BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1303 (purA) DE:adenylosuccinate synthetase (purA)
(339 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||E75007 adenylosuccinate synthetase (pura) PAB1303 - Pyrococ... 688 0.0
sp|Q59726|PURA_PYRSS ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 672 0.0
sp|O58187|PURA_PYRHO ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 662 0.0
pir||S72276 adenylosuccinate synthase (EC 6.3.4.4) purA - Pyroco... 641 0.0
sp|Q57981|PURA_METJA ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 482 e-135
gi|11498447 adenylosuccinate synthetase (purA) [Archaeoglobus fu... 470 e-132
sp|O26712|PURA_METTH ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 448 e-125
gb|AAK40583.1| Adenylosuccinate synthase (IMP--aspartate ligase)... 302 3e-81
dbj|BAB07747.1| (AP001520) adenylosuccinate synthetase [Bacillus... 222 3e-57
pir||F81153 adenylosuccinate synthetase NMB0815 [imported] - Nei... 221 8e-57
pir||F81950 probable adenylosuccinate synthase (EC 6.3.4.4) NMA1... 220 1e-56
pir||A42280 adenylosuccinate synthase (EC 6.3.4.4) purA - Bacill... 215 6e-55
pir||G81296 adenylosuccinate synthase (EC 6.3.4.4) Cj1498c [impo... 215 8e-55
sp|O68581|PURA_FUSNU ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 214 1e-54
pir||A45027 adenylosuccinate synthase (EC 6.3.4.4) - fission yea... 213 2e-54
sp|Q02787|PURA_SCHPO ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 213 2e-54
gb|AAA70333.1| (M98805) adenylosuccinate synthetase [Schizosacch... 212 5e-54
sp|Q9X8P6|PURA_STRCO ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 211 9e-54
pir||B82803 adenylosuccinate synthetase XF0455 [imported] - Xyle... 208 6e-53
pir||C75567 adenylosuccinate synthase - Deinococcus radiodurans ... 208 6e-53
sp|P12283|PURA_ECOLI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 206 2e-52
pdb|1ADE|A Chain A, Structure Of Adenylosuccinate Synthetase Ph7... 206 2e-52
dbj|BAA89445.1| (AB003160) adenylosuccinate synthetase [Coryneba... 206 2e-52
pir||F82055 adenylosuccinate synthetase VC2602 [imported] - Vibr... 206 3e-52
sp|P40607|PURA_VIBPA ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 205 5e-52
pdb|1CG1|A Chain A, Structure Of The Mutant (K16q) Of Adenylosuc... 205 7e-52
sp|P21900|PURA_DICDI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 205 9e-52
pdb|1CG4|A Chain A, Structure Of The Mutant (R303l) Of Adenylosu... 204 1e-51
gb|AAA24446.1| (J04199) adenylosuccinate synthetase (EC 6.3.4.4)... 204 1e-51
pdb|1CG3|A Chain A, Structure Of The Mutant (R143l) Of Adenylosu... 204 1e-51
sp|P45283|PURA_HAEIN ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 203 3e-51
pir||F83027 adenylosuccinate synthetase PA4938 [imported] - Pseu... 202 6e-51
sp|O08381|PURA_MYCTU ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 202 6e-51
sp|O31047|PURA_EDWIC ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 201 7e-51
sp|P73290|PURA_SYNY3 ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 201 7e-51
sp|Q96529|PURA_ARATH ADENYLOSUCCINATE SYNTHETASE PRECURSOR (IMP-... 199 4e-50
pdb|1DJ2|A Chain A, Structures Of Adenylosuccinate Synthetase Fr... 199 4e-50
sp|P52151|PURA_THIFE ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 198 6e-50
gi|6324109 adenylosuccinate synthetase; Ade12p [Saccharomyces ce... 198 1e-49
sp|O69595|PURA_MYCLE ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 198 1e-49
sp|P29726|PURA_BACSU ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 197 2e-49
sp|Q9X0I1|PURA_THEMA ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 195 7e-49
sp|P91134|PURA_CAEEL PROBABLE ADENYLOSUCCINATE SYNTHETASE (IMP--... 192 4e-48
sp|O24578|PURA_MAIZE ADENYLOSUCCINATE SYNTHETASE PRECURSOR (IMP-... 190 1e-47
sp|O67321|PURA_AQUAE ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 190 2e-47
sp|O24396|PURA_WHEAT ADENYLOSUCCINATE SYNTHETASE PRECURSOR (IMP-... 188 7e-47
pdb|1DJ3|A Chain A, Structures Of Adenylosuccinate Synthetase Fr... 188 7e-47
gb|AAA75455.1| (L43054) adenylosuccinate synthetase [Brucella ab... 182 4e-45
sp|P52004|PURA_BRUAB ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 182 4e-45
gb|AAG01122.1|AF273333_7 (AF273333) BAC19.7 [Lycopersicon escule... 182 5e-45
sp|Q9ZMI1|PURA_HELPJ ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 177 2e-43
pir||S77471 adenylosuccinate synthase (EC 6.3.4.4) - Synechocyst... 177 2e-43
gb|AAG19487.1| (AE005041) adenylosuccinate synthase; PurA [Halob... 174 1e-42
sp|P57629|PURA_BUCAI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 172 5e-42
sp|P56137|PURA_HELPY ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 170 2e-41
sp|P52150|PURA_SPICI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 166 3e-40
emb|CAC12488.1| (AL445067) probable adenylosuccinate synthetase ... 164 1e-39
gi|6671519 adenylosuccinate synthetase 1, muscle [Mus musculus] ... 163 2e-39
prf||2122208A adenylosuccinate synthetase:ISOTYPE=muscle [Mus mu... 163 2e-39
sp|Q9Y0Y2|PURA_DROME ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 163 2e-39
gb|AAF55811.1| (AE003732) BcDNA:LD32788 gene product [Drosophila... 163 2e-39
pir||AJMSDS adenylosuccinate synthase (EC 6.3.4.4), muscle - mouse 161 1e-38
gb|AAF06822.1|AF095282_1 (AF095282) adenylosuccinate synthase [P... 151 1e-35
pir||S21166 adenylosuccinate synthase (EC 6.3.4.4) - human 145 7e-34
gi|4557271 adenylosuccinate synthase; Adenylosuccinate synthetas... 145 7e-34
gi|6671521 adenylosuccinate synthetase 2, non muscle [Mus muscul... 142 6e-33
prf||2122208B adenylosuccinate synthetase:ISOTYPE=nonmuscle [Mus... 141 1e-32
sp|P96771|PURA_ACTAC ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 118 9e-26
sp|O30549|PURA_PSEST ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE... 104 2e-21
>pir||E75007 adenylosuccinate synthetase (pura) PAB1303 - Pyrococcus abyssi
(strain Orsay) >gi|5459013|emb|CAB50499.1| (AJ248288)
adenylosuccinate synthetase (purA) [Pyrococcus abyssi]
Length = 339
Score = 688 bits (1757), Expect = 0.0
Identities = 339/339 (100%), Positives = 339/339 (100%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG
Sbjct: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL
Sbjct: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG 180
HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG
Sbjct: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG 180
Query: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME 240
FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME
Sbjct: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME 240
Query: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK 300
EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK
Sbjct: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK 300
Query: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI
Sbjct: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
>sp|Q59726|PURA_PYRSS ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE)
Length = 339
Score = 672 bits (1714), Expect = 0.0
Identities = 327/339 (96%), Positives = 336/339 (98%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
MPS+IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG
Sbjct: 1 MPSMIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
FMQRKARLLVGAGVLVDPEVFFHELEHLK+FNVK+RVGIDYRCAIIE KHKELDR+NGYL
Sbjct: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKDFNVKERVGIDYRCAIIEPKHKELDRSNGYL 120
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG 180
HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAE+NDALDEGALVLVEGTQG
Sbjct: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEVNDALDEGALVLVEGTQG 180
Query: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME 240
FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVD+VIVVFKSFPTRVGAGPFPTEMPME
Sbjct: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDEVIVVFKSFPTRVGAGPFPTEMPME 240
Query: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK 300
EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLA+TMLDKYDKEAFGVTDYDK
Sbjct: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAVTMLDKYDKEAFGVTDYDK 300
Query: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
LPRKAKEFIEEIEE+VGVPVGLIKTGPELEHIID R+ I
Sbjct: 301 LPRKAKEFIEEIEEKVGVPVGLIKTGPELEHIIDRRDTI 339
>sp|O58187|PURA_PYRHO ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7520887|pir||G71154 probable
adenylosuccinate synthetase - Pyrococcus horikoshii
>gi|3256841|dbj|BAA29524.1| (AP000002) 339aa long
hypothetical adenylosuccinate synthetase [Pyrococcus
horikoshii]
Length = 339
Score = 662 bits (1690), Expect = 0.0
Identities = 320/339 (94%), Positives = 333/339 (97%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
MPS+IVVGGQWGDEGKGSI+AYL+LHDEPEIIARGGVGTNAGHSV INGKKYAVRQ+PTG
Sbjct: 1 MPSVIVVGGQWGDEGKGSIVAYLSLHDEPEIIARGGVGTNAGHSVVINGKKYAVRQIPTG 60
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
FMQ KARLL+GAGVLVDPEVFFHELE LK+FNVKDRVGIDYRCAIIEEKHK+LDRTNGYL
Sbjct: 61 FMQTKARLLIGAGVLVDPEVFFHELEQLKDFNVKDRVGIDYRCAIIEEKHKQLDRTNGYL 120
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG 180
HGKIGTTGSGCGPANADRVMRKAKQAKD+KELEPYLTDVA EINDALDEG+LVLVEGTQG
Sbjct: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDVKELEPYLTDVAQEINDALDEGSLVLVEGTQG 180
Query: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME 240
FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVD+VIVVFKSFPTRVGAGPFPTEMPME
Sbjct: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDEVIVVFKSFPTRVGAGPFPTEMPME 240
Query: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK 300
EADRLGLVEYGTVTGRRRRVGWFDFEMARYSAR+NGATMLA+TMLDKYDKEAFGVTDYDK
Sbjct: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARINGATMLAVTMLDKYDKEAFGVTDYDK 300
Query: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIID R+ I
Sbjct: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDRRDTI 339
>pir||S72276 adenylosuccinate synthase (EC 6.3.4.4) purA - Pyrococcus sp.
(strain ST700) >gi|1419160|emb|CAA63823.1| (X94001)
adenylosuccinate synthetase [Pyrococcus sp.]
Length = 338
Score = 641 bits (1635), Expect = 0.0
Identities = 315/339 (92%), Positives = 325/339 (94%), Gaps = 1/339 (0%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
MPS+IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG
Sbjct: 1 MPSMIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
FMQRKARLLVGAGVLVDPEVFFHELEHLK+FNVK+RVGIDYRCAIIE KHKELDR+NGYL
Sbjct: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKDFNVKERVGIDYRCAIIEPKHKELDRSNGYL 120
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG 180
HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAE+NDALDEGALVLVEGTQG
Sbjct: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEVNDALDEGALVLVEGTQG 180
Query: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME 240
FGLSLYYGTYPYVTSKDV + G TRVD+VIVVFKSFPTRVGAGPFPTEMPME
Sbjct: 181 FGLSLYYGTYPYVTSKDVCLFD-SCGCGNRATRVDEVIVVFKSFPTRVGAGPFPTEMPME 239
Query: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK 300
EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLA+TMLDKYDKEAFGVTDYDK
Sbjct: 240 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAVTMLDKYDKEAFGVTDYDK 299
Query: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
LPRKAKEFIEEIEE+VGVPVGLIKTGPELEHIID R+ I
Sbjct: 300 LPRKAKEFIEEIEEKVGVPVGLIKTGPELEHIIDRRDTI 338
>sp|Q57981|PURA_METJA ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|2127748|pir||A64370 adenylosuccinate
synthase (EC 6.3.4.4) - Methanococcus jannaschii
>gi|1591267|gb|AAB98554.1| (U67505) adenylosuccinate
synthetase (purA) [Methanococcus jannaschii]
Length = 345
Score = 482 bits (1227), Expect = e-135
Identities = 231/335 (68%), Positives = 278/335 (82%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
I+VGGQWGDEGKG II+Y+ D+P IIARGGVG NAGH+V I GK Y +R +PTGF +
Sbjct: 11 IIVGGQWGDEGKGKIISYICDKDKPSIIARGGVGPNAGHTVNIGGKSYGIRMIPTGFPYK 70
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYLHGKI 124
+A+L +GAGVLVDPEV E+E LK+FNVK+R+ +DYRC IIEEKHK +DR + +L +I
Sbjct: 71 EAKLAIGAGVLVDPEVLLKEVEMLKDFNVKERLIVDYRCGIIEEKHKIMDRKDEHLAKEI 130
Query: 125 GTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQGFGLS 184
GTTGSGCGPAN DRV+R KQAKDI+EL+ +L DV+ E+N+ALD G VL+EGTQG LS
Sbjct: 131 GTTGSGCGPANVDRVLRILKQAKDIEELKEFLGDVSEEVNNALDRGENVLIEGTQGTLLS 190
Query: 185 LYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADR 244
LYYGTYPYVTSKD TASS AADVGIGPT+VD+VIVVFK+FPTRVGAGPFPTEM +EEA+
Sbjct: 191 LYYGTYPYVTSKDTTASSFAADVGIGPTKVDEVIVVFKTFPTRVGAGPFPTEMSLEEAES 250
Query: 245 LGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDKLPRK 304
LG+VEYGTVTGRRRRVG+FDFE+AR + R+NGAT +A+T LDKYDKE +GVT+Y+KL K
Sbjct: 251 LGIVEYGTVTGRRRRVGYFDFELARKACRLNGATQIALTGLDKYDKECYGVTEYNKLSEK 310
Query: 305 AKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
AKEFI +IEE GVPV +I TGPE+ IDLR +
Sbjct: 311 AKEFINKIEEVTGVPVTIISTGPEMHQTIDLRNEL 345
>gi|11498447 adenylosuccinate synthetase (purA) [Archaeoglobus fulgidus]
>gi|6685810|sp|O29417|PURA_ARCFU ADENYLOSUCCINATE
SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)
>gi|7482897|pir||A69355 adenylosuccinate synthetase
(purA) homolog - Archaeoglobus fulgidus
>gi|2649766|gb|AAB90398.1| (AE001046) adenylosuccinate
synthetase (purA) [Archaeoglobus fulgidus]
Length = 337
Score = 470 bits (1197), Expect = e-132
Identities = 229/337 (67%), Positives = 279/337 (81%), Gaps = 3/337 (0%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M + I+VGG WGDEGKG I+A++A D+P IIARGGVG NAGH+V I+G+K+ VR +P+G
Sbjct: 1 MGATIIVGGFWGDEGKGKIVAHVAHSDKPVIIARGGVGPNAGHTVEIDGQKFGVRMIPSG 60
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
F+ + A+LL+GAGVLV+PEVF E+E LK V DR +DYRCAIIE KH E D+ + +L
Sbjct: 61 FVYKDAKLLIGAGVLVNPEVFLKEVELLK---VGDRARVDYRCAIIEPKHIEADKGSEHL 117
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG 180
KIGTTG+GCGPAN DRV R AKQAKDI EL+ YL DV E+N A++ G VL+EG+QG
Sbjct: 118 SKKIGTTGTGCGPANVDRVNRVAKQAKDIPELKDYLADVPLEVNQAIENGQFVLIEGSQG 177
Query: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME 240
FGLSLYYGTYPYVTSKD TAS++A+DVG+GPTRVDDVIVVFK FPTRVGAGPFPTEMP E
Sbjct: 178 FGLSLYYGTYPYVTSKDTTASAIASDVGVGPTRVDDVIVVFKCFPTRVGAGPFPTEMPQE 237
Query: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK 300
EA++LG+VEYGTVTGRRRR+G++D E ARYSA VNGAT +AIT +DK DKE +GVT+++K
Sbjct: 238 EAEKLGIVEYGTVTGRRRRIGYWDGEFARYSAMVNGATQVAITGVDKLDKECYGVTEWEK 297
Query: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRE 337
L KAK+FIE++EE V VPV LI TGPEL+ IIDLR+
Sbjct: 298 LTPKAKKFIEQVEEDVRVPVTLISTGPELKQIIDLRK 334
>sp|O26712|PURA_METTH ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7482032|pir||G69181 adenylosuccinate
synthetase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621696|gb|AAB85121.1| (AE000843)
adenylosuccinate synthetase [Methanobacterium
thermoautotrophicum]
Length = 340
Score = 448 bits (1141), Expect = e-125
Identities = 215/339 (63%), Positives = 260/339 (76%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M ++VGG WGDEGKG I YL +D+P IIAR GVG NAGHSV G KY +R P+G
Sbjct: 1 MTCTVLVGGGWGDEGKGKCITYLCYNDKPSIIARAGVGPNAGHSVEFRGDKYGLRLTPSG 60
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
F ARLL+GAGVLVDPEVF HE+E+L +++V DR G+DYRCAIIE KHKE D+++ YL
Sbjct: 61 FFHEDARLLIGAGVLVDPEVFLHEMEYLSKYSVADRTGVDYRCAIIERKHKEQDQSSSYL 120
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQG 180
KIG+TG+GCGPANA+RVMR AK A++++EL +LTDV E+N+ALDEG V VEG+QG
Sbjct: 121 SKKIGSTGTGCGPANAERVMRTAKLAREVEELGDFLTDVPLEVNEALDEGEDVFVEGSQG 180
Query: 181 FGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME 240
FGLSLYYGTYPYVTSKD TAS+ AADVGIGPTRVD+VI VFKS+ TRVG GPFPTE+ E
Sbjct: 181 FGLSLYYGTYPYVTSKDTTASTAAADVGIGPTRVDEVIAVFKSYITRVGEGPFPTEISQE 240
Query: 241 EADRLGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDK 300
EA+ +GL EYGTVTGRRRR+G FD EMAR S +NGAT +A+T +D+ E V +Y
Sbjct: 241 EAEEMGLEEYGTVTGRRRRIGLFDMEMARESCMINGATQIAVTCVDRLYPECERVREYSD 300
Query: 301 LPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
L + K FIE+IE GVPV +I TGP LE IDLR+ +
Sbjct: 301 LSAEVKRFIEDIESATGVPVTIISTGPSLEDTIDLRDEL 339
>gb|AAK40583.1| Adenylosuccinate synthase (IMP--aspartate ligase) (purA)
[Sulfolobus solfataricus]
Length = 335
Score = 302 bits (766), Expect = 3e-81
Identities = 153/335 (45%), Positives = 221/335 (65%), Gaps = 4/335 (1%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+++GG +GDEGKG + AYL + D P++ R G NAGH+V +G+ + +R +P+ F+ +
Sbjct: 4 LIIGGFFGDEGKGKVAAYLGIKDRPKLSVRTG-SINAGHTVTYSGRIWKLRIIPSAFINK 62
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYLHGKI 124
L +G G L + F E+ +E DR+ ID II E ++ + YL I
Sbjct: 63 STELALGPGALTSLDALFKEM---RETETYDRLYIDSHVGIITEDEIRDEKNDPYLMNVI 119
Query: 125 GTTGSGCGPANADRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQGFGLS 184
G+TG G G A + R++RK K AKD KELE ++ DV +I D LD G +L+EGTQG LS
Sbjct: 120 GSTGQGVGYAESKRILRKLKLAKDYKELEKFIIDVPNKILDYLDNGHNILIEGTQGHYLS 179
Query: 185 LYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADR 244
LY+G YPYVTS++ TAS V ++ GIGP VD +I+ FKS+ TRVG GP E+ E+A +
Sbjct: 180 LYHGEYPYVTSRNTTASGVLSEAGIGPKYVDHIIITFKSYVTRVGKGPLEGELTEEDAKK 239
Query: 245 LGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEAFGVTDYDKLPRK 304
LGL EYGTVTGR RRV F+ ++AR + R+N AT++AIT LD K+A+ V +Y+KLP +
Sbjct: 240 LGLTEYGTVTGRLRRVAPFNVKLAREAIRINSATIVAITKLDTLFKDAYRVREYEKLPAE 299
Query: 305 AKEFIEEIEERVGVPVGLIKTGPELEHIIDLRENI 339
A+++++E+EE + P+GLI TG + +IDLRE +
Sbjct: 300 ARKWLDELEEELKTPIGLIGTGEDAYDMIDLREEV 334
>dbj|BAB07747.1| (AP001520) adenylosuccinate synthetase [Bacillus halodurans]
Length = 428
Score = 222 bits (561), Expect = 3e-57
Identities = 140/418 (33%), Positives = 203/418 (48%), Gaps = 92/418 (22%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M S++VVG QWGDEGKG I YL+ ++ E++AR G NAGH++ NG+KY + +P+G
Sbjct: 1 MSSVVVVGTQWGDEGKGKITDYLS--EKAEVVARYQGGNNAGHTIVFNGEKYKLHLIPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDRTNGY 119
++G G+++DP+ EL +L E NV + I R +I H +LD
Sbjct: 59 IFYSDKVCVIGNGMVIDPKALVEELAYLHERNVDTSNLRISNRAHVILPYHLKLDIVEEE 118
Query: 120 LHG--KIGTTGSGCGPANADRVMRKAKQAKDI---------------------------- 149
G KIGTT G GPA D+ R + D+
Sbjct: 119 RKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDKEVFEEKLERNLVEKNRLFEKYYEVG 178
Query: 150 ---------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
+++ Y+ D + +NDALDEG VL EG QG L + GTYP+VT
Sbjct: 179 GFNKEDILDEYYEYGQQIARYVCDTSVVLNDALDEGRRVLFEGAQGVMLDIDQGTYPFVT 238
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGT 252
S + A V G+GP+++ V+ V K++ TRVG GPFPTE+ E D++ V EYGT
Sbjct: 239 SSNPIAGGVTIGSGVGPSKIHHVVGVSKAYTTRVGDGPFPTELHDEIGDQIREVGNEYGT 298
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLD--------------KY---------- 288
TGR RRVGWFD + R++ RV+G T L++ +D KY
Sbjct: 299 TTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVLTGIKTLKICTAYKYRGEVVEEFPA 358
Query: 289 ------------------DKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPE 328
D++ GVT D+LP A+ +IE + + G+P+ + GP+
Sbjct: 359 SLKVLAECEPVYEELPGWDEDITGVTSLDELPVNARHYIERVSQLTGIPLTIFSVGPD 416
>pir||F81153 adenylosuccinate synthetase NMB0815 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226050|gb|AAF41228.1| (AE002435) adenylosuccinate
synthetase [Neisseria meningitidis MC58]
Length = 434
Score = 221 bits (558), Expect = 8e-57
Identities = 143/428 (33%), Positives = 204/428 (47%), Gaps = 99/428 (23%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ +LA +E + R G NAGH++ + GKK +R +P+G +
Sbjct: 6 NVVVIGAQWGDEGKGKIVDWLA--EEAGGVVRFQGGHNAGHTLVVGGKKTILRLIPSGIL 63
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEFNVKD---RVGIDYRCAIIEEKHKELDRTNGY 119
+G+GV+V PE E++ L VK+ R+ I C +I H LD+
Sbjct: 64 HESLDCFIGSGVVVSPEALLGEIDELNAAGVKNVEGRLKIAPTCPLILPYHIALDQAREA 123
Query: 120 LHGK--IGTTGSGCGPANADRVMRKAKQAKDIKELE------------------------ 153
GK IGTTG G GPA D+V R+A +A D+ E
Sbjct: 124 SRGKGKIGTTGRGIGPAYEDKVARRAIRAADLLHPEKLREKLDAVLAYYNVQLQHLHNAE 183
Query: 154 -------------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
P +TDV+ +N+ G +L EG QG L + YGTYP+VT
Sbjct: 184 PVKAEDVMAVIEKVAPRIAPMITDVSRVLNEKNKNGEKLLFEGAQGALLDIDYGTYPFVT 243
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV----EY 250
S + A + +A G+GP +D V+ + K++ TRVG+GPFPTE+ E +GL E+
Sbjct: 244 SSNCLAGAASAGAGVGPQMLDYVLGIVKAYTTRVGSGPFPTELFDEVG--VGLAERGHEF 301
Query: 251 GTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD--------------------- 289
G+VTGR RR GWFD + S ++NG + + IT LD D
Sbjct: 302 GSVTGRARRCGWFDAAALKRSIQINGISGMCITKLDVMDGVETINICVGYELPDGGKTDI 361
Query: 290 ----------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGP 327
+ FGV DY LP AK +++ IEE G PV ++ TGP
Sbjct: 362 LPCGSDAVETCKPIYETMPGWRESTFGVKDYGALPENAKAYLKRIEEVCGAPVAIVSTGP 421
Query: 328 ELEHIIDL 335
+ E I L
Sbjct: 422 DREETIVL 429
>pir||F81950 probable adenylosuccinate synthase (EC 6.3.4.4) NMA1024 [imported]
- Neisseria meningitidis (group A strain Z2491)
>gi|7379726|emb|CAB84293.1| (AL162754) putative
adenylosuccinate synthetase [Neisseria meningitidis
Z2491]
Length = 432
Score = 220 bits (556), Expect = 1e-56
Identities = 142/426 (33%), Positives = 202/426 (47%), Gaps = 95/426 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ +LA +E + R G NAGH++ + GKK +R +P+G +
Sbjct: 4 NVVVIGAQWGDEGKGKIVDWLA--EEAGGVVRFQGGHNAGHTLVVGGKKTILRLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEFNVKD---RVGIDYRCAIIEEKHKELDRTNGY 119
+G+GV+V PE E++ L VK+ R+ I C +I H LD+
Sbjct: 62 HESLDCFIGSGVVVSPEALLGEIDELNAAGVKNVEGRLKIAPTCPLILPYHIALDQAREA 121
Query: 120 LHGK--IGTTGSGCGPANADRVMRKAKQAKDIKELE------------------------ 153
GK IGTTG G GPA D+V R+A +A D+ E
Sbjct: 122 SRGKGKIGTTGRGIGPAYEDKVARRAIRAADLLHPEKLREKLDAVFAYYNVQLQHLHNAE 181
Query: 154 -------------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
P +TDV+ +N+ G +L EG QG L + YGTYP+VT
Sbjct: 182 SVKAEDVMAVIEKVAPRITPMITDVSRVLNEKNKNGEKLLFEGAQGALLDIDYGTYPFVT 241
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGT 252
S + A + +A G+GP +D V+ + K++ TRVG+GPFPTE+ E L E+G+
Sbjct: 242 SSNCLAGAASAGAGVGPQMLDYVLGIVKAYTTRVGSGPFPTELFDEVGAGLAERGHEFGS 301
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD----------------------- 289
VTGR RR GWFD + S ++NG + + IT LD D
Sbjct: 302 VTGRARRCGWFDAAALKRSIQINGISGMCITKLDVMDGVETINICVGYELPDGGKTDILP 361
Query: 290 --------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPEL 329
+ FGV YD LP AK +++ IEE G PV ++ TGP+
Sbjct: 362 CGSDAVEACKPIYETMPGWSESTFGVKSYDALPANAKAYLKRIEEVCGAPVAIVSTGPDR 421
Query: 330 EHIIDL 335
E I L
Sbjct: 422 EETIVL 427
>pir||A42280 adenylosuccinate synthase (EC 6.3.4.4) purA - Bacillus subtilis
>gi|467328|dbj|BAA05174.1| (D26185) adenylosuccinate
synthetase [Bacillus subtilis]
>gi|2636589|emb|CAB16079.1| (Z99124) adenylosuccinate
synthetase [Bacillus subtilis]
Length = 430
Score = 215 bits (542), Expect = 6e-55
Identities = 134/418 (32%), Positives = 198/418 (47%), Gaps = 92/418 (22%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M S++VVG QWGDEGKG I +L+ + E+IAR G NAGH++ +G Y + +P+G
Sbjct: 1 MSSVVVVGTQWGDEGKGKITDFLS--ENAEVIARYQGGNNAGHTIKFDGITYKLHLIPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDRTNGY 119
+ ++G G++VDP+ EL +L E NV D + I R +I H +LD
Sbjct: 59 IFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRAHVILPYHLKLDEVEEE 118
Query: 120 LHG--KIGTTGSGCGPANADRVMRKAKQAKDI---------------------------- 149
G KIGTT G GPA D+ R + D+
Sbjct: 119 RKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKLERNLEEKNRLLEKMYETE 178
Query: 150 ---------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
++++ Y+ D + +NDALDEG VL EG QG L + GTYP+VT
Sbjct: 179 GFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVLFEGAQGVMLDIDQGTYPFVT 238
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGT 252
S + A V G+GPT++ V+ V K++ TRVG GPFPTE+ E D++ V EYGT
Sbjct: 239 SSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGPFPTELKDEIGDQIREVGREYGT 298
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLD-------------------------- 286
TGR RRVGWFD + R++ RV+G T L++ +D
Sbjct: 299 TTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVLAGIETLKICVAYRYKGEIIEEFPA 358
Query: 287 ----------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPE 328
+ ++ G +LP A+ ++E + + G+P+ + GP+
Sbjct: 359 SLKALAECEPVYEEMPGWTEDITGAKSLSELPENARHYLERVSQLTGIPLSIFSVGPD 416
>pir||G81296 adenylosuccinate synthase (EC 6.3.4.4) Cj1498c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968924|emb|CAB73920.1| (AL139078) adenylosuccinate
synthetase [Campylobacter jejuni]
Length = 416
Score = 215 bits (541), Expect = 8e-55
Identities = 134/415 (32%), Positives = 196/415 (46%), Gaps = 88/415 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
I+VG QWGDEGKG ++ L + + + R G NAGH++++NG +YA+ +P+G +
Sbjct: 6 IIVGIQWGDEGKGKVVDKLC--ENYDFVCRSAGGHNAGHTIWVNGVRYALHLMPSGVLHP 63
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYLHGK- 123
+ ++G GV+V PEV E+ + N+K R+ I R + + H +D L GK
Sbjct: 64 RCINIIGNGVVVSPEVLIAEMAQFE--NLKGRLYISDRAHLNLKHHSLIDIAKEKLKGKN 121
Query: 124 -IGTTGSGCGPANADRVMRKAKQAKDIKE------------------------------- 151
IGTTG G GP+ AD++ R + ++ E
Sbjct: 122 AIGTTGKGIGPSYADKINRTGHRVGELLEPQRLCEALIKDFEANKTFFEMLEIEIPSAEE 181
Query: 152 -----------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTA 200
L PY+TD + ALDE VL+EG QG L + +GTYPYVTS +
Sbjct: 182 LLADLKRFNEILTPYITDTTRMLWKALDEDKRVLLEGAQGSMLDIDHGTYPYVTSSSTIS 241
Query: 201 SSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGRRR 258
+ +G+ P ++I + K++ TRVG G FPTE E+ +++ + E G TGR+R
Sbjct: 242 AGTLTGLGLNPKEAGNIIGIVKAYATRVGNGAFPTEDKGEDGEKIAQIGKEIGVSTGRKR 301
Query: 259 RVGWFDFEMARYSARVNGATMLAITMLDKYD----------------------------- 289
R GWFD RY+AR+NG L++ LD D
Sbjct: 302 RCGWFDAVAVRYTARLNGLDALSLMKLDVLDGFEKIKICRAYEYKGMEIDYIPSDLENVQ 361
Query: 290 ---------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDL 335
+ FG+ DYD LP AK++I +EE GV V I T PE + I L
Sbjct: 362 PIYEEMDGWDKVFGIKDYDLLPENAKKYIARLEELAGVKVKYISTSPERDDTIIL 416
>sp|O68581|PURA_FUSNU ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|2961229|gb|AAC05693.1| (AF051374)
adenylosuccinate synthetase [Fusobacterium nucleatum]
Length = 425
Score = 214 bits (539), Expect = 1e-54
Identities = 133/427 (31%), Positives = 201/427 (46%), Gaps = 93/427 (21%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M +VVG QWGDEGKG II L+ ++ + + R G NAGH+V +NG+K+ ++ LP+G
Sbjct: 1 MAGYVVVGTQWGDEGKGKIIDVLS--EKADYVVRFQGGNNAGHTVVVNGEKFILQLLPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDRTNGY 119
+Q ++G GV+VDP+VF E++ +++ K D V I R +I H E+D+
Sbjct: 59 VLQA-GTCVIGPGVVVDPKVFLDEIDRIEKRGAKTDHVIISDRAHVIMPYHIEMDKIRES 117
Query: 120 LHG--KIGTTGSGCGPANADRVMRKAKQAKDIKELEPY---------------------- 155
+ KIGTT G GP AD++ R + D+ +L+ +
Sbjct: 118 VEDRIKIGTTKKGIGPCYADKIARDGIRMSDLLDLKQFEEKLRANLKEKNEIFTKIYGLE 177
Query: 156 ---------------------LTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
+ D +N ALDE LVL EG Q L + YGTYPYVT
Sbjct: 178 PLDFDKIFEEYKGYIEKIKHRIVDTIPIVNKALDENKLVLFEGAQAMMLDINYGTYPYVT 237
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGT 252
S T V G+ P +++ I V K++ TRVG GPF TE+ E D++ + EYG
Sbjct: 238 SSSPTLGGVTTGAGVSPRKINKGIGVMKAYTTRVGEGPFVTEIKGEFGDKIKGIGGEYGA 297
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITM---------------------------- 284
VTGR RR GW D + RY+ +NG T + IT
Sbjct: 298 VTGRPRRCGWLDLVVGRYATEINGLTDIVITKIDVLSGLGKLKICTAYEIDGKVYDYVPA 357
Query: 285 --------------LDKYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
LD +D++ + Y+ LP ++++E ++E + P+ ++ GP+
Sbjct: 358 DTKSLDKAIPIYEELDGWDEDITQIKKYEDLPVNCRKYLERVQEILACPISVVSVGPDRS 417
Query: 331 HIIDLRE 337
I +RE
Sbjct: 418 QNIHIRE 424
>pir||A45027 adenylosuccinate synthase (EC 6.3.4.4) - fission yeast
(Schizosaccharomyces pombe)
Length = 434
Score = 213 bits (538), Expect = 2e-54
Identities = 140/416 (33%), Positives = 200/416 (47%), Gaps = 89/416 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ L D ++ AR G NAGH++ NG Y LP+G +
Sbjct: 18 VVLGSQWGDEGKGKLVDILC--DNVDVCARCQGGNNAGHTIVANGVTYDFHILPSGLVNP 75
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVK--DRVGIDYRCAIIEEKHKELDRTNGYLHG 122
K + L+G+GV+V FF ELE L++ +K DR+ I R ++ + H+ D N G
Sbjct: 76 KCQNLIGSGVVVYLPAFFSELEKLEQKGLKQRDRIFISDRAHLVFDYHQRADALNEAELG 135
Query: 123 K--IGTTGSGCGPANADRVMR--------------KAKQAKDIKELE------------- 153
K IGTTG G GPA + + R +A+ K++ +L+
Sbjct: 136 KQSIGTTGKGIGPAYSTKATRSGIRVHHLYHWAEFEARYRKNVADLQKRYGAFEYDVEAE 195
Query: 154 ------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTAS 201
P++ D A + +AL +LVEG L L +GTYP+VTS + T
Sbjct: 196 LIRYKELAQRLKPFVIDAVAFMYEALQSKKRILVEGANALMLDLDFGTYPFVTSSNTTVG 255
Query: 202 SVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGRRRR 259
V +G+ P R+ + I V K++ TRVGAGPFPTE E D L V E G TGR+RR
Sbjct: 256 GVCTGLGVPPQRIANSIGVVKAYTTRVGAGPFPTEQLNEIGDHLQSVGREVGVTTGRKRR 315
Query: 260 VGWFDFEMARYSARVNGATMLAITMLDKYDK-----------------EAF--------- 293
GW D + +YS +NG T L +T LD D E F
Sbjct: 316 CGWLDLVVVKYSTMINGYTSLNLTKLDILDALDEIKVAVAYIINGKRIETFPADLDSLEE 375
Query: 294 ----------------GVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
G+T +D++P AK++IE IE+ VGVP+ I GP + ++
Sbjct: 376 AEIVYETFPGWKVPTTGITHWDQMPENAKKYIEFIEKFVGVPITFIGVGPGRDEML 431
>sp|Q02787|PURA_SCHPO ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7490083|pir||T37670 adenylosuccinate
synthase (EC 6.3.4.4) - fission yeast
(Schizosaccharomyces pombe) >gi|1799518|dbj|BAA19144.1|
(AB000538) adenylsuccinate synthetase
[Schizosaccharomyces pombe] >gi|6138894|emb|CAB59683.1|
(AL132675) adenylosuccinate synthetase (EC 6.3.4.4)
[Schizosaccharomyces pombe]
Length = 434
Score = 213 bits (538), Expect = 2e-54
Identities = 140/416 (33%), Positives = 200/416 (47%), Gaps = 89/416 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ L D ++ AR G NAGH++ NG Y LP+G +
Sbjct: 18 VVLGSQWGDEGKGKLVDILC--DNVDVCARCQGGNNAGHTIVANGVTYDFHILPSGLVNP 75
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVK--DRVGIDYRCAIIEEKHKELDRTNGYLHG 122
K + L+G+GV+V FF ELE L++ +K DR+ I R ++ + H+ D N G
Sbjct: 76 KCQNLIGSGVVVYLPAFFSELEKLEQKGLKCRDRIFISDRAHLVFDYHQRADALNEAELG 135
Query: 123 K--IGTTGSGCGPANADRVMR--------------KAKQAKDIKELE------------- 153
K IGTTG G GPA + + R +A+ K++ +L+
Sbjct: 136 KQSIGTTGKGIGPAYSTKATRSGIRVHHLYHWAEFEARYRKNVADLQKRYGAFEYDVEAE 195
Query: 154 ------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTAS 201
P++ D A + +AL +LVEG L L +GTYP+VTS + T
Sbjct: 196 LIRYKELAQRLKPFVIDAVAFMYEALQSKKRILVEGANALMLDLDFGTYPFVTSSNTTVG 255
Query: 202 SVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGRRRR 259
V +G+ P R+ + I V K++ TRVGAGPFPTE E D L V E G TGR+RR
Sbjct: 256 GVCTGLGVPPQRIANSIGVVKAYTTRVGAGPFPTEQLNEIGDHLQSVGREVGVTTGRKRR 315
Query: 260 VGWFDFEMARYSARVNGATMLAITMLDKYDK-----------------EAF--------- 293
GW D + +YS +NG T L +T LD D E F
Sbjct: 316 CGWLDLVVVKYSTMINGYTSLNLTKLDILDALDEIKVAVAYIINGKRIETFPADLDSLEE 375
Query: 294 ----------------GVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
G+T +D++P AK++IE IE+ VGVP+ I GP + ++
Sbjct: 376 AEIVYETFPGWKVPTTGITHWDQMPENAKKYIEFIEKFVGVPITFIGVGPGRDEML 431
>gb|AAA70333.1| (M98805) adenylosuccinate synthetase [Schizosaccharomyces pombe]
Length = 434
Score = 212 bits (534), Expect = 5e-54
Identities = 140/416 (33%), Positives = 198/416 (46%), Gaps = 89/416 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ L D ++ AR G NAGH++ NG Y LP+G +
Sbjct: 18 VVLGSQWGDEGKGKLVDILC--DNVDVCARCQGGNNAGHTIVANGVTYDFHILPSGLVNP 75
Query: 65 KARLLVGAGVLVDPEVFFHELEHL--KEFNVKDRVGIDYRCAIIEEKHKELDRTNGYLHG 122
K + L+G+GV+V FF ELE L K +DR+ I R ++ + H+ D N G
Sbjct: 76 KCQNLIGSGVVVYLPAFFSELEKLVQKGLKCRDRLFISDRAHLVFDYHQRADALNEAELG 135
Query: 123 K--IGTTGSGCGPANADRVMR--------------KAKQAKDIKELE------------- 153
K IGTTG G GPA + + R +A+ K++ +L+
Sbjct: 136 KQSIGTTGKGIGPAYSTKATRSGIRVHHLYHWAEFEARYRKNVADLQKRYGAFEYDVEAE 195
Query: 154 ------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTAS 201
P++ D A + +AL +LVEG L L +GTYP+VTS + T
Sbjct: 196 LIRYKELAQRLKPFVIDAVAFMYEALQSKKRILVEGANALMLDLDFGTYPFVTSSNTTVG 255
Query: 202 SVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGRRRR 259
V +G+ P R+ + I V K++ TRVGAGPFPTE E D L V E G TGR+RR
Sbjct: 256 GVCTGLGVPPQRIANSIGVVKAYTTRVGAGPFPTEQLNEIGDHLQSVGREVGVTTGRKRR 315
Query: 260 VGWFDFEMARYSARVNGATMLAITMLDKYDK-----------------EAF--------- 293
GW D + +YS +NG T L +T LD D E F
Sbjct: 316 CGWLDLVVVKYSTMINGYTSLNLTKLDILDALDEIKVAVAYIINGKRIETFPADLDSLEE 375
Query: 294 ----------------GVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
G+T +D++P AK++IE IE+ VGVP+ I GP + ++
Sbjct: 376 AEIVYETFPGWKVPTTGITHWDQMPENAKKYIEFIEKFVGVPITFIGVGPGRDEML 431
>sp|Q9X8P6|PURA_STRCO ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7480426|pir||T36519 probable
adenylosuccinate synthetase - Streptomyces coelicolor
>gi|4753853|emb|CAB42016.1| (AL049754) putative
adenylosuccinate synthetase [Streptomyces coelicolor
A3(2)]
Length = 427
Score = 211 bits (532), Expect = 9e-54
Identities = 137/425 (32%), Positives = 197/425 (46%), Gaps = 92/425 (21%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
MP+L+++G QWGDEGKG L + + R G NAGH+V + +KYA+ LP+G
Sbjct: 1 MPALVLLGAQWGDEGKGKATDLLG--GSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDRTNGY 119
+ ++G GV+VDP V F EL L E V ++ I II + +D+
Sbjct: 59 ILSPGCTPVIGNGVVVDPSVLFSELSGLNERGVDTSKLLISGNAHIITPYNVTVDKVTER 118
Query: 120 LHGK--IGTTGSGCGPANADRVMR----------------KAKQAKDIK----------- 150
GK IGTTG G GP AD++ R K + A D+K
Sbjct: 119 FLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILTQKVEAALDVKNQMLTKLYNRR 178
Query: 151 ----------------ELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
+L PY+ D +N ALD+ +VL EG QG L + +GTYP+VT
Sbjct: 179 AIATGQVVEELLGYADKLAPYVADTVLVLNQALDDDKVVLFEGGQGTLLDIDHGTYPFVT 238
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGT 252
S + TA G+GPT++ VI + K++ TRVGAGPFPTE+ E+ + L + E G
Sbjct: 239 SSNPTAGGACTGAGVGPTKISRVIGILKAYTTRVGAGPFPTELFDEDGEALRRIGGERGV 298
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLD-------------------------- 286
TGR RR GWFD +ARY+ RVNG T +T LD
Sbjct: 299 TTGRDRRCGWFDAVIARYATRVNGLTDFFLTKLDVLTGWEQIPVCVAYEIDGKRVEELPY 358
Query: 287 ----------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ ++ + LP+ A+ +++ +EE G P+ I GP +
Sbjct: 359 SQSDFHHAKPVYETLPGWSEDITKAKSFSDLPKNAQAYVKALEEMSGAPISAIGVGPGRD 418
Query: 331 HIIDL 335
I++
Sbjct: 419 ETIEI 423
>pir||B82803 adenylosuccinate synthetase XF0455 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9105301|gb|AAF83265.1|AE003896_2
(AE003896) adenylosuccinate synthetase [Xylella
fastidiosa]
Length = 440
Score = 208 bits (525), Expect = 6e-53
Identities = 135/426 (31%), Positives = 196/426 (45%), Gaps = 93/426 (21%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
S++V+G QWGDEGKG I+ L +E + R G NAGH++ INGKK + +P+G +
Sbjct: 14 SVVVLGAQWGDEGKGKIVDLLT--EEIGAVVRFQGGHNAGHTLVINGKKTVLHLIPSGIL 71
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ L+G GV++ P E+E L++ ++ R+ I +I E H LD+
Sbjct: 72 RNGVLCLIGNGVVISPAALRKEIEELEDTGLEIRSRLKISPAAPLIMEYHIALDQAREKA 131
Query: 121 HG--KIGTTGSGCGPANADRVMRKAKQAKDI----------------------------- 149
G IGTTG G GPA D+V R+ + D+
Sbjct: 132 AGGRAIGTTGRGIGPAYEDKVGRRGIRVADLHYPDQLAEKLRDALDYHNFVLTRYFGVDG 191
Query: 150 --------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTS 195
+ +EP +DVA ++D +G VL EG QG L + +GTYPYVTS
Sbjct: 192 MDFQRIYDEMLVFAEYVEPMKSDVAGILHDLRKQGKRVLFEGAQGTLLDIDHGTYPYVTS 251
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME--EADRLGLVEYGTV 253
T + G+G +D V+ + K++ TRVG GPFPTE+ E + R VEYG
Sbjct: 252 SSTTVGGALSGAGVGVQDIDYVLGIAKAYATRVGGGPFPTELDDEIGQGIRDRGVEYGAS 311
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGR RR GW D + + +NG T L IT LD D
Sbjct: 312 TGRPRRCGWMDIVALKRAVAINGITGLCITKLDVLDGMDKLKICIAYEYHDKRSEYAPLD 371
Query: 290 ------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEH 331
+ G+T ++KLP A+ ++ +EE G P+G++ TGP+ EH
Sbjct: 372 AQGWEECTPVYLEFPGWNESTHGITSWEKLPPAARAYLCALEELAGCPIGIVSTGPDREH 431
Query: 332 IIDLRE 337
I L +
Sbjct: 432 TIMLHD 437
>pir||C75567 adenylosuccinate synthase - Deinococcus radiodurans (strain R1)
>gi|6457695|gb|AAF09627.1|AE001867_2 (AE001867)
adenylosuccinate synthase [Deinococcus radiodurans]
Length = 405
Score = 208 bits (525), Expect = 6e-53
Identities = 137/403 (33%), Positives = 189/403 (45%), Gaps = 80/403 (19%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
MP + +VG QWGDEGKG I+ +LA E E + R G NAGH+V GK + + LP+G
Sbjct: 1 MPGIAIVGAQWGDEGKGKIVDFLA--PEAEYVVRYQGGANAGHTVNAKGKTFKLNLLPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ A ++G G+++DPE F E +L E + R+ I R I+ HK +D +
Sbjct: 59 VLHEGATSILGDGMVIDPEKFIEERRNLMEGGLNPRLKISDRAHIVLPHHKYVDGRKDF- 117
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDI------------------------------- 149
+GTTG G GPA ADR R + D+
Sbjct: 118 ---VGTTGKGIGPAYADRARRVGIRFGDLLDEGVLRERIERLLEAKPNSTRDAGWATVED 174
Query: 150 ---------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTA 200
++L P++ D +E+ A+ +G VL EG Q L L YGTYP+VTS T
Sbjct: 175 GLKSLAPIREQLAPFIADTGSELRQAIKDGRKVLFEGAQATLLDLNYGTYPFVTSSHPTV 234
Query: 201 SSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--------VEYGT 252
+ G+ + V V K+F TRVG GPF TE+ +EA L L EYGT
Sbjct: 235 GGILVGTGVNHKALHRVYGVAKAFNTRVGHGPFATEV-HDEAGILRLRGDGSQPWDEYGT 293
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLD------------KYDK---------- 290
TGR RRVGW D E+ +Y+ VNG L I +D YD+
Sbjct: 294 TTGRPRRVGWLDLELLKYAVDVNGLDGLVINKMDILGGLDEIPVCTGYDEGGQPVFKKMK 353
Query: 291 ---EAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
GVT LP++A+ +++ IE+ V PV + GPE E
Sbjct: 354 GWSSTDGVTSRATLPKEAQAYLDLIEDTVQCPVVIFSAGPERE 396
>sp|P12283|PURA_ECOLI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|2144565|pir||AJECDS adenylosuccinate
synthase (EC 6.3.4.4) purA [validated] - Escherichia
coli >gi|537018|gb|AAA97073.1| (U14003) adenylosuccinate
synthetase [Escherichia coli] >gi|1790620|gb|AAC77134.1|
(AE000490) adenylosuccinate synthetase [Escherichia coli
K12]
Length = 432
Score = 206 bits (520), Expect = 2e-52
Identities = 133/427 (31%), Positives = 200/427 (46%), Gaps = 94/427 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L + + + R G NAGH++ ING+K + +P+G +
Sbjct: 4 NVVVLGTQWGDEGKGKIVDLLT--ERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++G GV++ P E++ L++ V++R+ + C +I + H LD
Sbjct: 62 RENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKA 121
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
G IGTTG G GPA D+V R+ + D+ + E +
Sbjct: 122 RGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEA 181
Query: 156 ----------------LTDVAAEINDALDE----GALVLVEGTQGFGLSLYYGTYPYVTS 195
LT + +++D LD+ G V+ EG QG L + +GTYPYVTS
Sbjct: 182 VDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+ TA VA G+GP VD V+ + K++ TRVGAGPFPTE+ E + L E+G
Sbjct: 242 SNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGAT 301
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGRRRR GW D R + ++N + +T LD D
Sbjct: 302 TGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPL 361
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ FGV D LP+ A +I+ IEE GVP+ +I TGP+
Sbjct: 362 AADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRT 421
Query: 331 HIIDLRE 337
+ LR+
Sbjct: 422 ETMILRD 428
>pdb|1ADE|A Chain A, Structure Of Adenylosuccinate Synthetase Ph7 At 25 Degrees
Celsius >gi|1310914|pdb|1ADE|B Chain B, Structure Of
Adenylosuccinate Synthetase Ph7 At 25 Degrees Celsius
>gi|6730454|pdb|1QF5|A Chain A, Design, Synthesis, And
X-Ray Crystal Structure Of An Enzyme Bound Bisubstrate
Hybrid Inhibitor Of Adenylosuccinate Synthetase
>gi|6730453|pdb|1QF4|A Chain A, Design, Synthesis, And
X-Ray Crystal Structure Of An Enzyme Bound Bisubstrate
Hybrid Inhibitor Of Adenylosuccinate Synthetase
>gi|1942273|pdb|1HOO|A Chain A, Structure Of Guanine
Nucleotide (Gppcp) Complex Of Adenylosuccinate
Synthetase From E. Coli At Ph6.5 And 25 Degrees Celsius
>gi|1942274|pdb|1HOO|B Chain B, Structure Of Guanine
Nucleotide (Gppcp) Complex Of Adenylosuccinate
Synthetase From E. Coli At Ph6.5 And 25 Degrees Celsius
>gi|1943505|pdb|1HOP|A Chain A, Structure Of Guanine
Nucleotide (Gppcp) Complex Of Adenylosuccinate
Synthetase From Escherichia Coli At Ph6.5 And 25 Degrees
Celsius >gi|1943506|pdb|1HOP|B Chain B, Structure Of
Guanine Nucleotide (Gppcp) Complex Of Adenylosuccinate
Synthetase From Escherichia Coli At Ph6.5 And 25 Degrees
Celsius >gi|1943503|pdb|1HON|A Chain A, Structure Of
Guanine Nucleotide (Gppcp) Complex Of Adenylosuccinate
Synthetase From Escherichia Coli At Ph6.5 And 25 Degree
Celsius >gi|1943504|pdb|1HON|B Chain B, Structure Of
Guanine Nucleotide (Gppcp) Complex Of Adenylosuccinate
Synthetase From Escherichia Coli At Ph6.5 And 25 Degree
Celsius >gi|7546190|pdb|1CIB|A Chain A, Structure Of
Adenylosuccinate Synthetase From E. Coli Complexed With
Gdp, Imp, Hadacidin, And No3 >gi|1633545|pdb|1ADI|A
Chain A, Structure Of Adenylosuccinate Synthetase At
Ph6.5 And 25 Degrees Celsius >gi|1633546|pdb|1ADI|B
Chain B, Structure Of Adenylosuccinate Synthetase At
Ph6.5 And 25 Degrees Celsius >gi|6730168|pdb|1CH8|A
Chain A, Structure Of Adenylosuccinate Synthetase From
E. Coli Complexed With A Stringent Effector, Ppg2':3'p
>gi|1942847|pdb|1GIM| Crystal Structure Of
Adenylosuccinate Synthetase From Escherichia Coli
Complexed With Gdp, Imp, Hadacidin, No3-, And Mg2+. Data
Collected At 100k (Ph6.5) >gi|5542172|pdb|1CG0|A Chain
A, Structure Of Adenylosuccinate Synthetase From E. Coli
Complexed With Hadacidin, Gdp, 6-Phosphoryl-Imp, And
Mg2+ >gi|2624892|pdb|1NHT| Entrapment Of
6-Thiophosphoryl-Imp In The Active Site Of Crystalline
Adenylosuccinate Synthetase From Escherichia Coli Data
Collected At 100k >gi|2554686|pdb|1SON|
Adenylosuccinate Synthetase In Complex With The Natural
Feedback Inhibitor Amp >gi|2554687|pdb|1SOO|
Adenylosuccinate Synthetase Inhibited By Hydantocidin
5'-Monophosphate >gi|2392403|pdb|1JUY| Refined Crystal
Structure Of Adenylosuccinate Synthetase From
Escherichia Coli Complexed With Hydantocidin
5'-Phosphate Gdp, Hpo4(2-), Mg2+, And Hadacidin
>gi|1942394|pdb|1GIN| Crystal Structure Of
Adenylosuccinate Synthetase From Escherichia Coli
Complexed With Gdp, Imp, Hadacidin, No3-, And Mg2+.
Data Collected At 298k (Ph6.5). >gi|2624891|pdb|1KSZ|
Entrapment Of 6-Thiophosphoryl-Imp In The Active Site Of
Crystalline Adenylosuccinate Synthetase From Escherichia
Coli, Data Collected At 298k
Length = 431
Score = 206 bits (520), Expect = 2e-52
Identities = 133/427 (31%), Positives = 200/427 (46%), Gaps = 94/427 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L + + + R G NAGH++ ING+K + +P+G +
Sbjct: 3 NVVVLGTQWGDEGKGKIVDLLT--ERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGIL 60
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++G GV++ P E++ L++ V++R+ + C +I + H LD
Sbjct: 61 RENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKA 120
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
G IGTTG G GPA D+V R+ + D+ + E +
Sbjct: 121 RGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEA 180
Query: 156 ----------------LTDVAAEINDALDE----GALVLVEGTQGFGLSLYYGTYPYVTS 195
LT + +++D LD+ G V+ EG QG L + +GTYPYVTS
Sbjct: 181 VDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTS 240
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+ TA VA G+GP VD V+ + K++ TRVGAGPFPTE+ E + L E+G
Sbjct: 241 SNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGAT 300
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGRRRR GW D R + ++N + +T LD D
Sbjct: 301 TGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPL 360
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ FGV D LP+ A +I+ IEE GVP+ +I TGP+
Sbjct: 361 AADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRT 420
Query: 331 HIIDLRE 337
+ LR+
Sbjct: 421 ETMILRD 427
>dbj|BAA89445.1| (AB003160) adenylosuccinate synthetase [Corynebacterium
ammoniagenes]
Length = 430
Score = 206 bits (520), Expect = 2e-52
Identities = 136/423 (32%), Positives = 199/423 (46%), Gaps = 92/423 (21%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M ++++VG QWGDEGKG L + + + G NAGH+V + G+KY ++ LP G
Sbjct: 1 MAAIVIVGAQWGDEGKGKATDILG--GRVDYVVKPNGGNNAGHTVVVGGEKYELKLLPAG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDRTNGY 119
+ A ++G GV+++ E F E+E L+ R+ I ++ H+ LDR
Sbjct: 59 ILSENAVPVLGNGVVINLEALFEEIEGLEARGADASRLRISANAHLVAPYHQTLDRVQER 118
Query: 120 LHGK--IGTTGSGCGPANADRVMR----------------KAKQAKDIKE---------- 151
GK IGTTG G GPA AD+V R K + A DIK
Sbjct: 119 FLGKRAIGTTGRGIGPAYADKVARVGVRVQDIFDESILRQKVESALDIKNQMLVKMYNRK 178
Query: 152 -----------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
LEP + D E+N ALD G VL+EG Q L + +GTYP+VT
Sbjct: 179 AIDPETIVEYFLSYRDRLEPMVVDSEYELNTALDAGKHVLMEGGQATMLDVDHGTYPFVT 238
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGT 252
S + TA + G+GPTR+ + + K++ TRVGAGPFPTE+ + + L E G
Sbjct: 239 SSNPTAGGASVGSGVGPTRITHSLGIIKAYTTRVGAGPFPTELFDKWGEYLQTTGGEVGV 298
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLD-------------------------- 286
TGR RR GW+D +ARY++RVNG T +T LD
Sbjct: 299 NTGRTRRCGWYDSVIARYASRVNGFTDYFLTKLDVLTGIGEIPICVAYDVDGERFDEMPL 358
Query: 287 ----------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
++++ G T +++LP+KA++++ +EE G + I GP +
Sbjct: 359 TQSQFHHAQPIYETMPAWEEDITGCTTFEELPQKAQDYVLRLEELSGTRMSYIGVGPGRD 418
Query: 331 HII 333
I
Sbjct: 419 QTI 421
>pir||F82055 adenylosuccinate synthetase VC2602 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657190|gb|AAF95743.1|
(AE004327) adenylosuccinate synthetase [Vibrio cholerae]
Length = 432
Score = 206 bits (519), Expect = 3e-52
Identities = 131/423 (30%), Positives = 198/423 (45%), Gaps = 94/423 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L ++ + + R G NAGH++ I+G+K + +P+G +
Sbjct: 4 NVVVLGTQWGDEGKGKIVDLLT--EDAKYVVRYQGGHNAGHTLVIDGQKTVLHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEFNV--KDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ + ++G GV++ PE E+ L++ V ++R+ I C +I H LD+
Sbjct: 62 RNNVKCIIGNGVVLSPEALIKEMSGLEDRGVPVRERLFISEACPLILPYHVALDQAREAA 121
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
GK IGTTG G GPA D+V R+ + D+ ++ +
Sbjct: 122 RGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFDMASFAEKLQEVMAFHNFQLEHFYKVEP 181
Query: 156 --------------------LTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTS 195
+ DV E++ A G ++ EG QG L + +GTYPYVTS
Sbjct: 182 VSYEAVLEQAKGYAELLTSMVIDVTNELDAARKRGDKIMFEGAQGTLLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+ TA VAA G GP + ++ + K++ TRVGAGPFPTE+ E D LG E+G
Sbjct: 242 SNTTAGGVAAGSGFGPRHLGYILGIAKAYCTRVGAGPFPTELFDEVGDHLGTKGHEFGAT 301
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGR+RR GWFD R + ++N T +T LD D
Sbjct: 302 TGRKRRCGWFDAVAMRRAIQINSVTGFCLTKLDVLDGLKEIKICTGYQMPDGSIAEVSPM 361
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ FG +LP+ A ++I+ IEE GVPV +I TGP+
Sbjct: 362 AADAFENVTPIFETMPGWSETTFGAKTLAELPQTALDYIKRIEELTGVPVDIISTGPDRN 421
Query: 331 HII 333
I
Sbjct: 422 ETI 424
>sp|P40607|PURA_VIBPA ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|507736|gb|AAA62188.1| (U09005) PurA
[Vibrio parahaemolyticus]
Length = 438
Score = 205 bits (517), Expect = 5e-52
Identities = 134/429 (31%), Positives = 202/429 (46%), Gaps = 100/429 (23%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L ++ + + R G NAGH++ I+G+K + +P+G +
Sbjct: 4 NVVVLGTQWGDEGKGKIVDLLT--EDAKYVVRYQGGHNAGHTLVIDGEKTVLHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ + ++G GV++ PE E++ L+E V++R+ I C +I H +D+
Sbjct: 62 RDNVKCVIGNGVVLSPEALLKEMKPLEERGIPVRERLFISEACPLILPYHVAMDQAREIA 121
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
GK IGTTG G GPA D+V R+ + D+ ++E +
Sbjct: 122 RGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFDMEAFAEKLKEVMEYHNFQLVNFYKAEP 181
Query: 156 ----------------LTDVAAEINDALD----EGALVLVEGTQGFGLSLYYGTYPYVTS 195
LT + ++ D LD G ++ EG QG L + +GTYPYVTS
Sbjct: 182 VSYEAVLEEAKGYAELLTSMVIDVTDELDAARKRGDKIMFEGAQGTLLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEM--PMEEAD----RLGLV- 248
+ TA VAA G GP + ++ + K++ TRVGAGPFPTE+ +E+ D LG V
Sbjct: 242 SNTTAGGVAAGSGFGPRHIGYILGIAKAYCTRVGAGPFPTELYDGLEKQDPVGKHLGTVG 301
Query: 249 -EYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------ 289
E+G TGR RR GWFD R + ++N + +T LD D
Sbjct: 302 HEFGATTGRLRRTGWFDAVAMRRAIQINSVSGFCLTKLDVLDGLEELKICTGYKMEDGSV 361
Query: 290 -------------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIK 324
+ FG D LP+ A +I+ IEE GVPV +I
Sbjct: 362 LEVSPMAAEAFEKATPIYETMPGWSENTFGAKSLDALPQAALNYIKRIEELTGVPVDIIS 421
Query: 325 TGPELEHII 333
TGP+ I
Sbjct: 422 TGPDRNETI 430
>pdb|1CG1|A Chain A, Structure Of The Mutant (K16q) Of Adenylosuccinate
Synthetase From E. Coli Complexed With Hadacidin, Gdp,
6- Phosphoryl-Imp, And Mg2+
Length = 431
Score = 205 bits (516), Expect = 7e-52
Identities = 132/427 (30%), Positives = 200/427 (45%), Gaps = 94/427 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEG+G I+ L + + + R G NAGH++ ING+K + +P+G +
Sbjct: 3 NVVVLGTQWGDEGQGKIVDLLT--ERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGIL 60
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++G GV++ P E++ L++ V++R+ + C +I + H LD
Sbjct: 61 RENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKA 120
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
G IGTTG G GPA D+V R+ + D+ + E +
Sbjct: 121 RGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEA 180
Query: 156 ----------------LTDVAAEINDALDE----GALVLVEGTQGFGLSLYYGTYPYVTS 195
LT + +++D LD+ G V+ EG QG L + +GTYPYVTS
Sbjct: 181 VDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTS 240
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+ TA VA G+GP VD V+ + K++ TRVGAGPFPTE+ E + L E+G
Sbjct: 241 SNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGAT 300
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGRRRR GW D R + ++N + +T LD D
Sbjct: 301 TGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPL 360
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ FGV D LP+ A +I+ IEE GVP+ +I TGP+
Sbjct: 361 AADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRT 420
Query: 331 HIIDLRE 337
+ LR+
Sbjct: 421 ETMILRD 427
>sp|P21900|PURA_DICDI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|68634|pir||AJDODS adenylosuccinate
synthase (EC 6.3.4.4) - slime mold (Dictyostelium
discoideum) >gi|167668|gb|AAA33167.1| (M58471)
adenylosuccinate synthetase [Dictyostelium discoideum]
Length = 427
Score = 205 bits (515), Expect = 9e-52
Identities = 132/426 (30%), Positives = 203/426 (46%), Gaps = 93/426 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
I++G QWGDEGKG ++ L+ + +++AR G NAGH++ ++GKK A+ +P+G +
Sbjct: 4 IIIGSQWGDEGKGKLVDILS--QQFDVVARCQGGANAGHTIVVDGKKIALHLIPSGILNE 61
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKH------KELDRT 116
KA ++G G+++ FF E++ L++ N K R+ + R ++ + H KE + +
Sbjct: 62 KASCILGNGMVIHLPTFFKEVQGLQDKGINYKGRLFVSDRAHLVFDLHQMIDAMKEAELS 121
Query: 117 NGYLHGKIGTTGSGCGPANADRVMRKAKQAKDI--------------------------- 149
NG + IGTT G GP + + R + D+
Sbjct: 122 NGTSNDSIGTTKRGIGPCYSSKASRGGLRVCDLYSPEHFRKTFTRLVENKHKRFGSFEYD 181
Query: 150 ------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKD 197
+ L+P++ D +N A +G VL+EG Q L L +G YPYVTS
Sbjct: 182 VEAELKRYQEFAEMLKPFVIDSVYYLNQAFKDGKKVLIEGAQSTMLDLDFGCYPYVTSSA 241
Query: 198 VTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTG 255
+ +GI P +V I V K++ T+VG+GPFPTE D L E+GT TG
Sbjct: 242 SSVGGACTGLGISPNKVVTQIGVVKAYTTKVGSGPFPTEQNDHVGDSLRKAGSEFGTTTG 301
Query: 256 RRRRVGWFDFEMARYSARVNGATMLAITMLD--------------KYDKEAF-------- 293
R RR+GW D + RY++ +N T L +T LD KY E
Sbjct: 302 RPRRIGWLDAVVLRYTSMINDFTRLNLTKLDVLSDFEEIKIGVDYKYKGETIKSFPASLE 361
Query: 294 --------------------GVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
VT+YD+LP +AK +I+ IEE VGVP+ I G E +++I
Sbjct: 362 TLAQCEVVYESFPGWKCDLSHVTEYDQLPIQAKNYIKRIEELVGVPIVYIGVGVERKNLI 421
Query: 334 DLRENI 339
+ +E I
Sbjct: 422 ERKELI 427
>pdb|1CG4|A Chain A, Structure Of The Mutant (R303l) Of Adenylosuccinate
Synthetase From E. Coli Complexed With, Gdp,
6-Phosphoryl- Imp, And Mg2+
Length = 431
Score = 204 bits (513), Expect = 1e-51
Identities = 132/427 (30%), Positives = 199/427 (45%), Gaps = 94/427 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L + + + R G NAGH++ ING+K + +P+G +
Sbjct: 3 NVVVLGTQWGDEGKGKIVDLLT--ERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGIL 60
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++G GV++ P E++ L++ V++R+ + C +I + H LD
Sbjct: 61 RENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKA 120
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
G IGTTG G GPA D+V R+ + D+ + E +
Sbjct: 121 RGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEA 180
Query: 156 ----------------LTDVAAEINDALDE----GALVLVEGTQGFGLSLYYGTYPYVTS 195
LT + +++D LD+ G V+ EG QG L + +GTYPYVTS
Sbjct: 181 VDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTS 240
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+ TA VA G+GP VD V+ + K++ TRVGAGPFPTE+ E + L E+G
Sbjct: 241 SNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGAT 300
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TG RRR GW D R + ++N + +T LD D
Sbjct: 301 TGLRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPL 360
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ FGV D LP+ A +I+ IEE GVP+ +I TGP+
Sbjct: 361 AADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRT 420
Query: 331 HIIDLRE 337
+ LR+
Sbjct: 421 ETMILRD 427
>gb|AAA24446.1| (J04199) adenylosuccinate synthetase (EC 6.3.4.4) [Escherichia
coli]
Length = 432
Score = 204 bits (513), Expect = 1e-51
Identities = 132/427 (30%), Positives = 199/427 (45%), Gaps = 94/427 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L + + + R G NAGH++ ING+K + +P+G +
Sbjct: 4 NVVVLGTQWGDEGKGKIVDLLT--ERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++G GV++ P E++ L++ V++R+ + C +I + H LD
Sbjct: 62 RENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKA 121
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
G IGTTG G GPA D+V R+ + D+ + E +
Sbjct: 122 RGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEA 181
Query: 156 ----------------LTDVAAEINDALDE----GALVLVEGTQGFGLSLYYGTYPYVTS 195
LT + +++D LD+ G V+ EG QG L + +GTYPYVTS
Sbjct: 182 VDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+ TA VA G+GP VD V+ + K++ TRVGAGPFPTE+ E + L E+G
Sbjct: 242 SNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGAT 301
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGRRRR GW D R + ++N + +T LD D
Sbjct: 302 TGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPL 361
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ FGV D LP+ A +I+ IEE GVP+ +I T P+
Sbjct: 362 AADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTDPDRT 421
Query: 331 HIIDLRE 337
+ LR+
Sbjct: 422 ETMILRD 428
>pdb|1CG3|A Chain A, Structure Of The Mutant (R143l) Of Adenylosuccinate
Synthetase From E. Coli Complexed With Hadacidin, Gdp,
6- Phosphoryl-Imp, And Mg2+
Length = 431
Score = 204 bits (513), Expect = 1e-51
Identities = 132/427 (30%), Positives = 199/427 (45%), Gaps = 94/427 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L + + + R G NAGH++ ING+K + +P+G +
Sbjct: 3 NVVVLGTQWGDEGKGKIVDLLT--ERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGIL 60
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++G GV++ P E++ L++ V++R+ + C +I + H LD
Sbjct: 61 RENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKA 120
Query: 121 HGK--IGTTGSGCGPANADRVMRKAKQAKDIKELEPY----------------------- 155
G IGTTG G GPA D+V + + D+ + E +
Sbjct: 121 RGAKAIGTTGRGIGPAYEDKVALRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEA 180
Query: 156 ----------------LTDVAAEINDALDE----GALVLVEGTQGFGLSLYYGTYPYVTS 195
LT + +++D LD+ G V+ EG QG L + +GTYPYVTS
Sbjct: 181 VDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTS 240
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+ TA VA G+GP VD V+ + K++ TRVGAGPFPTE+ E + L E+G
Sbjct: 241 SNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGAT 300
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGRRRR GW D R + ++N + +T LD D
Sbjct: 301 TGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPL 360
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
+ FGV D LP+ A +I+ IEE GVP+ +I TGP+
Sbjct: 361 AADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRT 420
Query: 331 HIIDLRE 337
+ LR+
Sbjct: 421 ETMILRD 427
>sp|P45283|PURA_HAEIN ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|1073821|pir||G64133 adenylosuccinate
synthase (EC 6.3.4.4) - Haemophilus influenzae (strain
Rd KW20) >gi|1574479|gb|AAC23278.1| (U32836)
adenylosuccinate synthetase (purA) [Haemophilus
influenzae Rd]
Length = 432
Score = 203 bits (510), Expect = 3e-51
Identities = 137/428 (32%), Positives = 195/428 (45%), Gaps = 96/428 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
S++++G QWGDEGKG I+ L D + + R G NAGH++ ING+K +R +P+G +
Sbjct: 4 SVVILGAQWGDEGKGKIVDLLT--DRVKYVVRYQGGHNAGHTLIINGEKTVLRLIPSGML 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
L+G GV+V PE E+ L+ V++R+ I C +I H +D
Sbjct: 62 HPNVTCLIGNGVVVSPEALMKEMGELESRGIKVRERLLISEACPLILPYHVAMDHAREAA 121
Query: 121 HGK--IGTTGSGCGPANADRVMRKA----------------------------------- 143
GK IGTTG G GPA D+V R+
Sbjct: 122 LGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFNKEAFAEKLKNILEYYNFQLVNYYKVEP 181
Query: 144 ----KQAKDIKELEPYLTDVAAEINDALD----EGALVLVEGTQGFGLSLYYGTYPYVTS 195
K D+ + +T + A+I LD G +L EG QG L + +GTYPYVTS
Sbjct: 182 VDYQKTLDDVMAIADVITGMVADITTILDTARKNGEHILFEGAQGTMLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPME---EADRLGLVEYGT 252
+ TA VA G GP +D V+ + K++ TRVG GPF TE+ + E R G E+G
Sbjct: 242 SNTTAGGVATGSGFGPRNLDYVLGIIKAYCTRVGGGPFTTELFDDVGAEIARKG-NEFGA 300
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD----------------------- 289
VTGR RR GWFD R + ++N + +T LD D
Sbjct: 301 VTGRPRRCGWFDAVAIRRAIQLNSISGFCMTKLDVLDGFDEVKICVAYKMPNGEIVEYAP 360
Query: 290 --------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPEL 329
+ F +TD +KLP+ +I+ IEE GVP+ ++ TGP+
Sbjct: 361 LAAKDWEGVEPIYETLPGWKENTFRITDVNKLPQNCINYIKRIEEVTGVPIDILSTGPDR 420
Query: 330 EHIIDLRE 337
+ LRE
Sbjct: 421 VETMILRE 428
>pir||F83027 adenylosuccinate synthetase PA4938 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951218|gb|AAG08323.1|AE004907_1 (AE004907)
adenylosuccinate synthetase [Pseudomonas aeruginosa]
Length = 430
Score = 202 bits (508), Expect = 6e-51
Identities = 132/425 (31%), Positives = 198/425 (46%), Gaps = 93/425 (21%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L ++ + R G NAGH++ I+G+K + +P+G +
Sbjct: 4 NVVVLGTQWGDEGKGKIVDLLT--EQAAAVVRYQGGHNAGHTLVIDGEKTVLHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEFNV--KDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ + L+G GV++ P+ E+ L+E V ++R+ I C +I H LD+
Sbjct: 62 REGVQCLIGNGVVLAPDALLREITKLEEKGVPVRERLRISPSCPLILSYHVALDQAREKA 121
Query: 121 HG--KIGTTGSGCGPANADRVMRKAKQAKDI-------------------------KE-- 151
G KIGTTG G GPA D+V R+ + D+ KE
Sbjct: 122 RGEAKIGTTGRGIGPAYEDKVARRGLRVGDLFHRERFAAKLGELLDYHNFVLQHYYKEPA 181
Query: 152 ----------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTS 195
L+P + DVAA ++D G ++ EG QG L + +GTYPYVTS
Sbjct: 182 IDFQKTLDEAMEYAELLKPMMADVAATLHDLRKHGKDIMFEGAQGSLLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGTV 253
+ TA A G GP +D V+ + K++ TRVG+GPFPTE+ + L E+G
Sbjct: 242 SNTTAGGTATGSGFGPLYLDYVLGITKAYTTRVGSGPFPTELFDDVGAYLAKRGHEFGAT 301
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGR RR GWFD + R + +N + L +T LD D
Sbjct: 302 TGRARRCGWFDAVILRRAIEINSISGLCLTKLDVLDGLDVVRLCVGYKNADGDVLEAPTD 361
Query: 290 ------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEH 331
+ G ++LP A+ +I+ +EE VG P+ +I TGP+
Sbjct: 362 ADSYIGLQPVYEEMPGWSESTVGAKTLEELPANARAYIKRVEELVGAPIDIISTGPDRNE 421
Query: 332 IIDLR 336
I LR
Sbjct: 422 TIILR 426
>sp|O08381|PURA_MYCTU ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7438023|pir||F70575 probable PurA -
Mycobacterium tuberculosis (strain H37RV)
>gi|2094838|emb|CAB08565.1| (Z95324) purA [Mycobacterium
tuberculosis]
Length = 432
Score = 202 bits (508), Expect = 6e-51
Identities = 135/428 (31%), Positives = 199/428 (45%), Gaps = 93/428 (21%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFI-NGKKYAVRQLPT 59
MP+++++G QWGDEGKG L + + R G NAGH+V + G+ +A+ +P+
Sbjct: 1 MPAIVLIGAQWGDEGKGKATDLLG--GRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPS 58
Query: 60 GFMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVKD-RVGIDYRCAIIEEKHKELDRTNG 118
G + ++G GV++DP V +EL L++ V ++ I ++ H +D+
Sbjct: 59 GVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISADAHLLMPYHIAIDKVTE 118
Query: 119 YLHG--KIGTTGSGCGPANADRVMRKAKQAKDI--------------------------- 149
G KIGTTG G GP D++ R + D+
Sbjct: 119 RYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHKVEAACEFKNQVLVKIYNR 178
Query: 150 KELEPY----------------LTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYV 193
K L+P + D +N AL+ G VL+EG+QG L + +GTYPYV
Sbjct: 179 KALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYV 238
Query: 194 TSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYG 251
TS + TA A GIGPTR+ V+ + K++ TRVG+GPFPTE+ E + L E+G
Sbjct: 239 TSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFG 298
Query: 252 TVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD---------------------- 289
TGRRRR GWFD +ARY+ARVNG T +T LD
Sbjct: 299 VTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEIDGRRTRDMP 358
Query: 290 --------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPEL 329
++ G ++D LP KA++++ +E+ G PV I GP
Sbjct: 359 MTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLRLEQLAGAPVSCIGVGPGR 418
Query: 330 EHIIDLRE 337
E I R+
Sbjct: 419 EQTIVRRD 426
>sp|O31047|PURA_EDWIC ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|2564709|gb|AAB86714.1| (AF026490)
adenylosuccinate synthetase [Edwardsiella ictaluri]
Length = 432
Score = 201 bits (507), Expect = 7e-51
Identities = 140/430 (32%), Positives = 195/430 (44%), Gaps = 102/430 (23%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG ++ L + + + R G NAGH++ ING+K + +P+G +
Sbjct: 4 NVVVLGTQWGDEGKGKVVDLLT--ERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEFNV--KDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++ GV++ P+ E+ L+ V ++R+ + C +I H LD
Sbjct: 62 RENVVSIIANGVVLAPDALLREMTELEARGVPVRERLLLSEACPLILPYHVALDNAREKA 121
Query: 121 HGK--IGTTGSGCGPANADRVMR----------KAKQAKDIKELEPY------------- 155
G IGTTG G GPA D+V R KA A +KE+ Y
Sbjct: 122 RGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKASFAVKLKEIMEYHNFQLVNYYHVDA 181
Query: 156 --------------------LTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTS 195
+ DVA +N A G V+ EG QG L + +GTYPYVTS
Sbjct: 182 VDYQSVLDEVMAVADLLTSMVVDVADLLNKAYRNGEYVMFEGAQGTLLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV------E 249
+ TA VA GIGP RVD V+ + K++ TRVGAGPFPTE+ D +G E
Sbjct: 242 SNTTAGGVATGSGIGPRRVDYVLGIVKAYSTRVGAGPFPTEL----FDSVGEFLCEKGNE 297
Query: 250 YGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD-------------------- 289
+G TGRRRR GW D R + +N + +T LD D
Sbjct: 298 FGATTGRRRRTGWLDAVAVRRAVELNSLSGFCLTKLDVLDGLDEVKICVGYRLPDGREVD 357
Query: 290 -----------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTG 326
+ FGV D LP+ A +I+ IEE GVPV +I TG
Sbjct: 358 VTPLAAEGWEGIEPIYEVLPGWKESTFGVKLRDGLPQAALNYIKRIEEVTGVPVDIISTG 417
Query: 327 PELEHIIDLR 336
P+ E I LR
Sbjct: 418 PDREETIVLR 427
>sp|P73290|PURA_SYNY3 ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE)
Length = 444
Score = 201 bits (507), Expect = 7e-51
Identities = 121/340 (35%), Positives = 173/340 (50%), Gaps = 50/340 (14%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
+ ++IV+G QWGDEGKG I L+ + + +GGV NAGH++ +N + + + +P+G
Sbjct: 2 LANVIVIGAQWGDEGKGKITDLLSRSADVVVRPQGGV--NAGHTIVVNDQTFKLHLIPSG 59
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDRTNGY 119
+ ++G+G ++DP+V E + L+ +V DR+ I + H+ LD+ +
Sbjct: 60 ILYPDTECIIGSGTVIDPKVLLQEFDQLEALDVSLDRLYISQTAHVTMPFHRLLDQASEE 119
Query: 120 LHG--KIGTTGSGCGPANADRVMRKAKQAKDIKE-------------------------- 151
G KIGTTG G GP AD+ R + D+
Sbjct: 120 KRGEHKIGTTGRGIGPTYADKSERMGIRVVDLMNPEILRKKLLWTVEYKNVVLDKLYDLP 179
Query: 152 -----------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
L P++ D + +I DA+ + +L EG QG L L +GTYPYVT
Sbjct: 180 PLDPETVIAEYTTYADRLRPHVVDSSLKIYDAIHQRKNILFEGAQGTLLDLDHGTYPYVT 239
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRL--GLVEYGT 252
S + A GIGPT +D VI V K++ TRVG GPFPTE+ E L E+GT
Sbjct: 240 SSNPIAGGACVGAGIGPTMIDRVIGVAKAYTTRVGEGPFPTELDGELNQHLCDRGAEFGT 299
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYDKEA 292
TGRRRR GWFD + RY+ R+NG LAIT LD D+ A
Sbjct: 300 TTGRRRRCGWFDGVIGRYAVRINGLDCLAITKLDVLDQLA 339
>sp|Q96529|PURA_ARATH ADENYLOSUCCINATE SYNTHETASE PRECURSOR (IMP--ASPARTATE LIGASE)
(ADSS) (AMPSASE) >gi|7438029|pir||T06759
adenylosuccinate synthase (EC 6.3.4.4) - Arabidopsis
thaliana >gi|1616657|gb|AAB16828.1| (U49389)
adenylosuccinate synthetase [Arabidopsis thaliana]
>gi|4678286|emb|CAB41194.1| (AL049660) adenylosuccinate
synthetase [Arabidopsis thaliana]
Length = 490
Score = 199 bits (501), Expect = 4e-50
Identities = 133/420 (31%), Positives = 199/420 (46%), Gaps = 94/420 (22%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFIN-GKKYAVRQLPTGFMQR 64
V+G QWGDEGKG ++ LA H + I+AR G NAGH+++ + GKK+A+ +P+G +
Sbjct: 71 VLGCQWGDEGKGKLVDILAQHFD--IVARCQGGANAGHTIYNSEGKKFALHLVPSGILNE 128
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNV--KDRVGIDYRCAIIEEKHKELD--RTNGYL 120
++G GV+V F E++ L+ V K R+ + R ++ + H+E+D R +
Sbjct: 129 DTTCVIGNGVVVHLPGLFKEIDGLESNGVSCKGRILVSDRAHLLFDFHQEVDGLRESELA 188
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKE----------------------------- 151
IGTT G GPA + +V+R + D++
Sbjct: 189 KSFIGTTKRGIGPAYSSKVIRNGIRVGDLRHMDTLPQKLDLLLSDAAARFQGFKYTPEML 248
Query: 152 -------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDV 198
LEPY+TD IND++ + VLVEG Q L + +GTYP+VTS
Sbjct: 249 REEVEAYKRYADRLEPYITDTVHFINDSISQKKKVLVEGGQATMLDIDFGTYPFVTSSSP 308
Query: 199 TASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGR 256
+A + +GI P+ V D+I V K++ TRVG+GPFPTE D L L E+GT TGR
Sbjct: 309 SAGGICTGLGIAPSVVGDLIGVVKAYTTRVGSGPFPTENLGTGGDLLRLAGQEFGTTTGR 368
Query: 257 RRRVGWFDFEMARYSARVNGATMLAITMLD------------------------------ 286
RR GW D ++S ++NG L +T LD
Sbjct: 369 PRRCGWLDIVALKFSCQINGFASLNLTKLDVLSDLNEIQLGVAYKRSDGTPVKSFPGDLR 428
Query: 287 -------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
+ + V +Y LP+ A++++E IEE VGVP+ I GP + +I
Sbjct: 429 LLEELHVEYEVLPGWKSDISSVRNYSDLPKAAQQYVERIEELVGVPIHYIGIGPGRDALI 488
>pdb|1DJ2|A Chain A, Structures Of Adenylosuccinate Synthetase From Triticum
Aestivum And Arabidopsis Thaliana >gi|7546403|pdb|1DJ2|B
Chain B, Structures Of Adenylosuccinate Synthetase From
Triticum Aestivum And Arabidopsis Thaliana
Length = 443
Score = 199 bits (501), Expect = 4e-50
Identities = 133/420 (31%), Positives = 199/420 (46%), Gaps = 94/420 (22%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFIN-GKKYAVRQLPTGFMQR 64
V+G QWGDEGKG ++ LA H + I+AR G NAGH+++ + GKK+A+ +P+G +
Sbjct: 24 VLGCQWGDEGKGKLVDILAQHFD--IVARCQGGANAGHTIYNSEGKKFALHLVPSGILNE 81
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNV--KDRVGIDYRCAIIEEKHKELD--RTNGYL 120
++G GV+V F E++ L+ V K R+ + R ++ + H+E+D R +
Sbjct: 82 DTTCVIGNGVVVHLPGLFKEIDGLESNGVSCKGRILVSDRAHLLFDFHQEVDGLRESELA 141
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKE----------------------------- 151
IGTT G GPA + +V+R + D++
Sbjct: 142 KSFIGTTKRGIGPAYSSKVIRNGIRVGDLRHMDTLPQKLDLLLSDAAARFQGFKYTPEML 201
Query: 152 -------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDV 198
LEPY+TD IND++ + VLVEG Q L + +GTYP+VTS
Sbjct: 202 REEVEAYKRYADRLEPYITDTVHFINDSISQKKKVLVEGGQATMLDIDFGTYPFVTSSSP 261
Query: 199 TASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGR 256
+A + +GI P+ V D+I V K++ TRVG+GPFPTE D L L E+GT TGR
Sbjct: 262 SAGGICTGLGIAPSVVGDLIGVVKAYTTRVGSGPFPTENLGTGGDLLRLAGQEFGTTTGR 321
Query: 257 RRRVGWFDFEMARYSARVNGATMLAITMLD------------------------------ 286
RR GW D ++S ++NG L +T LD
Sbjct: 322 PRRCGWLDIVALKFSCQINGFASLNLTKLDVLSDLNEIQLGVAYKRSDGTPVKSFPGDLR 381
Query: 287 -------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
+ + V +Y LP+ A++++E IEE VGVP+ I GP + +I
Sbjct: 382 LLEELHVEYEVLPGWKSDISSVRNYSDLPKAAQQYVERIEELVGVPIHYIGIGPGRDALI 441
>sp|P52151|PURA_THIFE ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|97408|pir||S23258 adenylosuccinate
synthase (EC 6.3.4.4) - Thiobacillus ferrooxidans
>gi|48168|emb|CAA40593.1| (X57324) purA [Thiobacillus
ferrooxidans] >gi|737611|prf||1923214A adenylosuccinate
synthetase [Thiobacillus ferrooxidans]
Length = 429
Score = 198 bits (499), Expect = 6e-50
Identities = 133/422 (31%), Positives = 192/422 (44%), Gaps = 93/422 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++++G QWGDEGKG I+ +L + + + R G NAGH++ I +K + +P+G +
Sbjct: 4 NVVIIGTQWGDEGKGKIVDWLT--ERCQAVVRFQGGHNAGHTLVIGARKTILHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEF--NVKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ +G GV++DP F EL+ L+ + ++R+ I C +I HK LDR
Sbjct: 62 RADVSCFIGNGVVLDPLALFSELDELRPVVPDAQERLFISDACPLILPYHKSLDRAREQA 121
Query: 121 HG--KIGTTGSGCGPANADRVMRKAKQAKDIKELE------------------------- 153
G KIGTTG G GPA D+V R+A + D+ E
Sbjct: 122 MGAAKIGTTGRGIGPAYEDKVRRRALRVADLFHRERFAAKLAEALDYHNFVLQHYFKREP 181
Query: 154 ------------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTS 195
P + DV+ + EGA +L EG QG L + +GTYP+VTS
Sbjct: 182 ENFHAILEQYLELADGLAPMVVDVSVRLARLQAEGARILFEGAQGTLLDVDHGTYPFVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGTV 253
+ A +A G+GP + V+ + K++ TRVGAGPFPTE+ E L E G
Sbjct: 242 SNTVAGGASAGSGVGPADLGYVLGITKAYTTRVGAGPFPTELFDETGVFLAERGAEVGAT 301
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGR RR GWFD R + RVNG T L IT LD D
Sbjct: 302 TGRARRCGWFDAVALRAACRVNGVTGLCITKLDVLDGLAEIRVAVGYRVNGVVQEELPGG 361
Query: 290 ------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEH 331
+ GV + LP+ A+ ++E I ER P+ +I TGP+ +
Sbjct: 362 AEALAACEPIYESFPGWSESTAGVRHWADLPQAARCYLEAIAERAERPLAIISTGPDRDD 421
Query: 332 II 333
I
Sbjct: 422 TI 423
>gi|6324109 adenylosuccinate synthetase; Ade12p [Saccharomyces cerevisiae]
>gi|1172766|sp|P80210|PURA_YEAST ADENYLOSUCCINATE
SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)
>gi|626091|pir||S48515 adenylosuccinate synthase (EC
6.3.4.4) - yeast (Saccharomyces cerevisiae)
>gi|347863|gb|AAA91338.1| (L22185) adenylosuccinate
synthetase [Saccharomyces cerevisiae]
>gi|732939|emb|CAA88590.1| (Z48671) adenylosuccinate
synthetase [Saccharomyces cerevisiae]
>gi|1302237|emb|CAA96123.1| (Z71496) ORF YNL220w
[Saccharomyces cerevisiae]
Length = 433
Score = 198 bits (497), Expect = 1e-49
Identities = 129/427 (30%), Positives = 200/427 (46%), Gaps = 100/427 (23%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ L + +I+AR G NAGH++ ++G KY LP+G +
Sbjct: 4 VVLGSQWGDEGKGKLVDLLV--GKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNP 61
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEF---NVKDRVGIDYRCAIIEEKH------KELDR 115
+ L+G GV++ FF ELE L+ N + R+ + R ++ + H +EL+
Sbjct: 62 NCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELEL 121
Query: 116 TNGYLHGK-IGTTGSGCGPANADRVMR--------------------------------- 141
+ GK IGTTG G GP + + R
Sbjct: 122 SGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQR 181
Query: 142 ----------KAKQAKDIKE-LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTY 190
K + K ++E L+P++ D +++A++ +LVEG L + +GTY
Sbjct: 182 YGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTY 241
Query: 191 PYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV-- 248
PYVTS + V +GI P +D++ V K++ TRVG GPFPTE E ++L +
Sbjct: 242 PYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGA 301
Query: 249 EYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLD---------------------- 286
E+G TGR+RR GW D + +YS +NG T L IT LD
Sbjct: 302 EFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLD 361
Query: 287 --------------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTG 326
+D++ +T Y+ LP AK++++ IE+ VGVPV + TG
Sbjct: 362 LFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKYLKYIEDFVGVPVEWVGTG 421
Query: 327 PELEHII 333
P E ++
Sbjct: 422 PARESML 428
>sp|O69595|PURA_MYCLE ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|3129993|emb|CAA18944.1| (AL023514)
adenylosuccinate synthetase [Mycobacterium leprae]
Length = 432
Score = 198 bits (497), Expect = 1e-49
Identities = 132/424 (31%), Positives = 195/424 (45%), Gaps = 93/424 (21%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFI-NGKKYAVRQLPT 59
MP+++++G QWGDEGKG + L + + R G NAGH+V + G+ + + +P+
Sbjct: 1 MPAVVLIGAQWGDEGKGKVTDLLG--GRAQWVVRYQGGNNAGHTVVLPTGENFTLHLIPS 58
Query: 60 GFMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDR-TN 117
G + ++G GV+VDP V EL+ L++ V ++ I ++ H +D+ T
Sbjct: 59 GVLTPGVTNVIGNGVVVDPGVLLSELQGLEDRGVDTSQLLISADAHLLMPYHVAIDKVTE 118
Query: 118 GYL-HGKIGTTGSGCGPANADRVMRKAKQAKDIKE------------------------- 151
Y+ + KIGTTG G GP D++ R + D+ E
Sbjct: 119 RYMGNKKIGTTGRGIGPCYQDKIARMGIRVADVLEPGELTHKIEAALEFKNQVLVKIYNR 178
Query: 152 ------------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYV 193
+TD +NDAL+ G VL+EG QG L + +GTYPYV
Sbjct: 179 KALDLAQVVETLLEQAQQFRHRITDTRLLLNDALEAGETVLLEGAQGTLLDVDHGTYPYV 238
Query: 194 TSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYG 251
TS + TA A GIGPTR+ V+ + K++ TRVG+GPFPTE+ E + L E G
Sbjct: 239 TSSNPTAGGAALGSGIGPTRIHTVLGILKAYTTRVGSGPFPTELFDENGEYLAKTGSEIG 298
Query: 252 TVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD---------------------- 289
TGRRRR GWFD +ARY+ RVNG T +T LD
Sbjct: 299 VTTGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYQIAGVRTHDMP 358
Query: 290 --------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPEL 329
++ G +++ LP KA++++ +EE G V I GP
Sbjct: 359 ITQSDLARAEPIYEELPGWWEDISGAREFEDLPAKARDYVLRLEELAGAQVACIGVGPGR 418
Query: 330 EHII 333
+ I
Sbjct: 419 DQTI 422
>sp|P29726|PURA_BACSU ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|142443|gb|AAA22203.1| (M83690)
adenylosuccinate synthetase [Bacillus subtilis]
Length = 430
Score = 197 bits (495), Expect = 2e-49
Identities = 128/418 (30%), Positives = 194/418 (45%), Gaps = 92/418 (22%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M S++VVG QWGDEGKG I +L+ + E+IAR G NAGH++ +G Y + +P+G
Sbjct: 1 MSSVVVVGTQWGDEGKGKITDFLS--ENAEVIARYQGGNNAGHTIKFDGITYKLHLIPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK-DRVGIDYRCAIIEEKHKELDRTNGY 119
+ ++G G++VDP+ EL +L E NV D + I R +I H +LD
Sbjct: 59 IFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRAHVILPYHLKLDEVEEE 118
Query: 120 LHG--KIGTTGSGCGPANADRVMRKAKQAKDI---------------------------- 149
G KIGTT G GPA D+ R + D+
Sbjct: 119 RKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKLERNLEEKNRLLEKMYETE 178
Query: 150 ---------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
++++ Y+ D + +NDALDEG VL EG QG L + GTYP+VT
Sbjct: 179 GFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVLFEGAQGVMLDIDQGTYPFVT 238
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGT 252
S + A+ + + ++ V+ V K++ TRVG GPFPTE+ E D++ V EYGT
Sbjct: 239 SSNPVAAVSQSVLVSARPKIKHVVGVSKAYTTRVGDGPFPTELKDEIGDQIREVGREYGT 298
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLD-------------------------- 286
TGR RVGWFD + R++ RV+G T L++ +D
Sbjct: 299 TTGRPPRVGWFDSVVVRHARRVSGITDLSLNSIDVLAGIETLKICVRYRYKGEIIEEFPA 358
Query: 287 ----------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPE 328
+ ++ G +LP A+ ++E + + G+P+ + GP+
Sbjct: 359 SLKALAECEPVYEEMPGWTEDITGAKSLSELPENARHYLERVSQLTGIPLSIFSVGPD 416
>sp|Q9X0I1|PURA_THEMA ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7438031|pir||B72294 adenylosuccinate
synthetase - Thermotoga maritima (strain MSB8)
>gi|4981641|gb|AAD36172.1|AE001769_2 (AE001769)
adenylosuccinate synthetase [Thermotoga maritima]
Length = 397
Score = 195 bits (490), Expect = 7e-49
Identities = 137/399 (34%), Positives = 195/399 (48%), Gaps = 73/399 (18%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+VVG QWGDEGKG ++ YL+ + + I+AR G NAGH+V K LP+ +
Sbjct: 4 VVVGLQWGDEGKGKVVTYLSRYHD--IVARFSGGANAGHTVNYGDFKVIHHLLPSADFTK 61
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEF--NVKDRVGIDYRCAIIEEKHKELDRTNGYLHG 122
+ +G+GVL+DP+V EL LKE + + I ++ HKE+DR +
Sbjct: 62 NRGIAIGSGVLLDPQVLTEELRELKEKFPDYSGEIFISESAHVVLPVHKEMDRIIDEVL- 120
Query: 123 KIGTTGSGCGPANADRVMRKAKQAKDIKELEP--------------YLTDVAAE------ 162
KIGTT G GPA ADRVMR + ++ E Y D AE
Sbjct: 121 KIGTTKRGIGPACADRVMRVNVRVAELGNEEKLRYFLEKNLSLKKIYGVDFDAEKMMGDL 180
Query: 163 ----------------INDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTASSVAAD 206
+ L+E + VL EGTQG L L GTYPYVTS + ++S V+A
Sbjct: 181 STFYETIKDFVVSPVQLKRILEEKS-VLFEGTQGVLLDLDVGTYPYVTSMNCSSSGVSAG 239
Query: 207 VGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGRRRRVGWFD 264
+G P VD+V+ VFK++ TRVG GPFPTE+ EE ++L EYG+ TGR RR GW D
Sbjct: 240 MGF-PVEVDEVLGVFKAYTTRVGEGPFPTELTGEEGEKLRKAGHEYGSTTGRPRRCGWLD 298
Query: 265 FEMARYSARVNGATMLAITMLDKYD--------------KEAFGVTDYDKLP-------- 302
+ RY+ ++G L +T D + ++ + D +K
Sbjct: 299 LPLLRYAIEISGVDSLVMTKADVLNGFEKIKVCVRYSDGRDLVSLRDLEKKEPVYEVFDG 358
Query: 303 ------RKAKEFIEEIEERVGVPVGLIKTGPELEHIIDL 335
+ + F++ IE G PV I TG +LE I+++
Sbjct: 359 WKSLEDKNFERFVDFIERETGRPVRYISTGEKLEDIVEV 397
>sp|P91134|PURA_CAEEL PROBABLE ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7497173|pir||T25612 hypothetical protein
C37H5.6 - Caenorhabditis elegans
>gi|1825781|gb|AAB42370.1| (U88315) Similar to
adenylosuccinate synthetase; coded for by C. elegans
cDNA yk104b12.3; coded for by C. elegans cDNA yk121e6.3;
coded for by C. elegans cDNA yk117a11.3; coded for by C.
elegans cDNA yk19c6.3; coded for by C. elegans cDNA
yk184h1.3; co>
Length = 457
Score = 192 bits (484), Expect = 4e-48
Identities = 131/421 (31%), Positives = 190/421 (45%), Gaps = 92/421 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+++G QWGDEGKG II YL + + + AR G NAGH+V NG+KY LP+G +
Sbjct: 33 VLLGAQWGDEGKGKIIDYLIENHKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISP 92
Query: 65 KARLLVGAGVLVDPEVFFHELEH---LKEFNVKDRVGIDYRCAIIEEKHKELD-RTNGYL 120
++G GV+V+ + FF EL H L+E + R+ I ++ H ++D R L
Sbjct: 93 TCFNVIGNGVVVNLDAFFSELAHNGILEESGWEKRIMISSEAHLVFGVHSQVDGRQEDSL 152
Query: 121 --HGKIGTTGSGCGPA------------------------------------------NA 136
KIGTT G GP N
Sbjct: 153 AAKNKIGTTNRGIGPTYSSKCFRNGIRVADLMADFEEFSEKYRRLVEHYKKQFPSIEVNV 212
Query: 137 DRVMRKAKQAKDIKELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSK 196
D + K KQ ++ + D I++ + G VLVEG G L + +GTYPYVTS
Sbjct: 213 DEELAKFKQHREKLAELKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYPYVTSS 272
Query: 197 DVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVT 254
+ T +G+ PT V +VI V K++ TRVG GPFPTE+ + ++L + E G T
Sbjct: 273 NSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTT 332
Query: 255 GRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------- 289
GR+RR GW D + R SA +NG T +A+T LD D
Sbjct: 333 GRKRRCGWIDLFLLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQA 392
Query: 290 -----------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHI 332
+ GV ++ LP K +++++ IE+ + VP+ I G E E +
Sbjct: 393 NAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCRQYVKFIEDFIKVPIVYIGVGAERESL 452
Query: 333 I 333
I
Sbjct: 453 I 453
>sp|O24578|PURA_MAIZE ADENYLOSUCCINATE SYNTHETASE PRECURSOR (IMP--ASPARTATE LIGASE)
(ADSS) (AMPSASE) >gi|7438030|pir||T03984
adenylosuccinate synthase (EC 6.3.4.4) - maize
>gi|1616661|gb|AAB16830.1| (U49388) adenylosuccinate
synthetase [Zea mays]
Length = 484
Score = 190 bits (479), Expect = 1e-47
Identities = 126/420 (30%), Positives = 198/420 (47%), Gaps = 94/420 (22%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFIN-GKKYAVRQLPTGFMQR 64
V+G QWGDEGKG ++ LA +I+AR G NAGH+++ + GKK+A+ +P+G +
Sbjct: 65 VLGSQWGDEGKGKLVDVLA--PRFDIVARCQGGANAGHTIYNSEGKKFALHLVPSGILHE 122
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVK--DRVGIDYRCAIIEEKHKELD--RTNGYL 120
+VG G ++ FF E++ L+ V+ R+ + R ++ + H+ +D R
Sbjct: 123 GTLCVVGNGAVIHVPGFFGEIDGLESNGVRCGGRILVSDRAHLLFDLHQAVDGLREAELE 182
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKE----------------------------- 151
+ IGTT G GP + +V R + D++
Sbjct: 183 NSFIGTTKRGIGPCYSSKVTRNGLRVCDLRHMDTFGDKLDILFKDAASRFQGFQYSKSLL 242
Query: 152 -------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDV 198
LEP++ D +N+++ + +LVEG Q L + +GTYP+VTS
Sbjct: 243 KEEVERYKKFADRLEPFIADTVHVLNESIKQKKKILVEGGQATMLDIDFGTYPFVTSSSP 302
Query: 199 TASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRL--GLVEYGTVTGR 256
+A + +GI P + D+I V K++ +RVG+GPFPTE+ EE DRL +E+GT TGR
Sbjct: 303 SAGGICTGLGIAPRAIGDLIGVVKAYTSRVGSGPFPTELFGEEGDRLRKAGMEFGTTTGR 362
Query: 257 RRRVGWFDFEMARYSARVNGATMLAITMLD------------------------------ 286
RR GW D ++S ++NG + L +T LD
Sbjct: 363 PRRCGWLDIVALKHSCQINGFSSLNLTKLDVLSGLSEIKVGVSYTQTDGQKLQSFPGDLD 422
Query: 287 -------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
+ + V YD+LP+ A+ ++E IEE VGVPV I GP + +I
Sbjct: 423 TLEQVQVNYEVLPGWQSDISSVRRYDELPQAARLYVERIEELVGVPVHYIGVGPGRDALI 482
>sp|O67321|PURA_AQUAE ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7438027|pir||F70411 adenylosuccinate
synthetase - Aquifex aeolicus >gi|2983724|gb|AAC07286.1|
(AE000733) adenylosuccinate synthetase [Aquifex
aeolicus]
Length = 432
Score = 190 bits (477), Expect = 2e-47
Identities = 135/426 (31%), Positives = 199/426 (46%), Gaps = 92/426 (21%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M LI++G QWGDEGKG I+ L+ H + + +GG +NAGH+V +N +K+ + LPTG
Sbjct: 1 MEKLIILGAQWGDEGKGKIVDLLSEHFDITVRYQGG--SNAGHTVVVNSQKFILHLLPTG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELDRTNG 118
+ + ++ G++VD EV E+++L+E VK+R+ I R ++ HK LD
Sbjct: 59 ILHEHVKGVIAQGMVVDLEVLHKEVKNLEEKGIYVKERLFISDRAHLVMPYHKLLDSLFE 118
Query: 119 YLHGKIGTTGSGCGPANADRVMRKAKQAKDIKELEPYLT-------------------DV 159
G IGTT G GPA + RK + D+K+ + + T
Sbjct: 119 KKKG-IGTTLRGIGPAYMFKYGRKGIRISDLKDEKRFYTLLEDNLDFVKNICEKVFCEKF 177
Query: 160 AAEINDALDE----------------------GALVLVEGTQGFGLSLYYGTYPYVTSKD 197
+IN +E VL EG QG L + GTYPYVTS +
Sbjct: 178 DLDINQIYEEQLRYFEEFKENVVDLLRFFNTQKGSVLFEGAQGTLLDVDMGTYPYVTSSN 237
Query: 198 VTASSVAADVGIGPTRVDDV--IVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTV 253
+A ++ G+ P D + V K++ TRVG GPFPTE+ EE ++L + EYG+
Sbjct: 238 ASALGLSNGTGMPPKYFSDAFFLGVAKAYTTRVGEGPFPTELKGEEGEKLRELGGEYGST 297
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGR RR GW D +Y+ +VNG IT LD D
Sbjct: 298 TGRPRRCGWLDLVALKYAVQVNGLDGFVITKLDVLDTFDEVKVCVAYELDGEVIDYFPAS 357
Query: 290 ------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEH 331
K G D +LP++A ++++ IEE GVPV ++ TGP+ +
Sbjct: 358 YSELIRVKPVYKTLKGWKKSTKGAKDVSELPKEALDYVKFIEEYTGVPVVMLSTGPKRDE 417
Query: 332 IIDLRE 337
I L+E
Sbjct: 418 YIWLKE 423
>sp|O24396|PURA_WHEAT ADENYLOSUCCINATE SYNTHETASE PRECURSOR (IMP--ASPARTATE LIGASE)
(ADSS) (AMPSASE) >gi|7438028|pir||T06792
adenylosuccinate synthase (EC 6.3.4.4) - wheat
(fragment) >gi|1616659|gb|AAB16829.1| (U49387)
adenylosuccinate synthetase [Triticum aestivum]
Length = 476
Score = 188 bits (473), Expect = 7e-47
Identities = 125/420 (29%), Positives = 193/420 (45%), Gaps = 94/420 (22%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFIN-GKKYAVRQLPTGFMQR 64
V+G QWGDEGKG ++ LA +I+AR G NAGH+++ + GKK+A+ +P+G +
Sbjct: 57 VLGSQWGDEGKGKLVDVLA--PRFDIVARCQGGANAGHTIYNSEGKKFALHLVPSGILHE 114
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVK--DRVGIDYRCAIIEEKHKELD--RTNGYL 120
+VG G ++ FF E++ L+ V R+ + R ++ + H+ +D R
Sbjct: 115 GTLCVVGNGAVIHVPGFFGEIDGLQSNGVSCDGRILVSDRAHLLFDLHQTVDGLREAELA 174
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKE----------------------------- 151
+ IGTT G GP + +V R + D++
Sbjct: 175 NSFIGTTKRGIGPCYSSKVTRNGLRVCDLRHMDTFGDKLDVLFEDAAARFEGFKYSKGML 234
Query: 152 -------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDV 198
LEP++ D +N+++ + +LVEG Q L + +GTYP+VTS
Sbjct: 235 KEEVERYKRFAERLEPFIADTVHVLNESIRQKKKILVEGGQATMLDIDFGTYPFVTSSSP 294
Query: 199 TASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEAD--RLGLVEYGTVTGR 256
+A + +GI P + D+I V K++ TRVG+GPFPTE+ EE D R +E+GT TGR
Sbjct: 295 SAGGICTGLGIAPRVIGDLIGVVKAYTTRVGSGPFPTELLGEEGDVLRKAGMEFGTTTGR 354
Query: 257 RRRVGWFDFEMARYSARVNGATMLAITMLD------------------------------ 286
RR GW D +Y +NG + L +T LD
Sbjct: 355 PRRCGWLDIVALKYCCDINGFSSLNLTKLDVLSGLPEIKLGVSYNQMDGEKLQSFPGDLD 414
Query: 287 -------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
+D + V Y +LP+ A+ ++E IEE GVPV I GP + +I
Sbjct: 415 TLEQVQVNYEVLPGWDSDISSVRSYSELPQAARRYVERIEELAGVPVHYIGVGPGRDALI 474
>pdb|1DJ3|A Chain A, Structures Of Adenylosuccinate Synthetase From Triticum
Aestivum And Arabidopsis Thaliana >gi|7546405|pdb|1DJ3|B
Chain B, Structures Of Adenylosuccinate Synthetase From
Triticum Aestivum And Arabidopsis Thaliana
Length = 442
Score = 188 bits (473), Expect = 7e-47
Identities = 125/420 (29%), Positives = 193/420 (45%), Gaps = 94/420 (22%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFIN-GKKYAVRQLPTGFMQR 64
V+G QWGDEGKG ++ LA +I+AR G NAGH+++ + GKK+A+ +P+G +
Sbjct: 23 VLGSQWGDEGKGKLVDVLA--PRFDIVARCQGGANAGHTIYNSEGKKFALHLVPSGILHE 80
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVK--DRVGIDYRCAIIEEKHKELD--RTNGYL 120
+VG G ++ FF E++ L+ V R+ + R ++ + H+ +D R
Sbjct: 81 GTLCVVGNGAVIHVPGFFGEIDGLQSNGVSCDGRILVSDRAHLLFDLHQTVDGLREAELA 140
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKE----------------------------- 151
+ IGTT G GP + +V R + D++
Sbjct: 141 NSFIGTTKRGIGPCYSSKVTRNGLRVCDLRHMDTFGDKLDVLFEDAAARFEGFKYSKGML 200
Query: 152 -------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDV 198
LEP++ D +N+++ + +LVEG Q L + +GTYP+VTS
Sbjct: 201 KEEVERYKKFAERLEPFIADTVHVLNESIRQKKKILVEGGQATMLDIDFGTYPFVTSSSP 260
Query: 199 TASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEAD--RLGLVEYGTVTGR 256
+A + +GI P + D+I V K++ TRVG+GPFPTE+ EE D R +E+GT TGR
Sbjct: 261 SAGGICTGLGIAPRVIGDLIGVVKAYTTRVGSGPFPTELLGEEGDVLRKAGMEFGTTTGR 320
Query: 257 RRRVGWFDFEMARYSARVNGATMLAITMLD------------------------------ 286
RR GW D +Y +NG + L +T LD
Sbjct: 321 PRRCGWLDIVALKYCCDINGFSSLNLTKLDVLSGLPEIKLGVSYNQMDGEKLQSFPGDLD 380
Query: 287 -------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
+D + V Y +LP+ A+ ++E IEE GVPV I GP + +I
Sbjct: 381 TLEQVQVNYEVLPGWDSDISSVRSYSELPQAARRYVERIEELAGVPVHYIGVGPGRDALI 440
>gb|AAA75455.1| (L43054) adenylosuccinate synthetase [Brucella abortus]
Length = 401
Score = 182 bits (458), Expect = 4e-45
Identities = 119/338 (35%), Positives = 173/338 (50%), Gaps = 53/338 (15%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M +++VVG QWGDEGKG I+ +L+ + ++I R G NAGH++ I+G Y + LP+G
Sbjct: 1 MANVVVVGSQWGDEGKGKIVDWLS--ERADVIVRYQGGHNAGHTLVIDGVSYKLSLLPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK---DRVGIDYRCAIIEEKHKELD--R 115
++ K + +G GV+VDP F E+E L+ + D + + +I H+ELD R
Sbjct: 59 LVRGKLSV-IGNGVVVDPHHFVAEVEKLRGQGIDVTPDVLRVAENAPLILSIHRELDAMR 117
Query: 116 TNGYLHGKIGTTGSGCGPANADRVMRKAKQAKDIKELE---------------------- 153
KIGTT G GPA D+V R+A + D+ E E
Sbjct: 118 EGSNSGLKIGTTKRGIGPAYEDKVGRRAIRVIDLTEPETLRPKVERLLAHHNSLRRGMGL 177
Query: 154 --------------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYV 193
PY+ V +++ GA +L EG + L +GTYP+V
Sbjct: 178 EEIAVETILTELTSVADQILPYIDQVWRVLDERRKRGARILFEGRRAL-LDNDHGTYPFV 236
Query: 194 TSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYG 251
TS + A AA G+GPT + V+ + K++ TRVG GPFPTE+ E + LG E+G
Sbjct: 237 TSSNTVAGQAAAGSGLGPTAIGYVLGITKAYTTRVGEGPFPTELNDEIGEFLGTKGHEFG 296
Query: 252 TVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD 289
VTGR+RR GWFD + R + R +G +A+T LD D
Sbjct: 297 VVTGRKRRCGWFDAVIVRQTVRTSGINGIALTKLDVLD 334
>sp|P52004|PURA_BRUAB ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE)
Length = 402
Score = 182 bits (458), Expect = 4e-45
Identities = 119/338 (35%), Positives = 173/338 (50%), Gaps = 53/338 (15%)
Query: 1 MPSLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTG 60
M +++VVG QWGDEGKG I+ +L+ + ++I R G NAGH++ I+G Y + LP+G
Sbjct: 1 MANVVVVGSQWGDEGKGKIVDWLS--ERADVIVRYQGGHNAGHTLVIDGVSYKLSLLPSG 58
Query: 61 FMQRKARLLVGAGVLVDPEVFFHELEHLKEFNVK---DRVGIDYRCAIIEEKHKELD--R 115
++ K + +G GV+VDP F E+E L+ + D + + +I H+ELD R
Sbjct: 59 LVRGKLSV-IGNGVVVDPHHFVAEVEKLRGQGIDVTPDVLRVAENAPLILSIHRELDAMR 117
Query: 116 TNGYLHGKIGTTGSGCGPANADRVMRKAKQAKDIKELE---------------------- 153
KIGTT G GPA D+V R+A + D+ E E
Sbjct: 118 EGSNSGLKIGTTKRGIGPAYEDKVGRRAIRVIDLTEPETLRPKVERLLAHHNSLRRGMGL 177
Query: 154 --------------------PYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYV 193
PY+ V +++ GA +L EG + L +GTYP+V
Sbjct: 178 EEIAVETILTELTSVADQILPYIDQVWRVLDERRKRGARILFEGRRAL-LDNDHGTYPFV 236
Query: 194 TSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYG 251
TS + A AA G+GPT + V+ + K++ TRVG GPFPTE+ E + LG E+G
Sbjct: 237 TSSNTVAGQAAAGSGLGPTAIGYVLGITKAYTTRVGEGPFPTELNDEIGEFLGTKGHEFG 296
Query: 252 TVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD 289
VTGR+RR GWFD + R + R +G +A+T LD D
Sbjct: 297 VVTGRKRRCGWFDAVIVRQTVRTSGINGIALTKLDVLD 334
>gb|AAG01122.1|AF273333_7 (AF273333) BAC19.7 [Lycopersicon esculentum]
Length = 581
Score = 182 bits (457), Expect = 5e-45
Identities = 120/405 (29%), Positives = 188/405 (45%), Gaps = 94/405 (23%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFIN-GKKYAVRQLPTGFMQR 64
V+G QWGDEGKG ++ LA H + I+AR G NAGH+++ + GKK+A+ +P+G +
Sbjct: 81 VLGCQWGDEGKGKLVDILAKHFD--IVARCQGGANAGHTIYNSEGKKFALHLVPSGILNE 138
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNV--KDRVGIDYRCAIIEEKHKELD--RTNGYL 120
+ ++G GV+V F E++ L+ V + R+ + R ++ + H+E+D R
Sbjct: 139 ETLCVIGNGVVVHLPGLFKEIDGLEANGVSCQGRILVSDRAHLLFDFHQEIDGLREAELA 198
Query: 121 HGKIGTTGSGCGPANADRVMRKAKQAKDIKE----------------------------- 151
IGTT G GP + +V+R + D++
Sbjct: 199 KSFIGTTKRGIGPCYSSKVIRNGLRVSDLRHMDTFPQKLDLLLSDAAARFPGFKYGPDML 258
Query: 152 -------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDV 198
LEP++TD +NDA+ + +LVEG Q L + +GTYP+VTS
Sbjct: 259 REEVERYKKFAERLEPFVTDTVHFMNDAISQKKKILVEGGQATMLDIDFGTYPFVTSSSP 318
Query: 199 TASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGR 256
+A + +GI P V D++ V K++ TRVG+GPFPTE+ + D L E+GT TGR
Sbjct: 319 SAGGICTGLGIAPKVVGDLVGVVKAYTTRVGSGPFPTEIMGKGGDLLRFAGQEFGTTTGR 378
Query: 257 RRRVGWFDFEMARYSARVNGATMLAITMLD------------------------------ 286
RR GW D ++ ++NG L +T LD
Sbjct: 379 PRRCGWLDIVALKFCCQINGFASLNLTKLDVLSDLPEIQLGVTYRHPDGSALHSFPSDLR 438
Query: 287 -------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGV 318
+ + + Y LP+ A+E++E IEE VG+
Sbjct: 439 LLEQIKVEYEVLPGWKSDISSIRKYSDLPKAAREYVERIEELVGL 483
>sp|Q9ZMI1|PURA_HELPJ ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7438024|pir||A71955 adenylosuccinate
synthetase - Helicobacter pylori (strain J99)
>gi|4154770|gb|AAD05829.1| (AE001462) ADENYLOSUCCINATE
SYNTHETASE [Helicobacter pylori J99]
Length = 411
Score = 177 bits (444), Expect = 2e-43
Identities = 123/413 (29%), Positives = 191/413 (45%), Gaps = 87/413 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+VVG QWGDEGKG I+ +A + + + R G NAGH++ G K+++ +P+G +
Sbjct: 4 VVVGIQWGDEGKGKIVDRIA--KDYDFVVRYQGGHNAGHTIVHKGVKHSLHLMPSGVLYP 61
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYLHGKI 124
K + ++ + V+V + E+ ++ +++R+ I R +I H + D I
Sbjct: 62 KCKNIISSAVVVSVKDLCEEISAFED--LENRLFISDRAHVILPYHAKKDAFKEKSQN-I 118
Query: 125 GTTGSGCGPANADRVMRKA--------------------------KQAKDIKE------- 151
GTT G GP D++ R K+A D+ E
Sbjct: 119 GTTKKGIGPCYEDKMARSGIRMGDLLDDKILEEKLNAHFKAIEPFKKAYDLGENYEKDLM 178
Query: 152 ---------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTASS 202
+ P++ D + + +A +G +L+EG QG L + GTYP+VTS + T++S
Sbjct: 179 GYFKTYAPKICPFIKDTTSMLIEANQKGEKILLEGAQGTLLDIDLGTYPFVTSSNTTSAS 238
Query: 203 VAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTE--MPMEEADRLGLVEYGTVTGRRRRV 260
G+ P +++VI + K++ TRVG GPFP+E PM + R VE+GT T R RR
Sbjct: 239 ACVSTGLNPKAINEVIGITKAYSTRVGNGPFPSEDTTPMGDHLRTKGVEFGTTTKRPRRC 298
Query: 261 GWFDFEMARYSARVNGATMLAITMLDKYD------------------------------- 289
GW D +Y+ +NG T LA+ LD D
Sbjct: 299 GWLDLVALKYACALNGCTQLALMKLDVLDGIDAIKVCVAYERKGERLEAFPSDLKDCTPI 358
Query: 290 -------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDL 335
+++ GV D L A+E+I IE+ VGV +GLI T PE E I L
Sbjct: 359 YQTFKGWEKSVGVRKLDDLEPNAREYIRFIEKEVGVKIGLISTSPEREDTIFL 411
>pir||S77471 adenylosuccinate synthase (EC 6.3.4.4) - Synechocystis sp. (strain
PCC 6803) >gi|1652396|dbj|BAA17318.1| (D90905)
adenylosuccinate synthetase [Synechocystis sp.]
Length = 415
Score = 177 bits (444), Expect = 2e-43
Identities = 107/310 (34%), Positives = 153/310 (48%), Gaps = 48/310 (15%)
Query: 31 IIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQRKARLLVGAGVLVDPEVFFHELEHLKE 90
++ R G NAGH++ +N + + + +P+G + ++G+G ++DP+V E + L+
Sbjct: 1 MVVRPQGGVNAGHTIVVNDQTFKLHLIPSGILYPDTECIIGSGTVIDPKVLLQEFDQLEA 60
Query: 91 FNVK-DRVGIDYRCAIIEEKHKELDRTNGYLHG--KIGTTGSGCGPANADRVMRKAKQAK 147
+V DR+ I + H+ LD+ + G KIGTTG G GP AD+ R +
Sbjct: 61 LDVSLDRLYISQTAHVTMPFHRLLDQASEEKRGEHKIGTTGRGIGPTYADKSERMGIRVV 120
Query: 148 DIKE-------------------------------------------LEPYLTDVAAEIN 164
D+ L P++ D + +I
Sbjct: 121 DLMNPEILRKKLLWTVEYKNVVLDKLYDLPPLDPETVIAEYTTYADRLRPHVVDSSLKIY 180
Query: 165 DALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSF 224
DA+ + +L EG QG L L +GTYPYVTS + A GIGPT +D VI V K++
Sbjct: 181 DAIHQRKNILFEGAQGTLLDLDHGTYPYVTSSNPIAGGACVGAGIGPTMIDRVIGVAKAY 240
Query: 225 PTRVGAGPFPTEMPMEEADRL--GLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAI 282
TRVG GPFPTE+ E L E+GT TGRRRR GWFD + RY+ R+NG LAI
Sbjct: 241 TTRVGEGPFPTELDGELNQHLCDRGAEFGTTTGRRRRCGWFDGVIGRYAVRINGLDCLAI 300
Query: 283 TMLDKYDKEA 292
T LD D+ A
Sbjct: 301 TKLDVLDQLA 310
>gb|AAG19487.1| (AE005041) adenylosuccinate synthase; PurA [Halobacterium sp.
NRC-1]
Length = 440
Score = 174 bits (437), Expect = 1e-42
Identities = 125/440 (28%), Positives = 197/440 (44%), Gaps = 108/440 (24%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
++ +VG Q GDEGKG ++ D +++ R G NAGH+V G++Y + +P+G +
Sbjct: 2 TVTIVGAQLGDEGKGGVVDLFG--DATDVVVRYQGGDNAGHTVVAGGEEYKLSLVPSGVV 59
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELD----RTNG 118
+ K +L G G +++PE F E++ L+E + V + R +I H+ELD
Sbjct: 60 RGKTGVL-GNGCVINPETLFEEVDALRERGLDPDVRLAKRAHVILPFHRELDGAEEAAKA 118
Query: 119 YLHGKIGTTGSGCGPANADRVMRKAKQAKDI------KELEPYLTDV------------A 160
+IGTTG G GP D++ R+ + D+ ++ YL D A
Sbjct: 119 DSDSEIGTTGRGIGPTYEDKIGRRGVRVGDLLNEDALRDRLEYLVDAKRAIYEDVYGFDA 178
Query: 161 AEINDALD---------------------------------EGALVLVEGTQGFGLSLYY 187
+E + A D +G V++EG QG L + +
Sbjct: 179 SETDGAFDIDAIHEQCLAYADRIRDEDLAVNAGDYLADRIADGDNVMLEGAQGTSLDIDH 238
Query: 188 GTYPYVTSKDVTASSVAADVGIGPTRVD--DVIVVFKSFPTRVGAGPFPTEMPMEEADRL 245
G +PYVTS + TA A G+GPT V +++ + K++ +RVG+GP PTE+ ++A+ +
Sbjct: 239 GNFPYVTSSNPTAGYAATGSGLGPTTVGQGEIVGIIKAYLSRVGSGPMPTELDGDQAEYI 298
Query: 246 GLV--EYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLD----------------- 286
EYGTVTGR RRVGW D M R++AR NG T +AI LD
Sbjct: 299 REEGGEYGTVTGRPRRVGWLDMPMLRHAARANGFTGIAINHLDVLAELDEVNVGHAYERD 358
Query: 287 ----------------------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGV 318
+D Y LP A+ ++E +E +
Sbjct: 359 GERIHTLPATTEAWRDCDPVMKSFDGWSAFDPAVVADAGYSALPDNAQAYVEYVEAELDT 418
Query: 319 PVGLIKTGPELEHIIDLREN 338
P ++ GP E + +R+N
Sbjct: 419 PAYVLGVGPGREESV-IRQN 437
>sp|P57629|PURA_BUCAI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|10039222|dbj|BAB13256.1| (AP001119)
adenylosuccinate synthetase [Buchnera sp. APS]
Length = 433
Score = 172 bits (432), Expect = 5e-42
Identities = 119/427 (27%), Positives = 188/427 (43%), Gaps = 95/427 (22%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++++G QWGDEGKG ++ L + + R G NAGH++ +N KK + +P+G +
Sbjct: 4 NIVILGTQWGDEGKGKVVDCLT--KDSSYVVRYQGGHNAGHTLVVNDKKIILHLIPSGLL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKEFN--VKDRVGIDYRCAIIEEKHKELDRTNGYL 120
+ ++ GV+V P E++ L+ N V R+ I +I + H E+D
Sbjct: 62 HKNVIGIIANGVVVSPFELIKEIKMLETHNIFVHKRLFISNSSPLILQYHIEMDIAREKK 121
Query: 121 HG--KIGTTGSGCGPANADRVMRKAKQAKDIKE--------------------------- 151
G +GTTG G GPA D++ R+A + D+K
Sbjct: 122 LGISALGTTGRGIGPAYEDKIARRALRIGDLKNEKTLSIRLEKIVNYYNHQLVSFYKHKP 181
Query: 152 ----------------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTS 195
+ + D + ++ A+ ++ EG QG L + +GTYPYVTS
Sbjct: 182 VDYKIILRDLLPTIDLIYDMIKDTTSILHTAIQSNKKIIFEGAQGSFLDIDHGTYPYVTS 241
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV---EYGT 252
+ T V G+G +D ++ V K++ TRVG GPFPTE+ ++ D+ E+G+
Sbjct: 242 SNSTIGGVITGTGVGSKSLDYILGVTKAYSTRVGYGPFPTEL-FDDVDKHFSKKGHEFGS 300
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD----------------------- 289
TGR+RR GW D S R+N + L IT LD D
Sbjct: 301 TTGRKRRTGWLDAVALCRSVRINSLSGLCITKLDVLDGLHEIKICTAYKNINTLEIISFP 360
Query: 290 -------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELE 330
K+ G+ LP +A+ +I IEE +PV +I TGP+
Sbjct: 361 DIDEWKNIEPIYETYPGWNKKTLGIKKLIDLPYEARNYINRIEEITQIPVDIISTGPDRS 420
Query: 331 HIIDLRE 337
II +R+
Sbjct: 421 DIIFVRD 427
>sp|P56137|PURA_HELPY ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|7438025|pir||G64551 adenylosuccinate
synthetase - Helicobacter pylori (strain 26695)
>gi|2313350|gb|AAD07324.1| (AE000545) adenylosuccinate
synthetase (purA) [Helicobacter pylori 26695]
Length = 411
Score = 170 bits (427), Expect = 2e-41
Identities = 119/413 (28%), Positives = 188/413 (44%), Gaps = 87/413 (21%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+VVG QWGDEGKG I+ +A + + + R G NAGH++ G K+++ +P+G +
Sbjct: 4 VVVGIQWGDEGKGKIVDRIA--KDYDFVVRYQGGHNAGHTIVHKGVKHSLHLMPSGVLYP 61
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYLHGKI 124
K + ++ + V+V + E+ ++ +++R+ + R +I H + D I
Sbjct: 62 KCKNIISSAVVVSVKDLCEEISAFED--LENRLFVSDRAHVILPYHAKKDAFKEKSQN-I 118
Query: 125 GTTGSGCGPANADRVMRKA--------------------------KQAKDIKE------- 151
GTT G GP D++ R K+A D+ E
Sbjct: 119 GTTKKGIGPCYEDKMARSGIRMGDLLDDKILEEKLNAHFKAIEPFKKAYDLGENYEKDLM 178
Query: 152 ---------LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTASS 202
+ P++ D + + +A +G +L+EG QG L + GTYP+VTS + T++S
Sbjct: 179 GYFKTYAPKICPFIKDTTSMLIEANQKGEKILLEGAQGTLLDIDLGTYPFVTSSNTTSAS 238
Query: 203 VAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTE--MPMEEADRLGLVEYGTVTGRRRRV 260
G+ P +++VI + K++ TRVG GPFP+E PM + R E+GT T R RR
Sbjct: 239 ACVSTGLNPKAINEVIGITKAYSTRVGNGPFPSEDTTPMGDHLRTKGAEFGTTTKRPRRC 298
Query: 261 GWFDFEMARYSARVNGATMLAITMLDKYD------------------------------- 289
GW D +Y+ +NG T LA+ LD D
Sbjct: 299 GWLDLVALKYACALNGCTQLALMKLDVLDGIDAIKVCVAYERKGERLEIFPSDLKDCVPI 358
Query: 290 -------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHIIDL 335
+++ GV D L +E+I IE+ VGV + LI T PE E I L
Sbjct: 359 YQTFKGWEKSVGVRKLDDLEPNVREYIRFIEKEVGVKIRLISTSPEREDTIFL 411
>sp|P52150|PURA_SPICI ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|413756|gb|AAA26586.1| (L22971)
adenylosuccinate lyase [Spiroplasma citri]
Length = 435
Score = 166 bits (416), Expect = 3e-40
Identities = 121/437 (27%), Positives = 199/437 (44%), Gaps = 110/437 (25%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+L +VG QWGDEGKG I Y A + ++I R G NAGH++ I KY + +P+G
Sbjct: 8 TLAIVGSQWGDEGKGKITDYFA--QQADLIVRWAGGDNAGHTIVIKRNKYKLSIVPSGAF 65
Query: 63 QRKARLLVGAGVLVDPEVFF---------HELEHLKEFNVKDRVGI--DYRCAI--IEEK 109
+K+ ++G V+V+ H + LK + DRV + Y I ++E+
Sbjct: 66 NKKSMNVIGMVVVVNLRKLSYGNWVIYKQHGFDLLKNLRISDRVHLIFPYHMKIDELQEE 125
Query: 110 HKELDRTNGYLHGKIGTTGSGCGPANADR------------------------------V 139
+++ D IGTT G GP D+ V
Sbjct: 126 YRQKD--------SIGTTKKGIGPCYQDKAERIGIRLGDLFDEKGFLQKLENNLKFKNEV 177
Query: 140 MRKAKQAKDI-------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLY 186
++K KD+ ++++ +TD + +++A+ ++ QG L L
Sbjct: 178 LQKFLIVKDLTKINLKRIFWHYFQQIKSLVTDTSILVDNAIHNHQKFYLKEAQGVMLDLD 237
Query: 187 YGTYPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEM--PMEEADR 244
+GTYP+VTS + TASS+ VGI P +++V+ + K++ TRVG GPFP+E+ +E R
Sbjct: 238 HGTYPFVTSSNPTASSIPVGVGIAPRYINNVLGIVKAYNTRVGTGPFPSEIFGEVETYIR 297
Query: 245 LGLVEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLD------------------ 286
EYGTV+GR R +GWFD + ++S + + I +LD
Sbjct: 298 EAGHEYGTVSGRARWIGWFDGILMKHSRELVVILVWLIMLLDVLTTIKELKICVGYEYQG 357
Query: 287 ------------------------KYDKEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGL 322
+D++ VT ++ LP A++++ ++EE VGVP+ L
Sbjct: 358 QQIDYVPSTIKEYEMCKPILITMPGWDEDISNVTTFEGLPHNAQQYLMKLEEIVGVPISL 417
Query: 323 IKTGPELEHIIDLRENI 339
GP+ E I + + I
Sbjct: 418 FSVGPDREQTILMNKEI 434
>emb|CAC12488.1| (AL445067) probable adenylosuccinate synthetase [Thermoplasma
acidophilum]
Length = 460
Score = 164 bits (411), Expect = 1e-39
Identities = 120/416 (28%), Positives = 190/416 (44%), Gaps = 96/416 (23%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQRK 65
VVG Q+GDEGKG I YL+ +++ R GTNAGH+V + + LP+G + R
Sbjct: 39 VVGLQFGDEGKGKITDYLS--GSYDVVVRFNGGTNAGHTVVTDEGTFKFHLLPSGSL-RT 95
Query: 66 ARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELDRTNGYLHGK-- 123
+ +++G+G+++DP E+E +++ N ++ I ++ + H+++D +
Sbjct: 96 SYVVLGSGMVIDPVALIPEIEIVRKINPALKIIISRNAHVVTKMHRQIDVEEEKIRSSLM 155
Query: 124 IGTTGSGCGPANADRVMR---------------------------------------KAK 144
IGTT G GP D+ R + +
Sbjct: 156 IGTTAQGIGPTYEDKYARTGIRMVDISDIDLIKEKIETMYRMHSNLLANTEFSNLAKREE 215
Query: 145 QAKDIKE----LEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTA 200
AK+I E L YL I+ +G +L EG QG L +G YP+VTS + +
Sbjct: 216 MAKEIYEAGIKLTGYLDYTEVAIDRLYSQGKRILFEGAQGVFLDPDFGFYPFVTSSNTIS 275
Query: 201 SSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGRRR 258
+SV G +V+ +I V K++ ++VG GPFPTE+ + A +L + EYGT TGR R
Sbjct: 276 ASVYTGTGFSLRKVNRIIGVAKAYVSKVGEGPFPTEITGDLAKQLRDLGGEYGTTTGRPR 335
Query: 259 RVGWFDFEMARYSARVNGATMLAITMLDK------------------------------- 287
RVGW D M +Y+ R++ +AIT +D
Sbjct: 336 RVGWLDLPMLKYAVRIDDVDEIAITKVDTLGMLDTVKVCRQYLIDGKPIDYVPRDMNTIK 395
Query: 288 -----YDK-EAFGV---------TDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPE 328
YD+ E +G D+LP K ++I+ IE++VG P+G+I G E
Sbjct: 396 KIEPVYDEFEGWGAISDSISGRKISIDQLPSKLVKYIKYIEDQVGKPIGIISMGKE 451
>gi|6671519 adenylosuccinate synthetase 1, muscle [Mus musculus]
>gi|1346910|sp|P28650|PUA1_MOUSE ADENYLOSUCCINATE
SYNTHETASE, MUSCLE ISOZYME (IMP--ASPARTATE LIGASE)
(ADSS) (AMPSASE) >gi|404751|gb|AAA82870.1| (M74495)
adenylosuccinate synthetase [Mus musculus]
Length = 457
Score = 163 bits (409), Expect = 2e-39
Identities = 124/424 (29%), Positives = 183/424 (42%), Gaps = 95/424 (22%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I++R G NAGH+V ++GK+Y LP+G +
Sbjct: 35 VVLGAQWGDEGKGKVVDLLAT--DADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINT 92
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKD---RVGIDYRCAIIEEKHKELDRTNGYLH 121
KA +G GV++ F E E ++ +KD R+ I R ++ + H+ +D
Sbjct: 93 KAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQR 152
Query: 122 ----GK-IGTTGSGCGPANADRVMRKAKQAKDI--------------------------- 149
GK IGTT G GP + + R + D+
Sbjct: 153 QAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEI 212
Query: 150 -------------KELEPYLTDVAAEINDALD-EGALVLVEGTQGFGLSLYYGTYPYVTS 195
+ + P + D + +AL VLVEG L + +GTYP+VTS
Sbjct: 213 DVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTS 272
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGTV 253
+ T V +GI P + DV V K++ TRVG G FPTE E D L E+G
Sbjct: 273 SNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVT 332
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGR+RR GW D + RY+ VNG T LA+T LD D
Sbjct: 333 TGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPAN 392
Query: 290 ------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEH 331
+ G ++ LP +A+ ++ +E +GV V + G E
Sbjct: 393 QEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHMGVAVKWVGVGKSRES 452
Query: 332 IIDL 335
+I L
Sbjct: 453 MIQL 456
>prf||2122208A adenylosuccinate synthetase:ISOTYPE=muscle [Mus musculus]
Length = 457
Score = 163 bits (409), Expect = 2e-39
Identities = 124/424 (29%), Positives = 183/424 (42%), Gaps = 95/424 (22%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I++R G NAGH+V ++GK+Y LP+G +
Sbjct: 35 VVLGAQWGDEGKGKVVDLLAT--DADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINT 92
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKD---RVGIDYRCAIIEEKHKELDRTNGYLH 121
KA +G GV++ F E E ++ +KD R+ I R ++ + H+ +D
Sbjct: 93 KAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQR 152
Query: 122 ----GK-IGTTGSGCGPANADRVMRKAKQAKDI--------------------------- 149
GK IGTT G GP + + R + D+
Sbjct: 153 QAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEI 212
Query: 150 -------------KELEPYLTDVAAEINDALD-EGALVLVEGTQGFGLSLYYGTYPYVTS 195
+ + P + D + +AL VLVEG L + +GTYP+VTS
Sbjct: 213 DVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTS 272
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGTV 253
+ T V +GI P + DV V K++ TRVG G FPTE E D L E+G
Sbjct: 273 SNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVT 332
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD------------------------ 289
TGR+RR GW D + RY+ VNG T LA+T LD D
Sbjct: 333 TGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPAN 392
Query: 290 ------------------KEAFGVTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEH 331
+ G ++ LP +A+ ++ +E +GV V + G E
Sbjct: 393 QEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHMGVAVKWVGVGKSRES 452
Query: 332 IIDL 335
+I L
Sbjct: 453 MIQL 456
>sp|Q9Y0Y2|PURA_DROME ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|5052678|gb|AAD38669.1|AF145694_1
(AF145694) BcDNA.LD32788 [Drosophila melanogaster]
Length = 447
Score = 163 bits (409), Expect = 2e-39
Identities = 118/426 (27%), Positives = 185/426 (42%), Gaps = 102/426 (23%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I+ R G NAGH+V NG ++ LP+G +
Sbjct: 28 VVLGAQWGDEGKGKVVDMLA--SDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNE 85
Query: 65 KARLLVGAGVLVDPEVFFHE--------LEHLKEFNVKDRVGIDYRCAIIEEKHKELDRT 116
K ++G GV++ F E L+HL+ +R+ I R ++ + H+ +D
Sbjct: 86 KCVSVIGNGVVIHLPSLFDEVLKNEAKGLQHLE-----NRLIISDRAHLVFDFHQHVDGM 140
Query: 117 NGYLHG--KIGTTGSGCGPANADRVMRKAKQAKDI------------------------- 149
G +GTT G GPA + + R + ++
Sbjct: 141 QEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVATHVRLFPSI 200
Query: 150 ---------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
++ PY+ D ++ AL G +LVEG L + +GTYPYVT
Sbjct: 201 NVDVEAELARYKDYADKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVT 260
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGT 252
S + + V +G+ P + +VI V K++ TRVG GPFPTE + D L E G
Sbjct: 261 SSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEVGV 320
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD-----------KEAFG------- 294
T R+RR GW D + +Y++ VNG T + +T LD D K+ G
Sbjct: 321 TTKRKRRCGWLDIPLLKYTSLVNGYTCICLTKLDILDTLPEIKVAVAYKKPNGEKLDHFP 380
Query: 295 -------------------------VTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPEL 329
V ++ +LP A+ ++ +E + VPV + G
Sbjct: 381 GTIAELGNIEVEYAVLPGWQTSTEEVRNFKELPENAQSYVRLLESELSVPVRWVGVGKGR 440
Query: 330 EHIIDL 335
E II++
Sbjct: 441 ESIINV 446
>gb|AAF55811.1| (AE003732) BcDNA:LD32788 gene product [Drosophila melanogaster]
Length = 447
Score = 163 bits (409), Expect = 2e-39
Identities = 118/426 (27%), Positives = 185/426 (42%), Gaps = 102/426 (23%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I+ R G NAGH+V NG ++ LP+G +
Sbjct: 28 VVLGAQWGDEGKGKVVDMLA--SDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNE 85
Query: 65 KARLLVGAGVLVDPEVFFHE--------LEHLKEFNVKDRVGIDYRCAIIEEKHKELDRT 116
K ++G GV++ F E L+HL+ +R+ I R ++ + H+ +D
Sbjct: 86 KCVSVIGNGVVIHLPSLFDEVLKNEAKGLQHLE-----NRLIISDRAHLVFDFHQHVDGM 140
Query: 117 NGYLHG--KIGTTGSGCGPANADRVMRKAKQAKDI------------------------- 149
G +GTT G GPA + + R + ++
Sbjct: 141 QEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVATHVRLFPSI 200
Query: 150 ---------------KELEPYLTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVT 194
++ PY+ D ++ AL G +LVEG L + +GTYPYVT
Sbjct: 201 NVDVEAELARYKDYADKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVT 260
Query: 195 SKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGT 252
S + + V +G+ P + +VI V K++ TRVG GPFPTE + D L E G
Sbjct: 261 SSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEVGV 320
Query: 253 VTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD-----------KEAFG------- 294
T R+RR GW D + +Y++ VNG T + +T LD D K+ G
Sbjct: 321 TTKRKRRCGWLDIPLLKYTSLVNGYTCICLTKLDILDTLPEIKVAVAYKKPNGEKLDHFP 380
Query: 295 -------------------------VTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPEL 329
V ++ +LP A+ ++ +E + VPV + G
Sbjct: 381 GTIAELGNIEVEYAVLPGWQTSTEEVRNFKELPENAQSYVRFLESELSVPVRWVGVGKGR 440
Query: 330 EHIIDL 335
E II++
Sbjct: 441 ESIINV 446
>pir||AJMSDS adenylosuccinate synthase (EC 6.3.4.4), muscle - mouse
Length = 452
Score = 161 bits (403), Expect = 1e-38
Identities = 112/336 (33%), Positives = 160/336 (47%), Gaps = 53/336 (15%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I++R G NAGH+V ++GK+Y LP+G +
Sbjct: 35 VVLGAQWGDEGKGKVVDLLAT--DADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINT 92
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKD---RVGIDYRCAIIEEKHKELDRTNGYLH 121
KA +G GV++ F E E ++ +KD R+ I R ++ + H+ +D
Sbjct: 93 KAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQR 152
Query: 122 ----GK-IGTTGSGCGPANADRVMRKAKQAKDI--------------------------- 149
GK IGTT G GP + + R + D+
Sbjct: 153 QAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEI 212
Query: 150 -------------KELEPYLTDVAAEINDALD-EGALVLVEGTQGFGLSLYYGTYPYVTS 195
+ + P + D + +AL VLVEG L + +GTYP+VTS
Sbjct: 213 DVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTS 272
Query: 196 KDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYGTV 253
+ T V +GI P + DV V K++ TRVG G FPTE E D L E+G
Sbjct: 273 SNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVT 332
Query: 254 TGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD 289
TGR+RR GW D + RY+ VNG T LA+T LD D
Sbjct: 333 TGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILD 368
>gb|AAF06822.1|AF095282_1 (AF095282) adenylosuccinate synthase [Plasmodium falciparum]
Length = 436
Score = 151 bits (378), Expect = 1e-35
Identities = 117/419 (27%), Positives = 181/419 (42%), Gaps = 94/419 (22%)
Query: 6 VVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQRK 65
++G QWGDEGKG II L+ + + I R G NAGH++ +N KKYA+ LP G +
Sbjct: 13 ILGAQWGDEGKGKIIDMLSEYSD--ITCRFNGGANAGHTISVNDKKYALHLLPCGVLYDN 70
Query: 66 ARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDYRCAIIEEKHKELD---RTNGYLHG 122
++G G+++ + E+E + + DR+ + + I+ + H+ +D T G
Sbjct: 71 NISVLGNGMVIHVKSLMEEIESVGG-KLLDRLYLSNKAHILFDIHQIIDSIQETKKLKEG 129
Query: 123 K-IGTTGSGCGPANADRVMRKAKQAKDIKELEPY-------------------------- 155
K IGTT G GP + + R + +K E +
Sbjct: 130 KQIGTTKRGIGPCYSTKASRIGIRLGTLKNFENFKNMYSKLIDHLMDLYNITEYDKEKEL 189
Query: 156 -------------LTDVAAEINDALDEGALVLVEGTQGFGLSLYYGTYPYVTSKDVTASS 202
+ DV + +N L+ VL+EG L + +GTYPYVTS T
Sbjct: 190 NLFYNYHLKLRDRIVDVISFMNTNLENNKKVLIEGANAAMLDIDFGTYPYVTSSCTTVGG 249
Query: 203 VAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGLV--EYGTVTGRRRRV 260
V + +GI +++ V+ V KS+ TRVG GPF TE+ + L EYGT T R RR
Sbjct: 250 VFSGLGIHHKKLNLVVGVVKSYLTRVGCGPFLTELNNDVGQYLREKGHEYGTTTKRPRRC 309
Query: 261 GWFDFEMARYSARVNGATMLAITMLD---------------------------------- 286
GW D M Y +N M+ +T LD
Sbjct: 310 GWLDIPMLLYVKCINSIEMINLTKLDVLSGLEEILLCVNFKNKKTGELLEKGCYPVEEEI 369
Query: 287 -KYDKEAFG-----------VTDYDKLPRKAKEFIEEIEERVGVPVGLIKTGPELEHII 333
+ D+ +G ++D+LP AK++I IE+ + P+ I GP +++I
Sbjct: 370 SEEDEPVYGKFSGWKEDISTCNEFDELPENAKKYILAIEKYLKTPIVWIGVGPNRKNMI 428
>pir||S21166 adenylosuccinate synthase (EC 6.3.4.4) - human
Length = 455
Score = 145 bits (362), Expect = 7e-34
Identities = 103/338 (30%), Positives = 153/338 (44%), Gaps = 55/338 (16%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I+ R G NAGH+V ++ +Y LP+G +
Sbjct: 31 VVLGAQWGDEGKGKVVDLLA--QDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINP 88
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNV-----KDRVGIDYRCAIIEEKHKELDRTNGY 119
+G GV++ F E E + + R+ I R I+ + H+ D
Sbjct: 89 NVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQ 148
Query: 120 LH----GK-IGTTGSGCGPANADRVMRK---------------------AKQAKDI---- 149
GK +GTT G GP + + R A Q K I
Sbjct: 149 QRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTL 208
Query: 150 --------KELEPYLTDVAAEINDAL--------DEGALVLVEGTQGFGLSLYYGTYPYV 193
++L+ Y+ + + D + +LVEG L + +GTYP+V
Sbjct: 209 EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFV 268
Query: 194 TSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYG 251
TS + T V +G+ P V +V V K++ TRVG G FPTE E + L E+G
Sbjct: 269 TSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFG 328
Query: 252 TVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD 289
TGR+RR GW D + +Y+ +NG T LA+T LD D
Sbjct: 329 VTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILD 366
>gi|4557271 adenylosuccinate synthase; Adenylosuccinate synthetase
(Ade(-)H-complementing) [Homo sapiens]
>gi|1172765|sp|P30520|PURA_HUMAN ADENYLOSUCCINATE
SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)
>gi|415849|emb|CAA47123.1| (X66503) adenylosuccinate
synthetase [Homo sapiens]
Length = 455
Score = 145 bits (362), Expect = 7e-34
Identities = 103/338 (30%), Positives = 153/338 (44%), Gaps = 55/338 (16%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I+ R G NAGH+V ++ +Y LP+G +
Sbjct: 31 VVLGAQWGDEGKGKVVDLLA--QDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINP 88
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNV-----KDRVGIDYRCAIIEEKHKELDRTNGY 119
+G GV++ F E E + + R+ I R I+ + H+ D
Sbjct: 89 NVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQ 148
Query: 120 LH----GK-IGTTGSGCGPANADRVMRK---------------------AKQAKDI---- 149
GK +GTT G GP + + R A Q K I
Sbjct: 149 QRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTL 208
Query: 150 --------KELEPYLTDVAAEINDAL--------DEGALVLVEGTQGFGLSLYYGTYPYV 193
++L+ Y+ + + D + +LVEG L + +GTYP+V
Sbjct: 209 EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFV 268
Query: 194 TSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL--VEYG 251
TS + T V +G+ P V +V V K++ TRVG G FPTE E + L E+G
Sbjct: 269 TSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFG 328
Query: 252 TVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD 289
TGR+RR GW D + +Y+ +NG T LA+T LD D
Sbjct: 329 VTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILD 366
>gi|6671521 adenylosuccinate synthetase 2, non muscle [Mus musculus]
>gi|1172749|sp|P46664|PUA2_MOUSE ADENYLOSUCCINATE
SYNTHETASE, NON-MUSCLE ISOZYME (IMP--ASPARTATE LIGASE)
(ADSS) (AMPSASE) >gi|1083200|pir||A53162
adenylosuccinate synthase (EC 6.3.4.4), non-muscle -
mouse >gi|404057|gb|AAA19727.1| (L24554)
adenylosuccinate synthetase [Mus musculus]
Length = 456
Score = 142 bits (354), Expect = 6e-33
Identities = 115/430 (26%), Positives = 174/430 (39%), Gaps = 105/430 (24%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I+ R G NAGH+V ++ +Y LP+G +
Sbjct: 32 VVLGAQWGDEGKGKVVDLLA--QDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINP 89
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDY---------RCAIIEEKHKELDR 115
+G GV++ F E E NV+ G+D R I+ + H+ D
Sbjct: 90 NVTAFIGNGVVIHLPGLFEEAEK----NVQKGKGLDGWEKRLIISDRAHIVFDFHQAADG 145
Query: 116 TNGYLH----GK-IGTTGSGCGPANADRVMRKAKQAKDI--------------------- 149
GK +GTT G P + + R + D+
Sbjct: 146 IQEQQRQEQAGKNLGTTKKGIRPVYSSKAARSGLRMCDLVSDFDGFSERFKVLTNQYKSI 205
Query: 150 ------------KELEPYLTDVAAEINDAL--------DEGALVLVEGTQGFGLSLYYGT 189
++L+ Y+ + + D + +LVEG L + +GT
Sbjct: 206 YPTLEIDIEGELQQLKGYMERIKPMVKDGVYFLYEALHGPPKKILVEGANAALLDIDFGT 265
Query: 190 YPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL-- 247
YP+VTS + T V +G+ P V +V V K++ TRVG G FPTE E + L
Sbjct: 266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRG 325
Query: 248 VEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLD--------------KYDKEAF 293
E+G TGR+RR GW D +Y+ +NG T LA+T LD K D E
Sbjct: 326 REFGVTTGRKRRCGWLDLVSLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGETI 385
Query: 294 ----------------------------GVTDYDKLPRKAKEFIEEIEERVGVPVGLIKT 325
+ +LP A+ ++ IE+ + +PV I
Sbjct: 386 PHFPANQEVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGV 445
Query: 326 GPELEHIIDL 335
G E +I L
Sbjct: 446 GKSRESMIQL 455
>prf||2122208B adenylosuccinate synthetase:ISOTYPE=nonmuscle [Mus musculus]
Length = 456
Score = 141 bits (352), Expect = 1e-32
Identities = 101/342 (29%), Positives = 151/342 (43%), Gaps = 63/342 (18%)
Query: 5 IVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQR 64
+V+G QWGDEGKG ++ LA + +I+ R G NAGH+V ++ +Y LP+G +
Sbjct: 32 VVLGAQWGDEGKGKVVDLLA--QDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINP 89
Query: 65 KARLLVGAGVLVDPEVFFHELEHLKEFNVKDRVGIDY---------RCAIIEEKHKELDR 115
+G GV++ F E E NV+ G+D R I+ + H+ D
Sbjct: 90 NVTAFIGNGVVIHLPGLFEEAEK----NVQKGKGLDGWEKRLIISDRAHIVFDFHQAADG 145
Query: 116 TNGYLH----GK-IGTTGSGCGPANADRVMRKAKQAKDI--------------------- 149
GK +GTT G P + + R + D+
Sbjct: 146 IQEQQRQEQAGKNLGTTKKGIRPVYSSKAARSGLRMCDLVSDFDGFSERFKVLTNQYKSI 205
Query: 150 ------------KELEPYLTDVAAEINDAL--------DEGALVLVEGTQGFGLSLYYGT 189
++L+ Y+ + + D + +LVEG L + +GT
Sbjct: 206 YPTLEIDIEGELQQLKGYMERIKPMVKDGVYFLYEALHGPPKKILVEGANAALLDIDFGT 265
Query: 190 YPYVTSKDVTASSVAADVGIGPTRVDDVIVVFKSFPTRVGAGPFPTEMPMEEADRLGL-- 247
YP+VTS + T V +G+ P V +V V K++ TRVG G FPTE E + L
Sbjct: 266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRG 325
Query: 248 VEYGTVTGRRRRVGWFDFEMARYSARVNGATMLAITMLDKYD 289
E+G TGR+RR GW D +Y+ +NG T LA+T LD D
Sbjct: 326 REFGVTTGRKRRCGWLDLVSLKYAHMINGFTALALTKLDILD 367
>sp|P96771|PURA_ACTAC ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|1858011|gb|AAC46412.1| (U89525)
adenylosuccinate synthetase [Actinobacillus
actinomycetemcomitans]
Length = 259
Score = 118 bits (293), Expect = 9e-26
Identities = 81/262 (30%), Positives = 120/262 (44%), Gaps = 50/262 (19%)
Query: 10 QWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFMQRKARLL 69
QWGDEGKG I+ L D + + R G AGH++ +NG+K +R +P+G ++ L
Sbjct: 1 QWGDEGKGKIVDLLT--DRVKYVVRYQGGRGAGHTLILNGEKTVLRLIPSGILRDNVTCL 58
Query: 70 VGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELD--RTNGYLHGKIG 125
+G GV++ P E+ L+ NV+DR+ I C +I H +D R + I
Sbjct: 59 IGNGVVLSPAALMQEMSELENRGVNVRDRLLISEACPLILPYHVAMDHAREARWAKRPIR 118
Query: 126 TTGSGCGPANADRVMRKA---------------------------------------KQA 146
TG G GPA D+V R+ K
Sbjct: 119 ATGRGIGPAYEDKVARRGLRVGDLFDRAAFAEKLKNILDYYNFQLVNYYKVEPVDYQKTL 178
Query: 147 KDIKELEPYLTDVAAEINDALD----EGALVLVEGTQGFGLSLYYGTYPYVTSKDVTASS 202
D+ + +T + A+I LD G +L EG QG L + +GTYPYVTS + TA
Sbjct: 179 DDVFAVADIITGMVADITTILDTARKNGDNILFEGAQGTMLDIDHGTYPYVTSSN-TAGG 237
Query: 203 VAADVGIGPTRVDDVIVVFKSF 224
VA+ G GP +D V+ + K++
Sbjct: 238 VASGSGFGPRNLDYVLGIIKAY 259
>sp|O30549|PURA_PSEST ADENYLOSUCCINATE SYNTHETASE (IMP--ASPARTATE LIGASE) (ADSS)
(AMPSASE) >gi|2459965|gb|AAC46134.1| (AF010189) PurA
[Pseudomonas stutzeri]
Length = 174
Score = 104 bits (256), Expect = 2e-21
Identities = 57/151 (37%), Positives = 87/151 (56%), Gaps = 6/151 (3%)
Query: 3 SLIVVGGQWGDEGKGSIIAYLALHDEPEIIARGGVGTNAGHSVFINGKKYAVRQLPTGFM 62
+++V+G QWGDEGKG I+ L D+ + R G NAGH++ I+G+K + +P+G +
Sbjct: 4 NVVVLGTQWGDEGKGKIVDLLT--DQAAAVVRYQGGHNAGHTLVIDGEKTVLHLIPSGIL 61
Query: 63 QRKARLLVGAGVLVDPEVFFHELEHLKE--FNVKDRVGIDYRCAIIEEKHKELD--RTNG 118
+ + L+G GV+V P+ E+ L+E V++R+ I C +I H LD R
Sbjct: 62 RENVQCLIGNGVVVAPDALLREITKLEEKGVPVRERLRISPSCTLILPYHVALDQAREAS 121
Query: 119 YLHGKIGTTGSGCGPANADRVMRKAKQAKDI 149
GKIGTTG G GPA D+V R+ + D+
Sbjct: 122 RSEGKIGTTGRGIGPAYEDKVARRGLRIGDL 152
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.140 0.408
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 133332714
Number of Sequences: 2977
Number of extensions: 5895591
Number of successful extensions: 13621
Number of sequences better than 1.0e-10: 69
Number of HSP's better than 0.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 13242
Number of HSP's gapped (non-prelim): 192
length of query: 339
length of database: 189,106,746
effective HSP length: 55
effective length of query: 284
effective length of database: 156,189,961
effective search space: 44357948924
effective search space used: 44357948924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)