BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1299 (galE-2) DE:UDP-glucose 4-epimerase (galE-2)
(317 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||A75008 udp-glucose 4-epimerase (gale-2) PAB1299 - Pyrococcu... 639 0.0
pir||H71145 probable UDP-glucose 4-epimerase - Pyrococcus horiko... 533 e-151
gi|11497973 UDP-glucose 4-epimerase (galE-1) [Archaeoglobus fulg... 330 1e-89
emb|CAC11160.1| (AL445063) UDP-glucose 4-epimerase related prote... 282 5e-75
gb|AAK40511.1| UDP-glucose 4-epimerase (galE-2) [Sulfolobus solf... 273 2e-72
gb|AAG19227.1| (AE005019) UDP-glucose 4-epimerase; GalE1 [Haloba... 255 6e-67
pir||S44960 lmbM protein - Streptomyces lincolnensis >gi|487703|... 210 1e-53
pir||S69807 lmbM protein - Streptomyces lincolnensis 199 3e-50
sp|Q57664|GALE_METJA PUTATIVE UDP-GLUCOSE 4-EPIMERASE (GALACTOWA... 180 3e-44
pir||C72368 hypothetical protein TM0509 - Thermotoga maritima (s... 164 9e-40
pir||D75143 udp-glucose 4-epimerase (gale-1) PAB2145 - Pyrococcu... 163 2e-39
dbj|BAB07368.1| (AP001519) UDP-glucose 4-epimerase [Bacillus hal... 159 4e-38
pir||A71183 probable UDP-glucose 4-epimerase - Pyrococcus horiko... 157 2e-37
gb|AAK41108.1| UDP-glucose 4-epimerase (galE-2) [Sulfolobus solf... 150 3e-35
emb|CAB57495.1| (Y18930) dTDP-glucose 4,6-dehydratase [Sulfolobu... 150 3e-35
pir||D70696 probable dtdp-glucose 4 - Mycobacterium tuberculosis... 146 2e-34
pir||C83136 probable epimerase PA4068 [imported] - Pseudomonas a... 146 3e-34
dbj|BAB09774.1| (AB016890) dTDP-glucose 4-6-dehydratase [Arabido... 146 4e-34
pir||T45701 dTDP-glucose 4-6-dehydratases-like protein - Arabido... 144 1e-33
dbj|BAB07098.1| (AP001518) UDP-glucose 4-epimerase [Bacillus hal... 143 2e-33
pir||T00419 dTDP-glucose 4-6-dehydratase homolog T30B22.4 - Arab... 141 8e-33
pir||S58282 dTDP-glucose 4-6-dehydratase homolog D18 - Arabidops... 140 2e-32
pir||T48072 dTDP-glucose 4-6-dehydratase homolog D18 - Arabidops... 140 2e-32
gb|AAF50474.1| (AE003556) CG7979 gene product [Drosophila melano... 140 2e-32
gb|AAC79582.1| (AC005727) putative nucleotide-sugar dehydratase ... 140 2e-32
gi|11497937 dTDP-glucose 4,6-dehydratase (rfbB) [Archaeoglobus f... 139 5e-32
gb|AAG18701.1| (AE004975) UDP-glucose 4-epimerase; GalE2 [Haloba... 138 7e-32
pir||T45892 dTDP-glucose 4-6-dehydratase-like protein - Arabidop... 138 9e-32
pir||S75550 dTDP-glucose 4-6-dehydratase - Synechocystis sp. (st... 136 3e-31
gb|AAD12951.1| (AF078135) unknown [Leptospira borgpetersenii] 136 4e-31
pir||T51252 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [imported]... 136 4e-31
pir||C70562 probable DTDP-Glucose 4 - Mycobacterium tuberculosis... 135 6e-31
emb|CAC14890.1| (AJ295156) d-TDP-glucose dehydratase [Phragmites... 134 1e-30
gb|AAD52168.1|AF144879_7 (AF144879) unknown [Leptospira interrog... 133 3e-30
pir||H69105 dTDP-glucose 4,6-dehydratase - Methanobacterium ther... 132 4e-30
sp|Q58455|YA55_METJA HYPOTHETICAL PROTEIN MJ1055 >gi|2127791|pir... 131 1e-29
gb|AAA68211.1| (L37354) thymidine diphosphoglucose 4,6-dehydrata... 130 2e-29
gb|AAF25549.1|AF109295_4 (AF109295) GalE [Staphylococcus carnosus] 129 4e-29
pir||C69149 conserved hypothetical protein MTH380 - Methanobacte... 129 4e-29
pir||D81275 probable nucleotide sugar dehydratase Cj1319 [import... 129 4e-29
gb|AAB84886.1| (AE000823) UDP-glucose 4-epimerase homolog [Metha... 129 4e-29
gi|7657641 dTDP-D-glucose 4,6-dehydratase [Homo sapiens] >gi|412... 129 6e-29
pir||T15892 hypothetical protein D2096.4 - Caenorhabditis elegan... 128 1e-28
pir||G70415 nucleotide sugar epimerase - Aquifex aeolicus >gi|29... 128 1e-28
pir||S75089 UDP-glucose 4-epimerase - Synechocystis sp. (strain ... 127 2e-28
pir||G71151 probable dTDP-glucose 4,6-dehydratase - Pyrococcus h... 127 2e-28
sp|Q9KDV3|GALE_BACHD UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 127 2e-28
dbj|BAB07428.1| (AP001519) nucleotide sugar epimerase (biosynthe... 127 2e-28
pir||B75098 dtdp-glucose 4,6-dehydratase (rfbb) PAB0785 - Pyroco... 125 7e-28
emb|CAA18814.1| (AL023093) putative sugar dehyratase [Mycobacter... 125 9e-28
pir||H69988 NDP-sugar epimerase homolog ytcB - Bacillus subtilis... 125 9e-28
sp|P33119|GALE_CORDI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 124 1e-27
pir||T35486 probable nucleotide-sugar dehydratase - Streptomyces... 123 2e-27
pir||A69184 UDP-glucose 4-epimerase - Methanobacterium thermoaut... 123 3e-27
sp|Q45291|GALE_BRELA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 122 4e-27
gb|AAG18457.1|AF306787_1 (AF306787) AprE [Streptomyces tenebrarius] 122 4e-27
pir||D75486 probable UDP-glucose 4-epimerase - Deinococcus radio... 122 7e-27
gb|AAD50491.1|AF172324_9 (AF172324) UDP-Glc-4-epimerase GalE [Es... 121 1e-26
emb|CAB95930.1| (AL359989) UDP-glucose 4-epimerase [Streptomyces... 120 2e-26
dbj|BAB07083.1| (AP001518) spore coat polysaccharide synthesis (... 120 3e-26
gb|AAC68681.1| (AF079762) TDP-glucose-4,6-dehydratase [Streptomy... 119 4e-26
gb|AAD13546.1| (AF080235) NDP-hexose 4,6-dehydratase homolog [St... 119 4e-26
gb|AAC18831.1| (AF059755) nucleotide sugar epimerase [Vibrio vul... 119 5e-26
sp|P09609|GALX_KLULA GAL10 BIFUNCTIONAL PROTEIN [INCLUDES: UDP-G... 119 5e-26
emb|CAA71250.1| (Y10168) glucose epimerase [Bacillus thuringiensis] 118 6e-26
sp|P40801|GALX_PACTA GAL10 BIFUNCTIONAL PROTEIN [INCLUDES: UDP-G... 118 6e-26
dbj|BAA84593.1| (AB032523) dTDP-glucose 4,6-dehydratase [Strepto... 118 8e-26
pir||A75303 UDP-glucose 4-epimerase - Deinococcus radiodurans (s... 118 1e-25
pir||F81317 UDPglucose 4-epimerase (EC 5.1.3.2) Cj1131c [importe... 117 2e-25
gb|AAG18703.1| (AE004975) GDP-D-mannose dehydratase; Gmd [Haloba... 117 2e-25
pir||A70392 UDP-glucose-4-epimerase - Aquifex aeolicus >gi|29835... 116 2e-25
emb|CAA72350.1| (Y11648) galE [Campylobacter jejuni] 116 2e-25
emb|CAC01389.1| (AJ131360) UDP-glucose 4-epimease [Campylobacter... 116 2e-25
gb|AAB48319.1| (U29691) CDP-tyvelose epimerase [Yersinia pseudot... 116 3e-25
pir||C75597 thymidine diphosphoglucose 4,6-dehydratase - Deinoco... 115 7e-25
sp|P21977|GALE_STRTR UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 114 2e-24
sp|P39630|SPSJ_BACSU SPORE COAT POLYSACCHARIDE BIOSYNTHESIS PROT... 114 2e-24
sp|P39858|CAPI_STAAU CAPI PROTEIN >gi|506705|gb|AAA64648.1| (U10... 113 2e-24
gi|6319493 UDP-glucose 4-epimerase; Gal10p [Saccharomyces cerevi... 113 2e-24
pir||T48867 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated... 113 2e-24
pir||C81288 probable sugar-nucleotide epimerase/dehydratease Cj1... 113 2e-24
pir||G82785 dTDP-glucose 4-6-dehydratase XF0611 [imported] - Xyl... 113 3e-24
gb|AAG02361.1|AF210249_20 (AF210249) sugar epimerase BlmG [Strep... 113 3e-24
sp|P96995|GALE_STRMU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 113 4e-24
gb|AAF00211.1|AF164960_7 (AF164960) dNDP-glucose 4,6-dehydratase... 113 4e-24
pir||G83471 UDP-glucose 4-epimerase PA1384 [imported] - Pseudomo... 113 4e-24
sp|P09147|GALE_ECOLI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 112 5e-24
gb|AAK41125.1| dTDP-Glucose 4,6-dehydratase (rfbB-1) [Sulfolobus... 112 5e-24
gb|AAK41973.1| dTDP-Glucose 4,6-dehydratase (rfbB-3) [Sulfolobus... 112 5e-24
sp|P13226|GALE_STRLI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 112 5e-24
pir||S70889 nucleotide sugar epimerase homolog - Vibrio cholerae... 112 5e-24
pir||T44339 hypothetical protein wbfW [imported] - Vibrio choler... 112 5e-24
emb|CAB57474.1| (Y18930) dTDP-glucose 4,6-dehydratase (rfbB) [Su... 112 5e-24
pdb|1UDB| Structure Of Udp-Galactose-4-Epimerase Complexed Wit... 112 6e-24
sp|Q56093|GALE_SALTI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 111 8e-24
pir||B69815 CDP-glucose 4,6-dehydratase homolog yfnG - Bacillus ... 111 8e-24
pdb|1KVR| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 111 1e-23
gb|AAF36926.1|AF221951_2 (AF221951) putative UDP-galactose 4-epi... 111 1e-23
gb|AAG26471.1|AF285774_11 (AF285774) putative UDP-glucuronic aci... 111 1e-23
pdb|1KVS| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 111 1e-23
pdb|1KVU| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 111 1e-23
pdb|1KVQ| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 111 1e-23
pir||H72588 probable dTDP-glucose 4,6-dehydratase APE1180 - Aero... 110 2e-23
pir||S49054 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [similarit... 110 2e-23
gb|AAF82605.1| (AF144042) dTDP-glucose 4,6-dehydratase [Streptom... 110 2e-23
sp|Q59678|GALE_PASHA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 109 3e-23
gb|AAD30579.1|AC007260_10 (AC007260) Similar to dTDP-D-glucose 4... 109 3e-23
pdb|1KVT| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 109 3e-23
pdb|1A9Y| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXE... 109 3e-23
sp|P14169|RFBE_SALTI CDP-TYVELOSE-2-EPIMERASE >gi|861175|gb|AAB4... 109 4e-23
pdb|1A9Z| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXE... 109 4e-23
sp|P55180|GALE_BACSU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 109 6e-23
gb|AAD50494.1|AF172324_12 (AF172324) WbnF [Escherichia coli] 108 9e-23
gb|AAC78676.1| (AF094575) dTDP-glucose-4,6-dehydratase Cps19aN [... 108 1e-22
pir||B33604 rfbE protein - Salmonella sp 107 2e-22
sp|P35673|GALE_ERWAM UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 107 2e-22
pir||T44844 UDPglucose 4-epimerase (EC 5.1.3.2) [imported] - Aci... 107 2e-22
emb|CAB05928.1| (Z83335) unknown [Streptococcus pneumoniae] 106 4e-22
emb|CAB05932.1| (Z83335) dTDP-glucose 4,6-dehydratase [Streptoco... 106 4e-22
pir||T44521 polysaccharide biosynthetic protein [imported] - Shi... 106 4e-22
gb|AAF78439.1|AC018748_18 (AC018748) Contains similarity to dTPD... 106 4e-22
gb|AAF78483.1|AC012187_3 (AC012187) Strong similarity to UDPgluc... 106 4e-22
dbj|BAB06023.1| (AP001515) nucleotide sugar epimerase (capsular ... 106 4e-22
gb|AAC46054.1| (U78089) UDP-glucose epimerase [Brucella abortus] 106 5e-22
pir||T01881 UDPglucose 4-epimerase (EC 5.1.3.2) F8M12.10 - Arabi... 106 5e-22
pir||T04291 probable UDPglucose 4-epimerase (EC 5.1.3.2) - Arabi... 106 5e-22
sp|P22715|GALE_SALTY UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 106 5e-22
gb|AAG12659.1|AC010795_3 (AC010795) uridine diphosphate glucose ... 105 6e-22
gb|AAA57872.1| (U09349) UDP-glucose 4-epimerase [Azospirillum br... 105 8e-22
gb|AAC38674.1| (AF030359) dTDP-glucose-4,6-dehydratase [Streptoc... 105 8e-22
gb|AAC38679.1| (AF030360) dTDP-glucose-4,6-dehydratase [Streptoc... 105 8e-22
gb|AAD19915.1| (AF105113) dTDP-glucose-4,6-dehydratase [Streptoc... 105 8e-22
emb|CAB44218.1| (AJ011653) UDP-galactose 4-epimerase [Lactococcu... 105 8e-22
sp|Q43070|GAE1_PEA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (U... 104 1e-21
gb|AAC44971.1| (U09239) dTDP-glucose-4,6-dehydratase [Streptococ... 104 1e-21
pir||T51106 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated... 104 1e-21
emb|CAB61555.1| (AL133171) putative dehydratase [Streptomyces co... 104 1e-21
sp|O65780|GAE1_CYATE UDP-GLUCOSE 4-EPIMERASE GEPI42 (GALACTOWALD... 104 2e-21
sp|O84903|GALE_LACCA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 104 2e-21
emb|CAA77209.1| (Y18523) dTDP-glucose 4,6-dehydratase [Actinopla... 104 2e-21
gb|AAF59935.1| (AF237895) dTDP-D-glucose 4,6-dehydratase [Strept... 104 2e-21
sp|P95780|RMLB_STRMU DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1813347|db... 103 2e-21
gb|AAC63021.1| (AF082008) UDP-galactose-4-epimerase [Lactococcus... 103 2e-21
gb|AAD11505.1| (U60828) UDP-galactose-4-epimerase [Lactococcus l... 103 2e-21
pir||F82576 nucleotide sugar epimerase XF2279 [imported] - Xylel... 103 3e-21
sp|Q05026|GALE_NEIGO UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 102 5e-21
pir||S62783 UDPglucose 4-epimerase (EC 5.1.3.2) - Arabidopsis th... 102 5e-21
gb|AAD31800.1|AF128273_3 (AF128273) TDP-glucose-4,6-dehydratase ... 102 5e-21
pir||T48135 nucleotide sugar epimerase-like protein - Arabidopsi... 102 5e-21
pir||F82419 UDP-glucose 4-epimerase VCA0774 [imported] - Vibrio ... 102 7e-21
pir||S70744 UDPglucose 4-epimerase (EC 5.1.3.2) - Yersinia enter... 101 9e-21
pir||T46572 probable UDP-glucuronic acid epimerase (EC 5.1.3.-) ... 101 9e-21
gb|AAG21514.1|AC066689_8 (AC066689) UDP-galactose 4-epimerase, p... 101 9e-21
gb|AAD45555.1|U70376_20 (U70376) SpcJ [Streptomyces flavopersicus] 101 1e-20
sp|O54067|LPSL_RHIME UDP-GLUCURONATE 5'-EPIMERASE (UDP-GLUCURONI... 101 1e-20
sp|Q9T0A7|GAE3_ARATH PROBABLE UDP-GLUCOSE 4-EPIMERASE (GALACTOWA... 101 2e-20
emb|CAA40568.1| (X57315) UDP-galactose-4-epimerase [Haemophilus ... 100 2e-20
sp|P24325|GALE_HAEIN UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 100 2e-20
gb|AAF67513.1|AF170880_20 (AF170880) NovT [Streptomyces spheroides] 100 2e-20
pir||S75783 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Synechoc... 100 3e-20
pir||S74768 UDPglucose 4-epimerase (EC 5.1.3.2) - Synechocystis ... 100 3e-20
emb|CAB79762.1| (AL161577) nucleotide sugar epimerase-like prote... 100 3e-20
pir||H64564 UDP-glucose 4-epimerase - Helicobacter pylori (strai... 100 4e-20
pir||G71858 udp-glucose 4-epimerase - Helicobacter pylori (strai... 100 4e-20
gb|AAF76478.1|AC020622_12 (AC020622) Contains similarity to CAPI... 100 4e-20
gb|AAB82632.1| (AC002387) putative nucleotide sugar epimerase [A... 99 5e-20
gb|AAF01814.1|AF187532_10 (AF187532) putative dTDP-glucose-4,6-d... 99 5e-20
gb|AAC35922.1| (AF071085) putative dTDP-glucose-4,6-dehydratase ... 99 8e-20
gb|AAD12971.1| (AF078135) RmlB [Leptospira borgpetersenii] 99 8e-20
pir||T01339 hypothetical protein F6N15.16 - Arabidopsis thaliana... 98 1e-19
gb|AAB47842.1| (U61226) RfbB [Leptospira interrogans] >gi|581432... 98 1e-19
gb|AAD31797.1|AF128272_2 (AF128272) TDP-glucose-4,6-dehydratase ... 98 1e-19
sp|Q59745|EXOB_RHILT UDP-GLUCOSE 4-EPIMERASE (UDP-GALACTOSE 4-EP... 97 2e-19
dbj|BAB03000.1| (AP001297) nucleotide sugar epimerase-like prote... 97 2e-19
sp|Q04973|VIPB_SALTI VI POLYSACCHARIDE BIOSYNTHESIS PROTEIN VIPB... 97 3e-19
emb|CAB65206.1| (AJ007311) RmlB protein [Legionella pneumophila] 97 3e-19
pir||S76937 hypothetical protein - Synechocystis sp. (strain PCC... 96 4e-19
sp|O65781|GAE2_CYATE UDP-GLUCOSE 4-EPIMERASE GEPI48 (GALACTOWALD... 95 9e-19
pir||E69148 UDP-glucose 4-epimerase related protein - Methanobac... 95 1e-18
gb|AAG09513.1|AF279619_1 (AF279619) dTDP-D-glucose-4,6-dehydrata... 95 1e-18
sp|Q59083|EXOB_AZOBR UDP-GLUCOSE 4-EPIMERASE (UDP-GALACTOSE 4-EP... 94 2e-18
sp|P55462|RFBB_RHISN PROBABLE DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|2... 94 3e-18
pir||T15370 hypothetical protein C01F1.3 - Caenorhabditis elegan... 93 4e-18
gb|AAC70775.1| (AF097519) dTDP-D-glucose 4,6 dehydratase [Klebsi... 93 4e-18
pir||B83000 dTDP-D-glucose 4,6-dehydratase PA5161 [imported] - P... 93 5e-18
emb|CAB01951.1| (Z79692) ExpA9 [Sinorhizobium meliloti] 92 8e-18
dbj|BAA19633.1| (AB002668) dTDP-D-glucose-4,6-dehydratase [Actin... 92 8e-18
gb|AAF33465.1| (AF233324) 89% identity with E. coli dTDP-D-gluco... 92 8e-18
pir||S74751 CDP-glucose 4,6-dehydratase - Synechocystis sp. (str... 92 1e-17
pir||T00102 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Actinoba... 92 1e-17
dbj|BAA82532.1| (AB030032) dTDP-D-glucose 4,6-dehydratase [Actin... 91 1e-17
gb|AAF73454.1|AF264025_5 (AF264025) putative dTDP-glucose 4, 6-d... 91 2e-17
gb|AAG09522.1|AF279621_1 (AF279621) dTDP-D-glucose-4,6-dehydrata... 91 2e-17
sp|P37777|RFBB_SHIFL DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1073703|pi... 90 2e-17
gb|AAG09534.1|AF279624_1 (AF279624) dTDP-D-glucose-4,6-dehydrata... 90 2e-17
dbj|BAA94402.1| (AB041266) dTDP-D-glucose 4,6-dehydratase [Actin... 90 3e-17
sp|P55293|RBB2_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437235|pi... 90 4e-17
sp|P29782|STRE_STRGR DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|68393|pir|... 89 5e-17
emb|CAB92213.1| (AL356592) NAD-dependent dehydratase. [Streptomy... 88 1e-16
gb|AAG09506.1|AF279617_1 (AF279617) dTDP-D-glucose-4,6-dehydrata... 88 1e-16
gb|AAG09530.1|AF279623_1 (AF279623) dTDP-D-glucose-4,6-dehydrata... 88 1e-16
sp|P37759|RBB1_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437240|pi... 87 2e-16
sp|P26391|RFBB_SALTY DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|96840|pir|... 87 3e-16
pir||I55054 dTDP-D-glucose 4,6-dehydratase - Escherichia coli 87 3e-16
emb|CAB76986.1| (AL159178) putative epimerase [Streptomyces coel... 87 3e-16
gb|AAG09509.1|AF279618_1 (AF279618) dTDP-D-glucose-4,6-dehydrata... 87 3e-16
sp|P44914|RFFG_HAEIN DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1075419|pi... 84 2e-15
gb|AAC37049.1| (L09189) dTDP-D-glucose 4,6-dehydratase [Neisseri... 82 7e-15
pir||G82014 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMA0204 [i... 81 2e-14
sp|P26397|RFBG_SALTY CDP-GLUCOSE 4,6-DEHYDRATASE >gi|96842|pir||... 80 3e-14
pir||G81242 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMB0063, N... 80 3e-14
sp|P55294|RFBB_NEIMB DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437244|pi... 79 6e-14
gi|9631863 similar to Mycobacterium ORF, corresponds to GenBank ... 79 8e-14
sp|P37761|RFBB_NEIGO DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|628590|pir... 78 2e-13
gb|AAC60774.1| (U46859) Fcl [Yersinia enterocolitica (type 0:8)] 75 2e-12
gb|AAD05454.1| (AF064070) putative dTDP-D-glucose 4,6-dehydratas... 75 2e-12
sp|O52325|YFBG_SALTY HYPOTHETICAL 73.6 KDA PROTEIN IN AIS-PMRD I... 74 2e-12
pir||G69142 GDP-D-mannose dehydratase - Methanobacterium thermoa... 72 8e-12
gb|AAD46729.1|AF078736_3 (AF078736) GDP-D-mannose dehydratase [E... 69 5e-11
>pir||A75008 udp-glucose 4-epimerase (gale-2) PAB1299 - Pyrococcus abyssi
(strain Orsay) >gi|5459017|emb|CAB50503.1| (AJ248288)
UDP-glucose 4-epimerase (galE-2) [Pyrococcus abyssi]
Length = 317
Score = 639 bits (1630), Expect = 0.0
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY
Sbjct: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS
Sbjct: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS
Sbjct: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
Query: 181 NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNL 240
NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNL
Sbjct: 181 NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNL 240
Query: 241 GNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKM 300
GNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKM
Sbjct: 241 GNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKM 300
Query: 301 NSYEAVRRTVRELLGVL 317
NSYEAVRRTVRELLGVL
Sbjct: 301 NSYEAVRRTVRELLGVL 317
>pir||H71145 probable UDP-glucose 4-epimerase - Pyrococcus horikoshii
>gi|3256770|dbj|BAA29453.1| (AP000002) 318aa long
hypothetical UDP-glucose 4-epimerase [Pyrococcus
horikoshii]
Length = 318
Score = 533 bits (1359), Expect = e-151
Identities = 259/314 (82%), Positives = 284/314 (89%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M+VLVTGGAGFIGSHLVDRLME+GY+VRVLDDLSAGSL+N+ WL NENFEFI+GDMRD
Sbjct: 1 MRVLVTGGAGFIGSHLVDRLMEEGYKVRVLDDLSAGSLKNIEGWLGNENFEFIKGDMRDV 60
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+IV +AV DV+ VFHLAANPEVRI SQSPELLYETNVLITYNLL A+R S VK+LVFTSS
Sbjct: 61 EIVSKAVKDVDAVFHLAANPEVRIGSQSPELLYETNVLITYNLLNAVRNSGVKYLVFTSS 120
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
STVYGDA V+PTPE Y PLEPISVYG AKLAAEALISGYAH F FRALI RLANIIGKRS
Sbjct: 121 STVYGDAKVIPTPEDYAPLEPISVYGAAKLAAEALISGYAHTFDFRALIIRLANIIGKRS 180
Query: 181 NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNL 240
NHGVIYDFINKLK NPNELEILGDG QRKSYLH+SDTI+GI+ +FE+F + D YNL
Sbjct: 181 NHGVIYDFINKLKANPNELEILGDGTQRKSYLHISDTIDGIMKLFEHFLNGEERVDFYNL 240
Query: 241 GNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKM 300
GNEDWITVKEIAEIVSEEM L+P+FKFTGGVDGGRGWKGDVK MLLSIEKAK+TGW+P+M
Sbjct: 241 GNEDWITVKEIAEIVSEEMNLNPRFKFTGGVDGGRGWKGDVKLMLLSIEKAKRTGWKPRM 300
Query: 301 NSYEAVRRTVRELL 314
NSYEAVR+TVRE+L
Sbjct: 301 NSYEAVRKTVREML 314
>gi|11497973 UDP-glucose 4-epimerase (galE-1) [Archaeoglobus fulgidus]
>gi|7437251|pir||A69295 UDP-glucose 4-epimerase (galE-1)
homolog - Archaeoglobus fulgidus
>gi|2650268|gb|AAB90870.1| (AE001079) UDP-glucose
4-epimerase (galE-1) [Archaeoglobus fulgidus]
Length = 305
Score = 330 bits (838), Expect = 1e-89
Identities = 168/312 (53%), Positives = 228/312 (72%), Gaps = 15/312 (4%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
++VTGGAGFIGSH+VD+L E E+ V+D+LS+G+ E +N + D++DY
Sbjct: 2 IVVTGGAGFIGSHVVDKLSESN-EIVVIDNLSSGNEEFVNEAARLVKADLAADDIKDY-- 58
Query: 63 VKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSST 122
+ E V+H+AANP+VRI +++P+ +Y NVL TY LL+A+R++ V +VFTS+ST
Sbjct: 59 ----LKGAEEVWHIAANPDVRIGAENPDEIYRNNVLATYRLLEAMRKAGVSRIVFTSTST 114
Query: 123 VYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSNH 182
VYG+A V+PTPE Y P PIS+YG +KLA EALI Y H F +A I+R AN+IG+RS H
Sbjct: 115 VYGEAKVIPTPEDY-PTHPISLYGASKLACEALIESYCHTFDMQAWIYRFANVIGRRSTH 173
Query: 183 GVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNLGN 242
GVIYDFI KLKRNP ELEILG+G+Q KSY+++SD ++ +L + R ++ +++N+G+
Sbjct: 174 GVIYDFIMKLKRNPEELEILGNGEQNKSYIYISDCVDAML----FGLRGDERVNIFNIGS 229
Query: 243 EDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNS 302
ED I VK IAEIV EE+GLSP+F+FTG G RGWKGDV MLLSIEK K+ GW+P+ NS
Sbjct: 230 EDQIKVKRIAEIVCEELGLSPRFRFTG---GDRGWKGDVPVMLLSIEKLKRLGWKPRYNS 286
Query: 303 YEAVRRTVRELL 314
EAVR VR+L+
Sbjct: 287 EEAVRMAVRDLV 298
>emb|CAC11160.1| (AL445063) UDP-glucose 4-epimerase related protein [Thermoplasma
acidophilum]
Length = 312
Score = 282 bits (713), Expect = 5e-75
Identities = 145/312 (46%), Positives = 207/312 (65%), Gaps = 9/312 (2%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
V++TGGAGFIGS++V+ L+ED +V V+D+LS + ++ +NF FI+ D+ +
Sbjct: 6 VMITGGAGFIGSNMVEMLLEDN-DVTVIDNLSIMDDRYIKPFMGKKNFRFIKEDITE--- 61
Query: 63 VKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSST 122
D ++V HLAA+ +VR S P + +NV+ T N+L+ +R+ +VK ++F SSST
Sbjct: 62 -SVTPGDYDLVVHLAADSDVRNGSVDPTIDLRSNVIGTVNVLEMMRKKDVKDILFASSST 120
Query: 123 VYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSNH 182
+YG+A V+PTPE YGPL PIS YG +KL+AEA IS Y+H +G A IFR ANI+GK S H
Sbjct: 121 IYGEAKVMPTPEDYGPLLPISSYGASKLSAEAFISSYSHYYGINAKIFRFANIVGKNSTH 180
Query: 183 GVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNLGN 242
GVI+DFINKLK+N ELE+LGDG Q KSY+HV+D + + +I++ +V+NLGN
Sbjct: 181 GVIFDFINKLKKNSKELEVLGDGTQAKSYMHVTDCVGSMFYIYDRISGT----EVFNLGN 236
Query: 243 EDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNS 302
+D V IA+ V E MGL G GRGW GDVK+ + I+K K TGW+ + NS
Sbjct: 237 DDVTNVDTIAKYVIEAMGLRDTRIVRKGGYMGRGWPGDVKYARMDIKKLKATGWKNRYNS 296
Query: 303 YEAVRRTVRELL 314
+AV+ + E++
Sbjct: 297 DQAVKVAIGEIM 308
>gb|AAK40511.1| UDP-glucose 4-epimerase (galE-2) [Sulfolobus solfataricus]
Length = 311
Score = 273 bits (690), Expect = 2e-72
Identities = 149/315 (47%), Positives = 209/315 (66%), Gaps = 17/315 (5%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKIV 63
+VTGGAG+IG HLVD L+ EV V+DDLS G N E +F+ D+R +
Sbjct: 3 IVTGGAGYIGGHLVDYLISKNLEVIVIDDLSYGKYRN-------EKAKFVMFDLRQN--M 53
Query: 64 KEAVDDVE---VVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
E V+ +E +++HLAANP+VR S + E +E +V +T N+++ R + + ++FTSS
Sbjct: 54 GELVEKLEKNPIIYHLAANPDVRTSMINVEEHFERDVKVTLNVMELARRVDAEKVIFTSS 113
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
STVYG+ + +PTPES L+PIS YG KL E ++ YA +G +++ RLANI G R
Sbjct: 114 STVYGETSKIPTPESE-ELKPISNYGLFKLLCENIVKYYAEQYGIKSISTRLANITGGRV 172
Query: 181 NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNL 240
+HGV+ DFI KLK NPN LEILG+GKQRKSYL++ D I + + K+ N+I+DV+N+
Sbjct: 173 SHGVVIDFIKKLKDNPNLLEILGNGKQRKSYLYIDDLIEAFVML---EKKVNRIYDVFNI 229
Query: 241 GNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEK-AKKTGWRPK 299
GN D ITV EIA+IV +EM LSP+ + GRGW GDV+ MLL I K +++ GW PK
Sbjct: 230 GNNDSITVDEIAKIVIDEMKLSPRITYKNPTADGRGWPGDVRLMLLDISKISREVGWSPK 289
Query: 300 MNSYEAVRRTVRELL 314
M+S E +R+ V++LL
Sbjct: 290 MSSREVIRQAVKDLL 304
>gb|AAG19227.1| (AE005019) UDP-glucose 4-epimerase; GalE1 [Halobacterium sp. NRC-1]
Length = 314
Score = 255 bits (644), Expect = 6e-67
Identities = 145/317 (45%), Positives = 192/317 (59%), Gaps = 15/317 (4%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
+++VTGGAG +GSH L D +V V DDLS GS E + + EF R DM D
Sbjct: 7 RIVVTGGAGLVGSHAAGALAGDN-DVLVADDLSKGSREAVP-----DGVEFRRRDMCDPD 60
Query: 62 IVKEAVD-DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
V + + DV++VFH AA + + P L+E N +TYN+L+ + V FTSS
Sbjct: 61 DVADVITPDVDIVFHFAAYTDTNY--EQPRQLFEENGAMTYNVLERMAAVGVDRFAFTSS 118
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
STVYG+A +PTPE Y PLEPISVYG +KLA E LIS YAH G + ++R ANI+G R
Sbjct: 119 STVYGEAP-MPTPEDYAPLEPISVYGASKLADEGLISTYAHAHGITSWVYRFANIVGPRQ 177
Query: 181 NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNL 240
V+ DFI KL+ +P L ILGDG+Q KSYLHV D ++ + H+ E+ ++ +V+NL
Sbjct: 178 RGTVVPDFIQKLRADPETLTILGDGRQEKSYLHVEDCVDAMTHVIEH--APSRPLNVFNL 235
Query: 241 GNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKM 300
G +V IA++VS+E+G+ P +++TG G RGW GDV M LSIEK GW P
Sbjct: 236 GTRTTTSVTAIADLVSDELGVDPAYEYTG---GDRGWTGDVPRMRLSIEKLAALGWEPTR 292
Query: 301 NSYEAVRRTVRELLGVL 317
S EAVR EL L
Sbjct: 293 ASDEAVRTAAAELAAEL 309
>pir||S44960 lmbM protein - Streptomyces lincolnensis >gi|487703|emb|CAA55759.1|
(X79146) lmbM [Streptomyces lincolnensis]
Length = 324
Score = 210 bits (530), Expect = 1e-53
Identities = 129/316 (40%), Positives = 175/316 (54%), Gaps = 12/316 (3%)
Query: 5 VTGGAGFIGSHLVDRLMEDGY---EVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
VTGGAGFIGSH V+ G EV DDLS + L +E F+R D+ D
Sbjct: 7 VTGGAGFIGSHFVETAPRRGRHPGEVVAYDDLSNTTTGGFEPLLADERLRFVRADVLDTA 66
Query: 62 IVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
+ E + + V HLA++ ++R T ++L A+R S + ++F+S
Sbjct: 67 RLTEELTGWTQDDVVHLASSVDMRKGYHDRGFDLRQCAEGTLSVLNAMRASGPRTVLFSS 126
Query: 120 SSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKR 179
SSTVYGD LPTPE GP PIS+YG KLAAEAL+S H+ GF A +FR N++G R
Sbjct: 127 SSTVYGDPVTLPTPEHAGPYAPISMYGAGKLAAEALLSANCHLDGFTAHVFRFGNVVGGR 186
Query: 180 SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYN 239
NHGVI+DFI KL + L++LGDG+QRK+Y V + ++GIL + F V N
Sbjct: 187 MNHGVIHDFIEKLDARRDRLQVLGDGRQRKNYFLVEECVDGIL---TASGKLGPGFHVLN 243
Query: 240 LGNEDWITVKEIAEIVSEEMGL-SPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRP 298
LGN ++V EIA IV +EMGL + GGV RGW GDV + + + + GW
Sbjct: 244 LGNPGTVSVDEIAAIVIDEMGLKGVGLEHEGGV---RGWPGDVPVVEYDLTRVHELGWSA 300
Query: 299 KMNSYEAVRRTVRELL 314
+ +A+R R LL
Sbjct: 301 PTDGRQAIRTCARRLL 316
>pir||S69807 lmbM protein - Streptomyces lincolnensis
Length = 322
Score = 199 bits (502), Expect = 3e-50
Identities = 126/312 (40%), Positives = 175/312 (55%), Gaps = 12/312 (3%)
Query: 8 GAGFIGSHLVDRLM-EDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKIVKEA 66
GAGFIGSH V+RL+ E+G DDLS + + L +E F+R D+ D + E
Sbjct: 10 GAGFIGSHFVERLLAEEGTRGVAYDDLSNTTTRWIEPLLADERLRFVRADVLDTARLTEE 69
Query: 67 VDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSSTVY 124
+ + V HLA++ ++R T ++L A+R S + ++F+SSSTVY
Sbjct: 70 LTGWTQDDVCHLASSVDMRKGYHDRGFDLRQCAEGTLSVLNAMRASGPRTVLFSSSSTVY 129
Query: 125 GD-ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSNHG 183
GD +LPTPE GP PIS+YG KLAAE L+S H+ GF A +FR N++G R NHG
Sbjct: 130 GDPVTLLPTPEHAGPYAPISMYGAGKLAAEGLLSANCHLDGFTAHVFRFGNVVGGRMNHG 189
Query: 184 VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNLGNE 243
VI+DFI KL L++LGDG+QRK+Y V + ++GIL + F V NLGN
Sbjct: 190 VIHDFIEKLDARRVRLQVLGDGRQRKNYFLVEECVDGIL---TASGKLGPGFHVLNLGNP 246
Query: 244 DWITVKEIAEIVSEEMGL-SPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNS 302
++V EIA IV +EMGL + GGV RGW GDV + + + + GW +
Sbjct: 247 GTVSVDEIAAIVIDEMGLKGVGLEHEGGV---RGWPGDVP-VEYDLTRVHELGWSAPTDG 302
Query: 303 YEAVRRTVRELL 314
+A+R R LL
Sbjct: 303 RQAIRTCARRLL 314
>sp|Q57664|GALE_METJA PUTATIVE UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|2129343|pir||D64326 UDPglucose
4-epimerase (EC 5.1.3.2) - Methanococcus jannaschii
>gi|1590951|gb|AAB98196.1| (U67477) UDP-glucose
4-epimerase (galE) [Methanococcus jannaschii]
Length = 305
Score = 180 bits (451), Expect = 3e-44
Identities = 112/315 (35%), Positives = 180/315 (56%), Gaps = 27/315 (8%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
+LVTGGAGFIGSH+VD+L+E+ Y+V +LD+L+ G+ N+ N EF+ D+RD K
Sbjct: 2 ILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGNKNNI-----NPKAEFVNADIRD-KD 55
Query: 63 VKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ E ++ DVEVV H AA VR S ++P + NVL T N+L+ +R+ ++ +VF SS
Sbjct: 56 LDEKINFKDVEVVIHQAAQINVRNSVENPVYDGDINVLGTINILEMMRKYDIDKIVFASS 115
Query: 121 -STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKR 179
VYG+ N LP E++ P+ P+S YG +K E I Y ++G I R +N+ G+R
Sbjct: 116 GGAVYGEPNYLPVDENH-PINPLSPYGLSKYVGEEYIKLYNRLYGIEYAILRYSNVYGER 174
Query: 180 SN----HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
+ GVI FI+K+ +N + + I GDG Q + +++V D L +
Sbjct: 175 QDPKGEAGVISIFIDKMLKNQSPI-IFGDGNQTRDFVYVGDVAKANLMALNWKN------ 227
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTG 295
++ N+G +V E+ +I+ E+G F G + +G+V + L I+KA+ G
Sbjct: 228 EIVNIGTGKETSVNELFDIIKHEIG------FRGEAIYDKPREGEVYRIYLDIKKAESLG 281
Query: 296 WRPKMNSYEAVRRTV 310
W+P+++ E ++R V
Sbjct: 282 WKPEIDLKEGIKRVV 296
>pir||C72368 hypothetical protein TM0509 - Thermotoga maritima (strain MSB8)
>gi|4981021|gb|AAD35594.1|AE001727_6 (AE001727)
UDP-glucose 4-epimerase, putative [Thermotoga maritima]
Length = 309
Score = 164 bits (412), Expect = 9e-40
Identities = 116/321 (36%), Positives = 177/321 (55%), Gaps = 31/321 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M +LVTGGAGFIGSH+VD+L+E+GY V V+D+LS+G +ENLNR N F + D
Sbjct: 1 MNILVTGGAGFIGSHVVDKLIENGYGVIVVDNLSSGKVENLNR-----NALFYEQSIEDE 55
Query: 61 KIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
++++ ++ E VFHLAA V IS + P +TN++ + LL+ + VK +F+
Sbjct: 56 EMMERIFSLHRPEYVFHLAAQASVAISVREPARDAKTNIIGSLVLLEKSIKYGVKKFIFS 115
Query: 119 SS-STVYGD-ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S+ +YG+ V PTPE+ P PIS YG AK + E + +A +G + + R AN+
Sbjct: 116 STGGAIYGENVKVFPTPETEIP-HPISPYGIAKYSTEMYLEFFAREYGLKYTVLRYANVY 174
Query: 177 GKRSN----HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R + GV+ F ++ R E+ I GDG+ + Y++V D + L E K N
Sbjct: 175 GPRQDPYGEAGVVAIFTERMLRG-EEVHIFGDGEYVRDYVYVDDVVRANLLAME--KGDN 231
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGL--SPKFKFTGGVDGGRGWKGDVKFMLLSIEK 290
++F N+G TV ++ +++ E G P +K KGDV+ +L K
Sbjct: 232 EVF---NIGTGRGTTVNQLFKLLKEITGYDKEPVYK--------PPRKGDVRKSILDYTK 280
Query: 291 AK-KTGWRPKMNSYEAVRRTV 310
AK K GW PK++ E ++ TV
Sbjct: 281 AKEKLGWEPKVSLEEGLKLTV 301
>pir||D75143 udp-glucose 4-epimerase (gale-1) PAB2145 - Pyrococcus abyssi
(strain Orsay) >gi|5457737|emb|CAB49227.1| (AJ248284)
UDP-glucose 4-epimerase (galE-1) [Pyrococcus abyssi]
Length = 307
Score = 163 bits (409), Expect = 2e-39
Identities = 107/310 (34%), Positives = 167/310 (53%), Gaps = 21/310 (6%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
++VTGGAGFIGSH+ + L E+ +V V+D+L +G EN+ E +FI D+RDY+
Sbjct: 6 IVVTGGAGFIGSHIAEALKEEN-DVVVIDNLYSGKPENVP-----EGVKFIEADVRDYES 59
Query: 63 VKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSST 122
+ E V + VFH AA V S + P E NV+ T N+L+A+ E N K L+F SS+
Sbjct: 60 IAEIVSSADYVFHEAAQISVEESVKDPVFTEEVNVIGTINILRALSEGNGK-LIFASSAA 118
Query: 123 VYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSNH 182
VYG+ LP E + PL PIS YG +K++ E + ++G +I R N+ G R +
Sbjct: 119 VYGEPTSLPIREDH-PLNPISPYGVSKVSGEHYCKVFYQLYGVPTVILRYFNVYGPRQSS 177
Query: 183 ---GVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYN 239
GVI F+ + R L I GDGKQ + +++V D + + + E + + + F N
Sbjct: 178 AYAGVISIFMERALRG-EPLVIFGDGKQSRDFVYVKDVVEANILVAEKRRAEGETF---N 233
Query: 240 LGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPK 299
+G T+ E+A + E S + F+ + GD++ + IEK KK G++P+
Sbjct: 234 VGTGRETTIIELAMKIIELSSTSSQILFS------KPRPGDIRRSVADIEKIKKLGFKPR 287
Query: 300 MNSYEAVRRT 309
+ E + T
Sbjct: 288 YSLEEGLLET 297
>dbj|BAB07368.1| (AP001519) UDP-glucose 4-epimerase [Bacillus halodurans]
Length = 311
Score = 159 bits (398), Expect = 4e-38
Identities = 107/318 (33%), Positives = 174/318 (54%), Gaps = 25/318 (7%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
KVLVTGGAGFIGSHLVD L+ +G EV ++D+LS+GSL+++ + + + D+ D +
Sbjct: 3 KVLVTGGAGFIGSHLVDLLIAEGTEVVIVDNLSSGSLKHV-----HPSSHLFKLDILDER 57
Query: 62 I--VKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
+ V + D++ + HLAA +V S +P + N+ T LL+ R+ VK VF S
Sbjct: 58 VADVFQEHPDIDRIVHLAAQSKVGPSVLNPTYDAQVNIQGTIRLLEFSRKYGVKQFVFAS 117
Query: 120 SSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKR 179
S+ +YG ++ LP E + P P+S YG +K AAEA + Y ++G + R AN+ G R
Sbjct: 118 SAAIYGPSHTLPIREEF-PALPLSPYGTSKYAAEAYVKTYGRLYGLNVHVLRFANVYGPR 176
Query: 180 ----SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
+ GVI FI KL +N + I GDGKQ + ++ V D +N I E Q ++
Sbjct: 177 QTAETEAGVISIFIEKLLKNEQPI-IFGDGKQTRDFIFVLDVVNAIRSCLETETNQ-EVD 234
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMGL--SPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK 293
VYN+ +V+++ + + ++ + +P F+ + GD+K L +K +K
Sbjct: 235 PVYNVSTGLQTSVEDLLKELCAQLNVTYAPAFE--------QERSGDIKHSCLDQQKLQK 286
Query: 294 -TGWRPKMNSYEAVRRTV 310
W P++ E + +T+
Sbjct: 287 HLTWNPRIALNEGLAKTI 304
>pir||A71183 probable UDP-glucose 4-epimerase - Pyrococcus horikoshii
>gi|3258173|dbj|BAA30856.1| (AP000007) 306aa long
hypothetical UDP-glucose 4-epimerase [Pyrococcus
horikoshii]
Length = 306
Score = 157 bits (392), Expect = 2e-37
Identities = 105/313 (33%), Positives = 169/313 (53%), Gaps = 23/313 (7%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
+++TGGAGFIGSHL + L ++ +V ++D+L +G +EN+ E +FIR D+RDY+
Sbjct: 6 IVITGGAGFIGSHLAEALKDEN-DVIIIDNLYSGRIENI-----PEGVKFIRADVRDYES 59
Query: 63 VKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSST 122
+ E + + + VFH AA V+ S + P E NV+ T N+L+A+ + + K L+F SS+
Sbjct: 60 IAEVISEADYVFHEAAQISVKESIEDPVFTEEVNVIGTINVLRALSQGDGK-LIFASSAA 118
Query: 123 VYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSNH 182
VYG+ LP E PIS YG KLAAE Y ++G +I R N+ G R +
Sbjct: 119 VYGEPKELPITED-TLTNPISPYGITKLAAEHYCRVYQSLYGIPVVILRYFNVYGPRQSS 177
Query: 183 ---GVIYDFINK-LKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVY 238
GVI F+ + +K P L I GDGKQ + +++V D + + + + +IF+V
Sbjct: 178 AYAGVISIFLERAIKGEP--LIIFGDGKQTRDFIYVKDVVEANILVAKKRSANGRIFNVA 235
Query: 239 NLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRP 298
G E T+ E+A + + S F GD++ + IE+ KK G++P
Sbjct: 236 T-GKE--TTILELAMKIIDMTSSSSSILFY------PPRPGDIRRSVAKIERIKKLGFKP 286
Query: 299 KMNSYEAVRRTVR 311
+ + E ++ T +
Sbjct: 287 RYSLEEGLKETFK 299
>gb|AAK41108.1| UDP-glucose 4-epimerase (galE-2) [Sulfolobus solfataricus]
Length = 310
Score = 150 bits (374), Expect = 3e-35
Identities = 104/327 (31%), Positives = 175/327 (52%), Gaps = 30/327 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+L++GGAGF+GSHL + L+E G E+ ++DDLS N+ + + EFI+ + ++
Sbjct: 3 MKILISGGAGFLGSHLTEALLEKGEEITIVDDLSTAKYFNIRK-----DVEFIKKKVEEF 57
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ K+ +VV HLAA P + P +N L TY +L+ R+SN +F ++TSS
Sbjct: 58 ETEKK----YDVVIHLAARPSPEDYIEHPVDTALSNSLGTYKMLEIARKSNARF-IYTSS 112
Query: 121 STVYGDANVLPTPESY-GPLEPI---SVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S VYG A+++PTPE+Y G + PI S Y +K +EALI Y + I R N+
Sbjct: 113 SEVYGSASIIPTPETYWGYVNPIGIRSCYDESKRFSEALIMAYHRQYKLDTRIQRPFNVY 172
Query: 177 G----KRSNHG-VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQ 231
G + +G V+ FI + + ++ + GDG Q +++L++SD ++ + + +
Sbjct: 173 GPGLREDGTYGRVVSRFIYQALKG-EDVTVFGDGNQTRAFLYISDWVDATIKL---IYKD 228
Query: 232 NKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKA 291
+V+N+G++ I + E+A ++ + G + K+ D I KA
Sbjct: 229 GLEGEVFNIGSDKEIKIIELANMIIKLTGSKSRIKYL------PPRPDDPPRRAADITKA 282
Query: 292 K-KTGWRPKMNSYEAVRRTVRELLGVL 317
K K GW PK++ E ++ T+ GVL
Sbjct: 283 KEKLGWYPKISLEEGLKLTINWFKGVL 309
>emb|CAB57495.1| (Y18930) dTDP-glucose 4,6-dehydratase [Sulfolobus solfataricus]
Length = 310
Score = 150 bits (374), Expect = 3e-35
Identities = 104/327 (31%), Positives = 175/327 (52%), Gaps = 30/327 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+L++GGAGF+GSHL + L+E G E+ ++DDLS N+ + + EFI+ + ++
Sbjct: 3 MKILISGGAGFLGSHLTEALLEKGEEITIVDDLSTAKYFNIRK-----DVEFIKKKVEEF 57
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ K+ +VV HLAA P + P +N L TY +L+ R+SN +F ++TSS
Sbjct: 58 ETEKK----YDVVIHLAARPSPEDYIEHPVDTALSNSLGTYKMLEIARKSNARF-IYTSS 112
Query: 121 STVYGDANVLPTPESY-GPLEPI---SVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S VYG A+++PTPE+Y G + PI S Y +K +EALI Y + I R N+
Sbjct: 113 SEVYGSASIIPTPETYWGYVNPIGIRSCYDESKRFSEALIMAYHRQYKLDTRIQRPFNVY 172
Query: 177 G----KRSNHG-VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQ 231
G + +G V+ FI + + ++ + GDG Q +++L++SD ++ + + +
Sbjct: 173 GPGLREDGTYGRVVSRFIYQALKG-EDVTVFGDGNQTRAFLYISDWVDATIKL---IYKD 228
Query: 232 NKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKA 291
+V+N+G++ I + E+A ++ + G + K+ D I KA
Sbjct: 229 GLEGEVFNIGSDKEIKIIELANMIIKLTGSKSRIKYL------PPRPDDPPRRAADITKA 282
Query: 292 K-KTGWRPKMNSYEAVRRTVRELLGVL 317
K K GW PK++ E ++ T+ GVL
Sbjct: 283 KEKLGWYPKISLEEGLKLTINWFKGVL 309
>pir||D70696 probable dtdp-glucose 4 - Mycobacterium tuberculosis (strain H37RV)
>gi|1552867|emb|CAB02463.1| (Z80343) epiB [Mycobacterium
tuberculosis]
Length = 326
Score = 146 bits (366), Expect = 2e-34
Identities = 102/316 (32%), Positives = 156/316 (49%), Gaps = 18/316 (5%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M++LVTGGAGF GSHL + L+ +G+ V VLD S ++ N+ + ++ FI G + D
Sbjct: 1 MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDG 60
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ + AV D VVFHLAA+ V S PE ETNV+ TY +L+A+R + L++ S+
Sbjct: 61 QTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNR-LIYVST 119
Query: 121 STVYGDANVLPTPE---SYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
VYGD + L E + L+P S YG +K AA+ L Y +G I R NI G
Sbjct: 120 CEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFG 179
Query: 178 KRSNHGVIYDFINKLKR---NPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
R G I +L R N L I G G + YL+VSD + + + +
Sbjct: 180 VRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQ- 238
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKT 294
N + V++I E V++ KF ++ G+V+ I AK
Sbjct: 239 --AINFASGKDTRVRDIVEYVAD--------KFGARIEHRDARPGEVQRFPADISLAKSI 288
Query: 295 GWRPKMNSYEAVRRTV 310
G++P++ ++ + R +
Sbjct: 289 GFQPQVEIWDGIDRYI 304
>pir||C83136 probable epimerase PA4068 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950266|gb|AAG07455.1|AE004823_1
(AE004823) probable epimerase [Pseudomonas aeruginosa]
Length = 309
Score = 146 bits (365), Expect = 3e-34
Identities = 92/267 (34%), Positives = 140/267 (51%), Gaps = 13/267 (4%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
+L+TGGAGFIGSHL D L+ GY VRVLD+LS G +NL L++E E + GD D
Sbjct: 6 ILITGGAGFIGSHLTDALLARGYRVRVLDNLSTGKRDNLP--LDDERVELLEGDAADAAT 63
Query: 63 VKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSST 122
+ A+ V HLAA V+ S P +++N + T NL +A+RE VK +VF SS+
Sbjct: 64 LAAALKGCAAVAHLAAVASVQASVDDPVATHQSNFIATLNLCEAMREQGVKRVVFASSAA 123
Query: 123 VYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSN- 181
VYG + P P++ Y KLA+E + Y G IFR N+ G R +
Sbjct: 124 VYGQNGEGTAIDEDTPKSPLTPYASDKLASEYYLDFYRRQHGLEPAIFRFFNVYGPRQDP 183
Query: 182 ----HGVIYDFINK-LKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFD 236
GVI F + LK P + + GDG+Q + +++V+D ++ ++ E +
Sbjct: 184 SSPYSGVISIFTERALKGTP--ITVFGDGEQTRDFIYVADLVDFLVQALEATAVEP---G 238
Query: 237 VYNLGNEDWITVKEIAEIVSEEMGLSP 263
N+G I++K++ + + +G P
Sbjct: 239 AVNVGLNRSISLKQLLAEIGQVLGGLP 265
>dbj|BAB09774.1| (AB016890) dTDP-glucose 4-6-dehydratase [Arabidopsis thaliana]
Length = 342
Score = 146 bits (364), Expect = 4e-34
Identities = 110/316 (34%), Positives = 160/316 (49%), Gaps = 29/316 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME-DGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
M++L++GGAGFIGSHLVD+LME + EV V D+ GS ENL +W+ + FE IR D+ +
Sbjct: 30 MRILISGGAGFIGSHLVDKLMENEKNEVVVADNYFTGSKENLKKWIGHPRFELIRHDVTE 89
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++ +V+ ++HLA +P +TNV+ T N+L + + L+ TS
Sbjct: 90 PLLI-----EVDRIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGARILL-TS 143
Query: 120 SSTVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANI 175
+S VYGD + P PESY G + PI V Y K AE L+ Y G I R+ N
Sbjct: 144 TSEVYGDPLIHPQPESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNT 203
Query: 176 IGKRSN---HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R N V+ +FI + R L + G Q +S+ +VSD ++G++ + E
Sbjct: 204 YGPRMNIDDGRVVSNFIAQALRG-EALTVQKPGTQTRSFCYVSDMVDGLIRLME-----G 257
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGV-DGGRGWKGDVKFMLLSIEKA 291
N+GN T+ E+AE V E + S + K D R K D I KA
Sbjct: 258 NDTGPINIGNPGEFTMVELAETVKELINPSIEIKMVENTPDDPRQRKPD-------ISKA 310
Query: 292 KKT-GWRPKMNSYEAV 306
K+ GW PK+ E +
Sbjct: 311 KEVLGWEPKVKLREGL 326
>pir||T45701 dTDP-glucose 4-6-dehydratases-like protein - Arabidopsis thaliana
>gi|6522623|emb|CAB62035.1| (AL133298) dTDP-glucose
4-6-dehydratases-like protein [Arabidopsis thaliana]
Length = 341
Score = 144 bits (360), Expect = 1e-33
Identities = 109/316 (34%), Positives = 160/316 (50%), Gaps = 29/316 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME-DGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
M++L++GGAGFIGSHLVD+LME + EV V D+ GS +NL +W+ + FE IR D+ +
Sbjct: 29 MRILISGGAGFIGSHLVDKLMENEKNEVIVADNYFTGSKDNLKKWIGHPRFELIRHDVTE 88
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++ +V+ ++HLA +P +TNV+ T N+L + + L+ TS
Sbjct: 89 PLLI-----EVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGARILL-TS 142
Query: 120 SSTVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANI 175
+S VYGD + P PESY G + PI V Y K AE L+ Y G I R+ N
Sbjct: 143 TSEVYGDPLIHPQPESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNT 202
Query: 176 IGKRSN---HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R N V+ +FI + R L + G Q +S+ +VSD ++G++ + E
Sbjct: 203 YGPRMNIDDGRVVSNFIAQALRG-EALTVQKPGTQTRSFCYVSDMVDGLMRLME-----G 256
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGV-DGGRGWKGDVKFMLLSIEKA 291
N+GN T+ E+AE V E + S + K D R K D I KA
Sbjct: 257 DDTGPINIGNPGEFTMVELAETVKELINPSIEIKMVENTPDDPRQRKPD-------ITKA 309
Query: 292 KKT-GWRPKMNSYEAV 306
K+ GW PK+ E +
Sbjct: 310 KEVLGWEPKVKLREGL 325
>dbj|BAB07098.1| (AP001518) UDP-glucose 4-epimerase [Bacillus halodurans]
Length = 308
Score = 143 bits (358), Expect = 2e-33
Identities = 101/321 (31%), Positives = 157/321 (48%), Gaps = 33/321 (10%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
KVLVTGGAGFIGSH+V+ L+ GYEV V+D+L+ G EN++ + N F + D
Sbjct: 4 KVLVTGGAGFIGSHIVELLLNKGYEVVVVDNLTTGQFENISSF----NVPFYKTD----- 54
Query: 62 IVKEAVDDV------EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
IV + D+ V H AA +V S P ETN++ T NLL + V +
Sbjct: 55 IVSSELKDIFSKEKPNYVIHHAAQVDVTKSINLPTYDAETNIIGTINLLSCCCQYEVDKV 114
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
++ SS VYGD E + P++PIS YG +K E I + ++G + IFR AN+
Sbjct: 115 IYASSCAVYGDTGDSSITEDF-PIQPISFYGISKSVPEMYIRQFHDLYGLKYTIFRYANV 173
Query: 176 IGKRSNH----GVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQ 231
G R GVI F K + + I G+G+Q + +++V D +
Sbjct: 174 YGPRQTSKGEGGVISIFTTKALKREQPI-IYGNGEQTRDFIYVEDIAKANALALDIGDN- 231
Query: 232 NKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKA 291
+++N+G ++ E+ V+ +P K+T + GD+ LS KA
Sbjct: 232 ----EIFNIGTNQKTSINELYNKVNVVRPFAPSAKYTSPRE------GDILHSRLSYVKA 281
Query: 292 KK-TGWRPKMNSYEAVRRTVR 311
KK GW+P ++ ++ T++
Sbjct: 282 KKILGWKPSVSLERGIQETLK 302
>pir||T00419 dTDP-glucose 4-6-dehydratase homolog T30B22.4 - Arabidopsis
thaliana >gi|3738279|gb|AAC63621.1| (AC005309) putative
nucleotide-sugar dehydratase [Arabidopsis thaliana]
Length = 443
Score = 141 bits (353), Expect = 8e-33
Identities = 106/309 (34%), Positives = 156/309 (50%), Gaps = 28/309 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
++V+VTGGAGF+GSHLVDRLM G V V+D+ G EN+ N NFE IR D
Sbjct: 121 LRVVVTGGAGFVGSHLVDRLMARGDNVIVVDNFFTGRKENVMHHFNNPNFEMIRHD---- 176
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+V+ + +V+ ++HLA +P +TNV+ T N+L + +FL+ TS+
Sbjct: 177 -VVEPILLEVDQIYHLACPASPVHYKFNPVKTIKTNVVGTLNMLGLAKRVGARFLL-TST 234
Query: 121 STVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S VYGD P E+Y G + PI V Y K AE L Y I R+ N
Sbjct: 235 SEVYGDPLQHPQVETYWGNVNPIGVRSCYDEGKRTAETLTMDYHRGANVEVRIARIFNTY 294
Query: 177 GKR---SNHGVIYDFI-NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R + V+ +F+ L++ P L + GDGKQ +S+ VSD + G++ + E
Sbjct: 295 GPRMCIDDGRVVSNFVAQALRKEP--LTVYGDGKQTRSFQFVSDLVEGLMRLME-----G 347
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAK 292
+ +NLGN T+ E+A++V E + + K +F + D I KAK
Sbjct: 348 EHVGPFNLGNPGEFTMLELAKVVQETIDPNAKIEFRPNTE------DDPHKRKPDITKAK 401
Query: 293 K-TGWRPKM 300
+ GW PK+
Sbjct: 402 ELLGWEPKV 410
>pir||S58282 dTDP-glucose 4-6-dehydratase homolog D18 - Arabidopsis thaliana
>gi|928932|emb|CAA89205.1| (Z49239) homolog of
dTDP-glucose 4-6-dehydratases [Arabidopsis thaliana]
>gi|1585435|prf||2124427B diamide resistance gene
[Arabidopsis thaliana]
Length = 445
Score = 140 bits (350), Expect = 2e-32
Identities = 106/321 (33%), Positives = 161/321 (50%), Gaps = 28/321 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
++V+VTGGAGF+GSHLVDRLM G V V+D+ G EN+ N NFE IR D
Sbjct: 119 LRVVVTGGAGFVGSHLVDRLMARGDTVIVVDNFFTGRKENVMHHFSNPNFEMIRHD---- 174
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+V+ + +V+ ++HLA +P +TNV+ T N+L + +FL+ TS+
Sbjct: 175 -VVEPILLEVDQIYHLACPASPVHYKFNPVKTIKTNVVGTLNMLGLAKRVGARFLL-TST 232
Query: 121 STVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S VYGD P E+Y G + PI V Y K AE L Y I R+ N
Sbjct: 233 SEVYGDPLQHPQVETYWGNVNPIGVRSCYDEGKRTAETLTMDYHRGSNVEVRIARIFNTY 292
Query: 177 GKR---SNHGVIYDFI-NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R + V+ +F+ L++ P L + GDGKQ +S+ VSD + G++ + E
Sbjct: 293 GPRMCIDDGRVVSNFVAQALRKEP--LTVYGDGKQTRSFQFVSDLVEGLMRLME-----G 345
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAK 292
+ +NLGN T+ E+A++V E + + +F + D I KAK
Sbjct: 346 EHVGPFNLGNPGEFTMLELAKVVQETIDPNANIEFRPNTE------DDPHKRKPDITKAK 399
Query: 293 K-TGWRPKMNSYEAVRRTVRE 312
+ GW PK++ + + V++
Sbjct: 400 ELLGWEPKVSLRQGLPLMVKD 420
>pir||T48072 dTDP-glucose 4-6-dehydratase homolog D18 - Arabidopsis thaliana
>gi|7362763|emb|CAB83133.1| (AL162651) dTDP-glucose
4-6-dehydratase homolog D18 [Arabidopsis thaliana]
Length = 445
Score = 140 bits (350), Expect = 2e-32
Identities = 106/321 (33%), Positives = 161/321 (50%), Gaps = 28/321 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
++V+VTGGAGF+GSHLVDRLM G V V+D+ G EN+ N NFE IR D
Sbjct: 119 LRVVVTGGAGFVGSHLVDRLMARGDTVIVVDNFFTGRKENVMHHFSNPNFEMIRHD---- 174
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+V+ + +V+ ++HLA +P +TNV+ T N+L + +FL+ TS+
Sbjct: 175 -VVEPILLEVDQIYHLACPASPVHYKFNPVKTIKTNVVGTLNMLGLAKRVGARFLL-TST 232
Query: 121 STVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S VYGD P E+Y G + PI V Y K AE L Y I R+ N
Sbjct: 233 SEVYGDPLQHPQVETYWGNVNPIGVRSCYDEGKRTAETLTMDYHRGANVEVRIARIFNTY 292
Query: 177 GKR---SNHGVIYDFI-NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R + V+ +F+ L++ P L + GDGKQ +S+ VSD + G++ + E
Sbjct: 293 GPRMCIDDGRVVSNFVAQALRKEP--LTVYGDGKQTRSFQFVSDLVEGLMRLME-----G 345
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAK 292
+ +NLGN T+ E+A++V E + + +F + D I KAK
Sbjct: 346 EHVGPFNLGNPGEFTMLELAKVVQETIDPNANIEFRPNTE------DDPHKRKPDITKAK 399
Query: 293 K-TGWRPKMNSYEAVRRTVRE 312
+ GW PK++ + + V++
Sbjct: 400 ELLGWEPKVSLRQGLPLMVKD 420
>gb|AAF50474.1| (AE003556) CG7979 gene product [Drosophila melanogaster]
Length = 441
Score = 140 bits (349), Expect = 2e-32
Identities = 101/317 (31%), Positives = 160/317 (49%), Gaps = 26/317 (8%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
++L+TGGAGF+GSHLVD LM G+EV V+D+ G N+ WL +ENFE I D
Sbjct: 117 RILITGGAGFVGSHLVDDLMVQGHEVIVVDNFFTGRKRNVEHWLGHENFELIHHD----- 171
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
IV +++ ++HLA+ +P +TN + T N+L + K L+ S+S
Sbjct: 172 IVNPLFIEIDEIYHLASPASPPHYMYNPVKTIKTNTMGTINVLGLAKRVMAKVLI-ASTS 230
Query: 122 TVYGDANVLPTPESY----GPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
VYGD V P PE+Y P+ P + Y K +E L YA + + R+ N G
Sbjct: 231 EVYGDPTVHPQPETYWGHVNPIGPRACYDEGKRVSETLSYAYAKQEKVQVRVARIFNTYG 290
Query: 178 KR--SNHG-VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
R N G V+ +FI + RN + + G+GKQ +S+ +VSD ++G++ + +
Sbjct: 291 PRMHMNDGRVVSNFILQALRN-ETITVYGNGKQTRSFQYVSDLVDGMIALM-----ASNY 344
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK- 293
NLGN T+ E AEI+ + +G P + + + D + I +A++
Sbjct: 345 TQPVNLGNPVEQTIGEFAEIIKKLVG-GPSV-----IKQSKAMEDDPQRRKPDITRARQL 398
Query: 294 TGWRPKMNSYEAVRRTV 310
W PK+ ++RT+
Sbjct: 399 LHWEPKVPLETGLQRTI 415
>gb|AAC79582.1| (AC005727) putative nucleotide-sugar dehydratase [Arabidopsis
thaliana]
Length = 343
Score = 140 bits (349), Expect = 2e-32
Identities = 110/316 (34%), Positives = 156/316 (48%), Gaps = 29/316 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME-DGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
M++LVTGGAGFIGSHLVD+LM+ + EV V D+ GS +NL +W+ + FE IR D+ +
Sbjct: 31 MRILVTGGAGFIGSHLVDKLMQNEKNEVIVADNYFTGSKDNLKKWIGHPRFELIRHDVTE 90
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
V +V+ ++HLA +P +TNV+ T N+L + + L+ TS
Sbjct: 91 PLFV-----EVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGARILL-TS 144
Query: 120 SSTVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANI 175
+S VYGD V P ESY G + PI V Y K AE L+ Y G I R+ N
Sbjct: 145 TSEVYGDPLVHPQTESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNT 204
Query: 176 IGKRSN---HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R N V+ +FI + R L + G Q +S+ +VSD + G++ + E
Sbjct: 205 YGPRMNIDDGRVVSNFIAQALRG-EALTVQKPGTQTRSFCYVSDMVEGLMRLME-----G 258
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGV-DGGRGWKGDVKFMLLSIEKA 291
N+GN T+ E+AE V E + + K D R K D I KA
Sbjct: 259 DQTGPINIGNPGEFTMVELAETVKELIKPDVEIKMVENTPDDPRQRKPD-------ISKA 311
Query: 292 KKT-GWRPKMNSYEAV 306
K+ GW PK+ E +
Sbjct: 312 KEVLGWEPKVKLREGL 327
>gi|11497937 dTDP-glucose 4,6-dehydratase (rfbB) [Archaeoglobus fulgidus]
>gi|7437239|pir||D69290 dTDP-glucose 4,6-dehydratase
(rfbB) homolog - Archaeoglobus fulgidus
>gi|2650312|gb|AAB90911.1| (AE001082) dTDP-glucose
4,6-dehydratase (rfbB) [Archaeoglobus fulgidus]
Length = 332
Score = 139 bits (346), Expect = 5e-32
Identities = 106/315 (33%), Positives = 160/315 (50%), Gaps = 16/315 (5%)
Query: 1 MKVLVTGGAGFIGSHLVD-RLMEDGYEVRVLDDLSAGSL-ENLNRWLENENFEFIRGDMR 58
M++LVTGG GFIGS+ V L E+ LD L GS ENL E+E + FI+GD+
Sbjct: 1 MRILVTGGMGFIGSNFVRYALAHHQVEILNLDALKYGSNPENLKDLAEDERYSFIKGDIN 60
Query: 59 DYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF-LVF 117
DY++V + + V+ V + AA V S SP E+N L Y +L+A+R+ N + LV
Sbjct: 61 DYELVSDLIKKVDAVVNFAAESHVDRSISSPYAFIESNFLGVYTILEAVRKCNPEVRLVH 120
Query: 118 TSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
S+ VYGD E G L P S Y +K AA+ L+ GYA + A I R N G
Sbjct: 121 VSTDEVYGDIEKGSFTEKDG-LMPSSPYSASKAAADMLVLGYARTYNLNASITRCTNNYG 179
Query: 178 K-RSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFD 236
+ +I I + K N + + I G G + +++V D + + E +R+ +
Sbjct: 180 PYQFPEKLIPKTIIRAKMNLS-VPIYGTGMNVRDWIYVEDHCRAVWEVMEKGERR----E 234
Query: 237 VYNLGNEDWITVKEIAEIVSEEMGLSPK-FKFTGGVDGGRGWKGDVKFMLLSIEKAKKTG 295
VYN+ + + T EI + + E MG ++ G DV++ L S + ++
Sbjct: 235 VYNISSGEERTNLEIVKTILEIMGKDESLIEYVEDRPG-----HDVRYSLDSWKIMRELK 289
Query: 296 WRPKMNSYEAVRRTV 310
WRPK++ E +RRTV
Sbjct: 290 WRPKISFEEGIRRTV 304
>gb|AAG18701.1| (AE004975) UDP-glucose 4-epimerase; GalE2 [Halobacterium sp. NRC-1]
Length = 328
Score = 138 bits (345), Expect = 7e-32
Identities = 94/322 (29%), Positives = 161/322 (49%), Gaps = 23/322 (7%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDD--------LSAGSLENLNRWLENEN--F 50
M++LVTGGAGFIG HL +R + G++V VLD+ + ++E ++ + +
Sbjct: 1 MRILVTGGAGFIGGHLAERFVSRGHDVVVLDNFDPFYDTRIKDHTVEVCQNLADDGDGSY 60
Query: 51 EFIRGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRES 110
+ GD+RD ++V+E V DV+ V+H A VR S + P E NV T N+L A R++
Sbjct: 61 RLVEGDVRDAELVEELVADVDYVYHQAGQAGVRPSVEDPRKYNEVNVDGTLNVLDAARKT 120
Query: 111 NVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIF 170
++ +VF SSS+VYG LP E + P P+S YG +KLAAE + Y+ ++ +
Sbjct: 121 EIERVVFASSSSVYGKPEYLPYDEVH-PTTPVSPYGASKLAAERYVCAYSEVYDLPTVAL 179
Query: 171 RLANIIGKRSNHGV-IYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFK 229
R + G R + I +F+++ N + GDG Q + + ++ D ++ +
Sbjct: 180 RYFTVYGPRMRPNMAISNFVSRC-LNGEPPVVYGDGTQTRDFTYIEDVVDANEALLTDDA 238
Query: 230 RQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIE 289
+V N+G+ D I + +AE + +++ +F ++ D + I
Sbjct: 239 ADG---EVLNIGSTDNIDILTLAEEIRDQVAPELDIEF------AERFEADAEHTHADIS 289
Query: 290 KAKK-TGWRPKMNSYEAVRRTV 310
KA + G+ P E V+ V
Sbjct: 290 KANELLGYEPSRTIREGVQEFV 311
>pir||T45892 dTDP-glucose 4-6-dehydratase-like protein - Arabidopsis thaliana
>gi|6729503|emb|CAB67659.1| (AL132966) dTDP-glucose
4-6-dehydratase-like protein [Arabidopsis thaliana]
Length = 433
Score = 138 bits (344), Expect = 9e-32
Identities = 109/321 (33%), Positives = 161/321 (49%), Gaps = 30/321 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
++++VTGGAGF+GSHLVD+L+ G EV V+D+ G ENL N FE IR D
Sbjct: 120 LRIVVTGGAGFVGSHLVDKLIGRGDEVIVIDNFFTGRKENLVHLFSNPRFELIRHD---- 175
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+V+ + +V+ ++HLA +P +TNV+ T N+L + +FL+ TS+
Sbjct: 176 -VVEPILLEVDQIYHLACPASPVHYKYNPVKTIKTNVMGTLNMLGLAKRVGARFLL-TST 233
Query: 121 STVYGDANVLPTPESY-GPLEPI---SVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S VYGD P E+Y G + PI S Y K AE L Y G I R+ N
Sbjct: 234 SEVYGDPLEHPQKETYWGNVNPIGERSCYDEGKRTAETLAMDYHRGAGVEVRIARIFNTY 293
Query: 177 GKR---SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
G R + V+ +F+ + R + + + GDGKQ +S+ +VSD G++ + E N
Sbjct: 294 GPRMCLDDGRVVSNFVAQTIRK-HPMTVYGDGKQTRSFQYVSDL--GLVALME-----ND 345
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF-TGGVDGGRGWKGDVKFMLLSIEKAK 292
+NLGN T+ E+AE+V E + S +F D K D I KAK
Sbjct: 346 HVGPFNLGNPGEFTMLELAEVVKEVIDPSATIEFKPNTADDPHKRKPD-------ISKAK 398
Query: 293 -KTGWRPKMNSYEAVRRTVRE 312
+ W PK++ E + R V +
Sbjct: 399 EQLNWEPKISLREGLPRMVSD 419
>pir||S75550 dTDP-glucose 4-6-dehydratase - Synechocystis sp. (strain PCC 6803)
>gi|1653195|dbj|BAA18111.1| (D90911) dTDP-glucose
4-6-dehydratase [Synechocystis sp.]
Length = 328
Score = 136 bits (339), Expect = 3e-31
Identities = 94/261 (36%), Positives = 135/261 (51%), Gaps = 21/261 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M++LVTGGAGFIGSHL+DRLM G+EV LD+ G+ N+ +WL+N NFE IR D
Sbjct: 20 MRILVTGGAGFIGSHLIDRLMAQGHEVLCLDNFYTGTKRNIVQWLDNPNFELIRHD---- 75
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ + +V+ V+HLA +P +TNV+ T +L + +FL+ S+
Sbjct: 76 -VTEPIRLEVDQVYHLACPASPVHYQFNPVKTIKTNVMGTLYMLGLAKRVGARFLL-AST 133
Query: 121 STVYGDANVLPTPESY----GPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S VYGD +V P PESY + P + Y K AE L Y + R+ N
Sbjct: 134 SEVYGDPDVHPQPESYRGNVNTIGPRACYDEGKRVAETLAFEYYREHKVDIRVARIFNTY 193
Query: 177 GKR--SNHG-VIYDFI-NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R N G V+ +FI L+ P L + GDG Q +S+ +VSD + G++ +
Sbjct: 194 GPRMLENDGRVVSNFIVQALQGKP--LTVFGDGSQTRSFCYVSDLVEGLMRLM-----NG 246
Query: 233 KIFDVYNLGNEDWITVKEIAE 253
NLGN T+ ++AE
Sbjct: 247 DYVGPVNLGNPGEYTILQLAE 267
>gb|AAD12951.1| (AF078135) unknown [Leptospira borgpetersenii]
Length = 332
Score = 136 bits (338), Expect = 4e-31
Identities = 104/325 (32%), Positives = 163/325 (50%), Gaps = 26/325 (8%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE------NENFEFIRG 55
K+LVTG GFIGSHL + L+ G+EV+ ++ N WL+ FE G
Sbjct: 3 KILVTGADGFIGSHLTEALVRLGFEVKAFVYYNSF---NTWGWLDYCSSDVRGKFEIFTG 59
Query: 56 DMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
D+RD V+ A+ ++ V HLAA + S SP+ +TN+ T N+LQA R+ N+ +
Sbjct: 60 DVRDPNGVRTAMKGIDAVLHLAALIGIPYSYHSPDTYVDTNIKGTLNVLQAARDLNLSRV 119
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
+ TS+S VYG A +P E + PL+ S Y +K+ A+ L + F +I R N
Sbjct: 120 IHTSTSEVYGTAQFVPITEEH-PLKGQSPYSASKIGADQLAYSFYSSFSTPVIIVRPFNT 178
Query: 176 IGKR-SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
G R S +I I +L +++ LG + + V+DT+NG + K + +
Sbjct: 179 YGPRQSARAIIPTVITQLLSGKTKIQ-LGSTSPTRDFNFVTDTVNGFI---SALKSKQGL 234
Query: 235 FDVYNLGNEDWI----TVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEK 290
+V N+GN I TVK IA I+ +E+ + V+ R K +V+ + S +K
Sbjct: 235 GEVINIGNGFEISVGDTVKLIASILDKEV------EIVSDVNRIRPEKSEVERLWSSNQK 288
Query: 291 AKKT-GWRPKMNSYEAVRRTVRELL 314
AK GW+P + E +R + E +
Sbjct: 289 AKDLFGWQPAYSGLEGFKRGLTETI 313
>pir||T51252 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [imported] - chickpea
>gi|6469141|emb|CAB61752.1| (AJ275318) dTDP-glucose
4-6-dehydratase [Cicer arietinum]
Length = 346
Score = 136 bits (338), Expect = 4e-31
Identities = 107/310 (34%), Positives = 154/310 (49%), Gaps = 29/310 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME-DGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
M++LVTGGAGFIGSHLVDRLME + EV V D+ GS +NL +W+ + FE IR D+ +
Sbjct: 33 MRILVTGGAGFIGSHLVDRLMENEKNEVIVADNYFTGSKDNLKKWIGHPRFELIRHDVTE 92
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++ +V+ ++HLA +P +TNV+ T N+L + + L+ TS
Sbjct: 93 PLMI-----EVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGARILL-TS 146
Query: 120 SSTVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANI 175
+S VYGD P ESY G + P V Y K AE L+ Y G + R+ N
Sbjct: 147 TSEVYGDPLEHPQTESYWGNVNPNGVRNCYDEGKRVAETLMFDYHRQHGIEIRVARIFNT 206
Query: 176 IGKRSN---HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R N V+ +FI + R L + G Q +S+ +VSD ++G++ +
Sbjct: 207 YGPRMNIDDGRVVSNFIAQALRG-ESLTVQSPGTQTRSFCYVSDLVDGLIRLM-----GG 260
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGV-DGGRGWKGDVKFMLLSIEKA 291
NLGN T+ E+AE V E + + + K D R K D I KA
Sbjct: 261 SDTGPINLGNPGEFTMLELAETVKELINPNVEIKTVENTPDDPRQRKPD-------ITKA 313
Query: 292 KK-TGWRPKM 300
K+ GW PK+
Sbjct: 314 KELLGWEPKV 323
>pir||C70562 probable DTDP-Glucose 4 - Mycobacterium tuberculosis (strain H37RV)
>gi|2105060|emb|CAB08849.1| (Z95436) rmlB2
[Mycobacterium tuberculosis]
Length = 314
Score = 135 bits (337), Expect = 6e-31
Identities = 101/318 (31%), Positives = 155/318 (47%), Gaps = 21/318 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDM--R 58
M+ LVTG AGFIGS LVDRL+ DG+ V LD+ + G NL +N F+ D+
Sbjct: 1 MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTA 60
Query: 59 DYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
D + E EVVFHLAA +VR S P+ NV+ T L +A R++ V+ +V T
Sbjct: 61 DLHAILEQ-HRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHT 119
Query: 119 SS-STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
SS ++YG PTPE+ P +P S Y K+A E ++ + H++G AN+ G
Sbjct: 120 SSGGSIYGTPPEYPTPET-APTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYG 178
Query: 178 KRSN----HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
R + GV+ F L + + GDG + Y+ V D ++ + + +
Sbjct: 179 PRQDPHGEAGVVAIFAQAL-LSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLR 237
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK 293
+N+G + +++ V+ +G +F GD+K L I A++
Sbjct: 238 ----FNIGTGKETSDRQLHSAVAAAVGGPDDPEF------HPPRLGDLKRSCLDIGLAER 287
Query: 294 T-GWRPKMNSYEAVRRTV 310
GWRP++ + VRRTV
Sbjct: 288 VLGWRPQIELADGVRRTV 305
>emb|CAC14890.1| (AJ295156) d-TDP-glucose dehydratase [Phragmites australis]
Length = 350
Score = 134 bits (335), Expect = 1e-30
Identities = 106/310 (34%), Positives = 154/310 (49%), Gaps = 29/310 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME-DGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
+++LVTGGAGFIGSHLVD+LME + +EV V D+ GS +NL +W+ + FE IR D+
Sbjct: 35 LRILVTGGAGFIGSHLVDKLMENEKHEVIVADNFFTGSKDNLKKWIGHPRFELIRHDVTQ 94
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
+V +V+ ++HLA +P +TNV+ T N+L + + L+ TS
Sbjct: 95 PLLV-----EVDQIYHLACPASPIFYKHNPVKTIKTNVIGTLNMLGLAKRVGARILL-TS 148
Query: 120 SSTVYGDANVLPTPESY-GPLEPISV---YGGAKLAAEALISGYAHIFGFRALIFRLANI 175
+S VYGD P E+Y G + PI V Y K AE L+ Y G I R+ N
Sbjct: 149 TSEVYGDPLEHPQTEAYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNT 208
Query: 176 IGKRSN---HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G R N V+ +FI + R + L + G Q +S+ +V+D ++G++ +
Sbjct: 209 YGPRMNIDDGRVVSNFIAQAVRG-DPLTVQKPGTQTRSFCYVADMVDGLIKLM-----NG 262
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGV-DGGRGWKGDVKFMLLSIEKA 291
NLGN T+ E+AE V E + T D R K D I KA
Sbjct: 263 NNTGPINLGNPGEFTMLELAEKVKELINPEVTVTMTENTPDDPRQRKPD-------ITKA 315
Query: 292 KKT-GWRPKM 300
K+ GW PK+
Sbjct: 316 KEVLGWEPKV 325
>gb|AAD52168.1|AF144879_7 (AF144879) unknown [Leptospira interrogans]
Length = 332
Score = 133 bits (331), Expect = 3e-30
Identities = 97/321 (30%), Positives = 159/321 (49%), Gaps = 18/321 (5%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE------NENFEFIRG 55
K+LVTG GFIGSHL + L+ G+EV+ ++ N WL+ FE G
Sbjct: 3 KILVTGADGFIGSHLTEALVRSGFEVKAFVYYNSF---NTWGWLDYCSDDVRGKFEIFTG 59
Query: 56 DMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
D+RD V+ A+ + V HLAA + S SP+ +TN+ T N+LQA R+ N+ +
Sbjct: 60 DVRDPNGVRTAMKGTDAVLHLAALIGIPYSYHSPDTYIDTNIKGTLNVLQAARDLNLSKV 119
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
+ TS+S VYG A +P E + PL+ S Y +K+ A+ L + F +I R N
Sbjct: 120 IHTSTSEVYGTAQFVPITEEH-PLKGQSPYSASKIGADQLAYSFYSSFSTPVIIVRPFNT 178
Query: 176 IGKR-SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
G R S +I I +L +++ LG + + V+DT+NG + K +
Sbjct: 179 YGPRQSARAIIPTVITQLLSGKTKVQ-LGSTSPTRDFNFVTDTVNGFI---SALKSKQGF 234
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK- 293
+V N+GN I+V + ++++ +G + + + R K +V+ + S +KAK
Sbjct: 235 GEVINIGNGFEISVGDTVKLIANIIG--KEIEIVSDSNRIRPEKSEVERLWASNQKAKDL 292
Query: 294 TGWRPKMNSYEAVRRTVRELL 314
W+P N + R+ + E +
Sbjct: 293 LNWQPAYNGLQGFRKGLEETI 313
>pir||H69105 dTDP-glucose 4,6-dehydratase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622920|gb|AAB86255.1| (AE000933)
dTDP-glucose 4,6-dehydratase [Methanobacterium
thermoautotrophicum]
Length = 336
Score = 132 bits (330), Expect = 4e-30
Identities = 95/315 (30%), Positives = 152/315 (48%), Gaps = 17/315 (5%)
Query: 2 KVLVTGGAGFIGSHLVD-RLMEDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
K+LVTGGAGFIGS+ + L E Y + LD L+ G+LENL + + F+RG + D
Sbjct: 3 KILVTGGAGFIGSNFIRYMLQEHPYHIINLDALTYCGNLENLRGVEDEPRYTFVRGSITD 62
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
K+V + DV+ V + AA V S + PE+ TN+L T LL+A R+ V+ + S
Sbjct: 63 RKLVDGIIKDVDAVINFAAESHVDRSIEDPEIFIRTNILGTQTLLEASRKHGVERFIQIS 122
Query: 120 SSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKR 179
+ VYG A E PL P S Y +K +A+ ++ Y +G I R +N G
Sbjct: 123 TDEVYGSAEKGYFTEE-TPLAPNSPYSASKASADLMVRAYHRTYGLPVNITRCSNNYGPY 181
Query: 180 SNHGVIYDFI--NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDV 237
+ + N L+ P L + GDG + ++HV D + + + ++ +V
Sbjct: 182 QFPEKLIPLMITNALENKP--LPVYGDGMNVRDWIHVLDHCRAV----DLVLHRGRVGEV 235
Query: 238 YNLGNEDWITVKEIAEIVSEEMGLSPK-FKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGW 296
YN+G EI E++ E+G +F G D ++ + + + + GW
Sbjct: 236 YNIGGNSERRNIEIVELIVRELGKDESLIRFVEDRPG-----HDRRYAIDASKIRNELGW 290
Query: 297 RPKMNSYEAVRRTVR 311
+P + E +R T+R
Sbjct: 291 KPLYSFEEGIRETIR 305
>sp|Q58455|YA55_METJA HYPOTHETICAL PROTEIN MJ1055 >gi|2127791|pir||F64431 capsular
polysaccharide biosynthesis protein I homolog -
Methanococcus jannaschii >gi|1591707|gb|AAB99057.1|
(U67548) capsular polysaccharide biosynthesis protein I
[Methanococcus jannaschii]
Length = 326
Score = 131 bits (326), Expect = 1e-29
Identities = 93/322 (28%), Positives = 158/322 (48%), Gaps = 32/322 (9%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW------------LEN-EN 49
+LVTG AGFIG HL LM D YE DL ++NLN + L+N EN
Sbjct: 6 ILVTGSAGFIGFHLSKYLM-DNYE-----DLKVIGIDNLNNYYNPVLKEKRNEILKNYEN 59
Query: 50 FEFIRGDMRDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAI 107
+ FI+ D D+ + E + D E+ + HL A VR S Q+P ++N + T N+ +
Sbjct: 60 YTFIKLDFSDWDDLVENLKDKEIDLIVHLGAQAGVRYSLQNPWAYIKSNEMGTLNIFEFA 119
Query: 108 RESNVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRA 167
R +++ +V+ SSS+VYG +P E +PIS+Y K + E + Y H++G +
Sbjct: 120 RRFDIEKVVYASSSSVYGGNRKIPFSEDDRVDKPISLYASTKRSNELMAHVYHHLYGIKM 179
Query: 168 LIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEY 227
+ R + G+ + Y K E+E+ G + + ++SD ++GIL
Sbjct: 180 IGLRFFTVYGEYGRPDMAYFKFAKNILLGKEIEVYNYGNMERDFTYISDVVDGILRAI-- 237
Query: 228 FKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLS 287
+++ ++++NLGN + + E++ + + K KF D GDV
Sbjct: 238 --KKDFDYEIFNLGNSKPVKLMYFIELIEKYLNKKAKKKFLPMQD------GDVLRTYAD 289
Query: 288 IEKAKK-TGWRPKMNSYEAVRR 308
+ K++K G++PK+ E ++R
Sbjct: 290 LSKSEKLLGYKPKVTIEEGLKR 311
>gb|AAA68211.1| (L37354) thymidine diphosphoglucose 4,6-dehydratase
[Saccharopolyspora erythraea]
Length = 329
Score = 130 bits (324), Expect = 2e-29
Identities = 96/268 (35%), Positives = 135/268 (49%), Gaps = 14/268 (5%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY------EVRVLDDLS-AGSLENLNRWLENENFEFI 53
M+VLVTGGAGFIGSH V +L+ Y +V VLD L+ AG+ ENL ++ F F+
Sbjct: 1 MRVLVTGGAGFIGSHYVRQLLGGAYPAFAGADVVVLDKLTYAGNEENLRPVADDPRFRFV 60
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
RGD+ ++ +V E + +V+VV H AA V S TNV+ T LLQ +NV
Sbjct: 61 RGDICEWDVVSEVMREVDVVVHFAAETHVDRSILGASDFVVTNVVGTNTLLQGALAANVS 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
V S+ VYG PE + LEP S Y AK ++ + Y G I R +
Sbjct: 121 KFVHVSTDEVYGTIEHGSWPEDH-LLEPNSPYSAAKAGSDLIARAYHRTHGLPVCITRCS 179
Query: 174 NIIGK-RSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
N G + V+ FI L + + + GDG + +LHV+D GI + E
Sbjct: 180 NNYGPYQFPEKVLPLFITNL-MDGRRVPLYGDGLNVRDWLHVTDHCRGIQLVAE----SG 234
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMG 260
+ ++YN+G +T KE+ E V E MG
Sbjct: 235 RAGEIYNIGGGTELTNKELTERVLELMG 262
>gb|AAF25549.1|AF109295_4 (AF109295) GalE [Staphylococcus carnosus]
Length = 329
Score = 129 bits (321), Expect = 4e-29
Identities = 95/328 (28%), Positives = 153/328 (45%), Gaps = 32/328 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M VLV GGAG+IGSH D+L+E GY+V V+D+L G +R E F GD+RD
Sbjct: 1 MSVLVLGGAGYIGSHAADQLIEQGYDVAVVDNLGTG-----HRQAVPETARFYEGDIRDK 55
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ ++VE VFH A V S + P + NV LL+ ++ +V ++F+
Sbjct: 56 AFLNHVFEQENVEGVFHFCAYSLVGESVEKPLEYFNNNVYGMQVLLEVMKAHDVNEIIFS 115
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ VYG+ ++P E P P + YG +KL E ++ + +G R N+ G
Sbjct: 116 STAAVYGEPEIIPIQED-APKAPTNPYGESKLMMEKMMHWCHNAYGVNYAALRYFNVAGA 174
Query: 179 RSNHGVIYDFINKLKRNP----------NELEILG------DGKQRKSYLHVSDTINGIL 222
+ + + D + P + + I G DG + YLHV+D I +
Sbjct: 175 KEDGSIGEDHNPETHLIPIVLQAALGQRDAITIFGTDYDTEDGSCVRDYLHVTDLIAAHI 234
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVK 282
++Y K + +NLG+ +V EI E + G+ K + G GD
Sbjct: 235 LAYQYLKDGGE-SGAFNLGSSQGYSVIEIVEAARKATGIDIKAEI------GERRAGDPS 287
Query: 283 FMLLSIEKAKKT-GWRPKMNSYEAVRRT 309
++ S +KA++ GW+PK + + T
Sbjct: 288 KLVASSDKAQRVLGWKPKHDDIHEIIET 315
>pir||C69149 conserved hypothetical protein MTH380 - Methanobacterium
thermoautotrophicum (strain Delta H)
Length = 341
Score = 129 bits (321), Expect = 4e-29
Identities = 105/326 (32%), Positives = 153/326 (46%), Gaps = 35/326 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M V VTGG GFIGSHL D L+E G V V+DDLS GS +NL R +E+ E I G + D
Sbjct: 29 MDVAVTGGLGFIGSHLTDELLERGNRVTVIDDLSTGSPDNL-RDPHHEDLEIIEGSINDL 87
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ K + VFH AA V S + P + N T +L A + V+ +V S+
Sbjct: 88 DLEK-VFQGKDYVFHQAALASVPESVRDPLRCHRVNATGTLRVLMASSRAGVRKVVNAST 146
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF---GFRALIFRLANIIG 177
S VYG+ +P E P+ P+S Y +K+ E Y +F G + R N+ G
Sbjct: 147 SAVYGNNPEIPLREDARPM-PLSPYAVSKVTGEY----YCQVFEDQGLETVSLRYFNVYG 201
Query: 178 KRSN-----HGVIYDFINKL--KRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKR 230
R VI FI+ L R+P EI GDG+Q + +++V D + F
Sbjct: 202 PRQRPDSQYAAVIPRFIDALLSGRSP---EIYGDGEQSRDFIYVGDVVRA-----NIFLA 253
Query: 231 QNKIFDVYNLGNEDWITVKEIAEIVSE--EMGLSPKFKFTGGVDGGRGWKGDVKFMLLSI 288
+++ VYN+ +TV + +I+S E P++ GDV+ L
Sbjct: 254 ESRGSGVYNVAGGSSVTVNRLFDIISGILESDAEPEYLDER--------PGDVRHSLADT 305
Query: 289 EKAKKTGWRPKMNSYEAVRRTVRELL 314
+ G+RP++ E + RTV L
Sbjct: 306 SRLAAAGFRPEVGLEEGLMRTVEWFL 331
>pir||D81275 probable nucleotide sugar dehydratase Cj1319 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968753|emb|CAB73746.1| (AL139078) putative
nucleotide sugar dehydratase [Campylobacter jejuni]
Length = 323
Score = 129 bits (321), Expect = 4e-29
Identities = 93/316 (29%), Positives = 157/316 (49%), Gaps = 21/316 (6%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENF----EFIRGD 56
+LVTG GFIGSHL + L++ G++VR L ++ N W LE F E I GD
Sbjct: 4 ILVTGADGFIGSHLCESLVKKGFKVRALSQYNS-----FNFWGHLEKSPFLKDMEVISGD 58
Query: 57 MRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+RD ++ +++ +FHL A + S +P+ +TNV T N+L+A +++ + +
Sbjct: 59 LRDSFFCEKITKNIDAIFHLGALIAIPYSYTAPQSYVDTNVNGTLNMLEAAKKNEISHFI 118
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
TS+S VYG A +P E + PL+P S Y +K+AA+ + Y + F I R N
Sbjct: 119 HTSTSEVYGTAFYVPIDEKH-PLQPQSPYSASKIAADMMALSYYNSFNLNVNIARPFNTY 177
Query: 177 GKR-SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
G R S +I I ++ E++ LGD ++ V DT G + +
Sbjct: 178 GPRQSARAIIPTIITQILSGAKEIK-LGDLSPKRDLNFVLDTCEGFISLLNL----KHFG 232
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK-T 294
+VYN+G+ +++E+ +++ + L K K R +V + K KK T
Sbjct: 233 EVYNIGSGVEYSMQEVLDLIQKI--LDSKVKIIQDEQRLRPKNSEVFRLCCDANKLKKAT 290
Query: 295 GWRPKMNSYEAVRRTV 310
W+ K++ E +R+++
Sbjct: 291 NWQSKISLEEGLRQSI 306
>gb|AAB84886.1| (AE000823) UDP-glucose 4-epimerase homolog [Methanobacterium
thermoautotrophicum]
Length = 316
Score = 129 bits (321), Expect = 4e-29
Identities = 105/326 (32%), Positives = 153/326 (46%), Gaps = 35/326 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M V VTGG GFIGSHL D L+E G V V+DDLS GS +NL R +E+ E I G + D
Sbjct: 4 MDVAVTGGLGFIGSHLTDELLERGNRVTVIDDLSTGSPDNL-RDPHHEDLEIIEGSINDL 62
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ K + VFH AA V S + P + N T +L A + V+ +V S+
Sbjct: 63 DLEK-VFQGKDYVFHQAALASVPESVRDPLRCHRVNATGTLRVLMASSRAGVRKVVNAST 121
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF---GFRALIFRLANIIG 177
S VYG+ +P E P+ P+S Y +K+ E Y +F G + R N+ G
Sbjct: 122 SAVYGNNPEIPLREDARPM-PLSPYAVSKVTGEY----YCQVFEDQGLETVSLRYFNVYG 176
Query: 178 KRSN-----HGVIYDFINKL--KRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKR 230
R VI FI+ L R+P EI GDG+Q + +++V D + F
Sbjct: 177 PRQRPDSQYAAVIPRFIDALLSGRSP---EIYGDGEQSRDFIYVGDVVRA-----NIFLA 228
Query: 231 QNKIFDVYNLGNEDWITVKEIAEIVSE--EMGLSPKFKFTGGVDGGRGWKGDVKFMLLSI 288
+++ VYN+ +TV + +I+S E P++ GDV+ L
Sbjct: 229 ESRGSGVYNVAGGSSVTVNRLFDIISGILESDAEPEYLDER--------PGDVRHSLADT 280
Query: 289 EKAKKTGWRPKMNSYEAVRRTVRELL 314
+ G+RP++ E + RTV L
Sbjct: 281 SRLAAAGFRPEVGLEEGLMRTVEWFL 306
>gi|7657641 dTDP-D-glucose 4,6-dehydratase [Homo sapiens]
>gi|4128133|emb|CAA06840.1| (AJ006068) dTDP-D-glucose
4,6-dehydratase [Homo sapiens]
>gi|5737699|gb|AAD50061.1|AF048686_1 (AF048686)
dTDP-glucose 4,6-dehydratase like protein [Homo sapiens]
Length = 350
Score = 129 bits (320), Expect = 6e-29
Identities = 97/319 (30%), Positives = 161/319 (50%), Gaps = 19/319 (5%)
Query: 2 KVLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
+VLVTGGAGFI SH++ L+ED Y + LD L SL+NL +N++FI+GD+
Sbjct: 19 RVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDIC 78
Query: 59 DYKIVK--EAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D VK + +++V H AA V +S NV T+ L+ A E+ V+ +
Sbjct: 79 DSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFI 138
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
+ S+ VYG + ES P +P + Y +K AAE + Y + F +I R +N+
Sbjct: 139 YVSTDEVYGGSLDKEFDES-SPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVY 197
Query: 177 GKRS-NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
G VI FI+ L+ N + I G G Q +++L+ +D + L + ++ K
Sbjct: 198 GPHQYPEKVIPKFISLLQHN-RKCCIHGSGLQTRNFLYATDVVEAFLTVL----KKGKPG 252
Query: 236 DVYNLGNEDWITV----KEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKA 291
++YN+G ++V KE+ +++ E S + V+ D+++ + S EK
Sbjct: 253 EIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRP--TNDMRYPMKS-EKI 309
Query: 292 KKTGWRPKMNSYEAVRRTV 310
GWRPK+ E +++T+
Sbjct: 310 HGLGWRPKVPWKEGIKKTI 328
>pir||T15892 hypothetical protein D2096.4 - Caenorhabditis elegans
>gi|1065948|gb|AAA81490.1| (U40800) similar to thymidine
diphosphoglucose 4,6-dehydratase [Caenorhabditis
elegans]
Length = 467
Score = 128 bits (318), Expect = 1e-28
Identities = 93/319 (29%), Positives = 160/319 (50%), Gaps = 29/319 (9%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
++L+TGGAGF+GSHLVD+LM DG+EV LD+ G +N+ W+ + NFE + D
Sbjct: 138 RILITGGAGFVGSHLVDKLMLDGHEVIALDNYFTGRKKNVEHWIGHPNFEMVHHD----- 192
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
+V +V+ ++HLA+ +P +TN L T N+L + L+ S+S
Sbjct: 193 VVNPYFVEVDQIYHLASPASPPHYMYNPVKTIKTNTLGTINMLGLAKRVKATVLL-ASTS 251
Query: 122 TVYGDANVLPTPESY----GPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
VYGD V P PE+Y + P + Y K AE+L+ Y + I R+ N G
Sbjct: 252 EVYGDPEVHPQPETYWGHVNTIGPRACYDEGKRVAESLMVAYNKQENIKIRIARIFNTFG 311
Query: 178 KR--SNHG-VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
R N G V+ +FI + ++ + I G+G Q +S+ +V+D ++G++ K N
Sbjct: 312 PRMHMNDGRVVSNFIIQALQD-KPITIYGNGTQTRSFQYVTDLVDGLI------KLMNSN 364
Query: 235 FDV-YNLGNEDWITVKEIAEIVSEEM--GLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKA 291
+ + N+GN + T+ + A I+ + + S D + + D++ A
Sbjct: 365 YSLPVNIGNPEEHTIGQFATIIRDLVPGSTSEIVNLESQQDDPQQRRPDIR------RAA 418
Query: 292 KKTGWRPKMNSYEAVRRTV 310
++ W P+++ + + +TV
Sbjct: 419 EQISWAPQVHMKDGLLKTV 437
>pir||G70415 nucleotide sugar epimerase - Aquifex aeolicus
>gi|2983750|gb|AAC07310.1| (AE000735) nucleotide sugar
epimerase [Aquifex aeolicus]
Length = 321
Score = 128 bits (318), Expect = 1e-28
Identities = 97/327 (29%), Positives = 164/327 (49%), Gaps = 30/327 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAG--------SLENLNRWLENENFEF 52
M +LVTG AG IG + ++L+E G+ V +D+L++ LE L ++ ENF+F
Sbjct: 1 MNILVTGCAGLIGWKVSEKLLEHGHRVIGVDNLNSYYDPRLKEYRLEQLKKF---ENFKF 57
Query: 53 IRGDMRDYKIVKEAVDDVE--VVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRES 110
+ ++ + + ++ + E V + AA VR S Q+P + + TN L NLL+ ++E
Sbjct: 58 YKVNIENREALRILFQEFEFDAVINEAARAGVRYSIQNPHIYFTTNTLGNLNLLELMKEF 117
Query: 111 NVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIF 170
VK L+ S+S++Y +P E PIS Y +K AAE Y +++G +I
Sbjct: 118 GVKKLILASTSSLYA-GQPMPFKEELPVNTPISPYAASKKAAEVTAYTYHYLYGIDVVIL 176
Query: 171 RLANIIGKRSNHGV-IYDFINK-LKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYF 228
R + G + +++FI K LK P +++ GDG Q++ + +V D +
Sbjct: 177 RYFTVYGLAGRPDMAVFNFIYKTLKGIP--IKVYGDGSQKRDFTYVDDVAEATVKALNL- 233
Query: 229 KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSI 288
K +++ N+GN +KE+ E++ + G K V+ G K D++ I
Sbjct: 234 ----KGYEIINVGNNKPRALKELIELIEKYTGKEVK------VEYGDFHKADMRDTWADI 283
Query: 289 EKAKK-TGWRPKMNSYEAVRRTVRELL 314
KAK+ GW PK + E V++TV L
Sbjct: 284 TKAKRLLGWEPKTSLEEGVKKTVEWFL 310
>pir||S75089 UDP-glucose 4-epimerase - Synechocystis sp. (strain PCC 6803)
>gi|1653034|dbj|BAA17951.1| (D90910) UDP-glucose
4-epimerase [Synechocystis sp.]
Length = 338
Score = 127 bits (316), Expect = 2e-28
Identities = 92/318 (28%), Positives = 157/318 (48%), Gaps = 35/318 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
+LVTGGAG+IGSH V L + G++V + D+LS G E ++ E + G D +
Sbjct: 7 ILVTGGAGYIGSHGVLALQQAGFDVLIYDNLSYGHKE----LVQPLGVELVVGHTGDRQK 62
Query: 63 VKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ + A ++ V H AA V S Q P++ Y+ NV+ T LL+A+ + +K VF+S+
Sbjct: 63 LDQLFATRNIAAVMHFAAFIAVGESVQKPDIYYQNNVVGTLTLLEAMLAAGIKKFVFSST 122
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG--- 177
VYG +P ES+ P++P+S Y +K E +++ + +GF+++IFR N G
Sbjct: 123 CAVYGMPKEIPMTESH-PIDPLSPYAASKRMVEQILADFDQAYGFKSVIFRYFNASGADP 181
Query: 178 --------KRSNHGVIYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTINGILH 223
H + + LK+ P +L + G DG + Y+HV D I H
Sbjct: 182 QGRLGEDHNPETHLIPLALLTALKQRP-QLSVFGTDYDTLDGTALRDYIHVCDL--AIAH 238
Query: 224 IFE-YFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVK 282
+ + + +++NLGN + +V+++ E+ GL ++ GD
Sbjct: 239 VLGLQYLLEGGESNIFNLGNGNGFSVRQVIEVAKAVTGLDIPYQLC------PRRPGDAP 292
Query: 283 FMLLSIEKAKK-TGWRPK 299
++ S KA++ GW P+
Sbjct: 293 ILVGSSAKAREILGWNPQ 310
>pir||G71151 probable dTDP-glucose 4,6-dehydratase - Pyrococcus horikoshii
>gi|3256817|dbj|BAA29500.1| (AP000002) 336aa long
hypothetical dTDP-glucose 4,6-dehydratase [Pyrococcus
horikoshii]
Length = 336
Score = 127 bits (315), Expect = 2e-28
Identities = 103/322 (31%), Positives = 158/322 (48%), Gaps = 29/322 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLSAGSLE-NLNRWLENENFEFIRGDM 57
MK+LVTGG GFIGS+ + ++E +EV +D L GS NL ++ + F++GD+
Sbjct: 4 MKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLEDDPRYTFVKGDV 63
Query: 58 RDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESN--VKFL 115
DY++VKE V V+ V HLAA V S SPE+ +NV+ TY LL++IR N V+F
Sbjct: 64 ADYELVKELVRKVDGVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESIRRENPEVRF- 122
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
V S+ VYGD E+ L P S Y K A++ L+ G+ + A I R N
Sbjct: 123 VHVSTDEVYGDILKGSFTEN-DRLMPSSPYSATKAASDMLVLGWTRTYNLNASITRCTNN 181
Query: 176 IGKRSNHGVIYDFINKLKRNP-------NELEILGDGKQRKSYLHVSDTINGILHIFEYF 228
G Y F KL ++ I G GK + +L+V D + I E
Sbjct: 182 YGP-------YQFPEKLIPKTIIRASLGLKIPIYGTGKNVRDWLYVEDHVRAI----ELV 230
Query: 229 KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSI 288
+ + ++YN+ + T E+ +I+ MG + V+ G D+++ L S
Sbjct: 231 LLKGESREIYNISAGEEKTNLEVVKIILRLMGKGE--ELIELVEDRPG--HDLRYSLDSW 286
Query: 289 EKAKKTGWRPKMNSYEAVRRTV 310
+ + WRPK E +++T+
Sbjct: 287 KITRDLKWRPKYTFDEGIKKTI 308
>sp|Q9KDV3|GALE_BACHD UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|10173723|dbj|BAB04827.1| (AP001510)
UDP-glucose 4-epimerase [Bacillus halodurans]
Length = 334
Score = 127 bits (315), Expect = 2e-28
Identities = 102/331 (30%), Positives = 154/331 (45%), Gaps = 45/331 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M +LVTGGAG+IGSH V L+E G +V VLD+L G L+ + F GD+RD
Sbjct: 1 MAILVTGGAGYIGSHTVLFLLEQGEQVIVLDNLQKGHAGALS------DVTFYHGDIRDD 54
Query: 61 KIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+++ ++ V H AAN V S + P YE NV+ T+ LL+ + E +VK +VF+
Sbjct: 55 QLLDTIFTTHSIDTVIHFAANSLVGESVKQPIEYYENNVIGTHTLLKKMLEHDVKKIVFS 114
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ YG+ +P ES P P + YG KLA E + +G + + R N G
Sbjct: 115 STAATYGEPVQIPIQES-DPTIPTNPYGETKLAIEKMFHWCQEAYGLQYVCLRYFNAAGA 173
Query: 179 RSNHGVIYDFINKLKRNPNELEI-LG---------------DGKQRKSYLHVSDTINGIL 222
N + D + P L++ LG DG + Y+HV D N
Sbjct: 174 DPNGRIGEDHSPESHLIPIVLQVALGQRERVAIFGDDYQTEDGSCIRDYIHVMDLANAHY 233
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMG------LSPKFKFTGGVDGGRG 276
E+ ++ + +NLGN +VKE+ E+ + G ++P+
Sbjct: 234 LACEHLRKDGQ-SGSFNLGNGKGFSVKEVIEVCRQVTGHPIPAEIAPR------------ 280
Query: 277 WKGDVKFMLLSIEKAKK-TGWRPKMNSYEAV 306
GD ++ S EKA+ GW PK S E +
Sbjct: 281 RSGDPASLIASSEKAQTILGWEPKYPSLETM 311
>dbj|BAB07428.1| (AP001519) nucleotide sugar epimerase (biosynthesis of
lipopolysaccharide O antigen) [Bacillus halodurans]
Length = 343
Score = 127 bits (315), Expect = 2e-28
Identities = 90/332 (27%), Positives = 163/332 (48%), Gaps = 28/332 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSA---GSLEN--LNRWLENENFEFIRG 55
MK+LVTG AGFIG ++ RL+E+G+ V +D+L+ L+N L + E NFEF +
Sbjct: 1 MKILVTGAAGFIGMYVAKRLLEEGHFVVGIDNLNDYYDPQLKNDRLLQLRELGNFEFHKM 60
Query: 56 DMRDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
D+ + +++ D E+ V +LAA VR S ++P ++N++ NLL++ RE NVK
Sbjct: 61 DLTERDRLRQLFLDKEITHVINLAAQAGVRYSLKNPHAYIDSNLVGFTNLLESCRELNVK 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
L++ SSS+VYG +P S P+S+Y K A E L Y+H++ R
Sbjct: 121 HLIYASSSSVYGANRKMPFATSDEVNHPVSLYAATKKANELLAHSYSHLYHIPTTGLRFF 180
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
+ G + Y K +++ G+ + + ++ D ++G++ + E + +
Sbjct: 181 TVYGPWGRPDMAYFSFTKNIVEGQTIKVFNHGEMMRDFTYIDDIVDGVVALLEQPPQADP 240
Query: 234 IFD--------------VYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG 279
+D +YN+GN + + + E + + +G+ K +F G
Sbjct: 241 NWDFEHPMASSSYAPYKIYNIGNNQPVKLMDFIETLEKHLGIEAKKEFL------PMQPG 294
Query: 280 DVKFMLLSIEKAKK-TGWRPKMNSYEAVRRTV 310
DV+ I+ ++ TG+ P + E +++ V
Sbjct: 295 DVQATYADIDDLQQATGFTPSTSIDEGLKKFV 326
>pir||B75098 dtdp-glucose 4,6-dehydratase (rfbb) PAB0785 - Pyrococcus abyssi
(strain Orsay) >gi|5458599|emb|CAB50087.1| (AJ248286)
dTDP-glucose 4,6-dehydratase (rfbB) [Pyrococcus abyssi]
Length = 333
Score = 125 bits (311), Expect = 7e-28
Identities = 100/325 (30%), Positives = 160/325 (48%), Gaps = 35/325 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME--DGYEVRVLDDLSAGSLE-NLNRWLENENFEFIRGDM 57
M++LVTGG GFIGS+ + ++E + +EV LD L+ GS NL ++ + F++GD+
Sbjct: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
Query: 58 RDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF-LV 116
D+++V+E + V+ + H AA V S SP+ +NV+ TY LL+AIR+ N LV
Sbjct: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S+ VYGD E L P S Y K A++ L+ G+A +G A I R N
Sbjct: 121 HISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
Query: 177 GKRSNHGVIYDFINKL-------KRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFK 229
G Y F KL + ++ I G GK + +L+V D + I E
Sbjct: 180 GP-------YQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAI----EAVL 228
Query: 230 RQNKIFDVYNLGNEDWIT----VKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFML 285
+ + ++YN+ + T V+ I I+ ++ L +F G D+++ L
Sbjct: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMDKDESL---IEFVEDRPG-----HDIRYSL 280
Query: 286 LSIEKAKKTGWRPKMNSYEAVRRTV 310
S + ++ WRPK E +++TV
Sbjct: 281 DSWKIIRELKWRPKYRFEEGIKKTV 305
>emb|CAA18814.1| (AL023093) putative sugar dehyratase [Mycobacterium leprae]
Length = 319
Score = 125 bits (310), Expect = 9e-28
Identities = 98/318 (30%), Positives = 151/318 (46%), Gaps = 21/318 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDM--R 58
++ LVTG AGFIGS LVDRL+ DG+ V LD+ + G NL F+ D+
Sbjct: 6 VRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTA 65
Query: 59 DYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
D + + + EVVFHLAA +VR S P+ NV+ T L +A R + V+ +V T
Sbjct: 66 DLQTILDE-HRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRKIVHT 124
Query: 119 SS-STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
SS ++YG + PTPE+ P +P S Y K+A E ++ + H+ G AN+ G
Sbjct: 125 SSGGSIYGTPSQYPTPETV-PTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYG 183
Query: 178 KRSN----HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
R + GV+ F+ L + ++ GDG + Y+ V D ++ + +
Sbjct: 184 PRQDPYGEAGVVAIFVQAL-LSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGGQR 242
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK 293
+N+G + +++ VS +G +F GD+K L I A
Sbjct: 243 ----FNIGTGIETSDRQLHTAVSAAVGGPDDPEF------HPPRLGDLKRSCLDIGLATT 292
Query: 294 T-GWRPKMNSYEAVRRTV 310
GW P++ + VRRTV
Sbjct: 293 VLGWSPQVQLDDGVRRTV 310
>pir||H69988 NDP-sugar epimerase homolog ytcB - Bacillus subtilis
>gi|2293288|gb|AAC00366.1| (AF008220) YtcB [Bacillus
subtilis] >gi|2635571|emb|CAB15065.1| (Z99119) similar
to NDP-sugar epimerase [Bacillus subtilis]
Length = 316
Score = 125 bits (310), Expect = 9e-28
Identities = 85/280 (30%), Positives = 139/280 (49%), Gaps = 13/280 (4%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDG-YEVRVLDDLSAGS-----LENLNRWLENENFEFIR 54
MK+LVTG AGFIGSHL + L++D + V +DD + L+NL L + F FI+
Sbjct: 1 MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKLKNLKNLLPEKRFTFIK 60
Query: 55 GDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYET-NVLITYNLLQAIRESNVK 113
++ + ++ V+V+FHLAA P VR S + Y N+ LL+A RE +++
Sbjct: 61 ENLLTADLAS-LLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHNIQALQRLLEACREHSIQ 119
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
VF S+S+VYG+ + + L P+S YG KL E L Y FG +I R
Sbjct: 120 TFVFASTSSVYGEKQGKVSENT--SLSPLSPYGVTKLTGEKLCHVYKQSFGIPIVILRFF 177
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
+ G R + + + K L I GDG+Q + + ++SD + GI + + +
Sbjct: 178 TVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYISDCVKGITAV---LGKPHL 234
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
I + N+G + +V ++ ++ + G F+ + G
Sbjct: 235 IGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAG 274
>sp|P33119|GALE_CORDI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|144973|gb|AAA23297.1| (M34239) ORF3
[Corynebacterium diphtheriae] >gi|144977|gb|AAA23300.1|
(M80338) open reading frame [Corynebacterium
diphtheriae]
Length = 328
Score = 124 bits (309), Expect = 1e-27
Identities = 90/321 (28%), Positives = 152/321 (47%), Gaps = 29/321 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+LVTGGAG++GS L+E G+EV ++D+L+ G NR F+ GD++D
Sbjct: 1 MKLLVTGGAGYVGSVCSTVLLEQGHEVTIVDNLTTG-----NRDAVPLGATFVEGDIKDV 55
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ D + V H AA V S + P+ ++ N++ T LL A++ +NV+ +VF+S+
Sbjct: 56 AENVLSSDSFDAVLHFAARSLVGESVEKPDEYWQHNMVTTLALLDAMKRNNVRNIVFSST 115
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
+ YG+ +P E P P + YG KL+ + I+ YAH +GF A R N+ G
Sbjct: 116 AATYGEPETVPITED-APTHPTNPYGATKLSIDYAITSYAHAYGFAATSLRYFNVAGAYG 174
Query: 181 NHG--------VIYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTINGILHIFE 226
G +I + + +++ + G DG + Y+H+ D + HI
Sbjct: 175 LVGENREIETHLIPLVLQVALGHRDKIFMFGDDWPTEDGTPIRDYIHIRDLADA--HILA 232
Query: 227 YFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLL 286
++NLG+ + +VK++ + E G V R GD ++
Sbjct: 233 LQSNVEGSHRIFNLGSGEGYSVKQVIDTCREVTG----HPIPAEVAPRRA--GDPAVLIA 286
Query: 287 SIEKAK-KTGWRPKMNSYEAV 306
S KA+ + GW+P+ +
Sbjct: 287 SSAKAQSELGWKPQRTDLHTI 307
>pir||T35486 probable nucleotide-sugar dehydratase - Streptomyces coelicolor
>gi|4008544|emb|CAA22513.1| (AL034492) putative
nucleotide-sugar dehydratase [Streptomyces coelicolor
A3(2)]
Length = 330
Score = 123 bits (307), Expect = 2e-27
Identities = 97/317 (30%), Positives = 146/317 (45%), Gaps = 21/317 (6%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
+ LVTGGAGF+GSHL RL++ G EV LD+L+ GS N+ F F+RGD D
Sbjct: 18 RALVTGGAGFVGSHLCGRLLDAGTEVVCLDNLATGSRANVADLERRRGFRFVRGDATDPA 77
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
++ ++V H A + P + T N L+ +FL+ S+S
Sbjct: 78 ALRGLPGRFDLVLHFACPASPADYLRLPLETLDVGSTGTRNALERAHADGARFLL-ASTS 136
Query: 122 TVYGDANVLPTPESY----GPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
VYGD P E+Y P+ P SVY +K AEAL++ + + G I R+ N G
Sbjct: 137 EVYGDPLEHPQRETYWGNVNPIGPRSVYDESKRFAEALVTAHRQVHGTDTAIVRIFNTYG 196
Query: 178 KRSNHG---VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
R G + FI + + L + GDG Q +S +V DT+ G+L + +
Sbjct: 197 PRMRTGDGRAVPTFIAQ-ALDGMPLTVAGDGGQTRSLCYVDDTVAGVLAL-----AASGE 250
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFT-GGVDGGRGWKGDVKFMLLSIEKAKK 293
N+G +D IT+ E+A V G + +F VD + D ++
Sbjct: 251 SGPMNIGGDDEITMLELARRVVGLTGSGSRIRFVERPVDDPCRRRPDTTL------ARER 304
Query: 294 TGWRPKMNSYEAVRRTV 310
GWRP ++ E + RT+
Sbjct: 305 LGWRPGVSWNEGLERTI 321
>pir||A69184 UDP-glucose 4-epimerase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621713|gb|AAB85137.1| (AE000844)
UDP-glucose 4-epimerase [Methanobacterium
thermoautotrophicum]
Length = 325
Score = 123 bits (306), Expect = 3e-27
Identities = 98/329 (29%), Positives = 152/329 (45%), Gaps = 40/329 (12%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
+L+ GGAG+IGSH+ L E GYE +LD+L+ G + + +W EFI G++ D ++
Sbjct: 2 ILIVGGAGYIGSHVNKFLSERGYETLILDNLTRGHRDFV-KW-----GEFIEGNLGDRRL 55
Query: 63 VKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ + DV+ V H AA +V S P Y NV+ T NLL ++ + V+ +F+S+
Sbjct: 56 LDRTFETHDVDAVMHFAAFTDVGESVLKPGRYYHNNVVNTINLLDSMVDHGVRDFIFSST 115
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
VYG+ +P E + PL PIS YG +KL E ++ Y +G + R N G
Sbjct: 116 CAVYGNPMEIPISEEH-PLNPISPYGRSKLMVEEILGDYRDAYGLNYVSLRYFNAAGADP 174
Query: 181 NHGV-------------IYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTINGI 221
V + D L+ + + I G DG + Y+HV D +
Sbjct: 175 EGEVGELHNPETHLIPIVLDVALGLR---DAVRIFGTDYPTPDGTCVRDYIHVMDLADAH 231
Query: 222 LHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDV 281
Y + V+NLGN + +V E+ E E G S V+ R GD
Sbjct: 232 WRALRYLEGGES--GVFNLGNGNGFSVMEVIETCREVTGAS-----INAVEDDRR-PGDP 283
Query: 282 KFMLLSIEKAKKT-GWRPKMNSYEAVRRT 309
++ S +A++ GWRP+ E + T
Sbjct: 284 PELVGSAGRARRVLGWRPEFTELEDIIET 312
>sp|Q45291|GALE_BRELA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|2144276|pir||JC5168 UDPglucose
4-epimerase (EC 5.1.3.2) - Corynebacterium glutamicum
>gi|1161517|emb|CAA89986.1| (Z49823) UDP-galactose
4-epimease [Corynebacterium glutamicum]
Length = 329
Score = 122 bits (304), Expect = 4e-27
Identities = 96/316 (30%), Positives = 148/316 (46%), Gaps = 33/316 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+LVTGGAG++GS L+E G++V ++D+ S G NR + I GD+ D
Sbjct: 1 MKLLVTGGAGYVGSVRAAVLLEHGHDVTIIDNFSTG-----NREAVPADARLIEGDVND- 54
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+V+E + E V H AA V S + P + NV+ LL A+R V LVF+
Sbjct: 55 -VVEEVLLEGGFEGVVHFAARSLVGESVEKPNEYWHDNVVTALTLLDAMRAHGVNNLVFS 113
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ YG+ +V+P E P +P + YG KL+ + I+ YA FG A R N+ G
Sbjct: 114 STAATYGEPDVVPITEDM-PTQPTNAYGATKLSIDYAITSYAAAFGLAATSLRYFNVAGA 172
Query: 179 RSNHG--------VIYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTINGILHI 224
N G +I + + ++ + G DG + Y+H+ D H+
Sbjct: 173 YGNIGENREVETHLIPLVLQVATGHREKIFMFGDDWPTPDGTAVRDYIHILDLAKA--HV 230
Query: 225 FEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFM 284
+ ++NLG+ D +VK++ E+ E G V R GD +
Sbjct: 231 LALESNEAGKHRIFNLGSGDGYSVKQVVEMCREVTG----HPIPAEVAPRRA--GDPATL 284
Query: 285 LLSIEKAK-KTGWRPK 299
+ S EKAK + GW P+
Sbjct: 285 IASSEKAKQELGWTPE 300
>gb|AAG18457.1|AF306787_1 (AF306787) AprE [Streptomyces tenebrarius]
Length = 332
Score = 122 bits (304), Expect = 4e-27
Identities = 104/320 (32%), Positives = 154/320 (47%), Gaps = 20/320 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY------EVRVLDDLS-AGSLENLNRWLE--NENFE 51
M+VLVTGGAGFIGSH V L+ Y EV VLD L+ AG+ NL +
Sbjct: 1 MRVLVTGGAGFIGSHYVRELLGGAYPAFADAEVVVLDKLTYAGNEANLAPVADAAGSRLR 60
Query: 52 FIRGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESN 111
F+RGD+ D ++V+ + V+VV H AA V S TNVL T LLQA E+
Sbjct: 61 FVRGDICDAELVRTLMTGVDVVVHFAAESHVDRSILGATEFVMTNVLGTQTLLQAALEAG 120
Query: 112 VKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFR 171
V V S+ VYG + PE + PLEP S Y +K +++ L + G + R
Sbjct: 121 VGKFVHVSTDEVYGSIDEGSWPEDH-PLEPNSPYSASKASSDLLARAFHRTHGLPVCVTR 179
Query: 172 LANIIGK-RSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKR 230
+N G + VI F+ L + + + GDG + +LHV D GI + E
Sbjct: 180 CSNNYGPYQFPEKVIPLFVTNL-MDGRPVPLYGDGLNVRDWLHVDDHCRGIQLVVE---- 234
Query: 231 QNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEK 290
+ +VYN+G +T +E+ E + MG + V +G D ++ + +
Sbjct: 235 GGRPGEVYNIGGGTELTNRELTERLLAVMGAD--WSMVEQVPDRKG--HDRRYSVDITKI 290
Query: 291 AKKTGWRPKMNSYEAVRRTV 310
+ + G+RP++ E + RTV
Sbjct: 291 STELGYRPRVPFEEGLARTV 310
>pir||D75486 probable UDP-glucose 4-epimerase - Deinococcus radiodurans (strain
R1) >gi|6458415|gb|AAF10287.1|AE001927_6 (AE001927)
UDP-glucose 4-epimerase, putative [Deinococcus
radiodurans]
Length = 344
Score = 122 bits (302), Expect = 7e-27
Identities = 97/316 (30%), Positives = 154/316 (48%), Gaps = 19/316 (6%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLEN------ENFEFIRGD 56
V VTG GFIGSHL + L+ GY VR + ++ + WL+ E+ E GD
Sbjct: 19 VAVTGADGFIGSHLTEDLVRAGYRVRAMAIYNS---QGSYGWLDTVPGEVMEHVEVQLGD 75
Query: 57 MRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+RD V+ + DV+ V+HLAA + S +P ETN+ T N+L+A R+ ++
Sbjct: 76 VRDAGSVRALMRDVQTVYHLAALIAIPYSYVAPRSYVETNITGTLNVLEAARDLGTGRVI 135
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
TS+S VYG A +P ES+ PL+ S Y K+ A+ L Y FG + R N
Sbjct: 136 HTSTSEVYGTARSVPIHESH-PLQGQSPYSATKIGADKLAESYFLSFGLPVVTLRPFNTY 194
Query: 177 GKR-SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
G R S VI I++L E++ LGD + + + +V+DT + E +
Sbjct: 195 GPRQSARAVIPTIISQLAAGRTEIK-LGDLRPTRDFNYVADTARAFRAVGE--AGPEVLG 251
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK-- 293
N G+ I+V + +++++ MG + K D +G LL+ + +
Sbjct: 252 RTLNAGSGREISVGDTVKLIAQVMGKDVEVK---QEDERLRPEGSEVMRLLADHRELQTL 308
Query: 294 TGWRPKMNSYEAVRRT 309
TGW+P++ E ++RT
Sbjct: 309 TGWQPQVTLEEGLKRT 324
>gb|AAD50491.1|AF172324_9 (AF172324) UDP-Glc-4-epimerase GalE [Escherichia coli]
Length = 337
Score = 121 bits (300), Expect = 1e-26
Identities = 101/331 (30%), Positives = 155/331 (46%), Gaps = 33/331 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENFEFIRGDMR 58
MKVL+TGG G+IG H+ L++ G++V + D+LS L L R + + FIRGD+R
Sbjct: 1 MKVLLTGGLGYIGCHIAVELLQQGHDVVIFDNLSNSHLTVLERIKAITQKKVVFIRGDLR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+++ + +E V HLAA V S + P Y NV+ + NL+QA+ +N+K L+
Sbjct: 61 SLSDIRKTFESSQIEAVIHLAALKSVSESVRHPLEYYINNVVGSLNLIQAMSHANIKRLI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG---------YAHIFGFRA 167
F+SS+TVYG LP E + + YG KL E +++ + F
Sbjct: 121 FSSSATVYGQPEHLPITEQASVGKVTNPYGQTKLIIEKILADICLADPEWQITSLRYFNP 180
Query: 168 LIFRLANIIGK--RSNHGVIYDFINK--LKRNPNELEILG------DGKQRKSYLHVSDT 217
+ + +IG+ R I +I + ++R P ILG DG + Y+HV D
Sbjct: 181 IGAHPSGMIGEDPRGMPNNILPYITQVAIRRRP-YFTILGDDYPTKDGTGVRDYIHVQDL 239
Query: 218 INGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGW 277
G HI +NK + VYNLG +V +I E + F +
Sbjct: 240 ALG--HIAALMNAKNKSYQVYNLGTGKGYSVLDIINSFKEINNIDIPFIIE------KRR 291
Query: 278 KGDVKFMLLSIEKAKK-TGWRPKMNSYEAVR 307
GD+ S E AK+ GW+ K + +R
Sbjct: 292 PGDIAECWSSPELAKRELGWQAKFELKDMLR 322
>emb|CAB95930.1| (AL359989) UDP-glucose 4-epimerase [Streptomyces coelicolor A3(2)]
Length = 321
Score = 120 bits (298), Expect = 2e-26
Identities = 98/318 (30%), Positives = 148/318 (45%), Gaps = 43/318 (13%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
K LVTGGAG++GS + L+E G+EV VLD+LS G E + F+ GD+RD
Sbjct: 4 KYLVTGGAGYVGSVVAQHLVEAGHEVVVLDNLSTGFREGV-----PAGASFVEGDIRD-- 56
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
K + V H AA +V S PE ++ NV T LL+A+R + V+ LVF+S++
Sbjct: 57 AAKWLDGSFDGVLHFAAFSQVGESVVKPEKYWDNNVGGTMALLEAMRGAGVRRLVFSSTA 116
Query: 122 TVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSN 181
YG+ +P ES P P + YG +KLA + +I+G A G A+ R N+ G
Sbjct: 117 ATYGEPEQVPIVES-APTRPTNPYGASKLAVDHMITGEAAAHGLGAVSLRYFNVAGAYGE 175
Query: 182 HGVIYD--------FINKLKRNPNELEILG------DGKQRKSYLHVSDTINGILHIFEY 227
+G +D + + + + G DG + Y+HV+D H+
Sbjct: 176 YGERHDPESHLIPLVLQVAQGRREAISVYGDDYPTPDGTCVRDYIHVADLAEA--HLLAV 233
Query: 228 FKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMG------LSPKFKFTGGVDGGRGWKGDV 281
+ NLGN + +V+E+ E V G ++P+ RG GD
Sbjct: 234 AAAAPGEHLICNLGNGNGFSVREVVETVRRVTGHPIPEIMAPR----------RG--GDP 281
Query: 282 KFMLLSIEKAK-KTGWRP 298
++ S A+ K GW P
Sbjct: 282 AVLVASAGTAREKLGWNP 299
>dbj|BAB07083.1| (AP001518) spore coat polysaccharide synthesis (dTDP glucose 4,
6-dehydratase) [Bacillus halodurans]
Length = 321
Score = 120 bits (297), Expect = 3e-26
Identities = 87/315 (27%), Positives = 155/315 (48%), Gaps = 13/315 (4%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDG--YEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
++LVTGGAGFIGSH ++ L++ Y + +D L+ AG +EN++ + ++ N+ FI D+
Sbjct: 4 QILVTGGAGFIGSHFIEALLQHKPTYHITNVDVLTYAGKIENMSGFTKHPNYRFISADIG 63
Query: 59 DYKIVKEAVDDV-EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
D + A D +V+ H AA V S +P + ETN+L T+NLL A+ + K +++
Sbjct: 64 DADQLLGAFDRTYDVIVHFAAETHVDRSIHNPMVFLETNILGTHNLLLAVLKGYAKKILY 123
Query: 118 TSSSTVYGDANVLPTP-ESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S+ VYG + P PL + Y +K + L + + +I R +N
Sbjct: 124 ISTDEVYGSLGMKDVPFTEQSPLAANNPYSASKAGGDLLARSFYKTYQAPVIITRCSNNY 183
Query: 177 GKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFD 236
G R + + I ++ + GDG Q + +L+V+D + I E+ +I +
Sbjct: 184 GPRQDKEKLIPKIIANALTNKKIPLYGDGLQIRDWLYVTDHCRALTTIMEH----GEIGE 239
Query: 237 VYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGW 296
+YN+G + T EI + + +G V+ +G D ++ + + K+ GW
Sbjct: 240 IYNIGGGNERTNLEITKQILNILG--KDHDLINHVEDRKG--HDRRYAINWGKIHKQLGW 295
Query: 297 RPKMNSYEAVRRTVR 311
RP + + + TV+
Sbjct: 296 RPMVAFEDGLAETVQ 310
>gb|AAC68681.1| (AF079762) TDP-glucose-4,6-dehydratase [Streptomyces venezuelae]
Length = 337
Score = 119 bits (296), Expect = 4e-26
Identities = 92/318 (28%), Positives = 149/318 (45%), Gaps = 16/318 (5%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY------EVRVLDDLS-AGSLENLNRWLENENFEFI 53
M++LVTGGAGFIGSH V +L+ Y EV VLD L+ AG+ NL + F+
Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDADPRLRFV 60
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
GD+RD ++ + V+ + H AA V S + ETNV T LLQ ++ V
Sbjct: 61 HGDIRDAGLLARELRGVDAIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQCAVDAGVG 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+V S+ VYG + ES PLEP S Y +K ++ + Y +G I R
Sbjct: 121 RVVHVSTDEVYGSIDSGSWTES-SPLEPNSPYAASKAGSDLVARAYHRTYGLDVRITRCC 179
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
N G + + + L + GDG + ++H D GI + +
Sbjct: 180 NNYGPYQHPEKLIPLFVTNLLDGGTLPLYGDGANVREWVHTDDHCRGIALVL----AGGR 235
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK 293
++Y++G +T +E+ I+ + +G + V +G D+++ L E ++
Sbjct: 236 AGEIYHIGGGLELTNRELTGILLDSLGAD--WSSVRKVADRKG--HDLRYSLDGGEIERE 291
Query: 294 TGWRPKMNSYEAVRRTVR 311
G+RP+++ + + RTVR
Sbjct: 292 LGYRPQVSFADGLARTVR 309
>gb|AAD13546.1| (AF080235) NDP-hexose 4,6-dehydratase homolog [Streptomyces
cyanogenus]
Length = 326
Score = 119 bits (296), Expect = 4e-26
Identities = 94/318 (29%), Positives = 144/318 (44%), Gaps = 47/318 (14%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYE------VRVLDDLS-AGSLENLNRWLENENFEFIR 54
K+L+TGGAGFIGSH V L+ DGYE V VLD L+ AG+ +NL + F++
Sbjct: 3 KILITGGAGFIGSHYVRTLLNDGYEDWKGAHVTVLDKLTYAGNRDNLPE--AHPRLTFVQ 60
Query: 55 GDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
GD+ D++++ E + + V H AA V S +S E TNV T LL A+ + VK
Sbjct: 61 GDICDFELLLELLPGHDAVVHFAAESHVDRSLESAEEFVHTNVTGTQRLLDAVLATRVKR 120
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
+V S+ VYG + E + PL P S Y +K A++ L Y G I R +N
Sbjct: 121 VVHVSTDEVYGSIDEGSWTEEW-PLAPNSPYSASKAASDLLARSYWRTHGLDLSITRCSN 179
Query: 175 IIGKRSN-HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
G + +I F+ L ++ + GDG + +LHV D I + + +
Sbjct: 180 NYGPYQHPEKLIPLFVTNLLEG-EQVPLYGDGGNIREWLHVDDHCRAI----DLVLNKGR 234
Query: 234 IFDVYNLG------------------NEDWITVKEIAE-------------IVSEEMGLS 262
++YN+G +DW V+ + + + EE+G +
Sbjct: 235 AGEIYNIGGGNEQTNRAITERLIALTGQDWSKVRHVPDRKAHDLRYSLDESKIREELGYA 294
Query: 263 PKFKFTGGVDGGRGWKGD 280
P+ F G+ W D
Sbjct: 295 PRITFEQGLADTVAWYHD 312
>gb|AAC18831.1| (AF059755) nucleotide sugar epimerase [Vibrio vulnificus]
Length = 334
Score = 119 bits (295), Expect = 5e-26
Identities = 88/331 (26%), Positives = 151/331 (45%), Gaps = 27/331 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW----LENENFEFIRGD 56
MK LVTG AGFIGS ++L G+EV +D+L+ NL +EN F+F+ D
Sbjct: 1 MKYLVTGAAGFIGSATAEKLNAAGHEVVGIDNLNDYYDVNLKHARLARIENPLFKFVSVD 60
Query: 57 MRDYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+ D +++ A + + V HLAA VR S ++P ++N++ N+L+ R++ V
Sbjct: 61 ISDRGAMEQLFATEKFDRVIHLAAQAGVRYSLENPHAYADSNLVGHLNILEGCRQNKVSH 120
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
LV+ SSS+VYG +P S P+S+Y K + E + Y+H++ R
Sbjct: 121 LVYASSSSVYGLNAKVPFSTSDSVDHPVSLYAPTKKSNELMAHSYSHLYDIPTTGLRFFT 180
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
+ G + K + + ++I +G + + HV D + G++ I + +N+
Sbjct: 181 VYGSWGRPDMAPFIFTKKILDGDAIDINNNGDMWRDFTHVDDIVEGVVRIADVIPTRNES 240
Query: 235 --------------FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGD 280
+ VYN+G+ I + + + + E+G+ K F GD
Sbjct: 241 WTVEAGTPATSSAPYSVYNIGHGSPINLMDFVKAIENELGIEAKKNFR------EMQPGD 294
Query: 281 VKFMLLSIEKA-KKTGWRPKMNSYEAVRRTV 310
V E TG++P++ E V V
Sbjct: 295 VYQTYADTEDLFTATGYKPRVTVKEGVAEFV 325
>sp|P09609|GALX_KLULA GAL10 BIFUNCTIONAL PROTEIN [INCLUDES: UDP-GLUCOSE 4-EPIMERASE
(GALACTOWALDENASE); ALDOSE 1-EPIMERASE (MUTAROTASE)]
>gi|68389|pir||XUVKG UDPglucose 4-epimerase (EC 5.1.3.2)
- yeast (Kluyveromyces marxianus var. lactis)
>gi|2819|emb|CAA30090.1| (X07039) transferase (GAL10)
(AA 1 - 687) [Kluyveromyces lactis]
Length = 687
Score = 119 bits (295), Expect = 5e-26
Identities = 96/297 (32%), Positives = 146/297 (48%), Gaps = 30/297 (10%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENFEFIRGDMRDYK 61
LVTGGAG+IGSH V L E GY+ V+D+LS S E++ R L + +F + D+ + +
Sbjct: 8 LVTGGAGYIGSHTVVELCEAGYKCIVVDNLSNSSYESVARMELLTGQEIKFAKIDLCELE 67
Query: 62 IVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
+ + DD ++ V H A V S+Q P Y N++ T NLL+ ++ +VK LVF+S
Sbjct: 68 PLNKLFDDYKIDSVLHFAGLKAVGESTQIPLTYYFNNIVGTINLLECMKSHDVKKLVFSS 127
Query: 120 SSTVYGDA----NVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLAN 174
S+TVYGDA N++P PE+ P P + YG KL E ++ + F I R N
Sbjct: 128 SATVYGDATRFENMIPIPETC-PTGPTNPYGKTKLTIEDMMRDLHFSDKSFSFAILRYFN 186
Query: 175 IIGKRSNHGVIYDFIN------------KLKRNPNELEILG------DGKQRKSYLHVSD 216
IG + GVI + + R P +L + G DG + Y+HV D
Sbjct: 187 PIGAHPS-GVIGEAFGIPNNLLPFMAQVAIGRRP-KLYVFGDDYDSVDGTPIRDYIHVVD 244
Query: 217 TINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
G L +Y ++ +NLG TV ++ + +G + ++ T DG
Sbjct: 245 LAKGHLAALKYLEKYAGTCREWNLGTGHGTTVLQMYRAFCDAIGFNFEYVVTARRDG 301
>emb|CAA71250.1| (Y10168) glucose epimerase [Bacillus thuringiensis]
Length = 322
Score = 118 bits (294), Expect = 6e-26
Identities = 79/291 (27%), Positives = 140/291 (47%), Gaps = 26/291 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS-----AGSLENLNRWLENENFEFIRG 55
MK+LVTG AGFIG HL RL+ + V +D ++ + L + NF+F +
Sbjct: 4 MKILVTGAAGFIGFHLTKRLLAQNFHVIGVDSINDYYDVSLKKHRLKILEKKSNFKFYKI 63
Query: 56 DMRDYK----IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESN 111
D+ + + I KE + V +V +LAA VR S ++P+ +N++ N+L+A R+ N
Sbjct: 64 DISNKENLNQIFKEQI--VHIVINLAAQAGVRYSIENPDSYVNSNLVGFVNILEACRQYN 121
Query: 112 VKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFR 171
V+ L++ SSS+VYG +P P+S+Y K + E + Y+H+F R
Sbjct: 122 VEHLIYASSSSVYGANTSIPFSTKDSVDHPVSLYAATKKSNELMAHTYSHLFNIPTTGLR 181
Query: 172 LANIIGKRSNHGV-IYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIF----E 226
+ G + Y F + N + + +G R+ + ++ D I GI+ + +
Sbjct: 182 FFTVYGPWGRPDMAYYSFTRNIIIENNTIRVFNNGDMRRDFTYIDDIIEGIIRLIGNPPQ 241
Query: 227 YFKRQNKI----------FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF 267
Y ++ +K + +YN+GN I + + I+ + +G K +F
Sbjct: 242 YNEKWDKANPGLSSSYAPYKIYNIGNNIPIKLMDFIHILEKLIGKKAKIEF 292
>sp|P40801|GALX_PACTA GAL10 BIFUNCTIONAL PROTEIN [INCLUDES: UDP-GLUCOSE 4-EPIMERASE
(GALACTOWALDENASE); ALDOSE 1-EPIMERASE (MUTAROTASE)]
>gi|322912|pir||S29621 UDPglucose 4-epimerase (EC
5.1.3.2) - yeast (Pachysolen tannophilus)
>gi|3265|emb|CAA48580.1| (X68593) UDP-galactose-
4-epimerase [Pachysolen tannophilus]
Length = 689
Score = 118 bits (294), Expect = 6e-26
Identities = 94/299 (31%), Positives = 145/299 (48%), Gaps = 29/299 (9%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENFEFIRGDMRDY 60
+LVTGGAG+IGSH V L+ +GY V V+D+L S + + R L + F + D+ D+
Sbjct: 4 ILVTGGAGYIGSHTVVELVNNGYNVVVVDNLVNSSYDVIVRIEVLTRKQIPFFKIDLNDH 63
Query: 61 KIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ + ++ V H AA V S++ P Y NV +LL+ + E+NVK +VF+
Sbjct: 64 DALDQVFKLYPIQAVLHFAALKAVGESTKFPLNYYSNNVGGAISLLKVMEENNVKNIVFS 123
Query: 119 SSSTVYGDA----NVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLA 173
SS+TVYGDA N++P PE + P P + YG K+ E +I YA+ ++ I R
Sbjct: 124 SSATVYGDATRFENMIPIPE-HCPTGPTNPYGETKITIENIIRDVYANDKSWKCAILRYF 182
Query: 174 NIIGKRSNHGV----------IYDFINKLKRNPNE-LEILG------DGKQRKSYLHVSD 216
N IG + + + F+ ++ E L + G DG + Y+HV D
Sbjct: 183 NPIGAHPSGLIGEDPLGIPNNLLPFLAQVAIGRREKLSVFGSDYNSKDGTPIRDYIHVID 242
Query: 217 TINGILHIFEYF--KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
G + Y + N + +NLG + TV E+ E +G F+ G DG
Sbjct: 243 LAKGHIAALNYLFNHKDNGLCREWNLGTGNGSTVFEVFNAFCEAVGKKLPFEVVGRRDG 301
>dbj|BAA84593.1| (AB032523) dTDP-glucose 4,6-dehydratase [Streptomyces avermitilis]
Length = 355
Score = 118 bits (293), Expect = 8e-26
Identities = 96/316 (30%), Positives = 155/316 (48%), Gaps = 20/316 (6%)
Query: 5 VTGGAGFIGSHLVDRLMEDGY------EVRVLDDLS-AGSLENLNRWLENENFEFIRGDM 57
+TGGAGFIGSH V RL+ Y EV VLD L+ AG LENL L + + F+ GD+
Sbjct: 1 MTGGAGFIGSHFVRRLLTGAYPAFTGAEVVVLDKLTYAGRLENLAPVLGSPSLIFVHGDI 60
Query: 58 RDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
D +V + +D ++V H AA V S TNVL T+ LL+A ++ V V+
Sbjct: 61 CDGPLVADLMDGSDMVVHFAAESHVDRSVADAAEFVRTNVLGTHTLLRAATDAAVDRFVY 120
Query: 118 TSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
S+ VYG + E PLEP S Y +K +++ L + G +I R +N G
Sbjct: 121 ISTDEVYGSIDSGSWTED-APLEPNSPYSASKASSDLLARSFHRTHGLPVIITRCSNNYG 179
Query: 178 KRS-NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFD 236
+I F+ L N ++ + GDG+ + +LHV D GI + E + + +
Sbjct: 180 PHQFPEKLIPRFVTHL-LNGTKVPLYGDGENVRDWLHVDDHCRGIALVAE----RGRPGE 234
Query: 237 VYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEK-AKKTG 295
+Y++G ++ +E+ + + +G+ V+ KG + L I K + + G
Sbjct: 235 IYHIGGGTELSNRELTARLLDLLGVDWSM-----VEPVTDRKGHDRRYSLDISKISAELG 289
Query: 296 WRPKMNSYEAVRRTVR 311
+ P++ E + +TV+
Sbjct: 290 YAPRVPFEEGLAQTVQ 305
>pir||A75303 UDP-glucose 4-epimerase - Deinococcus radiodurans (strain R1)
>gi|6460005|gb|AAF11751.1|AE002053_6 (AE002053)
UDP-glucose 4-epimerase [Deinococcus radiodurans]
Length = 394
Score = 118 bits (292), Expect = 1e-25
Identities = 88/278 (31%), Positives = 131/278 (46%), Gaps = 24/278 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+LV GGAG+IGSH V +L G+EV V D+LS+G E L E IRGD+ D
Sbjct: 1 MKLLVVGGAGYIGSHTVRQLRAAGHEVAVFDNLSSGHAEALPG-----EVELIRGDLLDA 55
Query: 61 KIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
++ A++ + + H AA EV S ++P Y NV+ T NLLQ+I E+ LVF+
Sbjct: 56 ASIRAALEAQKPDAIIHFAALIEVGESMRAPGRYYRNNVVGTLNLLQSIVETRKVPLVFS 115
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ VYG + +P PE ++P SVYG K +E +I + G + R N+ G
Sbjct: 116 STAAVYGTTDAVPIPED-AAMQPESVYGETKRMSEQMIHAFHVAHGLPYTVLRYFNVCGA 174
Query: 179 RSNHGVIYDFINKLK----------RNPNELEILG------DGKQRKSYLHVSDTINGIL 222
+ NK ++ I G DG + Y+HV D + +
Sbjct: 175 APGGDIGEAHPNKTHLIELACLTALGQREKMMIFGDDYPTPDGTCIRDYVHVQDLADAHV 234
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMG 260
E YN+G +V+E+ + V +G
Sbjct: 235 LAVEALHAGKTDAATYNVGLGHGFSVREVLDAVDAVVG 272
>pir||F81317 UDPglucose 4-epimerase (EC 5.1.3.2) Cj1131c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968565|emb|CAB73386.1| (AL139077) UDP-glucose
4-epimerase [Campylobacter jejuni]
Length = 328
Score = 117 bits (290), Expect = 2e-25
Identities = 90/326 (27%), Positives = 155/326 (46%), Gaps = 29/326 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+L++GGAG+IGSH + + ++ +E+ VLD+LS GS + + F+F D+ D+
Sbjct: 1 MKILISGGAGYIGSHTLRQFLKTDHEICVLDNLSKGSKIAIEDLQKTRAFKFFEQDLSDF 60
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ VK + + + H AA+ EV S Q+P Y N + T NL++ ++ V +F+
Sbjct: 61 QGVKALFEREKFDAIVHFAASIEVFESMQNPLKYYMNNTVNTTNLIETCLQTGVNKFIFS 120
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANIIG 177
S++ YG+ P PL PI+ YG +KL +E ++ + F+ I R N+ G
Sbjct: 121 STAATYGEPQT-PVVSETSPLAPINPYGRSKLMSEEVLRDASMANPEFKHCILRYFNVAG 179
Query: 178 KRSNH--GVIYDFINKLKR--------NPNELEILG------DGKQRKSYLHVSDTINGI 221
++ G Y L + ++L I G DG + ++HV D +
Sbjct: 180 ACMDYTLGQRYPKATLLIKVAAECAAGKRDKLFIFGDDYDTKDGTCIRDFIHVDDISSAH 239
Query: 222 LHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDV 281
L +Y K +V+N+G +VKE+ E + + G+ K V+ GD
Sbjct: 240 LAALDYLKENES--NVFNVGYGHGFSVKEVIEAMKKVSGVDFK------VELAPRRAGDP 291
Query: 282 KFMLLSIEKAKK-TGWRPKMNSYEAV 306
++ K + T W+PK + E +
Sbjct: 292 SVLISDASKIRNLTSWQPKYDDLELI 317
>gb|AAG18703.1| (AE004975) GDP-D-mannose dehydratase; Gmd [Halobacterium sp. NRC-1]
Length = 309
Score = 117 bits (290), Expect = 2e-25
Identities = 90/315 (28%), Positives = 150/315 (47%), Gaps = 22/315 (6%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKIV 63
LVTG AGFIGSHL L++ GY+VR +D+ + G +NL +F F D+RD +V
Sbjct: 5 LVTGVAGFIGSHLAAALLDRGYDVRGVDNFATGHDQNLEPLRGTGDFSFYEADIRDADLV 64
Query: 64 KEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSSTV 123
+ + V+ VFH AA+ V S + P + N T ++ A RE++V +V SS+ +
Sbjct: 65 ADVTNGVDYVFHQAADSSVPRSVEDPVTTTDVNCTGTATVIDAAREADVDTVVVASSAAI 124
Query: 124 YGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSN-- 181
YG P ES +P S Y +K E L + ++ R NI G R +
Sbjct: 125 YGSTETFPKVESMTE-QPESPYALSKHYTEKLALQASELYDIDTAALRYFNIYGPRQDPN 183
Query: 182 ---HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVY 238
VI FI+ L + I GDG+Q + + + + I + E + + +
Sbjct: 184 GDYAAVIPKFIS-LMLDGERPVIYGDGEQSRDFTFIDNAIQANIRAAE----GDVTGEAF 238
Query: 239 NLGNEDWITVKEIAEIVSE--EMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK-TG 295
N+G +TV E+ +++++ + + P + D R GDV+ I KA++
Sbjct: 239 NVGCGGRVTVNELVDVLNDLLDTDIDPIY------DDPR--PGDVRHSHADISKARELLS 290
Query: 296 WRPKMNSYEAVRRTV 310
+ P++ E + +T+
Sbjct: 291 YEPEVGFSEGLEQTI 305
>pir||A70392 UDP-glucose-4-epimerase - Aquifex aeolicus
>gi|2983546|gb|AAC07120.1| (AE000721)
UDP-glucose-4-epimerase [Aquifex aeolicus]
Length = 327
Score = 116 bits (289), Expect = 2e-25
Identities = 103/331 (31%), Positives = 150/331 (45%), Gaps = 34/331 (10%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
KVLVTGGAG+IGSH+V L E GYEV + D+LS G N W + ++ D+ D +
Sbjct: 3 KVLVTGGAGYIGSHVVKALGEKGYEVLIYDNLSTG-----NEWAVLYG-KLVKADLADKE 56
Query: 62 IVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++ ++ + V H AA V S + P Y NV+ T NLL+ ++E V VF+S
Sbjct: 57 TLRRVFEEFKPDAVMHFAAYIVVPESVKEPLKYYRNNVVNTINLLEVMQEFGVNKFVFSS 116
Query: 120 SSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHI-FGFRALIFRLANIIG- 177
S+ VYG +P E PL PI+ YG K E ++ + F + R N+ G
Sbjct: 117 SAAVYGIPESIPVKED-APLNPINPYGETKATVERILRDLKNSGKDFNYVSLRYFNVAGA 175
Query: 178 -KRSNHGVIYD-----FINKLKRNPNE---LEILG------DGKQRKSYLHVSDTINGIL 222
G Y I +K E LEI G DG + Y+HV+D +
Sbjct: 176 DPEGKIGFAYPNPTHLIIRAVKTAAGEFDRLEIYGTDYPTPDGTCIRDYIHVTDLAEAHI 235
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVK 282
EY K +V N G +V E+ V + G+ K V+ R +GD
Sbjct: 236 LALEYLFSGGK-SEVLNCGYGHGYSVLEVVNAVKKVTGVDFKV-----VEAPRR-EGDPP 288
Query: 283 FMLLSIEKAKKT-GWRPKMNSYEAVRRTVRE 312
++ +K K+ W PK + E + +T E
Sbjct: 289 ALVADNKKIKRVLNWEPKYDDLEFIIKTAWE 319
>emb|CAA72350.1| (Y11648) galE [Campylobacter jejuni]
Length = 328
Score = 116 bits (289), Expect = 2e-25
Identities = 90/319 (28%), Positives = 151/319 (47%), Gaps = 29/319 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+L++GGAG+IGSH + + ++ +E+ VLD+LS GS + + F+F D+ D+
Sbjct: 1 MKILISGGAGYIGSHTLRQFLKTDHEICVLDNLSKGSKIAIEDLQKIRTFKFFEQDLSDF 60
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ VK + + + H AA+ EV S Q+P Y N + T NL++ ++ V +F+
Sbjct: 61 QGVKALFEREKFDAIVHFAASIEVFESMQNPLKYYMNNTVNTTNLIETCLQTGVNKFIFS 120
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANIIG 177
S++ YG+ P PL PI+ YG +KL +E ++ + F+ I R N+ G
Sbjct: 121 STAATYGEPQT-PVVSETSPLAPINPYGRSKLMSEEVLRDASMANPEFKHCILRYFNVAG 179
Query: 178 KRSNH--GVIYDFINKL--------KRNPNELEILG------DGKQRKSYLHVSDTINGI 221
++ G Y L N+L I G DG + ++HV D +
Sbjct: 180 ACMDYTLGQRYPKATLLIKVAAECAAEKRNKLFIFGDDYDTKDGTCIRDFIHVDDISSAH 239
Query: 222 LHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDV 281
L +Y K +V+N+G +VKE+ E + + G+ K V+ GD
Sbjct: 240 LSALDYLKENES--NVFNVGYGHGFSVKEVIEAMKKVSGVDFK------VELAPRRAGDP 291
Query: 282 KFMLLSIEKAKK-TGWRPK 299
++ K + T W+PK
Sbjct: 292 SVLISDASKIRNLTSWQPK 310
>emb|CAC01389.1| (AJ131360) UDP-glucose 4-epimease [Campylobacter jejuni]
Length = 330
Score = 116 bits (289), Expect = 2e-25
Identities = 90/319 (28%), Positives = 151/319 (47%), Gaps = 29/319 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+L++GGAG+IGSH + + ++ +E+ VLD+LS GS + + F+F D+ D+
Sbjct: 3 MKILISGGAGYIGSHTLRQFLKTDHEICVLDNLSKGSKIAIEDLQKIRTFKFFEQDLSDF 62
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ VK + + + H AA+ EV S Q+P Y N + T NL++ ++ V +F+
Sbjct: 63 QGVKALFEREKFDAIVHFAASIEVFESMQNPLKYYMNNTVNTTNLIETCLQTGVNKFIFS 122
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANIIG 177
S++ YG+ P PL PI+ YG +KL +E ++ + F+ I R N+ G
Sbjct: 123 STAATYGEPQT-PVVSETSPLAPINPYGRSKLMSEEVLRDASMANPEFKHCILRYFNVAG 181
Query: 178 KRSNH--GVIYDFINKL--------KRNPNELEILG------DGKQRKSYLHVSDTINGI 221
++ G Y L N+L I G DG + ++HV D +
Sbjct: 182 ACMDYTLGQRYPKATLLIKVAAECAAEKRNKLFIFGDDYDTKDGTCIRDFIHVDDISSAH 241
Query: 222 LHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDV 281
L +Y K +V+N+G +VKE+ E + + G+ K V+ GD
Sbjct: 242 LSALDYLKENES--NVFNVGYGHGFSVKEVIEAMKKVSGVDFK------VELAPRRAGDP 293
Query: 282 KFMLLSIEKAKK-TGWRPK 299
++ K + T W+PK
Sbjct: 294 SVLISDASKIRNLTSWQPK 312
>gb|AAB48319.1| (U29691) CDP-tyvelose epimerase [Yersinia pseudotuberculosis]
Length = 338
Score = 116 bits (288), Expect = 3e-25
Identities = 99/338 (29%), Positives = 169/338 (49%), Gaps = 40/338 (11%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSA-GSLENLNRWLEN-ENFEFIRGDMR 58
MK+L+TGG GF+GS+L ++ G EV V D+LS GS +NL +WL++ F ++ GD+R
Sbjct: 1 MKLLITGGCGFLGSNLASHAIKSGMEVIVFDNLSRYGSSDNL-KWLQSIGGFTYVHGDIR 59
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF-L 115
+ + + + +FHLA + S +P++ +E NV T+NLL+AIR N + +
Sbjct: 60 NRNDITRLIQKFKPDSIFHLAGQVAMTTSIDNPQMDFEVNVGGTFNLLEAIRLFNPECGI 119
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPI---------------SVYGGAKLAAEALISGYA 160
+++S++ VYGD E+ E I S YG +K AA+ + YA
Sbjct: 120 IYSSTNKVYGDLEQFTYRETDTRYECIEMPDGFDESTQLTFHSPYGCSKGAADQYMLDYA 179
Query: 161 HIFGFRALIFRLANIIGKRS----NHGVIYDFINK---LKRNPNE-LEILGDGKQRKSYL 212
I+G + ++FR +++ G R + G + F K R N I G+GKQ + L
Sbjct: 180 RIYGLKTVVFRHSSMYGGRQFSTYDQGWVGWFCQKAIEASRGVNSPFAISGNGKQVRDVL 239
Query: 213 HVSDTINGILHIFEYFKRQNKIFDVYNLGN--EDWITVKEIAEIVSEEMGLSPKFKFTGG 270
H D I+ +R + +N+G E +++ E+ ++ E + K+T
Sbjct: 240 HAEDIISLYFSTLSNLERVKG--NAFNIGGTIEHSLSLLELFSLL--EKYTETELKYTRI 295
Query: 271 VDGGRGWKGDVKFMLLSIEK-AKKTGWRPKMNSYEAVR 307
+ D K + +I K ++ TGW PK++S ++
Sbjct: 296 PVR----ESDQKVFVANINKISESTGWIPKVSSESGIK 329
>pir||C75597 thymidine diphosphoglucose 4,6-dehydratase - Deinococcus
radiodurans (strain R1)
>gi|6460562|gb|AAF12268.1|AE001862_94 (AE001862)
thymidine diphosphoglucose 4,6-dehydratase [Deinococcus
radiodurans]
Length = 364
Score = 115 bits (285), Expect = 7e-25
Identities = 99/316 (31%), Positives = 148/316 (46%), Gaps = 19/316 (6%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVL--DDLS-AGSLENLNRWLENENFEFIRGDMRD 59
+LVTGG GFIGS+ V + E +V+ D L+ AG ENL+ +N + GD+ D
Sbjct: 16 LLVTGGCGFIGSNFVRYWLGQHPESKVVVYDKLTYAGRKENLHDLWDNPALSLVVGDIGD 75
Query: 60 YKIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
+V+ +DV+++ + AA V S P + ETNV T+ LL+ RE ++ L
Sbjct: 76 MDLVRRTCQENDVDLIVNFAAETHVDQSILGPLVFTETNVRGTHVLLEVARELGIR-LHH 134
Query: 118 TSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
S+ VYG L P S Y +K AA+ L+ YA +G I R AN +G
Sbjct: 135 ISTDEVYGHIKDGHQSVETDELAPRSPYAASKAAADQLVQAYAITYGIPVTITRGANNVG 194
Query: 178 --KRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
+ V N + P L + GDG+Q + Y HV D GI E + I
Sbjct: 195 PYQYPEKAVPLFSTNAILGEP--LPVYGDGQQMRDYAHVYDHCTGI----ETVLLRGNIG 248
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTG 295
+VYN+G +T E+ +IV E +G K V G + ++++K + G
Sbjct: 249 EVYNVGTGREMTNLEMVDIVLETLG-----KDHSLVKHVTDRPGHDRRYSMNVDKLRSLG 303
Query: 296 WRPKMNSYEAVRRTVR 311
W+PK + +AV R
Sbjct: 304 WQPKYDPKQAVAEAAR 319
>sp|P21977|GALE_STRTR UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|280223|pir||A44509 UDPglucose
4-epimerase (EC 5.1.3.2) - Streptococcus thermophilus
>gi|153749|gb|AAA26944.1| (M38175) UDPglucose
4-epimerase [Streptococcus thermophilus]
Length = 332
Score = 114 bits (282), Expect = 2e-24
Identities = 94/327 (28%), Positives = 152/327 (45%), Gaps = 35/327 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE-VRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
M +LV GGAG+IGSH+VDRL+E G E V V+D L G +R + + F +GD+ D
Sbjct: 1 MAILVLGGAGYIGSHMVDRLVEKGQEKVVVVDSLVTG-----HRAAVHPDAIFYQGDLSD 55
Query: 60 Y----KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
K+ KE DV+ V H AA V S + P ++ N LL+ + E VK++
Sbjct: 56 QDFMRKVFKEN-PDVDAVIHFAAYSLVGESMEKPLKYFDNNTAGMVKLLEVMNECGVKYI 114
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
VF+S++ YG +P E+ P PI+ YG +KL E ++ +G + + R N+
Sbjct: 115 VFSSTAATYGIPEEIPILET-TPQNPINPYGESKLMMETIMKWSDQAYGIKYVPLRYFNV 173
Query: 176 IG---------KRSNHGVIYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTING 220
G RS ++ + + ++ I G DG + Y+H D +
Sbjct: 174 AGANLMVRLVRTRSETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADA 233
Query: 221 ILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGD 280
L EY ++ N+ +NLG+ + +I E + G + GD
Sbjct: 234 HLLAVEYLRKGNE-STAFNLGSSTGFSNLQILEAARKVTGKEIP------AEKADRRPGD 286
Query: 281 VKFMLLSIEKAKKT-GWRPKMNSYEAV 306
++ S EKA+ GW+P+ ++ E +
Sbjct: 287 PDILIASSEKARTVLGWKPQFDNIEKI 313
>sp|P39630|SPSJ_BACSU SPORE COAT POLYSACCHARIDE BIOSYNTHESIS PROTEIN SPSJ
>gi|629079|pir||S39727 dTDPglucose 4,6-dehydratase (EC
4.2.1.46) spsJ - Bacillus subtilis
>gi|413996|emb|CAA51628.1| (X73124) ipa-72d [Bacillus
subtilis] >gi|2636318|emb|CAB15809.1| (Z99123) alternate
gene name: ipa-72d [Bacillus subtilis]
Length = 315
Score = 114 bits (282), Expect = 2e-24
Identities = 86/312 (27%), Positives = 145/312 (45%), Gaps = 13/312 (4%)
Query: 4 LVTGGAGFIGSHLVDRLM-EDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRDYK 61
L+TGGAGFIG ++ E + VLD L+ A E + + +N F F++GD+ +
Sbjct: 6 LITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEEMEKLKQNSRFRFVKGDISVQE 65
Query: 62 IVKEAVDDV-EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ A D+ + V H AA V S E TNV+ TY L +A+ + K L+ S+
Sbjct: 66 DIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNVMGTYRLAEAVLKGKAKKLIHIST 125
Query: 121 STVYGDANV-LPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKR 179
VYGD P PL P + Y +K +++ L+ Y A+I R +N G
Sbjct: 126 DEVYGDLKADDPAFTETTPLSPNNPYSASKASSDLLVLSYVKTHKLPAIITRCSNNYGPY 185
Query: 180 SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYN 239
+ + I + + + + GDG Q + +L D I I E + +VYN
Sbjct: 186 QHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWLFAEDHCRAIKLILE----KGTDGEVYN 241
Query: 240 LGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPK 299
+G + T KE+A ++ + +G F V+ +G D ++ + + + + GWR +
Sbjct: 242 IGGGNERTNKELASVILKHLGCEELF---AHVEDRKG--HDRRYAINASKLKNELGWRQE 296
Query: 300 MNSYEAVRRTVR 311
+ E + RT++
Sbjct: 297 VTFEEGIARTIQ 308
>sp|P39858|CAPI_STAAU CAPI PROTEIN >gi|506705|gb|AAA64648.1| (U10927) CapI
[Staphylococcus aureus]
Length = 334
Score = 113 bits (281), Expect = 2e-24
Identities = 76/280 (27%), Positives = 131/280 (46%), Gaps = 20/280 (7%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL----SAGSLENLNRWLENENFEFIRGD 56
MK+L+TG AGFIGSHL +L++ G+ V +D + S E+ + + ENF F +
Sbjct: 1 MKILITGTAGFIGSHLAKKLIKQGHYVIGVDSINDYYSVSLKEDRLKSIGKENFTFNKVK 60
Query: 57 MRDYK-IVKEAVDDV-EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+ +Y + K VD+ EVV +LAA VR S ++P ++N++ N+L+ R N++
Sbjct: 61 LENYDDLSKVFVDEQPEVVVNLAAQAGVRYSIENPRTYIDSNIVGFMNILECSRHFNIQN 120
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
L++ SSS+VYG P S P+S+Y K + E + Y+H++ R
Sbjct: 121 LIYASSSSVYGANTSKPFSTSDNIDHPLSLYAATKKSNELMAHTYSHLYNLPTTGLRFFT 180
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK- 233
+ G + K N +++ G + + +V D + I + + NK
Sbjct: 181 VYGPWGRPDMALFKFTKAIVNDQAIDVYNHGNMMRDFTYVDDIVEAISRLVKKPASPNKE 240
Query: 234 -------------IFDVYNLGNEDWITVKEIAEIVSEEMG 260
+ VYN+GN + + E E + ++G
Sbjct: 241 WSGADPDPGSSYAPYKVYNIGNNSPVRLMEFVEAIENKLG 280
>gi|6319493 UDP-glucose 4-epimerase; Gal10p [Saccharomyces cerevisiae]
>gi|585169|sp|P04397|GALX_YEAST GAL10 BIFUNCTIONAL
PROTEIN [INCLUDES: UDP-GLUCOSE 4-EPIMERASE
(GALACTOWALDENASE); ALDOSE 1-EPIMERASE (MUTAROTASE)]
>gi|625246|pir||XEBYUG UDPglucose 4-epimerase (EC
5.1.3.2) - yeast (Saccharomyces cerevisiae)
>gi|536222|emb|CAA84961.1| (Z35888) ORF YBR019c
[Saccharomyces cerevisiae]
Length = 699
Score = 113 bits (281), Expect = 2e-24
Identities = 94/298 (31%), Positives = 146/298 (48%), Gaps = 33/298 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENFEFIRGDMRDY 60
VLVTGGAG+IGSH V L+E+GY+ V D+LS + +++ R L + F D+ D
Sbjct: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73
Query: 61 KIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
K +++ + ++ V H A V S+Q P Y N+L T LL+ +++ NV VF+
Sbjct: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS 133
Query: 119 SSSTVYGDA----NVLPTPESYGPLEPISVYGGAKLAAEALISGY--AHIFGFRALIFRL 172
SS+TVYGDA N++P PE PL P + YG K A E +++ + ++ I R
Sbjct: 134 SSATVYGDATRFPNMIPIPEEC-PLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILRY 192
Query: 173 ANIIGKRSNHGVIYDFINKLKRN------------PNELEILG------DGKQRKSYLHV 214
N IG + G+I + + N +L I G DG + Y+HV
Sbjct: 193 FNPIGAHPS-GLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHV 251
Query: 215 SDTINGILHIFEYFKRQNK---IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTG 269
D G + +Y + N+ + +NLG+ TV E+ + G+ +K TG
Sbjct: 252 VDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTG 309
>pir||T48867 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated] -
Streptomyces argillaceus >gi|1814005|emb|CAA71847.1|
(Y10907) TDP-D-Glucose-4,6,-dehydratase [Streptomyces
argillaceus] >gi|3334820|emb|CAA07755.1| (AJ007932)
dTDP-glucose 4,6-dehydratase [Streptomyces argillaceus]
Length = 331
Score = 113 bits (281), Expect = 2e-24
Identities = 91/315 (28%), Positives = 147/315 (45%), Gaps = 18/315 (5%)
Query: 3 VLVTGGAGFIGSHLVDRLMED----GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDM 57
+LVTGGAGFIGSH V L+ V VLD L+ AG+L NL +++ F F+RGD+
Sbjct: 6 ILVTGGAGFIGSHYVRTLLGPRGVPDVTVTVLDKLTYAGTLTNLAEVSDSDRFRFVRGDI 65
Query: 58 RDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
D +V + + + V H AA V S TNV T LL A ++ V
Sbjct: 66 CDAPLVDDLLAVHDQVVHFAAESHVDRSILGAADFVRTNVTGTQTLLDAALRQGIETFVH 125
Query: 118 TSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
S+ VYG + PE+ P+ P S+Y AK +++ + Y G + R +N G
Sbjct: 126 ISTDEVYGSIDAGSWPET-APVSPNSLYSAAKASSDLVALAYHRTHGLDVRVTRCSNNYG 184
Query: 178 KRS-NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFD 236
VI F+ L + E+ + GDG + +LHV D + I E + + +
Sbjct: 185 SHQFPEKVIPLFVTSL-LDGREVPLYGDGTNVRDWLHVDDHVRAI----ELVRTGGRAGE 239
Query: 237 VYNLGNEDWITVKEIAEIVSEEMGLS-PKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTG 295
VYN+G ++ KE+ +++ + G + ++ G D ++ + + ++ G
Sbjct: 240 VYNIGGGTELSNKELTQLLLDACGAGWDRVRYVTDRKG-----HDRRYSVDCTKIRRELG 294
Query: 296 WRPKMNSYEAVRRTV 310
+RP +A+ TV
Sbjct: 295 YRPAREFGDALAETV 309
>pir||C81288 probable sugar-nucleotide epimerase/dehydratease Cj1427c [imported]
- Campylobacter jejuni (strain NCTC 11168)
>gi|6968856|emb|CAB73851.1| (AL139078) putative
sugar-nucleotide epimerase/dehydratease [Campylobacter
jejuni]
Length = 313
Score = 113 bits (281), Expect = 2e-24
Identities = 89/314 (28%), Positives = 151/314 (47%), Gaps = 22/314 (7%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
KVL+TGGAG+IGS L L+E GYEV V+D+L + L+ N+NF FI GD D
Sbjct: 4 KVLITGGAGYIGSVLTPILLEKGYEVCVIDNLMFDQISLLS-CFHNKNFTFINGDAMDEN 62
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
++++ V +++ LAA + ++P+L N + S + T+S
Sbjct: 63 LIRQEVAKADIIIPLAALVGAPLCKRNPKLAKMINYEAVKMISDFASPSQIFIYPNTNSG 122
Query: 122 TVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG---K 178
G+ + + T ES PL PIS YG K+ AE + + + FRLA + G +
Sbjct: 123 YGIGEKDAMCTEES--PLRPISEYGIDKVHAEQYLLDKGN-----CVTFRLATVFGISPR 175
Query: 179 RSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVY 238
++ DF + R ++ +L + R++Y+HV D + G +H E + + Y
Sbjct: 176 MRLDLLVNDFTYRAYR--DKFIVLFEEHFRRNYIHVRDVVKGFIHGIENYDKMKG--QAY 231
Query: 239 NLG-NEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWR 297
N+G + +T +++AE + + + P F G D + L+S K + TGW+
Sbjct: 232 NMGLSSANLTKRQLAETIKKYI---PDFYIH---SANIGEDPDKRDYLVSNTKLEATGWK 285
Query: 298 PKMNSYEAVRRTVR 311
P + ++ +R
Sbjct: 286 PDNTLEDGIKELLR 299
>pir||G82785 dTDP-glucose 4-6-dehydratase XF0611 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9105480|gb|AAF83421.1|AE003906_10
(AE003906) dTDP-glucose 4-6-dehydratase [Xylella
fastidiosa]
Length = 329
Score = 113 bits (280), Expect = 3e-24
Identities = 94/317 (29%), Positives = 153/317 (47%), Gaps = 24/317 (7%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
+VLVTGGAGF+GSHL ++L+ G++V +D+ GS +++ + + FE IR D+
Sbjct: 22 RVLVTGGAGFLGSHLCEKLVASGHDVLCVDNFYTGSKDSVINLIGHPKFELIRHDVTFPL 81
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
V +V+ +++LA P +T+V N+L + + L S+S
Sbjct: 82 YV-----EVDRIYNLACPASPVHYQHDPVQTTKTSVHGAINMLGLAKRVKARILQ-ASTS 135
Query: 122 TVYGDANVLPTPESY-GPLEPI---SVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
VYGD + P E+Y G + P+ S Y K AE L Y + R+ N G
Sbjct: 136 EVYGDPEIHPQLETYWGRVNPVGIRSCYDEGKRCAETLFFDYWRQHKLEIKVTRIFNTYG 195
Query: 178 KR--SNHG-VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
R N G V+ +FI + R + I GDG Q +S+ +V D I+G+L + E K N
Sbjct: 196 PRMHPNDGRVVSNFIVQALRG-EPITIYGDGTQTRSFCYVDDLIDGMLRMMESPKDFN-- 252
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTG-GVDGGRGWKGDVKFMLLSIEKAKK 293
N+GN T+ ++AE+V + +G K F +D + + D+ +
Sbjct: 253 -GPVNIGNPTEFTMLQLAEMVLKLVGSISKIVFQPLPLDDPKQRQPDITL------AKSQ 305
Query: 294 TGWRPKMNSYEAVRRTV 310
GW PK++ + +R T+
Sbjct: 306 LGWEPKVSLEDGLRETI 322
>gb|AAG02361.1|AF210249_20 (AF210249) sugar epimerase BlmG [Streptomyces verticillus]
Length = 325
Score = 113 bits (280), Expect = 3e-24
Identities = 90/322 (27%), Positives = 148/322 (45%), Gaps = 34/322 (10%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKIV 63
+VTG GFIGSHLV RL+ DG+ VR +D + R+ E EF+ D+RD
Sbjct: 5 VVTGAGGFIGSHLVRRLVRDGHRVRGVDLVPP-------RYGPGEAQEFVIADLRDAAQA 57
Query: 64 KEAVDDVEVVFHLAAN-PEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSST 122
AV + VF LAAN + + +P + N+LI+ + ++A R + V+ V+TSS+
Sbjct: 58 ARAVAGADSVFALAANMGGIGWTHTAPAEILHDNLLISTHTIEACRAAGVRTTVYTSSAC 117
Query: 123 VY-----GDANVLPTPES-YGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
VY + + P E P EP YG KL E L Y G RL I
Sbjct: 118 VYPASLQREPDAAPLAEDPVFPAEPDMEYGWEKLTTEILCGAYRRSHGMDIKTARLHAIY 177
Query: 177 G--------KRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYF 228
G + + ++ D + ++ + E+E+ GDG Q +SY +V D + G++ +
Sbjct: 178 GPLGTYTGPRAKSLSMLCDKVARIPGDEGEIEVWGDGTQTRSYCYVDDCVEGLIRL---- 233
Query: 229 KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVD-GGRGWKGDVKFMLLS 287
++ + + N+G+E+ + + + E ++ G + F G RG D +
Sbjct: 234 -ARSDVAEPVNIGSEERVDIASLVERIAGVAGKKVRCAFAPDRPVGPRGRVSD------N 286
Query: 288 IEKAKKTGWRPKMNSYEAVRRT 309
+ GW P+ + + RT
Sbjct: 287 TRCRELLGWAPETSLAAGLERT 308
>sp|P96995|GALE_STRMU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437233|pir||JC5313 UDPglucose
4-epimerase (EC 5.1.3.2) - Streptococcus mutans
>gi|1877424|gb|AAB49738.1| (U21942) UDP-galactose
4-epimerase [Streptococcus mutans]
Length = 333
Score = 113 bits (279), Expect = 4e-24
Identities = 91/327 (27%), Positives = 147/327 (44%), Gaps = 34/327 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE-VRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
M +LV GGAG+IGSH+VDRL+E G E V V+D L G +R + +F +GD+ D
Sbjct: 1 MAILVLGGAGYIGSHMVDRLIEKGEEEVVVVDSLVTG-----HRAAVHPAAKFYQGDLAD 55
Query: 60 YKIVKEAV---DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ + DV+ V H AA V S + P ++ N LL+ + E VK++V
Sbjct: 56 REFMSMVFRENPDVDAVIHFAAYSLVAESMKKPLKYFDNNTAGMIKLLEVMSEFGVKYIV 115
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
F+S++ YG N +P E+ P PI+ YG +KL E ++ +G + + R N+
Sbjct: 116 FSSTAATYGIPNEIPIKET-TPQRPINPYGESKLMMETIMKWSDRAYGIKFVPVRYFNVA 174
Query: 177 GKRSNHGVIYDFINKLKRNPNELEI----------------LGDGKQRKSYLHVSDTING 220
G + + + D + P L++ DG + Y+H D +
Sbjct: 175 GAKPDGSIGEDHSPETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADR 234
Query: 221 ILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGD 280
L Y RQ +NLG+ + +I E + G + GD
Sbjct: 235 HLLALNYL-RQGNPSTAFNLGSSTGFSNLQILEAARKVTGQKIP------AEKAARRSGD 287
Query: 281 VKFMLLSIEKAKK-TGWRPKMNSYEAV 306
++ S EKA++ GW+P+ + E +
Sbjct: 288 PDTLIASSEKAREVVGWKPQFDDIEKI 314
>gb|AAF00211.1|AF164960_7 (AF164960) dNDP-glucose 4,6-dehydratase [Streptomyces fradiae]
Length = 328
Score = 113 bits (279), Expect = 4e-24
Identities = 93/318 (29%), Positives = 148/318 (46%), Gaps = 20/318 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE------VRVLDDLS-AGSLENLNRWLENENFEFI 53
M +LVTG AGFIGSH V L+ D Y V LD L+ AG+ NL N EF+
Sbjct: 1 MNILVTGAAGFIGSHFVRSLLADTYSGWEGARVTALDKLTYAGNRNNLPP--SNPRLEFV 58
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
RGD+ D +++E + V H AA V S + + TNVL T LL A+ +S V+
Sbjct: 59 RGDVCDRALLRELLPGHHAVVHFAAESHVDRSLEGAGEFFRTNVLGTQTLLDAVLDSGVE 118
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+V S+ VYG E + PL+P S Y +K ++ + Y I R +
Sbjct: 119 RVVHVSTDEVYGSIEQGSWTEDW-PLQPNSPYAASKACSDLVARAYCAPTEVDLSITRCS 177
Query: 174 NIIGKRSN-HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
N G + VI F+ L ++ + GDG+ + +LHV D GI + +
Sbjct: 178 NNYGPHQHPEKVIPRFVTNLLEG-RQVPLYGDGRNVREWLHVEDHCRGIHLVL----NKG 232
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAK 292
+ ++YN+G + T + E + E G P + V + D+++ + + +
Sbjct: 233 QAGEIYNIGGGNEYTNLALTEKLLELTGAGP--EMIRRVPDRKA--HDLRYSIDESKIRE 288
Query: 293 KTGWRPKMNSYEAVRRTV 310
K G+ P+++ + + TV
Sbjct: 289 KLGYAPRISFEQGLSDTV 306
>pir||G83471 UDP-glucose 4-epimerase PA1384 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9947329|gb|AAG04773.1|AE004568_2
(AE004568) UDP-glucose 4-epimerase [Pseudomonas
aeruginosa]
Length = 337
Score = 113 bits (279), Expect = 4e-24
Identities = 107/325 (32%), Positives = 152/325 (45%), Gaps = 40/325 (12%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENFEFIRGDMR 58
M+VLVTGGAGFIGSH++ L+ G +V VLD+L GS E+L R + F+ GD+R
Sbjct: 1 MRVLVTGGAGFIGSHVLVELLGQGAKVVVLDNLVNGSSESLKRVERITGHPVGFVLGDVR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D +V+ + D V+ V HLA V S P YE+NV T +LL+A++ V +V
Sbjct: 61 DSLLVERLLIDEKVDAVIHLAGLKAVGESVDDPLEYYESNVQGTISLLRAMQRVGVFKIV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHI-FGFRALIFRLANI 175
F+SS+T+Y LP ES S YG KL AE ++ A + + R N
Sbjct: 121 FSSSATIYQMPGTLPISESSKVGGVASPYGRTKLTAEHMLDDLARSDTRWSIAVLRYFNP 180
Query: 176 IGKRSNHGVIYD----------------FINKLKRNPNELEILG------DGKQRKSYLH 213
IG + G+I + + +L R L + G DG + Y+H
Sbjct: 181 IGAHES-GLIGEDPCGTPNNLLPYIAQVAVGRLSR----LTVHGGDYPTIDGTGVRDYIH 235
Query: 214 VSDTINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
V D G EY Q + V+NLG +V ++ E G + FT V G
Sbjct: 236 VCDLAAGHTRALEYL-GQGHGYHVWNLGTGTGYSVLQVIEAFERVSG--RRIPFT--VSG 290
Query: 274 GRGWKGDVKFMLLSIEKA-KKTGWR 297
R GDV + KA ++ GW+
Sbjct: 291 RR--PGDVAECWADVSKAERELGWK 313
>sp|P09147|GALE_ECOLI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|68390|pir||XUECUG UDPglucose
4-epimerase (EC 5.1.3.2) - Escherichia coli
>gi|2914620|pdb|1UDC| Structure Of
Udp-Galactose-4-Epimerase Complexed With Udp-Mannose
>gi|2981901|pdb|2UDP|A Chain A, Udp-Galactose
4-Epimerase Complexed With Udp-Phenol
>gi|2981902|pdb|2UDP|B Chain B, Udp-Galactose
4-Epimerase Complexed With Udp-Phenol
>gi|41523|emb|CAA29573.1| (X06226)
UDP-galactose-4-epimerase [Escherichia coli]
>gi|1651344|dbj|BAA35421.1| (D90714) UDP-glucose
4-epimerase (EC 5.1.3.2) (galactowaldenase).
[Escherichia coli] >gi|1786974|gb|AAC73846.1| (AE000178)
UDP-galactose-4-epimerase [Escherichia coli K12]
Length = 338
Score = 112 bits (278), Expect = 5e-24
Identities = 89/296 (30%), Positives = 146/296 (49%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD +P ES+ P S YG +KL E +++ + + R N
Sbjct: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>gb|AAK41125.1| dTDP-Glucose 4,6-dehydratase (rfbB-1) [Sulfolobus solfataricus]
Length = 317
Score = 112 bits (278), Expect = 5e-24
Identities = 90/277 (32%), Positives = 132/277 (47%), Gaps = 18/277 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
MK++V GGAGFIGS V L + G + V+D L+ AG ENL +++F++ D+R
Sbjct: 1 MKIIVVGGAGFIGSAFVRELNKRGIKPIVVDLLTYAGRKENLI----GTDYDFVQADVRS 56
Query: 60 YK---IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
K I+KE D+ V + AA V S P+ TNVL T NLL+A R+ N K+ V
Sbjct: 57 EKMHDIIKEYSPDI--VINFAAETHVDRSIYKPQDFVTTNVLGTVNLLEASRKFNFKY-V 113
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S+ VYG+ + PL+P S Y +K +A+ + Y +G A+I R +N
Sbjct: 114 HISTDEVYGE----ECGDENSPLKPSSPYSASKASADLFVKAYVRTYGISAVIVRPSNNY 169
Query: 177 GKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFD 236
G R + + + GDGK + ++ V DT IF+ R +
Sbjct: 170 GPRQFPEKLIPKAIIRTLLGIHIPVYGDGKAERDWIFVEDTAR---IIFDVVSRAEWKGE 226
Query: 237 VYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
VYN+ V EI +++ E G K KF G
Sbjct: 227 VYNIPGGQRYNVLEILKMLEEVSGKEVKIKFVSDRPG 263
>gb|AAK41973.1| dTDP-Glucose 4,6-dehydratase (rfbB-3) [Sulfolobus solfataricus]
Length = 312
Score = 112 bits (278), Expect = 5e-24
Identities = 87/272 (31%), Positives = 135/272 (48%), Gaps = 26/272 (9%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRDYK 61
+++ GGAGFIGS V + + G + V+D L+ AG ENL EFIR D+R +
Sbjct: 1 MIIIGGAGFIGSAFVREVNKRGIKPIVVDLLTYAGRKENLI----GTEHEFIRADVRSEE 56
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
I + V + ++V + AA V S P+ TNVL NLL+A R+ + K+ V S+
Sbjct: 57 I-HDIVKNSDIVVNFAAETHVDRSIYRPQDFVTTNVLGVVNLLEAARKYDFKY-VHISTD 114
Query: 122 TVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS- 180
VYG+ + PL+P S Y +K +A+ + Y +G +A+I R +N G R
Sbjct: 115 EVYGE----ECADEDSPLQPSSPYSASKASADLFVKAYVRTYGIKAIIVRPSNNYGPRQF 170
Query: 181 -----NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
+I F+N + I GDG+ + +++V DT+ I I E R
Sbjct: 171 PEKLIPKVIIRTFLNM------HVPIYGDGRAERDWIYVEDTVRIIYDIME---RSEWRG 221
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF 267
+VYN+ +V ++ +I+ E MG K KF
Sbjct: 222 EVYNIPGGQRYSVLDVIKIIGEIMGKEVKVKF 253
>sp|P13226|GALE_STRLI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE)
Length = 329
Score = 112 bits (278), Expect = 5e-24
Identities = 83/275 (30%), Positives = 130/275 (47%), Gaps = 24/275 (8%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
K LVTGGAG++GS + L+E G EV VL +LS G + F RGD+RD
Sbjct: 4 KYLVTGGAGYVGSVVAQHLVEAGNEVVVLHNLSTGFRAGVPA-----GASFYRGDIRDQD 58
Query: 62 IVKEAVD---DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+++ + V H AA +V S PE ++ NV T LL+A+R + V+ LVF+
Sbjct: 59 FMRKVFRGRLSFDGVLHFAAFSQVGESVVKPEKYWDNNVGGTMALLEAMRGAGVRRLVFS 118
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ YG+ +P ES P P + YG +KLA + +I+G A G A+ N+ G
Sbjct: 119 STAATYGEPEQVPIVES-APTRPTNPYGASKLAVDHMITGEAAAHGLGAVSVPYFNVAGA 177
Query: 179 RSNHGVIYD--------FINKLKRNPNELEILGDGKQR-----KSYLHVSDTINGILHIF 225
+++D + + + + GD + Y+HV+D H+
Sbjct: 178 NRGVRLVHDPESHLIPLVLQVAQGRREAISVYGDDYPTPDTCVRDYIHVADLAEA--HLL 235
Query: 226 EYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMG 260
+R + NLGN + +V+E+ E V G
Sbjct: 236 AVRRRPGNEHLICNLGNGNGFSVREVVETVRRVTG 270
>pir||S70889 nucleotide sugar epimerase homolog - Vibrio cholerae
>gi|1230585|gb|AAC46250.1| (U47057) nucleotide sugar
epimerase [Vibrio cholerae O139]
>gi|3724324|dbj|BAA33613.1| (AB012956) probable
nucleotide sugar epimerase [Vibrio cholerae]
>gi|1588979|prf||2209416J nucleotide sugar epimerase
[Vibrio cholerae]
Length = 334
Score = 112 bits (278), Expect = 5e-24
Identities = 76/287 (26%), Positives = 131/287 (45%), Gaps = 20/287 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW----LENENFEFIRGD 56
MK LVTG AGFIGS V +L E G+ V +D+++ NL +E+ F F++ D
Sbjct: 1 MKYLVTGAAGFIGSATVKKLTEQGHHVVGIDNINDYYDVNLKHARLARIEHPLFHFLKVD 60
Query: 57 MRDYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+ D + + + E V HLAA VR S ++P ++N++ N+L+ R++ V
Sbjct: 61 IADRAAMAQLFEQEKFERVIHLAAQAGVRYSLENPHAYADSNLVGHLNILEGCRQNKVGH 120
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
LV+ SSS+VYG +P S P+S+Y K + E + Y+H++ R
Sbjct: 121 LVYASSSSVYGLNAKVPFATSDSVDHPVSLYAATKKSNELMAHSYSHLYDIPTTGLRFFT 180
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
+ G + K ++I G + + HV D + G++ I + +N
Sbjct: 181 VYGSWGRPDMAPFIFTKKILAGEAIDINNHGDMWRDFTHVDDIVEGVVRIADVLPTRNAA 240
Query: 235 --------------FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF 267
+ +YN+G+ I + E + + E++G+ F
Sbjct: 241 WTVESGTPATSSAPYAIYNIGHGSPINLMEFVKAIEEQLGIEANKNF 287
>pir||T44339 hypothetical protein wbfW [imported] - Vibrio cholerae
>gi|3721693|dbj|BAA33643.1| (AB012957) probable
nucleotide sugar epimerase [Vibrio cholerae]
Length = 334
Score = 112 bits (278), Expect = 5e-24
Identities = 76/287 (26%), Positives = 131/287 (45%), Gaps = 20/287 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW----LENENFEFIRGD 56
MK LVTG AGFIGS V +L E G+ V +D+++ NL +E+ F F++ D
Sbjct: 1 MKYLVTGAAGFIGSATVKKLTEQGHHVVGIDNINDYYDVNLKHSRLARIEHPLFHFLKVD 60
Query: 57 MRDYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+ D + + + E V HLAA VR S ++P ++N++ N+L+ R++ V
Sbjct: 61 IADRAAMAQLFEQEKFERVIHLAAQAGVRYSLENPHAYADSNLVGHLNILEGCRQNKVGH 120
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
LV+ SSS+VYG +P S P+S+Y K + E + Y+H++ R
Sbjct: 121 LVYASSSSVYGLNAKVPFATSDSVDHPVSLYAATKKSNELMAHSYSHLYDIPTTGLRFFT 180
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
+ G + K ++I G + + HV D + G++ I + +N
Sbjct: 181 VYGSWGRPDMAPFIFTKKILAGEAIDINNHGDMWRDFTHVDDIVEGVVRIADVLPTRNAA 240
Query: 235 --------------FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF 267
+ +YN+G+ I + E + + E++G+ F
Sbjct: 241 WTVESGTPATSSAPYAIYNIGHGSPINLMEFVKAIEEQLGIEANKNF 287
>emb|CAB57474.1| (Y18930) dTDP-glucose 4,6-dehydratase (rfbB) [Sulfolobus
solfataricus]
Length = 317
Score = 112 bits (278), Expect = 5e-24
Identities = 90/277 (32%), Positives = 132/277 (47%), Gaps = 18/277 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
MK++V GGAGFIGS V L + G + V+D L+ AG ENL +++F++ D+R
Sbjct: 1 MKIIVVGGAGFIGSAFVRELNKRGIKPIVVDLLTYAGRKENLI----GTDYDFVQADVRS 56
Query: 60 YK---IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
K I+KE D+ V + AA V S P+ TNVL T NLL+A R+ N K+ V
Sbjct: 57 EKMHDIIKEYSPDI--VINFAAETHVDRSIYKPQDFVTTNVLGTVNLLEASRKFNFKY-V 113
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S+ VYG+ + PL+P S Y +K +A+ + Y +G A+I R +N
Sbjct: 114 HISTDEVYGE----ECGDENSPLKPSSPYSASKASADLFVKAYVRTYGISAVIVRPSNNY 169
Query: 177 GKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFD 236
G R + + + GDGK + ++ V DT IF+ R +
Sbjct: 170 GPRQFPEKLIPKAIIRTLLGIHIPVYGDGKAERDWIFVEDTAR---IIFDVVSRAEWKGE 226
Query: 237 VYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
VYN+ V EI +++ E G K KF G
Sbjct: 227 VYNIPGGQRYNVLEILKMLEEVSGKEVKIKFVSDRPG 263
>pdb|1UDB| Structure Of Udp-Galactose-4-Epimerase Complexed With
Udp-4-Deoxy-4-Fluoro-Alpha-D-Glucose
>gi|2914618|pdb|1UDA| Structure Of
Udp-Galactose-4-Epimerase Complexed With
Udp-4-Deoxy-4-Fluoro-Alpha-D-Galactose
>gi|1942804|pdb|1NAH| Udp-Galactose 4-Epimerase From
Escherichia Coli, Reduced >gi|1942240|pdb|1XEL|
Udp-Galactose 4-Epimerase From Escherichia Coli
>gi|1942805|pdb|1NAI| Udp-Galactose 4-Epimerase From
Escherichia Coli, Oxidized
Length = 338
Score = 112 bits (277), Expect = 6e-24
Identities = 89/296 (30%), Positives = 146/296 (49%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD +P ES+ P S YG +KL E +++ + + R N
Sbjct: 121 FSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>sp|Q56093|GALE_SALTI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|1073667|pir||S51328 UDPglucose
4-epimerase (EC 5.1.3.2) - Salmonella typhi
>gi|634103|emb|CAA58779.1| (X83927) UDP-galactose
4-epimerase [Salmonella typhi]
Length = 338
Score = 111 bits (276), Expect = 8e-24
Identities = 89/296 (30%), Positives = 146/296 (49%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVVILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S P Y+ NV T L+ A+R +NVK L+
Sbjct: 61 NEALITEILHDHAIDTVIHFAGLKAVGESVAKPLEYYDNNVNGTLRLVSAMRAANVKNLI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD +P ES+ P S YG +KL E +++ + + R N
Sbjct: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPEWSIALLRYFNP 180
Query: 176 IGKRSNHGV----------IYDFINKLKRNPNE-LEILG------DGKQRKSYLHVSDTI 218
+G + + + +I ++ E L + G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K +K +YNLG +V ++ S+ G + F DG
Sbjct: 241 DG--HVVAMEKLADKSGVHIYNLGAGVGSSVLDVVNAFSKACGKPINYHFAPRRDG 294
>pir||B69815 CDP-glucose 4,6-dehydratase homolog yfnG - Bacillus subtilis
>gi|2116765|dbj|BAA20116.1| (D86418) YfnG [Bacillus
subtilis] >gi|2633041|emb|CAB12547.1| (Z99107) similar
to CDP-glucose 4,6-dehydratase [Bacillus subtilis]
Length = 301
Score = 111 bits (276), Expect = 8e-24
Identities = 87/304 (28%), Positives = 141/304 (45%), Gaps = 21/304 (6%)
Query: 16 LVDRLMEDGYEVR--VLDDLSAGSLENLNRWLENENFEFIRGDMRDYKIVKEAVDDVEV- 72
+V L+E G V V D + NL + + +RG + D +++ A+ + E+
Sbjct: 1 MVKELIEQGANVTGLVRDHVPQS---NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEID 57
Query: 73 -VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESN-VKFLVFTSSSTVYGDANVL 130
VFHLAA V +++++P +E N+L T+N+L+A R+ +K ++ SS YGD L
Sbjct: 58 TVFHLAAQAIVGVANRNPISTFEANILGTWNILEACRKHPLIKRVIVASSDKAYGDQENL 117
Query: 131 PTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS-NHGVIYDFI 189
P E+ PL+ Y +K A+ + Y H +G I R N+ G N I
Sbjct: 118 PYDENM-PLQGKHPYDVSKSCADLISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQT 176
Query: 190 NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNLGNEDWITVK 249
+L N EI DG + Y ++ D + L + E + N + +N NE +TV
Sbjct: 177 IQLVLNGEAPEIRSDGTFVRDYFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVL 236
Query: 250 EIAEIVSEEM--GLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKK-TGWRPKMNSYEAV 306
E+ E + ++M L PK G ++K LS EKA+K W P E +
Sbjct: 237 ELVEKILKKMNSNLKPKVLNQG--------SNEIKHQYLSAEKARKLLNWTPAYTIDEGL 288
Query: 307 RRTV 310
+T+
Sbjct: 289 EKTI 292
>pdb|1KVR| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 111 bits (275), Expect = 1e-23
Identities = 88/296 (29%), Positives = 146/296 (48%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+S++TVYGD +P ES+ P S YG +KL E +++ + + R N
Sbjct: 121 FSSAATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>gb|AAF36926.1|AF221951_2 (AF221951) putative UDP-galactose 4-epimerase GalE [Rhodococcus
erythropolis]
Length = 329
Score = 111 bits (274), Expect = 1e-23
Identities = 95/324 (29%), Positives = 144/324 (44%), Gaps = 32/324 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+LVTGGAG++GS L+E G+EV V+DDLS G+ + + EFI GD+
Sbjct: 1 MKLLVTGGAGYVGSVCSTVLLERGHEVVVIDDLSTGNADAV-----PAGAEFIEGDVGAL 55
Query: 61 --KIVKEAVDDV-EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
++ A V + V H AA V S PE + NV+ T LL+AIR S LVF
Sbjct: 56 AADVLGSAGSPVFDGVLHFAAQSLVGESVLHPEKYWRGNVVTTIELLEAIRVSGTPRLVF 115
Query: 118 TSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
+S++ YG+ P E+ P P + YG KLA + I+ Y+ G A R N+ G
Sbjct: 116 SSTAATYGEPEQSPIVET-APTRPTNPYGATKLAIDHAITSYSIAHGLGATSLRYFNVAG 174
Query: 178 KRSNHG--------VIYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTINGILH 223
+ G +I + +++ + G DG + Y+HV D H
Sbjct: 175 AYKSAGENRVIETHLIPLVLQVALEQRDKISVFGTDWPTPDGTAVRDYIHVLDLAEA--H 232
Query: 224 IFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKF 283
+ +YNLG+ +V+E+ + GL V+ GD
Sbjct: 233 LLALESSVPGEHRIYNLGSGAGFSVREVIAACARVTGLPI------NVEDASRRLGDPAV 286
Query: 284 MLLSIEKA-KKTGWRPKMNSYEAV 306
++ S +KA + GW P + +
Sbjct: 287 LIASSDKAIAELGWTPTRTDLDVI 310
>gb|AAG26471.1|AF285774_11 (AF285774) putative UDP-glucuronic acid epimerase [Bacteroides
fragilis]
Length = 350
Score = 111 bits (274), Expect = 1e-23
Identities = 77/296 (26%), Positives = 136/296 (45%), Gaps = 36/296 (12%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSA--------GSLENLN------RWLE 46
M VLVTG AGFIGSH+ RL++ G EV LD++++ G L +L W +
Sbjct: 1 MNVLVTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGRLSSLGVPQSELSWYK 60
Query: 47 ------NENFEFIRGDMRDYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVL 98
F F+R ++ D + ++ A + +VV +LAA VR S ++P E+N+
Sbjct: 61 FTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGVRYSIENPYAYVESNID 120
Query: 99 ITYNLLQAIRESNVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG 158
N+L+ R S VK LV+ SSS+VYG +P E G P+S+Y K + E +
Sbjct: 121 GFLNVLEGCRHSQVKHLVYASSSSVYGLNGQVPFSEKDGIAHPVSLYAATKKSNELMAHT 180
Query: 159 YAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTI 218
Y+H++ + R + G + + +++ +G + + ++ D +
Sbjct: 181 YSHLYNIPSTGLRFFTVYGPWGRPDMSPFLFADAILHGRPIKVFNNGNMLRDFTYIDDIV 240
Query: 219 NGILHIFEYFKRQNKIFD--------------VYNLGNEDWITVKEIAEIVSEEMG 260
G+L + + N+ +D +YN+GN + + + + +G
Sbjct: 241 EGVLRVADSIPEGNQCWDAEVADPSMSCAPYKIYNIGNSRPVKLMDFIRAIEMSIG 296
>pdb|1KVS| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 111 bits (274), Expect = 1e-23
Identities = 88/296 (29%), Positives = 146/296 (48%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+S++TVYGD +P ES+ P S YG +KL E +++ + + R N
Sbjct: 121 FSSTATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>pdb|1KVU| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 111 bits (274), Expect = 1e-23
Identities = 88/296 (29%), Positives = 146/296 (48%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD +P ES+ P S +G +KL E +++ + + R N
Sbjct: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPFGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>pdb|1KVQ| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 111 bits (274), Expect = 1e-23
Identities = 88/296 (29%), Positives = 146/296 (48%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+S++TVYGD +P ES+ P S YG +KL E +++ + + R N
Sbjct: 121 FSSAATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>pir||H72588 probable dTDP-glucose 4,6-dehydratase APE1180 - Aeropyrum pernix
(strain K1) >gi|5104852|dbj|BAA80166.1| (AP000061) 330aa
long hypothetical dTDP-glucose 4,6-dehydratase
[Aeropyrum pernix]
Length = 330
Score = 110 bits (273), Expect = 2e-23
Identities = 97/319 (30%), Positives = 149/319 (46%), Gaps = 21/319 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME-DGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGGAGFIGS V ++ +EV V D L+ AG LENL+ + + F+RGD+
Sbjct: 1 MRVLVTGGAGFIGSSFVRYIVNTTDWEVLVYDKLTYAGRLENLHDVI--DRIGFMRGDIA 58
Query: 59 DYKIVKEAVDDVE--VVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRES-NVKFL 115
D + + + E VV + AA V S P TN++ + +L+AIR+ + L
Sbjct: 59 DEEQFGRVLTEFEPDVVVNFAAETHVDRSINEPAPFMRTNIIGVFTILEAIRKRIDQIVL 118
Query: 116 VFTSSSTVYGDA-NVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
+ S+ VYGD N PL P S Y +K + + LI Y +G + I R N
Sbjct: 119 LHVSTDEVYGDLWNTGKEATESDPLNPSSPYSASKASGDLLIKAYGRTYGLKYRIVRPCN 178
Query: 175 IIG--KRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
G + + I L P I GDG Q + +L+V DT I + E +
Sbjct: 179 NYGPYQHVEKLIPRTIIRILHGKPP--VIYGDGSQIRDWLYVEDTARAIHVVLE----KG 232
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAK 292
++YN+ TVK+I + E MG + + G+ G+ + + +K +
Sbjct: 233 VDGEIYNVCGGMASTVKDIVVNILESMGKPRDY-----LVYGKSRPGEDRRYAMKCDKIR 287
Query: 293 KTGWRPKMNSYEAVRRTVR 311
GW P + E ++ TV+
Sbjct: 288 NLGWAPHVTLKEGLKITVK 306
>pir||S49054 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [similarity] -
Streptomyces fradiae (strain T59235)
>gi|473600|gb|AAA21344.1| (U08223) dTDP-glucose
dehydratase [Streptomyces fradiae]
Length = 333
Score = 110 bits (272), Expect = 2e-23
Identities = 83/267 (31%), Positives = 122/267 (45%), Gaps = 12/267 (4%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY------EVRVLDDLS-AGSLENLNRWLENENFEFI 53
M+VLVTGGAGFIGSH +L+ Y VLD L+ AG+ NL + + EF+
Sbjct: 1 MRVLVTGGAGFIGSHFTGQLLTGAYPDLGATRTVVLDKLTYAGNPANLEHVAGHPDLEFV 60
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
RGD+ D+ + ++ V +V H AA V S +S E TNV T LLQA ++ V
Sbjct: 61 RGDIADHGWWRRLMEGVGLVVHFAAESHVDRSIESSEAFVRTNVEGTRVLLQAAVDAGVG 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
V S+ VYG PE + P+ P S Y K A++ L Y +G + R +
Sbjct: 121 RFVHISTDEVYGSIAEGSWPEDH-PVAPNSPYAATKAASDLLALAYHRTYGLDVRVTRCS 179
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
N G R + + + GDG + +LHV D G+ + +
Sbjct: 180 NNYGPRQYPEKAVPLFTTNLLDGLPVPLYGDGGNTREWLHVDDHCRGVALV----GAGGR 235
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMG 260
+YN+G +T E+ + + E G
Sbjct: 236 PGVIYNIGGGTELTNAELTDRILELCG 262
>gb|AAF82605.1| (AF144042) dTDP-glucose 4,6-dehydratase [Streptomyces rimosus
subsp. paromomycinus]
Length = 317
Score = 110 bits (272), Expect = 2e-23
Identities = 89/265 (33%), Positives = 127/265 (47%), Gaps = 11/265 (4%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY---EVRVLDDLS-AGSLENLNRWLENENFEFIRGD 56
MK LVTGGAGFIGSH V L+ DG V VLD L+ AG+L NL + F++GD
Sbjct: 1 MKTLVTGGAGFIGSHFVRSLLADGTGQEAVTVLDALTYAGNLANLRSVQGDPRLRFVQGD 60
Query: 57 MRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ D V E V + V +LAA V S + TNVL T LL+A ++ +V
Sbjct: 61 ILDSARVAELVAGHDAVVNLAAESHVDRSIANGAKFSSTNVLGTQTLLEAAVQAGGVTVV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
S+ VYG + E PL P S Y AK ++ L Y G I R +N
Sbjct: 121 HVSTDEVYGSIPIGSWTEE-EPLAPNSPYAAAKAGSDLLALAYHRTHGLDVRITRCSNNY 179
Query: 177 GK-RSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
G + +I FI +L + ++ + GDG Q + +LHV D I + E +
Sbjct: 180 GPYQFPEKIIPLFITRLLQG-RKVPLYGDGSQIRDWLHVVDHCRAIRLVLE----GGRAG 234
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMG 260
++YN+G +T K + + + + G
Sbjct: 235 EIYNVGGGTELTNKHLTDRLLDACG 259
>sp|Q59678|GALE_PASHA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|1304491|gb|AAC44098.1| (U39043) uridine
diphosphogalactose 4-epimerase [Pasteurella haemolytica]
Length = 338
Score = 109 bits (271), Expect = 3e-23
Identities = 95/334 (28%), Positives = 162/334 (48%), Gaps = 34/334 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR--WLENENFEFIRGDMR 58
M +LVTGGAG+IGSH + L+ + E+ VLD+LS S +L R + ++ +F +GD+
Sbjct: 1 MAILVTGGAGYIGSHTLVELLNENREIVVLDNLSNSSEVSLERVKQITGKSVKFYQGDIL 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D I+++ A + +E V H A V +S++ + + NV + L++ + ++NV +V
Sbjct: 61 DRDILRKIFAENQIESVIHFAGLKAVGETSENRYVTIKNNVTGSIVLVEEMLKANVNTIV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD ++P ES + YG +K E ++ F A++ R N
Sbjct: 121 FSSSATVYGDPQIIPIVESCPVGGTTNPYGTSKYMVERILEDTVKAFPQLSAVVLRYFNR 180
Query: 176 IGKRSNHGVIYDFINKLKRN------------PNELEILG------DGKQRKSYLHVSDT 217
+G + G+I + N + N +L + G DG + Y+HV D
Sbjct: 181 VGAHES-GLIGEDPNGIPNNLMPFISQVAVGKLPQLSVFGGDYNTHDGTGVRDYIHVVDL 239
Query: 218 INGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRG 276
G H+ K QN F VYNLG +V ++ + G++ +K VD
Sbjct: 240 ALG--HLKALDKHQNDAGFHVYNLGTGTGYSVLDMVKAFEAANGITIPYKV---VDRR-- 292
Query: 277 WKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVRRT 309
GD+ + +KA ++ GW + + ++ T
Sbjct: 293 -PGDIAVCYSAPQKALEQLGWETERGLEQMMKDT 325
>gb|AAD30579.1|AC007260_10 (AC007260) Similar to dTDP-D-glucose 4,6-dehydratase [Arabidopsis
thaliana]
Length = 669
Score = 109 bits (271), Expect = 3e-23
Identities = 85/318 (26%), Positives = 144/318 (44%), Gaps = 20/318 (6%)
Query: 3 VLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
+L+TG AGFI SH+ +RL+ Y++ VLD L +L+NLN + NF+F++GD+
Sbjct: 9 ILITGAAGFIASHVANRLIRSYPDYKIVVLDKLDYCSNLKNLNPSKHSPNFKFVKGDIAS 68
Query: 60 YKIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-ESNVKFLV 116
+V + + ++ + H AA V S + + N+ T+ LL+A + ++ +
Sbjct: 69 ADLVNHLLITEGIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFI 128
Query: 117 FTSSSTVYG--DANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
S+ VYG D + L L P + Y K AE L+ Y +G + R N
Sbjct: 129 HVSTDEVYGETDEDALVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNN 188
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
+ G + L L I GDG +SYL+ D + FE + ++
Sbjct: 189 VYGPNQFPEKLIPKFILLAMRGQVLPIHGDGSNVRSYLYCED----VAEAFEVVLHKGEV 244
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPK--FKFTGGVDGGRGWKGDVKFMLLSIEKAK 292
VYN+G + V ++A+ + + + P+ KF R + F L +K K
Sbjct: 245 GHVYNIGTKKERRVNDVAKDICKLFNMDPEANIKFV----DNRPFNDQRYF--LDDQKLK 298
Query: 293 KTGWRPKMNSYEAVRRTV 310
K GW + E +++T+
Sbjct: 299 KLGWSERTTWEEGLKKTM 316
>pdb|1KVT| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 109 bits (271), Expect = 3e-23
Identities = 88/296 (29%), Positives = 145/296 (48%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+S +TVYGD +P ES+ P S YG +KL E +++ + + R N
Sbjct: 121 FSSVATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>pdb|1A9Y| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXED WITH
Udp-Glucose
Length = 338
Score = 109 bits (271), Expect = 3e-23
Identities = 87/296 (29%), Positives = 146/296 (48%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+S++TVYGD +P ES+ P S +G +KL E +++ + + R N
Sbjct: 121 FSSAATVYGDQPKIPYVESFPTGTPQSPFGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>sp|P14169|RFBE_SALTI CDP-TYVELOSE-2-EPIMERASE >gi|861175|gb|AAB49384.1| (M29682)
CDP-tyvelose epimerase [Salmonella enterica]
Length = 338
Score = 109 bits (270), Expect = 4e-23
Identities = 97/340 (28%), Positives = 170/340 (49%), Gaps = 42/340 (12%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS-AGSLENLNRWLEN-ENFEFIRGDMR 58
MK+L+TGG GF+GS+L + G ++ V D+LS G+ +NL+ WL + NFEF+ GD+R
Sbjct: 1 MKLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLH-WLSSLGNFEFVHGDIR 59
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF-L 115
+ V + + FHLA + S +P + +E NV T NLL+A+R+ N +
Sbjct: 60 NKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCNI 119
Query: 116 VFTSSSTVYGDA------------NVLPTPESYG---PLEPISVYGGAKLAAEALISGYA 160
+++S++ VYGD + P Y L+ S YG +K AA+ + YA
Sbjct: 120 IYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDYA 179
Query: 161 HIFGFRALIFRLANIIGKRS----NHGVIYDFINK---LKRNPNE-LEILGDGKQRKSYL 212
IFG ++FR +++ G R + G + F K +K N+ I G+GKQ + L
Sbjct: 180 RIFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTISGNGKQVRDVL 239
Query: 213 HVSDTINGILHIFEYFKRQNKI-FDVYNLGNE--DWITVKEIAEIVSEEMGLSPKF-KFT 268
H D I+ F +KI + +N+G + +++ E+ +++ + + +F
Sbjct: 240 HAEDMIS---LYFTALANVSKIRGNAFNIGGTIVNSLSLLELFKLLEDYCNIDMRFTNLP 296
Query: 269 GGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRR 308
R + D+K + +I+ W PK+++ + V++
Sbjct: 297 VRESDQRVFVADIKKITNAID------WSPKVSAKDGVQK 330
>pdb|1A9Z| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXED WITH
Udp-Galactose
Length = 338
Score = 109 bits (270), Expect = 4e-23
Identities = 87/296 (29%), Positives = 146/296 (48%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S Q P Y+ NV T L+ A+R +NVK +
Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+S++TVYGD +P ES+ P S +G +KL E +++ + + R N
Sbjct: 121 FSSAATVYGDNPKIPYVESFPTGTPQSPFGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180
Query: 176 IGKRSN-------HGVIYDFINKLKR----NPNELEILG------DGKQRKSYLHVSDTI 218
+G + G+ + + + + + L I G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
+G H+ K NK +YNLG +V ++ S+ G + F +G
Sbjct: 241 DG--HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294
>sp|P55180|GALE_BACSU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437225|pir||D69628 UDPglucose
4-epimerase (EC 5.1.3.2) - Bacillus subtilis
>gi|1429254|emb|CAA67713.1| (X99339) UDP-glucose
4-epimerase [Bacillus subtilis]
>gi|1783241|dbj|BAA11718.1| (D83026) highly homologous
to UDP-glucose 4-epimerases (SwissProt:GALE_HAEIN and
GALE_ECOLI); hypothetical [Bacillus subtilis]
>gi|2636421|emb|CAB15912.1| (Z99123) UDP-glucose
4-epimerase [Bacillus subtilis]
Length = 339
Score = 109 bits (269), Expect = 6e-23
Identities = 99/324 (30%), Positives = 142/324 (43%), Gaps = 35/324 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE--NENFEFIRGDMR 58
M +LVTGGAG+IGSH L+ GYE+ VLD+LS S E LNR E ++ F D+
Sbjct: 1 MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLL 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D + V A +++E V H A V S P Y N+ T+ L +A+ + VK +V
Sbjct: 61 DREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLANI 175
F+SS+TVYG P E + PL + YG KL E ++ + + + R N
Sbjct: 121 FSSSATVYGVPETSPITEDF-PLGATNPYGQTKLMLEQILRDLHTADNEWSVALLRYFNP 179
Query: 176 IGKRSNHGVIYDFINKLKRN------------PNELEILG------DGKQRKSYLHVSDT 217
G + G I + N + N +L + G DG + Y+HV D
Sbjct: 180 FGAHPS-GRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDL 238
Query: 218 INGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRG 276
G H+ K N D YNLG +V E+ + + G ++F
Sbjct: 239 AEG--HVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFAD------R 290
Query: 277 WKGDVKFMLLSIEKAKK-TGWRPK 299
GD+ KAK+ GW K
Sbjct: 291 RPGDIATCFADPAKAKRELGWEAK 314
>gb|AAD50494.1|AF172324_12 (AF172324) WbnF [Escherichia coli]
Length = 334
Score = 108 bits (267), Expect = 9e-23
Identities = 71/281 (25%), Positives = 131/281 (46%), Gaps = 20/281 (7%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR----WLENENFEFIRGD 56
MK LVTG AGFIG ++ RL+ G++V +D+L+ NL + L+++NF F + D
Sbjct: 1 MKFLVTGAAGFIGFYVSKRLLAAGHQVVGIDNLNDYYDVNLKQARLDLLKHDNFSFYKID 60
Query: 57 MRDYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+ D + + D + V +LAA VR S ++P + N++ N+L+ R +NV+
Sbjct: 61 LADREKMAALFADERFDRVINLAAQAGVRYSLENPNAYADANLIGFLNILEGCRHNNVQH 120
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
L++ SSS+VYG +P P+S+Y K A E + Y+H++G R
Sbjct: 121 LLYASSSSVYGMNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPTTGLRFFT 180
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQ--- 231
+ G + K +++ GK ++ + ++ D I+ + + +
Sbjct: 181 VYGPWGRPDMALFKFTKAMLEGKSIDVYNFGKMKRDFTYIDDIAEAIIRLQDVIPEKDPQ 240
Query: 232 -----------NKIFDVYNLGNEDWITVKEIAEIVSEEMGL 261
+ + VYN+GN + + + + E +G+
Sbjct: 241 WTVETGSPATSSAPYRVYNIGNSSPVELMDYINALEEALGI 281
>gb|AAC78676.1| (AF094575) dTDP-glucose-4,6-dehydratase Cps19aN [Streptococcus
pneumoniae]
Length = 349
Score = 108 bits (266), Expect = 1e-22
Identities = 92/324 (28%), Positives = 155/324 (47%), Gaps = 38/324 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
++VTGGAGFIGS+ V + E+ V VLD L+ AG+ N+ L N E + GD+ D
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGNR-VELVVGDIAD 65
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++V + + + H AA S P TN + TY LL+A R+ +++F S
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDIRF-HHVS 124
Query: 120 SSTVYGDANVLPTPESY-----GPLE---------PISVYGGAKLAAEALISGYAHIFGF 165
+ VYGD LP E GP E P S Y K A++ ++ + FG
Sbjct: 125 TDEVYGD---LPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGV 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRN---PNELEILGDGKQRKSYLHVSDTINGIL 222
+A I +N G + I FI + N + ++ G+GK + ++H +D +G+
Sbjct: 182 KATISNCSNNYGPYQH---IEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVW 238
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DV 281
I + +I + Y +G + KE+ E++ +EMG + T D G D+
Sbjct: 239 TIL----TKGQIGETYLIGADGEKNNKEVLELILKEMG-----QATDAYDHVTDRAGHDL 289
Query: 282 KFMLLSIEKAKKTGWRPKMNSYEA 305
++ + + + ++ GW+P+ ++EA
Sbjct: 290 RYAIDASKLREELGWKPEFTNFEA 313
>pir||B33604 rfbE protein - Salmonella sp
Length = 348
Score = 107 bits (265), Expect = 2e-22
Identities = 82/247 (33%), Positives = 129/247 (52%), Gaps = 29/247 (11%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS-AGSLENLNRWLEN-ENFEFIRGDMR 58
MK+L+TGG GF+GS+L + G ++ V D+LS G+ +NL+ WL + NFEF+ GD+R
Sbjct: 1 MKLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLH-WLSSLGNFEFVHGDIR 59
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF-L 115
+ V + + FHLA + S +P + +E NV T NLL+A+R+ N +
Sbjct: 60 NKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCNI 119
Query: 116 VFTSSSTVYGDA------------NVLPTPESYG---PLEPISVYGGAKLAAEALISGYA 160
+++S++ VYGD + P Y L+ S YG +K AA+ + YA
Sbjct: 120 IYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDYA 179
Query: 161 HIFGFRALIFRLANIIGKRS----NHGVIYDFINK---LKRNPNE-LEILGDGKQRKSYL 212
IFG ++FR +++ G R + G + F K +K N+ I G+GKQ + L
Sbjct: 180 RIFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTISGNGKQVRDVL 239
Query: 213 HVSDTIN 219
H D I+
Sbjct: 240 HAEDMIS 246
>sp|P35673|GALE_ERWAM UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|1073276|pir||A36951 UDPglucose
4-epimerase (EC 5.1.3.2) - Erwinia amylovora
>gi|429078|emb|CAA53767.1| (X76172) UDP-glucose
4-epimerase [Erwinia amylovora]
Length = 337
Score = 107 bits (264), Expect = 2e-22
Identities = 88/296 (29%), Positives = 137/296 (45%), Gaps = 25/296 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENFEFIRGDMR 58
M +LVTGGAG+IGSH V L++ G +V +LD+LS S E++NR L + F GD+
Sbjct: 1 MSILVTGGAGYIGSHTVLSLLQRGDDVVILDNLSNASRESINRVEKLTGKTATFFEGDLL 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D ++ + + V H A V S++ P Y+ NV T LL+ +R + V +
Sbjct: 61 DRSCLRSVFSAHRISAVIHFAGLKAVGASTRKPLEYYQNNVTGTLVLLEEMRSAGVNQFI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYG +P E+ S YG +KL E ++ YA F+ + R N
Sbjct: 121 FSSSATVYGADAPVPYVETTPIGGTTSPYGTSKLMVEQILRDYAKANPEFKTIALRYFNP 180
Query: 176 IGKRSNHGVIYDFINKLKRN---------PNELEILG---------DGKQRKSYLHVSDT 217
+G + G + + N + N LE LG DG + Y+HV D
Sbjct: 181 VGAHES-GQMGEDPNGIPNNLLPYIAQVAIGRLEKLGIFGDDYPTEDGTGVRDYIHVMDL 239
Query: 218 INGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
G L ++ + YNLG +V E+ + + G + ++ + DG
Sbjct: 240 AEGHLKALDHLSAIEG-YKAYNLGAGKGYSVLEMVKAFEKASGGTVAYQISPRRDG 294
>pir||T44844 UDPglucose 4-epimerase (EC 5.1.3.2) [imported] - Acinetobacter
lwoffii >gi|6010005|emb|CAB57212.1| (AJ243431) putative
UDP-glucose 4-epimerase [Acinetobacter lwoffii]
Length = 338
Score = 107 bits (264), Expect = 2e-22
Identities = 93/322 (28%), Positives = 149/322 (45%), Gaps = 32/322 (9%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW--LENENFEFIRGDMRD 59
K+LVTGGAG+IGSH L+ G+EV V D+LS S E L R L N++ FI+GD+R+
Sbjct: 3 KILVTGGAGYIGSHTCIELLNAGHEVIVFDNLSNSSEEALRRVQKLTNKSLVFIQGDIRN 62
Query: 60 YKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
+ D ++ V H A V S Q P ++ N+ + L +++ ++ V LVF
Sbjct: 63 QSELDLVFQDHQIDAVIHFAGLKAVGESQQIPLTYFDNNIAGSIQLTKSMEKAGVFKLVF 122
Query: 118 TSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHI-FGFRALIFRLANII 176
+SS+TVY + N P E P + YG KL E L+ AH + + R N +
Sbjct: 123 SSSATVYDEVNTSPLNEDMSTGIPNNNYGYTKLIVEQLLQKLAHADRRWSIALLRYFNPV 182
Query: 177 GKRSNHGV----------IYDFINKLKRNPNE-LEILG------DGKQRKSYLHVSDTIN 219
G + + + ++ ++ E L I G DG + Y+HV D N
Sbjct: 183 GAHKSGQIGEDPQGIPNNLMPYVTQVAVGRREKLSIYGNDYDTVDGTGVRDYIHVVDLAN 242
Query: 220 GILHIFEYFKRQN-KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWK 278
H+ R + + V+N+G + +V ++ + G+S F+F
Sbjct: 243 A--HLCALSNRLSAQGCRVWNIGTGNGSSVLQVKNTFEQVNGVSIAFEFVS------RRA 294
Query: 279 GDVKFMLLSIEKAK-KTGWRPK 299
GDV +A+ + GW+P+
Sbjct: 295 GDVATSFADNTRAQLELGWKPQ 316
>emb|CAB05928.1| (Z83335) unknown [Streptococcus pneumoniae]
Length = 356
Score = 106 bits (262), Expect = 4e-22
Identities = 88/342 (25%), Positives = 160/342 (46%), Gaps = 38/342 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLME--------------DGYEVRVLDDLSAGSLENLNRWLENE 48
+L+TG AGFIGS+LV +L+E D Y++ L D L L + +
Sbjct: 6 ILITGVAGFIGSNLVRKLLELEGTMTIIGLDNLNDYYDI-ALKDYRLLQLNKLIQDYPEK 64
Query: 49 NFEFIRGDMRDYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQA 106
N+ FI+GD+ D ++ + ++V +LAA VR S +P++ E+N++ +N+L+A
Sbjct: 65 NWIFIKGDIADKMLINKIFKSYHPQIVVNLAAQAGVRYSITNPDVYIESNIVGFHNVLEA 124
Query: 107 IRES------NVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYA 160
R S V+ LV+ SSS+VYG +P PIS+Y K E Y+
Sbjct: 125 CRHSYEIYDGGVEHLVYASSSSVYGGNKKIPFATEDKVDNPISLYAATKKTNELQAYAYS 184
Query: 161 HIFGFRALIFRLANIIGKRSNHGVIY-DFINKLKRNPNELEILGDGKQRKSYLHVSDTIN 219
I+ + R + G + Y F +KL R+ +++EI G ++ + ++ D +
Sbjct: 185 KIYNIPSTGLRFFTVYGPAGRPDMAYFGFTDKL-RSGSDIEIYNHGNCKRDFTYIDDIVE 243
Query: 220 GILHIFEYFKRQ--------NKIFDVYNLGNEDWITVKEIAEIVSEEM---GLSPK-FKF 267
GI+ + + ++ + VYN+GN + + +++ +E+ G+ P+ + F
Sbjct: 244 GIVRVMQSAPKKLVGSDNLPLAPYKVYNIGNSKPENLLDFVDVLQQELIKAGVLPENYDF 303
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKAKKT-GWRPKMNSYEAVRR 308
GDV ++ G++PK + E +R+
Sbjct: 304 DSHKKLVPMQPGDVPVTYADTSDLERDFGFKPKTSLREGLRK 345
>emb|CAB05932.1| (Z83335) dTDP-glucose 4,6-dehydratase [Streptococcus pneumoniae]
Length = 349
Score = 106 bits (262), Expect = 4e-22
Identities = 92/324 (28%), Positives = 154/324 (47%), Gaps = 38/324 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
++VTGGAGFIGS+ V + E+ V VLD L+ AG+ N+ L N E + GD+ D
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGNR-VELVVGDIAD 65
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++V + V + + H AA S P TN + Y LL+A R+ +++F S
Sbjct: 66 AELVDKLVAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGIYTLLEAARKYDIRF-HHVS 124
Query: 120 SSTVYGDANVLPTPESY-----GPLE---------PISVYGGAKLAAEALISGYAHIFGF 165
+ VYGD LP E GP E P S Y K A++ ++ + FG
Sbjct: 125 TDEVYGD---LPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGV 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRN---PNELEILGDGKQRKSYLHVSDTINGIL 222
+A I +N G + I FI + N + ++ G+GK + ++H +D +G+
Sbjct: 182 KATISNCSNNYGPYQH---IEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVW 238
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DV 281
I + +I + Y +G + KE+ E++ +EMG + T D G D+
Sbjct: 239 TIL----TKGQIGETYLIGADGEKNNKEVLELILKEMG-----QATDAYDHVTDRAGHDL 289
Query: 282 KFMLLSIEKAKKTGWRPKMNSYEA 305
++ + + + + GW+P+ ++EA
Sbjct: 290 RYAIDASKLRDELGWKPEFTNFEA 313
>pir||T44521 polysaccharide biosynthetic protein [imported] - Shigella sonnei
>gi|6009798|dbj|BAA85072.1| (AB028135) ORF2S [Shigella
sonnei] >gi|10442656|gb|AAG17409.1|AF285970_3 (AF285970)
WbgU [Plesiomonas shigelloides]
>gi|10442667|gb|AAG17419.1|AF285971_3 (AF285971) WbgU
[Shigella sonnei]
Length = 345
Score = 106 bits (262), Expect = 4e-22
Identities = 76/272 (27%), Positives = 130/272 (46%), Gaps = 21/272 (7%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLN---------RWLENENFEFIR 54
L+TG AGFIGS+L+++L++ V LD+ S G NL+ +W F FI
Sbjct: 23 LITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQW---SRFCFIE 79
Query: 55 GDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
GD+RD ++ + V+ V H AA V S P TN+ N+L A + + V+
Sbjct: 80 GDIRDLTTCEQVMKGVDHVLHQAALGSVPRSIVDPITTNATNITGFLNILHAAKNAQVQS 139
Query: 115 LVFTSSSTVYGDANVLP-TPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+ +SS+ YGD LP E+ G P+S Y K E YA +GF+ + R
Sbjct: 140 FTYAASSSTYGDHPALPKVEENIG--NPLSPYAVTKYVNEIYAQVYARTYGFKTIGLRYF 197
Query: 174 NIIGKRSNHGVIYDFI----NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFK 229
N+ G+R + Y + +++ I GDG+ + + ++ + I ++I
Sbjct: 198 NVFGRRQDPNGAYAAVIPKWTAAMLKGDDVYINGDGETSRDFCYIDNVIQ--MNILSALA 255
Query: 230 RQNKIFDVYNLGNEDWITVKEIAEIVSEEMGL 261
+ + ++YN+ D T+ E++ + +E+ L
Sbjct: 256 KDSAKDNIYNVAVGDRTTLNELSGYIYDELNL 287
>gb|AAF78439.1|AC018748_18 (AC018748) Contains similarity to dTPD-D-glucose-4,6-dehydratase
from Sphingomonas sp.S88 gb|U51197 and contains a NAD
dependent epimerase/dehydratase PF|01370 domain.
[Arabidopsis thaliana]
>gi|10645356|gb|AAG21476.1|AC024260_19 (AC024260)
dTDP-D-glucose 4,6-dehydratase, putative; 102946-105028
[Arabidopsis thaliana]
Length = 667
Score = 106 bits (262), Expect = 4e-22
Identities = 81/316 (25%), Positives = 144/316 (44%), Gaps = 16/316 (5%)
Query: 3 VLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
+L+TG AGFI SH+ +RL+ + Y++ VLD L L+NL+ + NF+F++GD+
Sbjct: 11 ILITGAAGFIASHVANRLIRNYPDYKIVVLDKLDYCSDLKNLDPSFSSPNFKFVKGDIAS 70
Query: 60 YKIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-ESNVKFLV 116
+V + ++++ + H AA V S + + N+ T+ LL+A + ++ +
Sbjct: 71 DDLVNYLLITENIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFI 130
Query: 117 FTSSSTVYG--DANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
S+ VYG D + L P + Y K AE L+ Y +G + R N
Sbjct: 131 HVSTDEVYGETDEDAAVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNN 190
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
+ G + L + L I GDG +SYL+ D + FE + +I
Sbjct: 191 VYGPNQFPEKMIPKFILLAMSGKPLPIHGDGSNVRSYLYCED----VAEAFEVVLHKGEI 246
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKT 294
VYN+G + V ++A + + G P+ + + + L +K KK
Sbjct: 247 GHVYNVGTKRERRVIDVARDICKLFGKDPE----SSIQFVENRPFNDQRYFLDDQKLKKL 302
Query: 295 GWRPKMNSYEAVRRTV 310
GW+ + N + +++T+
Sbjct: 303 GWQERTNWEDGLKKTM 318
>gb|AAF78483.1|AC012187_3 (AC012187) Strong similarity to UDPglucose 4-epimerase from
Arabidopsis thaliana gi|2129759 and is a member of the
NAD dependent Epimerase/Dehydratase PF|01370 family.
ESTs gb|AI100184, gb|T22969, gb|T22968, gb|H76416,
gb|AI998807 come from this gene
Length = 351
Score = 106 bits (262), Expect = 4e-22
Identities = 91/334 (27%), Positives = 153/334 (45%), Gaps = 37/334 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE------NENFEFIRGD 56
+LVTGGAGFIG+H V +L++DG++V ++D+ +E ++R E ++ +F GD
Sbjct: 9 ILVTGGAGFIGTHTVVQLLKDGFKVSIIDNFDNSVIEAVDRVRELVGPDLSKKLDFNLGD 68
Query: 57 MRDYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+R+ +++ + + V H A V S ++P ++ N++ T NL + + + N K
Sbjct: 69 LRNKGDIEKLFSKQRFDAVIHFAGLKAVGESVENPRRYFDNNLVGTINLYETMAKYNCKM 128
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLA 173
+VF+SS+TVYG +P E + L+ ++ YG KL E + +R ++ R
Sbjct: 129 MVFSSSATVYGQPEKIPCMEDF-ELKAMNPYGRTKLFLEEIARDIQKAEPEWRIILLRYF 187
Query: 174 NIIGKRSNHGV----------IYDFINKLK--RNPNELEILG------DGKQRKSYLHVS 215
N +G + + + +I ++ R P EL + G DG + Y+HV
Sbjct: 188 NPVGAHESGSIGEDPKGIPNNLMPYIQQVAVGRLP-ELNVYGHDYPTEDGSAVRDYIHVM 246
Query: 216 DTINGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGG 274
D +G + KI YNLG +V E+ + G K
Sbjct: 247 DLADGHIAALRKLFADPKIGCTAYNLGTGQGTSVLEMVAAFEKASGKKIPIKLC------ 300
Query: 275 RGWKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + S EKA K+ GW+ K E R
Sbjct: 301 PRRSGDATAVYASTEKAEKELGWKAKYGVDEMCR 334
>dbj|BAB06023.1| (AP001515) nucleotide sugar epimerase (capsular polysaccharide
biosynthesis) [Bacillus halodurans]
Length = 315
Score = 106 bits (262), Expect = 4e-22
Identities = 76/274 (27%), Positives = 130/274 (46%), Gaps = 14/274 (5%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMED------GYEVRVLDDLSAGSLENLNRWLENENFEFIR 54
M++LVTG AGFIGSHL ++L+ + G + + L N+ L++ F ++
Sbjct: 1 MRILVTGAAGFIGSHLCEQLLMNEKVSVVGVDGHIDSSLCKVKERNVRNLLKHPRFTLLK 60
Query: 55 GDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYET-NVLITYNLLQAIRESNVK 113
D+ + + VD V+V++HL+ P VR S + Y T N++ T LL+A R +++
Sbjct: 61 QDLLTIDL-EPLVDQVDVIYHLSGIPGVRSSWGTDFKKYVTHNIVATQQLLEACRRHSLE 119
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
++ S+S+VYG N E P P+S YG +KL E L + Y F +I R
Sbjct: 120 KFIYISTSSVYGQKNG-KVGEKASPT-PLSPYGVSKLTGEHLCNVYYRNFSIPTVILRYF 177
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
+ G R + + K + + I GDG Q + + ++ D I + +
Sbjct: 178 TVYGPRQRQDMAFHRFIKAIIDNQPIPIFGDGNQSRDFTYIDDCIAATCAVL----HADV 233
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF 267
I + N+G ++ TV +I ++ K +F
Sbjct: 234 IGETINIGGKERATVLQIISMLESIFQKDAKLQF 267
>gb|AAC46054.1| (U78089) UDP-glucose epimerase [Brucella abortus]
Length = 335
Score = 106 bits (261), Expect = 5e-22
Identities = 93/275 (33%), Positives = 133/275 (47%), Gaps = 29/275 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIR---GDM 57
M +LVTGGAG+IGSH +L+E G+EV V+D+ E L+R +E R GD+
Sbjct: 1 MTILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHR-IEKITGRAPRREPGDI 59
Query: 58 RDYKIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
RD ++++ + V H A V SS+ P L Y+ NVL T LLQA+ + VK L
Sbjct: 60 RDRALMEQVIKRHKCTAVIHFAGLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATGVKKL 119
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLAN 174
VF+SS+TVYGD + LP E PL + YG KL E ++ Y + I R N
Sbjct: 120 VFSSSATVYGDPDKLPITEDQ-PLSATNPYGRTKLVIEDMLRDLYNSDNSWAIAILRYFN 178
Query: 175 IIGKRSNHGVIYDFINKLKRN------------PNELEILG------DGKQRKSYLHVSD 216
+G + G+I + + N +L I G DG + Y+HV+D
Sbjct: 179 PVGAHES-GLIGEDPKGIPNNLMPIIAQVATGRREKLNIWGNDYPTPDGTGVRDYIHVND 237
Query: 217 TINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEI 251
G L + + K F V NLG +V ++
Sbjct: 238 LAAGHLKALKKLDKP-KCFAV-NLGTGQGYSVLDV 270
>pir||T01881 UDPglucose 4-epimerase (EC 5.1.3.2) F8M12.10 - Arabidopsis thaliana
>gi|3513739|gb|AAC33955.1| (AF080118) Similar to uridine
diphosphate glucose epimerase; F8M12.10 [Arabidopsis
thaliana]
Length = 350
Score = 106 bits (261), Expect = 5e-22
Identities = 93/332 (28%), Positives = 153/332 (46%), Gaps = 35/332 (10%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE-----NENFEFIRGDM 57
VLV+GGAG+IGSH V +L+ GY V V+D+L S +L R + E F + D+
Sbjct: 5 VLVSGGAGYIGSHTVLQLLLGGYSVVVVDNLDNSSAVSLQRVKKLAAEHGERLSFHQVDL 64
Query: 58 RDYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
RD +++ + + V H A V S + P L Y N++ T LL+ + + K L
Sbjct: 65 RDRSALEKIFSETKFDAVIHFAGLKAVGESVEKPLLYYNNNLVGTITLLEVMAQHGCKNL 124
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLAN 174
VF+SS+TVYG +P E + P+ ++ YG KL E + Y ++ ++ R N
Sbjct: 125 VFSSSATVYGSPKEVPCTEEF-PISALNPYGRTKLFIEEICRDVYGSDPEWKIILLRYFN 183
Query: 175 IIGKRSNHGV----------IYDFINKLK--RNPNELEILG------DGKQRKSYLHVSD 216
+G + + + F+ ++ R P+ L + G DG + Y+HV D
Sbjct: 184 PVGAHPSGDIGEDPRGIPNNLMPFVQQVAVGRRPH-LTVFGNDYNTKDGTGVRDYIHVID 242
Query: 217 TINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRG 276
+G + + +VYNLG + +V E+ + + G K + G R
Sbjct: 243 LADGHIAALRKLEDCKIGCEVYNLGTGNGTSVLEMVDAFEKASGK----KIPLVIAGRR- 297
Query: 277 WKGDVKFMLLSIEKAK-KTGWRPKMNSYEAVR 307
GD + + S E+A+ + W+ K E R
Sbjct: 298 -PGDAEVVYASTERAESELNWKAKYGIEEMCR 328
>pir||T04291 probable UDPglucose 4-epimerase (EC 5.1.3.2) - Arabidopsis thaliana
>gi|4539370|emb|CAB40064.1| (AL049525) UDP-galactose
4-epimerase-like protein [Arabidopsis thaliana]
>gi|7267794|emb|CAB81197.1| (AL161518) UDP-galactose
4-epimerase-like protein [Arabidopsis thaliana]
Length = 351
Score = 106 bits (261), Expect = 5e-22
Identities = 93/332 (28%), Positives = 153/332 (46%), Gaps = 35/332 (10%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE-----NENFEFIRGDM 57
VLV+GGAG+IGSH V +L+ GY V V+D+L S +L R + E F + D+
Sbjct: 6 VLVSGGAGYIGSHTVLQLLLGGYSVVVVDNLDNSSAVSLQRVKKLAAEHGERLSFHQVDL 65
Query: 58 RDYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
RD +++ + + V H A V S + P L Y N++ T LL+ + + K L
Sbjct: 66 RDRSALEKIFSETKFDAVIHFAGLKAVGESVEKPLLYYNNNLVGTITLLEVMAQHGCKNL 125
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLAN 174
VF+SS+TVYG +P E + P+ ++ YG KL E + Y ++ ++ R N
Sbjct: 126 VFSSSATVYGSPKEVPCTEEF-PISALNPYGRTKLFIEEICRDVYGSDPEWKIILLRYFN 184
Query: 175 IIGKRSNHGV----------IYDFINKLK--RNPNELEILG------DGKQRKSYLHVSD 216
+G + + + F+ ++ R P+ L + G DG + Y+HV D
Sbjct: 185 PVGAHPSGDIGEDPRGIPNNLMPFVQQVAVGRRPH-LTVFGNDYNTKDGTGVRDYIHVID 243
Query: 217 TINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRG 276
+G + + +VYNLG + +V E+ + + G K + G R
Sbjct: 244 LADGHIAALRKLEDCKIGCEVYNLGTGNGTSVLEMVDAFEKASGK----KIPLVIAGRR- 298
Query: 277 WKGDVKFMLLSIEKAK-KTGWRPKMNSYEAVR 307
GD + + S E+A+ + W+ K E R
Sbjct: 299 -PGDAEVVYASTERAESELNWKAKYGIEEMCR 329
>sp|P22715|GALE_SALTY UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|96866|pir||A37760 UDPglucose
4-epimerase (EC 5.1.3.2) - Salmonella typhimurium
>gi|154047|gb|AAA27111.1| (M33681) uridine
diphosphogalactose 4-epimerase (galE) (EC 5.1.3.2)
[Salmonella typhimurium]
Length = 337
Score = 106 bits (261), Expect = 5e-22
Identities = 86/290 (29%), Positives = 143/290 (48%), Gaps = 25/290 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL--SAGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGG+G+IGSH +L+++G++V +LD+L S S+ + L ++ F+ GD+R
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVVILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
+ ++ E + D ++ V H A V S P Y+ NV T L+ A+R +NVK L+
Sbjct: 61 NEALITEILHDHAIDTVIHFAGLKAVGNSVARPLEYYDNNVNGTLRLVSAMRAANVKNLI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD +P ES+ P S G +KL E +++ + + R N
Sbjct: 121 FSSSATVYGDQPKIPYVESFPTGAPQSPTGKSKLMVEQILTDLQKAQPEWSIALLRYFNP 180
Query: 176 IGKRSNHGV----------IYDFINKLKRNPNE-LEILG------DGKQRKSYLHVSDTI 218
+G + + + +I ++ E L + G DG + Y+HV D
Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF 267
+G H+ K +K +YNLG +V ++ S+ G + F
Sbjct: 241 DG--HVVAMEKLADKSGVHIYNLGAGVGSSVLDVVNAFSKACGKPINYHF 288
>gb|AAG12659.1|AC010795_3 (AC010795) uridine diphosphate glucose epimerase, putative;
80611-78786 [Arabidopsis thaliana]
Length = 353
Score = 105 bits (260), Expect = 6e-22
Identities = 92/336 (27%), Positives = 153/336 (45%), Gaps = 39/336 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE------NENFEFIRGD 56
+LVTGGAGFIG+H V +L+ G++V ++D+L +E ++R E + EF GD
Sbjct: 9 ILVTGGAGFIGTHTVVQLLNQGFKVTIIDNLDNSVVEAVHRVRELVGPDLSTKLEFNLGD 68
Query: 57 MRDY----KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNV 112
+R+ K+ + + V H A V S +P ++ N++ T NL + + + N
Sbjct: 69 LRNKGDIEKLFSNQRNRFDAVIHFAGLKAVGESVGNPRRYFDNNLVGTINLYETMAKYNC 128
Query: 113 KFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFR 171
K +VF+SS+TVYG ++P E + L+ ++ YG KL E + +A ++ ++ R
Sbjct: 129 KMMVFSSSATVYGQPEIVPCVEDF-ELQAMNPYGRTKLFLEEIARDIHAAEPEWKIILLR 187
Query: 172 LANIIGKRSNHGV----------IYDFINKLK--RNPNELEILG------DGKQRKSYLH 213
N +G + + + +I ++ R P EL + G DG + Y+H
Sbjct: 188 YFNPVGAHESGRIGEDPKGIPNNLMPYIQQVAVGRLP-ELNVFGHDYPTMDGSAVRDYIH 246
Query: 214 VSDTINGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVD 272
V D +G + +KI YNLG +V E+ + G K
Sbjct: 247 VMDLADGHVAALNKLFSDSKIGCTAYNLGTGQGTSVLEMVSSFEKASGKKIPIKLC---- 302
Query: 273 GGRGWKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + S +KA K+ GW+ K E R
Sbjct: 303 --PRRAGDATAVYASTQKAEKELGWKAKYGVDEMCR 336
>gb|AAA57872.1| (U09349) UDP-glucose 4-epimerase [Azospirillum brasilense]
Length = 338
Score = 105 bits (259), Expect = 8e-22
Identities = 87/323 (26%), Positives = 143/323 (43%), Gaps = 35/323 (10%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
VLVTGGAG++GSH V L++ G+ V VLD+L G +R + F+ D+ D
Sbjct: 7 VLVTGGAGYVGSHCVAELLDRGFRVVVLDNLRQG-----HRVAVPSDAAFVEADLADMDA 61
Query: 63 VKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ + + VFH AA V S + P L N + + NL++A + V+ +VF+S+
Sbjct: 62 LTRVFAEWRFDAVFHFAALSLVGESMRDPHLYLHGNTVNSLNLIRAATTAGVRKMVFSST 121
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
+ ++G LP E ++P S YG +K E + G R+ R N G
Sbjct: 122 ANLFGTPERLPIDEE-TTIDPGSPYGESKFFIERALHWADRCHGLRSACLRYFNAAGAHP 180
Query: 181 NHGVIYDFINKLKRNP----------NELEILG------DGKQRKSYLHVSDTINGILHI 224
N + D + P + +EI G DG + Y+HV D + L +
Sbjct: 181 NGTLGEDHAPETHLIPLVLDAPAAGRSHIEIFGDDYPTADGTCVRDYIHVCDLADAHLRV 240
Query: 225 FEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFM 284
+ +++ +NLGN +V+E+ GL T V G GD +
Sbjct: 241 LPALETRSR----FNLGNGTGYSVREVIAATERVTGL------TVPVRVGPRRAGDPAVL 290
Query: 285 LLSIEKAK-KTGWRPKMNSYEAV 306
+ S E+ + + GW P+ +++
Sbjct: 291 IASSERIRGELGWSPRFPDLDSI 313
>gb|AAC38674.1| (AF030359) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804710|gb|AAC38695.1| (AF030363)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804723|gb|AAC38706.1| (AF030365)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804729|gb|AAC38711.1| (AF030366)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|3320401|gb|AAC38759.1| (AF030373)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|3818498|gb|AAC69540.1| (AF057294) Cps23fQ
[Streptococcus pneumoniae] >gi|4200435|gb|AAD10183.1|
(AF026471) Cps2N [Streptococcus pneumoniae]
Length = 349
Score = 105 bits (259), Expect = 8e-22
Identities = 91/324 (28%), Positives = 153/324 (47%), Gaps = 38/324 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
++VTGGAGFIGS+ V + E+ V VLD L+ AG+ N+ L N E + GD+ D
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGNR-VELVVGDIAD 65
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++V + + + H AA S P TN + TY LL+A R+ +++F S
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDIRF-HHVS 124
Query: 120 SSTVYGDANVLPTPESY-----GPLE---------PISVYGGAKLAAEALISGYAHIFGF 165
+ VYGD LP E GP E P S Y K A++ ++ + FG
Sbjct: 125 TDEVYGD---LPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGV 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRN---PNELEILGDGKQRKSYLHVSDTINGIL 222
+A I +N G + I FI + N + ++ G+GK + ++H +D +G+
Sbjct: 182 KATISNCSNNYGPYQH---IEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVW 238
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DV 281
I + +I + Y +G + KE+ E++ +EMG + D G D+
Sbjct: 239 TIL----TKGQIGETYLIGADGEKNNKEVLELILKEMG-----QAADAYDHVTDRAGHDL 289
Query: 282 KFMLLSIEKAKKTGWRPKMNSYEA 305
++ + + + + GW+P+ ++EA
Sbjct: 290 RYAIDASKLRDELGWKPEFTNFEA 313
>gb|AAC38679.1| (AF030360) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804697|gb|AAC38684.1| (AF030361)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804704|gb|AAC38690.1| (AF030362)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804716|gb|AAC38700.1| (AF030364)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
Length = 349
Score = 105 bits (259), Expect = 8e-22
Identities = 91/324 (28%), Positives = 153/324 (47%), Gaps = 38/324 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
++VTGGAGFIGS+ V + E+ V VLD L+ AG+ N+ L N E + GD+ D
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGNR-VELVVGDIAD 65
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++V + + + H AA S P TN + TY LL+A R+ +++F S
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDIRF-HHVS 124
Query: 120 SSTVYGDANVLPTPESY-----GPLE---------PISVYGGAKLAAEALISGYAHIFGF 165
+ VYGD LP E GP E P S Y K A++ ++ + FG
Sbjct: 125 TDEVYGD---LPLREDLLGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGV 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRN---PNELEILGDGKQRKSYLHVSDTINGIL 222
+A I +N G + I FI + N + ++ G+GK + ++H +D +G+
Sbjct: 182 KATISNCSNNYGPYQH---IEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVW 238
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DV 281
I + +I + Y +G + KE+ E++ +EMG + D G D+
Sbjct: 239 TIL----TKGQIGETYLIGADGEKNNKEVLELILKEMG-----QAADAYDHVTDRAGHDL 289
Query: 282 KFMLLSIEKAKKTGWRPKMNSYEA 305
++ + + + + GW+P+ ++EA
Sbjct: 290 RYAIDASKLRDELGWKPEFTNFEA 313
>gb|AAD19915.1| (AF105113) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
Length = 348
Score = 105 bits (259), Expect = 8e-22
Identities = 86/328 (26%), Positives = 155/328 (47%), Gaps = 31/328 (9%)
Query: 2 KVLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
K++VTGGAGFIGS+ V + + V VLD L+ AG+ N+ L + E + GD+
Sbjct: 6 KIIVTGGAGFIGSNFVHYVYNNFPDVHVTVLDKLTYAGNRANIEEIL-GDRVELVVGDIA 64
Query: 59 DYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
D +V + + + + H AA S P TN + TY LL+A R+ +++F
Sbjct: 65 DAALVDKLAAEADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDIRF-HHV 123
Query: 119 SSSTVYGDANVLPTPESYG-----------PLEPISVYGGAKLAAEALISGYAHIFGFRA 167
S+ VYGD + +G P S Y K A++ ++ + FG +A
Sbjct: 124 STDEVYGDLPLREDLPGHGEGLGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKA 183
Query: 168 LIFRLANIIGKRSNHGVIYDFINKLKRN---PNELEILGDGKQRKSYLHVSDTINGILHI 224
I +N G + I FI + N + ++ G+GK + ++H +D +G+ I
Sbjct: 184 TISNCSNNYGPYQH---IEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVWTI 240
Query: 225 FEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFM 284
+ +I + Y +G + KE+ E++ +EMG P + D D+++
Sbjct: 241 L----TKGQIGETYLIGADGEKNNKEVLELILKEMG-QPADAYDHVTDRA---GHDLRYA 292
Query: 285 LLSIEKAKKTGWRPKMNSYEA-VRRTVR 311
+ + + + GW+P+ ++EA ++ T++
Sbjct: 293 IDASKLRDELGWKPEFTNFEAGLKETIK 320
>emb|CAB44218.1| (AJ011653) UDP-galactose 4-epimerase [Lactococcus lactis]
Length = 326
Score = 105 bits (259), Expect = 8e-22
Identities = 79/278 (28%), Positives = 126/278 (44%), Gaps = 25/278 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M VLV GGAG++GSH VD L+ GY+V V+D+L G E + +E F GD+RD+
Sbjct: 1 MTVLVLGGAGYVGSHAVDMLVNRGYDVAVVDNLVTGHREAV-----SEKVRFYEGDVRDH 55
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ +++E + H A V S Q P + + NV +L+ + E VK +VF+
Sbjct: 56 AFLASVFEKENIEGIMHFCAYSLVGESMQKPLMYFNNNVGGAQVILETMEEFGVKHIVFS 115
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ +G P E P +PI+ YG +KL E ++ + + R N+ G
Sbjct: 116 STAATFGIPEESPISEK-TPQKPINPYGESKLIMEKMMKWQSQATDMTYVALRYFNVAGA 174
Query: 179 RSNHGVIYDFINKLKRNPNELE----------ILGDGKQR------KSYLHVSDTINGIL 222
+ + + N+ P L+ I GD Q + Y+ + D I +
Sbjct: 175 KDDGSIGEAHKNETHLIPIILQTALGQREFITIYGDDYQTPDGTCIRDYIDMEDLIEAHI 234
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMG 260
EY K K D +NLG+ + E+ E + G
Sbjct: 235 KALEYLKSGGK-SDQFNLGSSKGYSNLEVLETARKVTG 271
>sp|Q43070|GAE1_PEA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437228|pir||T06526 UDPglucose
4-epimerase (EC 5.1.3.2) - garden pea
>gi|1173555|gb|AAA86532.1| (U31544)
UDP-galactose-4-epimerase [Pisum sativum]
Length = 350
Score = 104 bits (258), Expect = 1e-21
Identities = 93/335 (27%), Positives = 154/335 (45%), Gaps = 37/335 (11%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE------NENFEFIRG 55
K+LVTG AGFIG+H V +L+ +G+ V ++D+ +E + R E ++N EF G
Sbjct: 7 KILVTGSAGFIGTHTVVQLLNNGFNVSIIDNFDNSVMEAVERVREVVGSNLSQNLEFTLG 66
Query: 56 DMRDYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
D+R+ +++ + + V H A V S ++P ++ N++ T NL + + + N K
Sbjct: 67 DLRNKDDLEKLFSKSKFDAVIHFAGLKAVGESVENPRRYFDNNLVGTINLYEVMAKHNCK 126
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRL 172
+VF+SS+TVYG +P E + L+ ++ YG KL E + +R ++ R
Sbjct: 127 KMVFSSSATVYGQPEKIPCVEDF-KLQAMNPYGRTKLFLEEIARDIQKAEPEWRIVLLRY 185
Query: 173 ANIIGKRSN-------HGV---IYDFINKLK--RNPNELEILG------DGKQRKSYLHV 214
N +G + G+ + +I ++ R P EL + G DG + Y+HV
Sbjct: 186 FNPVGAHESGKLGEDPRGIPNNLMPYIQQVAVGRLP-ELNVYGHDYPTRDGSAIRDYIHV 244
Query: 215 SDTING-ILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG 273
D +G I + + F +N YNLG +V E+ + G K
Sbjct: 245 MDLADGHIAALRKLFTSENIGCTAYNLGTGRGSSVLEMVAAFEKASGKKIALKLC----- 299
Query: 274 GRGWKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + S KA K+ GW+ K E R
Sbjct: 300 -PRRPGDATEVYASTAKAEKELGWKAKYGVEEMCR 333
>gb|AAC44971.1| (U09239) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
Length = 349
Score = 104 bits (258), Expect = 1e-21
Identities = 91/324 (28%), Positives = 153/324 (47%), Gaps = 38/324 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
++VTGGAGFIGS+ V + E+ V VLD L+ AG+ N+ L N E + GD+ D
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGNR-VELVVGDIAD 65
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++V + + + H AA S P TN + TY LL+A R+ +++F S
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDIRF-HHVS 124
Query: 120 SSTVYGDANVLPTPESY-----GPLE---------PISVYGGAKLAAEALISGYAHIFGF 165
+ VYGD LP E GP E P S Y K A++ ++ + FG
Sbjct: 125 TDEVYGD---LPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGV 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRN---PNELEILGDGKQRKSYLHVSDTINGIL 222
+A I +N G + I FI + N + ++ G+GK + ++H +D +G+
Sbjct: 182 KATISNCSNNYGPYQH---IEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVW 238
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DV 281
I + +I + Y +G + KE+ E++ +EMG + D G D+
Sbjct: 239 IIL----TKGQIGETYLIGADGEKNNKEVLELILKEMG-----QAADAYDHVTDRAGHDL 289
Query: 282 KFMLLSIEKAKKTGWRPKMNSYEA 305
++ + + + + GW+P+ ++EA
Sbjct: 290 RYAIDASKLRDELGWKPEFTNFEA 313
>pir||T51106 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated] -
Streptomyces antibioticus (ATCC 11891)
>gi|5902170|gb|AAD55454.1| (AF055579) dehydratase
[Streptomyces antibioticus]
Length = 335
Score = 104 bits (258), Expect = 1e-21
Identities = 94/319 (29%), Positives = 144/319 (44%), Gaps = 22/319 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMED---GYE----VRVLDDLS-AGSLENLNRWLENENFEF 52
M +LVTG AGFIGS V L+E G E + VLD L+ AG L N+ ++ F
Sbjct: 1 MNLLVTGAAGFIGSRYVHHLLEATRRGREPAPVITVLDKLTYAGVLGNVP---DDPAVTF 57
Query: 53 IRGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNV 112
+RGD+ D +V + + + V H AA V S SP TNVL T LL A V
Sbjct: 58 VRGDIADAPLVDSLMAEADQVVHFAAETHVDRSITSPGTFVRTNVLGTQVLLDAALRHGV 117
Query: 113 KFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRL 172
V S+ VYG PE + PL P S Y +K +++ L Y G + R
Sbjct: 118 GPFVHVSTDEVYGSIEHGSWPE-HQPLCPNSPYSASKASSDLLALSYHRTHGLDVRVTRC 176
Query: 173 ANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
+N G I + + + GDG + +LHV D G+ + + Q
Sbjct: 177 SNNYGPHQFPEKIVPLFVTNLLDGLRVPLYGDGLNVREWLHVDDHCLGV----DLVRTQG 232
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DVKFMLLSIEKA 291
+ +VY++G +T +++ ++ + G+ VD KG D ++ L + A
Sbjct: 233 RPGEVYHIGGGTELTNRDLTGLLLDAFGVG-----WDVVDPVADRKGHDRRYALDCAKAA 287
Query: 292 KKTGWRPKMNSYEAVRRTV 310
+ G+RP+ + E + RT+
Sbjct: 288 DELGYRPRRDFAEGIARTI 306
>emb|CAB61555.1| (AL133171) putative dehydratase [Streptomyces coelicolor A3(2)]
Length = 324
Score = 104 bits (257), Expect = 1e-21
Identities = 80/269 (29%), Positives = 124/269 (45%), Gaps = 14/269 (5%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY----EVRVLDDLS-AGSLENLNRWLENENFEFIRG 55
M +LVTG AGFIGS V L+ V VLD L+ AGS NL L + EF+ G
Sbjct: 1 MNILVTGAAGFIGSRYVRGLLASDAPGAPRVTVLDALTYAGSTANLE--LGHPRLEFVHG 58
Query: 56 DMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
D+RD +V + V H AA V S + TNV+ T NLL A V
Sbjct: 59 DIRDAALVDRLTAGADQVVHFAAESHVDRSIHAASDFVLTNVVGTQNLLDAALRHGVGPF 118
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
V S+ VYG + E + PL P S Y +K + + L Y G + R +N
Sbjct: 119 VHVSTDEVYGSVDAGSATEEH-PLRPSSPYSASKASGDLLALSYHRTHGLDVRVTRCSNN 177
Query: 176 IGKRS-NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
G ++ F+ +L + + + + GDG+ + +LHV D G+ + + + +
Sbjct: 178 YGPHQFPEKLVPLFVTRL-LDGHRVPLYGDGRNVRDWLHVDDHCRGV----DLVRTRGRA 232
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSP 263
+VYN+G ++ +++ ++ + G P
Sbjct: 233 GEVYNIGGGTELSNRDLTGLLLDACGAGP 261
>sp|O65780|GAE1_CYATE UDP-GLUCOSE 4-EPIMERASE GEPI42 (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437271|pir||T10496 UDPglucose
4-epimerase (EC 5.1.3.2) (clone GEPI42) - guar
>gi|3021355|emb|CAA06338.1| (AJ005081) UDP-galactose
4-epimerase [Cyamopsis tetragonoloba]
Length = 354
Score = 104 bits (256), Expect = 2e-21
Identities = 97/341 (28%), Positives = 152/341 (44%), Gaps = 51/341 (14%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRW------LENENFEFIRGD 56
+LVTGGAGFIGSH V +L++ G+ V ++D+L ++ ++R L + N F GD
Sbjct: 12 ILVTGGAGFIGSHTVVQLLKQGFHVSIIDNLYNSVIDAVHRVRLLVGPLLSSNLHFHHGD 71
Query: 57 MRDYKIVKEAVDDVEVVF---------HLAANPEVRISSQSPELLYETNVLITYNLLQAI 107
+R+ + D++++F H A V S +P Y+ N++ T NL Q +
Sbjct: 72 LRN-------IHDLDILFSKTKFDAVIHFAGLKGVGESVLNPSNYYDNNLVATINLFQVM 124
Query: 108 RESNVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFG-FR 166
+ N K LV +SS+TVYG + +P E L ++ YG +KL E + +R
Sbjct: 125 SKFNCKKLVISSSATVYGQPDQIPCVED-SNLHAMNPYGRSKLFVEEVARDIQRAEAEWR 183
Query: 167 ALIFRLANIIGKRSNHGV----------IYDFINK--LKRNPNELEILG------DGKQR 208
++ R N +G + + + +I + + R P EL I G DG
Sbjct: 184 IILLRYFNPVGAHESGQIGEDPRGLPNNLMPYIQQVAVARLP-ELNIYGHDYPTKDGTAI 242
Query: 209 KSYLHVSDTING-ILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKF 267
+ Y+HV D +G I + + F N YNLG +V E+ + G K
Sbjct: 243 RDYIHVMDLADGHIAALRKLFTTDNIGCTAYNLGTGRGTSVLEMVAAFEKASGKKIPIKM 302
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + S EKA K+ GW+ K E R
Sbjct: 303 C------PRRPGDATAVYASTEKAEKELGWKAKYGVEEMCR 337
>sp|O84903|GALE_LACCA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|3201657|gb|AAC19329.1| (AF005933)
UDP-galactose 4-epimerase [Lactobacillus casei]
Length = 331
Score = 104 bits (256), Expect = 2e-21
Identities = 87/331 (26%), Positives = 148/331 (44%), Gaps = 38/331 (11%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M + V GGAG+IGSH V +L+ G +V VLD+L G +R + F +GD+RDY
Sbjct: 1 MTIAVLGGAGYIGSHTVKQLLAAGEDVVVLDNLITG-----HRKAVDPRARFYQGDIRDY 55
Query: 61 KIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ + + + ++ + H AA V S + P ++ N LL+A+ + +K +VF+
Sbjct: 56 HFLSQVFSQEKIDGIVHFAAFSIVPESMKDPLKYFDNNTGGMITLLEAMNQFGIKKIVFS 115
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ YG+ +P E+ P P + YG +KLA E ++ +G + + R N+ G
Sbjct: 116 STAATYGEPKQVPIKET-DPQVPTNPYGESKLAMEKIMHWADVAYGLKFVALRYFNVAGA 174
Query: 179 RSNHGVIYDFINKLKRNPNELEILG----------------DGKQRKSYLHVSDTINGIL 222
+ + D + P L++ DG + Y+HV D + +
Sbjct: 175 MPDGSIGEDHHPETHIVPIILQVAAGTRTGLQIYGDDYPTKDGTNVRDYVHVVDLADAHI 234
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTG---GVDGGRGWKG 279
+Y NK +N+G+ + EI L+ K TG G G
Sbjct: 235 LALKYLDAGNK-SSAFNIGSAHGFSNLEI---------LNAARKVTGQEIPATMGPRRAG 284
Query: 280 DVKFMLLSIEKAKK-TGWRPKMNSYEAVRRT 309
D ++ S EKA+ GW+P + + + T
Sbjct: 285 DPSTLIASSEKARDILGWKPNYDDIDKIIET 315
>emb|CAA77209.1| (Y18523) dTDP-glucose 4,6-dehydratase [Actinoplanes sp. 50/110]
Length = 341
Score = 104 bits (256), Expect = 2e-21
Identities = 90/320 (28%), Positives = 147/320 (45%), Gaps = 21/320 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY-------EVRVLDDLS-AGSLENLNRWLENENFEF 52
MK+LVTGGAGFIGSH V L+ +V V+D L G+L NL + F F
Sbjct: 1 MKILVTGGAGFIGSHFVTSLISGDIATPQPVTQVTVVDKLGYGGNLRNLAEASADPRFSF 60
Query: 53 IRGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNV 112
+RGD+ D +++ + + V H AA V S + +N++ T LL A ++
Sbjct: 61 VRGDICDEGLIEGLMARHDTVAHFAAETHVDRSVVASGPFVASNLVGTQVLLDAALRHHI 120
Query: 113 KFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRL 172
+ S+ VYG + E + PL P S Y +K ++ L Y G ++ R
Sbjct: 121 GRFLHVSTDEVYGSIDTGSWAEGH-PLAPNSPYAASKAGSDLLALAYHQTHGMDVVVTRC 179
Query: 173 ANIIGKRS-NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQ 231
+N G R +I F+ +L + ++ + GDG+ + +LHVSD G+
Sbjct: 180 SNNYGPRQFPEKMIPLFVTRL-LDGLDVPVYGDGRNIRDWLHVSDHCRGLALAL----GA 234
Query: 232 NKIFDVYNLGNEDWITVKEIAEIVSEEMGL-SPKFKFTGGVDGGRGWKGDVKFMLLSIEK 290
+ +VY++G T E+ EI+ E G + F G D ++ L +
Sbjct: 235 GRAGEVYHIGGGWEATNLELTEILLEACGARRSRISFVTDRKG-----HDRRYSLDYSKI 289
Query: 291 AKKTGWRPKMNSYEAVRRTV 310
A + G+RP+++ + + TV
Sbjct: 290 AGELGYRPRVDFTDGIAETV 309
>gb|AAF59935.1| (AF237895) dTDP-D-glucose 4,6-dehydratase [Streptomyces
antibioticus]
Length = 335
Score = 104 bits (256), Expect = 2e-21
Identities = 91/319 (28%), Positives = 142/319 (43%), Gaps = 22/319 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE-------VRVLDDLS-AGSLENLNRWLENENFEF 52
M +LVTG AGFIGS V L+E + VLD L+ AG L N+ ++ F
Sbjct: 1 MNLLVTGAAGFIGSRYVHHLLEAARAGGEPAPVITVLDKLTYAGVLGNVP---DDPAVTF 57
Query: 53 IRGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNV 112
+RGD+ D +V + + + V H AA V S SP TNVL T LL A V
Sbjct: 58 VRGDIADAPLVDSLMAEADQVVHFAAESHVDRSITSPGTFVRTNVLGTQMLLDACLRHGV 117
Query: 113 KFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRL 172
V S+ VYG PE + PL P S Y +K +++ L Y G + R
Sbjct: 118 GPFVHVSTDEVYGSIEHGSWPE-HQPLCPNSPYSASKASSDLLALSYHRTHGLDVRVTRC 176
Query: 173 ANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
+N G + + + + GDG + +LHV D G+ + + Q
Sbjct: 177 SNNYGPHQFPEKLVPLFVTNLLDGLRVPLYGDGLNVREWLHVDDHCLGV----DLVRTQG 232
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DVKFMLLSIEKA 291
+ +VY++G +T +++ ++ + G+ VD KG D ++ L + A
Sbjct: 233 RPGEVYHIGGGTELTNRDLTGLLLDAFGVG-----WDVVDPVADRKGHDRRYALDCAKAA 287
Query: 292 KKTGWRPKMNSYEAVRRTV 310
+ G+RP+ + E + RT+
Sbjct: 288 DELGYRPRRDFAEGIARTI 306
>sp|P95780|RMLB_STRMU DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1813347|dbj|BAA11249.1| (D78182)
dTDP-glucose-4,6-dehydratase [Streptococcus mutans]
Length = 348
Score = 103 bits (255), Expect = 2e-21
Identities = 90/322 (27%), Positives = 153/322 (46%), Gaps = 36/322 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRV--LDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
++VTGGAGFIGS+ V + + +V V LD L+ AG+ NL L + E + GD+ D
Sbjct: 7 IIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNHANLEEIL-GDRVELVVGDIAD 65
Query: 60 YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++V + + + H AA S + P TN + TY LL+A R+ +++F S
Sbjct: 66 SELVDKLAAKADAIVHYAAESHNDNSLKDPSPFIYTNFVGTYTLLEAARKYDIRF-HHVS 124
Query: 120 SSTVYGDANVLPTPESY-----GPLE---------PISVYGGAKLAAEALISGYAHIFGF 165
+ VYGD LP E GP E P S Y K A++ ++ + FG
Sbjct: 125 TDEVYGD---LPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGV 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRN---PNELEILGDGKQRKSYLHVSDTINGIL 222
+A I +N G + I FI + N + ++ G+GK + ++H +D G+
Sbjct: 182 KATISNCSNNYGPYQH---IEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSTGVW 238
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVK 282
I + +I + Y +G + KE+ E++ E+M PK + D D++
Sbjct: 239 AIL----TKGRIGETYLIGADGEKNNKEVLELILEKMS-QPKDAYDHVTDRA---GHDLR 290
Query: 283 FMLLSIEKAKKTGWRPKMNSYE 304
+ + S + ++ GW+P+ ++E
Sbjct: 291 YAIDSTKLREELGWKPQFTNFE 312
>gb|AAC63021.1| (AF082008) UDP-galactose-4-epimerase [Lactococcus lactis]
Length = 326
Score = 103 bits (255), Expect = 2e-21
Identities = 78/278 (28%), Positives = 127/278 (45%), Gaps = 25/278 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M VLV GGAG++GSH VD L++ GY+V V+D+L G E++ N F GD+RD+
Sbjct: 1 MTVLVLGGAGYVGSHAVDMLLKRGYDVAVVDNLVTGHRESV-----PANVRFYEGDVRDH 55
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ +++E + H A V S Q P + + NV +L+ + E VK +VF+
Sbjct: 56 AFLASVFEKENIEGIMHFCAYSLVGESMQKPLMYFNNNVGGAQVILETMEEFGVKHIVFS 115
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ +G P E P +PI+ YG +KL E ++ + + R N+ G
Sbjct: 116 STAATFGIPEKSPISEK-TPQKPINPYGESKLIMEKMMKWQSQATDMTYVALRYFNVAGA 174
Query: 179 RSNHGVIYDFINKLKRNPNELE-ILG---------------DGKQRKSYLHVSDTINGIL 222
+ + + N+ P L+ LG DG + Y+ + D I +
Sbjct: 175 KDDGSIGEAHKNETHLIPIILQTALGQREFITIYGDDYHTPDGTCIRDYIDMEDLIEAHI 234
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMG 260
EY K + D +NLG+ + E+ E + G
Sbjct: 235 KALEYLKAGGQ-SDQFNLGSSKGYSNLEVLETARKVTG 271
>gb|AAD11505.1| (U60828) UDP-galactose-4-epimerase [Lactococcus lactis]
Length = 330
Score = 103 bits (255), Expect = 2e-21
Identities = 78/278 (28%), Positives = 127/278 (45%), Gaps = 25/278 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
M VLV GGAG++GSH VD L++ GY+V V+D+L G E++ N F GD+RD+
Sbjct: 5 MTVLVLGGAGYVGSHAVDMLLKRGYDVAVVDNLVTGHRESV-----PANVRFYEGDVRDH 59
Query: 61 KIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ +++E + H A V S Q P + + NV +L+ + E VK +VF+
Sbjct: 60 AFLASVFEKENIEGIMHFCAYSLVGESMQKPLMYFNNNVGGAQVILETMEEFGVKHIVFS 119
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGK 178
S++ +G P E P +PI+ YG +KL E ++ + + R N+ G
Sbjct: 120 STAATFGIPEKSPISEK-TPQKPINPYGESKLIMEKMMKWQSQATDMTYVALRYFNVAGA 178
Query: 179 RSNHGVIYDFINKLKRNPNELE-ILG---------------DGKQRKSYLHVSDTINGIL 222
+ + + N+ P L+ LG DG + Y+ + D I +
Sbjct: 179 KDDGSIGEAHKNETHLIPIILQTALGQREFITIYGDDYHTPDGTCIRDYIDMEDLIEAHI 238
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMG 260
EY K + D +NLG+ + E+ E + G
Sbjct: 239 KALEYLKAGGQ-SDQFNLGSSKGYSNLEVLETARKVTG 275
>pir||F82576 nucleotide sugar epimerase XF2279 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9107440|gb|AAF85078.1|AE004040_3
(AE004040) nucleotide sugar epimerase [Xylella
fastidiosa]
Length = 342
Score = 103 bits (254), Expect = 3e-21
Identities = 71/265 (26%), Positives = 122/265 (45%), Gaps = 5/265 (1%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENE---NFEFIRGDM 57
M VLVTG AGFIG+H+ L V LD+ +A L R + D+
Sbjct: 20 MTVLVTGAAGFIGAHVCRALAARNDTVVGLDNYNAYYDPQLKRDRVTALCPDVHIRTLDL 79
Query: 58 RDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
D + ++V+ V HLAA VR S ++P ++N++ N+L+ R V+ L
Sbjct: 80 TDRERCAALFNEVQPDQVVHLAAQAGVRYSIENPHAYVDSNLVGFLNVLELCRHCRVQHL 139
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
V+ SSS+VYGD+ P E +P S+YG K+A E + YA ++G RA R +
Sbjct: 140 VYASSSSVYGDSATPPFSEQQRVDQPRSLYGATKVANEVMAYSYAQLYGLRATGLRFFTV 199
Query: 176 IGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIF 235
G + ++ +E+ G+ + + ++D + G++ + Q
Sbjct: 200 YGPWGRPDMAPLIFSRAVLEGRPIEVFNHGRMERDFTFINDIVAGVIGALDAPGEQAVPH 259
Query: 236 DVYNLGNEDWITVKEIAEIVSEEMG 260
++NLGN + ++ ++ + G
Sbjct: 260 RLFNLGNHTPVPLEHFINVIEQAAG 284
>sp|Q05026|GALE_NEIGO UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|486715|pir||S34984 UDPglucose
4-epimerase (EC 5.1.3.2) - Neisseria gonorrhoeae
>gi|1051296|emb|CAA79721.1| (Z21508) UDP-glucose
4-epimerase [Neisseria gonorrhoeae]
Length = 338
Score = 102 bits (252), Expect = 5e-21
Identities = 88/287 (30%), Positives = 133/287 (45%), Gaps = 31/287 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL---SAGSLENLNRWLENENFEFIRGDM 57
M VL+TGG GFIGSH L++ GY+ +LD+L SA L L R + N F +GD+
Sbjct: 1 MTVLITGGTGFIGSHTAVSLVQSGYDAVILDNLCNSSAAVLPRL-RQITGRNIPFYQGDI 59
Query: 58 RDYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
RD +I+++ + +E V H A V S P Y NV + L + + + V +
Sbjct: 60 RDCQILRQIFSEHEIESVIHFAGLKAVGESVAEPTKYYGNNVYGSLVLAEEMARAGVLKI 119
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLAN 174
VF+SS+TVYGDA +P E P + + YG +K E +++ + ++ R N
Sbjct: 120 VFSSSATVYGDAEKVPYTEDMRPGDTANPYGASKAMVERMLTDIQKADPRWSVILLRYFN 179
Query: 175 IIGKRSNHGVIYDFINKLKRN------------PNELEILG------DGKQRKSYLHVSD 216
IG + G+I + N + N +L + G DG + Y+HV D
Sbjct: 180 PIGAHES-GLIGEQPNGVPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMD 238
Query: 217 TINGILHIFEYFKRQNKIFDV--YNLGNEDWITVKEIAEIVSEEMGL 261
G HI K + + V +NLG+ +V EI GL
Sbjct: 239 LAEG--HI-AAMKAKGGVAGVHLFNLGSGRAYSVLEIIRAFEAASGL 282
>pir||S62783 UDPglucose 4-epimerase (EC 5.1.3.2) - Arabidopsis thaliana
>gi|1143392|emb|CAA90941.1| (Z54214) uridine diphosphate
glucose epimerase [Arabidopsis thaliana]
Length = 351
Score = 102 bits (252), Expect = 5e-21
Identities = 90/334 (26%), Positives = 151/334 (44%), Gaps = 37/334 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE------NENFEFIRGD 56
+LVTGGAGFIG+H V +L++DG++V ++D+ +E ++R E ++ +F GD
Sbjct: 9 ILVTGGAGFIGTHTVVQLLKDGFKVSIIDNFDNSVIEAVDRVRELVGPDLSKKLDFNLGD 68
Query: 57 MRDYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+R+ +++ + + V H A V S + ++ N++ T NL + + + N K
Sbjct: 69 LRNKGDIEKLFSKQRFDAVIHFAGLKAVGESVEKGRRYFDNNLVGTINLYETMAKYNCKM 128
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLA 173
+VF+SS+TVYG +P E + L+ ++ YG KL E + +R ++ R
Sbjct: 129 MVFSSSATVYGQPEKIPCMEDF-ELKAMNPYGRTKLFLEEIARDIQKAEPEWRIILLRYF 187
Query: 174 NIIGKRSNHGV----------IYDFINKLK--RNPNELEILG------DGKQRKSYLHVS 215
N +G + + + +I ++ R P EL + G DG + Y+HV
Sbjct: 188 NPVGAHESGSIGEDPKGIPNNLMPYIQQVAVGRLP-ELNVYGHDYPTEDGSAVRDYIHVM 246
Query: 216 DTINGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGG 274
D +G + KI YNLG +V E+ + G K
Sbjct: 247 DLADGHIAALRKLFADPKIGCTAYNLGTGQGTSVLEMVAAFEKASGKKIPIKLC------ 300
Query: 275 RGWKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + S EKA K+ GW+ K E R
Sbjct: 301 PRRSGDATAVYASTEKAEKELGWKAKYGVDEMCR 334
>gb|AAD31800.1|AF128273_3 (AF128273) TDP-glucose-4,6-dehydratase homolog [Streptomyces
griseus]
Length = 324
Score = 102 bits (252), Expect = 5e-21
Identities = 88/319 (27%), Positives = 145/319 (44%), Gaps = 22/319 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY------EVRVLDDLS-AGSLENLNRWLENENFEFI 53
M++LVTGGAGFIGSH L+ Y + VLD L+ AG NL ++ EF+
Sbjct: 1 MRILVTGGAGFIGSHYARSLLAGRYGAAPDTRITVLDKLTYAGDRGNLPA--HHDRLEFV 58
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
RGD+ D +++E + + + H AA V S TN L T LL+A S V+
Sbjct: 59 RGDVCDGALLRELLPGHDAIVHFAAESHVDRSVAGGREFVRTNALGTQVLLEAASLSRVE 118
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
++ S+ VYG E PL P S Y +K +A+ + Y G I R +
Sbjct: 119 RVLHISTDEVYGSIEQGSWTEE-RPLLPNSPYAASKASADLIARSYWRTHGLDVSITRCS 177
Query: 174 NIIGKRSN-HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
N G + ++ F+ L R ++ + GDG+ R+ ++HV D I + +
Sbjct: 178 NNYGPYQHPEKLVPRFVTNLLRG-RKVPVYGDGRNRREWIHVDDHCRAIHLVL----AKG 232
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DVKFMLLSIEKA 291
++YN+G+ D + +AE + G ++ KG D+++ L +
Sbjct: 233 GAGEIYNVGSGDELENLRLAEHLLALCGADASM-----IEYVEDRKGHDLRYALDDTKIR 287
Query: 292 KKTGWRPKMNSYEAVRRTV 310
++ G+ P++ + TV
Sbjct: 288 EQLGYEPQVPLDRGIAETV 306
>pir||T48135 nucleotide sugar epimerase-like protein - Arabidopsis thaliana
>gi|5281036|emb|CAB45972.1| (AL080318) nucleotide sugar
epimerase-like protein [Arabidopsis thaliana]
>gi|7267926|emb|CAB78268.1| (AL161533) nucleotide sugar
epimerase-like protein [Arabidopsis thaliana]
Length = 436
Score = 102 bits (252), Expect = 5e-21
Identities = 89/335 (26%), Positives = 151/335 (44%), Gaps = 25/335 (7%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR----WLENENFEFIRGD 56
+ VLVTG +GF+G+H+ L G V LD+ + L R LE + GD
Sbjct: 96 LTVLVTGASGFVGTHVSIALRRRGDGVLGLDNFNRYYDPKLKRARQGLLERSGVFVVEGD 155
Query: 57 MRDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK- 113
+ D ++++ D V V HLAA VR + Q+P +N+ NLL+ + +N +
Sbjct: 156 INDAVLLRKLFDVVLFTHVMHLAAQAGVRYAMQNPGSYVNSNIAGFVNLLEVSKSANPQP 215
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+V+ SSS+VYG + +P E +P S+Y K A E + Y HI+G R
Sbjct: 216 AIVWASSSSVYGLNSKVPFSEKDRTDQPASLYAATKKAGEGIAHTYNHIYGLSLTGLRFF 275
Query: 174 NIIGKRSNHGVIYDFINK--LK-RNPNELEILGDGKQRKSYLHVSDTINGILHIFEYF-- 228
+ G + Y F K LK + E G + + ++ D + G L +
Sbjct: 276 TVYGPWGRPDMAYFFFTKDILKGKTITVFESPDKGSVARDFTYIDDIVKGCLGALDTAEK 335
Query: 229 -------KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDV 281
K+ +F +YNLGN + V ++ I+ + + + K K GDV
Sbjct: 336 STGSGGKKKGPAMFRIYNLGNTSPVPVTKLVTILEKLLKMKAKKKIM-----PLPRNGDV 390
Query: 282 KFMLLSIEKAK-KTGWRPKMNSYEAVRRTVRELLG 315
+F +I A+ + G++P ++ +++ V+ +G
Sbjct: 391 EFTHANITLAQAELGYKPAVDLETGLKKFVKWYMG 425
>pir||F82419 UDP-glucose 4-epimerase VCA0774 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9658197|gb|AAF96672.1| (AE004405)
UDP-glucose 4-epimerase [Vibrio cholerae]
Length = 338
Score = 102 bits (251), Expect = 7e-21
Identities = 92/326 (28%), Positives = 149/326 (45%), Gaps = 35/326 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE--NENFEFIRGDMR 58
MKVLVTGG G+IGSH ++++ G +LD+L + L+R + +F++GD+R
Sbjct: 1 MKVLVTGGMGYIGSHTCIQMIQAGMTPVILDNLYNSKVTVLDRIEKVIGVRPQFVQGDIR 60
Query: 59 DYKIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D ++ + + ++E V H A V S Q P Y+ NV T L+ A+RE+ VK LV
Sbjct: 61 DKALLVDLMQQHNIEAVVHFAGLKAVGESVQKPLEYYDNNVNGTLVLVAAMREAGVKSLV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYG+ +P ES+ P + + YG +KL E ++ + + + R N
Sbjct: 121 FSSSATVYGEPTSVPITESF-PTKAANPYGRSKLMVEECLTDFQKANPDWSITLLRYFNP 179
Query: 176 IGKRSN-------HGV---IYDFINKLKRNPNE-LEILG------DGKQRKSYLHVSDTI 218
+G + G+ + F+ ++ E L + G DG + Y+HV D
Sbjct: 180 VGSHPSGELGEDPQGIPNNLMPFVTQVAVGRREYLSVFGSDYPTKDGTGVRDYIHVMDLA 239
Query: 219 NGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDG--GR 275
+G HI K +YNLG +V ++ + G + +K G
Sbjct: 240 DG--HIAALKKVGTCAGLHIYNLGTGKGYSVLDVVKAFETASGRTVPYKLVDRRPGDIAE 297
Query: 276 GWKGDVKFMLLSIEKAKKTGWRPKMN 301
W K A+ GW+ N
Sbjct: 298 YWADPTK-------AAQDLGWKATRN 316
>pir||S70744 UDPglucose 4-epimerase (EC 5.1.3.2) - Yersinia enterocolitica
>gi|633700|emb|CAA87706.1| (Z47767) Uridine Diphosphate
Glucose Epimerase [Yersinia enterocolitica]
Length = 336
Score = 101 bits (250), Expect = 9e-21
Identities = 86/264 (32%), Positives = 128/264 (47%), Gaps = 25/264 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR--WLENENFEFIRGDMR 58
M +LVTGGAG+IGSH V L+E+G +V VLD+LS S E+L R + F +GD+
Sbjct: 1 MTILVTGGAGYIGSHTVLTLLENGEDVVVLDNLSNASAESLLRVSKITGRTPVFYQGDIL 60
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D +K+ + ++ V H A V S P Y+ NV + LL+ + S VK L+
Sbjct: 61 DRNCLKKIFFEHKIDSVIHFAGLKSVGESVVKPIEYYQNNVTGSIILLEEMVISGVKKLI 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHI---FGFRALIF--- 170
F+SS+TVYGD +P E + YG +K+ E ++ +A F RAL +
Sbjct: 121 FSSSATVYGDPEFVPLTEDARIGGTTNPYGSSKVMIEQILKDFAFAYPDFSIRALRYFNP 180
Query: 171 ---RLANIIGKRSN--HGVIYDFINKLKRNP-NELEILG------DGKQRKSYLHVSDTI 218
++ +IG+ N + FI ++ +L + G DG + Y+HV D
Sbjct: 181 VGAHISGLIGEDPNGKPNNLLPFITQVAIGKLPKLAVYGNDYPTVDGSGVRDYIHVMDLA 240
Query: 219 NGILHIFEYFKRQNKIFDVYNLGN 242
G L F VYNLG+
Sbjct: 241 EGHLCALNNLTHG---FKVYNLGS 261
>pir||T46572 probable UDP-glucuronic acid epimerase (EC 5.1.3.-) [imported] -
Sinorhizobium meliloti >gi|2959983|emb|CAA10917.1|
(AJ222661) UDP-glucuronic acid epimerase [Sinorhizobium
meliloti]
Length = 341
Score = 101 bits (250), Expect = 9e-21
Identities = 60/232 (25%), Positives = 120/232 (50%), Gaps = 9/232 (3%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS----AGSLENLNRWLENEN-FEFIRG 55
M+ L+TG AGFIG H+ RL+++G+ V D ++ E + L+ N F+ +
Sbjct: 1 MRYLITGTAGFIGFHVAKRLIDEGHFVVGFDGMTPYYDVTLKERRHAILQRSNGFKAVTA 60
Query: 56 DMRDYKIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
+ D + A + + EV+ HLAA VR S ++P+ + N++ ++N+L+ + K
Sbjct: 61 MLEDRAALDRAAELAEPEVIIHLAAQAGVRYSLENPKAYVDANLVGSWNMLELAKAIAPK 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
L+ S+S++YG +P E+ EP+++Y K + E + YAH++ FR
Sbjct: 121 HLMLASTSSIYGANEKIPFAEADRADEPMTLYAATKKSMELMAHSYAHLYKVPTTAFRFF 180
Query: 174 NIIGKRSNHGV-IYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHI 224
+ G + ++ F++ + N ++I G+G+ + + ++ D + I+ +
Sbjct: 181 TVYGPWGRPDMALFKFVDAI-HNGRPIDIYGEGRMSRDFTYIDDLVESIVRL 231
>gb|AAG21514.1|AC066689_8 (AC066689) UDP-galactose 4-epimerase, putative; 6572-4109
[Arabidopsis thaliana]
Length = 348
Score = 101 bits (250), Expect = 9e-21
Identities = 95/332 (28%), Positives = 148/332 (43%), Gaps = 35/332 (10%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLE-----NENFEFIRGDM 57
+LVTGGAG+IGSH V +L+ GY V+D+L SL ++ R + +N + D+
Sbjct: 5 ILVTGGAGYIGSHTVLQLLLGGYNTVVIDNLDNSSLVSIQRVKDLAGDHGQNLTVHQVDL 64
Query: 58 RDYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
RD +++ + + V H A V S P L Y N++ T LL+ + K L
Sbjct: 65 RDKPALEKVFSETKFDAVMHFAGLKAVGESVAKPLLYYNNNLIATITLLEVMAAHGCKKL 124
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAH-IFGFRALIFRLAN 174
VF+SS+TVYG +P E PL +S YG KL E + +R ++ R N
Sbjct: 125 VFSSSATVYGWPKEVPCTEE-SPLSGMSPYGRTKLFIEDICRDVQRGDPEWRIIMLRYFN 183
Query: 175 IIGKRSNHGV----------IYDFINK--LKRNPNELEILG------DGKQRKSYLHVSD 216
+G + + + ++ + + R PN L+I G DG + Y+HV D
Sbjct: 184 PVGAHPSGRIGEDPCGTPNNLMPYVQQVVVGRLPN-LKIYGTDYTTKDGTGVRDYIHVVD 242
Query: 217 TINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRG 276
+G + + +VYNLG TV E+ + + G+ V GR
Sbjct: 243 LADGHICALQKLDDTEIGCEVYNLGTGKGTTVLEMVDAFEKASGMKIPL-----VKVGRR 297
Query: 277 WKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + + S EKA ++ W+ E R
Sbjct: 298 -PGDAETVYASTEKAERELNWKANFGIEEMCR 328
>gb|AAD45555.1|U70376_20 (U70376) SpcJ [Streptomyces flavopersicus]
Length = 328
Score = 101 bits (249), Expect = 1e-20
Identities = 84/268 (31%), Positives = 120/268 (44%), Gaps = 14/268 (5%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVR------VLDDLS-AGSLENLNRWLENENFEFI 53
M++LVTGGAGFIGS V L+ R VLD L+ AG NL+ + + F+
Sbjct: 1 MRILVTGGAGFIGSEFVRSLLLTAEPERNTPWVTVLDKLTYAGVAANLDPVAGHPRYRFV 60
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
RGD+ D + + + V H AA V S TNV+ T +L A V
Sbjct: 61 RGDICDAHLADHVMRGHDAVVHFAAESHVDRSISGAGPFVTTNVVGTQVMLDAAYRHGVG 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
V S+ VYG + E PL+P S Y +K A+ L Y G ++ R +
Sbjct: 121 RFVQVSTDEVYGSISEGSWSEG-APLDPNSPYAASKAGADLLAHSYHRTHGMDVVVTRCS 179
Query: 174 NIIGKRS-NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
N G R VI FI L + E+ + GDG+ + +LHVSD GI R
Sbjct: 180 NNYGPRQFPEKVIPLFITNL-LDGREVPLYGDGQHMRDWLHVSDHCRGI----RLALRHG 234
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMG 260
K + Y++G +T + + ++ E G
Sbjct: 235 KAGETYHIGGGTELTNEALTGLLLEATG 262
>sp|O54067|LPSL_RHIME UDP-GLUCURONATE 5'-EPIMERASE (UDP-GLUCURONIC ACID EPIMERASE)
Length = 341
Score = 101 bits (249), Expect = 1e-20
Identities = 60/232 (25%), Positives = 120/232 (50%), Gaps = 9/232 (3%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS----AGSLENLNRWLENEN-FEFIRG 55
M+ L+TG AGFIG H+ RL+++G+ V D ++ E + L+ N F+ +
Sbjct: 1 MRYLITGTAGFIGFHVAKRLIDEGHFVVGFDGMTPYYDVTLKERRHAILQRSNGFKAVTA 60
Query: 56 DMRDYKIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
+ D + A + + EV+ HLAA VR S ++P+ + N++ ++N+L+ + K
Sbjct: 61 MLEDRAALDRAAELAEPEVIIHLAAQAGVRYSLENPKAYVDANLVGSWNMLELAKAIAPK 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
L+ S+S++YG +P E+ EP+++Y K + E + YAH++ FR
Sbjct: 121 HLMLASTSSIYGANEKIPFAEADRADEPMTLYAATKKSMELMAHSYAHLYKVPTTSFRFF 180
Query: 174 NIIGKRSNHGV-IYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHI 224
+ G + ++ F++ + N ++I G+G+ + + ++ D + I+ +
Sbjct: 181 TVYGPWGRPDMALFKFVDAI-HNGRPIDIYGEGRMSRDFTYIDDLVESIVRL 231
>sp|Q9T0A7|GAE3_ARATH PROBABLE UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437229|pir||T08911 UDPglucose
4-epimerase (EC 5.1.3.2) T32A16.90 - Arabidopsis
thaliana >gi|4972096|emb|CAB43892.1| (AL078468)
UDPglucose 4-epimerase-like protein [Arabidopsis
thaliana] >gi|7269241|emb|CAB81310.1| (AL161560)
UDPglucose 4-epimerase-like protein [Arabidopsis
thaliana]
Length = 350
Score = 101 bits (248), Expect = 2e-20
Identities = 97/333 (29%), Positives = 150/333 (44%), Gaps = 37/333 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDL---SAGSLENLNRWLENEN---FEFIRGD 56
VLVTGGAG+IGSH V +L+E GY V+D+ SA SL+ + + L EN F + D
Sbjct: 5 VLVTGGAGYIGSHTVLQLLEGGYSAVVVDNYDNSSAASLQRVKK-LAGENGNRLSFHQVD 63
Query: 57 MRDYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
+RD +++ + + V H A V S + P L Y N++ T LL+ + + K
Sbjct: 64 LRDRPALEKIFSETKFDAVIHFAGLKAVGESVEKPLLYYNNNIVGTVTLLEVMAQYGCKN 123
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLA 173
LVF+SS+TVYG +P E P+ + YG KL E + + ++ ++ R
Sbjct: 124 LVFSSSATVYGWPKEVPCTEE-SPISATNPYGRTKLFIEEICRDVHRSDSEWKIILLRYF 182
Query: 174 NIIGKRSNHGVIYDFIN------------KLKRNPNELEILG------DGKQRKSYLHVS 215
N +G + + D + + R P+ L + G DG + Y+HV
Sbjct: 183 NPVGAHPSGYIGEDPLGVPNNLMPYVQQVAVGRRPH-LTVFGTDYKTKDGTGVRDYIHVM 241
Query: 216 DTINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGR 275
D +G + +VYNLG + +V E+ + G K V GR
Sbjct: 242 DLADGHIAALRKLDDLKISCEVYNLGTGNGTSVLEMVAAFEKASG-----KKIPLVMAGR 296
Query: 276 GWKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + + S EKA ++ W+ K E R
Sbjct: 297 R-PGDAEVVYASTEKAERELNWKAKNGIEEMCR 328
>emb|CAA40568.1| (X57315) UDP-galactose-4-epimerase [Haemophilus influenzae]
Length = 338
Score = 100 bits (247), Expect = 2e-20
Identities = 85/290 (29%), Positives = 136/290 (46%), Gaps = 27/290 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR--WLENENFEFIRGDMR 58
M +LVTGGAG+IGSH V L+ G EV VLD+L S ++L R + + +F GD+
Sbjct: 1 MAILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D ++++ A +++ V H A V S Q P Y NV T L+Q ++++ V V
Sbjct: 61 DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD ++P E + YG +K E ++ A F I R N
Sbjct: 121 FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILRDTAKAEPKFSMTILRYFNP 180
Query: 176 IGKRSNHGVIYDFINKLKRN------------PNELEILG------DGKQRKSYLHVSDT 217
+G + G+I + N + N +L + G DG + Y+HV D
Sbjct: 181 VGAHES-GLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDL 239
Query: 218 INGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFK 266
G H+ + +N +YNLG +V ++ + + ++ +K
Sbjct: 240 AVG--HLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIPYK 287
>sp|P24325|GALE_HAEIN UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|1075413|pir||A64063 UDPglucose
4-epimerase (EC 5.1.3.2) - Haemophilus influenzae
(strain Rd KW20) >gi|1573321|gb|AAC22012.1| (U32719)
UDP-glucose 4-epimerase (galE) [Haemophilus influenzae
Rd]
Length = 338
Score = 100 bits (247), Expect = 2e-20
Identities = 85/290 (29%), Positives = 136/290 (46%), Gaps = 27/290 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR--WLENENFEFIRGDMR 58
M +LVTGGAG+IGSH V L+ G EV VLD+L S ++L R + + +F GD+
Sbjct: 1 MAILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLV 116
D ++++ A +++ V H A V S Q P Y NV T L+Q ++++ V V
Sbjct: 61 DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFV 120
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF-GFRALIFRLANI 175
F+SS+TVYGD ++P E + YG +K E ++ A F I R N
Sbjct: 121 FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILRDTAKAEPKFSMTILRYFNP 180
Query: 176 IGKRSNHGVIYDFINKLKRN------------PNELEILG------DGKQRKSYLHVSDT 217
+G + G+I + N + N +L + G DG + Y+HV D
Sbjct: 181 VGAHES-GLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDL 239
Query: 218 INGILHIFEYFKRQNKI-FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFK 266
G H+ + +N +YNLG +V ++ + + ++ +K
Sbjct: 240 AVG--HLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYK 287
>gb|AAF67513.1|AF170880_20 (AF170880) NovT [Streptomyces spheroides]
Length = 336
Score = 100 bits (247), Expect = 2e-20
Identities = 76/267 (28%), Positives = 119/267 (44%), Gaps = 12/267 (4%)
Query: 1 MKVLVTGGAGFIGSHLVDRLME------DGYEVRVLDDLS-AGSLENLNRWLENENFEFI 53
M++LVTGGAGFIGS V + G +V VLD L+ +G++ NL + N+ F+
Sbjct: 1 MRILVTGGAGFIGSEFVRATLRGTLPGSSGTQVTVLDKLTYSGNVLNLAPIADLRNYRFV 60
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
RGD+ D +V + V + + H AA V S S TN + T LL+A +
Sbjct: 61 RGDICDQDLVDDVVAGHDAIVHFAAETHVDRSIGSAASFVRTNAMGTQVLLEAASRHRLG 120
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
V S+ VYG E P+ P + Y AK A + L + G ++ R
Sbjct: 121 RFVHISTDEVYGSIPEGAWDEE-SPVAPNAPYAAAKAAGDLLALAWHRTHGLDVVVTRCT 179
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
N G + + ++ + G+G R+ +LHVSD I + +
Sbjct: 180 NNYGPYQYPEKLIPLFTTNVMDGQQVPVYGEGHNRRQWLHVSDHCRAI----QLVLLGGR 235
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMG 260
+VY++G +T E+AE + + G
Sbjct: 236 AGEVYHIGGGTELTNLELAEQILKSCG 262
>pir||S75783 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Synechocystis sp.
(strain PCC 6803) >gi|1001273|dbj|BAA10518.1| (D64003)
dTDP-glucose 4,6-dehydratase [Synechocystis sp.]
Length = 342
Score = 100 bits (246), Expect = 3e-20
Identities = 93/341 (27%), Positives = 154/341 (44%), Gaps = 50/341 (14%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVR--VLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
+LVTGGAGFIG++ V ++ + R VLD L+ AG+ L + NF F++GD+ D
Sbjct: 6 ILVTGGAGFIGANFVYHCVQTCGDRRIVVLDALTYAGNRATLAPLEKLPNFRFVQGDIGD 65
Query: 60 YKIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRE-------- 109
+V + + + +E + H AA V S P +TNV+ T+ LL+A RE
Sbjct: 66 RHLVDQLLREEQIETIAHFAAESHVDRSILGPGAFVQTNVVGTFTLLEAFREHWQRRGNP 125
Query: 110 SNVKFLVFTSSSTVYGDANVLPTPESYG-----PLEPISVYGGAKLAAEALISGYAHIFG 164
+ +FL S+ VYG TP G P P S Y +K ++ L+ Y H +G
Sbjct: 126 AQFRFL-HVSTDEVYGSL----TPNEPGFSETTPYSPNSPYSASKAGSDHLVRAYFHTYG 180
Query: 165 FRALIFRLANIIGKRSNHGVIYDFINKL-------KRNPNELEILGDGKQRKSYLHVSDT 217
LI +N G Y F KL +L + GDG+ + +L+V+D
Sbjct: 181 LPTLITNCSNNYGP-------YQFPEKLIPLMCLNILRGEKLPVYGDGQNVRDWLYVTDH 233
Query: 218 INGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSE-------EMGLSPKFKFTGG 270
+ + Q YN+G + + E+ EI+ + ++ + P +
Sbjct: 234 CQAL----DLVLHQALPGATYNIGGNNEVKNIELVEILCDLMDELAPDLPVKPARQLISY 289
Query: 271 VDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
V G D ++ + + + ++ GW PK+ +R+TV+
Sbjct: 290 VTDRPG--HDRRYAIDASKIKRELGWEPKVTVERGLRQTVQ 328
>pir||S74768 UDPglucose 4-epimerase (EC 5.1.3.2) - Synechocystis sp. (strain
PCC 6803) >gi|1651993|dbj|BAA16919.1| (D90901)
UDP-glucose 4-epimerase [Synechocystis sp.]
Length = 340
Score = 100 bits (246), Expect = 3e-20
Identities = 91/330 (27%), Positives = 150/330 (44%), Gaps = 39/330 (11%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
K+LVTGGAG+IGS +V +L E GY + V D+ S G ++ + + GD+ D +
Sbjct: 8 KILVTGGAGYIGSSVVRQLGEAGYSIVVYDNCSTGFPSSILYG------QLVIGDLADTE 61
Query: 62 IVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
+ + + E+ V H A + V S P Y N T +L++ + V L+F+S
Sbjct: 62 RLHQVFHEHEILAVMHFAGSLIVPESLIHPLNYYANNTSNTLSLIRCCQIFGVNRLIFSS 121
Query: 120 SSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG-- 177
++ VYG+++ P E+ P PI+ YG +KLA+E +I YA + +I R N+ G
Sbjct: 122 TAAVYGNSSSNPISEAEIPC-PINPYGRSKLASEWIIQDYAKSSALQYVILRYFNVAGAD 180
Query: 178 ---------KRSNHGV--IYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTING 220
K + H V + D I LK + L+I G DG + Y+HV D
Sbjct: 181 PEGRLGQMSKTTTHLVRSVCDAILNLKPS---LDIFGTDFPTRDGTAVRDYIHVEDLAKA 237
Query: 221 ILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGD 280
L Y + + + N G +V+E+ + G+ + T GD
Sbjct: 238 HLDALRYLENGGE-SQILNCGYGQGYSVREVVDRAKAISGVDFLVRET------ERRLGD 290
Query: 281 VKFMLLSIEKAKKT-GWRPKMNSYEAVRRT 309
++ + ++ W PK N+ + + RT
Sbjct: 291 PASVIACADSIRQVLNWTPKYNNLDIILRT 320
>emb|CAB79762.1| (AL161577) nucleotide sugar epimerase-like protein [Arabidopsis
thaliana]
Length = 429
Score = 100 bits (246), Expect = 3e-20
Identities = 88/332 (26%), Positives = 148/332 (44%), Gaps = 27/332 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR----WLENENFEFIRGD 56
+ VLVTG GF+GSH+ L + G V LD+ + +L R L + + GD
Sbjct: 88 ISVLVTGATGFVGSHVSLALRKRGDGVVGLDNFNNYYDPSLKRARRSLLSSRGIFVVEGD 147
Query: 57 MRDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK- 113
+ D K++ + D V V HLAA VR + ++P+ +N+ NLL+ + +N +
Sbjct: 148 LNDAKLLAKLFDVVAFTHVMHLAAQAGVRYALENPQSYVHSNIAGLVNLLEICKAANPQP 207
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+V+ SSS+VYG +P ES +P S+Y K A E + Y HI+G R
Sbjct: 208 AIVWASSSSVYGLNEKVPFSESDRTDQPASLYAATKKAGEEITHTYNHIYGLAITGLRFF 267
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQR----KSYLHVSDTINGILHIFEYF- 228
+ G + Y + + I GK R + + ++ D + G L +
Sbjct: 268 TVYGPWGRPDMAYFSFTRNILQGKPITIY-RGKNRVDLARDFTYIDDIVKGCLGSLDSSG 326
Query: 229 --------KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGD 280
KR + ++NLGN +TV + +I+ + + + K F GD
Sbjct: 327 KSTGSGGKKRGAAPYRIFNLGNTSPVTVPILVDILEKHLKVKAKRNFV-----EMPGNGD 381
Query: 281 VKFMLLSIEKAK-KTGWRPKMNSYEAVRRTVR 311
V F +I A+ + G++P + +++ VR
Sbjct: 382 VPFTHANISSARNEFGYKPTTDLETGLKKFVR 413
>pir||H64564 UDP-glucose 4-epimerase - Helicobacter pylori (strain 26695)
>gi|2313462|gb|AAD07428.1| (AE000553) UDP-glucose
4-epimerase [Helicobacter pylori 26695]
Length = 344
Score = 99.8 bits (245), Expect = 4e-20
Identities = 79/289 (27%), Positives = 137/289 (47%), Gaps = 36/289 (12%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE-VRVLDDLSAGSLENLNRWLEN---ENFEFIRGD 56
M +L TG G+IGSH +E E + ++DDLS G LE+L LE+ FI+ +
Sbjct: 1 MALLFTGACGYIGSHTARAFLEKTKENIIIVDDLSTGFLEHLKA-LEHYYPNRVVFIQAN 59
Query: 57 MRD------YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRES 110
+ + + ++ D +E + H A V S+ P Y N L T L++ +
Sbjct: 60 LNETHKLDAFLNKQQLKDPIEAILHFGAKISVEESTHLPLEYYTNNTLNTLELVKLCLKH 119
Query: 111 NVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIF 170
+K +F+S++ VYG+++ ES PL PI+ YG +K+ +E ++ + I F+ +I
Sbjct: 120 AIKRFIFSSTAVVYGESSSSLNEES--PLNPINPYGASKMMSERILLDTSKIADFKCVIL 177
Query: 171 RLANIIG--KRSNHGVIYDFINKLKRNPNELEILGD---GKQRK---------------- 209
R N+ G +++ Y + + ++I + GK++K
Sbjct: 178 RYFNVAGACMHNDYTTPYTLGQRTLNATHLIKIACECAVGKRKKMGIFGTNYPTRDGTCI 237
Query: 210 -SYLHVSDTINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSE 257
Y+HV D N L ++ +NK ++YN+G +VKE+ E V E
Sbjct: 238 RDYIHVDDLANAHLASYQTLLEKNK-SEIYNVGYNQGHSVKEVIEKVKE 285
>pir||G71858 udp-glucose 4-epimerase - Helicobacter pylori (strain J99)
>gi|4155609|gb|AAD06600.1| (AE001530) UDP-GLUCOSE
4-EPIMERASE [Helicobacter pylori J99]
Length = 344
Score = 99.8 bits (245), Expect = 4e-20
Identities = 79/289 (27%), Positives = 137/289 (47%), Gaps = 36/289 (12%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE-VRVLDDLSAGSLEN---LNRWLENENFEFIRGD 56
M +L TG G+IGSH +E E + ++DDLS G LE+ L R+ N FI+ +
Sbjct: 1 MALLFTGACGYIGSHTARVFLEKTKENIIIIDDLSTGFLEHIKALERYYPNR-VAFIQAN 59
Query: 57 MRDYKIV------KEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRES 110
+ + + + ++ D +E V H A V S + P Y N L T L++ +
Sbjct: 60 LNETQKLDAFLNKQQLKDPIEAVLHFGAKISVEESMRLPLEYYTNNTLNTLGLVKLCLKH 119
Query: 111 NVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIF 170
+K +F+S++ VYG++ + ES PL PI+ YG +K+ +E ++ + + F+ +I
Sbjct: 120 AIKRFIFSSTAVVYGESGSSLSEES--PLNPINPYGASKMMSERILLDASKVADFKCVIL 177
Query: 171 RLANIIG--KRSNHGVIYDFINKLKRNPNELEILGD---GKQRK---------------- 209
R N+ G +++ Y + + ++I + GK++K
Sbjct: 178 RYFNVAGACMHNDYTTPYTLGQRTLNATHLIKIACECAVGKRKKMGIFGTNYPTRDGTCI 237
Query: 210 -SYLHVSDTINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSE 257
Y+HV D N L + +NK ++YN+G +VKE+ E V E
Sbjct: 238 RDYIHVDDLANAHLASYHTLLEKNK-SEIYNVGYNQGHSVKEVIEKVKE 285
>gb|AAF76478.1|AC020622_12 (AC020622) Contains similarity to CAPI protein from Staphylococcus
aureus gi|P39858 and contains a NAD dependent
epimerase/dehydratase PF|01370 domain. ESTs gb|N97076,
gb|AI997010 come from this gene. [Arabidopsis thaliana]
Length = 434
Score = 99.8 bits (245), Expect = 4e-20
Identities = 89/335 (26%), Positives = 145/335 (42%), Gaps = 25/335 (7%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR----WLENENFEFIRGD 56
+ VLVTG AGF+G+H+ L G V LD+ + +L R LE + GD
Sbjct: 92 VSVLVTGAAGFVGTHVSAALKRRGDGVLGLDNFNDYYDTSLKRSRQALLERSGVFIVEGD 151
Query: 57 MRDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK- 113
+ D ++K+ + V V HLAA VR + ++P +N+ NLL+ + +N +
Sbjct: 152 INDLSLLKKLFEVVPFTHVMHLAAQAGVRYAMENPGSYVHSNIAGFVNLLEVCKSANPQP 211
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+V+ SSS+VYG +P E +P S+Y K A E + Y HI+G R
Sbjct: 212 AIVWASSSSVYGLNTKVPFSEKDRTDQPASLYAATKKAGEEIAHTYNHIYGLSLTGLRFF 271
Query: 174 NIIGKRSNHGVIYDFINK--LKRNPNEL-EILGDGKQRKSYLHVSDTINGILHIFEYF-- 228
+ G + Y F + LK + E G + + ++ D + G L +
Sbjct: 272 TVYGPWGRPDMAYFFFTRDILKGKAISIFEGANHGTVARDFTYIDDIVKGCLGALDTAEK 331
Query: 229 -------KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDV 281
KR V+NLGN + V ++ I+ + + K GDV
Sbjct: 332 STGSGGKKRGAAQLRVFNLGNTSPVPVTDLVSILERLLKVKAKRNMM-----KLPRNGDV 386
Query: 282 KFMLLSIEKAKKT-GWRPKMNSYEAVRRTVRELLG 315
F +I A++ G++P + +++ VR LG
Sbjct: 387 PFTHANISSAQREFGYKPSTDLQTGLKKFVRWYLG 421
>gb|AAB82632.1| (AC002387) putative nucleotide sugar epimerase [Arabidopsis
thaliana]
Length = 437
Score = 99.5 bits (244), Expect = 5e-20
Identities = 89/329 (27%), Positives = 144/329 (43%), Gaps = 25/329 (7%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLD---DLSAGSLENLNR-WLENENFEFIRGDMR 58
VLVTG AGF+G+H+ L G V LD D SL+ R LE + GD+
Sbjct: 99 VLVTGAAGFVGTHVSAALKRRGDGVIGLDNFNDYYDPSLKRARRALLERSGIFIVEGDIN 158
Query: 59 DYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK-FL 115
D +++++ V V HLAA VR + ++P +N+ NLL+ + N + +
Sbjct: 159 DVELLRKLFKIVSFTHVMHLAAQAGVRYAMENPSSYVHSNIAGFVNLLEICKSVNPQPAI 218
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
V+ SSS+VYG +P E +P S+Y K A E + Y HI+G R +
Sbjct: 219 VWASSSSVYGLNTKVPFSEKDKTDQPASLYAATKKAGEEIAHTYNHIYGLSLTGLRFFTV 278
Query: 176 IGKRSNHGVIYDFINK--LK-RNPNELEILGDGKQRKSYLHVSDTINGILHIFEYF---- 228
G + Y F K LK ++ + E G + + ++ D + G L +
Sbjct: 279 YGPWGRPDMAYFFFTKDILKGKSISIFESANHGTVARDFTYIDDIVKGCLAALDTAEKST 338
Query: 229 -----KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKF 283
KR V+NLGN + V ++ I+ ++ + K GDV F
Sbjct: 339 GSGGKKRGPAQLRVFNLGNTSPVPVSDLVRILERQLKVKAKKNLI-----KMPRNGDVPF 393
Query: 284 MLLSIEKA-KKTGWRPKMNSYEAVRRTVR 311
+I A ++ G++P + +++ VR
Sbjct: 394 THANISLAQRELGYKPTTDLQTGLKKFVR 422
>gb|AAF01814.1|AF187532_10 (AF187532) putative dTDP-glucose-4,6-dehydratase [Streptomyces
nogalater]
Length = 350
Score = 99.5 bits (244), Expect = 5e-20
Identities = 89/321 (27%), Positives = 148/321 (45%), Gaps = 21/321 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMED--------GYEVRVLDDLS-AGSLENLNRWLENENFE 51
+ +LVTG GFIGS V L+E+ V VLD L+ AG+L NL+ + +
Sbjct: 11 VNILVTGAVGFIGSAYVRMLLENRAPGAGAPAVRVTVLDKLTYAGNLTNLDA-VRGDRLR 69
Query: 52 FIRGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESN 111
F+RGD+ D ++V E + + V H AA V S ++ + TNV+ T LL A
Sbjct: 70 FVRGDILDAELVDELMAHSDQVVHFAAESHVDRSIRAADDFVLTNVVGTQRLLDAALRHG 129
Query: 112 VKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFR 171
V+ V S+ VYG PE + PL P S Y +K +A+ + G + R
Sbjct: 130 VEPFVLVSTDEVYGSIASGSWPEEH-PLSPNSPYAASKASADLMAFACHRTHGLDVRVTR 188
Query: 172 LANIIGKRSN-HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKR 230
+N G R + +I F+ L + + + GDG+ + +LHV D G+ + +
Sbjct: 189 CSNNYGPRQHPEKLIPRFVTNL-LDGLPVPLYGDGRNVREWLHVEDHCRGV----DLVRT 243
Query: 231 QNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEK 290
+ VY++G ++ +E+ ++ E G + V +G D+++ L
Sbjct: 244 AGRPGGVYHIGGGRELSNRELVGMLLELCGAD--WSSVRHVPDRKG--HDLRYSLDWGRA 299
Query: 291 AKKTGWRPKMNSYEAVRRTVR 311
++ G+RP +R TV+
Sbjct: 300 REELGYRPAREFSSGLRSTVQ 320
>gb|AAC35922.1| (AF071085) putative dTDP-glucose-4,6-dehydratase [Enterococcus
faecalis]
Length = 342
Score = 98.7 bits (242), Expect = 8e-20
Identities = 86/333 (25%), Positives = 155/333 (45%), Gaps = 41/333 (12%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRV--LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
K++VTGGAGFIGS+ V ++++ EV V LD L+ AG+ +NL + ++ E + GD+
Sbjct: 3 KIIVTGGAGFIGSNFVHYVVKNHPEVHVTVLDKLTYAGNEKNLEG-IPSDRVELVVGDIV 61
Query: 59 DYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
D ++V V + + V H A S P +TN++ TY L++A R++NV++
Sbjct: 62 DAELVNRLVAETDAVVHYAXESHNDNSLNDPFPFVQTNLIGTYTLIEACRKNNVRY-HHV 120
Query: 119 SSSTVYGDANVLPTPESYG-----------PLEPISVYGGAKLAAEALISGYAHIFGFRA 167
S+ VYGD + +G P P S Y K ++ L+ + F +A
Sbjct: 121 STDEVYGDLPLREDLPGHGEGEGEKFTAETPYNPSSPYSSTKAGSDLLVKAWVRSFNLQA 180
Query: 168 LIFRLANIIGKRSNHGVIYDFINKL--KRNPNEL-----EILGDGKQRKSYLHVSDTING 220
I +N G Y I K ++ N L ++ G GK + ++H +D +
Sbjct: 181 TISNCSNNYGP-------YQHIEKFIPRQITNVLSGITPKLYGAGKNVRDWIHTNDHSSA 233
Query: 221 ILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLS-PKFKFTGGVDGGRGWKG 279
+ I + +I + Y +G + K + E++ E MG ++ G
Sbjct: 234 VWAIL----TKGQIGETYLIGADGEEDNKTVMELILELMGQPVDAYEHVNDRVG-----H 284
Query: 280 DVKFMLLSIEKAKKTGWRPKMNSY-EAVRRTVR 311
D+++ + S ++ GW P+ ++ E + T++
Sbjct: 285 DLRYAIDSTRLREELGWEPEFTNFREGLAETIK 317
>gb|AAD12971.1| (AF078135) RmlB [Leptospira borgpetersenii]
Length = 349
Score = 98.7 bits (242), Expect = 8e-20
Identities = 92/331 (27%), Positives = 153/331 (45%), Gaps = 33/331 (9%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDG--YEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
K+LVTGGAGFIGS+ V+ ++ + Y++ V D L+ AG+L++L W ++ F FI+ D+
Sbjct: 3 KILVTGGAGFIGSNFVNLILNENEEYQIIVFDKLTYAGNLKSLEYWKKDPRFIFIKADIA 62
Query: 59 D----YKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-----E 109
+ + I +E + + V H AA V S PE +TNVL T+ LL A R
Sbjct: 63 NKENVFSIFQE--HNFDYVAHFAAESHVDRSILGPEEFIKTNVLGTFYLLDAARLQWNGS 120
Query: 110 SNVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALI 169
K + S+ V+G P P S Y +K ++ ++ Y H + +
Sbjct: 121 YEGKKFLHVSTDEVFGTLGDTGYFTEETPYAPNSPYSASKAGSDHIVRSYYHTYHMPVVT 180
Query: 170 FRLANIIGKR--SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGI-LHIFE 226
+N G + +N L+ P L + GDGK + +L+V D + L +F
Sbjct: 181 TNCSNNYGPYHFPEKLIPLTILNCLQGKP--LPVYGDGKNIRDWLYVKDHCEALRLALF- 237
Query: 227 YFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGG-----VDGGRGWKG-D 280
Q + YN+G + K+ +IV+ + +F +G + + G D
Sbjct: 238 ----QGLPGETYNIGTRN---EKKNIDIVNSICSIMDEFHPSGVPHSKLIQYVKDRPGHD 290
Query: 281 VKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
++ + + K+ GW+PK A+R TVR
Sbjct: 291 FRYAIDPSKIEKELGWKPKFVFESALRETVR 321
>pir||T01339 hypothetical protein F6N15.16 - Arabidopsis thaliana
>gi|3193316|gb|AAC19298.1| (AF069299) contains
similarity to nucleotide sugar epimerases [Arabidopsis
thaliana] >gi|7267098|emb|CAB80769.1| (AL161471)
putative nucleotide sugar epimerase [Arabidopsis
thaliana]
Length = 430
Score = 98.3 bits (241), Expect = 1e-19
Identities = 88/333 (26%), Positives = 145/333 (43%), Gaps = 25/333 (7%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR----WLENENFEFIRGDMR 58
VLVTG AGF+G+H+ L G V LD+ + +L R LE + GD+
Sbjct: 93 VLVTGAAGFVGTHVSAALKRRGDGVLGLDNFNDYYDPSLKRARQALLERSGVFVVEGDIN 152
Query: 59 DYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK-FL 115
D ++K+ + V V HLAA VR + ++P +N+ NLL+ + +N + +
Sbjct: 153 DAALLKKLFEVVPFTHVMHLAAQAGVRYAMENPSSYVHSNIAGFVNLLEVCKSANPQPAI 212
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANI 175
V+ SSS+VYG +P E +P S+Y K A E + Y HI+G R +
Sbjct: 213 VWASSSSVYGLNTKVPFSEKDRTDQPASLYAATKKAGEEIAHTYNHIYGLSLTGLRFFTV 272
Query: 176 IGKRSNHGVIYDFINK--LKRNPNEL-EILGDGKQRKSYLHVSDTINGILHIFEYF---- 228
G + Y F + LK + E + G + + ++ D + G L +
Sbjct: 273 YGPWGRPDMAYFFFTRDILKGKAISIFEGVNHGTVARDFTYIDDIVKGCLGALDTAEKST 332
Query: 229 -----KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKF 283
KR V+NLGN + V ++ I+ + + K GDV+F
Sbjct: 333 GSGGKKRGAAQLRVFNLGNTSPVPVTDLVTILERLLKVKAKRNIM-----KLPRNGDVQF 387
Query: 284 MLLSIEKA-KKTGWRPKMNSYEAVRRTVRELLG 315
+I A ++ G++P + +++ R LG
Sbjct: 388 THANISSAQRELGYKPTTDLQTGLKKFARWYLG 420
>gb|AAB47842.1| (U61226) RfbB [Leptospira interrogans]
>gi|5814320|gb|AAD52188.1|AF144879_27 (AF144879) unknown
[Leptospira interrogans]
Length = 349
Score = 97.9 bits (240), Expect = 1e-19
Identities = 91/328 (27%), Positives = 147/328 (44%), Gaps = 27/328 (8%)
Query: 2 KVLVTGGAGFIGSHLVDRLMED--GYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
K+LVTGGAGFIGS+ V+ ++ D Y+V V D L+ AG+L +L W ++ F F++ D+
Sbjct: 3 KILVTGGAGFIGSNFVNLILNDTKEYQVVVFDKLTYAGNLRSLESWKKDSRFIFVKADIA 62
Query: 59 DYKIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-----ESN 111
+ + V + + H AA V S PE +TNVL T+ LL A R
Sbjct: 63 NKEEVSSIFQEHKFNYIAHFAAESHVDRSISGPEEFIKTNVLGTFYLLDAARLQWNGSYE 122
Query: 112 VKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFR 171
K + S+ V+G P P S Y +K +++ ++ Y H + +
Sbjct: 123 GKKFLHVSTDEVFGTLGDSGYFTEETPYAPNSPYSASKASSDHIVRSYYHTYHMPVVTTN 182
Query: 172 LANIIGKR--SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGI-LHIFEYF 228
+N G + +N L+ P L + GDGK + +L+V D + + +F
Sbjct: 183 CSNNYGPYHFPEKLIPLMILNCLQGKP--LPVYGDGKNIRDWLYVKDHCEALRVALF--- 237
Query: 229 KRQNKIFDVYNLG----NEDWITVKEIAEIVSE-EMGLSPKFKFTGGVDGGRGWKGDVKF 283
Q + YN+G ++ V I I+ E +P K V G D ++
Sbjct: 238 --QGLPGETYNIGTRNEKKNIDIVDSICSIMDELHPSGAPHSKLIQYVKDRPG--HDFRY 293
Query: 284 MLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
+ + K+ GW+PK A++ TVR
Sbjct: 294 AIDPSKIEKELGWKPKFAFESALKETVR 321
>gb|AAD31797.1|AF128272_2 (AF128272) TDP-glucose-4,6-dehydratase [Streptomyces spectabilis]
Length = 330
Score = 97.9 bits (240), Expect = 1e-19
Identities = 96/329 (29%), Positives = 143/329 (43%), Gaps = 41/329 (12%)
Query: 1 MKVLVTGGAGFIGSHLVDRLM-----EDGYEVRVLDDLS-AGSLENLNRWLENENFEFIR 54
M+++VTGGAGFIGS V ++ + + VLD L+ AG ENL+ + F+
Sbjct: 1 MRIIVTGGAGFIGSEFVRSMLLAPGAANDIRITVLDKLTYAGVRENLDPVAGHPRHAFVH 60
Query: 55 GDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
GD+ D + + V + V H AA V S TNVL T LL A R V
Sbjct: 61 GDICDGDFLDQVVPGHDAVVHFAAETHVDRSITGSAPFVTTNVLGTQLLLDAARRHGVGR 120
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLAN 174
+ S+ VYG V E PL P S Y K +E L G ++ R +N
Sbjct: 121 FLHVSTDEVYGSIPVGSWSEE-SPLAPNSPYAATKAGSELLALACHRTHGMDVVVTRCSN 179
Query: 175 IIGK-RSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNK 233
G + VI FI +L + ++ + GDG+ + +LHVSD G+ E R +
Sbjct: 180 NYGPYQFPEKVIPLFITRL-LDGGKVPLYGDGQHVRDWLHVSDHCRGV----ELALRHGR 234
Query: 234 IFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGV--DGGRGW---------KG-DV 281
+VY++G E+ +E++ TG + GRGW KG D
Sbjct: 235 AGEVYHIGGG--------TELTNEQL--------TGHLLAATGRGWEQVERVPDRKGHDA 278
Query: 282 KFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
++ L + A + G+ P + + TV
Sbjct: 279 RYSLDCTKAATELGYAPLVGFERGLADTV 307
>sp|Q59745|EXOB_RHILT UDP-GLUCOSE 4-EPIMERASE (UDP-GALACTOSE 4-EPIMERASE)
(GALACTOWALDENASE) >gi|1360122|emb|CAA65359.1| (X96507)
UDP-glucose 4-epimerase [Rhizobium leguminosarum]
Length = 327
Score = 97.1 bits (238), Expect = 2e-19
Identities = 91/325 (28%), Positives = 136/325 (41%), Gaps = 35/325 (10%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
VLV GGAG+IGSH L GY V D+ S G E + RW E GD+RD
Sbjct: 6 VLVVGGAGYIGSHTCLDLANKGYRPVVFDNFSNGHREFV-RWGPAEE-----GDIRDRAR 59
Query: 63 VKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
+ E A + H AA EV S + P YE NV+ T LL A + + + VF+S+
Sbjct: 60 LDEVLAKHKPAAILHFAALIEVGESVKDPVSFYENNVIGTLTLLSAAQAAGINAFVFSST 119
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG--- 177
YG +P E++ + PI+ YG K E ++ Y R+++ R N G
Sbjct: 120 CATYGLPQSVPLDETHRQV-PINPYGRTKYIVEQALADYDQYGSLRSVVLRYFNAAGADF 178
Query: 178 --------KRSNHGVIYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTINGILH 223
+ H + L R ++ G DG + Y+HV D + +
Sbjct: 179 EGRIGEWHQPETHAIPLAIDAALGRRQG-FKVFGSDYETRDGTCVRDYIHVLDLADAHVR 237
Query: 224 IFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKF 283
EY + NLG TVKE+ + E ++ G + GD
Sbjct: 238 AVEYLLKGGDSV-ALNLGTGTGTTVKELLGAIEEVSNRPFPVEYIGRRE------GDSHT 290
Query: 284 MLLSIEKAKKT-GWRPKMNSYEAVR 307
++ + +KA+ GW P+ + E +R
Sbjct: 291 LVANNDKARDVLGWVPQYDLSEIIR 315
>dbj|BAB03000.1| (AP001297) nucleotide sugar epimerase-like protein [Arabidopsis
thaliana]
Length = 460
Score = 97.1 bits (238), Expect = 2e-19
Identities = 85/335 (25%), Positives = 145/335 (42%), Gaps = 25/335 (7%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNR----WLENENFEFIRGD 56
+ VLVTG AGF+GSH L + G V D+ + +L R LE + + GD
Sbjct: 112 LSVLVTGAAGFVGSHCSLALRKRGDGVLGFDNFNDYYDPSLKRARQELLEKQQVFIVEGD 171
Query: 57 MRDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK- 113
+ D ++++ D V + HLAA VR + ++P+ +N+ NLL+ + +N +
Sbjct: 172 LNDGPLLRKLFDVVPFTHILHLAAQAGVRYAMKNPQSYIASNIAGFVNLLEVAKAANPQP 231
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+V+ SSS+VYG P E + +P S+Y K A E + Y HI+G R
Sbjct: 232 AIVWASSSSVYGLNTENPFSEEHRTDQPASLYAATKKAGEEIAHTYNHIYGLSLTGLRFF 291
Query: 174 NIIGKRSNHGVIYDFINKLKRNPNELEIL---GDGKQRKSYLHVSDTINGILHIFEYF-- 228
+ G + Y F K + ++I + + + + ++ D + G + +
Sbjct: 292 TVYGPWGRPDMAYFFFTKDILHGKSIDIYRTQDNQEVARDFTYIDDIVKGCVGALDTAEK 351
Query: 229 -------KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDV 281
KR VYNLGN + V + I+ +G K GDV
Sbjct: 352 STGSGGKKRGQAQLRVYNLGNTSPVPVGRLVSILEGLLGTKAKKHLI-----KMPRNGDV 406
Query: 282 KFMLLSIEKA-KKTGWRPKMNSYEAVRRTVRELLG 315
+ ++ A K G++P + +R+ V+ +G
Sbjct: 407 PYTHANVSLAYKDFGYKPTTDLAAGLRKFVKWYVG 441
>sp|Q04973|VIPB_SALTI VI POLYSACCHARIDE BIOSYNTHESIS PROTEIN VIPB/TVIC
>gi|1361288|pir||C36892 Vi polysaccharide biosynthetic
protein vipB - Salmonella typhi
>gi|47961|emb|CAA47992.1| (X67785) wcdB; ORF3 in
citation [1] [Salmonella typhi]
>gi|426446|dbj|BAA03193.1| (D14156) WcdB protein
[Salmonella typhi]
Length = 348
Score = 96.7 bits (237), Expect = 3e-19
Identities = 90/327 (27%), Positives = 146/327 (44%), Gaps = 29/327 (8%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLN---------RWLENENFEFIR 54
L+TG AGFIGS L++ L+ V LD+ S G NL+ +W F FI+
Sbjct: 19 LITGVAGFIGSGLLEELLFLNQTVIGLDNFSTGYQHNLDDVRTSVSEEQW---SRFIFIQ 75
Query: 55 GDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF 114
GD+R + ++A +V+ V H AA V S + P N+ N+L A R+++V
Sbjct: 76 GDIRKFTDCQKACKNVDYVLHQAALGSVPRSLKDPIATNSANIDGFLNMLTAARDAHVSS 135
Query: 115 LVFTSSSTVYGDANVLP-TPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
+ +SS+ YGD LP E G P+S Y K E +A + F A+ R
Sbjct: 136 FTYAASSSTYGDHPDLPKIEERIG--RPLSPYAVTKYVNELYADVFARSYEFNAIGLRYF 193
Query: 174 NIIGKRSNHGVIYD------FINKLKRNPNELEILGDGKQRKSYLHVSDTI--NGILHIF 225
N+ G+R N Y ++ LK P + I GDG + + ++ + I N +
Sbjct: 194 NVFGRRQNPNGAYSAVIPRWILSLLKDEP--IYINGDGSTSRDFCYIENVIQANLLSATT 251
Query: 226 EYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFML 285
+NK VYN+ D ++ E+ ++ + + L + GDVK
Sbjct: 252 NDLASKNK---VYNVAVGDRTSLNELYYLIRDGLNLWRNEQSRAEPIYKDFRDGDVKHSQ 308
Query: 286 LSIEKAKK-TGWRPKMNSYEAVRRTVR 311
I K K + P+ + E +++T++
Sbjct: 309 ADITKIKTFLSYEPEFDIKEGLKQTLK 335
>emb|CAB65206.1| (AJ007311) RmlB protein [Legionella pneumophila]
Length = 351
Score = 96.7 bits (237), Expect = 3e-19
Identities = 88/334 (26%), Positives = 157/334 (46%), Gaps = 38/334 (11%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGY-EVRV--LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
+LVTG AGFIGS+ V + M D Y E+++ LD L+ AG+ NL+ E +N F++GD+
Sbjct: 25 LLVTGAAGFIGSNFV-KFMNDKYPEIKIISLDKLTYAGNKANLSEMAECKNHLFVQGDIL 83
Query: 59 DYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D +V + + E+ + H AA V S +P++ ETNV+ T+ LL+A R
Sbjct: 84 DKSLVLSLLREYEIDTLVHFAAESHVDNSIDNPQIFLETNVIGTFTLLEAARIYWLNERQ 143
Query: 109 --ESNVKFLVFTSSSTVYGD-ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGF 165
+S +F S+ VYG P +P S Y +K +++ ++ Y H +G
Sbjct: 144 WDKSKCRF-HHVSTDEVYGSLEREEPAFTEKNSYQPNSPYSASKASSDHIVRAYYHTYGL 202
Query: 166 RALIFRLANIIGKRSNH-----GVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTING 220
+N G + V+Y +N+L + + G+G + +L+V D
Sbjct: 203 PVTTSNCSNNYGPNQHKEKLIPKVVYACVNQL-----PITVYGNGSNIRDWLYVMDHCEA 257
Query: 221 ILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGD 280
I I + + + +VYN+G + + + +++ + M K V+ +G D
Sbjct: 258 IDTIIQ----KGALGEVYNIGGNNELDNLSLIKMICQMM---DDLKPMEIVEDRKG--HD 308
Query: 281 VKFMLLSIEKAKKTGWRPKMNSYEAVRRTVRELL 314
++ + + + K+ GW P+ + + TV L
Sbjct: 309 KRYAIDNSKIQKELGWVPQGDFVHKLSNTVHHYL 342
>pir||S76937 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1653939|dbj|BAA18849.1| (D90917) HrEpiB
[Synechocystis sp.]
Length = 312
Score = 96.3 bits (236), Expect = 4e-19
Identities = 83/314 (26%), Positives = 140/314 (44%), Gaps = 20/314 (6%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDY 60
MK+L+TGG G+IGS L L+ GY+V V+D+ +L + E F IRGD R
Sbjct: 3 MKILITGGGGYIGSVLTPTLLAAGYQVTVIDNFMF-QQNSLAECCQYETFNVIRGDCRKE 61
Query: 61 KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSS 120
++KE + +V+ LAA + S+ TN + Q + T+S
Sbjct: 62 DLIKEQLKTADVIIPLAALVGAPLCSRDQIGTKTTNQTAVEMICQLASPQQRILMPVTNS 121
Query: 121 STVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
G+ T ES PL PIS+YG K+ AE + + ++ FRLA + G
Sbjct: 122 GYGIGEKGKFCTEES--PLRPISLYGVTKVEAEKAV-----LARDNSMTFRLATVFGMAP 174
Query: 181 NHGV---IYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDV 237
V + DF+ + + ++ +G +++Y+H+ D LH E F+
Sbjct: 175 RMRVDLLVNDFV--YRAFYDRAVVIFEGHFKRNYIHIRDVAKVFLHGLENFESMKG--KP 230
Query: 238 YNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWR 297
YN+G ED K E+ +E P F + ++ G D + ++S ++ TG+
Sbjct: 231 YNVGLEDANLSK--LELCAEIRKYLPNFVY---LEAPIGEDPDKRDYIVSNQRILSTGFT 285
Query: 298 PKMNSYEAVRRTVR 311
P + ++ ++
Sbjct: 286 PDWSLGRGIQELIK 299
>sp|O65781|GAE2_CYATE UDP-GLUCOSE 4-EPIMERASE GEPI48 (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437270|pir||T10498 UDPglucose
4-epimerase (EC 5.1.3.2) (clone GEPI48) - guar
>gi|3021357|emb|CAA06339.1| (AJ005082) UDP-galactose
4-epimerase [Cyamopsis tetragonoloba]
Length = 350
Score = 95.2 bits (233), Expect = 9e-19
Identities = 94/332 (28%), Positives = 146/332 (43%), Gaps = 35/332 (10%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENE-----NFEFIRGDM 57
VLVTGGAG+IGSH V +L+ G++ V+D+L S ++R E N F + D+
Sbjct: 6 VLVTGGAGYIGSHTVLQLLLGGFKAVVVDNLDNSSETAIHRVKELAGKFAGNLSFHKLDL 65
Query: 58 RDYKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFL 115
RD +++ + V H A V S Q P L Y+ N++ T L + + K L
Sbjct: 66 RDRDALEKIFSSTKFDSVIHFAGLKAVGESVQKPLLYYDNNLIGTIVLFEVMAAHGCKKL 125
Query: 116 VFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISG-YAHIFGFRALIFRLAN 174
VF+SS+TVYG +P E + PL + YG KL E + Y ++ ++ R N
Sbjct: 126 VFSSSATVYGLPKEVPCTEEF-PLSAANPYGRTKLIIEEICRDIYRAEQEWKIILLRYFN 184
Query: 175 IIGKRSNHGV----------IYDFINKLK--RNPNELEILG------DGKQRKSYLHVSD 216
+G + + + F+ ++ R P L + G DG + Y+HV D
Sbjct: 185 PVGAHPSGYIGEDPRGIPNNLMPFVQQVAVGRRP-ALTVFGNDYTTSDGTGVRDYIHVVD 243
Query: 217 TINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRG 276
+G + +VYNLG +V E+ + + G K V GR
Sbjct: 244 LADGHIAALRKLNDPKIGCEVYNLGTGKGTSVLEMVKAFEQASG-----KKIPLVMAGRR 298
Query: 277 WKGDVKFMLLSIEKA-KKTGWRPKMNSYEAVR 307
GD + + S KA ++ W+ K E R
Sbjct: 299 -PGDAEVVYASTNKAERELNWKAKYGIDEMCR 329
>pir||E69148 UDP-glucose 4-epimerase related protein - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621436|gb|AAB84881.1| (AE000823) UDP-glucose
4-epimerase related protein [Methanobacterium
thermoautotrophicum]
Length = 332
Score = 94.8 bits (232), Expect = 1e-18
Identities = 92/317 (29%), Positives = 153/317 (48%), Gaps = 21/317 (6%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
VLVTGGAG +GS+L L + G V +LD+LS+ N+ E EN EF++GD+ D ++
Sbjct: 14 VLVTGGAGCVGSNLTGNLAKAGANVIILDNLSSSYEWNIP---EYENIEFVKGDILDDEV 70
Query: 63 VKEAVDD-VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
+K + + VFHLAA+ + S +PE N L +L+ + V+ V++SS
Sbjct: 71 LKRVFKERPDYVFHLAAHFANQNSVDNPEKDLLVNGLGILKVLEYAQLVGVERFVYSSSG 130
Query: 122 T-VYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRS 180
VYG + +P E + + Y KL E + + +++ + R N+ G
Sbjct: 131 CGVYGLDSKIPFEEHDISISLHTPYQVTKLLGELYTNYFHNLYEMPIVNARFFNVFGPGE 190
Query: 181 NHGVIYDFINKL---KRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDV 237
G + I N L I GDG + + + V D + G++ + R+ I +
Sbjct: 191 VPGKYRNVIPNFFYWAMNQQPLPITGDGSETRDWTFVEDIVRGLMAM---GVRREAIGEA 247
Query: 238 YNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGV--DGGRGWKGDVKFMLLSIEKAKK-T 294
NLG+ V E+A I++ E+ +P GV R W + +L SI+KA++
Sbjct: 248 INLGSGTEHQVIEMAGIIN-ELTENP-----AGVVYRPRRDWDAKTR-LLSSIDKARRLL 300
Query: 295 GWRPKMNSYEAVRRTVR 311
+ P+++ E + RT R
Sbjct: 301 DYEPQVSFREGLERTHR 317
>gb|AAG09513.1|AF279619_1 (AF279619) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 94.8 bits (232), Expect = 1e-18
Identities = 90/340 (26%), Positives = 149/340 (43%), Gaps = 39/340 (11%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+LVTGGAGFIGS +V +++D + V +D L+ AG+LE+L E+ + F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIIKDTQDTVVNVDKLTYAGNLESLTEVSESHRYHFEHADIC 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D ++ + V HLAA V S P ETN++ TY LL+A R
Sbjct: 61 DKAAMERIFVTHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARSYWNALDV 120
Query: 109 ESNVKF-LVFTSSSTVYGD---------ANVLPTPESYGPLEPISVYGGAKLAAEALISG 158
E F S+ VYGD +VLP P S Y +K +++ L+
Sbjct: 121 EKKAAFRFHHISTDEVYGDLPHPDEVSAGSVLPLFTEKTAYAPSSPYSASKASSDHLVRA 180
Query: 159 YAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTI 218
+ +GF ++ +N G + + L I G G Q + +L+V D
Sbjct: 181 WLRTYGFPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDHA 240
Query: 219 NGILHIFEYFKRQNKIFDVYNLG------NEDWI-TVKEIA-EIVSEEMGLSPKFKFTGG 270
+ + Q + + YN+G N D + T+ ++ EIV +E + +
Sbjct: 241 RALYTVV----TQGVVGETYNIGGHNEKKNLDVVQTICDLLDEIVPKEGAYRDQLIYVTD 296
Query: 271 VDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G D ++ + + + + + GW+P+ +R+TV
Sbjct: 297 RPG-----HDRRYAIDAAKISDELGWKPQETFESGIRKTV 331
>sp|Q59083|EXOB_AZOBR UDP-GLUCOSE 4-EPIMERASE (UDP-GALACTOSE 4-EPIMERASE)
(GALACTOWALDENASE) >gi|2120532|pir||I39490 UDPglucose
4-epimerase (EC 5.1.3.2) - Azospirillum brasilense
>gi|396521|emb|CAA80967.1| (Z25478) UDP-glucose
4-epimerase [Azospirillum brasilense]
Length = 348
Score = 94.4 bits (231), Expect = 2e-18
Identities = 87/328 (26%), Positives = 141/328 (42%), Gaps = 34/328 (10%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
+VLVTGGAG+IGSH++ L + G +DDLSAG E + + + GD+ +
Sbjct: 10 RVLVTGGAGYIGSHVLHALTDAGIPAVTIDDLSAGRREAIPAAV-----PLVEGDIGSAE 64
Query: 62 IVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTS 119
++ + D V+ V H A + V S P Y N + LL A + + +VF+S
Sbjct: 65 LLDRVMRDHRVDAVMHFAGSIVVPESVVKPLDYYRNNTANSLTLLGACLRAGIDKVVFSS 124
Query: 120 SSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKR 179
++ VYG +P E P PI+ YG +KL E ++ G R++I R N+ G
Sbjct: 125 TAAVYGAPESVPIRED-APTVPINPYGASKLMTEQMLRDAGAAHGLRSVILRYFNVAGAD 183
Query: 180 -----------SNHGVIYDFINKLKRNPNELEILG------DGKQRKSYLHVSDTINGIL 222
+ H + L R P L I G DG + Y+HVSD + +
Sbjct: 184 PAGRTGQATPVATHLIKVACQALLGRRP-PLAIFGTDYDTPDGTCIRDYIHVSDLADAHV 242
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVK 282
+ +R + N G +V+E+ + E G F GD
Sbjct: 243 LALLHLRRGGGSL-LMNCGYGRGASVREVVRTLEEVSGEQVPATFAD------RRPGDPP 295
Query: 283 FMLLSIEKAK-KTGWRPKMNSYEAVRRT 309
++ ++ + + GW PK + + + R+
Sbjct: 296 QLVAGADRIREQLGWVPKHDRLDGIVRS 323
>sp|P55462|RFBB_RHISN PROBABLE DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|2182408|gb|AAB91680.1|
(AE000074) Y4gF [Rhizobium sp. NGR234]
Length = 350
Score = 93.6 bits (229), Expect = 3e-18
Identities = 90/330 (27%), Positives = 149/330 (44%), Gaps = 29/330 (8%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
M++LVTGGAGFIGS LV L+ EV +D L+ AG+L +L N+ F+R D+ D
Sbjct: 1 MRILVTGGAGFIGSALVRYLVSINAEVLNVDKLTYAGNLASLKPVEGLRNYRFLRADICD 60
Query: 60 YKIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRE--SNVK-- 113
+ EA + + V HLAA V S + +TNV T+ +L+ R+ SN+
Sbjct: 61 RVAINEAFETFQPDYVIHLAAESHVDRSITGADDFVQTNVNGTFTMLETARQYWSNLSQN 120
Query: 114 -----FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRAL 168
++ S+ VYG E P +P S Y +K A++ + + +G +
Sbjct: 121 RKAFFKMLHVSTDEVYGSLGDRGQFEEVSPYDPSSPYSASKAASDHFATAWQRTYGLPVV 180
Query: 169 IFRLANIIG--KRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFE 226
I +N G + +N L R P L + G G + +L+V D + I
Sbjct: 181 ISNCSNNYGPFHFPEKLIPLMILNALDRKP--LPVYGTGSNIRDWLYVDDHARALWLIV- 237
Query: 227 YFKRQNKIFDVYNLGNEDWI----TVKEIAEIVSEEMGLSPKFKFTGG-VDGGRGWKG-D 280
R+ + + YN+G + + V I ++ E LSP G + + G D
Sbjct: 238 ---REGRPGEKYNVGGRNELRNIDVVNRICLLLDE---LSPNASHYGDLITFVKDRPGHD 291
Query: 281 VKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
++ + + + + GW+ + N +R+TV
Sbjct: 292 ARYAIDATKLETELGWKAQENFDTGIRKTV 321
>pir||T15370 hypothetical protein C01F1.3 - Caenorhabditis elegans
>gi|1330395|gb|AAB00715.1| (U58761) coded for by C.
elegans cDNA yk62h9.5; coded for by C. elegans cDNA
yk62h9.3; similarity to DTDP-glucose 4,6-Dehydratases
[Caenorhabditis elegans]
Length = 631
Score = 93.2 bits (228), Expect = 4e-18
Identities = 86/340 (25%), Positives = 154/340 (45%), Gaps = 48/340 (14%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRD--- 59
V++TGG GFIGS+ V+ + D + N+++ + N + + + +R+
Sbjct: 8 VVITGGCGFIGSNFVN---------YIHDAWPTCNFVNIDKLILNSDTQNVAESVRNSPR 58
Query: 60 YKIVKEAV------------DDVEVVFHLAAN-PEVRISSQSPELLYETNVLITYNLLQA 106
YK+V + ++++ V H AA+ R +++ E + + NVL L+
Sbjct: 59 YKLVLTDIKNEAAILNVFEQNEIDTVIHFAADCTSTRCYNETAEAV-QNNVLSFIQFLET 117
Query: 107 IRE-SNVKFLVFTSSSTVYGDANVLPTPE---SYGPLEPISVYGGAKLAAEALISGYAHI 162
+R +K V S+ VYGD+++ + + L P + Y K+A EA + Y
Sbjct: 118 VRTYGKIKRFVHISTDEVYGDSDLSENEQGKVEFSRLVPGNPYAATKIAGEAYVRAYQTQ 177
Query: 163 FGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGIL 222
+ + R+ NI G + ++ + E I G GKQ +S+L V D G+
Sbjct: 178 YNLPIVTARMNNIYGPNQWDVKVVPRFIEIAKVRGEYTIQGSGKQLRSWLFVDDASAGLK 237
Query: 223 HIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLS-------PKFKFTGGVDGGR 275
+ E + ++ ++YNLG V ++A+ + EE+ L PK+K
Sbjct: 238 AVCE----KGELHEIYNLGTYYEKNVADLAKTIQEEVDLQLGRAHEPPKYKSIPDRP--- 290
Query: 276 GWKGDVKFMLLSIEKAKK-TGWRPKMNSYEAVRRTVRELL 314
D+++ L+SIEKAK GW P + + +R TV L
Sbjct: 291 --YNDLRY-LISIEKAKNDLGWEPTTSFDDGMRHTVASAL 327
>gb|AAC70775.1| (AF097519) dTDP-D-glucose 4,6 dehydratase [Klebsiella pneumoniae]
Length = 354
Score = 93.2 bits (228), Expect = 4e-18
Identities = 91/337 (27%), Positives = 152/337 (45%), Gaps = 36/337 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY-EVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+LVTGGAGFIGS +V ++E+ EVRV+D L+ AG+LE+L +E + F + D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIIENTLDEVRVMDCLTYAGNLESLAPVAGSERYSFSQTDIT 60
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------E 109
D V + ++V HLAA V S P TNV+ T+ LL+A R E
Sbjct: 61 DAAAVAAQFSEFRPDIVMHLAAESHVDRSIDGPAAFIHTNVIGTFTLLEAARHYWSGLVE 120
Query: 110 SNVKFLVFTSSST--VYGD-----ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHI 162
+ F ST VYGD + P SY P P Y +K ++ L+ +
Sbjct: 121 EQKQAFRFHHISTDEVYGDLHRSQSTCPPKKTSYAPSSP---YSASKAGSDHLVRAWNRT 177
Query: 163 FGFRALIFRLANIIGKR--SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTING 220
+G ++ +N G + +N L P L + G+G+Q + +L+V +
Sbjct: 178 YGLPLVVTNCSNNYGPYHFPEKLIPLTILNALAGKP--LPVYGNGEQIRDWLYVEEHARA 235
Query: 221 ILHIFEYFKRQNKIFDVYNLG----NEDWITVKEIAEIVSEEMGLSPK--FKFTGGVDGG 274
+ + + K + YN+G ++ V+ I I+ + + P F +
Sbjct: 236 LYKV----ATEGKSGETYNIGGHNERKNIDVVRTICTILDKVVAQKPGNITHFADLITFV 291
Query: 275 RGWKG-DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G D+++ + + + + GW P+ + +TV
Sbjct: 292 TDRPGHDLRYAIDATKIQRDLGWVPQETFESGIEKTV 328
>pir||B83000 dTDP-D-glucose 4,6-dehydratase PA5161 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951463|gb|AAG08546.1|AE004929_1 (AE004929)
dTDP-D-glucose 4,6-dehydratase [Pseudomonas aeruginosa]
Length = 352
Score = 92.8 bits (227), Expect = 5e-18
Identities = 90/332 (27%), Positives = 151/332 (45%), Gaps = 27/332 (8%)
Query: 1 MKVLVTGGAGFIGSHLV-DRLMEDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
M +LVTG AGFIG++ V D L V LD L+ AG+ +NL + F+ GD+
Sbjct: 1 MTILVTGSAGFIGANFVLDWLALHDEPVVSLDKLTYAGNRQNLASLDGDARHTFVAGDIG 60
Query: 59 DYKIVKEAVDDVE--VVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D ++V + + + + + AA V S PE +TN++ T+ LL+ +R
Sbjct: 61 DSQLVARLLAEHQPRAILNFAAESHVDRSIHGPEDFIQTNIVGTFRLLEEVRAYWGALEP 120
Query: 109 ESNVKF-LVFTSSSTVYGD-ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFR 166
E+ F + S+ VYG A P EP S Y +K A++ L+ Y H +G
Sbjct: 121 EAKAAFRFLHVSTDEVYGSLAPSDPAFTENNRYEPNSPYSASKAASDHLVRAYHHTYGLP 180
Query: 167 ALIFRLANIIGKRSNHGVIYDFI--NKLKRNPNELEILGDGKQRKSYLHVSDTINGILHI 224
L +N G + + N L P L I GDG+Q + +L+V D + I +
Sbjct: 181 VLTTNCSNNYGPYHFPEKLIPLVIHNALAGKP--LPIYGDGQQIRDWLYVKDHCSAIRRV 238
Query: 225 FEYFKRQNKIFDVYNLG--NE--DWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG- 279
E ++ + YN+G NE + V+ + I+ +E + + + + G
Sbjct: 239 LE----AGQLGETYNVGGWNEKANLDVVETLCAILDQEQPRADGRSYREQITFVKDRPGH 294
Query: 280 DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
D ++ + + ++ GW+P +R+TVR
Sbjct: 295 DRRYAIDATRLERELGWKPAETFETGIRKTVR 326
>emb|CAB01951.1| (Z79692) ExpA9 [Sinorhizobium meliloti]
Length = 356
Score = 92.1 bits (225), Expect = 8e-18
Identities = 89/340 (26%), Positives = 149/340 (43%), Gaps = 45/340 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE-VRVLDDLS-AGSLENLNRWLENENFEFIRGDMR 58
M+VLVTGGAGFIGS + L+ +G E V +D L+ AGSL +L + ++ F R D+R
Sbjct: 1 MRVLVTGGAGFIGSAVCRHLIRNGAERVVNVDKLTYAGSLASLRAVESDPHYAFYRADIR 60
Query: 59 DYKIVKEAV--DDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAI--------R 108
D +++ + + + ++ + HLAA V S +SP+ ETNVL T LL A
Sbjct: 61 DEQVLLQIMRRERIDAIMHLAAESHVDRSIESPDPFMETNVLGTVRLLNAALAYWSGLGT 120
Query: 109 ESNVKF-LVFTSSSTVYGD----ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF 163
E +F S+ V+GD + Y P P Y +K AA+ + H +
Sbjct: 121 EERGRFRFHHVSTDEVFGDLPFNRGIFSEETRYAPSSP---YAASKAAADHFARAWYHTY 177
Query: 164 GFRALIFRLANIIG--KRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGI 221
G ++ +N G + IN ++ P L + G G + +LHV+D +
Sbjct: 178 GLPVVVSNCSNNYGPFHFPEKLIPLTIINAIEEKP--LPLYGSGANVRDWLHVADHATAL 235
Query: 222 LHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-- 279
E + + + YN+G + E + + + + K GG ++
Sbjct: 236 ----ELVVSRGRPGESYNIGARAERNNLSVMECICDLLDVRLPRK------GGDSYRDLI 285
Query: 280 ---------DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
D ++ + + ++ GWRPK + + TV
Sbjct: 286 TLVPDRPGHDRRYAIDPSKAERELGWRPKRSFEGGLSETV 325
>dbj|BAA19633.1| (AB002668) dTDP-D-glucose-4,6-dehydratase [Actinobacillus
actinomycetemcomitans]
Length = 355
Score = 92.1 bits (225), Expect = 8e-18
Identities = 88/331 (26%), Positives = 152/331 (45%), Gaps = 29/331 (8%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRDY 60
+LVTGGAGFIGS +V ++E+ + V +D L+ AG+LE+L N + F + D+ D
Sbjct: 5 ILVTGGAGFIGSAVVRYIIENTQDSVVNVDKLTYAGNLESLEAVKNNPRYIFEQVDICDA 64
Query: 61 KIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR--------ES 110
K + + + V HLAA V S P ETN++ TY LL+A R E
Sbjct: 65 KALARIFEQHQPDAVMHLAAESHVDRSIDGPATFIETNIVGTYILLEAARAYWSSLIDEK 124
Query: 111 NVKF-LVFTSSSTVYGD---ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFR 166
F S+ VYGD N L T + P P S Y +K +++ L+ + +
Sbjct: 125 KAGFRFHHISTDEVYGDLDGTNNLFTETT--PYSPSSPYSASKASSDHLVRAWLRTYSLP 182
Query: 167 ALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFE 226
++ +N G + + I + L + G+G+Q + +L V D + +
Sbjct: 183 TIVTNCSNNYGPKVFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVV- 241
Query: 227 YFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFTGGVDGGRGWKG- 279
+ KI + YN+G + V+ I ++ E + P K+ + + G
Sbjct: 242 ---TEGKIGETYNIGGHNEKANIDVVRTICALLEELVPDKPAGVTKYEDLITYVKDRPGH 298
Query: 280 DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
DV++ + + + +++ GW+P+ +R+TV
Sbjct: 299 DVRYAIDATKISRELGWKPQETFESGIRKTV 329
>gb|AAF33465.1| (AF233324) 89% identity with E. coli dTDP-D-glucose-4,6-dehydratase
(RFFG) (SP:P27830); contains similarity to Pfam family
PF01370 (NAD dependent epimerase/dehydratase family),
score=721.7, E=3.2e-213, N=1 [Salmonella typhimurium
LT2]
Length = 355
Score = 92.1 bits (225), Expect = 8e-18
Identities = 88/338 (26%), Positives = 155/338 (45%), Gaps = 39/338 (11%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYE-VRVLDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
++LVTGGAGFIGS +V ++ + + V V+D L+ AG+L +L +++ F F + D+ D
Sbjct: 3 RILVTGGAGFIGSAVVRHIIHETADAVVVVDKLTYAGNLMSLASVAQSDRFAFEKVDICD 62
Query: 60 YKIVKEAVDDVEV--VFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR--------E 109
++ + V HLAA V S P ETN++ TY LL+A R +
Sbjct: 63 RASLERVFQQYQPDSVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWSALDAD 122
Query: 110 SNVKF-LVFTSSSTVYGDANVLPTPESY----GPLEPISVYGGAKLAAEALISGYAHIFG 164
+ F S+ VYGD L T + + P P S Y +K +++ L+ + +G
Sbjct: 123 AKAAFRFHHISTDEVYGD---LHTADDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYG 179
Query: 165 FRALIFRLANIIGKR--SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGIL 222
L+ +N G + +N L P L + G+G+Q + +L+V D +
Sbjct: 180 LPTLVTNCSNNYGPYHFPEKLIPLMILNALAGKP--LPVYGNGQQIRDWLYVEDHARALY 237
Query: 223 HIFEYFKRQNKIFDVYNLG----NEDWITVKEIAEIVSE-----EMGLSPKFKFTGGVDG 273
H+ + + YN+G ++ V+ I ++ E G+ VD
Sbjct: 238 HVV----TNGAVGETYNIGGHNERKNLDVVRTICALLEELAPQKPQGVVNYHDLITFVDD 293
Query: 274 GRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
G D+++ + + + A++ GW P+ +R+TV+
Sbjct: 294 RPG--HDLRYAIDASKIARELGWTPQETFESGMRKTVQ 329
>pir||S74751 CDP-glucose 4,6-dehydratase - Synechocystis sp. (strain PCC 6803)
>gi|1651976|dbj|BAA16902.1| (D90901) CDP-glucose
4,6-dehydratase [Synechocystis sp.]
Length = 360
Score = 91.7 bits (224), Expect = 1e-17
Identities = 96/328 (29%), Positives = 151/328 (45%), Gaps = 34/328 (10%)
Query: 3 VLVTGGAGFIGSHLVDRLME-----DGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDM 57
V +TG GF GS L L + GY + L + + L + + L ++ R D+
Sbjct: 12 VFLTGHTGFKGSWLTLWLSQLGAKVSGYSLDPLTNPNLCELAEIAKCLRSDT----RADV 67
Query: 58 RDYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRES-NVKF 114
D +++A+ + E+VFHLAA P VR S + P + TNV+ T +LL+A+R S +V+
Sbjct: 68 NDLANLQKAIAEARPEIVFHLAAQPLVRRSYRDPVGTFATNVMGTAHLLEALRASDSVRV 127
Query: 115 LVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF----GFRALIF 170
+V ++ VY + L Y +K A E +++ Y F G
Sbjct: 128 VVIVTTDKVYRNVEWCWPYREDDQLGGHDPYSASKAACEIVVASYRDAFLREQGVAVASA 187
Query: 171 RLANII--GKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYF 228
R N+I G S +I D + L + + I+ + + + HV + + G L + +
Sbjct: 188 RAGNVIGGGDWSEDRLIPDVVRAL--DAKTMVIIRRPQAIRPWQHVLEPLAGYLLLAQKL 245
Query: 229 KRQNKIFDVYNLGNE--DWITVKEIAEIVSE-EMGLSPKFKFTGGVDGGRGWKGDVKFML 285
++ YNLG E D TV++I E S E GL V+ G G +G +
Sbjct: 246 WHSPELAGAYNLGPETKDAATVRQILEFASRIEPGLQ--------VEYGDGNEGPHEAGW 297
Query: 286 LSIEKAKK---TGWRPKMNSYEAVRRTV 310
LS+E AK G+RP EAVRRT+
Sbjct: 298 LSLEIAKARTLLGYRPSWGVEEAVRRTM 325
>pir||T00102 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Actinobacillus
actinomycetemcomitans >gi|3132254|dbj|BAA28131.1|
(AB010415) dTDP-D-glucose-4,6-dehydratase
[Actinobacillus actinomycetemcomitans]
Length = 355
Score = 91.7 bits (224), Expect = 1e-17
Identities = 87/332 (26%), Positives = 150/332 (44%), Gaps = 31/332 (9%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRDY 60
+LVTGGAGFIGS +V ++E+ + V +D L+ AG+LE+L N + F + D+ D
Sbjct: 5 ILVTGGAGFIGSAVVRYIIENTQDSVVNVDKLTYAGNLESLETVKNNPRYIFEQVDICDA 64
Query: 61 KIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR--------ES 110
K + + +VV HLAA V S P ETN++ TY LL+A R E
Sbjct: 65 KALARIFEQHQPDVVMHLAAESHVDRSIDGPAAFIETNIVGTYILLEAARAYWSSLNDEK 124
Query: 111 NVKF-LVFTSSSTVYGD----ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGF 165
F S+ VYGD N+ Y P P Y +K +++ L+ + +
Sbjct: 125 KAGFRFHHISTDEVYGDLDGTKNLFTETTPYSPSSP---YSASKASSDHLVRAWLRTYSL 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIF 225
++ +N G + I + L + G+G+Q + +L V D + +
Sbjct: 182 PTIVTNCSNNYGPFHFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVV 241
Query: 226 EYFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFTGGVDGGRGWKG 279
+ KI + YN+G + V+ I ++ E + P K+ + + G
Sbjct: 242 ----TEGKIGETYNIGGHNEKANIDVVRTICALLEELVPNKPAGVTKYEDLITYVKDRPG 297
Query: 280 -DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
DV++ + + + +++ GW+P+ +R+TV
Sbjct: 298 HDVRYAIDATKISRELGWKPQETFESGIRKTV 329
>dbj|BAA82532.1| (AB030032) dTDP-D-glucose 4,6-dehydratase [Actinobacillus
actinomycetemcomitans]
Length = 355
Score = 91.3 bits (223), Expect = 1e-17
Identities = 87/332 (26%), Positives = 151/332 (45%), Gaps = 31/332 (9%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRDY 60
+LVTGGAGFIGS +V ++E+ + V +D L+ AG+LE+L N + F + D+ D
Sbjct: 5 ILVTGGAGFIGSAVVRYIIENTQDSVVNVDKLTYAGNLESLEAVKNNPRYTFEQVDICDA 64
Query: 61 KIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRE-----SNVK 113
K + + V HLAA V S P ETN++ TY LL+A R ++ K
Sbjct: 65 KALARIFQQHRPDAVMHLAAESHVDRSIDGPAAFIETNIVGTYILLEAARAYWNSLNDEK 124
Query: 114 FLVF----TSSSTVYGDA----NVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGF 165
VF S+ VYGD N+ Y P P Y +K +++ L+ + +
Sbjct: 125 KAVFRFHHISTDEVYGDLDGTNNLFIETTPYSPSSP---YSASKASSDHLVRAWLRTYSL 181
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIF 225
++ +N G + I + L + G+G+Q + +L V D + +
Sbjct: 182 PTIVTNCSNNYGPFHFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVV 241
Query: 226 EYFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFTGGVDGGRGWKG 279
+ KI + YN+G + V+ I ++ E + P K+ + + G
Sbjct: 242 ----AEGKIGETYNIGGHNEKANIDVVRTICALLEELVPNKPAGVTKYEDLITYVKDRPG 297
Query: 280 -DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
DV++ + + + +++ GW+P+ +R+TV
Sbjct: 298 HDVRYAIDATKISRELGWKPQETFESGIRKTV 329
>gb|AAF73454.1|AF264025_5 (AF264025) putative dTDP-glucose 4, 6-dehydratase; AknR
[Streptomyces galilaeus]
Length = 323
Score = 90.9 bits (222), Expect = 2e-17
Identities = 92/324 (28%), Positives = 138/324 (42%), Gaps = 32/324 (9%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGY------EVRVLDDLS-AGSLENLNRWLENENFEFI 53
M+VL+TGGAGFIGSH V L+ V V+D L+ AG NL L + +F
Sbjct: 1 MRVLITGGAGFIGSHYVRSLLAGTLPGPRPSRVTVVDLLTYAGDTGNLP--LADPRLDFR 58
Query: 54 RGDMRDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVK 113
R D+RD + V + V H AA V S P TNVL T +LL+A V
Sbjct: 59 RLDIRDLDALLTVVPGHDAVVHFAAETHVDRSLSEPAEFVRTNVLGTQSLLEASLRGGVG 118
Query: 114 FLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLA 173
V S+ VYG T PL P S Y +K ++ + Y G R A
Sbjct: 119 TFVHVSTDEVYGSI-AQGTWTEEAPLLPNSPYAASKAGSDLVARSYWRTHGLDVRTTRCA 177
Query: 174 NIIGKRSN-HGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQN 232
N G R + +I F+ +L + + GDG + +LHV D + +
Sbjct: 178 NNYGPRQHPEKLIPLFVTELLAG-RPVPLYGDGGNVREWLHVDDHCRAVHAVL----TGG 232
Query: 233 KIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGR-----GWKG-DVKFMLL 286
+ ++YN+G +T +E ++ K G D R KG D+++ +
Sbjct: 233 RPGEIYNIGGGTHLTNRE----------MTAKLLALCGTDWSRVRQVPDRKGHDLRYAVD 282
Query: 287 SIEKAKKTGWRPKMNSYEAVRRTV 310
+ ++ G+RP + + +R V
Sbjct: 283 DTKIREELGYRPLRSLDDGLREVV 306
>gb|AAG09522.1|AF279621_1 (AF279621) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 90.9 bits (222), Expect = 2e-17
Identities = 88/343 (25%), Positives = 149/343 (42%), Gaps = 45/343 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+L+TGGAGFIGS +V ++++ + V +D L+ AG+LE+L+ E+ + F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + + + V HLAA V S P ETN++ TY LL+ R
Sbjct: 61 DSAEIARIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYILLEVARKYWSALGE 120
Query: 109 -ESNVKFLVFTSSSTVYGDANVLPTPESYG-----PL-------EPISVYGGAKLAAEAL 155
+ N S+ VYGD LP P+ PL P S Y +K +++ L
Sbjct: 121 DKKNSFRFHHISTDEVYGD---LPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHL 177
Query: 156 ISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVS 215
+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 178 VRAWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVE 237
Query: 216 DTINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIA--------EIVSEEMGLSPKFKF 267
D LH+ Q ++ + YN+G + E+ EIV +E + +
Sbjct: 238 DHARA-LHM---VVTQGEVGETYNIGGHNEKKNLEVVHTICDLLDEIVPKEGSYRDQITY 293
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G G D ++ + + + +++ GW+P +R+TV
Sbjct: 294 VGDRPG-----HDRRYAIDADKISRELGWKPLETFESGIRKTV 331
>sp|P37777|RFBB_SHIFL DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1073703|pir||B55213 rfbB protein -
Shigella flexneri (strain 2a) >gi|294896|gb|AAA53679.1|
(L14842) dTDP-D-glucose 4,6-dehydratase [Shigella
flexneri]
Length = 361
Score = 90.5 bits (221), Expect = 2e-17
Identities = 89/343 (25%), Positives = 150/343 (42%), Gaps = 45/343 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+LVTGGAGFIGS +V ++ + + V +D L+ AG+LE+L ++E + F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLADVSDSERYAFEHADIC 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------E 109
D + A + V HLAA V S P ETN++ TY LL+A R +
Sbjct: 61 DAVAMSRIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALND 120
Query: 110 SNVKFLVFTSSST--VYGDANVLPTPESYGPLE------------PISVYGGAKLAAEAL 155
K F ST VYGD LP P+ E P S Y +K +++ L
Sbjct: 121 EKKKSFRFHHISTDEVYGD---LPHPDEANNNEALPLFTETTAYAPSSPYSASKASSDHL 177
Query: 156 ISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVS 215
+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 178 VRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVE 237
Query: 216 DTINGILHIFEYFKRQNKIFDVYNLGNED-------WITVKEIA-EIVSEEMGLSPKFKF 267
D + + + K + YN+G + +T+ ++ EIV +E + +
Sbjct: 238 DHARALYTVV----TEGKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITY 293
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G D ++ + + + +++ GW+P+ +R+TV
Sbjct: 294 VADRPG-----HDRRYAIDADKISRELGWKPQETFESGIRKTV 331
>gb|AAG09534.1|AF279624_1 (AF279624) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 90.5 bits (221), Expect = 2e-17
Identities = 85/343 (24%), Positives = 147/343 (42%), Gaps = 45/343 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+L+TGGAGFIGS +V ++++ + V +D L+ AG+LE+L+ E+ + F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + + + V HLAA V S P ETN++ TY LL+ R
Sbjct: 61 DSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGE 120
Query: 109 -ESNVKFLVFTSSSTVYGDANVLPTPESYG-----PL-------EPISVYGGAKLAAEAL 155
+ N S+ VYGD LP P+ G PL P S Y +K +++ L
Sbjct: 121 DKKNSFRFHHISTDEVYGD---LPHPDEVGNSVTLPLFTETTAYAPSSPYSASKASSDHL 177
Query: 156 ISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVS 215
+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 178 VRAWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVE 237
Query: 216 DTINGILHIFEYFKRQNKIFDVYNLGNED--------WITVKEIAEIVSEEMGLSPKFKF 267
D + + + K + YN+G + + + EIV + + +
Sbjct: 238 DHARALYIVV----TEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKANSYREQITY 293
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G D ++ + + + +++ GW+P N +R+TV
Sbjct: 294 VADRPG-----HDRRYAIDADKISRELGWKPLENFESGIRKTV 331
>dbj|BAA94402.1| (AB041266) dTDP-D-glucose 4,6-dehydratase [Actinobacillus
actinomycetemcomitans]
Length = 355
Score = 90.1 bits (220), Expect = 3e-17
Identities = 87/331 (26%), Positives = 151/331 (45%), Gaps = 29/331 (8%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRDY 60
+L+TGGAGFIGS +V ++E+ + V +D L+ AG+LE+L N + F + D+ D
Sbjct: 5 ILITGGAGFIGSAVVRYIIENTQDSVVNVDKLTYAGNLESLEAVKNNPRYIFEQVDICDA 64
Query: 61 KIVKEAVDD--VEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR--------ES 110
K + + + V HLAA V S P ETN++ TY LL+A R E
Sbjct: 65 KALARIFEQHQPDAVMHLAAESHVDRSIDGPATFIETNIVGTYILLEAARAYWSSLNDEK 124
Query: 111 NVKF-LVFTSSSTVYGD---ANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFR 166
F S+ VYGD N L T + P P S Y +K +++ L+ + +
Sbjct: 125 KAGFRFHHISTDEVYGDLDGTNNLFTETT--PYSPSSPYSASKASSDHLVRAWLRTYSLP 182
Query: 167 ALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFE 226
++ +N G + I + L + G+G+Q + +L V D + +
Sbjct: 183 TIVTNCSNNYGPFHFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVV- 241
Query: 227 YFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFTGGVDGGRGWKG- 279
+ KI + YN+G + V+ I ++ E + P K+ + + G
Sbjct: 242 ---TEGKIGETYNIGGHNEKANIDVVRTICALLEELVPDKPAGVTKYEDLITYVKDRPGH 298
Query: 280 DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
DV++ + + + +++ GW+P+ +R+TV
Sbjct: 299 DVRYAIDATKISRELGWKPQETFESGIRKTV 329
>sp|P55293|RBB2_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437235|pir||S78542 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Escherichia coli (strain
VW187) >gi|799232|gb|AAC63612.1| (AF125322) RmlB
[Escherichia coli]
Length = 361
Score = 89.7 bits (219), Expect = 4e-17
Identities = 86/344 (25%), Positives = 149/344 (43%), Gaps = 47/344 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+LVTGGAGFIGS +V ++ + + V +D L+ AG+LE+L ++E + F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLAEISDSERYSFENADIC 60
Query: 59 DYK--IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + + ++ V HLAA V S P ETN++ TY LL+A R
Sbjct: 61 DAEGDGLYFGQHQLDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSGLDD 120
Query: 109 --ESNVKFLVFTSSSTVYGDANVLPTPESYGPLE------------PISVYGGAKLAAEA 154
+ N +F S+ VYGD LP P+ E P S Y +K +++
Sbjct: 121 EKKKNFRF-HHISTDEVYGD---LPHPDEVNSNETLQLFTETTAYAPSSPYSASKASSDH 176
Query: 155 LISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHV 214
L+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 177 LVRAWKRTYGLPTIVSNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYV 236
Query: 215 SDTINGILHIFEYFKRQNKIFDVYNLGNED--------WITVKEIAEIVSEEMGLSPKFK 266
D + + + K + YN+G + + + EIV +E +
Sbjct: 237 EDHARALYTVV----TEGKAGETYNIGGHNEKKNIDVVFTICDLLDEIVPKEKSYREQIT 292
Query: 267 FTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
+ G D ++ + + + +++ GW+P+ +R+TV
Sbjct: 293 YVADRPG-----HDRRYAIDADKISRELGWKPQETFESGIRKTV 331
>sp|P29782|STRE_STRGR DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|68393|pir||DWSMGG dTDPglucose
4,6-dehydratase (EC 4.2.1.46) [validated] - Streptomyces
griseus >gi|581677|emb|CAA44444.1| (X62567) dTDP-glucose
dehydratase [Streptomyces griseus]
Length = 328
Score = 89.3 bits (218), Expect = 5e-17
Identities = 89/314 (28%), Positives = 135/314 (42%), Gaps = 17/314 (5%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDG----YEVRVLDDLS-AGSLENLNRWLENENFEFIRGDM 57
+LVTG AGFIGS V L+ G V LD L+ AG+ +NL + + F RGD+
Sbjct: 5 LLVTGAAGFIGSQYVRTLLGPGGPPDVVVTALDALTYAGNPDNLAAVRGHPRYRFERGDI 64
Query: 58 RDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
D + +VV HLAA V S + TNV T LL A V V
Sbjct: 65 CDAPGRRVMAGQDQVV-HLAAESHVDRSLLDASVFVRTNVHGTQTLLDAATRHGVASFVQ 123
Query: 118 TSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
S+ VYG E PL P S Y +K + + L + G + R +N G
Sbjct: 124 VSTDEVYGSLEHGSWTED-EPLRPNSPYSASKASGDLLALAHHVSHGLDVRVTRCSNNYG 182
Query: 178 KRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDV 237
R + L + + + + GDG + +LHV D + GI E + + + V
Sbjct: 183 PRQFPEKLIPRFITLLMDGHRVPLYGDGLNVREWLHVDDHVRGI----EAVRTRGRAGRV 238
Query: 238 YNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKG-DVKFMLLSIEKAKKTGW 296
YN+G ++ KE+ ++ E G G V+ KG D ++ + S ++ G+
Sbjct: 239 YNIGGGATLSNKELVGLLLEAAGAD-----WGSVEYVEDRKGHDRRYAVDSTRIQRELGF 293
Query: 297 RPKMNSYEAVRRTV 310
P ++ + + TV
Sbjct: 294 APAVDLADGLAATV 307
>emb|CAB92213.1| (AL356592) NAD-dependent dehydratase. [Streptomyces coelicolor
A3(2)]
Length = 346
Score = 88.2 bits (215), Expect = 1e-16
Identities = 82/311 (26%), Positives = 122/311 (38%), Gaps = 14/311 (4%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
+VLVTGGAGF+GSHL RL++ G EV LD+LS G E + F F+ D+
Sbjct: 19 RVLVTGGAGFLGSHLCTRLLDAGAEVDCLDNLSTGRAEKVAHLAGRPGFRFLERDISAPG 78
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
++V HLA P + L T L +FL+ +SS
Sbjct: 79 CADALTGPYDLVLHLAGPASPAARPDRPVEALDAGSLGTRTALSVAGRDGARFLL--ASS 136
Query: 122 TVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII--GKR 179
G P+ P+ P A AEAL++ +A G A I RL + G R
Sbjct: 137 PPAGPGTRGDAPDDADPVGPHRACAEAVRFAEALVAAHAGANGSNAGIVRLFDGYGPGMR 196
Query: 180 SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYN 239
++ + + + + GDG +V D ++G+L + + +
Sbjct: 197 TDGAGTPAALIEAALTGRPVTVPGDGSGTYPLCYVDDMVDGVLLV-----AAGRSVRPVD 251
Query: 240 LGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPK 299
+G ++ T EIA +V E G F GR V I GW P
Sbjct: 252 IGGDEEPTAAEIARLVIELTGSDSPLAFVEDAGDGRPRPRPVTGFAREI-----FGWLPS 306
Query: 300 MNSYEAVRRTV 310
+ + + RTV
Sbjct: 307 VAWQDGLERTV 317
>gb|AAG09506.1|AF279617_1 (AF279617) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 88.2 bits (215), Expect = 1e-16
Identities = 84/343 (24%), Positives = 146/343 (42%), Gaps = 45/343 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+L+TGGAGFIGS +V ++++ + V +D L+ AG+LE+L+ E+ + F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + + + V HLAA V S P ETN++ TY LL+ R
Sbjct: 61 DSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGE 120
Query: 109 -ESNVKFLVFTSSSTVYGDANVLPTPESYG-----PL-------EPISVYGGAKLAAEAL 155
+ N S+ VYGD LP P+ G PL P S Y +K +++ L
Sbjct: 121 DKKNSFRFHHISTDEVYGD---LPHPDEAGNSVTLPLFTETTAYAPSSPYSASKASSDHL 177
Query: 156 ISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVS 215
+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 178 VRAWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVE 237
Query: 216 DTINGILHIFEYFKRQNKIFDVYNLGNED--------WITVKEIAEIVSEEMGLSPKFKF 267
D + + + K + YN+G + + + EIV + + +
Sbjct: 238 DHARALYIVV----TEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKAASYREQITY 293
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G D ++ + + + +++ GW+P +R+TV
Sbjct: 294 VADRPG-----HDRRYAIDADKISRELGWKPLETFESGIRKTV 331
>gb|AAG09530.1|AF279623_1 (AF279623) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 88.2 bits (215), Expect = 1e-16
Identities = 84/343 (24%), Positives = 145/343 (41%), Gaps = 45/343 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+L+TGGAGFIGS +V ++++ V +D L+ AG+LE+L+ E+ + F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQNTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + + + V HLAA V S P ETN++ TY LL+ R
Sbjct: 61 DSAAITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGE 120
Query: 109 -ESNVKFLVFTSSSTVYGDANVLPTPESYG-----PL-------EPISVYGGAKLAAEAL 155
+ N S+ VYGD LP P+ G PL P S Y +K +++ L
Sbjct: 121 DKKNSFRFHHISTDEVYGD---LPHPDEAGNSVTLPLFTETTAYAPSSPYSASKASSDHL 177
Query: 156 ISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVS 215
+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 178 VRAWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVE 237
Query: 216 DTINGILHIFEYFKRQNKIFDVYNLGNED--------WITVKEIAEIVSEEMGLSPKFKF 267
D + + + K + YN+G + + + EIV + + +
Sbjct: 238 DHARALYIVV----TEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITY 293
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G D ++ + + + +++ GW+P +R+TV
Sbjct: 294 VADRPG-----HDRRYAIDADKISRELGWKPLETFESGIRKTV 331
>sp|P37759|RBB1_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437240|pir||H64969 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Escherichia coli (strain
K-12) >gi|1736731|dbj|BAA15883.1| (D90841) dTDP-glucose
4,6-dehydratase (EC 4.2.1.46). [Escherichia coli]
>gi|1736744|dbj|BAA15895.1| (D90842) dTDP-glucose
4,6-dehydratase (EC 4.2.1.46). [Escherichia coli]
>gi|1788353|gb|AAC75102.1| (AE000294) dTDP-glucose 4,6
dehydratase [Escherichia coli K12]
>gi|2665489|gb|AAB88398.1| (U09876) dTDP-D-glucose
4,6-dehydratase [Escherichia coli]
Length = 361
Score = 87.4 bits (213), Expect = 2e-16
Identities = 86/343 (25%), Positives = 146/343 (42%), Gaps = 45/343 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+LVTGGAGFIGS +V ++ + + V +D L+ AG+ E+L ++E + F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNRESLADVSDSERYVFEHADIC 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + A + V HLAA V S P ETN++ TY LL+A R
Sbjct: 61 DAPAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALDS 120
Query: 109 -ESNVKFLVFTSSSTVYGDANVLPTPESYGPLE------------PISVYGGAKLAAEAL 155
+ N S+ VYGD LP P+ E P S Y +K +++ L
Sbjct: 121 DKKNSFRFHHISTDEVYGD---LPHPDEVNNTEELPLFTETTAYAPSSPYSASKASSDHL 177
Query: 156 ISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVS 215
+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 178 VRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVE 237
Query: 216 DTINGILHIFEYFKRQNKIFDVYNLGNED-------WITVKEIA-EIVSEEMGLSPKFKF 267
D + + + K + YN+G + +T+ ++ EIV +E + +
Sbjct: 238 DHARALYTVV----TEGKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITY 293
Query: 268 TGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
G D ++ + + + + GW+P+ +R+TV
Sbjct: 294 VADRPG-----HDRRYAIDAEKIGRALGWKPQETFESGIRKTV 331
>sp|P26391|RFBB_SALTY DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|96840|pir||S15299 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Salmonella typhimurium
>gi|581654|emb|CAA40115.1| (X56793) dTDP-glucose
4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 87.0 bits (212), Expect = 3e-16
Identities = 89/346 (25%), Positives = 153/346 (43%), Gaps = 51/346 (14%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+L+TGGAGFIGS +V ++++ + V +D L+ AG+LE+L+ E+ + F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + + + V HLAA V S P ETN++ TY LL+ R
Sbjct: 61 DSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSALGE 120
Query: 109 --ESNVKFLVFTSSSTVYGDANVLPTPESYG-----PL-------EPISVYGGAKLAAEA 154
++N +F S+ VYGD LP P+ PL P S Y +K +++
Sbjct: 121 DKKNNFRF-HHISTDEVYGD---LPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDH 176
Query: 155 LISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFI--NKLKRNPNELEILGDGKQRKSYL 212
L+ + +G ++ +N G + + N L+ P L I G G Q + +L
Sbjct: 177 LVRAWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKP--LPIYGKGDQIRDWL 234
Query: 213 HVSDTINGILHIFEYFKRQNKIFDVYNLGNED--------WITVKEIAEIVSEEMGLSPK 264
+V D LH+ + K + YN+G + + + EIV + +
Sbjct: 235 YVEDHARA-LHM---VVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQ 290
Query: 265 FKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
+ G D ++ + + + +++ GW+P +R+TV
Sbjct: 291 ITYVADRPG-----HDRRYAIDAGKISRELGWKPLETFESGIRKTV 331
>pir||I55054 dTDP-D-glucose 4,6-dehydratase - Escherichia coli
Length = 361
Score = 87.0 bits (212), Expect = 3e-16
Identities = 87/344 (25%), Positives = 149/344 (43%), Gaps = 47/344 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+LVTGGAGFIGS +V ++ + + V +D L+ AG+ E+L ++E + F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNRESLADVSDSERYVFEHADIC 60
Query: 59 DYKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + A + V HLAA V S P ETN++ TY LL+A R
Sbjct: 61 DAPAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALDS 120
Query: 109 --ESNVKFLVFTSSSTVYGDANVLPTPESYGPLE------------PISVYGGAKLAAEA 154
E++ +F S+ VYGD LP P+ E P S Y +K +++
Sbjct: 121 DKENSFRF-HHISTDEVYGD---LPHPDEVNNTEELPLFTETTAYAPSSPYSASKASSDH 176
Query: 155 LISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHV 214
L+ + +G ++ +N G + + L I G G Q + +L+V
Sbjct: 177 LVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYV 236
Query: 215 SDTINGILHIFEYFKRQNKIFDVYNLGNED-------WITVKEIA-EIVSEEMGLSPKFK 266
D + + + K + YN+G + +T+ ++ EIV +E +
Sbjct: 237 EDHARALYTVV----TEVKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQIT 292
Query: 267 FTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
+ G D ++ + + + + GW+P+ +R+TV
Sbjct: 293 YVADRPG-----HDRRYAIDAEKIGRALGWKPQETFESGIRKTV 331
>emb|CAB76986.1| (AL159178) putative epimerase [Streptomyces coelicolor A3(2)]
Length = 334
Score = 86.6 bits (211), Expect = 3e-16
Identities = 93/355 (26%), Positives = 133/355 (37%), Gaps = 69/355 (19%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYE---VRVLDDLSAGSLENLNRWLENENFEFIRGDM 57
M+VLVTG AGFIGSH+V+ L E G+E V +D A D+
Sbjct: 1 MRVLVTGSAGFIGSHVVEALREHGHEPVGYDVREDPGA--------------------DV 40
Query: 58 RDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVF 117
RD + A+ V+ V H AA + N L T LL A + V+ LV
Sbjct: 41 RDPAALARALAGVDAVCHQAAMVGLGNGFADAAEYVSRNDLGTAVLLAATAGAGVRRLVL 100
Query: 118 TSSSTVYGDAN--------VLPTPESY---------------------------GPLEPI 142
S VYG+ V P P + P +P
Sbjct: 101 AGSMVVYGEGRYTCARHGVVRPGPRAVADLDAGRFEPTCPRCGADLAPGLVGEDAPADPR 160
Query: 143 SVYGGAKLAAEALISGYAHIFGFRALIFRLANIIGKRSNHGVIY----DFINKLKRNPNE 198
+VY KLA E L + +A G A+ R N+ G R Y F
Sbjct: 161 NVYATTKLAQEHLAAAWARTTGATAVSLRYHNVYGPRMPRDTPYAGVASFFRSALARGEA 220
Query: 199 LEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEE 258
+ DG+QR+ ++HV D + E + YN G+ + TV E+A +S
Sbjct: 221 PRVFEDGRQRRDFVHVRDVAAANVAALESARPPEGALSAYNTGSGEPHTVGEMAVALSAA 280
Query: 259 MGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAK-KTGWRPKMNSYEAVRRTVRE 312
G P+ TG GDV+ + + + WRP++ E +R R+
Sbjct: 281 HG-GPEPVVTGEYR-----LGDVRHITADSARLRTDLDWRPRVGFAEGMREFARD 329
>gb|AAG09509.1|AF279618_1 (AF279618) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 86.6 bits (211), Expect = 3e-16
Identities = 89/346 (25%), Positives = 153/346 (43%), Gaps = 51/346 (14%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMR 58
MK+L+TGGAGFIGS +V ++++ + V +D L+ AG+LE+L+ E+ + F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60
Query: 59 DYKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR-------- 108
D + + + V HLAA V S P ETN++ TY LL+ R
Sbjct: 61 DSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGE 120
Query: 109 --ESNVKFLVFTSSSTVYGDANVLPTPESYG-----PL-------EPISVYGGAKLAAEA 154
++N +F S+ VYGD LP P+ PL P S Y +K +++
Sbjct: 121 DKKNNFRF-HHISTDEVYGD---LPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDH 176
Query: 155 LISGYAHIFGFRALIFRLANIIGKRSNHGVIYDFI--NKLKRNPNELEILGDGKQRKSYL 212
L+ + +G ++ +N G + + N L+ P L I G G Q + +L
Sbjct: 177 LVRAWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKP--LPIYGKGDQIRDWL 234
Query: 213 HVSDTINGILHIFEYFKRQNKIFDVYNLGNED--------WITVKEIAEIVSEEMGLSPK 264
+V D LH+ + K + YN+G + + + EIV + +
Sbjct: 235 YVEDHARA-LHM---VVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKTTSYREQ 290
Query: 265 FKFTGGVDGGRGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTV 310
+ G D ++ + + + +++ GW+P +R+TV
Sbjct: 291 ITYVADRPG-----HDRRYAIDAGKISRELGWKPLETFESGIRKTV 331
>sp|P44914|RFFG_HAEIN DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1075419|pir||C64099 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Haemophilus influenzae
(strain Rd KW20) >gi|1573891|gb|AAC22531.1| (U32769)
DTDP-glucose 4,6-dehydratase (rffG) [Haemophilus
influenzae Rd]
Length = 338
Score = 84.3 bits (205), Expect = 2e-15
Identities = 80/337 (23%), Positives = 144/337 (41%), Gaps = 35/337 (10%)
Query: 1 MKVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLSAGSLENLNRWLENE-NFEFIRGDMR 58
M +LVTGG+GFIGS L+ ++ + + +D L+ + ++ R +EN + F + D+
Sbjct: 2 MNILVTGGSGFIGSALIRYIINHTQDFVINIDKLTYAANQSALREVENNPRYVFEKVDIC 61
Query: 59 DYKIVKEAVD--DVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRE-----SN 111
D +++ + + V HLAA V S +TN++ TY LL+ +
Sbjct: 62 DLNVIENIFEKYQPDAVMHLAAESHVDRSISGAADFVQTNIVGTYTLLEVAKNYWHTLDE 121
Query: 112 VKFLVF----TSSSTVYGDANVL-PTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFR 166
K F S+ VYGD ++ P P P S Y +K A+ L+ + +G
Sbjct: 122 AKKTTFRFHHISTDEVYGDLSLSEPAFTEQSPYHPSSPYSASKAASNHLVQAWHRTYGLP 181
Query: 167 ALIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFE 226
+I +N G + + + L I GDG+Q + +L V D + +
Sbjct: 182 VIITNSSNNYGAYQHAEKLIPLMISNAVMGKPLPIYGDGQQIRDWLFVEDHVQASYLVL- 240
Query: 227 YFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--------FKFTGGVDGG 274
+ ++ + YN+G + VK I +++ E P F G
Sbjct: 241 ---TKGRVGENYNIGGNCEKTNLEVVKRICQLLEELAPSKPNHIKYYEDLMTFVKDRPG- 296
Query: 275 RGWKGDVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
DV++ L + + GW+P++ + +R+TV+
Sbjct: 297 ----HDVRYSLDCSKIHAELGWQPQITFEQGLRQTVK 329
>gb|AAC37049.1| (L09189) dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis]
Length = 355
Score = 82.3 bits (200), Expect = 7e-15
Identities = 90/340 (26%), Positives = 153/340 (44%), Gaps = 43/340 (12%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
K+LVTGGAGFIGS +V ++ + + V LD L+ AG+LE+L +N + F + D+ D
Sbjct: 3 KILVTGGAGFIGSAVVRHIIRNTQDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICD 62
Query: 60 YKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRE-----SNV 112
+ A + V HLAA V S S +TN++ T+NLL+A R +
Sbjct: 63 RAELDRVFAQHRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPSE 122
Query: 113 KFLVF----TSSSTVYGDANVLPTPESY---GPLEPISVYGGAKLAAEALISGYAHIFGF 165
++ F S+ VYGD + T + + P P S Y +K +++ L+ + +G
Sbjct: 123 QYEAFRFHHISTDEVYGDLS--GTDDLFTETAPYAPSSPYSASKASSDHLVRAWLRTYG- 179
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKL-------KRNPNELEILGDGKQRKSYLHVSDTI 218
L I+ SN+ +Y F KL + L + GDG Q + +L V D
Sbjct: 180 ------LPTIVTNCSNNYGLYHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHA 233
Query: 219 NGILHIFEYFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFTGGVD 272
+ + + + + YN+G + VK I ++ E P ++ +
Sbjct: 234 RALYQVV----TEGVVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYEDLIT 289
Query: 273 GGRGWKG-DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
+ G DV++ + + + + GW P +R+TV+
Sbjct: 290 FVQDRPGHDVRYAVDAAKIRRDLGWLPLETFESGLRKTVQ 329
>pir||G82014 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMA0204 [imported] -
Neisseria meningitidis (group B strain MD58, group A
strain Z2491) >gi|4574160|gb|AAD23919.1|AF083467_3
(AF083467) dTDP-D-glucose 4,6-dehydratase [Neisseria
meningitidis] >gi|7378961|emb|CAB83504.1| (AL162752)
dTDP-glucose 4,6-dehydratase [Neisseria meningitidis
Z2491] >gi|7378973|emb|CAB83518.1| (AL162752)
dTDP-glucose 4,6-dehydratase [Neisseria meningitidis
Z2491]
Length = 341
Score = 80.8 bits (196), Expect = 2e-14
Identities = 88/340 (25%), Positives = 150/340 (43%), Gaps = 43/340 (12%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
K+LVTGGAGFIGS +V ++ + + V LD L+ AG+LE+L +N + F + D+ D
Sbjct: 3 KILVTGGAGFIGSAVVRHIIRNTQDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICD 62
Query: 60 YKIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR--------E 109
+ A + V HLAA V S S +TN++ T+NLL+A R E
Sbjct: 63 RAELDRVFAQHRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYRQQMPSE 122
Query: 110 SNVKF-LVFTSSSTVYGDANVLPTPESY---GPLEPISVYGGAKLAAEALISGYAHIFGF 165
+ F S+ VYGD + T + + P P S Y +K +++ L+ + +G
Sbjct: 123 KHEAFRFHHISTDEVYGDLS--GTDDLFTETAPYAPSSPYSASKASSDHLVRAWLRTYGL 180
Query: 166 RALIFRLANIIGKRSNHGVIYDFINKL-------KRNPNELEILGDGKQRKSYLHVSDTI 218
++ +N G Y F KL + L + GDG Q + +L V D
Sbjct: 181 PTIVTNCSNNYGP-------YHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHA 233
Query: 219 NGILHIFEYFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFTGGVD 272
+ + + + + YN+G + VK I ++ E P ++ +
Sbjct: 234 RALYQVV----TEGVVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYEDLIT 289
Query: 273 GGRGWKG-DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
+ G D ++ + + + + GW+P +R+TV+
Sbjct: 290 FVQDRPGHDARYAVDTAKIRRDLGWQPLETFESGLRKTVQ 329
>sp|P26397|RFBG_SALTY CDP-GLUCOSE 4,6-DEHYDRATASE >gi|96842|pir||S15305 rfbG protein -
Salmonella typhimurium >gi|47895|emb|CAA40121.1|
(X56793) CDP-glucose 4,6-dehydratase [Salmonella
enterica]
Length = 359
Score = 80.4 bits (195), Expect = 3e-14
Identities = 85/330 (25%), Positives = 149/330 (44%), Gaps = 29/330 (8%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVR--VLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
+V VTG GF GS L L E G V+ LD + SL + R N+ E GD+RD
Sbjct: 11 RVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLFEIVRL--NDLMESHIGDIRD 68
Query: 60 YKIVKEAVDDV--EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRE-SNVKFLV 116
++ ++ ++ + E+VFH+AA P VR+S + P Y TNV+ T +LL+ +++ N+K +V
Sbjct: 69 FEKLRNSIAEFKPEIVFHMAAQPLVRLSYEQPIETYSTNVMGTVHLLETVKQVGNIKAVV 128
Query: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIF---------GFRA 167
+S Y + + P+ Y +K AE + S + + F G
Sbjct: 129 NITSDKCYDNREWVWGYRENEPMGGYDPYSNSKGCAELVASAFRNSFFNPANYEQHGVGL 188
Query: 168 LIFRLANII--GKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIF 225
R N+I G + +I D + + N+ I+ + + + HV + ++G + +
Sbjct: 189 ASVRAGNVIGGGDWAKDRLIPDILRSFEN--NQQVIIRNPYSIRPWQHVLEPLSGYIVVA 246
Query: 226 E-YFKRQNKIFDVYNLG--NEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVK 282
+ + K + +N G +ED TV+ I + + G + G +
Sbjct: 247 QRLYTEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLWGDDASWLL-----DGENHPHEAH 301
Query: 283 FMLLSIEKAK-KTGWRPKMNSYEAVRRTVR 311
++ L KA + GW P+ E + R V+
Sbjct: 302 YLKLDCSKANMQLGWHPRWGLTETLGRIVK 331
>pir||G81242 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMB0063, NMB0079
[similarity] - Neisseria meningitidis (group B strain
MD58) >gi|7225283|gb|AAF40531.1| (AE002365)
dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis
MC58] >gi|7225297|gb|AAF40543.1| (AE002367)
dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis
MC58]
Length = 355
Score = 80.4 bits (195), Expect = 3e-14
Identities = 89/344 (25%), Positives = 151/344 (43%), Gaps = 51/344 (14%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRD 59
K+LVTGGAGFIGS +V ++ + + V +D L+ AG+LE+L +N + F + D+ D
Sbjct: 3 KILVTGGAGFIGSAVVRHIIRNTRDAVVNVDKLTYAGNLESLTEVADNPRYAFEQVDICD 62
Query: 60 YKIVKEAVDDV------EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR----- 108
+ +D V + V HLAA V S S +TN++ T+NLL+A R
Sbjct: 63 ----RAELDRVFAQYRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQ 118
Query: 109 ---ESNVKF-LVFTSSSTVYGDANVLPTPESY---GPLEPISVYGGAKLAAEALISGYAH 161
E + F S+ VYGD T + + P P S Y +K +++ L+ +
Sbjct: 119 MPSEQHEAFRFHHISTDEVYGDLG--GTDDLFTETAPYAPSSPYSASKASSDHLVRAWLR 176
Query: 162 IFGFRALIFRLANIIGKRSNHGVIYDFINKL-------KRNPNELEILGDGKQRKSYLHV 214
+G ++ +N G Y F KL + L + GDG Q + +L V
Sbjct: 177 TYGLPTIVTNCSNNYGP-------YHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFV 229
Query: 215 SDTINGILHIFEYFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFT 268
D + + + + + YN+G + VK I ++ E P ++
Sbjct: 230 EDHARALYQVV----TEGVVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYE 285
Query: 269 GGVDGGRGWKG-DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
+ + G DV++ + + + + GW P +R+TV+
Sbjct: 286 DLITFVQDRPGHDVRYAVDAAKIRRDLGWLPLETFESGLRKTVQ 329
>sp|P55294|RFBB_NEIMB DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437244|pir||S42431 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Neisseria meningitidis
(isolate B1940) >gi|388933|gb|AAA63157.1| (L09188)
TDP-glucose-dehydratase [Neisseria meningitidis]
Length = 360
Score = 79.2 bits (192), Expect = 6e-14
Identities = 88/339 (25%), Positives = 150/339 (43%), Gaps = 43/339 (12%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRDY 60
+LVTGGAGFIGS +V ++ + + V LD L+ AG+LE+L +N + F + D+ D
Sbjct: 9 ILVTGGAGFIGSAVVRHIIRNTQDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICDR 68
Query: 61 KIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR--------ES 110
+ A + V HLAA V S S +TN++ T+NLL+A R E
Sbjct: 69 AELDRVFAQHRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPSEQ 128
Query: 111 NVKF-LVFTSSSTVYGDANVLPTPESY---GPLEPISVYGGAKLAAEALISGYAHIFGFR 166
+ F S+ VYGD + T + + P P S Y +K +++ L+ + +G
Sbjct: 129 HEAFRFHHISTDEVYGDLH--GTDDLFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLP 186
Query: 167 ALIFRLANIIGKRSNHGVIYDFINKL-------KRNPNELEILGDGKQRKSYLHVSDTIN 219
++ +N G Y F KL + L + GDG Q + +L V D
Sbjct: 187 TIVTNCSNNYGP-------YHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHAR 239
Query: 220 GILHIFEYFKRQNKIFDVYNLGNE----DWITVKEIAEIVSEEMGLSPK--FKFTGGVDG 273
+ + + + + YN+G + VK I ++ E + P ++ +
Sbjct: 240 ALYQVV----TEGVVGETYNIGGHNEKANIEVVKTICTLLEELVPEKPAGVARYEDLITF 295
Query: 274 GRGWKG-DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
+ G DV++ + + + + GW P +R+TV+
Sbjct: 296 VQDRPGHDVRYAVDAAKIRRDLGWLPLETFESGLRKTVQ 334
>gi|9631863 similar to Mycobacterium ORF, corresponds to GenBank Accession
Number Z79701 [Paramecium bursaria Chlorella virus 1]
>gi|7461438|pir||T17792 hypothetical protein A295L -
Chlorella virus PBCV-1 >gi|1181458|gb|AAC96663.1|
(U42580) similar to Mycobacterium ORF, corresponds to
GenBank Accession Number Z79701 [Paramecium bursaria
Chlorella virus 1]
Length = 317
Score = 78.8 bits (191), Expect = 8e-14
Identities = 78/324 (24%), Positives = 136/324 (41%), Gaps = 39/324 (12%)
Query: 2 KVLVTGGAGFIGSHLVDRLMEDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRDYK 61
K+ V G G +GS LV L ++GY ++ S + L+ + E F + +Y
Sbjct: 8 KIYVAGHTGMVGSSLVRLLQKEGYT-----NIITRSSKELDLTNQQEVTAFFEMETPEYV 62
Query: 62 IVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
+ A V + AN +S + + + N++I N++ A + NVK LVF SS
Sbjct: 63 FLAAAK-----VGGIHAN-----NSFGGDFIRD-NLMIQTNVIHASKTFNVKKLVFLGSS 111
Query: 122 TVYGDANVLPTPESY---GPLEPIS-VYGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
+Y + P E Y G LEP + Y ++A + Y FG + N+ G
Sbjct: 112 CIYPKESPNPIKEEYLMTGFLEPTNKPYAIERIAGIEMCDAYRKQFGCNFVSVMPTNLSG 171
Query: 178 KRSNHG---------VIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYF 228
+ +I F + +++ G G R+ +LHV D G+L + E +
Sbjct: 172 PNDRYDLQNGHVFPVLIRKFYEAMINKVPSVKLWGTGIARREFLHVDDLARGLLIVMEKY 231
Query: 229 KRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSI 288
I N+G +++ E+AE+V + +G + + G K L+
Sbjct: 232 NEPGPI----NIGYGSDVSISELAELVRDIVGYKGAIIYDTYMPDGTLKK------LIDS 281
Query: 289 EKAKKTGWRPKMNSYEAVRRTVRE 312
K K GW PK++ + ++ V +
Sbjct: 282 TKIKSLGWEPKISLIDNIKLCVED 305
>sp|P37761|RFBB_NEIGO DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|628590|pir||S47045 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Neisseria gonorrhoeae
>gi|520896|emb|CAA83652.1| (Z32742) dTDP-D-glucose
4,6-dehydratase [Neisseria gonorrhoeae]
>gi|1333793|emb|CAA79718.1| (Z21508) dTDP-D-glucose
4,6-dehydratase [Neisseria gonorrhoeae]
Length = 346
Score = 77.6 bits (188), Expect = 2e-13
Identities = 88/338 (26%), Positives = 151/338 (44%), Gaps = 41/338 (12%)
Query: 3 VLVTGGAGFIGSHLVDRLMEDGYEVRV-LDDLS-AGSLENLNRWLENENFEFIRGDMRDY 60
+LVTGGAGFIGS +V ++++ + V LD L+ AG+LE+L +N + F + D+ D
Sbjct: 9 ILVTGGAGFIGSAVVRHIIQNTRDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICD- 67
Query: 61 KIVKEAVDDV------EVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR------ 108
+ +D V + V HLAA V + S TN++ T++LL+A R
Sbjct: 68 ---RAELDRVFAQYRPDAVMHLAAESHVDRAIGSAGEFIRTNIVGTFDLLEAARAYWQQM 124
Query: 109 --ESNVKF-LVFTSSSTVYGDANVLPTPESY---GPLEPISVYGGAKLAAEALISGYAHI 162
E F S+ VYGD + T + + P P S Y +K AA+ L+ +
Sbjct: 125 PSEKREAFRFHHISTDEVYGDLH--GTDDLFTETTPYAPSSPYSASKAAADHLVRAWQRT 182
Query: 163 FGFRALIFRLANIIGKRS--NHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTING 220
+ +++ +N G R + +N L P L + GDG Q + +L V D
Sbjct: 183 YRLPSIVSNCSNNYGPRQFPEKLIPLMILNALSGKP--LPVYGDGAQIRDWLFVEDHARA 240
Query: 221 ILHIFEYFKRQNKIFDVYNLGNEDWIT----VKEIAEIVSEEMGLSPK--FKFTGGVDGG 274
+ + + + + YN+G + T VK I ++ E P ++ +
Sbjct: 241 LYQVV----TEGVVGETYNIGGHNEKTNLEVVKTICALLEELAPEKPAGVARYEDLITFV 296
Query: 275 RGWKG-DVKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
+ G D ++ + + + + GW P +R+TV+
Sbjct: 297 QDRPGHDARYAVDAAKIRRDLGWLPLETFESGLRKTVQ 334
>gb|AAC60774.1| (U46859) Fcl [Yersinia enterocolitica (type 0:8)]
Length = 321
Score = 74.5 bits (180), Expect = 2e-12
Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 32/271 (11%)
Query: 65 EAVDDVEVVFHLAANPEVRISSQS---PELLYETNVLITYNLLQAIRESNVKFLVFTSSS 121
EA+D+V +LAA I + + E +YE N++I N++ A + + L+F SS
Sbjct: 54 EAIDEV----YLAAAKVGGIQANNNYPAEFIYE-NLMIECNIINAAHMAGIHKLLFLGSS 108
Query: 122 TVYGDANVLPTPESY---GPLEPISV-YGGAKLAAEALISGYAHIFGFRALIFRLANIIG 177
+Y P ES G LEP + Y AK+A L Y + N+ G
Sbjct: 109 CIYPKMADQPMSESTLLTGVLEPTNEPYAIAKIAGIKLCESYNRQYNRDYRSVMPTNLYG 168
Query: 178 KRSNH---------GVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFE-- 226
+ N ++ F RN NE+ + G GK + +LHV D +++ E
Sbjct: 169 ENDNFHPDNSHVIPALLRRFHEAKMRNDNEIIVWGSGKPMREFLHVDDMAAASIYVMELA 228
Query: 227 ---YFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKF 283
Y + N+G T++E+AE +++ +G S K F G K
Sbjct: 229 DDIYAANTQPMLSHINVGTGIDCTIRELAETIAQVVGFSGKLVFDSSKPDGAPRK----- 283
Query: 284 MLLSIEKAKKTGWRPKMNSYEAVRRTVRELL 314
L+ + + K GWR +++ + ++ T + L
Sbjct: 284 -LMDVSRLDKLGWRYQISLEKGLKMTYQWFL 313
>gb|AAD05454.1| (AF064070) putative dTDP-D-glucose 4,6-dehydratase [Burkholderia
pseudomallei]
Length = 353
Score = 74.5 bits (180), Expect = 2e-12
Identities = 83/331 (25%), Positives = 138/331 (41%), Gaps = 30/331 (9%)
Query: 3 VLVTGGAGFIGSHLV-DRLMEDGYEVRVLDDLS-AGSLENLNRWLENENFEFIRGDMRDY 60
+LVTGGAGFIG++ V D L + V +D L+ AG+L L N F R D+ D
Sbjct: 2 ILVTGGAGFIGANFVLDWLAQSDEAVLNVDKLTYAGNLGTLKSLQGNPKHVFARVDICDR 61
Query: 61 KIVKE--AVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRE--------- 109
+ A + H AA V S P +TNV+ T+ LL+A R+
Sbjct: 62 AAIDALLAQHKPRAIVHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSALGPDA 121
Query: 110 -SNVKFLVFTSSSTVYGDANVL-PTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRA 167
+ +FL S+ V+G + P P P S Y K ++ L+ Y H +G
Sbjct: 122 KAAFRFL-HVSTDEVFGSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPV 180
Query: 168 LIFRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEY 227
L +N G + + L + GDG+ + +L+V D + I +
Sbjct: 181 LTTNCSNNYGPYQFPEKLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVL-- 238
Query: 228 FKRQNKIFDVYNLG------NEDWI-TVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGD 280
+ + YN+G N D + T+ ++ + + G S + + T D D
Sbjct: 239 --ARGVPGETYNVGGWNEKKNLDVVHTLCDLLDEARPKAGGSYRDQITYVTDRP---GHD 293
Query: 281 VKFMLLSIEKAKKTGWRPKMNSYEAVRRTVR 311
++ + + + ++ GW+P + +TVR
Sbjct: 294 RRYAIDARKLERELGWKPAETFETGLAKTVR 324
>sp|O52325|YFBG_SALTY HYPOTHETICAL 73.6 KDA PROTEIN IN AIS-PMRD INTERGENIC REGION
>gi|2921421|gb|AAC04772.1| (AF036677) unknown
[Salmonella typhimurium]
Length = 660
Score = 74.1 bits (179), Expect = 2e-12
Identities = 88/345 (25%), Positives = 161/345 (46%), Gaps = 45/345 (13%)
Query: 1 MKVLVTGGAGFIGSHLVDRLM-EDGYEVRVLDDLSAGSLENLNRWLENENFEFIRGDMRD 59
++VL+ G GFIG+HL +RL+ E+ YEV +D GS ++R+L + F F+ GD+
Sbjct: 316 IRVLILGVNGFIGNHLTERLLNEENYEVYGMD---IGS-NAISRFLLHPRFHFVEGDISI 371
Query: 60 Y-KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKFLVFT 118
+ + ++ V +VV L A +++P ++E + +++ + K +VF
Sbjct: 372 HSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYR-KRVVFP 430
Query: 119 SSSTVYGDANVLPTPES-----YGPL-EPISVYGGAKLAAEALISGYAHIFGFRALIFRL 172
S+S VYG E GP+ +P +Y +K + +I Y G R +FR
Sbjct: 431 STSEVYGMCTDASFDEDKSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLRFTLFRP 490
Query: 173 ANIIGKR----------SNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGIL 222
N +G R S+ + +N ++ P ++++ G+Q++ + + D I +
Sbjct: 491 FNWMGPRLDSLNAARIGSSRAITQLILNLVEGTP--IKLIDGGQQKRCFTDIRDGIEALF 548
Query: 223 HIF--EYFKRQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSP---KFKFTGGVD----- 272
I + + KI ++ N NE +++E+A ++ + P F G
Sbjct: 549 RIIVNDGDRCDGKIINIGNPDNE--ASIQELATLLLDSFDKHPLRCHFPPFAGFQVVESR 606
Query: 273 --GGRGWKGDVKFMLLSIEKAKK-TGWRPKMNSYEAVRRTVRELL 314
G+G++ DV SI+ A++ GW P + A+R TV E L
Sbjct: 607 SYYGKGYQ-DVAHRKPSIDNARRCLGWEPSI----AMRDTVEETL 646
>pir||G69142 GDP-D-mannose dehydratase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621389|gb|AAB84839.1| (AE000818)
GDP-D-mannose dehydratase [Methanobacterium
thermoautotrophicum]
Length = 348
Score = 72.2 bits (174), Expect = 8e-12
Identities = 85/319 (26%), Positives = 141/319 (43%), Gaps = 19/319 (5%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVR-VLDDLSAGSLENLNRWLENENFEFIRGDMRDYKI 62
L+TG G G++L L+E GYEV + LS + L + + D+ D
Sbjct: 5 LITGITGQDGAYLAKFLLEKGYEVYGIYRRLSTPNFWRLQYLEIFDRINLVPADLTDEFS 64
Query: 63 VKEA--VDDVEVVFHLAANPEVRISSQSP-ELLYETNVLITYNLLQAIRESNVKFLVF-T 118
+ E+ + D + V+HLAA V S + P + T V +T ++L+AIR N +
Sbjct: 65 LLESLKISDADEVYHLAAQSFVGTSFEQPTSTAHVTGVAVT-SMLEAIRHYNPHIRFYQA 123
Query: 119 SSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAH---IFGFRALIFRLAN- 174
SSS +YGD + E+ P +P S Y AKL + Y IF ++F +
Sbjct: 124 SSSEIYGDGHTTILNEN-SPFKPSSPYAAAKLYGYWMTRIYREGYDIFACNGILFNHESP 182
Query: 175 IIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFKRQNKI 234
+ G I + K+ + +LG+ ++ + + D + + + Q+K
Sbjct: 183 LRGLEFVTRKISNTAAKIALGLEDELLLGNLDAKRDWGYAPDYVEAM-----HMMLQHKE 237
Query: 235 FDVYNLGNEDWITVKEIAEIVSEEMGLSPKFKFTGGVDGGRGWKGDVKFMLLSIEKAKKT 294
D + + + TV+E E EE+GL ++ VD DV ++ KA++
Sbjct: 238 PDDFVIATAETHTVREFCEKSFEELGLD--WQDYVKVDKRFFRPLDVNYLCGDYSKAREN 295
Query: 295 -GWRPKMNSYEAVRRTVRE 312
GW+PK E V+ VRE
Sbjct: 296 LGWQPKTKFEELVKIMVRE 314
>gb|AAD46729.1|AF078736_3 (AF078736) GDP-D-mannose dehydratase [Escherichia coli]
Length = 372
Score = 69.5 bits (167), Expect = 5e-11
Identities = 94/363 (25%), Positives = 147/363 (39%), Gaps = 65/363 (17%)
Query: 4 LVTGGAGFIGSHLVDRLMEDGYEVR-VLDDLSAGSLENLNR-----WLENENFEFIRGDM 57
L+TG G GS+L + L+E GYEV + S+ + E ++ L N GD+
Sbjct: 6 LITGITGQDGSYLAELLLEKGYEVHGIKRRASSFNTERVDHIYQDSHLANPKLFLHYGDL 65
Query: 58 RDY----KIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIR----E 109
D +I+KE D V++L A V +S +SPE + + + T LL+AIR E
Sbjct: 66 TDTSNLTRILKEVQPDE--VYNLGAMSHVAVSFESPEYTADVDAIGTLRLLEAIRILGLE 123
Query: 110 SNVKFLVFTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALI 169
KF S+S +YG +P E+ P P S Y AKL A + Y +G A
Sbjct: 124 KKTKFYQ-ASTSELYGLVQEIPQKET-TPFYPRSPYAVAKLYAYWITVNYRESYGMFACN 181
Query: 170 FRLANIIGKRSNHGVIYDFINKLKRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFK 229
L N R + K+ R + + G + YL D++ H +Y K
Sbjct: 182 GILFNHESPRRGETFV---TRKITRG---IANIAQGLDKCLYLGNMDSLRDWGHAKDYVK 235
Query: 230 RQNKIFDVYNLGNEDWI-------TVKEIAEIVSEEMGLSPKFKFTG-----------GV 271
Q + ED++ +V+E + +E++G+ F+ G G
Sbjct: 236 MQWMMLQQET--PEDFVIATGIQYSVREFVTMAAEQVGIELAFEGEGVNEKGVVVSVNGT 293
Query: 272 DGGRGWKGDVKFMLLSIEKA------------------KKTGWRPKMNSYEAVRRTVREL 313
D GDV ++S++ KK GW P++ E V+ V
Sbjct: 294 DAKAVNPGDV---IISVDPRYFRPAEVETLLGDPTNAHKKLGWSPEITLREMVKEMVSSD 350
Query: 314 LGV 316
L +
Sbjct: 351 LAI 353
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.140 0.404
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 121398428
Number of Sequences: 2977
Number of extensions: 5229599
Number of successful extensions: 16452
Number of sequences better than 1.0e-10: 356
Number of HSP's better than 0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 339
Number of HSP's that attempted gapping in prelim test: 15679
Number of HSP's gapped (non-prelim): 364
length of query: 317
length of database: 189,106,746
effective HSP length: 55
effective length of query: 262
effective length of database: 156,189,961
effective search space: 40921769782
effective search space used: 40921769782
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)