BLASTP 2.0.10 [Aug-26-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= PAB1324 (PAB1324) DE:STOMATIN-LIKE PROTEIN (299 letters) Database: ./suso.pep; /banques/blast2/nr.pep 598,487 sequences; 189,106,746 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value pir||F75003 stomatin-like protein PAB1324 - Pyrococcus abyssi (s... 574 e-163 pir||A71159 probable membrane protein - Pyrococcus horikoshii >g... 536 e-152 pir||E72322 conserved hypothetical protein - Thermotoga maritima... 306 2e-82 sp|O26788|Y692_METTH HYPOTHETICAL PROTEIN MTH692 >gi|7447611|pir... 292 4e-78 pir||D75311 conserved hypothetical protein - Deinococcus radiodu... 244 8e-64 emb|CAB94650.1| (AL359215) putative secreted protein. [Streptomy... 238 4e-62 sp|P71768|YE88_MYCTU HYPOTHETICAL 41.2 KDA PROTEIN RV1488 >gi|74... 236 2e-61 pir||T36857 conserved hypothetical protein SCI5.04c - Streptomyc... 235 4e-61 gb|AAF09169.1|AF065260_1 (AF065260) HflC homolog [Clostridium di... 227 1e-58 gi|10955528 77 pct identical to sp:YBBK_ECOLI[hypothetical 33kd ... 219 2e-56 gb|AAG18899.1| (AE004992) bifunctional short chain isoprenyl dip... 217 1e-55 sp|P77367|YBBK_ECOLI HYPOTHETICAL 33.7 KD PROTEIN IN USHA-TESA I... 215 6e-55 pir||F82256 conserved hypothetical protein VC0976 [imported] - V... 214 1e-54 sp|Q58237|Y827_METJA HYPOTHETICAL PROTEIN MJ0827 >gi|2129105|pir... 206 3e-52 pir||A82838 conserved hypothetical protein XF0185 [imported] - X... 202 4e-51 sp|P72655|YB28_SYNY3 HYPOTHETICAL 35.7 KD PROTEIN SLR1128 >gi|74... 202 4e-51 gb|AAK42367.1| Erythrocyte band 7 membrane protein homolog [Sulf... 196 2e-49 gb|AAF42660.1|AF226511_1 (AF226511) membrane protein GNA1220 [Ne... 192 3e-48 pir||F81107 stomatin/Mec-2 family protein NMB1220 [imported] - N... 192 4e-48 gb|AAF44771.1|AF235154_1 (AF235154) GNA1220 [Neisseria gonorrhoe... 192 4e-48 pir||H81907 probable periplasmic protein NMA1382 [imported] - Ne... 192 5e-48 gb|AAF42676.1|AF226528_1 (AF226528) membrane protein GNA1220 [Ne... 192 5e-48 sp|O59180|YF11_PYRHO HYPOTHETICAL PROTEIN PH1511 >gi|7447604|pir... 191 7e-48 gb|AAC46209.1| (AF002133) MAV266 [Mycobacterium avium] 191 7e-48 gb|AAF42668.1|AF226519_1 (AF226519) membrane protein GNA1220 [Ne... 191 7e-48 pir||B75107 stomatin-like protein PAB1933 - Pyrococcus abyssi (s... 191 9e-48 gb|AAF42663.1|AF226514_1 (AF226514) membrane protein GNA1220 [Ne... 190 1e-47 gb|AAF42675.1|AF226527_1 (AF226527) membrane protein GNA1220 [Ne... 190 2e-47 pir||D72522 probable erythrocyte band 7 integral membrane protei... 190 2e-47 gi|11499015 membrane protein [Archaeoglobus fulgidus] >gi|664798... 189 3e-47 pir||F70378 erythrocyte band 7 homolog - Aquifex aeolicus >gi|29... 183 2e-45 pir||T39599 conserved hypothetical protein SPBC16G5.07c - fissio... 183 3e-45 pir||B71689 hypothetical protein RP328 - Rickettsia prowazekii >... 182 3e-45 gi|7305503 stomatin-like protein 2 [Homo sapiens] >gi|6456118|gb... 179 4e-44 gi|11429564 stomatin-like protein 2 [Homo sapiens] 179 4e-44 pir||A83590 probable stomatin-like protein PA0452 [imported] - P... 178 9e-44 gb|AAF29073.1|AF161458_1 (AF161458) HSPC108 [Homo sapiens] 177 1e-43 gb|AAF47110.1| (AE003462) CG2970 gene product [Drosophila melano... 175 4e-43 pir||T21562 hypothetical protein F30A10.5 - Caenorhabditis elega... 173 2e-42 gb|AAF68388.1|AF236372_1 (AF236372) stomatin-like protein [Zea m... 171 9e-42 pir||T02246 hypothetical protein P1.11659_4 - human >gi|2984585|... 169 3e-41 pir||T18493 hypothetical protein C0800w - malaria parasite (Plas... 168 1e-40 pir||T05863 hypothetical protein T29A15.70 - Arabidopsis thalian... 168 1e-40 dbj|BAA97132.1| (AB018115) contains similarity to stomatin like ... 167 1e-40 pir||G69104 stomatin-like protein - Methanobacterium thermoautot... 161 1e-38 gb|AAC64873.1| (AF034831) stomatin like protein [Rhizobium etli] 159 3e-38 emb|CAC12423.1| (AL445067) membrane protein 7, erythrocyte (huma... 155 7e-37 gb|AAF48927.1| (AE003511) CG7633 gene product [Drosophila melano... 153 2e-36 gb|AAF48928.1| (AE003511) CG7635 gene product [Drosophila melano... 150 2e-35 sp|Q27433|MEC2_CAEEL MECHANOSENSORY PROTEIN 2 >gi|2133486|pir||S... 148 7e-35 emb|CAA73876.1| (Y13473) stomatin [Danio rerio] 147 2e-34 emb|CAB76415.1| (Z66565) contains similarity to Pfam domain: PF0... 146 4e-34 pir||T34691 hypothetical protein SC1B5.13c SC1B5.13c - Streptomy... 145 8e-34 sp|Q19200|STO1_CAEEL STO-1 PROTEIN >gi|7447613|pir||T15971 hypot... 141 7e-33 sp|Q22165|STO4_CAEEL STO-4 PROTEIN 141 9e-33 gb|AAF14646.1|AF163772_6 (AF163772) 7138.6 [Leishmania major] 141 9e-33 gb|AAF54744.1| (AE003694) CG17424 gene product [Drosophila melan... 141 1e-32 sp|Q21190|UNC1_CAEEL UNC-1 PROTEIN >gi|7494583|pir||T34324 eryth... 140 2e-32 pir||T27365 hypothetical protein Y71H9A.2 - Caenorhabditis elega... 140 2e-32 gi|4758276 erythrocyte membrane protein band 7.2 (stomatin) [Hom... 140 2e-32 gb|AAA58432.1| (M81635) stomatin peptide [Homo sapiens] 140 2e-32 gb|AAC50296.1| (U33931) band 7.2b stomatin [Homo sapiens] >gi|15... 140 2e-32 sp|P54116|BAN7_MOUSE ERYTHROCYTE BAND 7 INTEGRAL MEMBRANE PROTEI... 139 5e-32 pir||JC5221 stomatin - mouse >gi|975689|emb|CAA62503.1| (X91043)... 139 5e-32 sp|Q19958|STO2_CAEEL STO-2 PROTEIN >gi|7500297|pir||T16240 hypot... 139 5e-32 gi|7710018 erythrocyte protein band 7.2; protein 7.2b [Mus muscu... 138 8e-32 gb|AAC64173.1| (AF093620) stomatin [Mus musculus] 138 8e-32 sp|Q20657|STO3_CAEEL STO-3 PROTEIN >gi|7503947|pir||T22502 hypot... 130 2e-29 gb|AAF54746.1| (AE003694) CG14736 gene product [Drosophila melan... 122 4e-27 gb|AAF52157.1| (AE003607) CG14644 gene product [Drosophila melan... 113 3e-24 gi|7657615 podocin [Homo sapiens] >gi|7363002|emb|CAB83216.1| (A... 106 4e-22 pir||E82334 hflK protein VC0349 [imported] - Vibrio cholerae (gr... 102 6e-21 sp|P40605|HFLK_VIBPA HFLK PROTEIN >gi|507734|gb|AAA62186.1| (U09... 101 1e-20 gb|AAB18857.1| (U50999) stomatin [Mus musculus] 100 2e-20 pir||B72207 ftsH proteinase activity modulator HflC - Thermotoga... 100 2e-20 pir||A82806 integral membrane proteinase XF0452 [imported] - Xyl... 99 6e-20 sp|P25662|HFLK_ECOLI HFLK PROTEIN >gi|280067|pir||B43653 probabl... 97 2e-19 pir||B83028 proteinase subunit HflK PA4942 [imported] - Pseudomo... 97 2e-19 pir||A72207 ftsH proteinase activity modulator HflK - Thermotoga... 97 3e-19 dbj|BAB06873.1| (AP001517) protease specific for phage lambda cI... 95 8e-19 pir||A71722 hflC protein (hflC) RP123 - Rickettsia prowazekii >g... 94 2e-18 pir||A83028 proteinase subunit HflC PA4941 [imported] - Pseudomo... 92 5e-18 sp|P44546|HFLK_HAEIN HFLK PROTEIN >gi|1075179|pir||A64051 probab... 90 2e-17 gb|AAF47921.1| (AE003481) CG7468 gene product [Drosophila melano... 90 3e-17 sp|O51221|HFLK_BORBU HFLK PROTEIN >gi|7463666|pir||C70125 Lambda... 89 8e-17 sp|P25661|HFLC_ECOLI HFLC PROTEIN >gi|280066|pir||C43653 probabl... 88 1e-16 gi|4759148 stomatin-like protein 1 [Homo sapiens] >gi|4160546|em... 87 3e-16 pir||T32977 unc-24 protein - Caenorhabditis elegans >gi|1353669|... 85 7e-16 sp|P57631|HFLK_BUCAI HFLK PROTEIN >gi|10039224|dbj|BAB13258.1| (... 85 7e-16 emb|CAB52016.1| (AL109665) SLP-1 [Homo sapiens] 84 2e-15 gb|AAF06960.1| (AF156557) stomatin related protein [Homo sapiens... 84 2e-15 pir||B82806 integral membrane proteinase XF0453 [imported] - Xyl... 84 2e-15 gi|11432457 stomatin-like protein 1 [Homo sapiens] 84 2e-15 emb|CAB64583.1| (AL135941) hypothetical protein L391.06 [Leishma... 84 2e-15 sp|P57630|HFLC_BUCAI HFLC PROTEIN >gi|10039223|dbj|BAB13257.1| (... 83 3e-15 sp|O83151|HFLK_TREPA HFLK PROTEIN >gi|7521161|pir||H71364 probab... 83 4e-15 gb|AAF03497.1|AC010676_7 (AC010676) unknown protein [Arabidopsis... 80 2e-14 gb|AAF07389.1|AC010675_12 (AC010675) unknown protein; 58197-5941... 80 3e-14 dbj|BAB06874.1| (AP001517) protease specific for phage lambda cI... 80 4e-14 gb|AAF68390.1|AF236374_1 (AF236374) hypersensitive-induced respo... 79 7e-14 gb|AAF68391.1|AF236375_1 (AF236375) hypersensitive-induced respo... 78 2e-13 gb|AAF68389.1|AF236373_1 (AF236373) hypersensitive-induced respo... 77 3e-13 pir||I39620 hypothetical protein X - Anabaena variabilis (fragme... 76 4e-13 pir||E83340 hypothetical protein PA2438 [imported] - Pseudomonas... 76 6e-13 emb|CAC07434.1| (AJ292360) putative membrane protein [Zea mays] 75 8e-13 dbj|BAB08673.1| (AB018109) gb|AAF03497.1~gene_id:K17N15.12~simil... 73 3e-12 pir||C81445 probable transmembrane protein Cj0268c [imported] - ... 73 4e-12 dbj|BAB10843.1| (AB009053) hypersensitive-induced response prote... 73 5e-12 emb|CAB64584.1| (AL135941) hypothetical protein L391.07 [Leishma... 72 7e-12 sp|P44545|HFLC_HAEIN HFLC PROTEIN >gi|1074959|pir||I64050 probab... 71 2e-11 emb|CAA10289.1| (AJ131049) hypothetical protein [Cicer arietinum] 71 2e-11 gb|AAD42031.1|AF074953_1 (AF074953) stomatin-like protein UNC24 ... 69 6e-11 >pir||F75003 stomatin-like protein PAB1324 - Pyrococcus abyssi (strain Orsay) >gi|5458982|emb|CAB50468.1| (AJ248288) STOMATIN-LIKE PROTEIN [Pyrococcus abyssi] Length = 299 Score = 574 bits (1464), Expect = e-163 Identities = 299/299 (100%), Positives = 299/299 (100%) Query: 1 MMISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV 60 MMISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV Sbjct: 1 MMISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV 60 Query: 61 KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNL 120 KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNL Sbjct: 61 KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNL 120 Query: 121 RAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQM 180 RAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQM Sbjct: 121 RAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQM 180 Query: 181 TAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEAL 240 TAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEAL Sbjct: 181 TAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEAL 240 Query: 241 KMADEKYLTLQYIEKLPDLAKYGNLIVPYDTESLIGLLRVLQKVKSIPLQQSTEKKIEE 299 KMADEKYLTLQYIEKLPDLAKYGNLIVPYDTESLIGLLRVLQKVKSIPLQQSTEKKIEE Sbjct: 241 KMADEKYLTLQYIEKLPDLAKYGNLIVPYDTESLIGLLRVLQKVKSIPLQQSTEKKIEE 299 >pir||A71159 probable membrane protein - Pyrococcus horikoshii >gi|3256875|dbj|BAA29558.1| (AP000002) 298aa long hypothetical membrane protein [Pyrococcus horikoshii] Length = 298 Score = 536 bits (1367), Expect = e-152 Identities = 271/294 (92%), Positives = 287/294 (97%) Query: 2 MISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVK 61 MI AGG+ALIILG+FLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVK Sbjct: 5 MIGAGGIALIILGLFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVK 64 Query: 62 VVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLR 121 +VDLREHVIDVPPQEVICKDNVVVTVDAVVYYQ++DPVKAVYNVSDFLMAIVKLAQTNLR Sbjct: 65 IVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQVIDPVKAVYNVSDFLMAIVKLAQTNLR 124 Query: 122 AIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMT 181 AIIGEMELDETLSGRDIINA+LREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMT Sbjct: 125 AIIGEMELDETLSGRDIINARLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMT 184 Query: 182 AEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALK 241 AEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALK Sbjct: 185 AEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALK 244 Query: 242 MADEKYLTLQYIEKLPDLAKYGNLIVPYDTESLIGLLRVLQKVKSIPLQQSTEK 295 +ADEKYL LQYIEKLP+LA+YGNLIVPYDTESL+GLLR++QK++S P + E+ Sbjct: 245 LADEKYLALQYIEKLPELARYGNLIVPYDTESLVGLLRMIQKIRSTPAGEKKEE 298 >pir||E72322 conserved hypothetical protein - Thermotoga maritima (strain MSB8) >gi|4981401|gb|AAD35948.1|AE001753_4 (AE001753) conserved hypothetical protein [Thermotoga maritima] Length = 305 Score = 306 bits (776), Expect = 2e-82 Identities = 158/292 (54%), Positives = 216/292 (73%), Gaps = 15/292 (5%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 +AL++L FL+++ S++++RPY++GLVERLGKF R + G+HFIIPF ER+ VD+RE Sbjct: 3 IALVVLVFFLIVLAASSIRIVRPYERGLVERLGKFKREVGAGVHFIIPFFERMIKVDMRE 62 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 VIDVPPQEVI +DNVVVTVDAV+YY+I D + VYNVS+F MA +KLAQTNLR +IGE+ Sbjct: 63 KVIDVPPQEVITRDNVVVTVDAVIYYEITDAYRVVYNVSNFEMATIKLAQTNLRNVIGEL 122 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKR 187 ELD+TL+ R+ IN KLR LD+ TD+WGV+ITRVEI++IDPP+DI +AM+KQM AER KR Sbjct: 123 ELDQTLTSRERINMKLRTVLDEATDKWGVRITRVEIKKIDPPQDITDAMSKQMKAERTKR 182 Query: 188 AMILIAEGKKEAAIREAEGQKQAAILKAEGE-----------KQRQILIAEGQAEAIRKV 236 A IL AEG K+A I +AEGQK AAIL+AEGE Q+ IL A GQAEAI+ V Sbjct: 183 AAILEAEGYKQAEILKAEGQKNAAILRAEGEAEAIKRVAEANMQKLILEARGQAEAIKLV 242 Query: 237 LEALKMAD--EKYLTLQYIEKLPDLA--KYGNLIVPYDTESLIGLLRVLQKV 284 A+ + + LT++Y+E L ++A + + +P++ S++ L + ++ Sbjct: 243 FNAIHEGNPTKDLLTVRYLETLKEMANGQATKIFLPFEASSILASLGAISEI 294 >sp|O26788|Y692_METTH HYPOTHETICAL PROTEIN MTH692 >gi|7447611|pir||C69192 stomatin-like protein - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2621777|gb|AAB85197.1| (AE000848) stomatin-like protein [Methanobacterium thermoautotrophicum] Length = 318 Score = 292 bits (739), Expect = 4e-78 Identities = 150/293 (51%), Positives = 209/293 (71%), Gaps = 15/293 (5%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLREHVI 70 +I+ + LL++ S+K++RPY+KG+VERLGK+ R ++ G+ IIPF+E +K VD+RE V+ Sbjct: 5 LIIVLVLLVLAFKSLKILRPYEKGVVERLGKYQRTVESGLVVIIPFIEAIKKVDMREQVV 64 Query: 71 DVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELD 130 DVPPQEVI KDN VV VD V++Y+++DP AVYNV DF AI KLAQTNLR IIG++ELD Sbjct: 65 DVPPQEVITKDNTVVVVDCVIFYEVVDPFNAVYNVVDFYQAITKLAQTNLRNIIGDLELD 124 Query: 131 ETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMI 190 +TL+ R++IN +LRE LD+ TD+WG ++ RVEIQRI+PP DI EAM+KQM AER KRA I Sbjct: 125 QTLTSREMINTQLREVLDEATDKWGTRVVRVEIQRIEPPGDIVEAMSKQMKAERMKRAAI 184 Query: 191 LIAEGKKEAAIREAEGQKQAAILKAEGE-----------KQRQILIAEGQAEAIRKVLEA 239 L AEG K++ I+ AEG KQAAIL+AEG+ K R+I IAEGQA+AI V A Sbjct: 185 LEAEGYKQSEIKRAEGDKQAAILEAEGKAEAIKKVADANKYREIAIAEGQAKAILSVFRA 244 Query: 240 LKMAD--EKYLTLQYIEKLPDLA--KYGNLIVPYDTESLIGLLRVLQKVKSIP 288 + D + L+Y+E L +A + +++P + ++G + + ++ S P Sbjct: 245 MHEGDPTNDIIALKYLEALEKVADGRATKILLPVEATGILGSIAGISEMLSDP 297 >pir||D75311 conserved hypothetical protein - Deinococcus radiodurans (strain R1) >gi|6459936|gb|AAF11687.1|AE002048_7 (AE002048) conserved hypothetical protein [Deinococcus radiodurans] Length = 344 Score = 244 bits (617), Expect = 8e-64 Identities = 132/292 (45%), Positives = 193/292 (65%), Gaps = 15/292 (5%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV-KVVDLR 66 + +++L + ++I LL +K + + ER GKF R L PG++ IIP+++R+ + V++ Sbjct: 5 IFVVVLVLLVIITLLAGIKSVPQGNEWTQERFGKFQRTLKPGLNLIIPYIDRIGRKVNMM 64 Query: 67 EHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGE 126 E V DVP QE+I KDN +VTVDAVV+YQ+LD KA Y V + A++ L TN+R + G Sbjct: 65 EQVFDVPSQEIITKDNALVTVDAVVFYQVLDAAKASYEVRNLEQAVLNLTMTNIRTVTGS 124 Query: 127 MELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREK 186 M+LDE LS RD INAKL +D+ T+ WGVK+TR+E++ I PP D+ +MA+QM AEREK Sbjct: 125 MDLDELLSNRDTINAKLLVVVDEATEPWGVKVTRIEVKDIKPPADLVASMARQMKAEREK 184 Query: 187 RAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQIL-------IAEGQAEAIRKVLEA 239 RA IL AEG ++AAI +A+G+KQAA+LKAEGEKQ + A+ +AEA R V +A Sbjct: 185 RANILDAEGFRQAAILKADGEKQAAVLKAEGEKQASFMESEARERRAQAEAEATRVVSQA 244 Query: 240 LK----MADEKYLTLQYIEKLPDLAKYGN---LIVPYDTESLIGLLRVLQKV 284 + A ++ QY+E L D+A N LI+P + S++G L+ + +V Sbjct: 245 IAGGNVQAVNYFIAQQYVEALRDVASAPNQKTLILPIEATSILGSLQGIAEV 296 >emb|CAB94650.1| (AL359215) putative secreted protein. [Streptomyces coelicolor A3(2)] Length = 343 Score = 238 bits (602), Expect = 4e-62 Identities = 127/302 (42%), Positives = 203/302 (67%), Gaps = 9/302 (2%) Query: 1 MMISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV 60 M SA +A +I+ + + ++ +V+++ + VERLG+++R L PG+ +IP+++RV Sbjct: 3 MEASAFLIAGVIVALLAVFTVVRAVRIVPQARARNVERLGRYHRTLKPGLSVVIPYIDRV 62 Query: 61 -KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTN 119 V+DLRE V+ PQ VI +DN+VV +D V+Y+Q+ DP A Y +++FL A+ +L T Sbjct: 63 YPVIDLREQVVSFKPQPVITEDNLVVEIDTVLYFQVTDPRAAFYEIANFLQAVEQLTVTT 122 Query: 120 LRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQ 179 LR ++G M+L++TL+ RD IN++LR LD+ T +WG+++ RVEI+ IDPP+ I++AM KQ Sbjct: 123 LRNVVGSMDLEKTLTSRDTINSQLRGVLDEATGKWGLRVNRVEIKAIDPPQSIKDAMQKQ 182 Query: 180 MTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEA 239 M AER+KRA IL AEG++++ I AEG KQAA+L+AEG + +IL AEGQ+ AI +V +A Sbjct: 183 MRAERDKRAAILGAEGQRQSQILTAEGDKQAAVLRAEGNRTAEILKAEGQSRAIDEVFQA 242 Query: 240 LKM--ADEKYLTLQYIEKLPDLAKYGN---LIVPYD-TESLIGLLRVLQKVKSIPLQQST 293 + D K L QY++ LP LA+ ++P + T +L G+ R +++P +T Sbjct: 243 VHRNDPDPKLLAYQYLQVLPQLAQGSGSTFWVIPSEVTSALQGVSRAF--TEALPQSPAT 300 Query: 294 EK 295 + Sbjct: 301 RE 302 >sp|P71768|YE88_MYCTU HYPOTHETICAL 41.2 KDA PROTEIN RV1488 >gi|7476783|pir||C70711 hypothetical protein Rv1488 - Mycobacterium tuberculosis (strain H37RV) >gi|1524234|emb|CAB02038.1| (Z79701) hypothetical protein Rv1488 [Mycobacterium tuberculosis] Length = 381 Score = 236 bits (597), Expect = 2e-61 Identities = 135/309 (43%), Positives = 196/309 (62%), Gaps = 31/309 (10%) Query: 5 AGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKV-V 63 AG V L +L IF +I++ SV +I + ++ERLG+++R + + ++PF++RV+ V Sbjct: 6 AGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTVSGQLTLLVPFIDRVRARV 65 Query: 64 DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAI 123 DLRE V+ PPQ VI +DN+ + +D VVY+Q+ P AVY +S++++ + +L T LR + Sbjct: 66 DLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAVYEISNYIVGVEQLTTTTLRNV 125 Query: 124 IGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAE 183 +G M L++TL+ RD INA+LR LD+ T RWG+++ RVE++ IDPP IQ +M KQM A+ Sbjct: 126 VGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARVELRSIDPPPSIQASMEKQMKAD 185 Query: 184 REKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAE---------------- 227 REKRAMIL AEG +EAAI++AEGQKQA IL AEG KQ IL AE Sbjct: 186 REKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRMLRAQGERAA 245 Query: 228 ------GQAEAIRKVLEALKMA--DEKYLTLQYIEKLPDLAKYGNL----IVPYD-TESL 274 GQA+AI K A+K + L QY++ LP++A+ G+ +VP D +L Sbjct: 246 AYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPEMAR-GDANKVWVVPSDFNAAL 304 Query: 275 IGLLRVLQK 283 G R+L K Sbjct: 305 QGFTRLLGK 313 >pir||T36857 conserved hypothetical protein SCI5.04c - Streptomyces coelicolor >gi|5123532|emb|CAB45288.1| (AL079332) conserved hypothetical protein [Streptomyces coelicolor A3(2)] Length = 319 Score = 235 bits (594), Expect = 4e-61 Identities = 116/257 (45%), Positives = 179/257 (69%), Gaps = 3/257 (1%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKV-VDLR 66 + LIIL + + I L+ +++VI +VER G++ R L+ G++ ++PF++ ++ +DLR Sbjct: 6 IVLIILVVLVFIALIKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDTIRNRIDLR 65 Query: 67 EHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGE 126 E V+ PPQ VI +DN+VV +D V+YYQ+ D A Y V+ ++ AI +L T LR IIG Sbjct: 66 EQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGG 125 Query: 127 MELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREK 186 M+L+ TL+ R+ INA LR LD+ T +WG+++ RVE++ I+PP IQ++M KQM A+R+K Sbjct: 126 MDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDK 185 Query: 187 RAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMA--D 244 RA IL AEG +++ I AEG+KQ+ IL+AEGE + L AEG+A+A+R V EA+ D Sbjct: 186 RAAILQAEGVRQSEILRAEGEKQSQILRAEGEAKAAALRAEGEAQAVRTVFEAIHAGDPD 245 Query: 245 EKYLTLQYIEKLPDLAK 261 +K L+ QY++ LP +A+ Sbjct: 246 QKLLSYQYLQMLPKIAE 262 >gb|AAF09169.1|AF065260_1 (AF065260) HflC homolog [Clostridium difficile] Length = 320 Score = 227 bits (573), Expect = 1e-58 Identities = 132/315 (41%), Positives = 192/315 (60%), Gaps = 46/315 (14%) Query: 11 IILGIFLLIML----LLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVK-VVDL 65 I+L I L++++ L ++VI+ + G++ RLGKF ++ + G+HF+IPF++++ V+DL Sbjct: 5 IVLSIVLIVVVVAISLTCIRVIKQSKVGIIMRLGKFQKVAETGVHFLIPFLDKMAYVIDL 64 Query: 66 REHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIG 125 RE VID PPQ VI KDNV + +D VVYY++ DPV+ V+ +++ + AI L T LR IIG Sbjct: 65 REIVIDFPPQPVITKDNVTMQIDTVVYYKVTDPVRYVFEIANPIAAIENLTATTLRNIIG 124 Query: 126 EMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAERE 185 E++LDETL+ + K D+ TD+WG+K+ RVE++ I PP+DIQ AM KQM AERE Sbjct: 125 ELDLDETLTSQRYNKCKNENYPDEATDKWGIKVNRVELKNIMPPQDIQVAMEKQMRAERE 184 Query: 186 KRAMILIAEGKKEAAIREAEGQKQAAILK-----------AEGEKQRQILIAEGQAEAIR 234 +R IL AEG K AAI +AEG+KQ+AIL AEGEK+ IL+AEG+AEAIR Sbjct: 185 RREAILQAEGNKSAAILQAEGEKQSAILTAEAKKEAMVRVAEGEKESAILVAEGEAEAIR 244 Query: 235 K--------------------------VLEALKMA--DEKYLTLQYIEKLPDLA--KYGN 264 + V A+K A D L L+ +E L +A K Sbjct: 245 QTAIAKAQGEAEMIKRTQMATAEGLKLVFSAMKEADIDNNILALKSMEALEKMAEGKSTK 304 Query: 265 LIVPYDTESLIGLLR 279 L++P + + +G + Sbjct: 305 LVLPSEAVNFLGTFK 319 >gi|10955528 77 pct identical to sp:YBBK_ECOLI[hypothetical 33kd protein of E. coli] [Escherichia coli] >gi|9971722|dbj|BAB12673.1| (AP002527) 77 pct identical to sp:YBBK_ECOLI[hypothetical 33kd protein of E. coli] [Escherichia coli] Length = 325 Score = 219 bits (553), Expect = 2e-56 Identities = 122/296 (41%), Positives = 184/296 (61%), Gaps = 19/296 (6%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV-KVVDLR 66 + L++L + LI + +VK++ VER GK+ L PG+HF+IPFM+R+ + +++ Sbjct: 13 IPLLLLILVALIFVKSAVKIVPQGNAWTVERFGKYTHTLSPGLHFLIPFMDRIGQRINMM 72 Query: 67 EHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGE 126 E V+DVP QEVI KDN VT+DAV + Q++D KA Y V + AI L TN+R ++G Sbjct: 73 ETVLDVPKQEVISKDNANVTIDAVCFIQVIDAAKAAYEVDNLASAISNLVMTNIRTVVGG 132 Query: 127 MELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREK 186 M LD+ LS RD IN+KL +D TD WG+K+TR+EI+ + PP+++ +AM QM AER K Sbjct: 133 MNLDDMLSQRDSINSKLLTVVDYATDPWGIKVTRIEIRDVKPPEELTKAMNAQMKAERTK 192 Query: 187 RAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQIL-------IAEGQAEAIRKVLEA 239 RA IL AEG +++ I +AEG+KQ+ ILKAEGE+Q L AE +A A + V +A Sbjct: 193 RAQILEAEGIRQSQILKAEGEKQSQILKAEGERQSAFLQSEARERQAEAEARATKLVSDA 252 Query: 240 LKMADEK----YLTLQYIEKLPDLAKYGN---LIVPYDTESLI----GLLRVLQKV 284 + D + ++ +Y E L + N +++P D+ SL+ G+ +L+ V Sbjct: 253 IAEGDVQSVNYFIAQKYTEALQAIGTASNSKLVMMPLDSSSLVSSVAGISELLKNV 308 >gb|AAG18899.1| (AE004992) bifunctional short chain isoprenyl diphosphate synthase; Ids [Halobacterium sp. NRC-1] Length = 392 Score = 217 bits (547), Expect = 1e-55 Identities = 113/279 (40%), Positives = 182/279 (64%), Gaps = 10/279 (3%) Query: 6 GGVALIILGIFLLIMLLL----SVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVK 61 GG ++G+ LL++L + +V+++ Y+K + G++ LL+PGI+ I PF+ R Sbjct: 24 GGSLTTVVGLLLLVLLAVVVYETVQIVDAYEKQALTVFGEYRGLLEPGINVIPPFVSRTY 83 Query: 62 VVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLR 121 D+R IDVP QE I +DN VT DAVVY ++ D +A V D+ A+ LAQT LR Sbjct: 84 TFDMRTQTIDVPRQEAITRDNSPVTADAVVYIRVRDAKRAFLEVDDYKTAVSNLAQTTLR 143 Query: 122 AIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMT 181 A++G+MELD+TL+ R IN+++R ELD+ TD WG+++ VE++ ++P +++Q+AM +Q + Sbjct: 144 AVLGDMELDDTLNKRQEINSRIRTELDEPTDEWGIRVESVEVREVNPSQEVQQAMEQQTS 203 Query: 182 AEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEA-- 239 AER +RAMIL A+G++++AI A+G KQ+ I++A+GEKQ QIL E Q +AI VL A Sbjct: 204 AERRRRAMILEAQGERQSAIENAQGDKQSNIIRAQGEKQSQIL--EAQGDAISTVLRAKS 261 Query: 240 LKMADEKYLTLQYIEKLPDL--AKYGNLIVPYDTESLIG 276 + E+ + + +E L + + ++P + SL+G Sbjct: 262 AESMGERAIIEKGMETLEGIGEGESNTFVLPQEVTSLVG 300 >sp|P77367|YBBK_ECOLI HYPOTHETICAL 33.7 KD PROTEIN IN USHA-TESA INTERGENIC REGION >gi|7447609|pir||H64779 probable membrane protein ybbK - Escherichia coli >gi|1773171|gb|AAB40243.1| (U82664) similar to M. tuberculosis MTCY277.09 [Escherichia coli] >gi|1786697|gb|AAC73591.1| (AE000155) putative protease [Escherichia coli K12] Length = 305 Score = 215 bits (541), Expect = 6e-55 Identities = 115/285 (40%), Positives = 179/285 (62%), Gaps = 18/285 (6%) Query: 10 LIILGIFLLIMLLL---SVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV-KVVDL 65 LI + I + + L++ VK++ + VER G++ + L PG+ ++PFM+R+ + +++ Sbjct: 2 LIFIPILIFVALVIVGAGVKIVPQGYQWTVERFGRYTKTLQPGLSLVVPFMDRIGRKINM 61 Query: 66 REHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIG 125 E V+D+P QEVI KDN VT+DAV + Q++D +A Y VS+ +AI+ L TN+R ++G Sbjct: 62 MEQVLDIPSQEVISKDNANVTIDAVCFIQVIDAPRAAYEVSNLELAIINLTMTNIRTVLG 121 Query: 126 EMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAERE 185 MELDE LS RD IN++L +D+ T+ WG+K+TR+EI+ + PP ++ +M QM AER Sbjct: 122 SMELDEMLSQRDSINSRLLRIVDEATNPWGIKVTRIEIRDVRPPAELISSMNAQMKAERT 181 Query: 186 KRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQIL-------IAEGQAEAIRKVLE 238 KRA IL AEG ++A I +AEG+KQ+ ILKAEGE+Q L AE +A A + V E Sbjct: 182 KRAYILEAEGIRQAEILKAEGEKQSQILKAEGERQSAFLQAEARERSAEAEARATKMVSE 241 Query: 239 ALKMAD----EKYLTLQYIEKLPDLAKYGN---LIVPYDTESLIG 276 A+ D ++ +Y E L + N +++P + SL+G Sbjct: 242 AIASGDIQAVNYFVAQKYTEALQQIGSSSNSKVVMMPLEASSLMG 286 >pir||F82256 conserved hypothetical protein VC0976 [imported] - Vibrio cholerae (group O1 strain N16961) >gi|9655437|gb|AAF94138.1| (AE004179) conserved hypothetical protein [Vibrio cholerae] Length = 306 Score = 214 bits (539), Expect = 1e-54 Identities = 120/284 (42%), Positives = 172/284 (60%), Gaps = 15/284 (5%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV-KVVDLR 66 + + +L + ++I + +VK + VER G++ + L PG++ IIPF++RV +++ Sbjct: 7 ITIAVLVLAVVIFISSAVKTVPQGNNWTVERFGRYTQTLKPGLNLIIPFIDRVGHKINMM 66 Query: 67 EHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGE 126 E V+D+P QEVI KDN V +DAV + Q++D KA Y VS AI L TN+R ++G Sbjct: 67 EQVLDIPAQEVISKDNANVVIDAVCFVQVIDAAKAAYEVSQLQHAIRNLTLTNMRTVLGS 126 Query: 127 MELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREK 186 MELDE LS RD+IN KL +D T WGVK+TR+EI+ + PP D+ AM QM AER K Sbjct: 127 MELDEMLSQRDMINTKLLSIVDHATSPWGVKVTRIEIKDVQPPADLTAAMNAQMKAERNK 186 Query: 187 RAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQIL-------IAEGQAEAIRKVLEA 239 RA +L AEG ++A I AEGQKQ+ ILKAEGEKQ IL AE +A+A V EA Sbjct: 187 RAEVLEAEGVRQAQILRAEGQKQSEILKAEGEKQAAILQAEARERAAEAEAKATTMVSEA 246 Query: 240 LKMADEK----YLTLQYIEKLPDLAKYGN---LIVPYDTESLIG 276 + D + ++ Y E L + + N +++P + L+G Sbjct: 247 IAKGDMQAVNYFIAQGYTEALKAIGQAENGKIIMLPLEATGLMG 290 >sp|Q58237|Y827_METJA HYPOTHETICAL PROTEIN MJ0827 >gi|2129105|pir||C64403 membrane protein homolog - Methanococcus jannaschii >gi|1591514|gb|AAB98826.1| (U67526) membrane protein, putative regulator of cation conductance [Methanococcus jannaschii] Length = 199 Score = 206 bits (518), Expect = 3e-52 Identities = 103/187 (55%), Positives = 138/187 (73%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLREHVI 70 +ILGI L +++ ++ ++ Y+ GL+ RLG+ L PGI+ IIPF++ VD+R V Sbjct: 11 LILGIIALFIIVKAIVIVNQYEGGLIFRLGRVIGKLKPGINIIIPFLDVPVKVDMRTRVT 70 Query: 71 DVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELD 130 D+PPQE+I KDN VV VDAVVYY+++D KA+ V D+ AI+ LAQT LRAIIG MELD Sbjct: 71 DIPPQEMITKDNAVVKVDAVVYYRVIDVEKAILEVEDYEYAIINLAQTTLRAIIGSMELD 130 Query: 131 ETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMI 190 E L+ R+ IN+KL E LD+ TD WGV+I +VE++ IDPP+DI+ AMA+QM AER KRA I Sbjct: 131 EVLNKREYINSKLLEILDRETDAWGVRIEKVEVKEIDPPEDIKNAMAQQMKAERLKRAAI 190 Query: 191 LIAEGKK 197 L AEG+K Sbjct: 191 LEAEGEK 197 >pir||A82838 conserved hypothetical protein XF0185 [imported] - Xylella fastidiosa (strain 9a5c) >gi|9104984|gb|AAF82998.1|AE003872_9 (AE003872) conserved hypothetical protein [Xylella fastidiosa] Length = 337 Score = 202 bits (509), Expect = 4e-51 Identities = 111/290 (38%), Positives = 183/290 (62%), Gaps = 16/290 (5%) Query: 2 MISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV- 60 M+ +ALI+L + +I+L SV ++ + VE+ G++ + PG+HF+IP + V Sbjct: 20 MLPNNVLALIVL-VAGVILLFKSVIMVPQGYEWTVEKFGRYTDTMKPGLHFLIPLIYSVG 78 Query: 61 KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNL 120 + V + E V+ VP QEVI KDN V VD VV++Q+LD KA Y V++ +A++ L QTN+ Sbjct: 79 RKVSMMEQVLAVPSQEVITKDNAGVRVDGVVFFQVLDAAKAAYEVANLEIAMIALVQTNI 138 Query: 121 RAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQM 180 R ++G ++ DE+LS R+ INAKL ++ T WGVK+TR++I+ I PP ++ E+M +Q Sbjct: 139 RTVVGSIDFDESLSQRETINAKLLSVVEHATSPWGVKVTRIDIKDIQPPHNLAESMQQQK 198 Query: 181 TAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQI-------LIAEGQAEAI 233 AE+ +RA IL AEG +++AI A+G+KQAA+++AEG K+ +AE +A+A Sbjct: 199 MAEQTRRATILEAEGVRQSAILRADGEKQAAVMEAEGRKEAAFRDAEARERLAEAEAKAT 258 Query: 234 RKVLEALKMADEK----YLTLQYIEKLPDLAKYGN---LIVPYDTESLIG 276 R + EA+ + + ++ +Y+E +LA N +++P +T +IG Sbjct: 259 RILSEAISQGNVQAVNYFVAQKYVEAFKELATAPNQKFILMPMETSGIIG 308 >sp|P72655|YB28_SYNY3 HYPOTHETICAL 35.7 KD PROTEIN SLR1128 >gi|7447608|pir||S74505 erthyrocyte band 7 integral membrane protein - Synechocystis sp. (strain PCC 6803) >gi|1651729|dbj|BAA16657.1| (D90899) erthyrocyte band 7 integral membrane protein, protein 7.2B, stomatin [Synechocystis sp.] Length = 321 Score = 202 bits (509), Expect = 4e-51 Identities = 109/222 (49%), Positives = 151/222 (67%), Gaps = 3/222 (1%) Query: 24 SVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDL-REHVIDVPPQEVICKDN 82 SVK++ + LVERLG +N+ L PG++F +P ++RV RE VID+PPQ I KDN Sbjct: 19 SVKIVNEKNEYLVERLGSYNKKLTPGLNFTVPILDRVVFKQTTREKVIDIPPQSCITKDN 78 Query: 83 VVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAK 142 V +T DAVVY++I+D KA Y V + A+V L T +R+ IG++ELD+T + R IN Sbjct: 79 VAITADAVVYWRIIDMEKAYYKVENLQSAMVNLVLTQIRSEIGKLELDQTFTARTEINEL 138 Query: 143 LREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIR 202 L ELD TD WGVK+TRVE++ I P K + ++M QMTAER+KRA IL +EG++++AI Sbjct: 139 LLRELDISTDPWGVKVTRVELRDIMPSKAVLDSMELQMTAERKKRAAILTSEGQRDSAIN 198 Query: 203 EAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMAD 244 A+G QA +L+AE +K+ IL AE AE +KVLEA A+ Sbjct: 199 SAQGDAQARVLEAEAKKKAAILNAE--AEQQKKVLEAKATAE 238 >gb|AAK42367.1| Erythrocyte band 7 membrane protein homolog [Sulfolobus solfataricus] Length = 267 Score = 196 bits (494), Expect = 2e-49 Identities = 97/201 (48%), Positives = 150/201 (74%), Gaps = 1/201 (0%) Query: 1 MMISAGG-VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMER 59 M IS G V ++ L I ++I + +S +V+R +++ +V RLG+F R+ PGI F+IPF++R Sbjct: 1 MAISIGDIVGIVFLIIIIIIFIAMSFRVVREWERAVVLRLGRFLRVKGPGIIFLIPFVDR 60 Query: 60 VKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTN 119 VVDLR + ++VPPQ ++ KDNV V+VDAVVYY+++DP KAV +V ++ +A++ LAQT+ Sbjct: 61 PLVVDLRVNTVEVPPQTILTKDNVTVSVDAVVYYKVVDPQKAVLSVFNYNVAVLNLAQTS 120 Query: 120 LRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQ 179 LR I+G+MELDE LS R+ IN +++E LD T+ WG+K+T V I+ I +D+ AMAKQ Sbjct: 121 LRDIVGQMELDELLSKREEINKRIQEILDVTTEGWGIKVTAVTIRDIRLSQDLLSAMAKQ 180 Query: 180 MTAEREKRAMILIAEGKKEAA 200 AER +RA ++++EG+++AA Sbjct: 181 AEAERLRRAKVILSEGERQAA 201 >gb|AAF42660.1|AF226511_1 (AF226511) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228856|gb|AAF42662.1|AF226513_1 (AF226513) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228860|gb|AAF42664.1|AF226515_1 (AF226515) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228864|gb|AAF42666.1|AF226517_1 (AF226517) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228866|gb|AAF42667.1|AF226518_1 (AF226518) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228871|gb|AAF42669.1|AF226521_1 (AF226521) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228875|gb|AAF42671.1|AF226523_1 (AF226523) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228891|gb|AAF42679.1|AF226531_1 (AF226531) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228901|gb|AAF42684.1|AF226536_1 (AF226536) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228903|gb|AAF42685.1|AF226537_1 (AF226537) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228907|gb|AAF42687.1|AF226539_1 (AF226539) membrane protein GNA1220 [Neisseria meningitidis] Length = 315 Score = 192 bits (484), Expect = 3e-48 Identities = 121/303 (39%), Positives = 179/303 (58%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL + + + S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I +M Q+TAEREKRA Sbjct: 125 DKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >pir||F81107 stomatin/Mec-2 family protein NMB1220 [imported] - Neisseria meningitidis (group B strain MD58) >gi|7226459|gb|AAF41602.1| (AE002470) stomatin/Mec-2 family protein [Neisseria meningitidis MC58] >gi|7228873|gb|AAF42670.1|AF226522_1 (AF226522) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228877|gb|AAF42672.1|AF226524_1 (AF226524) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228879|gb|AAF42673.1|AF226525_1 (AF226525) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228881|gb|AAF42674.1|AF226526_1 (AF226526) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228887|gb|AAF42677.1|AF226529_1 (AF226529) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228889|gb|AAF42678.1|AF226530_1 (AF226530) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228893|gb|AAF42680.1|AF226532_1 (AF226532) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228899|gb|AAF42683.1|AF226535_1 (AF226535) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228905|gb|AAF42686.1|AF226538_1 (AF226538) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228909|gb|AAF42688.1|AF226540_1 (AF226540) membrane protein GNA1220 [Neisseria meningitidis] Length = 315 Score = 192 bits (483), Expect = 4e-48 Identities = 121/303 (39%), Positives = 179/303 (58%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL + + + S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I +M Q+TAEREKRA Sbjct: 125 DKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >gb|AAF44771.1|AF235154_1 (AF235154) GNA1220 [Neisseria gonorrhoeae] >gi|7274434|gb|AAF44772.1|AF235155_1 (AF235155) GNA1220 [Neisseria gonorrhoeae] >gi|7274436|gb|AAF44773.1|AF235156_1 (AF235156) GNA1220 [Neisseria gonorrhoeae] Length = 315 Score = 192 bits (483), Expect = 4e-48 Identities = 122/303 (40%), Positives = 178/303 (58%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL + + S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I AM Q+TAEREKRA Sbjct: 125 DKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRAMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >pir||H81907 probable periplasmic protein NMA1382 [imported] - Neisseria meningitidis (group A strain Z2491) >gi|7228854|gb|AAF42661.1|AF226512_1 (AF226512) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228911|gb|AAF42689.1|AF226541_1 (AF226541) membrane protein GNA1220 [Neisseria meningitidis] >gi|7380050|emb|CAB84628.1| (AL162755) putative periplasmic protein [Neisseria meningitidis Z2491] Length = 315 Score = 192 bits (482), Expect = 5e-48 Identities = 121/303 (39%), Positives = 179/303 (58%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL +++ S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLAAVVVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I +M Q+TAEREKRA Sbjct: 125 DKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >gb|AAF42676.1|AF226528_1 (AF226528) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228895|gb|AAF42681.1|AF226533_1 (AF226533) membrane protein GNA1220 [Neisseria meningitidis] Length = 315 Score = 192 bits (482), Expect = 5e-48 Identities = 121/303 (39%), Positives = 179/303 (58%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL + + + S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I +M Q+TAEREKRA Sbjct: 125 DKTFEERDEINSIVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >sp|O59180|YF11_PYRHO HYPOTHETICAL PROTEIN PH1511 >gi|7447604|pir||C71027 probable erythrocyte band7 integral membrane protein - Pyrococcus horikoshii >gi|3257936|dbj|BAA30619.1| (AP000006) 266aa long hypothetical erythrocyte band7 integral membrane protein [Pyrococcus horikoshii] Length = 266 Score = 191 bits (481), Expect = 7e-48 Identities = 94/206 (45%), Positives = 145/206 (69%), Gaps = 2/206 (0%) Query: 1 MMISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV 60 MM + I+ +F+LI L ++K+++ Y++ ++ RLG+ PG+ FIIP E+ Sbjct: 1 MMFATNFFVTSIILLFILIFLASAIKIVKEYERAVIFRLGRVVGARGPGLFFIIPIFEKA 60 Query: 61 KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNL 120 +VDLR V+DVP QE I KDNV V V+AVVY++++DPVKAV V +++MA +++QT L Sbjct: 61 VIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTL 120 Query: 121 RAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQM 180 R++IG+ LDE LS RD +N +L+ +D+ TD WG+K+T VEI+ ++ P +Q+AMA+Q Sbjct: 121 RSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQA 180 Query: 181 TAEREKRAMILIAEGKKEAA--IREA 204 AERE+RA I +AE +++AA +REA Sbjct: 181 EAERERRARITLAEAERQAAEKLREA 206 >gb|AAC46209.1| (AF002133) MAV266 [Mycobacterium avium] Length = 266 Score = 191 bits (481), Expect = 7e-48 Identities = 90/206 (43%), Positives = 144/206 (69%), Gaps = 1/206 (0%) Query: 5 AGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKV-V 63 AG V L +L IF ++++ SV +I + ++ERLG+++R + + ++PF++R++ V Sbjct: 6 AGLVLLAVLVIFAIVVVAKSVALIPLAEAAVIERLGRYSRTVSGSVTLLVPFIDRIRARV 65 Query: 64 DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAI 123 DLRE V+ PPQ VI +DN+ + +D VVY+Q+ P AVY +S++++ + +L T +R + Sbjct: 66 DLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAVYEISNYIVGVEQLTTTTVRNV 125 Query: 124 IGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAE 183 +G M L++TL+ RD IN +LR LD+ T RWG+++ RVE++ IDPP IQ +M KQM A+ Sbjct: 126 VGGMTLEQTLTSRDQINGQLRGVLDEATGRWGLRVARVELRSIDPPPSIQASMEKQMKAD 185 Query: 184 REKRAMILIAEGKKEAAIREAEGQKQ 209 REKRAMIL AEG +E+AI+E + + Sbjct: 186 REKRAMILTAEGSRESAIKEPRARSR 211 >gb|AAF42668.1|AF226519_1 (AF226519) membrane protein GNA1220 [Neisseria meningitidis] Length = 315 Score = 191 bits (481), Expect = 7e-48 Identities = 121/303 (39%), Positives = 179/303 (58%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL +++ S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLAAVVVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I +M Q+TAEREKRA Sbjct: 125 DKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >pir||B75107 stomatin-like protein PAB1933 - Pyrococcus abyssi (strain Orsay) >gi|5458082|emb|CAB49571.1| (AJ248285) STOMATIN-LIKE PROTEIN [Pyrococcus abyssi] Length = 268 Score = 191 bits (480), Expect = 9e-48 Identities = 96/199 (48%), Positives = 143/199 (71%), Gaps = 3/199 (1%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 V IIL +F+LI L ++K+++ Y++ ++ RLG+ PG+ FIIP E+ +VDLR Sbjct: 9 VTTIIL-LFILIFLASAIKIVKEYERAVIFRLGRVVGARGPGLFFIIPIFEKAVIVDLRT 67 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 V+DVP QE I KDNV V V+AVVY++++DPVKAV V +++MA +++QT LR++IG+ Sbjct: 68 QVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQA 127 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKR 187 LDE LS RD +N +L+ +D+ TD WG+K+T VEI+ ++ P +Q AMAKQ AERE+R Sbjct: 128 HLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQRAMAKQAEAERERR 187 Query: 188 AMILIAEGKKEAA--IREA 204 A I +AE +++AA +REA Sbjct: 188 ARITLAEAERQAAEKLREA 206 >gb|AAF42663.1|AF226514_1 (AF226514) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228862|gb|AAF42665.1|AF226516_1 (AF226516) membrane protein GNA1220 [Neisseria meningitidis] >gi|7228897|gb|AAF42682.1|AF226534_1 (AF226534) membrane protein GNA1220 [Neisseria meningitidis] Length = 315 Score = 190 bits (479), Expect = 1e-47 Identities = 121/303 (39%), Positives = 178/303 (57%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL + + S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I +M Q+TAEREKRA Sbjct: 125 DKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >gb|AAF42675.1|AF226527_1 (AF226527) membrane protein GNA1220 [Neisseria meningitidis] Length = 315 Score = 190 bits (478), Expect = 2e-47 Identities = 121/303 (39%), Positives = 178/303 (57%), Gaps = 29/303 (9%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHV 69 IIL + + S VI + +VERLG+F+R L G++ +IPF++RV L+E Sbjct: 5 IILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIP 64 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 +DVP Q I +DN +TVD ++Y+Q+ DP A Y S+++MAI +LAQT LR++IG MEL Sbjct: 65 LDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMEL 124 Query: 130 DETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAM 189 D+T RD IN+ + LD+ WGVK+ R EI+ + PP++I +M Q+TAEREKRA Sbjct: 125 DKTFEERDEINSIVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRAR 184 Query: 190 ILIAEGKK-----------EAAIREAEGQKQAA-----------ILKAEGEKQRQILIAE 227 I +EG+K EA I+++EG+ QAA I +A+GE + L+AE Sbjct: 185 IAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAE 244 Query: 228 GQAEAIRKVLEALKM---ADEKYLTL--QYIEKLPDLAKYGN-LIVPYDTESLIGLLRVL 281 AEAIR++ AL+ AD L + QY+ +LAK N LI+P + + L+ Sbjct: 245 ANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAG 304 Query: 282 QKV 284 K+ Sbjct: 305 MKI 307 >pir||D72522 probable erythrocyte band 7 integral membrane protein APE2153 - Aeropyrum pernix (strain K1) >gi|5105852|dbj|BAA81164.1| (AP000063) 278aa long hypothetical erythrocyte band 7 integral membrane protein [Aeropyrum pernix] Length = 278 Score = 190 bits (477), Expect = 2e-47 Identities = 115/279 (41%), Positives = 169/279 (60%), Gaps = 38/279 (13%) Query: 7 GVALIILGIFLLIMLLL---SVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV 63 G ALI +G+ LLI+L+L S+K++R Y++ ++ RLG+ + PG+ IIPF++ + V Sbjct: 18 GQALIPVGVALLIVLILLSMSIKIVREYERAVIFRLGRLIGVKGPGLFLIIPFVDTLVKV 77 Query: 64 DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAI 123 DLR +D+P Q I KDNV V VDAVVYY++ DP KAV + ++ A+V LAQT LR + Sbjct: 78 DLRIVTVDIPEQRTITKDNVTVGVDAVVYYKVFDPEKAVVRIENYHYAVVMLAQTTLRDV 137 Query: 124 IGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAE 183 IG++ELD+ L+ R+ IN KL+E LD++TD WG+K+T V I+ + P+ + AMAKQ AE Sbjct: 138 IGQVELDDLLTKREEINKKLQEILDQLTDPWGIKVTAVTIKEVKLPESMLRAMAKQAEAE 197 Query: 184 REKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMA 243 R +RA I+ EAEG++QAA + AE AE K AL+ Sbjct: 198 RWRRARII-----------EAEGERQAAKIMAEA------------AEFYEKHPAALR-- 232 Query: 244 DEKYLTLQYIEKLPDLAKYGNLIV----PYDTESLIGLL 278 L+ ++ L ++AK NL+V E +IGL+ Sbjct: 233 ------LRELQTLIEVAKEKNLVVVTPLRMGAEDMIGLM 265 >gi|11499015 membrane protein [Archaeoglobus fulgidus] >gi|6647985|sp|O28852|YE20_ARCFU HYPOTHETICAL PROTEIN AF1420 >gi|7447605|pir||C69427 membrane protein homolog - Archaeoglobus fulgidus >gi|2649154|gb|AAB89829.1| (AE001006) membrane protein [Archaeoglobus fulgidus] Length = 249 Score = 189 bits (475), Expect = 3e-47 Identities = 101/237 (42%), Positives = 154/237 (64%), Gaps = 5/237 (2%) Query: 15 IFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLREHVIDVPP 74 I +++ LL +V++++ Y++G++ RLG+ PG+ FIIP +E + VVDLR DVP Sbjct: 10 IVVVLFLLSAVRIVKEYERGVIFRLGRLVGARGPGLFFIIPILENMVVVDLRTVTYDVPS 69 Query: 75 QEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLS 134 QEV+ KDNV V V+AVVYY+++DP KAV V D+ A +LAQT LR+IIG+ ELDE LS Sbjct: 70 QEVVTKDNVTVKVNAVVYYRVVDPAKAVTEVFDYQYATAQLAQTTLRSIIGQAELDEVLS 129 Query: 135 GRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAE 194 RD +N KL++ +D+ T+ WG+K+T VEI+ ++ P++++ MA Q AERE+R+ I+ AE Sbjct: 130 ERDKLNVKLQQIIDEETNPWGIKVTAVEIKDVELPEEMRRIMAMQAEAERERRSKIIRAE 189 Query: 195 GKKEAAIREAE-----GQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEK 246 G+ +AA++ E Q + AIL + +I + + +E LK EK Sbjct: 190 GEYQAAMKLREAADVLAQSEGAILLRYLQTLNEISAEQNTTIVMPIPVELLKFFVEK 246 >pir||F70378 erythrocyte band 7 homolog - Aquifex aeolicus >gi|2983432|gb|AAC07014.1| (AE000713) erythrocyte band 7 homolog [Aquifex aeolicus] Length = 253 Score = 183 bits (461), Expect = 2e-45 Identities = 91/198 (45%), Positives = 138/198 (68%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLREHVI 70 I + I +L+ L ++KVI Y++ +V RLG+ PG+ +IP ++R+ V LR + Sbjct: 9 IFIAILVLLFLASAIKVIPEYERAVVFRLGRVIGAKGPGLIIVIPIIDRIVRVSLRTVTL 68 Query: 71 DVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELD 130 DVP Q+VI KDNV V VDAVVY++++DPVKA+ V D+ A ++AQT LR++ GE ELD Sbjct: 69 DVPTQDVITKDNVTVQVDAVVYFRVVDPVKAIVEVEDYFYATSQIAQTTLRSVCGEAELD 128 Query: 131 ETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMI 190 E LS R+ IN KL+E +D+ TD WGVK+ VE+++ID P+++++A+A+Q AERE+RA I Sbjct: 129 ELLSQREKINMKLQEIIDRQTDPWGVKVIAVELKKIDLPEELRKALARQAEAERERRAKI 188 Query: 191 LIAEGKKEAAIREAEGQK 208 + AE + +AA + E + Sbjct: 189 ISAEAEYQAAQKLLEAAR 206 >pir||T39599 conserved hypothetical protein SPBC16G5.07c - fission yeast (Schizosaccharomyces pombe) >gi|3133101|emb|CAA19027.1| (AL023554) conserved hypothetical protein. [Schizosaccharomyces pombe] Length = 354 Score = 183 bits (459), Expect = 3e-45 Identities = 110/292 (37%), Positives = 169/292 (57%), Gaps = 30/292 (10%) Query: 35 LVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 +VER+G+F+R+L PG+ F+ P ++++ + L+E +++P Q I DNV + +D V+Y Sbjct: 63 VVERMGRFSRILTPGVAFLAPIIDKIAYIHSLKERALEIPTQSAITLDNVSLGLDGVLYI 122 Query: 94 QILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDR 153 Q+ DP KA Y V D AI +LAQT +R+ IG + LD L R +N + + ++K + Sbjct: 123 QVYDPYKASYGVEDADYAISQLAQTTMRSEIGRLTLDHVLRERQSLNIHITDAINKAAES 182 Query: 154 WGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAIL 213 WG++ R EI+ I PP+ + AM +Q++AER+KRA IL +EGK++AAI AEG KQA IL Sbjct: 183 WGIRCLRHEIRDIRPPESVVMAMHQQVSAERQKRAEILESEGKRQAAINVAEGDKQAEIL 242 Query: 214 KAEGEKQRQILIAEGQAEAIRKVLEALK-----MAD------------EKYLTLQYIEKL 256 +EG+K + I A +A+AIR+ A +AD Y+ QYI Sbjct: 243 DSEGQKIKTINSALAEAQAIREKASATASGIAVLADSIKKQEHGLEAVSLYIAQQYITNF 302 Query: 257 PDLAKYGN-LIVPYDTESLIGL----LRVLQKV-------KSIPLQQSTEKK 296 LAK N +IVP T + G+ L + ++V KS P + T++K Sbjct: 303 GKLAKASNSMIVPASTSDVSGMVAQALSIFKQVSKTTAPDKSTPKELHTDEK 354 >pir||B71689 hypothetical protein RP328 - Rickettsia prowazekii >gi|3860888|emb|CAA14788.1| (AJ235271) unknown [Rickettsia prowazekii] Length = 311 Score = 182 bits (458), Expect = 3e-45 Identities = 110/310 (35%), Positives = 176/310 (56%), Gaps = 27/310 (8%) Query: 9 ALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVD-LRE 67 AL+I I +++++ VKV+ Q +VE+LGKF+++L PG++ +IP ++RV L+E Sbjct: 4 ALLIFSIITILVIIQMVKVVPQQQAWVVEKLGKFDKVLQPGLNLLIPIIQRVAYKHTLKE 63 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 IDV Q I DNV +++D V+Y +I+DP+ A Y V++ AI +LAQT +R+ IG++ Sbjct: 64 EAIDVTAQTAISNDNVTLSIDGVLYVKIIDPMAASYGVNNPYYAITQLAQTTMRSEIGKL 123 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKR 187 LD T RD +N + +++ WG++ R EI+ I PP+ I +AM Q+ AER+KR Sbjct: 124 PLDRTFEERDTLNVAIVSAINQAAINWGIQCMRYEIKDIQPPQTILKAMELQVAAERQKR 183 Query: 188 AMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKV-------LEAL 240 A IL +EG ++A I AEG+K +L +E Q+ A+G+AEAI V +E + Sbjct: 184 AQILESEGNRQAKINHAEGEKAQIVLNSEASYTDQVNRAKGEAEAIGLVATATANSIEIV 243 Query: 241 KMADEK---------YLTLQYIEKLPDLAKYGNLIV-----PYDTESLIGLLRVLQKVKS 286 A +K + QYI +LAK N ++ + + G L + ++K+ Sbjct: 244 AAAIQKTGGSDAVALKIAEQYISAFGNLAKDTNTVILPTNLSEPSSFVTGALTIFNQLKT 303 Query: 287 IPLQQSTEKK 296 S EKK Sbjct: 304 -----SAEKK 308 >gi|7305503 stomatin-like protein 2 [Homo sapiens] >gi|6456118|gb|AAF09142.1|AF190167_1 (AF190167) membrane associated protein SLP-2 [Homo sapiens] >gi|9652259|gb|AAF91466.1|AF282596_1 (AF282596) stomatin-like protein 2 [Homo sapiens] Length = 356 Score = 179 bits (449), Expect = 4e-44 Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 22/274 (8%) Query: 24 SVKVIRPYQKG-LVERLGKFNRLLDPGIHFIIPFMERVKVVD-LREHVIDVPPQEVICKD 81 +V + P Q+ +VER+G+F+R+L+PG++ +IP ++R++ V L+E VI+VP Q + D Sbjct: 36 TVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLD 95 Query: 82 NVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINA 141 NV + +D V+Y +I+DP KA Y V D A+ +LAQT +R+ +G++ LD+ R+ +NA Sbjct: 96 NVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNA 155 Query: 142 KLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAI 201 + + +++ D WG++ R EI+ I P ++E+M Q+ AER KRA +L +EG +E+AI Sbjct: 156 SIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAI 215 Query: 202 REAEGQKQAAILKAEGEKQRQILIAEGQ-----------AEAIRKVLEALKM-----ADE 245 AEG+KQA IL +E EK QI A G+ AEAIR + AL A Sbjct: 216 NVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAAS 275 Query: 246 KYLTLQYIEKLPDLAKYGNLIV----PYDTESLI 275 + QY+ LAK N I+ P D S++ Sbjct: 276 LTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMV 309 >gi|11429564 stomatin-like protein 2 [Homo sapiens] Length = 377 Score = 179 bits (449), Expect = 4e-44 Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 22/274 (8%) Query: 24 SVKVIRPYQKG-LVERLGKFNRLLDPGIHFIIPFMERVKVVD-LREHVIDVPPQEVICKD 81 +V + P Q+ +VER+G+F+R+L+PG++ +IP ++R++ V L+E VI+VP Q + D Sbjct: 57 TVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLD 116 Query: 82 NVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINA 141 NV + +D V+Y +I+DP KA Y V D A+ +LAQT +R+ +G++ LD+ R+ +NA Sbjct: 117 NVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNA 176 Query: 142 KLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAI 201 + + +++ D WG++ R EI+ I P ++E+M Q+ AER KRA +L +EG +E+AI Sbjct: 177 SIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAI 236 Query: 202 REAEGQKQAAILKAEGEKQRQILIAEGQ-----------AEAIRKVLEALKM-----ADE 245 AEG+KQA IL +E EK QI A G+ AEAIR + AL A Sbjct: 237 NVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAAS 296 Query: 246 KYLTLQYIEKLPDLAKYGNLIV----PYDTESLI 275 + QY+ LAK N I+ P D S++ Sbjct: 297 LTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMV 330 >pir||A83590 probable stomatin-like protein PA0452 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9946311|gb|AAG03841.1|AE004482_8 (AE004482) probable stomatin-like protein [Pseudomonas aeruginosa] Length = 264 Score = 178 bits (446), Expect = 9e-44 Identities = 85/200 (42%), Positives = 146/200 (72%), Gaps = 2/200 (1%) Query: 1 MMISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERV 60 MM + G+A+++ +FL ++L +++++R Y++G+V +LG+F ++ PG+ +IP ++++ Sbjct: 1 MMGISYGLAMLL--VFLALLLFSALRILREYERGVVFQLGRFWKVKGPGLVLVIPAIQQM 58 Query: 61 KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNL 120 +DLR V+DVPPQ+VI +DNV V V+AVVY+++LDP KA+ V ++L A +LAQT L Sbjct: 59 VRIDLRTIVLDVPPQDVISRDNVSVKVNAVVYFRVLDPQKAIIQVENYLAATSQLAQTTL 118 Query: 121 RAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQM 180 RA++G+ ELDE L+ R+ +N +++ LD TD WG+K+ VEI+ +D + + A+A+Q Sbjct: 119 RAVLGKHELDEMLAERERLNLDIQQVLDAQTDAWGIKVANVEIKHVDLNESMVRAIARQA 178 Query: 181 TAEREKRAMILIAEGKKEAA 200 AERE+RA ++ AEG+ +A+ Sbjct: 179 EAERERRAKVIHAEGELQAS 198 >gb|AAF29073.1|AF161458_1 (AF161458) HSPC108 [Homo sapiens] Length = 342 Score = 177 bits (444), Expect = 1e-43 Identities = 104/274 (37%), Positives = 163/274 (58%), Gaps = 22/274 (8%) Query: 24 SVKVIRPYQKG-LVERLGKFNRLLDPGIHFIIPFMERVKVVD-LREHVIDVPPQEVICKD 81 +V + P Q+ +VER+G+F+R+L+PG++ +IP ++R++ V L+E VI+VP Q + D Sbjct: 22 TVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLD 81 Query: 82 NVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINA 141 NV + +D V+Y +I+DP KA Y V D A+ +LAQT +R+ +G++ LD+ R+ +NA Sbjct: 82 NVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNA 141 Query: 142 KLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAI 201 + + +++ D WG++ R EI+ I P ++E+M Q+ AER KR +L +EG +E+AI Sbjct: 142 SIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRPTVLESEGTRESAI 201 Query: 202 REAEGQKQAAILKAEGEKQRQILIAEGQ-----------AEAIRKVLEALKM-----ADE 245 AEG+KQA IL +E EK QI A G+ AEAIR + AL A Sbjct: 202 NVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAAS 261 Query: 246 KYLTLQYIEKLPDLAKYGNLIV----PYDTESLI 275 + QY+ LAK N I+ P D S++ Sbjct: 262 LTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMV 295 >gb|AAF47110.1| (AE003462) CG2970 gene product [Drosophila melanogaster] Length = 323 Score = 175 bits (440), Expect = 4e-43 Identities = 99/250 (39%), Positives = 150/250 (59%), Gaps = 17/250 (6%) Query: 35 LVERLGKFNRLLDPGIHFIIPFMERVKVVD-LREHVIDVPPQEVICKDNVVVTVDAVVYY 93 +VER+G+F+R+LDPG++ ++P +++K V L+E IDVP Q I DNV +++D V+Y Sbjct: 10 VVERMGRFHRILDPGLNILVPVADKIKYVQSLKEIAIDVPKQSAITSDNVTLSIDGVLYL 69 Query: 94 QILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDR 153 +I+DP KA Y V D AI +LAQT +R+ +G+M +D+ R+ +N + + ++K ++ Sbjct: 70 RIIDPYKASYGVEDPEFAITQLAQTTMRSELGKMSMDKVFRERESLNVSIVDSINKASEA 129 Query: 154 WGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAIL 213 WG+ R EI+ I P + EAM Q+ AER KRA IL +EG +EA I AEG++++ IL Sbjct: 130 WGIACLRYEIRDIRLPTRVHEAMQMQVEAERRKRAAILESEGVREAEINIAEGKRKSRIL 189 Query: 214 KAEGEKQRQILIAEGQAEAIRKVLEA--------------LKMADEKYLTL--QYIEKLP 257 +E E+Q I A G+A AI V +A L + LTL QYI Sbjct: 190 ASEAERQEHINKASGEAAAIIAVADARARSLLAIAKSLSHLDGQNAASLTLAEQYIGAFK 249 Query: 258 DLAKYGNLIV 267 LAK N ++ Sbjct: 250 KLAKTNNTMI 259 >pir||T21562 hypothetical protein F30A10.5 - Caenorhabditis elegans >gi|3876548|emb|CAB03018.1| (Z81072) predicted using Genefinder~Similarity to Human erythrocyte band 7 integral membrane protein (SW:BAN7_HUMAN), contains similarity to Pfam domain: PF01145 (SPFH domain / Band 7 family), Score=170.0, E-value=1.3e-47, N=1~cDNA EST yk543b6.3 comes > Length = 334 Score = 173 bits (434), Expect = 2e-42 Identities = 97/253 (38%), Positives = 156/253 (61%), Gaps = 20/253 (7%) Query: 35 LVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 +VER+GKF ++L+PG++F++P ++++K V +LRE I++P Q I DNV + +D V+Y Sbjct: 55 VVERMGKFYKILEPGLNFLLPIIDKIKFVQNLREIAIEIPEQGAITIDNVQLRLDGVLYL 114 Query: 94 QILDPVKAV---YNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKI 150 ++ DP KA Y V D A+ +LAQT +R+ +G++ LD R+++N + ++K Sbjct: 115 RVFDPYKACDASYGVDDPEFAVTQLAQTTMRSEVGKINLDTVFKERELLNENIVFAINKA 174 Query: 151 TDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQA 210 + WG++ R EI+ + P IQEAM Q+ AER+KRA IL +EG +EAAI AEG K++ Sbjct: 175 SAPWGIQCMRYEIRDMQMPSKIQEAMQMQVEAERKKRAAILESEGIREAAINRAEGDKKS 234 Query: 211 AILKAEGEKQRQILIAEGQAEAI-------RKVLEALKMADEK---------YLTLQYIE 254 AIL +E + +I +A+G+AEA+ K +E + +A EK + QY+ Sbjct: 235 AILASEAVQAERINVAKGEAEAVILKAESRAKAIERIALALEKDGGANAAGLTVAEQYVG 294 Query: 255 KLPDLAKYGNLIV 267 +LAK N +V Sbjct: 295 AFGNLAKESNTVV 307 >gb|AAF68388.1|AF236372_1 (AF236372) stomatin-like protein [Zea mays] Length = 394 Score = 171 bits (429), Expect = 9e-42 Identities = 104/268 (38%), Positives = 158/268 (58%), Gaps = 20/268 (7%) Query: 25 VKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHVIDVPPQEVICKDNV 83 V ++ + +VER GK+ + L G H +IP ++R+ V L+E I +P Q I KDNV Sbjct: 58 VSIVPEKKAYVVERFGKYLKTLGSGFHLLIPAVDRIAYVHSLKEETIPIPHQNAITKDNV 117 Query: 84 VVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKL 143 + +D+V+Y +I+DP A Y V + + A+++LAQT +R+ +G++ LD+T RD +N K+ Sbjct: 118 TIQIDSVIYVKIMDPYLASYGVENPIYAVLQLAQTTMRSELGKITLDKTFEERDALNEKI 177 Query: 144 REELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIRE 203 +++ WG+K R EI+ I+PP I++AM Q AER+KRA IL +EG K+A I E Sbjct: 178 VSAINEAATDWGLKCIRYEIRDINPPAGIRQAMEMQAEAERKKRAQILESEGMKQAQILE 237 Query: 204 AEGQKQAAILKAEGEKQRQILIAEGQAEAI-----------RKVLEAL------KMADEK 246 +EG+K A IL++EG A+G AEAI R V +A+ K A K Sbjct: 238 SEGKKTAQILESEGAMLDLANRAKGAAEAILAKSEATARGMRLVSDAMTTEGSAKAASLK 297 Query: 247 YLTLQYIEKLPDLA-KYGNLIVPYDTES 273 L QYIE +LA K +++P D+ S Sbjct: 298 -LAEQYIEAFSNLAQKTNTMLLPGDSAS 324 >pir||T02246 hypothetical protein P1.11659_4 - human >gi|2984585|gb|AAC07983.1| (AC004472) P1.11659_4 [Homo sapiens] Length = 357 Score = 169 bits (424), Expect = 3e-41 Identities = 105/288 (36%), Positives = 164/288 (56%), Gaps = 36/288 (12%) Query: 24 SVKVIRPYQKG-LVERLGKFNRLLDPGIHFIIPFMERVKVVD-LREHVIDVPPQEVICKD 81 +V + P Q+ +VER+G+F+R+L+PG++ +IP ++R++ V L+E VI+VP Q + D Sbjct: 23 TVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLD 82 Query: 82 NVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINA 141 NV + +D V+Y +I+DP KA Y V D A+ +LAQT +R+ +G++ LD+ R+ +NA Sbjct: 83 NVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNA 142 Query: 142 KLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQ--------------MTAEREKR 187 + + +++ D WG++ R EI+ I P ++E+M Q + AER KR Sbjct: 143 SIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVGAKEGWEKGLRAPVEAERRKR 202 Query: 188 AMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQ-----------AEAIRKV 236 A +L +EG +E+AI AEG+KQA IL +E EK QI A G+ AEAIR + Sbjct: 203 ATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRIL 262 Query: 237 LEALKM-----ADEKYLTLQYIEKLPDLAKYGNLIV----PYDTESLI 275 AL A + QY+ LAK N I+ P D S++ Sbjct: 263 AAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMV 310 >pir||T18493 hypothetical protein C0800w - malaria parasite (Plasmodium falciparum) >gi|3758847|emb|CAB11132.1| (Z98551) band 7-related protein [Plasmodium falciparum] Length = 374 Score = 168 bits (420), Expect = 1e-40 Identities = 95/251 (37%), Positives = 149/251 (58%), Gaps = 7/251 (2%) Query: 35 LVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 +VERLGK+N+ L GIHF+IPF++++ V L+E I +P Q I KDNV + +D V+Y Sbjct: 89 IVERLGKYNKTLLAGIHFLIPFIDKIAYVFSLKEETITIPNQTAITKDNVTLNIDGVLYI 148 Query: 94 QILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDR 153 + +P + Y + D + A+ +LAQ +R+ +G++ LD T RD +N KL + +++ Sbjct: 149 KCDNPYNSSYAIEDAVFAVTQLAQVTMRSELGKLTLDATFLERDNLNEKLVKAINESAKN 208 Query: 154 WGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAIL 213 WG+K R EI+ I P +I+ AM KQ AER KRA IL +EG++E+ I A G+K+ +IL Sbjct: 209 WGIKCMRYEIRDIILPVNIKNAMEKQAEAERRKRAEILQSEGERESEINIAIGKKRKSIL 268 Query: 214 KAEGEKQRQILIAEGQAEAIRKVLEALKMADEK-----YLTLQYIEKLPDLAKYGN-LIV 267 AEG+ A+ AEAI + +K D + QYI+ ++ K N +I+ Sbjct: 269 IAEGQSFAIKAKADATAEAIEIISNKIKKLDSNNAISLLVAEQYIDVFSNICKNNNTVII 328 Query: 268 PYDTESLIGLL 278 P D ++ L+ Sbjct: 329 PADLNNISSLI 339 >pir||T05863 hypothetical protein T29A15.70 - Arabidopsis thaliana >gi|4469009|emb|CAB38270.1| (AL035602) putative protein [Arabidopsis thaliana] >gi|7269612|emb|CAB81408.1| (AL161571) putative protein [Arabidopsis thaliana] Length = 515 Score = 168 bits (420), Expect = 1e-40 Identities = 85/210 (40%), Positives = 135/210 (63%), Gaps = 1/210 (0%) Query: 25 VKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHVIDVPPQEVICKDNV 83 ++++ + ++ER GK+ L GIHF+IPF++R+ V L+E I +P Q I KDNV Sbjct: 63 IRIVPERKAFVIERFGKYATTLPSGIHFLIPFVDRIAYVHSLKEEAIPIPNQTAITKDNV 122 Query: 84 VVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKL 143 + +D V+Y +I+DP A Y V + A+V+LAQT +R+ +G++ LD+T RD +N K+ Sbjct: 123 SIHIDGVLYVKIVDPKLASYGVESPIYAVVQLAQTTMRSELGKITLDKTFEERDTLNEKI 182 Query: 144 REELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIRE 203 E ++ WG++ R EI+ I PP ++ AM Q AER+KRA IL +EG++++ I Sbjct: 183 VEAINVAAKDWGLQCLRYEIRDIMPPHGVRAAMEMQAEAERKKRAQILESEGERQSHINI 242 Query: 204 AEGQKQAAILKAEGEKQRQILIAEGQAEAI 233 A+G+K + IL +E K Q+ A+G+AEAI Sbjct: 243 ADGKKSSVILASEAAKMDQVNRAQGEAEAI 272 >dbj|BAA97132.1| (AB018115) contains similarity to stomatin like protein~gene_id:MJP23.8 [Arabidopsis thaliana] Length = 401 Score = 167 bits (419), Expect = 1e-40 Identities = 96/267 (35%), Positives = 161/267 (59%), Gaps = 18/267 (6%) Query: 25 VKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV-DLREHVIDVPPQEVICKDNV 83 ++++ + ++ER GKF+ L GIHF++PF++R+ V L+E I + Q I KDNV Sbjct: 106 IRIVPERKACVIERFGKFHTTLPAGIHFLVPFVDRIAYVHSLKEEAIPIGNQTAITKDNV 165 Query: 84 VVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKL 143 + +D V+Y +I+DP A Y V + + A+++LAQT +R+ +G++ LD+T RD +N K+ Sbjct: 166 SIHIDGVLYVKIVDPKLASYGVENPIYAVMQLAQTTMRSELGKITLDKTFEERDTLNEKI 225 Query: 144 REELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIRE 203 E ++ WG++ R EI+ I PP ++ AM Q AER+KRA IL +EG+++A I Sbjct: 226 VEAINVAAKDWGLQCLRYEIRDIMPPNGVRVAMEMQAEAERKKRAQILESEGERQAHINR 285 Query: 204 AEGQKQAAILKAEGEKQRQILIAEGQAEAI-----------RKVLEALKMA-DEKYLTL- 250 A+G+K + IL++E Q+ A+G+AEAI V ++LK A E+ +L Sbjct: 286 ADGKKSSVILESEAAMMDQVNRAQGEAEAILARAQATAKGLAMVSQSLKEAGGEEAASLR 345 Query: 251 ---QYIEKLPDLAKYG-NLIVPYDTES 273 QYI+ +AK G +++P + ++ Sbjct: 346 VAEQYIQAFGKIAKEGTTMLLPSNVDN 372 >pir||G69104 stomatin-like protein - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2622911|gb|AAB86246.1| (AE000933) stomatin-like protein [Methanobacterium thermoautotrophicum] Length = 297 Score = 161 bits (403), Expect = 1e-38 Identities = 87/247 (35%), Positives = 149/247 (60%), Gaps = 13/247 (5%) Query: 12 ILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLREHVID 71 +L +++++ LS+K+++ Y++G+V RLGK + +PG+ IIP ++R+ V LR + Sbjct: 51 LLAAVIIVIISLSLKIVKQYERGVVFRLGKVIGVREPGLRIIIPIIDRMVRVSLRIVTMP 110 Query: 72 VPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDE 131 +P Q++I +DNV + V AV Y+++ DP++AV + D+ A+ +++QT +R +IG+ LDE Sbjct: 111 IPSQKIITQDNVSIDVAAVAYFKVADPLRAVVAIEDYYGAVNQISQTTVRNVIGQFVLDE 170 Query: 132 TLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMIL 191 LS IN K++E +D+ ++ WG+ +T VEI+ I P+ +Q AMA+Q AER+KRA I+ Sbjct: 171 VLSETARINEKIKEIIDEHSEPWGINVTTVEIKDIKLPEGMQRAMARQAEAERDKRAKII 230 Query: 192 IAEGKKEAAIREAEG----QKQAAILKAEG---------EKQRQILIAEGQAEAIRKVLE 238 AEG+ +A + E +K L+ EK I+ +IR V E Sbjct: 231 TAEGEYFSAAKLGEAADVIEKHPVALQLRNLQVLAEIATEKNSTIVFPAQFMSSIRDVKE 290 Query: 239 ALKMADE 245 ++ DE Sbjct: 291 FIEREDE 297 >gb|AAC64873.1| (AF034831) stomatin like protein [Rhizobium etli] Length = 222 Score = 159 bits (399), Expect = 3e-38 Identities = 89/228 (39%), Positives = 144/228 (63%), Gaps = 18/228 (7%) Query: 39 LGKFNRLLDPGIHFIIPFMERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDP 98 LG+F + PG+ +IP+++++ VDLR V+DVP Q+VI DNV V V AV+Y++++DP Sbjct: 8 LGRFTGVKGPGLILLIPYVQQMIRVDLRTRVLDVPSQDVISHDNVSVRVSAVIYFRVIDP 67 Query: 99 VKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKI 158 K+ V DF+MA +LAQT LR+++G+ +LDE L+ RD +N+ ++E LD TD WG+K+ Sbjct: 68 EKSTIQVEDFMMATSQLAQTTLRSVLGKHDLDEMLAERDRLNSDIQEILDAQTDAWGIKV 127 Query: 159 TRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGE 218 VEI+ +D + + A+A+Q AERE+RA ++ AEG+++AA A +L+A Sbjct: 128 ATVEIKHVDINESMIRAIARQAEAERERRAKVINAEGEQQAA---------AKLLEA--- 175 Query: 219 KQRQILIAEGQAEAIRKVLEALKMADEKYLTLQYIEKLPDLAKYGNLI 266 +IL + +A +R + +A EK T+ + P + GNL+ Sbjct: 176 --AEILAKQPEAMQLRYLSTLNVIASEKTSTILF----PFPMELGNLM 217 >emb|CAC12423.1| (AL445067) membrane protein 7, erythrocyte (human) related protein [Thermoplasma acidophilum] Length = 274 Score = 155 bits (387), Expect = 7e-37 Identities = 79/202 (39%), Positives = 124/202 (61%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 + LII+ I LI+LL + V++ +++ +V LG++ + PGI FI P + R V R Sbjct: 6 ILLIIIIIIALIILLSGIHVLKEWERAIVLTLGRYGGIRGPGIIFITPIVSRGIYVSTRI 65 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 + + KDNV V VDA++YYQ++DP KAV N+ ++ + AQT LR +IG+ Sbjct: 66 QPVQFKTEATFTKDNVPVNVDAIMYYQVIDPQKAVLNIENYSVGTNYAAQTTLREVIGKS 125 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKR 187 DE LS R+ I RE +D+ T+ WGVK+ VEI+ + P +QEAM++Q +AERE+R Sbjct: 126 MFDELLSEREKIGETAREIIDQKTEAWGVKVASVEIRDVLVPSQLQEAMSRQASAERERR 185 Query: 188 AMILIAEGKKEAAIREAEGQKQ 209 + + +A+ + EAA + E +Q Sbjct: 186 SRVTLAQAEVEAAQKMVEASRQ 207 >gb|AAF48927.1| (AE003511) CG7633 gene product [Drosophila melanogaster] Length = 339 Score = 153 bits (384), Expect = 2e-36 Identities = 85/206 (41%), Positives = 127/206 (61%), Gaps = 4/206 (1%) Query: 3 ISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERV 60 I A V+++I+ + I + + KV+ Y++ ++ R+G+ PG+ F++P ++ Sbjct: 6 ILATVVSVLIMVLTFPISVFICFKVVSEYERAVIFRMGRLRSGGARGPGVFFVLPCVDDY 65 Query: 61 KVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNL 120 VDLR DVPPQEV+ KD+V VTVDAVVYY+I DP+KAV V ++ + LA T L Sbjct: 66 YPVDLRTVSFDVPPQEVLSKDSVTVTVDAVVYYRISDPLKAVIQVYNYSHSTSLLAATTL 125 Query: 121 RAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQM 180 R ++G L E L+ R+ I+ ++ LD+ TD WGVK+ RVEI+ + P +Q AMA + Sbjct: 126 RNVLGTRNLSELLTERETISHTMQMSLDEATDPWGVKVERVEIKDVSLPTALQRAMAAEA 185 Query: 181 TAEREKRAMILIAEG--KKEAAIREA 204 A RE RA ++ AEG K A+REA Sbjct: 186 EAAREARAKVIAAEGEMKSSRALREA 211 >gb|AAF48928.1| (AE003511) CG7635 gene product [Drosophila melanogaster] Length = 350 Score = 150 bits (375), Expect = 2e-35 Identities = 97/269 (36%), Positives = 151/269 (56%), Gaps = 22/269 (8%) Query: 8 VALIILGIFLL---IMLLLSVKVIRPYQKGLVERLGKFNR-LLDPGIHFIIPFMERVKVV 63 V L + IF++ I + + KV+ Y++ ++ RLG+ + PG+ FI+P ++ + V Sbjct: 69 VTLFSVLIFIITSPIAIFICFKVVAEYERAIIFRLGRLSGGARGPGMFFILPCIDEYRKV 128 Query: 64 DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAI 123 DLR +VP QE++ KD+V VTVDAVVYY+I DP+ AV V D+ M+ LA T LR I Sbjct: 129 DLRTVTFNVPQQEMLTKDSVTVTVDAVVYYRISDPLYAVIQVEDYSMSTRLLAATTLRNI 188 Query: 124 IGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAE 183 +G L E L+ R+ + ++ LD+ T+ WGV + RVEI+ + P +Q AMA + A Sbjct: 189 VGTRNLSELLTERETLAHNMQATLDEATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAA 248 Query: 184 REKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMA 243 R+ RA ++ AEG+K K A LK + ++ A A +R + ++ Sbjct: 249 RDARAKVIAAEGEK----------KSATALKEASD----VISASPSALQLRYLQTLSSIS 294 Query: 244 DEKYLTLQY---IEKL-PDLAKYGNLIVP 268 EK T+ + +E L P LAKY +L+ P Sbjct: 295 AEKNSTIIFPLPMELLTPYLAKYAHLMGP 323 >sp|Q27433|MEC2_CAEEL MECHANOSENSORY PROTEIN 2 >gi|2133486|pir||S60260 stomatin-like protein - Caenorhabditis elegans >gi|973210|gb|AAA87551.1| (U26735) MEC-2 [Caenorhabditis elegans] >gi|973212|gb|AAA87552.1| (U26736) MEC-2 [Caenorhabditis elegans] >gi|1086680|gb|AAA82333.1| (U41021) C. elegans mec-2 (GB:U26735) [Caenorhabditis elegans] >gi|1585780|prf||2201490A stomatin-like protein [Caenorhabditis elegans] Length = 481 Score = 148 bits (370), Expect = 7e-35 Identities = 86/224 (38%), Positives = 133/224 (58%), Gaps = 11/224 (4%) Query: 7 GVALIILGIFLLIMLL-----LSVKVIRPYQKGLVERLGKF--NRLLDPGIHFIIPFMER 59 G L IL L+ L + +KV++ Y++ ++ RLG+ PGI FI+P ++ Sbjct: 118 GWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKGPGIFFIVPCIDT 177 Query: 60 VKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTN 119 + VDLR +VPPQE++ KD+V V VDAVVY++I + +V NV D + LAQT Sbjct: 178 YRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVEDAARSTKLLAQTT 237 Query: 120 LRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQ 179 LR I+G L E LS R+ I+ +++ LD+ T+ WGVK+ RVE++ + P +Q AMA + Sbjct: 238 LRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVRLPVQLQRAMAAE 297 Query: 180 MTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQI 223 A RE RA +++AEG+++A + K+AA + AE Q+ Sbjct: 298 AEAAREARAKVIVAEGEQKA----SRALKEAAEVIAESPSALQL 337 >emb|CAA73876.1| (Y13473) stomatin [Danio rerio] Length = 284 Score = 147 bits (367), Expect = 2e-34 Identities = 83/224 (37%), Positives = 130/224 (57%), Gaps = 11/224 (4%) Query: 7 GVALIILGIFLLIMLL-----LSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMER 59 G L+I I L ++ L + +K+++ Y++ ++ RLG+ R PG+ FI+P + Sbjct: 33 GWILVIFSILLTLLTLPLSIWMCIKIVKEYERAIIFRLGRILRGGAKGPGLFFILPCTDS 92 Query: 60 VKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTN 119 VD+R D+PPQEV+ KD+V V+VD VVYY++ + AV N+++ A LAQT Sbjct: 93 FINVDMRTITFDIPPQEVLTKDSVTVSVDGVVYYRVQNATLAVANITNADAATRLLAQTT 152 Query: 120 LRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQ 179 LR ++G L E LS R+ I ++ LD TD WG+K+ RVEI+ + P +Q AMA + Sbjct: 153 LRNVLGTKNLAEILSDREEIAHSMQSTLDDATDDWGIKVERVEIKDVKLPLQLQRAMAAE 212 Query: 180 MTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQI 223 A RE RA ++ AEG+ A + K+A+++ AE Q+ Sbjct: 213 AEASREARAKVIAAEGEMNA----SRALKEASLVIAESPSALQL 252 >emb|CAB76415.1| (Z66565) contains similarity to Pfam domain: PF01145 (SPFH domain / Band 7 family), Score=369.9, E-value=8.6e-108, N=1~cDNA EST yk67b6.5 comes from this gene~cDNA EST yk82a9.5 comes from this gene~cDNA EST yk392b12.3 comes from this gene~cDNA EST yk440> >gi|7321105|emb|CAB82215.1| (AL032659) contains similarity to Pfam domain: PF01145 (SPFH domain / Band 7 family), Score=369.9, E-value=8.6e-108, N=1~cDNA EST yk67b6.5 comes from this gene~cDNA EST yk82a9.5 comes from this gene~cDNA EST yk392b12.3 comes from this gene~cDNA EST yk4> Length = 281 Score = 146 bits (364), Expect = 4e-34 Identities = 84/201 (41%), Positives = 122/201 (59%), Gaps = 6/201 (2%) Query: 6 GGVALIILGIFLLIMLLLS----VKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMER 59 G + II + +L L LS +KV++ Y++ ++ RLG+ PGI FIIP +E Sbjct: 27 GWIITIISYLVVLFTLPLSAFFCLKVVQEYERAVIFRLGRLKHGGARGPGIFFIIPCIES 86 Query: 60 VKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTN 119 K +DLR DVPPQE++ KD+V V+VDAV+Y++I + +V NV D + LAQT Sbjct: 87 FKKIDLRVVSFDVPPQEILSKDSVTVSVDAVIYFRISNATVSVINVEDAARSTKLLAQTT 146 Query: 120 LRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQ 179 LR +G L E LS RD I+ +++ LD+ TD WGVK+ RVEI+ + P +Q AMA + Sbjct: 147 LRNFLGTRTLAEMLSSRDAISMQMQAALDEATDPWGVKVERVEIKDVRLPIQLQRAMAAE 206 Query: 180 MTAEREKRAMILIAEGKKEAA 200 A R A I+ AEG++ A+ Sbjct: 207 AEAARAAGAKIIAAEGEQLAS 227 >pir||T34691 hypothetical protein SC1B5.13c SC1B5.13c - Streptomyces coelicolor >gi|3130017|emb|CAA18987.1| (AL023517) hypothetical protein SC1B5.13c [Streptomyces coelicolor A3(2)] Length = 262 Score = 145 bits (361), Expect = 8e-34 Identities = 88/273 (32%), Positives = 153/273 (55%), Gaps = 34/273 (12%) Query: 24 SVKVIRPYQKGLVERLGKF-NRLLDPGIHFIIPFMERVKVVDLREHVIDVPPQEVICKDN 82 + +V++ Y++G+V RLG+ + PG I+PF++R+ V+++ + VP QE I +DN Sbjct: 23 AARVVKQYERGVVFRLGRLAGQARGPGFTMIVPFVDRLHKVNMQIITLPVPAQEGITRDN 82 Query: 83 VVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAK 142 V V VDAVVY++++D A+ V D+ A+ ++AQT+LR+IIG+ +LD+ LS R+ +N Sbjct: 83 VTVRVDAVVYFKVVDAANALVRVEDYRFAVSQMAQTSLRSIIGKSDLDDLLSDREKLNQG 142 Query: 143 LREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIR 202 L +D WGV+I RVEI+ + P ++ +MA+Q A+RE+RA ++ A+ + +A+ Sbjct: 143 LELMIDSPAVGWGVQIDRVEIKDVSLPDTMKRSMARQAEADRERRARVINADAELQASKV 202 Query: 203 EAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEKYLTLQYIEKLPDLAKY 262 AE ++ + A A +R + + +A EK T Sbjct: 203 LAEAAREMSETPA--------------ALQLRLLQTVVAVAAEKNST------------- 235 Query: 263 GNLIVPYDTESLIGLLRVLQKVKSIPLQQSTEK 295 L++P+ E LLR L+K + P++ E+ Sbjct: 236 --LVLPFPVE----LLRFLEKAQEHPVEHRVER 262 >sp|Q19200|STO1_CAEEL STO-1 PROTEIN >gi|7447613|pir||T15971 hypothetical protein F08C6.4 - Caenorhabditis elegans >gi|868187|gb|AAA68723.1| (U29378) similar to erythrocyte band 7 integral membrane protein (SP:BAN7_HUMAN, P27105) [Caenorhabditis elegans] Length = 281 Score = 141 bits (353), Expect = 7e-33 Identities = 84/213 (39%), Positives = 127/213 (59%), Gaps = 6/213 (2%) Query: 16 FLLIMLLLSVKV---IRPYQKGLVERLGKF-NRLLDPGIHFIIPFMERVKVVDLREHVID 71 ++LI L V V I+ YQ+ +V RLG+ + PGI FIIP ++ +DLR + Sbjct: 3 YVLIFLTFPVSVFMCIKEYQRAVVFRLGRLVPDVKGPGIFFIIPCIDTFLNIDLRVASYN 62 Query: 72 VPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDE 131 VP QE++ +D+V V+VDAVVY+++ DP+ +V V + + LAQT LR I+G L E Sbjct: 63 VPSQEILSRDSVTVSVDAVVYFKVFDPITSVVGVGNATDSTKLLAQTTLRTILGTHTLSE 122 Query: 132 TLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMIL 191 LS R+ I+A ++ LD+ T+ WG+K+ RVE++ + P +Q AMA + A R+ A I+ Sbjct: 123 ILSDREKISADMKISLDEATEPWGIKVERVELRDVRLPSQMQRAMAAEAEATRDAGAKII 182 Query: 192 IAEGKKEAAIREAEGQKQAAILKAEGEKQRQIL 224 AEG+ A+ AE I K+EG Q + L Sbjct: 183 AAEGELRASAALAEA--ATIISKSEGAMQLRYL 213 >sp|Q22165|STO4_CAEEL STO-4 PROTEIN Length = 213 Score = 141 bits (352), Expect = 9e-33 Identities = 76/177 (42%), Positives = 111/177 (61%), Gaps = 2/177 (1%) Query: 26 KVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERVKVVDLREHVIDVPPQEVICKDNV 83 +V++ Y++ ++ RLG+ PGI FIIP +E K +DLR DVPPQE++ KD+V Sbjct: 8 QVVQEYERAVIFRLGRLKHGGARGPGIFFIIPCIESFKKIDLRVVSFDVPPQEILSKDSV 67 Query: 84 VVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKL 143 V+VDAV+Y++I + +V NV D + LAQT LR +G L E LS RD I+ ++ Sbjct: 68 TVSVDAVIYFRISNATVSVINVEDAARSTKLLAQTTLRNFLGTRTLAEMLSSRDAISMQM 127 Query: 144 REELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAA 200 + LD+ TD WGVK+ RVEI+ + P +Q AMA + A R A I+ AEG++ A+ Sbjct: 128 QAALDEATDPWGVKVERVEIKDVRLPIQLQRAMAAEAEAARAAGAKIIAAEGEQLAS 184 >gb|AAF14646.1|AF163772_6 (AF163772) 7138.6 [Leishmania major] Length = 357 Score = 141 bits (352), Expect = 9e-33 Identities = 86/251 (34%), Positives = 137/251 (54%), Gaps = 18/251 (7%) Query: 35 LVERLGKFNRLLDPGIHFIIPFMERVKV-VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 +VERLG+++R LD G ++PF+++++ +++E I++P Q I DNV+V +D V++ Sbjct: 72 VVERLGRYHRTLDSGWWVVVPFIDKIRYNYNVKEQGIEIPNQSAITSDNVMVEIDGVLFL 131 Query: 94 QILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDR 153 +I+D KA YN+ + + ++ LAQT +R+ IG M LD R +N E L + + Sbjct: 132 KIVDSCKASYNIENPVFNLINLAQTTMRSEIGRMSLDSLFRERASLNQSTVEVLRREANE 191 Query: 154 WGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAIL 213 WG++ R EI+ I + ++ +M Q AER+KR +IL +EG+ A I A G K A Sbjct: 192 WGIECKRYEIRDIVVSELVRRSMDLQAEAERKKRKLILESEGESTATINRANGMKIAQQC 251 Query: 214 KAEGEKQRQILIAEGQAEAIR--------------KVLEALKMADEKY---LTLQYIEKL 256 A+ EK +EG A AIR +E K ++E + YIEK Sbjct: 252 VADAEKYTAERQSEGAAAAIRVKAAAVSDNISIVSDAIEKAKHSNEAISLRVAESYIEKF 311 Query: 257 PDLAKYGNLIV 267 +LAK N +V Sbjct: 312 GELAKESNTVV 322 >gb|AAF54744.1| (AE003694) CG17424 gene product [Drosophila melanogaster] Length = 474 Score = 141 bits (351), Expect = 1e-32 Identities = 69/197 (35%), Positives = 124/197 (62%), Gaps = 4/197 (2%) Query: 8 VALIILGIFLLIMLLLSV----KVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV 63 VA+ + I +LI+L S+ + + + ++ RLG+ L PG+ F++P ++ V Sbjct: 31 VAVFVSWILVLILLPFSLCCCLTIAYEFHRLVIFRLGRIRSCLGPGLVFLLPCIDSFNTV 90 Query: 64 DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAI 123 D+R V++V PQE++ KD+V +TV+AVV+Y I DP+ ++ V D A +++Q LR I Sbjct: 91 DIRTDVVNVDPQEMLTKDSVSITVNAVVFYCIYDPINSIIKVDDARDATERISQVTLRNI 150 Query: 124 IGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAE 183 +G L E L+ R ++ ++++ + KIT+RWGV++ RV++ I P ++ ++A + A Sbjct: 151 VGSKGLHELLASRQQLSLEIQQAVAKITERWGVRVERVDLMEISLPSSLERSLASEAEAT 210 Query: 184 REKRAMILIAEGKKEAA 200 RE RA I++AEG+ +A+ Sbjct: 211 REARAKIILAEGEAKAS 227 >sp|Q21190|UNC1_CAEEL UNC-1 PROTEIN >gi|7494583|pir||T34324 erythrocyte band 7 intergral membrane protein homolog unc-1 - Caenorhabditis elegans >gi|1280125|gb|AAC69044.1| (U55375) Erythrocyte band 7 intergral membrane protein [Caenorhabditis elegans] Length = 282 Score = 140 bits (350), Expect = 2e-32 Identities = 84/213 (39%), Positives = 129/213 (60%), Gaps = 9/213 (4%) Query: 7 GVALIILGIFLLIM-----LLLSVKVIRPYQKGLVERLGK--FNRLLDPGIHFIIPFMER 59 G AL L L+I+ + + +KVI+ Y++ ++ R+G+ F PG+ FIIP ++ Sbjct: 29 GYALQALSWILIIVTFPFSMCVCLKVIKEYERVVIFRIGRLVFGGARGPGMIFIIPCIDT 88 Query: 60 VKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTN 119 + +DLR VPPQE++ KD+V V+VDAVVY++ DP+ +V NV D + + LAQT Sbjct: 89 YRKIDLRVVSYAVPPQEILSKDSVTVSVDAVVYFRTSDPIASVNNVDDAIYSTKLLAQTT 148 Query: 120 LRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQ 179 LR +G L E L+ R+ I LD+ T+ WGVK+ RVE++ I P+ + AMA + Sbjct: 149 LRNALGMKTLTEMLTEREAIAQLCETILDEGTEHWGVKVERVEVKDIRLPQQLTRAMAAE 208 Query: 180 MTAEREKRAMILIAEGKKEA--AIREAEGQKQA 210 A RE RA ++ AEG+++A A++EA QA Sbjct: 209 AEAAREARAKVVAAEGEQKASRALKEAADVIQA 241 >pir||T27365 hypothetical protein Y71H9A.2 - Caenorhabditis elegans >gi|3881292|emb|CAA21750.1| (AL032659) predicted using Genefinder~contains similarity to Pfam domain: PF01145 (SPFH domain / Band 7 family), Score=350.2, E-value=7.4e-102, N=1 [Caenorhabditis elegans] Length = 298 Score = 140 bits (350), Expect = 2e-32 Identities = 77/197 (39%), Positives = 119/197 (60%), Gaps = 2/197 (1%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERVKVVDLREH 68 I+ + L I + L VKV + Y++ ++ RLG+ PG+ F++P ++ K +DLR Sbjct: 41 ILAVLTLPISVFLCVKVAQEYERAVIFRLGRVKPGGARGPGLFFVVPCIDSYKKIDLRTL 100 Query: 69 VIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEME 128 +VPPQE++ KD V V VDAVV+++I + +V N+ D + LAQT LR I+G Sbjct: 101 SFEVPPQELLSKDAVTVAVDAVVFFRISNATISVINIEDAARSTKLLAQTTLRNILGTKT 160 Query: 129 LDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRA 188 L E LS RD+I+ +++ LD+ T WGVK+ RVE++ + P +Q MA + A R+ A Sbjct: 161 LTEMLSDRDVISLQMQATLDETTIPWGVKVERVEMKDVRLPYQLQRVMAAEAEATRDAMA 220 Query: 189 MILIAEGKKEAAIREAE 205 I+ AEG+K A+ AE Sbjct: 221 KIIAAEGEKNASTALAE 237 >gi|4758276 erythrocyte membrane protein band 7.2 (stomatin) [Homo sapiens] >gi|11427638|ref|XP_005343.1| erythrocyte membrane protein band 7.2 (stomatin) [Homo sapiens] >gi|114823|sp|P27105|BAN7_HUMAN ERYTHROCYTE BAND 7 INTEGRAL MEMBRANE PROTEIN (STOMATIN) (PROTEIN 7.2B) >gi|88143|pir||S17659 membrane protein 7, erythrocyte - human >gi|31069|emb|CAA42671.1| (X60067) erythrocyte band 7 integral membrane protein [Homo sapiens] >gi|1161562|emb|CAA59436.1| (X85116) stomatin [Homo sapiens] >gi|1586566|prf||2204264A band 7 integral membrane protein [Homo sapiens] Length = 288 Score = 140 bits (349), Expect = 2e-32 Identities = 73/190 (38%), Positives = 117/190 (61%), Gaps = 4/190 (2%) Query: 19 IMLLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERVKVVDLREHVIDVPPQE 76 I + + +K+I+ Y++ ++ RLG+ + PG+ FI+P + VD+R D+PPQE Sbjct: 48 ISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQE 107 Query: 77 VICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGR 136 ++ KD+V ++VD VVYY++ + AV N+++ A LAQT LR ++G L + LS R Sbjct: 108 ILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDR 167 Query: 137 DIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGK 196 + I ++ LD TD WG+K+ RVEI+ + P +Q AMA + A RE RA ++ AEG+ Sbjct: 168 EEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGE 227 Query: 197 KEA--AIREA 204 A A++EA Sbjct: 228 MNASRALKEA 237 >gb|AAA58432.1| (M81635) stomatin peptide [Homo sapiens] Length = 288 Score = 140 bits (349), Expect = 2e-32 Identities = 73/190 (38%), Positives = 117/190 (61%), Gaps = 4/190 (2%) Query: 19 IMLLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERVKVVDLREHVIDVPPQE 76 I + + +K+I+ Y++ ++ RLG+ + PG+ FI+P + VD+R D+PPQE Sbjct: 48 ISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQE 107 Query: 77 VICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGR 136 ++ KD+V ++VD VVYY++ + AV N+++ A LAQT LR ++G L + LS R Sbjct: 108 ILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDR 167 Query: 137 DIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGK 196 + I ++ LD TD WG+K+ RVEI+ + P +Q AMA + A RE RA ++ AEG+ Sbjct: 168 EEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGE 227 Query: 197 KEA--AIREA 204 A A++EA Sbjct: 228 MNASRALKEA 237 >gb|AAC50296.1| (U33931) band 7.2b stomatin [Homo sapiens] >gi|1585683|prf||2201444A membrane protein band 7.2b [Homo sapiens] Length = 296 Score = 140 bits (349), Expect = 2e-32 Identities = 73/190 (38%), Positives = 117/190 (61%), Gaps = 4/190 (2%) Query: 19 IMLLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERVKVVDLREHVIDVPPQE 76 I + + +K+I+ Y++ ++ RLG+ + PG+ FI+P + VD+R D+PPQE Sbjct: 56 ISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQE 115 Query: 77 VICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGR 136 ++ KD+V ++VD VVYY++ + AV N+++ A LAQT LR ++G L + LS R Sbjct: 116 ILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDR 175 Query: 137 DIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGK 196 + I ++ LD TD WG+K+ RVEI+ + P +Q AMA + A RE RA ++ AEG+ Sbjct: 176 EEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGE 235 Query: 197 KEA--AIREA 204 A A++EA Sbjct: 236 MNASRALKEA 245 >sp|P54116|BAN7_MOUSE ERYTHROCYTE BAND 7 INTEGRAL MEMBRANE PROTEIN (STOMATIN) (PROTEIN 7.2B) Length = 284 Score = 139 bits (346), Expect = 5e-32 Identities = 78/209 (37%), Positives = 125/209 (59%), Gaps = 8/209 (3%) Query: 4 SAGGVALIILGIFLLIMLLLSV----KVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFM 57 + G + + + IF+LI +S+ K+++ Y++ ++ RLG+ + PG+ FI+P Sbjct: 29 ACGWILVAVSFIFVLITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILPCT 88 Query: 58 ERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQ 117 + VD+R D+PPQEV+ KD+V ++VD VVYY++ + AV N+++ A LAQ Sbjct: 89 DSFIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQ 148 Query: 118 TNLRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMA 177 T LR +G L + LS R+ I ++ LD TD WG+K+ RVEI+ + P +Q AMA Sbjct: 149 TTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMA 208 Query: 178 KQMTAEREKRAMILIAEGKKEA--AIREA 204 + A RE RA ++ AEG+ A A++EA Sbjct: 209 AEAEAAREARAKVIAAEGEMNASRALKEA 237 >pir||JC5221 stomatin - mouse >gi|975689|emb|CAA62503.1| (X91043) erthyrocyte band 7 integral membrane protein, protein 7.2B, stomatin [Mus musculus] Length = 284 Score = 139 bits (346), Expect = 5e-32 Identities = 78/209 (37%), Positives = 125/209 (59%), Gaps = 8/209 (3%) Query: 4 SAGGVALIILGIFLLIMLLLSV----KVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFM 57 + G + + + IF+LI +S+ K+++ Y++ ++ RLG+ + PG+ FI+P Sbjct: 29 ACGWILVAVSFIFVLITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILPCT 88 Query: 58 ERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQ 117 + VD+R D+PPQEV+ KD+V ++VD VVYY++ + AV N+++ A LAQ Sbjct: 89 DSFIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQ 148 Query: 118 TNLRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMA 177 T LR +G L + LS R+ I ++ LD TD WG+K+ RVEI+ + P +Q AMA Sbjct: 149 TTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMA 208 Query: 178 KQMTAEREKRAMILIAEGKKEA--AIREA 204 + A RE RA ++ AEG+ A A++EA Sbjct: 209 AEAEAAREARAKVIAAEGEMNASRALKEA 237 >sp|Q19958|STO2_CAEEL STO-2 PROTEIN >gi|7500297|pir||T16240 hypothetical protein F32A6.5 - Caenorhabditis elegans >gi|1065452|gb|AAA81390.1| (U40409) similar C. elegans stomatin-like protein MEC-2, Genbank accession # U26735, and to erythrocyte band 7 integral membrane protein SP:BAN7_HUMAN [Caenorhabditis elegans] Length = 280 Score = 139 bits (346), Expect = 5e-32 Identities = 76/202 (37%), Positives = 124/202 (60%), Gaps = 4/202 (1%) Query: 7 GVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKF--NRLLDPGIHFIIPFMERVKVVD 64 G++ I++ + + +KV++ Y++ ++ RLG+ PGI F++P +E VD Sbjct: 41 GLSWIMVISTFPVSIYFCMKVVQEYERAVIFRLGRLIGGGAKGPGIFFVLPCIESYTKVD 100 Query: 65 LREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAII 124 LR VPPQE++ KD+V +VDAV+YY+I + +V NV + + LAQT LR ++ Sbjct: 101 LRTVSFSVPPQEILTKDSVTTSVDAVIYYRISNATVSVANVENAHHSTRLLAQTTLRNML 160 Query: 125 GEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAER 184 G L E LS R+ + A ++ LD+ T+ WG+K+ RVEI+ + P +Q AMA + A R Sbjct: 161 GTRSLSEILSDRETLAASMQTILDEATESWGIKVERVEIKDVRLPIQLQRAMAAEAEATR 220 Query: 185 EKRAMILIAEGKKEA--AIREA 204 E RA ++ AEG+++A A+R+A Sbjct: 221 EARAKVIAAEGEQKASRALRDA 242 >gi|7710018 erythrocyte protein band 7.2; protein 7.2b [Mus musculus] >gi|972907|gb|AAA75024.1| (U17297) integral membrane phosphoprotein band 7.2b [Mus musculus] >gi|1582614|prf||2119189A band 7.2b protein [Mus musculus] Length = 284 Score = 138 bits (344), Expect = 8e-32 Identities = 77/211 (36%), Positives = 125/211 (58%), Gaps = 9/211 (4%) Query: 3 ISAGGVALIILGIFLLIM-----LLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIP 55 + A G L+ F +I+ + + +K+++ Y++ ++ RLG+ + PG+ FI+P Sbjct: 27 LGACGWILVAASFFFVIITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILP 86 Query: 56 FMERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKL 115 + + VD+R D+PPQEV+ KD+V ++VD VVYY++ + AV N+++ A L Sbjct: 87 CTDSLIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLL 146 Query: 116 AQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEA 175 AQT LR +G L + LS R+ I ++ LD TD WG+K+ RVEI+ + P +Q A Sbjct: 147 AQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRA 206 Query: 176 MAKQMTAEREKRAMILIAEGKKEA--AIREA 204 MA + A RE RA ++ AEG+ A A++EA Sbjct: 207 MAAEAEAAREARAKVIAAEGEMNASRALKEA 237 >gb|AAC64173.1| (AF093620) stomatin [Mus musculus] Length = 284 Score = 138 bits (344), Expect = 8e-32 Identities = 77/211 (36%), Positives = 125/211 (58%), Gaps = 9/211 (4%) Query: 3 ISAGGVALIILGIFLLIM-----LLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIP 55 + A G L+ F +I+ + + +K+++ Y++ ++ RLG+ + PG+ FI+P Sbjct: 27 LGACGWILVAASFFFVIITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILP 86 Query: 56 FMERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKL 115 + + VD+R D+PPQEV+ KD+V ++VD VVYY++ + AV N+++ A L Sbjct: 87 CTDSLIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLL 146 Query: 116 AQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEA 175 AQT LR +G L + LS R+ I ++ LD TD WG+K+ RVEI+ + P +Q A Sbjct: 147 AQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRA 206 Query: 176 MAKQMTAEREKRAMILIAEGKKEA--AIREA 204 MA + A RE RA ++ AEG+ A A++EA Sbjct: 207 MAAEAEAAREARAKVIAAEGEMNASRALKEA 237 >sp|Q20657|STO3_CAEEL STO-3 PROTEIN >gi|7503947|pir||T22502 hypothetical protein F52D10.5 - Caenorhabditis elegans >gi|3877420|emb|CAA91476.1| (Z66564) contains similarity to Pfam domain: PF01145 (SPFH domain / Band 7 family), Score=393.1, E-value=8.8e-115, N=1 [Caenorhabditis elegans] Length = 267 Score = 130 bits (323), Expect = 2e-29 Identities = 73/200 (36%), Positives = 123/200 (61%), Gaps = 6/200 (3%) Query: 8 VALIILGIFLLIMLLLS----VKVIRPYQKGLVERLGKF--NRLLDPGIHFIIPFMERVK 61 VALI FLL+ +S VK+++ Y + ++ RLG+ + PGI ++PF++ K Sbjct: 18 VALICAWAFLLLTFPVSIFFCVKIVKEYDRMVIFRLGRLWQDNPRGPGIVLVLPFIDSHK 77 Query: 62 VVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLR 121 VDLR DVP QE++ +D+V + VDA VYY+ DP+ ++ V+D M+ +LAQ++LR Sbjct: 78 TVDLRVMSYDVPTQEMLTRDSVTIGVDAAVYYRTSDPIASLARVNDAHMSTRQLAQSSLR 137 Query: 122 AIIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMT 181 ++G L E ++ R I +++ LD T WG+ + RVEI+ I P+++ AMA + Sbjct: 138 NVLGTRSLAELMTDRHGIAVQVKYILDSATLFWGIHVERVEIKDIRLPREMCRAMAAEAE 197 Query: 182 AEREKRAMILIAEGKKEAAI 201 A+RE A ++ A+G+ +A++ Sbjct: 198 AQRESDAKVVTAQGELDASM 217 >gb|AAF54746.1| (AE003694) CG14736 gene product [Drosophila melanogaster] Length = 368 Score = 122 bits (304), Expect = 4e-27 Identities = 64/173 (36%), Positives = 109/173 (62%), Gaps = 3/173 (1%) Query: 35 LVERLGKFNR-LLDPGIHFIIPFMERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 ++ RLG+ + L PG+ FI+P ++ VD+R V +V PQ+V+ KD+V +TV+AVVYY Sbjct: 2 IILRLGRLRKGLRGPGLVFILPCIDETHRVDMRTDVTNVRPQDVLTKDSVTITVNAVVYY 61 Query: 94 QILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKITDR 153 I P+ ++ V D A ++Q LR I+G L+ L+ R ++ ++++ + IT R Sbjct: 62 CIYSPIDSIIQVDDAKQATQLISQVTLRNIVGSKTLNVLLTSRQQLSREIQQAVAGITYR 121 Query: 154 WGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEA--AIREA 204 WGV++ RV++ I P ++ ++A + A RE RA I++AEG+ +A A++EA Sbjct: 122 WGVRVERVDVMDITLPTSLERSLASEAEAVREARAKIILAEGELKASKALKEA 174 >gb|AAF52157.1| (AE003607) CG14644 gene product [Drosophila melanogaster] Length = 225 Score = 113 bits (279), Expect = 3e-24 Identities = 60/178 (33%), Positives = 106/178 (58%), Gaps = 4/178 (2%) Query: 31 YQKGLVERLGKFNRL--LDPGIHFIIPFMERVKVVDLREHVIDVPPQEVICKDNVVVTVD 88 Y++ ++ RLG+ PG+ F++P ++ + VVD+R D+ QE++ +D V +++D Sbjct: 4 YERAVILRLGRLRPKPPRGPGVIFLVPCIDDLAVVDIRTRSFDLHRQEILTRDMVTISID 63 Query: 89 AVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELD 148 VVYY I P A+ V D A KLA T LR + G +L + LS ++ ++ ++ L Sbjct: 64 GVVYYSIKSPFDAMLQVYDPEEATEKLAMTTLRNVAGTHKLMDLLSSKEYLSNQIEGILY 123 Query: 149 KITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEA--AIREA 204 T+ WG+++ RVEI+ I P ++ A+A + A RE +A + A+G+++A A++EA Sbjct: 124 NSTEPWGIRVERVEIKEIFMPDQLKRALAVEQEAMREAKAKVAAAQGERDAVTALKEA 181 >gi|7657615 podocin [Homo sapiens] >gi|7363002|emb|CAB83216.1| (AJ279254) podocin [Homo sapiens] >gi|7363472|emb|CAB83272.1| (AJ279246) podocin [Homo sapiens] Length = 383 Score = 106 bits (261), Expect = 4e-22 Identities = 54/198 (27%), Positives = 109/198 (54%), Gaps = 7/198 (3%) Query: 10 LIILGIFLLIM-----LLLSVKVIRPYQKGLVERLGKF--NRLLDPGIHFIIPFMERVKV 62 L+++ + +IM + VKV++ Y++ ++ RLG R PG+ F +P ++ Sbjct: 105 LVLISLLFIIMTFPFSIWFCVKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHK 164 Query: 63 VDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRA 122 VDLR +++P E++ KD ++ +DA+ YY++ + + +++ A+ L QT ++ Sbjct: 165 VDLRLQTLEIPFHEIVTKDMFIMEIDAICYYRMENASLLLSSLAHVSKAVQFLVQTTMKR 224 Query: 123 IIGEMELDETLSGRDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTA 182 ++ L E L R I + LD +T WG+K+ R+EI+ + P +Q ++A + A Sbjct: 225 LLAHRSLTEILLERKSIAQDAKVALDSVTCIWGIKVERIEIKDVRLPAGLQHSLAVEAEA 284 Query: 183 EREKRAMILIAEGKKEAA 200 +R+ + ++ AE +K A+ Sbjct: 285 QRQAKVRMIAAEAEKAAS 302 >pir||E82334 hflK protein VC0349 [imported] - Vibrio cholerae (group O1 strain N16961) >gi|9654765|gb|AAF93522.1| (AE004123) hflK protein [Vibrio cholerae] Length = 395 Score = 102 bits (251), Expect = 6e-21 Identities = 78/281 (27%), Positives = 141/281 (49%), Gaps = 9/281 (3%) Query: 5 AGGVAL---IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVK 61 +GG A+ +I I + + I ++G+V RLGK++R++DPG+++ F++ V Sbjct: 64 SGGGAIGFGVIAAIAVAVWFFTGFYTIGEAERGVVLRLGKYDRIVDPGLNWRPRFIDEVT 123 Query: 62 VVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLR 121 V+++ ++ KD VVTV V Y+I DP K +Y V++ ++ + + LR Sbjct: 124 PVNVQAIRSLRASGLMLTKDENVVTVSMDVQYRIADPYKYLYRVTNADDSLRQATDSALR 183 Query: 122 AIIGEMELDETL-SGRDIINAKLREELDKITDRW--GVKITRVEIQRIDPPKDIQEAMAK 178 A++G+ +D L SGR I ++ L+++ D + G+ I V Q PP+ +++A Sbjct: 184 AVVGDSLMDSILTSGRQQIRQSTQQTLNQVIDSYDMGLMIVDVNFQSARPPEQVKDAFDD 243 Query: 179 QMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLE 238 + A ++ I AE K + +A G+ + +A+G +R I A GQ K+L Sbjct: 244 AIAAREDEERFIREAEAYKNEILPKATGRAERLKKEAQGYNERTINEALGQVAQFEKLLP 303 Query: 239 ALKMADEKYLTLQYIEKLPDLAKYGNLI-VPYDTESLIGLL 278 + A + Y++ + + Y N V D+ES LL Sbjct: 304 EYQAAPKVTRDRLYLDAMEQV--YSNTSKVLIDSESSGNLL 342 >sp|P40605|HFLK_VIBPA HFLK PROTEIN >gi|507734|gb|AAA62186.1| (U09005) HflK [Vibrio parahaemolyticus] Length = 400 Score = 101 bits (249), Expect = 1e-20 Identities = 84/302 (27%), Positives = 150/302 (48%), Gaps = 10/302 (3%) Query: 3 ISAGGVAL---IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMER 59 I GG A+ +I I + + + I ++G+V RLGK++R++DPG+++ F++ Sbjct: 65 IGGGGGAIGFGVIAIIAIAVWIFAGFYTIGEAERGVVLRLGKYDRIVDPGLNWRPRFIDE 124 Query: 60 VKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTN 119 + V+++ ++ KD VVTV V Y++ DP K +Y V++ ++ + + Sbjct: 125 YEAVNVQAIRSLRASGLMLTKDENVVTVAMDVQYRVADPYKYLYRVTNADDSLRQATDSA 184 Query: 120 LRAIIGEMELDETL-SGRDIINAKLREELDKITDRW--GVKITRVEIQRIDPPKDIQEAM 176 LRA+IG+ +D L SGR I +E L++I D + G+ I V Q PP+ +++A Sbjct: 185 LRAVIGDSLMDSILTSGRQQIRQSTQETLNQIIDSYDMGLVIVDVNFQSARPPEQVKDAF 244 Query: 177 AKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKV 236 + A ++ I AE K + +A G+ + +A+G +R A GQ K+ Sbjct: 245 DDAIAAREDEERFIREAEAYKNEILPKATGRAERLKKEAQGYNERVTNEALGQVAQFEKL 304 Query: 237 LEALKMADEKYLTLQYIEKLPDLAKYGNLI-VPYDTESLIGLLRV-LQKVKSIPLQQSTE 294 L + A YI+ + ++ Y N V D+ES LL + + K+ Q T+ Sbjct: 305 LPEYQAAPGVTRDRLYIDAMEEV--YTNTSKVLIDSESSGNLLYLPIDKLAGQEGQTDTK 362 Query: 295 KK 296 +K Sbjct: 363 RK 364 >gb|AAB18857.1| (U50999) stomatin [Mus musculus] Length = 259 Score = 100 bits (247), Expect = 2e-20 Identities = 64/185 (34%), Positives = 101/185 (54%), Gaps = 15/185 (8%) Query: 24 SVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERVKVVDLREHVIDVPPQEVICKD 81 S +++ Y++ ++ RLG+ + PG+ F+ R R V+ KD Sbjct: 39 SFSIVKEYERVIIFRLGRILQGGAKGPGVCFLSC---RALTASSR--------WTVLTKD 87 Query: 82 NVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINA 141 +V ++VD VVYY++ + AV N+++ A LAQT LR +G L + LS R+ I Sbjct: 88 SVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAH 147 Query: 142 KLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEA-- 199 ++ LD TD WG+K+ RVEI+ + P +Q AMA + A RE RA ++ AEG+ A Sbjct: 148 HMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASR 207 Query: 200 AIREA 204 A++EA Sbjct: 208 ALKEA 212 >pir||B72207 ftsH proteinase activity modulator HflC - Thermotoga maritima (strain MSB8) >gi|4982405|gb|AAD36886.1|AE001819_9 (AE001819) ftsH protease activity modulator HflC [Thermotoga maritima] Length = 283 Score = 100 bits (247), Expect = 2e-20 Identities = 75/271 (27%), Positives = 139/271 (50%), Gaps = 8/271 (2%) Query: 10 LIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRL-LDPGIHFIIPFMERVKVVDLREH 68 LIIL + I+L S V+ Q+ +V R GK + +PG+HF PF++ V D R Sbjct: 9 LIILIVVGAILLFSSFYVLDQTQQAVVLRFGKIVAVETEPGLHFKQPFVDNVVRFDKRIL 68 Query: 69 VIDVPPQEVICKDNVVVTVDAVVYYQILDP---VKAVYNVSDFLMAIVKLAQTNLRAIIG 125 + D+ P+++I D + +D V ++I D +K++ +V L I + +++R I Sbjct: 69 LYDIEPEKIIAADKKTLVIDTYVLWRIKDAEAFIKSLKSVKLALPRIDDVVYSHVRNIFA 128 Query: 126 EMELDETLSGR--DIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAE 183 + DE +S + D++ + + D +G+++ V ++ D P + ++A+ ++M AE Sbjct: 129 KANFDEIISEKREDLLREVTALSREDLKD-FGIEVVDVRVKHADLPAENEKAVYERMKAE 187 Query: 184 REKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMA 243 R A + AEG+KEA AE K A +L AE + + + + G+A A++ E Sbjct: 188 RYSIAAQIRAEGEKEARKIRAEADKTAKVLIAEAQSKAEQIKGTGEASAVKIYAEVFSKD 247 Query: 244 DEKYLTLQYIEKLPDLAKYGNLIVPYDTESL 274 + Y + +E + K G LI+ + ++L Sbjct: 248 KDFYEFWRTMEVYRSIEK-GILIIGDELDAL 277 >pir||A82806 integral membrane proteinase XF0452 [imported] - Xylella fastidiosa (strain 9a5c) >gi|9105296|gb|AAF83262.1|AE003895_13 (AE003895) integral membrane protease [Xylella fastidiosa] Length = 379 Score = 99.1 bits (243), Expect = 6e-20 Identities = 72/280 (25%), Positives = 137/280 (48%), Gaps = 10/280 (3%) Query: 2 MISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPF----M 57 + AG + +++G+ LLI++ S+++I Q+G+V R G+F R+L PG+ +P+ + Sbjct: 43 LFDAGILIWVLIGV-LLIVVFSSIQLIGEQQRGVVLRFGQFVRVLQPGLSLKLPWPVESV 101 Query: 58 ERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQ 117 +V +++ VP V+ +D +V V V YQI DP +Y + +V+ AQ Sbjct: 102 YKVNATEIKTFGKQVP---VLTRDENIVNVTLNVQYQINDPHLYLYGSRNANEVLVQAAQ 158 Query: 118 TNLRAIIGEMELDETLSGRDIINAKLREELDKITD--RWGVKITRVEIQRIDPPKDIQEA 175 + +R +G +L+ L+ R ++ +E L D R G+ +T + + PP++++ A Sbjct: 159 SAVREQVGRSDLNSVLNNRGPLSTASKERLQASLDAYRTGLLVTGLTLPDARPPEEVKSA 218 Query: 176 MAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRK 235 + A++ + +I A+ + EA G+ + AEG KQ I A+G A+ Sbjct: 219 FDEVNGAQQVRERLIDEAQAYAAKVVPEARGRAASNRTAAEGYKQAVIARAQGDADRFTL 278 Query: 236 VLEALKMADEKYLTLQYIEKLPDLAKYGNLIVPYDTESLI 275 + K A E ++E + + ++ D LI Sbjct: 279 LQAQYKNAPEVTRKRLWLETIQQVLAQNRKVIGADGRQLI 318 >sp|P25662|HFLK_ECOLI HFLK PROTEIN >gi|280067|pir||B43653 probable integral membrane proteinase (EC 3.4.-.-) hflK - Escherichia coli >gi|436157|gb|AAC43399.1| (U00005) putative integral membrane protein required for high frequency lysogenization by bacteriophage lambda [Escherichia coli] >gi|537015|gb|AAA97070.1| (U14003) CG Site No. 639; alternate gene name hflA; putative integral membrane protease required for high frequency lysogenization by bacteriophage lambda [Escherichia coli] >gi|1790616|gb|AAC77131.1| (AE000489) protease specific for phage lambda cII repressor [Escherichia coli K12] Length = 419 Score = 97.1 bits (238), Expect = 2e-19 Identities = 70/255 (27%), Positives = 128/255 (49%), Gaps = 5/255 (1%) Query: 6 GGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDL 65 G V I ++I I+ ++G+V R GKF+ L++PG+++ F++ VK V++ Sbjct: 78 GRVVTIAAAAIVIIWAASGFYTIKEAERGVVTRFGKFSHLVEPGLNWKPTFIDEVKPVNV 137 Query: 66 REHVIDVPPQEV-ICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAII 124 E V ++ V + D VV V+ V Y++ +P K +Y+V+ ++ + + LR +I Sbjct: 138 -EAVRELAASGVMLTSDENVVRVEMNVQYRVTNPEKYLYSVTSPDDSLRQATDSALRGVI 196 Query: 125 GEMELDETLS-GRDIINAKLREELDKITDRWGVKITRVEI--QRIDPPKDIQEAMAKQMT 181 G+ +D L+ GR +I + + EL++ + + IT +++ Q PP++++ A + Sbjct: 197 GKYTMDRILTEGRTVIRSDTQRELEETIRPYDMGITLLDVNFQAARPPEEVKAAFDDAIA 256 Query: 182 AEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALK 241 A ++ I AE A GQ Q + +A K + IL A+G+ K+L K Sbjct: 257 ARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKAQTILEAQGEVARFAKLLPEYK 316 Query: 242 MADEKYLTLQYIEKL 256 A E YIE + Sbjct: 317 AAPEITRERLYIETM 331 >pir||B83028 proteinase subunit HflK PA4942 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9951222|gb|AAG08327.1|AE004907_5 (AE004907) protease subunit HflK [Pseudomonas aeruginosa] Length = 400 Score = 97.1 bits (238), Expect = 2e-19 Identities = 65/259 (25%), Positives = 130/259 (50%), Gaps = 5/259 (1%) Query: 6 GGVALIILGIFLLIMLLL--SVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVV 63 GG+ L +G+ +L +L L ++ V+ ++ ++ R GK+ + PG++F P +++ Sbjct: 71 GGLGLFGIGLAILAVLWLYNAIYVVDEQEQAVILRFGKYYETVGPGLNFYFPPIDKRFQE 130 Query: 64 DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAI 123 ++ +++ +D +V V V Y+I + V NV +++ + ++ LR + Sbjct: 131 NVTRERAYSKQGQMLTEDENIVEVPLTVQYKISNLQDFVLNVDQPEVSLQQATESALRHV 190 Query: 124 IGEMELDETLS-GRDIINAKLREELDKITD--RWGVKITRVEIQRIDPPKDIQEAMAKQM 180 G +D L+ GR+ + ++RE L + D R G+ +T+V IQ P+++QEA + Sbjct: 191 AGSTTMDRILTEGREQMATEVRERLQRFLDTYRTGITVTQVNIQSAQAPREVQEAFDDVI 250 Query: 181 TAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEAL 240 A +++ AE + EA GQ Q I +A G + I A+G+A+ K+L Sbjct: 251 RAREDEQREKNQAEAYANGVVPEARGQAQRIIEEANGYRDEVISRAQGEADRFSKLLVEY 310 Query: 241 KMADEKYLTLQYIEKLPDL 259 + A E Y++ + ++ Sbjct: 311 RKAPEVTRERLYLDTMQEV 329 >pir||A72207 ftsH proteinase activity modulator HflK - Thermotoga maritima (strain MSB8) >gi|4982404|gb|AAD36885.1|AE001819_8 (AE001819) ftsH protease activity modulator HflK [Thermotoga maritima] Length = 308 Score = 96.7 bits (237), Expect = 3e-19 Identities = 82/305 (26%), Positives = 143/305 (46%), Gaps = 31/305 (10%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMER----VKVV 63 V I+LGI+ L V + P + L++ G+F ++ GIH+ +P+ + V V Sbjct: 8 VVFIVLGIYFLT----GVYQVGPSEVALLKTFGRFTSVVPSGIHYHLPYPIQSHVTVDVT 63 Query: 64 DLREHVI-------------DVPPQE--VICKDNVVVTVDAVVYYQILDPVKAVYNVSDF 108 +R+ I PQE +I DN +V+V+AVV Y++ DPV +N+++ Sbjct: 64 TVRKIEIGFRSIQRGERISYQSVPQEAIMITGDNNLVSVEAVVQYRVKDPVAYAFNITEA 123 Query: 109 LMAIVKLAQTNLRAIIGEMELDETL-SGRDIINAKLREELDKITDRW--GVKITRVEIQR 165 + ++ LR + +D+ L SGRD I K + L +I D + G+K+ V +Q Sbjct: 124 DSIVRFTTESVLREKVAMRSIDDVLTSGRDEIGFKTAQMLQEILDSYNCGIKVENVYLQE 183 Query: 166 IDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILI 225 + PP + +A A ++K +I A + +A+GQ Q + +AE Q L Sbjct: 184 VVPPDPVVDAFDDVNNARQDKERLINEARKYANDVVPKAQGQAQEILRQAEAYAQEVYLK 243 Query: 226 AEGQAEAIRKVLEALKMADE---KYLTLQYIEKLPDLAKYGNLIVPYDTESLIGLLRVLQ 282 A G+A+ +VLE A + K + L ++ L L K N + + +L + Sbjct: 244 ALGEAKRFEEVLEEYSKAPDITRKRMLLDALQSL--LEKSENKVFFVGNGDSLNILNISD 301 Query: 283 KVKSI 287 +K + Sbjct: 302 LLKGM 306 >dbj|BAB06873.1| (AP001517) protease specific for phage lambda cII repressor [Bacillus halodurans] Length = 310 Score = 95.2 bits (233), Expect = 8e-19 Identities = 73/289 (25%), Positives = 144/289 (49%), Gaps = 24/289 (8%) Query: 3 ISAGGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRL-LDPGIHFIIPFMERVK 61 + G VA++++GI +I L ++ ++ + +V + G+ R+ +PG+ F IPF++ V Sbjct: 22 VQLGSVAVLLIGIVGII--LSNLFIVEQGEYKVVRQFGEVVRVESEPGLKFKIPFIQSVS 79 Query: 62 VVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQ---T 118 + + + D+PP E+ +D + D ++I DP++ + NV A L + + Sbjct: 80 TLPKYQMIYDIPPAEINTRDKKRMMADHYALWRIEDPLRMISNVGSLQGAEAILGEQIFS 139 Query: 119 NLRAIIGEMELDETL----SGRDIINAKLREELDKITDR--WGVKITRVEIQRIDPPKDI 172 +RA +G++E E + + R N +++E ++ +R G+ + V ++R D PK+ Sbjct: 140 AIRAELGQLEFGEIINEEENSRGDFNQQVKERVNSSLERQDLGIVLLDVRMKRTDLPKEN 199 Query: 173 QEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEA 232 +EA+ ++M +ERE A +++G EA A ++ + A+ + + +I G+AEA Sbjct: 200 EEAVYRRMISERESIAQDYLSQGDAEANRIRARTDQEVTEILAKAKADAEEIIGAGEAEA 259 Query: 233 IRKVLEALKMADE---KYLTLQYIEK---------LPDLAKYGNLIVPY 269 E+ E Y TL EK LP + Y +++ Y Sbjct: 260 AEIYNESFGRDPEFYQLYRTLLSYEKTIGDQTVIVLPADSPYARILMGY 308 >pir||A71722 hflC protein (hflC) RP123 - Rickettsia prowazekii >gi|3860691|emb|CAA14592.1| (AJ235270) HFLC PROTEIN (hflC) [Rickettsia prowazekii] Length = 286 Score = 94.0 bits (230), Expect = 2e-18 Identities = 72/270 (26%), Positives = 133/270 (48%), Gaps = 14/270 (5%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLD-PGIHFIIPFMERVKVVDLREHV 69 I+ G+ L+ L SV Q +V + G+ R ++ PG++ IPF++ V+ D R Sbjct: 12 IVFGLMLIASALFSVD---QRQSAVVFQFGEAIRTIENPGLNIKIPFIQNVEFFDKRLLD 68 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLA---QTNLRAIIGE 126 ++V +E+ D V VDA +QI +PV V D+ ++L ++++R +IG+ Sbjct: 69 VEVEAKELTAADGKRVIVDAYAKFQINNPVMFYKTVHDYQGVKIRLTRNLESSMRKVIGK 128 Query: 127 MELDETLSG-RDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAERE 185 + L LS R + + +++ +G+ + V I R D PK+ A+ ++M RE Sbjct: 129 ISLSSLLSQERSNVMLNILNQVNGEAKSFGIDVVDVRILRADLPKENSAAIYRRMQTARE 188 Query: 186 KRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMADE 245 K A + AEG++E+ ++ K++ I+ A+ + QI+ +G +A K+ A D Sbjct: 189 KEATQIRAEGQEESVRIRSKADKESKIILAKAYRDAQIIKGDGDEKA-AKIYNAAYSVDP 247 Query: 246 KYLTLQYIEKLPDLAKYGNLIVPYDTESLI 275 ++ + L Y N + DT +I Sbjct: 248 -----EFYKFYRSLLVYKNALKKEDTNFVI 272 >pir||A83028 proteinase subunit HflC PA4941 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9951221|gb|AAG08326.1|AE004907_4 (AE004907) protease subunit HflC [Pseudomonas aeruginosa] Length = 289 Score = 92.4 bits (226), Expect = 5e-18 Identities = 60/230 (26%), Positives = 121/230 (52%), Gaps = 20/230 (8%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRL-LDPGIHFIIPFMERVKVVDLREHV 69 +I+G+ I+L SV V++ ++ ++ R G+ + PG+HF IP++ +V+ D R Sbjct: 9 LIVGVVAAIVLWNSVYVVQQTERAVMLRFGRVVESDVKPGLHFKIPYVNQVRKFDARLLT 68 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIV-----KLAQTNLRAII 124 +D P Q + + V VDA +++ D + Y + L I + + LR Sbjct: 69 LDAPTQRFLTLEKKAVMVDAYAKWRVAD-AERFYTATSGLKQIADERLSRRLEAGLRDQF 127 Query: 125 GEMELDETLSG-RDIINAKLREELDKITDR-WGVKITRVEIQRIDPPKDIQEAMAKQMTA 182 G+ L E +SG RD + + L+++ + G+++ V ++ ID PK++ ++ ++M+ Sbjct: 128 GKRTLHEVVSGERDALMGDITASLNRMAQKELGIEVIDVRVKAIDLPKEVNRSVFERMST 187 Query: 183 EREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEA 232 ERE +EA A+G++ A ++A+ ++QR++++AE E+ Sbjct: 188 ERE-----------REAREHRAKGRELAEGIRADADRQRRVIVAEAYRES 226 >sp|P44546|HFLK_HAEIN HFLK PROTEIN >gi|1075179|pir||A64051 probable integral membrane proteinase (EC 3.4.-.-) hflK - Haemophilus influenzae (strain Rd KW20) >gi|1573108|gb|AAC21822.1| (U32701) hflK protein (hflK) [Haemophilus influenzae Rd] Length = 410 Score = 90.5 bits (221), Expect = 2e-17 Identities = 61/255 (23%), Positives = 135/255 (52%), Gaps = 5/255 (1%) Query: 6 GGVALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDL 65 G V + + I +I + I+ ++G+V R G+ + ++ PG+++ F+++V V++ Sbjct: 85 GKVIPLAVAIGAIIWGVNGFYTIKEAERGVVLRFGELHSIVQPGLNWKPTFVDKVLPVNV 144 Query: 66 REHVIDVPPQ-EVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAII 124 E V ++ Q ++ +D +V V+ V Y++ DP K +++V++ ++ + + LR +I Sbjct: 145 -EQVKELRTQGAMLTQDENMVKVEMTVQYRVQDPAKYLFSVTNADDSLNQATDSALRYVI 203 Query: 125 GEMELDETLS-GRDIINAKLREELDKITDRW--GVKITRVEIQRIDPPKDIQEAMAKQMT 181 G M +++ L+ GR ++ + L++I + G+++ V Q PP+++++A + Sbjct: 204 GHMSMNDILTTGRSVVRENTWKALNEIIKSYDMGLEVIDVNFQSARPPEEVKDAFDDAIK 263 Query: 182 AEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALK 241 A+ +++ I AE A G Q + +A K R +L A+G+ E ++++L K Sbjct: 264 AQEDEQRFIREAEAYAREKEPIARGDAQRILEEATAYKDRIVLDAKGEVERLQRLLPEFK 323 Query: 242 MADEKYLTLQYIEKL 256 A + YI+ + Sbjct: 324 AAPDLLRERLYIQTM 338 >gb|AAF47921.1| (AE003481) CG7468 gene product [Drosophila melanogaster] Length = 382 Score = 90.1 bits (220), Expect = 3e-17 Identities = 50/126 (39%), Positives = 76/126 (59%), Gaps = 2/126 (1%) Query: 21 LLLSVKVIRPYQKGLVERLGKFNR--LLDPGIHFIIPFMERVKVVDLREHVIDVPPQEVI 78 L + KV++ Y++ ++ RLG+ + PGI FI+P ++ VDLR DVPPQEV+ Sbjct: 7 LFVCFKVVQEYERAVIFRLGRLMQGGAKGPGIFFILPCIDSYARVDLRTRTYDVPPQEVL 66 Query: 79 CKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDI 138 KD+V V+VDAVVYY++ + ++ NV + + LAQT LR +G L E LS R Sbjct: 67 TKDSVTVSVDAVVYYRVSNATVSIANVENAHHSTRLLAQTTLRNTMGTRHLHEILSERMT 126 Query: 139 INAKLR 144 I+ ++ Sbjct: 127 ISGTMQ 132 >sp|O51221|HFLK_BORBU HFLK PROTEIN >gi|7463666|pir||C70125 Lambda CII stability-governing protein (hflK) homolog - Lyme disease spirochete >gi|2688090|gb|AAC66586.1| (AE001130) Lambda CII stability-governing protein (hflK) [Borrelia burgdorferi] Length = 311 Score = 88.5 bits (216), Expect = 8e-17 Identities = 68/253 (26%), Positives = 127/253 (49%), Gaps = 25/253 (9%) Query: 10 LIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMER-----VKVV- 63 +II I + I+++ ++ ++ P ++ +V RLGK NR LD GIH IP +E VK+V Sbjct: 17 IIITLILISIIVIANIFIVGPSEEAIVLRLGKLNRTLDSGIHVKIPLIEEKFIVPVKIVQ 76 Query: 64 -----------DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAI 112 D+RE+ +I D ++ ++ +V Y+I DP + V D I Sbjct: 77 EIKFGFLISPSDIRENDNANDESRIITGDLNIINIEWLVQYKIRDPYSFKFKVEDPETTI 136 Query: 113 VKLAQTNLRAIIGEMELDETLSGRDI-INAKLREELDKITDRW--GVKITRVEIQRIDPP 169 +A++++ +IG+ + E ++ + I ++ +++I D + G+ + +V+I+ PP Sbjct: 137 KDIAKSSMNRLIGDNTIFEIINDNRVGITEGVKSSMNEIIDNYNLGIDVVQVQIRNALPP 196 Query: 170 K-DIQEAMAKQMTAEREKRAMILIAEGKKE--AAIREAEGQKQAAILKAEGEKQRQILIA 226 K + EA A ++K I EG+KE + + +G+ I +A G K+ +I A Sbjct: 197 KGKVYEAFEDVNIAIQDKNK--YINEGRKEFNQIVPKIKGEALKVIEEARGYKESRINNA 254 Query: 227 EGQAEAIRKVLEA 239 E +L+A Sbjct: 255 LADTEIFNAILDA 267 >sp|P25661|HFLC_ECOLI HFLC PROTEIN >gi|280066|pir||C43653 probable integral membrane proteinase (EC 3.4.-.-) hflC - Escherichia coli >gi|436158|gb|AAC43400.1| (U00005) putative integral membrane protease required for high frequency lysogenization by bacteriophage lambda [Escherichia coli] >gi|537016|gb|AAA97071.1| (U14003) CG Site No. 17520; alternate gene name hflA; putative integral membrane protease required for high frequency lysogenization by bacteriophage lambda [Escherichia coli] >gi|1790617|gb|AAC77132.1| (AE000489) protease specific for phage lambda cII repressor [Escherichia coli K12] Length = 334 Score = 88.2 bits (215), Expect = 1e-16 Identities = 71/291 (24%), Positives = 133/291 (45%), Gaps = 52/291 (17%) Query: 9 ALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNR-------LLDPGIHFIIPFMERVK 61 ++I + I +L++L +SV V++ ++G+ R GK R + +PG+HF IPF+E VK Sbjct: 4 SVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVK 63 Query: 62 VVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVY-----NVSDFLMAIVKLA 116 ++D R +D + K+ + VD+ + ++I D + ++S + + + Sbjct: 64 MLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKF 123 Query: 117 QTNLRAIIGEMELDE---------TLSGRDIINAKLREELDKITD--------------- 152 LR+ IG +++ + TL RD +N+ D++T Sbjct: 124 SDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAERVT 183 Query: 153 ----------------RWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGK 196 G+++ V I++I+ P ++ EA+ +M AERE A ++G+ Sbjct: 184 AETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRSQGQ 243 Query: 197 KEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEKY 247 +EA A + AE E+Q +I+ EG AEA + +A + Y Sbjct: 244 EEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFY 294 >gi|4759148 stomatin-like protein 1 [Homo sapiens] >gi|4160546|emb|CAA76271.1| (Y16522) SLP-1 protein [Homo sapiens] Length = 394 Score = 86.6 bits (211), Expect = 3e-16 Identities = 54/175 (30%), Positives = 93/175 (52%), Gaps = 8/175 (4%) Query: 13 LGIFLLIMLL-----LSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 LG LL++ ++K++ Y++ +V RLG+ PG+ ++PF++ + VDLR Sbjct: 62 LGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRT 121 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 +VPP ++ KD V++V A V ++I DPV +V V D A AQ + + + Sbjct: 122 RAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKR 181 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEI---QRIDPPKDIQEAMAKQ 179 L E + I+ +L E++ +T WG+++ RVE+ + PP+D Q A Q Sbjct: 182 PLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSQLAQPGQ 236 >pir||T32977 unc-24 protein - Caenorhabditis elegans >gi|1353669|gb|AAB06496.1| (U42013) UNC-24 [Caenorhabditis elegans] >gi|2854188|gb|AAC02604.1| (AF045644) C. elegans UNC-24 bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein (GB:U42013) [Caenorhabditis elegans] Length = 415 Score = 85.4 bits (208), Expect = 7e-16 Identities = 53/166 (31%), Positives = 91/166 (53%), Gaps = 2/166 (1%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 V+ + + + + + LL ++K I +K +V RLG+ + PGI +IP ++ V + Sbjct: 71 VSFLFVVMTMPLSLLFALKFISTSEKLVVLRLGRAQKTRGPGITLVIPCIDTTHKVTMSI 130 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 +VPP ++I D +V + A V+ +I DP+ AV V D ++ LA T L I + Sbjct: 131 TAFNVPPLQIITTDRGLVELGATVFLKIRDPIAAVCGVQDRNASVRTLANTMLYRYISKK 190 Query: 128 ELDETLSGRD--IINAKLREELDKITDRWGVKITRVEIQRIDPPKD 171 + + S +D II+A L++EL T ++GV+IT VEI + K+ Sbjct: 191 RICDVTSSQDRRIISANLKDELGSFTCQFGVEITDVEISDVKIVKE 236 >sp|P57631|HFLK_BUCAI HFLK PROTEIN >gi|10039224|dbj|BAB13258.1| (AP001119) hflK protein [Buchnera sp. APS] Length = 406 Score = 85.4 bits (208), Expect = 7e-16 Identities = 64/255 (25%), Positives = 122/255 (47%), Gaps = 5/255 (1%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLREHVI 70 II+ I I + I ++G+V GKF+ L+ PG+++ F VK V++ E V Sbjct: 70 IIIFISFFIWGVSGFYTITEAERGVVTSFGKFSHLVQPGLNWRPVFFNEVKPVNV-ETVR 128 Query: 71 DVPPQEV-ICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMEL 129 ++ + + D VV V+ V Y+I +P +++V ++ + + LR +IG + Sbjct: 129 ELATSGIMLTADENVVRVEMNVQYKITNPADYLFSVCYPDDSLRQATDSALRGVIGHSTM 188 Query: 130 DETLS-GRDIINAKLREELDKITD--RWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREK 186 D L+ GR ++ + ++E++ + G+ I V Q PP++++ A + A + Sbjct: 189 DRVLTEGRTLVRSDTQKEIENTIKPYKMGITILDVNFQTARPPEEVKAAFDDAIAARENR 248 Query: 187 RAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEK 246 + AE +A G+ Q + +A+ R IL A+G+ K+L ++A + Sbjct: 249 EQYVREAEAYSNEVKPKANGKAQRILEEAKSYSSRIILQAQGEVARFSKILPEYRIAKKI 308 Query: 247 YLTLQYIEKLPDLAK 261 L YIE + L + Sbjct: 309 TLKRLYIESMERLLR 323 >emb|CAB52016.1| (AL109665) SLP-1 [Homo sapiens] Length = 390 Score = 84.3 bits (205), Expect = 2e-15 Identities = 51/167 (30%), Positives = 90/167 (53%), Gaps = 8/167 (4%) Query: 13 LGIFLLIMLL-----LSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 LG LL++ ++K++ Y++ +V RLG+ PG+ ++PF++ + VDLR Sbjct: 55 LGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRT 114 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 +VPP ++ KD V++V A V ++I DPV +V V D A AQ + + + Sbjct: 115 RAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKR 174 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEI---QRIDPPKD 171 L E + I+ +L E++ +T WG+++ RVE+ + PP+D Sbjct: 175 PLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQD 221 >gb|AAF06960.1| (AF156557) stomatin related protein [Homo sapiens] >gi|6671068|gb|AAF23080.1| (AF156564) stomatin related protein [Homo sapiens] Length = 398 Score = 84.3 bits (205), Expect = 2e-15 Identities = 51/167 (30%), Positives = 90/167 (53%), Gaps = 8/167 (4%) Query: 13 LGIFLLIMLL-----LSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 LG LL++ ++K++ Y++ +V RLG+ PG+ ++PF++ + VDLR Sbjct: 62 LGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRT 121 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 +VPP ++ KD V++V A V ++I DPV +V V D A AQ + + + Sbjct: 122 RAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKR 181 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEI---QRIDPPKD 171 L E + I+ +L E++ +T WG+++ RVE+ + PP+D Sbjct: 182 PLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQD 228 >pir||B82806 integral membrane proteinase XF0453 [imported] - Xylella fastidiosa (strain 9a5c) >gi|9105297|gb|AAF83263.1|AE003895_14 (AE003895) integral membrane proteinase [Xylella fastidiosa] Length = 287 Score = 84.3 bits (205), Expect = 2e-15 Identities = 72/233 (30%), Positives = 116/233 (48%), Gaps = 10/233 (4%) Query: 11 IILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRL-LDPGIHFIIPFMERVKVVDLREHV 69 I++ L + L S+ V+R Q +V LG+ R L G+HF IP +E V++ D R V Sbjct: 7 IVVTAVLFLSLFSSIFVVREDQTAMVINLGRVVRYDLKSGLHFKIPLVESVRLFDRRFKV 66 Query: 70 IDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVS--DFLMAIVKLAQT---NLRAII 124 + P + V+VD I D V++ Y + D A +LA +LR I Sbjct: 67 MATEPARYFTAEQKDVSVDFFAIGYIED-VRSFYRATGGDESQAAARLAPIITDSLRNQI 125 Query: 125 GEMELDETLSG-RDIINAKLREELDKITDRWGVKITRVEIQRIDPPKDIQ--EAMAKQMT 181 L E +SG R + A + ++ T GV I + I++I+ P D Q + ++M Sbjct: 126 NSRTLQELVSGDRSELIAGQLKSINAATKGLGVHIVDLRIKQIELPVDSQVISDVYERMR 185 Query: 182 AEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIR 234 A+R++ A L AEG++ + A+ +++ +L A+ E+ Q L EG AEA R Sbjct: 186 AQRKQEAAKLRAEGEERSLSIRAQADRESTVLIADAERDAQKLRGEGDAEAAR 238 >gi|11432457 stomatin-like protein 1 [Homo sapiens] Length = 267 Score = 84.3 bits (205), Expect = 2e-15 Identities = 51/167 (30%), Positives = 90/167 (53%), Gaps = 8/167 (4%) Query: 13 LGIFLLIMLL-----LSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 LG LL++ ++K++ Y++ +V RLG+ PG+ ++PF++ + VDLR Sbjct: 62 LGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRT 121 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 +VPP ++ KD V++V A V ++I DPV +V V D A AQ + + + Sbjct: 122 RAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKR 181 Query: 128 ELDETLSGRDIINAKLREELDKITDRWGVKITRVEI---QRIDPPKD 171 L E + I+ +L E++ +T WG+++ RVE+ + PP+D Sbjct: 182 PLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQD 228 >emb|CAB64583.1| (AL135941) hypothetical protein L391.06 [Leishmania major] Length = 277 Score = 83.9 bits (204), Expect = 2e-15 Identities = 71/236 (30%), Positives = 115/236 (48%), Gaps = 12/236 (5%) Query: 34 GLVERLGKFNRLLDPGIHFIIPFMERVKVVDLR--EHVIDVPPQEVICKDNVVVTVDAVV 91 G+VE G+F+ DPGIH + V+ V LR E+ + V E KDNV VT+ V+ Sbjct: 13 GIVETCGRFSYTADPGIHCLWCGSVLVRRVTLRLQEYELKV---ESKTKDNVFVTLSLVI 69 Query: 92 YYQIL-DPVKAVYNVSDFLMAIVK-LAQTNLRAIIGEMELDETLSGRDIINAKLREELDK 149 YQ+ D + VY D + ++ ++RA I +L+ R I+ +L++E+D Sbjct: 70 QYQVSPDKLAEVYYACDSSLQCMRDYVLNSIRAKIPLYKLEALYVERGTISQQLKDEVDA 129 Query: 150 ITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQ 209 I +G++I I IDP +I +AM + +R + A + AE +K +R AE + + Sbjct: 130 IIGTYGIEIVSALISDIDPGAEITKAMNEVQKFQRLRVASVDAAETEKLKRVRAAEARCE 189 Query: 210 AAILKAEGEKQRQILIAEGQAEAIRKVLEALK-----MADEKYLTLQYIEKLPDLA 260 A L EG +++ I G +I V ++ A L QY + L +A Sbjct: 190 ARRLSGEGLAEQRKAIVAGLMHSIEDVQSEVRDLTSNDATNMLLMNQYYDTLQAIA 245 >sp|P57630|HFLC_BUCAI HFLC PROTEIN >gi|10039223|dbj|BAB13257.1| (AP001119) hflC protein [Buchnera sp. APS] Length = 310 Score = 83.5 bits (203), Expect = 3e-15 Identities = 71/291 (24%), Positives = 140/291 (47%), Gaps = 27/291 (9%) Query: 10 LIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNR-------LLDPGIHFIIPFMERVKV 62 LI L ++L S +++ ++G+V + GK R + +PG+HF PF+E VK+ Sbjct: 5 LIFASSVLFLILSSSFFIVKEGERGIVLQFGKVLRNNELKTVVYNPGLHFKWPFLETVKM 64 Query: 63 VDLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVK--AVYNVSDFLMAIVKLAQ--- 117 +D R H +D + K+ + VD+ + ++I D + D A V L + Sbjct: 65 LDARIHTMDNQADRFVTKEKKDLIVDSYIKWRINDFSRYYLATGGGDVFQAEVLLKRKFS 124 Query: 118 TNLRAIIGEMELDETLS---GR---DIINA--KLREELDKIT-------DRWGVKITRVE 162 LR+ IG + + E ++ GR D++N+ K L+K + + G+ + V Sbjct: 125 DRLRSEIGRLNVKEIVTDSRGRLTTDVLNSLNKGSMNLEKSSLINVNSMNALGIHVVDVR 184 Query: 163 IQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQ 222 I++I+ P ++ +A+ +M AERE A ++G+++A A + +I+ +E K+ Sbjct: 185 IKQINLPVEVSDAIYNRMRAEREAVARSQRSQGQEKAEKLRASADYKVSIILSEARKEAL 244 Query: 223 ILIAEGQAEAIRKVLEALKMADEKYLTLQYIEKLPDLAKYGNLIVPYDTES 273 I+ +G+AE + + + Y ++ + + K I+ D++S Sbjct: 245 IIKGQGEAEVTKLFAKNFNKEPDFYFFIRSLRAYENSFKNNRNIMLIDSDS 295 >sp|O83151|HFLK_TREPA HFLK PROTEIN >gi|7521161|pir||H71364 probable Lambda CII stability-governing protein (hflK) - syphilis spirochete >gi|3322375|gb|AAC65102.1| (AE001196) Lambda CII stability-governing protein (hflK) [Treponema pallidum] Length = 328 Score = 83.1 bits (202), Expect = 4e-15 Identities = 74/302 (24%), Positives = 142/302 (46%), Gaps = 27/302 (8%) Query: 12 ILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDL------ 65 +LGI +++ + +++I P G+V R GK++R L+PG+H++IPF+E V V + Sbjct: 21 VLGI-VIVGIASPIRIISPTDNGVVTRFGKYHRTLEPGLHYLIPFVEWVYKVPVTKVQKE 79 Query: 66 -----------REHVIDVPPQE--VICKDNVVVTVDAVVYYQILDPVKAVYNV--SDFLM 110 + H ++ E ++ D +V V+ VV Y+I+DP V+NV + Sbjct: 80 EFGFRTSKSSEQSHYVNNISHESLMLTGDLNIVDVEWVVQYRIVDPRAWVFNVESQERRQ 139 Query: 111 AIVKLAQTNLRAIIGEME-LDETLSGRDIINAKLREELDKITDR--WGVKITRVEIQRID 167 I +++ + ++IG+ LD R I + ++ ++ + R GV ++ V++Q + Sbjct: 140 TIRDISKAVVNSLIGDRAILDIMGPERSAIQMRAKDMMNVLLKRIGLGVLVSSVQLQNVV 199 Query: 168 PPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAE 227 PP+++Q+A A ++ +I + I +A G I +A G ++ A+ Sbjct: 200 PPQEVQQAFEDVNIAIQDMNRLINEGKESYNREIPKARGDADKLIQEAMGYANERVNRAK 259 Query: 228 GQAEAIRKVLEALKMADEKYLTLQYIEKL-PDLAKYGN-LIVPYDTESLIGLLRVLQKVK 285 G + A T Y+E L L K N L++ E+L+ L + + K Sbjct: 260 GDVARFDSIYAEYVKAPHVTKTRLYLEGLGAILEKTENVLLIDKKLENLLTLKDISKVSK 319 Query: 286 SI 287 + Sbjct: 320 KV 321 >gb|AAF03497.1|AC010676_7 (AC010676) unknown protein [Arabidopsis thaliana] >gi|6714460|gb|AAF26146.1|AC008261_3 (AC008261) unknown protein [Arabidopsis thaliana] Length = 285 Score = 80.4 bits (195), Expect = 2e-14 Identities = 61/202 (30%), Positives = 104/202 (51%), Gaps = 7/202 (3%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 ER GKF ++L+PG+ F+ P++ V + LR +DV E KDNV VTV A + Y Sbjct: 19 ERFGKFQKVLNPGLQFV-PWVIGDYVAGTLTLRLQQLDVQC-ETKTKDNVFVTVVASIQY 76 Query: 94 QIL--DPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 ++L A Y +S+ I +RA + ++ LD+ ++ I + EELDK Sbjct: 77 RVLADKASDAFYRLSNPTTQIKAYVFDVIRACVPKLNLDDVFEQKNEIAKSVEEELDKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I I+P + ++ AM + A R + A AE +K I+ AEG+ ++ Sbjct: 137 TAYGYEILQTLIIDIEPDQQVKRAMNEINAAARMRVAASEKAEAEKIIQIKRAEGEAESK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAI 233 L G +++ I +G +++ Sbjct: 197 YLSGLGIARQRQAIVDGLRDSV 218 >gb|AAF07389.1|AC010675_12 (AC010675) unknown protein; 58197-59415 [Arabidopsis thaliana] Length = 286 Score = 80.0 bits (194), Expect = 3e-14 Identities = 67/246 (27%), Positives = 117/246 (47%), Gaps = 15/246 (6%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 E GKF+ +L+PG H +P+ +V + LR +DV E KDNV VTV A + Y Sbjct: 19 ETFGKFDEVLEPGCH-CLPWCLGSQVAGHLSLRVQQLDVRC-ETKTKDNVFVTVVASIQY 76 Query: 94 QIL--DPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 + L A Y +S+ I +RA + +++LD T ++ I + EL+K Sbjct: 77 RALAESAQDAFYKLSNTRNQIQAYVFDVIRASVPKLDLDSTFEQKNDIAKTVETELEKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I I+P ++ AM + A R + A AE +K I+ AEG+ ++ Sbjct: 137 SHYGYEIVQTLIVDIEPDVHVKRAMNEINAASRMREAASEKAEAEKILQIKRAEGEAESK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEK-----YLTLQYIEKLPDL---AKYG 263 L G +++ I +G ++ E++ K L QY + L ++ +K Sbjct: 197 YLSGMGIARQRQAIVDGLRNSVLAFSESVPGTSSKDVMDMVLVTQYFDTLKEIGASSKSN 256 Query: 264 NLIVPY 269 ++ +P+ Sbjct: 257 SVFIPH 262 >dbj|BAB06874.1| (AP001517) protease specific for phage lambda cII repressor [Bacillus halodurans] Length = 319 Score = 79.6 bits (193), Expect = 4e-14 Identities = 75/313 (23%), Positives = 146/313 (45%), Gaps = 31/313 (9%) Query: 8 VALIILGIFLLIMLLLSVKVIRPYQKGLVERLGKFNRLLD-PGIHFIIPF-MERVKVV-- 63 + ILG+FL+ ++ ++ + GK +D PG+ F +P+ +++V+++ Sbjct: 14 IGAAILGLFLVT----GWYIVDETEQAALITFGKVEETIDEPGLKFKMPWPIQKVEILPR 69 Query: 64 -----------DLREHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAI 112 D E V ++I D +V D V ++I DP + +Y+ D + Sbjct: 70 GTFNLQVGYKEDEGEVVEFTDEAKMITGDENIVFADLAVQWRITDPEQYLYSTEDPKELL 129 Query: 113 VKLAQTNLRAIIGEMELDETLSG-RDIINAKLREELDKITDRW--GVKITRVEIQRID-P 168 + LR++IG +DE L+ R I A + E L ++ D + G+ I+ V++Q ++ P Sbjct: 130 YNATSSALRSVIGSASVDEALTDERPTIEADIFESLVELMDLYQIGISISDVKLQDVELP 189 Query: 169 PKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEG 228 ++++ A A E+ I A + E EG+K A I +AEG++ +I A G Sbjct: 190 TEEVRRAFTDVTDAREERLTKINEANRYRNQETNEVEGEKDAIISRAEGQRADRIETARG 249 Query: 229 QAEAIRKVLEALKM---ADEKYLTLQYIEK-LPDLAKYGNLIVPYDTESLIGL-LRVLQK 283 + E + + L L+ +E LPD Y I+ + +++ L +R L++ Sbjct: 250 DVARFNALYEEYLVNPDVTRQRLVLETLESILPDTEIY---IMDSNNDTINYLPIRPLER 306 Query: 284 VKSIPLQQSTEKK 296 + P+++ T + Sbjct: 307 QQQAPVEEGTNNE 319 >gb|AAF68390.1|AF236374_1 (AF236374) hypersensitive-induced response protein [Zea mays] Length = 284 Score = 78.8 bits (191), Expect = 7e-14 Identities = 67/246 (27%), Positives = 119/246 (48%), Gaps = 15/246 (6%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 E GKF+ +L+PG HF+ P+ ++ + LR +DV E KDNV VTV A V Y Sbjct: 19 ENFGKFSEVLEPGCHFL-PWCIGQQIAGYLSLRVRQLDVRC-ETKTKDNVFVTVVASVQY 76 Query: 94 QIL--DPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 + L A Y +S+ I +RA + ++ LD+ ++ I + EEL+K Sbjct: 77 RALADKASDAFYKLSNTREQIQSYVFDVIRATVPKLGLDDAFEQKNEIAKAVEEELEKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I I+P ++ AM + A R + A AE +K I++AEG+ ++ Sbjct: 137 STYGYQIVQTLIVDIEPDDRVKRAMNEINAAARMRVAASEKAEAEKILQIKKAEGEAESK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAIRKVLE-----ALKMADEKYLTLQYIEKLPDL---AKYG 263 L G +++ I +G +++ E K + L QY + + ++ +K Sbjct: 197 YLAGVGIARQRQAIVDGLRDSVLAFSENVPGTTAKDIMDMVLVTQYFDTMREIGASSKSS 256 Query: 264 NLIVPY 269 ++ +P+ Sbjct: 257 SVFIPH 262 >gb|AAF68391.1|AF236375_1 (AF236375) hypersensitive-induced response protein [Zea mays] Length = 287 Score = 77.6 bits (188), Expect = 2e-13 Identities = 60/202 (29%), Positives = 101/202 (49%), Gaps = 7/202 (3%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 E+ GKF+ +L+PG H +P+ +V + LR +DV E KDNV V V A + Y Sbjct: 19 EQFGKFDSVLEPGCH-CMPWFAGKRVAGQLTLRLQQLDVRC-ETKTKDNVFVNVVASIQY 76 Query: 94 QIL--DPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 + L A Y +S+ I +RA + ++ LD+ +D I + EEL+K Sbjct: 77 RALADKASDAFYKLSNTRSQIQAYVFDVIRASVPKLHLDDAFEQKDEIARAVEEELEKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I I+P + ++ AM + A R + A AE +K I+ AEG+ +A Sbjct: 137 SAYGFEIVQTLIVDIEPDEHVKRAMNEINAAARLRAAANEKAEAEKIVQIKRAEGEAEAK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAI 233 L G +++ I +G +++ Sbjct: 197 YLSGLGIARQRQAIVDGLRDSV 218 >gb|AAF68389.1|AF236373_1 (AF236373) hypersensitive-induced response protein [Zea mays] Length = 284 Score = 76.9 bits (186), Expect = 3e-13 Identities = 66/246 (26%), Positives = 117/246 (46%), Gaps = 15/246 (6%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 E GKF+ +L+PG HF+ P+ ++ + LR +DV E KDNV V V A V Y Sbjct: 19 ETFGKFDEVLEPGCHFL-PWCIGKQIAGYLSLRVQQLDVRC-ETKTKDNVFVNVVASVQY 76 Query: 94 QIL--DPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 + L A Y +S+ I +RA + +M LD+ ++ I + EL+K Sbjct: 77 RALADKASDAFYRLSNTREQIQSYVFDVIRASVPKMNLDDAFEQKNEIAKAVENELEKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I I+P + ++ AM + A R + A AE +K I+ AEG ++ Sbjct: 137 SMYGYEIVQTLIVDIEPDEHVKRAMNEINAAARLRLAASEKAEAEKILQIKRAEGDAESK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAIRKVLE-----ALKMADEKYLTLQYIEKLPDL---AKYG 263 L G +++ I +G +++ E + K + L QY + + ++ +K Sbjct: 197 YLAGLGIARQRQAIVDGLRDSVLAFSENVPGTSAKDVMDMVLVTQYFDTMKEIGASSKSS 256 Query: 264 NLIVPY 269 ++ +P+ Sbjct: 257 SVFIPH 262 >pir||I39620 hypothetical protein X - Anabaena variabilis (fragment) >gi|600250|dbj|BAA04562.1| (D17710) orfX [Anabaena variabilis] Length = 293 Score = 76.5 bits (185), Expect = 4e-13 Identities = 53/211 (25%), Positives = 105/211 (49%), Gaps = 3/211 (1%) Query: 28 IRPYQKGLVERLGKFNRLLDPGIH--FIIPFMERVKVVDLREHVIDVPPQEVICKDNVVV 85 + P GL+ +F L G H ++ + +V DLR+ ++V Q+++ KD V + Sbjct: 65 VPPQHIGLLYINQEFQAQLPSGKHAWWLFGRSWQTEVFDLRQQTLEVSGQDILSKDKVPL 124 Query: 86 TVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLRE 145 ++ Y++LDP++A +SD L + K Q LR +GE LD L + I+ + E Sbjct: 125 RLNLTAGYRLLDPLRARNGLSDILNYLYKELQFALRGAVGERSLDALLEDKGTIDRSIFE 184 Query: 146 ELDKITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAE 205 + + T +G+++ V ++ I P +I+ ++K + AE+ +A + + ++ AA R Sbjct: 185 YIRQKTADYGIEVDSVGVKDIILPGEIKTILSKVVEAEKAAQANV-VRRREETAATRSML 243 Query: 206 GQKQAAILKAEGEKQRQILIAEGQAEAIRKV 236 + + +++ + E AE I K+ Sbjct: 244 NTARVMEDNPVALRLKELEVLERIAEKIEKI 274 >pir||E83340 hypothetical protein PA2438 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9948485|gb|AAG05826.1|AE004671_2 (AE004671) hypothetical protein [Pseudomonas aeruginosa] Length = 341 Score = 75.7 bits (183), Expect = 6e-13 Identities = 72/269 (26%), Positives = 128/269 (46%), Gaps = 26/269 (9%) Query: 10 LIILGIFLLIMLLLSVKV-IRPYQKGLVERLGKFNR-LLDPGIHFIIPF-MERVKVVDLR 66 L++ + +L + + V +R + ++ R G R LL+PG+ + +P E VDLR Sbjct: 37 LLVAALLVLFAVAAACLVQVRSGEAMVITRFGNPARVLLEPGLAWRLPLPFESAIPVDLR 96 Query: 67 EHVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKL---AQTNLRAI 123 Q+V +D + + V A V +Q+ NV F+ A+ A LR Sbjct: 97 LRTTSSGLQDVGTRDGLRIIVQAYVAWQVQGDAD---NVQRFMRAVRNQPDEAARQLRTF 153 Query: 124 IGEMELDETLSGRDIIN---------------AKLREELD-KITDRWGVKITRVEIQRID 167 +G L+ T S D+ + A+LRE++D ++ +GVK+ +V I+R+ Sbjct: 154 VGSA-LETTASAYDLADLVNTEASRVRIGDFEARLREQIDHQLLATYGVKVVQVGIERLT 212 Query: 168 PPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAE 227 PK A +M AERE A AEG+++AA + ++ A +++AE + + A+ Sbjct: 213 LPKVTLGATVDRMRAERETIATERTAEGRRQAAEIRSAAERDARVIQAEASVKAAEIEAQ 272 Query: 228 GQAEAIRKVLEALKMADEKYLTLQYIEKL 256 + EA R +A + + Y L+ ++ L Sbjct: 273 ARVEAARIYGKAYAGSPQLYNLLRSLDTL 301 >emb|CAC07434.1| (AJ292360) putative membrane protein [Zea mays] Length = 284 Score = 75.3 bits (182), Expect = 8e-13 Identities = 64/233 (27%), Positives = 110/233 (46%), Gaps = 12/233 (5%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 E GKF+ +L+PG HF+ P+ ++ + LR +DV E KDNV V V A V Y Sbjct: 19 ETFGKFDEVLEPGCHFL-PWCIGKQIAGYLSLRVQQLDVRC-ETKTKDNVFVNVVASVQY 76 Query: 94 QIL--DPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 + L A Y +S+ I +RA + +M LD+ ++ I + EL+K Sbjct: 77 RALADKASDAFYRLSNTREQIQSYVFDVIRASVPKMNLDDAFEQKNEIAKAVENELEKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I I+P + ++ AM + A R + A AE +K I+ AEG ++ Sbjct: 137 SMYGYEIVQTLIVDIEPDEHVKRAMNEINAAARLRLAASEKAEAEKILQIKRAEGDAESK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAIRKVLE-----ALKMADEKYLTLQYIEKLPDL 259 L G +++ I +G +++ E + K + L QY + + ++ Sbjct: 197 YLAGLGIARQRQAIVDGLRDSVLAFSENVPGTSAKDVMDMVLVTQYFDTMEEI 249 >dbj|BAB08673.1| (AB018109) gb|AAF03497.1~gene_id:K17N15.12~similar to unknown protein [Arabidopsis thaliana] Length = 292 Score = 73.4 bits (177), Expect = 3e-12 Identities = 59/235 (25%), Positives = 106/235 (45%), Gaps = 10/235 (4%) Query: 34 GLVERLGKFNRLLDPGIHFIIPFMER--VKVVDLREHVIDVPPQEVICKDNVVVTVDAVV 91 G+VER G+F + +PG HF P + V+ R +DV E KDNV V + + Sbjct: 18 GVVERWGRFEHIAEPGCHFFNPLAGQWLAGVLSTRIKSLDVKI-ETKTKDNVFVQLVCSI 76 Query: 92 YYQILDPVK--AVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDK 149 Y+++ A Y + + I +RA++ M LD + + + EEL+K Sbjct: 77 QYRVVKASADDAFYELQNPKEQIQAYVFDVVRALVPMMTLDALFEQKGEVAKSVLEELEK 136 Query: 150 ITDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQ 209 + +G I + + I P +++AM + A+R + A + E +K ++ AE + + Sbjct: 137 VMGAYGYSIEHILMVDIIPDPSVRKAMNEINAAQRLQLASVYKGEAEKILQVKRAEAEAE 196 Query: 210 AAILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEK-----YLTLQYIEKLPDL 259 A L G +++ I +G E I + ++ K + QY + + DL Sbjct: 197 AKYLGGVGVARQRQAITDGLRENILNFSDKVEGTSAKEVMDLIMITQYFDTIRDL 251 >pir||C81445 probable transmembrane protein Cj0268c [imported] - Campylobacter jejuni (strain NCTC 11168) >gi|6967745|emb|CAB72736.1| (AL139074) putative transmembrane protein [Campylobacter jejuni] Length = 362 Score = 73.0 bits (176), Expect = 4e-12 Identities = 62/283 (21%), Positives = 138/283 (47%), Gaps = 38/283 (13%) Query: 6 GGVALIILGIFLLIMLLLSVK---VIRPYQKGLVERLGKFN-RLLDPGIHFIIPFMERVK 61 G + + G+ ++I+ L+ K VI + G+ GK++ L+PG+HF +PF++++ Sbjct: 40 GKFSPFVYGVIIIILFLIVAKPFMVINSGEMGIKSTTGKYDPNPLEPGLHFFLPFVQKIT 99 Query: 62 VVDLREHVIDVPPQE-----------VICKDNV--------VVTVDAVVYYQILDPVKAV 102 ++D R I+ E VI K+++ V++D V Y+ L+P++ Sbjct: 100 IIDTRVRQINYASIEGSNENLSSGSGVINKNSISVLDSRGLPVSIDVTVQYR-LNPLQVP 158 Query: 103 YNVSDFLM-----AIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKITD---RW 154 ++ + + I + + +R+++G+ +E + R+ I ++ E + K + Sbjct: 159 QTIATWSLNWENKIIDPVVRDVVRSVVGKYTAEELPTNRNTIATQIEEGIRKTIEAQPNE 218 Query: 155 GVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIRE---AEGQKQAA 211 V++ V+++ I P ++E + + A++E E + A+++ AEG+ A Sbjct: 219 PVELRAVQLREIILPSKVKEQIERVQIAKQEAERTKYEVERANQEALKKAALAEGEANAT 278 Query: 212 ILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEKYLTLQYIE 254 I+ A+G+ + A+ QA + +++ +L + L L+ IE Sbjct: 279 IISAKGKAMAVKIEADAQAYSNKEIANSL---NTPLLNLKQIE 318 >dbj|BAB10843.1| (AB009053) hypersensitive-induced response protein [Arabidopsis thaliana] Length = 286 Score = 72.6 bits (175), Expect = 5e-12 Identities = 59/202 (29%), Positives = 100/202 (49%), Gaps = 7/202 (3%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 E GKF +L+PG HF+ P+ +V + LR +DV E KDNV V V A + Y Sbjct: 19 ETFGKFEDVLEPGCHFL-PWCLGSQVAGYLSLRVQQLDVRC-ETKTKDNVFVNVVASIQY 76 Query: 94 QIL--DPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 + L A Y +S+ I +RA + ++ LD+ ++ I + EEL+K Sbjct: 77 RALANKANDAYYKLSNTRGQIQAYVFDVIRASVPKLLLDDVFEQKNDIAKAVEEELEKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I I+P + ++ AM + A R + A AE +K I+ AEG+ ++ Sbjct: 137 SAYGYEIVQTLIVDIEPDEHVKRAMNEINAAARMRLAANEKAEAEKILQIKRAEGEAESK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAI 233 L G +++ I +G +++ Sbjct: 197 YLSGLGIARQRQAIVDGLRDSV 218 >emb|CAB64584.1| (AL135941) hypothetical protein L391.07 [Leishmania major] Length = 283 Score = 72.2 bits (174), Expect = 7e-12 Identities = 56/218 (25%), Positives = 102/218 (46%), Gaps = 15/218 (6%) Query: 34 GLVERLGKFNRLLDPGIHFIIPFMERVKVVDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 G++E GKF+R DPG I+P +E V+ V + I E +DN VV ++ ++Y Sbjct: 15 GIIENCGKFDRTADPGCFCIVPCVESVRGVVSLKVAISTVRVETKTRDNAVVNIETRLHY 74 Query: 94 QILDPVK--AVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 +++ A Y S+ I A + +R + + LDE D I + EL + Sbjct: 75 KVIAECAEDAFYRFSNPSEQIASFAASVVRGEVPKYTLDELFLMSDEIKKVVSAELTEKL 134 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAK-QMTAEREKRAMILIAEGKKEAAIREAEGQKQA 210 +G + + RI+P ++ A+++ Q+ A R + AA E+E K Sbjct: 135 RGFGFSLESTLLTRIEPSASVKTAISQTQINAYR------------RTAAEHESELNKIL 182 Query: 211 AILKAEGEKQRQILIAEGQAEAIRKVLEALKMADEKYL 248 A+ AE + + + L G A+ + +++ LK + E ++ Sbjct: 183 AVKAAEADYEEKRLSGVGLAQERQAIMKGLKSSIESFV 220 >sp|P44545|HFLC_HAEIN HFLC PROTEIN >gi|1074959|pir||I64050 probable integral membrane proteinase hflC homolog - Haemophilus influenzae (strain Rd KW20) >gi|1573107|gb|AAC21821.1| (U32701) hflC protein (hflC) [Haemophilus influenzae Rd] Length = 295 Score = 71.0 bits (171), Expect = 2e-11 Identities = 56/235 (23%), Positives = 112/235 (46%), Gaps = 22/235 (9%) Query: 24 SVKVIRPYQKGLVERLGKFNR-------LLDPGIHFIIPFMERVKVVDLREHVIDVPPQE 76 S+ V+ +G++ R K R + +PG+HF +P ++ +KV+D R +D Sbjct: 19 SIVVVTEGTRGIMLRFNKVQRDADNKVVVYEPGLHFKVPLIDSIKVLDARIRTLDGSATR 78 Query: 77 VICKDNVVVTVDAVVYYQILDPVKAVYNVS--DFLMAIVKLAQT---NLRAIIGEMELDE 131 + + + VD+ V ++I D + + D+ A L++ LR+ IG + + Sbjct: 79 FVTVEKKDLLVDSYVKWKISDFGRFYTSTGGGDYAQAANLLSRKVNDRLRSEIGSRTIKD 138 Query: 132 TLSGRDIINAKLREELDKI-------TDRWGVKITRVEIQRIDPPKDIQEAMAKQMTAER 184 +SG +L E K T G+++ V +++I+ P ++ ++ ++M AER Sbjct: 139 IVSGT---RGELMEGAKKALSSGQDSTAELGIEVIDVRVKQINLPDEVSSSIYQRMRAER 195 Query: 185 EKRAMILIAEGKKEAAIREAEGQKQAAILKAEGEKQRQILIAEGQAEAIRKVLEA 239 + A ++GK++AA +A+ ++ ++ A K Q L G A A + +A Sbjct: 196 DAVAREHRSQGKEKAAFIQADVDRKVTLILANANKTAQELRGSGDAAAAKLYSDA 250 >emb|CAA10289.1| (AJ131049) hypothetical protein [Cicer arietinum] Length = 286 Score = 70.6 bits (170), Expect = 2e-11 Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 15/246 (6%) Query: 37 ERLGKFNRLLDPGIHFIIPFMERVKV---VDLREHVIDVPPQEVICKDNVVVTVDAVVYY 93 E+ G+F +L+PG H +P+ ++ + LR +DV E KDNV V V A V Y Sbjct: 19 EQFGRFVDVLEPGCH-CLPWCLGYQIAGGLSLRVQQLDVKC-ETKTKDNVFVMVVASVQY 76 Query: 94 Q-ILDPVK-AVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINAKLREELDKIT 151 + + D A Y +++ I +RA + ++ELD ++ I + +EL+K Sbjct: 77 RAVADKASDAFYRLTNTREQIQSYVFDVIRASVPKLELDAVFEQKNDIAKAVEDELEKAM 136 Query: 152 DRWGVKITRVEIQRIDPPKDIQEAMAKQMTAEREKRAMILIAEGKKEAAIREAEGQKQAA 211 +G +I + I ++P +++ AM + A R + A AE +K I++AEG+ ++ Sbjct: 137 SNYGYEIVQTLIVDVEPDVNVKRAMNEINAAARLRLAANDKAEAEKILQIKKAEGEAESK 196 Query: 212 ILKAEGEKQRQILIAEGQAEAIRKVLE-----ALKMADEKYLTLQYIEKLPDL---AKYG 263 L G +++ I +G +++ E + K + L QY + + ++ +K Sbjct: 197 YLSGLGIARQRQAIVDGLRDSVLAFSENVPGTSAKDVMDMVLVTQYFDTMKEIGASSKSS 256 Query: 264 NLIVPY 269 ++ +P+ Sbjct: 257 SVFIPH 262 >gb|AAD42031.1|AF074953_1 (AF074953) stomatin-like protein UNC24 [Homo sapiens] Length = 393 Score = 69.1 bits (166), Expect = 6e-11 Identities = 51/169 (30%), Positives = 88/169 (51%), Gaps = 11/169 (6%) Query: 13 LGIFLLIMLL-----LSVKVIRPYQKGLVERLGKFNRLLDPGIHFIIPFMERVKVVDLRE 67 LG LL++ ++K++ Y++ +V RLG+ PG+ ++PF++ + VDLR Sbjct: 57 LGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRT 116 Query: 68 HVIDVPPQEVICKDNVVVTVDAVVYYQILDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEM 127 +VPP ++ KD V++V A V ++I DPV +V V D A AQ + + + Sbjct: 117 RAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKR 176 Query: 128 ELDETLSGRDIINAKLREELDKITDR--WGVKITRVEI---QRIDPPKD 171 L E + I+ +L E D+ D+ G ++ RVE+ + PP+D Sbjct: 177 PLREIQMEKLKISDQLLLE-DQRCDQGLGGWEVDRVELAVEAVLQPPQD 224 Database: ./suso.pep Posted date: Jul 6, 2001 5:57 PM Number of letters in database: 840,471 Number of sequences in database: 2977 Database: /banques/blast2/nr.pep Posted date: Dec 14, 2000 12:46 PM Number of letters in database: 188,266,275 Number of sequences in database: 595,510 Lambda K H 0.321 0.139 0.374 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 94872827 Number of Sequences: 2977 Number of extensions: 3672658 Number of successful extensions: 16160 Number of sequences better than 1.0e-10: 112 Number of HSP's better than 0.0 without gapping: 78 Number of HSP's successfully gapped in prelim test: 34 Number of HSP's that attempted gapping in prelim test: 15761 Number of HSP's gapped (non-prelim): 133 length of query: 299 length of database: 189,106,746 effective HSP length: 59 effective length of query: 240 effective length of database: 153,796,013 effective search space: 36911043120 effective search space used: 36911043120 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.8 bits) S2: 165 (68.7 bits)