BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1271 (purD) DE:phosphoribosylamine--glycine ligase (purD)
(438 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UY71|PUR2_PYRAB PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 883 0.0
sp|O58061|PUR2_PYRHO PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 748 0.0
sp|Q58347|PUR2_METJA PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 467 e-130
pir||D69059 glycinamide ribonucleotide synthetase - Methanobacte... 451 e-126
sp|O27494|PUR2_METTH PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 451 e-126
gb|AAG19650.1| (AE005053) phosphoribosylglycinamide synthetase; ... 299 5e-80
emb|CAB57666.1| (Y18930) phosphoribosylamine-glycine ligase (GAR... 286 5e-76
gb|AAK40943.1| Phosphoribosylamine--glycine ligase (GAR syntheta... 286 5e-76
dbj|BAB04353.1| (AP001509) phosphoribosylglycinamide synthetase ... 243 3e-63
sp|O66949|PUR2_AQUAE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 243 4e-63
gb|AAB60737.1| (AC000132) Identical to A. thaliana PUR2 (gb|X747... 231 1e-59
pir||E75397 phosphoribosylamine--glycine ligase - Deinococcus ra... 230 3e-59
sp|P12039|PUR2_BACSU PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 224 2e-57
pir||B82344 phosphoribosylamine--glycine ligase VC0275 [imported... 223 3e-57
gi|4503915 phosphoribosylglycinamide formyltransferase, phosphor... 220 2e-56
dbj|BAA06809.1| (D32051) GARS protein [Homo sapiens] 219 5e-56
pir||S37104 phosphoribosylamine--glycine ligase (EC 6.3.4.13) - ... 217 2e-55
sp|P52420|PUR2_ARATH PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PRECURS... 217 2e-55
sp|P21872|PUR2_CHICK TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 216 3e-55
sp|P20772|PUR2_SCHPO BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN AD... 215 6e-55
gb|AAF71749.1| (AF257743) phosphoribosylglycinamide formyltransf... 213 3e-54
gb|AAC96120.1| (AF083221) glycinamide ribonucleotide transformyl... 213 4e-54
pir||F83038 phosphoribosylamine--glycine ligase PA4855 [imported... 213 4e-54
sp|P26977|PUR2_SALTY PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 212 5e-54
pir||T46882 phosphoribosylamine--glycine ligase (EC 6.3.4.13) [i... 211 1e-53
pir||I67805 purine synthesis multifunctional protein - mouse >gi... 211 1e-53
gb|AAC53250.1| (U20892) glycinamide ribonucleotide synthetase [M... 211 2e-53
gi|6857793 phosphoribosylglycinamide formyltransferase [Mus musc... 211 2e-53
sp|P43845|PUR2_HAEIN PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 210 2e-53
dbj|BAA89446.1| (AB003161) 5'-phosphoribosylglycinamide syntheta... 209 4e-53
sp|Q9ZF44|PUR2_LACLA PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 209 6e-53
sp|P15640|PUR2_ECOLI PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 209 6e-53
gb|AAA24455.1| (J05126) purD (EC 6.3.4.13) [Escherichia coli] 206 4e-52
pir||E81000 phosphoribosylamine--glycine ligase NMB2151 [importe... 206 4e-52
gb|AAG02154.1|AF212041_10 (AF212041) phosphoribosylamine-glycine... 206 4e-52
pdb|1GSO|A Chain A, Glycinamide Ribonucleotide Synthetase (Gar-S... 205 9e-52
pir||B82018 phosphoribosylamine--glycine ligase (EC 6.3.4.13) NM... 205 9e-52
pir||D82614 glycinamide ribonucleotide synthetase XF1976 [import... 199 7e-50
sp|Q50144|PUR2_MYCLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 197 2e-49
sp|P00967|PUR2_DROME TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 194 1e-48
gb|AAF52474.1| (AE003615) ade3 gene product [Drosophila melanoga... 194 1e-48
gb|AAA28562.1| (J02527) Gart polypeptide 1.7 kb transcript [Dros... 194 2e-48
sp|P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 193 3e-48
sp|Q99148|PUR2_YARLI BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN AD... 192 5e-48
emb|CAB56348.1| (AL118514) phosphoribosylamine-glycine ligase (E... 192 8e-48
gb|AAG09178.1| (AF174494) purine biosynthetic pathway protein AD... 188 1e-46
sp|Q26255|PUR2_CHITE TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 183 3e-45
sp|Q9X0X7|PUR2_THEMA PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 182 7e-45
sp|P74232|PUR2_SYNY3 PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 181 1e-44
emb|CAC11734.1| (AL445064) phosphoribosylamide-glycine ligase re... 181 2e-44
gi|11498757 phosphoribosylamine--glycine ligase (purD) [Archaeog... 179 5e-44
sp|P71827|PUR2_MYCTU PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 179 5e-44
emb|CAA24923.1| (X00041) GART [Drosophila melanogaster] 173 4e-42
pir||D81332 phosphoribosylamine--glycine ligase (EC 6.3.4.13) Cj... 173 4e-42
gi|6321203 glycinamide ribotide synthetase and aminoimidazole ri... 168 1e-40
pir||T07778 phosphoribosylamine--glycine ligase (EC 6.3.4.13) - ... 162 9e-39
pir||T16297 hypothetical protein F38B6.4 - Caenorhabditis elegan... 150 4e-35
emb|CAA52778.2| (X74766) glycinamide ribonucleotide synthetase [... 146 4e-34
emb|CAC11733.1| (AL445064) phosphoribosylamide-glycine ligase re... 141 2e-32
sp|Q9ZK07|PUR2_HELPJ PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 139 4e-32
sp|P52421|PUR2_VIGUN PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 139 6e-32
sp|O25817|PUR2_HELPY PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 137 3e-31
sp|Q46482|PUR2_CHRVI PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) ... 104 2e-21
pir||S54423 phosphoribosylamine--glycine ligase (EC 6.3.4.13) - ... 77 4e-13
>sp|Q9UY71|PUR2_PYRAB PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438044|pir||G75012
phosphoribosylamine--glycine ligase (purd) PAB1271 -
Pyrococcus abyssi (strain Orsay)
>gi|5459055|emb|CAB50541.1| (AJ248288)
phosphoribosylamine--glycine ligase (purD) [Pyrococcus
abyssi]
Length = 438
Score = 883 bits (2258), Expect = 0.0
Identities = 438/438 (100%), Positives = 438/438 (100%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR
Sbjct: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK
Sbjct: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG 180
LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG
Sbjct: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG 180
Query: 181 KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF
Sbjct: 181 KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
Query: 241 ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAINVL 300
ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAINVL
Sbjct: 241 ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAINVL 300
Query: 301 SILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAIKEEG 360
SILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAIKEEG
Sbjct: 301 SILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAIKEEG 360
Query: 361 AKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDVGTKESIE 420
AKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDVGTKESIE
Sbjct: 361 AKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDVGTKESIE 420
Query: 421 KRIRTMKELGKEFEPNSC 438
KRIRTMKELGKEFEPNSC
Sbjct: 421 KRIRTMKELGKEFEPNSC 438
>sp|O58061|PUR2_PYRHO PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438042|pir||H71138 probable
phosphoribosylamide--glycine ligase - Pyrococcus
horikoshii >gi|3256714|dbj|BAA29397.1| (AP000002) 438aa
long hypothetical phosphoribosylamide--glycine ligase
[Pyrococcus horikoshii]
Length = 438
Score = 748 bits (1911), Expect = 0.0
Identities = 351/438 (80%), Positives = 409/438 (93%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M+VLLVGGGGREHAIGEAL +GGAELYVVS H+NPGL R+++DYG++KET+VE V++FAR
Sbjct: 1 MKVLLVGGGGREHAIGEALVKGGAELYVVSNHRNPGLMRLAKDYGLAKETNVEDVIKFAR 60
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
W ++LAFIGPEAPLEAGIVNALE EGIP VGPT+EAARLETNKAWAREFMERN+IPGRK
Sbjct: 61 KWGIELAFIGPEAPLEAGIVNALEEEGIPAVGPTREAARLETNKAWAREFMERNNIPGRK 120
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG 180
+F++FDDV+EM+ WIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAE++I+KDG
Sbjct: 121 MFRIFDDVQEMRKWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEHIIRKDG 180
Query: 181 KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
KVLIEERTDGVEFT QVF+DG+ VIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH+LPF
Sbjct: 181 KVLIEERTDGVEFTLQVFTDGKKVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHLLPF 240
Query: 241 ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAINVL 300
IT+ D++ AL+TLEETI+AMRKEGYPYKGILYGQFMLS EGPV+IEYNARFGDPEAINVL
Sbjct: 241 ITEGDFERALKTLEETIEAMRKEGYPYKGILYGQFMLSGEGPVLIEYNARFGDPEAINVL 300
Query: 301 SILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAIKEEG 360
++L+DNL+EIA+GIV+G +R AKF KATVVKY+AP+GYP++PI+G I V+EE IK EG
Sbjct: 301 AVLDDNLLEIAKGIVEGSLRKAKFLNKATVVKYIAPQGYPQDPIKGIRIEVDEEGIKNEG 360
Query: 361 AKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDVGTKESIE 420
AKI+YA+VDEN+ LLGSRALA+VGVAD+LEEAE+IAE G+ +V+GP+FYRKDVGT+ES+E
Sbjct: 361 AKIIYAAVDENLTLLGSRALAIVGVADSLEEAERIAENGVSYVKGPIFYRKDVGTRESVE 420
Query: 421 KRIRTMKELGKEFEPNSC 438
KRI MK+LGKEFEPN C
Sbjct: 421 KRIEIMKKLGKEFEPNLC 438
>sp|Q58347|PUR2_METJA PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|2144567|pir||A64417
phosphoribosylamine--glycine ligase (EC 6.3.4.13) -
Methanococcus jannaschii >gi|1499772|gb|AAB98942.1|
(U67537) phosphoribosylamine--glycine ligase (purD)
[Methanococcus jannaschii]
Length = 444
Score = 467 bits (1188), Expect = e-130
Identities = 241/442 (54%), Positives = 326/442 (73%), Gaps = 13/442 (2%)
Query: 1 MRVLLVGGGGREHAIGEALARGG-AELYVVSKHKNPGLARISRDYGISKETDVEKVVRFA 59
M++LL+GGG RE AI AL + +LY + K+KNPG+AR+S + ++KETD++ V FA
Sbjct: 1 MKILLIGGGARESAIAHALKKNEEVKLYTLMKNKNPGIARLSEEIKLAKETDLDAVKEFA 60
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
DLA IGPEAPL G+V+ LE GI VGP K AA++ETNK + R ++ +I G
Sbjct: 61 EKVKPDLAVIGPEAPLGEGVVDLLEEMGISAVGPKKLAAQIETNKEFMRNLFKKYNIKGS 120
Query: 120 KLFKVFDDV-EEMKAWIDEY---GKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYL 175
++K F++ EE++++IDE G VVKP+GLTGGKGVKVVG QLKDNEEAK+YA+ +
Sbjct: 121 LMYKAFEEYGEELESFIDELTEKGIKAVVKPVGLTGGKGVKVVGEQLKDNEEAKKYAKEI 180
Query: 176 IKKD---GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYS 232
+ GKVLIEE+ +GVEFT F DG + P VQD+PHA EGD G ITGGMGSYS
Sbjct: 181 FETGLGGGKVLIEEKLEGVEFTLHGFVDGDTIKFTPFVQDHPHALEGDEGSITGGMGSYS 240
Query: 233 CSNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFG 292
C +H LPF+T+ED K+A +EET+KA+++E YKGILYGQFML++EGP IIEYNARFG
Sbjct: 241 CPDHKLPFMTEEDVKLAKEIMEETVKALKEEVGGYKGILYGQFMLTKEGPKIIEYNARFG 300
Query: 293 DPEAINVLSILEDNLVEIAEGIVKGRVR--GAKFQEKATVVKYLAPKGYPENPIRGAEIM 350
DPEA+N+L+IL+++ +E+ E IV +++ +F+ KATV KY+ PKGYP+NP+RG I
Sbjct: 301 DPEAMNLLAILKNDFLEVCEAIVNKKLKDIDVEFENKATVCKYVVPKGYPDNPVRGEPIT 360
Query: 351 VNEEAIKEEGAKIVYASVDE---NMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPV 407
V+EEAIK+ GA + YASV+E ++ + GSRA+A+VGVADT+EEAE+IAE ++++G V
Sbjct: 361 VDEEAIKKTGAILHYASVNEDNGSLYMTGSRAVAVVGVADTIEEAERIAEEATKYIKGEV 420
Query: 408 FYRKDVGTKESIEKRIRTMKEL 429
++R D+G KE I+KRI M EL
Sbjct: 421 YHRSDIGKKELIKKRIEKMNEL 442
>pir||D69059 glycinamide ribonucleotide synthetase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622558|gb|AAB85920.1| (AE000906) glycinamide
ribonucleotide synthetase [Methanobacterium
thermoautotrophicum]
Length = 457
Score = 451 bits (1147), Expect = e-126
Identities = 228/436 (52%), Positives = 320/436 (73%), Gaps = 9/436 (2%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M++L+VG G REHAI ALA A +Y V ++NPG++R++ + + + KVVRFA
Sbjct: 22 MKILVVGTGAREHAICSALA-DEATIYSVMGNRNPGISRLAGNSLLLLKL-TPKVVRFAS 79
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
VD+AFIGPEA LEAG+V+ALE GIP+VGPT++AAR+ET+K++ R+ E IPG
Sbjct: 80 EKGVDMAFIGPEAHLEAGLVDALEEAGIPSVGPTRDAARIETDKSFMRKLFEDYRIPGSI 139
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKK-- 178
++VF D EE++ +++++ VVKP+GLTGGKGVK+VG L+DN EA +YA +I+K
Sbjct: 140 TYRVFSDPEELREFMEDFDSEAVVKPVGLTGGKGVKIVGEHLRDNMEALKYATEVIEKRI 199
Query: 179 --DGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
V+IEER G EFT Q FSDG +++PMP VQD+PHAYEGD GPITGGMGSYS S+
Sbjct: 200 GGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAYEGDQGPITGGMGSYSDSDG 259
Query: 237 ILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEA 296
+LPF+T++D++ A+ ++ T+ A+RKE PY+GILYGQFMLS +GP +IEYNARFGDPEA
Sbjct: 260 LLPFLTQKDYEDAVEIMQRTVDAIRKETGPYRGILYGQFMLSADGPKLIEYNARFGDPEA 319
Query: 297 INVLSILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAI 356
+NVL +LE +++EI EGIV G ++ A F ATV KYL P+GYPE+ + GAEI V+E+ I
Sbjct: 320 MNVLPLLESSMLEICEGIVDGNLKSASFMNLATVCKYLVPEGYPESGVAGAEIKVDEKKI 379
Query: 357 KEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDV 413
++ G YA+V D+++ SRALA+V AD + AE++ E HV+G +++R+D+
Sbjct: 380 EDMGVITYYAAVNQEDDHIYTSSSRALALVAPADDIYSAEELCEEATAHVKGRLYHRRDI 439
Query: 414 GTKESIEKRIRTMKEL 429
GT+E +EKRI+ M++L
Sbjct: 440 GTRELVEKRIKHMEDL 455
>sp|O27494|PUR2_METTH PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE)
Length = 436
Score = 451 bits (1147), Expect = e-126
Identities = 228/436 (52%), Positives = 320/436 (73%), Gaps = 9/436 (2%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M++L+VG G REHAI ALA A +Y V ++NPG++R++ + + + KVVRFA
Sbjct: 1 MKILVVGTGAREHAICSALA-DEATIYSVMGNRNPGISRLAGNSLLLLKL-TPKVVRFAS 58
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
VD+AFIGPEA LEAG+V+ALE GIP+VGPT++AAR+ET+K++ R+ E IPG
Sbjct: 59 EKGVDMAFIGPEAHLEAGLVDALEEAGIPSVGPTRDAARIETDKSFMRKLFEDYRIPGSI 118
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKK-- 178
++VF D EE++ +++++ VVKP+GLTGGKGVK+VG L+DN EA +YA +I+K
Sbjct: 119 TYRVFSDPEELREFMEDFDSEAVVKPVGLTGGKGVKIVGEHLRDNMEALKYATEVIEKRI 178
Query: 179 --DGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
V+IEER G EFT Q FSDG +++PMP VQD+PHAYEGD GPITGGMGSYS S+
Sbjct: 179 GGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAYEGDQGPITGGMGSYSDSDG 238
Query: 237 ILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEA 296
+LPF+T++D++ A+ ++ T+ A+RKE PY+GILYGQFMLS +GP +IEYNARFGDPEA
Sbjct: 239 LLPFLTQKDYEDAVEIMQRTVDAIRKETGPYRGILYGQFMLSADGPKLIEYNARFGDPEA 298
Query: 297 INVLSILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAI 356
+NVL +LE +++EI EGIV G ++ A F ATV KYL P+GYPE+ + GAEI V+E+ I
Sbjct: 299 MNVLPLLESSMLEICEGIVDGNLKSASFMNLATVCKYLVPEGYPESGVAGAEIKVDEKKI 358
Query: 357 KEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDV 413
++ G YA+V D+++ SRALA+V AD + AE++ E HV+G +++R+D+
Sbjct: 359 EDMGVITYYAAVNQEDDHIYTSSSRALALVAPADDIYSAEELCEEATAHVKGRLYHRRDI 418
Query: 414 GTKESIEKRIRTMKEL 429
GT+E +EKRI+ M++L
Sbjct: 419 GTRELVEKRIKHMEDL 434
>gb|AAG19650.1| (AE005053) phosphoribosylglycinamide synthetase; PurD
[Halobacterium sp. NRC-1]
Length = 430
Score = 299 bits (757), Expect = 5e-80
Identities = 172/434 (39%), Positives = 247/434 (56%), Gaps = 17/434 (3%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFARM 61
RVLL+GGGGREHA+ +ALA LY + +NPG+ ++ D I D VV A
Sbjct: 4 RVLLLGGGGREHALADALA-DDCTLYAAASTRNPGIDALADDLTILNPADPAAVVDHATA 62
Query: 62 WNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRKL 121
+ L +GPEAPL AG+V+AL GI GPT+ AR+ET+K + REFM ND+PG+
Sbjct: 63 IDATLVVVGPEAPLAAGVVDALSDAGIYAFGPTQADARIETDKQFQREFMAANDVPGQAD 122
Query: 122 FKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD-G 180
F+ FDD + ++ V VKP GLTGGKGV+V G QL A+Y+ D
Sbjct: 123 FETFDDSDAAADYVTGVDGHVAVKPAGLTGGKGVRVTGDQL----SKPAAADYIRTSDHD 178
Query: 181 KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
+IEER DGVE T Q ++ P+V D+ AYEGD GP TGGMGS + ++PF
Sbjct: 179 DWVIEERLDGVEITVQALVANGDIRTTPVVHDHGRAYEGDDGPNTGGMGSIAGPGRLVPF 238
Query: 241 ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAINVL 300
T D++ A+ T+ + + Y+G+LYGQFML+ +GP ++E+NARFGDPEA+N L
Sbjct: 239 ATDADYQAAVDTIRAVVDGLE----DYRGVLYGQFMLTADGPKVVEFNARFGDPEAMNTL 294
Query: 301 SILEDNLVEIAEGIVKGR-VRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAIKEE 359
+ +E L+++ G + F E ATV Y P GYP +P G I +++ + +
Sbjct: 295 TTMETPLLDVLAAARDGEALPELAFSEPATVCTYAVPDGYPTDPTGGTTITIDDASTGD- 353
Query: 360 GAKIVYASVDE----NMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDVGT 415
A++ YASVD ++ SR+ A+VG D++ A +A + + V R+D+G+
Sbjct: 354 -AELFYASVDAHDDGSLTTTTSRSFAVVGTGDSIPAAATSVDAALADLPDGVRVRRDIGS 412
Query: 416 KESIEKRIRTMKEL 429
K + R M+ L
Sbjct: 413 KTLLADRNARMRRL 426
>emb|CAB57666.1| (Y18930) phosphoribosylamine-glycine ligase (GARS), (glycinamide
ribonucleotide synthetase) [Sulfolobus solfataricus]
Length = 483
Score = 286 bits (723), Expect = 5e-76
Identities = 181/450 (40%), Positives = 260/450 (57%), Gaps = 30/450 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARG--GAELYVVSKHKNPGLARISR----DYGISKETDVEK 54
M+VLLVG G RE+ + +LAR G ++Y +S + NPG+ I + +Y I E
Sbjct: 5 MKVLLVGDGARENVLAYSLARSSKGYKIYALSSYINPGINSIVKTTGAEYFIGNVNSPEV 64
Query: 55 VVRFARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERN 114
+ + N DL IGPE PL GI + +EGI G +K+ AR+E +KAWARE M ++
Sbjct: 65 IKEVIKKVNPDLGVIGPEDPLFNGIADIFRKEGISVFGASKKCARIEESKAWARELMWKH 124
Query: 115 DIPGRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVV----GYQLKDNEEA-- 168
IPGR +KVF +E+ +I EYG V +KP G GGKGVKV+ Y D EA
Sbjct: 125 SIPGRLRYKVFYTIEDTAKFILEYGGSVAIKPAGQAGGKGVKVIADLEAYLTHDKREALT 184
Query: 169 KEYAEY--LIKKDG--KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPI 224
K E L K+G +++IEE+ DG E+T V SDG+ I +PL QDY +AY+ +GP
Sbjct: 185 KSVNEIGSLYNKEGEPRIIIEEKVDGPEYTLHVLSDGKTTISLPLAQDYKNAYQDGIGPE 244
Query: 225 TGGMGSYSCSNHILPFITKEDWKMALRTLEETIKAMRKE-GYPYKGILYGQFMLSR-EGP 282
TGGMGS S N +LPFI+ E+++ ++ T+ A+ KE G Y G++ GQ ML+ GP
Sbjct: 245 TGGMGSISGPNELLPFISNEEYQTTYDIVKRTMDAIYKETGERYVGVIAGQMMLTELWGP 304
Query: 283 VIIEYNARFGDPEAINVLSILEDNLVEIAEGIVKGRVRGA--KFQEKATVVKYLAPKGYP 340
+IEY +RFGDPEA ++ LE + E E G + A K EK ++V+ +A GYP
Sbjct: 305 TVIEYYSRFGDPEASAIIPRLESDFGETIELTATGHLNKASIKINEKPSIVRAVATLGYP 364
Query: 341 --ENPIRGAEIMVNEEAIKEEGAKIVYASVD-ENMKLL--GSRALAMVGVADTLEEAEKI 395
+ G +I+V+ E +KE G + + SV E M+L+ GSRAL +V + D EEA +
Sbjct: 365 ISKQMASGHKIVVDLEKMKERGCVVFFGSVALEGMQLITKGSRALEIVAIGD-FEEAAEN 423
Query: 396 AEAGIRHVRG--PVFYRKDVG--TKESIEK 421
+ ++++ + YR D+G K IEK
Sbjct: 424 LDRCMQYISSDTKLIYRTDIGRTVKSQIEK 453
>gb|AAK40943.1| Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD)
[Sulfolobus solfataricus]
Length = 483
Score = 286 bits (723), Expect = 5e-76
Identities = 181/450 (40%), Positives = 260/450 (57%), Gaps = 30/450 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARG--GAELYVVSKHKNPGLARISR----DYGISKETDVEK 54
M+VLLVG G RE+ + +LAR G ++Y +S + NPG+ I + +Y I E
Sbjct: 5 MKVLLVGDGARENVLAYSLARSSKGYKIYALSSYINPGINSIVKTTGAEYFIGNVNSPEV 64
Query: 55 VVRFARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERN 114
+ + N DL IGPE PL GI + +EGI G +K+ AR+E +KAWARE M ++
Sbjct: 65 IKEVIKKVNPDLGVIGPEDPLFNGIADIFRKEGISVFGASKKCARIEESKAWARELMWKH 124
Query: 115 DIPGRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVV----GYQLKDNEEA-- 168
IPGR +KVF +E+ +I EYG V +KP G GGKGVKV+ Y D EA
Sbjct: 125 SIPGRLRYKVFYTIEDTAKFILEYGGSVAIKPAGQAGGKGVKVIADLEAYLTHDKREALT 184
Query: 169 KEYAEY--LIKKDG--KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPI 224
K E L K+G +++IEE+ DG E+T V SDG+ I +PL QDY +AY+ +GP
Sbjct: 185 KSVNEIGSLYNKEGEPRIIIEEKVDGPEYTLHVLSDGKTTISLPLAQDYKNAYQDGIGPE 244
Query: 225 TGGMGSYSCSNHILPFITKEDWKMALRTLEETIKAMRKE-GYPYKGILYGQFMLSR-EGP 282
TGGMGS S N +LPFI+ E+++ ++ T+ A+ KE G Y G++ GQ ML+ GP
Sbjct: 245 TGGMGSISGPNELLPFISNEEYQTTYDIVKRTMDAIYKETGERYVGVIAGQMMLTELWGP 304
Query: 283 VIIEYNARFGDPEAINVLSILEDNLVEIAEGIVKGRVRGA--KFQEKATVVKYLAPKGYP 340
+IEY +RFGDPEA ++ LE + E E G + A K EK ++V+ +A GYP
Sbjct: 305 TVIEYYSRFGDPEASAIIPRLESDFGETIELTATGHLNKASIKINEKPSIVRAVATLGYP 364
Query: 341 --ENPIRGAEIMVNEEAIKEEGAKIVYASVD-ENMKLL--GSRALAMVGVADTLEEAEKI 395
+ G +I+V+ E +KE G + + SV E M+L+ GSRAL +V + D EEA +
Sbjct: 365 ISKQMASGHKIVVDLEKMKERGCVVFFGSVALEGMQLITKGSRALEIVAIGD-FEEAAEN 423
Query: 396 AEAGIRHVRG--PVFYRKDVG--TKESIEK 421
+ ++++ + YR D+G K IEK
Sbjct: 424 LDRCMQYISSDTKLIYRTDIGRTVKSQIEK 453
>dbj|BAB04353.1| (AP001509) phosphoribosylglycinamide synthetase [Bacillus
halodurans]
Length = 428
Score = 243 bits (614), Expect = 3e-63
Identities = 155/439 (35%), Positives = 240/439 (54%), Gaps = 23/439 (5%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M VL++G GGREH I A+ V N G++ ++ IS E D +++V FA+
Sbjct: 1 MNVLVIGSGGREHTIAWKFAQSEKVERVYVAPGNDGMSDVATCVAIS-EQDHDQLVAFAK 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
+ L F+GPE PL AGIV+ + EG+ GP+K AA +E +K++A++ M+ +IP
Sbjct: 60 ENKIGLTFVGPEVPLLAGIVDRFQEEGLRVFGPSKRAAEIEGSKSYAKQVMKTYNIPTGS 119
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD- 179
++VF +E KA+++ G P+V+K GL GKGV V NEEA + ++ +D
Sbjct: 120 -YEVFTSFDEAKAYVEAEGVPIVIKADGLAAGKGVVVA----LTNEEAIAALDDMLNQDK 174
Query: 180 -----GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
+V+IEE +G E + F G VIPM QD+ A++GD GP TGGMG+YS
Sbjct: 175 FGGAGARVVIEEYLEGEELSLMAFVHGETVIPMVGAQDHKRAFDGDQGPNTGGMGAYSP- 233
Query: 235 NHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
+P + K A+ L T +A+ +E + GILY M++ +GP +IE+NARFGD
Sbjct: 234 ---VPQFSDVQLKQAVNEILIPTARALMQEERSFTGILYAGLMMTADGPKVIEFNARFGD 290
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNE 353
PE VL L+ +LV + E ++ G+ ++ E+A + LA KGYP + +G I E
Sbjct: 291 PETQVVLPRLKSDLVNVIESLLDGQEPELEWDEQAVLGVVLATKGYPGSYEKGYTISGLE 350
Query: 354 EAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGP-VFY 409
+ E+ + +A +E + G R L + A TL EA+ + V+ +FY
Sbjct: 351 QL--EDDTLVFHAGTKREEEELVTNGGRVLLVAKQASTLREAQAAVYEELNKVKSDGLFY 408
Query: 410 RKDVGTKESIEKRIRTMKE 428
RKD+G+K E+ + + E
Sbjct: 409 RKDIGSKAIAERAVSSQTE 427
>sp|O66949|PUR2_AQUAE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438040|pir||B70365
phosphoribosylamine-glycine ligase - Aquifex aeolicus
>gi|2983317|gb|AAC06907.1| (AE000705)
phosphoribosylamine-glycine ligase [Aquifex aeolicus]
Length = 424
Score = 243 bits (613), Expect = 4e-63
Identities = 156/425 (36%), Positives = 234/425 (54%), Gaps = 17/425 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGA--ELYVVSKHKNPGLARISRDYGISKETDVEKVVRF 58
M+VL+VG GGREHAI +A+ ELYV N G+ I++ IS TDVEK+ F
Sbjct: 1 MKVLVVGNGGREHAIAWKVAQSPLVKELYVAKG--NAGIWEIAKRVDISP-TDVEKLAEF 57
Query: 59 ARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPG 118
A+ VD +GPEAPL GIV+ E+ G+ GP KEAA+LE +KA+A+ FM++ IP
Sbjct: 58 AKNEGVDFTIVGPEAPLVEGIVDEFEKRGLKIFGPNKEAAKLEGSKAFAKTFMKKYGIPT 117
Query: 119 RKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI-- 176
+ ++VF D E+ K ++++ G P+VVK GL GKG V K E + I
Sbjct: 118 AR-YEVFTDFEKAKEYVEKVGAPIVVKADGLAAGKGAVVCETVEKAIETLDRFLNKKIFG 176
Query: 177 KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
K +V+IEE +G E ++ V +G +P+P QD+ + D GP TGGMG+YS +
Sbjct: 177 KSSERVVIEEFLEGEEASYIVMINGDRYVPLPTSQDHKRLLDEDKGPNTGGMGAYSPT-- 234
Query: 237 ILPFITKE-DWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPE 295
P I +E + ++ +E IK +++EG Y+G LY M+++EGP ++E+N R GDPE
Sbjct: 235 --PVINEEVEKRIREEIVERVIKGLKEEGIYYRGFLYAGLMITKEGPKVLEFNVRLGDPE 292
Query: 296 AINVLSILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEA 355
A +L ++++ +E +G+ K E+ + LA +GYPE P G I +
Sbjct: 293 AQPILMRVKNDFLETLLNFYEGKDVHIKEDERYALDVVLASRGYPEKPETGKIIHGLDYL 352
Query: 356 IKEEGAKIVYASVDENMKLL---GSRALAMVGVADTLEEAEKIAEAGIRHV-RGPVFYRK 411
E + +A + G R L + TL+EA++ A IR+V + YRK
Sbjct: 353 KSMEDVVVFHAGTKKEGNFTVTSGGRVLNVCAYGKTLKEAKERAYEAIRYVCFEGMHYRK 412
Query: 412 DVGTK 416
D+G K
Sbjct: 413 DIGDK 417
>gb|AAB60737.1| (AC000132) Identical to A. thaliana PUR2 (gb|X74766). ESTs
gb|ATTS3927,gb|N96446 come from this gene. [Arabidopsis
thaliana]
Length = 532
Score = 231 bits (583), Expect = 1e-59
Identities = 151/448 (33%), Positives = 237/448 (52%), Gaps = 30/448 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEK---VVR 57
+ VL++GGGGREHA+ AL R + V+ N G++ S D + D+ V+
Sbjct: 95 VNVLVIGGGGREHALCHALKRSPSCDSVLCAPGNAGISS-SGDATCVPDLDISDSLAVIS 153
Query: 58 FARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIP 117
F + WNV L +GPE PL AG+ N L + GI T GP+ +AA LE +K + + + +IP
Sbjct: 154 FCQKWNVGLVVVGPEVPLVAGLANDLVKAGILTFGPSSQAAALEGSKNFMKNLCHKYNIP 213
Query: 118 GRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIK 177
K +K F D K +I E G P+V+K GL GKGV V + EEA E + ++
Sbjct: 214 TAK-YKTFSDASAAKEYIQEQGAPIVIKADGLAAGKGVTVA----MELEEAFEAVDSMLV 268
Query: 178 K------DGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY 231
K +V++EE +G E +F DG N IP+ QD+ +GD GP TGGMG+Y
Sbjct: 269 KGVFGSAGCQVVVEEFLEGEEASFFALVDGENAIPLESAQDHKRVGDGDTGPNTGGMGAY 328
Query: 232 SCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREG--PVIIEYN 288
S + P +TKE + + + T+K M +EG + G+L+ M+ ++ P +IE+N
Sbjct: 329 SPA----PVLTKELQDFVMESIIHPTVKGMAEEGCKFVGVLFAGLMIEKKSGLPKLIEFN 384
Query: 289 ARFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAK--FQEKATVVKYLAPKGYPENPIRG 346
RFGDPE ++ LE +L ++ KG + G + + + +V +A GYP + +G
Sbjct: 385 VRFGDPECQVLMMRLESDLAKVLLAACKGELSGVSLDWSKDSAMVVVMASNGYPGSYEKG 444
Query: 347 AEIMVNEEAIK-EEGAKIVYASV----DENMKLLGSRALAMVGVADTLEEAEKIAEAGIR 401
+ I EEA + G K+ +A + N+ G R L + LEEA + A + ++
Sbjct: 445 SIIKNLEEAERVAPGVKVFHAGTGLDSEGNVVATGGRVLGVTAKGKDLEEARERAYSAVQ 504
Query: 402 HVRGP-VFYRKDVGTKESIEKRIRTMKE 428
+ P F+R D+G + +K++ T +E
Sbjct: 505 QINWPGGFFRHDIGWRALRQKQVATKEE 532
>pir||E75397 phosphoribosylamine--glycine ligase - Deinococcus radiodurans
(strain R1) >gi|6459187|gb|AAF10999.1|AE001987_7
(AE001987) phosphoribosylamine--glycine ligase
[Deinococcus radiodurans]
Length = 458
Score = 230 bits (580), Expect = 3e-59
Identities = 145/399 (36%), Positives = 222/399 (55%), Gaps = 24/399 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M+VL++G GGREHAI +A AR G E V+ NPG+A +R ++ D + A
Sbjct: 44 MKVLVIGSGGREHAIVDACARAGHE--VLCTPGNPGIAAQARL--LASPQDAPTLADLAV 99
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
D+ +GPEA L AG+V+ ER G+P GP++ A+RLE +KAW++ FM R+ IP +
Sbjct: 100 REGADVVIVGPEAYLAAGVVDECERRGVPAFGPSQAASRLEGDKAWSKAFMVRHGIPTAQ 159
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG 180
+ FD ++ + P+VVK GL GKGV + + + + E A E +
Sbjct: 160 -HRSFDTLDAALSHAATQTPPIVVKDAGLKAGKGV-TIAHSVAEAEAALR--EIFTQTGA 215
Query: 181 KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
+ +IE+ G E + +DG+ P QD+ YEGD GP+TGGMG I PF
Sbjct: 216 QAVIEDFMTGQEVSILALTDGKRYALTPPSQDHKTIYEGDTGPMTGGMGV------ICPF 269
Query: 241 ITKEDWKMALRT--LEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAIN 298
E+ +R +E+T+ MR EG P++G+LY ML+ +GP ++E+NARFGDPEA
Sbjct: 270 PVGEEQLNIIRRDIVEKTLAGMRAEGIPFRGVLYAGLMLTPQGPKVVEFNARFGDPEAEA 329
Query: 299 VLSILEDNLVEIAEGIVKGRVRGA--KFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAI 356
VL +LE +L + A +G++ A +F++ A+ V LA GYP P +G + + ++
Sbjct: 330 VLPLLESDLAQHALDAARGQLDPAQVRFRDGASAVVILAAPGYPAEPRKGIVLDIPADSP 389
Query: 357 KEEGAKIVYASVDENMKLL---GSRALAMVGVADTLEEA 392
+ AK+ +A E L G R LA+ G+ ++ E+A
Sbjct: 390 E---AKVFHAGTTERDGQLVSSGGRVLAVTGLGESREDA 425
>sp|P12039|PUR2_BACSU PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|68645|pir||AJBSAG
phosphoribosylamine--glycine ligase (EC 6.3.4.13)
[validated] - Bacillus subtilis
>gi|143374|gb|AAA22684.1| (J02732) phosphoribosyl
glycinamide synthetase (PUR-D; gtg start codon)
[Bacillus subtilis] >gi|2465561|gb|AAB72186.1|
(AF011544) phosphoribosylglycinamide synthetase; GAR
synthetase [Bacillus subtilis]
>gi|2632967|emb|CAB12473.1| (Z99107)
phosphoribosylglycinamide synthetase [Bacillus subtilis]
Length = 422
Score = 224 bits (564), Expect = 2e-57
Identities = 144/434 (33%), Positives = 228/434 (52%), Gaps = 37/434 (8%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M VL++G GGREH + A+ V + N G+A ++ I +E+D +V FA+
Sbjct: 1 MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLVNI-EESDHAGLVSFAK 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
V L +GPE PL G+V+ E+ G+ GP+K AA +E +K +A++ M++ DIP +
Sbjct: 60 QNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGSKQFAKDLMKKYDIPTAE 119
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQ------LKDNEEAKEYAEY 174
++ F +E KA++ E G P+V+K GL GKGV V + L D E +++ +
Sbjct: 120 -YETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEEEAIACLHDFLEDEKFGD- 177
Query: 175 LIKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
V+IEE G EF+ F G V PM + QD+ A++GD GP TGGMG+YS
Sbjct: 178 ---ASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFDGDKGPNTGGMGAYSP- 233
Query: 235 NHILPFITKEDWKMALRTL-EETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
+P I++E + A+ T+ + KAM +EG + G+LY ML+ G +IE+NARFGD
Sbjct: 234 ---VPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTENGSKVIEFNARFGD 290
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGA------ 347
PE VL +E +LV++ ++ + ++++ A V LA +GYPE+ +G
Sbjct: 291 PETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASEGYPESYAKGTPIGSLA 350
Query: 348 ----EIMVNEEAIKEEGAKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHV 403
+++V K EG + V G R + +T E A + +
Sbjct: 351 AETEQVVVFHAGTKAEGGEFV---------TNGGRVANVTAFDETFEAARDRVYKAVDEI 401
Query: 404 RGP-VFYRKDVGTK 416
P +F+RKD+G +
Sbjct: 402 FKPGLFFRKDIGAR 415
>pir||B82344 phosphoribosylamine--glycine ligase VC0275 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9654685|gb|AAF93450.1| (AE004115)
phosphoribosylamine--glycine ligase [Vibrio cholerae]
Length = 429
Score = 223 bits (562), Expect = 3e-57
Identities = 145/428 (33%), Positives = 235/428 (54%), Gaps = 23/428 (5%)
Query: 1 MRVLLVGGGGREHAIGEALARGGA--ELYVVSKHKNPGLARISRDYGISKETDVEKVVRF 58
M+VL++G GGREHA+ +A+ +YV + L ++ I TD+ +V F
Sbjct: 1 MQVLIIGSGGREHALAWKVAQNPQVDTIYVAPGNAGTALEHKVQNVNIGI-TDIPALVAF 59
Query: 59 ARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPG 118
A+ ++L +GPEAPL G+V+A G+P GPT+ AA+LE +KA+ ++F+ R++IP
Sbjct: 60 AQDKAIELTIVGPEAPLVIGVVDAFRAAGLPIFGPTQGAAQLEGSKAFTKDFLARHNIP- 118
Query: 119 RKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE---YAEYL 175
+ F ++E A++ E G P+VVK GL GKGV +V L++ E+A +
Sbjct: 119 TAAYANFTEIEPALAYVREKGAPIVVKADGLAAGKGV-IVAMTLQEAEDAIQDMLAGNAF 177
Query: 176 IKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSN 235
+V++EE DG E +F V DG NV+PM QD+ + D GP TGGMG+YS +
Sbjct: 178 GSAGSRVVVEEFLDGEEASFIVMVDGENVLPMATSQDHKRVGDADTGPNTGGMGAYSPA- 236
Query: 236 HILPFITKEDWKMALR-TLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGD 293
P +T++ +R ++ T++ M EG Y G LY M+ G P +IEYN RFGD
Sbjct: 237 ---PVVTQDVHDRVMREVIDPTVRGMAAEGNTYTGFLYAGLMIDSTGAPKVIEYNCRFGD 293
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVR--GAKFQEKATVVKYLAPKGYPENPIRGAEIMV 351
PE ++ L+ +LVE+ + + G++ +K+ +A++ LA GYP + +G E++
Sbjct: 294 PETQPIMMRLQSDLVELCQAAIAGKLDQVESKWDPRASIGVVLAAGGYPGDYAKG-EVIS 352
Query: 352 NEEAIKEEGAKIVYASVD---ENMKLLGSRALAMVGVADTLEEAEKIAE--AGIRHVRGP 406
+ G K+ +A + + + G R L + +T+ EA++ A A H G
Sbjct: 353 GLPTQESAGQKVFHAGTETQGDQVVTNGGRVLCATALGNTVLEAQQRAYQLADQIHWNG- 411
Query: 407 VFYRKDVG 414
+F R+D+G
Sbjct: 412 MFCRRDIG 419
>gi|4503915 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase;
phosphoribosylglycinamide formyltransferase [Homo
sapiens] >gi|11526207|ref|XP_009737.1|
phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase [Homo sapiens]
>gi|131616|sp|P22102|PUR2_HUMAN TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68647|pir||AJHUPR
purine synthesis multifunctional protein - human
>gi|31642|emb|CAA38119.1| (X54199) glycinamide
ribonucleotide synthetase-aminoimidazole ribonucleotide
synthetase-glycinamide ribonucleotide transformylase
[Homo sapiens]
Length = 1010
Score = 220 bits (556), Expect = 2e-56
Identities = 156/451 (34%), Positives = 238/451 (52%), Gaps = 35/451 (7%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKE-TDVEKVVRFAR 60
RVL++G GGREH + LA+ V+ N G A + + +D + +F +
Sbjct: 4 RVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQFCK 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
++ +GPEAPL AGIV L G+ GPT EAA+LE++K +A+EFM+R+ IP +
Sbjct: 64 EKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQ 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
+K F EE ++I P +VVK GL GKGV V K EEA + + ++++
Sbjct: 124 -WKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVA----KSKEEACKAVQEIMQEK 178
Query: 180 G------KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY-- 231
++IEE DG E + F+DG+ V PMP QD+ EGD GP TGGMG+Y
Sbjct: 179 AFGAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCP 238
Query: 232 --SCSNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNA 289
SN +L K+ L+ T+ M++EG PY GILY ML++ GP ++E+N
Sbjct: 239 APQVSNDLL-------LKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNC 291
Query: 290 RFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRG 346
RFGDPE +L +L+ +L E+ + + G + + + + +A KGYP + +G
Sbjct: 292 RFGDPECQVILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKG 351
Query: 347 AEIMVNEEAIKEEGAKIVYASVD-ENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHV 403
EI EA + G ++ +A +N K++ G R LA+ + + L A + A+ G+ +
Sbjct: 352 VEITGFPEA-QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAI 410
Query: 404 R-GPVFYRKDVGTKESI---EKRIRTMKELG 430
+ YRKDVG + + R T KE G
Sbjct: 411 KFEGAIYRKDVGFRAIAFLQQPRSLTYKESG 441
>dbj|BAA06809.1| (D32051) GARS protein [Homo sapiens]
Length = 433
Score = 219 bits (552), Expect = 5e-56
Identities = 150/432 (34%), Positives = 231/432 (52%), Gaps = 32/432 (7%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKE-TDVEKVVRFAR 60
RVL++G GGREH + LA+ V+ N G A + + +D + +F +
Sbjct: 4 RVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQFCK 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
++ +GPEAPL AGIV L G+ GPT EAA+LE++K +A+EFM+R+ IP +
Sbjct: 64 EKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQ 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
+K F EE ++I P +VVK GL GKGV V K EEA + + ++++
Sbjct: 124 -WKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVA----KSKEEACKAVQEIMQEK 178
Query: 180 G------KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY-- 231
++IEE DG E + F+DG+ V PMP QD+ EGD GP TGGMG+Y
Sbjct: 179 AFGAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCP 238
Query: 232 --SCSNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNA 289
SN +L K+ L+ T+ M++EG PY GILY ML++ GP ++E+N
Sbjct: 239 APQVSNDLL-------LKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNC 291
Query: 290 RFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRG 346
RFGDPE +L +L+ +L E+ + + G + + + + +A KGYP + +G
Sbjct: 292 RFGDPECQVILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKG 351
Query: 347 AEIMVNEEAIKEEGAKIVYASVD-ENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHV 403
EI EA + G ++ +A +N K++ G R LA+ + + L A + A+ G+ +
Sbjct: 352 VEITGFPEA-QALGLEVSHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAI 410
Query: 404 R-GPVFYRKDVG 414
+ YRKD+G
Sbjct: 411 KFEGAIYRKDIG 422
>pir||S37104 phosphoribosylamine--glycine ligase (EC 6.3.4.13) - Arabidopsis
thaliana (fragment)
Length = 422
Score = 217 bits (548), Expect = 2e-55
Identities = 143/425 (33%), Positives = 222/425 (51%), Gaps = 29/425 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEK---VVR 57
+ VL++GGGGREHA+ AL R + V+ N G++ S D + D+ V+
Sbjct: 4 VNVLVIGGGGREHALCHALKRSPSCDSVLCAPGNAGISS-SGDATCVPDLDISDSLAVIS 62
Query: 58 FARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIP 117
F + WNV L +GPE PL AG+ N L + GI T GP+ +AA LE +K + + + +IP
Sbjct: 63 FCQKWNVGLVVVGPEVPLVAGLANDLVKAGILTFGPSSQAAALEGSKNFMKNLCHKYNIP 122
Query: 118 GRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIK 177
K +K F D K +I E G P+V+K GL GKGV V + EEA E + ++
Sbjct: 123 TAK-YKTFSDASAAKEYIQEQGAPIVIKADGLAAGKGVTVA----MELEEAFEAVDSMLV 177
Query: 178 K------DGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY 231
K +V++EE +G E +F DG N IP+ QD+ +GD GP TGGMG+Y
Sbjct: 178 KGVFGSAGCQVVVEEFLEGEEASFFALVDGENAIPLESAQDHKRVGDGDTGPNTGGMGAY 237
Query: 232 SCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREGPVI--IEYN 288
S + P +TKE + + + T+K M +EG + G+L+ M+ ++ + IE+N
Sbjct: 238 SPA----PVLTKELQDFVMESIIHPTVKGMAEEGCKFVGVLFAGLMIEKKSGFLSFIEFN 293
Query: 289 ARFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAK--FQEKATVVKYLAPKGYPENPIRG 346
RFGDPE ++ LE +L ++ KG + G + + + +V +A GYP + +G
Sbjct: 294 VRFGDPECQVLMMRLESDLAKVLLAACKGELSGVSLDWSKDSAMVVVMASNGYPGSYEKG 353
Query: 347 AEIMVNEEAIK-EEGAKIVYASV----DENMKLLGSRALAMVGVADTLEEAEKIAEAGIR 401
+ I EEA + G K+ +A + N+ G R L + LEEA + A + ++
Sbjct: 354 SIIKNLEEAERVAPGVKVFHAGTGLDSEGNVVATGGRVLGVTAKGKDLEEARERAYSAVQ 413
Query: 402 HVRGP 406
+ P
Sbjct: 414 QINWP 418
>sp|P52420|PUR2_ARATH PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PRECURSOR (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE)
Length = 529
Score = 217 bits (548), Expect = 2e-55
Identities = 143/425 (33%), Positives = 222/425 (51%), Gaps = 29/425 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEK---VVR 57
+ VL++GGGGREHA+ AL R + V+ N G++ S D + D+ V+
Sbjct: 111 VNVLVIGGGGREHALCHALKRSPSCDSVLCAPGNAGISS-SGDATCVPDLDISDSLAVIS 169
Query: 58 FARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIP 117
F + WNV L +GPE PL AG+ N L + GI T GP+ +AA LE +K + + + +IP
Sbjct: 170 FCQKWNVGLVVVGPEVPLVAGLANDLVKAGILTFGPSSQAAALEGSKNFMKNLCHKYNIP 229
Query: 118 GRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIK 177
K +K F D K +I E G P+V+K GL GKGV V + EEA E + ++
Sbjct: 230 TAK-YKTFSDASAAKEYIQEQGAPIVIKADGLAAGKGVTVA----MELEEAFEAVDSMLV 284
Query: 178 K------DGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY 231
K +V++EE +G E +F DG N IP+ QD+ +GD GP TGGMG+Y
Sbjct: 285 KGVFGSAGCQVVVEEFLEGEEASFFALVDGENAIPLESAQDHKRVGDGDTGPNTGGMGAY 344
Query: 232 SCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREGPVI--IEYN 288
S + P +TKE + + + T+K M +EG + G+L+ M+ ++ + IE+N
Sbjct: 345 SPA----PVLTKELQDFVMESIIHPTVKGMAEEGCKFVGVLFAGLMIEKKSGFLSFIEFN 400
Query: 289 ARFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAK--FQEKATVVKYLAPKGYPENPIRG 346
RFGDPE ++ LE +L ++ KG + G + + + +V +A GYP + +G
Sbjct: 401 VRFGDPECQVLMMRLESDLAKVLLAACKGELSGVSLDWSKDSAMVVVMASNGYPGSYEKG 460
Query: 347 AEIMVNEEAIK-EEGAKIVYASV----DENMKLLGSRALAMVGVADTLEEAEKIAEAGIR 401
+ I EEA + G K+ +A + N+ G R L + LEEA + A + ++
Sbjct: 461 SIIKNLEEAERVAPGVKVFHAGTGLDSEGNVVATGGRVLGVTAKGKDLEEARERAYSAVQ 520
Query: 402 HVRGP 406
+ P
Sbjct: 521 QINWP 525
>sp|P21872|PUR2_CHICK TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68648|pir||AJCHPR
purine synthesis multifunctional protein - chicken
>gi|62899|emb|CAA38120.1| (X54200) glycinamide
ribonucleotide synthetase-aminoimidazole ribonucleotide
synthetase-glycinamide ribonucleotide transformylase
[Gallus gallus]
Length = 1003
Score = 216 bits (545), Expect = 3e-55
Identities = 143/431 (33%), Positives = 231/431 (53%), Gaps = 30/431 (6%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISR-DYGISKETDVEKVVRFAR 60
RVL++G GGREHA+ LA+ V N G A + ++ + +F R
Sbjct: 4 RVLVIGSGGREHALAWKLAQSPHVKQVFVAPGNAGTANSGKISNSAVSVSNHAALAQFCR 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
+ L +GPE PL AGIV+ L G+ GPT AA+LE++K++ + F++R+ IP +
Sbjct: 64 DQEIRLVVVGPEVPLAAGIVDDLTAAGVRCFGPTARAAQLESSKSFTKSFLDRHGIPTAR 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
+K F D + ++I+ P +VVK GL GKGV V + EEA + +++
Sbjct: 124 -WKSFTDPKAACSFINSANFPALVVKASGLAAGKGVIVAS----NKEEACKAVNDIMQDK 178
Query: 180 G------KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSC 233
V++EE +G E + F+DG + PMP QD+ +GD GP TGGMG+YS
Sbjct: 179 TFGTAGETVVVEELLEGEEVSCLCFTDGVTIAPMPPAQDHKRLKDGDEGPNTGGMGAYSP 238
Query: 234 SNHILPFITKEDWKMALR--TLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARF 291
+ I +D + +R L++T+ MRKEG PY G+LY ML+++GP ++E+N RF
Sbjct: 239 APQI-----SKDLLLKIRETVLQKTLDGMRKEGIPYLGVLYAGLMLTKDGPKVLEFNCRF 293
Query: 292 GDPEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRGAE 348
GDPE +L +L+ +L E+ + ++ ++ + +++ A V +A +GYP +G E
Sbjct: 294 GDPECQVILPLLKSDLYEVMQAVINKKLSSSMPIWYEDSAAVTVVMASEGYPGTYPKGLE 353
Query: 349 IMVNEEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHV-- 403
I +A KE G ++ +A D + G R L + + + L A + A G+ +
Sbjct: 354 ITGLSKA-KELGLEVFHAGTALKDGKVVTNGGRVLTVTAIKEDLMTALQEANKGVAAINF 412
Query: 404 RGPVFYRKDVG 414
+G + YRKD+G
Sbjct: 413 KGSI-YRKDIG 422
>sp|P20772|PUR2_SCHPO BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADE1 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORIBOSYL-AM>
>gi|82792|pir||S00652 ADE1 multifunctional protein -
fission yeast (Schizosaccharomyces pombe)
>gi|4904|emb|CAA29820.1| (X06601) GARSase/AIRSase (AA 1
- 788) [Schizosaccharomyces pombe]
>gi|2832882|emb|CAA16823.1| (AL021730) bifunctional
purine biosynthetic protein
ade1-includes:phosphoribosylamine--glycine ligase
[Schizosaccharomyces pombe]
Length = 788
Score = 215 bits (543), Expect = 6e-55
Identities = 150/426 (35%), Positives = 219/426 (51%), Gaps = 26/426 (6%)
Query: 4 LLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET----DVEKVVRFA 59
LL+G GGREH I L V N G A + + D E++V+FA
Sbjct: 7 LLIGNGGREHTIAWKLCESPLISKVYVAPGNGGTASNGAESKMENVNIGVCDFEQLVKFA 66
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
+V+L GPE PL GI R GIP GP+ AAR+E +K ++++FM RN+IP
Sbjct: 67 LDKDVNLVIPGPELPLVEGIEGHFRRVGIPCFGPSALAARMEGSKVFSKDFMHRNNIP-T 125
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
++K F + + K+++D VV+K GL GKGV + K +EA E E ++ +
Sbjct: 126 AVYKSFSNYDHAKSFLDTCTFDVVIKADGLAAGKGVIIP----KTKKEAFEALESIMLNE 181
Query: 180 -----GK-VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSC 233
GK V+IEE +G E + FSDG +P QD+ A++GD GP TGGMG Y+
Sbjct: 182 EFGSAGKNVVIEELLEGEELSILTFSDGYTCRSLPPAQDHKRAFDGDKGPNTGGMGCYAP 241
Query: 234 SNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
+ P + + + ++ TI MR EGYP GIL+ ML+ GP ++EYN RFGD
Sbjct: 242 TPVASPKLLET---VQSTIIQPTIDGMRHEGYPLVGILFTGLMLTPSGPRVLEYNVRFGD 298
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAK--FQEKATVVKYLAPKGYPENPIRGAEIMV 351
PE VL +LE +L EI V R+ K + GYP P +I +
Sbjct: 299 PETQAVLPLLESDLAEIILACVNHRLDAIDIVISRKFSCAVVCVAGGYP-GPYNKGDI-I 356
Query: 352 NEEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+A+K++ +I +A D N+ G R LA+ D++E A ++A G++ V +
Sbjct: 357 TFDALKDKNTRIFHAGTSIRDGNVVTNGGRVLAVEATGDSVEAAVRLAYEGVKTVHFDKM 416
Query: 408 FYRKDV 413
FYRKD+
Sbjct: 417 FYRKDI 422
>gb|AAF71749.1| (AF257743) phosphoribosylglycinamide formyltransferase; Gart [Danio
rerio]
Length = 1017
Score = 213 bits (537), Expect = 3e-54
Identities = 143/429 (33%), Positives = 229/429 (53%), Gaps = 25/429 (5%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVV-RFAR 60
RVL++G GGREHA+ A+ V+ N G A + + ++ ++ +
Sbjct: 4 RVLVIGSGGREHALAWKFAQSPHVQQVLVAPGNAGTANCGKISNSEVSVNNHSILAQYCK 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
V L +GPE PL AG+V+ L G+ GP+ AA+LE +K++++ FM+R++IP +
Sbjct: 64 DHKVGLVVVGPEVPLAAGMVDDLTAAGVLCFGPSARAAQLEASKSFSKAFMDRHNIPTAR 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
+ F D ++ A+I + P +VVK GL GKGV V +D +EA + ++K
Sbjct: 124 -WSSFTDPQQACAYIRDADFPALVVKASGLAAGKGVIVA----QDKDEACQAVLDIMKDK 178
Query: 180 G------KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSC 233
V++EE DG E + FSDG V PMP QD+ +GD+GP TGGMG+Y
Sbjct: 179 AFGSAGETVVVEELLDGQEVSCLCFSDGVTVAPMPPAQDHKRLLDGDMGPNTGGMGAYCP 238
Query: 234 SNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
+ + + +E ++ L++T+ MR+EG PY G+LY ML+ +GP ++E+N RFGD
Sbjct: 239 TPQVSDELLQE---ISRSVLQKTVDGMREEGAPYVGVLYAGLMLTAQGPRVLEFNCRFGD 295
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRGAEIM 350
PE +L +L+ +L E+ ++ + A Q+ A V +A GYP +G EI
Sbjct: 296 PECQVLLPLLQSDLYEVCMQTLRCELDSASVQWLQDCAAVTVVMASGGYPNAYRKGLEIS 355
Query: 351 VNEEAIKEEGAKIVYA--SVDENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHVRGP 406
+A E G ++ +A ++ E ++ G R L + V TLE A + A G+ + P
Sbjct: 356 GLSQA-SEMGVQVFHAGTALKEGGGVITSGGRVLTVTAVRPTLESALQSANEGVGAISFP 414
Query: 407 -VFYRKDVG 414
YR+D+G
Sbjct: 415 DAVYRRDIG 423
>gb|AAC96120.1| (AF083221) glycinamide ribonucleotide transformylase [Takifugu
rubripes]
Length = 1008
Score = 213 bits (536), Expect = 4e-54
Identities = 142/430 (33%), Positives = 229/430 (53%), Gaps = 26/430 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVV-RFA 59
++VL+VGGGGREHA+ LA+ V+ N G A + ++ ++
Sbjct: 3 VKVLVVGGGGREHALAWKLAQSPHIQQVLVAPGNAGTANGEKISNSEVSVSNHSILAQYC 62
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
+ V L +GPEAPL AGIV+ L G+ GP+ +AA+LE +K++++ FMER+ IP
Sbjct: 63 KDHQVGLVIVGPEAPLAAGIVDDLTAAGVACFGPSSKAAQLEASKSYSKAFMERHGIPTA 122
Query: 120 KLFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKK 178
+ + F D E +I P +VVK GL GKGV V D +EA + A I K
Sbjct: 123 R-YGSFTDPREACNFIRTADFPALVVKASGLAAGKGVIVAA----DQDEACQ-AVMDIMK 176
Query: 179 DGK-------VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY 231
DG V++EE +G E + F+DG +V PMP QD+ +GD+GP TGGMG+Y
Sbjct: 177 DGAFGSAGDTVVVEELLEGEEVSCLCFTDGSSVAPMPPAQDHKRLQDGDLGPNTGGMGAY 236
Query: 232 SCSNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARF 291
+ + + ++ ++ L ++T+ MR+EG PY G+LY ML+++GP ++E+N RF
Sbjct: 237 CPTPQVSQELLQQIREIVL---QKTVDGMREEGSPYVGVLYAGLMLTKQGPKVLEFNCRF 293
Query: 292 GDPEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRGAE 348
GDPE +L +L+ +L E+ + ++G++ + + + V +A GYP +G +
Sbjct: 294 GDPECQVLLPLLKSDLYEVIQNTLEGKLATSAPVWHNDSSAVTVVMASSGYPGTYAKGVQ 353
Query: 349 IMVNEEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRG 405
I +++ ++ +A D + G R L + V LE A + A G+ +
Sbjct: 354 IK-GLSQLQDMELQVFHAGTALKDGCVVSSGGRVLTVTAVRPALETALQAANQGVAAIGF 412
Query: 406 P-VFYRKDVG 414
P YR+D+G
Sbjct: 413 PGAVYRRDIG 422
>pir||F83038 phosphoribosylamine--glycine ligase PA4855 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951127|gb|AAG08240.1|AE004899_1 (AE004899)
phosphoribosylamine--glycine ligase [Pseudomonas
aeruginosa]
Length = 429
Score = 213 bits (536), Expect = 4e-54
Identities = 149/434 (34%), Positives = 225/434 (51%), Gaps = 20/434 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET-DVEKVVRFA 59
M VL++G GGREHA+ +A+ V N G A ++ ++ + +E++ FA
Sbjct: 1 MNVLIIGSGGREHALAWKVAQDPRVAKVFVAPGNAGTATEAKCENVAIDVLALEQLADFA 60
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
NV L +GPEAPL AG+V+ G+ GPT AA+LE +KA+ ++F+ R+ IP
Sbjct: 61 AK-NVQLTIVGPEAPLVAGVVDLFRERGLDIFGPTAGAAQLEGSKAFTKDFLARHRIP-T 118
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE---YAEYLI 176
++ F +VE A++ E G P+V+K GL GKGV +V L + E A
Sbjct: 119 AAYRNFTEVEPALAYLHEQGAPIVIKADGLAAGKGV-IVAMNLDEAEAAVRDMLAGNAFG 177
Query: 177 KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
+V+IEE DG E +F V DG+NV+PM QD+ +GD GP TGGMG+YS +
Sbjct: 178 DAGSRVVIEEFLDGEEASFIVMVDGQNVLPMATSQDHKRVGDGDSGPNTGGMGAYSPA-- 235
Query: 237 ILPFITKEDWKMAL-RTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
P +T E + L + T++ M +EG Y G LY M+ + G P +IE+N RFGDP
Sbjct: 236 --PVVTAEVHQRVLDEVIYPTVRGMAEEGNVYTGFLYAGLMIDKSGAPKVIEFNCRFGDP 293
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVR--GAKFQEKATVVKYLAPKGYPENPIRGAEIMVN 352
E ++ LE +LV + E + + A + + TV LA GYP + +G I
Sbjct: 294 ETQPIMVRLESSLVLLVEAALAKALDKVEATWDPRPTVGVVLAAGGYPGDYAKGEVIEGL 353
Query: 353 EEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPVF 408
EA +G K+ +A D + G R L + +++ A++ A +R F
Sbjct: 354 AEAAALDG-KVFHAGTALKDGQVVTSGGRVLCATAIGESVSAAQQQAYRLAEKIRWNGCF 412
Query: 409 YRKDVGTKESIEKR 422
YRKD+G + +R
Sbjct: 413 YRKDIGYRAIARER 426
>sp|P26977|PUR2_SALTY PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|96826|pir||S18489
phosphoribosylamine--glycine ligase (EC 6.3.4.13) -
Salmonella typhimurium >gi|154288|gb|AAA27198.1|
(M66160) 5-phosphoribosylglycinamide synthetase
[Salmonella typhimurium] >gi|6960361|gb|AAF33521.1|
(AF170176) Salmonella typhimurium
phosphoribosylamine--glycine ligase (SW:P26977);
contains similarity to Pfam domain PF01071 (GARS),
Score=962, E=1.5e-285, N=1 [Salmonella typhimurium LT2]
Length = 429
Score = 212 bits (535), Expect = 5e-54
Identities = 144/430 (33%), Positives = 232/430 (53%), Gaps = 26/430 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGA--ELYVVSKHKNPGLARISRDYGISKETDVEKVVRF 58
M+VL++G GGREHA+ A+ ++V + L ++ I TD+ ++ F
Sbjct: 1 MKVLVIGNGGREHALAWKAAQSPLVDTVFVAPGNAGTALEPALQNVAIGV-TDIPALLSF 59
Query: 59 ARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPG 118
A+ +DL +GPEAPL G+V+A G+ GPT+ AA+LE +KA+ ++F+ R+ IP
Sbjct: 60 AQHEKIDLTIVGPEAPLVIGVVDAFRAAGLKIFGPTEGAAQLEGSKAFTKDFLARHQIPT 119
Query: 119 RKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE--YAEYLI 176
+ ++ F ++E A++ E G P+V+K GL GKGV +V L++ E A A
Sbjct: 120 AE-YQNFTEIEPALAYLREKGAPIVIKADGLAAGKGV-IVAMTLEEAEAAVHDMLAGNAF 177
Query: 177 KKDG-KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSN 235
G +++IEE DG E +F V DG +V+PM QD+ GD GP TGGMG+YS +
Sbjct: 178 GDAGHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGNGDTGPNTGGMGAYSPA- 236
Query: 236 HILPFITKEDWKMAL-RTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGD 293
P +T E + + R + T+K M EG Y G LY M+ ++G P +IE+N RFGD
Sbjct: 237 ---PVVTDEVHQRTMERIIWPTVKGMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCRFGD 293
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRV--RGAKFQEKATVVKYLAPKGYPENPIRGAEI-- 349
PE ++ ++ +LV++ G++ + +++ E+A++ +A GYP + G EI
Sbjct: 294 PETQPIMLRMKSDLVDLCLAACDGKLDEKTSEWDERASLGVVIAAGGYPGSYSTGDEIHG 353
Query: 350 ----MVNEEAIKEEGAKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR- 404
V + + G K+ + D+ + G R L + T+ EA+K A A + +R
Sbjct: 354 LPLEEVADGKVFHAGTKL---ADDDRVLTSGGRVLCATALGHTVAEAQKRAYALMTDIRW 410
Query: 405 GPVFYRKDVG 414
F R D+G
Sbjct: 411 DGSFSRNDIG 420
>pir||T46882 phosphoribosylamine--glycine ligase (EC 6.3.4.13) [imported] -
mouse >gi|403491|gb|AAA19012.1| (U01023) glycinamide
ribonucleotide sythetase [Mus musculus]
Length = 433
Score = 211 bits (532), Expect = 1e-53
Identities = 143/428 (33%), Positives = 225/428 (52%), Gaps = 24/428 (5%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET-DVEKVVRFAR 60
RVL++G GGREH + LA+ V+ N G A + + D + +F +
Sbjct: 4 RVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTAGAGKISNAAVSVNDHSALAQFCK 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
++L +GPEAPL AGIV L G+ GPT +AA+LE++K +A+EFM+R++IP +
Sbjct: 64 DEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIPTAQ 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
++ F + E+ ++I P +VVK GL GKGV V Q E + E + +K
Sbjct: 124 -WRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQA---EACRAVQEIMQEKS 179
Query: 180 -----GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
V++EE +G E + F+DG+ V MP QD+ +GD GP TGGMG+Y +
Sbjct: 180 FGAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPA 239
Query: 235 NHILPFITKEDW-KMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
P ++K+ K+ L+ + M++EG PY GILY ML+++GP ++E+N RFGD
Sbjct: 240 ----PQVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGD 295
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRGAEIM 350
PE +L +L+ +L E+ + + G + + + + V +A KGYP +G EI
Sbjct: 296 PECQVILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEIT 355
Query: 351 VNEEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GP 406
EA + G ++ +A D + G R L + V + L A A G+ ++
Sbjct: 356 GFPEA-QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEG 414
Query: 407 VFYRKDVG 414
YRKD+G
Sbjct: 415 AIYRKDIG 422
>pir||I67805 purine synthesis multifunctional protein - mouse
>gi|403493|gb|AAA19013.1| (U01024) glycinamide
ribonucleotide sythetase (GARS), aminoimidazole
ribonucleotide synthetase (AIRS), glycinamide
ribonucleotide formyltransferase (GART) [Mus musculus]
Length = 1010
Score = 211 bits (532), Expect = 1e-53
Identities = 143/428 (33%), Positives = 225/428 (52%), Gaps = 24/428 (5%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET-DVEKVVRFAR 60
RVL++G GGREH + LA+ V+ N G A + + D + +F +
Sbjct: 4 RVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTAGAGKISNAAVSVNDHSALAQFCK 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
++L +GPEAPL AGIV L G+ GPT +AA+LE++K +A+EFM+R++IP +
Sbjct: 64 DEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIPTAQ 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
++ F + E+ ++I P +VVK GL GKGV V Q E + E + +K
Sbjct: 124 -WRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQA---EACRAVQEIMQEKS 179
Query: 180 -----GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
V++EE +G E + F+DG+ V MP QD+ +GD GP TGGMG+Y +
Sbjct: 180 FGAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPA 239
Query: 235 NHILPFITKEDW-KMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
P ++K+ K+ L+ + M++EG PY GILY ML+++GP ++E+N RFGD
Sbjct: 240 ----PQVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGD 295
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRGAEIM 350
PE +L +L+ +L E+ + + G + + + + V +A KGYP +G EI
Sbjct: 296 PECQVILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEIT 355
Query: 351 VNEEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GP 406
EA + G ++ +A D + G R L + V + L A A G+ ++
Sbjct: 356 GFPEA-QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEG 414
Query: 407 VFYRKDVG 414
YRKD+G
Sbjct: 415 AIYRKDIG 422
>gb|AAC53250.1| (U20892) glycinamide ribonucleotide synthetase [Mus musculus]
Length = 433
Score = 211 bits (531), Expect = 2e-53
Identities = 143/428 (33%), Positives = 225/428 (52%), Gaps = 24/428 (5%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET-DVEKVVRFAR 60
RVL++G GGREH + LA+ V+ N G A + + D + +F +
Sbjct: 4 RVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTAGAGKISNAAVSVNDHSALAQFCK 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
++L +GPEAPL AGIV L G+ GPT +AA+LE++K +A+EFM+R++IP +
Sbjct: 64 DEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIPTAQ 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
++ F + E+ ++I P +VVK GL GKGV V Q E + E + +K
Sbjct: 124 -WRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQA---EACRAVQEIMQEKS 179
Query: 180 -----GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
V++EE +G E + F+DG+ V MP QD+ +GD GP TGGMG+Y +
Sbjct: 180 FGAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPA 239
Query: 235 NHILPFITKEDW-KMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
P ++K+ K+ L+ + M++EG PY GILY ML+++GP ++E+N RFGD
Sbjct: 240 ----PQVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGD 295
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRGAEIM 350
PE +L +L+ +L E+ + + G + + + + V +A KGYP +G EI
Sbjct: 296 PECQVILPLLKSDLYEVMQSTLGGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEIT 355
Query: 351 VNEEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GP 406
EA + G ++ +A D + G R L + V + L A A G+ ++
Sbjct: 356 GFPEA-QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEG 414
Query: 407 VFYRKDVG 414
YRKD+G
Sbjct: 415 AIYRKDIG 422
>gi|6857793 phosphoribosylglycinamide formyltransferase [Mus musculus]
>gi|2500003|sp|Q64737|PUR2_MOUSE TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI>
>gi|691792|gb|AAC53251.1| (U20892) glycinamide
ribonucleotide synthetase-aminoimidazole ribonucleotide
synthetase-glycinamide ribonucleotide formyltransferase
[Mus musculus]
Length = 1010
Score = 211 bits (531), Expect = 2e-53
Identities = 143/428 (33%), Positives = 225/428 (52%), Gaps = 24/428 (5%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET-DVEKVVRFAR 60
RVL++G GGREH + LA+ V+ N G A + + D + +F +
Sbjct: 4 RVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTAGAGKISNAAVSVNDHSALAQFCK 63
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
++L +GPEAPL AGIV L G+ GPT +AA+LE++K +A+EFM+R++IP +
Sbjct: 64 DEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIPTAQ 123
Query: 121 LFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
++ F + E+ ++I P +VVK GL GKGV V Q E + E + +K
Sbjct: 124 -WRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQA---EACRAVQEIMQEKS 179
Query: 180 -----GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
V++EE +G E + F+DG+ V MP QD+ +GD GP TGGMG+Y +
Sbjct: 180 FGAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPA 239
Query: 235 NHILPFITKEDW-KMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGD 293
P ++K+ K+ L+ + M++EG PY GILY ML+++GP ++E+N RFGD
Sbjct: 240 ----PQVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGD 295
Query: 294 PEAINVLSILEDNLVEIAEGIVKGRVRGAK---FQEKATVVKYLAPKGYPENPIRGAEIM 350
PE +L +L+ +L E+ + + G + + + + V +A KGYP +G EI
Sbjct: 296 PECQVILPLLKSDLYEVMQSTLGGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEIT 355
Query: 351 VNEEAIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GP 406
EA + G ++ +A D + G R L + V + L A A G+ ++
Sbjct: 356 GFPEA-QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEG 414
Query: 407 VFYRKDVG 414
YRKD+G
Sbjct: 415 AIYRKDIG 422
>sp|P43845|PUR2_HAEIN PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|1075149|pir||C64100
phosphoribosylamine--glycine ligase (EC 6.3.4.13) -
Haemophilus influenzae (strain Rd KW20)
>gi|1573905|gb|AAC22545.1| (U32770)
phosphoribosylamine--glycine ligase (purD) [Haemophilus
influenzae Rd]
Length = 429
Score = 210 bits (530), Expect = 2e-53
Identities = 147/437 (33%), Positives = 236/437 (53%), Gaps = 22/437 (5%)
Query: 1 MRVLLVGGGGREHAIGEALARG--GAELYVVSKHKNPGLARISRDYGISKETDVEKVVRF 58
M +L++G GGREHA+ +A+ +++V + L + IS TD+ +V+F
Sbjct: 1 MNILIIGNGGREHALAWKVAQSPLADKVFVAPGNAGTALEHKVENVNISA-TDIPALVKF 59
Query: 59 ARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPG 118
A+ + L +GPEAPL G+V+A G+ GP K AA+LE +KA+ ++F+ R+ IP
Sbjct: 60 AQDKQIGLTIVGPEAPLVIGVVDAFREAGLKIFGPAKAAAQLEGSKAFTKDFLARHKIPT 119
Query: 119 RKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE---YAEYL 175
+ ++ F +VE ++ E G P+VVK GL GKGV +V L++ E+A
Sbjct: 120 AE-YQNFTEVEPALTYLREKGTPIVVKADGLAAGKGV-IVAMTLQEAEDAVRDMLSGNAF 177
Query: 176 IKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSN 235
+ +V+IEE DG E +F V DG+NV PM QD+ E D G TGGMG+YS +
Sbjct: 178 GEAGSRVVIEEFLDGEEASFIVMVDGKNVEPMASSQDHKRVGENDTGLNTGGMGAYSPAP 237
Query: 236 HILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
I P I K + T+ M EG Y G LY M+ G P +IE+N RFGDP
Sbjct: 238 VITPEIHSRIMK---EVIYPTVNGMAAEGNVYTGFLYAGLMIMPNGQPKVIEFNCRFGDP 294
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVRG--AKFQEKATVVKYLAPKGYPENPIRGAEIM-V 351
E ++ L+ +LVE+ G++ +++ +A++ LA +GYP++ +G EI +
Sbjct: 295 ETQPIMLRLKSDLVELCLKACDGKLDEVISQWDLRASLGIVLAAEGYPKDYRKGDEISGL 354
Query: 352 NEEAIKEEGAKIVYASVDENMKLL---GSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+ A+K E K+ A V E L G R L + + +++ EA++ A ++
Sbjct: 355 PKSAVKNE--KVFLAGVAEQEGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQWSGR 412
Query: 408 FYRKDVGTKESIEKRIR 424
FYR+D+G + ++E+ ++
Sbjct: 413 FYRRDIGYR-AVERELQ 428
>dbj|BAA89446.1| (AB003161) 5'-phosphoribosylglycinamide synthetase [Corynebacterium
ammoniagenes]
Length = 426
Score = 209 bits (527), Expect = 4e-53
Identities = 145/434 (33%), Positives = 217/434 (49%), Gaps = 40/434 (9%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPG------LARISRDYGISKETDVEK 54
MR+L++G GGREHAI + LA A+ H PG LA + DY + D +
Sbjct: 1 MRILVIGSGGREHAILKGLA---ADPATTDLHVAPGSPAFASLATVHADY--KEVADPAR 55
Query: 55 VVRFARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERN 114
++ A+ +L IGPE PL AG+ + L EGI GP +AA++E +KA+A+E ME
Sbjct: 56 MLELAQDIKPELVVIGPEIPLVAGVADTLRAEGIAVFGPNADAAQIEGSKAFAKEVMEAA 115
Query: 115 DIPGRKLFKV-----FDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAK 169
+ + + DD+E +D +G VVK GL GKGV V D EA+
Sbjct: 116 GVATARAQTLPPGMTDDDIEHE---LDYFGPMYVVKDDGLAAGKGVVVTA----DRAEAR 168
Query: 170 EYAEYLIKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMG 229
++ + VL+E DG E + DG V+P+ QD+ AY+ D GP TGGMG
Sbjct: 169 QHIHLVHAAGNPVLLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMG 228
Query: 230 SYSCSNHILPFITKEDWKMALRTLEETI-KAMRKEGYPYKGILYGQFMLSREGPVIIEYN 288
+Y+ LP+++ E +R + E + K M + G PY G+LY +EGP +IE+N
Sbjct: 229 AYTP----LPWLSAEGVDRIVREVCEPVAKQMVERGTPYSGLLYAGLAWGQEGPSVIEFN 284
Query: 289 ARFGDPEAINVLSILEDNLVEIAEGIVKG---RVRGAKFQEKATVVKYLAPKGYPENPIR 345
RFGDPE +LS+L+ L + + G + ++++ V LA YPE+P +
Sbjct: 285 CRFGDPETQPLLSLLKTPLAGVLNAVATGTLDELPALEWEDAYAVTVVLAAANYPESPRK 344
Query: 346 GAEI----MVNEEAIKEEGAKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIR 401
G I + + + I G + A V N G R L ++G +TL A A +
Sbjct: 345 GDAITSPDLADTDKILHAGTAVKDAEVISN----GGRVLNVIGKGETLSAARAAAYEVLE 400
Query: 402 HVR-GPVFYRKDVG 414
++ FYR D+G
Sbjct: 401 NIELADSFYRTDIG 414
>sp|Q9ZF44|PUR2_LACLA PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|3892883|emb|CAA04374.1| (AJ000883) purD
[Lactococcus lactis]
Length = 412
Score = 209 bits (526), Expect = 6e-53
Identities = 140/423 (33%), Positives = 218/423 (51%), Gaps = 20/423 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M++L++G GGREHA+ + V N G+ + E +K+V+FA+
Sbjct: 1 MKILVIGSGGREHALAKKFMESPQVEEVFVAPGNSGMEKDGIQIVHISELSNDKLVKFAQ 60
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
N+ L F+GPE L G+V+A + +P GP K AA LE +K +A+ M++ +P
Sbjct: 61 NQNIGLTFVGPETALMNGVVDAFIKAELPIFGPNKMAAELEGSKDFAKSIMKKYGVPTAD 120
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE-YAEYLIKKD 179
+ FD +E A++DE G P+V+K GL GKGV V D E AK A+
Sbjct: 121 -YATFDSLEPALAYLDEKGVPLVIKADGLAAGKGVTVAF----DIETAKSALADIFSGSQ 175
Query: 180 GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILP 239
GKV+IEE DG EF+ F + PMP+ QD+ A++ D GP TGGMG+YS HI
Sbjct: 176 GKVVIEEFLDGEEFSLFSFIHDGKIYPMPIAQDHKRAFDEDKGPNTGGMGAYSPVLHISK 235
Query: 240 FITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAINV 299
+ E + + ++ T+ M +EG + G+LY +L+ +G IE+NARFGDPE V
Sbjct: 236 EVVNEALE---KVVKPTVAGMIEEGKSFTGVLYAGLILTEDGVKTIEFNARFGDPETQVV 292
Query: 300 LSILEDNLVEIAEGIVKGRVRGAKFQEK-ATVVKYLAPKGYPENPIRGAEIMVNEEAIKE 358
L L+ +L + I+ G ++ E T+ +A +GYP G ++ E
Sbjct: 293 LPRLKSDLAQAIIDILAGNEPTLEWLESGVTLGVVVAAEGYPSQAKLG---LILPEI--P 347
Query: 359 EGAKIVYASV--DENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHVRGP-VFYRKDV 413
EG + YA V +EN +L+ G R + + ++ +K+ + + FYR D+
Sbjct: 348 EGLNVYYAGVSKNENNQLISSGGRVYLVSETGEDVKSTQKLLYEKLDKLENDGFFYRHDI 407
Query: 414 GTK 416
G++
Sbjct: 408 GSR 410
>sp|P15640|PUR2_ECOLI PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|68646|pir||AJECQG
phosphoribosylamine--glycine ligase (EC 6.3.4.13) -
Escherichia coli >gi|42596|emb|CAA36213.1| (X51950) purD
gene product [Escherichia coli]
>gi|396344|gb|AAC43103.1| (U00006)
phosphoribosylglycineamide synthetase [Escherichia coli]
>gi|1790438|gb|AAC76979.1| (AE000473)
phosphoribosylglycinamide synthetase = GAR synthetase
[Escherichia coli K12]
Length = 429
Score = 209 bits (526), Expect = 6e-53
Identities = 142/427 (33%), Positives = 228/427 (53%), Gaps = 20/427 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGIS-KETDVEKVVRFA 59
M+VL++G GGREHA+ A+ V N G A ++ TD+ ++ FA
Sbjct: 1 MKVLVIGNGGREHALAWKAAQSPLVETVFVAPGNAGTALEPALQNVAIGVTDIPALLDFA 60
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
+ +DL +GPEAPL G+V+ G+ GPT AA+LE +KA+ ++F+ R+ IP
Sbjct: 61 QNEKIDLTIVGPEAPLVKGVVDTFRAAGLKIFGPTAGAAQLEGSKAFTKDFLARHKIPTA 120
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE--YAEYLIK 177
+ ++ F +VE A++ E G P+V+K GL GKGV +V L++ E A A
Sbjct: 121 E-YQNFTEVEPALAYLREKGAPIVIKADGLAAGKGV-IVAMTLEEAEAAVHDMLAGNAFG 178
Query: 178 KDG-KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
G +++IEE DG E +F V DG +V+PM QD+ + D GP TGGMG+YS +
Sbjct: 179 DAGHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGDKDTGPNTGGMGAYSPA-- 236
Query: 237 ILPFITKEDWKMAL-RTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
P +T + + + R + T+K M EG Y G LY M+ ++G P +IE+N RFGDP
Sbjct: 237 --PVVTDDVHQRTMERIIWPTVKGMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCRFGDP 294
Query: 295 EAINVLSILEDNLVEIAEGIVKGRV--RGAKFQEKATVVKYLAPKGYPENPIRGAEIMVN 352
E ++ ++ +LVE+ + ++ + +++ E+A++ +A GYP R +++
Sbjct: 295 ETQPIMLRMKSDLVELCLAACESKLDEKTSEWDERASLGVVMAAGGYP-GDYRTGDVIHG 353
Query: 353 EEAIKEEGAKIVYASV----DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+ G K+ +A DE + G R L + + T+ EA+K A A + +
Sbjct: 354 LPLEEVAGGKVFHAGTKLADDEQVVTNGGRVLCVTALGHTVAEAQKRAYALMTDIHWDDC 413
Query: 408 FYRKDVG 414
F RKD+G
Sbjct: 414 FCRKDIG 420
>gb|AAA24455.1| (J05126) purD (EC 6.3.4.13) [Escherichia coli]
Length = 429
Score = 206 bits (519), Expect = 4e-52
Identities = 142/427 (33%), Positives = 227/427 (52%), Gaps = 20/427 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGIS-KETDVEKVVRFA 59
M+VL++G GGREHA A+ V N G A ++ TD+ ++ FA
Sbjct: 1 MKVLVIGNGGREHAWRWKAAQSPLVETVFVAPGNAGTALEPALQNVAIGVTDIPALLDFA 60
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
+ +DL +GPEAPL G+V+ G+ GPT AA+LE +KA+ ++F+ R+ IP
Sbjct: 61 QNEKIDLTIVGPEAPLVKGVVDTFRAAGLKIFGPTAVAAQLEGSKAFTKDFLARHKIPTA 120
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE--YAEYLIK 177
+ ++ F +VE A++ E G P+V+K GL GKGV +V L++ E A A
Sbjct: 121 E-YQNFTEVEPALAYLREKGAPIVIKADGLAAGKGV-IVAMTLEEAEAAVHDMLAGNAFG 178
Query: 178 KDG-KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
G +++IEE DG E +F V DG +V+PM QD+ + D GP TGGMG+YS +
Sbjct: 179 DAGHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGDKDTGPNTGGMGAYSPA-- 236
Query: 237 ILPFITKEDWKMAL-RTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
P +T + + + R + T+K M EG Y G LY M+ ++G P +IE+N RFGDP
Sbjct: 237 --PVVTDDVHQRTMERIIWPTVKGMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCRFGDP 294
Query: 295 EAINVLSILEDNLVEIAEGIVKGRV--RGAKFQEKATVVKYLAPKGYPENPIRGAEIMVN 352
E ++ ++ +LVE+ + ++ + +++ E+A++ +A GYP R +++
Sbjct: 295 ETQPIMLRMKSDLVELCLAACESKLDEKTSEWDERASLGVVMAAGGYP-GDYRTGDVIHG 353
Query: 353 EEAIKEEGAKIVYASV----DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+ G K+ +A DE + G R L + + T+ EA+K A A + +
Sbjct: 354 LPLEEVAGGKVFHAGTKLADDEQVVTNGGRVLCVTALGHTVAEAQKRAYALMTDIHWDDC 413
Query: 408 FYRKDVG 414
F RKD+G
Sbjct: 414 FCRKDIG 420
>pir||E81000 phosphoribosylamine--glycine ligase NMB2151 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7227409|gb|AAF42459.1| (AE002563)
phosphoribosylamine--glycine ligase [Neisseria
meningitidis MC58]
Length = 423
Score = 206 bits (519), Expect = 4e-52
Identities = 142/429 (33%), Positives = 225/429 (52%), Gaps = 23/429 (5%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M++L++G GGREHA+ LA+ V N G A + I T + ++ F R
Sbjct: 1 MKLLVIGNGGREHALAWKLAQSPKVETVFVAPGNAGTAIEPKLQNIDL-TAHQDLIEFCR 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
N+ +GPEAPL AGIV+ G+ GPT+ AA+LE++K +A+ FM + +IP +
Sbjct: 60 KENIVFTVVGPEAPLAAGIVDDFRAAGLKIFGPTQYAAQLESSKDFAKAFMAKYNIPTAQ 119
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG 180
++ F++ + ++++ G P+V+K GL GKGV V D A L K G
Sbjct: 120 -YQTFENADAAHDYVNQKGAPIVIKADGLAAGKGVIVA--MTLDEAHAAIDDMLLDNKMG 176
Query: 181 ----KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
+V+IE+ G E +F V DG NV+PM QD+ +GD G TGGMG+YS +
Sbjct: 177 NAGARVVIEDFLQGEEASFIVMVDGNNVLPMATSQDHKRLLDGDKGLNTGGMGAYSPA-- 234
Query: 237 ILPFITKEDWKMAL-RTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
P +T ++ A+ + T+ M+ EG+ + G LY M+ + G P IE+N RFGDP
Sbjct: 235 --PVVTPVVYERAMNEIILPTVAGMKAEGHEFTGFLYAGLMIDQSGAPYTIEFNCRFGDP 292
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVRG--AKFQEKATVVKYLAPKGYPENPIRGAEIMVN 352
E ++S L +L ++ E + G++ A++ + V LA + YPE P +G +I+
Sbjct: 293 ETQPIMSRLNSDLSDLVEAAIDGKLDSVTAEWSPQTAVGVVLAAQNYPETPKKG-DIISG 351
Query: 353 EEAIKEEGAKIVYASVDENMK----LLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+A + G K+ +A N K G R L +VG+ D + +A+ A + + +
Sbjct: 352 LDAANQIG-KVFHAGTTANEKGDVLTNGGRVLCVVGLGDNVAQAKAKAYGALEKISFDGM 410
Query: 408 FYRKDVGTK 416
YRKD+ K
Sbjct: 411 QYRKDIADK 419
>gb|AAG02154.1|AF212041_10 (AF212041) phosphoribosylamine-glycine liase [Zymomonas mobilis]
Length = 416
Score = 206 bits (519), Expect = 4e-52
Identities = 137/424 (32%), Positives = 218/424 (51%), Gaps = 19/424 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M VLL+G GGREHA+ +A+ + + NPG+A++++ I+ TD VVRF +
Sbjct: 1 MNVLLIGTGGREHALAWKIAQSPSLDTFYATTGNPGIAKLAKPADITV-TDHAAVVRFCQ 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREF--MERNDIPG 118
+DL IGPEAPL G+ N+L + +GPTK+ + R ++ +D P
Sbjct: 60 DNAIDLVVIGPEAPLVDGLGNSLRAALLRFLGPTKQRPSRRLKRFHKRSLRPLQYSDCP- 118
Query: 119 RKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKK 178
EE KA +D + PVV+K GL GGKGV + +L+ + ++ K
Sbjct: 119 ---LSTCRSAEEAKAALDNFSTPVVIKADGLAGGKGVIIAESRLEAEQAIQDMTAGAFGK 175
Query: 179 DG-KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHI 237
G ++++EE G E +F SDG V P +D+ +GD GP TGGMG+YS + +
Sbjct: 176 AGLEIVVEEFMQGEEASFFAISDGETVRPFGTARDHKRVGDGDTGPNTGGMGAYSPATSL 235
Query: 238 LPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAI 297
+ K ++ + T++AM+++G P+ GILY ML+ EGP +IEYNAR GDPE
Sbjct: 236 TADLEK---RVMQEIVTPTVQAMKEQGMPFVGILYAGLMLTSEGPKLIEYNARLGDPECQ 292
Query: 298 NVLSILEDNLVEIAEGIVKGRVRG---AKFQEKATVVKYLAPKGYPENPIRGAEIMVNEE 354
++ LE +++ + G+++ F + V +A +GYP +P +G I E
Sbjct: 293 VLMMRLESDILPLLYAAATGKLQAQPEPTFSKDYAVTVVIAAQGYPASPKKGGIITRLNE 352
Query: 355 AIKEEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGP-VFYR 410
A + GA + A ++ +K G R L + A A +A + + P F+R
Sbjct: 353 A-EANGAVVFQAGTTLDNQTLKANGGRVLNVTAKAADFNAARYLAYQAVNVIVYPDGFWR 411
Query: 411 KDVG 414
+D+G
Sbjct: 412 EDIG 415
>pdb|1GSO|A Chain A, Glycinamide Ribonucleotide Synthetase (Gar-Syn) From E.
Coli
Length = 431
Score = 205 bits (516), Expect = 9e-52
Identities = 141/427 (33%), Positives = 227/427 (53%), Gaps = 20/427 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGIS-KETDVEKVVRFA 59
M+VL++G GGREHA+ A+ V N G A ++ TD+ ++ FA
Sbjct: 3 MKVLVIGNGGREHALAWKAAQSPLVETVFVAPGNAGTALEPALQNVAIGVTDIPALLDFA 62
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
+ +DL +GPEAPL G+V+ G+ GPT AA+LE +KA+ ++F+ R+ IP
Sbjct: 63 QNEKIDLTIVGPEAPLVKGVVDTFRAAGLKIFGPTAGAAQLEGSKAFTKDFLARHKIPTA 122
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE--YAEYLIK 177
+ ++ F +VE A++ E G P+V+K GL GKGV +V L++ E A A
Sbjct: 123 E-YQNFTEVEPALAYLREKGAPIVIKADGLAAGKGV-IVAMTLEEAEAAVHDMLAGNAFG 180
Query: 178 KDG-KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
G +++IEE DG E +F V DG +V+PM QD+ + D GP TGGMG+YS +
Sbjct: 181 DAGHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGDKDTGPNTGGMGAYSPA-- 238
Query: 237 ILPFITKEDWKMAL-RTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
P +T + + + R + T+K M EG Y G LY M+ ++G P +IE+N RFGD
Sbjct: 239 --PVVTDDVHQRTMERIIWPTVKGMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCRFGDL 296
Query: 295 EAINVLSILEDNLVEIAEGIVKGRV--RGAKFQEKATVVKYLAPKGYPENPIRGAEIMVN 352
E ++ ++ +LVE+ + ++ + +++ E+A++ +A GYP R +++
Sbjct: 297 ETQPIMLRMKSDLVELCLAACESKLDEKTSEWDERASLGVVMAAGGYP-GDYRTGDVIHG 355
Query: 353 EEAIKEEGAKIVYASV----DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+ G K+ +A DE + G R L + + T+ EA+K A A + +
Sbjct: 356 LPLEEVAGGKVFHAGTKLADDEQVVTNGGRVLCVTALGHTVAEAQKRAYALMTDIHWDDC 415
Query: 408 FYRKDVG 414
F RKD+G
Sbjct: 416 FCRKDIG 422
>pir||B82018 phosphoribosylamine--glycine ligase (EC 6.3.4.13) NMA0238
[imported] - Neisseria meningitidis (group A strain
Z2491) >gi|7379000|emb|CAB83546.1| (AL162752)
phosphoribosylamine--glycine ligase [Neisseria
meningitidis Z2491]
Length = 423
Score = 205 bits (516), Expect = 9e-52
Identities = 140/429 (32%), Positives = 225/429 (51%), Gaps = 23/429 (5%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M++L++G GGREHA+ LA+ V N G A + I T + ++ F R
Sbjct: 1 MKLLVIGNGGREHALAWKLAQSPKVETVFVAPGNAGTAIEPKLQNIDL-TAHQDLIEFCR 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
N+ +GPEAPL AG+V+ G+ GPT+ AA+LE++K +A+ FM + +IP +
Sbjct: 60 KENIVFTVVGPEAPLAAGVVDDFRAAGLKIFGPTQYAAQLESSKDFAKAFMAKYNIPTAQ 119
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG 180
++ F++ + ++++ G P+V+K GL GKGV V D A L K G
Sbjct: 120 -YQTFENADAAHDYVNQKGAPIVIKADGLAAGKGVIVA--MTLDEAHAAIDDMLLDNKMG 176
Query: 181 ----KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
+V+IE+ G E +F V DG NV+PM QD+ +GD G TGGMG+YS +
Sbjct: 177 NAGARVVIEDFLQGEEASFIVMVDGNNVLPMATSQDHKRLLDGDKGLNTGGMGAYSPA-- 234
Query: 237 ILPFITKEDWKMAL-RTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
P +T ++ A+ + T+ M+ EG+ + G LY M+ + G P IE+N RFGDP
Sbjct: 235 --PVVTPVVYERAMNEIILPTVAGMKAEGHEFTGFLYAGLMIDQSGAPHTIEFNCRFGDP 292
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVRG--AKFQEKATVVKYLAPKGYPENPIRGAEIMVN 352
E ++S L +L ++ E + G++ A++ + V LA + YPE P +G +++
Sbjct: 293 ETQPIMSRLNSDLSDLVEAAIDGKLDSVTAEWSPQTAVGVVLAAQNYPETPKKG-DVISG 351
Query: 353 EEAIKEEGAKIVYASVDENMK----LLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+A + G K+ +A N K G R L +VG+ D + +A+ A + + +
Sbjct: 352 LDAANQVG-KVFHAGTTANEKGDVLTNGGRVLCVVGLGDNVAQAKAKAYGALEKISFDGM 410
Query: 408 FYRKDVGTK 416
YRKD+ K
Sbjct: 411 QYRKDIADK 419
>pir||D82614 glycinamide ribonucleotide synthetase XF1976 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107084|gb|AAF84778.1|AE004017_1 (AE004017)
glycinamide ribonucleotide synthetase [Xylella
fastidiosa]
Length = 437
Score = 199 bits (500), Expect = 7e-50
Identities = 137/443 (30%), Positives = 229/443 (50%), Gaps = 21/443 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGIS-KETDVEKVVRFA 59
M++L++G GGREHA+ LA ++ N G A ++ K TD++ ++ A
Sbjct: 1 MKLLVIGSGGREHALAWKLAHSRRVSEIIVAPGNAGTATETKCRNAPVKVTDLDGLLALA 60
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
+ V++ +GPE PL AGIV+ G+ GPT AA+LE +KA+A++F+ R+ IP
Sbjct: 61 QREAVNITVVGPEVPLVAGIVDCFRAAGMRIFGPTAAAAQLEGSKAYAKDFLARHGIPTA 120
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKE---YAEYLI 176
+ + V +V+ + + + G P+V+K GL GKGV +V + + E A
Sbjct: 121 R-YAVHTNVDAAISDVRQQGAPIVIKADGLAAGKGV-IVAMTVTEAEAAIRDMLSGNAFG 178
Query: 177 KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNH 236
+V+IEE DG E +F DG + +PM QD+ +GD+GP TGGMG+YS +
Sbjct: 179 HAGARVVIEEYLDGEEASFISMVDGTHALPMATSQDHKRVSDGDIGPNTGGMGAYSPA-- 236
Query: 237 ILPFITKEDWKMALRTL-EETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGDP 294
P IT E +R + T+ M +G P+ G LY M+ G P +IE+N RFGDP
Sbjct: 237 --PIITDEIHARVMREIVNPTVTGMIADGTPFMGFLYAGLMIDVHGAPKVIEFNVRFGDP 294
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVR--GAKFQEKATVVKYLAPKGYPENPIRGAEIMVN 352
E ++ L+ +L+++ E + G + A++ + ++ +A + YP+ PI G EI+
Sbjct: 295 ETQPMMMRLQSDLLDLIEAALNGDLDKVQAQWDPRPSLGVVMAARPYPKAPITG-EIISG 353
Query: 353 EEAIKEEGAKIVYASVDEN----MKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR-GPV 407
+A+ K+ +A + + G R L + + + EA++ A AG+ +
Sbjct: 354 LDAL-PANVKVFHAGTALDAAGCVVTAGGRVLCVTALGSNVSEAQRHAYAGVASLHWANA 412
Query: 408 FYRKDVGTKESIEKRIRTMKELG 430
F R D+G + + + T+ G
Sbjct: 413 FQRSDIGWRAIMREHTVTLNVHG 435
>sp|Q50144|PUR2_MYCLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|699375|gb|AAA63135.1| (U15187)
phosphoribosylamine-glycine ligase [Mycobacterium
leprae] >gi|2076615|emb|CAB08419.1| (Z95151) PurD
[Mycobacterium leprae]
Length = 422
Score = 197 bits (496), Expect = 2e-49
Identities = 143/426 (33%), Positives = 216/426 (50%), Gaps = 26/426 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
MRVL++G G REHA+ AL+R +V N G AR++ Y + + E +V AR
Sbjct: 1 MRVLVIGSGAREHALLLALSRDPQVKGLVVAPGNAGTARLAEQYDVDISSG-EDIVALAR 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
D+ IGPE PL G+ +A+ GI GP+K+AAR+E +KA+A+E M + +
Sbjct: 60 DVRADMVVIGPELPLVLGVADAVRAAGIVCFGPSKDAARIEGSKAFAKEVMAAAGVRTSR 119
Query: 121 LFKVFDDVEEMKAWIDEYGKPV-----VVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYL 175
++ + + A +D +G PV VVK L GKGV V D + A+ +A L
Sbjct: 120 S-EIVNSPARLDAALDRFGPPVGDLSWVVKDDRLAAGKGVVVTS----DRDVARTHAAGL 174
Query: 176 IKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSN 235
++ VL+E DG E + DGR V+P+ QD+ EGD GP TGGMG+Y+
Sbjct: 175 LEAGHPVLLESYLDGPEVSLFCVVDGRTVLPLLPAQDFKRVGEGDTGPNTGGMGAYA--- 231
Query: 236 HILPFITKEDWKMALRTLEETIKA-MRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDP 294
LP++ E + AL ++ E + A + + G P++G+LY ++ GP ++E+N RFGDP
Sbjct: 232 -PLPWLPDEVCQQALTSIVEPVAAELVQRGSPFRGLLYVGLAVTASGPAVVEFNCRFGDP 290
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVRG---AKFQEKATVVKYLAPKGYPENPIRGAEIMV 351
E VL++L+ L ++ G + ++ A V LA + YP P G +
Sbjct: 291 ETQVVLALLDSPLGQLLYAAGTGSLADFGELHWRSGAAVAVVLAAENYPRRPRVGDIVFG 350
Query: 352 NE-EAIKEEGAKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR--GPVF 408
+E E + G D + G R L++V D L A A I +R G F
Sbjct: 351 SEIEGVLHAGTT---RRDDGVIVSSGGRVLSVVATGDDLSAARSQAYRIIGSIRLLGSHF 407
Query: 409 YRKDVG 414
RKD+G
Sbjct: 408 -RKDIG 412
>sp|P00967|PUR2_DROME TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68649|pir||AJFFPM
purine synthesis multifunctional protein - fruit fly
(Drosophila melanogaster) >gi|157482|gb|AAA28563.1|
(J02527) Gart polypeptide 4.7 kb transcript [Drosophila
melanogaster] >gi|295747|emb|CAA29612.1| (X06286)
GARS-AIRS-GART polypeptide [Drosophila melanogaster]
Length = 1353
Score = 194 bits (489), Expect = 1e-48
Identities = 132/443 (29%), Positives = 223/443 (49%), Gaps = 55/443 (12%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET----DVEKVVR 57
RVL++G GGREHAI L++ + + + G+ + + + +T D E + +
Sbjct: 4 RVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAK 63
Query: 58 FARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIP 117
+++ + L +GPE PL G+ + L+ GIP GP K+ A++E +K WA++FM R+ IP
Sbjct: 64 WSKENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIP 123
Query: 118 GRKLFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI 176
+ ++ F D E+ KA+I P +VVK GL GKGV V + +EA + + ++
Sbjct: 124 TAR-YESFTDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAA----NAKEACQAVDEIL 178
Query: 177 ------KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGS 230
+ +++EE +G E + F+DG++V M QD+ GD GP TGGMG+
Sbjct: 179 GDLKYGQAGATLVVEELLEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGA 238
Query: 231 YSCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNA 289
Y C P I++ ++ + LE ++ + KE Y+G+LY ML+R+GP ++E+N
Sbjct: 239 Y-CP---CPLISQPALELVQKAVLERAVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNC 294
Query: 290 RFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAKFQEK---ATVVKYLAPKGYPENPIRG 346
RFGDPE +L +LE +L ++ E G++ Q + + V LA GYPE +G
Sbjct: 295 RFGDPETQVILPLLESDLFDVMEACCSGKLDKIPLQWRNGVSAVGVILASAGYPETSTKG 354
Query: 347 A--------------------EIMVNEEAIKEEGAKIVYASVDENMKLLGSRALAMVGV- 385
+ +EA+ G ++ ++D ++K ++A + G
Sbjct: 355 CIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGRVLIAIALDGSLKEAAAKATKLAGSI 414
Query: 386 ----------ADTLEEAEKIAEA 398
D ++A KIA A
Sbjct: 415 SFSGSGAQYRTDIAQKAFKIASA 437
>gb|AAF52474.1| (AE003615) ade3 gene product [Drosophila melanogaster]
Length = 1747
Score = 194 bits (489), Expect = 1e-48
Identities = 132/443 (29%), Positives = 223/443 (49%), Gaps = 55/443 (12%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET----DVEKVVR 57
RVL++G GGREHAI L++ + + + G+ + + + +T D E + +
Sbjct: 398 RVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAK 457
Query: 58 FARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIP 117
+++ + L +GPE PL G+ + L+ GIP GP K+ A++E +K WA++FM R+ IP
Sbjct: 458 WSKENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIP 517
Query: 118 GRKLFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI 176
+ ++ F D E+ KA+I P +VVK GL GKGV V + +EA + + ++
Sbjct: 518 TAR-YESFTDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAA----NAKEACQAVDEIL 572
Query: 177 ------KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGS 230
+ +++EE +G E + F+DG++V M QD+ GD GP TGGMG+
Sbjct: 573 GDLKYGQAGATLVVEELLEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGA 632
Query: 231 YSCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNA 289
Y C P I++ ++ + LE ++ + KE Y+G+LY ML+R+GP ++E+N
Sbjct: 633 Y-CP---CPLISQPALELVQKAVLERAVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNC 688
Query: 290 RFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAKFQEK---ATVVKYLAPKGYPENPIRG 346
RFGDPE +L +LE +L ++ E G++ Q + + V LA GYPE +G
Sbjct: 689 RFGDPETQVILPLLESDLFDVMEACCSGKLDKIPLQWRNGVSAVGVILASAGYPETSTKG 748
Query: 347 A--------------------EIMVNEEAIKEEGAKIVYASVDENMKLLGSRALAMVGV- 385
+ +EA+ G ++ ++D ++K ++A + G
Sbjct: 749 CIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGRVLIAIALDGSLKEAAAKATKLAGSI 808
Query: 386 ----------ADTLEEAEKIAEA 398
D ++A KIA A
Sbjct: 809 SFSGSGAQYRTDIAQKAFKIASA 831
>gb|AAA28562.1| (J02527) Gart polypeptide 1.7 kb transcript [Drosophila
melanogaster]
Length = 434
Score = 194 bits (488), Expect = 2e-48
Identities = 126/418 (30%), Positives = 215/418 (51%), Gaps = 44/418 (10%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET----DVEKVVR 57
RVL++G GGREHAI L++ + + + G+ + + + +T D E + +
Sbjct: 4 RVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAK 63
Query: 58 FARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIP 117
+++ + L +GPE PL G+ + L+ GIP GP K+ A++E +K WA++FM R+ IP
Sbjct: 64 WSKENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIP 123
Query: 118 GRKLFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI 176
+ ++ F D E+ KA+I P +VVK GL GKGV V + +EA + + ++
Sbjct: 124 TAR-YESFTDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAA----NAKEACQAVDEIL 178
Query: 177 ------KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGS 230
+ +++EE +G E + F+DG++V M QD+ GD GP TGGMG+
Sbjct: 179 GDLKYGQAGATLVVEELLEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGA 238
Query: 231 YSCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNA 289
Y C P I++ ++ + LE ++ + KE Y+G+LY ML+R+GP ++E+N
Sbjct: 239 Y-CP---CPLISQPALELVQKAVLERAVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNC 294
Query: 290 RFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAKFQEK---ATVVKYLAPKGYPENPIRG 346
RFGDPE +L +LE +L ++ E G++ Q + + V LA GYPE +G
Sbjct: 295 RFGDPETQVILPLLESDLFDVMEACCSGKLDKIPLQWRNGVSAVGVILASAGYPETSTKG 354
Query: 347 A--------------------EIMVNEEAIKEEGAKIVYASVDENMKLLGSRALAMVG 384
+ +EA+ G ++ ++D ++K ++A + G
Sbjct: 355 CIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGRVLIAIALDGSLKEAAAKATKLAG 412
>sp|P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68650|pir||AJFFPP
purine synthesis multifunctional protein - fruit fly
(Drosophila pseudoobscura) >gi|295787|emb|CAA29611.1|
(X06285) GARS-AIRS-GART polypeptide [Drosophila
pseudoobscura]
Length = 1364
Score = 193 bits (486), Expect = 3e-48
Identities = 125/417 (29%), Positives = 215/417 (50%), Gaps = 44/417 (10%)
Query: 3 VLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISR----DYGISKETDVEKVVRF 58
VL++G GGREHAI L++ + + + G+ ++ + D + D E + ++
Sbjct: 5 VLVIGSGGREHAICWKLSQSTLVKQIYALPGSFGIQQVEKCRNLDAKVLDPKDFEAIAKW 64
Query: 59 ARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPG 118
++ + L +GPE PL G+ + L++EGIP GP K+ A++E +K WA++FM R+ IP
Sbjct: 65 SKKNEISLVVVGPEDPLALGLGDVLQKEGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPT 124
Query: 119 RKLFKVFDDVEEMKAWIDEYG-KPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI- 176
+ ++ F D + KA+I + +VVK GL GKGV V + +EA + + ++
Sbjct: 125 AR-YESFTDTNKAKAFIRSAPYQALVVKAAGLAAGKGVVVAA----NVDEACQAVDEILG 179
Query: 177 -----KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY 231
+ +++EE +G E + F+DG++V M QD+ GD GP TGGMG+Y
Sbjct: 180 DLKYGQAGATLVVEELLEGEEISVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAY 239
Query: 232 SCSNHILPFITKEDWKMALR-TLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNAR 290
C P I++ ++ R LE ++ + KE Y+G+LY ML+R+GP ++E+N R
Sbjct: 240 -CP---CPLISQPALELVQRAVLERAVQGLIKERITYQGVLYAGLMLTRDGPRVLEFNCR 295
Query: 291 FGDPEAINVLSILEDNLVEIAEGIVKGRVRGAKFQEK---ATVVKYLAPKGYPENPIRGA 347
FGDPE +L +LE +L E+ + G++ Q + + V LA GYPE +G
Sbjct: 296 FGDPETQVILPLLETDLFEVMQACCSGQLDRLPLQWRSGVSAVGVVLASAGYPETSTKGC 355
Query: 348 --------------------EIMVNEEAIKEEGAKIVYASVDENMKLLGSRALAMVG 384
+ +EA+ G ++ ++D ++K ++A + G
Sbjct: 356 LITGLPDVNSPTQLIFHSGLSVNKQKEALTNGGRVLIAIALDASLKEAAAKATKLAG 412
>sp|Q99148|PUR2_YARLI BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADE1 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORIBOSYL-AM>
>gi|1117927|gb|AAA85393.1| (U40565) Ade1p [Yarrowia
lipolytica]
Length = 788
Score = 192 bits (484), Expect = 5e-48
Identities = 141/431 (32%), Positives = 219/431 (50%), Gaps = 21/431 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGL----ARISRDYGISKETDVEKVV 56
+R+LLVG GGREHA+ LA+ + N G +I S + D K+V
Sbjct: 3 LRILLVGNGGREHALAWKLAQSPLVERIFVAPGNGGTDNPQGKIENIAIGSSQKDFAKLV 62
Query: 57 RFARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDI 116
FA+ +V L GPE PL GI + GIP GP+++AA +E +K ++++FM++++I
Sbjct: 63 EFAQSKDVGLVIPGPEQPLVEGIETHFRKVGIPVFGPSEKAAVMEGSKTFSKDFMKKHNI 122
Query: 117 PGRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAE--Y 174
P F+ F D + ++ + G VV+K GL GKGV + + KE +
Sbjct: 123 P-TAAFENFTDYNKAVDYVKKVGHRVVIKASGLAAGKGVLIPTSTEEAIAAVKEVMQDKA 181
Query: 175 LIKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
+ +V+IEE +G E + FSDG V+ MP QD+ +GD G TGGMG+Y +
Sbjct: 182 FGEAGDEVVIEEFLEGDELSILAFSDGYTVVDMPPAQDHKRIGDGDQGLNTGGMGAYCPA 241
Query: 235 NHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREG-PVIIEYNARFGD 293
P + +E + L+ TI MR++G P+ G+L+ ML+ +G P ++EYN RFGD
Sbjct: 242 PIGTPALLQE---IKESILQPTIDGMRRDGIPFVGMLFTGIMLTPDGKPKVLEYNVRFGD 298
Query: 294 PEAINVLSILED--NLVEIAEGIVKGRVRGAKFQEKA---TVVKYLAPKGYPENPIRGAE 348
PE +L +L D +L E+ V+ R+ + K V ++ GYPE+ +G
Sbjct: 299 PETQTILPLLSDDTDLAEVMLACVERRLDAVTLRVKPDAHAVTVVMSAGGYPESYKKGDA 358
Query: 349 IMVNEEAIKEEGAKIVYASVDENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHVR-G 405
I V + E+ + EN +++ G R +A VA TL++A A G V
Sbjct: 359 ITVG--GLPEQTYIFHAGTASENGQVITAGGRVIASTAVAPTLKDAVAQAYKGADAVEFN 416
Query: 406 PVFYRKDVGTK 416
+ RKD+ K
Sbjct: 417 GKYNRKDIAYK 427
>emb|CAB56348.1| (AL118514) phosphoribosylamine-glycine ligase (EC 6.3.4.13)
[Streptomyces coelicolor A3(2)]
Length = 416
Score = 192 bits (482), Expect = 8e-48
Identities = 132/411 (32%), Positives = 204/411 (49%), Gaps = 21/411 (5%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M+VL++GGG REHA+ +L+ + N G+A ++ + + D V A
Sbjct: 1 MKVLVIGGGAREHALCRSLSLDPDVTALHCAPGNAGIAEVAELHQVDA-LDGAAVTALAG 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
+L +GPEAPL AG+ +A+ GIP GP+ EAARLE +KA+A++ M +P +
Sbjct: 60 RLGAELVVVGPEAPLVAGVADAVREAGIPVFGPSGEAARLEGSKAFAKDVMACAGVPTAR 119
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG 180
+ V + E+ A + +G P VVK GL GKGV V D E A+ +A
Sbjct: 120 SY-VCTNPAEVDAALAAFGAPYVVKDDGLAAGKGVVVT----DDVEAARAHANAC----D 170
Query: 181 KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
+V++EE DG E + +DG NV P+ QD+ A +GD GP TGGMG+YS P
Sbjct: 171 RVVVEEFLDGPEVSLFAVTDGENVRPLQPAQDFKRALDGDEGPNTGGMGAYSPLPWADPK 230
Query: 241 ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAINVL 300
+ E + L+ T+ MR+ G P+ G+LY ++ G +IE+NARFGDPE VL
Sbjct: 231 LVDE---VVQSVLQPTVDEMRRRGTPFSGLLYAGLAITSRGVRVIEFNARFGDPETQVVL 287
Query: 301 SILEDNLVEIAEGIVKGR---VRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAIK 357
+ L+ L + G + ++ ++A V +A YP P G I +E
Sbjct: 288 ARLKTPLAGLLMAAATGNLADLEPLRWSDEAAVTVVVASHNYPGTPRTGDPITGLDEVAA 347
Query: 358 EEG--AKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHV 403
++ A +++A + + G R L++ L EA A + +
Sbjct: 348 QDAPHAYVLHAGTRAEGDAVVSAGGRVLSVTATGADLTEARDRAYRAVARI 398
>gb|AAG09178.1| (AF174494) purine biosynthetic pathway protein ADE5,7
[Kluyveromyces lactis]
Length = 792
Score = 188 bits (472), Expect = 1e-46
Identities = 136/432 (31%), Positives = 223/432 (51%), Gaps = 28/432 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET----DVEKVV 56
+ +L++G GGREHA+ LA+ + + N G A + + + + + +
Sbjct: 3 LNILVLGNGGREHALVWKLAQSASVSTIYVAPGNGGTATVENVVNVPELSPSPENFSALK 62
Query: 57 RFARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDI 116
F N+ L GPE PL GI + GIP GP+ +AA E +K ++++FM++++I
Sbjct: 63 EFVLEKNIGLVVPGPEQPLVDGITQVFQSIGIPVFGPSAKAAIFEGSKTFSKDFMQKHNI 122
Query: 117 PGRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI 176
P + + FDD E KA++++ VV+K G+ GKGV + Q EEA+E + ++
Sbjct: 123 PTAR-YANFDDYEAAKAYLEKVDYQVVLKADGIAAGKGVLIPTTQ----EEAQEALKIIM 177
Query: 177 KKD-----GK-VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGS 230
+ GK V+IEE +G E + SDG + +P QD+ E D G TGGMG+
Sbjct: 178 VERQFGDAGKSVVIEEFLEGDEISILTISDGYSYFNLPPAQDHKRIGENDTGLNTGGMGA 237
Query: 231 YSCSNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNAR 290
Y+ + P + ++ K ++ +I MRK+ P+ G+L+ +L++ GP ++EYN R
Sbjct: 238 YAPAPVATPKLLEQIDKTIVKP---SIDGMRKDKLPFVGVLFTGIILTKNGPKVLEYNVR 294
Query: 291 FGDPEAINVLSIL--EDNLVEIAEGIVKGRVRGAKFQEK----ATVVKYLAPKGYPENPI 344
FGDPE VL +L + +L ++ + R+ + K AT V LA GYPE+
Sbjct: 295 FGDPETQTVLPLLTEDTDLAQVFLAAAEHRLDSVDIKIKDNCYATTV-VLAAGGYPESYK 353
Query: 345 RGAEIMVNEEAIKEEGAKIVYASVDENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRH 402
+G EI V+ I + + +N K+ G R +A VA TL+EA A G+
Sbjct: 354 KGDEITVDSSKIPTDTYIFHAGTKSDNGKVYTNGGRVIASSAVAPTLKEAVDKAYEGVES 413
Query: 403 VR-GPVFYRKDV 413
V+ ++RKD+
Sbjct: 414 VQFSNRYFRKDI 425
>sp|Q26255|PUR2_CHITE TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI>
>gi|254730|gb|AAB23115.1| (S43653) glycinamide
ribonucleotide synthetase, aminoimidazole ribonucleotide
synthetase, glycinamide ribonucleotide transformylase
{EC 6.3.4.13, 6.3.3.1, 2.1.2.2} [Chironomus tentans,
Peptide, 1371 aa]
Length = 1371
Score = 183 bits (460), Expect = 3e-45
Identities = 135/453 (29%), Positives = 227/453 (49%), Gaps = 30/453 (6%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKET----DVEKVVR 57
++LL+G GGREHA+ L + + + + G++++ + ++ D + +
Sbjct: 5 KLLLIGSGGREHALAWKLQQSKNVTEIFAFPGSIGISQLEKVQLVNNNEMNLKDFKGIAS 64
Query: 58 FARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIP 117
+ ++ ++DL +GPE PL GI + L+ I GP+K AR+E++K+W+++FM R+ IP
Sbjct: 65 WCKINHIDLVIVGPEDPLAEGIADQLKAANIHCFGPSKAGARIESDKSWSKDFMIRHHIP 124
Query: 118 GRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI- 176
+ + F D + K +I +VVK GL GKGV V ++ EEA + ++
Sbjct: 125 TAQ-YGSFIDALKAKDFIRNTPNALVVKASGLAAGKGVIVA----ENIEEACAAVDEILG 179
Query: 177 -KKDGK----VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSY 231
K G V++EE+ G E + F D +V +P QD+ + D G TGGMG+Y
Sbjct: 180 DHKFGTAGDVVVVEEKLSGQEVSVLGFVDSNSVRILPPAQDHKRLKDNDEGLNTGGMGAY 239
Query: 232 SCSNHILPFITKEDWKMA-LRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNAR 290
C P I++++ + + L+ + +RKE Y GILY ML+ +GP +E+N R
Sbjct: 240 -CP---CPLISQQELDIVKSQVLQRAVDGLRKENILYNGILYAGIMLTHDGPKTLEFNCR 295
Query: 291 FGDPEAINVLSILEDNLVEIAEGIVKG---RVRGAKFQEKATVV-KYLAPKGYPENPIRG 346
FGDPE +L +L+++L ++ V KF+ V +A KGYPE +G
Sbjct: 296 FGDPETQIILPLLDEDLYDLMMASCTNHLCNVPELKFKSNINAVGVVMASKGYPETSTKG 355
Query: 347 AEIMVNEEAIKEEGAKIVYASVDENMK----LLGSRALAMVGVADTLEEAEKIAEAGIRH 402
I E + + ++ +N K G R L + +AD L++A +A
Sbjct: 356 CVISGIESVETMDNHIVFHSGTSKNNKDEWITNGGRVLINIALADNLKKAADLATKACDV 415
Query: 403 VR-GPVFYRKDVGTKESIEKRIRTMKELGKEFE 434
V+ YR+D+G K++ + T KE G E
Sbjct: 416 VKFDGSQYRRDIG-KKAFQIHSLTYKESGVNIE 447
>sp|Q9X0X7|PUR2_THEMA PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438045|pir||D72277
phosphoribosylamine--glycine ligase - Thermotoga
maritima (strain MSB8)
>gi|4981805|gb|AAD36325.1|AE001780_9 (AE001780)
phosphoribosylamine--glycine ligase [Thermotoga
maritima]
Length = 400
Score = 182 bits (457), Expect = 7e-45
Identities = 141/421 (33%), Positives = 211/421 (49%), Gaps = 34/421 (8%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
+RV ++G GGREHAIG A A+ G E+ H PG A RD G + + EK ++
Sbjct: 4 VRVHILGSGGREHAIGWAFAKQGYEV-----HFYPGNAGTKRD-GTNHPYEGEKTLK--A 55
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
+ D+ G E L G+ N GP KE ARLE +K +A+ FM++ I +
Sbjct: 56 IPEEDIVIPGSEEFLVEGVSNWRSN----VFGPVKEVARLEGSKVYAKRFMKKYGIRTAR 111
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEY--AEYLIKK 178
F+V + EE++ I ++ P V+K GL GKGV ++ + + E+ + E +
Sbjct: 112 -FEVAETPEELREKIKKFSPPYVIKADGLARGKGVLILDSKEETIEKGSKLIIGELIKGV 170
Query: 179 DGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHIL 238
G V+I+E G E + +GRN + +P V+DY +GD GP TGGMGS+
Sbjct: 171 KGPVVIDEFLAGNELSAMAVVNGRNFVILPFVRDYKRLMDGDRGPNTGGMGSWGPVE--- 227
Query: 239 PFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAIN 298
I + K ++T+ + KEGY Y+G LY ML P I+EYN R GDPE
Sbjct: 228 --IPSDTIKKIEELFDKTLWGVEKEGYAYRGFLYLGLMLHDGDPYILEYNVRLGDPETEV 285
Query: 299 VLSILEDNLVE-IAEGIVKGRVRGAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEAIK 357
++++ + V + EG G++ + + A V LA +GYP+ P +G EI + EE +
Sbjct: 286 IVTLNPEGFVNAVLEGYRGGKMEPVEPRGFAVDV-VLAARGYPDAPEKGKEITLPEEGL- 343
Query: 358 EEGAKIVYASV---DENMKLLGSRALAMVGVADTLEEAEKIAE--AGIRHVRGPVFYRKD 412
I +A V D + G R L +G +T EEA + A A H G YR+D
Sbjct: 344 -----IFFAGVAEKDGKLVTNGGRVLHCMGTGETKEEARRKAYELAEKVHFEGKT-YRRD 397
Query: 413 V 413
+
Sbjct: 398 I 398
>sp|P74232|PUR2_SYNY3 PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7428510|pir||S75867
phosphoribosylamine--glycine ligase (EC 6.3.4.13) -
Synechocystis sp. (strain PCC 6803)
>gi|1653412|dbj|BAA18326.1| (D90913) glycinamide
ribonucleotide synthetase [Synechocystis sp.]
Length = 419
Score = 181 bits (455), Expect = 1e-44
Identities = 129/425 (30%), Positives = 207/425 (48%), Gaps = 17/425 (4%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETD-VEKVVRFA 59
M+V ++G GGREH + +L R + N G A + + ++ D + ++ F
Sbjct: 1 MKVAVIGSGGREHTLAWSLVRSPEVSHCYCLPGNGGTAGLPKTENVAIAVDQLGEICEFC 60
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
+ ++L +GPE PL G+ + L+ GI GPTK A LE +K+W ++ + +P
Sbjct: 61 QTEKINLVVVGPELPLTLGLTDQLQALGIKVFGPTKAGAELEASKSWTKQLLIEAGVP-T 119
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD 179
+ F + +A+ + G P+VVK GL GKGV V E AE +
Sbjct: 120 AFGETFTEPAPAQAYATKMGAPIVVKADGLAAGKGVIVA---QTSAEATTAIAELFDQGF 176
Query: 180 GKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILP 239
K+++EE G E + DG+ VIP+ QD+ EGD G TGGMG+Y C I P
Sbjct: 177 EKIVVEEFLPGEEVSVLALCDGKTVIPLLPAQDHKRIGEGDQGLNTGGMGAY-CPAPIAP 235
Query: 240 FITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPV-IIEYNARFGDPEAIN 298
+ ++ + L+ T A+ K G Y+G+LY M+S G + ++EYN RFGDPE
Sbjct: 236 PAVID--QVQKQILQPTANALAKRGIDYRGVLYAGLMVSPTGEIKVLEYNCRFGDPETQA 293
Query: 299 VLSILEDNLVEIAEGIVKGRVR---GAKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEA 355
VL +L L ++ V+ + ++ V +A GYP + +G EI EA
Sbjct: 294 VLPLLATPLEKVLMACVEQNLEQLGPLQWHSGNAVCVVVAAGGYPGSYRKGDEINGLAEA 353
Query: 356 IKEEGAKIVYASVD-ENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHVR-GPVFYRK 411
+ + K+ +A + + K+L G R L + + L A A G+ + ++YR+
Sbjct: 354 -EAQDVKVFHAGTELKEGKVLTNGGRVLGVTALGKDLSTAIATAYRGVEQIDFDGMYYRR 412
Query: 412 DVGTK 416
D+G K
Sbjct: 413 DIGHK 417
>emb|CAC11734.1| (AL445064) phosphoribosylamide-glycine ligase related protein
[Thermoplasma acidophilum]
Length = 219
Score = 181 bits (454), Expect = 2e-44
Identities = 93/201 (46%), Positives = 131/201 (64%)
Query: 2 RVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFARM 61
+V++VG GGRE AI A+ R GA L+ H+NP + +S Y + E D K+ FA
Sbjct: 4 KVMIVGSGGREDAIAMAIKRSGAILFSAIGHENPSIKSLSSKYLVVNELDYRKIEDFAAD 63
Query: 62 WNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRKL 121
VD+ FIGP+ L+ +VN L R GIP PT EAAR+ET+K + RE M+R++IPG
Sbjct: 64 NLVDMVFIGPDPVLDTPLVNNLLRRGIPVASPTMEAARIETSKMFMRELMKRHNIPGNVN 123
Query: 122 FKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDGK 181
F+ E++++ + + G V VKP+GLTGGKGVKVVG QL+ E+A+ YA ++++DG
Sbjct: 124 FRECFSEEDLESALRDLGPEVAVKPIGLTGGKGVKVVGEQLETVEDARRYAIEILRRDGV 183
Query: 182 VLIEERTDGVEFTFQVFSDGR 202
VLIEE+ G EF+ Q F DG+
Sbjct: 184 VLIEEKMVGEEFSLQAFVDGK 204
>gi|11498757 phosphoribosylamine--glycine ligase (purD) [Archaeoglobus fulgidus]
>gi|7994661|sp|O29108|PUR2_ARCFU
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438046|pir||D69394
phosphoribosylamine--glycine ligase (purD) homolog -
Archaeoglobus fulgidus >gi|2649432|gb|AAB90089.1|
(AE001024) phosphoribosylamine--glycine ligase (purD)
[Archaeoglobus fulgidus]
Length = 470
Score = 179 bits (450), Expect = 5e-44
Identities = 147/480 (30%), Positives = 230/480 (47%), Gaps = 81/480 (16%)
Query: 1 MRVLLVGGGGREHAIGEALARGGA--ELYVVSKHKNPGL---ARISRDYG--ISKETDVE 53
M+VL+V GGR +AI A +R E+Y+ + +I+ G I ++
Sbjct: 1 MKVLVVDAGGRGNAIAHAFSRSEQVKEIYIAPGNGGSEFFEKCKIAELDGKKIPSIRAID 60
Query: 54 KVVRFARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMER 113
++VRFA+ VDLA+IGPE PL G+V+ LE EGIP VGP KEA LE +K WA++F++R
Sbjct: 61 EIVRFAKKCEVDLAYIGPEEPLSLGLVDRLEEEGIPAVGPKKEATILEASKCWAKDFLKR 120
Query: 114 NDIPGRKLFKVFDDVEEMKAWI-DEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEA-KEY 171
+P + + FD+ EE K +I +++ +VVK GL GKGV Y EEA +
Sbjct: 121 IGVPIPE-YANFDNPEEAKEYIREKFNNGIVVKADGLAAGKGV----YVCDSVEEALRAV 175
Query: 172 AEYLIKK-----DGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGD------ 220
E +++K ++++EER G+E F +DG+ V P +DY A++ D
Sbjct: 176 DEIMVQKKFGEAGNRIVVEERLRGIEVAFTAMTDGKTVKPFGHARDYKRAFDSDDIEGLR 235
Query: 221 -------------------------VGPITGGMGSYSCSNHILPFITKE-DWKMALRTLE 254
+ P TGGMG+ S P +T+E + ++ +E
Sbjct: 236 DFYIGLTKKFYTKAQIEQLYREGKLINPNTGGMGAVSPH----PAVTEEVEQRIMEMVVE 291
Query: 255 ETIKAMRKEGYPYKGILYGQFMLSREG----PVIIEYNARFGDPEAINVLSILEDNLVEI 310
I+ KE +KG+LY ML E P ++E N R DP A L L+ ++ EI
Sbjct: 292 PIIENFDKE---FKGVLYPVIMLVEENGELIPKVLEINVRDCDPGAEAKLPRLKSDMAEI 348
Query: 311 AEGIVKGRVRGAKFQEKATVVKYLA------------PKGYPENPIRGAEIMVNEEAIKE 358
+ +V+GR+ + + + + GYP + I EEA+KE
Sbjct: 349 SMAVVEGRLDEVEMRFSSDYCVAVCAVSGALKGREGLKPGYPADHYTSQPITGIEEAMKE 408
Query: 359 EGAKIVYA---SVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGP-VFYRKDVG 414
I+YA + G R L +VG+ ++EEA A + + + P + YR+ +G
Sbjct: 409 ---AIIYANGIAKTNGYVTTGGRVLTVVGMGQSIEEARSKAYSALEKISFPGMRYRRTIG 465
>sp|P71827|PUR2_MYCTU PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438050|pir||G70707 probable purD
protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1550650|emb|CAB02384.1| (Z80226) purD [Mycobacterium
tuberculosis]
Length = 422
Score = 179 bits (450), Expect = 5e-44
Identities = 133/430 (30%), Positives = 211/430 (48%), Gaps = 30/430 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
MRVL++G G REHA+ AL + ++ N G ARI+ + + T E VV AR
Sbjct: 1 MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQHDVDI-TSAEAVVALAR 59
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
D+ IGPE PL G+ +A+ GI GP K+AAR+E +KA+A++ M +
Sbjct: 60 EVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPGKDAARIEGSKAFAKDVMAAAGVRTAN 119
Query: 121 LFKVFDDVEEMKAWIDEYGKPV-----VVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYL 175
++ D + A +D +G P VVK L GKGV V D + A+ + L
Sbjct: 120 -SEIVDSPAHLDAALDRFGPPAGDPAWVVKDDRLAAGKGVVVTA----DRDVARAHGAAL 174
Query: 176 IKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSN 235
++ VL+E DG E + D V+P+ QD+ E D G TGGMG+Y+
Sbjct: 175 LEAGHPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYA--- 231
Query: 236 HILPFITKEDWKMALRTLEETIKA-MRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDP 294
LP++ ++ + + E + A + + G + G+LY ++ GP ++E+N RFGDP
Sbjct: 232 -PLPWLPDNIYREVVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDP 290
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVRG---AKFQEKATVVKYLAPKGYPENPIRGAEIMV 351
E VL++LE L ++ G++ ++++ V LA + YP P R +++V
Sbjct: 291 ETQAVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRP-RVGDVVV 349
Query: 352 NEEAIKEEGAKIVYASV----DENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGP- 406
EA EG +++A D + G R L++VG L A A + +R P
Sbjct: 350 GSEA---EG--VLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAHAYEILSSIRLPG 404
Query: 407 VFYRKDVGTK 416
+R D+G +
Sbjct: 405 GHFRSDIGLR 414
>emb|CAA24923.1| (X00041) GART [Drosophila melanogaster]
Length = 1089
Score = 173 bits (434), Expect = 4e-42
Identities = 116/386 (30%), Positives = 195/386 (50%), Gaps = 51/386 (13%)
Query: 55 VVRFARMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERN 114
+ ++++ + L +GPE PL G+ + L+ GIP GP K+ A++E +K WA++FM R+
Sbjct: 2 IAKWSKENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRH 61
Query: 115 DIPGRKLFKVFDDVEEMKAWIDEYGKP-VVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAE 173
IP + ++ F D E+ KA+I P +VVK GL GKGV V + +EA + +
Sbjct: 62 GIPTAR-YESFTDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAA----NAKEACQAVD 116
Query: 174 YLI------KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGG 227
++ + +++EE +G E + F+DG++V M QD+ GD GP TGG
Sbjct: 117 EILGDLKYGQAGATLVVEELLEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGG 176
Query: 228 MGSYSCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREGPVIIE 286
MG+Y C P I++ ++ + LE ++ + KE Y+G+LY ML+R+GP ++E
Sbjct: 177 MGAY-CP---CPLISQPALELVQKAVLERAVQGLIKERINYQGVLYAGLMLTRDGPRVLE 232
Query: 287 YNARFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAKFQEK---ATVVKYLAPKGYPENP 343
+N RFGDPE +L +LE +L ++ E G++ Q + + V LA GYPE
Sbjct: 233 FNCRFGDPETQVILPLLESDLFDVMEACCSGKLDKIPLQWRNGVSAVGVILASAGYPETS 292
Query: 344 IRGA--------------------EIMVNEEAIKEEGAKIVYASVDENMKLLGSRALAMV 383
+G + +EA+ G ++ ++D ++K ++A +
Sbjct: 293 TKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGRVLIAIALDGSLKEAAAKATKLA 352
Query: 384 GV-----------ADTLEEAEKIAEA 398
G D ++A KIA A
Sbjct: 353 GSISFSGSGAQYRTDIAQKAFKIASA 378
>pir||D81332 phosphoribosylamine--glycine ligase (EC 6.3.4.13) Cj1250 [imported]
- Campylobacter jejuni (strain NCTC 11168)
>gi|6968683|emb|CAB73504.1| (AL139077)
phosphoribosylamine--glycine ligase [Campylobacter
jejuni]
Length = 416
Score = 173 bits (434), Expect = 4e-42
Identities = 134/426 (31%), Positives = 216/426 (50%), Gaps = 29/426 (6%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M+++++G G RE++I AL R L N + + + D + +A+
Sbjct: 1 MKIMILGSGAREYSIALALRRVDKNLEFYFAPGNGATESLGTNLNLK---DPVVLATYAK 57
Query: 61 MWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRK 120
DL +G E+ L G+V+ +++G+ GP+K AA LET+K++ + F+++ I K
Sbjct: 58 EKGFDLCIVGSESFLAEGVVDIFKQQGLAIFGPSKAAAMLETSKSFMKSFLKKYRIKTAK 117
Query: 121 LFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKD- 179
+D+E+ K +I P+VVK GL GKGV + K +EEA E ++ +
Sbjct: 118 FLNT-NDIEKAKNFIYSLTPPIVVKADGLCAGKGVIIA----KTHEEAIEETAKMLSGES 172
Query: 180 ----GK-VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCS 234
GK V+IEE DG E + DG + + +P QD+ + D GP TGGMG+Y+ S
Sbjct: 173 FGDAGKLVVIEEFLDGYELSIFAVCDGNDFVLLPAAQDHKKLLDNDQGPNTGGMGAYAPS 232
Query: 235 NHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDP 294
+ + + K+ + T+ M+KEG + G+L+ M+ P ++E+N RFGDP
Sbjct: 233 SLANESLLR---KVQKDIILPTLAGMKKEGAEFCGVLFIGAMIVGNKPYVLEFNVRFGDP 289
Query: 295 EAINVLSILEDNLVEIAEGIVKGRVRGAKFQEKA--TVVKYLAPKGYPENPIRGAEIMVN 352
E ++ ++ED L E+ + R+R +K + K V A + YP +EI VN
Sbjct: 290 ECEVLMPLIEDPL-ELILAATQRRLRHSKIKIKKEFAVGVVCASENYPYKSSPKSEITVN 348
Query: 353 EEAIKEEGAKIVYASVD-ENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHV--RGPV 407
E + I YA V E+ KL+ G R L VG ++EEA+K A +V +G
Sbjct: 349 N---IPENSHISYAGVSLEDGKLMADGGRVLVCVGTGKSIEEAQKNAYKLCDNVNFKGKQ 405
Query: 408 FYRKDV 413
YRKD+
Sbjct: 406 -YRKDI 410
>gi|6321203 glycinamide ribotide synthetase and aminoimidazole ribotide
synthetase; Ade5,7p [Saccharomyces cerevisiae]
>gi|131619|sp|P07244|PUR2_YEAST BIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN ADE5,7 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORIBOSYL->
>gi|83383|pir||A26343 ADE5 multifunctional protein -
yeast (Saccharomyces cerevisiae)
>gi|3335|emb|CAA27867.1| (X04337) ADE5,7 gene product
(aa 1-802) GARSase (EC 6.3.4.13)/AIRSase [Saccharomyces
cerevisiae] >gi|1322895|emb|CAA96952.1| (Z72756) ORF
YGL234w [Saccharomyces cerevisiae]
Length = 802
Score = 168 bits (421), Expect = 1e-40
Identities = 127/444 (28%), Positives = 220/444 (48%), Gaps = 41/444 (9%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
+ +L++G G REH + LA+ + N G A + I+ + + V FAR
Sbjct: 2 LNILVLGNGAREHVLVTKLAQSPTVGKIYVAPGNGGTATMDPSRVINWDITPD-VANFAR 60
Query: 61 MWN------VDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERN 114
+ + ++L GPE PL GI + GIP GP+ +AA+LE +KA+++ FM ++
Sbjct: 61 LQSMAVEHKINLVVPGPELPLVNGITSVFHSVGIPVFGPSVKAAQLEASKAFSKRFMSKH 120
Query: 115 DIPGRKLFKVFDDVEEMKAWIDEY-GKPVVVKPLGLTGGKGVKVVG------YQLKDNEE 167
+IP + VF + EE +++ + K V+K G+ GKGV + +KD
Sbjct: 121 NIPTAS-YDVFTNPEEAISFLQAHTDKAFVIKADGIAAGKGVIIPSSIDESVQAIKDIMV 179
Query: 168 AKEYAEYLIKKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGG 227
K++ E K +V+IE+ +G E + DG + +P+ QD+ ++GD G TGG
Sbjct: 180 TKQFGEEAGK---QVVIEQFLEGDEISLLTIVDGYSHFNLPVAQDHKRIFDGDKGLNTGG 236
Query: 228 MGSYSCSNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREG------ 281
MG+Y+ + P + K + + ++ TI MR++G P+ G+L+ +L ++
Sbjct: 237 MGAYAPAPVATPSLLK---TIDSQIVKPTIDGMRRDGMPFVGVLFTGMILVKDSKTNQLV 293
Query: 282 PVIIEYNARFGDPEAINVLSILED--NLVEIAEGIVKGRVRGAKF---QEKATVVKYLAP 336
P ++EYN RFGDPE VLS+L+D +L ++ + R+ ++ V +A
Sbjct: 294 PEVLEYNVRFGDPETQAVLSLLDDQTDLAQVFLAAAEHRLDSVNIGIDDTRSAVTVVVAA 353
Query: 337 KGYPENPIRGAEIMVNEE------AIKEEGAKIVYASVDENMKLLGSRALAMVGVADTLE 390
GYPE+ +G +I ++ + I + G K Y S +++ G R L++ A L
Sbjct: 354 GGYPESYAKGDKITLDTDKLPPHTQIFQAGTK--YDSATDSLLTNGGRVLSVTSTAQDLR 411
Query: 391 EAEKIAEAGIRHVR-GPVFYRKDV 413
A ++ V +YRKD+
Sbjct: 412 TAVDTVYEAVKCVHFQNSYYRKDI 435
>pir||T07778 phosphoribosylamine--glycine ligase (EC 6.3.4.13) - soybean
(fragment) >gi|1321820|emb|CAA65607.1| (X96864)
phosphoribosylamine--glycine ligase [Glycine max]
Length = 392
Score = 162 bits (405), Expect = 9e-39
Identities = 121/367 (32%), Positives = 184/367 (49%), Gaps = 24/367 (6%)
Query: 35 PGLARISRDYGISKETDVE-----KVVRFARMWNVDLAFIGPEAPLEAGIVNALEREGIP 89
PG A I+ + +D+E V+ F R V L +GPEAPL AG+ N L + GIP
Sbjct: 13 PGNAPIASSGNATCISDLEVYDGAAVISFCRKMGVGLVVVGPEAPLVAGLTNELLKAGIP 72
Query: 90 TVGPTKEAARLETNKAWAREFMERNDIPGRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGL 149
T GP+ EAA LE +K + + ++ DIP K +K F D +I E G P+V+K GL
Sbjct: 73 TFGPSAEAAALEGSKNFMKHLCDKYDIPTAK-YKTFIDPSAANEYIQEQGAPIVIKADGL 131
Query: 150 TGGKGVKVVGYQLKDNEEAKEYA---EYLIKKDGKVLIEERTDGVEFTFQVFSDGRNVIP 206
GKGV V L++ EA + L+ + L+ + F + +
Sbjct: 132 AAGKGV-TVAMTLEEANEAVDQCWSRVILVLQVVVSLLRNFYKEKKHPFLHWLMEKMQFH 190
Query: 207 MPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPFITKEDWKMALRTLE-ETIKAMRKEGY 265
QD+ +GD GP TGGMG+YS + P ITKE + + ++ T+K M EG
Sbjct: 191 YNPAQDHKRVGDGDTGPNTGGMGAYSPA----PIITKELQSIVIHSIIIPTVKGMSAEGC 246
Query: 266 PYKGILYGQFMLSREG--PVIIEYNARFGDPEAINVLSILEDNLVEIAEGIVKGRVRG-- 321
+ G+LY M+ ++ P +IEYN RFGDPE ++ LE +LV++ +G + G
Sbjct: 247 KFVGVLYAGLMIEKKSGMPKLIEYNVRFGDPECQVLMVRLESDLVQVLLSACRGELSGLS 306
Query: 322 AKFQEKATVVKYLAPKGYPENPIRGAEIMVNEEA-IKEEGAKIVYA----SVDENMKLLG 376
+ + +V +A GYP + +G I +EA + G KI +A ++ EN+ LG
Sbjct: 307 LNWSPGSAMVVVMASNGYPGSYEKGTVIENLQEAELAAPGIKIFHAGTLLTLKENLLQLG 366
Query: 377 SRALAMV 383
L ++
Sbjct: 367 GVFLGLL 373
>pir||T16297 hypothetical protein F38B6.4 - Caenorhabditis elegans
>gi|1055176|gb|AAA81142.1| (U40060) coded for by C.
elegans cDNA yk45e7.3; coded for by C. elegans cDNA
yk45e7.5; similar to the multifunctional enzyme in
purine biosynthesis phosphoribosylamine-glycine
ligase/phosphoribosylformylglycinamidine
cyclo-ligase/phosphoribosylglycina>
Length = 946
Score = 150 bits (374), Expect = 4e-35
Identities = 124/426 (29%), Positives = 198/426 (46%), Gaps = 53/426 (12%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETDVEKVVRFAR 60
M VL+VG GGREHA+ + + V+ PG S I+ D++ V F
Sbjct: 1 MNVLIVGSGGREHALAWKMKQSPKVKNVIVA---PGNGGHSERIDINSN-DLDAVADFCE 56
Query: 61 MWNVDLAFIGPEAPLEAGIVNALER--EGIPTVGPTKEAARLETNKAWAREFMERNDIPG 118
N+ IGPE PL G+ + L R + GP K+ A+LET+K++++ FM+ +P
Sbjct: 57 KHNIHCVLIGPEEPLSNGLADHLIRIHPNLMVFGPLKDGAQLETSKSFSKHFMKEYGLPT 116
Query: 119 RKLFKV-FDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLI- 176
V ++V+ + + + GL GKGV + ++N EA E A ++
Sbjct: 117 ADFVTVSIENVKSLDCVFERFPAAD-----GLAAGKGVIIP----RNNAEAVEAARSILH 167
Query: 177 ----KKDGKVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYS 232
V+IEER +G E + F+DG + MPL +D+ E D+GP TG MG +
Sbjct: 168 GQFGNAGRTVIIEERLEGYEVSALAFTDGISFKRMPLGKDHKRLLESDLGPNTG-MGVVA 226
Query: 233 CSNHILPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFG 292
+ + KE + E+T+K + Y G+LY FM+ + P+++E+N RFG
Sbjct: 227 PVS-----VPKEVDRQIDEIFEKTLKGLADRKIKYCGVLYAGFMIVDQKPLLLEFNCRFG 281
Query: 293 DPEAINVLSILEDNLVEIAEGIVKGRVR--GAKFQEKATVVKYLAPKGYPENPIRGAEIM 350
DPE ++ +LE +L EI V + + K+ LA YP++ +G+ I
Sbjct: 282 DPETQVLMRLLESDLFEIISSCVNQTLNTCDINWSTKSVCGVVLASGNYPKSGDKGSPIT 341
Query: 351 VNEEAIKEEGAKIVYASVDENMKLLGSRALAMVGVADTLEEAEKIAEAGIRHVR--GPVF 408
V G R L + +ADTL +A + A ++++ G F
Sbjct: 342 VVTN---------------------GGRILCVTSLADTLHDAREHANKIAQNIQFTGKQF 380
Query: 409 YRKDVG 414
RKD+G
Sbjct: 381 -RKDIG 385
>emb|CAA52778.2| (X74766) glycinamide ribonucleotide synthetase [Arabidopsis
thaliana]
Length = 311
Score = 146 bits (365), Expect = 4e-34
Identities = 99/315 (31%), Positives = 159/315 (50%), Gaps = 25/315 (7%)
Query: 108 REFMERNDIPGRKLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEE 167
+ + +IP K +K F D K +I E G P+V+K GL GKGV V + EE
Sbjct: 2 KNLCHKYNIPTAK-YKTFSDASAAKEYIQEQGAPIVIKADGLAAGKGVTVA----MELEE 56
Query: 168 AKEYAEYLIKKDG------KVLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDV 221
A E + ++ K +V++EE +G E +F DG N IP+ QD+ +GD
Sbjct: 57 AFEAVDSMLVKGVFGSAGCQVVVEEFLEGEEASFFALVDGENAIPLESAQDHKRVGDGDT 116
Query: 222 GPITGGMGSYSCSNHILPFITKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSRE 280
GP TGGMG+YS + P +TKE + + + T+K M +EG + G+L+ M+ ++
Sbjct: 117 GPNTGGMGAYSPA----PVLTKELQDFVMESIIHPTVKGMAEEGCKFVGVLFAGLMIEKK 172
Query: 281 GPVI--IEYNARFGDPEAINVLSILEDNLVEIAEGIVKGRVRGAK--FQEKATVVKYLAP 336
+ IE+N RFGDPE ++ LE +L ++ KG + G + + + +V +A
Sbjct: 173 SGFLSFIEFNVRFGDPECQVLMMRLESDLAKVLLAACKGELSGVSLDWSKDSAMVVVMAS 232
Query: 337 KGYPENPIRGAEIMVNEEAIK-EEGAKIVYASV----DENMKLLGSRALAMVGVADTLEE 391
GYP + +G+ I EEA + G K+ +A + N+ G R L + LEE
Sbjct: 233 NGYPGSYEKGSIIKNLEEAERVAPGVKVFHAGTGLDSEGNVVATGGRVLGVTAKGKDLEE 292
Query: 392 AEKIAEAGIRHVRGP 406
A + A + ++ + P
Sbjct: 293 ARERAYSAVQQINWP 307
>emb|CAC11733.1| (AL445064) phosphoribosylamide-glycine ligase related protein
[Thermoplasma acidophilum]
Length = 205
Score = 141 bits (351), Expect = 2e-32
Identities = 78/196 (39%), Positives = 123/196 (61%), Gaps = 6/196 (3%)
Query: 238 LPFITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSREGPVIIEYNARFGDPEAI 297
+PFI+ + A L + I+AM E P+KGI+YGQFM + G +IE NARF DPE I
Sbjct: 1 MPFISDRAPEEAKHILVDIIRAMNSENTPFKGIMYGQFMDTPHGVKVIEINARFADPEGI 60
Query: 298 NVLSILEDNLVEIAEGIVKGRVRGAK-FQEKATVVKYLAPKGYPENPIRGAEIMVNEEAI 356
NVL++L+ + VE I G ++G K F+ KA+V+KY+ P GY +P G EI + ++AI
Sbjct: 61 NVLTLLKSDFVETLHQIYDGNLQGDKIFERKASVLKYIVPIGYGSDPKPG-EIEL-DKAI 118
Query: 357 KEEGAKIVYASVDENM---KLLGSRALAMVGVADTLEEAEKIAEAGIRHVRGPVFYRKDV 413
+ G ++YASV +M K SR+LA++ +++ EA ++ ++ + HV+G + R+D+
Sbjct: 119 FDSGVDVLYASVSGDMLRLKQSTSRSLAIIAKGNSIPEASELVDSSLAHVKGSYYVRRDI 178
Query: 414 GTKESIEKRIRTMKEL 429
G + I+ +IR K L
Sbjct: 179 GRSDFIQSKIRKAKAL 194
>sp|Q9ZK07|PUR2_HELPJ PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438049|pir||A71846 glycinamide
ribonucleotide synthetase - Helicobacter pylori (strain
J99) >gi|4155729|gb|AAD06709.1| (AE001541) GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE [Helicobacter pylori J99]
Length = 424
Score = 139 bits (348), Expect = 4e-32
Identities = 114/427 (26%), Positives = 207/427 (47%), Gaps = 32/427 (7%)
Query: 3 VLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETD-VEKVVRFARM 61
VL+VG GRE+A+ + L + + N G ++D G + E + E +V A
Sbjct: 9 VLIVGNKGREYALAQRLQQDERVNALYFCLGNGG----TQDLGENLECEHYEHIVELALK 64
Query: 62 WNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRKL 121
+ LA I E PL G+ LE+ GI G +KEAA+LE +K++ + F++ I
Sbjct: 65 KQIHLAIISEEEPLILGLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIKSASY 124
Query: 122 FKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDGK 181
F+ +D++E +I P+V+K L K +V +Q EEA + E +K+ +
Sbjct: 125 FET-NDLKEALNYIQNASFPLVIKAL----NKNTSIVHHQ----EEALKILEDALKQSNE 175
Query: 182 -VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
V+IE +G E + + I +P Q+Y EGD G TGGMG+ + +N F
Sbjct: 176 PVIIEPFLEGFELSVTALIANDDFILLPFCQNYKRLLEGDNGVNTGGMGAIAPANF---F 232
Query: 241 ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSRE----GPVIIEYNARFGDPEA 296
+ + K+ + T++ ++ + P+KG+L + ++ E P +++++ RF D E
Sbjct: 233 SNELEEKIKNHIFKPTLEKLQADNTPFKGVLLAEIVIIEEKGVLEPYLLDFSVRFKDIEC 292
Query: 297 INVLSILEDNLVEIAEGIVKGRVRGAK--FQEKATVVKYLAPKGYPENPIRGAEIMVNEE 354
+L ++E+ L+++ KG + + F ++ + L + YP + + + +
Sbjct: 293 QTILPLVENPLLDLFLATAKGELHSLELVFSKEFVMSVALVSRNYPTSSSPKQTLYI--D 350
Query: 355 AIKEEGAKIVYASVDEN---MKLLGSRALAMVGVADTLEEAEKIAE--AGIRHVRGPVFY 409
+ E+ ++ V+++ + G R + +G +L EA A A H G +FY
Sbjct: 351 PVDEKKGHLILGEVEQDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQKVHFEG-MFY 409
Query: 410 RKDVGTK 416
RKD+G K
Sbjct: 410 RKDIGFK 416
>sp|P52421|PUR2_VIGUN PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438047|pir||T11532
phosphoribosylamine--glycine ligase (EC 6.3.4.13) -
cowpea (fragment) >gi|945062|gb|AAA74447.1| (U30896)
glycinamide ribonucleotide (GAR) synthetase [Vigna
unguiculata]
Length = 311
Score = 139 bits (347), Expect = 6e-32
Identities = 100/295 (33%), Positives = 149/295 (49%), Gaps = 22/295 (7%)
Query: 127 DVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDG-----K 181
D K +I E G P+V+K GL GKGV V + E K L++ D +
Sbjct: 1 DPRVRKQYIQEQGAPIVIKADGLAAGKGVTVA---MTLEEAYKAVDSMLVQGDFGSAGCR 57
Query: 182 VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPFI 241
V++EE +G E +F DG N IP+ QD+ +GD GP TGGMG+YS + P +
Sbjct: 58 VIVEEFLEGEEASFFALVDGENAIPLESAQDHKRVGDGDTGPNTGGMGAYSPA----PVL 113
Query: 242 TKEDWKMALRT-LEETIKAMRKEGYPYKGILYGQFMLSREG--PVIIEYNARFGDPEAIN 298
TKE + + + + T+K M EG + G+LY M+ ++ P +IEYN RFGDPE
Sbjct: 114 TKELQSIVMDSIIIPTVKGMSAEGSKFVGVLYAGLMIEKKSGMPKLIEYNVRFGDPECQV 173
Query: 299 VLSILEDNLVEIAEGIVKGRVRGA--KFQEKATVVKYLAPKGYPENPIRGAEIMVNEEA- 355
++ LE +LV++ +G + G K+ + +V +A KGYP + +G I EEA
Sbjct: 174 LMVRLESDLVQVLLAACRGELNGVSLKWSPGSAMVVVMASKGYPGSYQKGTVIENLEEAE 233
Query: 356 IKEEGAKIVYA--SVDENMKLL--GSRALAMVGVADTLEEAEKIAEAGIRHVRGP 406
G KI +A + D + + G R L + + LEEA A + +V P
Sbjct: 234 AVAPGIKIFHAGTAFDSEGRFIATGGRVLGVTAKGNDLEEACDRAYLAVENVNWP 288
>sp|O25817|PUR2_HELPY PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|7438048|pir||B64672 glycinamide
ribonucleotide synthetase - Helicobacter pylori (strain
26695) >gi|2314378|gb|AAD08261.1| (AE000627) glycinamide
ribonucleotide synthetase (purD) [Helicobacter pylori
26695]
Length = 424
Score = 137 bits (341), Expect = 3e-31
Identities = 115/427 (26%), Positives = 206/427 (47%), Gaps = 32/427 (7%)
Query: 3 VLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGISKETD-VEKVVRFARM 61
VL+VG GRE+A+ + L + + N G ++D G + E + E +V A
Sbjct: 9 VLIVGNKGREYALAQRLQQDERVNALYFCLGNGG----TQDLGENLECEHYEHIVELALK 64
Query: 62 WNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGRKL 121
+ LA I E L G+ LE+ GI G +KEAA+LE +K++ + F++ I
Sbjct: 65 KQIHLAIISEEEFLVLGLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIKSASY 124
Query: 122 FKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGVKVVGYQLKDNEEAKEYAEYLIKKDGK 181
F+ +D++E ++I P+V+K L K +V YQ EEA + E K+ +
Sbjct: 125 FET-NDLKEALSYIQNASFPLVIKAL----NKNTSIV-YQ---EEEAIKILEDAFKQSNE 175
Query: 182 -VLIEERTDGVEFTFQVFSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPF 240
V+IE +G E + + I +P Q+Y EGD G TGGMG+ + +N F
Sbjct: 176 PVIIEPFLEGFELSVTALIANDDFILLPFCQNYKRLLEGDNGVNTGGMGAIAPANF---F 232
Query: 241 ITKEDWKMALRTLEETIKAMRKEGYPYKGILYGQFMLSRE----GPVIIEYNARFGDPEA 296
+ + K+ + T++ ++ + P+KG+L + ++ E P +++++ RF D E
Sbjct: 233 SNELEEKIKNHIFKPTLEKLQADNTPFKGVLLAEIVIIEEKGVLEPYLLDFSVRFKDIEC 292
Query: 297 INVLSILEDNLVEIAEGIVKGRVRGAK--FQEKATVVKYLAPKGYPENPIRGAEIMVNEE 354
+L +LE +L+++ KG + + F ++ + L + YP + + + +
Sbjct: 293 QTILPLLESSLLDLCLATAKGELHSLELVFSKEFVMSVALVSRNYPTSSSPKQTLYI--D 350
Query: 355 AIKEEGAKIVYASVDEN---MKLLGSRALAMVGVADTLEEAEKIAE--AGIRHVRGPVFY 409
+ E+ ++ V+++ + G R + +G +L EA A A H G +FY
Sbjct: 351 PVDEKKGHLILGEVEQDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQKVHFEG-MFY 409
Query: 410 RKDVGTK 416
RKD+G K
Sbjct: 410 RKDIGFK 416
>sp|Q46482|PUR2_CHRVI PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE) >gi|1246215|gb|AAB02980.1| (L76417)
phosphoribosylamine-glycine ligase [Allochromatium
vinosum]
Length = 189
Score = 104 bits (257), Expect = 2e-21
Identities = 60/156 (38%), Positives = 89/156 (56%), Gaps = 2/156 (1%)
Query: 1 MRVLLVGGGGREHAIGEALARGGAELYVVSKHKNPGLARISRDYGIS-KETDVEKVVRFA 59
M++L+VG GGREHA+ A+ V N G A ++ D+ +V FA
Sbjct: 1 MKILIVGSGGREHALAWKAAQSPQVEQVFVAPGNGGTASEPGVENVAIAADDIAGLVEFA 60
Query: 60 RMWNVDLAFIGPEAPLEAGIVNALEREGIPTVGPTKEAARLETNKAWAREFMERNDIPGR 119
R ++ L +GPEAPL G+V+A G+P GP +A+LE +KA+A++F+ R+ IP
Sbjct: 61 RRESIGLTIVGPEAPLVLGLVDAFAEAGLPCFGPASGSAQLEGSKAFAKDFLHRHGIP-T 119
Query: 120 KLFKVFDDVEEMKAWIDEYGKPVVVKPLGLTGGKGV 155
+ VF ++E A++ + G PVVVK GL GKGV
Sbjct: 120 AAYGVFTELEPALAYLRQVGAPVVVKADGLAAGKGV 155
>pir||S54423 phosphoribosylamine--glycine ligase (EC 6.3.4.13) - Listeria
monocytogenes (fragment) >gi|476162|gb|AAA56675.1|
(U08866) 5'-phosphoribosyl-glycinamide synthetase
[Listeria monocytogenes]
Length = 90
Score = 76.9 bits (186), Expect = 4e-13
Identities = 40/90 (44%), Positives = 54/90 (59%), Gaps = 3/90 (3%)
Query: 198 FSDGRNVIPMPLVQDYPHAYEGDVGPITGGMGSYSCSNHILPFITKEDWKMALRTLEETI 257
F +G V PM + QD+ AYEGD GP TGGMG+YS HI + +E + L T
Sbjct: 4 FVNGEEVYPMSIAQDHKRAYEGDKGPNTGGMGAYSPVPHISEAVIEE---AVQKILLPTA 60
Query: 258 KAMRKEGYPYKGILYGQFMLSREGPVIIEY 287
K M KEG ++GILY +L+ +GP +IE+
Sbjct: 61 KGMVKEGRYFRGILYAGLILTADGPKVIEF 90
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.316 0.138 0.396
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 169042941
Number of Sequences: 2977
Number of extensions: 7611220
Number of successful extensions: 19856
Number of sequences better than 1.0e-10: 64
Number of HSP's better than 0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 19557
Number of HSP's gapped (non-prelim): 66
length of query: 438
length of database: 189,106,746
effective HSP length: 57
effective length of query: 381
effective length of database: 154,992,987
effective search space: 59052328047
effective search space used: 59052328047
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 166 (69.1 bits)