVVGAVADKGSVLKFIPYTMHAVKQGFQDLGASSLQSAHE 469
>dbj|BAA90835.1| (AB031209) GuaB [Bacillus halodurans]
Length = 281
Score = 226 bits (571), Expect = 3e-58
Identities = 123/272 (45%), Positives = 190/272 (69%), Gaps = 9/272 (3%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G TFDDVLL+P +EV P+DV V T++T ++LNIPI+SA MDTVTE +MA+A+AREGGL
Sbjct: 10 GLTFDDVLLVPAKSEVLPRDVSVKTKLTETLQLNIPIISAGMDTVTEAKMAIAIAREGGL 69
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV-EN 132
G+IH+NMS+EEQ EQV RVK++E ++ + ++P+ V A LM K+ I G+P+V E+
Sbjct: 70 GIIHKNMSVEEQAEQVDRVKRSESGVITNPFFLTPDRQVFDAEHLMGKYRISGVPIVDED 129
Query: 133 EKVVGIISKKDIAARE--GKLVKELMTKD-VITVPENIEVEEALKIMIENRIDRLPVVDK 189
+K+VGI++ +D+ E L+ ++MTK+ ++T P ++EA +I+ +++I++LP+VD+
Sbjct: 130 QKLVGILTNRDLRFIEDYSTLIDDVMTKENLVTAPVGTTLKEAEEILQKHKIEKLPLVDE 189
Query: 190 EGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV---SPFDIRRAIELDRAGADVIVV 246
G L GLIT+ D+ ++ N+ +D G L+V AAV + D+R A L AG DVIV+
Sbjct: 190 SGTLKGLITIKDIEKVIEFPNSAKDSQGRLIVGAAVGVSADTDVRVA-ALVEAGVDVIVI 248
Query: 247 DTAHAHNLKAIKAMKEMRQKV-DADFIVGNIA 277
DTAH H+ ++ +K +R++ D I GN+A
Sbjct: 249 DTAHGHSKGVLEKVKAIREQYPDLTIIAGNVA 280
>sp|P47996|IMDH_ARATH INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|2117507|pir||JC4999 IMP dehydrogenase (EC
1.1.1.205) - Arabidopsis thaliana
>gi|1100063|gb|AAB41940.1| (L34684) IMP dehydrogenase
[Arabidopsis thaliana]
>gi|4835762|gb|AAD30229.1|AC007202_11 (AC007202)
Identical to gb|L34684 IMP dehydrogenase (IMPDH) from
Arabidopsis thaliana
Length = 503
Score = 219 bits (552), Expect = 6e-56
Identities = 149/461 (32%), Positives = 245/461 (52%), Gaps = 21/461 (4%)
Query: 5 AKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMA 64
A KL YT+DDV+ +P + V +ST+++ V L+IP +S+ MDTV+E MA
Sbjct: 10 ADKLFAQGYSYTYDDVIFLPHFIDFSTDAVSLSTRLSRRVPLSIPCVSSPMDTVSESHMA 69
Query: 65 VAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPE-ETVDFALFLMEKHD 123
AMA GG+G++H N I Q +++ K + I D PE E F
Sbjct: 70 AAMASLGGIGIVHYNCGIAAQASIIRQAKSLKHPIASDAGVKFPEYEITSLDAFGPSSFV 129
Query: 124 -IDGLPVVENEKVVGIISKK-----DIAAREGKLVKELMTKDV--ITVPENIEVEEALKI 175
++ + K++G ++K + RE K+ + + D VP I+ E+ L+
Sbjct: 130 FVEQTGTMTTPKLLGYVTKSQWKRMNYEQREMKIYDYMKSCDSSDYCVPWEIDFEK-LEF 188
Query: 176 MIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNA---VRDENGELLVAAAVSP--FDI 230
++E++ V++++G + ++T D+ K Y + +GE +V AA+ D
Sbjct: 189 VLEDKQKGFVVLERDGETVNVVTKDDIQRVKGYPKSGPGTVGPDGEWMVGAAIGTRESDK 248
Query: 231 RRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLTFA- 288
R L G + +V+D++ +++ ++ +K +++ + D I GN+ +L A
Sbjct: 249 ERLEHLVNVGVNAVVLDSSQGNSIYQLEMIKYVKKTYPELDVIGGNVVTMYQAQNLIQAG 308
Query: 289 -DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAI 347
D ++VG+G GSICTT+ V VG Q TA+ V A + G+ VIADGGI SG IVKA+
Sbjct: 309 VDGLRVGMGSGSICTTQEVCAVGRGQATAVYKVCSIAAQSGIPVIADGGISNSGHIVKAL 368
Query: 348 AAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTR 407
GA VM+G+ LAG+ EAPG NG++ K+YRGMGSL AM KG +RY +T+
Sbjct: 369 VLGASTVMMGSFLAGSTEAPGGYEYTNGKRIKKYRGMGSLEAMTKGSDQRYLGD---QTK 425
Query: 408 KFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIK 448
+ +GV G V +G+V +++ + +K G +GA +++
Sbjct: 426 LKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASSLQ 466
>sp|Q50591|YI43_MYCTU HYPOTHETICAL 50.0 KDA PROTEIN RV1843C >gi|7431404|pir||C70664 IMP
dehydrogenase (EC 1.1.1.205) guaB1 [similarity] -
Mycobacterium tuberculosis (strain H37RV)
>gi|1781204|emb|CAB06111.1| (Z83859) guaB1
[Mycobacterium tuberculosis]
Length = 479
Score = 213 bits (538), Expect = 3e-54
Identities = 145/468 (30%), Positives = 250/468 (52%), Gaps = 22/468 (4%)
Query: 16 TFDDVLLIPQATEVEPK-DVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLG 74
T++DV ++P +EV + DVD+ST IP++ A M V MA +AR GG+
Sbjct: 15 TYNDVFIVPNRSEVASRFDVDLST--ADGSGTTIPVVVANMTAVAGRRMAETVARRGGIV 72
Query: 75 VIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEK 134
++ +++ I V+Q K+ +++ +T++P+++V A+ L+ K V+ +
Sbjct: 73 ILPQDLPIPA-VKQTVAFVKSRDLVLDTPVTLAPDDSVSDAMALIHKRAHGVAVVILEGR 131
Query: 135 VVGIISKKD-IAAREGKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRL 193
+G++ + + V+++ D +T P E + ++ +D + D +G L
Sbjct: 132 PIGLVRESSCLGVDRFTRVRDIAVTDYVTAPAGTEPRKIFDLLEHAPVDVAVLTDADGTL 191
Query: 194 IGLITMSDLVARKKYKNAVRDENGELLVAAAVS-PFDI-RRAIELDRAGADVIVVDTAHA 251
G+++ + + Y A D G L + AAV D+ +A L AG DV+V+DTAH
Sbjct: 192 AGVLSRTGAIRAGIYTPAT-DSAGRLRIGAAVGINGDVGAKARALAEAGVDVLVIDTAHG 250
Query: 252 HNLKAIKAMKEMRQ-KVDADFIVGNIANPKAVDDLTFADA--VKVGIGPGSICTTRIVAG 308
H +K + A+K + + GN+ + + DL A A VKVG+GPG++CTTR++ G
Sbjct: 251 HQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVGPGAMCTTRMMTG 310
Query: 309 VGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPG 368
VG PQ +A+ A A++ G ++ ADGGI++ D+ A+AAGA VM+G+ AGT E+PG
Sbjct: 311 VGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALALAAGASNVMIGSWFAGTYESPG 370
Query: 369 KEV-IINGRKYKQYRGMGSLGAMM-KGGAERYYQGGYMKTRK-FVPEGVE----GVVPYR 421
+ + + YK+ GM S A++ + GA+ + + RK EG+ G+ P R
Sbjct: 371 DLMRDRDDQPYKESYGMASKRAVVARTGADNPFD----RARKALFEEGISTSRMGLDPDR 426
Query: 422 GTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHP 469
G V +++ + G+++ YVGA N+ EL E+ + + AG E HP
Sbjct: 427 GGVEDLIDHITSGVRSTCTYVGASNLAELHERAVVGVQSGAGFAEGHP 474
>pir||T32709 IMP dehydrogenase (EC 1.1.1.205) T22D1.3 - Caenorhabditis elegans
>gi|9798164|gb|AAF98635.1| (AF039052) Contains
similarity to Pfam domain: PF00478 (IMPDH), Score=294.9,
E-value=3.3e-85, N=1 [Caenorhabditis elegans]
Length = 499
Score = 212 bits (533), Expect = 1e-53
Identities = 147/463 (31%), Positives = 249/463 (53%), Gaps = 49/463 (10%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G T++D ++P DV + T IT ++K+ P++S+ MDTVTE MA+ MA GG+
Sbjct: 31 GLTYNDFNILPGFINFGVHDVSLETNITKDLKIKAPLVSSPMDTVTESGMAIVMALYGGI 90
Query: 74 GVIHRNM-SIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN 132
G+IH N E+Q +V +VK+ ++ V +S + T + + +K+ G PV E+
Sbjct: 91 GIIHGNFPKPEDQAAEVLKVKRFKQGYVMQPHCLSRDSTAFDMIQIKKKYGYTGAPVTED 150
Query: 133 ----EKVVGIISKKD-------IAAREGKLVKELMTK-DVITVPE-NIEVEEALKIMIEN 179
K++G+++ +D +A ++G + ++M D + + N E + K + E+
Sbjct: 151 GRVGSKLIGMVTSRDFDFITMDVAGQKGTPISDIMVSVDQLHLGHINDAPELSQKKLKEH 210
Query: 180 RIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAV-----SPFDIRRAI 234
R+ +LP+V+ G L L+ SDL+ + Y A D G+LL AAV S + + R +
Sbjct: 211 RLGKLPIVNDNGELCALLCRSDLLKARDYPMASYDSKGQLLCGAAVNTRGESQYTVDRVV 270
Query: 235 ELDRAGADVIVVDTAHAHNLKAIKAMKEMRQK-VDADFIVGNI---ANPKAVDDLTFADA 290
E AG DV+++D+++ + I ++ +++K I GN+ A K + D AD
Sbjct: 271 E---AGVDVLIIDSSNGSSTYQISMLRYIKEKHPHVQVIAGNVVTRAQAKLLIDQG-ADG 326
Query: 291 VKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAG 350
+++G+G GSIC T+ V VG Q TA+ VA A + G+ ++ADGGI+ G I KAI+ G
Sbjct: 327 LRIGMGSGSICITQDVMAVGRAQGTAVYDVARYANQRGIPIVADGGIRDVGYITKAISLG 386
Query: 351 ADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFV 410
A AVM+G LLA T EAPG + + G GG+ + + +K V
Sbjct: 387 ASAVMMGGLLAATTEAPG----------EYFWG--------PGGSFNFSESDQIK----V 424
Query: 411 PEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEK 453
+GV + RG+ + + L+ G++ GM +G R++++ +EK
Sbjct: 425 AQGVSATMKDRGSCHKFIPYLIRGVQHGMQDIGVRSLRDFREK 467
>emb|CAB38030.1| (AJ010201) inosine monophosphate dehydrogenase [Glycine max]
Length = 502
Score = 208 bits (524), Expect = 1e-52
Identities = 150/464 (32%), Positives = 247/464 (52%), Gaps = 26/464 (5%)
Query: 2 GKFAKKLERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEW 61
G A+KL YT+DDV+ +P + VD+ST++T + L +P +++ MDTV+E
Sbjct: 11 GFTAEKLFTQGFSYTYDDVIFLPHYIDFAADAVDLSTRLTRRLPLAVPFVASPMDTVSES 70
Query: 62 EMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDF------A 115
MA AMA GG+ V+H N+ Q ++R K I+ D +P V+ +
Sbjct: 71 AMAAAMASLGGIAVVHSNVPAAVQAAILRRAKSRRVPILSDPAFAAPSAVVEHDDAFGAS 130
Query: 116 LFLMEKHDIDGLPVVENEKVVGIISKKDIAAR--EGKLVKELMTKDVITVPENIEVEEAL 173
FL+ G V K++G +++ D + +G V + M P N ++ +
Sbjct: 131 PFLLVTDT--GTSV---GKLLGYVARSDWTNQTDKGLRVGDYMAPPPKPAPWNADLNKIN 185
Query: 174 KIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDE----NGELLVAAAVSPF- 228
+IM E+ ++++G ++ L+ ++ + Y V +GE +V AAV
Sbjct: 186 EIM-ESEKSGAVALERDGEVVDLVVREEVERVRGYPKLVAPATVGADGEFMVGAAVGTRE 244
Query: 229 -DIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDLT 286
D R L +AG +V+V+D++ +++ ++ + +++ + D I GN+ ++L
Sbjct: 245 DDKERLEHLVKAGLNVVVLDSSQGNSIYQLEMVNYVKRVYPELDVIGGNVVTMYQAENLI 304
Query: 287 FA--DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIV 344
A D ++VG+G GSICTT+ V VG Q TA+ V+ A + G+ VIADGGI SG IV
Sbjct: 305 QAGVDGLRVGMGSGSICTTQEVCAVGRGQATAVYNVSLIAYKSGVPVIADGGISNSGHIV 364
Query: 345 KAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYM 404
KA++ GA VM+G+ LAG+ EAPG V NG++ K+YRGMGSL AM KG RY G
Sbjct: 365 KALSLGASTVMMGSFLAGSLEAPGAYVYQNGQRVKKYRGMGSLEAMTKGSDARYL-GDTA 423
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIK 448
K + + +GV G V +G+V + + ++ G +GA +++
Sbjct: 424 KLK--IAQGVVGAVKDKGSVLNFIPYTLQAVRQGFQDIGASSLQ 465
>pir||T44751 IMP dehydrogenase (EC 1.1.1.205) guaB1 [similarity] - Mycobacterium
leprae >gi|2578376|emb|CAA15452.1| (AL008609)
inosine-5'-monophosphate dehydrogenase [Mycobacterium
leprae]
Length = 478
Score = 206 bits (520), Expect = 3e-52
Identities = 145/468 (30%), Positives = 248/468 (52%), Gaps = 22/468 (4%)
Query: 16 TFDDVLLIPQATEVEPK-DVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLG 74
T+ DV ++P ++V + DVD+ST IP++ A M TV MA +AR GGL
Sbjct: 14 TYKDVFIVPHRSDVASRFDVDLSTYDGSGT--TIPVVVANMTTVAGQRMAETVARRGGLV 71
Query: 75 VIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE- 133
++ +++ I V+Q K+ +++ + ++P ++V A L+ K G+ VV E
Sbjct: 72 ILPQDLPIAT-VQQAVEFVKSRDLVIDTPVLLTPNDSVSDATTLIHKR-AHGVAVVAFEG 129
Query: 134 KVVGIISKKD-IAAREGKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGR 192
+ +G++ + + V+++ T D +T P + + ++ ID + + +G
Sbjct: 130 RPIGLVRESSCLGVDRFTRVRDVATTDFVTAPVGTDPRKIFDLLEHAPIDVAVLTNADGT 189
Query: 193 LIGLITMSDLVARKKYKNAVRDENGELLVAAAVS-PFDIR-RAIELDRAGADVIVVDTAH 250
L G++T + + Y A D G L + AAV D+ +A L AG DV+VVDTAH
Sbjct: 190 LAGVLTRTGAIRAGIYTPAT-DARGRLRIGAAVGINGDVAGKAQSLAEAGVDVLVVDTAH 248
Query: 251 AHNLKAIKAMKEMRQ-KVDADFIVGNIANPKAVDDLTFADA--VKVGIGPGSICTTRIVA 307
+ +K ++A+K + + + GN+ + + +L A A VKVG+GPG++CTTR++
Sbjct: 249 GYQVKTLEAIKCVASLNLGVPLVAGNVVSAEGTRELLNAGATIVKVGVGPGAMCTTRMMT 308
Query: 308 GVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAP 367
GVG PQ +A+ A A++ +V ADGG+++ D+ A+AAGA VM+G+ AGT E+P
Sbjct: 309 GVGRPQFSAVLECASAARKLNRHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESP 368
Query: 368 GKEV-IINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRK-FVPEGVE----GVVPYR 421
G + + + YK+ GM S A++ A + + RK EG+ G+ P
Sbjct: 369 GDLMRDRHDQPYKESYGMASKRAVV---ARTVADSSFDRARKALFDEGISTSRMGLDPDH 425
Query: 422 GTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHP 469
G V +++ + G+++ YVGA + EL EK + ++AG E HP
Sbjct: 426 GGVEDLIDHITSGVRSTCTYVGASTLAELHEKAVVGVQSAAGFAEGHP 473
>sp|P50097|IMDH_TRIFO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
(IMPD) >gi|7427691|pir||A58910 IMP dehydrogenase (EC
1.1.1.205) [validated] - Tritrichomonas foetus
>gi|2554679|pdb|1AK5| Inosine Monophosphate
Dehydrogenase (Impdh) From Tritrichomonas Foetus
>gi|1352865|gb|AAB01581.1| (L18917) inosine
monophosphate dehydrogenase [Tritrichomonas foetus]
Length = 503
Score = 204 bits (513), Expect = 2e-51
Identities = 155/497 (31%), Positives = 260/497 (52%), Gaps = 36/497 (7%)
Query: 15 YTFDDVLLIPQATEVE--PKDVDVSTQITP-------NVKLNIPILSAAMDTVTEWEMAV 65
+TF++ LLIP + V+ P +V++ST + + L IP++SA M +V+ +MA+
Sbjct: 10 HTFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQKGQQSEINLKIPLVSAIMQSVSGEKMAI 69
Query: 66 AMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDID 125
A+AREGG+ I + SIE Q V VK + V + P++T L + ++ +
Sbjct: 70 ALAREGGISFIFGSQSIESQAAMVHAVKNFKAGFVVSDSNVKPDQTFADVLAISQRTTHN 129
Query: 126 GLPVVENEK----VVGIISKK----DIAAREGKLVKELMT--KDVITVPENIEVEEALKI 175
+ V ++ ++G+++++ D+ E K V ++MT ++T ++ ++ EA KI
Sbjct: 130 TVAVTDDGTPHGVLLGLVTQRDYPIDLTQTETK-VSDMMTPFSKLVTAHQDTKLSEANKI 188
Query: 176 MIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIR-RAI 234
+ E +++ LP++D + L ++ D + N + D LV A ++ D R R
Sbjct: 189 IWEKKLNALPIIDDDQHLRYIVFRKDYDRSQVCHNELVDSQKRYLVGAGINTRDFRERVP 248
Query: 235 ELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIV--GNIANPKAVDDL--TFADA 290
L AGADV+ +D++ + + +R+K V GNI + + L AD
Sbjct: 249 ALVEAGADVLCIDSSDGFSEWQKITIGWIREKYGDKVKVGAGNIVDGEGFRYLADAGADF 308
Query: 291 VKVGIGPGSICTTRIVAGVGVPQITA-IAMVADR---AQEYGLY--VIADGGIKYSGDIV 344
+K+GIG GSIC TR G+G Q TA I +VA+R +E G+Y V +DGGI Y +
Sbjct: 309 IKIGIGGGSICITREQKGIGRGQATAVIDVVAERNKYFEETGIYIPVCSDGGIVYDYHMT 368
Query: 345 KAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYM 404
A+A GAD +MLG A +E+P ++V ING K+Y G GS A +RY GG
Sbjct: 369 LALAMGADFIMLGRYFARFEESPTRKVTINGSVMKEYWGEGSSRAR---NWQRYDLGG-- 423
Query: 405 KTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGL 464
K + EGV+ VPY G + + + + +K+ M GA I +L+ K + +++S +
Sbjct: 424 KQKLSFEEGVDSYVPYAGKLKDNVEASLNKVKSTMCNCGALTIPQLQSKAKITLVSSVSI 483
Query: 465 RESHPHDIIITNEAPNY 481
E HD+I+ + +Y
Sbjct: 484 VEGGAHDVIVKDRINDY 500
>gi|6319352 Imd1p [Saccharomyces cerevisiae] >gi|731323|sp|P39567|IMH4_YEAST
PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP
DEHYDROGENASE) (IMPDH) (IMPD) >gi|1078491|pir||S53477
IMP dehydrogenase (EC 1.1.1.205) FUN63 - yeast
(Saccharomyces cerevisiae) >gi|456156|gb|AAC09509.1|
(L28920) Yar073wp [Saccharomyces cerevisiae]
Length = 403
Score = 198 bits (497), Expect = 2e-49
Identities = 117/337 (34%), Positives = 197/337 (57%), Gaps = 12/337 (3%)
Query: 14 GYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL 73
G ++D L++P + +V + T++T N+ LNIP++S+ MDTVTE EMA MA G+
Sbjct: 36 GLAYNDFLILPGLVDFASSEVSLQTKLTRNITLNIPLVSSPMDTVTESEMATFMALLDGI 95
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVV--- 130
G IH N + E+Q + V+RVK E + + I ISP TV A + EK+ G PV
Sbjct: 96 GFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKEKYGFAGFPVTADG 155
Query: 131 -ENEKVVGIISKKDIAAREGK--LVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVV 187
N K+VG I+ +DI E LV+++MTK+ +T + I + E +I+ + + RL VV
Sbjct: 156 KRNAKLVGAITSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGRLLVV 215
Query: 188 DKEGRLIGLITMSDLVARKKYKNAVRDEN-GELLVAAAVSPFDI--RRAIELDRAGADVI 244
D++G L+ +++ +DL+ +KY A + N +LL A++ D R L +AG DV+
Sbjct: 216 DEKGNLVSMLSRTDLMKNQKYPLASKSANTKQLLWGASIGTMDADKERLRLLVKAGLDVV 275
Query: 245 VVDTAHAHNLKAIKAMKEMRQKV-DADFIVGNIANPKAVDDL--TFADAVKVGIGPGSIC 301
++D++ +++ + +K +++ D + I GN+ + +L AD +++G+G GSIC
Sbjct: 276 ILDSSQGNSIFQLNMIKWIKETFPDLEIIAGNVVTKEQAANLIAAGADGLRIGMGTGSIC 335
Query: 302 TTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIK 338
T+ V G PQ TA+ V + A ++G+ +ADGG++
Sbjct: 336 ITQKVMACGRPQGTAVYNVCEFANQFGVPCMADGGVQ 372
>sp|P27442|GUAC_ASCSU GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE)
(GUANOSINE MONOPHOSPHATE REDUCTASE)
>gi|159661|gb|AAA29373.1| (M82838) GMP reductase
[Ascaris lumbricoides]
Length = 356
Score = 153 bits (384), Expect = 3e-36
Identities = 92/240 (38%), Positives = 136/240 (56%), Gaps = 11/240 (4%)
Query: 224 AVSPFDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDADFI-VGNIANPKAV 282
+ S FD R + + I +D A+ ++ + ++ +R++ I GN+ + V
Sbjct: 109 STSDFDKLRTVCDMIPELEYICLDVANGYSEVFVDFIRRVREQFPTHTIFAGNVVTGEMV 168
Query: 283 DDLTF--ADAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYS 340
++L AD VKVGIGPGS+CTTR AGVG PQ++A+ AD + +V++DGG
Sbjct: 169 EELILSGADVVKVGIGPGSVCTTRKKAGVGYPQLSAVLECADASHGLNGHVMSDGGCTNP 228
Query: 341 GDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQ 400
GD+ KA GAD VM+G LLAG + G+ V +G+KYK + GM S AM K YQ
Sbjct: 229 GDVAKAFGGGADFVMIGGLLAGHDQCGGEVVEKDGKKYKLFYGMSSDTAMKK------YQ 282
Query: 401 GGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIIT 460
G + R EG +PYRG VS ++ L+GGL++ Y+GA +KEL ++ FV +T
Sbjct: 283 GSVAEYR--ASEGKTIYMPYRGDVSRTIHDLLGGLRSACTYIGATKLKELSKRATFVRVT 340
>gb|AAG23534.1|AF244585_1 (AF244585) IMP dehydrogenase [Carboxydothermus hydrogenoformans]
Length = 130
Score = 153 bits (383), Expect = 4e-36
Identities = 79/131 (60%), Positives = 94/131 (71%), Gaps = 4/131 (3%)
Query: 354 VMLGNLLAGTK-EAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPE 412
VMLG+L + APGK R YK YRGMGSLGAM +G +RY+Q +K VPE
Sbjct: 3 VMLGSLFGWNRGNAPGKLKSWQERCYKVYRGMGSLGAMKEGSKDRYFQEN---EQKLVPE 59
Query: 413 GVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDI 472
GVEG VP++G VSE ++QL+GGL+AGMGY G RNI ELK K +F+ IT AGLRESHPHD+
Sbjct: 60 GVEGRVPFKGPVSETIFQLIGGLRAGMGYCGVRNIYELKTKTKFIKITQAGLRESHPHDV 119
Query: 473 IITNEAPNYPL 483
IT EAPNY L
Sbjct: 120 TITKEAPNYSL 130
>gi|7706109 GMPR2 for guanosine monophosphate reductase isolog [Homo sapiens]
>gi|7384853|dbj|BAA93080.1| (AB032903) guanosine
monophosphate reductase isolog [Homo sapiens]
>gi|9956932|gb|AAG09132.1|AF135159_1 (AF135159) GMP
reductase [Homo sapiens]
Length = 348
Score = 150 bits (374), Expect = 4e-35
Identities = 85/220 (38%), Positives = 130/220 (58%), Gaps = 11/220 (5%)
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDLTF--ADAVKVGIGPGSI 300
I +D A+ ++ ++ +K++R++ I+ GN+ + V++L AD +KVGIGPGS+
Sbjct: 126 ICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSV 185
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR GVG PQ++A+ AD A ++I+DGG GD+ KA AGAD VMLG +L
Sbjct: 186 CTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGML 245
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AG E+ G+ + +G+KYK + GM S AM K Y GG + R EG VP+
Sbjct: 246 AGHSESGGELIERDGKKYKLFYGMSSEMAMKK------YAGGVAEYR--ASEGKTVEVPF 297
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIIT 460
+G V + ++GG+++ YVGA +KEL + F+ +T
Sbjct: 298 KGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVT 337
>gi|11434007 GMPR2 for guanosine monophosphate reductase isolog [Homo sapiens]
Length = 348
Score = 150 bits (374), Expect = 4e-35
Identities = 85/220 (38%), Positives = 130/220 (58%), Gaps = 11/220 (5%)
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDLTF--ADAVKVGIGPGSI 300
I +D A+ ++ ++ +K++R++ I+ GN+ + V++L AD +KVGIGPGS+
Sbjct: 126 ICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSV 185
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR GVG PQ++A+ AD A ++I+DGG GD+ KA AGAD VMLG +L
Sbjct: 186 CTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGML 245
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AG E+ G+ + +G+KYK + GM S AM K Y GG + R EG VP+
Sbjct: 246 AGHSESGGELIERDGKKYKLFYGMSSEMAMKK------YAGGVAEYR--ASEGKTVEVPF 297
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIIT 460
+G V + ++GG+++ YVGA +KEL + F+ +T
Sbjct: 298 KGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVT 337
>sp|O16294|GUAC_CAEEL PROBABLE GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE)
(GUANOSINE MONOPHOSPHATE REDUCTASE)
>gi|7427797|pir||T03917 GMP reductase (EC 1.6.6.8)
F32D1.5 - Caenorhabditis elegans
>gi|2291231|gb|AAB65350.1| (AF016427) Contains
similarity to Pfam domain: PF00478 (IMPDH), Score=435.3,
E-value=1.7e-127, N=1 [Caenorhabditis elegans]
Length = 358
Score = 148 bits (371), Expect = 1e-34
Identities = 86/242 (35%), Positives = 136/242 (55%), Gaps = 17/242 (7%)
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDLTF--ADAVKVGIGPGSI 300
I +D A+ ++ ++ ++ +R+ I+ GN+ + V++L AD VKVGIGPGS+
Sbjct: 127 ICLDVANGYSESFVEFIRRVREAYPKHTIMAGNVVTGEMVEELILSGADIVKVGIGPGSV 186
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR AGVG PQ++A+ AD A +V++DGG GD+ KA AGAD VM+G L
Sbjct: 187 CTTRKKAGVGYPQLSAVLECADAAHGLNGHVMSDGGCSNPGDVAKAFGAGADFVMIGGLF 246
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AG ++ G + NG+K+K + GM S AM K + G + R EG +PY
Sbjct: 247 AGHDQSGGDLIEHNGKKFKLFYGMSSDTAMKK------HHGSVAEYR--ASEGKTVTIPY 298
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN 480
RG V+ + ++GG+++ Y GA+++KEL ++ F+ +T +D+ + E P
Sbjct: 299 RGDVNGTVQDILGGIRSACTYTGAKHLKELAKRATFIRVT------QQTNDMYVPFEVPT 352
Query: 481 YP 482
P
Sbjct: 353 VP 354
>sp|P57300|GUAC_BUCAI GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE)
(GUANOSINE MONOPHOSPHATE REDUCTASE)
>gi|10038886|dbj|BAB12921.1| (AP001118) GMP reductase
[Buchnera sp. APS]
Length = 349
Score = 147 bits (367), Expect = 3e-34
Identities = 93/264 (35%), Positives = 142/264 (53%), Gaps = 17/264 (6%)
Query: 206 KKYKNAVRDENGELL----VAAAVSPFDIRRAIELDRAGADV--IVVDTAHAHNLKAIKA 259
+++KN V + E+L V+ S D + ++ +++ I +D A+ ++ +
Sbjct: 82 EEWKNFVCLSSKEILNHVIVSIGTSNIDFLKIKKIFLLSSELKYICIDVANGYSEHIVSF 141
Query: 260 MKEMRQKV-DADFIVGNIANPKAVDDLTF--ADAVKVGIGPGSICTTRIVAGVGVPQITA 316
+K +R D GN+ + V++L AD VKVGIGPGS+CTTR+ GVG PQ++A
Sbjct: 142 LKLVRDYFPDKIICAGNVVTGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSA 201
Query: 317 IAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGR 376
I AD A +I+DGG SGDI KA GAD VMLG +L+G KE G + +
Sbjct: 202 IIECADAAHGLNGQIISDGGCTVSGDIAKAFGGGADFVMLGGMLSGHKECSGDIIEEKSK 261
Query: 377 KYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLK 436
KY + GM S+ AM + Y+G R EG +P+RG V + ++GGL+
Sbjct: 262 KYMIFYGMSSVSAMQR------YEGKIAGYR--ASEGKTVKIPFRGGVDSTIRDILGGLR 313
Query: 437 AGMGYVGARNIKELKEKGEFVIIT 460
+ YVGA +KEL ++ F+ +T
Sbjct: 314 SSCTYVGAEKLKELTKRTTFIRVT 337
>gi|11321611 guanosine monophosphate reductase; guanine monophosphate reductase
[Homo sapiens] >gi|106101|pir||B32902 GMP reductase (EC
1.6.6.8) - human >gi|182867|gb|AAA52498.1| (M24470)
glucose-6-phosphate dehydrogenase [Homo sapiens]
Length = 345
Score = 145 bits (362), Expect = 1e-33
Identities = 84/220 (38%), Positives = 124/220 (56%), Gaps = 11/220 (5%)
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDLTF--ADAVKVGIGPGSI 300
I +D A+ ++ ++ +K +R K I+ GN+ + V++L AD +KVG+GPGS+
Sbjct: 126 ICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSV 185
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR GVG PQ++A+ AD A ++I+DGG GD+ KA GAD VMLG +
Sbjct: 186 CTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGTGADFVMLGGMF 245
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
+G E G+ + NGRK K + GM S AM K + GG + R EG VPY
Sbjct: 246 SGHTECAGEVIERNGRKLKLFYGMSSDTAMNK------HAGGVAEYR--ASEGKTVEVPY 297
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIIT 460
+G V + ++GGL++ YVGA +KEL + F+ +T
Sbjct: 298 KGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVT 337
>sp|P36959|GUAC_HUMAN GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE)
(GUANOSINE MONOPHOSPHATE REDUCTASE)
Length = 345
Score = 145 bits (362), Expect = 1e-33
Identities = 85/220 (38%), Positives = 124/220 (55%), Gaps = 11/220 (5%)
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDLTF--ADAVKVGIGPGSI 300
I +D A+ ++ ++ +K +R K I+ GN+ + V++L AD +KVG+GPGS+
Sbjct: 126 ICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSV 185
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR GVG PQ++A+ AD A ++I+DGG GD+ KA AGAD VMLG +
Sbjct: 186 CTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMF 245
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
+G E G+ NGRK K + GM S AM K + GG + R EG VPY
Sbjct: 246 SGHTECAGEVFERNGRKLKLFYGMSSDTAMNK------HAGGVAEYR--ASEGKTVEVPY 297
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIIT 460
+G V + ++GGL++ YVGA +KEL + F+ +T
Sbjct: 298 KGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVT 337
>pir||F82490 GMP reductase VCA0197 [imported] - Vibrio cholerae (group O1 strain
N16961) >gi|9657589|gb|AAF96110.1| (AE004359) GMP
reductase [Vibrio cholerae]
Length = 347
Score = 145 bits (361), Expect = 1e-33
Identities = 87/254 (34%), Positives = 140/254 (54%), Gaps = 13/254 (5%)
Query: 209 KNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVV--DTAHAHNLKAIKAMKEMRQK 266
K+A + ++V+ S D ++ ++ ++I + D A+ ++ ++ ++ +R
Sbjct: 89 KSADKATLNNVMVSTGTSEADFQKTKDVMALSDELIFICIDIANGYSEHLVEYVQRVRAA 148
Query: 267 V-DADFIVGNIANPKAVDDLTFA--DAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADR 323
D GN+ V++L A D VKVGIGPGS+CTTR+ GVG PQ++AI AD
Sbjct: 149 FPDKVISAGNVVTGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADA 208
Query: 324 AQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRG 383
A G +I DGG GD+ KA GAD VMLG +LAG +EA G+ ++ +G + ++ G
Sbjct: 209 AHGLGGRIIGDGGCTCPGDVAKAFGGGADFVMLGGMLAGHEEAGGELIVKDGETFMKFYG 268
Query: 384 MGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVG 443
M S AM K + GG R EG ++PYRG+V + ++GG+++ YVG
Sbjct: 269 MSSKSAMDK------HSGGVAGYR--AAEGKTVLLPYRGSVHGTIQDILGGVRSTCTYVG 320
Query: 444 ARNIKELKEKGEFV 457
A ++EL ++ F+
Sbjct: 321 AAELRELTKRTTFI 334
>gb|AAF64252.1|AF153721_1 (AF153721) GMP-reductase GMR-1 [Onchocerca volvulus]
Length = 364
Score = 144 bits (360), Expect = 2e-33
Identities = 84/220 (38%), Positives = 127/220 (57%), Gaps = 11/220 (5%)
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVDADFI-VGNIANPKAVDDLTF--ADAVKVGIGPGSI 300
I +D A+ ++ + ++ +R++ I GN+ + ++L AD VKVGIG GS+
Sbjct: 129 ICLDVANGYSEVFVDFIRRVREEFPRHTIFAGNVVTGEMTEELILSGADVVKVGIGSGSV 188
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR AGVG PQ++A+ AD + +V++DGG GD+ KA+ AGAD VM+G L
Sbjct: 189 CTTRKKAGVGYPQLSAVLECADASHGLNGHVMSDGGCTNPGDVAKALGAGADFVMIGGLF 248
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
AG + G V +G+KYK + GM S AM K ++G + R EG VPY
Sbjct: 249 AGHDQCGGDTVEKDGQKYKLFYGMSSDTAMEK------HEGSVAEYR--ASEGKTITVPY 300
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIIT 460
RG +S+ + L+GGL++ Y GA+ +KEL ++ FV +T
Sbjct: 301 RGDISKTVQDLLGGLRSACTYTGAKKLKELSKRATFVRVT 340
>sp|Q9Z244|GUAC_RAT GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE)
(GUANOSINE MONOPHOSPHATE REDUCTASE)
>gi|3907579|gb|AAC78657.1| (AF090867) guanosine
monophosphate reductase [Rattus norvegicus]
Length = 345
Score = 143 bits (358), Expect = 3e-33
Identities = 83/220 (37%), Positives = 124/220 (55%), Gaps = 11/220 (5%)
Query: 244 IVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDLTF--ADAVKVGIGPGSI 300
I +D A+ ++ ++ +K +R K I+ GN+ + V++L AD +KVG+GPGS+
Sbjct: 126 ICLDVANGYSEHFVEFVKLVRSKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSV 185
Query: 301 CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL 360
CTTR GVG PQ++A+ AD A ++I+DG GD+ KA AGAD VMLG +
Sbjct: 186 CTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGSCTCPGDVAKAFGAGADFVMLGGMF 245
Query: 361 AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY 420
+G E G+ + NG+K K + GM S AM K + GG + R EG VPY
Sbjct: 246 SGHTECAGEVIERNGQKLKLFYGMSSDTAMKK------HAGGVAEYR--ASEGKTVEVPY 297
Query: 421 RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIIT 460
+G V + ++GGL++ YVGA +KEL + F+ +T
Sbjct: 298 KGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVT 337
>pir||H64732 GMP reductase (EC 1.6.6.8) - Escherichia coli
>gi|1786293|gb|AAC73215.1| (AE000119) GMP reductase
[Escherichia coli K12]
Length = 347
Score = 140 bits (349), Expect = 4e-32
Identities = 87/254 (34%), Positives = 137/254 (53%), Gaps = 15/254 (5%)
Query: 210 NAVRDENGELLVAAAVSPFDIRRA---IELDRAGADVIVVDTAHAHNLKAIKAMKEMRQK 266
N+ D ++V+ S D + ++L+ A + + +D A+ ++ ++ + + R+
Sbjct: 90 NSSADVLKHVMVSTGTSDADFEKTKQILDLNPA-LNFVCIDVANGYSEHFVQFVAKAREA 148
Query: 267 VDADFI-VGNIANPKAVDDLTF--ADAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADR 323
I GN+ + ++L AD VKVGIGPGS+CTTR+ GVG PQ++A+ AD
Sbjct: 149 WPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADA 208
Query: 324 AQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRG 383
A G +++DGG GD+ KA GAD VMLG +LAG +E+ G+ V NG K+ + G
Sbjct: 209 AHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYG 268
Query: 384 MGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVG 443
M S AM + + GG + R EG +P RG V ++GGL++ YVG
Sbjct: 269 MSSESAMKR------HVGGVAEYR--AAEGKTVKLPLRGPVENTARDILGGLRSACTYVG 320
Query: 444 ARNIKELKEKGEFV 457
A +KEL ++ F+
Sbjct: 321 ASRLKELTKRTTFI 334
>emb|CAA15623.1| (AL009031) GMP reductase (Guanosine 5'-monophosphate
oxidoreductase, EC 1.6.6.8) [Homo sapiens]
Length = 190
Score = 139 bits (348), Expect = 5e-32
Identities = 78/189 (41%), Positives = 108/189 (56%), Gaps = 10/189 (5%)
Query: 274 GNIANPKAVDDLTF--ADAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADRAQEYGLYV 331
GN+ + V++L AD +KVG+GPGS+CTTR GVG PQ++A+ AD A ++
Sbjct: 2 GNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHI 61
Query: 332 IADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMM 391
I+DGG GD+ KA AGAD VMLG + +G E G+ NGRK K + GM S AM
Sbjct: 62 ISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMN 121
Query: 392 KGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELK 451
K + GG + R EG VPY+G V + ++GGL++ YVGA +KEL
Sbjct: 122 K------HAGGVAEYR--ASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELS 173
Query: 452 EKGEFVIIT 460
+ F+ +T
Sbjct: 174 RRATFIRVT 182
>sp|P15344|GUAC_ECOLI GMP REDUCTASE (GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE)
>gi|78478|pir||S01671 GMP reductase (EC 1.6.6.8) -
Escherichia coli >gi|42616|emb|CAA30751.1| (X07917) GMP
reductase (AA 1-346) [Escherichia coli]
>gi|473772|dbj|BAA05561.1| (D26562) 'GMP reductase'
[Escherichia coli]
Length = 346
Score = 134 bits (334), Expect = 2e-30
Identities = 87/254 (34%), Positives = 137/254 (53%), Gaps = 16/254 (6%)
Query: 210 NAVRDENGELLVAAAVSPFDIRRA---IELDRAGADVIVVDTAHAHNLKAIKAMKEMRQK 266
N+ D ++V+ S D + ++L+ A + + +D A+ ++ ++ + + R+
Sbjct: 90 NSSADVLKHVMVSTGTSDADFEKTKQILDLNPA-LNFVCIDVANGYSEHFVQFVAKAREA 148
Query: 267 VDADFI-VGNIANPKAVDDLTF--ADAVKVGIGPGSICTTRIVAGVGVPQITAIAMVADR 323
I GN+ + ++L AD VKVGIGPGS+CTTR+ GVG PQ++A+ AD
Sbjct: 149 WPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADA 208
Query: 324 AQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRG 383
A G +++DGG GD+ KA A AD VMLG +LAG +E+ G+ V NG K+ + G
Sbjct: 209 AHGLGGMIVSDGGCTTPGDVAKAFAR-ADFVMLGGMLAGHEESGGRIVEENGEKFMLFYG 267
Query: 384 MGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVG 443
M S AM + + GG + R EG +P RG V ++GGL++ YVG
Sbjct: 268 MSSESAMKR------HVGGVAEYR--AAEGKTVKLPLRGPVENTARDILGGLRSACTYVG 319
Query: 444 ARNIKELKEKGEFV 457
A +KEL ++ F+
Sbjct: 320 ASRLKELTKRTTFI 333
>pir||T42083 IMP dehydrogenase (EC 1.1.1.205) - fission yeast
(Schizosaccharomyces pombe) (fragment)
>gi|1749420|dbj|BAA13769.1| (D89106) similar to Human
inosin-5'-monophosphate dehydrogenase 1, SWISS-PROT
Accession Number P20839 [Schizosaccharomyces pombe]
Length = 232
Score = 132 bits (328), Expect = 1e-29
Identities = 79/225 (35%), Positives = 132/225 (58%), Gaps = 11/225 (4%)
Query: 40 ITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKKAERFI 99
I+ N+ L P +S+ MDTVTE +MA+ MA GG+GVIH N + EEQ V++VKK E
Sbjct: 1 ISRNIVLKTPFMSSPMDTVTEDQMAIYMALLGGIGVIHHNCTPEEQAAMVRKVKKYENGF 60
Query: 100 VEDVITISPEETVDFALFLMEKHDIDGLPVVEN----EKVVGIISKKDIAARE--GKLVK 153
+ D + SP+ TV L + E G+P+ EN K+VGI++ +D+ + V
Sbjct: 61 ILDPVVFSPQHTVGDVLKIKETKGFSGIPITENGKLRGKLVGIVTSRDVQFHKDTNTPVT 120
Query: 154 ELMT--KDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNA 211
E+MT +++IT E I +E A +++ +++ +LPVVDK+ L+ L++++DL+ + A
Sbjct: 121 EVMTPREELITTAEGISLERANEMLRKSKKGKLPVVDKDDNLVALLSLTDLMKNLHFPLA 180
Query: 212 VR-DENGELLVAAAVS--PFDIRRAIELDRAGADVIVVDTAHAHN 253
+ + +L+V AA+ D R L AG D +V+D++ ++
Sbjct: 181 SKTSDTKQLMVGAAIGTRDDDPTRLALLAEAGLDAVVIDSSQGNS 225
>gb|AAC21895.1| (U32708) H. influenzae predicted coding region HI0221.1
[Haemophilus influenzae Rd]
Length = 163
Score = 126 bits (313), Expect = 6e-28
Identities = 58/110 (52%), Positives = 78/110 (70%), Gaps = 1/110 (0%)
Query: 372 IINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVLYQL 431
+ GR +K YRGMGSLGAM KG ++RY+Q K VPEG+EG +PY+G + E+++Q
Sbjct: 52 LYQGRAFKSYRGMGSLGAMAKGSSDRYFQSDNAAD-KLVPEGIEGRIPYKGYLKEIIHQQ 110
Query: 432 VGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY 481
+GGL++ MG G I EL+ K EFV I+ AG++ESH HD+ IT EAPNY
Sbjct: 111 MGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITKEAPNY 160
>pir||F64626 probable GMP reductase (EC 1.6.6.8) - Helicobacter pylori (strain
26695) >gi|2313987|gb|AAD07901.1| (AE000596) GMP
reductase (guaC) [Helicobacter pylori 26695]
Length = 327
Score = 122 bits (304), Expect = 7e-27
Identities = 76/226 (33%), Positives = 127/226 (55%), Gaps = 24/226 (10%)
Query: 242 DVIVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDL--TFADAVKVGIGPG 298
D I +D AH H+ I+ ++ ++ + F++ GN+ P+AV +L ADA KVGIGPG
Sbjct: 114 DYITIDIAHGHSNSVIEMIQRIKTHLPETFVIAGNVGTPEAVRELENAGADATKVGIGPG 173
Query: 299 SICTTRIVAGVGVP--QITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVML 356
+C T+I G G Q+ A+ A A++ +IADGGI+ GDIVK+I GA VM+
Sbjct: 174 KVCITKIKTGFGTGGWQLAALRWCAKAARKP---IIADGGIRTHGDIVKSIRFGATMVMI 230
Query: 357 GNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEG 416
G+L AG +E+ G+ I NG YK+Y G S + K K EG +
Sbjct: 231 GSLFAGHEESSGETKIENGIAYKEYFGSAS---------------EFQKGEKKNIEGKKI 275
Query: 417 VVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSA 462
+ ++G++ + L ++ L++ + Y G R+++ ++ K ++VI+ ++
Sbjct: 276 WIQHKGSLKDTLVEMHQDLQSSISYAGGRDLEAIR-KVDYVIVKNS 320
>pir||A71887 probable GMP reductase (EC 1.6.6.8) - Helicobacter pylori (strain
J99) >gi|4155370|gb|AAD06382.1| (AE001509) GMP REDUCTASE
[Helicobacter pylori J99]
Length = 325
Score = 121 bits (301), Expect = 2e-26
Identities = 75/226 (33%), Positives = 126/226 (55%), Gaps = 24/226 (10%)
Query: 242 DVIVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDL--TFADAVKVGIGPG 298
D I +D AH H+ I+ ++ ++ ++ F++ GN+ P+AV +L ADA KVGIGPG
Sbjct: 112 DYITIDIAHGHSNSVIEMIQRIKTRLPETFVIAGNVGTPEAVRELENAGADATKVGIGPG 171
Query: 299 SICTTRIVAGVGVP--QITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVML 356
+C T+I G G Q+ A+ A A++ +IADGGI+ GDI K+I GA VM+
Sbjct: 172 KVCITKIKTGFGTGGWQLAALRWCAKAARKP---IIADGGIRTHGDIAKSIRFGATMVMI 228
Query: 357 GNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEG 416
G+L AG +E+ G+ I NG YK+Y G S + K K EG +
Sbjct: 229 GSLFAGHEESSGETKIENGIAYKEYFGSAS---------------EFQKGEKKNIEGKKI 273
Query: 417 VVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSA 462
+ ++G++ L ++ L++ + Y G R+++ ++ K ++VI+ ++
Sbjct: 274 WIQHKGSLKNTLIEMHQDLQSSISYAGGRDLEAIR-KVDYVIVKNS 318
>pir||C70015 probable GMP reductase (EC 1.6.6.8) yumD - Bacillus subtilis
>gi|1934831|emb|CAB07955.1| (Z93939) unknown [Bacillus
subtilis] >gi|2635710|emb|CAB15203.1| (Z99120) similar
to GMP reductase [Bacillus subtilis]
Length = 326
Score = 119 bits (295), Expect = 8e-26
Identities = 72/240 (30%), Positives = 129/240 (53%), Gaps = 24/240 (10%)
Query: 228 FDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQKVDADFIV-GNIANPKAVDDL- 285
++ R + + + + +D AH H+ I+ ++ +++ + F++ GN+ P+AV +L
Sbjct: 99 YEFVRQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELE 158
Query: 286 -TFADAVKVGIGPGSICTTRIVAGVGVP--QITAIAMVADRAQEYGLYVIADGGIKYSGD 342
ADA KVGIGPG +C T+I G G Q+ A+ A A + +IADGGI+ GD
Sbjct: 159 NAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKP---IIADGGIRTHGD 215
Query: 343 IVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGG 402
I K+I GA VM+G+L AG +E+PG+ + +G+ YK+Y G S
Sbjct: 216 IAKSIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSAS---------------E 260
Query: 403 YMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSA 462
+ K K EG + V ++G++ + L ++ L++ + Y G + ++ ++VI+ ++
Sbjct: 261 FPKGEKKNVEGKKMHVAHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNV-DYVIVKNS 319
>prf||1110192A gene gua [Escherichia coli]
Length = 96
Score = 112 bits (277), Expect = 1e-23
Identities = 55/95 (57%), Positives = 71/95 (73%)
Query: 8 LERAIRGYTFDDVLLIPQATEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAM 67
L A TFDDVLL+P + V P D+STQ+T ++LNIP+LSAAMDTVTE +A+A+
Sbjct: 2 LRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIAL 61
Query: 68 AREGGLGVIHRNMSIEEQVEQVKRVKKAERFIVED 102
A+EGG+G IH+NMSIE Q E+V+RVKK E +V D
Sbjct: 62 AQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTD 96
>pir||S75050 IMP dehydrogenase homolog (EC 1.-.-.-) guaB - Synechocystis sp.
(strain PCC 6803) >gi|1652995|dbj|BAA17912.1| (D90910)
IMP dehydrogenase subunit [Synechocystis sp.]
Length = 387
Score = 110 bits (273), Expect = 3e-23
Identities = 101/306 (33%), Positives = 140/306 (45%), Gaps = 69/306 (22%)
Query: 181 IDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDI------RRAI 234
+DR+ V K +GL M +L A + E+ A ++ + + A
Sbjct: 91 LDRIASVGKT-EFVGL--MQELYAEPIKPELITKRIQEIQAAGGIAAVSLTPVGASKYAS 147
Query: 235 ELDRAGADVI-----VVDTAH-----AHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDD 284
+ AGAD++ VV TAH +L +K +EM V ++GN + +
Sbjct: 148 TVAEAGADLLFIQATVVSTAHLSPESVESLDLVKLCQEMPMPV----VLGNCVTYEVSLE 203
Query: 285 LTFADA--VKVGIGPGSICTTRIVAGVGVPQITAIAMVA----DRAQEYGLYV--IADGG 336
L A A V VGIGPG+ CT+R V GVGVPQ TAIA A D QE G YV IADGG
Sbjct: 204 LMRAGAAAVLVGIGPGAACTSRGVLGVGVPQPTAIADCAAARDDYLQETGRYVPVIADGG 263
Query: 337 IKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAE 396
I GDI K IA GADAVM+G+ +A EAPG
Sbjct: 264 IITGGDICKCIACGADAVMIGSPIARAAEAPG---------------------------- 295
Query: 397 RYYQGGYMKTRKFVPEGVEGVVPYRGTVSEVL----------YQLVGGLKAGMGYVGARN 446
R + G +P G V GT+ E+L + L+G +K MG +GA++
Sbjct: 296 RGFHWGMATPSPVLPRGTRINVGTTGTIREILVGPAKLDDGTHNLLGAIKTSMGTLGAKD 355
Query: 447 IKELKE 452
+KE+++
Sbjct: 356 MKEMQQ 361
>pir||H72290 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
>gi|4981687|gb|AAD36216.1|AE001771_9 (AE001771)
conserved hypothetical protein [Thermotoga maritima]
Length = 215
Score = 89.7 bits (219), Expect = 6e-17
Identities = 58/155 (37%), Positives = 86/155 (55%), Gaps = 29/155 (18%)
Query: 98 FIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIAARE--------- 148
F+ + ITI+PE + AL LM+++ I L V++NEK+VGI+++KD+
Sbjct: 6 FMTRNPITIAPETSFSEALKLMKQNKIKRLIVMKNEKIVGIVTEKDLLYASPSKATTLNI 65
Query: 149 -------GKL-VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMS 200
KL ++E+MTKDV+TV EN +E+A +IM E I LPVVD GRL+G+IT +
Sbjct: 66 WELHYLLSKLKIEEIMTKDVVTVNENTPIEDAARIMEEKDISGLPVVDDAGRLVGIITQT 125
Query: 201 DLV------------ARKKYKNAVRDENGELLVAA 223
D+ +Y + D+ GELL A
Sbjct: 126 DIFKVFVEIFGTKREGTIRYTMEMPDKPGELLEVA 160
>emb|CAB82010.1| (AL161755) putative inosine-5'-monophosphate dehydrogenase
[Streptomyces coelicolor A3(2)]
Length = 374
Score = 88.5 bits (216), Expect = 1e-16
Identities = 67/176 (38%), Positives = 93/176 (52%), Gaps = 23/176 (13%)
Query: 212 VRDENGELLVAAAVSPFDIRRAIELDRA----GADVIV-----VDTAHAHNLKAIKAMKE 262
VRD ++ AAA+SP +R + +A G D+ V V H +K+
Sbjct: 127 VRDSG--VVTAAALSP---QRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGSHEPLNLKQ 181
Query: 263 MRQKVDADFIVGNIANPKAVDDL--TFADAVKVGIGPGSICTTRIVAGVGVPQITAIAMV 320
++D IVG A A L T A V VG G G+ TTR V G+ VP TA+A V
Sbjct: 182 FIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADV 241
Query: 321 ADRAQEYG-------LYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGK 369
A ++Y ++VIADGG+ +SGD+ KAIA GAD+VM+G+ LA +APG+
Sbjct: 242 AAARRDYMDESGGRYVHVIADGGVGWSGDLPKAIACGADSVMMGSPLARATDAPGR 297
>sp|P50100|IMDH_METKA PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE)
(IMPDH) (IMPD) (ORFX) >gi|1002715|gb|AAA92086.1|
(U31567) similar to the inosine monophosphate
dehydrogenase from Pyrococcus furiosus (SwissProt
Accession Number P42851); orfX protein; Method:
conceptual translation supplied by author [Methanopyrus
kandleri]
Length = 172
Score = 86.2 bits (210), Expect = 7e-16
Identities = 47/123 (38%), Positives = 80/123 (64%), Gaps = 9/123 (7%)
Query: 102 DVITISPEETVDFALFLMEKHDIDGLPVV-ENEKVVGIISKKDIAAR---EGK-----LV 152
DVIT SP ET + M +H I + +V E ++ +GII+++D+ + +GK +
Sbjct: 13 DVITGSPTETAVEIAYKMREHGIGSVVIVNEKDEPIGIITERDLVIKVVSQGKNPDEVIA 72
Query: 153 KELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAV 212
+++M++ VITV E++EV EA+K+M++ I RLP+VD G+LIG++TM D++ + Y A
Sbjct: 73 RDIMSQPVITVEEDMEVNEAVKLMVDKGIRRLPIVDDNGKLIGIVTMQDILQVEPYLVAT 132
Query: 213 RDE 215
+E
Sbjct: 133 IEE 135
>gb|AAK42850.1| Conserved hypothetical protein [Sulfolobus solfataricus]
Length = 250
Score = 83.5 bits (203), Expect = 5e-15
Identities = 45/145 (31%), Positives = 88/145 (60%), Gaps = 11/145 (7%)
Query: 94 KAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDI-----AARE 148
K + + +D++ +SP + V+ + +M ++I G+PVV+N +VGI ++++I ++
Sbjct: 67 KVKDIMSKDLVIVSPNDDVNHVVRIMLMNNIGGIPVVDNNVIVGIFTEREILKLIASSMF 126
Query: 149 GKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKY 208
LV +M+ ++I++ E + +A K+M+ N + RLPV K+ RL+G+IT +D+V
Sbjct: 127 SGLVDSVMSSNIISIGEENTIMDAAKLMVMNNVRRLPVFSKDNRLVGIITAADIV----- 181
Query: 209 KNAVRDEN-GELLVAAAVSPFDIRR 232
K +++N G++L A +P I R
Sbjct: 182 KYLAKNKNIGKVLDAGTKNPITINR 206
>sp|Q58629|YC32_METJA HYPOTHETICAL PROTEIN MJ1232 >gi|2128738|pir||G64453 conserved
hypothetical protein MJ1232 - Methanococcus jannaschii
>gi|1591864|gb|AAB99237.1| (U67564) conserved
hypothetical protein [Methanococcus jannaschii]
Length = 296
Score = 81.5 bits (198), Expect = 2e-14
Identities = 51/132 (38%), Positives = 81/132 (60%), Gaps = 5/132 (3%)
Query: 76 IHRNMSIEEQ-VEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEK 134
IHR + I+ V + +K + I E V TI+P T+ L + I G PVV+N+K
Sbjct: 153 IHRILLIDVLGVSSIPNIKVGDVGIKE-VWTINPNCTLRETAKLFAEKYISGAPVVDNDK 211
Query: 135 VVGIISKKDIAAREG---KLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEG 191
+VG+IS DIA K VKE+M +DVIT+ ++ ++ +ALKIM +N + RL +VD
Sbjct: 212 LVGVISLHDIAENIDNIDKKVKEVMRRDVITIHKDEKIYDALKIMNKNNVGRLVIVDDNN 271
Query: 192 RLIGLITMSDLV 203
+++G+IT +D++
Sbjct: 272 KIVGIITRTDIL 283
>pir||F72780 hypothetical protein APE0231 - Aeropyrum pernix (strain K1)
>gi|5103623|dbj|BAA79144.1| (AP000058) 287aa long
hypothetical protein [Aeropyrum pernix]
Length = 287
Score = 80.8 bits (196), Expect = 3e-14
Identities = 56/166 (33%), Positives = 89/166 (52%), Gaps = 17/166 (10%)
Query: 98 FIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIA----------AR 147
++ DV T+SP++T+ A LM HDI LPVVE K+ GII+ DIA
Sbjct: 8 YMTRDVYTVSPDDTLAHARKLMLTHDISRLPVVEGSKLRGIITITDIADALVRKYPSRPA 67
Query: 148 EGKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLV---- 203
V+E+M +DV+T+ V+ A +M+++ I +PVV +G L G+IT +DL
Sbjct: 68 NSIYVREVMARDVVTIEGTKSVKTAASLMLKHNIGGVPVVAPDGTLEGIITRTDLTRYYS 127
Query: 204 ARKKYKNAVRDENGELLVAA--AVSPFDIRRAIELDRAGADVIVVD 247
+ K N V++ E+ A S F + + +E+D G V+++D
Sbjct: 128 EKMKGVNLVKEFMREIYAKARREHSIFYVLKLMEIDATG-KVLILD 172
>pir||F69037 MJ0188 homolog - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2622389|gb|AAB85764.1| (AE000893)
inosine-5'-monophosphate dehydrogenase related protein
VI [Methanobacterium thermoautotrophicum]
Length = 269
Score = 80.4 bits (195), Expect = 4e-14
Identities = 37/107 (34%), Positives = 70/107 (64%), Gaps = 1/107 (0%)
Query: 98 FIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIAAREG-KLVKELM 156
++ DVIT+S + + + LM++ DG PV +N V+G+++ D+ + K V E+M
Sbjct: 10 YMTRDVITVSSDTSTAEIIKLMKETGHDGFPVKDNGSVIGMVTAFDLLIKPWVKTVSEIM 69
Query: 157 TKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203
++DV+ +++ + +A ++M I RLPV++KEG+L+G+IT +D+V
Sbjct: 70 SRDVVVADQDMSLNDAARVMFRMGISRLPVINKEGKLVGIITNTDIV 116
>pir||G75056 dehydrogenase PAB0961 - Pyrococcus abyssi (strain Orsay)
>gi|5458861|emb|CAB50348.1| (AJ248287) dehydrogenase
[Pyrococcus abyssi]
Length = 392
Score = 80.4 bits (195), Expect = 4e-14
Identities = 51/152 (33%), Positives = 82/152 (53%), Gaps = 21/152 (13%)
Query: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN 132
LGVI +E V + +K E F+ +DVIT+ P++TV AL M H I +PVV+
Sbjct: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169
Query: 133 E-KVVGIISKKDIA---------AREGKL-----------VKELMTKDVITVPENIEVEE 171
E K+ G+++ D+ A+ G+L ++E M K VIT+ + E
Sbjct: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203
A+ M +N ID L VVD+ +++G++T+ DL+
Sbjct: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
Score = 78.0 bits (189), Expect = 2e-13
Identities = 75/264 (28%), Positives = 133/264 (49%), Gaps = 21/264 (7%)
Query: 35 DVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL--GVIHRNMSIEEQVEQVKRV 92
+V T + +N P LS A+ + + + + + + + GV+ +++ I ++
Sbjct: 8 EVMTDRYAKIDINAP-LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKW-DPT 65
Query: 93 KKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE-KVVGIIS-----KKDIAA 146
K R + + + P + + A L+ + D+ LPV EN+ +++G+IS ++ +A
Sbjct: 66 KAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAE 125
Query: 147 REGKL-VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVAR 205
GK V+E MTKDVIT+ + V +AL M ++ I R+PVVD+EG+L GL+T+ DL+ R
Sbjct: 126 EFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIR 185
Query: 206 KKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQ 265
K + + GE L + PF +++L A ++ A +A+ MK+
Sbjct: 186 -FIKPRFKAQYGE-LAGEKIPPF----SMKLREAMIKGVITIMPEATIREAVSTMKD--N 237
Query: 266 KVDADFIVGNIANPKAVDDLTFAD 289
+D +V N K V LT D
Sbjct: 238 NIDGLVVVDE--NNKVVGILTVKD 259
>pir||D71175 hypothetical protein PH0600 - Pyrococcus horikoshii
>gi|3257006|dbj|BAA29689.1| (AP000002) 392aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 392
Score = 79.2 bits (192), Expect = 9e-14
Identities = 69/225 (30%), Positives = 114/225 (50%), Gaps = 22/225 (9%)
Query: 74 GVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE 133
GV+ +++ I ++ K R I + + P + + A L+ + D+ LPV EN+
Sbjct: 48 GVLTQDLIIRSHLKW-DPTKAKVRDIYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENK 106
Query: 134 -KVVGIISKKDIAAREG--------KLVKELMTKDVITVPENIEVEEALKIMIENRIDRL 184
+++G+IS DIA E K V+E MTKDVIT+ + V +AL +M ++ I R+
Sbjct: 107 AEIIGVIS--DIALLERVVAEEFGKKKVEEFMTKDVITLTPDDTVAKALAVMRDHGISRI 164
Query: 185 PVVDKEGRLIGLITMSDLVARKKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVI 244
P+V++EG+L GL+T+ DL+ R K + + GE LV + PF ++ + R ++
Sbjct: 165 PIVNEEGKLEGLVTLHDLILR-FIKPRFKAQTGE-LVGEKIPPFSMKLREAMIRGVITIL 222
Query: 245 VVDTAHAHNLKAIKAMKEMRQKVDADFIVGNIANPKAVDDLTFAD 289
T +A+ MK+ D D +V K V LT D
Sbjct: 223 PTATVR----EAVATMKDN----DIDGLVVVDEGNKVVGILTVKD 259
Score = 78.8 bits (191), Expect = 1e-13
Identities = 51/152 (33%), Positives = 83/152 (54%), Gaps = 21/152 (13%)
Query: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN 132
+GVI +E V + KK E F+ +DVIT++P++TV AL +M H I +P+V
Sbjct: 110 IGVISDIALLERVVAEEFGKKKVEEFMTKDVITLTPDDTVAKALAVMRDHGISRIPIVNE 169
Query: 133 E-KVVGIISKKDI---------AAREGKLV-----------KELMTKDVITVPENIEVEE 171
E K+ G+++ D+ A+ G+LV +E M + VIT+ V E
Sbjct: 170 EGKLEGLVTLHDLILRFIKPRFKAQTGELVGEKIPPFSMKLREAMIRGVITILPTATVRE 229
Query: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203
A+ M +N ID L VVD+ +++G++T+ DL+
Sbjct: 230 AVATMKDNDIDGLVVVDEGNKVVGILTVKDLL 261
>emb|CAB97003.1| (AJ293460) IMP dehydrogenase [Schizosaccharomyces pombe]
Length = 148
Score = 77.6 bits (188), Expect = 3e-13
Identities = 43/113 (38%), Positives = 67/113 (59%), Gaps = 3/113 (2%)
Query: 343 IVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGG 402
+VK+++ GA AVM+G LLAGT E+PG+ + G++YK YRGMGS+ AM G + G
Sbjct: 2 MVKSLSLGATAVMMGGLLAGTTESPGEYYVREGQRYKSYRGMGSIAAMEGTGVNKNASTG 61
Query: 403 YMKTRK---FVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
+ V +GV G+V +G++ L L GL+ + +G +++ EL E
Sbjct: 62 RYFSENDAVRVAQGVSGLVVDKGSLLRFLPYLYTGLQHALQDIGTKSLDELHE 114
>pir||S70312 hypothetical protein YAR075w - yeast (Saccharomyces cerevisiae)
(fragment)
Length = 134
Score = 76.9 bits (186), Expect = 5e-13
Identities = 44/117 (37%), Positives = 67/117 (56%), Gaps = 11/117 (9%)
Query: 343 IVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGG 402
I KA+A G+ VM+G +LAGT E+PG+ + +G++ K YRGMGS+ AM K G +G
Sbjct: 11 ITKALALGSSTVMMGGMLAGTTESPGEYLYQDGKRLKAYRGMGSIDAMQKTGT----KGN 66
Query: 403 YMKTRKF-------VPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
+R F V +GV G V +G++ + + L GL+ +G R++ LKE
Sbjct: 67 ASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCRSLTLLKE 123
>gi|6319353 Yar075wp [Saccharomyces cerevisiae] >gi|7429666|pir||S78078 IMP
dehydrogenase-related protein YAR075w - yeast
(Saccharomyces cerevisiae) >gi|2911246|gb|AAC09511.1|
(L28920) Yar075wp [Saccharomyces cerevisiae]
Length = 157
Score = 76.9 bits (186), Expect = 5e-13
Identities = 44/117 (37%), Positives = 67/117 (56%), Gaps = 11/117 (9%)
Query: 343 IVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGG 402
I KA+A G+ VM+G +LAGT E+PG+ + +G++ K YRGMGS+ AM K G +G
Sbjct: 11 ITKALALGSSTVMMGGMLAGTTESPGEYLYQDGKRLKAYRGMGSIDAMQKTGT----KGN 66
Query: 403 YMKTRKF-------VPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKE 452
+R F V +GV G V +G++ + + L GL+ +G R++ LKE
Sbjct: 67 ASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCRSLTLLKE 123
>gi|11497944 conserved hypothetical protein [Archaeoglobus fulgidus]
>gi|7450177|pir||D69291 conserved hypothetical protein
AF0332 - Archaeoglobus fulgidus
>gi|2650306|gb|AAB90905.1| (AE001082) conserved
hypothetical protein [Archaeoglobus fulgidus]
Length = 362
Score = 76.5 bits (185), Expect = 6e-13
Identities = 61/185 (32%), Positives = 97/185 (51%), Gaps = 7/185 (3%)
Query: 30 EPKDVDVSTQITPNVKLNIPILSAAMDTVTE-WEMAVAMAREGGLGVIHRNMSIEEQVEQ 88
E + +T+I + + I A T W + +A+ G R + +E +
Sbjct: 172 EKRSYAEATKIAAEIGRALAIFMAIFGIFTNPWLILIALFVYIGANEEERLVLLENVLG- 230
Query: 89 VKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIAARE 148
RV+ A+ E V+T++PE TV + L+ K G PVVE E++VGII+ DI E
Sbjct: 231 --RVRVADVMNTE-VVTVTPEMTVSEVIDLILKTKHLGFPVVEGERLVGIITLHDIIGVE 287
Query: 149 -GKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKK 207
+ V +M+++V+ V N EA KIM E I RLPVV+ GR++G+++ SDL+ K+
Sbjct: 288 PEERVGNIMSREVVAVSPNQSAFEAFKIMSEMGIGRLPVVE-HGRVVGIVSRSDLMRIKE 346
Query: 208 YKNAV 212
A+
Sbjct: 347 ILEAL 351
>pir||B72265 hypothetical protein TM1354 - Thermotoga maritima (strain MSB8)
>gi|4981914|gb|AAD36425.1|AE001789_10 (AE001789)
inosine-5-monophosphate dehydrogenase-related protein
[Thermotoga maritima]
Length = 321
Score = 76.1 bits (184), Expect = 8e-13
Identities = 44/131 (33%), Positives = 82/131 (62%), Gaps = 6/131 (4%)
Query: 79 NMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEK-VVG 137
++SI ++++ + + + F+ DVI ++P++T+ +M I G+PVV+++K VVG
Sbjct: 2 SVSIIDRLQAIFQDVRVSEFMNPDVIYVTPDKTLLHVKEIMRIKRISGVPVVDDKKRVVG 61
Query: 138 IISKKDIA-AREGKLVKEL----MTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGR 192
I+S +DI A EG +K+ MTK+V+ + E +++A+K + R PVVD EG+
Sbjct: 62 IVSLEDIIKALEGSYIKDSVEKRMTKNVVCLKETDTLQDAVKTFEKYGYGRFPVVDDEGK 121
Query: 193 LIGLITMSDLV 203
L+G++T D++
Sbjct: 122 LVGIVTKHDII 132
>sp|Q58069|Y653_METJA HYPOTHETICAL PROTEIN MJ0653 >gi|2128024|pir||E64381 conserved
hypothetical protein MJ0653 - Methanococcus jannaschii
>gi|1592300|gb|AAB98648.1| (U67513)
inosine-5'-monophosphate dehydrogenase (guaB)
[Methanococcus jannaschii]
Length = 194
Score = 75.7 bits (183), Expect = 1e-12
Identities = 38/94 (40%), Positives = 63/94 (66%), Gaps = 9/94 (9%)
Query: 118 LMEKHDIDGLPVVENEKVVGIISKKDIAAR--------EGKLVKELMTKDVITVPENIEV 169
+M +++I + +VEN K +GI++++DI R + L +E+M+K +IT+P+N +
Sbjct: 32 IMTENNIGAVVIVENNKPIGIVTERDIVKRVVSKNLKPKDVLAEEVMSKKIITIPQNASI 91
Query: 170 EEALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203
EA KIM + I RLPVV K+G L+G++T SD+V
Sbjct: 92 TEAAKIMATHGIKRLPVV-KDGELVGIVTQSDIV 124
>pir||B69077 yhcV homolog 2 - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2622697|gb|AAB86048.1| (AE000917)
inosine-5'-monophosphate dehydrogenase related protein X
[Methanobacterium thermoautotrophicum]
Length = 133
Score = 75.7 bits (183), Expect = 1e-12
Identities = 40/117 (34%), Positives = 71/117 (60%), Gaps = 5/117 (4%)
Query: 91 RVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIAAREGK 150
R +A ++ DVI P++ V A M + ++ G+PVVE +K+VG+I+ +DI G+
Sbjct: 11 RKLRARDIMLRDVIVSHPDDLVAAANLKMVRANVGGVPVVEGDKLVGLITHRDILLAGGE 70
Query: 151 L----VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203
VK++M++D++ + E + +IM + R+PVV ++GRL+GLIT S ++
Sbjct: 71 ALKLRVKDIMSQDLVVIDEETPISRISRIMADTGYQRIPVV-RDGRLVGLITQSCII 126
>pir||A70340 conserved hypothetical protein aq_438 - Aquifex aeolicus
>gi|2983115|gb|AAC06720.1| (AE000690) hypothetical
protein [Aquifex aeolicus]
Length = 319
Score = 75.3 bits (182), Expect = 1e-12
Identities = 45/112 (40%), Positives = 67/112 (59%), Gaps = 7/112 (6%)
Query: 98 FIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDI-----AAREGKLV 152
++ + IT+SP +T+ ++ KH I GLPVV K+VGI++K DI RE K V
Sbjct: 199 YMTPNPITVSPNQTLKEVEEILSKHLIGGLPVVAKGKLVGIVTKSDIQKVPSELREKKRV 258
Query: 153 KELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEG--RLIGLITMSDL 202
++M+ ++ITV E + E L+I I RLPVV +G LIG+IT +D+
Sbjct: 259 YDVMSTNLITVTEEESLAEVLRIFSSKGIGRLPVVKHKGSSELIGIITRADI 310
>pir||D69035 MJ1232 protein homolog MTH126 - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621166|gb|AAB84632.1| (AE000802)
inosine-5'-monophosphate dehydrogenase related protein
VII [Methanobacterium thermoautotrophicum]
Length = 302
Score = 74.9 bits (181), Expect = 2e-12
Identities = 39/116 (33%), Positives = 70/116 (59%), Gaps = 5/116 (4%)
Query: 93 KKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIAAR----- 147
K D++T++P+ TV A + I+G P+VE+++V GI++ DI A
Sbjct: 180 KTVAEVATRDLVTLAPDITVKEAAARLSSLGIEGAPIVEDDEVKGIVTLSDITASIAAGT 239
Query: 148 EGKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203
E V ++M+K++ITV ++ + +A+++M ++ I RL V D EGR G+IT +D++
Sbjct: 240 EFMQVSDIMSKNIITVKQDTMIADAIEVMNKHNIGRLIVTDSEGRPTGIITRTDIL 295
>gb|AAG19149.1| (AE005012) inosine-5'-monophosphate dehydrogenase; Imd1
[Halobacterium sp. NRC-1]
Length = 272
Score = 74.9 bits (181), Expect = 2e-12
Identities = 37/124 (29%), Positives = 76/124 (60%), Gaps = 2/124 (1%)
Query: 98 FIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIA-AREGKLVKELM 156
++ DV T+S ++TV + + D +G PV + V G +S +D+ A +L+ ++M
Sbjct: 18 YMTRDVATVSADDTVSDVAARISESDHNGFPVTDGRHVEGFVSARDLLLADPDELLFKVM 77
Query: 157 TKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAVRDEN 216
T+D++ ++V +A ++++ + I +LPVVD G L+G+IT +D++ R + + A ++
Sbjct: 78 TEDLVVAHPEMDVTDAARVILRSGIQKLPVVDDAGNLVGIITNADVI-RSQIERATPEKV 136
Query: 217 GELL 220
G+L+
Sbjct: 137 GKLM 140
>gi|11498786 conserved hypothetical protein [Archaeoglobus fulgidus]
>gi|7429347|pir||A69398 MJ0100 protein homolog AF1186 -
Archaeoglobus fulgidus >gi|2649397|gb|AAB90057.1|
(AE001022) conserved hypothetical protein [Archaeoglobus
fulgidus]
Length = 491
Score = 74.1 bits (179), Expect = 3e-12
Identities = 46/117 (39%), Positives = 69/117 (58%), Gaps = 4/117 (3%)
Query: 90 KRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIA---A 146
+R K + ++ + TISPE ++ A +M I+ +PVVE ++VGII+ DIA A
Sbjct: 369 QREVKVVKSVMVEAYTISPETAIEEAARIMMDKGINHIPVVEEGRLVGIITSWDIAKAVA 428
Query: 147 REGK-LVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDL 202
R K VK +MT++VI + VE A + M +N I LPVVD R++G++T DL
Sbjct: 429 RNRKGAVKSIMTRNVIYTHPDEPVEVAARKMEQNNISALPVVDSRKRVLGIVTSEDL 485
>gi|11497682 conserved hypothetical protein [Archaeoglobus fulgidus]
>gi|7429337|pir||F69257 MJ1225-related protein AF0062 -
Archaeoglobus fulgidus >gi|2650583|gb|AAB91162.1|
(AE001102) conserved hypothetical protein [Archaeoglobus
fulgidus]
Length = 296
Score = 73.4 bits (177), Expect = 5e-12
Identities = 45/136 (33%), Positives = 81/136 (59%), Gaps = 8/136 (5%)
Query: 94 KAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIAAR-EGKLV 152
KA + +VI + T D L L +K++I +PV++N ++VGI+++KDI + E +
Sbjct: 19 KAADIMNSNVIYATLPSTRDKVLELFKKYEISAVPVLKNSELVGIVTRKDILRKIEENQL 78
Query: 153 KELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARKKYKNAV 212
LMT + TV + +V+E +KI+ RLPVV K+G+L+G+IT+ D++ + +
Sbjct: 79 ALLMTPNPTTVDADADVKEVVKILTSTPFRRLPVV-KDGKLVGIITVRDIIKK------I 131
Query: 213 RDENGELLVAAAVSPF 228
+ N E V + ++P+
Sbjct: 132 AEMNIEKPVKSYITPY 147
>pir||C75148 hypothetical protein PAB2118 - Pyrococcus abyssi (strain Orsay)
>gi|5457776|emb|CAB49266.1| (AJ248284) hypothetical
protein [Pyrococcus abyssi]
Length = 282
Score = 73.0 bits (176), Expect = 7e-12
Identities = 43/123 (34%), Positives = 76/123 (60%), Gaps = 7/123 (5%)
Query: 94 KAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE-KVVGIISKKDIAAR-EGKL 151
K + + + +TI+ T ++AL + +KH + PVV E K+VGIIS K + + +
Sbjct: 2 KVKTIMTPNPVTITLPATRNYALDIFKKHKVRSFPVVNREGKLVGIISIKRVLTNPDEEQ 61
Query: 152 VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVAR-----K 206
+ L+ +DV TV EN ++++A ++M+E+ R+ VVD EG+ +G++T+ D+V R +
Sbjct: 62 LAMLVKRDVPTVKENDDLKKAARLMLEHDYRRVVVVDNEGKPVGILTVGDIVRRYLAKTE 121
Query: 207 KYK 209
KYK
Sbjct: 122 KYK 124
>sp|P54606|YHCV_BACSU HYPOTHETICAL 14.9 KD PROTEIN IN CSPB-GLPP INTERGENIC REGION
>gi|7429338|pir||B69824 conserved hypothetical protein
yhcV - Bacillus subtilis >gi|1239998|emb|CAA65706.1|
(X96983) hypothetical protein [Bacillus subtilis]
>gi|2633246|emb|CAB12751.1| (Z99108) similar to
hypothetical proteins [Bacillus subtilis]
Length = 140
Score = 72.2 bits (174), Expect = 1e-11
Identities = 36/111 (32%), Positives = 72/111 (64%), Gaps = 8/111 (7%)
Query: 103 VITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIA------AREGKL-VKEL 155
V T+SP +T+ A LM++H++ +PVVE + G+++ +DIA R+G+ V E+
Sbjct: 12 VATVSPNQTIQEAASLMKQHNVGAIPVVEQGVLKGMLTDRDIALRTTAQGRDGQTPVSEV 71
Query: 156 MTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVARK 206
M+ ++++ N+ +E+A ++M +++I RLP+VD + L+G++ + DL +
Sbjct: 72 MSTELVSGNPNMSLEDASQLMAQHQIRRLPIVD-QNNLVGIVALGDLAVNQ 121
>gi|11499010 chloride channel, putative [Archaeoglobus fulgidus]
>gi|7482945|pir||F69426 chloride channel, probable,
homolog - Archaeoglobus fulgidus
>gi|2649157|gb|AAB89832.1| (AE001006) chloride channel,
putative [Archaeoglobus fulgidus]
Length = 589
Score = 70.6 bits (170), Expect = 4e-11
Identities = 41/130 (31%), Positives = 81/130 (61%), Gaps = 8/130 (6%)
Query: 82 IEEQVEQVKRVKKAERFIVED-VITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIIS 140
+E ++ ++ V+ + + D ++ ++P + V L L+EK G PVV + ++VG+++
Sbjct: 448 MEMSIDVLENVRVQDAMVSADKLVVVTPYQRVSEVLELIEKTGHMGFPVVMDGRLVGMVT 507
Query: 141 KKDIAA-----REGKLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDK--EGRL 193
+D+ R+ KLV+++MT+++I + +EEAL +++ I RLPVVD+ E +L
Sbjct: 508 FEDVERVPLEERDKKLVRDIMTRELIVTYPDETLEEALIKLVDKGIGRLPVVDRNDEKKL 567
Query: 194 IGLITMSDLV 203
+G+IT SD++
Sbjct: 568 LGIITRSDIM 577
>pir||H75197 yhcV homolog PAB2277 - Pyrococcus abyssi (strain Orsay)
>gi|5457540|emb|CAB49031.1| (AJ248283)
INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE RELATED
[Pyrococcus abyssi]
Length = 136
Score = 70.2 bits (169), Expect = 5e-11
Identities = 44/128 (34%), Positives = 77/128 (59%), Gaps = 11/128 (8%)
Query: 98 FIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE-KVVGIISKKDIAARE-------G 149
++ + ++ + P+ TV A LM + D+ L VV++E VVG +K DI R
Sbjct: 10 YMTKKLMGVKPDTTVQEASKLMMEFDVGSLVVVDDEGNVVGFFTKSDIIRRVIVPGLSYD 69
Query: 150 KLVKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLV--ARKK 207
VKE+MTK++ITV N + + LK M E+RI + +++ EG+++G+ T+SDL+ +R++
Sbjct: 70 IPVKEIMTKELITVNANTPLGDVLKKMSEHRIKHI-LIEDEGKIVGIFTLSDLLEASRRR 128
Query: 208 YKNAVRDE 215
+ A+ E
Sbjct: 129 LETAISTE 136
>sp|Q57647|Y188_METJA HYPOTHETICAL PROTEIN MJ0188 >gi|2128173|pir||E64323 conserved
hypothetical protein MJ0188 - Methanococcus jannaschii
>gi|1498962|gb|AAB98168.1| (U67475)
inosine-5'-monophosphate dehydrogenase, putative
[Methanococcus jannaschii]
Length = 265
Score = 69.9 bits (168), Expect = 6e-11
Identities = 35/113 (30%), Positives = 67/113 (58%), Gaps = 3/113 (2%)
Query: 94 KAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENEKVVGIISKKDIAAR-EGKLV 152
K ++ + V+T+S + TV + L+++ + PVVEN K++GI+S DI + + + V
Sbjct: 4 KVSEYMTKKVVTVSKDNTVKDVIKLLKETGHNSFPVVENGKLIGIVSVHDIVGKDDNEKV 63
Query: 153 KELMT--KDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203
+ +MT KD++ + + + +IM +LPVVD+E L+G+I+ D++
Sbjct: 64 ENVMTKRKDMVVTTPDANIMDVGRIMFRTGFSKLPVVDEENNLVGIISNMDVI 116
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.317 0.137 0.377
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 171161098
Number of Sequences: 2977
Number of extensions: 7217646
Number of successful extensions: 21872
Number of sequences better than 1.0e-10: 123
Number of HSP's better than 0.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 21274
Number of HSP's gapped (non-prelim): 176
length of query: 485
length of database: 189,106,746
effective HSP length: 60
effective length of query: 425
effective length of database: 153,197,526
effective search space: 65108948550
effective search space used: 65108948550
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 167 (69.5 bits)