BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1372 (ahcY) DE:adenosylhomocysteinase (ahcY)
(422 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75064 adenosylhomocysteinase (ahcy) PAB1372 - Pyrococcus a... 846 0.0
sp|O58275|SAHH_PYRHO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 795 0.0
pir||H71167 probable S-adenosyl-L-homocysteine hydrolase - Pyroc... 795 0.0
sp|O67240|SAHH_AQUAE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 545 e-154
sp|Q58783|SAHH_METJA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 534 e-151
gb|AAK41050.1| S-adenosyl-L-homocysteine hydrolase (ahcY) [Sulfo... 515 e-145
emb|CAB57547.1| (Y18930) s-adenosylhomocysteine hydrolase [Sulfo... 515 e-145
sp|P50252|SAHH_SULSO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 515 e-145
sp|O27673|SAHH_METTH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 506 e-142
gi|11499582 S-adenosylhomocysteinase hydrolase (ahcY-2) [Archaeo... 506 e-142
sp|O51933|SAHH_THEMA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 496 e-139
gb|AAC01562.1| (AF013268) S adenosylhomocysteine hydrolase [Ther... 496 e-139
sp|P74008|SAHH_SYNY3 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 470 e-131
pir||B72649 probable adenosylhomocysteinase APE0624 - Aeropyrum ... 460 e-128
emb|CAC11611.1| (AL445064) probable adenosylhomocysteinase [Ther... 446 e-124
gb|AAG20371.1| (AE005110) adenosylhomocysteinase; AchY [Halobact... 387 e-106
gi|9951915 S-adenosylhomocysteine hydrolase; adenosylhomocystein... 347 1e-94
gi|7709980 S-adenosylhomocysteine hydrolase [Mus musculus] >gi|1... 346 4e-94
gi|8392878 S-adenosylhomocysteine hydrolase [Rattus norvegicus] ... 346 4e-94
pdb|1B3R|A Chain A, Rat Liver S-Adenosylhomocystein Hydrolase >g... 346 4e-94
sp|P23526|SAHH_HUMAN ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 345 5e-94
sp|P51893|SAH1_XENLA ADENOSYLHOMOCYSTEINASE 1 (S-ADENOSYL-L-HOMO... 345 5e-94
sp|O93477|SAH2_XENLA ADENOSYLHOMOCYSTEINASE 2 (S-ADENOSYL-L-HOMO... 345 5e-94
sp|O13639|SAHH_SCHPO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 339 4e-92
pdb|1A7A|A Chain A, Structure Of Human Placental S-Adenosylhomoc... 328 7e-89
gi|6320882 putative S-adenosyl-L-homocysteine hydrolase; Sah1p [... 324 1e-87
sp|O76757|SAHH_ANOGA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 324 1e-87
gb|AAF48453.1| (AE003499) Ahcy13 gene product [Drosophila melano... 316 3e-85
sp|Q27580|SAHH_DROME ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 313 2e-84
sp|P36889|SAHH_LEIDO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 312 5e-84
sp|P10819|SAHH_DICDI ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 312 5e-84
pir||A45569 adenosylhomocysteinase (EC 3.3.1.1) - Leishmania don... 311 1e-83
sp|O50562|SAHH_RHOSH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 306 3e-82
dbj|BAA34645.1| (AB020211) S-adenosyl L-homocystein hydrolase [R... 305 6e-82
sp|P27604|SAHH_CAEEL ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 305 6e-82
sp|P28183|SAHH_RHOCA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 303 2e-81
sp|P50251|SAHH_PYRFU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 298 8e-80
pir||A46035 adenosylhomocysteinase (EC 3.3.1.1) - Rhodobacter ca... 296 2e-79
emb|CAB88907.1| (AL353862) adenosylhomocysteinase [Streptomyces ... 292 4e-78
pir||D82730 adenosylhomocysteinase XF1037 [imported] - Xylella f... 289 3e-77
sp|O08364|SAHH_MYCTU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 289 3e-77
sp|Q12663|SAHH_PNECA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 284 1e-75
sp|P50250|SAHH_PLAF7 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 282 7e-75
gb|AAD56048.1|AF185635_1 (AF185635) S-adenosyl-L-homocysteinase ... 279 4e-74
sp|Q01781|SAHH_PETCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 277 1e-73
sp|P35007|SAHH_CATRO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 277 2e-73
sp|P51540|SAHH_TRIVA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 275 6e-73
sp|O23255|SAHH_ARATH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 274 1e-72
sp|P50248|SAHH_TOBAC ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 274 1e-72
sp|P32112|SAHH_WHEAT ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 273 3e-72
sp|P93253|SAHH_MESCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 272 6e-72
sp|P50246|SAHH_MEDSA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 271 1e-71
sp|P50249|SAHH_PHASS ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 270 2e-71
dbj|BAB01858.1| (AP000377) S-adenosyl L-homocystein hydrolase [A... 270 2e-71
dbj|BAA74851.1| (AB020635) KIAA0828 protein [Homo sapiens] 270 2e-71
gb|AAD50775.1|AF161705_1 (AF161705) S-adenosyl-l-homocysteine hy... 266 3e-70
sp|P50245|SAH2_DROME PUTATIVE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL... 266 4e-70
emb|CAB09795.1| (Z97059) S-adenosyl-L-homocysteine hydrolase [Ar... 265 1e-69
gi|5729724 S-adenosylhomocysteine hydrolase-like 1; S-adenosyl h... 265 1e-69
pir||T08681 adenosylhomocysteinase (EC 3.3.1.1) DKFZp564A1523 - ... 265 1e-69
pir||S01302 adenosylhomocysteinase (EC 3.3.1.1) - fruit fly (Dro... 264 2e-69
dbj|BAA03710.1| (D16139) cytokinin binding protein CBP57 [Nicoti... 263 3e-69
gb|AAF47685.1| (AE003476) CG9977 gene product [Drosophila melano... 258 7e-68
pir||H83591 S-adenosyl-L-homocysteine hydrolase PA0432 [imported... 253 2e-66
emb|CAC09529.1| (AL356299) bK3216D2.1.1 (S-adenosylhomocysteine ... 237 2e-61
gb|AAF19001.1|AF212157_1 (AF212157) S-adenosylhomocysteine hydro... 177 2e-43
gb|AAD20318.1| (AF105295) S-adenosyl-homocysteine hydrolase like... 155 6e-37
gb|AAD52668.2| (AF178115) S-adenosyl-L-homocysteine hydrolase [M... 155 8e-37
pir||T15035 adenosylhomocysteinase (EC 3.3.1.1) - parsley >gi|16... 138 9e-32
gb|AAB88189.1| (AF035319) similar to S-adenosylhomocysteine hydr... 131 2e-29
gi|11498491 S-adenosylhomocysteinase hydrolase (ahcY-1) [Archaeo... 109 8e-23
gb|AAD56027.1|AF181566_1 (AF181566) S-adenosyl-L-homocysteine hy... 100 4e-20
pir||S06394 adenosylhomocysteinase (EC 3.3.1.1) - slime mold (Di... 99 9e-20
gb|AAD29674.1|AF129871_1 (AF129871) S-adenosyl-L-homocysteine hy... 92 1e-17
gb|AAF70071.1|AF252255_1 (AF252255) S-adenosyl-L-homocysteinase ... 90 4e-17
gb|AAD52667.2| (AF178114) S-adenosyl-L-homocysteine hydrolase [M... 83 7e-15
sp|P26799|SAHH_STRFR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCY... 76 7e-13
>pir||B75064 adenosylhomocysteinase (ahcy) PAB1372 - Pyrococcus abyssi (strain
Orsay) >gi|5458920|emb|CAB50407.1| (AJ248287)
adenosylhomocysteinase (ahcY) [Pyrococcus abyssi]
Length = 422
Score = 846 bits (2161), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MVNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMK 60
MVNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMK
Sbjct: 1 MVNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMK 60
Query: 61 TAFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALD 120
TAFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALD
Sbjct: 61 TAFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALD 120
Query: 121 IRPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVND 180
IRPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVND
Sbjct: 121 IRPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVND 180
Query: 181 SYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVV 240
SYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVV
Sbjct: 181 SYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVV 240
Query: 241 EVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHF 300
EVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHF
Sbjct: 241 EVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHF 300
Query: 301 DVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSF 360
DVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSF
Sbjct: 301 DVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSF 360
Query: 361 ALQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQH 420
ALQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQH
Sbjct: 361 ALQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQH 420
Query: 421 GT 422
GT
Sbjct: 421 GT 422
>sp|O58275|SAHH_PYRHO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE)
Length = 421
Score = 795 bits (2032), Expect = 0.0
Identities = 392/421 (93%), Positives = 409/421 (97%)
Query: 2 VNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT 61
++C DYCVKD+SLA EG KKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT
Sbjct: 1 MDCGRDYCVKDLSLADEGWKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT 60
Query: 62 AFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI 121
AFLLLTLKAGGA+VSAAASNPLSTQDDVVAALAK GVKVYAIRGESKE+YYEFM+KALDI
Sbjct: 61 AFLLLTLKAGGAEVSAAASNPLSTQDDVVAALAKAGVKVYAIRGESKEQYYEFMHKALDI 120
Query: 122 RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDS 181
RPNIIIDDGADM+SLVH ER+ELLDEIWG SEETTTGVIRLRAMERD VLRF VIAVNDS
Sbjct: 121 RPNIIIDDGADMISLVHKERQELLDEIWGGSEETTTGVIRLRAMERDGVLRFSVIAVNDS 180
Query: 182 YMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 241
YMKYLFDNRYGTGQSTWDG+MRATNLL+AGKNVVVVGYGWCGRGIAMRARGLGATVIVVE
Sbjct: 181 YMKYLFDNRYGTGQSTWDGVMRATNLLIAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 240
Query: 242 VDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFD 301
VDPIKALEARMDGFLVM+MKEAAKIGDIF+TATG+IKCIRREHFELMKDGAIMANAGHFD
Sbjct: 241 VDPIKALEARMDGFLVMNMKEAAKIGDIFITATGDIKCIRREHFELMKDGAIMANAGHFD 300
Query: 302 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 361
VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA
Sbjct: 301 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 360
Query: 362 LQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHG 421
LQAKAAEYIK+NH +LEPRVY+LPREIDEMVARIKL SMGI IEELTEEQKKYLESW+HG
Sbjct: 361 LQAKAAEYIKDNHGKLEPRVYILPREIDEMVARIKLASMGIEIEELTEEQKKYLESWEHG 420
Query: 422 T 422
T
Sbjct: 421 T 421
>pir||H71167 probable S-adenosyl-L-homocysteine hydrolase - Pyrococcus
horikoshii >gi|3256946|dbj|BAA29629.1| (AP000002) 425aa
long hypothetical S-adenosyl-L-homocysteine hydrolase
[Pyrococcus horikoshii]
Length = 425
Score = 795 bits (2032), Expect = 0.0
Identities = 392/421 (93%), Positives = 409/421 (97%)
Query: 2 VNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT 61
++C DYCVKD+SLA EG KKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT
Sbjct: 5 MDCGRDYCVKDLSLADEGWKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT 64
Query: 62 AFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI 121
AFLLLTLKAGGA+VSAAASNPLSTQDDVVAALAK GVKVYAIRGESKE+YYEFM+KALDI
Sbjct: 65 AFLLLTLKAGGAEVSAAASNPLSTQDDVVAALAKAGVKVYAIRGESKEQYYEFMHKALDI 124
Query: 122 RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDS 181
RPNIIIDDGADM+SLVH ER+ELLDEIWG SEETTTGVIRLRAMERD VLRF VIAVNDS
Sbjct: 125 RPNIIIDDGADMISLVHKERQELLDEIWGGSEETTTGVIRLRAMERDGVLRFSVIAVNDS 184
Query: 182 YMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 241
YMKYLFDNRYGTGQSTWDG+MRATNLL+AGKNVVVVGYGWCGRGIAMRARGLGATVIVVE
Sbjct: 185 YMKYLFDNRYGTGQSTWDGVMRATNLLIAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 244
Query: 242 VDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFD 301
VDPIKALEARMDGFLVM+MKEAAKIGDIF+TATG+IKCIRREHFELMKDGAIMANAGHFD
Sbjct: 245 VDPIKALEARMDGFLVMNMKEAAKIGDIFITATGDIKCIRREHFELMKDGAIMANAGHFD 304
Query: 302 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 361
VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA
Sbjct: 305 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 364
Query: 362 LQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHG 421
LQAKAAEYIK+NH +LEPRVY+LPREIDEMVARIKL SMGI IEELTEEQKKYLESW+HG
Sbjct: 365 LQAKAAEYIKDNHGKLEPRVYILPREIDEMVARIKLASMGIEIEELTEEQKKYLESWEHG 424
Query: 422 T 422
T
Sbjct: 425 T 425
>sp|O67240|SAHH_AQUAE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435517|pir||E70401
S-adenosylhomocysteine hydrolase - Aquifex aeolicus
>gi|2983629|gb|AAC07197.1| (AE000727)
S-adenosylhomocysteine hydrolase [Aquifex aeolicus]
Length = 418
Score = 545 bits (1388), Expect = e-154
Identities = 268/417 (64%), Positives = 332/417 (79%), Gaps = 1/417 (0%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
++ VKD+SLA EG+K+I+W MPVL+ IR F ++KP KG +I+A LH+ +TA L+
Sbjct: 2 EFDVKDLSLAEEGLKRIEWAEMDMPVLRQIRERFSKEKPLKGKKISACLHVTTETANLMR 61
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKE-GVKVYAIRGESKEEYYEFMNKALDIRPNI 125
TLK GGA+V ASNPLSTQDDV AAL K + V+AIRGE +E YY+ + ++ P++
Sbjct: 62 TLKEGGAEVYLTASNPLSTQDDVAAALVKYFEIPVFAIRGEDRETYYKHLRAVIEKEPDV 121
Query: 126 IIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKY 185
+IDDGAD++S +H E L +++ G EETTTGVIRLRAM VL+FP+IAVND+Y K+
Sbjct: 122 VIDDGADLISTLHKEYPGLAEKVLGGMEETTTGVIRLRAMAEQGVLKFPIIAVNDAYTKH 181
Query: 186 LFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPI 245
+FDNRYGTGQST DGI+RATN L+AG VV GYGWCG+G+A RARG+GA VIV EVDPI
Sbjct: 182 MFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQRARGMGAIVIVTEVDPI 241
Query: 246 KALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIW 305
KALEARMDGFLVM M+EAAK+GD FVT TGNI IRREHFE+MKDGAI+AN+GHF+VEI
Sbjct: 242 KALEARMDGFLVMPMEEAAKLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEID 301
Query: 306 KPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAK 365
P LEE+AVE R VTEYKLKDGRR+YLLA+GRLVNL AA+GHPA +MDMSF+ QA
Sbjct: 302 IPALEEMAVEKREIRKEVTEYKLKDGRRIYLLAEGRLVNLAAAEGHPASVMDMSFSNQAL 361
Query: 366 AAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
+AEYI ++H+ LE +VY +PREIDE VAR+KL ++GI I+ELTEEQKKYL SW+ GT
Sbjct: 362 SAEYIVKHHKELEKKVYRVPREIDEAVARLKLNALGIKIDELTEEQKKYLSSWEMGT 418
>sp|Q58783|SAHH_METJA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|2144481|pir||C64473
adenosylhomocysteinase (EC 3.3.1.1) - Methanococcus
jannaschii >gi|1592034|gb|AAB99397.1| (U67578)
adenosylhomocysteinase (ahcY) [Methanococcus jannaschii]
Length = 415
Score = 534 bits (1362), Expect = e-151
Identities = 265/415 (63%), Positives = 324/415 (77%), Gaps = 1/415 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V+DI+L EG +KI W + MPVL IR F+E+KPFKG+ I LHLE KTA L T
Sbjct: 2 YEVRDINLWKEGERKIQWAKQHMPVLNLIRERFKEEKPFKGITIGMALHLEAKTAVLAET 61
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIII 127
L GGA+++ NPLSTQDDV AA AK+G+ VYA RGE+ EEYYE +NK LD +P+I+I
Sbjct: 62 LMEGGAEIAITGCNPLSTQDDVAAACAKKGMHVYAWRGETVEEYYENLNKVLDHKPDIVI 121
Query: 128 DDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLF 187
DDG D++ L+HT+R ELLD I G EETTTG+IRL+AME++ L+FPV+ VND+Y K+LF
Sbjct: 122 DDGCDLIFLLHTKRTELLDNIMGGCEETTTGIIRLKAMEKEGALKFPVMDVNDAYTKHLF 181
Query: 188 DNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKA 247
DNRYGTGQS DGI+RATNLL+AGK VVV GYGWCGRG+AMRA+GLGA V+V EV+PI+A
Sbjct: 182 DNRYGTGQSALDGILRATNLLIAGKTVVVAGYGWCGRGVAMRAKGLGAEVVVTEVNPIRA 241
Query: 248 LEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKP 307
LEARMDGF VM M++AA+IGDIF+T TG IR+EH M++GAI+ANAGHFD EI K
Sbjct: 242 LEARMDGFRVMKMEKAAEIGDIFITTTGCKDVIRKEHILKMRNGAILANAGHFDNEINKK 301
Query: 308 DLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAA 367
LEELA I R VTEY L +++YLL +GRLVNL ADGHP E+MDMSFA QA AA
Sbjct: 302 HLEELAKSIKEVRNCVTEYDL-GNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALAA 360
Query: 368 EYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
EYI +NHE+LEPRVY +P E D M+A +KL++MGI I+ELT+EQKKYLE W+ GT
Sbjct: 361 EYILKNHEKLEPRVYNIPYEQDLMIASLKLKAMGIEIDELTKEQKKYLEDWREGT 415
>gb|AAK41050.1| S-adenosyl-L-homocysteine hydrolase (ahcY) [Sulfolobus
solfataricus]
Length = 442
Score = 515 bits (1311), Expect = e-145
Identities = 256/416 (61%), Positives = 324/416 (77%), Gaps = 2/416 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y +KD+SLA EG K+I+W R MP L IR+ F+ +KP KG+ I+A LH+ +TA L+ T
Sbjct: 28 YKIKDLSLASEGKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKETAALVKT 87
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIR-PNII 126
LK GGA V+ A SNPLSTQDDV AAL +EG+ V+A +GE++ EYY + + I PNI+
Sbjct: 88 LKIGGANVALAGSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIV 147
Query: 127 IDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYL 186
+DDGAD+ + +H + LD I+G +EETTTGVIRL+AME+D VL++P++AVN++Y KYL
Sbjct: 148 MDDGADLHAYIHEKVSSKLD-IYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYL 206
Query: 187 FDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIK 246
FDNRYGTGQS DGI+RATN+L+AGK VV GYGW GRGIA R RG+GA VIV EVDPI+
Sbjct: 207 FDNRYGTGQSAIDGILRATNILIAGKIAVVAGYGWVGRGIANRLRGMGARVIVTEVDPIR 266
Query: 247 ALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWK 306
ALEA MDGF VM + EA+K+GDIFVTATGN K IR EH MKDGAI++NAGHF+VE+
Sbjct: 267 ALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHFNVEVDV 326
Query: 307 PDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKA 366
L+E AV++ N RP V EY L +G+R+YLLADGRLVNL AA+GHP+E+MDMSFA QA A
Sbjct: 327 KGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALA 386
Query: 367 AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
EY+ +N +LE +VY +P E+D VARIKL+SMGI I+ELTEEQK+YLE W+ GT
Sbjct: 387 VEYLVKNRGKLEKKVYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWKSGT 442
>emb|CAB57547.1| (Y18930) s-adenosylhomocysteine hydrolase [Sulfolobus solfataricus]
Length = 442
Score = 515 bits (1311), Expect = e-145
Identities = 256/416 (61%), Positives = 324/416 (77%), Gaps = 2/416 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y +KD+SLA EG K+I+W R MP L IR+ F+ +KP KG+ I+A LH+ +TA L+ T
Sbjct: 28 YKIKDLSLASEGKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKETAALVKT 87
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIR-PNII 126
LK GGA V+ A SNPLSTQDDV AAL +EG+ V+A +GE++ EYY + + I PNI+
Sbjct: 88 LKIGGANVALAGSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIV 147
Query: 127 IDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYL 186
+DDGAD+ + +H + LD I+G +EETTTGVIRL+AME+D VL++P++AVN++Y KYL
Sbjct: 148 MDDGADLHAYIHEKVSSKLD-IYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYL 206
Query: 187 FDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIK 246
FDNRYGTGQS DGI+RATN+L+AGK VV GYGW GRGIA R RG+GA VIV EVDPI+
Sbjct: 207 FDNRYGTGQSAIDGILRATNILIAGKIAVVAGYGWVGRGIANRLRGMGARVIVTEVDPIR 266
Query: 247 ALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWK 306
ALEA MDGF VM + EA+K+GDIFVTATGN K IR EH MKDGAI++NAGHF+VE+
Sbjct: 267 ALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHFNVEVDV 326
Query: 307 PDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKA 366
L+E AV++ N RP V EY L +G+R+YLLADGRLVNL AA+GHP+E+MDMSFA QA A
Sbjct: 327 KGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALA 386
Query: 367 AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
EY+ +N +LE +VY +P E+D VARIKL+SMGI I+ELTEEQK+YLE W+ GT
Sbjct: 387 VEYLVKNRGKLEKKVYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWKSGT 442
>sp|P50252|SAHH_SULSO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|2118058|pir||S58193
adenosylhomocysteinase (EC 3.3.1.1) [validated] -
Sulfolobus solfataricus >gi|2129448|pir||JC5156
S-adenosylhomocysteine hydrolase (EC 3.-.-.-) -
Sulfolobus solfataricus >gi|927551|emb|CAA90536.1|
(Z50174) S-adenosylhomocysteine hydrolase [Sulfolobus
solfataricus]
Length = 417
Score = 515 bits (1311), Expect = e-145
Identities = 256/416 (61%), Positives = 324/416 (77%), Gaps = 2/416 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y +KD+SLA EG K+I+W R MP L IR+ F+ +KP KG+ I+A LH+ +TA L+ T
Sbjct: 3 YKIKDLSLASEGKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKETAALVKT 62
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIR-PNII 126
LK GGA V+ A SNPLSTQDDV AAL +EG+ V+A +GE++ EYY + + I PNI+
Sbjct: 63 LKIGGANVALAGSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIV 122
Query: 127 IDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYL 186
+DDGAD+ + +H + LD I+G +EETTTGVIRL+AME+D VL++P++AVN++Y KYL
Sbjct: 123 MDDGADLHAYIHEKVSSKLD-IYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYL 181
Query: 187 FDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIK 246
FDNRYGTGQS DGI+RATN+L+AGK VV GYGW GRGIA R RG+GA VIV EVDPI+
Sbjct: 182 FDNRYGTGQSAIDGILRATNILIAGKIAVVAGYGWVGRGIANRLRGMGARVIVTEVDPIR 241
Query: 247 ALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWK 306
ALEA MDGF VM + EA+K+GDIFVTATGN K IR EH MKDGAI++NAGHF+VE+
Sbjct: 242 ALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHFNVEVDV 301
Query: 307 PDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKA 366
L+E AV++ N RP V EY L +G+R+YLLADGRLVNL AA+GHP+E+MDMSFA QA A
Sbjct: 302 KGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALA 361
Query: 367 AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
EY+ +N +LE +VY +P E+D VARIKL+SMGI I+ELTEEQK+YLE W+ GT
Sbjct: 362 VEYLVKNRGKLEKKVYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWKSGT 417
>sp|O27673|SAHH_METTH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435514|pir||F69085
adenosylhomocysteinase (EC 3.3.1.1) - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622763|gb|AAB86109.1| (AE000922)
S-adenosylhomocysteine hydrolase [Methanobacterium
thermoautotrophicum]
Length = 417
Score = 506 bits (1289), Expect = e-142
Identities = 257/417 (61%), Positives = 315/417 (74%), Gaps = 4/417 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y VKDISLAP+G KKI WV MPVL+ I+ +F E+KPFKGV I + LHLE KT L LT
Sbjct: 3 YKVKDISLAPQGEKKIRWVQEHMPVLERIKSDFSEEKPFKGVTIGSCLHLEPKTINLGLT 62
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIII 127
L+AGGA+V+ NPLSTQDD AA AK G+ +Y RGE+ EEYYE +++ LD P I+I
Sbjct: 63 LQAGGAEVAMTGCNPLSTQDDATAAGAKMGLNMYGWRGETNEEYYENIHRVLDHEPEILI 122
Query: 128 DDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLF 187
DDGADM+ LVH ER ELLD I GA EETTTG+ RLRAM D L+FPV+AVND+Y KYLF
Sbjct: 123 DDGADMIFLVHRERPELLDGIIGACEETTTGINRLRAMAADGALKFPVMAVNDAYTKYLF 182
Query: 188 DNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKA 247
DNRYGTGQST+D IM TN+L+AGK VVV GYGWCGRGIAMRA GLGA+VIV EVDPI+A
Sbjct: 183 DNRYGTGQSTFDSIMGTTNMLIAGKTVVVCGYGWCGRGIAMRAEGLGASVIVTEVDPIRA 242
Query: 248 LEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKP 307
LEARMDGF VM + +A K DI +TATGN + F MKDG +MAN+GHF+VEI +
Sbjct: 243 LEARMDGFRVMKVSDAVKEADILITATGNTDVVSESEFMNMKDGCVMANSGHFNVEINRE 302
Query: 308 DLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVA--ADGHPAEIMDMSFALQAK 365
LEEL+ E + ++ + + DGR++YLLA+GRLVNL + GHPAEIMDMSFA+QA
Sbjct: 303 ALEELSRETGKVKEDIEVFIMPDGRKIYLLAEGRLVNLASERGQGHPAEIMDMSFAMQAL 362
Query: 366 AAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
+A ++ + E+ +P VY P EID MVAR+KL +MGI I+ELTE+Q+ YLE+W+ GT
Sbjct: 363 SARHLLQ--EKPDPGVYRAPDEIDLMVARMKLDAMGIEIDELTEKQRLYLENWEEGT 417
>gi|11499582 S-adenosylhomocysteinase hydrolase (ahcY-2) [Archaeoglobus
fulgidus] >gi|6094227|sp|O28279|SAHH_ARCFU
ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE
HYDROLASE) (ADOHCYASE) >gi|7435515|pir||G69499
adenosylhomocysteinase (EC 3.3.1.1) homolog ahcY-2 -
Archaeoglobus fulgidus >gi|2648535|gb|AAB89252.1|
(AE000964) S-adenosylhomocysteinase hydrolase (ahcY-2)
[Archaeoglobus fulgidus]
Length = 405
Score = 506 bits (1288), Expect = e-142
Identities = 252/405 (62%), Positives = 311/405 (76%), Gaps = 1/405 (0%)
Query: 18 EGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSA 77
EG +KI+W R+M VL IR +F +++P +G + LH+E KTA L+ TL GA+V+
Sbjct: 2 EGFRKIEWAERYMKVLGKIREQFRKERPLEGFTVGMALHVEAKTAVLVRTLVDAGAEVAI 61
Query: 78 AASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSLV 137
NP+STQDDV AL + G+ YA RG EEYYE + + P+I+IDDGAD++ L+
Sbjct: 62 TGCNPMSTQDDVADALRESGIACYAKRGMDVEEYYEALRNVIRAEPDIVIDDGADLIFLL 121
Query: 138 HTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQST 197
H E + +++ GASEETTTGVIRLRAMER+ VL+FPVIAVND+Y KYLFDNRYGTGQS
Sbjct: 122 HGEMESYAEKVKGASEETTTGVIRLRAMEREGVLKFPVIAVNDAYTKYLFDNRYGTGQSA 181
Query: 198 WDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLV 257
DG++RATNLL+AGK VVV GYGWCGRGIAMRARG+GA+V+V EVD I+ALEA MDGF V
Sbjct: 182 IDGVIRATNLLMAGKIVVVAGYGWCGRGIAMRARGMGASVVVTEVDEIRALEAVMDGFRV 241
Query: 258 MSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEIS 317
M M++AAKIGDIF+TATGN IR EH LMKDGAI+ANAGHF+VEI P LE +A
Sbjct: 242 MRMEDAAKIGDIFITATGNRDIIREEHIRLMKDGAILANAGHFNVEIDIPALERMAKAKR 301
Query: 318 NPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERL 377
R VTEY L D +R+YLLA+GRLVNLVAADGHP E+MDMSFA QA AA+YI EN ++L
Sbjct: 302 EARKYVTEYDLGD-KRVYLLAEGRLVNLVAADGHPVEVMDMSFANQALAAKYIAENWQKL 360
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
E +VY LP E+D MVAR+KL+SMG+ I++LTEEQ +YL W+ GT
Sbjct: 361 ERKVYRLPEELDRMVARMKLESMGVEIDQLTEEQVRYLSDWRCGT 405
>sp|O51933|SAHH_THEMA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435518|pir||B72409
adenosylhomocysteinase - Thermotoga maritima (strain
MSB8) >gi|4980667|gb|AAD35265.1|AE001702_5 (AE001702)
adenosylhomocysteinase [Thermotoga maritima]
Length = 404
Score = 496 bits (1264), Expect = e-139
Identities = 246/401 (61%), Positives = 300/401 (74%)
Query: 19 GMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAA 78
G KI+WVSR+MP+L I E+ +KP G + ++HLE KTA+L +TL GAKV
Sbjct: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAITLSKLGAKVVIT 63
Query: 79 ASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSLVH 138
SNPLSTQDDV AL +G+ VYA R + Y E + K LD RP+ IIDDG D+ + H
Sbjct: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123
Query: 139 TERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTW 198
TER+E+L+ + G SEETTTGV RL+A+E LR PVIAVNDS MKYLFDNRYGTGQSTW
Sbjct: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183
Query: 199 DGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVM 258
D IMR TNLLVAGKNVVV GYGWCGRGIA+RA GLGA VIV EVDP+KA+EA MDGF VM
Sbjct: 184 DAIMRNTNLLVAGKNVVVAGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGFTVM 243
Query: 259 SMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISN 318
MKEA KI D +TA+GN + +E +KDGA++ANAGHF+VEI LEE+AVE
Sbjct: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303
Query: 319 PRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLE 378
RPNVT Y L++G+ ++LLA+GRLVNL A DGHP EIMD+SFALQ A Y+ ENH ++
Sbjct: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMS 363
Query: 379 PRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQ 419
P+VY+LP EIDE VAR+KL S+G+ I+ELTE+Q++YL SWQ
Sbjct: 364 PKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404
>gb|AAC01562.1| (AF013268) S adenosylhomocysteine hydrolase [Thermotoga maritima]
Length = 404
Score = 496 bits (1263), Expect = e-139
Identities = 246/401 (61%), Positives = 300/401 (74%)
Query: 19 GMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAA 78
G KI+WVSR+MP+L I E+ +KP G + ++HLE KTA+L +TL GAKV
Sbjct: 4 GEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLERKTAYLAVTLSKLGAKVVIT 63
Query: 79 ASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSLVH 138
SNPLSTQDDV AL +G+ VYA R + Y E + K LD RP+ IIDDG D+ + H
Sbjct: 64 GSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLMKVLDERPDFIIDDGGDLTVISH 123
Query: 139 TERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTW 198
TER+E+L+ + G SEETTTGV RL+A+E LR PVIAVNDS MKYLFDNRYGTGQSTW
Sbjct: 124 TEREEVLENLKGVSEETTTGVRRLKALEETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTW 183
Query: 199 DGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVM 258
D IMR TNLLVAGKNVVV GYGWCGRGIA+RA GLGA VIV EVDP+KA+EA MDGF VM
Sbjct: 184 DAIMRNTNLLVAGKNVVVAGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGFTVM 243
Query: 259 SMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISN 318
MKEA KI D +TA+GN + +E +KDGA++ANAGHF+VEI LEE+AVE
Sbjct: 244 PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFE 303
Query: 319 PRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLE 378
RPNVT Y L++G+ ++LLA+GRLVNL A DGHP EIMD+SFALQ A Y+ ENH ++
Sbjct: 304 ARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRKMS 363
Query: 379 PRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQ 419
P+VY+LP EIDE VAR+KL S+G+ I+ELTE+Q++YL SWQ
Sbjct: 364 PKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLRSWQ 404
>sp|P74008|SAHH_SYNY3 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435516|pir||S75518
adenosylhomocysteinase (EC 3.3.1.1) - Synechocystis sp.
(strain PCC 6803) >gi|1653163|dbj|BAA18079.1| (D90911)
S-adenosylhomocysteine hydrolase [Synechocystis sp.]
Length = 425
Score = 470 bits (1197), Expect = e-131
Identities = 230/416 (55%), Positives = 305/416 (73%), Gaps = 1/416 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y +KDISLAP+G ++I+W +R MPVL+ IR F ++KPF G+R+ A H+ +TA L +
Sbjct: 10 YDIKDISLAPQGRQRIEWAAREMPVLKQIRERFAQEKPFAGIRLVACCHVTTETANLAIA 69
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKE-GVKVYAIRGESKEEYYEFMNKALDIRPNII 126
L AGGA ASNPLSTQDDV A L + G+ VYAI+GE E Y+ + ALD RPNII
Sbjct: 70 LHAGGADSLLIASNPLSTQDDVAACLVADYGIPVYAIKGEDNETYHRHVQIALDHRPNII 129
Query: 127 IDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYL 186
IDDG+D+V+ + ER+ L +I G +EETTTG++RLRAM D VL FP + VND+ K+
Sbjct: 130 IDDGSDVVATLVQERQHQLSDIIGTTEETTTGIVRLRAMFNDGVLTFPAMNVNDADTKHF 189
Query: 187 FDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIK 246
+DNRYGTGQST DGI+RATN+L+AGK +VV GYGWCG+G+AMRA+G+GA VIV E+ P+
Sbjct: 190 YDNRYGTGQSTLDGIIRATNILLAGKTIVVAGYGWCGKGVAMRAKGMGADVIVTEISPVP 249
Query: 247 ALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWK 306
A+EA MDGF VM M EAA GDIF+T TGN IR EHF +MKDGAI+ N+GHFD+EI
Sbjct: 250 AIEAAMDGFRVMPMAEAAHQGDIFITVTGNKHVIRPEHFAVMKDGAIVCNSGHFDIEIDL 309
Query: 307 PDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKA 366
L+E A E+ R +Y L +G+ + ++ +GRLVNL AA+GHP+ +MDMSFA QA A
Sbjct: 310 KSLKEQAKEVKEVRNFTEQYILPNGKSIIVIGEGRLVNLAAAEGHPSAVMDMSFANQALA 369
Query: 367 AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
E++ +N +LEP ++ +P E+D+ +AR+KLQ+MGI I+ LT EQ +Y+ SW GT
Sbjct: 370 CEHLVKNKGQLEPGMHSIPVEVDQEIARLKLQAMGIAIDSLTPEQVEYINSWASGT 425
>pir||B72649 probable adenosylhomocysteinase APE0624 - Aeropyrum pernix (strain
K1) >gi|5104279|dbj|BAA79594.1| (AP000060) 399aa long
hypothetical adenosylhomocysteinase [Aeropyrum pernix]
Length = 399
Score = 460 bits (1172), Expect = e-128
Identities = 230/398 (57%), Positives = 295/398 (73%)
Query: 22 KIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAAASN 81
+I+W R MPVL +R KP GVR+AA LH+ +TA L+ TL+ GA+V A SN
Sbjct: 2 QIEWAERHMPVLMRLRSSMGGDKPLSGVRVAACLHVTKETAVLVETLRKWGAEVYLAPSN 61
Query: 82 PLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSLVHTER 141
PLSTQD+V AALA+ G+ V+A RG + EEY ++ P+I+IDDGAD+ L+H E
Sbjct: 62 PLSTQDEVAAALAEAGIGVFAWRGMTPEEYKWALSTVAGREPDIVIDDGADLHVLLHEEM 121
Query: 142 KELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
+ + +++WG +EETTTGVIRLRA+ER+ L +PVIAVND+ K++FDNRYGTGQST DG+
Sbjct: 122 RSVGEKVWGGTEETTTGVIRLRALEREGRLLYPVIAVNDALTKFMFDNRYGTGQSTVDGV 181
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
+RATN+L+AGK VVV GYGW GRGIA R RG+GA V+V EVDP++ALEA MDGF V +M
Sbjct: 182 LRATNILIAGKTVVVAGYGWVGRGIAARFRGMGAKVVVTEVDPVRALEAAMDGFTVTTMD 241
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRP 321
EAA +GD+F+TATGNI I H E MKDGAI+ANAGHF+VEI LEE++V R
Sbjct: 242 EAASLGDVFITATGNINVIDARHMEKMKDGAILANAGHFNVEINVAALEEMSVSKRRVRR 301
Query: 322 NVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEPRV 381
+ EY+L DGRRLYL+ +GRLVNLVAA+GHP+E+MDMSF+ QA A I RLE RV
Sbjct: 302 YLDEYRLPDGRRLYLIGEGRLVNLVAAEGHPSEVMDMSFSNQALAVLKIAGERGRLEKRV 361
Query: 382 YVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQ 419
+ + R DEMVAR+KL++MG+ I+ LTEEQK YL+ W+
Sbjct: 362 HRVERIQDEMVARLKLETMGVRIDSLTEEQKLYLQKWK 399
>emb|CAC11611.1| (AL445064) probable adenosylhomocysteinase [Thermoplasma
acidophilum]
Length = 410
Score = 446 bits (1134), Expect = e-124
Identities = 216/406 (53%), Positives = 293/406 (71%), Gaps = 1/406 (0%)
Query: 18 EGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSA 77
+G ++ W MPV+ IR+ F+ +KPFKG+++A LH+E KT L LK GGA+V
Sbjct: 5 KGFLRLAWARDHMPVIAEIRKRFQAEKPFKGIKVAMALHVEAKTGIFALLLKEGGAEVKM 64
Query: 78 AASNPLSTQDDVVAALAKE-GVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSL 136
A+ NPLS+ D VV +L ++ G+ V+A +GE+ EEYYE++++ LD++P+IIIDDG D+ +
Sbjct: 65 ASCNPLSSDDSVVQSLKEDYGMPVFARKGETSEEYYEYLHRTLDVQPDIIIDDGGDLTKI 124
Query: 137 VHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQS 196
VHTERK+L I G +EETTTGV RLRAMER VL FP+ VND+ MK+LFDNRYGTGQS
Sbjct: 125 VHTERKDLAKNILGGNEETTTGVQRLRAMERSGVLLFPMFDVNDANMKHLFDNRYGTGQS 184
Query: 197 TWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFL 256
T DGIM ATNLL+AG+ VVV GYG+CGRGIAMR +G+GA VIV E+DPIKA EA MDGF
Sbjct: 185 TLDGIMNATNLLIAGRTVVVAGYGYCGRGIAMRLKGMGANVIVTEIDPIKANEAIMDGFQ 244
Query: 257 VMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEI 316
V M A + D+ +TATG ++ E + K ++ANAGHF+ E+ ++E+ ++E+
Sbjct: 245 VRRMNNAIRDADMVITATGMKDVVKYEDALVAKKNIVLANAGHFNNEVAVSEIEKRSLEV 304
Query: 317 SNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHER 376
+ R V Y+L++G + ++ADGRLVNL A GHP EIMD+SFALQA AEY+ +NH++
Sbjct: 305 NEVREFVKRYRLENGNTVDIIADGRLVNLAAGQGHPVEIMDLSFALQALTAEYLVKNHDK 364
Query: 377 LEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
LE +VY +P +ID VA I+L+ G +++L EEQ KYL SW GT
Sbjct: 365 LERKVYPVPADIDRYVAEIRLKQFGGELDQLNEEQIKYLNSWDEGT 410
>gb|AAG20371.1| (AE005110) adenosylhomocysteinase; AchY [Halobacterium sp. NRC-1]
Length = 427
Score = 387 bits (984), Expect = e-106
Identities = 202/407 (49%), Positives = 261/407 (63%), Gaps = 3/407 (0%)
Query: 19 GMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAA 78
G KIDW MP+L +R EF+ +P G I +H+E KTA L+ T+ GA+++
Sbjct: 21 GRAKIDWAFEHMPILSALREEFDANQPLAGETIGMAMHVEAKTAALVETMADAGAEIAIT 80
Query: 79 ASNPLSTQDDVVAAL-AKEGVKVYAIRGESKEEYYEFMNKALDIRPNIIIDDGADMVSLV 137
NPLST D V AAL A E + YA RG E YY+ ++ L P + +DDG D+V V
Sbjct: 81 GCNPLSTHDGVSAALDAHESITSYAERGAEGEAYYDAIDAVLAHEPTVTVDDGGDLVFRV 140
Query: 138 HTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQST 197
H + EL+D I G +EETTTGV RLRAM+ D L +PV AVND+ MK LFDN +GTG+S
Sbjct: 141 HEDHPELIDTIIGGTEETTTGVHRLRAMDDDDALEYPVFAVNDTPMKRLFDNVHGTGESA 200
Query: 198 WDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLV 257
I TNL AGK+VVV GYG CGRG+A +A G A VIV EV+P +ALEA M+G+ V
Sbjct: 201 LANIAMTTNLSWAGKDVVVAGYGDCGRGVAKKAAGQNANVIVTEVEPRRALEAHMEGYDV 260
Query: 258 MSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEIS 317
M M EAA++GD+F+T TGN I R HFE M DG ++ANAGHFDVE+ L ELAV
Sbjct: 261 MPMAEAAEVGDVFLTTTGNKNVITRAHFERMDDGVVLANAGHFDVEVNLDHLSELAVSER 320
Query: 318 NPRPNVTEYKLKDGRRLYLLADGRLVNLVA--ADGHPAEIMDMSFALQAKAAEYIKENHE 375
R V EY+L DGRRL +LA+GRLVNL + GHP +MD SF +QA + N E
Sbjct: 321 EAREGVREYELADGRRLNVLAEGRLVNLASPIGLGHPVGVMDQSFGVQAVCVRELVANRE 380
Query: 376 RLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHGT 422
V+ +P E+D +A IKL + G+ + LT++Q +Y++SWQHGT
Sbjct: 381 EYAAGVHNVPDELDIEIAEIKLAAEGVEYDALTDDQAEYMDSWQHGT 427
>gi|9951915 S-adenosylhomocysteine hydrolase; adenosylhomocysteinase [Homo
sapiens] >gi|11420563|ref|XP_009475.1|
S-adenosylhomocysteine hydrolase [Homo sapiens]
>gi|280756|pir||A43629 adenosylhomocysteinase (EC
3.3.1.1) - human >gi|178279|gb|AAA51682.1| (M61832)
S-adenosylhomocysteine hydrolase [Homo sapiens]
>gi|10241524|emb|CAC09528.1| (AL356299) bK3216D2.1.2
(S-adenosylhomocysteine hydrolase (SAHH), isoform 2)
[Homo sapiens]
Length = 432
Score = 347 bits (881), Expect = 1e-94
Identities = 193/411 (46%), Positives = 256/411 (61%), Gaps = 3/411 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K +D MP L +R + KP KG RIA LH+ ++TA L+ T
Sbjct: 7 YKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L GA+V ++ N STQD AA+AK G+ VYA +GE+ EEY + + L + N
Sbjct: 67 LVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLN 126
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
+I+DDG D+ +L+HT+ +LL I G SEETTTGV L M + +L+ P I VNDS K
Sbjct: 127 MILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTK 186
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++++AGK VV GYG G+G A RG GA VI+ E+DP
Sbjct: 187 SKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 246
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
I AL+A M+G+ V +M EA + G+IFVT TG I I HFE MKD AI+ N GHFDVEI
Sbjct: 247 INALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEI 306
Query: 305 WKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQA 364
L E AVE N +P V Y+LK+GRR+ LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 307 DVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQV 366
Query: 365 KAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + + ++ V+ LP+++DE VA L + + + +LTE+Q +YL
Sbjct: 367 MAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417
>gi|7709980 S-adenosylhomocysteine hydrolase [Mus musculus]
>gi|1710839|sp|P50247|SAHH_MOUSE ADENOSYLHOMOCYSTEINASE
(S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE) (LIVER
COPPER BINDING PROTEIN) (CUBP) >gi|904132|gb|AAA70378.1|
(L32836) copper binding protein [Mus musculus]
Length = 432
Score = 346 bits (877), Expect = 4e-94
Identities = 193/411 (46%), Positives = 255/411 (61%), Gaps = 3/411 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K +D MP L +R + KP KG RIA LH+ ++TA L+ T
Sbjct: 7 YKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L A GA+V ++ N STQD AA+AK G+ V+A +GE+ EEY + + L + N
Sbjct: 67 LVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLN 126
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
+I+DDG D+ +L+HT+ +LL I G SEETTTGV L M + +L P I VNDS K
Sbjct: 127 MILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILNVPAINVNDSVTK 186
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++++AGK VV GYG G+G A RG GA VI+ E+DP
Sbjct: 187 SKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 246
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
I AL+A M+G+ V +M EA K G+IFVT TG + I HFE MKD AI+ N GHFDVEI
Sbjct: 247 INALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEI 306
Query: 305 WKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQA 364
L E AVE N +P V Y LK+GRR+ LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 307 DVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQV 366
Query: 365 KAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + + ++ V+ LP+++DE VA L + + + +LTE+Q +YL
Sbjct: 367 MAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417
>gi|8392878 S-adenosylhomocysteine hydrolase [Rattus norvegicus]
>gi|134185|sp|P10760|SAHH_RAT ADENOSYLHOMOCYSTEINASE
(S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE)
>gi|91925|pir||A26583 adenosylhomocysteinase (EC
3.3.1.1) - rat >gi|202804|gb|AAA40705.1| (M15185)
S-adenosyl-L-homocysteine hydrolase (EC 3.3.1.1) [Rattus
sp.] >gi|1185363|gb|AAA92043.1| (U14937)
S-adenosyl-L-homocysteine hydrolase [Rattus norvegicus]
Length = 432
Score = 346 bits (877), Expect = 4e-94
Identities = 192/411 (46%), Positives = 255/411 (61%), Gaps = 3/411 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K +D MP L +R + KP KG RIA LH+ ++TA L+ T
Sbjct: 7 YKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L A GA+V ++ N STQD AA+AK G+ V+A +GE+ EEY + + L + N
Sbjct: 67 LVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLN 126
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
+I+DDG D+ +L+HT+ +LL I G SEETTTGV L M + +L+ P I VNDS K
Sbjct: 127 MILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTK 186
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++++AGK VV GYG G+G A RG GA VI+ E+DP
Sbjct: 187 SKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 246
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
I AL+A M+G+ V +M EA K G+IFVT TG + I HFE MKD AI+ N GHFDVEI
Sbjct: 247 INALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEI 306
Query: 305 WKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQA 364
L E AVE N +P V Y LK+G R+ LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 307 DVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQV 366
Query: 365 KAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + + ++ V+ LP+++DE VA L + + + +LTE+Q +YL
Sbjct: 367 MAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417
>pdb|1B3R|A Chain A, Rat Liver S-Adenosylhomocystein Hydrolase
>gi|4139572|pdb|1B3R|B Chain B, Rat Liver
S-Adenosylhomocystein Hydrolase >gi|4139573|pdb|1B3R|C
Chain C, Rat Liver S-Adenosylhomocystein Hydrolase
>gi|4139574|pdb|1B3R|D Chain D, Rat Liver
S-Adenosylhomocystein Hydrolase
Length = 431
Score = 346 bits (877), Expect = 4e-94
Identities = 192/411 (46%), Positives = 255/411 (61%), Gaps = 3/411 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K +D MP L +R + KP KG RIA LH+ ++TA L+ T
Sbjct: 6 YKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIET 65
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L A GA+V ++ N STQD AA+AK G+ V+A +GE+ EEY + + L + N
Sbjct: 66 LVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLN 125
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
+I+DDG D+ +L+HT+ +LL I G SEETTTGV L M + +L+ P I VNDS K
Sbjct: 126 MILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTK 185
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++++AGK VV GYG G+G A RG GA VI+ E+DP
Sbjct: 186 SKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 245
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
I AL+A M+G+ V +M EA K G+IFVT TG + I HFE MKD AI+ N GHFDVEI
Sbjct: 246 INALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEI 305
Query: 305 WKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQA 364
L E AVE N +P V Y LK+G R+ LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 306 DVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQV 365
Query: 365 KAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + + ++ V+ LP+++DE VA L + + + +LTE+Q +YL
Sbjct: 366 MAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 416
>sp|P23526|SAHH_HUMAN ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|178277|gb|AAA51681.1| (M61831)
S-adenosylhomocysteine hydrolase [Homo sapiens]
Length = 432
Score = 345 bits (876), Expect = 5e-94
Identities = 192/411 (46%), Positives = 256/411 (61%), Gaps = 3/411 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K +D MP L +R + KP KG RIA LH+ ++TA L+ T
Sbjct: 7 YKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L GA+V ++ N STQ+ AA+AK G+ VYA +GE+ EEY + + L + N
Sbjct: 67 LVTLGAEVQWSSCNIFSTQNHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLN 126
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
+I+DDG D+ +L+HT+ +LL I G SEETTTGV L M + +L+ P I VNDS K
Sbjct: 127 MILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTK 186
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++++AGK VV GYG G+G A RG GA VI+ E+DP
Sbjct: 187 SKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 246
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
I AL+A M+G+ V +M EA + G+IFVT TG I I HFE MKD AI+ N GHFDVEI
Sbjct: 247 INALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEI 306
Query: 305 WKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQA 364
L E AVE N +P V Y+LK+GRR+ LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 307 DVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQV 366
Query: 365 KAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + + ++ V+ LP+++DE VA L + + + +LTE+Q +YL
Sbjct: 367 MAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417
>sp|P51893|SAH1_XENLA ADENOSYLHOMOCYSTEINASE 1 (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE 1)
(ADOHCYASE 1) >gi|1079279|pir||JC2480
adenosylhomocysteinase (EC 3.3.1.1) - African clawed
frog >gi|558508|gb|AAA65963.1| (L35559) adenine
homocysteine hydrolase [Xenopus laevis]
Length = 433
Score = 345 bits (876), Expect = 5e-94
Identities = 194/412 (47%), Positives = 257/412 (62%), Gaps = 4/412 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DISLA G K I+ MP L +R E KP KG RIA LH+ ++TA L+ T
Sbjct: 7 YKVADISLADWGRKAIEIAENEMPGLMKMREMHSESKPLKGARIAGCLHMTLQTAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIRP- 123
L A GA+V ++ N STQD AA+AK GV VYA +GE+ EEY + + + D +P
Sbjct: 67 LTALGAEVQWSSCNIFSTQDHAAAAIAKTGVPVYAWKGETDEEYIWCIEQTIYFKDGKPL 126
Query: 124 NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYM 183
N+I+DDG D+ +LVH++ +LL I G SEETTTGV L M+ L+ P I VNDS
Sbjct: 127 NMILDDGGDLTNLVHSKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQVPAINVNDSVT 186
Query: 184 KYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVD 243
K FDN YG +S DGI RAT++++AGK VV GYG G+G A R GA VI+ E+D
Sbjct: 187 KSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRAFGARVIITEID 246
Query: 244 PIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVE 303
PI AL+A M+G+ V +M EA+K G+IFVT TG + HFE MKD +I+ N GHFD+E
Sbjct: 247 PINALQAAMEGYEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDSIVCNIGHFDIE 306
Query: 304 IWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ 363
+ L E AV+ N +P V Y LK+GR + LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 307 LDVKWLNENAVKKVNIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHPSFVMSNSFTNQ 366
Query: 364 AKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + N ++ VY LP+++DE VA L +G+ + +LT++Q KYL
Sbjct: 367 VMAQIELWTNTDKYPVGVYFLPKKLDEAVAAAHLDKLGVKLTKLTDKQAKYL 418
>sp|O93477|SAH2_XENLA ADENOSYLHOMOCYSTEINASE 2 (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE 2)
(ADOHCYASE 2) >gi|3413509|emb|CAA07706.1| (AJ007835)
S-adenosyl-L-homocysteine hydrolase [Xenopus laevis]
Length = 433
Score = 345 bits (876), Expect = 5e-94
Identities = 193/412 (46%), Positives = 257/412 (61%), Gaps = 4/412 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DISLA G K I+ MP L +R + E KP KG RIA LH+ ++TA L+ T
Sbjct: 7 YKVADISLADWGRKAIEIAENEMPGLMKMREMYSESKPLKGARIAGCLHMTLQTAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIRP- 123
L A GA+V ++ N STQD AA+AK GV VYA +GE+ EEY + + + D +P
Sbjct: 67 LTAIGAEVQWSSCNIFSTQDHAAAAIAKTGVPVYAWKGETDEEYIWCIEQTIYFKDGKPL 126
Query: 124 NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYM 183
N+I+DDG D+ +LVHT+ +LL I G SEETTTGV L M+ L+ P I VNDS
Sbjct: 127 NMILDDGGDLTNLVHTKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQVPAINVNDSVT 186
Query: 184 KYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVD 243
K FDN YG +S DGI RAT++++AGK VV GYG G+G A R GA V++ E+D
Sbjct: 187 KSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRAFGARVLITEID 246
Query: 244 PIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVE 303
PI AL+A M+G+ V +M EA+K G+IFVT TG + HFE MKD +I+ N GHFDVE
Sbjct: 247 PINALQAAMEGYEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDSIVCNIGHFDVE 306
Query: 304 IWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ 363
+ L + A + N +P V Y LK+GR + LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 307 LDVKWLNDNAAKKINIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHPSFVMSNSFTNQ 366
Query: 364 AKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + N ++ VY LP+++DE VA L +G+ + +LT++Q KYL
Sbjct: 367 VMAQIELWTNTDKYPVGVYFLPKKLDEAVAAAHLDKLGVKLTKLTDKQAKYL 418
>sp|O13639|SAHH_SCHPO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7490081|pir||T40763
adenosylhomocysteinase - fission yeast
(Schizosaccharomyces pombe) >gi|2257533|dbj|BAA21427.1|
(AB004537) ADENOSYL HOMOCYS TEINASE [Schizosaccharomyces
pombe] >gi|2950505|emb|CAA17833.1| (AL022072)
adenosylhomocysteinase [Schizosaccharomyces pombe]
Length = 433
Score = 339 bits (860), Expect = 4e-92
Identities = 192/416 (46%), Positives = 260/416 (62%), Gaps = 5/416 (1%)
Query: 5 TSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFL 64
T +Y V DISLA G K+++ MP L +R ++ + +P KG RIA LH+ ++TA L
Sbjct: 3 TQNYKVADISLAAFGRKELEIAENEMPGLIAVREKYAKSQPLKGARIAGCLHMTIQTAVL 62
Query: 65 LLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP- 123
+ TL A GA+V+ ++ N STQD AA+A GV V+A +GE++EEY + + L P
Sbjct: 63 IETLVALGAEVTWSSCNIYSTQDHAAAAIAATGVPVFAWKGETEEEYLWCIEQQLKSFPS 122
Query: 124 ----NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVN 179
N+I+DDG D+ +LVH ELL +I G SEETTTGV L M ++ L+ P I VN
Sbjct: 123 GKPLNMILDDGGDLTALVHERHPELLVDIRGISEETTTGVHNLYKMFKENKLKVPAINVN 182
Query: 180 DSYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIV 239
DS K FDN +G +S DGI RAT++++AGK VV G+G G+G + R GA VIV
Sbjct: 183 DSVTKSKFDNLFGCKESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCSTSLRSQGARVIV 242
Query: 240 VEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGH 299
EVDPI AL+A MDGF V +M+EA K G IFVT TG IR EHF MK+ +I+ N GH
Sbjct: 243 TEVDPINALQAAMDGFEVTTMEEAVKEGQIFVTTTGCRDIIRGEHFNEMKEDSIVCNIGH 302
Query: 300 FDVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMS 359
FDVEI L+ A ++ N +P V Y+LK+GR + LLADGRLVNL A GHP+ +M S
Sbjct: 303 FDVEIDVAWLKANAKDVVNIKPQVDRYELKNGRHIILLADGRLVNLGCATGHPSFVMSCS 362
Query: 360 FALQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
F Q A + ++ V++LP+++DE VAR+ L +G+ + LT Q YL
Sbjct: 363 FTNQVLAQIALWTDNTSYPLGVHMLPKKLDEEVARLHLGKLGVKLTTLTSVQSDYL 418
>pdb|1A7A|A Chain A, Structure Of Human Placental S-Adenosylhomocysteine
Hydrolase: Determination Of A 30 Selenium Atom
Substructure From Data At A Single Wavelength
>gi|4929855|pdb|1A7A|B Chain B, Structure Of Human
Placental S-Adenosylhomocysteine Hydrolase:
Determination Of A 30 Selenium Atom Substructure From
Data At A Single Wavelength
Length = 432
Score = 328 bits (832), Expect = 7e-89
Identities = 186/411 (45%), Positives = 246/411 (59%), Gaps = 3/411 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K +D P L R + KP KG RIA LH ++TA L+ T
Sbjct: 7 YKVADIGLAAWGRKALDIAENEXPGLXRXRERYSASKPLKGARIAGCLHXTVETAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L GA+V ++ N STQ+ AA+AK G+ VYA +GE+ EEY + + L + N
Sbjct: 67 LVTLGAEVQWSSCNIFSTQNHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLN 126
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
I+DDG D+ +L+HT+ +LL I G SEETTTGV L + +L+ P I VNDS K
Sbjct: 127 XILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKXXANGILKVPAINVNDSVTK 186
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++ +AGK VV GYG G+G A RG GA VI+ E+DP
Sbjct: 187 SKFDNLYGCRESLIDGIKRATDVXIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 246
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
I AL+A +G+ V + EA + G+IFVT TG I I HFE KD AI+ N GHFDVEI
Sbjct: 247 INALQAAXEGYEVTTXDEACQEGNIFVTTTGCIDIILGRHFEQXKDDAIVCNIGHFDVEI 306
Query: 305 WKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQA 364
L E AVE N +P V Y+LK+GRR+ LLA+GRLVNL A GHP+ + SF Q
Sbjct: 307 DVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAXGHPSFVXSNSFTNQV 366
Query: 365 KAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + + ++ V+ LP+++DE VA L + + + +LTE+Q +YL
Sbjct: 367 XAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYL 417
>gi|6320882 putative S-adenosyl-L-homocysteine hydrolase; Sah1p [Saccharomyces
cerevisiae] >gi|730701|sp|P39954|SAHH_YEAST
ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE
HYDROLASE) (ADOHCYASE) >gi|1071879|pir||S50546
adenosylhomocysteinase (EC 3.3.1.1) - yeast
(Saccharomyces cerevisiae) >gi|603276|gb|AAB64578.1|
(U18796) Sam1p: Adenosylhomocysteinase [Saccharomyces
cerevisiae]
Length = 449
Score = 324 bits (822), Expect = 1e-87
Identities = 183/428 (42%), Positives = 266/428 (61%), Gaps = 19/428 (4%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y + DISLA G K+I+ MP L IR+ + + +P KG RIA LH+ ++TA L+
Sbjct: 7 NYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIE 66
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL-----DI 121
TL A GA+V+ ++ N STQD AA+A GV V+A +GE++EEY + + L +
Sbjct: 67 TLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNK 126
Query: 122 RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDS 181
+ N+I+DDG D+ +LVH + E+L++ +G SEETTTGV L M ++ L+ P I VNDS
Sbjct: 127 KLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDS 186
Query: 182 YMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 241
K FDN YG +S DGI RAT++++AGK VV GYG G+G A RG+GA V+V E
Sbjct: 187 VTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTE 246
Query: 242 VDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFD 301
+DPI AL+A M+G+ V++M++A+ IG +FVT TG I EHF M + AI+ N GHFD
Sbjct: 247 IDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFD 306
Query: 302 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 361
+EI L+ A E N +P V Y L GR + LLA+GRLVNL A GH + +M SF+
Sbjct: 307 IEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFS 366
Query: 362 LQAKAAEYIKENHER--------------LEPRVYVLPREIDEMVARIKLQSMGINIEEL 407
Q A + +++++ E V+VLP+ +DE VA+ L ++G+ + +L
Sbjct: 367 NQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKL 426
Query: 408 TEEQKKYL 415
++ Q +YL
Sbjct: 427 SKVQSEYL 434
>sp|O76757|SAHH_ANOGA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|3406737|gb|AAC29475.1| (AF080546)
S-adenosyl-L-homocysteine hydrolase [Anopheles gambiae]
Length = 432
Score = 324 bits (822), Expect = 1e-87
Identities = 190/412 (46%), Positives = 251/412 (60%), Gaps = 4/412 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DISLA G K+I MP L R+++ K +G RIA LH+ ++TA L+ T
Sbjct: 6 YKVADISLAEFGRKEIVLAENEMPGLMACRQKYGPLKILRGARIAGCLHMTIQTAVLIET 65
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIRP- 123
L GA+V ++ N STQD AA+ K GV VYA +GE+ EEY + + L D +P
Sbjct: 66 LIELGAEVQWSSCNIFSTQDHAAAAMVKAGVPVYAWKGETDEEYMWCIRQTLIFPDGKPL 125
Query: 124 NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYM 183
N+I+DDG D+ +LVH E ELL EI G SEETTTGV L M R+ L P I VNDS
Sbjct: 126 NMILDDGGDLTNLVHAEHPELLKEIRGLSEETTTGVHNLYKMFREGRLGMPAINVNDSVT 185
Query: 184 KYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVD 243
K FDN YG +S DGI RAT++++AGK VV GYG G+G A RG G V++ E+D
Sbjct: 186 KSKFDNLYGCRESLLDGIKRATDVMIAGKVCVVAGYGDVGKGCAQALRGSGGRVLITEID 245
Query: 244 PIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVE 303
PI AL+A M+G V +M+EA+K IFVT TG I EHF MKD +I+ N GHFD E
Sbjct: 246 PINALQAAMEGKEVTTMEEASKEAQIFVTTTGCTDIIMGEHFLNMKDDSIVCNIGHFDCE 305
Query: 304 IWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ 363
I L+E AVE N +P V Y+L +G + LLA+GRLVNL A GH + +M SF Q
Sbjct: 306 INVTWLQENAVEKVNIKPQVDRYRLANGNHIILLAEGRLVNLGCAMGHSSFVMSNSFTNQ 365
Query: 364 AKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + N E+ V+VLP+++D+ VA + L +G+ + +L+ Q +YL
Sbjct: 366 VLAQIELWTNREQYAIGVHVLPKKLDDEVAALHLDKLGVKLTKLSARQPEYL 417
>gb|AAF48453.1| (AE003499) Ahcy13 gene product [Drosophila melanogaster]
Length = 432
Score = 316 bits (801), Expect = 3e-85
Identities = 186/418 (44%), Positives = 248/418 (58%), Gaps = 4/418 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DISLA G K I MP L R+++ KP KG RI LH+ ++TA L+ T
Sbjct: 6 YKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIET 65
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIRP- 123
L GA+V ++ N STQD+ AA+A GV VYA +GE+ EEY + + L D +P
Sbjct: 66 LVELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPL 125
Query: 124 NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYM 183
N+I+DDG D+ +LVH + + L I G SEETTTGV L M ++ L P I VNDS
Sbjct: 126 NMILDDGGDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVT 185
Query: 184 KYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVD 243
K FDN YG +S DGI RAT++++AGK V GYG G+G A +G G VIV EVD
Sbjct: 186 KSKFDNLYGCRESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVD 245
Query: 244 PIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVE 303
PI AL+A M+G+ V +M+EA+K IFVT TG I H + M D AI+ N GHFD+E
Sbjct: 246 PINALQAAMEGYEVTTMEEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIE 305
Query: 304 IWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ 363
I L A E N +P V Y ++ G+ + LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 306 IDVDWLNANAKEKVNVKPQVDRYTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQ 365
Query: 364 AKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHG 421
A + ++ V+VLP+ +DE VA + L+ +G+ + +LTE+Q YL Q G
Sbjct: 366 VLAQIELWTKSDKYAVGVHVLPKILDEEVASLHLEKLGVKLTKLTEKQATYLGVSQTG 423
>sp|Q27580|SAHH_DROME ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|1200230|emb|CAA64892.1| (X95636)
S-adenosyl-L-homocysteine hydrolase [Drosophila
melanogaster]
Length = 431
Score = 313 bits (794), Expect = 2e-84
Identities = 186/418 (44%), Positives = 247/418 (58%), Gaps = 5/418 (1%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DISLA G K I MP L R+++ KP KG RI LH+ ++TA L+ T
Sbjct: 6 YKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIET 65
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIRP- 123
L GA+V ++ N STQD+ AA+A GV VYA +GE+ EEY + + L D +P
Sbjct: 66 LVELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPL 125
Query: 124 NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYM 183
N+I+DDG D+ +LVH + + L I G SEETTTGV L M ++ L P I VNDS
Sbjct: 126 NMILDDGGDLTNLVHEKFPQFLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVT 185
Query: 184 KYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVD 243
K FDN YG +S DGI RAT++++AGK V GYG G+G A +G G VIV EVD
Sbjct: 186 KSKFDNLYGCRESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVD 245
Query: 244 PIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVE 303
PI AL+A M+G+ V +M+E +K IFVT TG I H + M D I+ N GHFD+E
Sbjct: 246 PINALQAAMEGYEVTTMEEGSKEASIFVTTTGCRDIITSVHLQQMPDDRIVCNIGHFDIE 305
Query: 304 IWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ 363
I L A E N +P V Y +K G+ + LLA+GRLVNL ADGHP+ +M SF Q
Sbjct: 306 IDVDWLNANAKEKVNVKPQVDRYTMKSGKHIILLAEGRLVNLGCADGHPSFVMSNSFTNQ 365
Query: 364 AKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYLESWQHG 421
A + ++ V+VLP+ +DE VA + L+ +G+ + +LTE+Q YL Q G
Sbjct: 366 VLAQIELWTKSDK-SVGVHVLPKILDEEVASLHLEKLGVKLTKLTEKQATYLGVSQTG 422
>sp|P36889|SAHH_LEIDO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|159402|gb|AAA29265.1| (M76556)
S-adenosylhomocysteine hydrolase [Leishmania donovani]
Length = 437
Score = 312 bits (791), Expect = 5e-84
Identities = 185/421 (43%), Positives = 248/421 (57%), Gaps = 11/421 (2%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+DY VKDISLA G K I+ MP L +RRE+ +P KG +IA LH+ ++TA L+
Sbjct: 2 ADYKVKDISLAEWGRKAIELAENEMPGLMELRREYGPSQPLKGAKIAGCLHMTVQTAVLI 61
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL-----D 120
TLKA GA V ++ N STQD+ AA+AK GV V+A +GE+ EEY + + + D
Sbjct: 62 ETLKALGADVRWSSCNIFSTQDNAAAAIAKAGVPVFAWKGETDEEYEWCIAQTVKGFSGD 121
Query: 121 IRPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVND 180
PN+I+DDG D+ +LV EL+ +I+G SEETTTGV L L I VND
Sbjct: 122 GLPNMILDDGGDLTNLVIDHHPELVPKIFGISEETTTGVKNLYKRLSKGNLPMCAINVND 181
Query: 181 SYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVV 240
S K FDN YG +S DG+ RAT++++AGK V GYG G+G A R GA V+V
Sbjct: 182 SVTKSKFDNLYGCRESLVDGMKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVT 241
Query: 241 EVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHF 300
EVDPI AL+A M+G+ V +++ IFVT TGN I EHF M+D AI+ N GHF
Sbjct: 242 EVDPINALQASMEGYQVALVEDVMADAHIFVTTTGNDDIITSEHFPHMRDDAIVCNIGHF 301
Query: 301 DVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSF 360
D EI LE A E +P V Y +++GR + LLA GRLVNL A GHP+ +M SF
Sbjct: 302 DTEIQVGWLEANAKEHVEIKPQVDRYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSF 361
Query: 361 ALQAKAAEYIKENHERLE-PR-----VYVLPREIDEMVARIKLQSMGINIEELTEEQKKY 414
Q A + N + + PR V+ LP+ +DE VA + L +G + +LT +Q +Y
Sbjct: 362 TNQVLAQIELWSNRDNGKYPRGDKAGVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEY 421
Query: 415 L 415
+
Sbjct: 422 I 422
>sp|P10819|SAHH_DICDI ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|84087|pir||A27655 adenosylhomocysteinase
(EC 3.3.1.1) - slime mold (Dictyostelium discoideum)
>gi|167664|gb|AAA33165.1| (M19937)
S-adenosyl-L-homocysteine hydrolase [Dictyostelium
discoideum]
Length = 430
Score = 312 bits (791), Expect = 5e-84
Identities = 180/411 (43%), Positives = 250/411 (60%), Gaps = 4/411 (0%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y VKDISLA G K+I+ + MP L +R+++ + KG RIA LH+ ++TA L+ T
Sbjct: 6 YKVKDISLAAWGRKEIEIAANEMPGLMTLRKKYGPAQILKGARIAGCLHMTIQTAVLIET 65
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L A GA+V ++ N STQD AA+A GV VYA +GE++EEY + + + + N
Sbjct: 66 LTALGAQVQWSSCNIFSTQDQAAAAIAATGVPVYAWKGETEEEYNWCVEQTIVFQDGPLN 125
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
+I+DDG D+ +LVH + + L I G SEETT GV L M ++ L+ P I VNDS K
Sbjct: 126 MILDDGGDLTTLVHEKYPQFLAGIKGISEETTHGVHNLYKMFKEGKLKVPAINVNDSVTK 185
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++++AGK VV GYG G+G A +GA V+V E+DP
Sbjct: 186 SKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDP 245
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
I AL+A MDG+ +++M+ AA + +IFVT TG +R EHF +MK+ AI+ N GHFD EI
Sbjct: 246 INALQACMDGYQIVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEI 305
Query: 305 WKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQA 364
L A + +P V Y L +G + LLA+GRLVNL GHP+ +M SF Q
Sbjct: 306 DVAWLNANAKK-DTVKPQVDRYTLANGVHIILLAEGRLVNLGCGTGHPSFVMSNSFCNQT 364
Query: 365 KAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + E V++LP+ +DE VAR+ L +G + LTE+Q +YL
Sbjct: 365 LAQIALWTKTEEYPLGVHLLPKILDEEVARLHLDQLGAKLTTLTEKQSEYL 415
>pir||A45569 adenosylhomocysteinase (EC 3.3.1.1) - Leishmania donovani
Length = 437
Score = 311 bits (788), Expect = 1e-83
Identities = 185/421 (43%), Positives = 248/421 (57%), Gaps = 11/421 (2%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+DY VKDISLA G K I+ MP L +RRE+ +P KG +IA LH+ ++TA L+
Sbjct: 2 ADYKVKDISLAEWGRKAIELAENEMPGLMELRREYGPSQPLKGAKIAGCLHMTVQTAVLI 61
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL-----D 120
TLKA GA V ++ N STQD+ AA+AK GV V+A +GE+ EEY + + + D
Sbjct: 62 ETLKALGADVRWSSCNIFSTQDNAAAAIAKAGVPVFAWKGETDEEYEWCIAQTVKGFSGD 121
Query: 121 IRPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVND 180
PN+I+DDG D+ +LV EL+ +I+G SEETTTGV L L I VND
Sbjct: 122 GLPNMILDDGGDLTNLVIDHHPELVPKIFGISEETTTGVKNLYKRLSKGNLPMCAINVND 181
Query: 181 SYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVV 240
S K FDN YG +S DG+ RAT++++AGK V GYG G+G A R GA V+V
Sbjct: 182 SVTKSKFDNLYGCRESLVDGMKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVT 241
Query: 241 EVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHF 300
EVDPI AL+A M+G+ V +++ IFVT TGN I EHF M+D AI+ N GHF
Sbjct: 242 EVDPINALQASMEGYQVALVEDVMADAHIFVTTTGNDDIITSEHFPHMRDDAIVCNIGHF 301
Query: 301 DVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSF 360
D EI LE A E +P V Y +++GR + LLA GRLVNL A GHP+ +M SF
Sbjct: 302 DTEIQVGWLEANAKEHVEIKPQVDFYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSF 361
Query: 361 ALQAKAAEYIKENHERLE-PR-----VYVLPREIDEMVARIKLQSMGINIEELTEEQKKY 414
Q A + N + + PR V+ LP+ +DE VA + L +G + +LT +Q +Y
Sbjct: 362 TNQVLAQIELWSNRDNGKYPRGDKAGVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEY 421
Query: 415 L 415
+
Sbjct: 422 I 422
>sp|O50562|SAHH_RHOSH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|2661177|gb|AAB88245.1| (U76671)
S-adenosyl L-homocystein hydrolase [Rhodobacter
sphaeroides]
Length = 463
Score = 306 bits (776), Expect = 3e-82
Identities = 186/449 (41%), Positives = 253/449 (55%), Gaps = 41/449 (9%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+D+ VKD+SLA G K++D MP L +R EF KP KG RIA +LH+ ++TA L+
Sbjct: 2 ADFIVKDLSLADFGRKELDIAETEMPGLMALREEFGASKPLKGARIAGSLHMTVQTAVLI 61
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP-- 123
TL A GA V A+ N STQD AA+A GV V+AI+GE+ E+Y+ + +K
Sbjct: 62 ETLVALGADVRWASCNIFSTQDHAAAAIAASGVPVFAIKGETLEDYWAYTDKIFQFADGT 121
Query: 124 -NIIIDDGADM--------------------------VSLVHTERKELL----------D 146
N+I+DDG D V L + RK + D
Sbjct: 122 CNMILDDGGDATLYILLGARVEAGETDLIAVPQSDEEVCLFNQIRKRMAETPGWFTKQRD 181
Query: 147 EIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATN 206
I G SEETTTGV RL + + +L FP I VNDS K FDN+YG +S DGI RAT+
Sbjct: 182 AIKGVSEETTTGVHRLYDLHKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATD 241
Query: 207 LLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKI 266
+++AGK VV GYG G+G A RG GA V V EVDPI AL+A MDGF V+ +++ +
Sbjct: 242 VMMAGKVAVVCGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVVLEDVVQD 301
Query: 267 GDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEY 326
DIF+T TGN IR EH MKD AI+ N GHFD EI L+ + +N + V
Sbjct: 302 ADIFITTTGNRDVIRIEHMREMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKDQVDMI 359
Query: 327 KLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEPRVYVLPR 386
++ G R+ LL++GRL+NL A GHP+ +M SF Q A + +P VY+LP+
Sbjct: 360 EMPSGSRIILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELWTKGADYQPGVYILPK 419
Query: 387 EIDEMVARIKLQSMGINIEELTEEQKKYL 415
+DE VAR+ L+ +G+ + ++ EQ Y+
Sbjct: 420 ALDEKVARLHLKKIGVKLTDVRPEQADYI 448
>dbj|BAA34645.1| (AB020211) S-adenosyl L-homocystein hydrolase [Roseobacter
denitrificans]
Length = 462
Score = 305 bits (773), Expect = 6e-82
Identities = 182/448 (40%), Positives = 255/448 (56%), Gaps = 39/448 (8%)
Query: 5 TSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFL 64
T D+ VKDI+LA G K++D MP L +R E+ + KP G RI +LH+ ++TA L
Sbjct: 2 TKDFIVKDIALAEFGRKELDIAETEMPGLMALRAEYGDSKPLAGARIVGSLHMTIQTAVL 61
Query: 65 LLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIR-- 122
+ TL A GA V A+ N STQD AA+A G V+AI+G+S EE++++++++
Sbjct: 62 IETLVALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAIKGQSLEEHWDYLDRSFMFEDG 121
Query: 123 PNIIIDDGAD----------------MVSLVHTERKELL-------------------DE 147
PN+I+DDG D ++ + +E +E + D+
Sbjct: 122 PNLILDDGGDATLYVLLGARAEAGEEIIPVPTSEEEEAIKAQIKKRMAASPGWFTKVRDQ 181
Query: 148 IWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATNL 207
I G SEETTTGV RL + + L FP I VNDS K FDN+YG +S DGI RAT+
Sbjct: 182 IKGVSEETTTGVHRLYDLVKQGQLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDT 241
Query: 208 LVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIG 267
++AGK VV+GYG G+G A RG GA V V EVDPI AL+A MDGF V+ +++
Sbjct: 242 MMAGKVAVVMGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVLLEDVVGSA 301
Query: 268 DIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEYK 327
DIF+T TGN IR EH MKD AI+ N GHFD EI L+ + +N + V +
Sbjct: 302 DIFITTTGNKDVIRIEHMRAMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKEQVDMIE 359
Query: 328 LKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEPRVYVLPRE 387
+ +G RL LL++GRL+NL A GHP+ +M SF Q A + + + VY+LP+
Sbjct: 360 MPNGNRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELWTRADAYDNEVYILPKH 419
Query: 388 IDEMVARIKLQSMGINIEELTEEQKKYL 415
+DE VAR+ L +G+ + L EQ Y+
Sbjct: 420 LDEKVARLHLDRIGVKLTPLDPEQAAYI 447
>sp|P27604|SAHH_CAEEL ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7494525|pir||T41749
adenosylhomocysteinase (EC 3.3.1.1) - Caenorhabditis
elegans >gi|7505160|pir||T32918 adenosylhomocysteinase
(EC 3.3.1.1) - Caenorhabditis elegans
>gi|156326|gb|AAA28062.1| (M64306)
S-adenosylhomocysteine hydrolase [Caenorhabditis
elegans] >gi|298816|gb|AAB25906.1| (S57284)
S-adenosylhomocysteine hydrolase, AHH [Caenorhabditis
elegans, Peptide, 437 aa] >gi|2804454|gb|AAB97565.1|
(AF043699) C. elegans adenosylhomocysteinase (SW:P27604)
[Caenorhabditis elegans]
Length = 437
Score = 305 bits (773), Expect = 6e-82
Identities = 180/415 (43%), Positives = 248/415 (59%), Gaps = 7/415 (1%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K+I MP L +R ++ +P KG RIA LH+ ++TA L+ T
Sbjct: 8 YKVADIKLADFGRKEIILAENEMPGLMAMRSKYGPSQPLKGARIAGCLHMTIQTAVLIET 67
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIRP- 123
L A GA+V ++ N STQD AA+A+ GV VYA +GE+ EEY + + + D +P
Sbjct: 68 LTALGAEVQWSSCNIFSTQDHAAAAIAQTGVPVYAWKGETDEEYEWCIEQTIVFKDGQPL 127
Query: 124 NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYM 183
N+I+DDG D+ +LVH + + L I G SEETTTGV L M L+ P I VNDS
Sbjct: 128 NMILDDGGDLTNLVHAKYPQYLAGIRGLSEETTTGVHNLAKMLAKGDLKVPAINVNDSVT 187
Query: 184 KYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVD 243
K FDN YG +S DGI RAT++++AGK VV GYG G+G A + G+ VIV E+D
Sbjct: 188 KSKFDNLYGIRESLPDGIKRATDVMLAGKVAVVAGYGDVGKGSAASLKAFGSRVIVTEID 247
Query: 244 PIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVE 303
PI AL+A M+G+ V +++EAA +I VT TG + +HFEL+ + AI+ N GHFD E
Sbjct: 248 PINALQAAMEGYEVTTLEEAAPKANIIVTTTGCKDIVTGKHFELLPNDAIVCNVGHFDCE 307
Query: 304 IWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ 363
I L A + +P V Y LK+GR + LLA+GRLVNL A GHP+ +M SF Q
Sbjct: 308 IDVKWLNTNATKKDTIKPQVDRYTLKNGRHVILLAEGRLVNLGCATGHPSFVMSNSFTNQ 367
Query: 364 AKAAEYIKENH---ERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A + + + +YVLP+ +DE VA + L +G+ + +L++EQ YL
Sbjct: 368 VLAQVELWTKFGTPQEYKLGLYVLPKTLDEEVAYLHLAQLGVKLTKLSDEQASYL 422
>sp|P28183|SAHH_RHOCA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|151884|gb|AAA26094.1| (M80630)
adenosylhomocysteine hydrolase [Rhodobacter capsulatus]
Length = 463
Score = 303 bits (769), Expect = 2e-81
Identities = 184/449 (40%), Positives = 251/449 (54%), Gaps = 41/449 (9%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+DY VKDI LA G K++D MP L R EF +P KG RIA +LH+ ++TA L+
Sbjct: 2 ADYIVKDIKLAEFGRKELDIAETEMPGLMACREEFGPSQPLKGARIAGSLHMTIQTAVLI 61
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP-- 123
TLKA GA V A+ N STQD AA+A G V+A++GE+ EEY+ + +K
Sbjct: 62 ETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAVKGETLEEYWAYTDKIFQFPEGT 121
Query: 124 -NIIIDDGADM--------------------------VSLVHTERKELLDE--------- 147
N+I+DDG D V L + +K +++
Sbjct: 122 CNMILDDGGDATLYILLGARVEAGETDLIATPTSEDEVCLFNQIKKRMVESPGWFTQQRA 181
Query: 148 -IWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATN 206
I G SEETTTGV RL + + +L FP I VNDS K FDN+YG +S DGI RAT+
Sbjct: 182 AIKGVSEETTTGVHRLYDLHKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATD 241
Query: 207 LLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKI 266
+++AGK VV GYG G+G A RG GA V V EVDPI AL+A MDGF V+ +++
Sbjct: 242 VMMAGKVAVVCGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVVLEDVVAD 301
Query: 267 GDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEY 326
DIF+T TGN IR EH MKD AI+ N GHFD EI L+ + +N + V
Sbjct: 302 ADIFITTTGNKDVIRIEHMREMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKDQVDMI 359
Query: 327 KLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEPRVYVLPR 386
++ G R+ LL++GRL+NL A GHP+ +M SF Q A + +P VY+LP+
Sbjct: 360 EMPSGARIILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELWTKGAEYQPGVYILPK 419
Query: 387 EIDEMVARIKLQSMGINIEELTEEQKKYL 415
+DE VAR+ L+ +G+ + L +Q +Y+
Sbjct: 420 SLDEKVARLHLKKIGVKLTTLRPDQAEYI 448
>sp|P50251|SAHH_PYRFU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) (ADO-HCY) >gi|736277|emb|CAA56173.1|
(X79777) S-adenosyl-L-homocysteine hydrolase [Pyrococcus
furiosus]
Length = 169
Score = 298 bits (755), Expect = 8e-80
Identities = 146/166 (87%), Positives = 159/166 (94%)
Query: 2 VNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT 61
++C DYCVKD+SLA EG KKIDWVSRFMPVLQ+I+REFEEKKPFKGVRIAATLHLEMKT
Sbjct: 1 MDCGKDYCVKDLSLAEEGWKKIDWVSRFMPVLQYIKREFEEKKPFKGVRIAATLHLEMKT 60
Query: 62 AFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI 121
AFLLLTLKAGGA+VSAAASNPLSTQDDVVAALAK GVKVYAIRGES+E+YYEFM+KALDI
Sbjct: 61 AFLLLTLKAGGAEVSAAASNPLSTQDDVVAALAKAGVKVYAIRGESREQYYEFMHKALDI 120
Query: 122 RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMER 167
RPNIIIDDGADM+SLVH ER+E+LDEIWG SEETTTGVIRLRAME+
Sbjct: 121 RPNIIIDDGADMISLVHKERQEMLDEIWGGSEETTTGVIRLRAMEK 166
>pir||A46035 adenosylhomocysteinase (EC 3.3.1.1) - Rhodobacter capsulatus
Length = 462
Score = 296 bits (751), Expect = 2e-79
Identities = 183/449 (40%), Positives = 250/449 (54%), Gaps = 42/449 (9%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+DY VKDI LA G K++D MP L R EF +P KG RIA +LH+ ++TA L+
Sbjct: 2 ADYIVKDIKLAEFGRKELDIAETEMPGLMACREEFGPSQPLKGARIAGSLHMTIQTAVLI 61
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP-- 123
TLKA GA V A+ N STQD AA+A G V+A++GE+ EEY+ + +K
Sbjct: 62 ETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAVKGETLEEYWAYTDKIFQFPEGT 121
Query: 124 -NIIIDDGADM--------------------------VSLVHTERKELLDE--------- 147
N+I+DDG D V L + +K +++
Sbjct: 122 CNMILDDGGDATLYILLGARVEAGETDLIATPTSEDEVCLFNQIKKRMVESPGWFTQQRA 181
Query: 148 -IWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATN 206
I G SEETTTGV RL + + +L FP I VNDS K FDN+YG +S DGI RAT+
Sbjct: 182 AIKGVSEETTTGVHRLYDLHKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATD 241
Query: 207 LLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKI 266
+++AGK VV GYG G+G A RG GA V V EVDPI AL+A MDGF V+ +++
Sbjct: 242 VMMAGKVAVVCGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVVLEDVV-A 300
Query: 267 GDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEY 326
IF+T TGN IR EH MKD AI+ N GHFD EI L+ + +N + V
Sbjct: 301 DAIFITTTGNKDVIRIEHMREMKDMAIVGNIGHFDNEIQVAALKN--HKWTNIKDQVDMI 358
Query: 327 KLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEPRVYVLPR 386
++ G R+ LL++GRL+NL A GHP+ +M SF Q A + +P VY+LP+
Sbjct: 359 EMPSGARIILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELWTKGAEYQPGVYILPK 418
Query: 387 EIDEMVARIKLQSMGINIEELTEEQKKYL 415
+DE VAR+ L+ +G+ + L +Q +Y+
Sbjct: 419 SLDEKVARLHLKKIGVKLTTLRPDQAEYI 447
>emb|CAB88907.1| (AL353862) adenosylhomocysteinase [Streptomyces coelicolor A3(2)]
Length = 485
Score = 292 bits (740), Expect = 4e-78
Identities = 186/467 (39%), Positives = 246/467 (51%), Gaps = 53/467 (11%)
Query: 2 VNCTSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKT 61
V+ D+ V D+SLA G K+I MP L IR+E+ E +P G R+ +LH+ ++T
Sbjct: 4 VDNRQDFKVADLSLAAFGRKEITLAEHEMPGLMAIRKEYAEAQPLAGARVTGSLHMTVQT 63
Query: 62 AFLLLTLKAGGAKVSAAASNPLSTQDDVVAALA---------KEGVKVYAIRGESKEEYY 112
A L+ TL A GA+V A+ N STQD AA+A +GV V+A +GE+ EEY+
Sbjct: 64 AVLIETLVALGAEVRWASCNIFSTQDHAAAAIAVGPNGTPDNPQGVPVFAWKGETLEEYW 123
Query: 113 EFMNKALDIR------PNIIIDDGADMVSLVHT--------------------------- 139
+AL PN+I+DDG D LVH
Sbjct: 124 WCTEQALTWPNTPTGGPNMILDDGGDATLLVHKGVEYEKDGKVPSVDTAESDEHRVILEL 183
Query: 140 ----------ERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDN 189
+ +L EI G +EETTTGV RL M RD L FP I VND+ K FDN
Sbjct: 184 LTRTVGESPQKWTQLASEIRGVTEETTTGVHRLYEMHRDGTLLFPAINVNDAVTKSKFDN 243
Query: 190 RYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALE 249
+YG S DGI RAT++L+ GK VV GYG G+G A RG GA VI+ E+DPI AL+
Sbjct: 244 KYGCRHSLIDGINRATDVLIGGKTAVVCGYGDVGKGCAESLRGQGARVIITEIDPICALQ 303
Query: 250 ARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDL 309
A MDGF V ++ E DIFVT TGN I + MK AI+ N GHFD EI L
Sbjct: 304 AAMDGFQVTTLDEVVDKADIFVTTTGNKDIIMAKDMAKMKHQAIVGNIGHFDNEIDMAGL 363
Query: 310 EEL-AVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAE 368
+ + +P V + DG+ L +L++GRL+NL A GHP+ +M SFA Q A
Sbjct: 364 AQTPGIVKDEVKPQVHTWTYPDGKVLIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQI 423
Query: 369 YIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
+ + VYVLP+ +DE VAR+ L S+G+ + L EQ Y+
Sbjct: 424 ELFTKPDEYPTDVYVLPKHLDEKVARLHLDSLGVKLTTLRPEQADYI 470
>pir||D82730 adenosylhomocysteinase XF1037 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9105979|gb|AAF83847.1|AE003941_1
(AE003941) adenosylhomocysteinase [Xylella fastidiosa]
Length = 446
Score = 289 bits (733), Expect = 3e-77
Identities = 180/431 (41%), Positives = 239/431 (54%), Gaps = 45/431 (10%)
Query: 30 MPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAAASNPLSTQDDV 89
MP L IRR++ K+P KGVR+ +LH+ ++TA L+ TLK GA V A+ N STQD
Sbjct: 1 MPGLMSIRRKYASKQPLKGVRVTGSLHMTIQTAVLIETLKDIGADVRWASCNIFSTQDHA 60
Query: 90 VAALAKEGVKVYAIRGESKEEYYEFMNKALDIR--------PNIIIDDGADMVSLVHT-- 139
AA+A G V+A +GE+ EEY++ +AL P +I+DDG D L+H
Sbjct: 61 AAAIATSGTPVFAWKGETLEEYWDCTLQALTFTLSDGTLTGPELIVDDGGDATLLIHKGY 120
Query: 140 ----------ERKELLDE----------------IW--------GASEETTTGVIRLRAM 165
E + L+E W G SEETTTGV RL +
Sbjct: 121 ELENGSTWVDEPSDSLEEQVIKRLLKRIAIERPGYWTRVVNDWKGVSEETTTGVHRLYQI 180
Query: 166 ERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRG 225
L P I VNDS K FDN YG +S DG+ RA ++++AGK VV GYG G+G
Sbjct: 181 AATGRLLVPAINVNDSVTKSKFDNLYGCRESLADGLKRAMDVMLAGKLAVVCGYGDVGKG 240
Query: 226 IAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHF 285
A R GA VIV E+DPI AL+A M+GF V ++++ DI+VT TGN IR EH
Sbjct: 241 SAHSLRAYGARVIVTEIDPICALQAAMEGFEVTTVEDTLGQADIYVTTTGNKDVIRIEHM 300
Query: 286 ELMKDGAIMANAGHFDVEIWKPDLEELA-VEISNPRPNVTEYKLKDGRRLYLLADGRLVN 344
MKD I+ N GHFD EI L LA V+ N +P V ++ L +G L+LLA+GRLVN
Sbjct: 301 TAMKDQVIVCNIGHFDNEIQVDALNALAGVQKINIKPQVDKFILPNGNTLFLLAEGRLVN 360
Query: 345 LVAADGHPAEIMDMSFALQAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINI 404
L A GHP+ +M SFA Q A + +N + E VY LP+++DE VAR+ L+ +G+ +
Sbjct: 361 LGCATGHPSFVMSNSFANQTLAQIDLWQNKDVYEKNVYRLPKKLDEEVARLHLEKIGVKL 420
Query: 405 EELTEEQKKYL 415
LT Q YL
Sbjct: 421 TTLTANQAAYL 431
>sp|O08364|SAHH_MYCTU ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435511|pir||B70593
adenosylhomocysteinase (EC 3.3.1.1) - Mycobacterium
tuberculosis (strain H37RV) >gi|2072715|emb|CAB08349.1|
(Z95121) sahH [Mycobacterium tuberculosis]
>gi|8101960|gb|AAF72670.1| (AF262755)
S-adenosyl-L-homocysteine hydrolase [Mycobacterium
bovis]
Length = 495
Score = 289 bits (733), Expect = 3e-77
Identities = 181/461 (39%), Positives = 254/461 (54%), Gaps = 52/461 (11%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
D+ + D+SLA G K++ MP L +RRE+ E +P KG RI+ +LH+ ++TA L+
Sbjct: 20 DFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIE 79
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALA---------KEGVKVYAIRGESKEEYYEFMNK 117
TL A GA+V A+ N STQD AA+ +GV V+A +GE+ EEY+ +
Sbjct: 80 TLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQ 139
Query: 118 AL-----DIRPNIIIDDGADMVSLV----------------------------------H 138
L D N+I+DDG D LV
Sbjct: 140 MLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFE 199
Query: 139 TERKE---LLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQ 195
T++ + + + + G +EETTTGV+RL L FP I VNDS K FDN+YGT
Sbjct: 200 TDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRH 259
Query: 196 STWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGF 255
S DGI R T+ L+ GK V++ GYG G+G A +G GA V V E+DPI AL+A M+GF
Sbjct: 260 SLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGF 319
Query: 256 LVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVE 315
V++++EA DI VTATGN I EH + MKD AI+ N GHFD EI LE
Sbjct: 320 DVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGAT 379
Query: 316 ISNPRPNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENH 374
N +P V + D GR + +L++GRL+NL A GHP+ +M SFA Q A + +
Sbjct: 380 RVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKN 439
Query: 375 ERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
+ + VY LP+ +DE VARI ++++G ++ +LT+EQ +YL
Sbjct: 440 DEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYL 480
>sp|Q12663|SAHH_PNECA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|1401142|gb|AAC98514.1| (U57795)
S-adenosylhomocysteine hydrolase [Pneumocystis carinii
f. sp. ratti]
Length = 440
Score = 284 bits (720), Expect = 1e-75
Identities = 180/424 (42%), Positives = 241/424 (56%), Gaps = 25/424 (5%)
Query: 15 LAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAK 74
LA G K+I+ MP L RR K P + V+IA LH+ ++TA L+ TL GA+
Sbjct: 6 LAEWGRKEIELAENEMPGLISCRRNMRFK-PLR-VQIAGCLHMTIQTAVLIETLVELGAE 63
Query: 75 VSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI-----RPNIIIDD 129
V+ ++ N STQD AA+A G+ V+A +GE++EEY + L N+I+DD
Sbjct: 64 VTWSSCNIFSTQDHAAAAIAASGISVFAWKGETEEEYLWCIETQLTSFKDGKHLNMILDD 123
Query: 130 GADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDN 189
G D+ SLVH + + L G SEETTTGV + M ++ L+ P I VNDS K FDN
Sbjct: 124 GGDVTSLVHNKYPDYLKNCKGISEETTTGVHQFYKMLKEGKLKVPAINVNDSVTKSKFDN 183
Query: 190 RYGTG----------------QSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGL 233
YG +S DGI RAT++++A K +V G+G G+G A RG+
Sbjct: 184 LYGVSLVLIYKIISNIKLRCRESLIDGIKRATDIMIAAKVAIVAGFGDVGKGCAKALRGM 243
Query: 234 GATVIVVEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAI 293
GA VI+ E+DPI AL+A M+G+ V M+E A DIFVTATG I HFE MK+ AI
Sbjct: 244 GARVIITEIDPIVALQASMEGYQVAVMEEVADQADIFVTATGCKDIICERHFEAMKNDAI 303
Query: 294 MANAGHFDVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPA 353
+ N GHFDVEI L + ISN +P V Y L +GR + LLA+GRLVNL A GH +
Sbjct: 304 ICNIGHFDVEIDVAWLIKKCSSISNIKPQVDRYLLGNGRNIILLAEGRLVNLGCATGHSS 363
Query: 354 EIMDMSFALQAKAAEYIKENHERLEP-RVYVLPREIDEMVARIKLQSMGINIEELTEEQK 412
+M MSF Q A + E P V+ LP+++DE VAR+ L +G + LT EQ
Sbjct: 364 MVMSMSFTNQVLAQIALWTAQEGQYPLGVHFLPKKLDEEVARLHLSKLG-KLTSLTPEQS 422
Query: 413 KYLE 416
YL+
Sbjct: 423 AYLD 426
>sp|P50250|SAHH_PLAF7 ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|627050|pir||A54040
adenosylhomocysteinase (EC 3.3.1.1) - malaria parasite
(Plasmodium falciparum) >gi|460639|gb|AAA21391.1|
(U07365) S-adenosylhomocysteine hydrolase [Plasmodium
falciparum]
Length = 479
Score = 282 bits (713), Expect = 7e-75
Identities = 172/457 (37%), Positives = 250/457 (54%), Gaps = 51/457 (11%)
Query: 10 VKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLK 69
VKDISLAP G +++ MP L IR E+ + +P K +I LH+ ++ A L+ TL+
Sbjct: 8 VKDISLAPFGKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCLHMTVECALLIETLQ 67
Query: 70 AGGAKVSAAASNPLSTQDDVVAALAK-EGVKVYAIRGESKEEYYEFMNKAL------DIR 122
GA++ + N ST D AA++ E V V+A + E+ EEY+ + AL D
Sbjct: 68 KLGAQIRWCSCNIYSTADYAAAAVSTLENVTVFAWKNETLEEYWWCVESALTWGDGDDNG 127
Query: 123 PNIIIDDGADMVSLVHT--------ERKELLDE--------------------------- 147
P++I+DDG D LVH E K +L +
Sbjct: 128 PDMIVDDGGDATLLVHKGVEYEKLYEEKNILPDPEKAKNEEERCFLTLLKNSILKNPKKW 187
Query: 148 ------IWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
I G SEETTTGV+RL+ M++ L F I VND+ K +DN YG S DG+
Sbjct: 188 TNIAKKIIGVSEETTTGVLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCRHSYTDGL 247
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT+ L++GK VV+ GYG G+G A +GLGA V + E+DPI A++A M+GF V+++
Sbjct: 248 MRATDFLISGKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEGFNVVTLD 307
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDL-EELAVEISNPR 320
E GD F+T TGN+ I+ EH MK+ A++ N GHFD EI +L + I N +
Sbjct: 308 EIVDKGDFFITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVNELFNYKGIHIENVK 367
Query: 321 PNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHE--RLE 378
P V L +G ++ +LA GRL+NL A GHPA +M SF Q A + +N + + E
Sbjct: 368 PQVDRITLPNGNKIIVLARGRLLNLGCATGHPAFVMSFSFCNQTFAQLDLWQNKDTNKYE 427
Query: 379 PRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
+VY+LP+ +DE VA L+ + ++ EL + Q ++L
Sbjct: 428 NKVYLLPKHLDEKVALYHLKKLNASLTELDDNQCQFL 464
>gb|AAD56048.1|AF185635_1 (AF185635) S-adenosyl-L-homocysteinase [Lupinus luteus]
Length = 485
Score = 279 bits (706), Expect = 4e-74
Identities = 172/458 (37%), Positives = 250/458 (54%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L R EF +PFKG +I +LH+ ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLEIELAEVEMPGLMASRSEFGPSQPFKGAKITGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP--- 123
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGG 132
Query: 124 -NIIIDDGADMVSLVHTERK---------------------------------------- 142
++I+DDG D L+H K
Sbjct: 133 PDLIVDDGGDTTLLIHEGVKAEEIYEKSGQFPDPDSTDNAEFKIVLSIIKEGLKTDPKRY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ D + G SEETTTGV RL M+ + L FP I VNDS K FDN YG S DG+
Sbjct: 193 HKMKDRVVGVSEETTTGVKRLYQMQANGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK VV GYG G+G A + GA VIV E+DPI AL+A M+G V++++
Sbjct: 253 MRATDVMIAGKVAVVAGYGDVGKGCAAALKQAGARVIVTEIDPICALQATMEGLQVLTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLE-ELAVEISNPR 320
+ DIFVT TGN I +H + MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEADIFVTTTGNKDIIMLDHMKKMKNNAIVCNIGHFDNEIDMLGLETHPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + + + +LA+GRL+NL A GHP+ +M SF Q A+ + +++ +
Sbjct: 373 PQTDRWVFPETNTGIIILAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L+ +G + +L+++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLEKLGAKLTKLSKDQADYI 470
>sp|Q01781|SAHH_PETCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|169663|gb|AAA33856.1| (M81885)
S-adenosylhomocysteine hydrolase [Petroselinum crispum]
Length = 485
Score = 277 bits (702), Expect = 1e-73
Identities = 172/458 (37%), Positives = 248/458 (53%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+SLA G +++ MP L R EF +PFKG RI +LH+ ++T L+
Sbjct: 13 EYKVKDMSLADFGRLELELAEVEMPGLMSCRTEFGPSQPFKGARITGSLHMTIQTGVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPN-- 124
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P+
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSCAVFAWKGETLQEYWWCTERALDWGPDGG 132
Query: 125 --IIIDDGADMVSLVHTERK---------------------------------------- 142
+I+DDG D L+H K
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEYKKSGAIPDPASTDNAEFQIVLSIIRDGLKSDPMKY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ D + G SEETTTGV RL M+++ L FP I VNDS K FDN YG S DG+
Sbjct: 193 HKMKDRLVGVSEETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK ++ GYG G+G A + GA VIV E+DPI AL+A M+G V+ ++
Sbjct: 253 MRATDVMIAGKVALIAGYGDVGKGCAAAMKQAGARVIVTEIDPICALQATMEGLQVLPLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEVDIFVTTTGNKDIIMVSDMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + D GR + +LA+GRL+NL A GHP+ +M SF Q A+ + +++ +
Sbjct: 373 PQTDRWVFPDTGRGIIILAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +L+++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKLGAKLTKLSKDQADYI 470
>sp|P35007|SAHH_CATRO ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|481237|pir||S38379
adenosylhomocysteinase (EC 3.3.1.1) - Madagascar
periwinkle >gi|407412|emb|CAA81527.1| (Z26881)
S-adenosyl-L-homocysteine hydrolase [Catharanthus
roseus]
Length = 485
Score = 277 bits (701), Expect = 2e-73
Identities = 172/458 (37%), Positives = 246/458 (53%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L R EF +PFKG +I +LH+ ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLEIELAEVEMPGLMSCRAEFGPSQPFKGAKITGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRPN-- 124
TL A GA+V + N STQ+ AA+A++ V+A +GE+ +EY+ +ALD P+
Sbjct: 73 TLTALGAEVRWCSCNIFSTQEHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPDGG 132
Query: 125 --IIIDDGADMVSLVH-----------------------------------------TER 141
+I+DDG D L+H T+
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEYKKNGALPDPSSTDNAEFQIVLTIIRDGLKSDPTKY 192
Query: 142 KELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
+ + + G SEETTTGV RL M+ + L FP I VNDS K FDN YG S DG+
Sbjct: 193 TRMKERLVGVSEETTTGVKRLYQMQANGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK VV GYG G+G A + GA VIV E+DPI AL+A M+G V++++
Sbjct: 253 MRATDVMIAGKVAVVAGYGDVGKGCAAALKQAGARVIVTEIDPICALQATMEGLQVLTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEADIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + D + +LA+GRL+NL A GHP+ +M SF Q A+ + + +
Sbjct: 373 PQTDRWVFPDTNSGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNERKTGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +LT++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKLGAKLTKLTKDQADYI 470
>sp|P51540|SAHH_TRIVA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|1118009|gb|AAC47319.1| (U40872)
S-adenosyl-L-homocysteine hydrolase [Trichomonas
vaginalis]
Length = 486
Score = 275 bits (696), Expect = 6e-73
Identities = 175/460 (38%), Positives = 247/460 (53%), Gaps = 51/460 (11%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y + DI+L G K++ + MP L +R + KP KGVRI+ +LH+ ++TA L+
Sbjct: 12 EYRIADINLHVLGRKELTLAEKEMPGLMVLRERYSASKPLKGVRISGSLHMTVQTAVLIE 71
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALA---------KEGVKVYAIRGESKEEYYEFMNK 117
TL A GA V A+ N STQD AA+ G+ V+A +GE+ EY+E +
Sbjct: 72 TLTALGADVRWASCNIFSTQDTAAAAIVVGPTGTPEKPAGIPVFAWKGETLPEYWENTYR 131
Query: 118 ALDIR----PNIIIDDGADMVSLVH--------------TERKEL--------LDEIW-- 149
AL P ++DDG D L+ TE L L +++
Sbjct: 132 ALTWPDGQGPQQVVDDGGDATLLISKGFEFETAGAVPEPTEADNLEYRCVLATLKQVFNQ 191
Query: 150 -------------GASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQS 196
G SEETTTGV RL +E++ L FP I VND+ K FDN YG S
Sbjct: 192 DKNHWHTVAAGMNGVSEETTTGVHRLYQLEKEGKLLFPAINVNDAVTKSKFDNIYGCRHS 251
Query: 197 TWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFL 256
DGI RA+++++ GK +V+GYG G+G A RG GA VI+ EVDPI AL+A M+G+
Sbjct: 252 LIDGINRASDVMIGGKTALVMGYGDVGKGCAQSLRGQGARVIITEVDPICALQAVMEGYQ 311
Query: 257 VMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVE 315
V ++E K DIFVT TGN I + MKD AI+ N GHFD EI L + ++
Sbjct: 312 VRRIEEVVKDVDIFVTCTGNCDIISVDMMAQMKDKAIVGNIGHFDNEIDTDGLMKYPGIK 371
Query: 316 ISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHE 375
+P ++ DG + LLA+GRL+NL A GHP+ +M MSF Q A + E
Sbjct: 372 HIPIKPEYDMWEFPDGHAILLLAEGRLLNLGCATGHPSFVMSMSFTNQTLAQLDLYEKRG 431
Query: 376 RLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
LE +VY LP+ +DE V R+ L S+ +++ +LT++Q Y+
Sbjct: 432 NLEMKVYTLPKHLDEEVVRLHLGSLDVHLTKLTQKQADYI 471
>sp|O23255|SAHH_ARATH ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435510|pir||C71400
adenosylhomocysteinase (EC 3.3.1.1) [similarity] -
Arabidopsis thaliana >gi|2244750|emb|CAB10173.1|
(Z97335) adenosylhomocysteinase [Arabidopsis thaliana]
>gi|3088579|gb|AAC14714.1| (AF059581)
S-adenosyl-L-homocysteine hydrolase [Arabidopsis
thaliana] >gi|7268098|emb|CAB78436.1| (AL161537)
adenosylhomocysteinase [Arabidopsis thaliana]
Length = 485
Score = 274 bits (694), Expect = 1e-72
Identities = 170/458 (37%), Positives = 249/458 (54%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +++ MP L R EF +PFKG RI +LH+ ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLELELAEVEMPGLMACRTEFGPSQPFKGARITGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP--- 123
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGG 132
Query: 124 -NIIIDDGADMVSLVHTERK---------------------------------------- 142
++I+DDG D L+H K
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEIFEKTGQVPDPTSTDNPEFQIVLSIIKEGLQVDPKKY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ + + G SEETTTGV RL M+++ L FP I VNDS K FDN YG S DG+
Sbjct: 193 HKMKERLVGVSEETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK V+ GYG G+G A + GA VIV E+DPI AL+A M+G V++++
Sbjct: 253 MRATDVMIAGKVAVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGLQVLTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEADIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIK 372
Query: 321 PNVTEYKLKDGRR-LYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + + + + +LA+GRL+NL A GHP+ +M SF Q A+ + ++ +
Sbjct: 373 PQTDRWVFPETKAGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKASGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +L+++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVALLHLGKLGARLTKLSKDQSDYV 470
>sp|P50248|SAHH_TOBAC ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) (CYTOKININ BINDING PROTEIN CBP57)
>gi|441217|dbj|BAA03709.1| (D16138)
S-adenosyl-L-homocystein hydrolase [Nicotiana
sylvestris] >gi|1857024|dbj|BAA08142.1| (D45204)
S-adenosyl-L-homocysteine hydrolase [Nicotiana tabacum]
>gi|2588781|dbj|BAA23164.1| (D49804)
S-adenosyl-L-homocysteine hydrolase [Nicotiana tabacum]
Length = 485
Score = 274 bits (694), Expect = 1e-72
Identities = 171/458 (37%), Positives = 248/458 (53%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L R EF +PFKG +I +LH+ ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLEIELAEVEMPGLMACRTEFGPSQPFKGAKITGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP--- 123
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGG 132
Query: 124 -NIIIDDGADMVSLVHTERK---------------------------------------- 142
++I+DDG D L+H K
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEFAKNGTIPDPNSTDNAEFQLVLTIIKESLKTDPLKY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ + + G SEETTTGV RL M+ + L FP I VNDS K FDN YG S DG+
Sbjct: 193 TKMKERLVGVSEETTTGVKRLYQMQANGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK +V GYG G+G A + GA VIV E+DPI AL+A M+G V++++
Sbjct: 253 MRATDVMIAGKVALVAGYGDVGKGCAAALKQAGARVIVTEIDPICALQATMEGLQVLTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSDVDIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + D + +LA+GRL+NL A GHP+ +M SF Q A+ + +++ +
Sbjct: 373 PQTDRWVFPDTNSGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +L+++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKLGAKLTKLSKDQADYI 470
>sp|P32112|SAHH_WHEAT ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435519|pir||T06764
adenosylhomocysteinase (EC 3.3.1.1) - wheat
>gi|170773|gb|AAA34303.1| (L11872)
S-adenosyl-L-homocysteine hydrolase [Triticum aestivum]
Length = 485
Score = 273 bits (691), Expect = 3e-72
Identities = 168/458 (36%), Positives = 247/458 (53%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+ A G +++ MP L R EF +PFKG RI+ +LH+ ++TA L+
Sbjct: 13 EYKVKDLFQADFGRLELELAEVEMPGLMACRTEFGPSQPFKGARISGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIR---- 122
TL A GA+V + N S+QD AA+A++ V+A +GE+ EEY+ + LD
Sbjct: 73 TLTALGAEVRWCSCNIFSSQDHAAAAIARDSAAVFAWKGETLEEYWWCTERCLDWGVGGG 132
Query: 123 PNIIIDDGADMVSLVH-----------------------------------------TER 141
P++I+DDG D L+H ++
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEFEKSGKVPDPESTDNPEFKIVLTIIRDGLKTDASKY 192
Query: 142 KELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
+++ + + G SEETTTGV RL M+ L FP I VNDS K FDN YG S DG+
Sbjct: 193 RKMKERLVGVSEETTTGVKRLYQMQESGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK VV GYG G+G A + GA VIV E+DPI AL+A M+G +++++
Sbjct: 253 MRATDVMIAGKVAVVCGYGDVGKGCAAALKQAGARVIVTEIDPICALQALMEGIQILTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEADIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMNGLETYPGVKRITIK 372
Query: 321 PNVTEYKLKDGRR-LYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + + + + +LA+GRL+NL A GHP+ +M SF Q A+ + ++ +
Sbjct: 373 PQTDRWVFPETKTGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKASGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +LT+ Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKLGARLTKLTKSQSDYI 470
>sp|P93253|SAHH_MESCR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|1724102|gb|AAB38499.1| (U79766)
S-adenosyl-L-homocystein hydrolase; SAH
[Mesembryanthemum crystallinum]
Length = 485
Score = 272 bits (688), Expect = 6e-72
Identities = 170/458 (37%), Positives = 245/458 (53%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L R EF +PFKG +I +LH+ ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLEIELAEVEMPGLMACRTEFGPSQPFKGAKITGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIR---- 122
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGAGGG 132
Query: 123 PNIIIDDGADMVSLVHTERK---------------------------------------- 142
P++I+DDG D L+H K
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEYEKNGTIPDPTSTDNPEFQLVLGLIRDSLKVDPKRY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ + G SEETTTGV RL M+ L FP I VNDS K FDN YG S DG+
Sbjct: 193 HKMKTRLVGVSEETTTGVKRLYQMQATGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK VV GYG G+G A+ + GA VIV E+DPI AL+A M+GF +++++
Sbjct: 253 MRATDVMIAGKVGVVCGYGDVGKGCALALKAAGARVIVTEIDPICALQALMEGFQILTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEADIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLENYPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + + + +LA+GRL+ L A GHP+ +M SF Q A+ + + +
Sbjct: 373 PQTDRFVFPETNTGIIVLAEGRLMKLGCATGHPSFVMSCSFTNQVIAQLELWNERASGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +L+++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKLGAKLTKLSKDQADYI 470
>sp|P50246|SAHH_MEDSA ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|535584|gb|AAB41814.1| (L36119)
adenosylhomocysteinase [Medicago sativa]
Length = 485
Score = 271 bits (686), Expect = 1e-71
Identities = 172/458 (37%), Positives = 246/458 (53%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L R EF +PFKG RI +LH+ ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLEIELAEVEMPGLMSCRTEFGPSQPFKGARITGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP--- 123
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCSERALDWGPGGG 132
Query: 124 -NIIIDDGADMVSLVHTERK---------------------------------------- 142
++I+DDG D+ L+H K
Sbjct: 133 PDLIVDDGGDVTLLIHEGVKAEEVFEKTGQLPDPSSTDNAEMQIVLTIIRDGLKTDPKRY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ I G SEETTTGV RL M+ L FP I VNDS K FDN YG S DG+
Sbjct: 193 QKMKTRIVGVSEETTTGVKRLYQMQASGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK VV GYG G+G A + GA VIV E+DPI AL+A M+G V++++
Sbjct: 253 MRATDVMIAGKVAVVCGYGDVGKGCAAALKQGGARVIVTEIDPICALQALMEGLQVLTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I + MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVISEADIFVTTTGNKDIIMVSDMKKMKNNAIVCNIGHFDNEIDMHGLETYPGVKRITIK 372
Query: 321 PNVTEYKLKDGRR-LYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + + + + +LA+GRL+NL A GHP+ +M SF Q A+ + ++ +
Sbjct: 373 PQTDRWVFPETKSGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQIELWKEKTSGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +L+++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGQLGAKLTKLSKDQADYI 470
>sp|P50249|SAHH_PHASS ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|7435512|pir||S71621
adenosylhomocysteinase (EC 3.3.1.1) - Phalaenopsis sp
>gi|758247|emb|CAA56278.1| (X79905)
S-adenosylhomocysteine hydrolase [Phalaenopsis sp.]
Length = 485
Score = 270 bits (683), Expect = 2e-71
Identities = 174/458 (37%), Positives = 240/458 (51%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L R EF +PFKG RI+ +LH+ ++TA L+
Sbjct: 13 EYKVKDLSQADFGRLEIELAEVEMPGLMACRAEFGPSQPFKGARISGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIR---- 122
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ + L+
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERCLEWGAGGG 132
Query: 123 PNIIIDDGADMVSLVHT-----------------------------------------ER 141
P++I+DDG D L+H +
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEYEKNGKIPDPASTDNAEFQIVLGLIRDSLSVDPKKY 192
Query: 142 KELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
+ + + + G SEETTTGV RL M+ L FP I VNDS K FDN YG S DG+
Sbjct: 193 RRMKERLVGVSEETTTGVKRLYQMQYSGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK VV GYG G G A + GA VIV E+DPI AL+A M+G V+ ++
Sbjct: 253 MRATDVMIAGKVAVVCGYGDVGLGCAAALKTAGARVIVTEIDPICALQALMEGLPVLRLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEADIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLESFPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKA-AEYIKENHE-RL 377
P D + +LA+GRL+NL A GHP+ +M SF Q A E KE +
Sbjct: 373 PQTDRRVFPDTNSGILVLAEGRLMNLGCATGHPSFVMSSSFTNQVIAQLELWKERASGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +LT Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKLGAKLTKLTPSQADYI 470
>dbj|BAB01858.1| (AP000377) S-adenosyl L-homocystein hydrolase [Arabidopsis
thaliana]
Length = 485
Score = 270 bits (683), Expect = 2e-71
Identities = 170/458 (37%), Positives = 244/458 (53%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L EF +P KG RI +LH+ ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLEIELAEVEMPGLVSCVTEFGPSQPLKGARITGSLHMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP--- 123
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGG 132
Query: 124 -NIIIDDGADMVSLVHTERK---------------------------------------- 142
++I+DDG D L+H K
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEIFAKNGTFPDPTSTDNPEFQIVLSIIKDGLQVDPKKY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ + + G SEETTTGV RL M+ L FP I VNDS K FDN YG S DG+
Sbjct: 193 HKMKERLVGVSEETTTGVKRLYQMQETGALLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK V+ GYG G+G A + GA VIV E+DPI AL+A M+G V++++
Sbjct: 253 MRATDVMIAGKVAVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGLQVLTLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIF T TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEADIFCTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + D + +LA+GRL+NL A GHP+ +M SF Q A+ + +++ +
Sbjct: 373 PQTDRWVFPDTNSGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L +G + +LT++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKLGARLTKLTKDQSDYV 470
>dbj|BAA74851.1| (AB020635) KIAA0828 protein [Homo sapiens]
Length = 619
Score = 270 bits (683), Expect = 2e-71
Identities = 153/415 (36%), Positives = 239/415 (56%), Gaps = 5/415 (1%)
Query: 5 TSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFL 64
+SD+CVK+I A G ++I+ + MP L +R+ + +KP G +I H+ +TA L
Sbjct: 191 SSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVL 250
Query: 65 LLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI--- 121
+ TL A GA+ AA N ST ++V AALA+ G V+A +GES+++++ +++ +++
Sbjct: 251 METLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGW 310
Query: 122 RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDS 181
+PN+I+DDG D+ ++ + + +I G EE+ TGV RL + + L P + VNDS
Sbjct: 311 QPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDS 370
Query: 182 YMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 241
K FDN Y +S DG+ R T+++ GK VVV GYG G+G + +G+ V V E
Sbjct: 371 VTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTE 430
Query: 242 VDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFD 301
+DPI AL+A MDGF ++ + E + DI +T TGN + REH + MK+ I+ N GH +
Sbjct: 431 IDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSN 490
Query: 302 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 361
EI L + R V DG+R+ LLA+GRL+NL + P ++ ++
Sbjct: 491 TEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNL-SCSTVPTFVLSITAT 549
Query: 362 LQAKA-AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
QA A E R + VY+LP+++DE VA + L + ++ ELT+EQ KYL
Sbjct: 550 TQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYL 604
>gb|AAD50775.1|AF161705_1 (AF161705) S-adenosyl-l-homocysteine hydrolase [Lycopersicon
esculentum]
Length = 485
Score = 266 bits (673), Expect = 3e-70
Identities = 170/458 (37%), Positives = 243/458 (52%), Gaps = 49/458 (10%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +I+ MP L R EF +P KG +I +LH+ ++TAFL+
Sbjct: 13 EYKVKDMSQADFGRLEIELAEVEMPGLMASRAEFGPSQPVKGAKITCSLHMTIQTAFLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP--- 123
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGG 132
Query: 124 -NIIIDDGADMVSLVHTERK---------------------------------------- 142
++I+DDG D L+H K
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEFAKNGTVPDPTSTDNVEFQLVLTIIKESLKTDPLRY 192
Query: 143 -ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
++ + + G SEETTTGV +L M + L F I VNDS K FDN YG S DG+
Sbjct: 193 TKMKERLVGVSEETTTGVKKLYQMPANGSLLFLPINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK +V GYG G+G A + GA VIV E+DPI AL+A M+G V+ ++
Sbjct: 253 MRATDVMIAGKVALVAGYGDVGKGCAAAMKQAGARVIVTEIDPICALQATMEGLQVLFLE 312
Query: 262 EAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPR 320
+ DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +
Sbjct: 313 DVVSEVDIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMHGLETFPGVKRITIK 372
Query: 321 PNVTEYKLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERL 377
P + D + +LA+GRL+NL A GHP+ +M SF Q A+ + + + +
Sbjct: 373 PQTDRWVFPDTNSGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNERSSGKY 432
Query: 378 EPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
E +VYVLP+ +DE VA + L G + +LT++Q Y+
Sbjct: 433 EKKVYVLPKHLDEKVAALHLGKFGAKLTKLTKDQADYI 470
>sp|P50245|SAH2_DROME PUTATIVE ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE
HYDROLASE) (ADOHCYASE) >gi|969078|gb|AAA84400.1|
(U31961) S-adenosylhomocysteine hydrolase [Drosophila
melanogaster] >gi|7300202|gb|AAF55367.1| (AE003715)
Ahcy89E gene product [Drosophila melanogaster]
Length = 504
Score = 266 bits (672), Expect = 4e-70
Identities = 156/413 (37%), Positives = 233/413 (55%), Gaps = 4/413 (0%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+D+CVK IS + G ++I+ MP + +R+ +++KP KG I H+ ++A L+
Sbjct: 66 TDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQSAVLI 125
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIR 122
TL GA V AA N STQ+ V AALA+ G+ ++A RGE++EE++ +++A+ +
Sbjct: 126 ETLVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQ 185
Query: 123 PNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSY 182
PN+I+DDG D L+ + + I G EE+ TGV RL + + L P I VNDS
Sbjct: 186 PNLILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSV 245
Query: 183 MKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEV 242
K FD Y S D + R T+++ GK VV+ GYG G+G A +G G V V EV
Sbjct: 246 TKNKFDTFYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEV 305
Query: 243 DPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDV 302
DPI AL+A MDGF V+ + E + D+ VTATGN I R+H MK+G I+ N GH
Sbjct: 306 DPICALQAAMDGFRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCS 365
Query: 303 EIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFAL 362
EI L + R V + DGR + LLA+GRLVNL + + ++ ++ +
Sbjct: 366 EIDVNGLHTPELTWERVRSQVDHIRWPDGRMIILLAEGRLVNL-SCSTISSFVVSVASST 424
Query: 363 QAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
QA A + R + VY+LP+++DE VA + L + ++ ELT+EQ K++
Sbjct: 425 QALALIELFSAPGRYKSDVYLLPKKMDEYVASLHLATFDAHLTELTDEQSKFM 477
>emb|CAB09795.1| (Z97059) S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]
Length = 467
Score = 265 bits (669), Expect = 1e-69
Identities = 166/452 (36%), Positives = 243/452 (53%), Gaps = 49/452 (10%)
Query: 13 ISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGG 72
+S A G +++ MP L R EF +PFKG RI +LH+ ++TA L+ TL A G
Sbjct: 1 MSQADFGRLELELAEVEMPGLMACRTEFGPSQPFKGARITGSLHMTIQTAVLIETLTALG 60
Query: 73 AKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP----NIIID 128
A+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P ++I+D
Sbjct: 61 AQVRWCSCNIFSTQDHARAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVD 120
Query: 129 DGADMVSLVHTERK-----------------------------------------ELLDE 147
DG D L+H K ++ +
Sbjct: 121 DGGDATLLIHEGVKAEEIFEKTGQVPDPTSTDNPEFQIVLSIIKEGLQVDPKKYHKMKER 180
Query: 148 IWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATNL 207
+ G SEETTTGV RL M+++ L FP I VNDS K FDN YG S DG+MRAT++
Sbjct: 181 LVGVSEETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDV 240
Query: 208 LVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIG 267
++AGK V+ GYG G+G A + GA VIV E+DPI AL+A M+G V+++++
Sbjct: 241 MIAGKVAVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGLQVLTLEDVVSEA 300
Query: 268 DIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPRPNVTEY 326
DIFVT TGN I +H MK+ AI+ N GHFD EI LE V+ +P +
Sbjct: 301 DIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRW 360
Query: 327 KLKDGRR-LYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERLEPRVYV 383
+ + + +LA GRL+NL A GHP+ +M SF Q A+ + ++ + E +VYV
Sbjct: 361 VFPETKAGIIVLAQGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKASGKYEKKVYV 420
Query: 384 LPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
LP+ +DE VA + L +G + +L+++Q Y+
Sbjct: 421 LPKHLDEKVALLHLGKLGARLRKLSKDQSDYV 452
>gi|5729724 S-adenosylhomocysteine hydrolase-like 1; S-adenosyl homocysteine
hydrolase homolog [Homo sapiens]
>gi|11428175|ref|XP_002148.1| S-adenosylhomocysteine
hydrolase-like 1 [Homo sapiens]
>gi|6094223|sp|O43865|SAH2_HUMAN PUTATIVE
ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE
HYDROLASE) (ADOHCYASE) >gi|2852125|gb|AAC01960.1|
(U82761) S-adenosyl homocysteine hydrolase homolog [Homo
sapiens]
Length = 500
Score = 265 bits (669), Expect = 1e-69
Identities = 153/415 (36%), Positives = 239/415 (56%), Gaps = 5/415 (1%)
Query: 5 TSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFL 64
+S++CVK+I A G ++I+ + M L +R+ + +KP G +I H+ +TA L
Sbjct: 72 SSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVL 131
Query: 65 LLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI--- 121
+ TL A GA+ +A N STQ++V AALA+ GV V+A +GES+++++ +++ +++
Sbjct: 132 IETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGW 191
Query: 122 RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDS 181
+ N+I+DDG D+ V+ + + +I G EE+ TGV RL + + L P + VNDS
Sbjct: 192 QANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDS 251
Query: 182 YMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 241
K FDN Y +S DG+ R T+++ GK VVV GYG G+G + LGA V + E
Sbjct: 252 VTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITE 311
Query: 242 VDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFD 301
+DPI AL+A MDGF V+ + E + D+ +T TGN + REH + MK+ I+ N GH +
Sbjct: 312 IDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSN 371
Query: 302 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 361
EI L + R V DG+R+ LLA+GRL+NL + P ++ ++
Sbjct: 372 TEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNL-SCSTVPTFVLSITAT 430
Query: 362 LQAKA-AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
QA A E R + VY+LP+++DE VA + L S ++ ELT++Q KYL
Sbjct: 431 TQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYL 485
>pir||T08681 adenosylhomocysteinase (EC 3.3.1.1) DKFZp564A1523 - human
(fragment) >gi|4884204|emb|CAB43223.1| (AL049954)
hypothetical protein [Homo sapiens]
Length = 597
Score = 265 bits (669), Expect = 1e-69
Identities = 153/415 (36%), Positives = 239/415 (56%), Gaps = 5/415 (1%)
Query: 5 TSDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFL 64
+S++CVK+I A G ++I+ + M L +R+ + +KP G +I H+ +TA L
Sbjct: 169 SSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVL 228
Query: 65 LLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI--- 121
+ TL A GA+ +A N STQ++V AALA+ GV V+A +GES+++++ +++ +++
Sbjct: 229 IETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGW 288
Query: 122 RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDS 181
+ N+I+DDG D+ V+ + + +I G EE+ TGV RL + + L P + VNDS
Sbjct: 289 QANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDS 348
Query: 182 YMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVE 241
K FDN Y +S DG+ R T+++ GK VVV GYG G+G + LGA V + E
Sbjct: 349 VTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITE 408
Query: 242 VDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFD 301
+DPI AL+A MDGF V+ + E + D+ +T TGN + REH + MK+ I+ N GH +
Sbjct: 409 IDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSN 468
Query: 302 VEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFA 361
EI L + R V DG+R+ LLA+GRL+NL + P ++ ++
Sbjct: 469 TEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNL-SCSTVPTFVLSITAT 527
Query: 362 LQAKA-AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
QA A E R + VY+LP+++DE VA + L S ++ ELT++Q KYL
Sbjct: 528 TQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYL 582
>pir||S01302 adenosylhomocysteinase (EC 3.3.1.1) - fruit fly (Drosophila
melanogaster) >gi|7676|emb|CAA31566.1| (X13168)
S-adenosylhomocysteine hydrolase [Drosophila
melanogaster]
Length = 527
Score = 264 bits (667), Expect = 2e-69
Identities = 155/413 (37%), Positives = 232/413 (55%), Gaps = 4/413 (0%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+D+CVK IS + G ++I+ MP + +R+ +++KP KG I H+ ++A L+
Sbjct: 66 TDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQSAVLI 125
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL---DIR 122
L GA V AA N STQ+ V AALA+ G+ ++A RGE++EE++ +++A+ +
Sbjct: 126 EALVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQ 185
Query: 123 PNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSY 182
PN+I+DDG D L+ + + I G EE+ TGV RL + + L P I VNDS
Sbjct: 186 PNLILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSV 245
Query: 183 MKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEV 242
K FD Y S D + R T+++ GK VV+ GYG G+G A +G G V V EV
Sbjct: 246 TKNKFDTFYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEV 305
Query: 243 DPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDV 302
DPI AL+A MDGF V+ + E + D+ VTATGN I R+H MK+G I+ N GH
Sbjct: 306 DPICALQAAMDGFRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCS 365
Query: 303 EIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFAL 362
EI L + R V + DGR + LLA+GRLVNL + + ++ ++ +
Sbjct: 366 EIDVNGLHTPELTWERVRSQVDHIRWPDGRMIILLAEGRLVNL-SCSTISSFVVSVASST 424
Query: 363 QAKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
QA A + R + VY+LP+++DE VA + L + ++ ELT+EQ K++
Sbjct: 425 QALALIELFSAPGRYKSDVYLLPKKMDEYVASLHLATFDAHLTELTDEQSKFM 477
>dbj|BAA03710.1| (D16139) cytokinin binding protein CBP57 [Nicotiana sylvestris]
Length = 450
Score = 263 bits (665), Expect = 3e-69
Identities = 163/435 (37%), Positives = 236/435 (53%), Gaps = 49/435 (11%)
Query: 30 MPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAKVSAAASNPLSTQDDV 89
MP L R EF +PFKG +I +LH+ ++TA L+ TL A GA+V + N STQD
Sbjct: 1 MPGLMACRTEFGPSQPFKGAKITGSLHMTIQTAVLIETLTALGAEVRWCSCNIFSTQDHA 60
Query: 90 VAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP----NIIIDDGADMVSLVHTERK--- 142
AA+A++ V+A +GE+ +EY+ +ALD P ++I+DDG D L+H K
Sbjct: 61 AAAIARDSRAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDATLLIHEGVKAEE 120
Query: 143 --------------------------------------ELLDEIWGASEETTTGVIRLRA 164
++ + + G SEETTTGV RL
Sbjct: 121 EYAKSGKLPDPSSTDNAEFQLVLTIIRDGLKTDPLKYTKMKERLVGVSEETTTGVKRLYQ 180
Query: 165 MERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGR 224
M+ + L FP I VNDS K FDN YG S DG+MRAT++++AGK +V GYG G+
Sbjct: 181 MQANGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKVALVAGYGDVGK 240
Query: 225 GIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREH 284
G A + GA VIV E+DPI AL+A M+G V+++++ DIFVT TGN I +H
Sbjct: 241 GCAAALKQAGARVIVTEIDPICALQATMEGLQVLTLEDVVSDVDIFVTTTGNKDIIMVDH 300
Query: 285 FELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPRPNVTEYKLKD-GRRLYLLADGRL 342
MK+ AI+ N GHFD EI LE V+ +P + D + +LA+GRL
Sbjct: 301 MRKMKNNAIVCNIGHFDNEIDMLGLETFPGVKRITIKPQTDRWVFPDTNSGIIVLAEGRL 360
Query: 343 VNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERLEPRVYVLPREIDEMVARIKLQSM 400
+NL A GHP+ +M SF Q A+ + +++ + E +VYVLP+ +DE VA + L +
Sbjct: 361 MNLGCATGHPSFVMSCSFTNQVIAQLELWKEKSTGKYEKKVYVLPKHLDEKVAALHLGKL 420
Query: 401 GINIEELTEEQKKYL 415
G + +L+++Q Y+
Sbjct: 421 GARLTKLSKDQADYI 435
>gb|AAF47685.1| (AE003476) CG9977 gene product [Drosophila melanogaster]
Length = 521
Score = 258 bits (653), Expect = 7e-68
Identities = 153/416 (36%), Positives = 236/416 (55%), Gaps = 6/416 (1%)
Query: 5 TSDYCVKDISLAPE-GMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAF 63
+SD+CV++I G ++I+ + MP + +++ E KP K +I H+ +TA
Sbjct: 92 SSDFCVRNIGAQHAFGRREIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAV 151
Query: 64 LLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDI-- 121
L+ TL GA V AA N STQ++V AALA+ G+ ++A RGE++E+++ +++ ++
Sbjct: 152 LIETLVELGASVRWAACNIYSTQNEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNAEN 211
Query: 122 -RPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVND 180
+PN+I+DDG D L+ + + + G EE+ TGV RL + + L P + VND
Sbjct: 212 WQPNMILDDGGDATHLMLKKYPTMFKLVKGIVEESVTGVHRLYQLSKAGKLTVPAMNVND 271
Query: 181 SYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVV 240
S K FDN Y +S D + R+T+++ GK VVV GYG G+G A +G G V +
Sbjct: 272 SVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQVVVCGYGDVGKGCAQALKGQGCIVYIT 331
Query: 241 EVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHF 300
E+DPI AL+A MDGF V+ + E + DI VTATGN + REH + MK G I+ N GH
Sbjct: 332 EIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKNVVVREHMDKMKSGCIVCNMGHS 391
Query: 301 DVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSF 360
+ EI L + R V +G+ + LLA+GRLVNL + P+ + ++
Sbjct: 392 NTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLVNL-SCSSIPSFAVSITS 450
Query: 361 ALQAKA-AEYIKENHERLEPRVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
A QA A E R + VY+LP+++DE VA + L + ++ EL++EQ KY+
Sbjct: 451 ATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELSDEQAKYM 506
>pir||H83591 S-adenosyl-L-homocysteine hydrolase PA0432 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9946289|gb|AAG03821.1|AE004480_5 (AE004480)
S-adenosyl-L-homocysteine hydrolase [Pseudomonas
aeruginosa]
Length = 469
Score = 253 bits (640), Expect = 2e-66
Identities = 167/444 (37%), Positives = 247/444 (55%), Gaps = 34/444 (7%)
Query: 6 SDYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLL 65
+DY V DI+LA G +++ MP L +RR++ ++P KG +I +H+ ++T L+
Sbjct: 11 TDYKVADITLAAWGRRELIIAESEMPALMGLRRKYAGQQPLKGAKILGCIHMTIQTGVLI 70
Query: 66 LTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKAL--DIRP 123
TL A GA+V ++ N STQD AA+A G+ V+A +GE++EEY + + + D +P
Sbjct: 71 ETLVALGAEVRWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQP 130
Query: 124 ---NIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVND 180
N+++DDG D+ ++H + ++L+ I G +EETTTGV RL M ++ L+ P I VND
Sbjct: 131 WDANMVLDDGGDLTEILHKKYPQMLERIHGITEETTTGVHRLLDMLKNGTLKVPAINVND 190
Query: 181 SYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVV 240
S K DN+YG S D I R T+ L++GK +V+GYG G+G + R G V V
Sbjct: 191 SVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSSQSLRQEGMIVKVA 250
Query: 241 EVDPIKALEARMDGFLVMS------------MKEAAKIG--DIFVTATGNIKCIRREHFE 286
EVDPI A++A MDGF V+S +AA +G D+ VT TGN+ +
Sbjct: 251 EVDPICAMQACMDGFEVVSPYKNGINDGTEASIDAALLGKIDLIVTTTGNVNVCDANMLK 310
Query: 287 LMKDGAIMANAGHFDVEIWKPDL-EELAVEISNPRPNVTEYKLKDG------RRLYLLAD 339
+K A++ N GHFD EI + + A E P+ + KDG L LLA+
Sbjct: 311 ALKKRAVVCNIGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGKDGFDAHNDDYLILLAE 370
Query: 340 GRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEP--------RVYVLPREIDEM 391
GRLVNL A GHP+ IMD SFA Q A ++ E P V VLP+++DE
Sbjct: 371 GRLVNLGNATGHPSRIMDGSFANQVLAQIHLFEQKYADLPAAEKAKRLSVEVLPKKLDEE 430
Query: 392 VARIKLQSMGINIEELTEEQKKYL 415
VA ++ G + +LT +Q +Y+
Sbjct: 431 VALEMVKGFGGVVTQLTPKQAEYI 454
>emb|CAC09529.1| (AL356299) bK3216D2.1.1 (S-adenosylhomocysteine hydrolase (SAHH),
isoform 1) [Homo sapiens]
Length = 285
Score = 237 bits (599), Expect = 2e-61
Identities = 131/276 (47%), Positives = 172/276 (61%), Gaps = 3/276 (1%)
Query: 8 YCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLT 67
Y V DI LA G K +D MP L +R + KP KG RIA LH+ ++TA L+ T
Sbjct: 7 YKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIET 66
Query: 68 LKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP---N 124
L GA+V ++ N STQD AA+AK G+ VYA +GE+ EEY + + L + N
Sbjct: 67 LVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLN 126
Query: 125 IIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMK 184
+I+DDG D+ +L+HT+ +LL I G SEETTTGV L M + +L+ P I VNDS K
Sbjct: 127 MILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTK 186
Query: 185 YLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDP 244
FDN YG +S DGI RAT++++AGK VV GYG G+G A RG GA VI+ E+DP
Sbjct: 187 SKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 246
Query: 245 IKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCI 280
I AL+A M+G+ V +M EA + G+IFVT TG I I
Sbjct: 247 INALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDII 282
>gb|AAF19001.1|AF212157_1 (AF212157) S-adenosylhomocysteine hydrolase [Allium cepa]
Length = 312
Score = 177 bits (445), Expect = 2e-43
Identities = 111/300 (37%), Positives = 157/300 (52%), Gaps = 45/300 (15%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
+Y VKD+S A G +++ MP L R EF +PFKG RI +L + ++TA L+
Sbjct: 13 EYKVKDMSQADFGRLELELAEVDMPGLMACRTEFGPSQPFKGARITGSLLMTIQTAVLIE 72
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEEYYEFMNKALDIRP--- 123
TL A GA+V + N STQD AA+A++ V+A +GE+ +EY+ +ALD P
Sbjct: 73 TLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGG 132
Query: 124 -NIIIDDGADMVSLVH-----------------------------------------TER 141
++I+DDG D L+H T+
Sbjct: 133 PDLIVDDGGDATLLIHEGVKAEEEYEKNGTLPDPSSTDNAEFQIVLTIIRDGLKVDPTKY 192
Query: 142 KELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGI 201
+++ + + G SEETTTGV RL M+ L FP I VNDS K FDN YG S DG+
Sbjct: 193 RKMKERLVGVSEETTTGVKRLYQMQASGALLFPAINVNDSVTKSKFDNLYGCRHSLPDGL 252
Query: 202 MRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMK 261
MRAT++++AGK V GYG G+G A + GA VIV E+DPI AL+ + G V+ ++
Sbjct: 253 MRATDVMIAGKVAFVAGYGDVGKGCAAALKQAGARVIVSEIDPICALQPQWKGLQVLPLE 312
>gb|AAD20318.1| (AF105295) S-adenosyl-homocysteine hydrolase like protein;
SAHH-like protein [Alexandrium fundyense]
Length = 195
Score = 155 bits (389), Expect = 6e-37
Identities = 83/187 (44%), Positives = 115/187 (61%), Gaps = 2/187 (1%)
Query: 178 VNDSYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATV 237
VND K FDN YG S D IMRAT++++ GK ++ GYG G+G A+ RG GA V
Sbjct: 1 VNDCVTKSKFDNVYGCRHSLPD-IMRATDVMIGGKRALICGYGDVGKGCALAMRGAGARV 59
Query: 238 IVVEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIMANA 297
++ E+DPI AL+A M+GF V++++ DIF T TGN K I EH + MK+ AI+ N
Sbjct: 60 LITEIDPICALQACMEGFQVVTLESVVGEVDIFTTTTGNFKIITLEHMKKMKNNAIVGNI 119
Query: 298 GHFDVEIWKPDLEEL-AVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIM 356
GHFD EI +LE + +++ N + V + DG + +LA GRL+NL A GHP+ +M
Sbjct: 120 GHFDNEIEMAELEGMPGIKVENIKAQVDRFIFPDGHGIIVLASGRLLNLGCATGHPSFVM 179
Query: 357 DMSFALQ 363
SF Q
Sbjct: 180 SCSFTNQ 186
>gb|AAD52668.2| (AF178115) S-adenosyl-L-homocysteine hydrolase [Mycobacterium
bovis]
Length = 181
Score = 155 bits (388), Expect = 8e-37
Identities = 82/162 (50%), Positives = 104/162 (63%)
Query: 143 ELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIM 202
++ + + G +EETTTGV+RL L FP I VNDS K FDN+YGT S DGI
Sbjct: 15 KIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGIN 74
Query: 203 RATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKE 262
R T+ L+ GK V++ GYG G+G A +G GA V V E+DPI AL+A M+GF V++++E
Sbjct: 75 RGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEE 134
Query: 263 AAKIGDIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEI 304
A DI VTATGN I EH + MKD AI+ N GHFD EI
Sbjct: 135 AIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEI 176
>pir||T15035 adenosylhomocysteinase (EC 3.3.1.1) - parsley
>gi|169661|gb|AAA33855.1| (M62756)
S-adenosylhomocysteine hydrolase [Petroselinum crispum]
Length = 227
Score = 138 bits (345), Expect = 9e-32
Identities = 81/212 (38%), Positives = 122/212 (57%), Gaps = 4/212 (1%)
Query: 208 LVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIG 267
++AGK ++ GYG G+G A + GA VIV E+DPI AL+A M+G V+ +++
Sbjct: 1 MIAGKVALIAGYGDVGKGCAAAMKQAGARVIVTEIDPICALQATMEGLQVLPLEDVVSEV 60
Query: 268 DIFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEEL-AVEISNPRPNVTEY 326
DIFVT TGN I MK+ AI+ N GHFD EI LE V+ +P +
Sbjct: 61 DIFVTTTGNKDIIMVSDMRKMKNNAIVDNIGHFDNEIDMLGLETYPGVKRITIKPQTDRW 120
Query: 327 KLKD-GRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ--AKAAEYIKENHERLEPRVYV 383
D GR + +LA+GRL+NL A GHP+ +M SF Q A+ + +++ + E +VYV
Sbjct: 121 VFPDTGRGIIILAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKYEKKVYV 180
Query: 384 LPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
P+ +DE VA + L +G + +L+++Q Y+
Sbjct: 181 CPKHLDEKVAALHLGKLGAKLTKLSKDQADYI 212
>gb|AAB88189.1| (AF035319) similar to S-adenosylhomocysteine hydrolase [Homo
sapiens]
Length = 218
Score = 131 bits (325), Expect = 2e-29
Identities = 75/199 (37%), Positives = 110/199 (54%), Gaps = 2/199 (1%)
Query: 218 GYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNI 277
GYG G+G + LGA V + E+DPI AL+A MDGF V+ + E + D+ +T TGN
Sbjct: 6 GYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNK 65
Query: 278 KCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLL 337
+ REH + MK+ I+ N GH + EI L + R V DG+R+ LL
Sbjct: 66 NVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLL 125
Query: 338 ADGRLVNLVAADGHPAEIMDMSFALQAKA-AEYIKENHERLEPRVYVLPREIDEMVARIK 396
A+GRL+NL + P ++ ++ QA A E R + VY+LP+++DE VA +
Sbjct: 126 AEGRLLNL-SCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLH 184
Query: 397 LQSMGINIEELTEEQKKYL 415
L S ++ ELT++Q KYL
Sbjct: 185 LPSFDAHLTELTDDQAKYL 203
>gi|11498491 S-adenosylhomocysteinase hydrolase (ahcY-1) [Archaeoglobus
fulgidus] >gi|7482896|pir||F69360 adenosylhomocysteinase
(EC 3.3.1.1) homolog ahcY-1 - Archaeoglobus fulgidus
>gi|2649719|gb|AAB90357.1| (AE001043)
S-adenosylhomocysteinase hydrolase (ahcY-1)
[Archaeoglobus fulgidus]
Length = 326
Score = 109 bits (269), Expect = 8e-23
Identities = 95/323 (29%), Positives = 154/323 (47%), Gaps = 36/323 (11%)
Query: 51 IAATLHLEMKTAFLLLTLKAGGAKVSAAASNPLSTQDDVVAALAKEGVKVYAIRGESKEE 110
+A + LE K+A L+ L V AA + ST+ +VV+ L ++GV+V R E
Sbjct: 16 LAICIPLEYKSACLIYELSRY-TNVYAAKLDDFSTKPEVVSWLKEKGVEVKMKRDVVNAE 74
Query: 111 YYEFMNKALDIRPNIIIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKV 170
Y+ +D A + + KE L + E T TG LR M+
Sbjct: 75 YF--------------LDCAAVLSRVAVKSGKERLKVV----ELTKTGEEYLRKMD---- 112
Query: 171 LRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRA 230
+R I+++ S +K +N +GT D ++R N+ + GK +++G+G GRG A
Sbjct: 113 VRMKAISLDSSTLKGTGENTHGTAFGLLDALLRL-NVFLPGKKALILGFGRVGRGCARLL 171
Query: 231 RGLGATVIVVEVDPIKALEARMDGFLVMSMKEAAKIGDIFVTATGNIKCIRREHFELMKD 290
+ +G V V + D + +EA +GF V E ++ VT TG + +E E + D
Sbjct: 172 KSVGCDVAVWDNDETRQIEALYEGFRV----EKDFTAEVVVTCTGVKGVLGKEELEEISD 227
Query: 291 GAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADG 350
G+I+ N G ++EI E A E+ V EY++ G+R +L+ADG NL G
Sbjct: 228 GSIILNMG-AEMEI------EPAGELIKDYGLVKEYEIA-GKRYFLVADGYAANLALGSG 279
Query: 351 HPAEIMDMSFALQAKAAEYIKEN 373
P E+MD +F+ A ++ +
Sbjct: 280 TPIEVMDRTFSAAILALNHLSRS 302
>gb|AAD56027.1|AF181566_1 (AF181566) S-adenosyl-L-homocysteine hydrolase [Solanum chacoense]
Length = 171
Score = 100 bits (246), Expect = 4e-20
Identities = 58/120 (48%), Positives = 73/120 (60%), Gaps = 3/120 (2%)
Query: 126 IIDDGADMVSLVHTERKELLDEIWGASEETTTGVIRLRAMERDKVLRFPVIAVNDSYMKY 185
II + L +T+ KE L G SEETTTGV RL M+ + L FP I VNDS K
Sbjct: 55 IIKESLKTDPLRYTKMKERLV---GVSEETTTGVKRLYQMQANGTLLFPAINVNDSVTKS 111
Query: 186 LFDNRYGTGQSTWDGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPI 245
FDN YG S DG+MRAT++++AGK +V GYG G+G A + GA VIV ++DPI
Sbjct: 112 KFDNLYGCRHSLPDGLMRATDVMIAGKVALVAGYGDVGKGCAAAMKQAGARVIVTDIDPI 171
>pir||S06394 adenosylhomocysteinase (EC 3.3.1.1) - slime mold (Dictyostelium
discoideum) (fragment) >gi|7205|emb|CAA31040.1| (X12523)
S-adenosyl-L-homocysteine hydrolase (176 AA)
[Dictyostelium discoideum]
Length = 176
Score = 99.1 bits (243), Expect = 9e-20
Identities = 62/148 (41%), Positives = 85/148 (56%), Gaps = 4/148 (2%)
Query: 269 IFVTATGNIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEYKL 328
IFVT TG +R EHF +MK+ AI+ N GHFD EI L A + +P V+ Y L
Sbjct: 17 IFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNGNAKK-DTVKPQVSRYTL 75
Query: 329 KDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQ-AKAAEYIKENHERLEPRVYVLPRE 387
+G + LLA+GRLVNL GHP+ +M S + A+ A + K E V+ LP+
Sbjct: 76 ANGVHIILLAEGRLVNLGCGTGHPSFVMSNSSVTKLAQIALWTKT--EEYPLGVHFLPKI 133
Query: 388 IDEMVARIKLQSMGINIEELTEEQKKYL 415
+DE VAR+ L +G + LTE+Q +YL
Sbjct: 134 LDEEVARLHLDQLGAKLTTLTEKQSEYL 161
>gb|AAD29674.1|AF129871_1 (AF129871) S-adenosyl-L-homocysteine hydrolase [Gossypium hirsutum]
Length = 102
Score = 91.7 bits (224), Expect = 1e-17
Identities = 45/96 (46%), Positives = 63/96 (64%)
Query: 199 DGIMRATNLLVAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVM 258
DG+MRAT++++AGK VV GYG G+G A + GA VIV E+DPI AL+A M+G V+
Sbjct: 7 DGLMRATDVMIAGKVAVVCGYGDAGKGCAAALKQAGARVIVTEIDPICALQALMEGLQVL 66
Query: 259 SMKEAAKIGDIFVTATGNIKCIRREHFELMKDGAIM 294
++++ DIFVT TGN I H MK+ A++
Sbjct: 67 TLEDVVSEADIFVTTTGNKDIIMVNHMRKMKNNAVV 102
>gb|AAF70071.1|AF252255_1 (AF252255) S-adenosyl-L-homocysteinase II [Lupinus luteus]
Length = 90
Score = 90.1 bits (220), Expect = 4e-17
Identities = 48/90 (53%), Positives = 58/90 (64%)
Query: 153 EETTTGVIRLRAMERDKVLRFPVIAVNDSYMKYLFDNRYGTGQSTWDGIMRATNLLVAGK 212
EETTTGV RL M+ + L FP I VNDS K FDN YG S DG+MRAT++++AGK
Sbjct: 1 EETTTGVKRLYQMQANGTLLFPAINVNDSVTKRQFDNLYGCRHSLPDGLMRATDVMIAGK 60
Query: 213 NVVVVGYGWCGRGIAMRARGLGATVIVVEV 242
VV GYG G+G A + GA VIV E+
Sbjct: 61 VAVVAGYGDVGKGCASALKQAGARVIVTEI 90
>gb|AAD52667.2| (AF178114) S-adenosyl-L-homocysteine hydrolase [Mycobacterium
bovis]
Length = 140
Score = 82.7 bits (201), Expect = 7e-15
Identities = 47/115 (40%), Positives = 69/115 (59%), Gaps = 9/115 (7%)
Query: 7 DYCVKDISLAPEGMKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLL 66
D+ + D+SLA G K++ MP L +RRE+ E +P KG RI+ +LH+ ++TA L+
Sbjct: 6 DFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIE 65
Query: 67 TLKAGGAKVSAAASNPLSTQDDVVAALA---------KEGVKVYAIRGESKEEYY 112
TL A GA+V A+ N STQD AA+ +GV V+A +GE+ EEY+
Sbjct: 66 TLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYW 120
>sp|P26799|SAHH_STRFR ADENOSYLHOMOCYSTEINASE (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE)
(ADOHCYASE) >gi|98945|pir||S22958 adenosylhomocysteinase
(EC 3.3.1.1) - Streptomyces fradiae (fragment)
Length = 120
Score = 76.1 bits (184), Expect = 7e-13
Identities = 37/96 (38%), Positives = 59/96 (60%)
Query: 320 RPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKENHERLEP 379
+P V + DG+++ +L++GRL+NL A GHP+ +M SFA Q A + E+
Sbjct: 10 KPQVHTWTFADGKKIIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELYTKPEQYPT 69
Query: 380 RVYVLPREIDEMVARIKLQSMGINIEELTEEQKKYL 415
VYVLP+ +DE VAR+ L ++G+ + L EQ +Y+
Sbjct: 70 DVYVLPKHLDEKVARLHLDALGVKLTTLRPEQAEYI 105
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.320 0.136 0.393
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 150061037
Number of Sequences: 2977
Number of extensions: 6000481
Number of successful extensions: 19303
Number of sequences better than 1.0e-10: 77
Number of HSP's better than 0.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 19072
Number of HSP's gapped (non-prelim): 101
length of query: 422
length of database: 189,106,746
effective HSP length: 57
effective length of query: 365
effective length of database: 154,992,987
effective search space: 56572440255
effective search space used: 56572440255
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 166 (69.1 bits)