BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB1441 (pyk) DE:PYRUVATE KINASE (EC 2.7.1.40) (PK)
         (478 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||G75052 pyruvate kinase (EC 2.7.1.40) (pk) PAB1441 - Pyrococ...   930  0.0
pir||F71171 probable pyruvate kinase - Pyrococcus horikoshii >gi...   807  0.0
dbj|BAB06882.1| (AP001517) pyruvate kinase [Bacillus halodurans]      374  e-103
pir||B72406 pyruvate kinase - Thermotoga maritima (strain MSB8) ...   357  1e-97
sp|P80885|KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE PROTEIN 17...   357  2e-97
pir||S27330 pyruvate kinase (EC 2.7.1.40) isoform 1 - Bacillus s...   356  2e-97
sp|Q02499|KPYK_BACST PYRUVATE KINASE (PK) >gi|421472|pir||S29783...   356  2e-97
sp|Q55863|KPY1_SYNY3 PYRUVATE KINASE 1 (PK 1) >gi|7434447|pir||S...   355  5e-97
gb|AAC12962.1| (U73943) pyruvate kinase I [Bacillus subtilis]         353  3e-96
sp|P51181|KPYK_BACLI PYRUVATE KINASE (PK) >gi|1361386|pir||JC422...   344  2e-93
dbj|BAA89788.1| (AB037182) pyruvate kinase [Selenomonas ruminant...   335  8e-91
sp|P51182|KPYK_BACPY PYRUVATE KINASE (PK) >gi|1363364|pir||JC421...   332  6e-90
pir||B75251 pyruvate kinase - Deinococcus radiodurans (strain R1...   332  6e-90
emb|CAB70653.1| (AL137242) pyruvate kinase [Streptomyces coelico...   332  6e-90
sp|P14178|KPY1_ECOLI PYRUVATE KINASE I (PK-1) >gi|7428041|pir||D...   328  8e-89
sp|Q56301|KPYK_THELI PYRUVATE KINASE (PK) >gi|2147994|pir||A5741...   327  2e-88
sp|P73534|KPY2_SYNY3 PYRUVATE KINASE 2 (PK 2) >gi|7434448|pir||S...   326  2e-88
pdb|1PKY|A Chain A, Pyruvate Kinase From E. Coli In The T-State ...   326  3e-88
pdb|1E0U|A Chain A, Structure R271l Mutant Of E. Coli Pyruvate K...   325  5e-88
pdb|1E0T|A Chain A, R292d Mutant Of E. Coli Pyruvate Kinase >gi|...   323  2e-87
pir||S29004 pyruvate kinase (EC 2.7.1.40) I - Escherichia coli >...   323  3e-87
sp|P77983|KPY1_SALTY PYRUVATE KINASE I (PK-1) >gi|1526982|emb|CA...   323  4e-87
dbj|BAA89378.1| (AB025342) ORF4 [Moritella marina]                    318  7e-86
pir||F81382 pyruvate kinase (EC 2.7.1.40) Cj0392c [imported] - C...   314  1e-84
pir||T35759 pyruvate kinase - Streptomyces coelicolor >gi|568990...   310  3e-83
pir||C82316 pyruvate kinase I VC0485 [imported] - Vibrio cholera...   303  3e-81
sp|Q92122|KPYK_XENLA PYRUVATE KINASE, MUSCLE ISOZYME (CYTOSOLIC ...   301  1e-80
pir||T27928 hypothetical protein ZK593.1 - Caenorhabditis elegan...   300  2e-80
pir||D83459 pyruvate kinase I PA1498 [imported] - Pseudomonas ae...   298  7e-80
sp|P21599|KPY2_ECOLI PYRUVATE KINASE II (PK-2) >gi|321866|pir||S...   295  8e-79
sp|O44006|KPYK_EIMTE PYRUVATE KINASE (PK) >gi|2854033|gb|AAC0252...   294  1e-78
sp|Q44473|KPY4_AGRVI PYRUVATE KINASE (PK) >gi|805294|gb|AAA68700...   294  1e-78
sp|Q46078|KPYK_CORGL PYRUVATE KINASE (PK) >gi|2127424|pir||I4084...   293  2e-78
sp|Q29536|KPYR_CANFA PYRUVATE KINASE, ISOZYME R >gi|7579924|gb|A...   293  2e-78
gb|AAA60104.1| (M15465) pyruvate kinase [Homo sapiens]                292  5e-78
pir||T21360 hypothetical protein F25H5.3b - Caenorhabditis elega...   292  5e-78
pir||T21361 hypothetical protein F25H5.3a - Caenorhabditis elega...   292  5e-78
pir||B82130 pyruvate kinase II VC2008 [imported] - Vibrio choler...   292  5e-78
pir||S64635 pyruvate kinase (EC 2.7.1.40), muscle splice form M1...   292  7e-78
gb|AAG21457.1|AC021894_17 (AC021894) Pyruvate Kinase copy 2 [Lei...   292  7e-78
sp|P94939|KPYK_MYCIT PYRUVATE KINASE (PK) >gi|1750255|gb|AAB3921...   291  9e-78
sp|P11979|KPY1_FELCA PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINAS...   291  1e-77
sp|P34038|KPYK_LACDE PYRUVATE KINASE >gi|1154865|emb|CAA50527.1|...   291  1e-77
gb|AAA92535.1| (U47654) pyruvate kinase PK-R isoenzyme [Homo sap...   290  3e-77
gb|AAA92536.1| (U47654) pyruvate kinase PK-L isoenzyme [Homo sap...   290  3e-77
pir||A30150 pyruvate kinase (EC 2.7.1.40) isoform R (erythroid) ...   290  3e-77
gi|10835121 pyruvate kinase, liver and RBC; Pyruvate kinase, liv...   290  3e-77
pir||KIHUPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice fo...   290  3e-77
pir||KIHUPL pyruvate kinase (EC 2.7.1.40), hepatic splice form L...   290  3e-77
sp|P11980|KPY1_RAT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE ...   289  3e-77
sp|P11981|KPY2_RAT PYRUVATE KINASE, M2 ISOZYME >gi|92716|pir||A2...   289  4e-77
gb|AAA41882.1| (M17091) R-pyruvate kinase [Rattus norvegicus]         289  4e-77
gb|AAA41883.1| (M17091) L-pyruvate kinase [Rattus norvegicus]         289  4e-77
gi|6981360 pyruvate kinase, liver and RBC [Rattus norvegicus] >g...   289  6e-77
pir||A23612 pyruvate kinase (EC 2.7.1.40) L - rat >gi|206199|gb|...   289  6e-77
sp|P12928|KPYR_RAT PYRUVATE KINASE, ISOZYMES R/L (L-PK)               289  6e-77
sp|P70789|KPY3_AGRVI PYRUVATE KINASE (PK) >gi|984370|gb|AAB61625...   288  8e-77
pdb|1A49|A Chain A, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kin...   288  8e-77
sp|P11974|KPY1_RABIT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINAS...   288  8e-77
gb|AAC48536.1| (U44751) pyruvate kinase [Oryctolagus cuniculus] ...   287  1e-76
sp|O06134|KPYK_MYCTU PYRUVATE KINASE (PK) >gi|7434446|pir||G7055...   287  1e-76
sp|P14618|KPY1_HUMAN PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINAS...   287  2e-76
pir||B81239 pyruvate kinase II NMB0089 [imported] - Neisseria me...   287  2e-76
pir||KIRTPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice fo...   287  2e-76
sp|P00548|KPYK_CHICK PYRUVATE KINASE, MUSCLE ISOZYME >gi|66858|p...   287  2e-76
gi|4505839 pyruvate kinase, muscle; Pyruvate kinase-3; Thyroid h...   287  2e-76
pdb|1PKN|   Pyruvate Kinase (E.C.2.7.1.40) Complexed With Mangan...   287  2e-76
gi|8567390 pyruvate kinase liver and red blood cell [Mus musculu...   287  2e-76
pdb|1PKL|G Chain G, The Structure Of Leishmania Pyruvate Kinase ...   287  2e-76
gi|6755074 pyruvate kinase 3 [Mus musculus] >gi|1405933|emb|CAA6...   286  3e-76
sp|P52480|KPY2_MOUSE PYRUVATE KINASE, M2 ISOZYME                      286  3e-76
pir||A54113 pyruvate kinase (EC 2.7.1.40) - rabbit                    286  4e-76
pir||A33983 pyruvate kinase (EC 2.7.1.40) isozyme M2 - human >gi...   286  5e-76
pir||S55921 pyruvate kinase (EC 2.7.1.40) isozyme M2 - mouse >gi...   286  5e-76
pir||G82011 pyruvate kinase (EC 2.7.1.40) NMA0177 [imported] - N...   285  7e-76
sp|P30614|KPYK_YARLI PYRUVATE KINASE >gi|424047|gb|AAA18520.1| (...   284  1e-75
gb|AAB86587.1| (AF032389) pyruvate kinase; ATP:pyruvate 2-o-phos...   284  1e-75
sp|O18919|KPY2_RABIT PYRUVATE KINASE, M2 ISOZYME                      284  1e-75
sp|Q27686|KPYK_LEIME PYRUVATE KINASE (PK) >gi|577072|emb|CAA5289...   283  3e-75
sp|Q40546|KPYG_TOBAC PYRUVATE KINASE ISOZYME G, CHLOROPLAST PREC...   282  6e-75
pir||E82757 pyruvate kinase type II XF0824 [imported] - Xylella ...   282  6e-75
dbj|BAB12236.1| (AB032276) pyruvate kinase [Aspergillus oryzae]       282  7e-75
sp|O51323|KPYK_BORBU PYRUVATE KINASE (PK) >gi|7434449|pir||C7014...   279  4e-74
sp|Q57572|KPYK_METJA PYRUVATE KINASE (PK) >gi|2129228|pir||D6431...   279  6e-74
sp|P22360|KPYK_EMENI PYRUVATE KINASE (PK) >gi|283342|pir||S27364...   277  2e-73
gb|AAK41255.1| Pyruvate kinase (pyK) [Sulfolobus solfataricus]        276  3e-73
pir||S26869 pyruvate kinase (EC 2.7.1.40) pkiA - Aspergillus niger    275  7e-73
sp|Q12669|KPYK_ASPNG PYRUVATE KINASE (PK) >gi|250607|gb|AAB22392...   274  2e-72
dbj|BAB10461.1| (AB005234) pyruvate kinase [Arabidopsis thaliana]     274  2e-72
sp|O65595|KPYC_ARATH PROBABLE PYRUVATE KINASE, CYTOSOLIC ISOZYME...   272  5e-72
gb|AAF81342.1|AC007767_22 (AC007767) Strong similarity to a pyru...   272  5e-72
dbj|BAB10006.1| (AB006697) pyruvate kinase [Arabidopsis thaliana]     272  6e-72
sp|O62619|KPYK_DROME PYRUVATE KINASE (PK) >gi|3108349|gb|AAC1580...   272  8e-72
emb|CAA66194.1| (X97579) pyruvate kinase [Agaricus bisporus]          272  8e-72
emb|CAA62560.1| (X91106) pyruvate kinase [Agaricus bisporus]          272  8e-72
gb|AAG18902.1| (AE004992) pyruvate kinase; PykA [Halobacterium s...   272  8e-72
gb|AAC28104.1| (AF079586) pyruvate kinase; PK [Zymomonas mobilis]     271  1e-71
sp|P30615|KPY1_TRYBB PYRUVATE KINASE 1 (PK 1) >gi|102108|pir||S1...   271  1e-71
sp|P30616|KPY2_TRYBB PYRUVATE KINASE 2 (PK 2) >gi|102107|pir||S1...   271  1e-71
sp|P43924|KPYK_HAEIN PYRUVATE KINASE (PK) >gi|1075198|pir||C6413...   271  1e-71
gb|AAF55979.1| (AE003738) PyK gene product [Drosophila melanogas...   271  1e-71
sp|P57404|KPYK_BUCAI PYRUVATE KINASE (PK) >gi|10038993|dbj|BAB13...   271  1e-71
sp|O05118|KPYK_METEX PYRUVATE KINASE (PK) >gi|1907336|gb|AAB6649...   270  2e-71
dbj|BAB10440.1| (AB009055) pyruvate kinase [Arabidopsis thaliana]     270  2e-71
dbj|BAB11262.1| (AB009049) pyruvate kinase [Arabidopsis thaliana]     269  4e-71
sp|P32044|KPYK_THEAC PYRUVATE KINASE (PK) >gi|10640173|emb|CAC12...   269  4e-71
gi|6319279 Pyruvate kinase; Cdc19p [Saccharomyces cerevisiae] >g...   268  7e-71
sp|Q10208|KPYK_SCHPO PYRUVATE KINASE >gi|7493249|pir||T38890 pyr...   268  1e-70
pir||T45166 pyruvate kinase (EC 2.7.1.40) [imported] - fission y...   267  2e-70
gb|AAF05863.1|AC011698_14 (AC011698) putative pyruvate kinase [A...   266  3e-70
pir||F81684 pyruvate kinase TC0609 [imported] - Chlamydia murida...   266  4e-70
pir||JC2456 pyruvate kinase (EC 2.7.1.40) - Trypanoplasma borell...   265  6e-70
gb|AAF55980.2| (AE003738) CG7069 gene product [Drosophila melano...   265  1e-69
gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococc...   263  2e-69
pir||JC1267 pyruvate kinase (EC 2.7.1.40) - yeast (Yarrowia lipo...   262  5e-69
dbj|BAB01059.1| (AB023041) pyruvate kinase [Arabidopsis thaliana]     262  5e-69
emb|CAA24631.1| (V01321) pyruvate kinase [Saccharomyces cerevisiae]   262  7e-69
pir||E83104 pyruvate kinase II PA4329 [imported] - Pseudomonas a...   261  9e-69
dbj|BAA88185.1| (AP000836) ESTs AU081247(C50004),AU068940(C51113...   260  2e-68
sp|P94685|KPYK_CHLTR PYRUVATE KINASE (PK) >gi|7434455|pir||G7152...   259  4e-68
sp|Q42954|KPYC_TOBAC PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|5420...   258  1e-67
gi|6324923 pyruvate kinase; Pyk2p [Saccharomyces cerevisiae] >gi...   257  2e-67
sp|Q42806|KPYC_SOYBN PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|7434...   256  4e-67
dbj|BAA95686.1| (AB042618) pyruvate kinase [Hydrogenophilus ther...   254  1e-66
pir||T47704 pyruvate kinase-like protein - Arabidopsis thaliana ...   252  5e-66
pir||A82427 pyruvate kinase II VCA0708 [imported] - Vibrio chole...   252  5e-66
gb|AAB41226.1| (U83196) pyruvate kinase [Chlamydia trachomatis]       251  1e-65
sp|Q07637|KPYK_LACLA PYRUVATE KINASE >gi|421428|pir||B40620 pyru...   247  2e-64
gb|AAF44707.1| (AF242871) cytosolic pyruvate kinase [Lilium long...   244  2e-63
sp|P22200|KPYC_SOLTU PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|1004...   243  2e-63
pir||JC1481 pyruvate kinase (EC 2.7.1.40), cytosolic - potato         242  7e-63
sp|P31865|KPYK_TRIRE PYRUVATE KINASE >gi|484468|pir||JN0780 pyru...   241  1e-62
pir||A72119 pyruvate kinase CP0677 [imported] - Chlamydophila pn...   238  1e-61
sp|Q40545|KPYA_TOBAC PYRUVATE KINASE ISOZYME A, CHLOROPLAST PREC...   236  3e-61
pir||S51946 pyruvate kinase (EC 2.7.1.40) A, chloroplast - commo...   236  3e-61
dbj|BAA98307.1| (AP002545) pyruvate kinase [Chlamydophila pneumo...   236  5e-61
sp|P55964|KPYG_RICCO PYRUVATE KINASE ISOZYME G, CHLOROPLAST           235  7e-61
sp|Q43117|KPYA_RICCO PYRUVATE KINASE ISOZYME A, CHLOROPLAST PREC...   235  1e-60
gb|AAA27629.1| (M98350) pyruvate kinase-like protein [unidentifi...   234  2e-60
sp|P47458|KPYK_MYCGE PYRUVATE KINASE (PK) >gi|1361781|pir||H6422...   219  7e-56
pir||T47720 pyruvate kinase-like protein - Arabidopsis thaliana ...   218  1e-55
pir||T10054 pyruvate kinase (EC 2.7.1.40) isoform beta - castor ...   214  1e-54
sp|P78031|KPYK_MYCPN PYRUVATE KINASE (PK) >gi|2146579|pir||S7385...   212  1e-53
dbj|BAA15445.1| (D90810) Pyruvate kinase (EC 2.7.1.40) I [Escher...   210  4e-53
pir||T47556 pyruvate kinase-like protein - Arabidopsis thaliana ...   199  5e-50
gb|AAD24640.1|AC006919_20 (AC006919) putative pyruvate kinase [A...   178  2e-43
pir||B82923 pyruvate kinase UU186 [imported] - Ureaplasma urealy...   176  6e-43
sp|O30853|KPY1_PHOLE PYRUVATE KINASE I (PK-1) >gi|7434445|pir||P...   153  3e-36
gb|AAF19604.1|AF150875_1 (AF150875) pyruvate kinase [Giardia int...   146  6e-34
dbj|BAA16043.1| (D90853) Pyruvate kinase (EC 2.7.1.40) I [Escher...   118  1e-25
gb|AAB69999.1| (AF012877) pyruvate kinase [Spiroplasma citri]          87  3e-16

>pir||G75052 pyruvate kinase (EC 2.7.1.40) (pk) PAB1441 - Pyrococcus abyssi
           (strain Orsay) >gi|5458829|emb|CAB50316.1| (AJ248287)
           PYRUVATE KINASE (EC 2.7.1.40) (PK) [Pyrococcus abyssi]
           Length = 478
           
 Score =  930 bits (2377), Expect = 0.0
 Identities = 478/478 (100%), Positives = 478/478 (100%)

Query: 1   MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI 60
           MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI
Sbjct: 1   MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI 60

Query: 61  SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120
           SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR
Sbjct: 61  SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120

Query: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
           LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM
Sbjct: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180

Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
           EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK
Sbjct: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
           ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV
Sbjct: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
           TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT
Sbjct: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
           RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM
Sbjct: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420

Query: 421 FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
           FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA
Sbjct: 421 FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478


>pir||F71171 probable pyruvate kinase - Pyrococcus horikoshii
           >gi|3256976|dbj|BAA29659.1| (AP000002) 478aa long
           hypothetical pyruvate kinase [Pyrococcus horikoshii]
           Length = 478
           
 Score =  807 bits (2061), Expect = 0.0
 Identities = 402/478 (84%), Positives = 445/478 (92%)

Query: 1   MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI 60
           M  M+LP HKTKIVATIGPAT+S+ MIKKLIE G++V R+NFSHG+FEEHAK+IE VR+ 
Sbjct: 1   MRRMKLPSHKTKIVATIGPATNSKKMIKKLIEAGMNVARINFSHGTFEEHAKIIEMVREQ 60

Query: 61  SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120
           SQKLDRRVAILADLPGLKIRVGEIKGGYVEL+RGEKV LTT+D+ GDETTIPVEYKDFP+
Sbjct: 61  SQKLDRRVAILADLPGLKIRVGEIKGGYVELERGEKVTLTTKDIEGDETTIPVEYKDFPK 120

Query: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
           LVSKGDVIYLSDGYIVLRVE+V+  +VEAVV+SGGKLFSRKGINIPKAYLPVEA+TPRD+
Sbjct: 121 LVSKGDVIYLSDGYIVLRVEDVKENEVEAVVISGGKLFSRKGINIPKAYLPVEAITPRDI 180

Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
           EI+KFAIE GVDAIGLSFVG+VYDVLK KSFLE+N A D FVI+KIERPDAVRNF+EIL 
Sbjct: 181 EIMKFAIEHGVDAIGLSFVGNVYDVLKAKSFLERNGAGDTFVIAKIERPDAVRNFNEILN 240

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
           A+DGIMIARGDLGVEMPIE+LPILQK LIRKAN EGKPVITATQMLVSMT EKVPTRAEV
Sbjct: 241 AADGIMIARGDLGVEMPIEQLPILQKRLIRKANMEGKPVITATQMLVSMTMEKVPTRAEV 300

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
           TDVANAILDGTDAVMLSEETA+GKFPI+AV+MMA+IAKVTEEYRESFG++R+RE +E   
Sbjct: 301 TDVANAILDGTDAVMLSEETAVGKFPIEAVEMMARIAKVTEEYRESFGITRMREFLEGTK 360

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
           RGTIKEAI RSIIDA+CT+ IK+ILTPT+TGRTARLISRFKPKQWI  FST E+VCNNLM
Sbjct: 361 RGTIKEAITRSIIDAICTIGIKFILTPTKTGRTARLISRFKPKQWILAFSTREKVCNNLM 420

Query: 421 FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
           FSYGVY FC+EEGF+E DI+RLIKGLGLV SDDIVLMTEGKPIEKT+GTNSIKIFQIA
Sbjct: 421 FSYGVYPFCMEEGFNENDIVRLIKGLGLVGSDDIVLMTEGKPIEKTVGTNSIKIFQIA 478


>dbj|BAB06882.1| (AP001517) pyruvate kinase [Bacillus halodurans]
           Length = 584
           
 Score =  374 bits (951), Expect = e-103
 Identities = 204/472 (43%), Positives = 295/472 (62%), Gaps = 7/472 (1%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGPA+ S   +++L+E G++V RLNFSHG FEEH   I+ +R+ ++++ + VA
Sbjct: 3   KTKIVCTIGPASESVEKLEQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAKRIGKTVA 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL D  G +IR   ++GG  ELK G+++V++ ++VVG    I V Y      V  G  I 
Sbjct: 63  ILLDTKGPEIRTQTLEGGVAELKAGQELVISMKEVVGTSERISVTYPGLVHDVVPGAKIL 122

Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
           L DG I L V EVR Q++   V++ G L ++KG+N+P   + +  +T +D   IKF IEQ
Sbjct: 123 LDDGLIGLEVVEVRDQEILTKVLNSGTLKNKKGVNVPNVSVNLPGITEKDAADIKFGIEQ 182

Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
           GVD I  SFV    DVL+++  LE++ AE + +I KIE  + V N +EIL+ SDG+M+AR
Sbjct: 183 GVDFIAASFVRRAQDVLEIRELLEQHGAEHIKIIPKIENQEGVDNIEEILEVSDGLMVAR 242

Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
           GDLGVE+P E +P++QK LI+K N   KPVITATQML SM     PTRAE +DVANAI D
Sbjct: 243 GDLGVEIPAEEVPLVQKSLIKKCNLVAKPVITATQMLDSMQRNPRPTRAEASDVANAIFD 302

Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
           GTDA+MLS ETA G +P++AV+ M++IA   E   ++     +        R TI  AI+
Sbjct: 303 GTDAIMLSGETAAGDYPVEAVQTMSRIA---ERAEQALNYQEILSKHTKEARTTITSAIS 359

Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
           +S+      LN   ILT T +G TAR++++++PK  I   ++NE V   L   +GVY+  
Sbjct: 360 QSVGHTAFNLNASAILTATESGHTARVVAKYRPKSPIVAVTSNETVVRQLALVWGVYSIL 419

Query: 430 LEEGFDERDIIRLIKGLG----LVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
            EE     D++++         LV+  D+V++T G P+ +T  TN +K+  I
Sbjct: 420 GEEAETTDDMLQVTVETALKSQLVKQGDLVVITAGVPVGETGTTNIMKVHVI 471


>pir||B72406 pyruvate kinase - Thermotoga maritima (strain MSB8)
           >gi|4980705|gb|AAD35300.1|AE001705_11 (AE001705)
           pyruvate kinase [Thermotoga maritima]
           Length = 466
           
 Score =  357 bits (907), Expect = 1e-97
 Identities = 204/471 (43%), Positives = 291/471 (61%), Gaps = 13/471 (2%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
           TKIV T+GP T S  MI+K+I+ GV+V R+N SHG + E  + I K++D+ +K  + VAI
Sbjct: 4   TKIVCTVGPRTDSYEMIEKMIDLGVNVFRINTSHGDWNEQEQKILKIKDLREKKKKPVAI 63

Query: 71  LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYL 130
           L DL G KIR G ++  +VELK G+   LTT++++G+E  + V     P+ V KGD I L
Sbjct: 64  LIDLAGPKIRTGYLEKEFVELKEGQIFTLTTKEILGNEHIVSVNLSSLPKDVKKGDTILL 123

Query: 131 SDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQG 190
           SDG IVL V E    +V+ VV  GGK+  R+G+N+P A L VE++T RD E IK      
Sbjct: 124 SDGEIVLEVIETTDTEVKTVVKVGGKITHRRGVNVPTADLSVESITDRDREFIKLGTLHD 183

Query: 191 VDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARG 250
           V+   LSFV    DVLK K  + K+  +++ VISKIE   A+   +EI+K SDGIM+ARG
Sbjct: 184 VEFFALSFVRKPEDVLKAKEEIRKH-GKEIPVISKIETKKALERLEEIIKVSDGIMVARG 242

Query: 251 DLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDG 310
           DLGVE+PIE +PI+QKE+I+ +    KPVI ATQ+L SM     PTRAEVTD+ANAI DG
Sbjct: 243 DLGVEIPIEEVPIVQKEIIKLSKYYSKPVIVATQILESMIENPFPTRAEVTDIANAIFDG 302

Query: 311 TDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIAR 370
            DA++L+ ETA+GK P++A+K+++K+AK  E+  E F        +E  T   I EAI+ 
Sbjct: 303 ADALLLTAETAVGKHPLEAIKVLSKVAKEAEKKLEFF------RTIEYDT-SDISEAISH 355

Query: 371 SIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCL 430
           +      +LN K I+TPT +G TA  +S++   Q I   +  E+    L     V     
Sbjct: 356 ACWQLSESLNAKLIITPTISGSTAVRVSKYNVSQPIVALTPEEKTYYRLSLVRKVIPVLA 415

Query: 431 EEGFDERDII----RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           E+   E + I    + ++ +GL E  D+V++T G P  K   TN+I++ ++
Sbjct: 416 EKCSQELEFIEKGLKKVEEMGLAEKGDLVVLTSGVP-GKVGTTNTIRVLKV 465


>sp|P80885|KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE PROTEIN 17) (VEG17)
           >gi|7434444|pir||G69685 pyruvate kinase (EC 2.7.1.40)
           pykA - Bacillus subtilis >gi|2293265|gb|AAC00343.1|
           (AF008220) pyruvate kinase [Bacillus subtilis]
           >gi|2635383|emb|CAB14878.1| (Z99118) pyruvate kinase
           [Bacillus subtilis]
           Length = 585
           
 Score =  357 bits (906), Expect = 2e-97
 Identities = 200/477 (41%), Positives = 297/477 (61%), Gaps = 16/477 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGPA+ S  M+ KL+E+G++V RLNFSHG FEEH   I+ +R+ S+KL + V 
Sbjct: 3   KTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHGARIKNIREASKKLGKNVG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL D  G +IR   ++ G +EL+ G++++++  +VVG    I V Y+     V +G  I 
Sbjct: 63  ILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTDKISVTYEGLVHDVEQGSTIL 122

Query: 130 LSDGYIVLRVEEVRG--QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           L DG I L V +V    ++++  V++ G L ++KG+N+P   + +  +T +D   I F I
Sbjct: 123 LDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNVPGVSVNLPGITEKDARDIVFGI 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD I  SF+    DVL+++  LE+++A+D+ +I KIE  + V N D IL+ SDG+M+
Sbjct: 183 EQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGLMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E +P++QKELI+K N  GKPVITATQML SM     PTRAE +DVANAI
Sbjct: 243 ARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGTRGTI 364
            DGTDA+MLS ETA G +P++AV+ M  IA  +EE   Y+E     R      D    TI
Sbjct: 303 FDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRR------DQVGMTI 356

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
            +AI +S+      LN   I+TPT +G TAR+I++++P+  I   + N+ +   L    G
Sbjct: 357 TDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSG 416

Query: 425 VYAFCLE--EGFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           V+A   +     DE   D ++     G+V+  D++++T G  + ++  TN +K+  +
Sbjct: 417 VFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAG-TVGESGTTNLMKVHTV 472


>pir||S27330 pyruvate kinase (EC 2.7.1.40) isoform 1 - Bacillus
           stearothermophilus >gi|47828|emb|CAA40994.1| (X57859)
           pyruvate kinase [Bacillus stearothermophilus]
           Length = 494
           
 Score =  356 bits (905), Expect = 2e-97
 Identities = 206/478 (43%), Positives = 298/478 (62%), Gaps = 15/478 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGPA+ S + + +L+E G++V RLNFSHG  EEH + I  +R+ +++  R VA
Sbjct: 4   KTKIVCTIGPASESVDKLVQLMEAGMNVARLNFSHGDHEEHGRRIANIREAAKRTGRTVA 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL D  G +IR   ++ G +ELK G K+V++  +V+G    I V Y      VS G  I 
Sbjct: 64  ILLDTKGPEIRTHNMENGAIELKEGSKLVISMSEVLGTPEKISVTYPSLIDDVSVGAKIL 123

Query: 130 LSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           L DG I L V  V  Q  E V  V++GG L ++KG+N+P   + +  +T +D   I F I
Sbjct: 124 LDDGLISLEVNAVDKQAGEIVTTVLNGGVLKNKKGVNVPGVKVNLPGITEKDRADILFGI 183

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
            QG+D I  SFV    DVL+++  LE +DA  + +I+KIE  + V N DEIL+A+DG+M+
Sbjct: 184 RQGIDFIAASFVRRASDVLEIRELLEAHDALHIQIIAKIENEEGVANIDEILEAADGLMV 243

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E +P++QK LI+K N  GKPVITATQML SM     PTRAE +DVANAI
Sbjct: 244 ARGDLGVEIPAEEVPLIQKLLIKKCNMLGKPVITATQMLDSMQRNPRPTRAEASDVANAI 303

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR---GTI 364
            DGTDAVMLS ETA G++P++AVK M +IA  TE+  E       R+++   T+    TI
Sbjct: 304 FDGTDAVMLSGETAAGQYPVEAVKTMHQIALRTEQALEH------RDILSQRTKESQTTI 357

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
            +AI +S+      L++  I+TPT +G+T +++++++PK  I   ++NE V   L   +G
Sbjct: 358 TDAIGQSVAHTALNLDVAAIVTPTVSGKTPQMVAKYRPKAPIIAVTSNEAVSRRLALVWG 417

Query: 425 VY---AFCLEEGFDERDI-IRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
           VY   A  +    +  D+ +      GLV+  D+V++T G P+ +T  TN +K+  I+
Sbjct: 418 VYTKEAPHVNTTDEMLDVAVDAAVRSGLVKHGDLVVITAGVPVGETGSTNLMKVHVIS 475


>sp|Q02499|KPYK_BACST PYRUVATE KINASE (PK) >gi|421472|pir||S29783 pyruvate kinase (EC
           2.7.1.40) isoform 2 - Bacillus stearothermophilus
           >gi|285623|dbj|BAA02406.1| (D13095) pyruvate kinase
           [Bacillus stearothermophilus]
           Length = 587
           
 Score =  356 bits (905), Expect = 2e-97
 Identities = 206/478 (43%), Positives = 298/478 (62%), Gaps = 15/478 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGPA+ S + + +L+E G++V RLNFSHG  EEH + I  +R+ +++  R VA
Sbjct: 4   KTKIVCTIGPASESVDKLVQLMEAGMNVARLNFSHGDHEEHGRRIANIREAAKRTGRTVA 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL D  G +IR   ++ G +ELK G K+V++  +V+G    I V Y      VS G  I 
Sbjct: 64  ILLDTKGPEIRTHNMENGAIELKEGSKLVISMSEVLGTPEKISVTYPSLIDDVSVGAKIL 123

Query: 130 LSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           L DG I L V  V  Q  E V  V++GG L ++KG+N+P   + +  +T +D   I F I
Sbjct: 124 LDDGLISLEVNAVDKQAGEIVTTVLNGGVLKNKKGVNVPGVKVNLPGITEKDRADILFGI 183

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
            QG+D I  SFV    DVL+++  LE +DA  + +I+KIE  + V N DEIL+A+DG+M+
Sbjct: 184 RQGIDFIAASFVRRASDVLEIRELLEAHDALHIQIIAKIENEEGVANIDEILEAADGLMV 243

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E +P++QK LI+K N  GKPVITATQML SM     PTRAE +DVANAI
Sbjct: 244 ARGDLGVEIPAEEVPLIQKLLIKKCNMLGKPVITATQMLDSMQRNPRPTRAEASDVANAI 303

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR---GTI 364
            DGTDAVMLS ETA G++P++AVK M +IA  TE+  E       R+++   T+    TI
Sbjct: 304 FDGTDAVMLSGETAAGQYPVEAVKTMHQIALRTEQALEH------RDILSQRTKESQTTI 357

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
            +AI +S+      L++  I+TPT +G+T +++++++PK  I   ++NE V   L   +G
Sbjct: 358 TDAIGQSVAHTALNLDVAAIVTPTVSGKTPQMVAKYRPKAPIIAVTSNEAVSRRLALVWG 417

Query: 425 VY---AFCLEEGFDERDI-IRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
           VY   A  +    +  D+ +      GLV+  D+V++T G P+ +T  TN +K+  I+
Sbjct: 418 VYTKEAPHVNTTDEMLDVAVDAAVRSGLVKHGDLVVITAGVPVGETGSTNLMKVHVIS 475


>sp|Q55863|KPY1_SYNY3 PYRUVATE KINASE 1 (PK 1) >gi|7434447|pir||S76677 pyruvate kinase
           (EC 2.7.1.40) 1 - Synechocystis sp. (strain PCC 6803)
           >gi|1208453|dbj|BAA10621.1| (D64004) pyruvate kinase
           [Synechocystis sp.]
           Length = 483
           
 Score =  355 bits (902), Expect = 5e-97
 Identities = 203/484 (41%), Positives = 313/484 (63%), Gaps = 20/484 (4%)

Query: 4   MRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK 63
           MR   H+TKIVATIGPA+SS  +I+++++ G++V RLNFSHGS+E+HA ++  +R + Q+
Sbjct: 11  MRPLSHRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQE 70

Query: 64  LDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
           +D  + +L DL G KIR+G++ GG  +L+ GEKV L   ++ GD     V   D+P L +
Sbjct: 71  MDTPITLLQDLQGPKIRIGQLPGGEKQLREGEKVSLVPVEI-GDRHPGAVGI-DYPHLAT 128

Query: 124 K---GDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
           +   G+ I L DG + ++V  ++  +V   VV+GG L SRKG+N+P   L + ++T +D 
Sbjct: 129 EAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLPGLVLTLPSMTTKDK 188

Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
           + ++F + QG+D + LSFV    D+  +K FL +    D+ VI+KIE+P A+ N +EI+ 
Sbjct: 189 QDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVA 248

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
            S+GIM+ARGDLGVE+  E++P LQKE+IR+ N    PVITATQML SM     PTRAE 
Sbjct: 249 VSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEA 308

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRE-LVEDG 359
           +DVANAILDGTDAVMLS E+A+G++P+ +V+M+ KIA+ TE      G+  +    +E+ 
Sbjct: 309 SDVANAILDGTDAVMLSGESAVGQYPVKSVQMLRKIAEETE-----VGLHLVNNPPIENT 363

Query: 360 TRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
               + EA+   +ID +  L++KYI+T T +G T+ L S  +P   +  F+ +E+V ++L
Sbjct: 364 ETHALSEALV--VIDGI--LDLKYIVTFTTSGFTSLLASNQRPSVPVIAFTPSEKVYHSL 419

Query: 420 MFSYGVYAFCLEEGFDE-RDIIR----LIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
              +G+  F + E FD   D+I+    L++   +VE  D +L+  G P +   GTN +KI
Sbjct: 420 NLVWGIIPFLINEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKI 479

Query: 475 FQIA 478
            +I+
Sbjct: 480 HRIS 483


>gb|AAC12962.1| (U73943) pyruvate kinase I [Bacillus subtilis]
           Length = 584
           
 Score =  353 bits (896), Expect = 3e-96
 Identities = 200/477 (41%), Positives = 294/477 (60%), Gaps = 17/477 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGPA+ S  M+ KL+E+G++V RLNFSHG F+EH   I+ +R+ ++KL + V 
Sbjct: 3   KTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL D  G +IR   ++ G +EL  G K+V++  +V+G    I V Y+     V+KG  I 
Sbjct: 63  ILLDTKGPEIRTHTMENGSIELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTIL 122

Query: 130 LSDGYIVLRVEEVRG--QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           L DG I L V +V    ++++  V++ G L ++KG+N+P        +T +D   I F I
Sbjct: 123 LDDGLIGLEVLDVDAVKREIKTKVLNNGTLKNKKGVNVPGRKCQSSGITEKDARDIVFGI 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD I  SF+    DVL+++  LE+++A+D+ +I KIE  + V N D IL+ SDG+M+
Sbjct: 183 EQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGLMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E +P++QKELI+K N  GKPVITATQML SM     PTRAE +DVANAI
Sbjct: 243 ARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGTRGTI 364
            DGTDA+MLS ETA G +P++AV+ M  IA  +EE   Y+E     R      D    TI
Sbjct: 303 FDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRR------DQVGMTI 356

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
            +AI +S+      LN   I+TPT +G TAR+I++++P+  I   + N+ +   L    G
Sbjct: 357 TDAIGQSVAHTAINLNAA-IVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSG 415

Query: 425 VYAFCLE--EGFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           V+A   +     DE   D ++     G+V+  D++++T G  + ++  TN +K+  +
Sbjct: 416 VFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAG-TVGESGTTNLMKVHTV 471


>sp|P51181|KPYK_BACLI PYRUVATE KINASE (PK) >gi|1361386|pir||JC4220 pyruvate kinase (EC
           2.7.1.40) [validated] - Bacillus licheniformis
           >gi|1041099|dbj|BAA06727.1| (D31955) Pyruvate Kinase
           [Bacillus licheniformis]
           Length = 585
           
 Score =  344 bits (872), Expect = 2e-93
 Identities = 192/474 (40%), Positives = 288/474 (60%), Gaps = 10/474 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGPA+ S   + +L+E G++V RLNFSHG FEEH   I+ +R+ + KL + + 
Sbjct: 3   KTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAGKLGKDIG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL D  G +IR   ++ G +EL  G +++++  +V+G    I V Y      VS G  I 
Sbjct: 63  ILLDTKGPEIRTHTMENGSIELAAGSQLIVSMDEVIGTPDKISVTYDGLIHDVSVGSTIL 122

Query: 130 LSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           L DG + L V ++     E V  V++ G L ++KG+N+P   + +  +T +D   I F I
Sbjct: 123 LDDGLVGLEVTDINKDKREIVTKVMNSGTLKNKKGVNVPGVSVNLPGITEKDANDIVFGI 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD I  SFV    DVL+++  LE+++A D+ +I KIE  + V N D IL+ SDG+M+
Sbjct: 183 EQGVDFIAASFVRRPSDVLEIRELLEEHNAADIQIIPKIENQEGVDNIDAILEVSDGLMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E +P++QKELI+K N  GKPVITATQML SM     PTRAE +DVANAI
Sbjct: 243 ARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
            DGTDA+MLS ETA G +P++AV+ M  IA  +E   E+    ++          +I +A
Sbjct: 303 FDGTDAIMLSGETAAGNYPVEAVQTMHNIASRSE---EALNHKKILSARSKQVSMSITDA 359

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           I +S+      L++  I+TPT +G TAR+IS+++P+  I   + N+ V   L   +GV+A
Sbjct: 360 IGQSVAHTAINLDVNAIVTPTESGHTARMISKYRPQAPIVAVTVNDAVSRKLSLVFGVFA 419

Query: 428 FCLEEGFDERDIIR--LIKGL--GLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
              +      +++   + K L  G+V   D++++T G  + +   TN +K++ +
Sbjct: 420 TSGQNHSSTDEMLEKAVQKSLDTGIVRHGDLIVITAG-AVGEAGTTNLMKVYVV 472


>dbj|BAA89788.1| (AB037182) pyruvate kinase [Selenomonas ruminantium]
           Length = 470
           
 Score =  335 bits (849), Expect = 8e-91
 Identities = 186/462 (40%), Positives = 281/462 (60%), Gaps = 14/462 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T GP+T    +I  LI NG++  R NFSHG  EEH   I  VR+ ++K  + ++
Sbjct: 4   KTKIVCTQGPSTEKPGVIDALIANGMNCARFNFSHGDHEEHLGRINMVREAAKKAGKVIS 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           ++ D  G ++R+GE K G V L++G K  LT  D  GDET + V +K     V  GD + 
Sbjct: 64  LILDTKGPEMRLGEFKDGKVMLEKGNKFTLTYDDEPGDETHVSVNHKGLYTEVKPGDTLL 123

Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
           LSDG + L+V+E++G+D+   + + GK+ +RK +  P   L +  ++ +D + I F  EQ
Sbjct: 124 LSDGLVALKVDEIKGKDIVTTIQNSGKMSTRKRVAAPGVPLGLPPISEQDAKDIIFGCEQ 183

Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
            +D +  SF+    DV+ ++  +E+++   + ++ KIE  + V+NFD IL+ SDGIM+AR
Sbjct: 184 DMDFVAASFIQRPDDVIAIRKLIEEHNGH-MEILPKIENLEGVKNFDAILEVSDGIMVAR 242

Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
           GDLGVE+P E +P++QKE+IRK N  GKPVI ATQML SM     PTRAEV+DV NAILD
Sbjct: 243 GDLGVEVPAEDVPLIQKEIIRKCNAAGKPVIVATQMLDSMERNPRPTRAEVSDVGNAILD 302

Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTRGTIKE 366
           GTDA+MLS ETA G +P++AV  M +IA+  E   EY+E + + R  + +E  TR     
Sbjct: 303 GTDAIMLSGETASGDYPVEAVATMNRIAQRMESSLEYKELY-VERGLQHMESRTR----- 356

Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
           AIA + +     L+   I+TPT +G T +++S+++PK  I  ++ +E+V   L   +GVY
Sbjct: 357 AIAHATVQMAYELDAPAIITPTESGYTTKVVSKYRPKAAIVAYTPSEKVLRQLNLRWGVY 416

Query: 427 AFCLEEGFDERDIIRLIKGLG----LVESDDIVLMTEGKPIE 464
                +  D  ++I           LV+  D+ ++T G  +E
Sbjct: 417 PVLGTQWSDVDEMISNATAAAVKEDLVQRGDLTIITSGVKME 458


>sp|P51182|KPYK_BACPY PYRUVATE KINASE (PK) >gi|1363364|pir||JC4219 pyruvate kinase (EC
           2.7.1.40) - Bacillus psychrophilus
           >gi|1041097|dbj|BAA06725.1| (D31954) Pyruvate Kinase
           [Bacillus psychrophilus]
           Length = 586
           
 Score =  332 bits (842), Expect = 6e-90
 Identities = 193/480 (40%), Positives = 285/480 (59%), Gaps = 21/480 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGPA+ S  ++++LIE G++V RLNFSHG+  EH   I+ +R ++++  + V 
Sbjct: 3   KTKIVCTIGPASESPELLEQLIEAGMNVARLNFSHGNHAEHKARIDSIRKVAREKGKVVG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL D  G +IR   +  G +EL  G+K+ ++   V G+     V Y      V++G VI 
Sbjct: 63  ILLDTKGPEIRTHSMMNGKLELVTGQKIDISMTQVEGNNDVFSVSYDKLIEDVNEGSVIL 122

Query: 130 LSDGYIVLRVEEVRGQDV-----EAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK 184
           L DG I L   EV G+DV       ++++ G L + KG+NIP   + +  +T +D E I 
Sbjct: 123 LDDGLIQL---EVTGKDVARGLIHTLIINSGSLSNNKGVNIPGVSVQLPGMTEKDAEDIL 179

Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
           F I +GVD I  SFV    DV+++++ LE N+  ++ +I KIE  + V N DEIL  SDG
Sbjct: 180 FGIREGVDFIAASFVRRASDVMEIRALLENNNGSNLQIIPKIENQEGVDNIDEILNVSDG 239

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           +M+ARGDLGVE+P E +P++QK LI K N  GKPVITATQML SM     PTRAE +DVA
Sbjct: 240 LMVARGDLGVEIPPEEVPLVQKNLIEKCNQAGKPVITATQMLDSMQRNPRPTRAEASDVA 299

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTR 361
           NAI DGTDA+MLS ETA G +P+++V+ M +IA  TE   +YR S   +R RE       
Sbjct: 300 NAIFDGTDAIMLSGETAAGIYPVESVQTMDRIALTTEAAIDYR-SVVSTRRRE-----KH 353

Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMF 421
           G + EAI ++       L +K +L PT +G TA++I++++P   +   +++E     L  
Sbjct: 354 GNMTEAIGQAAAYTAINLKVKAVLAPTESGHTAKMIAKYRPGCPVIAVTSSEMCSRKLSL 413

Query: 422 SYGVYAFCLEEGFDERDIIRLIKGLGL----VESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
            +GVY    ++     +I++      +    V   D+V++T G P+ +   TN +KI  I
Sbjct: 414 IWGVYPIVGKKASSIDEILQESVEESVKHQYVGHGDVVIITAGVPVGEAGTTNLMKIHVI 473


>pir||B75251 pyruvate kinase - Deinococcus radiodurans (strain R1)
           >gi|6460464|gb|AAF12171.1|AE002092_9 (AE002092) pyruvate
           kinase [Deinococcus radiodurans]
           Length = 482
           
 Score =  332 bits (842), Expect = 6e-90
 Identities = 196/471 (41%), Positives = 286/471 (60%), Gaps = 9/471 (1%)

Query: 8   DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
           D  TKIVAT+GPA+ S  ++ ++I+ G++VVRLNFSHG  E+H + ++ VRD++      
Sbjct: 5   DRATKIVATVGPASRSTEVLGRMIDVGLNVVRLNFSHGDLEDHRQTVQMVRDLAVSKGVT 64

Query: 68  VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
           + IL DL G KIRVG    G V L  G+K V+T  +V G+   +   YK     V+ G  
Sbjct: 65  IGILQDLQGPKIRVGRFAEGSVTLNPGQKFVITMDEVEGNAERVGSTYKGLAGDVTPGMT 124

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG + LRV+ VRG D++  V+ GG L + KGIN+P+A L V A++ +D++ ++F  
Sbjct: 125 LLLDDGNMSLRVDHVRGNDIQTTVLIGGTLKNNKGINVPEADLTVPALSEKDVQDMEFGA 184

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
             GVD + LSFV S  D+L  + +L +  +    +++KIE+P AV  F +ILK  DG+M+
Sbjct: 185 SLGVDWVALSFVRSRDDLLLARHYLARFGSR-AKLMAKIEKPQAVDRFADILKEVDGVMV 243

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVEM  E++P +QK +IR     GKPVITATQML SM     PTRAE +DVANAI
Sbjct: 244 ARGDLGVEMRPEQVPTIQKRIIRMCREAGKPVITATQMLESMINLPRPTRAEASDVANAI 303

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
            DGTDAVMLS E+A G++P+++V MM +IA+  E   E + + + R++V D  +   ++A
Sbjct: 304 YDGTDAVMLSAESAAGQYPVESVAMMDRIAREAEA-SELYQLMQ-RQVVMDTEQA--QDA 359

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           IA +  +    L    I+T T TG  A  IS+ +P   I   + NE   N L  S+GVY 
Sbjct: 360 IALAACNIGAKLEAPAIVTFTSTGGAATRISKNRPPLAIVALTPNEITRNQLALSWGVYP 419

Query: 428 FCLEEGFDERDIIRL----IKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
              E+  D  D++R+    +K  GL +  D  ++T G P      TN +++
Sbjct: 420 MLSEDPEDTDDMVRIANDELKKSGLADVGDRYVITAGVPFGVRGTTNMLRV 470


>emb|CAB70653.1| (AL137242) pyruvate kinase [Streptomyces coelicolor A3(2)]
           Length = 476
           
 Score =  332 bits (842), Expect = 6e-90
 Identities = 186/472 (39%), Positives = 280/472 (58%), Gaps = 8/472 (1%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           ++KIV T+GPA  S   +  LIE G++V R NFSHG+  EH    ++VR  +++  R + 
Sbjct: 3   RSKIVCTLGPAVDSHEQLVTLIEAGMNVARFNFSHGTHAEHQGRYDRVRAAAKETGRAIG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           +LADL G KIR+     G VEL RG++  +T  DV GD T     YK  P  V+KGD + 
Sbjct: 63  VLADLQGPKIRLETFAEGPVELVRGDEFTITAEDVPGDRTICGTTYKGLPGDVTKGDQVL 122

Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
           ++DG + L+V EV G  V+ +V+ GG +   KGIN+P A + V A++ +D+E ++FA+  
Sbjct: 123 INDGNVELKVTEVEGPRVKTIVIEGGVISDHKGINLPGAAVNVPALSEKDVEDLRFALRM 182

Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
           G D + LSFV    DV  V   +++ +   V VI+K+E+P AV N ++++ A DG+M+AR
Sbjct: 183 GCDLVALSFVRDAKDVADVHRVMDE-EGRRVPVIAKVEKPQAVDNMEDVVMAFDGVMVAR 241

Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
           GDL VE P+E++P++QK LI       KPVI ATQM+ SM     PTRAE +DVANAILD
Sbjct: 242 GDLAVEYPLEKVPMVQKRLIELCRRNAKPVIVATQMMESMITNSRPTRAEASDVANAILD 301

Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
           G DAVMLS E+++G +PI+ VK M+KI    E+   S G+  L    +  T+G    ++A
Sbjct: 302 GADAVMLSAESSVGAYPIETVKTMSKIVTAAEQELLSKGLQPLVPGKKPRTQG---GSVA 358

Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
           R+  +    L  K ++  T++G TAR +SR++  Q I  F+T+E   N L  S+GV    
Sbjct: 359 RAAAEIADFLGGKGLVAFTQSGDTARRLSRYRAAQPILAFTTDESTRNQLALSWGVEPHV 418

Query: 430 LEEGFDERDIIRLI----KGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           +       +++ L+      LG     D V++T G P   +  TN +++  +
Sbjct: 419 VPFVNTTDEMVDLVDQETARLGRFSDGDTVVITAGSPPGVSGTTNMVRVLHL 470


>sp|P14178|KPY1_ECOLI PYRUVATE KINASE I (PK-1) >gi|7428041|pir||D64925 pyruvate kinase
           (EC 2.7.1.40) [validated] - Escherichia coli
           >gi|1549287|gb|AAB47952.1| (U68703) pyruvate kinase
           [Escherichia coli] >gi|1787965|gb|AAC74746.1| (AE000262)
           pyruvate kinase I (formerly F), fructose stimulated
           [Escherichia coli K12]
           Length = 470
           
 Score =  328 bits (832), Expect = 8e-89
 Identities = 187/472 (39%), Positives = 277/472 (58%), Gaps = 12/472 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S  M+ K+++ G++V+RLNFSHG + EH + I+ +R++  K  +  A
Sbjct: 3   KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++GG  V LK G+    TT + V+G+   + V Y+ F   +S G+ 
Sbjct: 63  ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG I + V  + G  V   V++ G L   KG+N+P   + + A+  +D + + F  
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV++++  L+ +  E++ +ISKIE  + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E +   QK +I K     K VITATQML SM     PTRAE  DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDGTDAVMLS E+A GK+P++AV +MA I + T+       M+   E   D  +  I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + R  ++    L+   I+  T+ G++AR + ++ P   I   +TNE+  + L+ S GV  
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417

Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
             ++E     D  RL K L    GL    D+V+M  G  +   T  T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469


>sp|Q56301|KPYK_THELI PYRUVATE KINASE (PK) >gi|2147994|pir||A57418 pyruvate kinase -
           Thermococcus litoralis (fragment)
           >gi|1016357|emb|CAA58793.1| (X83963) pyruvate kinase
           [Thermococcus litoralis]
           Length = 220
           
 Score =  327 bits (829), Expect = 2e-88
 Identities = 160/215 (74%), Positives = 187/215 (86%)

Query: 4   MRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK 63
           M LP HKTKI+ATIGPA+  +  IKK+I+ G+SV R+NFSHG+ EEHAK IE VRD+++K
Sbjct: 5   MELPSHKTKIIATIGPASKQKESIKKMIKAGMSVARINFSHGTLEEHAKTIETVRDVAEK 64

Query: 64  LDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
           L+RRVAIL DLPGLK+RVG+IKG  V L++G+KVVLTTRD+ GDETTIPVE+KD P+LVS
Sbjct: 65  LERRVAILGDLPGLKMRVGKIKGDSVTLRKGDKVVLTTRDIEGDETTIPVEFKDLPKLVS 124

Query: 124 KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           KGD IYLSDGYI+LRVEEVR  +VE VVV+GG LFS KGINIPKA LP+EA+TPRD EII
Sbjct: 125 KGDTIYLSDGYIMLRVEEVRENEVECVVVNGGILFSHKGINIPKANLPIEAITPRDFEII 184

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE 218
           +FAIE GVDAIGLSFVGSVYDVLKVKSFLEK  A+
Sbjct: 185 EFAIEHGVDAIGLSFVGSVYDVLKVKSFLEKKSAD 219


>sp|P73534|KPY2_SYNY3 PYRUVATE KINASE 2 (PK 2) >gi|7434448|pir||S77240 pyruvate kinase
           (EC 2.7.1.40) 2 - Synechocystis sp. (strain PCC 6803)
           >gi|1652654|dbj|BAA17574.1| (D90907) pyruvate kinase
           [Synechocystis sp.]
           Length = 591
           
 Score =  326 bits (828), Expect = 2e-88
 Identities = 192/420 (45%), Positives = 266/420 (62%), Gaps = 12/420 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKIVATIGPAT S+ ++++LI+ G +  RLNFSHG    H + I  +R I+ +L++ V 
Sbjct: 9   RTKIVATIGPATQSKEVLRQLIQAGATTFRLNFSHGDHAYHQQSIRLIRQIAFELNQPVG 68

Query: 70  ILADLPGLKIRVGEI--KGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL DL G KIRVG+     G V+LK G+   LT+R V   ET   + Y+     V  G  
Sbjct: 69  ILQDLQGPKIRVGKFLNDAGSVQLKNGDPYTLTSRPVECTETISSISYEYLADEVPSGAR 128

Query: 128 IYLSDGYIVLRVEEVR--GQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
           I L DG + + VEEV    +D+   V+ GG L S KG+N P   L V+A+T +D E + F
Sbjct: 129 ILLDDGKLEMLVEEVDTVARDLHCRVIVGGTLSSNKGVNFPGVCLSVKAMTDKDKEDLMF 188

Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGI 245
            ++QGVD + LSFV +  D+ ++K  +     + V VI+KIE+ +A+++   +L+  DG+
Sbjct: 189 GLDQGVDWVALSFVRNPQDIDEIKGLIAAA-GKSVPVIAKIEKHEAIKDMQAVLEKCDGV 247

Query: 246 MIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVAN 305
           M+ARGDLGVE+P E +PILQK+LI  AN  G PVITATQML SM     PTRAEV+DVAN
Sbjct: 248 MVARGDLGVELPAEDVPILQKKLIATANRLGIPVITATQMLDSMVNSPRPTRAEVSDVAN 307

Query: 306 AILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIK 365
           AILDGTDAVMLS ETAIGKFP++AV +MAKIA+  E+  E    S+      + +R +I 
Sbjct: 308 AILDGTDAVMLSNETAIGKFPVEAVAIMAKIAERIEQ--EDINPSQ-----AEASRTSIP 360

Query: 366 EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV 425
            AI+ ++     TLN   I++ T+TG TAR +S+F+PK  I   + +  V   L   +GV
Sbjct: 361 NAISSAVSQIAETLNAAAIMSLTKTGSTARHVSKFRPKTPILAVTPHVDVSRQLQLVWGV 420


>pdb|1PKY|A Chain A, Pyruvate Kinase From E. Coli In The T-State
           >gi|1310979|pdb|1PKY|B Chain B, Pyruvate Kinase From E.
           Coli In The T-State >gi|1310981|pdb|1PKY|D Chain D,
           Pyruvate Kinase From E. Coli In The T-State
           >gi|1310980|pdb|1PKY|C Chain C, Pyruvate Kinase From E.
           Coli In The T-State
           Length = 470
           
 Score =  326 bits (827), Expect = 3e-88
 Identities = 186/472 (39%), Positives = 276/472 (58%), Gaps = 12/472 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S  M+ K+++ G++V+RLNFSHG + EH + I+ +R++  K  +  A
Sbjct: 3   KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++GG  V LK G+    TT + V+G+   + V Y+ F   +S G+ 
Sbjct: 63  ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG I + V  + G  V   V++ G L   KG+N+P   + + A+  +D + + F  
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV++++  L+ +  E++ +ISKIE  + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E +   QK +I K     K VITAT ML SM     PTRAE  DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTRAEAGDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDGTDAVMLS E+A GK+P++AV +MA I + T+       M+   E   D  +  I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + R  ++    L+   I+  T+ G++AR + ++ P   I   +TNE+  + L+ S GV  
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417

Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
             ++E     D  RL K L    GL    D+V+M  G  +   T  T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469


>pdb|1E0U|A Chain A, Structure R271l Mutant Of E. Coli Pyruvate Kinase
           >gi|9955372|pdb|1E0U|B Chain B, Structure R271l Mutant
           Of E. Coli Pyruvate Kinase >gi|9955373|pdb|1E0U|C Chain
           C, Structure R271l Mutant Of E. Coli Pyruvate Kinase
           >gi|9955374|pdb|1E0U|D Chain D, Structure R271l Mutant
           Of E. Coli Pyruvate Kinase
           Length = 470
           
 Score =  325 bits (825), Expect = 5e-88
 Identities = 186/472 (39%), Positives = 276/472 (58%), Gaps = 12/472 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S  M+ K+++ G++V+RLNFSHG + EH + I+ +R++  K  +  A
Sbjct: 3   KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++GG  V LK G+    TT + V+G+   + V Y+ F   +S G+ 
Sbjct: 63  ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG I + V  + G  V   V++ G L   KG+N+P   + + A+  +D + + F  
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV++++  L+ +  E++ +ISKIE  + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E +   QK +I K     K VITAT ML SM     PTRAE  DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRALKVVITATMMLDSMIKNPRPTRAEAGDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDGTDAVMLS E+A GK+P++AV +MA I + T+       M+   E   D  +  I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + R  ++    L+   I+  T+ G++AR + ++ P   I   +TNE+  + L+ S GV  
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417

Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
             ++E     D  RL K L    GL    D+V+M  G  +   T  T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469


>pdb|1E0T|A Chain A, R292d Mutant Of E. Coli Pyruvate Kinase
           >gi|9955368|pdb|1E0T|B Chain B, R292d Mutant Of E. Coli
           Pyruvate Kinase >gi|9955369|pdb|1E0T|C Chain C, R292d
           Mutant Of E. Coli Pyruvate Kinase >gi|9955370|pdb|1E0T|D
           Chain D, R292d Mutant Of E. Coli Pyruvate Kinase
           Length = 470
           
 Score =  323 bits (820), Expect = 2e-87
 Identities = 185/472 (39%), Positives = 275/472 (58%), Gaps = 12/472 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S  M+ K+++ G++V+RLNFSHG + EH + I+ +R++  K  +  A
Sbjct: 3   KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++GG  V LK G+    TT + V+G+   + V Y+ F   +S G+ 
Sbjct: 63  ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG I + V  + G  V   V++ G L   KG+N+P   + + A+  +D + + F  
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV++++  L+ +  E++ +ISKIE  + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E +   QK +I K     K VITAT ML SM     PT AE  DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTDAEAGDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDGTDAVMLS E+A GK+P++AV +MA I + T+       M+   E   D  +  I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + R  ++    L+   I+  T+ G++AR + ++ P   I   +TNE+  + L+ S GV  
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417

Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
             ++E     D  RL K L    GL    D+V+M  G  +   T  T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469


>pir||S29004 pyruvate kinase (EC 2.7.1.40) I - Escherichia coli
           >gi|147276|gb|AAA24392.1| (M24636) pyruvate kinase I (EC
           2.7.1.40) [Escherichia coli]
           Length = 462
           
 Score =  323 bits (819), Expect = 3e-87
 Identities = 182/453 (40%), Positives = 269/453 (59%), Gaps = 11/453 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S  M+ K+++ G++V+RLNFSHG + EH + I+ +R++  K  +  A
Sbjct: 3   KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++GG  V LK G+    TT + V+G+   + V Y+ F   +S G+ 
Sbjct: 63  ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG I + V  + G  V   V++ G L   KG+N+P   + + A+  +D + + F  
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV++++  L+ +  E++ +ISKIE  + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E +   QK +I K     K VITATQML SM     PTRAE  DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDGTDAVMLS E+A GK+P++AV +MA I + T+       M+   E   D  +  I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + R  ++    L+   I+  T+ G++AR + ++ P   I   +TNE+  + L+ S GV  
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417

Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVL 456
             ++E     D  RL K L    GL    D+V+
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVV 450


>sp|P77983|KPY1_SALTY PYRUVATE KINASE I (PK-1) >gi|1526982|emb|CAA68205.1| (X99945)
           pyruvate kinase like protein [Salmonella typhimurium]
           Length = 470
           
 Score =  323 bits (818), Expect = 4e-87
 Identities = 185/472 (39%), Positives = 276/472 (58%), Gaps = 12/472 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S  M+ K+++ G++V+RLNFSHG + EH + I+ +R++  K  ++ A
Sbjct: 3   KTKIVCTIGPKTESEEMLSKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKKAA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++GG  V LK G+    TT + VVG+   + V Y+ F   +S G+ 
Sbjct: 63  ILLDTKGPEIRTIKLEGGNDVSLKAGQTFTFTTDKSVVGNNEIVAVTYEGFTSDLSVGNT 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG I + V  + G      V++ G L   KG+N+P   + + A+  +D + + F  
Sbjct: 123 VLVDDGLIGMEVTAIEGNKCICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV++++  L+ +  E++ +ISKIE  + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVVEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E +   QK +I K     K VITATQML SM     PTRAE  DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDGTDAVMLS E+A GK+P++AV +MA I + T+       M+   +   D  +  I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLDYNNDSRKLRITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + R  ++    L    I+  T+ G++AR + ++ P   I   +TNE     L+ S GV +
Sbjct: 358 VCRGAVETAEKLEAPLIVVATQGGKSARAVRKYFPDATILALTTNEVTARQLVLSKGVVS 417

Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
             ++E     D  RL K +    GL +  D+V+M  G  +   T  T S+ +
Sbjct: 418 QLVKEINSTDDFYRLGKDVALQSGLAQKGDVVVMVSGALVPSGTTNTASVHV 469


>dbj|BAA89378.1| (AB025342) ORF4 [Moritella marina]
           Length = 470
           
 Score =  318 bits (807), Expect = 7e-86
 Identities = 186/475 (39%), Positives = 277/475 (58%), Gaps = 14/475 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S   + +L+  G++V+RLNFSHG+F EH+  I+ +R +S+ L++++A
Sbjct: 3   KTKIVCTIGPKTESVEKLTELVNAGMNVMRLNFSHGNFAEHSVRIQNIRQVSENLNKKIA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           +L D  G +IR  +++ G  V L  G+    TT  +VVG++  + V Y  F + ++ G +
Sbjct: 63  VLLDTKGPEIRTIKLENGDDVMLTAGQSFTFTTDINVVGNKDCVAVTYAGFAKDLNPGAI 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           I + DG I + V      +V+  V++ G L   KG+N+P   + + A++ +D   + F  
Sbjct: 123 ILVDDGLIEMEVVATTDTEVKCTVLNTGALGENKGVNLPNISVGLPALSEKDKADLAFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQ VD +  SF+    DV +++  L  N  E++ +ISKIE  + V NFDEIL  SDGIM+
Sbjct: 183 EQEVDFVAASFIRKADDVREIREILFNNGGENIQIISKIENQEGVDNFDEILAESDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E + + QK +I+K N  GK VITATQML SM +   PTRAE  DVANA+
Sbjct: 243 ARGDLGVEIPVEEVIMAQKMMIKKCNKAGKVVITATQMLDSMISNPRPTRAEAGDVANAV 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDGTDAVMLS ETA GK+P++AV +MA I + T+    S        +V    R  I EA
Sbjct: 303 LDGTDAVMLSGETAKGKYPVEAVSIMANICERTD---NSMSSDLGANIVAKSMR--ITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + +  ++    L    I+  TR G++A+ + ++ PK  I   +TNE+    L  + GV +
Sbjct: 358 VCKGAVETTEKLCAPLIVVATRGGKSAKSVRKYFPKANILAITTNEKAAQQLCLTKGV-S 416

Query: 428 FCLEEGFDERDII-----RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
            C+ E  D  D        L    GL +  DIV+M  G  +     TN+  + Q+
Sbjct: 417 SCIVEQIDSTDEFYRKGKELALATGLAKEGDIVVMVSGALVPSGT-TNTASVHQL 470


>pir||F81382 pyruvate kinase (EC 2.7.1.40) Cj0392c [imported] - Campylobacter
           jejuni (strain NCTC 11168) >gi|6967866|emb|CAB74228.1|
           (AL139075) pyruvate kinase [Campylobacter jejuni]
           Length = 480
           
 Score =  314 bits (797), Expect = 1e-84
 Identities = 182/475 (38%), Positives = 284/475 (59%), Gaps = 19/475 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIVAT+GPA+    +++++I NGV+V RLNFSHG+ E H K ++ +R ++++L  R+ 
Sbjct: 4   KTKIVATVGPASEKEEILRQMIINGVNVFRLNFSHGTHEYHKKNLDTIRRVAKELHTRIG 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT-----IPVEYKDFPRLVSK 124
           IL D+ G KIR GE+K  + ELK+G+++      ++G++       I +  K    ++  
Sbjct: 64  ILQDISGPKIRTGELKEPF-ELKKGDRLDFYRETILGEKIAQNHYKISINQKSILDMLKI 122

Query: 125 GDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK 184
            + IYL DG I  +V  +  Q +E ++ + G L S KGIN P   + ++ +T +D   + 
Sbjct: 123 DEYIYLYDGSIRAKVVNIDNQKIETIIENDGFLNSNKGINFPNTKINIDVITQKDKNDLL 182

Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
           + I+  VD + +SFV + +D+ +V+  L +N+A+ + + +KIE+ DAV N DEI+K+SDG
Sbjct: 183 WGIKNEVDFLAISFVQNAHDIDEVREILAQNNAK-ISIFAKIEKFDAVENIDEIIKSSDG 241

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           IM+ARGDLG+E+P  ++P +QKE+I+KAN   KPVITATQML S+   K  TRAE++DVA
Sbjct: 242 IMVARGDLGIEVPYYKVPNIQKEIIQKANNASKPVITATQMLFSLAKSKTATRAEISDVA 301

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
           NA+LDGTDAVMLSEE+A+G  P +AV +M +    TE+       +   +L  D T    
Sbjct: 302 NAVLDGTDAVMLSEESAVGIDPANAVDIMCQTIIETEKRYPYNKFNDFNDL--DNT---- 355

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
            + I RS       LN   I + T +G++A  I+R++P   I     +E+  N+L   +G
Sbjct: 356 -DKIMRSSAHLATDLNADAIFSLTSSGKSAIKIARYRPNIEIIAVGHSEKTLNSLSIVWG 414

Query: 425 VYAFCLEEGFDE-----RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
           V    L    +E     +D +R     G ++ D   L+T G P      +N I+I
Sbjct: 415 VNPAILVNKSNELTELLKDSVRSSVEKGFMDEDKCYLLTAGFPTGVEGTSNLIRI 469


>pir||T35759 pyruvate kinase - Streptomyces coelicolor
           >gi|5689907|emb|CAB52070.1| (AL109732) pyruvate kinase
           [Streptomyces coelicolor A3(2)]
           Length = 478
           
 Score =  310 bits (785), Expect = 3e-83
 Identities = 181/474 (38%), Positives = 272/474 (57%), Gaps = 11/474 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           + KIV T+GPAT S + IK L++ G+ + R NFSHG+  EH +   +VR  S +  R V 
Sbjct: 3   RAKIVCTLGPATDSYDQIKDLVDAGMDIARFNFSHGTHAEHEERYHRVRKASDETGRSVG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRD-VVGDETTIPVEYKDFPRLVSKGDVI 128
            LADL G KIR+G    G V L+RG+   +T  + V GD       Y      V+ G+ +
Sbjct: 63  ALADLQGPKIRLGHFGEGPVLLERGDSFTITVEEGVEGDRYICGTTYAGLAEDVTPGERV 122

Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
            + DG + L V  V G  V   V+ GG +   KG+N+P   + V A++ +D + +++A+ 
Sbjct: 123 LVDDGKVCLEVTGVDGTRVRTRVIEGGMVSDHKGLNLPGVAVSVPALSKKDEDDLRWALR 182

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
            G D + LSFV S  D+L V   +++ +   + VI+K+E+P AV N ++I+ A DGIM+A
Sbjct: 183 AGFDVVALSFVRSGRDILDVHRIMDE-EGRRLPVIAKVEKPQAVENIEDIVAAFDGIMVA 241

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLGVEMP+E++P +QK  ++ A    KPVI ATQML SM     PTRAE +DVANA++
Sbjct: 242 RGDLGVEMPLEQVPTVQKRAVKLAKRNAKPVIVATQMLDSMIDNARPTRAEASDVANAVI 301

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           DGTDAVMLS ET++GK P D V+ MA+I +  EE   + G+  L E  +  T+G    A+
Sbjct: 302 DGTDAVMLSGETSVGKHPTDTVRTMARIVEAAEEDILAKGLPPLTERNKPRTQG---GAV 358

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
           AR+  +    L  K+++  T++G T R +SR++    +  F+      + L  ++GV  F
Sbjct: 359 ARAAAEMGDFLGAKFLVAFTQSGDTVRRLSRYRSPIPLLAFTPEPATRSQLSLTWGVETF 418

Query: 429 CLEEGFDERD-----IIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
            L    D  D     +  L+   G  E  D+V++T G P   +  TN +++  I
Sbjct: 419 -LGPHADSTDAMVDQVDELLTRYGRCEKGDVVVITAGSPPGVSGTTNLVRVHHI 471


>pir||C82316 pyruvate kinase I VC0485 [imported] - Vibrio cholerae (group O1
           strain N16961) >gi|9654913|gb|AAF93658.1| (AE004135)
           pyruvate kinase I [Vibrio cholerae]
           Length = 470
           
 Score =  303 bits (767), Expect = 3e-81
 Identities = 186/475 (39%), Positives = 273/475 (57%), Gaps = 18/475 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S   + +L+  G++V+RLNFSHG + EH   I   R + +   +++A
Sbjct: 3   KTKIVCTIGPKTESVEKLTELVNAGMNVMRLNFSHGDYVEHGTRITNFRKVMEVTGKQLA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++ G  V+L  G++   TT   VVG++  + V Y  F + ++ G+ 
Sbjct: 63  ILLDTKGPEIRTIKLENGDDVDLVAGQEFTFTTDTKVVGNKERVAVTYSGFAKDLNVGNR 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           I + DG I + V      +V+  V++ G L   KG+N+P   + + A++ +D   +KF  
Sbjct: 123 ILVDDGLIEMEVLATTDTEVKCKVLNNGALGENKGVNLPGVSVNLPALSEKDKNDLKFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV +++  L  +  +++ +ISKIE  + + NFDEIL+ SDGIM+
Sbjct: 183 EQGVDFVAASFIRKGSDVKEIREVLASHGGQNIQIISKIENQEGLDNFDEILELSDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E +   QK +I K N   K VITATQML SM     PTRAE  DVANAI
Sbjct: 243 ARGDLGVEIPAEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           +DGTDAVMLS ETA GK+P++AVK+MA+IA+ T+   ++   SRL     D  R  I EA
Sbjct: 303 MDGTDAVMLSGETAKGKYPVEAVKIMAQIAERTDPVLKAELGSRL-----DSPRLRITEA 357

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           + +  +D    L    I+  T  G++AR + ++ P   I   +TN++    L+ S GV  
Sbjct: 358 VCKGAVDTAEKLAAPLIIVATEAGKSARSVRKYFPTANIIAVTTNKKTAAQLVLSKGVTP 417

Query: 428 FCLEEGFDERDI-------IRLIKGLGLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
             + +  D  D        I L  GLG  +  DIV+M  G  +   T  T S+ +
Sbjct: 418 VVV-DAIDNTDAFYHLGKEIALQSGLG--KKGDIVVMVSGALVASGTTNTASVHV 469


>sp|Q92122|KPYK_XENLA PYRUVATE KINASE, MUSCLE ISOZYME (CYTOSOLIC THYROID HORMONE BINDING
           PROTEIN) (CTHBP) >gi|1085221|pir||S51374 pyruvate kinase
           (EC 2.7.1.40), muscle - clawed frog
           >gi|433355|gb|AAA63581.1| (U03878) cytosolic thyroid
           hormone binding protein/pyruvate kinase type M2 [Xenopus
           laevis]
           Length = 527
           
 Score =  301 bits (763), Expect = 1e-80
 Identities = 184/476 (38%), Positives = 280/476 (58%), Gaps = 32/476 (6%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ TIGPA+ S  M+K++I++G+++ RLNFSHG+ E HA  I+ VR+ ++ L      
Sbjct: 41  TGIICTIGPASRSVEMLKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESLASNPIH 100

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  D      DE  + V+YK+ 
Sbjct: 101 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATMRITLDDAFQENCDENVLWVDYKNL 160

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L V+E+        + +GG L S+KG+N+P A + + AV+ +
Sbjct: 161 TKVVKPGSKIYVDDGLISLLVKEIGPDFCVTEIENGGMLGSKKGVNLPGAAVDLPAVSSK 220

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ ++F +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 221 DIQDLQFGVEQDVDMVFASFIRKAADVHEVREVLGEK-GKNIKIISKIENHEGVRRFDEI 279

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 280 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 339

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    +R+ F  + R+  
Sbjct: 340 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQLFEELRRVSP 399

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     EA A   ++A    +   I+  T++GR+A L+SR++P+  I   + N +
Sbjct: 400 LTRDPT-----EATAVGAVEASFKCSSGAIIVLTKSGRSAHLLSRYRPRAPIISVTRNGQ 454

Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                    G++     E   E    D+       + + K  G  +S D+V++  G
Sbjct: 455 TARQAHLYRGIFPVLYREAVHEAWAEDVDSRVNFAMDIGKARGFFKSGDVVIVLTG 510


>pir||T27928 hypothetical protein ZK593.1 - Caenorhabditis elegans
           >gi|5824898|emb|CAA93424.2| (Z69385) Similarity to
           Chicken pyruvate kinase (SW:KPYK_CHICK), contains
           similarity to Pfam domain: PF00224 (Pyruvate kinase),
           Score=937.4, E-value=1.3e-278, N=1~cDNA EST EMBL:T01521
           comes from this gene~cDNA EST yk175h9.5 comes from this
           gene~cDNA EST>
           Length = 515
           
 Score =  300 bits (760), Expect = 2e-80
 Identities = 178/467 (38%), Positives = 265/467 (56%), Gaps = 19/467 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KT ++ TIGPA S    ++K+I  G+++ RLNFSHG+ E HA  I+ +R+ ++     VA
Sbjct: 35  KTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVA 94

Query: 70  ILADLPGLKIRVGEIKGGY--VELKRGEKVVLTT---RDVVGDETTIPVEYKDFPRLVSK 124
           I  D  G +IR G        V+L+ G+ V ++T    +     + I  +Y++ P++V  
Sbjct: 95  IALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQP 154

Query: 125 GDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK 184
           G  IY+ DG I L VE      V   + +GG L +RKG+N+P   + + AVT +D+E + 
Sbjct: 155 GSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 214

Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
           F +EQGVD I  SF+ +   + K++  L +   + +++I+KIE  D V N DEI++ASDG
Sbjct: 215 FGVEQGVDIIFASFIRNADGIHKIRQVLGEK-GKHIYIIAKIESEDGVTNCDEIIEASDG 273

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           +M+ARGDLG+E+P E++ + QK LI K N  GKPVI ATQML SM  +  PTRAE +DVA
Sbjct: 274 VMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVA 333

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT- 363
           NA+LDG D VMLS ETA G +P++A+ +M  I K  E     F M    EL+    + T 
Sbjct: 334 NAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAES--AFFHMKHFEELILHTKKPTG 391

Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
           +    A + + A  T     I+  T TG+TARL SR++P   I   S +ER+   L    
Sbjct: 392 MTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHR 451

Query: 424 GVYAFCLEEG-FDERDI---------IRLIKGLGLVESDDIVLMTEG 460
           G++     +G  DE D+         + L K  G +   D +++  G
Sbjct: 452 GIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITG 498


>pir||D83459 pyruvate kinase I PA1498 [imported] - Pseudomonas aeruginosa
           (strain PAO1) >gi|9947453|gb|AAG04887.1|AE004578_9
           (AE004578) pyruvate kinase I [Pseudomonas aeruginosa]
           Length = 477
           
 Score =  298 bits (756), Expect = 7e-80
 Identities = 174/478 (36%), Positives = 267/478 (55%), Gaps = 17/478 (3%)

Query: 8   DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
           D K KI+AT+GPAT SR+ I+ L+E G +++RLNFSHG + +HA+    VR++  +L+  
Sbjct: 4   DKKAKILATLGPATRSRDDIRALVEAGANLLRLNFSHGDYADHAQRFAWVREVEAELNYP 63

Query: 68  VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
           + +L DL G K+RVG    G V+L+RG+   L   D  GDE  + + + +    +  G  
Sbjct: 64  IGVLMDLQGPKLRVGRFAAGAVQLQRGQTFTLDLSDAPGDERRVNLPHPEIIHALEPGMS 123

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG I L V       +E  V  GG+L  RKG+N+P+A L +  +T +D   + F +
Sbjct: 124 LLLDDGKIRLEVVNCHSDAIETRVAVGGELSDRKGVNVPEAVLQLSPLTDKDRRDLAFGL 183

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           E GVD + LSFV    D+ + +  +     +  F+++KIE+P AV   + I + +D IM+
Sbjct: 184 ELGVDWVALSFVQRPEDIDEARGLI----GDKAFLMAKIEKPSAVSAIEAIAERADAIMV 239

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E +P +QK +++     GKPV+ ATQML SM     PTRAEVTDVA A+
Sbjct: 240 ARGDLGVEVPAESVPGIQKRIVQVCRQLGKPVVVATQMLESMRFSPAPTRAEVTDVATAV 299

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTRGTI 364
             G DAVMLS ETA G++P +AV+MMAKI +  E   +Y     ++R +         T+
Sbjct: 300 GAGADAVMLSAETASGQYPREAVEMMAKIVRQVEAEPDYHVQLEVNRPQ------PDATV 353

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
            +AI+ +I      L +  ++  T +G +    +R +PK  I   + N R    L  ++G
Sbjct: 354 SDAISCAIRRVSRILPVAVLVNYTESGNSTLRAARERPKAPILSLTPNLRTARRLTVAWG 413

Query: 425 VYAFCLEEGFDERDIIRLIKGLGLVE----SDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
           VY+   E+     +I      + L +      D V++T G P  +   TN ++I  +A
Sbjct: 414 VYSVVNEQLAHVDEICSTALDIALAQRMARRGDTVVVTAGVPFGRPGSTNMLRIETVA 471


>sp|P21599|KPY2_ECOLI PYRUVATE KINASE II (PK-2) >gi|321866|pir||S29790 pyruvate kinase
           (EC 2.7.1.40) A - Escherichia coli
           >gi|147459|gb|AAA24473.1| (M63703) pyruvate kinase type
           II [Escherichia coli] >gi|1736497|dbj|BAA15662.1|
           (D90828) Pyruvate kinase (EC 2.7.1.40) [Escherichia
           coli] >gi|1788160|gb|AAC74924.1| (AE000279) pyruvate
           kinase II, glucose stimulated [Escherichia coli K12]
           Length = 480
           
 Score =  295 bits (747), Expect = 8e-79
 Identities = 195/478 (40%), Positives = 271/478 (55%), Gaps = 15/478 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKIV T+GPAT   N ++K+I  G +VVR+NFSHGS E+H    +KVR+I+ KL R VA
Sbjct: 7   RTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVA 66

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDV 127
           IL DL G KIRV   K G V L  G+K +L        GD+  + ++YK  P  V  GD+
Sbjct: 67  ILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDI 126

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG + L+V EV+G  V   V  GG L + KGIN     L  EA+T +D   IK A 
Sbjct: 127 LLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIKTAA 186

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
             GVD + +SF     D L     L ++   D  +++K+ER +AV +    D+I+ ASD 
Sbjct: 187 LIGVDYLAVSFPRCGED-LNYARRLARDAGCDAKIVAKVERAEAVCSQDAMDDIILASDV 245

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           +M+ARGDLGVE+    L  +QK LIR+A    + VITATQM+ SM    +PTRAEV DVA
Sbjct: 246 VMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVA 305

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
           NA+LDGTDAVMLS ETA G++P + V  MA++    E+   S  +S+ R    D     +
Sbjct: 306 NAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKI-PSINVSKHR---LDVQFDNV 361

Query: 365 KEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
           +EAIA S + A   L  +  I+T T +GRTA + SR      IF  S +ER  N      
Sbjct: 362 EEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYR 421

Query: 424 GVYAFCLEEGFD----ERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           GV     +   D      + + L++  G + S D+V++T+G  +     TN+ +I  +
Sbjct: 422 GVTPVHFDSANDGVAAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTV 479


>sp|O44006|KPYK_EIMTE PYRUVATE KINASE (PK) >gi|2854033|gb|AAC02529.1| (AF043910) pyruvate
           kinase [Eimeria tenella]
           Length = 531
           
 Score =  294 bits (746), Expect = 1e-78
 Identities = 180/480 (37%), Positives = 279/480 (57%), Gaps = 16/480 (3%)

Query: 9   HKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRD-ISQKLDRR 67
           H+TKIV T+GP+    + + +LI+ G++V RLNFSHG  E H +V++ +++ + Q+  +R
Sbjct: 56  HRTKIVCTMGPSCWDVDKMVQLIDAGMNVCRLNFSHGDHEAHGRVVKNLQEALKQRPGKR 115

Query: 68  VAILADLPGLKIRVGEIKGGY-VELKRGEKV-VLTTRDVVGDETTIPVEYKDFPRLVSKG 125
           VA+L D  G +IR G ++G   +EL  G+ + ++T    VG+++ I   Y+  P  V  G
Sbjct: 116 VALLLDTKGPEIRTGMLEGDKPIELHAGDMLKIVTDYSFVGNKSCIACSYEKLPSSVKPG 175

Query: 126 DVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM-EIIK 184
           + I ++DG + + V E     V   V++   + ++K +N+P   + +  +  +D  +I+ 
Sbjct: 176 NTILIADGSLSVEVVECGKDYVMTRVMNPAIIGNKKNMNLPGVKVDLPVIGEKDKNDILN 235

Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
           F I  G + I  SFV S  DV  ++S L      ++ +I KIE  + + NFDEIL+ +DG
Sbjct: 236 FGIPMGCNFIAASFVQSADDVRYIRSILGTK-GRNIKIIPKIENVEGLLNFDEILQEADG 294

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           IMIARGDLG+E+P E++ + QK +I K N  GKPVITATQML SMT    PTRAE  DVA
Sbjct: 295 IMIARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMTKNPRPTRAEAADVA 354

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTR 361
           NA+LDGTD VMLS ETA G FP+ AV +M+++    E   +Y++ F  +    +    T 
Sbjct: 355 NAVLDGTDCVMLSGETANGSFPVQAVTVMSRVCFEAEGCIDYQQVFRATCQATMTPIDT- 413

Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMF 421
              +EA+AR+ ++   ++N   IL  T TGRTARLI++++P Q I   S +E     L  
Sbjct: 414 ---QEAVARAAVETAQSINASLILALTETGRTARLIAKYRPMQPILALSASEETIKQLQV 470

Query: 422 SYGVYAFCLE--EGFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
             GV  F +   +G D+  R+ +   K L LV   D ++   G   E    +N +K+  +
Sbjct: 471 IRGVTTFLVPTFQGTDQLIRNALSAAKELQLVSEGDSIVAVHGIKEEVAGWSNLLKVLVV 530


>sp|Q44473|KPY4_AGRVI PYRUVATE KINASE (PK) >gi|805294|gb|AAA68700.1| (U25634) putative
           pyruvate kinase; inducible by tartrate; Method:
           conceptual translation supplied by author [Agrobacterium
           vitis] >gi|1585265|prf||2124372E ttuE gene
           [Agrobacterium vitis]
           Length = 482
           
 Score =  294 bits (746), Expect = 1e-78
 Identities = 171/476 (35%), Positives = 275/476 (56%), Gaps = 12/476 (2%)

Query: 8   DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
           + ++KIVAT+GPA+SS +M++ L   GV   RLNFSHG+  +HA+V   +R + Q+ D  
Sbjct: 6   NRRSKIVATVGPASSSPDMLRSLFLAGVDTFRLNFSHGARADHAEVYRNIRALEQEHDAA 65

Query: 68  VAILADLPGLKIRVGEIKGGYVELKRGEKV-VLTTRDVVGDETTIPVEYKDFPRLVSKGD 126
           +A+L DL G KIR+G +  G ++L RG  +  +  R+       IP+ +++   +   G 
Sbjct: 66  IAVLQDLQGPKIRIGVLAHGRLDLARGSTIGFILGREGGEGMNDIPLPHREIFEVAVPGM 125

Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
            + + DG I +R+ EV    +   V++GG L +RKG+N+P A L +  +T +D E ++F 
Sbjct: 126 DLLIDDGRIKVRIMEVMDGRLVCEVLNGGALSNRKGVNVPGAVLDISPLTAKDREDLEFG 185

Query: 187 IEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIM 246
           +E GVD + LSFV    D+++ +S +     +   +I+KIE+P A+ + ++I++ SD +M
Sbjct: 186 LELGVDWVALSFVQRARDMIEARSLV----GDRAGLIAKIEKPSALDDIEDIVRLSDSVM 241

Query: 247 IARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANA 306
           +ARGDLGVE+P E +P  QKE+IR      KPVI ATQML SM +   PTRAE +DVA A
Sbjct: 242 VARGDLGVEIPPEDVPGKQKEIIRACRLAAKPVIVATQMLDSMVSSPTPTRAEASDVAGA 301

Query: 307 ILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
           I DG DAVMLS ETA G +P++AV++M +I + TE+++       + E  E     +   
Sbjct: 302 IYDGADAVMLSAETATGAYPVEAVEIMNRIIEKTEKHKH---YRPILEATEPDVAQSPPH 358

Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
           A+A +  +    L    ++  T +G TA  ISR +P   I   + +E+V   L   +GV 
Sbjct: 359 AVATAAANVAVALGSPVVVAYTSSGTTAARISRARPALPILALTPSEQVARRLNMFWGVV 418

Query: 427 AFCLEEGFD-ERDII---RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
               ++    E  +I   + ++   L    D +++  G P  +   TN++++ QIA
Sbjct: 419 GVRSQDVHTYEASLIHAQQAVQEAKLASPSDHIVIVAGFPFAQQGSTNNLRVVQIA 474


>sp|Q46078|KPYK_CORGL PYRUVATE KINASE (PK) >gi|2127424|pir||I40840 pyruvate kinase (EC
           2.7.1.40) - Corynebacterium glutamicum
           >gi|598097|gb|AAA56793.1| (L27126) pyruvate kinase
           [Corynebacterium glutamicum]
           Length = 475
           
 Score =  293 bits (743), Expect = 2e-78
 Identities = 175/471 (37%), Positives = 266/471 (56%), Gaps = 13/471 (2%)

Query: 8   DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
           D +TKIV T+GPA +S + I +L+E+G+ V RLNFSHG   +H +  + VR+ ++K  R 
Sbjct: 2   DRRTKIVCTLGPAVASADGILRLVEDGMDVARLNFSHGDHPDHEQNYKWVREAAEKTGRA 61

Query: 68  VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
           V ILADL G KIR+G    G    + GE + +T  DV G    +   YK+  +    GD 
Sbjct: 62  VGILADLQGPKIRLGRFTDGATVWENGETIRITVDDVEGTHDRVSTTYKNLAKDAKPGDR 121

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG + L    V G DV   VV GG + + KG+++P   + V A++ +D+  ++FA+
Sbjct: 122 LLVDDGKVGLVCVSVEGNDVICEVVEGGPVSNNKGVSLPGMDISVPALSEKDIRDLRFAL 181

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           + GVD I LSFV S  D   V   +++ +   V VI+K+E+P+AV + + I+ A D +M+
Sbjct: 182 KLGVDFIALSFVRSPADAELVHKIMDE-EGRRVPVIAKLEKPEAVTSLEPIVLAFDAVMV 240

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P+E +P++QK  I+ A    KPVI ATQML SM     PTRAE +DVANA+
Sbjct: 241 ARGDLGVEVPLEEVPLVQKRAIQIARENAKPVIVATQMLDSMIENSRPTRAEASDVANAV 300

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
           LDG DAVMLS ET++GK P + V+ M++I +  E         R+ +L       T +  
Sbjct: 301 LDGADAVMLSGETSVGKDPHNVVRTMSRIVRFAET------DGRVPDLTH--IPRTKRGV 352

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           I+ S  D    LN + ++  T +G TA+ ++R      +  F+ NE V + L  ++G   
Sbjct: 353 ISYSARDIAERLNARALVAFTTSGDTAKRVARLHSHLPLLVFTPNEAVRSELALTWGATT 412

Query: 428 FCLEEGFDE----RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
           F      D     R++ R +  +      D++++  G P   T  TN I +
Sbjct: 413 FLCPPVSDTDDMMREVDRALLAMPEYNKGDMMVVVAGSPPGVTGNTNMIHV 463


>sp|Q29536|KPYR_CANFA PYRUVATE KINASE, ISOZYME R >gi|7579924|gb|AAB31627.2| (S71530)
           R-type pyruvate kinase; R-type PK [Canis familiaris]
           Length = 519
           
 Score =  293 bits (743), Expect = 2e-78
 Identities = 172/438 (39%), Positives = 262/438 (59%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  +R+  +        
Sbjct: 33  TSIIATIGPASHSVERLKEMIKAGMNIARLNFSHGSHEYHAQSIANIREAVESFATSPLG 92

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDV---VGDETTIPVEYKDF 118
            R VAI  D  G +IR G +KGG    VEL +G  V++T       +GD  T+ V+Y + 
Sbjct: 93  YRPVAIALDTKGPEIRTGVLKGGPETEVELVKGSWVLVTVDPAFRTLGDAHTVWVDYPNI 152

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  I++ DG I L+V+++  + +E  V +GG L SRKG+N+P A + +  ++ +
Sbjct: 153 VKVVPVGGRIFIDDGLISLQVKKIDRKGLETQVENGGLLGSRKGVNLPGAEVDLPGLSEQ 212

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D + ++F +E  VD +  SFV    DV  +++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 213 DAQDLRFGVEHNVDIVFASFVRKASDVAAIRAALGP-EGRTIKIISKIENHEGVKKFDEI 271

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 272 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 331

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA GKFP++AVKM  +IA+  E    +R+ F  + R   
Sbjct: 332 ETSDVANAVLDGADCIMLSGETAKGKFPVEAVKMQHRIAREAEAAVYHRQLFEELRRAAP 391

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A + ++A        I+  T+TGR+A+L+SR++P+  +   + + +
Sbjct: 392 LSRDPT-----EVTAIATVEAAFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQ 446

Query: 415 VCNNLMFSYGVYAFCLEE 432
                    GV+     E
Sbjct: 447 AARQAHLCRGVFPLLYSE 464


>gb|AAA60104.1| (M15465) pyruvate kinase [Homo sapiens]
           Length = 543
           
 Score =  292 bits (740), Expect = 5e-78
 Identities = 173/438 (39%), Positives = 259/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  VR+  +        
Sbjct: 57  TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAETIANVREAVESFAGSPLS 116

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VEL +G +V++T        G+  T+ V+Y + 
Sbjct: 117 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 176

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V  G  IY+ DG I L V+++  + +   V +GG L SRKG+N+P A + +  ++ +
Sbjct: 177 VRVVPVGGRIYIDDGLISLVVQKISPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 236

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E GVD +  SFV    DV  V++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 237 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 295

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 355

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM  +IA+  E    +R+ F  + R   
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHRIAREAEAAVYHRQLFEELRRAAP 415

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T TGR+A+L+SR++P+  +   + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 470

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +    GV+     E
Sbjct: 471 AARQVHLCRGVFPLLYRE 488


>pir||T21360 hypothetical protein F25H5.3b - Caenorhabditis elegans
           >gi|3876398|emb|CAB02983.1| (Z81068) contains similarity
           to Pfam domain: PF00224 (Pyruvate kinase), Score=974.5,
           E-value=8.3e-290, N=1~cDNA EST yk206a12.5 comes from
           this gene~cDNA EST yk437b7.5 comes from this gene~cDNA
           EST yk505a11.5 comes from this gene~cDNA EST yk508d4.5
           come>
           Length = 600
           
 Score =  292 bits (740), Expect = 5e-78
 Identities = 180/429 (41%), Positives = 257/429 (58%), Gaps = 18/429 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
           +T I+ TIGPA +S  M++KLI NG+++ RLNFSHGS E HA  I  VR+ +    D+RV
Sbjct: 117 QTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKRV 176

Query: 69  -AILADLPGLKIRVGEIKGGY---VELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRL 121
             I  D  G +IR G + GG    +EL RG  + LTT     +  T   + V+YK+  ++
Sbjct: 177 IGIALDTKGPEIRTGLLAGGASAEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKV 236

Query: 122 VSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
           +S G  +Y+ DG I L VEE++   V   V +GG L SRKG+N+P   + + AV+ +D +
Sbjct: 237 LSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCK 296

Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
            ++F +EQGVD I  SF+ +   +  ++  L +   + + +I+KIE  + V N DEI+  
Sbjct: 297 DLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEK-GKKIKIIAKIENQEGVDNADEIISE 355

Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
           SDG+M+ARGDLG+E+P E++ + QK LI K N  GKPVI ATQML SM  +  PTRAE +
Sbjct: 356 SDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGS 415

Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVED 358
           DVANA+LDG D VMLS ETA G++P+DA+K+M  I K  E    +R  F      EL+++
Sbjct: 416 DVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFD-----ELLQN 470

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
             + T +   IA +   A  + +   IL  T TGR+A   SR+KP   I   S +  VC 
Sbjct: 471 TQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCR 530

Query: 418 NLMFSYGVY 426
            L    GV+
Sbjct: 531 QLHLYRGVF 539


>pir||T21361 hypothetical protein F25H5.3a - Caenorhabditis elegans
           >gi|3876399|emb|CAB02984.1| (Z81068) contains similarity
           to Pfam domain: PF00224 (Pyruvate kinase), Score=974.5,
           E-value=8.3e-290, N=1~cDNA EST EMBL:Z14697 comes from
           this gene~cDNA EST EMBL:Z14403 comes from this gene~cDNA
           EST yk38f5.3 comes from this gene~cDNA EST yk44e6.3
           come>
           Length = 562
           
 Score =  292 bits (740), Expect = 5e-78
 Identities = 180/429 (41%), Positives = 257/429 (58%), Gaps = 18/429 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
           +T I+ TIGPA +S  M++KLI NG+++ RLNFSHGS E HA  I  VR+ +    D+RV
Sbjct: 79  QTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKRV 138

Query: 69  -AILADLPGLKIRVGEIKGGY---VELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRL 121
             I  D  G +IR G + GG    +EL RG  + LTT     +  T   + V+YK+  ++
Sbjct: 139 IGIALDTKGPEIRTGLLAGGASAEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKV 198

Query: 122 VSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
           +S G  +Y+ DG I L VEE++   V   V +GG L SRKG+N+P   + + AV+ +D +
Sbjct: 199 LSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCK 258

Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
            ++F +EQGVD I  SF+ +   +  ++  L +   + + +I+KIE  + V N DEI+  
Sbjct: 259 DLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEK-GKKIKIIAKIENQEGVDNADEIISE 317

Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
           SDG+M+ARGDLG+E+P E++ + QK LI K N  GKPVI ATQML SM  +  PTRAE +
Sbjct: 318 SDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGS 377

Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVED 358
           DVANA+LDG D VMLS ETA G++P+DA+K+M  I K  E    +R  F      EL+++
Sbjct: 378 DVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFD-----ELLQN 432

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
             + T +   IA +   A  + +   IL  T TGR+A   SR+KP   I   S +  VC 
Sbjct: 433 TQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCR 492

Query: 418 NLMFSYGVY 426
            L    GV+
Sbjct: 493 QLHLYRGVF 501


>pir||B82130 pyruvate kinase II VC2008 [imported] - Vibrio cholerae  (group O1
           strain N16961) >gi|9656551|gb|AAF95156.1| (AE004275)
           pyruvate kinase II [Vibrio cholerae]
           Length = 481
           
 Score =  292 bits (740), Expect = 5e-78
 Identities = 187/480 (38%), Positives = 275/480 (56%), Gaps = 18/480 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKIVAT+GP+T S  +++ +I  G +VVR+NFSHG+ E+H    +KVR+I+ KL R VA
Sbjct: 7   RTKIVATLGPSTESPEILEAIIRAGANVVRMNFSHGTAEDHKNRAQKVREIAAKLGRHVA 66

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET--TIPVEYKDFPRLVSKGDV 127
           +L DL G KIRV   K G + L  GE  +L      G+ T  ++ ++YK  P+ V   D+
Sbjct: 67  LLGDLQGPKIRVSTFKEGKIILNEGEHFILDAELAKGEGTQESVGIDYKKLPQDVCNDDI 126

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG + L+V  V G  +   V+ GG L + KGIN     L  +A+T +D   I+ A 
Sbjct: 127 LLLDDGRVQLQVMRVEGNKIHTKVLVGGPLSNNKGINKKGGGLSADALTEKDKNDIRLAA 186

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAV---RNFDEILKASDG 244
           E  V+ + +SF  +  D +K    L +       +++K+ER + V    N D+I++ASD 
Sbjct: 187 EIQVEYLAVSFPRNGED-MKFARRLAQESGLYARMVAKVERAETVSCDENIDDIVRASDV 245

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           IM+ARGDLGVE+    L  +QK+LI +A    + VITATQM+ SM +  +PTRAEV DVA
Sbjct: 246 IMVARGDLGVEIGDPELIAVQKKLISRAKKLNRVVITATQMMESMISNPMPTRAEVMDVA 305

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMS-RLRELVEDGTRGT 363
           NA+LDGTDAVMLS ETA GK+P++ VK MA++    E+  ES   + R++ +       T
Sbjct: 306 NAVLDGTDAVMLSGETAAGKYPVETVKAMAEVCIGAEKMIESNEQNYRIKSVFR-----T 360

Query: 364 IKEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
            +EAIA S I A   L  +K ++T T +GRTA + SR      IF  S N+   N     
Sbjct: 361 EEEAIAMSTIYAANHLEGVKAMVTLTESGRTALMTSRLNSVFPIFAMSANQATLNRCALL 420

Query: 423 YGVYAFCLE----EGFDER-DIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
            GV  F  +     G +     +  +K   L+E  D+V++T+G  +     TN ++I  +
Sbjct: 421 RGVIPFYFDTKQASGLEAAIAALDALKERNLLEEGDLVIITQGDIMGVEGSTNCMRILPV 480


>pir||S64635 pyruvate kinase (EC 2.7.1.40), muscle splice form M1 - human
           Length = 531
           
 Score =  292 bits (739), Expect = 7e-78
 Identities = 177/473 (37%), Positives = 275/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V RLNFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPPPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      ELV  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELVRA 401

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            +  T + EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 402 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTAR 461

Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 462 QAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514


>gb|AAG21457.1|AC021894_17 (AC021894) Pyruvate Kinase copy 2 [Leishmania major]
           Length = 499
           
 Score =  292 bits (739), Expect = 7e-78
 Identities = 172/456 (37%), Positives = 259/456 (56%), Gaps = 17/456 (3%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
           T+IV TIGP+T S   +K LI++G+SV R+NFSHGS E H   I  VR  + +L   +AI
Sbjct: 22  TRIVCTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAI 81

Query: 71  LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDV 127
             D  G +IR G+  GG   ++RG    +TT     D+ T     ++Y++  ++V  G  
Sbjct: 82  ALDTKGPEIRTGQFVGGEAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGSY 141

Query: 128 IYLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
           IY+ DG ++L V+     Q ++  V +   +  R+G+N+P   + + AV+ +D   ++F 
Sbjct: 142 IYIDDGILILHVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFG 201

Query: 187 IEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIM 246
           +EQGVD I  SF+ S   V  V+  L      D+ +I KIE    V+N D I++ SDGIM
Sbjct: 202 VEQGVDMIFASFIRSAEQVGDVRKALGAK-GHDIMIICKIENHQGVQNIDSIIEESDGIM 260

Query: 247 IARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANA 306
           +ARGDLGVE+P E++ + QK LI K N  GKPVI ATQML SMT    PTRAEV+DVANA
Sbjct: 261 VARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANA 320

Query: 307 ILDGTDAVMLSEETAIGKFPIDAVKMMAKIA----KVTEEYRESFGMSRLRELVEDGTRG 362
           + +G D VMLS ETA GK+P + V+ MA+I         EY     + +L+ +       
Sbjct: 321 VFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVFFNSIKKLQPIPM----- 375

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
           + +EA+  S ++++     K ++  + TGR+ARL+++++P   I   +T  + C  L  +
Sbjct: 376 SAEEAVCSSAVNSVYETKAKVMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNIT 435

Query: 423 YGVYAFCLEE---GFDERDIIRLIKGLGLVESDDIV 455
            GV +   +    G DE    R+  G+G  +S   V
Sbjct: 436 QGVESVFFDAEKLGHDEGKEQRVAMGVGFAKSKGYV 471


>sp|P94939|KPYK_MYCIT PYRUVATE KINASE (PK) >gi|1750255|gb|AAB39214.1| (U65430) pyruvate
           kinase [Mycobacterium intracellulare]
           Length = 472
           
 Score =  291 bits (738), Expect = 9e-78
 Identities = 181/470 (38%), Positives = 262/470 (55%), Gaps = 12/470 (2%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           KIV T+GPAT+S  +I  L+E G+ V RLNFSHG + +H    E+VR  S    R V +L
Sbjct: 6   KIVCTLGPATNSDELILALVEAGMDVARLNFSHGDYADHKAAYERVRVASDATGRAVGVL 65

Query: 72  ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYLS 131
           ADL G KIR+G    G      GE V +T  D  G    +   YK      + GD + + 
Sbjct: 66  ADLQGPKIRLGRFATGPTYWADGETVRITVADCEGSHDRVSTTYKKLAEDAAVGDRVLVD 125

Query: 132 DGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGV 191
           DG + L V+ + G DV   VV GG + + KGI++P   +   A++ +D+E + FA++ GV
Sbjct: 126 DGKVCLVVDGIEGDDVICTVVEGGPVSNNKGISLPGMNVSAPALSEKDIEDLTFALDLGV 185

Query: 192 DAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGD 251
           D + LSFV S  DV  V   +++     V VI+K+E+P+AV N + I+ A D IM+ARGD
Sbjct: 186 DLVALSFVRSPADVELVHEVMDR-VGRRVPVIAKLEKPEAVDNLETIVLAFDAIMVARGD 244

Query: 252 LGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGT 311
           LGVE+P+E +P++QK  I+ A    KPVI ATQML SM     PTRAE +DVANA+LDG 
Sbjct: 245 LGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGA 304

Query: 312 DAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIARS 371
           DAVMLS ET++GK+P+ AV+ M++I    E+   S     L   V    RG I  A AR 
Sbjct: 305 DAVMLSGETSVGKYPMAAVRTMSRIICAVED--NSTAAPPLTH-VPRTKRGVISYA-ARD 360

Query: 372 IIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCL- 430
           I +    L+ K ++  T++G T + ++R      +  F+    V + L  ++G   F + 
Sbjct: 361 IGE---RLDAKALVAFTQSGDTVKRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVP 417

Query: 431 ---EEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
                G   R + + +  LG  +  D+V++  G P      TN I + +I
Sbjct: 418 MMTSTGGMIRQVDKSLLELGRYKRGDLVVIVAGAPPGTVGSTNLIHVHRI 467


>sp|P11979|KPY1_FELCA PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
           >gi|89089|pir||A25091 pyruvate kinase (EC 2.7.1.40),
           muscle splice form M1 [validated] - cat
           >gi|1311281|pdb|1PKM|  Pyruvate Kinase Mol_id: 1;
           Molecule: M1 Pyruvate Kinase; Chain: Null; Synonym: Pk;
           Ec: 2.7.1.40
           Length = 530
           
 Score =  291 bits (737), Expect = 1e-77
 Identities = 176/473 (37%), Positives = 274/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ TIGPA+ S  ++K++I++G++V RLNFSHG+ E HA+ I+ VR  ++        
Sbjct: 44  TGIICTIGPASRSVEILKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIR 103

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENVLWLDYKNI 163

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L V+E     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVEVGSKVYVDDGLISLLVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 223

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 282

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 342

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      ELV  
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELVRG 400

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            +  T + EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460

Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKHGDVVIVLTG 513


>sp|P34038|KPYK_LACDE PYRUVATE KINASE >gi|1154865|emb|CAA50527.1| (X71403) pyruvate
           kinase [Lactobacillus delbrueckii]
           Length = 589
           
 Score =  291 bits (736), Expect = 1e-77
 Identities = 172/472 (36%), Positives = 268/472 (56%), Gaps = 8/472 (1%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV+T+GPA+     I KL E G +V R NFSHG+ EEH   +  VR++ +K  + + 
Sbjct: 3   KTKIVSTLGPASDDIETITKLAEAGANVFRFNFSHGNHEEHLARMNMVREVEKKTGKLLG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKV-VLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
           I  D  G +IR  + +GG   +  G+++ V       G++  I V Y         G  +
Sbjct: 63  IALDTKGAEIRTTDQEGGKFTINTGDEIRVSMDATKAGNKDMIHVTYPGLFDDTHVGGTV 122

Query: 129 YLSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
            + DG + L ++    +  E V    + G + S+KG+N P   + +  +T +D + I+F 
Sbjct: 123 LIDDGAVGLTIKAKDEEKRELVCEAQNTGVIGSKKGVNAPGVEIRLPGITEKDTDDIRFG 182

Query: 187 IEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIM 246
           ++ G++ I  SFV    DVL +++  E+ +A  V +  KIE  + + N DEIL+ SDG+M
Sbjct: 183 LKHGINFIFASFVRKAQDVLDIRALCEEANASYVKIFPKIESQEGIDNIDEILQVSDGLM 242

Query: 247 IARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANA 306
           +ARGD+GVE+P   +P +QK LI+K N  GKPVITATQML SM     PTRAEVTDVANA
Sbjct: 243 VARGDMGVEIPFINVPFVQKTLIKKCNALGKPVITATQMLDSMQENPRPTRAEVTDVANA 302

Query: 307 ILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
           +LDGTDA MLS E+A G +P+ +V+ M  I   TE+  ++     L+   E+     + E
Sbjct: 303 VLDGTDATMLSGESANGLYPVQSVQAMHDIDVRTEKELDTRNTLALQRF-EEYKGSNVTE 361

Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
           AI  S++     L +K I+  T +G TAR+IS+++P   I   + +E++ ++L   +GV 
Sbjct: 362 AIGESVVRTAQELGVKTIIAATSSGYTARMISKYRPDATIVALTFDEKIQHSLGIVWGVE 421

Query: 427 AFCLEE--GFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
               ++    DE   +  R+ K  G V+  D+V++  G P  ++  TN +K+
Sbjct: 422 PVLAKKPSNTDEMFEEAARVAKEHGFVKDGDLVIIVAGVPFGQSGTTNLMKL 473


>gb|AAA92535.1| (U47654) pyruvate kinase PK-R isoenzyme [Homo sapiens]
           Length = 587
           
 Score =  290 bits (734), Expect = 3e-77
 Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  VR+  +        
Sbjct: 101 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 160

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VEL +G +V++T        G+  T+ V+Y + 
Sbjct: 161 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 220

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V  G  IY+ DG I L V+++  + +   V +GG L SRKG+N+P A + +  ++ +
Sbjct: 221 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 280

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E GVD +  SFV    DV  V++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 281 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 339

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 340 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 399

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM   IA+  E    +R+ F  + R   
Sbjct: 400 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 459

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T TGR+A+L+SR++P+  +   + + +
Sbjct: 460 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 514

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +    GV+     E
Sbjct: 515 AARQVHLCRGVFPLLYRE 532


>gb|AAA92536.1| (U47654) pyruvate kinase PK-L isoenzyme [Homo sapiens]
           Length = 566
           
 Score =  290 bits (734), Expect = 3e-77
 Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  VR+  +        
Sbjct: 80  TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 139

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VEL +G +V++T        G+  T+ V+Y + 
Sbjct: 140 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 199

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V  G  IY+ DG I L V+++  + +   V +GG L SRKG+N+P A + +  ++ +
Sbjct: 200 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 259

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E GVD +  SFV    DV  V++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 260 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 318

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 319 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 378

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM   IA+  E    +R+ F  + R   
Sbjct: 379 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 438

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T TGR+A+L+SR++P+  +   + + +
Sbjct: 439 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 493

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +    GV+     E
Sbjct: 494 AARQVHLCRGVFPLLYRE 511


>pir||A30150 pyruvate kinase (EC 2.7.1.40) isoform R (erythroid) - human
           >gi|3449054|dbj|BAA02515.1| (D13243) pyruvate kinase L
           [Homo sapiens]
           Length = 599
           
 Score =  290 bits (734), Expect = 3e-77
 Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  VR+  +        
Sbjct: 113 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 172

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VEL +G +V++T        G+  T+ V+Y + 
Sbjct: 173 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 232

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V  G  IY+ DG I L V+++  + +   V +GG L SRKG+N+P A + +  ++ +
Sbjct: 233 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 292

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E GVD +  SFV    DV  V++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 293 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 351

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 352 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 411

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM   IA+  E    +R+ F  + R   
Sbjct: 412 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 471

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T TGR+A+L+SR++P+  +   + + +
Sbjct: 472 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 526

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +    GV+     E
Sbjct: 527 AARQVHLCRGVFPLLYRE 544


>gi|10835121 pyruvate kinase, liver and RBC; Pyruvate kinase, liver and RBC type
           [Homo sapiens] >gi|8247933|sp|P30613|KPYR_HUMAN PYRUVATE
           KINASE, ISOZYMES R/L >gi|3327365|dbj|BAA31706.1|
           (AB015983) pyruvate kinase L [Homo sapiens]
           Length = 574
           
 Score =  290 bits (734), Expect = 3e-77
 Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  VR+  +        
Sbjct: 88  TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 147

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VEL +G +V++T        G+  T+ V+Y + 
Sbjct: 148 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 207

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V  G  IY+ DG I L V+++  + +   V +GG L SRKG+N+P A + +  ++ +
Sbjct: 208 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 267

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E GVD +  SFV    DV  V++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 268 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 326

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 386

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM   IA+  E    +R+ F  + R   
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 446

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T TGR+A+L+SR++P+  +   + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 501

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +    GV+     E
Sbjct: 502 AARQVHLCRGVFPLLYRE 519


>pir||KIHUPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice form R - human
           Length = 574
           
 Score =  290 bits (734), Expect = 3e-77
 Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  VR+  +        
Sbjct: 88  TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 147

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VEL +G +V++T        G+  T+ V+Y + 
Sbjct: 148 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 207

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V  G  IY+ DG I L V+++  + +   V +GG L SRKG+N+P A + +  ++ +
Sbjct: 208 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 267

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E GVD +  SFV    DV  V++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 268 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 326

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM   IA+  E    +R+ F  + R   
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 446

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T TGR+A+L+SR++P+  +   + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 501

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +    GV+     E
Sbjct: 502 AARQVHLCRGVFPLLYRE 519


>pir||KIHUPL pyruvate kinase (EC 2.7.1.40), hepatic splice form L - human
           Length = 543
           
 Score =  290 bits (734), Expect = 3e-77
 Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S   +K++I+ G+++ RLNFSHGS E HA+ I  VR+  +        
Sbjct: 57  TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 116

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VEL +G +V++T        G+  T+ V+Y + 
Sbjct: 117 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 176

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V  G  IY+ DG I L V+++  + +   V +GG L SRKG+N+P A + +  ++ +
Sbjct: 177 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 236

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E GVD +  SFV    DV  V++ L   +   + +ISKIE  + V+ FDEI
Sbjct: 237 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 295

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM   IA+  E    +R+ F  + R   
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 415

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T TGR+A+L+SR++P+  +   + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 470

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +    GV+     E
Sbjct: 471 AARQVHLCRGVFPLLYRE 488


>sp|P11980|KPY1_RAT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
           >gi|92715|pir||B26186 pyruvate kinase (EC 2.7.1.40)
           isozyme M1 - rat >gi|56929|emb|CAA33799.1| (X15800)
           pyruvate kinase [Rattus norvegicus]
           >gi|206204|gb|AAB93666.1| (M24359) M1 pyruvate kinase
           [Rattus norvegicus]
           Length = 531
           
 Score =  289 bits (733), Expect = 3e-77
 Identities = 179/473 (37%), Positives = 275/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S  M+K++I++G++V RLNFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V+E     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      EL   
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAVFHRLLFEELARA 401

Query: 359 GTRGTIK-EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            ++ T   EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 402 SSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTAR 461

Query: 418 NLMFSYGVY-AFCLEEGFD--ERDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++   C +   D    D+       + + K  G  +  D+V++  G
Sbjct: 462 QAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514


>sp|P11981|KPY2_RAT PYRUVATE KINASE, M2 ISOZYME >gi|92716|pir||A26186 pyruvate kinase
           (EC 2.7.1.40) isozyme M2 - rat >gi|206205|gb|AAB93667.1|
           (M24359) M2 pyruvate kinase [Rattus norvegicus]
           Length = 531
           
 Score =  289 bits (732), Expect = 4e-77
 Identities = 181/476 (38%), Positives = 278/476 (58%), Gaps = 32/476 (6%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S  M+K++I++G++V RLNFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V+E     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458

Query: 415 VCNNLMFSYGVY-AFCLEEGFD--ERDI-------IRLIKGLGLVESDDIVLMTEG 460
                    G++   C +   D    D+       + + K  G  +  D+V++  G
Sbjct: 459 TARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514


>gb|AAA41882.1| (M17091) R-pyruvate kinase [Rattus norvegicus]
           Length = 574
           
 Score =  289 bits (732), Expect = 4e-77
 Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I  +R+ ++        
Sbjct: 88  TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAEYIANIREATESFATSPLS 147

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VE+ +G +V++T        GD  T+ V+Y + 
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 207

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V+ G  IY+ DG I L V+++  + +   V  GG L SRKG+N+P   + +  ++ +
Sbjct: 208 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 267

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F ++  VD I  SFV    DVL V+  L   + +++ +ISKIE  + V+ FDEI
Sbjct: 268 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKRFDEI 326

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AV M   IA+  E    +R+ F  + R   
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 446

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T+TGR+A+L+S+++P+  +   + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 501

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +  S GV+     E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519


>gb|AAA41883.1| (M17091) L-pyruvate kinase [Rattus norvegicus]
           Length = 543
           
 Score =  289 bits (732), Expect = 4e-77
 Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I  +R+ ++        
Sbjct: 57  TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAEYIANIREATESFATSPLS 116

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VE+ +G +V++T        GD  T+ V+Y + 
Sbjct: 117 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 176

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V+ G  IY+ DG I L V+++  + +   V  GG L SRKG+N+P   + +  ++ +
Sbjct: 177 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 236

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F ++  VD I  SFV    DVL V+  L   + +++ +ISKIE  + V+ FDEI
Sbjct: 237 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKRFDEI 295

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AV M   IA+  E    +R+ F  + R   
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 415

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T+TGR+A+L+S+++P+  +   + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 470

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +  S GV+     E
Sbjct: 471 AARQVHLSRGVFPLLYRE 488


>gi|6981360 pyruvate kinase, liver and RBC [Rattus norvegicus]
           >gi|66856|pir||KIRTPL pyruvate kinase (EC 2.7.1.40),
           hepatic splice form L - rat >gi|57854|emb|CAA27158.1|
           (X03430) put. L-type pyruvate kinase (aa 1-543) [Rattus
           norvegicus] >gi|206202|gb|AAA41881.1| (M17685) L-type
           pyruvate kinase [Rattus norvegicus]
           >gi|297533|emb|CAA29169.1| (X05684) L-type pyruvate
           kinase [Rattus norvegicus]
           Length = 543
           
 Score =  289 bits (731), Expect = 6e-77
 Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I  +R+ ++        
Sbjct: 57  TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 116

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VE+ +G +V++T        GD  T+ V+Y + 
Sbjct: 117 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 176

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V+ G  IY+ DG I L V+++  + +   V  GG L SRKG+N+P   + +  ++ +
Sbjct: 177 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 236

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F ++  VD I  SFV    DVL V+  L   + +++ +ISKIE  + V+ FDEI
Sbjct: 237 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFDEI 295

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AV M   IA+  E    +R+ F  + R   
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 415

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T+TGR+A+L+S+++P+  +   + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 470

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +  S GV+     E
Sbjct: 471 AARQVHLSRGVFPLLYRE 488


>pir||A23612 pyruvate kinase (EC 2.7.1.40) L - rat >gi|206199|gb|AAA41880.1|
           (M11709) L-type pyruvate kinase [Rattus norvegicus]
           >gi|224883|prf||1203257A kinase L,pyruvate [Rattus
           norvegicus]
           Length = 543
           
 Score =  289 bits (731), Expect = 6e-77
 Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I  +R+ ++        
Sbjct: 57  TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 116

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VE+ +G +V++T        GD  T+ V+Y + 
Sbjct: 117 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 176

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V+ G  IY+ DG I L V+++  + +   V  GG L SRKG+N+P   + +  ++ +
Sbjct: 177 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 236

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F ++  VD I  SFV    DVL V+  L   + +++ +ISKIE  + V+ FDEI
Sbjct: 237 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFDEI 295

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AV M   IA+  E    +R+ F  + R   
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 415

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T+TGR+A+L+S+++P+  +   + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTGSAK 470

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +  S GV+     E
Sbjct: 471 AARQVHLSRGVFPLLYRE 488


>sp|P12928|KPYR_RAT PYRUVATE KINASE, ISOZYMES R/L (L-PK)
           Length = 574
           
 Score =  289 bits (731), Expect = 6e-77
 Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I  +R+ ++        
Sbjct: 88  TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 147

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VE+ +G +V++T        GD  T+ V+Y + 
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 207

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V+ G  IY+ DG I L V+++  + +   V  GG L SRKG+N+P   + +  ++ +
Sbjct: 208 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 267

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F ++  VD I  SFV    DVL V+  L   + +++ +ISKIE  + V+ FDEI
Sbjct: 268 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFDEI 326

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AV M   IA+  E    +R+ F  + R   
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 446

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T+TGR+A+L+S+++P+  +   + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 501

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +  S GV+     E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519


>sp|P70789|KPY3_AGRVI PYRUVATE KINASE (PK) >gi|984370|gb|AAB61625.1| (U32375) pyruvate
           kinase [Agrobacterium vitis]
           Length = 474
           
 Score =  288 bits (730), Expect = 8e-77
 Identities = 175/479 (36%), Positives = 269/479 (55%), Gaps = 22/479 (4%)

Query: 8   DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
           + + KIVAT+GPA+SS  +++ L   GV   RLNFSHGS ++HA     +R + ++L   
Sbjct: 6   NRRAKIVATVGPASSSPAILRSLFLAGVDTFRLNFSHGSRDDHAAAYRHIRALEKELGTS 65

Query: 68  VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET-----TIPVEYKDFPRLV 122
           + IL DL G KIR+G +  G ++L +  ++    R V G E       IP+ +++    V
Sbjct: 66  IGILQDLQGPKIRIGVLHEGRLQLTKDAEI----RFVCGTEPGRGLMDIPLPHREIFAAV 121

Query: 123 SKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI 182
             GD + + DG + +R   V  + ++A V+  G + +RKG+N+P   L +  +TP+D + 
Sbjct: 122 KPGDDLLIDDGRVRVRALGVSDEFIDAKVIVAGPISNRKGVNLPGTVLDISPLTPKDRKD 181

Query: 183 IKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
           ++F +E GVD I LSFV +  D+++ +S +    ++   +I+KIE+P A+   D+I+  S
Sbjct: 182 LEFGLELGVDWIALSFVQTARDMIEARSLV----SDRAGLIAKIEKPSALDEIDDIVALS 237

Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
           D IM+ARGDLGVE+P E +P  QKELIR      KPVI ATQML SM     PTRAE +D
Sbjct: 238 DAIMVARGDLGVEIPPEDVPGRQKELIRACRIAAKPVIVATQMLDSMVTSPTPTRAEASD 297

Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
           VA AI DG DAVMLS E+A G FP++ V++M++I + TE+++       + E  E     
Sbjct: 298 VAGAIYDGADAVMLSAESATGAFPVETVEIMSRIIEKTEKHK---FYRPILEATEPQIAH 354

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
           T   A+A +  D    L    I+  T +G TA  ISR +P   I   + +E+    L   
Sbjct: 355 TPPHAVATAAADVALALKAPVIVAFTVSGTTASRISRARPPLPILALTPSEQTARQLGLM 414

Query: 423 YGVYAFCLEEGFD--ERDIIRLIKG---LGLVESDDIVLMTEGKPIEKTMGTNSIKIFQ 476
           +GV +  L    D  E+ + R  +     GL E  D +++  G P      TN++++ Q
Sbjct: 415 WGVVSL-LSPTVDTYEQSVDRATQAAVQTGLAEKSDQIVVVTGFPFATAGSTNNLRVTQ 472


>pdb|1A49|A Chain A, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
           >gi|4929840|pdb|1A49|B Chain B, Bis Mg-Atp-K-Oxalate
           Complex Of Pyruvate Kinase >gi|4929841|pdb|1A49|C Chain
           C, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
           >gi|4929842|pdb|1A49|D Chain D, Bis Mg-Atp-K-Oxalate
           Complex Of Pyruvate Kinase >gi|4929843|pdb|1A49|E Chain
           E, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
           >gi|4929844|pdb|1A49|F Chain F, Bis Mg-Atp-K-Oxalate
           Complex Of Pyruvate Kinase >gi|4929845|pdb|1A49|G Chain
           G, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
           >gi|4929846|pdb|1A49|H Chain H, Bis Mg-Atp-K-Oxalate
           Complex Of Pyruvate Kinase >gi|4557921|pdb|1A5U|A Chain
           A, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
           >gi|4557922|pdb|1A5U|B Chain B, Pyruvate Kinase Complex
           With Bis Mg-Atp-Na-Oxalate >gi|4557923|pdb|1A5U|C Chain
           C, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
           >gi|4557924|pdb|1A5U|D Chain D, Pyruvate Kinase Complex
           With Bis Mg-Atp-Na-Oxalate >gi|4557925|pdb|1A5U|E Chain
           E, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
           >gi|4557926|pdb|1A5U|F Chain F, Pyruvate Kinase Complex
           With Bis Mg-Atp-Na-Oxalate >gi|4557927|pdb|1A5U|G Chain
           G, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
           >gi|4557928|pdb|1A5U|H Chain H, Pyruvate Kinase Complex
           With Bis Mg-Atp-Na-Oxalate >gi|3659945|pdb|1AQF|A Chain
           A, Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|3659946|pdb|1AQF|B Chain B,
           Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|3659947|pdb|1AQF|C Chain C,
           Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|3659948|pdb|1AQF|D Chain D,
           Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|3659950|pdb|1AQF|F Chain F,
           Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|3659951|pdb|1AQF|G Chain G,
           Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|3659952|pdb|1AQF|H Chain H,
           Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|3659949|pdb|1AQF|E Chain E,
           Pyruvate Kinase From Rabbit Muscle With Mg, K, And
           L-Phospholactate >gi|2231167|gb|AAB61963.1| (U09028)
           muscle pyruvate kinase [Oryctolagus cuniculus]
           Length = 530
           
 Score =  288 bits (730), Expect = 8e-77
 Identities = 174/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V R+NFSHG+ E HA+ I+ VR  ++       L
Sbjct: 44  TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      EL   
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 400

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            +  T + EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460

Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513


>sp|P11974|KPY1_RABIT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
           Length = 531
           
 Score =  288 bits (730), Expect = 8e-77
 Identities = 174/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V R+NFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      EL   
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 401

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            +  T + EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 402 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 461

Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 462 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514


>gb|AAC48536.1| (U44751) pyruvate kinase [Oryctolagus cuniculus]
           >gi|1589159|prf||2210328A pyruvate kinase [Oryctolagus
           cuniculus]
           Length = 530
           
 Score =  287 bits (728), Expect = 1e-76
 Identities = 174/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V R+NFSHG+ E HA+ I+ VR  ++       L
Sbjct: 44  TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      EL   
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARA 400

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            +  T + EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460

Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513


>sp|O06134|KPYK_MYCTU PYRUVATE KINASE (PK) >gi|7434446|pir||G70557 probable pykA protein
           - Mycobacterium tuberculosis (strain H37RV)
           >gi|2113901|emb|CAB08894.1| (Z95554) pykA [Mycobacterium
           tuberculosis]
           Length = 472
           
 Score =  287 bits (728), Expect = 1e-76
 Identities = 175/470 (37%), Positives = 259/470 (54%), Gaps = 12/470 (2%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           KIV T+GPAT   ++++ L+E G+ V R+NFSHG +++H    E+VR  S    R V +L
Sbjct: 6   KIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAVGVL 65

Query: 72  ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYLS 131
           ADL G KIR+G    G      GE V +T     G    +   YK   +    GD + + 
Sbjct: 66  ADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDRVSTTYKRLAQDAVAGDRVLVD 125

Query: 132 DGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGV 191
           DG + L V+ V G DV   VV GG +   KGI++P   +   A++ +D+E + FA+  GV
Sbjct: 126 DGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGV 185

Query: 192 DAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGD 251
           D + LSFV S  DV  V   +++     V VI+K+E+P+A+ N + I+ A D +M+ARGD
Sbjct: 186 DMVALSFVRSPADVELVHEVMDR-IGRRVPVIAKLEKPEAIDNLEAIVLAFDAVMVARGD 244

Query: 252 LGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGT 311
           LGVE+P+E +P++QK  I+ A    KPVI ATQML SM     PTRAE +DVANA+LDG 
Sbjct: 245 LGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGA 304

Query: 312 DAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIARS 371
           DA+MLS ET++GK+P+ AV+ M++I    EE   S     L  +     RG I  A AR 
Sbjct: 305 DALMLSGETSVGKYPLAAVRTMSRIICAVEE--NSTAAPPLTHIPRT-KRGVISYA-ARD 360

Query: 372 IIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLE 431
           I +    L+ K ++  T++G T R ++R      +  F+    V + L  ++G   F + 
Sbjct: 361 IGE---RLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVP 417

Query: 432 EGFDERDIIRLIK----GLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           +      +IR +      L   +  D+V++  G P      TN I + +I
Sbjct: 418 KMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRI 467


>sp|P14618|KPY1_HUMAN PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
           (CYTOSOLIC THYROID HORMONE-BINDING PROTEIN) (CTHBP)
           (THBP1) >gi|478822|pir||S30038 pyruvate kinase (EC
           2.7.1.40), muscle splice form M2 - human
           >gi|35505|emb|CAA39849.1| (X56494) pyruvate kinase [Homo
           sapiens]
           Length = 531
           
 Score =  287 bits (727), Expect = 2e-76
 Identities = 178/476 (37%), Positives = 277/476 (57%), Gaps = 32/476 (6%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V RLNFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPPPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458

Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                    G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 459 TARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514


>pir||B81239 pyruvate kinase II NMB0089 [imported] - Neisseria meningitidis
           (group B strain MD58) >gi|7225307|gb|AAF40552.1|
           (AE002368) pyruvate kinase II [Neisseria meningitidis
           MC58]
           Length = 490
           
 Score =  287 bits (726), Expect = 2e-76
 Identities = 178/479 (37%), Positives = 272/479 (56%), Gaps = 12/479 (2%)

Query: 9   HKTKIVATIGPATSSRNMIKKLIE-NGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
           H TKIVAT+GP +++  +++ +I   G++VVR NFSHG+ E H +    VR+ +++  + 
Sbjct: 13  HNTKIVATLGPGSNNVELLEDMIRVGGLNVVRFNFSHGTPEFHQENALIVREAAKRAGQE 72

Query: 68  VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGD 126
           +AI+ADL G KIRVG+I GG +EL +GE +VL    +  G    + ++Y+D P  V+ GD
Sbjct: 73  IAIIADLQGPKIRVGKIAGGGIELNKGETLVLDAALEGEGTREAVGLDYRDLPDDVAAGD 132

Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
           V++L DG + L VE V G  +   V +   L S KGIN     L   A+T +D   +K A
Sbjct: 133 VLWLDDGLLTLTVESVEGSRIITRVENSHVLKSNKGINKRGGGLSAGALTEKDFRDLKTA 192

Query: 187 IEQGVDAIGLSFVGSVYDV----LKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
           I  G D + +SFV S  D+     KV+  ++ + A    ++SKIER +A+ N DEI+ A 
Sbjct: 193 IAIGCDYLAISFVKSAEDLHIARAKVEEEMKGSTAVRPGLVSKIERVEAIENLDEIILAG 252

Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
           DGIM+ARGDL VE+    +P LQK +IR+A    +  ITATQM+ SM    VPTRAEV+D
Sbjct: 253 DGIMVARGDLAVEVGHAAVPALQKRMIRRARELRRFSITATQMMESMITNPVPTRAEVSD 312

Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
           VANA+LDGTDAVM S ETA+G +P + V  MA I    E+ ++S  ++ + E VE     
Sbjct: 313 VANAVLDGTDAVMCSAETAVGAYPFETVSQMAIICAAAEKEQDS--LNGVAEQVEYPEAV 370

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
           +   A+A   +     ++ K I+  T +G TA  ISR      IF  + +      +   
Sbjct: 371 STNLAVAGGAVSVARAVHAKAIVALTESGSTAFEISRHNITLPIFALTPSVSAQRRMAMY 430

Query: 423 YGVYAFCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
            GV    L    D    +  ++ +     ++ S D  ++T G  + ++  TN++++ ++
Sbjct: 431 RGVRPLILATSTDHDTALNEVETMLVEHNILHSGDQYIITSGSQMRESGSTNTLEVLRV 489


>pir||KIRTPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice form R - rat
           Length = 574
           
 Score =  287 bits (726), Expect = 2e-76
 Identities = 169/438 (38%), Positives = 261/438 (59%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I  +R+ ++        
Sbjct: 88  TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 147

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VE+ +G +V++T        GD  T+ V+Y + 
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 207

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            R+V+ G  IY+ DG I L V+++  + +   V  GG L SRKG+N+P   + +  ++ +
Sbjct: 208 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 267

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F ++  VD I  SFV    DVL V+  L   + +++ +ISKIE  + V+ F+EI
Sbjct: 268 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFNEI 326

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AV M   IA+  E    +R+ F  + R   
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 446

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T+TGR+A+L+S+++P+  +   + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 501

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +  S GV+     E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519


>sp|P00548|KPYK_CHICK PYRUVATE KINASE, MUSCLE ISOZYME >gi|66858|pir||KICHPM pyruvate
           kinase (EC 2.7.1.40), muscle - chicken
           >gi|212571|gb|AAA49020.1| (M18793) pyruvate kinase
           [Gallus gallus] >gi|212573|gb|AAA49021.1| (J00903)
           pyruvate kinase [Gallus gallus]
           Length = 530
           
 Score =  287 bits (726), Expect = 2e-76
 Identities = 176/473 (37%), Positives = 272/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ TIGPA+ S + +K++I++G++V RLNFSHG+ E H   I+ VR+ ++        
Sbjct: 44  TGIICTIGPASRSVDKLKEMIKSGMNVARLNFSHGTHEYHEGTIKNVREATESFASDPIT 103

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VAI  D  G +IR G IKG     VELK+G  + +T  +      DE  + V+YK+ 
Sbjct: 104 YRPVAIALDTKGPEIRTGLIKGSGTAEVELKKGAALKVTLDNAFMENCDENVLWVDYKNL 163

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            +++  G  IY+ DG I L V+E     V   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 IKVIDVGSKIYVDDGLISLLVKEKGKDFVMTEVENGGMLGSKKGVNLPGAAVDLPAVSEK 223

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV  V+  L +   + + +ISKIE  + VR FDEI
Sbjct: 224 DIQDLKFGVEQNVDMVFASFIRKAADVHAVRKVLGEK-GKHIKIISKIENHEGVRRFDEI 282

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           ++ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKP+I ATQML SM  +  PTRA
Sbjct: 283 MEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPIICATQMLESMIKKPRPTRA 342

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F   +  E++  
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAE--AAMFHRQQFEEILRH 400

Query: 359 GT-RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
                   +A+A   ++A        ++  T +GR+A L+SR++P+  I   + N++   
Sbjct: 401 SVHHREPADAMAAGAVEASFKCLAAALIVMTESGRSAHLVSRYRPRAPIIAVTRNDQTAR 460

Query: 418 NLMFSYGVY-AFCLEEGFD--ERDI-------IRLIKGLGLVESDDIVLMTEG 460
                 GV+   C +   D    D+       + + K  G  ++ D+V++  G
Sbjct: 461 QAHLYRGVFPVLCKQPAHDAWAEDVDLRVNLGMNVGKARGFFKTGDLVIVLTG 513


>gi|4505839 pyruvate kinase, muscle; Pyruvate kinase-3; Thyroid hormone-binding
           protein, cytosolic (p58) [Homo sapiens]
           >gi|125604|sp|P14786|KPY2_HUMAN PYRUVATE KINASE, M2
           ISOZYME >gi|88544|pir||JT0486 pyruvate kinase (EC
           2.7.1.40) M2 - human >gi|189998|gb|AAA36449.1| (M23725)
           M2-type pyruvate kinase [Homo sapiens]
           Length = 531
           
 Score =  287 bits (726), Expect = 2e-76
 Identities = 178/476 (37%), Positives = 277/476 (57%), Gaps = 32/476 (6%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V RLNFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458

Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                    G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 459 TARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514


>pdb|1PKN|   Pyruvate Kinase (E.C.2.7.1.40) Complexed With Manganese,
           Potassium, And Pyruvate
           Length = 530
           
 Score =  287 bits (726), Expect = 2e-76
 Identities = 172/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V R+NFSHG+ E HA+ I+ VR  ++       L
Sbjct: 44  TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDV---VGDETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMAACDENILWLDYKNI 163

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVEVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +++ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 224 DIQDLKFGVDEDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      EL   
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 400

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            +  T + EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460

Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKAAGFFKKGDVVIVLTG 513


>gi|8567390 pyruvate kinase liver and red blood cell [Mus musculus]
           >gi|1730067|sp|P53657|KPYR_MOUSE PYRUVATE KINASE,
           ISOZYMES R/L (L-PK) >gi|1174313|gb|AAB35435.1| (S79731)
           pyruvate kinase, PK [mice, CBA, Peptide, 574 aa] [Mus
           sp.] >gi|2653561|dbj|BAA23642.1| (D63764) pyruvate
           kinase [Mus musculus]
           Length = 574
           
 Score =  287 bits (726), Expect = 2e-76
 Identities = 171/438 (39%), Positives = 260/438 (59%), Gaps = 22/438 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
           T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I  +R+ ++        
Sbjct: 88  TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLS 147

Query: 66  -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
            R VAI  D  G +IR G ++GG    VE+ +G +V++T        GD  T+ V+Y + 
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNI 207

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V+ G  IY+ DG I L V ++  + +   V  GG L +RKG+N+P A + +  ++ +
Sbjct: 208 TQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQ 267

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D+  ++F +E  VD I  SFV    DV+ V+  L   +   + +ISKIE  + V+ FDEI
Sbjct: 268 DLLDLRFGVEHYVDIIFASFVRKASDVVAVRDALGP-EGRGIKIISKIENHEGVKKFDEI 326

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ SDGIM+ARGDLG+E+P E++ + QK +I + N  GKPV+ ATQML SM  +  PTRA
Sbjct: 327 LEVSDGIMMARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G FP++AVKM   IA+  E    +R+ F  + R   
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 446

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           L  D T     E  A   ++A        I+  T+TGR+A+L+SR++P+  +   + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQ 501

Query: 415 VCNNLMFSYGVYAFCLEE 432
               +  S GV+     E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519


>pdb|1PKL|G Chain G, The Structure Of Leishmania Pyruvate Kinase
           >gi|3660264|pdb|1PKL|D Chain D, The Structure Of
           Leishmania Pyruvate Kinase >gi|3660265|pdb|1PKL|E Chain
           E, The Structure Of Leishmania Pyruvate Kinase
           >gi|3660263|pdb|1PKL|C Chain C, The Structure Of
           Leishmania Pyruvate Kinase >gi|3660267|pdb|1PKL|H Chain
           H, The Structure Of Leishmania Pyruvate Kinase
           >gi|3660261|pdb|1PKL|A Chain A, The Structure Of
           Leishmania Pyruvate Kinase >gi|3660266|pdb|1PKL|F Chain
           F, The Structure Of Leishmania Pyruvate Kinase
           >gi|3660262|pdb|1PKL|B Chain B, The Structure Of
           Leishmania Pyruvate Kinase
           Length = 499
           
 Score =  287 bits (726), Expect = 2e-76
 Identities = 170/455 (37%), Positives = 258/455 (56%), Gaps = 17/455 (3%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           +I+ TIGP+T S   +K LI++G+SV R+NFSHGS E H   I  VR  + +L   +AI 
Sbjct: 23  RIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIA 82

Query: 72  ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDVI 128
            D  G +IR G+  GG   ++RG    +TT     D+ T     ++Y++  ++V  G+ I
Sbjct: 83  LDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYI 142

Query: 129 YLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           Y+ DG ++L+V+     Q +E  V +   +  R+G+N+P   + + AV+ +D   ++F +
Sbjct: 143 YIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGV 202

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD I  SF+ S   V  V+  L      D+ +I KIE    V+N D I++ SDGIM+
Sbjct: 203 EQGVDMIFASFIRSAEQVGDVRKALGPK-GRDIMIICKIENHQGVQNIDSIIEESDGIMV 261

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E++ + QK LI K N  GKPVI ATQML SMT    PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAV 321

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIA----KVTEEYRESFGMSRLRELVEDGTRGT 363
            +G D VMLS ETA GK+P + V+ MA+I         EY     + +L+ +       +
Sbjct: 322 FNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPM-----S 376

Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
             EA+  S ++++     K ++  + TGR+ARL+++++P   I   +T  + C  L  + 
Sbjct: 377 ADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 436

Query: 424 GVYAFCLEE---GFDERDIIRLIKGLGLVESDDIV 455
           GV +   +    G DE    R+  G+   +S   V
Sbjct: 437 GVESVFFDADKLGHDEGKEHRVAAGVEFAKSKGYV 471


>gi|6755074 pyruvate kinase 3 [Mus musculus] >gi|1405933|emb|CAA65761.1|
           (X97047) M2-type pyruvate kinase [Mus musculus]
           Length = 531
           
 Score =  286 bits (725), Expect = 3e-76
 Identities = 171/432 (39%), Positives = 262/432 (60%), Gaps = 22/432 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S  M+K++I++G++V RLNFSHG+ E HA+ I+ VR+ ++       L
Sbjct: 45  TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V+E     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI +TQML  M  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICSTQMLEIMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458

Query: 415 VCNNLMFSYGVY 426
                    G++
Sbjct: 459 TARQAHLYRGIF 470


>sp|P52480|KPY2_MOUSE PYRUVATE KINASE, M2 ISOZYME
           Length = 531
           
 Score =  286 bits (725), Expect = 3e-76
 Identities = 171/432 (39%), Positives = 262/432 (60%), Gaps = 22/432 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S  M+K++I++G++V RLNFSHG+ E HA+ I+ VR+ ++       L
Sbjct: 45  TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V+E     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI +TQML  M  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICSTQMLEIMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458

Query: 415 VCNNLMFSYGVY 426
                    G++
Sbjct: 459 TARQAHLYRGIF 470


>pir||A54113 pyruvate kinase (EC 2.7.1.40) - rabbit
           Length = 530
           
 Score =  286 bits (724), Expect = 4e-76
 Identities = 172/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V R+NFSHG+ E HA+ I+ VR  ++       L
Sbjct: 44  TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +++ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 224 DIQDLKFGVDEDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E     F      EL   
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 400

Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
            +  T + EA+A   ++A        ++  T +GR+A  ++R++P+  I   + N +   
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460

Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                 G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513


>pir||A33983 pyruvate kinase (EC 2.7.1.40) isozyme M2 - human
           >gi|338827|gb|AAA36672.1| (M26252) cytosolic thyroid
           hormone-binding protein (EC 2.7.1.40) [Homo sapiens]
           Length = 531
           
 Score =  286 bits (723), Expect = 5e-76
 Identities = 177/476 (37%), Positives = 277/476 (58%), Gaps = 32/476 (6%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V RLNFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPYL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     +ELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAELELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458

Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                    G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 459 TARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514


>pir||S55921 pyruvate kinase (EC 2.7.1.40) isozyme M2 - mouse
           >gi|551295|dbj|BAA07457.1| (D38379) pyruvate kinase M
           [Mus musculus] >gi|1098063|prf||2115223A pyruvate kinase
           M2 [Mus musculus]
           Length = 531
           
 Score =  286 bits (723), Expect = 5e-76
 Identities = 171/432 (39%), Positives = 261/432 (59%), Gaps = 22/432 (5%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S  M+K++I++G++V RLNFSHG+ E HA+ I+ VR+ ++       L
Sbjct: 45  TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILRLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  IY+ DG I L+V+E     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG E+P E++ + QK +I + N  GKPVI +TQML  M  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGTEIPAEKVFLSQKMMIGRCNRAGKPVICSTQMLEIMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458

Query: 415 VCNNLMFSYGVY 426
                    G++
Sbjct: 459 TARQAHLYRGIF 470


>pir||G82011 pyruvate kinase (EC 2.7.1.40) NMA0177 [imported] - Neisseria
           meningitidis (group A strain Z2491)
           >gi|7378949|emb|CAB83492.1| (AL162752) pyruvate kinase
           [Neisseria meningitidis Z2491]
           Length = 490
           
 Score =  285 bits (722), Expect = 7e-76
 Identities = 177/479 (36%), Positives = 271/479 (55%), Gaps = 12/479 (2%)

Query: 9   HKTKIVATIGPATSSRNMIKKLIE-NGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
           H TKIVAT+GP +++  +++ +I   G++VVR NFSHG+ E H +    VR+ +++  + 
Sbjct: 13  HNTKIVATLGPGSNNVELLEDMIRVGGLNVVRFNFSHGTPEFHQENARIVREAAKRTGQE 72

Query: 68  VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGD 126
           +AI+ADL G KIRVG+I GG +EL +GE + L    +  G    + ++Y+D P  V+ GD
Sbjct: 73  IAIIADLQGPKIRVGKIAGGGIELNKGETLGLDAALEGEGTREAVGLDYRDLPDDVAAGD 132

Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
           V++L DG + L VE V G  +   V +   L S KGIN     L   A+T +D   +K A
Sbjct: 133 VLWLDDGLLTLTVESVEGSRIITRVENSHVLKSNKGINKRGGGLSAGALTEKDFRDLKTA 192

Query: 187 IEQGVDAIGLSFVGSVYDV----LKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
           I  G D + +SFV S  D+     KV+  ++ + A    ++SKIER +A+ N DEI+ A 
Sbjct: 193 IAIGCDYLAISFVKSAEDLHIARAKVEEEMKGSTAVRPGLVSKIERVEAIENLDEIILAG 252

Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
           DGIM+ARGDL VE+    +P LQK +IR+A    +  ITATQM+ SM    VPTRAEV+D
Sbjct: 253 DGIMVARGDLAVEVGHAAVPALQKRMIRRARELRRFSITATQMMESMITNPVPTRAEVSD 312

Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
           VANA+LDGTDAVM S ETA+G +P + V  MA I    E+ ++S  ++ + E VE     
Sbjct: 313 VANAVLDGTDAVMCSAETAVGAYPFETVSQMAIICAAAEKEQDS--LNGVAEQVEYPEAV 370

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
           +   A+A   +     ++ K I+  T +G TA  ISR      IF  + +      +   
Sbjct: 371 STNLAVAGGAVSVARAVHAKAIVALTESGSTAFEISRHNITLPIFALTPSVSAQRRMAMY 430

Query: 423 YGVYAFCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
            GV    L    D    +  ++ +     ++ S D  ++T G  + ++  TN++++ ++
Sbjct: 431 RGVRPLILATSTDHDTALNEVETMLVEHNILHSGDQYIITSGSQMRESGSTNTLEVLRV 489


>sp|P30614|KPYK_YARLI PYRUVATE KINASE >gi|424047|gb|AAA18520.1| (M86863) pyruvate kinase
           [Yarrowia lipolytica]
           Length = 542
           
 Score =  284 bits (720), Expect = 1e-75
 Identities = 179/473 (37%), Positives = 267/473 (55%), Gaps = 27/473 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
           K+ I+ TIGP T+S  MI KL + G+++VR+NFSHGS+E H  VIE  R+  Q+   R +
Sbjct: 31  KSSIIGTIGPNTNSAEMISKLRQAGLNIVRMNFSHGSYEYHQSVIENARESEQRFRGRPL 90

Query: 69  AILADLPGLKIRVGEIKGGYV-ELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSK--- 124
           AI  D  G +IR G  K     ++K G  ++ +T     D+    + Y D+  +V +   
Sbjct: 91  AIALDTKGPEIRTGVTKDDKDWDVKAGHVMLFSTNPKYKDQCDDKIMYIDYTNIVKQIDI 150

Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           G +I++ DG +  +V E++ G+ ++   ++ GK+ SRKG+N+P   + + A++ +D   +
Sbjct: 151 GKIIFVDDGVLSFKVLEKIDGETLKVETLNNGKISSRKGVNLPGTDVDLPALSEKDKADL 210

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           KF +E GVD I  SFV +  DV  ++  L +   + + VISKIE    V NFDEILK +D
Sbjct: 211 KFGVEHGVDMIFASFVRTANDVQAIRDVLGEK-GKGIQVISKIENQQGVNNFDEILKETD 269

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P  ++ I QK+LI K N  GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 270 GVMVARGDLGIEIPAPQVFIAQKQLIAKCNLAGKPVICATQMLDSMTYNPRPTRAEVSDV 329

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGT 360
            NA+LDG D VMLS ETA G +PI++VKMM +   V E+   Y   F  + +R L    T
Sbjct: 330 GNAVLDGADCVMLSGETAKGTYPIESVKMMHETCLVAEKAIAYAPLF--NEMRTLTVRPT 387

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
                E IA S + A      + I+  + +G +ARL S+++P   I   + N +      
Sbjct: 388 ETV--ETIAISAVSASFEQQARAIIVLSTSGTSARLCSKYRPNCPILMVTRNAQAARFSH 445

Query: 421 FSYGVYAFCLEEGFD------ERDIIRLIK-------GLGLVESDDIVLMTEG 460
              GVY F   +         + D+   +K        LG++   D+V+  +G
Sbjct: 446 LYRGVYPFIYHKARASNPAEWQHDVEERLKWGMDEAVALGILNKGDVVVAIQG 498


>gb|AAB86587.1| (AF032389) pyruvate kinase; ATP:pyruvate 2-o-phosphotransferase
           [Oryctolagus cuniculus]
           Length = 530
           
 Score =  284 bits (720), Expect = 1e-75
 Identities = 176/476 (36%), Positives = 277/476 (57%), Gaps = 32/476 (6%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V R+NFSHG+ E HA+ I+ VR  ++       L
Sbjct: 44  TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 402

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 403 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNHQ 457

Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                    G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 458 TARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513


>sp|O18919|KPY2_RABIT PYRUVATE KINASE, M2 ISOZYME
           Length = 531
           
 Score =  284 bits (720), Expect = 1e-75
 Identities = 176/476 (36%), Positives = 277/476 (57%), Gaps = 32/476 (6%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
           T I+ TIGPA+ S   +K++I++G++V R+NFSHG+ E HA+ I+ VR  ++       L
Sbjct: 45  TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 104

Query: 65  DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
            R VA+  D  G +IR G IKG     VELK+G  + +T  +      DE  + ++YK+ 
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
            ++V  G  +Y+ DG I L+V++     +   V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 224

Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
           D++ +KF +EQ VD +  SF+    DV +V+  L +   +++ +ISKIE  + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 283

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           L+ASDGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 343

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
           E +DVANA+LDG D +MLS ETA G +P++AV+M   IA+  E    + + F  + RL  
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
           +  D T     EA A   ++A        I+  T++GR+A  ++R++P+  I   + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNHQ 458

Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
                    G++    ++   E    D+       + + K  G  +  D+V++  G
Sbjct: 459 TARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514


>sp|Q27686|KPYK_LEIME PYRUVATE KINASE (PK) >gi|577072|emb|CAA52898.1| (X74944) pyruvate
           kinase [Leishmania mexicana]
           Length = 499
           
 Score =  283 bits (717), Expect = 3e-75
 Identities = 169/455 (37%), Positives = 256/455 (56%), Gaps = 17/455 (3%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           +I+ TIGP+T S   +K LI++G+SV R+NFSHGS E H   I  VR  + +L   +AI 
Sbjct: 23  RIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIA 82

Query: 72  ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDVI 128
            D  G +IR G+  GG   ++RG    +TT     D+ T     ++Y++  ++V  G+ I
Sbjct: 83  LDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYI 142

Query: 129 YLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           Y+ DG ++L+V+     Q +E  V +   +  R+G+N+P   + + AV+ +D   ++F +
Sbjct: 143 YIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGV 202

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD I  SF+ S   V  V+  L      D+ +I KIE    V+N D I++ SDGIM+
Sbjct: 203 EQGVDMIFASFIRSAEQVGDVRKALGPK-GRDIMIICKIENHQGVQNIDSIIEESDGIMV 261

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E++ + QK LI K N  GKPVI ATQML SMT    PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAV 321

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIA----KVTEEYRESFGMSRLRELVEDGTRGT 363
            +G D VMLS ETA GK+P + V+ MA+I         EY     + +L+ +       +
Sbjct: 322 FNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPM-----S 376

Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
             EA+  S ++++     K ++  + TG  ARL+++++P   I   +T  + C  L  + 
Sbjct: 377 ADEAVCGSAVNSVSETKAKAMVVLSNTGAGARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 436

Query: 424 GVYAFCLEE---GFDERDIIRLIKGLGLVESDDIV 455
           GV +   +    G DE    R+  G+   +S   V
Sbjct: 437 GVESVFFDADKLGHDEGKEHRVAAGVEFAKSKGYV 471


>sp|Q40546|KPYG_TOBAC PYRUVATE KINASE ISOZYME G, CHLOROPLAST PRECURSOR
           >gi|629696|pir||S44287 pyruvate kinase, plastid - common
           tobacco >gi|482938|emb|CAA82223.1| (Z28374) Pyruvate
           kinase; plastid isozyme [Nicotiana tabacum]
           Length = 562
           
 Score =  282 bits (714), Expect = 6e-75
 Identities = 173/475 (36%), Positives = 267/475 (55%), Gaps = 13/475 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
           KTKIV TIGP+TSSR MI KL E G++V RLN SHG    H + I+ V++ + +  D+ +
Sbjct: 92  KTKIVCTIGPSTSSREMIWKLAEAGMNVARLNMSHGDHASHQRTIDLVKEYNAQFEDKVI 151

Query: 69  AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
           AI+ D  G ++  G++    + LK G++   + +  V  E T+ V Y DF   V  GD++
Sbjct: 152 AIMLDTKGPEVISGDVPKPIL-LKEGQEFNFSIKRGVSTEDTVSVNYDDFINDVEAGDIL 210

Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
            +  G + L V+      V+  V+ GG+L SR+ +N+      + ++T +D + IKF + 
Sbjct: 211 LVDGGMMSLAVKSKTSDIVKCEVIDGGELKSRRHLNVRGKSATLPSITEKDWDDIKFGVN 270

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
             VD   +SFV     V ++K +L+  +A D+ VI KIE  D++ N   I+ ASDG M+A
Sbjct: 271 NQVDFYAVSFVKDAKVVHELKDYLKSCNA-DIHVIVKIESADSIPNLHSIISASDGAMVA 329

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLG E+PIE +P+LQ+++IR+  +  KPVI AT ML SM     PTRAEV+D++ A+ 
Sbjct: 330 RGDLGAELPIEEVPLLQEDIIRRCQSMQKPVIVATNMLESMIDHPTPTRAEVSDISIAVR 389

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           +G DAVMLS ETA GK+P+ AVK+M  +A  TE   +    S  +        G +    
Sbjct: 390 EGADAVMLSGETAHGKYPLKAVKVMHIVALRTESSLQKSTSSPSQSAAYKSHMGEMFAFH 449

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
           + S+ + L T     I+  TRTG  A ++S  +P   +F F+ NERV   L   +GV   
Sbjct: 450 SSSMANTLST----PIIVFTRTGSMAIILSHNRPSSTVFAFTNNERVKQRLALYHGVVPI 505

Query: 429 CLEEGFDERD----IIRLIKGLGLVESDDIVLMTE--GKPIEKTMGTNSIKIFQI 477
            +E   D  +     I+L+    LV+    V + +   +PI +   T+ I++ ++
Sbjct: 506 YMEFSSDAEETFSRAIKLLLSKSLVKDGQYVTLVQSGAQPIWRRHSTHHIQVRKV 560


>pir||E82757 pyruvate kinase type II XF0824 [imported] - Xylella fastidiosa
           (strain 9a5c) >gi|9105726|gb|AAF83634.1|AE003922_4
           (AE003922) pyruvate kinase type II [Xylella fastidiosa]
           Length = 501
           
 Score =  282 bits (714), Expect = 6e-75
 Identities = 177/478 (37%), Positives = 271/478 (56%), Gaps = 18/478 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +T+I+AT+GPAT    ++  L + GV+VVRLNFSHG   + A+   +VR  +  +   + 
Sbjct: 20  RTRILATLGPATDPPGVLDALFKAGVNVVRLNFSHGDASDQARRAAEVRAAAAHVGVEIG 79

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEK--VVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
           ILADLPG KIR+G    G V L    +  ++  +   +GD T + V Y   P+ V+ GDV
Sbjct: 80  ILADLPGPKIRIGRFTEGKVRLVADARFDLLADSNAPLGDATQVGVSYLGLPQDVAAGDV 139

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG + L+V +V+G  +   V++ G L  RKG+N     L + A+T RD E+I    
Sbjct: 140 LLLDDGLMQLQVVQVQGARIVTTVLNDGVLSDRKGLNKQGGGLSLGALTDRDRELIGIVS 199

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
             GVD I +SF     ++ + +    +    D  ++SKIER +A+ N  EI+ ASD +M+
Sbjct: 200 RMGVDFIAVSFCRHAEEMHEARRIARECGC-DAALVSKIERAEAIVNLAEIVAASDVVMV 258

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+   +LP LQK++I++A  + K VITATQML SM    +PTRAEV DVANA+
Sbjct: 259 ARGDLGVEIGDAQLPGLQKKIIKEALLQNKVVITATQMLQSMVESPMPTRAEVLDVANAV 318

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTRGTI 364
           +DGTDAVMLS ETA G +P+ AV+ MA+I    E   E+   + M++      D      
Sbjct: 319 IDGTDAVMLSAETATGDYPVKAVEAMARICLGAEHQFEFDTDYEMAQRNLQRAD------ 372

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
             AIA + +     + +  ++  T +G T R +SRF+    I+ F+ +E V   ++   G
Sbjct: 373 -HAIAMATMFLSEHICLGGVVALTESGTTPRFLSRFRSHVPIYAFTRHEDVRRRMVLMRG 431

Query: 425 VYAFCLE-EGFDERD----IIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           V+    +  G   R+     IRL+   G +   D V+ T G+ +E    TN++++ ++
Sbjct: 432 VFPMRFDSRGLTPREAARATIRLLVECGCMSPGDRVVFTSGEHMETLGATNTLRLLEV 489


>dbj|BAB12236.1| (AB032276) pyruvate kinase [Aspergillus oryzae]
           Length = 526
           
 Score =  282 bits (713), Expect = 7e-75
 Identities = 172/472 (36%), Positives = 269/472 (56%), Gaps = 24/472 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQ-KLDRRV 68
           +T I+ TIGP T+S   I  L  +G++VVR+NFSHGS+E H  VI+  R+ ++ +  R +
Sbjct: 34  RTSIIGTIGPKTNSVEKINALRRSGLNVVRMNFSHGSYEYHQSVIDNAREAARVQTGRPL 93

Query: 69  AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDV---VGDETTIPVEYKDFPRLVSK 124
           AI  D  G +IR G       + +K G ++ +TT +      D+  + ++YK+   +++ 
Sbjct: 94  AIALDTKGPEIRTGNTTDDKDIPIKEGHELNITTDEKYANASDDQNMYLDYKNITNVIAP 153

Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           G +IY+ DG +  +V E V  + +    ++ G + SRKG+N+P   + + A++ +D+  +
Sbjct: 154 GKLIYVDDGILSFQVLEVVDDKTLRVKCLNNGNISSRKGVNLPGTDVDLPALSEKDISDL 213

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           KF ++ GVD I  SF+    D+  ++  L + + +++ +I+KIE    V NFDEIL+ +D
Sbjct: 214 KFGVKNGVDMIFASFIRRGSDIRHIRDVLGE-EGKEIQIIAKIENQQGVNNFDEILEETD 272

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P  ++ I QK +I K N +GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
           ANA+LDG D VMLS ETA G +P +AVKMM++   + E     F +   LR L    T  
Sbjct: 333 ANAVLDGADCVMLSGETAKGSYPCEAVKMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
              E+IA + + A   LN   I+  T +G TARL+S+++P   I   + N R        
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGNTARLLSKYRPVCPILMVTRNPRASRYSHLY 450

Query: 423 YGVYAFCLEEG-------FDERDIIRLIK-------GLGLVESDDIVLMTEG 460
            GV+ F   E          + D+ R +K        LG++   D ++  +G
Sbjct: 451 RGVWPFLFPENKPDFNVKIWQEDVDRRLKWAISHGIKLGIINKGDNIVCVQG 502


>sp|O51323|KPYK_BORBU PYRUVATE KINASE (PK) >gi|7434449|pir||C70143 pyruvate kinase (pyk)
           homolog - Lyme disease spirochete
           >gi|2688255|gb|AAC66733.1| (AE001141) pyruvate kinase
           (pyk) [Borrelia burgdorferi]
           Length = 477
           
 Score =  279 bits (707), Expect = 4e-74
 Identities = 178/473 (37%), Positives = 271/473 (56%), Gaps = 22/473 (4%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
           TKIVATI         IK L + GV+V+RLN +H S E+  KVI+ VR IS K    +A+
Sbjct: 6   TKIVATISDLRCEPEHIKDLHDAGVNVIRLNTAHQSHEDTIKVIDNVRKISNK----IAL 61

Query: 71  LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYL 130
           + D  G ++R   I+   + +K G+KV+++T  +  +       Y  F + V +G  + +
Sbjct: 62  MIDTKGPEVRTANIENPII-VKTGDKVIISTSPI-NEPNNFQTNYDGFVKEVPQGSKVLI 119

Query: 131 SDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQG 190
            DG + + V       +   + + G++ ++K IN P   L +++VT +D   I+ A +  
Sbjct: 120 DDGELEMTVVAKLPDRLICEIKNDGQIKNKKSINTPGISLKLQSVTEKDKGFIELAAKYN 179

Query: 191 VDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARG 250
           VD I  SFV    DV  V+  L  +   DV +ISKIE  + + N +EI KAS GIM+ARG
Sbjct: 180 VDFIAHSFVRHSKDVQDVQEILTASGNPDVKIISKIENQEGIDNIEEIAKASYGIMVARG 239

Query: 251 DLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDG 310
           D+GVE+P E +PI Q ++ +     G PVITATQML +M     PTRAEV+D+ANAIL+G
Sbjct: 240 DMGVEIPAEDVPIAQLKITQTCIKYGIPVITATQMLHTMIENPRPTRAEVSDIANAILNG 299

Query: 311 TDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLR-ELVEDGTRGTIKEAIA 369
           TDA+MLS ETA GK+PI+AVKMM  IAK  E++R+   M+  + EL  D  +   +  I 
Sbjct: 300 TDAIMLSGETAYGKYPIEAVKMMTSIAKKVEKHRK---MTLYKDELFYD--KSITRNYII 354

Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
           +  IDA   ++IK I+  +  G+TAR+++ ++    +F  + +ER+   L  SYGVY+  
Sbjct: 355 KCAIDATKLMDIKAIIVDSLKGKTARIMATYRASVPLFITTNSERLARELALSYGVYSNL 414

Query: 430 LEEGFDER-----DIIRLIKGLGLVESDDIVLMTEGKP---IEKTMGTNSIKI 474
           ++  F          ++++K  G+V   D V++  G P   IEK  GT  ++I
Sbjct: 415 VDNNFKRTTEFVVTSLKMLKEQGVVNDKDTVIIISGNPNRNIEK--GTEFMEI 465


>sp|Q57572|KPYK_METJA PYRUVATE KINASE (PK) >gi|2129228|pir||D64313 pyruvate kinase (EC
           2.7.1.40) - Methanococcus jannaschii
           >gi|1590885|gb|AAB98090.1| (U67468) pyruvate kinase
           [Methanococcus jannaschii]
           Length = 447
           
 Score =  279 bits (705), Expect = 6e-74
 Identities = 189/471 (40%), Positives = 271/471 (57%), Gaps = 33/471 (7%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKI+ T+GP  S  N + K I N +  VR N SH + +      EK  +I +K    +A
Sbjct: 7   KTKILVTLGP--SLENKLDKAI-NLIDGVRFNMSHATTD----YCEKFLNILEK--NNIA 57

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
            + DL G+KIR+ E+K     LK GEKVV      +G++  +          + +G  I 
Sbjct: 58  KVMDLKGIKIRIKEVKLKNKILKMGEKVV------IGEDIKLNYNIDT----IEEGHFIL 107

Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
           ++DG I LRV E +   + AVV  GG++    G+N+P   + +  +   D++ IKFA+E+
Sbjct: 108 INDGKIKLRVVE-KTDKIIAVVEVGGEIKEGMGVNLPDTRIELPIIDETDLKNIKFAVEK 166

Query: 190 GVDAIGLSFVGSVYDVLKVKSFLE--KNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
             + I LSFV +  DV ++K  +   K D E   VISKIE  + ++N  EI + SDG+M+
Sbjct: 167 DFEYIALSFVRNKEDVKELKDIISEYKGDCE---VISKIETKEGLKNIKEIARESDGVMV 223

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+PIE +PI QK ++R AN  G   ITATQ+L SM     PTRAEVTD+ANAI
Sbjct: 224 ARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAI 283

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
            DGTD +MLS ET IGK+PI+A+K++ K+AKV +E+ E FG  R+   VE     +I E 
Sbjct: 284 YDGTDCLMLSNETTIGKYPIEAIKVLNKVAKVADEHYEEFG-DRVCLEVE-----SIDEG 337

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           +  ++ +    LN K ++TPT +GRTA+LIS+ +    I   + N R    L   +GV +
Sbjct: 338 LVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVES 397

Query: 428 FCLEEGFDERDIIRLIKGLGLVE-SDDIVLMTEGKPIEKTMGTNSIKIFQI 477
             +EE  D   II   + +   E    I L+T G PI +   TN+IK+  I
Sbjct: 398 CLMEEFDDMEKIINTCREMAKKEIGKGIYLITLGHPIGQKK-TNTIKVESI 447


>sp|P22360|KPYK_EMENI PYRUVATE KINASE (PK) >gi|283342|pir||S27364 pyruvate kinase (EC
           2.7.1.40) - Emericella nidulans
           >gi|168074|gb|AAA33320.1| (M36918) pyruvate kinase
           [Aspergillus nidulans]
           Length = 526
           
 Score =  277 bits (701), Expect = 2e-73
 Identities = 174/472 (36%), Positives = 265/472 (55%), Gaps = 24/472 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDIS-QKLDRRV 68
           +T I+ TIGP T+S   I  L   G++VVR+NFSHGS+E H  VI+  R+   Q   R V
Sbjct: 34  RTSIICTIGPKTNSVEKINALRRAGLNVVRMNFSHGSYEYHQSVIDHAREAEKQAAGRPV 93

Query: 69  AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRD---VVGDETTIPVEYKDFPRLVSK 124
           AI  D  G +IR G   G   + +K G ++ ++T +      D+  + V+YK+  +++S 
Sbjct: 94  AIALDTKGPEIRTGNTVGDKDIPIKAGHEMNISTDEQYATASDDQNMYVDYKNITKVISA 153

Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           G +IY+ DG +   V E V  + +    ++ G + SRKG+N+P   + + A++ +D+  +
Sbjct: 154 GKLIYVDDGILSFEVLEVVDDKTLRVRCLNNGNISSRKGVNLPGTDVDLPALSEKDISDL 213

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           KF ++  VD +  SF+    D+  ++  L + +  ++ +I+KIE    V NFDEIL+ +D
Sbjct: 214 KFGVKNKVDMVFASFIRRGSDIRHIREVLGE-EGREIQIIAKIENQQGVNNFDEILEETD 272

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P  ++ I QK +I K N +GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
           ANA+LDG D VMLS ETA G +P +AV MM++   + E     F +   LR L    T  
Sbjct: 333 ANAVLDGADCVMLSGETAKGNYPCEAVTMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
              E+IA + + A   LN   I+  T +G TAR+IS+++P   I   S N          
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGNTARMISKYRPVCPIIMVSRNPAATRYSHLY 450

Query: 423 YGVYAFCLEE---GFD----ERDIIRLIK-------GLGLVESDDIVLMTEG 460
            GV+ F   E    F+    + D+ R +K        LG++   D ++  +G
Sbjct: 451 RGVWPFYFPEKKPDFNVKIWQEDVDRRLKWGINHGLKLGIINKGDNIVCVQG 502


>gb|AAK41255.1| Pyruvate kinase (pyK) [Sulfolobus solfataricus]
           Length = 452
           
 Score =  276 bits (699), Expect = 3e-73
 Identities = 164/431 (38%), Positives = 254/431 (58%), Gaps = 28/431 (6%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIVAT+GP  SS   +K+L E  V V R+NF+HG    H K  + +R  + +     +
Sbjct: 3   KTKIVATLGP--SSEEKVKELAEY-VDVFRINFAHGDETSHRKYFDLIRTYAPES----S 55

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           I+ DLPG K+R+GE+K   +E+K+G+K+V + +D       IPV+ + F   V +   I 
Sbjct: 56  IIVDLPGPKLRLGELKEP-IEVKKGDKIVFSQKD------GIPVDDELFYSAVKENSDIL 108

Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
           ++DG I +RV+      VE  V+ GG L SRKGINIP   L    +T  D++++K A++ 
Sbjct: 109 IADGTIRVRVKSKAKDRVEGTVIEGGILLSRKGINIPNVNLK-SGITDNDLKLLKRALDL 167

Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
           G D IGLSFV S  DV KVK F+     ++ +VI+KIE+ +A++N   I+  SDGIM+AR
Sbjct: 168 GADYIGLSFVISENDVKKVKEFV----GDEAWVIAKIEKSEALKNLTNIVNESDGIMVAR 223

Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
           GDLGVE  +E LP++Q+ ++R +   GKPVI ATQ+L SM    +PTRAE+ D++N+I+ 
Sbjct: 224 GDLGVETGLENLPLIQRRIVRTSRVFGKPVILATQVLTSMINSPIPTRAEIIDISNSIMQ 283

Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
           G D++MLS+ETAIG +P+++V+ +  I    E+  +   +         G   +  +AIA
Sbjct: 284 GVDSIMLSDETAIGNYPVESVRTLHNIISNVEKSVKHRPI---------GPLNSESDAIA 334

Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
            + ++A        I+  +R+G +   +SR +P++ I G S + R+       YGV    
Sbjct: 335 LAAVNASKVSKADVIVVYSRSGNSILRVSRLRPERNIIGVSPDPRLAKKFKLCYGVIPIS 394

Query: 430 LEEGFDERDII 440
           + +     D I
Sbjct: 395 INKKMQSIDEI 405


>pir||S26869 pyruvate kinase (EC 2.7.1.40) pkiA - Aspergillus niger
           Length = 526
           
 Score =  275 bits (696), Expect = 7e-73
 Identities = 170/472 (36%), Positives = 269/472 (56%), Gaps = 24/472 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQ-KLDRRV 68
           +T I+ TIGP T+S   I  L   G++VVR+NFSHGS+E H  VI+  R+ ++ ++ R +
Sbjct: 34  RTSIIGTIGPKTNSVEKINSLRTAGLNVVRMNFSHGSYEYHQSVIDNAREAAKTQVGRPL 93

Query: 69  AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRD---VVGDETTIPVEYKDFPRLVSK 124
           AI  D  G +IR G       + +K+G ++ +TT +      D+  + ++YK+  +++S 
Sbjct: 94  AIALDTKGPEIRTGNTPDDKDIPIKQGHELNITTDEQYATASDDKNMYLDYKNITKVISP 153

Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           G +IY+ DG +   V E V  + +    ++ G + SRKG+N+P   + + A++ +D+  +
Sbjct: 154 GKLIYVDDGILSFEVLEVVDDKTIRVRCLNNGNISSRKGVNLPGTDVDLPALSEKDIADL 213

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           KF +   VD +  SF+    D+  ++  L + + +++ +I+KIE    V NFDEIL+ +D
Sbjct: 214 KFGVRNKVDMVFASFIRRGSDIRHIREVLGE-EGKEIQIIAKIENQQGVNNFDEILEETD 272

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P  ++ I QK +I K N +GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
           ANA+LDG D VMLS ETA G +P +AVKMM++   + E     F +   LR L    T  
Sbjct: 333 ANAVLDGADCVMLSGETAKGNYPNEAVKMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
              E+IA + + A   LN   I+  T +G+TAR +S+++P   I   + N          
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGKTARYLSKYRPVCPIVMVTRNPAASRYSHLY 450

Query: 423 YGVYAFCLEE---GFD----ERDIIRLIK-------GLGLVESDDIVLMTEG 460
            GV+ F   E    F+    + D+ R +K        LG++   D ++  +G
Sbjct: 451 RGVWPFLFPEKKPDFNVKVWQEDVDRRLKWGINHALKLGIINKGDNIVCVQG 502


>sp|Q12669|KPYK_ASPNG PYRUVATE KINASE (PK) >gi|250607|gb|AAB22392.1| (S38698) pyruvate
           kinase {EC 2.7.1.40} [Aspergillus niger, N402, Peptide,
           526 aa]
           Length = 526
           
 Score =  274 bits (693), Expect = 2e-72
 Identities = 169/472 (35%), Positives = 269/472 (56%), Gaps = 24/472 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQ-KLDRRV 68
           +T I+ TIGP T+S   I  L   G++VVR+NFSHGS++ H  VI+  R+ ++ ++ R +
Sbjct: 34  RTSIIGTIGPKTNSVEKINSLRTAGLNVVRMNFSHGSYQYHQSVIDNAREAAKTQVGRPL 93

Query: 69  AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRD---VVGDETTIPVEYKDFPRLVSK 124
           AI  D  G +IR G       + +K+G ++ +TT +      D+  + ++YK+  +++S 
Sbjct: 94  AIALDTKGPEIRTGNTPDDKDIPIKQGHELNITTDEQYATASDDKNMYLDYKNITKVISP 153

Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           G +IY+ DG +   V E V  + +    ++ G + SRKG+N+P   + + A++ +D+  +
Sbjct: 154 GKLIYVDDGILSFEVLEVVDDKTIRVRCLNNGNISSRKGVNLPGTDVDLPALSEKDIADL 213

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           KF +   VD +  SF+    D+  ++  L + + +++ +I+KIE    V NFDEIL+ +D
Sbjct: 214 KFGVRNKVDMVFASFIRRGSDIRHIREVLGE-EGKEIQIIAKIENQQGVNNFDEILEETD 272

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P  ++ I QK +I K N +GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
           ANA+LDG D VMLS ETA G +P +AVKMM++   + E     F +   LR L    T  
Sbjct: 333 ANAVLDGADCVMLSGETAKGNYPNEAVKMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
              E+IA + + A   LN   I+  T +G+TAR +S+++P   I   + N          
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGKTARYLSKYRPVCPIVMVTRNPAASRYSHLY 450

Query: 423 YGVYAFCLEE---GFD----ERDIIRLIK-------GLGLVESDDIVLMTEG 460
            GV+ F   E    F+    + D+ R +K        LG++   D ++  +G
Sbjct: 451 RGVWPFLFPEKKPDFNVKVWQEDVDRRLKWGINHALKLGIINKGDNIVCVQG 502


>dbj|BAB10461.1| (AB005234) pyruvate kinase [Arabidopsis thaliana]
           Length = 510
           
 Score =  274 bits (693), Expect = 2e-72
 Identities = 163/402 (40%), Positives = 242/402 (59%), Gaps = 15/402 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  MI+KL++ G++V R NFSHGS E H + ++ +R   Q      A
Sbjct: 21  KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAA 80

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  ++LK G+++ +TT  D+ GDE TI + YK  P  V  G+ 
Sbjct: 81  VMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNT 140

Query: 128 IYLSDGYIVLRVE--EVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-IIK 184
           I  +DG I L V   +     V     +   L  RK +N+P   + +  +T +D+E I+K
Sbjct: 141 ILCADGSISLAVVSCDPNAGTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVEDILK 200

Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
           + +   +D I LSFV    D++ V+  L  + ++ + ++SK+E  + V NFDEIL+ +D 
Sbjct: 201 WGVPNNIDMIALSFVRKGSDLVNVRKVLGSH-SKSIMLMSKVENQEGVLNFDEILRETDA 259

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
            M+ARGDLG+E+PIE++ + QK +I K N  GKPV+TATQML SM     PTRAE TDVA
Sbjct: 260 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 319

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVE-DGT 360
           NA+LDGTD VMLS E+A G +P  AVK MAKI   A+ + +Y   F     +E++     
Sbjct: 320 NAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIF-----KEMIRATPL 374

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
             +  E++A S +        K I+  TR G TA+L+++++P
Sbjct: 375 PMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRP 416


>sp|O65595|KPYC_ARATH PROBABLE PYRUVATE KINASE, CYTOSOLIC ISOZYME (PK)
           >gi|7434442|pir||T05065 pyruvate kinase (EC 2.7.1.40) -
           Arabidopsis thaliana >gi|2982467|emb|CAA18231.1|
           (AL022223) pyruvate kinase like protein [Arabidopsis
           thaliana] >gi|7269491|emb|CAB79494.1| (AL161565)
           pyruvate kinase like protein [Arabidopsis thaliana]
           Length = 497
           
 Score =  272 bits (689), Expect = 5e-72
 Identities = 164/402 (40%), Positives = 246/402 (60%), Gaps = 15/402 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  M++KL+  G+SV R NFSHGS+E H + ++ +R          A
Sbjct: 8   KTKIVCTLGPASRSVPMVEKLLMAGMSVARFNFSHGSYEYHQETLDNLRQAMLNTGMLCA 67

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  ++LK+G+++ ++T  D+ GDE TI + YK   + V+ G V
Sbjct: 68  VMLDTKGPEIRTGFLKDGKPIQLKQGQEITISTDYDLKGDEKTICMSYKKLAQDVNPGMV 127

Query: 128 IYLSDGYIVLRV---EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRD-MEII 183
           I  +DG I L+V   ++ +G  V     +   L  RK +N+P   + +  +T +D  +I+
Sbjct: 128 ILCADGTISLKVLSCDKEKGT-VRCRCENTSMLGERKNVNLPGVVVDLPTLTEKDKQDIL 186

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           ++ +   +D I LSFV    D+++V+  L K+ A+ + ++SK+E  + V NFD+IL  SD
Sbjct: 187 EWGVPNQIDMIALSFVRKGSDLVQVRKLLGKH-AKTILLMSKVENQEGVANFDDILINSD 245

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
             MIARGDLG+E+PIE++ + QK +I K N  GKPV+TATQML SM     PTRAE TDV
Sbjct: 246 AFMIARGDLGMEIPIEKIFLAQKVMIYKCNFMGKPVVTATQMLESMIKSPRPTRAEATDV 305

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVEDGT 360
           ANA+LDGTD VMLS ETA G +P  AV+ MAKI   A+ T +Y + F    L   V    
Sbjct: 306 ANAVLDGTDCVMLSGETAAGAYPELAVRTMAKICVEAESTLDYGDIFKRIMLHAAVPMSP 365

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
             ++  +  R+   +  TL    ++  TR G TARL+++++P
Sbjct: 366 MESLASSAVRTATSSRATL----MMVLTRGGSTARLVAKYRP 403


>gb|AAF81342.1|AC007767_22 (AC007767) Strong similarity to a pyruvate kinase isozyme G,
           chloroplast precursor from Nicotiana tabacum gb|Z28374. 
           It contains a pyruvate kinase domain PF|00224.  EST
           gb|AI996399 comes from this gene. [Arabidopsis thaliana]
           Length = 567
           
 Score =  272 bits (689), Expect = 5e-72
 Identities = 173/475 (36%), Positives = 266/475 (55%), Gaps = 18/475 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK-LDRRV 68
           KTKIV TIGP++SSR MI KL E G++V RLN SHG    H   I+ V++ +   +D+ +
Sbjct: 100 KTKIVCTIGPSSSSREMIWKLAEAGMNVARLNMSHGDHASHQITIDLVKEYNSLFVDKAI 159

Query: 69  AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
           AI+ D  G ++R G++    + L+ G++   T +  V  + T+ V Y DF   V  GD++
Sbjct: 160 AIMLDTKGPEVRSGDVPQP-IFLEEGQEFNFTIKRGVSLKDTVSVNYDDFVNDVEVGDIL 218

Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
            +  G + L V+      V+ VV+ GG+L SR+ +N+      + ++T +D E IKF ++
Sbjct: 219 LVDGGMMSLAVKSKTSDLVKCVVIDGGELQSRRHLNVRGKSATLPSITDKDWEDIKFGVD 278

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
             VD   +SFV     V ++K++L+     ++ VI KIE  D+++N   I+ A DG M+A
Sbjct: 279 NQVDFYAVSFVKDAKVVHELKNYLK-----NISVIVKIESADSIKNLPSIISACDGAMVA 333

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLG E+PIE +P+LQ+E+IR+  +  KPVI AT ML SM     PTRAEV+D+A A+ 
Sbjct: 334 RGDLGAELPIEEVPLLQEEIIRRCRSIHKPVIVATNMLESMINHPTPTRAEVSDIAIAVR 393

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           +G DA+MLS ETA GKFP+ AV +M  +A  TE        S  R     G  G +    
Sbjct: 394 EGADAIMLSGETAHGKFPLKAVNVMHTVALRTEA-SLPVRTSASRTTAYKGHMGQMFAFH 452

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
           A  + + L +  I +    TRTG  A L+S ++P   IF F+   R+   L    GV   
Sbjct: 453 ASIMANTLSSPLIVF----TRTGSMAVLLSHYRPSATIFAFTNQRRIMQRLALYQGVMPI 508

Query: 429 CLEEGFDERDI----IRLIKGLGLV-ESDDIVLMTEG-KPIEKTMGTNSIKIFQI 477
            +E   D  D     ++L++   ++ E   + L+  G +PI +   T+ I++ +I
Sbjct: 509 YMEFSDDAEDTYARSLKLLQDENMLKEGQHVTLVQSGSQPIWREESTHLIQVRKI 563


>dbj|BAB10006.1| (AB006697) pyruvate kinase [Arabidopsis thaliana]
           Length = 510
           
 Score =  272 bits (688), Expect = 6e-72
 Identities = 165/407 (40%), Positives = 243/407 (59%), Gaps = 17/407 (4%)

Query: 5   RLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL 64
           R+P  KTKIV T+GPA+ + +MI+KL++ G++V R NFSHGS E H + ++ +R      
Sbjct: 18  RIP--KTKIVCTLGPASRTVSMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRSAMHNT 75

Query: 65  DRRVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLV 122
               A++ D  G +IR G +K G  ++LK G+++ +TT  D+ GDE+TI + YK  P  V
Sbjct: 76  GILAAVMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIQGDESTISMSYKKLPLDV 135

Query: 123 SKGDVIYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
             G+ I  +DG I L V     +   V     +   L  RK +N+P   + +  +T +D+
Sbjct: 136 KPGNTILCADGSISLAVLSCDPESGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTDKDI 195

Query: 181 E-IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEIL 239
           E I+ + +   +D I LSFV    D++ V+  L  + A+ + ++SK+E  + V NFDEIL
Sbjct: 196 EDILGWGVPNSIDMIALSFVRKGSDLVNVRKVLGSH-AKSIMLMSKVENQEGVINFDEIL 254

Query: 240 KASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAE 299
           + +D  M+ARGDLG+E+PIE++ + QK +I K N  GKPV+TATQML SM     PTRAE
Sbjct: 255 RETDAFMVARGDLGMEIPIEKIFLAQKLMIYKCNLAGKPVVTATQMLESMIKSPRPTRAE 314

Query: 300 VTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESF-GMSRLREL 355
            TDVANA+LDGTD VMLS E+A G +P  AVK+MAKI   A+ + +Y   F  M R   L
Sbjct: 315 ATDVANAVLDGTDCVMLSGESAAGAYPEIAVKVMAKICIEAESSLDYNTIFKEMIRATPL 374

Query: 356 VEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
                     E++A S +        K I+  TR G TA L+++++P
Sbjct: 375 PMSPL-----ESLASSAVRTANKARAKLIIVLTRGGSTANLVAKYRP 416


>sp|O62619|KPYK_DROME PYRUVATE KINASE (PK) >gi|3108349|gb|AAC15808.1| (AF061507) pyruvate
           kinase [Drosophila melanogaster]
           >gi|3128475|gb|AAC16244.1| (AF062478) pyruvate kinase
           [Drosophila melanogaster]
           Length = 533
           
 Score =  272 bits (687), Expect = 8e-72
 Identities = 159/405 (39%), Positives = 244/405 (59%), Gaps = 19/405 (4%)

Query: 13  IVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVR----DISQKL--DR 66
           IV TIGPA+SS  M++K++  G+++ R+NFSHGS E HA  +  VR    + S KL  + 
Sbjct: 50  IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEH 109

Query: 67  RVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
            VAI  D  G +IR G I G     +ELK+GEK+ LTT     ++ ++ + Y D+  +V+
Sbjct: 110 PVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVN 169

Query: 124 ---KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
               G+ ++++DG I L V EV    +   V +GG L SRKG+N+P   + + AV+ +D 
Sbjct: 170 VVKPGNRVFVNDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDK 229

Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
             + F +EQ VD I  SF+ +   + +++  L +   +++ +ISKIE    + N DEI++
Sbjct: 230 SDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEK-GKNIKIISKIENQQGMHNLDEIIE 288

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
           A DGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRAE+
Sbjct: 289 AGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEI 348

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE--YRESFGMSRLRELVED 358
           +DVANA+LDG D VMLS ETA G++P++ V  MAK  K  E   + ++F      +LV  
Sbjct: 349 SDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNF----FNDLVRG 404

Query: 359 GTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPK 403
                   A A + ++A        I+  T +G++A  +S+++P+
Sbjct: 405 AGTIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPR 449


>emb|CAA66194.1| (X97579) pyruvate kinase [Agaricus bisporus]
           Length = 532
           
 Score =  272 bits (687), Expect = 8e-72
 Identities = 162/432 (37%), Positives = 245/432 (56%), Gaps = 14/432 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI--SQKLDRR 67
           KT I+ATIGP  ++   +  +   GV++VR+NFSHG+ E H  VI+  R +  +    R 
Sbjct: 34  KTAIIATIGPKINTVEKLTDVRLAGVNIVRMNFSHGTHEYHQSVIDNTRQMIKNDPHGRP 93

Query: 68  VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDV---VGDETTIPVEYKDFPRLVS 123
           VAI  D  G +IR G+ + G    +K G++ ++TT      + D   + V+Y +   + +
Sbjct: 94  VAIALDTKGPEIRTGQTRDGNDYPIKAGDEFIVTTDPKYSDICDNKVLFVDYANLASVTA 153

Query: 124 KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
            G +IY+ DG I L +  + G ++    ++ G L SRKG+N+PK  + +  ++ +D + +
Sbjct: 154 PGKLIYIDDGIISLLILSIDGMNLHVRALNNGTLSSRKGVNLPKTDVDLPPLSEKDKDDL 213

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           +F I  GVD I  SF+    DV +++  L   D   + +I KIE    V NFDEILK +D
Sbjct: 214 RFGIRNGVDMIFASFIRRGEDVRQIREVLGP-DGASIKIIVKIENEQGVANFDEILKEAD 272

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P  ++ + QK +I K N  GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPASQVFLAQKMMIAKCNIVGKPVIVATQMLESMTYNPRPTRAEVSDV 332

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGT 360
           ANA+LDG+D VMLS ETA G +P+ +V MMA+   + E    Y   +   R  +     T
Sbjct: 333 ANAVLDGSDCVMLSGETAKGSYPVQSVLMMAETCLLAETAICYPPLYDDLRAVQARPTET 392

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
                E +A + + A    + K +L  + +G TARL+S+++PK  I   + NE+    + 
Sbjct: 393 ----AETVAIAAVAAAAEQDAKALLVLSTSGETARLVSKYRPKIPIITVTRNEQTARQIH 448

Query: 421 FSYGVYAFCLEE 432
              G Y F   E
Sbjct: 449 LHRGCYPFWYPE 460


>emb|CAA62560.1| (X91106) pyruvate kinase [Agaricus bisporus]
           Length = 530
           
 Score =  272 bits (687), Expect = 8e-72
 Identities = 162/432 (37%), Positives = 245/432 (56%), Gaps = 14/432 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI--SQKLDRR 67
           KT I+ATIGP  ++   +  +   GV++VR+NFSHG+ E H  VI+  R +  +    R 
Sbjct: 32  KTAIIATIGPKINTVEKLTDVRLAGVNIVRMNFSHGTHEYHQSVIDNTRQMIKNDPHGRP 91

Query: 68  VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDV---VGDETTIPVEYKDFPRLVS 123
           VAI  D  G +IR G+ + G    +K G++ ++TT      + D   + V+Y +   + +
Sbjct: 92  VAIALDTKGPEIRTGQTRDGNDYPIKAGDEFIVTTDPKYSDICDNKVLFVDYANLASVTA 151

Query: 124 KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
            G +IY+ DG I L +  + G ++    ++ G L SRKG+N+PK  + +  ++ +D + +
Sbjct: 152 PGKLIYIDDGIISLLILSIDGMNLHVRALNNGTLSSRKGVNLPKTDVDLPPLSEKDKDDL 211

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           +F I  GVD I  SF+    DV +++  L   D   + +I KIE    V NFDEILK +D
Sbjct: 212 RFGIRNGVDMIFASFIRRGEDVRQIREVLGP-DGASIKIIVKIENEQGVANFDEILKEAD 270

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P  ++ + QK +I K N  GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 271 GVMVARGDLGIEIPASQVFLAQKMMIAKCNIVGKPVIVATQMLESMTYNPRPTRAEVSDV 330

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGT 360
           ANA+LDG+D VMLS ETA G +P+ +V MMA+   + E    Y   +   R  +     T
Sbjct: 331 ANAVLDGSDCVMLSGETAKGSYPVQSVLMMAETCLLAETAICYPPLYDDLRAVQARPTET 390

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
                E +A + + A    + K +L  + +G TARL+S+++PK  I   + NE+    + 
Sbjct: 391 ----AETVAIAAVAAAAEQDAKALLVLSTSGETARLVSKYRPKIPIITVTRNEQTARQIH 446

Query: 421 FSYGVYAFCLEE 432
              G Y F   E
Sbjct: 447 LHRGCYPFWYPE 458


>gb|AAG18902.1| (AE004992) pyruvate kinase; PykA [Halobacterium sp. NRC-1]
           Length = 579
           
 Score =  272 bits (687), Expect = 8e-72
 Identities = 174/476 (36%), Positives = 256/476 (53%), Gaps = 24/476 (5%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           KIV T+GPAT+    ++ L + G++V R+N SHG      ++IE  R +  + D+ +A++
Sbjct: 5   KIVCTLGPATNDDASVRALADAGMTVARINASHGDAAARRELIETTRAVDAQTDKPLAVM 64

Query: 72  ADLPGLKIRVGEIKG-GYVELKRGEKVVLT-----TRDVVGDETTIPVEYKDFPRLVSKG 125
            D  G ++R   I   G + ++ G  V        T D +G  T+I             G
Sbjct: 65  LDTQGPEVRTAPIDDDGTIHIETGSDVAFVEGDTATPDRIGISTSIAA--------AEPG 116

Query: 126 DVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
           D + L DG I   V+ V G  V A VVSGG L SRKG+N+P   L V+ VT +D   +  
Sbjct: 117 DTVLLDDGRIEADVDRVAGDTVHATVVSGGSLGSRKGVNVPGVELDVDVVTEKDRRDLAL 176

Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGI 245
           A E  VD +  SFV    DVL V   LE + A D+ +++KIER  AV N D I+ A+ G+
Sbjct: 177 AAELDVDYVAASFVRDADDVLAVNRVLESHGA-DIPIVAKIERAGAVENLDGIIDAAQGV 235

Query: 246 MIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVAN 305
           M+ARGDLGVE P+E +P++QK +I +    G PVITAT+ML SM   + PTRAE +DVAN
Sbjct: 236 MVARGDLGVECPMEDVPMIQKRIIAQCRDAGVPVITATEMLDSMVHARRPTRAEASDVAN 295

Query: 306 AILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIK 365
           A+LDGTD VMLS ETA+G  P   V+ M +I +  E   E            DGT  T  
Sbjct: 296 AVLDGTDGVMLSAETAVGDNPTRVVETMDRIVREVEGSAEYSERQEQAVPTADGTAKT-- 353

Query: 366 EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV 425
           +A+ARS       ++   ++  + +G TAR  ++F+P   +   + +  V   L  ++GV
Sbjct: 354 DALARSARYLARDIDASAVVVASESGYTARKAAKFRPSVPVVCATPSHDVRRQLALNWGV 413

Query: 426 YA--FCLEEGFDERDIIRLIKGL---GLVESDDIVLMTEG--KPIEKTMGTNSIKI 474
           +A    + EG     + R ++     G+V S D V++  G    +E    TN++K+
Sbjct: 414 HANYAAVAEGDATTVVERAVQAAVDSGVVASGDTVVVLVGMMTELEGASTTNTLKV 469


>gb|AAC28104.1| (AF079586) pyruvate kinase; PK [Zymomonas mobilis]
           Length = 475
           
 Score =  271 bits (686), Expect = 1e-71
 Identities = 158/471 (33%), Positives = 252/471 (52%), Gaps = 11/471 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           K ++V+T+GPA+S+   I+     G  V R+N SHG+ +E   +++ +R + ++ +R   
Sbjct: 11  KVRVVSTLGPASSTAEQIRDRFLAGADVFRINMSHGTHDEKKVIVDNIRALEKEFNRPTT 70

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL DL G K+RVG+ K G V+LK G+         +GDET + + + +  + + KG  + 
Sbjct: 71  ILFDLQGPKLRVGDFKEGKVQLKEGQTFTFDQDPTLGDETRVNLPHPEIFKALDKGHRLL 130

Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
           L DG IV+R  E     +   V   G L   KG N+P   +P+ A+TP+D + + FA+++
Sbjct: 131 LDDGKIVVRCVESSPTKIVTRVEVPGPLSDHKGFNVPDVVIPLAALTPKDRKDLDFALKE 190

Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
             D + LSFV  V DV++ K  ++        ++ K+E+P A+ N + IL A+D +M+AR
Sbjct: 191 KADWVALSFVQRVEDVIEAKELIKGRAP----LLVKLEKPAAIENLESILAATDAVMVAR 246

Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
           GDLGVE   E +P  QK ++ ++   GKPV+ AT ML SM     PTRAEV+DVANAI +
Sbjct: 247 GDLGVECLPESVPPTQKRIVERSRQLGKPVVVATAMLESMIKAPAPTRAEVSDVANAIYE 306

Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
           G D +MLS E+A G +P +AV MM +IA   E    + G              T  +A+A
Sbjct: 307 GADGIMLSAESAAGDWPHEAVNMMHRIASYVE---NAPGYIERVRFTPTPAEPTTVDALA 363

Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
            +      T+  K I+  T TG+TA+ +SR +P   I   + +  V   L   +G     
Sbjct: 364 ENASKTAETVGAKAIIVFTETGKTAQRVSRARPVAPILSLTPDAEVARRLGLVWGAQPVQ 423

Query: 430 LE--EGFDERDII--RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQ 476
           +   +  DE   +     K  G  ++ D +++  G+P  K   TN + + +
Sbjct: 424 VSTVKTLDEAKKLAAETAKKYGFAKAGDKLVVVAGEPFGKAGTTNIVDVIE 474


>sp|P30615|KPY1_TRYBB PYRUVATE KINASE 1 (PK 1) >gi|102108|pir||S17648 pyruvate kinase (EC
           2.7.1.40) isoform 1 - Trypanosoma brucei
           >gi|10948|emb|CAA41018.1| (X57950) pyruvate kinase
           [Trypanosoma brucei]
           Length = 499
           
 Score =  271 bits (685), Expect = 1e-71
 Identities = 161/413 (38%), Positives = 244/413 (58%), Gaps = 8/413 (1%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           +IV TIGP+T S   +K L+++G+SV R+NFSHGS E H   I  VR  + +L   + I 
Sbjct: 23  RIVCTIGPSTQSVEALKNLMKSGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHIGIA 82

Query: 72  ADLPGLKIRVGEIKGGYVELKRGEKVVLTTR---DVVGDETTIPVEYKDFPRLVSKGDVI 128
            D  G +IR G  K G V    G+ V +TT    + VG +    ++Y      V  G  I
Sbjct: 83  LDTKGPEIRTGLFKDGEVSFAPGDIVCVTTDPAYEKVGTKEKFYIDYPQLTNAVRPGGSI 142

Query: 129 YLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           Y+ DG + LRV  +   + ++  V +  +L  R+GIN+P   + + AV+ +D + ++F +
Sbjct: 143 YVDDGVMTLRVVSKEDDRTLKCHVNNHHRLTDRRGINLPGCEVDLPAVSEKDRKDLEFGV 202

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
            QGVD I  SF+ +   V +V++ L +   +D+ +ISKIE    V+N D I++AS+GIM+
Sbjct: 203 AQGVDMIFASFIRTAEQVREVRAALGEK-GKDILIISKIENHQGVQNIDSIIEASNGIMV 261

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E++ + Q  +I K N  GKPVI ATQML SMT+   PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPTRAEVSDVANAV 321

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKI-AKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
           L+G D VMLS ETA GK+P + V+ MA+I  +      ++   + ++ L +       +E
Sbjct: 322 LNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSIKNLQK--IPMCPEE 379

Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
           A+  S + +   +  K +L  + TGR+ARLIS+++P   I   +T  + C  L
Sbjct: 380 AVCSSAVASAFEVQAKAMLVLSNTGRSARLISKYRPNCPIICVTTRLQTCRQL 432


>sp|P30616|KPY2_TRYBB PYRUVATE KINASE 2 (PK 2) >gi|102107|pir||S17649 pyruvate kinase (EC
           2.7.1.40) isoform 2 - Trypanosoma brucei
           >gi|10950|emb|CAA41019.1| (X57951) pyruvate kinase
           [Trypanosoma brucei]
           Length = 499
           
 Score =  271 bits (685), Expect = 1e-71
 Identities = 161/413 (38%), Positives = 245/413 (58%), Gaps = 8/413 (1%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           +IV TIGP+T S   +K L+++G+SV R+NFSHGS E H   I  VR  + +L   + I 
Sbjct: 23  RIVCTIGPSTQSVEALKNLMKSGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHIGIA 82

Query: 72  ADLPGLKIRVGEIKGGYVELKRGEKVVLTTR---DVVGDETTIPVEYKDFPRLVSKGDVI 128
            D  G +IR G  K G V    G+ V +TT    + VG +    ++Y    + V  G  I
Sbjct: 83  LDTKGPEIRTGLFKDGEVTFAPGDIVCVTTDPAYEKVGTKEKFYIDYPQLTKAVPVGGSI 142

Query: 129 YLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           Y+ DG + LRV  +   + ++  V +  +L  R+GIN+P   + + AV+ +D + ++F +
Sbjct: 143 YVDDGVMTLRVLSKEDDRTLKCHVNNHHRLTDRRGINLPGCEVDLPAVSEKDRKDLEFGV 202

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
            QGVD I  SF+ +   V +V++ L +   +D+ +ISKIE    V+N D I++AS+GIM+
Sbjct: 203 AQGVDMIFASFIRTAEQVREVRAALGEK-GKDILIISKIENHQGVQNIDSIIEASNGIMV 261

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLGVE+P E++ + Q  +I K N  GKPVI ATQML SMT+   PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPTRAEVSDVANAV 321

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKI-AKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
           L+G D VMLS ETA GK+P + V+ MA+I  +      ++   + ++ L +       +E
Sbjct: 322 LNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSIKNLQK--IPMCPEE 379

Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
           A+  S + +   +  K +L  + TGR+ARLIS+++P   I   +T  + C  L
Sbjct: 380 AVCSSAVASAFEVQAKAMLVLSNTGRSARLISKYRPNCPIICVTTRLQTCRQL 432


>sp|P43924|KPYK_HAEIN PYRUVATE KINASE (PK) >gi|1075198|pir||C64130 pyruvate kinase (EC
           2.7.1.40) - Haemophilus influenzae  (strain Rd KW20)
           >gi|1574410|gb|AAC23216.1| (U32831) pyruvate kinase,
           type II (pykA) [Haemophilus influenzae Rd]
           Length = 478
           
 Score =  271 bits (685), Expect = 1e-71
 Identities = 183/461 (39%), Positives = 264/461 (56%), Gaps = 15/461 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKIV T+GP+T   N ++K+I  G +VVR+NFSHG+ ++H    E+VR I++KL + VA
Sbjct: 7   RTKIVCTMGPSTDRDNNLEKIIAAGANVVRMNFSHGTPDDHIGRAERVRSIAKKLGKTVA 66

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET--TIPVEYKDFPRLVSKGDV 127
           IL DL G KIRV   K G + L  G+K +L      G+ T  ++ ++YK  P+ V  GD+
Sbjct: 67  ILGDLQGPKIRVSTFKDGKIFLNVGDKFILDAELPKGEGTQESVGLDYKTLPQDVVPGDI 126

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG + L+V    G  V   V  GG L + KGIN     L  +A+T +D   I  A 
Sbjct: 127 LLLDDGRVQLKVLSTDGAKVFTEVTVGGPLSNNKGINKLGGGLSADALTEKDKADIITAA 186

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
             GVD + +SF  S  D+   +  L +    +  +++K+ER + V N    D+I+ ASD 
Sbjct: 187 RIGVDFLAVSFPRSSADLNYARE-LAQQAGLNAKIVAKVERAETVANDEAMDDIILASDV 245

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           IM+ARGDLGVE+    L  +QK+LIR++    + VITATQM+ SM +  +PTRAEV DVA
Sbjct: 246 IMVARGDLGVEIGDPELVGVQKKLIRRSRQLNRAVITATQMMESMISNPMPTRAEVMDVA 305

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
           NA+LDGTDAVMLS ETA G++P + V  MA +  +  E   S  +SR R    D    TI
Sbjct: 306 NAVLDGTDAVMLSAETAAGQYPSETVAAMASVC-LGAEKMPSINVSRHR---MDKEFETI 361

Query: 365 KEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
           +E++A S + A   +  +  I+T + TGRT  L+SR      IF  S N+   N      
Sbjct: 362 EESVAMSAMYAANHMKGVAAIVTLSSTGRTPLLMSRISSGLPIFALSRNQETLNLCALYR 421

Query: 424 GVY-AFCLEEGFDE---RDIIRLIKGLGLVESDDIVLMTEG 460
           GV   +  EE   E   +   + +K  G + + D+VL+T+G
Sbjct: 422 GVTPIYHGEESRTEAGAKAAPQSLKEKGYLSTGDLVLVTQG 462


>gb|AAF55979.1| (AE003738) PyK gene product [Drosophila melanogaster]
           Length = 533
           
 Score =  271 bits (685), Expect = 1e-71
 Identities = 158/403 (39%), Positives = 241/403 (59%), Gaps = 15/403 (3%)

Query: 13  IVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVR----DISQKL--DR 66
           IV TIGPA+SS  M++K++  G+++ R+NFSHGS E HA  +  VR    + S KL  + 
Sbjct: 50  IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEH 109

Query: 67  RVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
            VAI  D  G +IR G I G     +ELK+GEK+ LTT     ++ ++ + Y D+  +V+
Sbjct: 110 PVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVN 169

Query: 124 ---KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
               G+ +++ DG I L V EV    +   V +GG L SRKG+N+P   + + AV+ +D 
Sbjct: 170 VVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDK 229

Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
             + F +EQ VD I  SF+ +   + +++  L +   +++ +ISKIE    + N DEI++
Sbjct: 230 SDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEK-GKNIKIISKIENQQGMHNLDEIIE 288

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
           A DGIM+ARGDLG+E+P E++ + QK +I + N  GKPVI ATQML SM  +  PTRAE+
Sbjct: 289 AGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEI 348

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
           +DVANA+LDG D VMLS ETA G++P++ V  MAK  K  E     +  +   +LV    
Sbjct: 349 SDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAE--AALWHQNLFNDLVRGAG 406

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPK 403
                 A A + ++A        I+  T +G++A  +S+++P+
Sbjct: 407 TIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPR 449


>sp|P57404|KPYK_BUCAI PYRUVATE KINASE (PK) >gi|10038993|dbj|BAB13027.1| (AP001119)
           pyruvate kinase [Buchnera sp. APS]
           Length = 480
           
 Score =  271 bits (685), Expect = 1e-71
 Identities = 185/478 (38%), Positives = 268/478 (55%), Gaps = 15/478 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKIVAT+GP+T   N ++K+I +GV+V+R NFSHGS +EH     + R+I  +L+  +A
Sbjct: 7   RTKIVATLGPSTDINNNLEKIIRSGVNVLRFNFSHGSKDEHKSRANQAREIMTRLNFHIA 66

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDV 127
           +L DL G KIR+ +     + L  G+  +L        G++  + ++YK  P  +  GDV
Sbjct: 67  LLGDLQGPKIRISKFIKNNIFLNVGDFFILDANLDQNNGNQERVGIDYKQLPYDLKVGDV 126

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG I L+V +  G ++   VV GG L + KGIN     L  +A+T +D + I  A 
Sbjct: 127 LLLDDGRIQLKVIKSTGHEILTKVVIGGILSNNKGINKLGGGLSADALTEKDKKDIILAT 186

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
           E  VD + +SF     D+ + +  L K    +  +I+KIER +AV N    ++I+ ASD 
Sbjct: 187 EINVDYLAISFPRCSNDLKQARK-LAKEFGSNAKIIAKIERAEAVLNQNTIEDIILASDA 245

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           IMIARGDLGVE+    L  +QK+LIR A    + VITATQM+ SM    +PTRAEV DVA
Sbjct: 246 IMIARGDLGVEIGDSELAGIQKKLIRTARQLNRIVITATQMMESMITNPLPTRAEVMDVA 305

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
           NA+LDG+DAVMLS ETA G++P + V  MAKI K  E+   S  +SR R          I
Sbjct: 306 NAVLDGSDAVMLSAETASGEYPAETVIKMAKICKGAEKV-PSINVSRHR---IHAKFDDI 361

Query: 365 KEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
           +EAIA S +     L  I  I+T T +G+TA + SR      IF  S N+   N      
Sbjct: 362 EEAIAMSAMYVANHLKGITAIITMTESGKTALMTSRITSGLPIFALSKNKETLNLASLYR 421

Query: 424 GV---YAFCLEEGFD-ERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
           GV   Y       F    + I L++  G +   ++V++T+G  + K   TN+ +I ++
Sbjct: 422 GVTPIYFNSKNNNFKAANEAIVLLRKRGFLCRGELVIITQGDIMGKIGKTNTSRILKV 479


>sp|O05118|KPYK_METEX PYRUVATE KINASE (PK) >gi|1907336|gb|AAB66498.1| (U87316) pyruvate
           kinase [Methylobacterium extorquens]
           Length = 483
           
 Score =  270 bits (684), Expect = 2e-71
 Identities = 169/470 (35%), Positives = 257/470 (53%), Gaps = 13/470 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKIVAT+GPA+ +  MI+KL   G  V R+N SH + E+  + IE +R I ++  R + 
Sbjct: 11  RTKIVATLGPASDTPEMIEKLFHAGADVFRINMSHLAREKLPERIEVIRTIEREGKRPIG 70

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           IL DL G K+R+G   G    L+ G+  VL +    GD   + + + +    +     I 
Sbjct: 71  ILVDLQGPKLRLGTFVGDAAVLENGQTFVLDSDPTPGDTDRVFLPHPEILSALEPSHGIL 130

Query: 130 LSDGYIVLRVEEV-RGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
           + DG + L V EV  G+ V  V V GG++ +RKG+++P   LPV A+T +D   ++  + 
Sbjct: 131 IDDGKLRLIVTEVSEGRAVTRVEV-GGRISNRKGVSLPHTALPVPAMTEKDRGDLEAGLA 189

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
            G D I +SFV    DV +VK    K  A    V++KIE+P A+   DEI++ SDGIM+A
Sbjct: 190 AGADWIAVSFVQRPEDVAEVK----KVAAGRALVMAKIEKPQALTRLDEIIEISDGIMVA 245

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLGVEMP+E++P +QK + R A   GKPV+ ATQML SM    VPTRAEV+DVA A+ 
Sbjct: 246 RGDLGVEMPLEQVPGVQKRITRVARRLGKPVVVATQMLESMITSPVPTRAEVSDVATAVY 305

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           +G DAVMLS E+A G FP++A+  M +IA+  E     + +   +    + T      A 
Sbjct: 306 EGADAVMLSAESAAGDFPVEAIGTMNRIAEQVERDALYWSILMAQRSEPEPTASDAIAAA 365

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
           A  I++A   L+++ I+  T +G T   ++R +P   +   +        L  ++GV+  
Sbjct: 366 AHQIVEA---LSLRSIMAWTHSGSTVLRLARARPNASVIALTPKRETARRLTMAWGVHPI 422

Query: 429 CLEEGFDERDI----IRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
             ++  D  D+     +        E  D V++  G P      TN ++I
Sbjct: 423 VTKDASDVDDMAFRAAKFAVRERFAEIGDRVIIVAGVPFGIPGATNMVRI 472


>dbj|BAB10440.1| (AB009055) pyruvate kinase [Arabidopsis thaliana]
           Length = 579
           
 Score =  270 bits (683), Expect = 2e-71
 Identities = 168/475 (35%), Positives = 261/475 (54%), Gaps = 13/475 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDIS-QKLDRRV 68
           KTKIV T+GP+T++R MI KL E G++V R+N SHG    H KVI+ V++ + Q  D  +
Sbjct: 111 KTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNTI 170

Query: 69  AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
           AI+ D  G ++R G++    + L  G++   T    V   + + V Y DF   V  GD++
Sbjct: 171 AIMLDTKGPEVRSGDLPQP-IMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDML 229

Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
            +  G +   V+      V+  VV GG+L SR+ +N+      + ++T +D E IKF +E
Sbjct: 230 LVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVE 289

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
             VD   +SFV     V ++K +L+ N   D+ VI KIE  D++ N   I+ ASDG M+A
Sbjct: 290 NKVDFYAVSFVKDAQVVHELKKYLQ-NSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLG E+PIE +PILQ+E+I    + GK VI AT ML SM     PTRAEV+D+A A+ 
Sbjct: 349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVR 408

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           +G DAVMLS ETA GKFP+ A  +M  +A  TE    +     +   +    +  + E  
Sbjct: 409 EGADAVMLSGETAHGKFPLKAAGVMHTVALRTE---ATITSGEMPPNLGQAFKNHMSEMF 465

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
           A        TL    ++  TRTG  A L+S ++P   I+ F+  +++   L    GV   
Sbjct: 466 AYHATMMSNTLGTSTVVF-TRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPI 524

Query: 429 CLEEGFDERD-----IIRLIKGLGLVESDDIVLMTEG-KPIEKTMGTNSIKIFQI 477
            +E   D  +     +  L+K   + + ++I ++  G +PI ++  T++I++ ++
Sbjct: 525 YMEFTDDAEETFANALATLLKQGMVKKGEEIAIVQSGTQPIWRSQSTHNIQVRKV 579


>dbj|BAB11262.1| (AB009049) pyruvate kinase [Arabidopsis thaliana]
           Length = 498
           
 Score =  269 bits (681), Expect = 4e-71
 Identities = 164/401 (40%), Positives = 242/401 (59%), Gaps = 13/401 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  M++KL+  G++V R NFSHGS E H + ++ +           A
Sbjct: 9   KTKIVCTLGPASRSVPMVEKLLRAGMNVARFNFSHGSHEYHQETLDNLHQAMLNTGILCA 68

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  ++LK+G+++ ++T  D+ GDE TI + YK     V+ G V
Sbjct: 69  VMLDTKGPEIRTGFLKDGKPIQLKQGQEITISTDYDLKGDENTICMSYKKLAVDVNPGMV 128

Query: 128 IYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-IIK 184
           I  +DG I L V     ++  V     +   L  RK +N+P   + +  +T +D E I++
Sbjct: 129 ILCADGTISLLVLSCDKENGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDIMQ 188

Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
           + +   +D I LSFV    D+++V+  L K+ A+++ ++SK+E  + V NFD+IL  SD 
Sbjct: 189 WGVPNQIDMIALSFVRKGSDLVQVRKLLGKH-AKNILLMSKVENQEGVANFDDILVNSDA 247

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
            MIARGDLG+E+PIE++ + QK +I K N +GKPV+TATQML SM     PTRAE TDVA
Sbjct: 248 FMIARGDLGMEIPIEKIFLAQKVMIYKCNIQGKPVVTATQMLESMIKSPRPTRAEATDVA 307

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVEDGTR 361
           NA+LDGTD VMLS ETA G +P  AV+ MAKI   A+ T +Y + F    L   V     
Sbjct: 308 NAVLDGTDCVMLSGETAAGAYPELAVRTMAKICVEAESTLDYGDVFKRIMLYSPVPMSPL 367

Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
            ++  +  R+   A  TL    I+  TR G TARL+++++P
Sbjct: 368 ESLASSAVRTANSARATL----IMVLTRGGSTARLVAKYRP 404


>sp|P32044|KPYK_THEAC PYRUVATE KINASE (PK) >gi|10640173|emb|CAC12025.1| (AL445065)
           pyruvate kinase related protein [Thermoplasma
           acidophilum]
           Length = 544
           
 Score =  269 bits (681), Expect = 4e-71
 Identities = 165/468 (35%), Positives = 261/468 (55%), Gaps = 25/468 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIVATIGPA+SS  ++K++I+NG+S+VR+N +H   ++ +K+ + VR I+    R V 
Sbjct: 2   KTKIVATIGPASSSPEIMKQMIDNGLSLVRINSAHADIKDVSKITQMVRSIN----RDVG 57

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
           I+ DL G ++R GE  GG +++  G+  V+    V+ +   +          V  GD I 
Sbjct: 58  IMIDLKGPELRTGEFAGGTLKISSGKDYVMGKDIVLNNMNVLSA--------VQVGDRIL 109

Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
           +SDG +   VE      + A+  + G L  R  +NIP  ++ +  +T RD   I+  I  
Sbjct: 110 MSDGEVSFEVESTDPFTIRAL--NDGVLRDRSRVNIPGRFIELGTITDRDRAFIREGIAD 167

Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
           GVD   LSFV    +V  ++ F+  +   D ++ISKIE    + N +EI+K+SDGIM+AR
Sbjct: 168 GVDFFALSFVQKSENVDSLRDFVIDSGG-DQYIISKIETKSGLDNIEEIVKSSDGIMVAR 226

Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
           GDLGVE+P++ + + QK +I+ A+ +G   I ATQ+L SM     PTRAE++D+ NAI+D
Sbjct: 227 GDLGVELPLKEVVLAQKHIIKTAHEDGDFTIVATQVLESMVNNSSPTRAEISDITNAIID 286

Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
             DA+MLSEE+AIGK+P+ AV+ + +++   E+ + SF  S   +        TI  ++A
Sbjct: 287 NADALMLSEESAIGKYPVQAVRTLKEVSDYVED-KVSFDSSYYFK------GNTIAYSVA 339

Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
           R+       +    I+  T TG T R+IS  +PK  ++  + +E +   L   +GV    
Sbjct: 340 RAAKILSDDIKSDGIVALTHTGSTVRMISSLRPKAMVYAATVSESLARKLNIYFGVLPLH 399

Query: 430 LE---EGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
           +E   E     +I+  I   G       ++MT G P     GTN +K+
Sbjct: 400 MEGNAEDLSFSEIMEYIVRSGRFADGSKLVMTSGDPYFTFGGTNDVKV 447


>gi|6319279 Pyruvate kinase; Cdc19p [Saccharomyces cerevisiae]
           >gi|125609|sp|P00549|KPY1_YEAST PYRUVATE KINASE 1
           >gi|66859|pir||KIBYP pyruvate kinase (EC 2.7.1.40) -
           yeast (Saccharomyces cerevisiae) >gi|3212328|pdb|1A3W|A
           Chain A, Pyruvate Kinase From Saccharomyces Cerevisiae
           Complexed With Fbp, Pg, Mn2+ And K+
           >gi|3212329|pdb|1A3W|B Chain B, Pyruvate Kinase From
           Saccharomyces Cerevisiae Complexed With Fbp, Pg, Mn2+
           And K+ >gi|3212330|pdb|1A3X|A Chain A, Pyruvate Kinase
           From Saccharomyces Cerevisiae Complexed With Pg, Mn2+
           And K+ >gi|3212331|pdb|1A3X|B Chain B, Pyruvate Kinase
           From Saccharomyces Cerevisiae Complexed With Pg, Mn2+
           And K+ >gi|5265|emb|CAA32573.1| (X14400) pyruvate kinase
           (AA 1 - 500) [Saccharomyces cerevisiae]
           >gi|595546|gb|AAC04993.1| (U12980) Cdc19p: pyruvate
           kinase [Saccharomyces cerevisiae]
           Length = 500
           
 Score =  268 bits (679), Expect = 7e-71
 Identities = 164/433 (37%), Positives = 251/433 (57%), Gaps = 16/433 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL--DRR 67
           +T I+ TIGP T++   +  L + G+++VR+NFSHGS+E H  VI+  R  S++L   R 
Sbjct: 20  RTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARK-SEELYPGRP 78

Query: 68  VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVG---DETTIPVEYKDFPRLVS 123
           +AI  D  G +IR G         +    +++ TT D      D+  + V+YK+  +++S
Sbjct: 79  LAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVIS 138

Query: 124 KGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI 182
            G +IY+ DG +  +V E V  + ++   ++ GK+ S KG+N+P   + + A++ +D E 
Sbjct: 139 AGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKED 198

Query: 183 IKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
           ++F ++ GV  +  SF+ +  DVL ++  L +   +DV +I KIE    V NFDEILK +
Sbjct: 199 LRFGVKNGVHMVFASFIRTANDVLTIREVLGEQ-GKDVKIIVKIENQQGVNNFDEILKVT 257

Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
           DG+M+ARGDLG+E+P   +  +QK+LI K+N  GKPVI ATQML SMT    PTRAEV+D
Sbjct: 258 DGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSD 317

Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDG 359
           V NAILDG D VMLS ETA G +PI+AV  MA+ A + E+   Y  ++    +R      
Sbjct: 318 VGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNY--DDMRNCTPKP 375

Query: 360 TRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
           T  T  E +A S + A+     K I+  + +G T RL+S+++P   I   +   R     
Sbjct: 376 TSTT--ETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFS 433

Query: 420 MFSYGVYAFCLEE 432
               GV+ F  E+
Sbjct: 434 HLYRGVFPFVFEK 446


>sp|Q10208|KPYK_SCHPO PYRUVATE KINASE >gi|7493249|pir||T38890 pyruvate kinase (EC
           2.7.1.40) - fission yeast  (Schizosaccharomyces pombe)
           >gi|1184023|emb|CAA93349.1| (Z69380) pyruvate kinase (EC
           2.7.1.40) [Schizosaccharomyces pombe]
           Length = 509
           
 Score =  268 bits (677), Expect = 1e-70
 Identities = 156/408 (38%), Positives = 243/408 (59%), Gaps = 21/408 (5%)

Query: 8   DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDR- 66
           + +T I+ TIGP +++   + KL + G+++VR+NFSHGS+E H  VI+  R  S      
Sbjct: 25  NRRTSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASATNPLF 84

Query: 67  RVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVGD---ETTIPVEYKDFPRLV 122
            +AI  D  G +IR G   GG    +  G +++ TT D   +   +  + ++YK+  +++
Sbjct: 85  PLAIALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVI 144

Query: 123 SKGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
             G +IY+ DG +   V E+V  ++++  V + GK+ S+KG+N+PK  + + A++ +D  
Sbjct: 145 QPGRIIYVDDGILSFTVIEKVDDKNLKVRVNNNGKISSKKGVNLPKTDVDLPALSEKDKA 204

Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
            ++F ++ GVD I  SF+    DV+ ++  L + + +++ +I KIE    V NFD IL  
Sbjct: 205 DLRFGVKNGVDMIFASFIRRAEDVIHIREVLGE-EGKNIKIICKIENQQGVNNFDSILDV 263

Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
           +DGIM+ARGDLG+E+P  ++ + QK +I K N  GKPV  ATQML SMT    PTRAEV+
Sbjct: 264 TDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVS 323

Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE-------YRESFGMSRLRE 354
           DV NA+LDG D VMLS ET  G +P++AV  MA+ A+V E        Y+E FG+  +R 
Sbjct: 324 DVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMFGL--VRR 381

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
            +E  T  T   AI  SI       + K I+  + +G TARL S+++P
Sbjct: 382 PLECATETTAVAAIGASI-----ESDAKAIVVLSTSGNTARLCSKYRP 424


>pir||T45166 pyruvate kinase (EC 2.7.1.40) [imported] - fission yeast
           (Schizosaccharomyces pombe) >gi|1200144|emb|CAA62490.1|
           (X91008) pyruvate kinase [Schizosaccharomyces pombe]
           >gi|1586497|prf||2204219A pyruvate kinase
           [Schizosaccharomyces pombe]
           Length = 509
           
 Score =  267 bits (675), Expect = 2e-70
 Identities = 156/408 (38%), Positives = 243/408 (59%), Gaps = 21/408 (5%)

Query: 8   DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDR- 66
           + +T I+ TIGP +++   + KL + G+++VR+NFSHGS+E H  VI+  R  S      
Sbjct: 25  NRRTSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASATNPLF 84

Query: 67  RVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVGD---ETTIPVEYKDFPRLV 122
            +AI  D  G +IR G   GG    +  G +++ TT D   +   +  + ++YK+  +++
Sbjct: 85  PLAIALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVI 144

Query: 123 SKGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
             G +IY+ DG +   V E+V  ++++  V + GK+ S+KG+N+PK  + + A++ +D  
Sbjct: 145 QPGRIIYVDDGILSFTVIEKVDDKNLKVRVNNNGKISSKKGVNLPKTDVDLPALSEKDKA 204

Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
            ++F ++ GVD I  SF+    DV+ ++  L + + +++ +I KIE    V NFD IL  
Sbjct: 205 DLRFGVKNGVDMIFASFIRRAEDVIHIREVLGE-EGKNIKIICKIENQQGVNNFDSILDV 263

Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
           +DGIM+ARGDLG+E+P  ++ + QK +I K N  GKPV  ATQML SMT    PTRAEV+
Sbjct: 264 TDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVS 323

Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE-------YRESFGMSRLRE 354
           DV NA+LDG D VMLS ET  G +P++AV  MA+ A+V E        Y+E FG+  +R 
Sbjct: 324 DVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMFGL--VRR 381

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
            +E  T  T   AI  SI       + K I+  + +G TARL S+++P
Sbjct: 382 PLECATETTRVAAIGASI-----ESDAKAIVVLSTSGNTARLCSKYRP 424


>gb|AAF05863.1|AC011698_14 (AC011698) putative pyruvate kinase [Arabidopsis thaliana]
           Length = 510
           
 Score =  266 bits (674), Expect = 3e-70
 Identities = 159/399 (39%), Positives = 242/399 (59%), Gaps = 9/399 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  M++KL++ G++V R NFSHGS   H + ++ +R   +      A
Sbjct: 17  KTKIVCTLGPASRSVEMVEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMENTCIPCA 76

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  VEL +G+++ ++T   + GD  TI + YK     +  GDV
Sbjct: 77  VMLDTKGPEIRTGFLKEGKPVELIQGQEITISTDYTMEGDSNTISMSYKKLAEDLKSGDV 136

Query: 128 IYLSDGYI---VLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
           I  SDG I   VL  ++  G  V A   +   L  RK +N+P   + +  +T +D E I+
Sbjct: 137 ILCSDGTISLTVLSCDKNLGL-VRARCENSAVLGERKNVNLPGIVVDLPTLTEKDQEDIL 195

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           ++ +   +D I LSFV    D+++V+  L +N A+ + ++SK+E  + V NFD+IL+ SD
Sbjct: 196 QWGVPNKIDIIALSFVRKGSDLVEVRKLLGEN-AKSIMLMSKVENQEGVMNFDKILEYSD 254

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
             M+ARGDLG+E+PIE++ + QK +I+KAN  GKP++TATQML SMT    PTRAE TDV
Sbjct: 255 AFMVARGDLGMEIPIEKMFLAQKMMIQKANALGKPIVTATQMLESMTKSPRPTRAEATDV 314

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
           ANA+LDGTD VMLS ETA G  P  AV  M++I K  E++ +   M +  + +       
Sbjct: 315 ANAVLDGTDCVMLSGETAAGAHPETAVLTMSRICKEAEDFIDYDTMHKKIQDIVSLPLSP 374

Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
           I E++A S +    +L    I+  T+ G T  L+++++P
Sbjct: 375 I-ESLAASAVSTARSLCAAAIVVLTKGGYTVELVAKYRP 412


>pir||F81684 pyruvate kinase TC0609 [imported] - Chlamydia muridarum  (strain
           Nigg) >gi|7190647|gb|AAF39440.1| (AE002329) pyruvate
           kinase [Chlamydia muridarum]
           Length = 481
           
 Score =  266 bits (673), Expect = 4e-70
 Identities = 159/425 (37%), Positives = 247/425 (57%), Gaps = 4/425 (0%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKI+ TIGPAT++  M++KL++ G++V RLNFSHG+ E H + I  ++++ +K    +A
Sbjct: 4   RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLA 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKD--FPRLVSKGDV 127
           I+ D  G +IR+G+++   +++K G+++ LT+++++G +      Y    FP +  +  V
Sbjct: 64  IMLDTKGPEIRLGQVESP-IKVKPGDRLTLTSKEILGSKEAGVTLYPSCVFPFVRERAPV 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DGYI   V   +   +E    + G++ S K ++I    + +  +T +D+  +KF +
Sbjct: 123 L-IDDGYIQAVVVNAQEHLIEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDITDLKFGV 181

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQ +D I  SFV    D+  ++  LE     ++ +I+KIE    V+NF EI KASDGIMI
Sbjct: 182 EQELDLIAASFVRCNEDIDSMRKVLENFGRPNMPIIAKIENHLGVQNFQEIAKASDGIMI 241

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLG+E+ I  +P LQK + R +   G+  ITATQML SM    +PTRAEV+DVANAI
Sbjct: 242 ARGDLGIELSIVEVPALQKFMARVSRETGRFCITATQMLESMIRNPLPTRAEVSDVANAI 301

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
            DGT AVMLS ETA G +PI+AVK M  I + TE+  +     +L +           EA
Sbjct: 302 HDGTSAVMLSGETASGTYPIEAVKTMRSIIQETEKSFDYQAFFQLNDKNSALKVSPYLEA 361

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
           I  S I      + K I+  T+TG +   +S+++P   I   + N  V   L   +GVY 
Sbjct: 362 IGASGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYP 421

Query: 428 FCLEE 432
               E
Sbjct: 422 MLTSE 426


>pir||JC2456 pyruvate kinase (EC 2.7.1.40) - Trypanoplasma borelli
           >gi|673500|emb|CAA54473.1| (X77255) pyruvate kinase
           [Trypanoplasma borreli]
           Length = 497
           
 Score =  265 bits (671), Expect = 6e-70
 Identities = 158/417 (37%), Positives = 246/417 (58%), Gaps = 10/417 (2%)

Query: 12  KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
           KI+ TIGP++ S  ++K L++ G++V R+NFSHG++E H K I+ VR  + +L   V I 
Sbjct: 25  KIICTIGPSSQSVEVLKDLMKAGLNVARMNFSHGTYEYHQKTIDNVRKAASELGIHVGIA 84

Query: 72  ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIP---VEYKDFPRLVSKGDVI 128
            D  G +IR G    G V ++  + V+LTT +   ++ T     V+Y +  ++V  G  I
Sbjct: 85  LDTKGPEIRTGLFPAGDVVIEAHKTVILTTDETFKEKGTAEKFYVDYMNITKVVPVGGHI 144

Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
           ++ DG + L V ++ G+D+E V  +   + +RKGIN+P A + + AV+ +D+  ++F  +
Sbjct: 145 FVDDGLLDLIVVKISGKDIECVAQNTHTISNRKGINLPNADVDLPAVSEKDLMDLQFGAK 204

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
             VD +  SF+ +   V +V+          + VI+KIE    + N D I+ A+DGIM+A
Sbjct: 205 NRVDFVFASFIRNADQVNEVRQAF----GGKIAVIAKIENYQGIDNIDAIIDAADGIMVA 260

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLGVE+P E++ I QK ++ K N  GK VI ATQML SMT    PTRAEV+DVA ++L
Sbjct: 261 RGDLGVEIPAEKVVIAQKMIMSKCNKVGKTVICATQMLDSMTHGPRPTRAEVSDVAKSVL 320

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI-KEA 367
           DG D VMLS ETA GK+P++ V  M++I   T+     + M+    +    +   I +EA
Sbjct: 321 DGADCVMLSGETAKGKYPVETVVYMSRICCETQV--TMWNMAAFEAIKNLQSFPLIPEEA 378

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
           I  S ++++  L+ K IL  T TGR+A ++S+++P   I   S    VC  L  + G
Sbjct: 379 ICSSAVNSIFELHAKAILVLTNTGRSAHMVSKYRPPVPIICASQELDVCRLLSITRG 435


>gb|AAF55980.2| (AE003738) CG7069 gene product [Drosophila melanogaster]
           Length = 744
           
 Score =  265 bits (669), Expect = 1e-69
 Identities = 168/438 (38%), Positives = 248/438 (56%), Gaps = 24/438 (5%)

Query: 37  VVRLNFSHGSFEEHAKVIEKVRDI------SQKLDRRVAILADLPGLKIRVGEIKGGY-- 88
           VVR+NFSHGS E H + I+  R           L R +AI  D  G +IR G++ GG   
Sbjct: 3   VVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDR 62

Query: 89  --VELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDVIYLSDGYIVLRVEEVR 143
             +ELK G+KV L+T+  + D++    I V+Y+  P+LV  G+ +++ DG I L V+E +
Sbjct: 63  AEIELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESK 122

Query: 144 GQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVY 203
           G +V   V +GGKL S KGIN+P   + + +VT +D + +KF  EQ VD I  SF+    
Sbjct: 123 GDEVICQVENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDAN 182

Query: 204 DVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPI 263
            + +++  L    A  + +ISKIE    + N D+I++ SDGIM+ARGD+G+E+P E +P+
Sbjct: 183 ALKEIRQVLGPAGA-CIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPL 241

Query: 264 LQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIG 323
            QK ++ K N  GKPVI ATQM+ SMT +  PTRAE +DVANAI DG DAVMLS ETA G
Sbjct: 242 AQKSIVAKCNKVGKPVICATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKG 301

Query: 324 KFPIDAVKMMAKIAKVTEE--YRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNI 381
           K+P++ V+ MA+I    E   + ES   S  RE+           A+  +I +A      
Sbjct: 302 KYPVECVQCMARICAKVEAVLWYESLQNSLKREIRTSAADHI--SAVTTAIAEAATVGQA 359

Query: 382 KYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEE----GFDER 437
           + I+  +     A+++S  +P   I   + NE      +   G+Y   +EE     F+ R
Sbjct: 360 RAIVVASPCSMVAQMVSHMRPPCPIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSFNFR 419

Query: 438 DIIRLIKGLGLVESDDIV 455
            I++   GL L+   DI+
Sbjct: 420 RIMQ--SGLKLMGKMDIL 435


>gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus]
           Length = 500
           
 Score =  263 bits (666), Expect = 2e-69
 Identities = 172/501 (34%), Positives = 274/501 (54%), Gaps = 44/501 (8%)

Query: 10  KTKIVATIGPAT---------------------SSRNMIKKLIENGVSVVRLNFSHGSFE 48
           + KIVAT+GPA                      +S   I +LIE G +V R NFSHG+  
Sbjct: 4   RVKIVATLGPAVEIRGGKKFGEDGYWSEKLDPDASAKNIAQLIEEGANVFRFNFSHGNHA 63

Query: 49  EHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVEL--KRGEKVVL------- 99
           E  + ++ VR       ++V  L D  G +IR    +G   E   K GE++ +       
Sbjct: 64  EQGERMDVVRMAESIAGQKVGFLLDTKGPEIRTELFEGDAKEYAYKTGEQIRIATKQGLK 123

Query: 100 TTRDVVGDETTIPVEYKDFPRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVV--SGGKL 157
           +TRDV+       ++  D    V  G  + + DG + LRV +   +  E +V   + G +
Sbjct: 124 STRDVIALNVAGALDIFDD---VEVGKQVLVDDGKLGLRVVDKDAEKREFIVEVENDGII 180

Query: 158 FSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDA 217
             +KG+NIP   +P  A+  RD   I+F +EQG++ I +SFV +  DV +V++  E+   
Sbjct: 181 AKQKGVNIPYTKIPFPALAERDNADIRFGLEQGINFIAISFVRTAKDVQEVRAICEETGN 240

Query: 218 EDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGK 277
             V +++KIE    + N DEI++A+DGIMIARGD+G+E+P E +P+ QK +I K N  GK
Sbjct: 241 GHVKLLAKIENQQGIDNIDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGK 300

Query: 278 PVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIA 337
            V+TAT ML +MT +   TR+EV+DV NA++DGTDA MLS E+A G +P+++V+ MA I 
Sbjct: 301 IVVTATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGPYPVESVRTMATIH 360

Query: 338 KVTEEYRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLI 397
           K  +   + +G  RL     D +  T  E +A ++ DA  +++I+ I+  T +G TA LI
Sbjct: 361 KNAQTLLKEYG--RLNSSTFDRSSNT--EVVASAVKDATNSMHIQLIVALTESGNTASLI 416

Query: 398 SRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIKGL----GLVESDD 453
             ++P+  I+  + +E    +LM ++GV     E      D+  + + +    GLVES D
Sbjct: 417 DTYRPEADIWAITFDELTQKSLMLNWGVIPVVTETPSSTDDMFEVAERVALESGLVESGD 476

Query: 454 IVLMTEGKPIEKTMGTNSIKI 474
            +++  G P+  +  TN+++I
Sbjct: 477 NIVIVAGVPV-GSGNTNTMRI 496


>pir||JC1267 pyruvate kinase (EC 2.7.1.40) - yeast (Yarrowia lipolytica)
           Length = 527
           
 Score =  262 bits (663), Expect = 5e-69
 Identities = 167/449 (37%), Positives = 251/449 (55%), Gaps = 27/449 (6%)

Query: 34  GVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRVAILADLPGLKIRVGEIKGGYV-EL 91
           G+++VR+NFSHGS+E H  VIE  R+  Q+   R +AI  D  G +IR G  K     ++
Sbjct: 40  GLNIVRMNFSHGSYEYHQSVIENARESEQRFRGRPLAIALDTKGPEIRTGVTKDDKDWDV 99

Query: 92  KRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSK---GDVIYLSDGYIVLRV-EEVRGQDV 147
           K G  ++ +T     D+    + Y D+  +V +   G +I++ DG +  +V E++ G+ +
Sbjct: 100 KAGHVMLFSTNPKYKDQCDDKIMYIDYTNIVKQIDIGKIIFVDDGVLSFKVLEKIDGETL 159

Query: 148 EAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLK 207
           +   ++ GK+ SRKG+N+P   + + A++ +D   +KF +E GVD I  SFV +  DV  
Sbjct: 160 KVETLNNGKISSRKGVNLPGTDVDLPALSEKDKADLKFGVEHGVDMIFASFVRTANDVQA 219

Query: 208 VKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKE 267
           ++  L +   + + VISKIE    V NFDEILK +DG+M+ARGDLG+E+P  ++ I QK+
Sbjct: 220 IRDVLGEK-GKGIQVISKIENQQGVNNFDEILKETDGVMVARGDLGIEIPAPQVFIAQKQ 278

Query: 268 LIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPI 327
           LI K N  GKPVI ATQML SMT    PTRAEV+DV NA+LDG D VMLS ETA G +PI
Sbjct: 279 LIAKCNLAGKPVICATQMLDSMTYNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGTYPI 338

Query: 328 DAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYI 384
           ++VKMM +   V E+   Y   F  + +R L    T     E IA S + A      + I
Sbjct: 339 ESVKMMHETCLVAEKAIAYAPLF--NEMRTLTVRPTETV--ETIAISAVSASFEQQARAI 394

Query: 385 LTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFD------ERD 438
           +  + +G +ARL S+++P   I   + N +         GVY F   +         + D
Sbjct: 395 IVLSTSGTSARLCSKYRPNCPILMVTRNAQAARFSHLYRGVYPFIYHKARASNPAEWQHD 454

Query: 439 IIRLIK-------GLGLVESDDIVLMTEG 460
           +   +K        LG++   D+V+  +G
Sbjct: 455 VEERLKWGMDEAVALGILNKGDVVVAIQG 483


>dbj|BAB01059.1| (AB023041) pyruvate kinase [Arabidopsis thaliana]
           Length = 497
           
 Score =  262 bits (663), Expect = 5e-69
 Identities = 156/405 (38%), Positives = 239/405 (58%), Gaps = 21/405 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  MI+KL++ G++V R NFSHGS   H + ++ +R          A
Sbjct: 17  KTKIVCTLGPASRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGILCA 76

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D     IR G +K G  ++LK+G+++ ++    + GD  TI + YK     +  GDV
Sbjct: 77  VMLDTKSPVIRTGFLKEGKPIQLKQGQEITISIDYKIQGDSNTISMSYKKLAEDLKPGDV 136

Query: 128 IYLSDGYIVLRV---EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
           I  SDG I L V   ++  G  V     +   L  RK +N+P   + +  +T +D E I+
Sbjct: 137 ILCSDGTISLNVLSCDKYLGL-VRCRCENSALLGERKNVNLPGIVVDLPTLTEKDKEDIM 195

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           ++ +   +D I LSFV    D+++V+  L ++ ++ + ++SK+E  + V NFD+IL+ SD
Sbjct: 196 QWGVPNKIDIIALSFVRKGSDLIQVRKLLGEH-SKSIMLMSKVENQEGVMNFDKILENSD 254

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
             M+ARGDLG+E+PIE++ + QK +I KAN  GKPV+TATQML SMT    PTRAE TDV
Sbjct: 255 AFMVARGDLGMEIPIEKMFLAQKTMINKANAHGKPVVTATQMLESMTVSPRPTRAEATDV 314

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
           ANA+LDGTD VMLS ETA G  P  AV  M++I K  E++ +        +++   T G 
Sbjct: 315 ANAVLDGTDCVMLSGETAAGAHPETAVLTMSRICKEAEDFID-------YDILHKKTLGM 367

Query: 364 IK------EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
           +       E++A S +    ++    I+  TR G TA L+++++P
Sbjct: 368 VSLPLSPIESLAASAVSTARSVFASAIVVLTRGGYTAELVAKYRP 412


>emb|CAA24631.1| (V01321) pyruvate kinase [Saccharomyces cerevisiae]
           Length = 499
           
 Score =  262 bits (662), Expect = 7e-69
 Identities = 162/433 (37%), Positives = 251/433 (57%), Gaps = 17/433 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL--DRR 67
           +T I+ TIGP T++   +  L + G+++VR+NFSHGS+E H  VI+  R  S++L   R 
Sbjct: 20  RTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARK-SEELYPGRP 78

Query: 68  VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVG---DETTIPVEYKDFPRLVS 123
           +AI  D  G +IR G         +    +++ TT D      D+  + V+YK+  +++S
Sbjct: 79  LAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVIS 138

Query: 124 KGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI 182
            G +IY+ DG +  +V E V  + ++   ++ GK+ S KG+N+P   + + A++ +D E 
Sbjct: 139 AGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKED 198

Query: 183 IKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
           ++F ++ GV  +  SF+ +  DVL ++  L +   +DV +I KIE    V NFDEILK +
Sbjct: 199 LRFGVKNGVHMVFASFIRTANDVLTIREVLGEQ-GKDVKIIVKIENQQGVNNFDEILKVT 257

Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
           DG+M+ARGDLG+E+P   +  +QK+LI K+N  GKPVI ATQML SMT    PTRAEV+D
Sbjct: 258 DGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSD 317

Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDG 359
           V NAILDG D VMLS ETA G +PI+AV  MA+ A + E+   Y  ++    +R      
Sbjct: 318 VGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNY--DDMRNCTPKP 375

Query: 360 TRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
           T  T + ++ R  + A+     K I+  + +G T RL+S+++P   I   +   R     
Sbjct: 376 T-STTETSLPR--VAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFS 432

Query: 420 MFSYGVYAFCLEE 432
               GV+ F  E+
Sbjct: 433 HLYRGVFPFVFEK 445


>pir||E83104 pyruvate kinase II PA4329 [imported] - Pseudomonas aeruginosa
           (strain PAO1) >gi|9950554|gb|AAG07717.1|AE004849_4
           (AE004849) pyruvate kinase II [Pseudomonas aeruginosa]
           Length = 483
           
 Score =  261 bits (661), Expect = 9e-69
 Identities = 173/481 (35%), Positives = 268/481 (54%), Gaps = 20/481 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKIVAT+GPA++S  ++++LI  G+ V RLNFSHG+ +EH      VR+++ K  R VA
Sbjct: 5   RTKIVATLGPASNSPEVLEQLILAGIDVARLNFSHGTPDEHRARARLVRELAAKHGRFVA 64

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDV--VGDETTIPVEYKDFPRLVSKGDV 127
           +L DL G KIR+ +     +EL+ G+K   +T      G +  + ++Y D  +    GD 
Sbjct: 65  LLGDLQGPKIRIAKFANKRIELQVGDKFRFSTSHARDAGTQEVVGIDYPDLVKDCGVGDE 124

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + L DG +V+ VEEV   ++   V+ GG L   KGIN     L   A+T +D   IK A 
Sbjct: 125 LLLDDGRVVMVVEEVAADELRCRVLIGGPLSDHKGINRRGGGLTAPALTDKDKADIKLAA 184

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
           +  +D + +SF     D+   +  L +   +  ++++KIER +AV +    D +++ASD 
Sbjct: 185 DMDLDYVAVSFPRDAKDMEYARRLLTEAGGK-AWLVAKIERAEAVADDDALDGLIRASDA 243

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
           +M+ARGDLGVE+    L  +QK++I  A    K VITATQM+ SM    +PTRAEV+DVA
Sbjct: 244 VMVARGDLGVEIGDAELVGIQKKIILHARRNNKVVITATQMMESMIHSPMPTRAEVSDVA 303

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMS-RLRELVEDGTRGT 363
           NA+LD TDAVMLS E+A G++P++AVK MA++ +  E++  S   S RL +     T   
Sbjct: 304 NAVLDYTDAVMLSAESAAGEYPVEAVKAMARVCQGAEKHPTSQKSSHRLGQ-----TFDR 358

Query: 364 IKEAIA-RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
             E+IA  S+  A     IK I+  T +G T  ++SR +    I+ +S +      +   
Sbjct: 359 CDESIALASMYTANHFPGIKAIICLTESGFTPLIMSRIRSSVPIYAYSPHRETQARVAMF 418

Query: 423 YGVYAFCLE------EGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQ 476
            GV     +      E   +  +  L+K  G+V   D V++T+G       GTN++K+  
Sbjct: 419 RGVETIPFDPAALPAEKVSQAAVDELLK-RGVVTKGDWVILTKGDSYTAQGGTNTMKVLH 477

Query: 477 I 477
           +
Sbjct: 478 V 478


>dbj|BAA88185.1| (AP000836) ESTs AU081247(C50004),AU068940(C51113) correspond to a
           region of the predicted gene.~Similar to pyruvate kinase
           (Q42954) [Oryza sativa]
           Length = 507
           
 Score =  260 bits (658), Expect = 2e-68
 Identities = 157/398 (39%), Positives = 231/398 (57%), Gaps = 7/398 (1%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  MI +L+  G+ V R NFSHGS E H + ++ +R   +      A
Sbjct: 17  KTKIVCTLGPASRSVEMIGRLLRAGMCVARFNFSHGSHEYHQETLDNLRAAMESTGILCA 76

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  V+LK+G+++ ++T   + GD+  I + YK     +  G V
Sbjct: 77  VMLDTKGPEIRTGFLKDGKPVQLKKGQEITVSTDYSIKGDDNMISMSYKKLAVDLKPGSV 136

Query: 128 IYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-IIK 184
           I  +DG I L V     +   V     +   L  RK +N+P   + +  +T +D E I+K
Sbjct: 137 ILCADGTITLTVLHCDKEQGLVRCRCENTAMLGERKNVNLPGVIVDLPTLTEKDKEDILK 196

Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
           + +   +D I LSFV    D+++V+  L K+ A+ + ++SK+E  + V NFD+IL  SD 
Sbjct: 197 WGVPNKIDMIALSFVRKGSDLVEVRKVLGKH-AKSIMLMSKVENQEGVANFDDILAQSDA 255

Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
            M+ARGDLG+E+PIE++   QK +I K N +GKPV+TATQML SM     PTRAE TDVA
Sbjct: 256 FMVARGDLGMEIPIEKIFYAQKVMIFKCNIQGKPVVTATQMLESMIKSPRPTRAEATDVA 315

Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
           NA+LDGTD VMLS ETA G +P  AV+ MAKI    E   +   + +            +
Sbjct: 316 NAVLDGTDCVMLSGETAAGAYPELAVRTMAKICLQAESCVDHAAVFKSITASAPIPMSPL 375

Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
            E++A S +    +     IL  TR G TARL+++++P
Sbjct: 376 -ESLASSAVRTANSAKAALILVLTRGGTTARLVAKYRP 412


>sp|P94685|KPYK_CHLTR PYRUVATE KINASE (PK) >gi|7434455|pir||G71527 probable pyruvate
           kinase - Chlamydia trachomatis (serotype D, strain
           UW3/Cx) >gi|3328751|gb|AAC67927.1| (AE001306) Pyruvate
           Kinase [Chlamydia trachomatis]
           Length = 485
           
 Score =  259 bits (656), Expect = 4e-68
 Identities = 154/419 (36%), Positives = 245/419 (57%), Gaps = 4/419 (0%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKI+ TIGPAT++  M++KL++ G++V RLNFSHG+ E H + I  ++++ +K    +A
Sbjct: 4   RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLA 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKD--FPRLVSKGDV 127
           I+ D  G +IR+G+++   ++++ G+++ L +++++G + +    Y    FP +  +  V
Sbjct: 64  IMLDTKGPEIRLGQVESP-IKVQPGDRLTLVSKEILGSKESGVTLYPSCVFPYVRERAPV 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DGYI   V   +   VE    + G++ S K ++I    + +  +T +D+  +KF +
Sbjct: 123 L-IDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDIADLKFGV 181

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQ +D I  SFV    D+  ++  LE     ++ +I+KIE    V+NF EI +A+DGIMI
Sbjct: 182 EQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGIMI 241

Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
           ARGDLG+E+ I  +P LQK + R +   G+  ITATQML SM    +PTRAEV+DVANAI
Sbjct: 242 ARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAI 301

Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
            DGT AVMLS ETA+G  P+ AVK M  I + TE+  +     +L +           EA
Sbjct: 302 YDGTSAVMLSGETALGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPYLEA 361

Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
           I  S I      + K I+  T+TG +   +S+++P   I   + N  V   L   +GVY
Sbjct: 362 IGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVY 420


>sp|Q42954|KPYC_TOBAC PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|542061|pir||S41379 pyruvate
           kinase (EC 2.7.1.40), cytosolic - common tobacco
           >gi|444023|emb|CAA82628.1| (Z29492) pyruvate kinase
           [Nicotiana tabacum]
           Length = 508
           
 Score =  258 bits (652), Expect = 1e-67
 Identities = 161/405 (39%), Positives = 240/405 (58%), Gaps = 21/405 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  MI+KL+  G++V R NFSHGS + H + I+ +R   +      A
Sbjct: 19  KTKIVCTLGPASRSVPMIEKLLRAGMNVARFNFSHGSHDYHQETIDNLRQAMESTGILCA 78

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K    V+LK+G+++ ++T   + GDE+ I + YK     V    V
Sbjct: 79  VMLDTKGPEIRTGFLKDAKPVQLKQGQEITISTDYSIKGDESMICMSYKKLAEDVKPQSV 138

Query: 128 IYLSDGYI---VLRVEEVRGQD---VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
           I  +DG I   VL  ++  G D    E   V G     RK +N+P   + +  +T +D +
Sbjct: 139 ILCADGQITFTVLSCDKENGLDRCRCENTAVLG----ERKNVNLPGVIVDLPTLTDKDKD 194

Query: 182 -IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
            I+ + +   +D I LSFV    D+++V+  L ++ A+++ ++SK+E  + V NFD+IL 
Sbjct: 195 DILNWGVPNHIDMIALSFVRKGSDLVEVRKLLGEH-AKNILLMSKVENQEGVANFDDILL 253

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
            SD  M+ARGDLG+E+PIE++ + QK +I K N +GKPV+TATQML SM     PTRAE 
Sbjct: 254 NSDAFMVARGDLGMEIPIEKIFLAQKVMIYKCNIQGKPVVTATQMLESMIKSPRPTRAEA 313

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVE 357
           TDVANA+LDGTD VMLS ETA G +P  AV  MAKI   A+ T +Y + F     R +  
Sbjct: 314 TDVANAVLDGTDCVMLSGETAAGAYPDLAVGTMAKICIEAESTIDYPDVF----KRIMSN 369

Query: 358 DGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
                +  E++A S +    +     IL  TR G TA+L+++++P
Sbjct: 370 APVPMSPLESLASSAVRTANSAKAALILVLTRGGSTAKLVAKYRP 414


>gi|6324923 pyruvate kinase; Pyk2p [Saccharomyces cerevisiae]
           >gi|1730063|sp|P52489|KPY2_YEAST PYRUVATE KINASE 2
           >gi|2117875|pir||S67256 probable pyruvate kinase (EC
           2.7.1.40) YOR347c - yeast  (Saccharomyces cerevisiae)
           >gi|1199849|emb|CAA65034.1| (X95720) O6342
           [Saccharomyces cerevisiae] >gi|1420756|emb|CAA99675.1|
           (Z75255) ORF YOR347c [Saccharomyces cerevisiae]
           Length = 506
           
 Score =  257 bits (650), Expect = 2e-67
 Identities = 163/468 (34%), Positives = 259/468 (54%), Gaps = 20/468 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEK-VRDISQKLDRRV 68
           +T I+ TIGP T+S   I  L + G++++RLNFSHGS+E H  VIE  V+   Q   R +
Sbjct: 22  RTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRPL 81

Query: 69  AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDV----VGDETTIPVEYKDFPRLVSK 124
           AI  D  G +IR G            +  ++ T D       ++  + ++Y +  +++  
Sbjct: 82  AIALDTKGPEIRTGRTLNDQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVP 141

Query: 125 GDVIYLSDGYIVLRVEEVRGQ-DVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           G  IY+ DG +  +V ++  + ++    V+ G + S KG+N+P   + +  ++ +DM+ +
Sbjct: 142 GRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDL 201

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           +F +  G+  +  SF+ +  DVL ++  L  ++ +D+ +ISKIE    + NFDEIL+ +D
Sbjct: 202 QFGVRNGIHIVFASFIRTSEDVLSIRKALG-SEGQDIKIISKIENQQGLDNFDEILEVTD 260

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+MIARGDLG+E+    +  +QK+LI K N  GKPVI ATQML SMT    PTRAEV+DV
Sbjct: 261 GVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDV 320

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
            NA+LDG D VMLS ETA G +P++AV +MA  A + E       +   LR+     T  
Sbjct: 321 GNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTST 380

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
           T  E +A +   A+   + K I+  + TG TARL+S+++P   I   + + R        
Sbjct: 381 T--ETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLY 438

Query: 423 YGVYAFCLE-EGFDE--RDIIRLIK-------GLGLVESDDIVLMTEG 460
            GV+ F  E +  D+   D+ R +K         G+V++ D V+  +G
Sbjct: 439 RGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQG 486


>sp|Q42806|KPYC_SOYBN PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|7434443|pir||T07787 pyruvate
           kinase (EC 2.7.1.40) - soybean >gi|466350|gb|AAA17000.1|
           (L08632) pyruvate kinase [Glycine max]
           Length = 511
           
 Score =  256 bits (647), Expect = 4e-67
 Identities = 155/401 (38%), Positives = 233/401 (57%), Gaps = 13/401 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GPA+ S  M +KL+  G++V R NFSHG+ + H + +  ++          A
Sbjct: 22  KTKIVCTLGPASRSVEMTEKLLRAGMNVARFNFSHGTHDYHQETLNNLKTAMHNTGILCA 81

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  ++LK G++V +TT  D+ GD   I + YK  P  +  G+ 
Sbjct: 82  VMLDTKGPEIRTGFLKDGKPIQLKEGQEVTITTDYDIKGDPEMISMSYKKLPVHLKPGNT 141

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVV-----SGGKLFSRKGINIPKAYLPVEAVTPRDME- 181
           I  SDG I L V      D +A  V     +   L  RK +N+P   + +  +T +D E 
Sbjct: 142 ILCSDGTITLTVLSC---DPDAGTVRCRCENTATLGERKNVNLPGVVVDLPTLTEKDKED 198

Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
           I+ + +   +D I LSFV    D++ V+  L  + A+++ ++SK+E  + V NFDEIL+ 
Sbjct: 199 ILGWGVPNKIDMIALSFVRKGSDLVNVRKVLGPH-AKNIQLMSKVENQEGVLNFDEILRE 257

Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
           +D  M+ARGDLG+E+P+E++ + QK +I K N  GKPV+TATQML SM     PTRAE T
Sbjct: 258 TDAFMVARGDLGMEIPVEKIFLAQKMMIYKCNLVGKPVVTATQMLESMIKSPRPTRAEAT 317

Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR 361
           DVANA+LDGTD VMLS E+A G +P  AVK+MA+I  +  E    +G      +      
Sbjct: 318 DVANAVLDGTDCVMLSGESAAGAYPELAVKIMARIC-IEAESSLDYGAIFKEMIRSTPLP 376

Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
            +  E++A S +        K I+  TR G TA+L+++++P
Sbjct: 377 MSPLESLASSAVRTANKAKAKLIVVLTRGGSTAKLVAKYRP 417


>dbj|BAA95686.1| (AB042618) pyruvate kinase [Hydrogenophilus thermoluteolus]
           Length = 473
           
 Score =  254 bits (643), Expect = 1e-66
 Identities = 170/472 (36%), Positives = 261/472 (55%), Gaps = 13/472 (2%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
           TKIVAT+GPA+S    +++L+  GV VVRLNFSHG+ +EH      VR ++Q+  R V I
Sbjct: 4   TKIVATLGPASSDPATLERLLLAGVDVVRLNFSHGTADEHRARASLVRALAQQTQRPVGI 63

Query: 71  LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYL 130
           L DL G KIR+G      V L +G++  L      GD T + ++Y +    V  GD++ L
Sbjct: 64  LGDLQGPKIRIGRFTTNAVTLSKGQRFRLDCDLAPGDATRVGLDYPELIDDVEVGDILLL 123

Query: 131 SDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI-IKFAIEQ 189
            DG I L++ E     +   V+ GG L + KGIN     L   A+T +D  + I  ++ +
Sbjct: 124 DDGKIRLQIVEKCADALITQVLVGGTLSNHKGINKLGGGLSAPALTAKDRAVPISRSLPK 183

Query: 190 GVD-AIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
                + +SFV    ++ + +  L +       +I+KIER +A+ N D IL+ASDG+M+A
Sbjct: 184 SASITVAVSFVKHAEEMHEARH-LARAAGSRARLIAKIERVEAIANLDAILEASDGVMVA 242

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDL VE+    +P LQK ++R+A    +  ITATQM+ SM    VPTRAEV+DVANA+L
Sbjct: 243 RGDLAVEVGDAAVPALQKRILRRAREMNRLSITATQMMESMVHSPVPTRAEVSDVANAVL 302

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           DGTDAVMLS ETA G++P++AV+ MA++    +   +    + L + +       + EAI
Sbjct: 303 DGTDAVMLSAETAAGQYPVEAVEAMARVCAEADASND----AHLDQELLGRRFHRVDEAI 358

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV--Y 426
           A S + +   L +K I+  T++G TA  +SR      I+  + +     +L     V   
Sbjct: 359 AVSAVWSGYHLGVKAIVALTQSGATALWMSRIASILPIYALTPDPVTFGHLTLFRQVTPV 418

Query: 427 AFCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEKTMGTNSIKI 474
            F L    D   ++  I+ L    G     + + +T G+P+ +  G+N++KI
Sbjct: 419 RFDLNPASDPAMLLTQIRTLLVSNGWAAPGETIAVTFGEPMGQPGGSNTLKI 470


>pir||T47704 pyruvate kinase-like protein - Arabidopsis thaliana
           >gi|7263553|emb|CAB81590.1| (AL161667) pyruvate
           kinase-like protein [Arabidopsis thaliana]
           Length = 510
           
 Score =  252 bits (638), Expect = 5e-66
 Identities = 151/405 (37%), Positives = 239/405 (58%), Gaps = 21/405 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKI+ T+GP + S  MI+KL++ G++V R NFSHGS   H + ++ +R          A
Sbjct: 17  KTKIICTLGPVSRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGILSA 76

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  ++L +G+++ ++   ++ GD   I + YK     V  GDV
Sbjct: 77  VMLDTKGPEIRTGFLKEGKPIQLNQGQEITISIDYMIEGDSNVISMSYKKLAEDVKPGDV 136

Query: 128 IYLSDGYI---VLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
           I  SDG I   VL  ++  G  V     +   L  RK +N+P   + +  +T +D E II
Sbjct: 137 ILCSDGTISLTVLSCDKSFGL-VRCRCENSAILGERKNVNLPGIVVDLPTLTEKDKEDII 195

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           ++ +   +D I LSFV    D+ +V+  L ++ ++++ ++SK+E  + V N ++IL+ SD
Sbjct: 196 QWGVPNKIDIIALSFVRKGSDLTEVRRLLGEH-SKNIMLMSKVENQEGVMNCEKILENSD 254

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
             M+ARGDLG+E+PIE++ + QK +I+ AN  GKPV+TATQML SMT    PTRAE TDV
Sbjct: 255 AFMVARGDLGMEIPIEKMFLAQKTMIKMANALGKPVVTATQMLESMTVSPRPTRAEATDV 314

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
           ANA+LDGTD VMLS ETA G  P  AV  M++I K  E++ +        +++   T G 
Sbjct: 315 ANAVLDGTDCVMLSGETAAGAHPEAAVLTMSRICKEAEDFID-------YDILHKKTLGM 367

Query: 364 IK------EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
           +       E++A S++    ++    I+  T+ G TA L+++++P
Sbjct: 368 VSLPLSPIESLAASVVSTAQSVFASAIVVLTKGGYTAELVAKYRP 412


>pir||A82427 pyruvate kinase II VCA0708 [imported] - Vibrio cholerae  (group O1
           strain N16961) >gi|9658127|gb|AAF96607.1| (AE004400)
           pyruvate kinase II [Vibrio cholerae]
           Length = 486
           
 Score =  252 bits (638), Expect = 5e-66
 Identities = 167/480 (34%), Positives = 259/480 (53%), Gaps = 14/480 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIVAT+GPA+ +R  + +LI+ GV+VVRLNFSHGS EEH    E VR+I+Q+L+  V 
Sbjct: 3   KTKIVATLGPASQTRETLTQLIQAGVNVVRLNFSHGSAEEHIARAEMVREIAQQLNVSVG 62

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDV 127
           +L DL G KIR+     G ++L  G+  +L        G +  + ++Y +    ++ G++
Sbjct: 63  VLVDLQGPKIRIACFAEGAIQLSAGDTFILDGHLDGQAGTQERVGLDYPELIDDLNVGNI 122

Query: 128 IYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
           + L DG I L V  V  Q   V  + ++ GKL +RKGIN+    L   A+T +D   I  
Sbjct: 123 LLLDDGRIQLEVTAVDMQARLVHTIALNSGKLSNRKGINLLGGGLSAPALTEKDKLDIIT 182

Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKAS 242
           A E   D + +SF  +  D+   +    +       +++K+ER + V +    D +++AS
Sbjct: 183 AAELQADFLAVSFPRNAEDIEYARQLATQAGCH-AHIVAKVERAEVVASEEAMDSVIRAS 241

Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
           D IM+ARGDLGVE+   RLP +QK LI +A   GKPVITATQM+ SM    +PTRAEV D
Sbjct: 242 DVIMVARGDLGVEIGDARLPSVQKALIARAKHLGKPVITATQMMESMIENPLPTRAEVLD 301

Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
           VANA++DGTDA+MLS E+A G++P++ V+ M +IA+  E   E+       + ++     
Sbjct: 302 VANAVIDGTDAIMLSAESAAGRYPVETVQAMVRIAQGVE--HETHCAQNCWDALQHLCSD 359

Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
             K     S+I A        +   T  G T  L+SR + +  I+  S    +   L   
Sbjct: 360 AGKSFALSSMISASKVNKDLGVAIVTEQGETPLLMSRCQSQATIWAVSDKPALLRKLAIL 419

Query: 423 YGV----YAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
            GV    +    ++G     +I L++     +    +L+T+ + +E     N  ++  +A
Sbjct: 420 RGVTPTYFPHLDKQGDIATQLIHLLRKPAQEKKIASILVTQLESVEGVGHVNVCRLLNLA 479


>gb|AAB41226.1| (U83196) pyruvate kinase [Chlamydia trachomatis]
           Length = 496
           
 Score =  251 bits (634), Expect = 1e-65
 Identities = 152/421 (36%), Positives = 242/421 (57%), Gaps = 8/421 (1%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKI+ TIGPAT++  M++KL++ G++V RLNFSHG+ E H + I  ++++ +K    +A
Sbjct: 15  RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLA 74

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT----IPVEYKDFPRLVSKG 125
           I+ D  G +IR+G+++   ++++ G+++ L +++++G + +    I V Y  + R   + 
Sbjct: 75  IMLDTKGPEIRLGQVESP-IKVQPGDRLTLVSKEILGSKESALLFIQVVYSPYVR---ER 130

Query: 126 DVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
             + + DGYI   V   +   VE    + G++ S K ++I    + +  +T +D+  +KF
Sbjct: 131 APVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDIADLKF 190

Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGI 245
            +EQ +D I  SFV    D+  ++  LE     ++ +I+KIE    V+NF EI +A+DGI
Sbjct: 191 GVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGI 250

Query: 246 MIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVAN 305
           MIARGDLG+E+ I  +P LQK + R +   G+  ITATQML SM    +PTRAEV+DVAN
Sbjct: 251 MIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVAN 310

Query: 306 AILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIK 365
           AI DGT AVMLS ETA G  P+ AVK M  I + TE+  +     +L +           
Sbjct: 311 AIYDGTSAVMLSGETASGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPYL 370

Query: 366 EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV 425
           EA     I      + K I+  T+TG +   +S+++P   I   + N  V   L   +GV
Sbjct: 371 EANWVFWIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGV 430

Query: 426 Y 426
           Y
Sbjct: 431 Y 431


>sp|Q07637|KPYK_LACLA PYRUVATE KINASE >gi|421428|pir||B40620 pyruvate kinase (EC
           2.7.1.40) - Lactococcus lactis subsp. lactis (strain
           LM0230) >gi|308858|gb|AAA99895.1| (L07920) ATP:pyruvate
           2-O-phosphotransferase [Lactococcus lactis]
           Length = 502
           
 Score =  247 bits (624), Expect = 2e-64
 Identities = 165/500 (33%), Positives = 261/500 (52%), Gaps = 40/500 (8%)

Query: 10  KTKIVATIGPAT---------------------SSRNMIKKLIENGVSVVRLNFSHGSFE 48
           + KIV+T+GPA                      +S   I  LIE G +V R NFSHG   
Sbjct: 4   RVKIVSTLGPAVEIRGGKKFGESGYWGESLDVEASAKNIAALIEEGANVFRFNFSHGDHP 63

Query: 49  EHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGY--VELKRGEKV-VLTTRDVV 105
           E    +  V    +    +V  L D  G ++R      G   + +  G+K  V T + + 
Sbjct: 64  EQGARMATVHRAEEIAGHKVGFLLDTKGPEMRTELFTDGADSISVVTGDKFRVATKQGLK 123

Query: 106 GDETTIPVEYK---DFPRLVSKGDVIYLSDGYIVLRV--EEVRGQDVEAVVVSGGKLFSR 160
                I +      D    V  G  I + DG + L +  ++   ++ E    + G +  +
Sbjct: 124 STPELIALNVAGGLDIFDDVEIGQTILIDDGKLGLSLTGKDAATREFEVEAQNDGVIGKQ 183

Query: 161 KGINIPKAYLPVEAVTPRDMEIIKFAIEQ--GVDAIGLSFVGSVYDVLKVKSFLEKNDAE 218
           KG+NIP   +P  A+  RD   I+F + Q  G++ I +SFV +  DV +V+   E+    
Sbjct: 184 KGVNIPNTKIPFPALAERDDADIRFGLSQPGGINFIAISFVRTANDVKEVRRICEETGNP 243

Query: 219 DVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKP 278
            V +++KIE    + N DEI++A+DGIMIARGD+G+E+P E +P+ QK +I K N  GK 
Sbjct: 244 HVQLLAKIENQQGIENLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKLIISKVNKAGKI 303

Query: 279 VITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAK 338
           V+TAT ML SMT     TR+E++DV NA++DGTDA MLS E+A GK+P ++V+ MA + K
Sbjct: 304 VVTATNMLESMTYNPRATRSEISDVFNAVIDGTDATMLSGESANGKYPRESVRTMATVNK 363

Query: 339 VTEEYRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLIS 398
             +   + +G    R   E   + T+ E +A S+ +A   +++K I+  T +G TARLIS
Sbjct: 364 NAQTMLKEYG----RLHPERYDKSTVTEVVAASVKNAAEAMDVKLIVALTESGNTARLIS 419

Query: 399 RFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIKGL----GLVESDDI 454
           + +P   I   + +E+V   LM ++GV     E+     D+  + + +    GLVE+ D 
Sbjct: 420 KHRPDADILAITFDEKVERGLMINWGVIPMMTEKPASTDDMFEVAEKVALASGLVEAGDN 479

Query: 455 VLMTEGKPIEKTMGTNSIKI 474
           +++  G P+  T  TN+++I
Sbjct: 480 IIIVAGVPV-GTGRTNTMRI 498


>gb|AAF44707.1| (AF242871) cytosolic pyruvate kinase [Lilium longiflorum]
           Length = 510
           
 Score =  244 bits (616), Expect = 2e-63
 Identities = 151/402 (37%), Positives = 234/402 (57%), Gaps = 15/402 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTK+V T+GP++ S  M++KL+  G++  R NFSHG+ E H + ++ +R   Q      A
Sbjct: 21  KTKLVCTLGPSSRSVPMLEKLLRAGMNTARFNFSHGTHEYHQETLDNLRIAMQNTQILCA 80

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  V+ K G++++++T  D+ G   TI + YK  P  +  G  
Sbjct: 81  VVLDTKGPEIRTGFLKDGKAVQPKEGQEIIVSTDYDLKGGGNTITMSYKKLPVDMKPGGT 140

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVV-----SGGKLFSRKGINIPKAYLPVEAVTPRDME- 181
           I  +DG I L V      D +A  V     +   L  RK +N+P   + +  +T +D E 
Sbjct: 141 ILCADGSISLTVLSC---DPDAGTVRCRCENTALLGERKNVNLPGVVVDLPTLTEKDKED 197

Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
           I+++ +   +D I LSFV    D++ V+  L  + A+++ ++SK+E  + V NFDEILK 
Sbjct: 198 ILEWGVPNNIDMIALSFVRKGSDLVNVRQVLGSH-AKNIKLMSKVENQEGVVNFDEILKE 256

Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
           +D  M+ARGDLG+E+P+E++ + QK +I   N  GKPV+TATQML SM     PTRAE T
Sbjct: 257 TDAFMVARGDLGMEIPVEKIFLAQKLMIYICNLAGKPVVTATQMLESMIKSPRPTRAEAT 316

Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR 361
           DVANA+LDGTD VMLS E+A G +   AVK+MAKI    E   +   +   +E++     
Sbjct: 317 DVANAVLDGTDCVMLSGESAAGAYLEIAVKVMAKICIEAESSLDYDAI--FKEMIRSAPL 374

Query: 362 G-TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
             +  E++A S +          I+  TR G TA+L+++++P
Sbjct: 375 PMSPLESLASSAVRTANKAKAALIVVLTRGGTTAKLVAKYRP 416


>sp|P22200|KPYC_SOLTU PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|100463|pir||S12248 pyruvate
           kinase (EC 2.7.1.40) - potato >gi|22576|emb|CAA37727.1|
           (X53688) pyruvate kinase [Solanum tuberosum]
           Length = 510
           
 Score =  243 bits (615), Expect = 2e-63
 Identities = 147/404 (36%), Positives = 237/404 (58%), Gaps = 11/404 (2%)

Query: 5   RLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL 64
           R+P  KTKIV T+GP++ +  M++KL+  G++V R NFSHG+ E H + ++ ++   Q  
Sbjct: 18  RIP--KTKIVCTLGPSSRTVPMLEKLLRAGMNVARFNFSHGTHEYHQETLDNLKIAMQNT 75

Query: 65  DRRVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLV 122
               A++ D  G +IR G +  G  ++LK G+++ ++T   + G+E  I + YK     +
Sbjct: 76  QILCAVMLDTKGPEIRTGFLTDGKPIQLKEGQEITVSTDYTIKGNEEMISMSYKKLVMDL 135

Query: 123 SKGDVIYLSDGYIVLRVE--EVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
             G+ I  +DG I L V   +     V     +   L  RK +N+P   + +  +T +D 
Sbjct: 136 KPGNTILCADGTITLTVLSCDPPSGTVRCRCENTATLGERKNVNLPGVVVDLPTLTEKDK 195

Query: 181 E-IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEIL 239
           E I+++ +   +D I LSFV    D++ V+  L  + A+ + ++SK+E  + V NFDEIL
Sbjct: 196 EDILEWGVPNNIDMIALSFVRKGSDLVNVRKVLGPH-AKRIQLMSKVENQEGVINFDEIL 254

Query: 240 KASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAE 299
           + +D  M+ARGDLG+E+P+E++ + QK +I K N  GK V+TATQML SM     PTRAE
Sbjct: 255 RETDSFMVARGDLGMEIPVEKIFLAQKMMIYKCNLAGKAVVTATQMLESMIKSPAPTRAE 314

Query: 300 VTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVE-D 358
            TDVANA+LDGTD VMLS E+A G +P  AVK+M++I    E   ++  +   +E++   
Sbjct: 315 ATDVANAVLDGTDCVMLSGESAAGAYPELAVKIMSRICIEAESSLDNEAI--FKEMIRCT 372

Query: 359 GTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
               +  E++A S +        K I+  TR G TA+L+++++P
Sbjct: 373 PLPMSPLESLASSAVRTANKARAKLIVVLTRGGSTAKLVAKYRP 416


>pir||JC1481 pyruvate kinase (EC 2.7.1.40), cytosolic - potato
           Length = 510
           
 Score =  242 bits (611), Expect = 7e-63
 Identities = 147/404 (36%), Positives = 237/404 (58%), Gaps = 11/404 (2%)

Query: 5   RLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL 64
           R+P  KTKIV T+GP++ +  M++KL+  G++V R NFSHG+ E H + ++ ++   Q  
Sbjct: 18  RIP--KTKIVCTLGPSSRTVPMLEKLLRAGMNVARFNFSHGTHEYHQETLDNLKIAMQNT 75

Query: 65  DRRVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLV 122
               A++ D  G +IR G +  G  ++LK G+++ ++T   + G+E  I + YK     +
Sbjct: 76  QILCAVMLDTKGPEIRTGFLTDGKPIQLKEGQEITVSTDYTIKGNEEMISMSYKKLVVDL 135

Query: 123 SKGDVIYLSDGYIVLRVE--EVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
             G+ I  +DG I L V   +     V     +   L  RK +N+P   + +  +T +D 
Sbjct: 136 KPGNTILCADGTITLTVLSCDPPSGTVRCRCENSATLGERKNVNLPGVVVDLPTLTEKDK 195

Query: 181 E-IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEIL 239
           E I+++ +   +D I LSFV    D++ V+  L  + A+ + ++SK+E  + V NFDEIL
Sbjct: 196 EDILEWGVPNNIDMIALSFVRKGSDLVNVRKALGPH-AKRIQLMSKVENQEGVINFDEIL 254

Query: 240 KASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAE 299
           + +D  M+ARGDLG+E+P+E++ + QK +I K N  GK V+TATQML SM     PTRAE
Sbjct: 255 RETDSFMVARGDLGMEIPVEKIFLAQKMMIYKCNLAGKAVVTATQMLESMIKSPRPTRAE 314

Query: 300 VTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVE-D 358
            TDVANA+LDGTD VMLS E+A G +P  AVK+M++I    E   ++  +   +E++   
Sbjct: 315 ATDVANAVLDGTDCVMLSGESAAGAYPELAVKIMSRICIEAESSLDNEAI--FKEMIRCT 372

Query: 359 GTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
               +  E++A S +        K I+  TR G TA+L+++++P
Sbjct: 373 PLPMSPLESLASSAVRTANKARAKLIVVLTRGGSTAKLVAKYRP 416


>sp|P31865|KPYK_TRIRE PYRUVATE KINASE >gi|484468|pir||JN0780 pyruvate kinase (EC
           2.7.1.40) - fungus (Trichoderma reesei)
           >gi|170553|gb|AAA02922.1| (L07060) pyruvate kinase
           [Hypocrea jecorina]
           Length = 538
           
 Score =  241 bits (609), Expect = 1e-62
 Identities = 162/488 (33%), Positives = 258/488 (52%), Gaps = 29/488 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVR-DISQKLDRRV 68
           +T I+ TIGP T+S   + KL + G++V R+NFSHGS+E H  VI+ VR  ++    R V
Sbjct: 43  RTSIICTIGPKTNSVEALNKLRDAGLNVARMNFSHGSYEYHQSVIDNVRASVAAHPGRPV 102

Query: 69  AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVG---DETTIPVEYKDFPRLVSK 124
           AI  D  G +IR G   G   + +  G  +  TT +      D   + V+YK+  +++  
Sbjct: 103 AIALDTKGPEIRTGNTAGDVDIPISAGTVMNFTTDEKYATACDTQNMYVDYKNITKVIQP 162

Query: 125 GDVIYLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
           G VIY+ DG +   V  ++  Q VE    + G + SRKG+N+P   + + A++ +D   +
Sbjct: 163 GRVIYVDDGVLAFDVLSIKDDQTVEVRARNNGFISSRKGVNLPNTDVDLPALSEKDKADL 222

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           +F ++  VD +  SF+    D+  ++  L   + + + +I+KIE    + NF EIL+ +D
Sbjct: 223 RFGVKNNVDMVFASFIRRAQDIKDIRDVLGP-EGKQIQIIAKIENRQGLNNFAEILEETD 281

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
           G+M+ARGDLG+E+P   +   QK++I   N  GKPVI ATQML SM     PTRAE++DV
Sbjct: 282 GVMVARGDLGIEIPAAEVFAAQKKMIAMCNIAGKPVICATQMLESMIKNPRPTRAEISDV 341

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVEDGT 360
            NA+ DG D VMLS ETA G +P +++  M +    A+ T  Y   F    +  LV+   
Sbjct: 342 GNAVTDGADCVMLSGETAKGNYPAESIHEMHEASLKAENTIPYVSHF--EEMCTLVKRPV 399

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
             +  E+ A + + A   L    I+  + +G +ARL+S+++P   IF  + N        
Sbjct: 400 --STVESCAMAAVRASLDLGAGGIIVLSTSGDSARLLSKYRPVCPIFMVTRNPTTSRFSH 457

Query: 421 FSYGVYAFCLEE---GFD----ERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMG----- 468
              GVY F   E    FD    + D+ + IK   +  + ++  +T G  +    G     
Sbjct: 458 LYRGVYPFLYPEQKPDFDTVNWQEDVDKRIK-WAVTRAIELKTLTAGDTVVVVQGWKGGM 516

Query: 469 --TNSIKI 474
             TN+++I
Sbjct: 517 GNTNTLRI 524


>pir||A72119 pyruvate kinase CP0677 [imported] - Chlamydophila pneumoniae
           (strains CWL029 and AR39) >gi|4376358|gb|AAD18250.1|
           (AE001596) Pyruvate Kinase [Chlamydophila pneumoniae
           CWL029] >gi|7189591|gb|AAF38488.1| (AE002225) pyruvate
           kinase [Chlamydophila pneumoniae AR39]
           Length = 484
           
 Score =  238 bits (601), Expect = 1e-61
 Identities = 156/464 (33%), Positives = 253/464 (53%), Gaps = 10/464 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKI+ TIGPAT+S  M+ KL++ G++V RLNFSHGS E H + I  ++++ ++    +A
Sbjct: 4   RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLA 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGD-ETTIPVEYKDFPRLVSKGDVI 128
           I+ D  G +IR+G I    + + +G+K+ L + D+ G  E  + +  K     V +G  +
Sbjct: 64  IMLDTKGPEIRLGNIPQP-ISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPFVPEGADV 122

Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
            + DGYI   V       +E   ++ G L S K ++I    + +  +T +D+  +KF +E
Sbjct: 123 LIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIRGVDVALPFMTEKDIADLKFGVE 182

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
           Q +D +  SFV    D+  ++  L       + +I+KIE    V NF +I K +DGIMIA
Sbjct: 183 QNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIMIA 242

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLG+E+ +  +P LQK + + +   G   +TATQML SM    +PTRAEV+D+ANAI 
Sbjct: 243 RGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIY 302

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           DG+ AVMLS ETA G  P+ AVK+M  +   TE+        +L +            AI
Sbjct: 303 DGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSPYLSAI 362

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
             + I      + K ++  T +G +   +S+++PK  I   + +  V   L   +GVY  
Sbjct: 363 GLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPM 422

Query: 429 CLEEGFDERDIIR---LIKGL--GLVES-DDIVLMTEGKPIEKT 466
             +E   +R + R    I G+  G++ + D I++++ G  +E+T
Sbjct: 423 LTQE--SDRAVWRHQACIYGIEQGILSNYDRILVLSRGACMEET 464


>sp|Q40545|KPYA_TOBAC PYRUVATE KINASE ISOZYME A, CHLOROPLAST PRECURSOR
           >gi|482936|emb|CAA82222.1| (Z28373) pyruvate kinase;
           plastid isozyme [Nicotiana tabacum]
           Length = 593
           
 Score =  236 bits (597), Expect = 3e-61
 Identities = 152/468 (32%), Positives = 252/468 (53%), Gaps = 25/468 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TK++ TIGPAT     +++L E G++V R+N  HG+ E H  VIE++R ++++    VA
Sbjct: 115 RTKLICTIGPATCGFEQLERLAEGGMNVARINMCHGTREWHRMVIERLRRLNEEKGFAVA 174

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGD 126
           I+ D  G +I +G++ G    + + GE    T R  D    E T+ V Y  F   V  GD
Sbjct: 175 IMMDTEGSEIHMGDLGGASSAKAEDGEIWNFTVRSFDPPLPERTVTVNYDGFAEDVKVGD 234

Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKL-------FSRKGINIPKAYLPVEAVTPRD 179
            + +  G +   V E  G DV+ +    G L       F R G  + +    +  ++ +D
Sbjct: 235 ELLVDGGMVRFEVIEKIGPDVKCLCTDPGLLLPRANLTFWRDGKLVRERNAMLPTISSKD 294

Query: 180 MEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEI 238
              I F I +GVD I +SFV S   +  +KS+++    + D+ VI+KIE  D+++N +EI
Sbjct: 295 WLDIDFGIAEGVDFIAVSFVKSAEVIKHLKSYIQARARDSDISVIAKIESIDSLKNLEEI 354

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           ++ASDG M+ARGDLG ++P+E++P  Q+++++      +PVI A+Q+L SM    +PTRA
Sbjct: 355 IQASDGAMVARGDLGAQIPLEQVPSEQQKIVQICRQLNRPVIVASQLLESMIEYPIPTRA 414

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIA-KVTEEYRESFGMSRLRELVE 357
           EV DV+ A+    DA+MLS E+A+G+FP  A+ ++  ++ ++   +RE     +  E++E
Sbjct: 415 EVADVSEAVRQRGDALMLSGESAMGQFPEKALTVLRSVSLRIERMWRE----QKRHEVIE 470

Query: 358 -----DGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTN 412
                     +I E I  S       L +  +   T+ G  A L+SR +P   IF F+T 
Sbjct: 471 LPSIASSFSDSISEEICNSAAKMANNLEVDALFVYTKNGHMASLLSRCRPDCPIFAFTTT 530

Query: 413 ERVCNNLMFSYGVYAFCLEEGFDERDIIR----LIKGLGLVESDDIVL 456
             V   L   +G+  F L    D    +     L+K  G+++S D+++
Sbjct: 531 TSVRRRLNLQWGLMPFRLSFSDDMESNLNKTFSLLKARGMIKSGDLII 578


>pir||S51946 pyruvate kinase (EC 2.7.1.40) A, chloroplast - common tobacco
           Length = 593
           
 Score =  236 bits (597), Expect = 3e-61
 Identities = 152/468 (32%), Positives = 252/468 (53%), Gaps = 25/468 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TK++ TIGPAT     +++L E G++V R+N  HG+ E H  VIE++R ++++    VA
Sbjct: 115 RTKLICTIGPATCGFEQLERLAEGGMNVARINMCHGTREWHRMVIERLRRLNEEKGFAVA 174

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGD 126
           I+ D  G +I +G++ G    + + GE    T R  D    E T+ V Y  F   V  GD
Sbjct: 175 IMMDTEGSEIHMGDLGGASSAKAEDGEIWNFTVRSFDPPLPERTVTVNYDGFAEDVKVGD 234

Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKL-------FSRKGINIPKAYLPVEAVTPRD 179
            + +  G +   V E  G DV+ +    G L       F R G  + +    +  ++ +D
Sbjct: 235 ELLVDGGMVRFEVIEKIGPDVKCLCTDPGLLLPRANLTFWRDGKLVRERNAMLPTISSKD 294

Query: 180 MEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEI 238
              I F I +GVD I +SFV S   +  +KS+++    + D+ VI+KIE  D+++N +EI
Sbjct: 295 WLDIDFGIAEGVDFIAVSFVKSAEVIKHLKSYIQARARDSDISVIAKIESIDSLKNLEEI 354

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           ++ASDG M+ARGDLG ++P+E++P  Q+++++      +PVI A+Q+L SM    +PTRA
Sbjct: 355 IQASDGAMVARGDLGAQIPLEQVPSEQQKIVQICRQLNRPVIVASQLLESMIEYPIPTRA 414

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIA-KVTEEYRESFGMSRLRELVE 357
           EV DV+ A+    DA+MLS E+A+G+FP  A+ ++  ++ ++   +RE     +  E++E
Sbjct: 415 EVADVSEAVRQRGDALMLSGESAMGQFPEKALTVLRSVSLRIERMWRE----QKRHEVIE 470

Query: 358 -----DGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTN 412
                     +I E I  S       L +  +   T+ G  A L+SR +P   IF F+T 
Sbjct: 471 LPSIASSFSDSISEEICNSAAKMANNLEVDALFVYTKNGHMASLLSRCRPDCPIFAFTTT 530

Query: 413 ERVCNNLMFSYGVYAFCLEEGFDERDIIR----LIKGLGLVESDDIVL 456
             V   L   +G+  F L    D    +     L+K  G+++S D+++
Sbjct: 531 TSVRRRLNLQWGLMPFRLSFSDDMESNLNKTFSLLKARGMIKSGDLII 578


>dbj|BAA98307.1| (AP002545) pyruvate kinase [Chlamydophila pneumoniae J138]
           Length = 484
           
 Score =  236 bits (595), Expect = 5e-61
 Identities = 156/464 (33%), Positives = 252/464 (53%), Gaps = 10/464 (2%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKI+ TIGPAT+S  M+ KL++ G++V RLNFSHGS E H + I  ++++ ++    +A
Sbjct: 4   RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLA 63

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGD-ETTIPVEYKDFPRLVSKGDVI 128
           I+ D  G +IR+G I    + + +G+K+ L + D+ G  E  + +  K     V +G  +
Sbjct: 64  IMLDTKGPEIRLGNIPQP-ISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPFVPEGADV 122

Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
            + DGYI   V       +E   ++ G L S K ++I    + +  +T +D+  +KF +E
Sbjct: 123 LIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIRGVDVALPFMTEKDIADLKFGVE 182

Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
           Q +D    SFV    D+  ++  L       + +I+KIE    V NF +I K +DGIMIA
Sbjct: 183 QNMDVNAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIMIA 242

Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
           RGDLG+E+ +  +P LQK + + +   G   +TATQML SM    +PTRAEV+D+ANAI 
Sbjct: 243 RGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIY 302

Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
           DG+ AVMLS ETA G  P+ AVK+M  +   TE+        +L +            AI
Sbjct: 303 DGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSPYLSAI 362

Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
             + I      + K ++  T +G +   +S+++PK  I   + +  V   L   +GVY  
Sbjct: 363 GLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPM 422

Query: 429 CLEEGFDERDIIR---LIKGL--GLVES-DDIVLMTEGKPIEKT 466
             +E   +R + R    I G+  G++ + D I++++ G  +E+T
Sbjct: 423 LTQE--SDRAVWRHQACIYGIEQGILSNYDRILVLSRGACMEET 464


>sp|P55964|KPYG_RICCO PYRUVATE KINASE ISOZYME G, CHLOROPLAST
           Length = 418
           
 Score =  235 bits (594), Expect = 7e-61
 Identities = 156/424 (36%), Positives = 235/424 (54%), Gaps = 16/424 (3%)

Query: 61  SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120
           +Q  D  V+I+ D  G ++R G++      LK G++   T R  V  + T+ V Y DF  
Sbjct: 2   AQSHDNVVSIMLDTKGPEVRSGDVPQPM--LKEGQEFNPTIRRGVSTQDTVSVNYDDFVN 59

Query: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
            V  GD++ +  G + L V+      V+ VVV GG+L SR+ +N+      + ++T +D 
Sbjct: 60  DVVVGDILLVDGGMMSLAVKSKTSDLVKCVVVDGGELKSRRHLNVRGKSARLPSITDKDW 119

Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
             IKF ++  VD   +SFV     V ++K +L++ +A D+ VI KIE  D++ N   I+ 
Sbjct: 120 GDIKFGVDNQVDFYAVSFVKDAKVVHELKEYLKRCNA-DIHVIVKIESADSIPNLHSIIS 178

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
           ASDG M+ARGDLG E+PIE +P+LQ+++IR+ ++  KPVI AT ML SM     PTRAEV
Sbjct: 179 ASDGAMVARGDLGAELPIEEVPLLQEDIIRRCHSMQKPVIVATNMLESMINHPTPTRAEV 238

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
           +D+A A+ +G DAVMLS ETA GK+P+ AV++M  +A  T    ES          +   
Sbjct: 239 SDIAIAVREGADAVMLSGETAHGKYPLKAVRVMHTVALRT----ESSSPVNTTPPAQGAY 294

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
           +G + E  A        TLN   I+  TRTG  A L+S ++P   IF F+  ER+   L 
Sbjct: 295 KGHMGEMFAFHATIMANTLNTP-IIVFTRTGSMAVLLSHYQPASTIFAFTNEERIKQRLS 353

Query: 421 FSYGV------YAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEG-KPIEKTMGTNSIK 473
              GV      ++   EE F     + L KGL LVE + + L+  G +PI +   T+ I+
Sbjct: 354 LYRGVMPIYMEFSSDAEETFSRALQLLLNKGL-LVEGEHVTLVQSGAQPIWRQESTHHIQ 412

Query: 474 IFQI 477
           + ++
Sbjct: 413 VRKV 416


>sp|Q43117|KPYA_RICCO PYRUVATE KINASE ISOZYME A, CHLOROPLAST PRECURSOR
           >gi|7434456|pir||T10051 pyruvate kinase (EC 2.7.1.40) -
           castor bean >gi|169703|gb|AAA33870.1| (M64736)
           ATP:pyruvate phosphotransferase [Ricinus communis]
           Length = 583
           
 Score =  235 bits (592), Expect = 1e-60
 Identities = 154/464 (33%), Positives = 243/464 (52%), Gaps = 17/464 (3%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TK+V TIGPAT     ++ L   G++V R+N  HG+ E H  VIE+VR ++++    VA
Sbjct: 105 RTKLVCTIGPATCGFEELEALAVGGMNVARINMCHGTREWHKSVIERVRRLNEEKGFAVA 164

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGD 126
           I+ D  G +I +G++ G    + + GE    + R  D    E TI V Y  F   V  GD
Sbjct: 165 IMMDTEGSEIHMGDLGGASSAKAEDGEIWTFSVRAYDSPRPERTINVNYDGFAEDVKVGD 224

Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKL-------FSRKGINIPKAYLPVEAVTPRD 179
            + +  G +   V E  G DV+      G L       F R G  + +    +  ++ +D
Sbjct: 225 ELLVDGGMVRFEVIEKIGPDVKCRCTDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKD 284

Query: 180 MEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEI 238
              I F I +GVD I +SFV S   +  +KS++     + D+ VI+KIE  D+++N +EI
Sbjct: 285 WLDIDFGIAEGVDFIAISFVKSAEVINHLKSYIAARSRDSDIAVIAKIESIDSLKNLEEI 344

Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
           ++ASDG M+ARGDLG ++P+E++P  Q+ +++      KPVI A+Q+L SM     PTRA
Sbjct: 345 IRASDGAMVARGDLGAQIPLEQVPSAQQNIVQVCRQLNKPVIVASQLLESMIEYPTPTRA 404

Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
           EV DV+ A+    DA+MLS E+A+G++P  A+ ++  ++   E++          EL   
Sbjct: 405 EVADVSEAVRQRADALMLSGESAMGQYPEKALAVLRSVSVRIEKWWREEKHHEAMELPAI 464

Query: 359 GT--RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVC 416
           G+    +I E I  S       L +  +   T+ G  A L+SR +P   IF F+T   V 
Sbjct: 465 GSTYSDSISEEICNSAAKMANNLGVDALFVYTKDGHMASLLSRCRPDCPIFAFTTTTSVR 524

Query: 417 NNLMFSYGVYAFCLEEGFDERDIIR----LIKGLGLVESDDIVL 456
             L   +G+  F L    D    +     L+K  G+++S D+V+
Sbjct: 525 RRLNLQWGLIPFRLSFADDMESNLNKTFSLLKARGMIKSGDLVI 568


>gb|AAA27629.1| (M98350) pyruvate kinase-like protein [unidentified bacterium]
           Length = 391
           
 Score =  234 bits (590), Expect = 2e-60
 Identities = 139/375 (37%), Positives = 215/375 (57%), Gaps = 10/375 (2%)

Query: 106 GDETTIPVEYKDFPRLVSKGDVIYLSDGYIVLRV--EEVRGQDVEAVVVSGGKLFSRKGI 163
           G +  I V Y      V  G  +   DG +   V  ++V  +++   V + G L SRKG+
Sbjct: 18  GTKEKIAVTYAGLFDDVQVGGQVLFDDGLLGTTVLEKDVANRELVVRVDNDGILGSRKGV 77

Query: 164 NIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVI 223
           N P   + +  +T +D + I+F ++ G++ I  SFV    DVL+++  L++ + E V ++
Sbjct: 78  NAPGVSINLPGITEKDADDIRFGLDHGINYIAASFVRKPEDVLEIRGLLKEKNMEHVQIV 137

Query: 224 SKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITAT 283
            KIE  + + N D I+  SDG+M+ RGD+GVE+P E +P++QKE+IRK N  G PVITAT
Sbjct: 138 PKIESQEGIDNLDAIIAVSDGLMVPRGDMGVEIPAENVPLVQKEMIRKMNLAGLPVITAT 197

Query: 284 QMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEY 343
           QML SM     PTRAE +DVANA+ DGTDA MLS E+A G++P++AV  MA I +  E  
Sbjct: 198 QMLDSMEENPRPTRAEASDVANAVFDGTDATMLSGESANGEYPVEAVATMAAIDEKAESS 257

Query: 344 RESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPK 403
              +G  R ++L  D T  T  EA+A ++     ++N K I+  T +G TA ++S+++P+
Sbjct: 258 LPYYG--RHQDLHFDETDST--EAVASAVSRIAHSVNAKAIVVSTNSGYTACMVSKYRPE 313

Query: 404 QWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRL----IKGLGLVESDDIVLMTE 459
             I   + +ERV   L  +YGV     E      ++I L    +K  GL  S D +++  
Sbjct: 314 VNILAVTYSERVQRGLTLNYGVLPVVYEAPATIDEMIALAKTAVKEQGLANSGDTIVIAA 373

Query: 460 GKPIEKTMGTNSIKI 474
           G P+ ++  TN I +
Sbjct: 374 GVPMSQSGTTNMITV 388


>sp|P47458|KPYK_MYCGE PYRUVATE KINASE (PK) >gi|1361781|pir||H64223 pyruvate kinase (EC
           2.7.1.40) - Mycoplasma genitalium
           >gi|3844816|gb|AAC71435.1| (U39701) pyruvate kinase
           (pyk) [Mycoplasma genitalium]
           Length = 508
           
 Score =  219 bits (551), Expect = 7e-56
 Identities = 150/479 (31%), Positives = 254/479 (52%), Gaps = 47/479 (9%)

Query: 8   DH--KTKIVATIGPATSSRNM--------------------IKKLIENGVSVVRLNFSHG 45
           DH  +TKI+AT GPA +   +                    I+ +I++GVSV+RLNFSHG
Sbjct: 3   DHLKRTKIIATCGPALTKSLVSLKMLDDNEYAAIKKVAYANIEAIIKSGVSVIRLNFSHG 62

Query: 46  SFEEHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRD-V 104
           + EE    I+ VRD+++ ++  V+I+ D  G +IR+ E K   +++ +  +V++ T   +
Sbjct: 63  THEEQQVRIKIVRDVAKAMNIPVSIMLDTNGPEIRIVETKKEGLKITKDSEVIINTMSKM 122

Query: 105 VGDETTIPVEYK----DFPRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGK--LF 158
           +  +    V       +    V+ G  I + DG + L V  V  Q  + + V+     +F
Sbjct: 123 IASDNQFAVSDASGKYNMVNDVNIGQKILVDDGKLTLVVTRVDKQHNQVICVAKNDHTVF 182

Query: 159 SRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE 218
           ++K +N+P A   +  ++ +D++ I F + QG+D I  SFV +V D+ +++ +L+  +A 
Sbjct: 183 TKKRLNLPNAQYSIPFLSEKDLKDIDFGLSQGIDYIAASFVNTVADIKQLRDYLKLKNAS 242

Query: 219 DVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKP 278
            V +I+KIE   A+ N D+I+KASDGIM+ARGDLG+E+P  ++P  Q+ +I+      K 
Sbjct: 243 GVKIIAKIESNHALNNIDKIIKASDGIMVARGDLGLEIPYYQVPYWQRYMIKACRFFNKR 302

Query: 279 VITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAK 338
            ITATQML S+     PTRAEVTDV  A+  G DA MLS ETA G +P++AV +M KI K
Sbjct: 303 SITATQMLDSLEKNIQPTRAEVTDVYFAVDRGNDATMLSGETASGLYPLNAVAVMQKIDK 362

Query: 339 VTEEY------------RESFGMSRL-RELVEDGTRGTIKEAIARSIIDALCTLNIKYIL 385
            +E +              +   SR    +V   T+ T+ +   R ++++       +I+
Sbjct: 363 QSETFFDYQYNVNYYLKNSTANKSRFWHNVVLPLTKKTVPK---RKLVNS--AFKYDFIV 417

Query: 386 TPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIK 444
            PT        +S  +    +   + N+RV       YG++ + +++  ++     LI+
Sbjct: 418 YPTNNINRIYALSNARLAAAVIILTNNKRVYTGHGVDYGIFCYLIDKNPNQLTKAELIE 476


>pir||T47720 pyruvate kinase-like protein - Arabidopsis thaliana
           >gi|7263569|emb|CAB81606.1| (AL161667) pyruvate
           kinase-like protein [Arabidopsis thaliana]
           Length = 492
           
 Score =  218 bits (550), Expect = 1e-55
 Identities = 142/405 (35%), Positives = 226/405 (55%), Gaps = 39/405 (9%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV T+GP + S  MI+KL++                  A+ ++ +R          A
Sbjct: 17  KTKIVCTLGPVSRSVEMIEKLLK------------------AETLDNLRTAMNNTGILCA 58

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
           ++ D  G +IR G +K G  ++L +G+++ ++    + GD   I + YK     V  GDV
Sbjct: 59  VMLDTKGPEIRTGFLKEGKPIQLNQGQEITISIDYKIEGDSNIISMSYKKLAEDVKPGDV 118

Query: 128 IYLSDGYI---VLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
           I  SDG I   VL  ++  G  V     +   L  RK +N+P   + +  +T +D E II
Sbjct: 119 ILCSDGTISLTVLSCDKSFGL-VRCRCENSTILGERKNVNLPGIVVDLPTLTEKDKEDII 177

Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
           ++ +   +D I LSFV    D+ +V+  L ++ ++++ ++SK+E  + V N ++IL+ SD
Sbjct: 178 QWGVPNKIDIIALSFVRKGSDLTEVRKLLGEH-SKNIMLMSKVENQEGVMNCEKILENSD 236

Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
             M+ARGDLG+E+ IE++ + QK +I+ AN  GKPV+TATQML SMT    PTRAE TDV
Sbjct: 237 AFMVARGDLGMEIQIEKMFLAQKTMIKMANALGKPVVTATQMLESMTVSPRPTRAEATDV 296

Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
           ANA+LDGTD VMLS ETA G  P  AV  M++I K  E++ +        +++   T G 
Sbjct: 297 ANAVLDGTDCVMLSGETAAGAHPEAAVLTMSRICKEAEDFID-------YDILHKKTLGM 349

Query: 364 IK------EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
           +       E++A S++    ++    I+  T+ G TA L+++++P
Sbjct: 350 LSLPLSPIESLAASVVSTAQSVFASAIVVLTKGGYTAELVAKYRP 394


>pir||T10054 pyruvate kinase (EC 2.7.1.40) isoform beta - castor bean
           >gi|169705|gb|AAA33871.1| (M64737) ATP:pyruvate
           phosphotransferase [Ricinus communis]
           Length = 493
           
 Score =  214 bits (540), Expect = 1e-54
 Identities = 143/439 (32%), Positives = 228/439 (51%), Gaps = 17/439 (3%)

Query: 35  VSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGY-VELKR 93
           ++V R+N  HG+ E H  VIE+VR ++++    VAI+ D  G +I +G++ G    + + 
Sbjct: 40  MNVARINMCHGTREWHKSVIERVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGASSAKAED 99

Query: 94  GEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVV 151
           GE    + R  D    E TI V Y  F   V  GD + +  G +   V E  G DV+   
Sbjct: 100 GEIWTFSVRAYDSPRPERTINVNYDGFAEDVKVGDELLVDGGMVRFEVIEKIGPDVKCRC 159

Query: 152 VSGGKL-------FSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYD 204
              G L       F R G  + +    +  ++ +D   I F I +GVD I +SFV S   
Sbjct: 160 TDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKDWLDIDFGIAEGVDFIAISFVKSAEV 219

Query: 205 VLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPI 263
           +  +KS++     + D+ VI+KIE  D+++N +EI++ASDG M+ARGDLG ++P+E++P 
Sbjct: 220 INHLKSYIAARSRDSDIAVIAKIESIDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPS 279

Query: 264 LQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIG 323
            Q+ +++      KPVI A+Q+L SM     PTRAEV DV+ A+    DA+MLS E+A+G
Sbjct: 280 AQQNIVQVCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSGESAMG 339

Query: 324 KFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT--RGTIKEAIARSIIDALCTLNI 381
           ++P  A+ ++  ++   E++          EL   G+    +I E I  S       L +
Sbjct: 340 QYPEKALAVLRSVSVRIEKWWREEKHHEAMELPAIGSTYSDSISEEICNSAAKMANNLGV 399

Query: 382 KYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIR 441
             +   T+ G  A L+SR +P   IF F+T   V   L   +G+  F L    D    + 
Sbjct: 400 DALFVYTKDGHMASLLSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFADDMESNLN 459

Query: 442 ----LIKGLGLVESDDIVL 456
               L+K  G+++S D+V+
Sbjct: 460 KTFSLLKARGMIKSGDLVI 478


>sp|P78031|KPYK_MYCPN PYRUVATE KINASE (PK) >gi|2146579|pir||S73859 pyruvate kinase (EC
           2.7.1.40) pyk - Mycoplasma pneumoniae  (strain ATCC
           29342) >gi|1674229|gb|AAB96181.1| (AE000052) pyruvate
           kinase [Mycoplasma pneumoniae]
           Length = 508
           
 Score =  212 bits (533), Expect = 1e-53
 Identities = 136/361 (37%), Positives = 202/361 (55%), Gaps = 27/361 (7%)

Query: 10  KTKIVATIGPATSSRNM--------------------IKKLIENGVSVVRLNFSHGSFEE 49
           +TKI+AT GPA + +                      I+ +I+NGV+V+RLNFSHG+ EE
Sbjct: 7   RTKIIATCGPALTKKLWTLAMLDDPAYAAMKAEAYANIENIIKNGVTVIRLNFSHGNHEE 66

Query: 50  HAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKG-GYVELKRGEKVVLTTRDVVGDE 108
            A  I+ VRD+++KL+  V+I+ D  G +IRV E    G   LK  E V+ TT   V   
Sbjct: 67  QAVRIKIVRDVAKKLNLPVSIMLDTNGPEIRVFETAPEGLKILKDSEVVINTTTKEVAKN 126

Query: 109 TTIPVEYK----DFPRLVSKGDVIYLSDGYIVLRVEEV--RGQDVEAVVVSGGKLFSRKG 162
               V       +    V  G  I + DG + L V+ +  +   V  V  +   +F++K 
Sbjct: 127 NQFSVSDASGTYNMVNDVKVGQKILVDDGKLSLVVKRIDTKNNQVICVAQNDHTIFTKKR 186

Query: 163 INIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFV 222
           +N+P A   +  ++ +D+  I F +   +D I  SFV +  ++ +++ +L   +A+ V +
Sbjct: 187 LNLPNADYSIPFLSAKDLRDIDFGLTHQIDYIAASFVNTTENIKQLRDYLASKNAKHVKL 246

Query: 223 ISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITA 282
           I+KIE   A+ N D I+KASDGIM+ARGDLG+E+P  ++P  Q+ +I+      K VITA
Sbjct: 247 IAKIESNHALNNIDGIIKASDGIMVARGDLGLEIPYYKVPYWQRYMIKACRFFNKRVITA 306

Query: 283 TQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE 342
           TQML S+     PTRAEVTDV  A+  G DA MLS ETA G FP++AV +M  I K +E 
Sbjct: 307 TQMLDSLEKNIQPTRAEVTDVYFAVDRGNDATMLSGETANGAFPLNAVYVMKMIDKQSET 366

Query: 343 Y 343
           +
Sbjct: 367 F 367


>dbj|BAA15445.1| (D90810) Pyruvate kinase (EC 2.7.1.40) I [Escherichia coli]
           Length = 264
           
 Score =  210 bits (528), Expect = 4e-53
 Identities = 106/262 (40%), Positives = 165/262 (62%), Gaps = 2/262 (0%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           KTKIV TIGP T S  M+ K+++ G++V+RLNFSHG + EH + I+ +R++  K  +  A
Sbjct: 3   KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62

Query: 70  ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
           IL D  G +IR  +++GG  V LK G+    TT + V+G+   + V Y+ F   +S G+ 
Sbjct: 63  ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122

Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
           + + DG I + V  + G  V   V++ G L   KG+N+P   + + A+  +D + + F  
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182

Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
           EQGVD +  SF+    DV++++  L+ +  E++ +ISKIE  + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242

Query: 248 ARGDLGVEMPIERLPILQKELI 269
           ARGDLGVE+P+E +   QK +I
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMI 264


>pir||T47556 pyruvate kinase-like protein - Arabidopsis thaliana
           >gi|7529723|emb|CAB86903.1| (AL132969) pyruvate
           kinase-like protein [Arabidopsis thaliana]
           Length = 514
           
 Score =  199 bits (501), Expect = 5e-50
 Identities = 138/476 (28%), Positives = 244/476 (50%), Gaps = 36/476 (7%)

Query: 11  TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
           TKIV T+GP + S   +   ++ G+SV R +FS G  + H + ++ ++   +   +  A+
Sbjct: 17  TKIVGTLGPKSRSVEALSGCLKAGMSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAV 76

Query: 71  LADLPGLKIRVGEIKGGYVELKRGEKVVLT-TRDVVGDETTIPVEYKDFPRLVSKGDVI- 128
           + D  G +++V       + LK    V LT  +D       +P+ +    + V KGD I 
Sbjct: 77  MLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVLPINFNGLAKAVKKGDTIF 136

Query: 129 ---YLSDGY----IVLRVEEVRGQDVEAV----VVSGGKLFSRKGINIPKAYLPVEAVTP 177
              YL  G     + L V+EV+G DV  +        G LF+   ++  + ++ +  +T 
Sbjct: 137 VGQYLFTGSETTSVWLEVDEVKGDDVICLSRNAATLAGSLFT---LHSSQVHIDLPTLTE 193

Query: 178 RDMEIIK-FAIEQGVDAIGLSFVGSVYDVLKVKSFLEK-NDAEDVFVISKIERPDAVRNF 235
           +D E+I  + ++  +D + LS+     DV + +  L+K  D     + +KIE  + + +F
Sbjct: 194 KDKEVISTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDLSQTQIFAKIENVEGLTHF 253

Query: 236 DEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVP 295
           DEIL+ +DGI+++RG+LG+++P E++ + QK  + K N  GKP +  T+++ SMT    P
Sbjct: 254 DEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-LTRVVDSMTDNLRP 312

Query: 296 TRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI-AKVTEEYRESFGMSRLRE 354
           TRAE TDVANA+LDG+DA++L  ET  G +P++ +  + +I A+  + + +     +  +
Sbjct: 313 TRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVK 372

Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
            V  G   T  E+IA S + A   +    I+  T +GR ARLI++++P   +        
Sbjct: 373 YV--GEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRV 430

Query: 415 VCNNLMFSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTN 470
             N L +S+          F+ R  + +++GL  + +D         P E T  TN
Sbjct: 431 KTNQLKWSF-------SGAFEARQSL-IVRGLFPMLAD------PRHPAESTSATN 472


>gb|AAD24640.1|AC006919_20 (AC006919) putative pyruvate kinase [Arabidopsis thaliana]
           Length = 464
           
 Score =  178 bits (446), Expect = 2e-43
 Identities = 128/448 (28%), Positives = 223/448 (49%), Gaps = 38/448 (8%)

Query: 35  VSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVELKRG 94
           +SV R +FS    + H + +E ++   +   +  A++ D  G +++V       + LK  
Sbjct: 1   MSVARFDFSWCDADYHQETLENLKIAVKSTKKLCAVMLDTVGPELQVINKTEKAISLKAD 60

Query: 95  EKVVLT-TRDVVGDETTIPVEYKDFPRLVSKGDVI----YLSDGYIVLRVEEVRGQDVEA 149
             V LT ++D       +P+ +    + V KGD I    YL  G     VEEV+G DV  
Sbjct: 61  GLVTLTPSQDQEASSEVLPINFDGLAKAVKKGDTIFVGQYLFTGSETTSVEEVKGDDVIC 120

Query: 150 V----VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK-FAIEQGVDAIGLSFVGSVYD 204
           +       GG LF+   +++ + ++ +  +T +D E+I  + ++  +D + LS+     D
Sbjct: 121 ISRNAATLGGPLFT---LHVSQVHIDMPTLTEKDKEVISTWGVQNKIDFLSLSYCRHAED 177

Query: 205 VLKVKSFLEK-NDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPI 263
           V + +  L    D     + +KIE  + + +FDEIL+ +DGI+++RG+LG+++P E    
Sbjct: 178 VRQARELLNSCGDLSQTQIFAKIENEEGLTHFDEILQEADGIILSRGNLGIDLPPE---- 233

Query: 264 LQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIG 323
             K  + K N  GKP +  T+++ SMT    PTRAE TDVANA+LDG+DA++L  ET  G
Sbjct: 234 --KAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRG 290

Query: 324 KFPIDAVKMMAKIAKVTEE-YRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIK 382
            +P++ +  + +I    E+ + +     +  + V  G   T  E+IA S + A   +   
Sbjct: 291 LYPVETISTVGRICCEAEKVFNQDLFFKKTVKYV--GEPMTHLESIASSAVRAAIKVKAS 348

Query: 383 YILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRL 442
            I+  T +GR ARLI++++P   +          N L +S+          F+ R  + +
Sbjct: 349 VIICFTSSGRAARLIAKYRPTMPVLSVVIPRLTTNQLKWSF-------SGAFEARQSL-I 400

Query: 443 IKGLGLVESDDIVLMTEGKPIEKTMGTN 470
           ++GL  + +D         P E T  TN
Sbjct: 401 VRGLFPMLAD------PRHPAESTSATN 422


>pir||B82923 pyruvate kinase UU186 [imported] - Ureaplasma urealyticum
           >gi|6899150|gb|AAF30593.1|AE002118_3 (AE002118) pyruvate
           kinase [Ureaplasma urealyticum]
           Length = 474
           
 Score =  176 bits (441), Expect = 6e-43
 Identities = 118/360 (32%), Positives = 198/360 (54%), Gaps = 31/360 (8%)

Query: 10  KTKIVATIGPATSS-----------RNM---------IKKLIENGVSVVRLNFSHGSFEE 49
           KT+I+AT+GPAT+             N+         IK LI +GV++ R+N SHG  + 
Sbjct: 4   KTRIIATVGPATTKLFSNWLEFNDLNNINDAQQVCINIKDLILSGVNIFRMNLSHGDQKI 63

Query: 50  HAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET 109
           H    + ++ I+ +L  +V IL D  G +IRV E+      +K  E ++     V+G   
Sbjct: 64  HLFRTQLIKKIADELKIKVEILFDTKGPEIRVCEMSDNNFIIKNSEVIIHCKEKVLGSFN 123

Query: 110 TIPV-EYKDFPRLVSKGDV---IYLSDGYIVLRVEEVRGQDVEAVVVSGGK----LFSRK 161
              V +      ++S   +   I + DG ++L V+++    ++ ++ +  K    L + K
Sbjct: 124 EFSVTDATGQYNMISDVKINHRILIDDGKLILIVKKI--DFLKNIIYTTAKNSYSLKTNK 181

Query: 162 GINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVF 221
            +N+P A   +  ++ +D++ I  A++  +  + LSF+ ++  + +VK  L+K+      
Sbjct: 182 RLNLPDANYSLPFLSKKDIDDINLAVKLKIPYLALSFISNIKQINEVKQLLKKSSFIPK- 240

Query: 222 VISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVIT 281
           +I+KIE  +A+ N +EI+K +DGIM+ARGDLG+E+P  ++PI Q +++   +   K  I 
Sbjct: 241 LIAKIETQEAIDNLEEIIKNTDGIMVARGDLGLEVPFYKIPIYQNKIVELCHKYNKYCII 300

Query: 282 ATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE 341
           ATQML S+    +PTRAEVTDV  A+    +A MLS ETA G  PI+AV++M  I   TE
Sbjct: 301 ATQMLDSLERNIIPTRAEVTDVYYAVKQKVNATMLSGETAAGIDPINAVQVMKSIILETE 360


>sp|O30853|KPY1_PHOLE PYRUVATE KINASE I (PK-1) >gi|7434445|pir||PC4418 pyruvate kinase
           (EC 2.7.1.40) I - Photobacterium leiognathi  (fragment)
           >gi|2407666|gb|AAC45776.1| (AF019143) pyruvate kinase I
           [Photobacterium leiognathi]
           Length = 235
           
 Score =  153 bits (384), Expect = 3e-36
 Identities = 100/240 (41%), Positives = 132/240 (54%), Gaps = 12/240 (5%)

Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
           ASDGIM+ARGDLGVE+P+E +   QK +I K N   K VITATQML SM     PTRAE 
Sbjct: 1   ASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEA 60

Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
            DVANAI+DGTDAVMLS E+A GK+PI+AV +MA+I   T++  +    SRL     D  
Sbjct: 61  GDVANAIMDGTDAVMLSGESAKGKYPIEAVTIMAQICARTDDVVKPELGSRL-----DSP 115

Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
           R  I EA+ +  +D    LN   I+  T  G++AR + ++ P   I   +TN +    L 
Sbjct: 116 RLRITEAVCKGAVDTAEKLNAPLIIVATEAGKSARSVRKYFPTARILAVTTNTKTAAQLC 175

Query: 421 FSYGVYAFCLEEGFDERDII-----RLIKGLGLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
            S GV    + +  +  D        L    GL    DIV+M  G  +   T  T S+ +
Sbjct: 176 LSKGVTPVVV-DSIESTDAFYLRGKELALETGLGAKGDIVVMVSGALVASGTTNTASVHV 234


>gb|AAF19604.1|AF150875_1 (AF150875) pyruvate kinase [Giardia intestinalis]
           Length = 517
           
 Score =  146 bits (364), Expect = 6e-34
 Identities = 109/396 (27%), Positives = 195/396 (48%), Gaps = 21/396 (5%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           + K++A++GP+ ++   I ++I +G    R+  +  S EE+ ++   VR  +    + ++
Sbjct: 39  RAKVIASLGPSCNTEGSIAQMIRHGADAFRIVMAKASNEENIRLYNLVRKCAADQKKHIS 98

Query: 70  ILADLPGLKIRVGEIKG--GYVELKRGEKVVLTTRDVVGDET--TIPVEYKDFPRLVSKG 125
           I+A L G K RV   +     + L+ G ++ +     +  +   T+ V   +   ++  G
Sbjct: 99  IIASLQGPKFRVTRFRNTTNSITLQEGSELNIMFNKAMECDAPNTVFVNESEIFTVIEVG 158

Query: 126 DVIYLSDGYIVLRVEEVRGQ--DVEAVVVSGG--KLFSRKGINIPKAYLPVEAVTPRDME 181
           D +   +G ++ +V  V     +V+AVV + G  KL+    + IP     +  +T  + E
Sbjct: 159 DEVVFKNGPLIAKVTSVSPDKTNVKAVVTTRGSTKLYGGSSLRIPSKLSSIAPLTSLEYE 218

Query: 182 IIKFAIEQ-GVDAIGLSFVGSVYDVLKVKS---FLEKNDAE-DVFVISKIERPDAVRNFD 236
            +    E+  VD I  S + +  D+  +++   FL K   +    +++K+E P AV N  
Sbjct: 219 HLHLLAEKMPVDWICYSHINTESDIKHIENYTDFLSKKYPDFRPMLMTKVETPLAVLNLK 278

Query: 237 EILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPT 296
           +I+   DGIMIARG LG EM    LP +QK +I+ A   GK    AT +  SM+   +PT
Sbjct: 279 QIVTHVDGIMIARGALGDEMDFSYLPSIQKSIIQIARDSGKMCYIATNVCESMSENVIPT 338

Query: 297 RAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE------EYRES--FG 348
           RAEV+DV N + DG D  +L  ET+ G   +  VK + +I    E       YR    F 
Sbjct: 339 RAEVSDVTNCLGDGCDGFVLCAETSTGHHSVATVKYLVEIIVAVENDPLDVSYRSKVLFS 398

Query: 349 MSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYI 384
            +  ++ ++  ++  + ++I+ S I     L+ K I
Sbjct: 399 GTTRKQPLKTDSQHRLPDSISVSAISLASILDAKCI 434


>dbj|BAA16043.1| (D90853) Pyruvate kinase (EC 2.7.1.40) I [Escherichia coli]
           Length = 198
           
 Score =  118 bits (293), Expect = 1e-25
 Identities = 75/184 (40%), Positives = 103/184 (55%), Gaps = 9/184 (4%)

Query: 277 KPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI 336
           K VITATQML SM     PTRAE  DVANAILDGTDAVMLS E+A GK+P++AV +MA I
Sbjct: 8   KVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATI 67

Query: 337 AKVTEEYRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARL 396
            + T+       M+   E   D  +  I EA+ R  ++    L+   I+  T+ G++AR 
Sbjct: 68  CERTDRV-----MNSRLEFNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARA 122

Query: 397 ISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIKGL----GLVESD 452
           + ++ P   I   +TNE+  + L+ S GV    ++E     D  RL K L    GL    
Sbjct: 123 VRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKG 182

Query: 453 DIVL 456
           D+V+
Sbjct: 183 DVVV 186


>gb|AAB69999.1| (AF012877) pyruvate kinase [Spiroplasma citri]
           Length = 157
           
 Score = 87.4 bits (213), Expect = 3e-16
 Identities = 50/144 (34%), Positives = 81/144 (55%), Gaps = 6/144 (4%)

Query: 10  KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
           +TKI+ TIGP+T S   I++L + G++ +RLNFSHG   E    I   R++S K+ + ++
Sbjct: 12  RTKIITTIGPSTHSPGAIEELFKTGMTTIRLNFSHGDHAEQGARIVWAREVSAKIGKPIS 71

Query: 70  ILADLPGLKIRVGEIKGGYVELKRGEKVVLTT-----RDVVGDETTIPVEYKDFPRLVSK 124
           +L D  G +IR G +KGG  E+  G  V + +     ++  G  T I V Y D  + +  
Sbjct: 72  VLLDTKGPEIRAGIMKGGKQEIVAGATVTIYSLPTEYQNREGTGTEITVSY-DMSQDLKV 130

Query: 125 GDVIYLSDGYIVLRVEEVRGQDVE 148
           GDV+ + DG + L V  ++   +E
Sbjct: 131 GDVVLVDDGKLQLNVTGIKPGIIE 154


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.320    0.139    0.380 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 159376800
Number of Sequences: 2977
Number of extensions: 6617387
Number of successful extensions: 21961
Number of sequences better than 1.0e-10: 165
Number of HSP's better than  0.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 21281
Number of HSP's gapped (non-prelim): 174
length of query: 478
length of database: 189,106,746
effective HSP length: 60
effective length of query: 418
effective length of database: 153,197,526
effective search space: 64036565868
effective search space used: 64036565868
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 167 (69.5 bits)