BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1441 (pyk) DE:PYRUVATE KINASE (EC 2.7.1.40) (PK)
(478 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75052 pyruvate kinase (EC 2.7.1.40) (pk) PAB1441 - Pyrococ... 930 0.0
pir||F71171 probable pyruvate kinase - Pyrococcus horikoshii >gi... 807 0.0
dbj|BAB06882.1| (AP001517) pyruvate kinase [Bacillus halodurans] 374 e-103
pir||B72406 pyruvate kinase - Thermotoga maritima (strain MSB8) ... 357 1e-97
sp|P80885|KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE PROTEIN 17... 357 2e-97
pir||S27330 pyruvate kinase (EC 2.7.1.40) isoform 1 - Bacillus s... 356 2e-97
sp|Q02499|KPYK_BACST PYRUVATE KINASE (PK) >gi|421472|pir||S29783... 356 2e-97
sp|Q55863|KPY1_SYNY3 PYRUVATE KINASE 1 (PK 1) >gi|7434447|pir||S... 355 5e-97
gb|AAC12962.1| (U73943) pyruvate kinase I [Bacillus subtilis] 353 3e-96
sp|P51181|KPYK_BACLI PYRUVATE KINASE (PK) >gi|1361386|pir||JC422... 344 2e-93
dbj|BAA89788.1| (AB037182) pyruvate kinase [Selenomonas ruminant... 335 8e-91
sp|P51182|KPYK_BACPY PYRUVATE KINASE (PK) >gi|1363364|pir||JC421... 332 6e-90
pir||B75251 pyruvate kinase - Deinococcus radiodurans (strain R1... 332 6e-90
emb|CAB70653.1| (AL137242) pyruvate kinase [Streptomyces coelico... 332 6e-90
sp|P14178|KPY1_ECOLI PYRUVATE KINASE I (PK-1) >gi|7428041|pir||D... 328 8e-89
sp|Q56301|KPYK_THELI PYRUVATE KINASE (PK) >gi|2147994|pir||A5741... 327 2e-88
sp|P73534|KPY2_SYNY3 PYRUVATE KINASE 2 (PK 2) >gi|7434448|pir||S... 326 2e-88
pdb|1PKY|A Chain A, Pyruvate Kinase From E. Coli In The T-State ... 326 3e-88
pdb|1E0U|A Chain A, Structure R271l Mutant Of E. Coli Pyruvate K... 325 5e-88
pdb|1E0T|A Chain A, R292d Mutant Of E. Coli Pyruvate Kinase >gi|... 323 2e-87
pir||S29004 pyruvate kinase (EC 2.7.1.40) I - Escherichia coli >... 323 3e-87
sp|P77983|KPY1_SALTY PYRUVATE KINASE I (PK-1) >gi|1526982|emb|CA... 323 4e-87
dbj|BAA89378.1| (AB025342) ORF4 [Moritella marina] 318 7e-86
pir||F81382 pyruvate kinase (EC 2.7.1.40) Cj0392c [imported] - C... 314 1e-84
pir||T35759 pyruvate kinase - Streptomyces coelicolor >gi|568990... 310 3e-83
pir||C82316 pyruvate kinase I VC0485 [imported] - Vibrio cholera... 303 3e-81
sp|Q92122|KPYK_XENLA PYRUVATE KINASE, MUSCLE ISOZYME (CYTOSOLIC ... 301 1e-80
pir||T27928 hypothetical protein ZK593.1 - Caenorhabditis elegan... 300 2e-80
pir||D83459 pyruvate kinase I PA1498 [imported] - Pseudomonas ae... 298 7e-80
sp|P21599|KPY2_ECOLI PYRUVATE KINASE II (PK-2) >gi|321866|pir||S... 295 8e-79
sp|O44006|KPYK_EIMTE PYRUVATE KINASE (PK) >gi|2854033|gb|AAC0252... 294 1e-78
sp|Q44473|KPY4_AGRVI PYRUVATE KINASE (PK) >gi|805294|gb|AAA68700... 294 1e-78
sp|Q46078|KPYK_CORGL PYRUVATE KINASE (PK) >gi|2127424|pir||I4084... 293 2e-78
sp|Q29536|KPYR_CANFA PYRUVATE KINASE, ISOZYME R >gi|7579924|gb|A... 293 2e-78
gb|AAA60104.1| (M15465) pyruvate kinase [Homo sapiens] 292 5e-78
pir||T21360 hypothetical protein F25H5.3b - Caenorhabditis elega... 292 5e-78
pir||T21361 hypothetical protein F25H5.3a - Caenorhabditis elega... 292 5e-78
pir||B82130 pyruvate kinase II VC2008 [imported] - Vibrio choler... 292 5e-78
pir||S64635 pyruvate kinase (EC 2.7.1.40), muscle splice form M1... 292 7e-78
gb|AAG21457.1|AC021894_17 (AC021894) Pyruvate Kinase copy 2 [Lei... 292 7e-78
sp|P94939|KPYK_MYCIT PYRUVATE KINASE (PK) >gi|1750255|gb|AAB3921... 291 9e-78
sp|P11979|KPY1_FELCA PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINAS... 291 1e-77
sp|P34038|KPYK_LACDE PYRUVATE KINASE >gi|1154865|emb|CAA50527.1|... 291 1e-77
gb|AAA92535.1| (U47654) pyruvate kinase PK-R isoenzyme [Homo sap... 290 3e-77
gb|AAA92536.1| (U47654) pyruvate kinase PK-L isoenzyme [Homo sap... 290 3e-77
pir||A30150 pyruvate kinase (EC 2.7.1.40) isoform R (erythroid) ... 290 3e-77
gi|10835121 pyruvate kinase, liver and RBC; Pyruvate kinase, liv... 290 3e-77
pir||KIHUPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice fo... 290 3e-77
pir||KIHUPL pyruvate kinase (EC 2.7.1.40), hepatic splice form L... 290 3e-77
sp|P11980|KPY1_RAT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE ... 289 3e-77
sp|P11981|KPY2_RAT PYRUVATE KINASE, M2 ISOZYME >gi|92716|pir||A2... 289 4e-77
gb|AAA41882.1| (M17091) R-pyruvate kinase [Rattus norvegicus] 289 4e-77
gb|AAA41883.1| (M17091) L-pyruvate kinase [Rattus norvegicus] 289 4e-77
gi|6981360 pyruvate kinase, liver and RBC [Rattus norvegicus] >g... 289 6e-77
pir||A23612 pyruvate kinase (EC 2.7.1.40) L - rat >gi|206199|gb|... 289 6e-77
sp|P12928|KPYR_RAT PYRUVATE KINASE, ISOZYMES R/L (L-PK) 289 6e-77
sp|P70789|KPY3_AGRVI PYRUVATE KINASE (PK) >gi|984370|gb|AAB61625... 288 8e-77
pdb|1A49|A Chain A, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kin... 288 8e-77
sp|P11974|KPY1_RABIT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINAS... 288 8e-77
gb|AAC48536.1| (U44751) pyruvate kinase [Oryctolagus cuniculus] ... 287 1e-76
sp|O06134|KPYK_MYCTU PYRUVATE KINASE (PK) >gi|7434446|pir||G7055... 287 1e-76
sp|P14618|KPY1_HUMAN PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINAS... 287 2e-76
pir||B81239 pyruvate kinase II NMB0089 [imported] - Neisseria me... 287 2e-76
pir||KIRTPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice fo... 287 2e-76
sp|P00548|KPYK_CHICK PYRUVATE KINASE, MUSCLE ISOZYME >gi|66858|p... 287 2e-76
gi|4505839 pyruvate kinase, muscle; Pyruvate kinase-3; Thyroid h... 287 2e-76
pdb|1PKN| Pyruvate Kinase (E.C.2.7.1.40) Complexed With Mangan... 287 2e-76
gi|8567390 pyruvate kinase liver and red blood cell [Mus musculu... 287 2e-76
pdb|1PKL|G Chain G, The Structure Of Leishmania Pyruvate Kinase ... 287 2e-76
gi|6755074 pyruvate kinase 3 [Mus musculus] >gi|1405933|emb|CAA6... 286 3e-76
sp|P52480|KPY2_MOUSE PYRUVATE KINASE, M2 ISOZYME 286 3e-76
pir||A54113 pyruvate kinase (EC 2.7.1.40) - rabbit 286 4e-76
pir||A33983 pyruvate kinase (EC 2.7.1.40) isozyme M2 - human >gi... 286 5e-76
pir||S55921 pyruvate kinase (EC 2.7.1.40) isozyme M2 - mouse >gi... 286 5e-76
pir||G82011 pyruvate kinase (EC 2.7.1.40) NMA0177 [imported] - N... 285 7e-76
sp|P30614|KPYK_YARLI PYRUVATE KINASE >gi|424047|gb|AAA18520.1| (... 284 1e-75
gb|AAB86587.1| (AF032389) pyruvate kinase; ATP:pyruvate 2-o-phos... 284 1e-75
sp|O18919|KPY2_RABIT PYRUVATE KINASE, M2 ISOZYME 284 1e-75
sp|Q27686|KPYK_LEIME PYRUVATE KINASE (PK) >gi|577072|emb|CAA5289... 283 3e-75
sp|Q40546|KPYG_TOBAC PYRUVATE KINASE ISOZYME G, CHLOROPLAST PREC... 282 6e-75
pir||E82757 pyruvate kinase type II XF0824 [imported] - Xylella ... 282 6e-75
dbj|BAB12236.1| (AB032276) pyruvate kinase [Aspergillus oryzae] 282 7e-75
sp|O51323|KPYK_BORBU PYRUVATE KINASE (PK) >gi|7434449|pir||C7014... 279 4e-74
sp|Q57572|KPYK_METJA PYRUVATE KINASE (PK) >gi|2129228|pir||D6431... 279 6e-74
sp|P22360|KPYK_EMENI PYRUVATE KINASE (PK) >gi|283342|pir||S27364... 277 2e-73
gb|AAK41255.1| Pyruvate kinase (pyK) [Sulfolobus solfataricus] 276 3e-73
pir||S26869 pyruvate kinase (EC 2.7.1.40) pkiA - Aspergillus niger 275 7e-73
sp|Q12669|KPYK_ASPNG PYRUVATE KINASE (PK) >gi|250607|gb|AAB22392... 274 2e-72
dbj|BAB10461.1| (AB005234) pyruvate kinase [Arabidopsis thaliana] 274 2e-72
sp|O65595|KPYC_ARATH PROBABLE PYRUVATE KINASE, CYTOSOLIC ISOZYME... 272 5e-72
gb|AAF81342.1|AC007767_22 (AC007767) Strong similarity to a pyru... 272 5e-72
dbj|BAB10006.1| (AB006697) pyruvate kinase [Arabidopsis thaliana] 272 6e-72
sp|O62619|KPYK_DROME PYRUVATE KINASE (PK) >gi|3108349|gb|AAC1580... 272 8e-72
emb|CAA66194.1| (X97579) pyruvate kinase [Agaricus bisporus] 272 8e-72
emb|CAA62560.1| (X91106) pyruvate kinase [Agaricus bisporus] 272 8e-72
gb|AAG18902.1| (AE004992) pyruvate kinase; PykA [Halobacterium s... 272 8e-72
gb|AAC28104.1| (AF079586) pyruvate kinase; PK [Zymomonas mobilis] 271 1e-71
sp|P30615|KPY1_TRYBB PYRUVATE KINASE 1 (PK 1) >gi|102108|pir||S1... 271 1e-71
sp|P30616|KPY2_TRYBB PYRUVATE KINASE 2 (PK 2) >gi|102107|pir||S1... 271 1e-71
sp|P43924|KPYK_HAEIN PYRUVATE KINASE (PK) >gi|1075198|pir||C6413... 271 1e-71
gb|AAF55979.1| (AE003738) PyK gene product [Drosophila melanogas... 271 1e-71
sp|P57404|KPYK_BUCAI PYRUVATE KINASE (PK) >gi|10038993|dbj|BAB13... 271 1e-71
sp|O05118|KPYK_METEX PYRUVATE KINASE (PK) >gi|1907336|gb|AAB6649... 270 2e-71
dbj|BAB10440.1| (AB009055) pyruvate kinase [Arabidopsis thaliana] 270 2e-71
dbj|BAB11262.1| (AB009049) pyruvate kinase [Arabidopsis thaliana] 269 4e-71
sp|P32044|KPYK_THEAC PYRUVATE KINASE (PK) >gi|10640173|emb|CAC12... 269 4e-71
gi|6319279 Pyruvate kinase; Cdc19p [Saccharomyces cerevisiae] >g... 268 7e-71
sp|Q10208|KPYK_SCHPO PYRUVATE KINASE >gi|7493249|pir||T38890 pyr... 268 1e-70
pir||T45166 pyruvate kinase (EC 2.7.1.40) [imported] - fission y... 267 2e-70
gb|AAF05863.1|AC011698_14 (AC011698) putative pyruvate kinase [A... 266 3e-70
pir||F81684 pyruvate kinase TC0609 [imported] - Chlamydia murida... 266 4e-70
pir||JC2456 pyruvate kinase (EC 2.7.1.40) - Trypanoplasma borell... 265 6e-70
gb|AAF55980.2| (AE003738) CG7069 gene product [Drosophila melano... 265 1e-69
gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococc... 263 2e-69
pir||JC1267 pyruvate kinase (EC 2.7.1.40) - yeast (Yarrowia lipo... 262 5e-69
dbj|BAB01059.1| (AB023041) pyruvate kinase [Arabidopsis thaliana] 262 5e-69
emb|CAA24631.1| (V01321) pyruvate kinase [Saccharomyces cerevisiae] 262 7e-69
pir||E83104 pyruvate kinase II PA4329 [imported] - Pseudomonas a... 261 9e-69
dbj|BAA88185.1| (AP000836) ESTs AU081247(C50004),AU068940(C51113... 260 2e-68
sp|P94685|KPYK_CHLTR PYRUVATE KINASE (PK) >gi|7434455|pir||G7152... 259 4e-68
sp|Q42954|KPYC_TOBAC PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|5420... 258 1e-67
gi|6324923 pyruvate kinase; Pyk2p [Saccharomyces cerevisiae] >gi... 257 2e-67
sp|Q42806|KPYC_SOYBN PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|7434... 256 4e-67
dbj|BAA95686.1| (AB042618) pyruvate kinase [Hydrogenophilus ther... 254 1e-66
pir||T47704 pyruvate kinase-like protein - Arabidopsis thaliana ... 252 5e-66
pir||A82427 pyruvate kinase II VCA0708 [imported] - Vibrio chole... 252 5e-66
gb|AAB41226.1| (U83196) pyruvate kinase [Chlamydia trachomatis] 251 1e-65
sp|Q07637|KPYK_LACLA PYRUVATE KINASE >gi|421428|pir||B40620 pyru... 247 2e-64
gb|AAF44707.1| (AF242871) cytosolic pyruvate kinase [Lilium long... 244 2e-63
sp|P22200|KPYC_SOLTU PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|1004... 243 2e-63
pir||JC1481 pyruvate kinase (EC 2.7.1.40), cytosolic - potato 242 7e-63
sp|P31865|KPYK_TRIRE PYRUVATE KINASE >gi|484468|pir||JN0780 pyru... 241 1e-62
pir||A72119 pyruvate kinase CP0677 [imported] - Chlamydophila pn... 238 1e-61
sp|Q40545|KPYA_TOBAC PYRUVATE KINASE ISOZYME A, CHLOROPLAST PREC... 236 3e-61
pir||S51946 pyruvate kinase (EC 2.7.1.40) A, chloroplast - commo... 236 3e-61
dbj|BAA98307.1| (AP002545) pyruvate kinase [Chlamydophila pneumo... 236 5e-61
sp|P55964|KPYG_RICCO PYRUVATE KINASE ISOZYME G, CHLOROPLAST 235 7e-61
sp|Q43117|KPYA_RICCO PYRUVATE KINASE ISOZYME A, CHLOROPLAST PREC... 235 1e-60
gb|AAA27629.1| (M98350) pyruvate kinase-like protein [unidentifi... 234 2e-60
sp|P47458|KPYK_MYCGE PYRUVATE KINASE (PK) >gi|1361781|pir||H6422... 219 7e-56
pir||T47720 pyruvate kinase-like protein - Arabidopsis thaliana ... 218 1e-55
pir||T10054 pyruvate kinase (EC 2.7.1.40) isoform beta - castor ... 214 1e-54
sp|P78031|KPYK_MYCPN PYRUVATE KINASE (PK) >gi|2146579|pir||S7385... 212 1e-53
dbj|BAA15445.1| (D90810) Pyruvate kinase (EC 2.7.1.40) I [Escher... 210 4e-53
pir||T47556 pyruvate kinase-like protein - Arabidopsis thaliana ... 199 5e-50
gb|AAD24640.1|AC006919_20 (AC006919) putative pyruvate kinase [A... 178 2e-43
pir||B82923 pyruvate kinase UU186 [imported] - Ureaplasma urealy... 176 6e-43
sp|O30853|KPY1_PHOLE PYRUVATE KINASE I (PK-1) >gi|7434445|pir||P... 153 3e-36
gb|AAF19604.1|AF150875_1 (AF150875) pyruvate kinase [Giardia int... 146 6e-34
dbj|BAA16043.1| (D90853) Pyruvate kinase (EC 2.7.1.40) I [Escher... 118 1e-25
gb|AAB69999.1| (AF012877) pyruvate kinase [Spiroplasma citri] 87 3e-16
>pir||G75052 pyruvate kinase (EC 2.7.1.40) (pk) PAB1441 - Pyrococcus abyssi
(strain Orsay) >gi|5458829|emb|CAB50316.1| (AJ248287)
PYRUVATE KINASE (EC 2.7.1.40) (PK) [Pyrococcus abyssi]
Length = 478
Score = 930 bits (2377), Expect = 0.0
Identities = 478/478 (100%), Positives = 478/478 (100%)
Query: 1 MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI 60
MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI
Sbjct: 1 MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI 60
Query: 61 SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120
SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR
Sbjct: 61 SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120
Query: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM
Sbjct: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK
Sbjct: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV
Sbjct: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT
Sbjct: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM
Sbjct: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
Query: 421 FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA
Sbjct: 421 FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
>pir||F71171 probable pyruvate kinase - Pyrococcus horikoshii
>gi|3256976|dbj|BAA29659.1| (AP000002) 478aa long
hypothetical pyruvate kinase [Pyrococcus horikoshii]
Length = 478
Score = 807 bits (2061), Expect = 0.0
Identities = 402/478 (84%), Positives = 445/478 (92%)
Query: 1 MIAMRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI 60
M M+LP HKTKIVATIGPAT+S+ MIKKLIE G++V R+NFSHG+FEEHAK+IE VR+
Sbjct: 1 MRRMKLPSHKTKIVATIGPATNSKKMIKKLIEAGMNVARINFSHGTFEEHAKIIEMVREQ 60
Query: 61 SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120
SQKLDRRVAILADLPGLKIRVGEIKGGYVEL+RGEKV LTT+D+ GDETTIPVEYKDFP+
Sbjct: 61 SQKLDRRVAILADLPGLKIRVGEIKGGYVELERGEKVTLTTKDIEGDETTIPVEYKDFPK 120
Query: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
LVSKGDVIYLSDGYIVLRVE+V+ +VEAVV+SGGKLFSRKGINIPKAYLPVEA+TPRD+
Sbjct: 121 LVSKGDVIYLSDGYIVLRVEDVKENEVEAVVISGGKLFSRKGINIPKAYLPVEAITPRDI 180
Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
EI+KFAIE GVDAIGLSFVG+VYDVLK KSFLE+N A D FVI+KIERPDAVRNF+EIL
Sbjct: 181 EIMKFAIEHGVDAIGLSFVGNVYDVLKAKSFLERNGAGDTFVIAKIERPDAVRNFNEILN 240
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
A+DGIMIARGDLGVEMPIE+LPILQK LIRKAN EGKPVITATQMLVSMT EKVPTRAEV
Sbjct: 241 AADGIMIARGDLGVEMPIEQLPILQKRLIRKANMEGKPVITATQMLVSMTMEKVPTRAEV 300
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
TDVANAILDGTDAVMLSEETA+GKFPI+AV+MMA+IAKVTEEYRESFG++R+RE +E
Sbjct: 301 TDVANAILDGTDAVMLSEETAVGKFPIEAVEMMARIAKVTEEYRESFGITRMREFLEGTK 360
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
RGTIKEAI RSIIDA+CT+ IK+ILTPT+TGRTARLISRFKPKQWI FST E+VCNNLM
Sbjct: 361 RGTIKEAITRSIIDAICTIGIKFILTPTKTGRTARLISRFKPKQWILAFSTREKVCNNLM 420
Query: 421 FSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
FSYGVY FC+EEGF+E DI+RLIKGLGLV SDDIVLMTEGKPIEKT+GTNSIKIFQIA
Sbjct: 421 FSYGVYPFCMEEGFNENDIVRLIKGLGLVGSDDIVLMTEGKPIEKTVGTNSIKIFQIA 478
>dbj|BAB06882.1| (AP001517) pyruvate kinase [Bacillus halodurans]
Length = 584
Score = 374 bits (951), Expect = e-103
Identities = 204/472 (43%), Positives = 295/472 (62%), Gaps = 7/472 (1%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGPA+ S +++L+E G++V RLNFSHG FEEH I+ +R+ ++++ + VA
Sbjct: 3 KTKIVCTIGPASESVEKLEQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAKRIGKTVA 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL D G +IR ++GG ELK G+++V++ ++VVG I V Y V G I
Sbjct: 63 ILLDTKGPEIRTQTLEGGVAELKAGQELVISMKEVVGTSERISVTYPGLVHDVVPGAKIL 122
Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
L DG I L V EVR Q++ V++ G L ++KG+N+P + + +T +D IKF IEQ
Sbjct: 123 LDDGLIGLEVVEVRDQEILTKVLNSGTLKNKKGVNVPNVSVNLPGITEKDAADIKFGIEQ 182
Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
GVD I SFV DVL+++ LE++ AE + +I KIE + V N +EIL+ SDG+M+AR
Sbjct: 183 GVDFIAASFVRRAQDVLEIRELLEQHGAEHIKIIPKIENQEGVDNIEEILEVSDGLMVAR 242
Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
GDLGVE+P E +P++QK LI+K N KPVITATQML SM PTRAE +DVANAI D
Sbjct: 243 GDLGVEIPAEEVPLVQKSLIKKCNLVAKPVITATQMLDSMQRNPRPTRAEASDVANAIFD 302
Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
GTDA+MLS ETA G +P++AV+ M++IA E ++ + R TI AI+
Sbjct: 303 GTDAIMLSGETAAGDYPVEAVQTMSRIA---ERAEQALNYQEILSKHTKEARTTITSAIS 359
Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
+S+ LN ILT T +G TAR++++++PK I ++NE V L +GVY+
Sbjct: 360 QSVGHTAFNLNASAILTATESGHTARVVAKYRPKSPIVAVTSNETVVRQLALVWGVYSIL 419
Query: 430 LEEGFDERDIIRLIKGLG----LVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
EE D++++ LV+ D+V++T G P+ +T TN +K+ I
Sbjct: 420 GEEAETTDDMLQVTVETALKSQLVKQGDLVVITAGVPVGETGTTNIMKVHVI 471
>pir||B72406 pyruvate kinase - Thermotoga maritima (strain MSB8)
>gi|4980705|gb|AAD35300.1|AE001705_11 (AE001705)
pyruvate kinase [Thermotoga maritima]
Length = 466
Score = 357 bits (907), Expect = 1e-97
Identities = 204/471 (43%), Positives = 291/471 (61%), Gaps = 13/471 (2%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
TKIV T+GP T S MI+K+I+ GV+V R+N SHG + E + I K++D+ +K + VAI
Sbjct: 4 TKIVCTVGPRTDSYEMIEKMIDLGVNVFRINTSHGDWNEQEQKILKIKDLREKKKKPVAI 63
Query: 71 LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYL 130
L DL G KIR G ++ +VELK G+ LTT++++G+E + V P+ V KGD I L
Sbjct: 64 LIDLAGPKIRTGYLEKEFVELKEGQIFTLTTKEILGNEHIVSVNLSSLPKDVKKGDTILL 123
Query: 131 SDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQG 190
SDG IVL V E +V+ VV GGK+ R+G+N+P A L VE++T RD E IK
Sbjct: 124 SDGEIVLEVIETTDTEVKTVVKVGGKITHRRGVNVPTADLSVESITDRDREFIKLGTLHD 183
Query: 191 VDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARG 250
V+ LSFV DVLK K + K+ +++ VISKIE A+ +EI+K SDGIM+ARG
Sbjct: 184 VEFFALSFVRKPEDVLKAKEEIRKH-GKEIPVISKIETKKALERLEEIIKVSDGIMVARG 242
Query: 251 DLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDG 310
DLGVE+PIE +PI+QKE+I+ + KPVI ATQ+L SM PTRAEVTD+ANAI DG
Sbjct: 243 DLGVEIPIEEVPIVQKEIIKLSKYYSKPVIVATQILESMIENPFPTRAEVTDIANAIFDG 302
Query: 311 TDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIAR 370
DA++L+ ETA+GK P++A+K+++K+AK E+ E F +E T I EAI+
Sbjct: 303 ADALLLTAETAVGKHPLEAIKVLSKVAKEAEKKLEFF------RTIEYDT-SDISEAISH 355
Query: 371 SIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCL 430
+ +LN K I+TPT +G TA +S++ Q I + E+ L V
Sbjct: 356 ACWQLSESLNAKLIITPTISGSTAVRVSKYNVSQPIVALTPEEKTYYRLSLVRKVIPVLA 415
Query: 431 EEGFDERDII----RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
E+ E + I + ++ +GL E D+V++T G P K TN+I++ ++
Sbjct: 416 EKCSQELEFIEKGLKKVEEMGLAEKGDLVVLTSGVP-GKVGTTNTIRVLKV 465
>sp|P80885|KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE PROTEIN 17) (VEG17)
>gi|7434444|pir||G69685 pyruvate kinase (EC 2.7.1.40)
pykA - Bacillus subtilis >gi|2293265|gb|AAC00343.1|
(AF008220) pyruvate kinase [Bacillus subtilis]
>gi|2635383|emb|CAB14878.1| (Z99118) pyruvate kinase
[Bacillus subtilis]
Length = 585
Score = 357 bits (906), Expect = 2e-97
Identities = 200/477 (41%), Positives = 297/477 (61%), Gaps = 16/477 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGPA+ S M+ KL+E+G++V RLNFSHG FEEH I+ +R+ S+KL + V
Sbjct: 3 KTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHGARIKNIREASKKLGKNVG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL D G +IR ++ G +EL+ G++++++ +VVG I V Y+ V +G I
Sbjct: 63 ILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTDKISVTYEGLVHDVEQGSTIL 122
Query: 130 LSDGYIVLRVEEVRG--QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
L DG I L V +V ++++ V++ G L ++KG+N+P + + +T +D I F I
Sbjct: 123 LDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNVPGVSVNLPGITEKDARDIVFGI 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD I SF+ DVL+++ LE+++A+D+ +I KIE + V N D IL+ SDG+M+
Sbjct: 183 EQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGLMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E +P++QKELI+K N GKPVITATQML SM PTRAE +DVANAI
Sbjct: 243 ARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGTRGTI 364
DGTDA+MLS ETA G +P++AV+ M IA +EE Y+E R D TI
Sbjct: 303 FDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRR------DQVGMTI 356
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
+AI +S+ LN I+TPT +G TAR+I++++P+ I + N+ + L G
Sbjct: 357 TDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSG 416
Query: 425 VYAFCLE--EGFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
V+A + DE D ++ G+V+ D++++T G + ++ TN +K+ +
Sbjct: 417 VFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAG-TVGESGTTNLMKVHTV 472
>pir||S27330 pyruvate kinase (EC 2.7.1.40) isoform 1 - Bacillus
stearothermophilus >gi|47828|emb|CAA40994.1| (X57859)
pyruvate kinase [Bacillus stearothermophilus]
Length = 494
Score = 356 bits (905), Expect = 2e-97
Identities = 206/478 (43%), Positives = 298/478 (62%), Gaps = 15/478 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGPA+ S + + +L+E G++V RLNFSHG EEH + I +R+ +++ R VA
Sbjct: 4 KTKIVCTIGPASESVDKLVQLMEAGMNVARLNFSHGDHEEHGRRIANIREAAKRTGRTVA 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL D G +IR ++ G +ELK G K+V++ +V+G I V Y VS G I
Sbjct: 64 ILLDTKGPEIRTHNMENGAIELKEGSKLVISMSEVLGTPEKISVTYPSLIDDVSVGAKIL 123
Query: 130 LSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
L DG I L V V Q E V V++GG L ++KG+N+P + + +T +D I F I
Sbjct: 124 LDDGLISLEVNAVDKQAGEIVTTVLNGGVLKNKKGVNVPGVKVNLPGITEKDRADILFGI 183
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
QG+D I SFV DVL+++ LE +DA + +I+KIE + V N DEIL+A+DG+M+
Sbjct: 184 RQGIDFIAASFVRRASDVLEIRELLEAHDALHIQIIAKIENEEGVANIDEILEAADGLMV 243
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E +P++QK LI+K N GKPVITATQML SM PTRAE +DVANAI
Sbjct: 244 ARGDLGVEIPAEEVPLIQKLLIKKCNMLGKPVITATQMLDSMQRNPRPTRAEASDVANAI 303
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR---GTI 364
DGTDAVMLS ETA G++P++AVK M +IA TE+ E R+++ T+ TI
Sbjct: 304 FDGTDAVMLSGETAAGQYPVEAVKTMHQIALRTEQALEH------RDILSQRTKESQTTI 357
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
+AI +S+ L++ I+TPT +G+T +++++++PK I ++NE V L +G
Sbjct: 358 TDAIGQSVAHTALNLDVAAIVTPTVSGKTPQMVAKYRPKAPIIAVTSNEAVSRRLALVWG 417
Query: 425 VY---AFCLEEGFDERDI-IRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
VY A + + D+ + GLV+ D+V++T G P+ +T TN +K+ I+
Sbjct: 418 VYTKEAPHVNTTDEMLDVAVDAAVRSGLVKHGDLVVITAGVPVGETGSTNLMKVHVIS 475
>sp|Q02499|KPYK_BACST PYRUVATE KINASE (PK) >gi|421472|pir||S29783 pyruvate kinase (EC
2.7.1.40) isoform 2 - Bacillus stearothermophilus
>gi|285623|dbj|BAA02406.1| (D13095) pyruvate kinase
[Bacillus stearothermophilus]
Length = 587
Score = 356 bits (905), Expect = 2e-97
Identities = 206/478 (43%), Positives = 298/478 (62%), Gaps = 15/478 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGPA+ S + + +L+E G++V RLNFSHG EEH + I +R+ +++ R VA
Sbjct: 4 KTKIVCTIGPASESVDKLVQLMEAGMNVARLNFSHGDHEEHGRRIANIREAAKRTGRTVA 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL D G +IR ++ G +ELK G K+V++ +V+G I V Y VS G I
Sbjct: 64 ILLDTKGPEIRTHNMENGAIELKEGSKLVISMSEVLGTPEKISVTYPSLIDDVSVGAKIL 123
Query: 130 LSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
L DG I L V V Q E V V++GG L ++KG+N+P + + +T +D I F I
Sbjct: 124 LDDGLISLEVNAVDKQAGEIVTTVLNGGVLKNKKGVNVPGVKVNLPGITEKDRADILFGI 183
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
QG+D I SFV DVL+++ LE +DA + +I+KIE + V N DEIL+A+DG+M+
Sbjct: 184 RQGIDFIAASFVRRASDVLEIRELLEAHDALHIQIIAKIENEEGVANIDEILEAADGLMV 243
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E +P++QK LI+K N GKPVITATQML SM PTRAE +DVANAI
Sbjct: 244 ARGDLGVEIPAEEVPLIQKLLIKKCNMLGKPVITATQMLDSMQRNPRPTRAEASDVANAI 303
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR---GTI 364
DGTDAVMLS ETA G++P++AVK M +IA TE+ E R+++ T+ TI
Sbjct: 304 FDGTDAVMLSGETAAGQYPVEAVKTMHQIALRTEQALEH------RDILSQRTKESQTTI 357
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
+AI +S+ L++ I+TPT +G+T +++++++PK I ++NE V L +G
Sbjct: 358 TDAIGQSVAHTALNLDVAAIVTPTVSGKTPQMVAKYRPKAPIIAVTSNEAVSRRLALVWG 417
Query: 425 VY---AFCLEEGFDERDI-IRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
VY A + + D+ + GLV+ D+V++T G P+ +T TN +K+ I+
Sbjct: 418 VYTKEAPHVNTTDEMLDVAVDAAVRSGLVKHGDLVVITAGVPVGETGSTNLMKVHVIS 475
>sp|Q55863|KPY1_SYNY3 PYRUVATE KINASE 1 (PK 1) >gi|7434447|pir||S76677 pyruvate kinase
(EC 2.7.1.40) 1 - Synechocystis sp. (strain PCC 6803)
>gi|1208453|dbj|BAA10621.1| (D64004) pyruvate kinase
[Synechocystis sp.]
Length = 483
Score = 355 bits (902), Expect = 5e-97
Identities = 203/484 (41%), Positives = 313/484 (63%), Gaps = 20/484 (4%)
Query: 4 MRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK 63
MR H+TKIVATIGPA+SS +I+++++ G++V RLNFSHGS+E+HA ++ +R + Q+
Sbjct: 11 MRPLSHRTKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQE 70
Query: 64 LDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
+D + +L DL G KIR+G++ GG +L+ GEKV L ++ GD V D+P L +
Sbjct: 71 MDTPITLLQDLQGPKIRIGQLPGGEKQLREGEKVSLVPVEI-GDRHPGAVGI-DYPHLAT 128
Query: 124 K---GDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
+ G+ I L DG + ++V ++ +V VV+GG L SRKG+N+P L + ++T +D
Sbjct: 129 EAKVGERILLDDGLLEMKVVSIQDPEVICEVVTGGILKSRKGVNLPGLVLTLPSMTTKDK 188
Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
+ ++F + QG+D + LSFV D+ +K FL + D+ VI+KIE+P A+ N +EI+
Sbjct: 189 QDLEFGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIVA 248
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
S+GIM+ARGDLGVE+ E++P LQKE+IR+ N PVITATQML SM PTRAE
Sbjct: 249 VSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAEA 308
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRE-LVEDG 359
+DVANAILDGTDAVMLS E+A+G++P+ +V+M+ KIA+ TE G+ + +E+
Sbjct: 309 SDVANAILDGTDAVMLSGESAVGQYPVKSVQMLRKIAEETE-----VGLHLVNNPPIENT 363
Query: 360 TRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
+ EA+ +ID + L++KYI+T T +G T+ L S +P + F+ +E+V ++L
Sbjct: 364 ETHALSEALV--VIDGI--LDLKYIVTFTTSGFTSLLASNQRPSVPVIAFTPSEKVYHSL 419
Query: 420 MFSYGVYAFCLEEGFDE-RDIIR----LIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
+G+ F + E FD D+I+ L++ +VE D +L+ G P + GTN +KI
Sbjct: 420 NLVWGIIPFLINEEFDTFEDLIQQAEVLLRDRKMVEKGDQLLIMAGIPTKIPRGTNFLKI 479
Query: 475 FQIA 478
+I+
Sbjct: 480 HRIS 483
>gb|AAC12962.1| (U73943) pyruvate kinase I [Bacillus subtilis]
Length = 584
Score = 353 bits (896), Expect = 3e-96
Identities = 200/477 (41%), Positives = 294/477 (60%), Gaps = 17/477 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGPA+ S M+ KL+E+G++V RLNFSHG F+EH I+ +R+ ++KL + V
Sbjct: 3 KTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFQEHGARIKNIREAAEKLGKNVG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL D G +IR ++ G +EL G K+V++ +V+G I V Y+ V+KG I
Sbjct: 63 ILLDTKGPEIRTHTMENGSIELNAGSKLVISMTEVIGTPDKISVTYEGLVHDVNKGSTIL 122
Query: 130 LSDGYIVLRVEEVRG--QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
L DG I L V +V ++++ V++ G L ++KG+N+P +T +D I F I
Sbjct: 123 LDDGLIGLEVLDVDAVKREIKTKVLNNGTLKNKKGVNVPGRKCQSSGITEKDARDIVFGI 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD I SF+ DVL+++ LE+++A+D+ +I KIE + V N D IL+ SDG+M+
Sbjct: 183 EQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGLMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E +P++QKELI+K N GKPVITATQML SM PTRAE +DVANAI
Sbjct: 243 ARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGTRGTI 364
DGTDA+MLS ETA G +P++AV+ M IA +EE Y+E R D TI
Sbjct: 303 FDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRR------DQVGMTI 356
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
+AI +S+ LN I+TPT +G TAR+I++++P+ I + N+ + L G
Sbjct: 357 TDAIGQSVAHTAINLNAA-IVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSG 415
Query: 425 VYAFCLE--EGFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
V+A + DE D ++ G+V+ D++++T G + ++ TN +K+ +
Sbjct: 416 VFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAG-TVGESGTTNLMKVHTV 471
>sp|P51181|KPYK_BACLI PYRUVATE KINASE (PK) >gi|1361386|pir||JC4220 pyruvate kinase (EC
2.7.1.40) [validated] - Bacillus licheniformis
>gi|1041099|dbj|BAA06727.1| (D31955) Pyruvate Kinase
[Bacillus licheniformis]
Length = 585
Score = 344 bits (872), Expect = 2e-93
Identities = 192/474 (40%), Positives = 288/474 (60%), Gaps = 10/474 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGPA+ S + +L+E G++V RLNFSHG FEEH I+ +R+ + KL + +
Sbjct: 3 KTKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAGKLGKDIG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL D G +IR ++ G +EL G +++++ +V+G I V Y VS G I
Sbjct: 63 ILLDTKGPEIRTHTMENGSIELAAGSQLIVSMDEVIGTPDKISVTYDGLIHDVSVGSTIL 122
Query: 130 LSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
L DG + L V ++ E V V++ G L ++KG+N+P + + +T +D I F I
Sbjct: 123 LDDGLVGLEVTDINKDKREIVTKVMNSGTLKNKKGVNVPGVSVNLPGITEKDANDIVFGI 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD I SFV DVL+++ LE+++A D+ +I KIE + V N D IL+ SDG+M+
Sbjct: 183 EQGVDFIAASFVRRPSDVLEIRELLEEHNAADIQIIPKIENQEGVDNIDAILEVSDGLMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E +P++QKELI+K N GKPVITATQML SM PTRAE +DVANAI
Sbjct: 243 ARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
DGTDA+MLS ETA G +P++AV+ M IA +E E+ ++ +I +A
Sbjct: 303 FDGTDAIMLSGETAAGNYPVEAVQTMHNIASRSE---EALNHKKILSARSKQVSMSITDA 359
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
I +S+ L++ I+TPT +G TAR+IS+++P+ I + N+ V L +GV+A
Sbjct: 360 IGQSVAHTAINLDVNAIVTPTESGHTARMISKYRPQAPIVAVTVNDAVSRKLSLVFGVFA 419
Query: 428 FCLEEGFDERDIIR--LIKGL--GLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
+ +++ + K L G+V D++++T G + + TN +K++ +
Sbjct: 420 TSGQNHSSTDEMLEKAVQKSLDTGIVRHGDLIVITAG-AVGEAGTTNLMKVYVV 472
>dbj|BAA89788.1| (AB037182) pyruvate kinase [Selenomonas ruminantium]
Length = 470
Score = 335 bits (849), Expect = 8e-91
Identities = 186/462 (40%), Positives = 281/462 (60%), Gaps = 14/462 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T GP+T +I LI NG++ R NFSHG EEH I VR+ ++K + ++
Sbjct: 4 KTKIVCTQGPSTEKPGVIDALIANGMNCARFNFSHGDHEEHLGRINMVREAAKKAGKVIS 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
++ D G ++R+GE K G V L++G K LT D GDET + V +K V GD +
Sbjct: 64 LILDTKGPEMRLGEFKDGKVMLEKGNKFTLTYDDEPGDETHVSVNHKGLYTEVKPGDTLL 123
Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
LSDG + L+V+E++G+D+ + + GK+ +RK + P L + ++ +D + I F EQ
Sbjct: 124 LSDGLVALKVDEIKGKDIVTTIQNSGKMSTRKRVAAPGVPLGLPPISEQDAKDIIFGCEQ 183
Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
+D + SF+ DV+ ++ +E+++ + ++ KIE + V+NFD IL+ SDGIM+AR
Sbjct: 184 DMDFVAASFIQRPDDVIAIRKLIEEHNGH-MEILPKIENLEGVKNFDAILEVSDGIMVAR 242
Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
GDLGVE+P E +P++QKE+IRK N GKPVI ATQML SM PTRAEV+DV NAILD
Sbjct: 243 GDLGVEVPAEDVPLIQKEIIRKCNAAGKPVIVATQMLDSMERNPRPTRAEVSDVGNAILD 302
Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTRGTIKE 366
GTDA+MLS ETA G +P++AV M +IA+ E EY+E + + R + +E TR
Sbjct: 303 GTDAIMLSGETASGDYPVEAVATMNRIAQRMESSLEYKELY-VERGLQHMESRTR----- 356
Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
AIA + + L+ I+TPT +G T +++S+++PK I ++ +E+V L +GVY
Sbjct: 357 AIAHATVQMAYELDAPAIITPTESGYTTKVVSKYRPKAAIVAYTPSEKVLRQLNLRWGVY 416
Query: 427 AFCLEEGFDERDIIRLIKGLG----LVESDDIVLMTEGKPIE 464
+ D ++I LV+ D+ ++T G +E
Sbjct: 417 PVLGTQWSDVDEMISNATAAAVKEDLVQRGDLTIITSGVKME 458
>sp|P51182|KPYK_BACPY PYRUVATE KINASE (PK) >gi|1363364|pir||JC4219 pyruvate kinase (EC
2.7.1.40) - Bacillus psychrophilus
>gi|1041097|dbj|BAA06725.1| (D31954) Pyruvate Kinase
[Bacillus psychrophilus]
Length = 586
Score = 332 bits (842), Expect = 6e-90
Identities = 193/480 (40%), Positives = 285/480 (59%), Gaps = 21/480 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGPA+ S ++++LIE G++V RLNFSHG+ EH I+ +R ++++ + V
Sbjct: 3 KTKIVCTIGPASESPELLEQLIEAGMNVARLNFSHGNHAEHKARIDSIRKVAREKGKVVG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL D G +IR + G +EL G+K+ ++ V G+ V Y V++G VI
Sbjct: 63 ILLDTKGPEIRTHSMMNGKLELVTGQKIDISMTQVEGNNDVFSVSYDKLIEDVNEGSVIL 122
Query: 130 LSDGYIVLRVEEVRGQDV-----EAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK 184
L DG I L EV G+DV ++++ G L + KG+NIP + + +T +D E I
Sbjct: 123 LDDGLIQL---EVTGKDVARGLIHTLIINSGSLSNNKGVNIPGVSVQLPGMTEKDAEDIL 179
Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
F I +GVD I SFV DV+++++ LE N+ ++ +I KIE + V N DEIL SDG
Sbjct: 180 FGIREGVDFIAASFVRRASDVMEIRALLENNNGSNLQIIPKIENQEGVDNIDEILNVSDG 239
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
+M+ARGDLGVE+P E +P++QK LI K N GKPVITATQML SM PTRAE +DVA
Sbjct: 240 LMVARGDLGVEIPPEEVPLVQKNLIEKCNQAGKPVITATQMLDSMQRNPRPTRAEASDVA 299
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTR 361
NAI DGTDA+MLS ETA G +P+++V+ M +IA TE +YR S +R RE
Sbjct: 300 NAIFDGTDAIMLSGETAAGIYPVESVQTMDRIALTTEAAIDYR-SVVSTRRRE-----KH 353
Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMF 421
G + EAI ++ L +K +L PT +G TA++I++++P + +++E L
Sbjct: 354 GNMTEAIGQAAAYTAINLKVKAVLAPTESGHTAKMIAKYRPGCPVIAVTSSEMCSRKLSL 413
Query: 422 SYGVYAFCLEEGFDERDIIRLIKGLGL----VESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
+GVY ++ +I++ + V D+V++T G P+ + TN +KI I
Sbjct: 414 IWGVYPIVGKKASSIDEILQESVEESVKHQYVGHGDVVIITAGVPVGEAGTTNLMKIHVI 473
>pir||B75251 pyruvate kinase - Deinococcus radiodurans (strain R1)
>gi|6460464|gb|AAF12171.1|AE002092_9 (AE002092) pyruvate
kinase [Deinococcus radiodurans]
Length = 482
Score = 332 bits (842), Expect = 6e-90
Identities = 196/471 (41%), Positives = 286/471 (60%), Gaps = 9/471 (1%)
Query: 8 DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
D TKIVAT+GPA+ S ++ ++I+ G++VVRLNFSHG E+H + ++ VRD++
Sbjct: 5 DRATKIVATVGPASRSTEVLGRMIDVGLNVVRLNFSHGDLEDHRQTVQMVRDLAVSKGVT 64
Query: 68 VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
+ IL DL G KIRVG G V L G+K V+T +V G+ + YK V+ G
Sbjct: 65 IGILQDLQGPKIRVGRFAEGSVTLNPGQKFVITMDEVEGNAERVGSTYKGLAGDVTPGMT 124
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG + LRV+ VRG D++ V+ GG L + KGIN+P+A L V A++ +D++ ++F
Sbjct: 125 LLLDDGNMSLRVDHVRGNDIQTTVLIGGTLKNNKGINVPEADLTVPALSEKDVQDMEFGA 184
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
GVD + LSFV S D+L + +L + + +++KIE+P AV F +ILK DG+M+
Sbjct: 185 SLGVDWVALSFVRSRDDLLLARHYLARFGSR-AKLMAKIEKPQAVDRFADILKEVDGVMV 243
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVEM E++P +QK +IR GKPVITATQML SM PTRAE +DVANAI
Sbjct: 244 ARGDLGVEMRPEQVPTIQKRIIRMCREAGKPVITATQMLESMINLPRPTRAEASDVANAI 303
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
DGTDAVMLS E+A G++P+++V MM +IA+ E E + + + R++V D + ++A
Sbjct: 304 YDGTDAVMLSAESAAGQYPVESVAMMDRIAREAEA-SELYQLMQ-RQVVMDTEQA--QDA 359
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
IA + + L I+T T TG A IS+ +P I + NE N L S+GVY
Sbjct: 360 IALAACNIGAKLEAPAIVTFTSTGGAATRISKNRPPLAIVALTPNEITRNQLALSWGVYP 419
Query: 428 FCLEEGFDERDIIRL----IKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
E+ D D++R+ +K GL + D ++T G P TN +++
Sbjct: 420 MLSEDPEDTDDMVRIANDELKKSGLADVGDRYVITAGVPFGVRGTTNMLRV 470
>emb|CAB70653.1| (AL137242) pyruvate kinase [Streptomyces coelicolor A3(2)]
Length = 476
Score = 332 bits (842), Expect = 6e-90
Identities = 186/472 (39%), Positives = 280/472 (58%), Gaps = 8/472 (1%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
++KIV T+GPA S + LIE G++V R NFSHG+ EH ++VR +++ R +
Sbjct: 3 RSKIVCTLGPAVDSHEQLVTLIEAGMNVARFNFSHGTHAEHQGRYDRVRAAAKETGRAIG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
+LADL G KIR+ G VEL RG++ +T DV GD T YK P V+KGD +
Sbjct: 63 VLADLQGPKIRLETFAEGPVELVRGDEFTITAEDVPGDRTICGTTYKGLPGDVTKGDQVL 122
Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
++DG + L+V EV G V+ +V+ GG + KGIN+P A + V A++ +D+E ++FA+
Sbjct: 123 INDGNVELKVTEVEGPRVKTIVIEGGVISDHKGINLPGAAVNVPALSEKDVEDLRFALRM 182
Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
G D + LSFV DV V +++ + V VI+K+E+P AV N ++++ A DG+M+AR
Sbjct: 183 GCDLVALSFVRDAKDVADVHRVMDE-EGRRVPVIAKVEKPQAVDNMEDVVMAFDGVMVAR 241
Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
GDL VE P+E++P++QK LI KPVI ATQM+ SM PTRAE +DVANAILD
Sbjct: 242 GDLAVEYPLEKVPMVQKRLIELCRRNAKPVIVATQMMESMITNSRPTRAEASDVANAILD 301
Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
G DAVMLS E+++G +PI+ VK M+KI E+ S G+ L + T+G ++A
Sbjct: 302 GADAVMLSAESSVGAYPIETVKTMSKIVTAAEQELLSKGLQPLVPGKKPRTQG---GSVA 358
Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
R+ + L K ++ T++G TAR +SR++ Q I F+T+E N L S+GV
Sbjct: 359 RAAAEIADFLGGKGLVAFTQSGDTARRLSRYRAAQPILAFTTDESTRNQLALSWGVEPHV 418
Query: 430 LEEGFDERDIIRLI----KGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
+ +++ L+ LG D V++T G P + TN +++ +
Sbjct: 419 VPFVNTTDEMVDLVDQETARLGRFSDGDTVVITAGSPPGVSGTTNMVRVLHL 470
>sp|P14178|KPY1_ECOLI PYRUVATE KINASE I (PK-1) >gi|7428041|pir||D64925 pyruvate kinase
(EC 2.7.1.40) [validated] - Escherichia coli
>gi|1549287|gb|AAB47952.1| (U68703) pyruvate kinase
[Escherichia coli] >gi|1787965|gb|AAC74746.1| (AE000262)
pyruvate kinase I (formerly F), fructose stimulated
[Escherichia coli K12]
Length = 470
Score = 328 bits (832), Expect = 8e-89
Identities = 187/472 (39%), Positives = 277/472 (58%), Gaps = 12/472 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S M+ K+++ G++V+RLNFSHG + EH + I+ +R++ K + A
Sbjct: 3 KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++GG V LK G+ TT + V+G+ + V Y+ F +S G+
Sbjct: 63 ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG I + V + G V V++ G L KG+N+P + + A+ +D + + F
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV++++ L+ + E++ +ISKIE + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E + QK +I K K VITATQML SM PTRAE DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDGTDAVMLS E+A GK+P++AV +MA I + T+ M+ E D + I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ R ++ L+ I+ T+ G++AR + ++ P I +TNE+ + L+ S GV
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417
Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
++E D RL K L GL D+V+M G + T T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469
>sp|Q56301|KPYK_THELI PYRUVATE KINASE (PK) >gi|2147994|pir||A57418 pyruvate kinase -
Thermococcus litoralis (fragment)
>gi|1016357|emb|CAA58793.1| (X83963) pyruvate kinase
[Thermococcus litoralis]
Length = 220
Score = 327 bits (829), Expect = 2e-88
Identities = 160/215 (74%), Positives = 187/215 (86%)
Query: 4 MRLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK 63
M LP HKTKI+ATIGPA+ + IKK+I+ G+SV R+NFSHG+ EEHAK IE VRD+++K
Sbjct: 5 MELPSHKTKIIATIGPASKQKESIKKMIKAGMSVARINFSHGTLEEHAKTIETVRDVAEK 64
Query: 64 LDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
L+RRVAIL DLPGLK+RVG+IKG V L++G+KVVLTTRD+ GDETTIPVE+KD P+LVS
Sbjct: 65 LERRVAILGDLPGLKMRVGKIKGDSVTLRKGDKVVLTTRDIEGDETTIPVEFKDLPKLVS 124
Query: 124 KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
KGD IYLSDGYI+LRVEEVR +VE VVV+GG LFS KGINIPKA LP+EA+TPRD EII
Sbjct: 125 KGDTIYLSDGYIMLRVEEVRENEVECVVVNGGILFSHKGINIPKANLPIEAITPRDFEII 184
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE 218
+FAIE GVDAIGLSFVGSVYDVLKVKSFLEK A+
Sbjct: 185 EFAIEHGVDAIGLSFVGSVYDVLKVKSFLEKKSAD 219
>sp|P73534|KPY2_SYNY3 PYRUVATE KINASE 2 (PK 2) >gi|7434448|pir||S77240 pyruvate kinase
(EC 2.7.1.40) 2 - Synechocystis sp. (strain PCC 6803)
>gi|1652654|dbj|BAA17574.1| (D90907) pyruvate kinase
[Synechocystis sp.]
Length = 591
Score = 326 bits (828), Expect = 2e-88
Identities = 192/420 (45%), Positives = 266/420 (62%), Gaps = 12/420 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKIVATIGPAT S+ ++++LI+ G + RLNFSHG H + I +R I+ +L++ V
Sbjct: 9 RTKIVATIGPATQSKEVLRQLIQAGATTFRLNFSHGDHAYHQQSIRLIRQIAFELNQPVG 68
Query: 70 ILADLPGLKIRVGEI--KGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
IL DL G KIRVG+ G V+LK G+ LT+R V ET + Y+ V G
Sbjct: 69 ILQDLQGPKIRVGKFLNDAGSVQLKNGDPYTLTSRPVECTETISSISYEYLADEVPSGAR 128
Query: 128 IYLSDGYIVLRVEEVR--GQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
I L DG + + VEEV +D+ V+ GG L S KG+N P L V+A+T +D E + F
Sbjct: 129 ILLDDGKLEMLVEEVDTVARDLHCRVIVGGTLSSNKGVNFPGVCLSVKAMTDKDKEDLMF 188
Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGI 245
++QGVD + LSFV + D+ ++K + + V VI+KIE+ +A+++ +L+ DG+
Sbjct: 189 GLDQGVDWVALSFVRNPQDIDEIKGLIAAA-GKSVPVIAKIEKHEAIKDMQAVLEKCDGV 247
Query: 246 MIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVAN 305
M+ARGDLGVE+P E +PILQK+LI AN G PVITATQML SM PTRAEV+DVAN
Sbjct: 248 MVARGDLGVELPAEDVPILQKKLIATANRLGIPVITATQMLDSMVNSPRPTRAEVSDVAN 307
Query: 306 AILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIK 365
AILDGTDAVMLS ETAIGKFP++AV +MAKIA+ E+ E S+ + +R +I
Sbjct: 308 AILDGTDAVMLSNETAIGKFPVEAVAIMAKIAERIEQ--EDINPSQ-----AEASRTSIP 360
Query: 366 EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV 425
AI+ ++ TLN I++ T+TG TAR +S+F+PK I + + V L +GV
Sbjct: 361 NAISSAVSQIAETLNAAAIMSLTKTGSTARHVSKFRPKTPILAVTPHVDVSRQLQLVWGV 420
>pdb|1PKY|A Chain A, Pyruvate Kinase From E. Coli In The T-State
>gi|1310979|pdb|1PKY|B Chain B, Pyruvate Kinase From E.
Coli In The T-State >gi|1310981|pdb|1PKY|D Chain D,
Pyruvate Kinase From E. Coli In The T-State
>gi|1310980|pdb|1PKY|C Chain C, Pyruvate Kinase From E.
Coli In The T-State
Length = 470
Score = 326 bits (827), Expect = 3e-88
Identities = 186/472 (39%), Positives = 276/472 (58%), Gaps = 12/472 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S M+ K+++ G++V+RLNFSHG + EH + I+ +R++ K + A
Sbjct: 3 KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++GG V LK G+ TT + V+G+ + V Y+ F +S G+
Sbjct: 63 ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG I + V + G V V++ G L KG+N+P + + A+ +D + + F
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV++++ L+ + E++ +ISKIE + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E + QK +I K K VITAT ML SM PTRAE DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTRAEAGDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDGTDAVMLS E+A GK+P++AV +MA I + T+ M+ E D + I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ R ++ L+ I+ T+ G++AR + ++ P I +TNE+ + L+ S GV
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417
Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
++E D RL K L GL D+V+M G + T T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469
>pdb|1E0U|A Chain A, Structure R271l Mutant Of E. Coli Pyruvate Kinase
>gi|9955372|pdb|1E0U|B Chain B, Structure R271l Mutant
Of E. Coli Pyruvate Kinase >gi|9955373|pdb|1E0U|C Chain
C, Structure R271l Mutant Of E. Coli Pyruvate Kinase
>gi|9955374|pdb|1E0U|D Chain D, Structure R271l Mutant
Of E. Coli Pyruvate Kinase
Length = 470
Score = 325 bits (825), Expect = 5e-88
Identities = 186/472 (39%), Positives = 276/472 (58%), Gaps = 12/472 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S M+ K+++ G++V+RLNFSHG + EH + I+ +R++ K + A
Sbjct: 3 KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++GG V LK G+ TT + V+G+ + V Y+ F +S G+
Sbjct: 63 ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG I + V + G V V++ G L KG+N+P + + A+ +D + + F
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV++++ L+ + E++ +ISKIE + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E + QK +I K K VITAT ML SM PTRAE DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRALKVVITATMMLDSMIKNPRPTRAEAGDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDGTDAVMLS E+A GK+P++AV +MA I + T+ M+ E D + I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ R ++ L+ I+ T+ G++AR + ++ P I +TNE+ + L+ S GV
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417
Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
++E D RL K L GL D+V+M G + T T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469
>pdb|1E0T|A Chain A, R292d Mutant Of E. Coli Pyruvate Kinase
>gi|9955368|pdb|1E0T|B Chain B, R292d Mutant Of E. Coli
Pyruvate Kinase >gi|9955369|pdb|1E0T|C Chain C, R292d
Mutant Of E. Coli Pyruvate Kinase >gi|9955370|pdb|1E0T|D
Chain D, R292d Mutant Of E. Coli Pyruvate Kinase
Length = 470
Score = 323 bits (820), Expect = 2e-87
Identities = 185/472 (39%), Positives = 275/472 (58%), Gaps = 12/472 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S M+ K+++ G++V+RLNFSHG + EH + I+ +R++ K + A
Sbjct: 3 KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++GG V LK G+ TT + V+G+ + V Y+ F +S G+
Sbjct: 63 ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG I + V + G V V++ G L KG+N+P + + A+ +D + + F
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV++++ L+ + E++ +ISKIE + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E + QK +I K K VITAT ML SM PT AE DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTDAEAGDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDGTDAVMLS E+A GK+P++AV +MA I + T+ M+ E D + I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ R ++ L+ I+ T+ G++AR + ++ P I +TNE+ + L+ S GV
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417
Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
++E D RL K L GL D+V+M G + T T S+ +
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHV 469
>pir||S29004 pyruvate kinase (EC 2.7.1.40) I - Escherichia coli
>gi|147276|gb|AAA24392.1| (M24636) pyruvate kinase I (EC
2.7.1.40) [Escherichia coli]
Length = 462
Score = 323 bits (819), Expect = 3e-87
Identities = 182/453 (40%), Positives = 269/453 (59%), Gaps = 11/453 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S M+ K+++ G++V+RLNFSHG + EH + I+ +R++ K + A
Sbjct: 3 KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++GG V LK G+ TT + V+G+ + V Y+ F +S G+
Sbjct: 63 ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG I + V + G V V++ G L KG+N+P + + A+ +D + + F
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV++++ L+ + E++ +ISKIE + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E + QK +I K K VITATQML SM PTRAE DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDGTDAVMLS E+A GK+P++AV +MA I + T+ M+ E D + I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLEFNNDNRKLRITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ R ++ L+ I+ T+ G++AR + ++ P I +TNE+ + L+ S GV
Sbjct: 358 VCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVP 417
Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVL 456
++E D RL K L GL D+V+
Sbjct: 418 QLVKEITSTDDFYRLGKELALQSGLAHKGDVVV 450
>sp|P77983|KPY1_SALTY PYRUVATE KINASE I (PK-1) >gi|1526982|emb|CAA68205.1| (X99945)
pyruvate kinase like protein [Salmonella typhimurium]
Length = 470
Score = 323 bits (818), Expect = 4e-87
Identities = 185/472 (39%), Positives = 276/472 (58%), Gaps = 12/472 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S M+ K+++ G++V+RLNFSHG + EH + I+ +R++ K ++ A
Sbjct: 3 KTKIVCTIGPKTESEEMLSKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKKAA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++GG V LK G+ TT + VVG+ + V Y+ F +S G+
Sbjct: 63 ILLDTKGPEIRTIKLEGGNDVSLKAGQTFTFTTDKSVVGNNEIVAVTYEGFTSDLSVGNT 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG I + V + G V++ G L KG+N+P + + A+ +D + + F
Sbjct: 123 VLVDDGLIGMEVTAIEGNKCICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV++++ L+ + E++ +ISKIE + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVVEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E + QK +I K K VITATQML SM PTRAE DVANAI
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDGTDAVMLS E+A GK+P++AV +MA I + T+ M+ + D + I EA
Sbjct: 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV-----MNSRLDYNNDSRKLRITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ R ++ L I+ T+ G++AR + ++ P I +TNE L+ S GV +
Sbjct: 358 VCRGAVETAEKLEAPLIVVATQGGKSARAVRKYFPDATILALTTNEVTARQLVLSKGVVS 417
Query: 428 FCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
++E D RL K + GL + D+V+M G + T T S+ +
Sbjct: 418 QLVKEINSTDDFYRLGKDVALQSGLAQKGDVVVMVSGALVPSGTTNTASVHV 469
>dbj|BAA89378.1| (AB025342) ORF4 [Moritella marina]
Length = 470
Score = 318 bits (807), Expect = 7e-86
Identities = 186/475 (39%), Positives = 277/475 (58%), Gaps = 14/475 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S + +L+ G++V+RLNFSHG+F EH+ I+ +R +S+ L++++A
Sbjct: 3 KTKIVCTIGPKTESVEKLTELVNAGMNVMRLNFSHGNFAEHSVRIQNIRQVSENLNKKIA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
+L D G +IR +++ G V L G+ TT +VVG++ + V Y F + ++ G +
Sbjct: 63 VLLDTKGPEIRTIKLENGDDVMLTAGQSFTFTTDINVVGNKDCVAVTYAGFAKDLNPGAI 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
I + DG I + V +V+ V++ G L KG+N+P + + A++ +D + F
Sbjct: 123 ILVDDGLIEMEVVATTDTEVKCTVLNTGALGENKGVNLPNISVGLPALSEKDKADLAFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQ VD + SF+ DV +++ L N E++ +ISKIE + V NFDEIL SDGIM+
Sbjct: 183 EQEVDFVAASFIRKADDVREIREILFNNGGENIQIISKIENQEGVDNFDEILAESDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E + + QK +I+K N GK VITATQML SM + PTRAE DVANA+
Sbjct: 243 ARGDLGVEIPVEEVIMAQKMMIKKCNKAGKVVITATQMLDSMISNPRPTRAEAGDVANAV 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDGTDAVMLS ETA GK+P++AV +MA I + T+ S +V R I EA
Sbjct: 303 LDGTDAVMLSGETAKGKYPVEAVSIMANICERTD---NSMSSDLGANIVAKSMR--ITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ + ++ L I+ TR G++A+ + ++ PK I +TNE+ L + GV +
Sbjct: 358 VCKGAVETTEKLCAPLIVVATRGGKSAKSVRKYFPKANILAITTNEKAAQQLCLTKGV-S 416
Query: 428 FCLEEGFDERDII-----RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
C+ E D D L GL + DIV+M G + TN+ + Q+
Sbjct: 417 SCIVEQIDSTDEFYRKGKELALATGLAKEGDIVVMVSGALVPSGT-TNTASVHQL 470
>pir||F81382 pyruvate kinase (EC 2.7.1.40) Cj0392c [imported] - Campylobacter
jejuni (strain NCTC 11168) >gi|6967866|emb|CAB74228.1|
(AL139075) pyruvate kinase [Campylobacter jejuni]
Length = 480
Score = 314 bits (797), Expect = 1e-84
Identities = 182/475 (38%), Positives = 284/475 (59%), Gaps = 19/475 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIVAT+GPA+ +++++I NGV+V RLNFSHG+ E H K ++ +R ++++L R+
Sbjct: 4 KTKIVATVGPASEKEEILRQMIINGVNVFRLNFSHGTHEYHKKNLDTIRRVAKELHTRIG 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT-----IPVEYKDFPRLVSK 124
IL D+ G KIR GE+K + ELK+G+++ ++G++ I + K ++
Sbjct: 64 ILQDISGPKIRTGELKEPF-ELKKGDRLDFYRETILGEKIAQNHYKISINQKSILDMLKI 122
Query: 125 GDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK 184
+ IYL DG I +V + Q +E ++ + G L S KGIN P + ++ +T +D +
Sbjct: 123 DEYIYLYDGSIRAKVVNIDNQKIETIIENDGFLNSNKGINFPNTKINIDVITQKDKNDLL 182
Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
+ I+ VD + +SFV + +D+ +V+ L +N+A+ + + +KIE+ DAV N DEI+K+SDG
Sbjct: 183 WGIKNEVDFLAISFVQNAHDIDEVREILAQNNAK-ISIFAKIEKFDAVENIDEIIKSSDG 241
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
IM+ARGDLG+E+P ++P +QKE+I+KAN KPVITATQML S+ K TRAE++DVA
Sbjct: 242 IMVARGDLGIEVPYYKVPNIQKEIIQKANNASKPVITATQMLFSLAKSKTATRAEISDVA 301
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
NA+LDGTDAVMLSEE+A+G P +AV +M + TE+ + +L D T
Sbjct: 302 NAVLDGTDAVMLSEESAVGIDPANAVDIMCQTIIETEKRYPYNKFNDFNDL--DNT---- 355
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
+ I RS LN I + T +G++A I+R++P I +E+ N+L +G
Sbjct: 356 -DKIMRSSAHLATDLNADAIFSLTSSGKSAIKIARYRPNIEIIAVGHSEKTLNSLSIVWG 414
Query: 425 VYAFCLEEGFDE-----RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
V L +E +D +R G ++ D L+T G P +N I+I
Sbjct: 415 VNPAILVNKSNELTELLKDSVRSSVEKGFMDEDKCYLLTAGFPTGVEGTSNLIRI 469
>pir||T35759 pyruvate kinase - Streptomyces coelicolor
>gi|5689907|emb|CAB52070.1| (AL109732) pyruvate kinase
[Streptomyces coelicolor A3(2)]
Length = 478
Score = 310 bits (785), Expect = 3e-83
Identities = 181/474 (38%), Positives = 272/474 (57%), Gaps = 11/474 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+ KIV T+GPAT S + IK L++ G+ + R NFSHG+ EH + +VR S + R V
Sbjct: 3 RAKIVCTLGPATDSYDQIKDLVDAGMDIARFNFSHGTHAEHEERYHRVRKASDETGRSVG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRD-VVGDETTIPVEYKDFPRLVSKGDVI 128
LADL G KIR+G G V L+RG+ +T + V GD Y V+ G+ +
Sbjct: 63 ALADLQGPKIRLGHFGEGPVLLERGDSFTITVEEGVEGDRYICGTTYAGLAEDVTPGERV 122
Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
+ DG + L V V G V V+ GG + KG+N+P + V A++ +D + +++A+
Sbjct: 123 LVDDGKVCLEVTGVDGTRVRTRVIEGGMVSDHKGLNLPGVAVSVPALSKKDEDDLRWALR 182
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
G D + LSFV S D+L V +++ + + VI+K+E+P AV N ++I+ A DGIM+A
Sbjct: 183 AGFDVVALSFVRSGRDILDVHRIMDE-EGRRLPVIAKVEKPQAVENIEDIVAAFDGIMVA 241
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLGVEMP+E++P +QK ++ A KPVI ATQML SM PTRAE +DVANA++
Sbjct: 242 RGDLGVEMPLEQVPTVQKRAVKLAKRNAKPVIVATQMLDSMIDNARPTRAEASDVANAVI 301
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
DGTDAVMLS ET++GK P D V+ MA+I + EE + G+ L E + T+G A+
Sbjct: 302 DGTDAVMLSGETSVGKHPTDTVRTMARIVEAAEEDILAKGLPPLTERNKPRTQG---GAV 358
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
AR+ + L K+++ T++G T R +SR++ + F+ + L ++GV F
Sbjct: 359 ARAAAEMGDFLGAKFLVAFTQSGDTVRRLSRYRSPIPLLAFTPEPATRSQLSLTWGVETF 418
Query: 429 CLEEGFDERD-----IIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
L D D + L+ G E D+V++T G P + TN +++ I
Sbjct: 419 -LGPHADSTDAMVDQVDELLTRYGRCEKGDVVVITAGSPPGVSGTTNLVRVHHI 471
>pir||C82316 pyruvate kinase I VC0485 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9654913|gb|AAF93658.1| (AE004135)
pyruvate kinase I [Vibrio cholerae]
Length = 470
Score = 303 bits (767), Expect = 3e-81
Identities = 186/475 (39%), Positives = 273/475 (57%), Gaps = 18/475 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S + +L+ G++V+RLNFSHG + EH I R + + +++A
Sbjct: 3 KTKIVCTIGPKTESVEKLTELVNAGMNVMRLNFSHGDYVEHGTRITNFRKVMEVTGKQLA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++ G V+L G++ TT VVG++ + V Y F + ++ G+
Sbjct: 63 ILLDTKGPEIRTIKLENGDDVDLVAGQEFTFTTDTKVVGNKERVAVTYSGFAKDLNVGNR 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
I + DG I + V +V+ V++ G L KG+N+P + + A++ +D +KF
Sbjct: 123 ILVDDGLIEMEVLATTDTEVKCKVLNNGALGENKGVNLPGVSVNLPALSEKDKNDLKFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV +++ L + +++ +ISKIE + + NFDEIL+ SDGIM+
Sbjct: 183 EQGVDFVAASFIRKGSDVKEIREVLASHGGQNIQIISKIENQEGLDNFDEILELSDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E + QK +I K N K VITATQML SM PTRAE DVANAI
Sbjct: 243 ARGDLGVEIPAEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAI 302
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
+DGTDAVMLS ETA GK+P++AVK+MA+IA+ T+ ++ SRL D R I EA
Sbjct: 303 MDGTDAVMLSGETAKGKYPVEAVKIMAQIAERTDPVLKAELGSRL-----DSPRLRITEA 357
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ + +D L I+ T G++AR + ++ P I +TN++ L+ S GV
Sbjct: 358 VCKGAVDTAEKLAAPLIIVATEAGKSARSVRKYFPTANIIAVTTNKKTAAQLVLSKGVTP 417
Query: 428 FCLEEGFDERDI-------IRLIKGLGLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
+ + D D I L GLG + DIV+M G + T T S+ +
Sbjct: 418 VVV-DAIDNTDAFYHLGKEIALQSGLG--KKGDIVVMVSGALVASGTTNTASVHV 469
>sp|Q92122|KPYK_XENLA PYRUVATE KINASE, MUSCLE ISOZYME (CYTOSOLIC THYROID HORMONE BINDING
PROTEIN) (CTHBP) >gi|1085221|pir||S51374 pyruvate kinase
(EC 2.7.1.40), muscle - clawed frog
>gi|433355|gb|AAA63581.1| (U03878) cytosolic thyroid
hormone binding protein/pyruvate kinase type M2 [Xenopus
laevis]
Length = 527
Score = 301 bits (763), Expect = 1e-80
Identities = 184/476 (38%), Positives = 280/476 (58%), Gaps = 32/476 (6%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ TIGPA+ S M+K++I++G+++ RLNFSHG+ E HA I+ VR+ ++ L
Sbjct: 41 TGIICTIGPASRSVEMLKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESLASNPIH 100
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T D DE + V+YK+
Sbjct: 101 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATMRITLDDAFQENCDENVLWVDYKNL 160
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L V+E+ + +GG L S+KG+N+P A + + AV+ +
Sbjct: 161 TKVVKPGSKIYVDDGLISLLVKEIGPDFCVTEIENGGMLGSKKGVNLPGAAVDLPAVSSK 220
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ ++F +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 221 DIQDLQFGVEQDVDMVFASFIRKAADVHEVREVLGEK-GKNIKIISKIENHEGVRRFDEI 279
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 280 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 339
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E +R+ F + R+
Sbjct: 340 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQLFEELRRVSP 399
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T EA A ++A + I+ T++GR+A L+SR++P+ I + N +
Sbjct: 400 LTRDPT-----EATAVGAVEASFKCSSGAIIVLTKSGRSAHLLSRYRPRAPIISVTRNGQ 454
Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ E E D+ + + K G +S D+V++ G
Sbjct: 455 TARQAHLYRGIFPVLYREAVHEAWAEDVDSRVNFAMDIGKARGFFKSGDVVIVLTG 510
>pir||T27928 hypothetical protein ZK593.1 - Caenorhabditis elegans
>gi|5824898|emb|CAA93424.2| (Z69385) Similarity to
Chicken pyruvate kinase (SW:KPYK_CHICK), contains
similarity to Pfam domain: PF00224 (Pyruvate kinase),
Score=937.4, E-value=1.3e-278, N=1~cDNA EST EMBL:T01521
comes from this gene~cDNA EST yk175h9.5 comes from this
gene~cDNA EST>
Length = 515
Score = 300 bits (760), Expect = 2e-80
Identities = 178/467 (38%), Positives = 265/467 (56%), Gaps = 19/467 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KT ++ TIGPA S ++K+I G+++ RLNFSHG+ E HA I+ +R+ ++ VA
Sbjct: 35 KTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVA 94
Query: 70 ILADLPGLKIRVGEIKGGY--VELKRGEKVVLTT---RDVVGDETTIPVEYKDFPRLVSK 124
I D G +IR G V+L+ G+ V ++T + + I +Y++ P++V
Sbjct: 95 IALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQP 154
Query: 125 GDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK 184
G IY+ DG I L VE V + +GG L +RKG+N+P + + AVT +D+E +
Sbjct: 155 GSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 214
Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
F +EQGVD I SF+ + + K++ L + + +++I+KIE D V N DEI++ASDG
Sbjct: 215 FGVEQGVDIIFASFIRNADGIHKIRQVLGEK-GKHIYIIAKIESEDGVTNCDEIIEASDG 273
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
+M+ARGDLG+E+P E++ + QK LI K N GKPVI ATQML SM + PTRAE +DVA
Sbjct: 274 VMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVA 333
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT- 363
NA+LDG D VMLS ETA G +P++A+ +M I K E F M EL+ + T
Sbjct: 334 NAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAES--AFFHMKHFEELILHTKKPTG 391
Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
+ A + + A T I+ T TG+TARL SR++P I S +ER+ L
Sbjct: 392 MTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHR 451
Query: 424 GVYAFCLEEG-FDERDI---------IRLIKGLGLVESDDIVLMTEG 460
G++ +G DE D+ + L K G + D +++ G
Sbjct: 452 GIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITG 498
>pir||D83459 pyruvate kinase I PA1498 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9947453|gb|AAG04887.1|AE004578_9
(AE004578) pyruvate kinase I [Pseudomonas aeruginosa]
Length = 477
Score = 298 bits (756), Expect = 7e-80
Identities = 174/478 (36%), Positives = 267/478 (55%), Gaps = 17/478 (3%)
Query: 8 DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
D K KI+AT+GPAT SR+ I+ L+E G +++RLNFSHG + +HA+ VR++ +L+
Sbjct: 4 DKKAKILATLGPATRSRDDIRALVEAGANLLRLNFSHGDYADHAQRFAWVREVEAELNYP 63
Query: 68 VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
+ +L DL G K+RVG G V+L+RG+ L D GDE + + + + + G
Sbjct: 64 IGVLMDLQGPKLRVGRFAAGAVQLQRGQTFTLDLSDAPGDERRVNLPHPEIIHALEPGMS 123
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG I L V +E V GG+L RKG+N+P+A L + +T +D + F +
Sbjct: 124 LLLDDGKIRLEVVNCHSDAIETRVAVGGELSDRKGVNVPEAVLQLSPLTDKDRRDLAFGL 183
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
E GVD + LSFV D+ + + + + F+++KIE+P AV + I + +D IM+
Sbjct: 184 ELGVDWVALSFVQRPEDIDEARGLI----GDKAFLMAKIEKPSAVSAIEAIAERADAIMV 239
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E +P +QK +++ GKPV+ ATQML SM PTRAEVTDVA A+
Sbjct: 240 ARGDLGVEVPAESVPGIQKRIVQVCRQLGKPVVVATQMLESMRFSPAPTRAEVTDVATAV 299
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTRGTI 364
G DAVMLS ETA G++P +AV+MMAKI + E +Y ++R + T+
Sbjct: 300 GAGADAVMLSAETASGQYPREAVEMMAKIVRQVEAEPDYHVQLEVNRPQ------PDATV 353
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
+AI+ +I L + ++ T +G + +R +PK I + N R L ++G
Sbjct: 354 SDAISCAIRRVSRILPVAVLVNYTESGNSTLRAARERPKAPILSLTPNLRTARRLTVAWG 413
Query: 425 VYAFCLEEGFDERDIIRLIKGLGLVE----SDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
VY+ E+ +I + L + D V++T G P + TN ++I +A
Sbjct: 414 VYSVVNEQLAHVDEICSTALDIALAQRMARRGDTVVVTAGVPFGRPGSTNMLRIETVA 471
>sp|P21599|KPY2_ECOLI PYRUVATE KINASE II (PK-2) >gi|321866|pir||S29790 pyruvate kinase
(EC 2.7.1.40) A - Escherichia coli
>gi|147459|gb|AAA24473.1| (M63703) pyruvate kinase type
II [Escherichia coli] >gi|1736497|dbj|BAA15662.1|
(D90828) Pyruvate kinase (EC 2.7.1.40) [Escherichia
coli] >gi|1788160|gb|AAC74924.1| (AE000279) pyruvate
kinase II, glucose stimulated [Escherichia coli K12]
Length = 480
Score = 295 bits (747), Expect = 8e-79
Identities = 195/478 (40%), Positives = 271/478 (55%), Gaps = 15/478 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKIV T+GPAT N ++K+I G +VVR+NFSHGS E+H +KVR+I+ KL R VA
Sbjct: 7 RTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVA 66
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDV 127
IL DL G KIRV K G V L G+K +L GD+ + ++YK P V GD+
Sbjct: 67 ILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDI 126
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG + L+V EV+G V V GG L + KGIN L EA+T +D IK A
Sbjct: 127 LLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIKTAA 186
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
GVD + +SF D L L ++ D +++K+ER +AV + D+I+ ASD
Sbjct: 187 LIGVDYLAVSFPRCGED-LNYARRLARDAGCDAKIVAKVERAEAVCSQDAMDDIILASDV 245
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
+M+ARGDLGVE+ L +QK LIR+A + VITATQM+ SM +PTRAEV DVA
Sbjct: 246 VMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVA 305
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
NA+LDGTDAVMLS ETA G++P + V MA++ E+ S +S+ R D +
Sbjct: 306 NAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKI-PSINVSKHR---LDVQFDNV 361
Query: 365 KEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
+EAIA S + A L + I+T T +GRTA + SR IF S +ER N
Sbjct: 362 EEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYR 421
Query: 424 GVYAFCLEEGFD----ERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
GV + D + + L++ G + S D+V++T+G + TN+ +I +
Sbjct: 422 GVTPVHFDSANDGVAAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTV 479
>sp|O44006|KPYK_EIMTE PYRUVATE KINASE (PK) >gi|2854033|gb|AAC02529.1| (AF043910) pyruvate
kinase [Eimeria tenella]
Length = 531
Score = 294 bits (746), Expect = 1e-78
Identities = 180/480 (37%), Positives = 279/480 (57%), Gaps = 16/480 (3%)
Query: 9 HKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRD-ISQKLDRR 67
H+TKIV T+GP+ + + +LI+ G++V RLNFSHG E H +V++ +++ + Q+ +R
Sbjct: 56 HRTKIVCTMGPSCWDVDKMVQLIDAGMNVCRLNFSHGDHEAHGRVVKNLQEALKQRPGKR 115
Query: 68 VAILADLPGLKIRVGEIKGGY-VELKRGEKV-VLTTRDVVGDETTIPVEYKDFPRLVSKG 125
VA+L D G +IR G ++G +EL G+ + ++T VG+++ I Y+ P V G
Sbjct: 116 VALLLDTKGPEIRTGMLEGDKPIELHAGDMLKIVTDYSFVGNKSCIACSYEKLPSSVKPG 175
Query: 126 DVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM-EIIK 184
+ I ++DG + + V E V V++ + ++K +N+P + + + +D +I+
Sbjct: 176 NTILIADGSLSVEVVECGKDYVMTRVMNPAIIGNKKNMNLPGVKVDLPVIGEKDKNDILN 235
Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
F I G + I SFV S DV ++S L ++ +I KIE + + NFDEIL+ +DG
Sbjct: 236 FGIPMGCNFIAASFVQSADDVRYIRSILGTK-GRNIKIIPKIENVEGLLNFDEILQEADG 294
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
IMIARGDLG+E+P E++ + QK +I K N GKPVITATQML SMT PTRAE DVA
Sbjct: 295 IMIARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMTKNPRPTRAEAADVA 354
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTR 361
NA+LDGTD VMLS ETA G FP+ AV +M+++ E +Y++ F + + T
Sbjct: 355 NAVLDGTDCVMLSGETANGSFPVQAVTVMSRVCFEAEGCIDYQQVFRATCQATMTPIDT- 413
Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMF 421
+EA+AR+ ++ ++N IL T TGRTARLI++++P Q I S +E L
Sbjct: 414 ---QEAVARAAVETAQSINASLILALTETGRTARLIAKYRPMQPILALSASEETIKQLQV 470
Query: 422 SYGVYAFCLE--EGFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
GV F + +G D+ R+ + K L LV D ++ G E +N +K+ +
Sbjct: 471 IRGVTTFLVPTFQGTDQLIRNALSAAKELQLVSEGDSIVAVHGIKEEVAGWSNLLKVLVV 530
>sp|Q44473|KPY4_AGRVI PYRUVATE KINASE (PK) >gi|805294|gb|AAA68700.1| (U25634) putative
pyruvate kinase; inducible by tartrate; Method:
conceptual translation supplied by author [Agrobacterium
vitis] >gi|1585265|prf||2124372E ttuE gene
[Agrobacterium vitis]
Length = 482
Score = 294 bits (746), Expect = 1e-78
Identities = 171/476 (35%), Positives = 275/476 (56%), Gaps = 12/476 (2%)
Query: 8 DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
+ ++KIVAT+GPA+SS +M++ L GV RLNFSHG+ +HA+V +R + Q+ D
Sbjct: 6 NRRSKIVATVGPASSSPDMLRSLFLAGVDTFRLNFSHGARADHAEVYRNIRALEQEHDAA 65
Query: 68 VAILADLPGLKIRVGEIKGGYVELKRGEKV-VLTTRDVVGDETTIPVEYKDFPRLVSKGD 126
+A+L DL G KIR+G + G ++L RG + + R+ IP+ +++ + G
Sbjct: 66 IAVLQDLQGPKIRIGVLAHGRLDLARGSTIGFILGREGGEGMNDIPLPHREIFEVAVPGM 125
Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
+ + DG I +R+ EV + V++GG L +RKG+N+P A L + +T +D E ++F
Sbjct: 126 DLLIDDGRIKVRIMEVMDGRLVCEVLNGGALSNRKGVNVPGAVLDISPLTAKDREDLEFG 185
Query: 187 IEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIM 246
+E GVD + LSFV D+++ +S + + +I+KIE+P A+ + ++I++ SD +M
Sbjct: 186 LELGVDWVALSFVQRARDMIEARSLV----GDRAGLIAKIEKPSALDDIEDIVRLSDSVM 241
Query: 247 IARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANA 306
+ARGDLGVE+P E +P QKE+IR KPVI ATQML SM + PTRAE +DVA A
Sbjct: 242 VARGDLGVEIPPEDVPGKQKEIIRACRLAAKPVIVATQMLDSMVSSPTPTRAEASDVAGA 301
Query: 307 ILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
I DG DAVMLS ETA G +P++AV++M +I + TE+++ + E E +
Sbjct: 302 IYDGADAVMLSAETATGAYPVEAVEIMNRIIEKTEKHKH---YRPILEATEPDVAQSPPH 358
Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
A+A + + L ++ T +G TA ISR +P I + +E+V L +GV
Sbjct: 359 AVATAAANVAVALGSPVVVAYTSSGTTAARISRARPALPILALTPSEQVARRLNMFWGVV 418
Query: 427 AFCLEEGFD-ERDII---RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
++ E +I + ++ L D +++ G P + TN++++ QIA
Sbjct: 419 GVRSQDVHTYEASLIHAQQAVQEAKLASPSDHIVIVAGFPFAQQGSTNNLRVVQIA 474
>sp|Q46078|KPYK_CORGL PYRUVATE KINASE (PK) >gi|2127424|pir||I40840 pyruvate kinase (EC
2.7.1.40) - Corynebacterium glutamicum
>gi|598097|gb|AAA56793.1| (L27126) pyruvate kinase
[Corynebacterium glutamicum]
Length = 475
Score = 293 bits (743), Expect = 2e-78
Identities = 175/471 (37%), Positives = 266/471 (56%), Gaps = 13/471 (2%)
Query: 8 DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
D +TKIV T+GPA +S + I +L+E+G+ V RLNFSHG +H + + VR+ ++K R
Sbjct: 2 DRRTKIVCTLGPAVASADGILRLVEDGMDVARLNFSHGDHPDHEQNYKWVREAAEKTGRA 61
Query: 68 VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
V ILADL G KIR+G G + GE + +T DV G + YK+ + GD
Sbjct: 62 VGILADLQGPKIRLGRFTDGATVWENGETIRITVDDVEGTHDRVSTTYKNLAKDAKPGDR 121
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG + L V G DV VV GG + + KG+++P + V A++ +D+ ++FA+
Sbjct: 122 LLVDDGKVGLVCVSVEGNDVICEVVEGGPVSNNKGVSLPGMDISVPALSEKDIRDLRFAL 181
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
+ GVD I LSFV S D V +++ + V VI+K+E+P+AV + + I+ A D +M+
Sbjct: 182 KLGVDFIALSFVRSPADAELVHKIMDE-EGRRVPVIAKLEKPEAVTSLEPIVLAFDAVMV 240
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P+E +P++QK I+ A KPVI ATQML SM PTRAE +DVANA+
Sbjct: 241 ARGDLGVEVPLEEVPLVQKRAIQIARENAKPVIVATQMLDSMIENSRPTRAEASDVANAV 300
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
LDG DAVMLS ET++GK P + V+ M++I + E R+ +L T +
Sbjct: 301 LDGADAVMLSGETSVGKDPHNVVRTMSRIVRFAET------DGRVPDLTH--IPRTKRGV 352
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
I+ S D LN + ++ T +G TA+ ++R + F+ NE V + L ++G
Sbjct: 353 ISYSARDIAERLNARALVAFTTSGDTAKRVARLHSHLPLLVFTPNEAVRSELALTWGATT 412
Query: 428 FCLEEGFDE----RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
F D R++ R + + D++++ G P T TN I +
Sbjct: 413 FLCPPVSDTDDMMREVDRALLAMPEYNKGDMMVVVAGSPPGVTGNTNMIHV 463
>sp|Q29536|KPYR_CANFA PYRUVATE KINASE, ISOZYME R >gi|7579924|gb|AAB31627.2| (S71530)
R-type pyruvate kinase; R-type PK [Canis familiaris]
Length = 519
Score = 293 bits (743), Expect = 2e-78
Identities = 172/438 (39%), Positives = 262/438 (59%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I +R+ +
Sbjct: 33 TSIIATIGPASHSVERLKEMIKAGMNIARLNFSHGSHEYHAQSIANIREAVESFATSPLG 92
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDV---VGDETTIPVEYKDF 118
R VAI D G +IR G +KGG VEL +G V++T +GD T+ V+Y +
Sbjct: 93 YRPVAIALDTKGPEIRTGVLKGGPETEVELVKGSWVLVTVDPAFRTLGDAHTVWVDYPNI 152
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G I++ DG I L+V+++ + +E V +GG L SRKG+N+P A + + ++ +
Sbjct: 153 VKVVPVGGRIFIDDGLISLQVKKIDRKGLETQVENGGLLGSRKGVNLPGAEVDLPGLSEQ 212
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D + ++F +E VD + SFV DV +++ L + + +ISKIE + V+ FDEI
Sbjct: 213 DAQDLRFGVEHNVDIVFASFVRKASDVAAIRAALGP-EGRTIKIISKIENHEGVKKFDEI 271
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 272 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 331
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA GKFP++AVKM +IA+ E +R+ F + R
Sbjct: 332 ETSDVANAVLDGADCIMLSGETAKGKFPVEAVKMQHRIAREAEAAVYHRQLFEELRRAAP 391
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A + ++A I+ T+TGR+A+L+SR++P+ + + + +
Sbjct: 392 LSRDPT-----EVTAIATVEAAFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQ 446
Query: 415 VCNNLMFSYGVYAFCLEE 432
GV+ E
Sbjct: 447 AARQAHLCRGVFPLLYSE 464
>gb|AAA60104.1| (M15465) pyruvate kinase [Homo sapiens]
Length = 543
Score = 292 bits (740), Expect = 5e-78
Identities = 173/438 (39%), Positives = 259/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I VR+ +
Sbjct: 57 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAETIANVREAVESFAGSPLS 116
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VEL +G +V++T G+ T+ V+Y +
Sbjct: 117 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 176
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V G IY+ DG I L V+++ + + V +GG L SRKG+N+P A + + ++ +
Sbjct: 177 VRVVPVGGRIYIDDGLISLVVQKISPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 236
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E GVD + SFV DV V++ L + + +ISKIE + V+ FDEI
Sbjct: 237 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 295
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 355
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM +IA+ E +R+ F + R
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHRIAREAEAAVYHRQLFEELRRAAP 415
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T TGR+A+L+SR++P+ + + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 470
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ GV+ E
Sbjct: 471 AARQVHLCRGVFPLLYRE 488
>pir||T21360 hypothetical protein F25H5.3b - Caenorhabditis elegans
>gi|3876398|emb|CAB02983.1| (Z81068) contains similarity
to Pfam domain: PF00224 (Pyruvate kinase), Score=974.5,
E-value=8.3e-290, N=1~cDNA EST yk206a12.5 comes from
this gene~cDNA EST yk437b7.5 comes from this gene~cDNA
EST yk505a11.5 comes from this gene~cDNA EST yk508d4.5
come>
Length = 600
Score = 292 bits (740), Expect = 5e-78
Identities = 180/429 (41%), Positives = 257/429 (58%), Gaps = 18/429 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
+T I+ TIGPA +S M++KLI NG+++ RLNFSHGS E HA I VR+ + D+RV
Sbjct: 117 QTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKRV 176
Query: 69 -AILADLPGLKIRVGEIKGGY---VELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRL 121
I D G +IR G + GG +EL RG + LTT + T + V+YK+ ++
Sbjct: 177 IGIALDTKGPEIRTGLLAGGASAEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKV 236
Query: 122 VSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
+S G +Y+ DG I L VEE++ V V +GG L SRKG+N+P + + AV+ +D +
Sbjct: 237 LSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCK 296
Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
++F +EQGVD I SF+ + + ++ L + + + +I+KIE + V N DEI+
Sbjct: 297 DLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEK-GKKIKIIAKIENQEGVDNADEIISE 355
Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
SDG+M+ARGDLG+E+P E++ + QK LI K N GKPVI ATQML SM + PTRAE +
Sbjct: 356 SDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGS 415
Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVED 358
DVANA+LDG D VMLS ETA G++P+DA+K+M I K E +R F EL+++
Sbjct: 416 DVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFD-----ELLQN 470
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + IA + A + + IL T TGR+A SR+KP I S + VC
Sbjct: 471 TQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCR 530
Query: 418 NLMFSYGVY 426
L GV+
Sbjct: 531 QLHLYRGVF 539
>pir||T21361 hypothetical protein F25H5.3a - Caenorhabditis elegans
>gi|3876399|emb|CAB02984.1| (Z81068) contains similarity
to Pfam domain: PF00224 (Pyruvate kinase), Score=974.5,
E-value=8.3e-290, N=1~cDNA EST EMBL:Z14697 comes from
this gene~cDNA EST EMBL:Z14403 comes from this gene~cDNA
EST yk38f5.3 comes from this gene~cDNA EST yk44e6.3
come>
Length = 562
Score = 292 bits (740), Expect = 5e-78
Identities = 180/429 (41%), Positives = 257/429 (58%), Gaps = 18/429 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
+T I+ TIGPA +S M++KLI NG+++ RLNFSHGS E HA I VR+ + D+RV
Sbjct: 79 QTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKRV 138
Query: 69 -AILADLPGLKIRVGEIKGGY---VELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRL 121
I D G +IR G + GG +EL RG + LTT + T + V+YK+ ++
Sbjct: 139 IGIALDTKGPEIRTGLLAGGASAEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKV 198
Query: 122 VSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
+S G +Y+ DG I L VEE++ V V +GG L SRKG+N+P + + AV+ +D +
Sbjct: 199 LSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCK 258
Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
++F +EQGVD I SF+ + + ++ L + + + +I+KIE + V N DEI+
Sbjct: 259 DLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEK-GKKIKIIAKIENQEGVDNADEIISE 317
Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
SDG+M+ARGDLG+E+P E++ + QK LI K N GKPVI ATQML SM + PTRAE +
Sbjct: 318 SDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGS 377
Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVED 358
DVANA+LDG D VMLS ETA G++P+DA+K+M I K E +R F EL+++
Sbjct: 378 DVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFD-----ELLQN 432
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + IA + A + + IL T TGR+A SR+KP I S + VC
Sbjct: 433 TQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCR 492
Query: 418 NLMFSYGVY 426
L GV+
Sbjct: 493 QLHLYRGVF 501
>pir||B82130 pyruvate kinase II VC2008 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9656551|gb|AAF95156.1| (AE004275)
pyruvate kinase II [Vibrio cholerae]
Length = 481
Score = 292 bits (740), Expect = 5e-78
Identities = 187/480 (38%), Positives = 275/480 (56%), Gaps = 18/480 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKIVAT+GP+T S +++ +I G +VVR+NFSHG+ E+H +KVR+I+ KL R VA
Sbjct: 7 RTKIVATLGPSTESPEILEAIIRAGANVVRMNFSHGTAEDHKNRAQKVREIAAKLGRHVA 66
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET--TIPVEYKDFPRLVSKGDV 127
+L DL G KIRV K G + L GE +L G+ T ++ ++YK P+ V D+
Sbjct: 67 LLGDLQGPKIRVSTFKEGKIILNEGEHFILDAELAKGEGTQESVGIDYKKLPQDVCNDDI 126
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG + L+V V G + V+ GG L + KGIN L +A+T +D I+ A
Sbjct: 127 LLLDDGRVQLQVMRVEGNKIHTKVLVGGPLSNNKGINKKGGGLSADALTEKDKNDIRLAA 186
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAV---RNFDEILKASDG 244
E V+ + +SF + D +K L + +++K+ER + V N D+I++ASD
Sbjct: 187 EIQVEYLAVSFPRNGED-MKFARRLAQESGLYARMVAKVERAETVSCDENIDDIVRASDV 245
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
IM+ARGDLGVE+ L +QK+LI +A + VITATQM+ SM + +PTRAEV DVA
Sbjct: 246 IMVARGDLGVEIGDPELIAVQKKLISRAKKLNRVVITATQMMESMISNPMPTRAEVMDVA 305
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMS-RLRELVEDGTRGT 363
NA+LDGTDAVMLS ETA GK+P++ VK MA++ E+ ES + R++ + T
Sbjct: 306 NAVLDGTDAVMLSGETAAGKYPVETVKAMAEVCIGAEKMIESNEQNYRIKSVFR-----T 360
Query: 364 IKEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
+EAIA S I A L +K ++T T +GRTA + SR IF S N+ N
Sbjct: 361 EEEAIAMSTIYAANHLEGVKAMVTLTESGRTALMTSRLNSVFPIFAMSANQATLNRCALL 420
Query: 423 YGVYAFCLE----EGFDER-DIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
GV F + G + + +K L+E D+V++T+G + TN ++I +
Sbjct: 421 RGVIPFYFDTKQASGLEAAIAALDALKERNLLEEGDLVIITQGDIMGVEGSTNCMRILPV 480
>pir||S64635 pyruvate kinase (EC 2.7.1.40), muscle splice form M1 - human
Length = 531
Score = 292 bits (739), Expect = 7e-78
Identities = 177/473 (37%), Positives = 275/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V RLNFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPPPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F ELV
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELVRA 401
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 402 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTAR 461
Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 462 QAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514
>gb|AAG21457.1|AC021894_17 (AC021894) Pyruvate Kinase copy 2 [Leishmania major]
Length = 499
Score = 292 bits (739), Expect = 7e-78
Identities = 172/456 (37%), Positives = 259/456 (56%), Gaps = 17/456 (3%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
T+IV TIGP+T S +K LI++G+SV R+NFSHGS E H I VR + +L +AI
Sbjct: 22 TRIVCTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAI 81
Query: 71 LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDV 127
D G +IR G+ GG ++RG +TT D+ T ++Y++ ++V G
Sbjct: 82 ALDTKGPEIRTGQFVGGEAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGSY 141
Query: 128 IYLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
IY+ DG ++L V+ Q ++ V + + R+G+N+P + + AV+ +D ++F
Sbjct: 142 IYIDDGILILHVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFG 201
Query: 187 IEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIM 246
+EQGVD I SF+ S V V+ L D+ +I KIE V+N D I++ SDGIM
Sbjct: 202 VEQGVDMIFASFIRSAEQVGDVRKALGAK-GHDIMIICKIENHQGVQNIDSIIEESDGIM 260
Query: 247 IARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANA 306
+ARGDLGVE+P E++ + QK LI K N GKPVI ATQML SMT PTRAEV+DVANA
Sbjct: 261 VARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANA 320
Query: 307 ILDGTDAVMLSEETAIGKFPIDAVKMMAKIA----KVTEEYRESFGMSRLRELVEDGTRG 362
+ +G D VMLS ETA GK+P + V+ MA+I EY + +L+ +
Sbjct: 321 VFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVFFNSIKKLQPIPM----- 375
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
+ +EA+ S ++++ K ++ + TGR+ARL+++++P I +T + C L +
Sbjct: 376 SAEEAVCSSAVNSVYETKAKVMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNIT 435
Query: 423 YGVYAFCLEE---GFDERDIIRLIKGLGLVESDDIV 455
GV + + G DE R+ G+G +S V
Sbjct: 436 QGVESVFFDAEKLGHDEGKEQRVAMGVGFAKSKGYV 471
>sp|P94939|KPYK_MYCIT PYRUVATE KINASE (PK) >gi|1750255|gb|AAB39214.1| (U65430) pyruvate
kinase [Mycobacterium intracellulare]
Length = 472
Score = 291 bits (738), Expect = 9e-78
Identities = 181/470 (38%), Positives = 262/470 (55%), Gaps = 12/470 (2%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
KIV T+GPAT+S +I L+E G+ V RLNFSHG + +H E+VR S R V +L
Sbjct: 6 KIVCTLGPATNSDELILALVEAGMDVARLNFSHGDYADHKAAYERVRVASDATGRAVGVL 65
Query: 72 ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYLS 131
ADL G KIR+G G GE V +T D G + YK + GD + +
Sbjct: 66 ADLQGPKIRLGRFATGPTYWADGETVRITVADCEGSHDRVSTTYKKLAEDAAVGDRVLVD 125
Query: 132 DGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGV 191
DG + L V+ + G DV VV GG + + KGI++P + A++ +D+E + FA++ GV
Sbjct: 126 DGKVCLVVDGIEGDDVICTVVEGGPVSNNKGISLPGMNVSAPALSEKDIEDLTFALDLGV 185
Query: 192 DAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGD 251
D + LSFV S DV V +++ V VI+K+E+P+AV N + I+ A D IM+ARGD
Sbjct: 186 DLVALSFVRSPADVELVHEVMDR-VGRRVPVIAKLEKPEAVDNLETIVLAFDAIMVARGD 244
Query: 252 LGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGT 311
LGVE+P+E +P++QK I+ A KPVI ATQML SM PTRAE +DVANA+LDG
Sbjct: 245 LGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGA 304
Query: 312 DAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIARS 371
DAVMLS ET++GK+P+ AV+ M++I E+ S L V RG I A AR
Sbjct: 305 DAVMLSGETSVGKYPMAAVRTMSRIICAVED--NSTAAPPLTH-VPRTKRGVISYA-ARD 360
Query: 372 IIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCL- 430
I + L+ K ++ T++G T + ++R + F+ V + L ++G F +
Sbjct: 361 IGE---RLDAKALVAFTQSGDTVKRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVP 417
Query: 431 ---EEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
G R + + + LG + D+V++ G P TN I + +I
Sbjct: 418 MMTSTGGMIRQVDKSLLELGRYKRGDLVVIVAGAPPGTVGSTNLIHVHRI 467
>sp|P11979|KPY1_FELCA PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
>gi|89089|pir||A25091 pyruvate kinase (EC 2.7.1.40),
muscle splice form M1 [validated] - cat
>gi|1311281|pdb|1PKM| Pyruvate Kinase Mol_id: 1;
Molecule: M1 Pyruvate Kinase; Chain: Null; Synonym: Pk;
Ec: 2.7.1.40
Length = 530
Score = 291 bits (737), Expect = 1e-77
Identities = 176/473 (37%), Positives = 274/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ TIGPA+ S ++K++I++G++V RLNFSHG+ E HA+ I+ VR ++
Sbjct: 44 TGIICTIGPASRSVEILKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIR 103
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENVLWLDYKNI 163
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L V+E + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVEVGSKVYVDDGLISLLVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 223
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 282
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 342
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F ELV
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELVRG 400
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460
Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKHGDVVIVLTG 513
>sp|P34038|KPYK_LACDE PYRUVATE KINASE >gi|1154865|emb|CAA50527.1| (X71403) pyruvate
kinase [Lactobacillus delbrueckii]
Length = 589
Score = 291 bits (736), Expect = 1e-77
Identities = 172/472 (36%), Positives = 268/472 (56%), Gaps = 8/472 (1%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV+T+GPA+ I KL E G +V R NFSHG+ EEH + VR++ +K + +
Sbjct: 3 KTKIVSTLGPASDDIETITKLAEAGANVFRFNFSHGNHEEHLARMNMVREVEKKTGKLLG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKV-VLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
I D G +IR + +GG + G+++ V G++ I V Y G +
Sbjct: 63 IALDTKGAEIRTTDQEGGKFTINTGDEIRVSMDATKAGNKDMIHVTYPGLFDDTHVGGTV 122
Query: 129 YLSDGYIVLRVEEVRGQDVEAV--VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
+ DG + L ++ + E V + G + S+KG+N P + + +T +D + I+F
Sbjct: 123 LIDDGAVGLTIKAKDEEKRELVCEAQNTGVIGSKKGVNAPGVEIRLPGITEKDTDDIRFG 182
Query: 187 IEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIM 246
++ G++ I SFV DVL +++ E+ +A V + KIE + + N DEIL+ SDG+M
Sbjct: 183 LKHGINFIFASFVRKAQDVLDIRALCEEANASYVKIFPKIESQEGIDNIDEILQVSDGLM 242
Query: 247 IARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANA 306
+ARGD+GVE+P +P +QK LI+K N GKPVITATQML SM PTRAEVTDVANA
Sbjct: 243 VARGDMGVEIPFINVPFVQKTLIKKCNALGKPVITATQMLDSMQENPRPTRAEVTDVANA 302
Query: 307 ILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
+LDGTDA MLS E+A G +P+ +V+ M I TE+ ++ L+ E+ + E
Sbjct: 303 VLDGTDATMLSGESANGLYPVQSVQAMHDIDVRTEKELDTRNTLALQRF-EEYKGSNVTE 361
Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
AI S++ L +K I+ T +G TAR+IS+++P I + +E++ ++L +GV
Sbjct: 362 AIGESVVRTAQELGVKTIIAATSSGYTARMISKYRPDATIVALTFDEKIQHSLGIVWGVE 421
Query: 427 AFCLEE--GFDE--RDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
++ DE + R+ K G V+ D+V++ G P ++ TN +K+
Sbjct: 422 PVLAKKPSNTDEMFEEAARVAKEHGFVKDGDLVIIVAGVPFGQSGTTNLMKL 473
>gb|AAA92535.1| (U47654) pyruvate kinase PK-R isoenzyme [Homo sapiens]
Length = 587
Score = 290 bits (734), Expect = 3e-77
Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I VR+ +
Sbjct: 101 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 160
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VEL +G +V++T G+ T+ V+Y +
Sbjct: 161 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 220
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V G IY+ DG I L V+++ + + V +GG L SRKG+N+P A + + ++ +
Sbjct: 221 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 280
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E GVD + SFV DV V++ L + + +ISKIE + V+ FDEI
Sbjct: 281 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 339
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 340 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 399
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM IA+ E +R+ F + R
Sbjct: 400 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 459
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T TGR+A+L+SR++P+ + + + +
Sbjct: 460 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 514
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ GV+ E
Sbjct: 515 AARQVHLCRGVFPLLYRE 532
>gb|AAA92536.1| (U47654) pyruvate kinase PK-L isoenzyme [Homo sapiens]
Length = 566
Score = 290 bits (734), Expect = 3e-77
Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I VR+ +
Sbjct: 80 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 139
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VEL +G +V++T G+ T+ V+Y +
Sbjct: 140 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 199
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V G IY+ DG I L V+++ + + V +GG L SRKG+N+P A + + ++ +
Sbjct: 200 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 259
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E GVD + SFV DV V++ L + + +ISKIE + V+ FDEI
Sbjct: 260 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 318
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 319 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 378
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM IA+ E +R+ F + R
Sbjct: 379 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 438
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T TGR+A+L+SR++P+ + + + +
Sbjct: 439 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 493
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ GV+ E
Sbjct: 494 AARQVHLCRGVFPLLYRE 511
>pir||A30150 pyruvate kinase (EC 2.7.1.40) isoform R (erythroid) - human
>gi|3449054|dbj|BAA02515.1| (D13243) pyruvate kinase L
[Homo sapiens]
Length = 599
Score = 290 bits (734), Expect = 3e-77
Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I VR+ +
Sbjct: 113 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 172
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VEL +G +V++T G+ T+ V+Y +
Sbjct: 173 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 232
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V G IY+ DG I L V+++ + + V +GG L SRKG+N+P A + + ++ +
Sbjct: 233 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 292
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E GVD + SFV DV V++ L + + +ISKIE + V+ FDEI
Sbjct: 293 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 351
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 352 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 411
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM IA+ E +R+ F + R
Sbjct: 412 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 471
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T TGR+A+L+SR++P+ + + + +
Sbjct: 472 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 526
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ GV+ E
Sbjct: 527 AARQVHLCRGVFPLLYRE 544
>gi|10835121 pyruvate kinase, liver and RBC; Pyruvate kinase, liver and RBC type
[Homo sapiens] >gi|8247933|sp|P30613|KPYR_HUMAN PYRUVATE
KINASE, ISOZYMES R/L >gi|3327365|dbj|BAA31706.1|
(AB015983) pyruvate kinase L [Homo sapiens]
Length = 574
Score = 290 bits (734), Expect = 3e-77
Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I VR+ +
Sbjct: 88 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 147
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VEL +G +V++T G+ T+ V+Y +
Sbjct: 148 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 207
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V G IY+ DG I L V+++ + + V +GG L SRKG+N+P A + + ++ +
Sbjct: 208 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 267
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E GVD + SFV DV V++ L + + +ISKIE + V+ FDEI
Sbjct: 268 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 326
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRA 386
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM IA+ E +R+ F + R
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 446
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T TGR+A+L+SR++P+ + + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 501
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ GV+ E
Sbjct: 502 AARQVHLCRGVFPLLYRE 519
>pir||KIHUPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice form R - human
Length = 574
Score = 290 bits (734), Expect = 3e-77
Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I VR+ +
Sbjct: 88 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 147
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VEL +G +V++T G+ T+ V+Y +
Sbjct: 148 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 207
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V G IY+ DG I L V+++ + + V +GG L SRKG+N+P A + + ++ +
Sbjct: 208 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 267
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E GVD + SFV DV V++ L + + +ISKIE + V+ FDEI
Sbjct: 268 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 326
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM IA+ E +R+ F + R
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 446
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T TGR+A+L+SR++P+ + + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 501
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ GV+ E
Sbjct: 502 AARQVHLCRGVFPLLYRE 519
>pir||KIHUPL pyruvate kinase (EC 2.7.1.40), hepatic splice form L - human
Length = 543
Score = 290 bits (734), Expect = 3e-77
Identities = 173/438 (39%), Positives = 258/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S +K++I+ G+++ RLNFSHGS E HA+ I VR+ +
Sbjct: 57 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 116
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VEL +G +V++T G+ T+ V+Y +
Sbjct: 117 YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 176
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V G IY+ DG I L V+++ + + V +GG L SRKG+N+P A + + ++ +
Sbjct: 177 VRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQ 236
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E GVD + SFV DV V++ L + + +ISKIE + V+ FDEI
Sbjct: 237 DVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEI 295
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM IA+ E +R+ F + R
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 415
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T TGR+A+L+SR++P+ + + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ 470
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ GV+ E
Sbjct: 471 AARQVHLCRGVFPLLYRE 488
>sp|P11980|KPY1_RAT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
>gi|92715|pir||B26186 pyruvate kinase (EC 2.7.1.40)
isozyme M1 - rat >gi|56929|emb|CAA33799.1| (X15800)
pyruvate kinase [Rattus norvegicus]
>gi|206204|gb|AAB93666.1| (M24359) M1 pyruvate kinase
[Rattus norvegicus]
Length = 531
Score = 289 bits (733), Expect = 3e-77
Identities = 179/473 (37%), Positives = 275/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S M+K++I++G++V RLNFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V+E + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F EL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAVFHRLLFEELARA 401
Query: 359 GTRGTIK-EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
++ T EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 402 SSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTAR 461
Query: 418 NLMFSYGVY-AFCLEEGFD--ERDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ C + D D+ + + K G + D+V++ G
Sbjct: 462 QAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514
>sp|P11981|KPY2_RAT PYRUVATE KINASE, M2 ISOZYME >gi|92716|pir||A26186 pyruvate kinase
(EC 2.7.1.40) isozyme M2 - rat >gi|206205|gb|AAB93667.1|
(M24359) M2 pyruvate kinase [Rattus norvegicus]
Length = 531
Score = 289 bits (732), Expect = 4e-77
Identities = 181/476 (38%), Positives = 278/476 (58%), Gaps = 32/476 (6%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S M+K++I++G++V RLNFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V+E + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458
Query: 415 VCNNLMFSYGVY-AFCLEEGFD--ERDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ C + D D+ + + K G + D+V++ G
Sbjct: 459 TARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514
>gb|AAA41882.1| (M17091) R-pyruvate kinase [Rattus norvegicus]
Length = 574
Score = 289 bits (732), Expect = 4e-77
Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I +R+ ++
Sbjct: 88 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAEYIANIREATESFATSPLS 147
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
R VAI D G +IR G ++GG VE+ +G +V++T GD T+ V+Y +
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 207
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V+ G IY+ DG I L V+++ + + V GG L SRKG+N+P + + ++ +
Sbjct: 208 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 267
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F ++ VD I SFV DVL V+ L + +++ +ISKIE + V+ FDEI
Sbjct: 268 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKRFDEI 326
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AV M IA+ E +R+ F + R
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 446
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T+TGR+A+L+S+++P+ + + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 501
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ S GV+ E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519
>gb|AAA41883.1| (M17091) L-pyruvate kinase [Rattus norvegicus]
Length = 543
Score = 289 bits (732), Expect = 4e-77
Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I +R+ ++
Sbjct: 57 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAEYIANIREATESFATSPLS 116
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
R VAI D G +IR G ++GG VE+ +G +V++T GD T+ V+Y +
Sbjct: 117 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 176
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V+ G IY+ DG I L V+++ + + V GG L SRKG+N+P + + ++ +
Sbjct: 177 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 236
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F ++ VD I SFV DVL V+ L + +++ +ISKIE + V+ FDEI
Sbjct: 237 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKRFDEI 295
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AV M IA+ E +R+ F + R
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 415
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T+TGR+A+L+S+++P+ + + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 470
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ S GV+ E
Sbjct: 471 AARQVHLSRGVFPLLYRE 488
>gi|6981360 pyruvate kinase, liver and RBC [Rattus norvegicus]
>gi|66856|pir||KIRTPL pyruvate kinase (EC 2.7.1.40),
hepatic splice form L - rat >gi|57854|emb|CAA27158.1|
(X03430) put. L-type pyruvate kinase (aa 1-543) [Rattus
norvegicus] >gi|206202|gb|AAA41881.1| (M17685) L-type
pyruvate kinase [Rattus norvegicus]
>gi|297533|emb|CAA29169.1| (X05684) L-type pyruvate
kinase [Rattus norvegicus]
Length = 543
Score = 289 bits (731), Expect = 6e-77
Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I +R+ ++
Sbjct: 57 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 116
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
R VAI D G +IR G ++GG VE+ +G +V++T GD T+ V+Y +
Sbjct: 117 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 176
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V+ G IY+ DG I L V+++ + + V GG L SRKG+N+P + + ++ +
Sbjct: 177 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 236
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F ++ VD I SFV DVL V+ L + +++ +ISKIE + V+ FDEI
Sbjct: 237 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFDEI 295
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AV M IA+ E +R+ F + R
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 415
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T+TGR+A+L+S+++P+ + + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 470
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ S GV+ E
Sbjct: 471 AARQVHLSRGVFPLLYRE 488
>pir||A23612 pyruvate kinase (EC 2.7.1.40) L - rat >gi|206199|gb|AAA41880.1|
(M11709) L-type pyruvate kinase [Rattus norvegicus]
>gi|224883|prf||1203257A kinase L,pyruvate [Rattus
norvegicus]
Length = 543
Score = 289 bits (731), Expect = 6e-77
Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I +R+ ++
Sbjct: 57 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 116
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
R VAI D G +IR G ++GG VE+ +G +V++T GD T+ V+Y +
Sbjct: 117 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 176
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V+ G IY+ DG I L V+++ + + V GG L SRKG+N+P + + ++ +
Sbjct: 177 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 236
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F ++ VD I SFV DVL V+ L + +++ +ISKIE + V+ FDEI
Sbjct: 237 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFDEI 295
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 296 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 355
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AV M IA+ E +R+ F + R
Sbjct: 356 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 415
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T+TGR+A+L+S+++P+ + + + +
Sbjct: 416 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTGSAK 470
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ S GV+ E
Sbjct: 471 AARQVHLSRGVFPLLYRE 488
>sp|P12928|KPYR_RAT PYRUVATE KINASE, ISOZYMES R/L (L-PK)
Length = 574
Score = 289 bits (731), Expect = 6e-77
Identities = 170/438 (38%), Positives = 261/438 (58%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I +R+ ++
Sbjct: 88 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 147
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
R VAI D G +IR G ++GG VE+ +G +V++T GD T+ V+Y +
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 207
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V+ G IY+ DG I L V+++ + + V GG L SRKG+N+P + + ++ +
Sbjct: 208 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 267
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F ++ VD I SFV DVL V+ L + +++ +ISKIE + V+ FDEI
Sbjct: 268 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFDEI 326
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AV M IA+ E +R+ F + R
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 446
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T+TGR+A+L+S+++P+ + + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 501
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ S GV+ E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519
>sp|P70789|KPY3_AGRVI PYRUVATE KINASE (PK) >gi|984370|gb|AAB61625.1| (U32375) pyruvate
kinase [Agrobacterium vitis]
Length = 474
Score = 288 bits (730), Expect = 8e-77
Identities = 175/479 (36%), Positives = 269/479 (55%), Gaps = 22/479 (4%)
Query: 8 DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
+ + KIVAT+GPA+SS +++ L GV RLNFSHGS ++HA +R + ++L
Sbjct: 6 NRRAKIVATVGPASSSPAILRSLFLAGVDTFRLNFSHGSRDDHAAAYRHIRALEKELGTS 65
Query: 68 VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET-----TIPVEYKDFPRLV 122
+ IL DL G KIR+G + G ++L + ++ R V G E IP+ +++ V
Sbjct: 66 IGILQDLQGPKIRIGVLHEGRLQLTKDAEI----RFVCGTEPGRGLMDIPLPHREIFAAV 121
Query: 123 SKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI 182
GD + + DG + +R V + ++A V+ G + +RKG+N+P L + +TP+D +
Sbjct: 122 KPGDDLLIDDGRVRVRALGVSDEFIDAKVIVAGPISNRKGVNLPGTVLDISPLTPKDRKD 181
Query: 183 IKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
++F +E GVD I LSFV + D+++ +S + ++ +I+KIE+P A+ D+I+ S
Sbjct: 182 LEFGLELGVDWIALSFVQTARDMIEARSLV----SDRAGLIAKIEKPSALDEIDDIVALS 237
Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
D IM+ARGDLGVE+P E +P QKELIR KPVI ATQML SM PTRAE +D
Sbjct: 238 DAIMVARGDLGVEIPPEDVPGRQKELIRACRIAAKPVIVATQMLDSMVTSPTPTRAEASD 297
Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
VA AI DG DAVMLS E+A G FP++ V++M++I + TE+++ + E E
Sbjct: 298 VAGAIYDGADAVMLSAESATGAFPVETVEIMSRIIEKTEKHK---FYRPILEATEPQIAH 354
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
T A+A + D L I+ T +G TA ISR +P I + +E+ L
Sbjct: 355 TPPHAVATAAADVALALKAPVIVAFTVSGTTASRISRARPPLPILALTPSEQTARQLGLM 414
Query: 423 YGVYAFCLEEGFD--ERDIIRLIKG---LGLVESDDIVLMTEGKPIEKTMGTNSIKIFQ 476
+GV + L D E+ + R + GL E D +++ G P TN++++ Q
Sbjct: 415 WGVVSL-LSPTVDTYEQSVDRATQAAVQTGLAEKSDQIVVVTGFPFATAGSTNNLRVTQ 472
>pdb|1A49|A Chain A, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
>gi|4929840|pdb|1A49|B Chain B, Bis Mg-Atp-K-Oxalate
Complex Of Pyruvate Kinase >gi|4929841|pdb|1A49|C Chain
C, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
>gi|4929842|pdb|1A49|D Chain D, Bis Mg-Atp-K-Oxalate
Complex Of Pyruvate Kinase >gi|4929843|pdb|1A49|E Chain
E, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
>gi|4929844|pdb|1A49|F Chain F, Bis Mg-Atp-K-Oxalate
Complex Of Pyruvate Kinase >gi|4929845|pdb|1A49|G Chain
G, Bis Mg-Atp-K-Oxalate Complex Of Pyruvate Kinase
>gi|4929846|pdb|1A49|H Chain H, Bis Mg-Atp-K-Oxalate
Complex Of Pyruvate Kinase >gi|4557921|pdb|1A5U|A Chain
A, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
>gi|4557922|pdb|1A5U|B Chain B, Pyruvate Kinase Complex
With Bis Mg-Atp-Na-Oxalate >gi|4557923|pdb|1A5U|C Chain
C, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
>gi|4557924|pdb|1A5U|D Chain D, Pyruvate Kinase Complex
With Bis Mg-Atp-Na-Oxalate >gi|4557925|pdb|1A5U|E Chain
E, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
>gi|4557926|pdb|1A5U|F Chain F, Pyruvate Kinase Complex
With Bis Mg-Atp-Na-Oxalate >gi|4557927|pdb|1A5U|G Chain
G, Pyruvate Kinase Complex With Bis Mg-Atp-Na-Oxalate
>gi|4557928|pdb|1A5U|H Chain H, Pyruvate Kinase Complex
With Bis Mg-Atp-Na-Oxalate >gi|3659945|pdb|1AQF|A Chain
A, Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|3659946|pdb|1AQF|B Chain B,
Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|3659947|pdb|1AQF|C Chain C,
Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|3659948|pdb|1AQF|D Chain D,
Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|3659950|pdb|1AQF|F Chain F,
Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|3659951|pdb|1AQF|G Chain G,
Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|3659952|pdb|1AQF|H Chain H,
Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|3659949|pdb|1AQF|E Chain E,
Pyruvate Kinase From Rabbit Muscle With Mg, K, And
L-Phospholactate >gi|2231167|gb|AAB61963.1| (U09028)
muscle pyruvate kinase [Oryctolagus cuniculus]
Length = 530
Score = 288 bits (730), Expect = 8e-77
Identities = 174/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V R+NFSHG+ E HA+ I+ VR ++ L
Sbjct: 44 TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F EL
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 400
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460
Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513
>sp|P11974|KPY1_RABIT PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
Length = 531
Score = 288 bits (730), Expect = 8e-77
Identities = 174/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V R+NFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F EL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 401
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 402 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 461
Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 462 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514
>gb|AAC48536.1| (U44751) pyruvate kinase [Oryctolagus cuniculus]
>gi|1589159|prf||2210328A pyruvate kinase [Oryctolagus
cuniculus]
Length = 530
Score = 287 bits (728), Expect = 1e-76
Identities = 174/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V R+NFSHG+ E HA+ I+ VR ++ L
Sbjct: 44 TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F EL
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARA 400
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460
Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513
>sp|O06134|KPYK_MYCTU PYRUVATE KINASE (PK) >gi|7434446|pir||G70557 probable pykA protein
- Mycobacterium tuberculosis (strain H37RV)
>gi|2113901|emb|CAB08894.1| (Z95554) pykA [Mycobacterium
tuberculosis]
Length = 472
Score = 287 bits (728), Expect = 1e-76
Identities = 175/470 (37%), Positives = 259/470 (54%), Gaps = 12/470 (2%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
KIV T+GPAT ++++ L+E G+ V R+NFSHG +++H E+VR S R V +L
Sbjct: 6 KIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAVGVL 65
Query: 72 ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYLS 131
ADL G KIR+G G GE V +T G + YK + GD + +
Sbjct: 66 ADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDRVSTTYKRLAQDAVAGDRVLVD 125
Query: 132 DGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGV 191
DG + L V+ V G DV VV GG + KGI++P + A++ +D+E + FA+ GV
Sbjct: 126 DGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGV 185
Query: 192 DAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGD 251
D + LSFV S DV V +++ V VI+K+E+P+A+ N + I+ A D +M+ARGD
Sbjct: 186 DMVALSFVRSPADVELVHEVMDR-IGRRVPVIAKLEKPEAIDNLEAIVLAFDAVMVARGD 244
Query: 252 LGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGT 311
LGVE+P+E +P++QK I+ A KPVI ATQML SM PTRAE +DVANA+LDG
Sbjct: 245 LGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGA 304
Query: 312 DAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIARS 371
DA+MLS ET++GK+P+ AV+ M++I EE S L + RG I A AR
Sbjct: 305 DALMLSGETSVGKYPLAAVRTMSRIICAVEE--NSTAAPPLTHIPRT-KRGVISYA-ARD 360
Query: 372 IIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLE 431
I + L+ K ++ T++G T R ++R + F+ V + L ++G F +
Sbjct: 361 IGE---RLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVP 417
Query: 432 EGFDERDIIRLIK----GLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
+ +IR + L + D+V++ G P TN I + +I
Sbjct: 418 KMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRI 467
>sp|P14618|KPY1_HUMAN PYRUVATE KINASE, M1 ISOZYME (PYRUVATE KINASE MUSCLE ISOZYME)
(CYTOSOLIC THYROID HORMONE-BINDING PROTEIN) (CTHBP)
(THBP1) >gi|478822|pir||S30038 pyruvate kinase (EC
2.7.1.40), muscle splice form M2 - human
>gi|35505|emb|CAA39849.1| (X56494) pyruvate kinase [Homo
sapiens]
Length = 531
Score = 287 bits (727), Expect = 2e-76
Identities = 178/476 (37%), Positives = 277/476 (57%), Gaps = 32/476 (6%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V RLNFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPPPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458
Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 459 TARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514
>pir||B81239 pyruvate kinase II NMB0089 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225307|gb|AAF40552.1|
(AE002368) pyruvate kinase II [Neisseria meningitidis
MC58]
Length = 490
Score = 287 bits (726), Expect = 2e-76
Identities = 178/479 (37%), Positives = 272/479 (56%), Gaps = 12/479 (2%)
Query: 9 HKTKIVATIGPATSSRNMIKKLIE-NGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
H TKIVAT+GP +++ +++ +I G++VVR NFSHG+ E H + VR+ +++ +
Sbjct: 13 HNTKIVATLGPGSNNVELLEDMIRVGGLNVVRFNFSHGTPEFHQENALIVREAAKRAGQE 72
Query: 68 VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGD 126
+AI+ADL G KIRVG+I GG +EL +GE +VL + G + ++Y+D P V+ GD
Sbjct: 73 IAIIADLQGPKIRVGKIAGGGIELNKGETLVLDAALEGEGTREAVGLDYRDLPDDVAAGD 132
Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
V++L DG + L VE V G + V + L S KGIN L A+T +D +K A
Sbjct: 133 VLWLDDGLLTLTVESVEGSRIITRVENSHVLKSNKGINKRGGGLSAGALTEKDFRDLKTA 192
Query: 187 IEQGVDAIGLSFVGSVYDV----LKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
I G D + +SFV S D+ KV+ ++ + A ++SKIER +A+ N DEI+ A
Sbjct: 193 IAIGCDYLAISFVKSAEDLHIARAKVEEEMKGSTAVRPGLVSKIERVEAIENLDEIILAG 252
Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
DGIM+ARGDL VE+ +P LQK +IR+A + ITATQM+ SM VPTRAEV+D
Sbjct: 253 DGIMVARGDLAVEVGHAAVPALQKRMIRRARELRRFSITATQMMESMITNPVPTRAEVSD 312
Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
VANA+LDGTDAVM S ETA+G +P + V MA I E+ ++S ++ + E VE
Sbjct: 313 VANAVLDGTDAVMCSAETAVGAYPFETVSQMAIICAAAEKEQDS--LNGVAEQVEYPEAV 370
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
+ A+A + ++ K I+ T +G TA ISR IF + + +
Sbjct: 371 STNLAVAGGAVSVARAVHAKAIVALTESGSTAFEISRHNITLPIFALTPSVSAQRRMAMY 430
Query: 423 YGVYAFCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
GV L D + ++ + ++ S D ++T G + ++ TN++++ ++
Sbjct: 431 RGVRPLILATSTDHDTALNEVETMLVEHNILHSGDQYIITSGSQMRESGSTNTLEVLRV 489
>pir||KIRTPR pyruvate kinase (EC 2.7.1.40), erythrocyte splice form R - rat
Length = 574
Score = 287 bits (726), Expect = 2e-76
Identities = 169/438 (38%), Positives = 261/438 (59%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I +R+ ++
Sbjct: 88 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 147
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTR---DVVGDETTIPVEYKDF 118
R VAI D G +IR G ++GG VE+ +G +V++T GD T+ V+Y +
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 207
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
R+V+ G IY+ DG I L V+++ + + V GG L SRKG+N+P + + ++ +
Sbjct: 208 TRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQ 267
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F ++ VD I SFV DVL V+ L + +++ +ISKIE + V+ F+EI
Sbjct: 268 DLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGP-EGQNIKIISKIENHEGVKKFNEI 326
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 327 LEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AV M IA+ E +R+ F + R
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAP 446
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T+TGR+A+L+S+++P+ + + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQ 501
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ S GV+ E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519
>sp|P00548|KPYK_CHICK PYRUVATE KINASE, MUSCLE ISOZYME >gi|66858|pir||KICHPM pyruvate
kinase (EC 2.7.1.40), muscle - chicken
>gi|212571|gb|AAA49020.1| (M18793) pyruvate kinase
[Gallus gallus] >gi|212573|gb|AAA49021.1| (J00903)
pyruvate kinase [Gallus gallus]
Length = 530
Score = 287 bits (726), Expect = 2e-76
Identities = 176/473 (37%), Positives = 272/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ TIGPA+ S + +K++I++G++V RLNFSHG+ E H I+ VR+ ++
Sbjct: 44 TGIICTIGPASRSVDKLKEMIKSGMNVARLNFSHGTHEYHEGTIKNVREATESFASDPIT 103
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VAI D G +IR G IKG VELK+G + +T + DE + V+YK+
Sbjct: 104 YRPVAIALDTKGPEIRTGLIKGSGTAEVELKKGAALKVTLDNAFMENCDENVLWVDYKNL 163
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
+++ G IY+ DG I L V+E V V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 IKVIDVGSKIYVDDGLISLLVKEKGKDFVMTEVENGGMLGSKKGVNLPGAAVDLPAVSEK 223
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV V+ L + + + +ISKIE + VR FDEI
Sbjct: 224 DIQDLKFGVEQNVDMVFASFIRKAADVHAVRKVLGEK-GKHIKIISKIENHEGVRRFDEI 282
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
++ASDGIM+ARGDLG+E+P E++ + QK +I + N GKP+I ATQML SM + PTRA
Sbjct: 283 MEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPIICATQMLESMIKKPRPTRA 342
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F + E++
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAE--AAMFHRQQFEEILRH 400
Query: 359 GT-RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+A+A ++A ++ T +GR+A L+SR++P+ I + N++
Sbjct: 401 SVHHREPADAMAAGAVEASFKCLAAALIVMTESGRSAHLVSRYRPRAPIIAVTRNDQTAR 460
Query: 418 NLMFSYGVY-AFCLEEGFD--ERDI-------IRLIKGLGLVESDDIVLMTEG 460
GV+ C + D D+ + + K G ++ D+V++ G
Sbjct: 461 QAHLYRGVFPVLCKQPAHDAWAEDVDLRVNLGMNVGKARGFFKTGDLVIVLTG 513
>gi|4505839 pyruvate kinase, muscle; Pyruvate kinase-3; Thyroid hormone-binding
protein, cytosolic (p58) [Homo sapiens]
>gi|125604|sp|P14786|KPY2_HUMAN PYRUVATE KINASE, M2
ISOZYME >gi|88544|pir||JT0486 pyruvate kinase (EC
2.7.1.40) M2 - human >gi|189998|gb|AAA36449.1| (M23725)
M2-type pyruvate kinase [Homo sapiens]
Length = 531
Score = 287 bits (726), Expect = 2e-76
Identities = 178/476 (37%), Positives = 277/476 (57%), Gaps = 32/476 (6%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V RLNFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458
Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 459 TARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514
>pdb|1PKN| Pyruvate Kinase (E.C.2.7.1.40) Complexed With Manganese,
Potassium, And Pyruvate
Length = 530
Score = 287 bits (726), Expect = 2e-76
Identities = 172/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V R+NFSHG+ E HA+ I+ VR ++ L
Sbjct: 44 TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDV---VGDETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMAACDENILWLDYKNI 163
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVEVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +++ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 224 DIQDLKFGVDEDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F EL
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 400
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460
Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKAAGFFKKGDVVIVLTG 513
>gi|8567390 pyruvate kinase liver and red blood cell [Mus musculus]
>gi|1730067|sp|P53657|KPYR_MOUSE PYRUVATE KINASE,
ISOZYMES R/L (L-PK) >gi|1174313|gb|AAB35435.1| (S79731)
pyruvate kinase, PK [mice, CBA, Peptide, 574 aa] [Mus
sp.] >gi|2653561|dbj|BAA23642.1| (D63764) pyruvate
kinase [Mus musculus]
Length = 574
Score = 287 bits (726), Expect = 2e-76
Identities = 171/438 (39%), Positives = 260/438 (59%), Gaps = 22/438 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLD----- 65
T I+ATIGPA+ S + +K++I+ G+++ RLNFSHGS E HA+ I +R+ ++
Sbjct: 88 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLS 147
Query: 66 -RRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVV---GDETTIPVEYKDF 118
R VAI D G +IR G ++GG VE+ +G +V++T GD T+ V+Y +
Sbjct: 148 YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNI 207
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V+ G IY+ DG I L V ++ + + V GG L +RKG+N+P A + + ++ +
Sbjct: 208 TQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQ 267
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D+ ++F +E VD I SFV DV+ V+ L + + +ISKIE + V+ FDEI
Sbjct: 268 DLLDLRFGVEHYVDIIFASFVRKASDVVAVRDALGP-EGRGIKIISKIENHEGVKKFDEI 326
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ SDGIM+ARGDLG+E+P E++ + QK +I + N GKPV+ ATQML SM + PTRA
Sbjct: 327 LEVSDGIMMARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G FP++AVKM IA+ E +R+ F + R
Sbjct: 387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAP 446
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
L D T E A ++A I+ T+TGR+A+L+SR++P+ + + + +
Sbjct: 447 LSRDPT-----EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQ 501
Query: 415 VCNNLMFSYGVYAFCLEE 432
+ S GV+ E
Sbjct: 502 AARQVHLSRGVFPLLYRE 519
>pdb|1PKL|G Chain G, The Structure Of Leishmania Pyruvate Kinase
>gi|3660264|pdb|1PKL|D Chain D, The Structure Of
Leishmania Pyruvate Kinase >gi|3660265|pdb|1PKL|E Chain
E, The Structure Of Leishmania Pyruvate Kinase
>gi|3660263|pdb|1PKL|C Chain C, The Structure Of
Leishmania Pyruvate Kinase >gi|3660267|pdb|1PKL|H Chain
H, The Structure Of Leishmania Pyruvate Kinase
>gi|3660261|pdb|1PKL|A Chain A, The Structure Of
Leishmania Pyruvate Kinase >gi|3660266|pdb|1PKL|F Chain
F, The Structure Of Leishmania Pyruvate Kinase
>gi|3660262|pdb|1PKL|B Chain B, The Structure Of
Leishmania Pyruvate Kinase
Length = 499
Score = 287 bits (726), Expect = 2e-76
Identities = 170/455 (37%), Positives = 258/455 (56%), Gaps = 17/455 (3%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
+I+ TIGP+T S +K LI++G+SV R+NFSHGS E H I VR + +L +AI
Sbjct: 23 RIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIA 82
Query: 72 ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDVI 128
D G +IR G+ GG ++RG +TT D+ T ++Y++ ++V G+ I
Sbjct: 83 LDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYI 142
Query: 129 YLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
Y+ DG ++L+V+ Q +E V + + R+G+N+P + + AV+ +D ++F +
Sbjct: 143 YIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGV 202
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD I SF+ S V V+ L D+ +I KIE V+N D I++ SDGIM+
Sbjct: 203 EQGVDMIFASFIRSAEQVGDVRKALGPK-GRDIMIICKIENHQGVQNIDSIIEESDGIMV 261
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E++ + QK LI K N GKPVI ATQML SMT PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAV 321
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIA----KVTEEYRESFGMSRLRELVEDGTRGT 363
+G D VMLS ETA GK+P + V+ MA+I EY + +L+ + +
Sbjct: 322 FNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPM-----S 376
Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
EA+ S ++++ K ++ + TGR+ARL+++++P I +T + C L +
Sbjct: 377 ADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 436
Query: 424 GVYAFCLEE---GFDERDIIRLIKGLGLVESDDIV 455
GV + + G DE R+ G+ +S V
Sbjct: 437 GVESVFFDADKLGHDEGKEHRVAAGVEFAKSKGYV 471
>gi|6755074 pyruvate kinase 3 [Mus musculus] >gi|1405933|emb|CAA65761.1|
(X97047) M2-type pyruvate kinase [Mus musculus]
Length = 531
Score = 286 bits (725), Expect = 3e-76
Identities = 171/432 (39%), Positives = 262/432 (60%), Gaps = 22/432 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S M+K++I++G++V RLNFSHG+ E HA+ I+ VR+ ++ L
Sbjct: 45 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V+E + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI +TQML M + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICSTQMLEIMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458
Query: 415 VCNNLMFSYGVY 426
G++
Sbjct: 459 TARQAHLYRGIF 470
>sp|P52480|KPY2_MOUSE PYRUVATE KINASE, M2 ISOZYME
Length = 531
Score = 286 bits (725), Expect = 3e-76
Identities = 171/432 (39%), Positives = 262/432 (60%), Gaps = 22/432 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S M+K++I++G++V RLNFSHG+ E HA+ I+ VR+ ++ L
Sbjct: 45 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V+E + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI +TQML M + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICSTQMLEIMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458
Query: 415 VCNNLMFSYGVY 426
G++
Sbjct: 459 TARQAHLYRGIF 470
>pir||A54113 pyruvate kinase (EC 2.7.1.40) - rabbit
Length = 530
Score = 286 bits (724), Expect = 4e-76
Identities = 172/473 (36%), Positives = 274/473 (57%), Gaps = 26/473 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V R+NFSHG+ E HA+ I+ VR ++ L
Sbjct: 44 TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +++ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 224 DIQDLKFGVDEDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E F EL
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE--AAMFHRKLFEELARS 400
Query: 359 GTRGT-IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCN 417
+ T + EA+A ++A ++ T +GR+A ++R++P+ I + N +
Sbjct: 401 SSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTAR 460
Query: 418 NLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 461 QAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513
>pir||A33983 pyruvate kinase (EC 2.7.1.40) isozyme M2 - human
>gi|338827|gb|AAA36672.1| (M26252) cytosolic thyroid
hormone-binding protein (EC 2.7.1.40) [Homo sapiens]
Length = 531
Score = 286 bits (723), Expect = 5e-76
Identities = 177/476 (37%), Positives = 277/476 (58%), Gaps = 32/476 (6%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V RLNFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPYL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG +ELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAELELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458
Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 459 TARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG 514
>pir||S55921 pyruvate kinase (EC 2.7.1.40) isozyme M2 - mouse
>gi|551295|dbj|BAA07457.1| (D38379) pyruvate kinase M
[Mus musculus] >gi|1098063|prf||2115223A pyruvate kinase
M2 [Mus musculus]
Length = 531
Score = 286 bits (723), Expect = 5e-76
Identities = 171/432 (39%), Positives = 261/432 (59%), Gaps = 22/432 (5%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S M+K++I++G++V RLNFSHG+ E HA+ I+ VR+ ++ L
Sbjct: 45 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILRLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G IY+ DG I L+V+E + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG E+P E++ + QK +I + N GKPVI +TQML M + PTRA
Sbjct: 284 LEASDGIMVARGDLGTEIPAEKVFLSQKMMIGRCNRAGKPVICSTQMLEIMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQ 458
Query: 415 VCNNLMFSYGVY 426
G++
Sbjct: 459 TARQAHLYRGIF 470
>pir||G82011 pyruvate kinase (EC 2.7.1.40) NMA0177 [imported] - Neisseria
meningitidis (group A strain Z2491)
>gi|7378949|emb|CAB83492.1| (AL162752) pyruvate kinase
[Neisseria meningitidis Z2491]
Length = 490
Score = 285 bits (722), Expect = 7e-76
Identities = 177/479 (36%), Positives = 271/479 (55%), Gaps = 12/479 (2%)
Query: 9 HKTKIVATIGPATSSRNMIKKLIE-NGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRR 67
H TKIVAT+GP +++ +++ +I G++VVR NFSHG+ E H + VR+ +++ +
Sbjct: 13 HNTKIVATLGPGSNNVELLEDMIRVGGLNVVRFNFSHGTPEFHQENARIVREAAKRTGQE 72
Query: 68 VAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGD 126
+AI+ADL G KIRVG+I GG +EL +GE + L + G + ++Y+D P V+ GD
Sbjct: 73 IAIIADLQGPKIRVGKIAGGGIELNKGETLGLDAALEGEGTREAVGLDYRDLPDDVAAGD 132
Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFA 186
V++L DG + L VE V G + V + L S KGIN L A+T +D +K A
Sbjct: 133 VLWLDDGLLTLTVESVEGSRIITRVENSHVLKSNKGINKRGGGLSAGALTEKDFRDLKTA 192
Query: 187 IEQGVDAIGLSFVGSVYDV----LKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
I G D + +SFV S D+ KV+ ++ + A ++SKIER +A+ N DEI+ A
Sbjct: 193 IAIGCDYLAISFVKSAEDLHIARAKVEEEMKGSTAVRPGLVSKIERVEAIENLDEIILAG 252
Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
DGIM+ARGDL VE+ +P LQK +IR+A + ITATQM+ SM VPTRAEV+D
Sbjct: 253 DGIMVARGDLAVEVGHAAVPALQKRMIRRARELRRFSITATQMMESMITNPVPTRAEVSD 312
Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
VANA+LDGTDAVM S ETA+G +P + V MA I E+ ++S ++ + E VE
Sbjct: 313 VANAVLDGTDAVMCSAETAVGAYPFETVSQMAIICAAAEKEQDS--LNGVAEQVEYPEAV 370
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
+ A+A + ++ K I+ T +G TA ISR IF + + +
Sbjct: 371 STNLAVAGGAVSVARAVHAKAIVALTESGSTAFEISRHNITLPIFALTPSVSAQRRMAMY 430
Query: 423 YGVYAFCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
GV L D + ++ + ++ S D ++T G + ++ TN++++ ++
Sbjct: 431 RGVRPLILATSTDHDTALNEVETMLVEHNILHSGDQYIITSGSQMRESGSTNTLEVLRV 489
>sp|P30614|KPYK_YARLI PYRUVATE KINASE >gi|424047|gb|AAA18520.1| (M86863) pyruvate kinase
[Yarrowia lipolytica]
Length = 542
Score = 284 bits (720), Expect = 1e-75
Identities = 179/473 (37%), Positives = 267/473 (55%), Gaps = 27/473 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
K+ I+ TIGP T+S MI KL + G+++VR+NFSHGS+E H VIE R+ Q+ R +
Sbjct: 31 KSSIIGTIGPNTNSAEMISKLRQAGLNIVRMNFSHGSYEYHQSVIENARESEQRFRGRPL 90
Query: 69 AILADLPGLKIRVGEIKGGYV-ELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSK--- 124
AI D G +IR G K ++K G ++ +T D+ + Y D+ +V +
Sbjct: 91 AIALDTKGPEIRTGVTKDDKDWDVKAGHVMLFSTNPKYKDQCDDKIMYIDYTNIVKQIDI 150
Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G +I++ DG + +V E++ G+ ++ ++ GK+ SRKG+N+P + + A++ +D +
Sbjct: 151 GKIIFVDDGVLSFKVLEKIDGETLKVETLNNGKISSRKGVNLPGTDVDLPALSEKDKADL 210
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
KF +E GVD I SFV + DV ++ L + + + VISKIE V NFDEILK +D
Sbjct: 211 KFGVEHGVDMIFASFVRTANDVQAIRDVLGEK-GKGIQVISKIENQQGVNNFDEILKETD 269
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P ++ I QK+LI K N GKPVI ATQML SMT PTRAEV+DV
Sbjct: 270 GVMVARGDLGIEIPAPQVFIAQKQLIAKCNLAGKPVICATQMLDSMTYNPRPTRAEVSDV 329
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGT 360
NA+LDG D VMLS ETA G +PI++VKMM + V E+ Y F + +R L T
Sbjct: 330 GNAVLDGADCVMLSGETAKGTYPIESVKMMHETCLVAEKAIAYAPLF--NEMRTLTVRPT 387
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
E IA S + A + I+ + +G +ARL S+++P I + N +
Sbjct: 388 ETV--ETIAISAVSASFEQQARAIIVLSTSGTSARLCSKYRPNCPILMVTRNAQAARFSH 445
Query: 421 FSYGVYAFCLEEGFD------ERDIIRLIK-------GLGLVESDDIVLMTEG 460
GVY F + + D+ +K LG++ D+V+ +G
Sbjct: 446 LYRGVYPFIYHKARASNPAEWQHDVEERLKWGMDEAVALGILNKGDVVVAIQG 498
>gb|AAB86587.1| (AF032389) pyruvate kinase; ATP:pyruvate 2-o-phosphotransferase
[Oryctolagus cuniculus]
Length = 530
Score = 284 bits (720), Expect = 1e-75
Identities = 176/476 (36%), Positives = 277/476 (57%), Gaps = 32/476 (6%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V R+NFSHG+ E HA+ I+ VR ++ L
Sbjct: 44 TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 103
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 104 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 163
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 164 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 223
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 224 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 282
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 283 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 342
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 343 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 402
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 403 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNHQ 457
Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 458 TARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 513
>sp|O18919|KPY2_RABIT PYRUVATE KINASE, M2 ISOZYME
Length = 531
Score = 284 bits (720), Expect = 1e-75
Identities = 176/476 (36%), Positives = 277/476 (57%), Gaps = 32/476 (6%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK------L 64
T I+ TIGPA+ S +K++I++G++V R+NFSHG+ E HA+ I+ VR ++ L
Sbjct: 45 TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 104
Query: 65 DRRVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVG---DETTIPVEYKDF 118
R VA+ D G +IR G IKG VELK+G + +T + DE + ++YK+
Sbjct: 105 YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164
Query: 119 PRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPR 178
++V G +Y+ DG I L+V++ + V +GG L S+KG+N+P A + + AV+ +
Sbjct: 165 CKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEK 224
Query: 179 DMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEI 238
D++ +KF +EQ VD + SF+ DV +V+ L + +++ +ISKIE + VR FDEI
Sbjct: 225 DIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK-GKNIKIISKIENHEGVRRFDEI 283
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
L+ASDGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRA
Sbjct: 284 LEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRA 343
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESF-GMSRLRE 354
E +DVANA+LDG D +MLS ETA G +P++AV+M IA+ E + + F + RL
Sbjct: 344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
+ D T EA A ++A I+ T++GR+A ++R++P+ I + N +
Sbjct: 404 ITSDPT-----EAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNHQ 458
Query: 415 VCNNLMFSYGVYAFCLEEGFDE---RDI-------IRLIKGLGLVESDDIVLMTEG 460
G++ ++ E D+ + + K G + D+V++ G
Sbjct: 459 TARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG 514
>sp|Q27686|KPYK_LEIME PYRUVATE KINASE (PK) >gi|577072|emb|CAA52898.1| (X74944) pyruvate
kinase [Leishmania mexicana]
Length = 499
Score = 283 bits (717), Expect = 3e-75
Identities = 169/455 (37%), Positives = 256/455 (56%), Gaps = 17/455 (3%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
+I+ TIGP+T S +K LI++G+SV R+NFSHGS E H I VR + +L +AI
Sbjct: 23 RIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIA 82
Query: 72 ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDVI 128
D G +IR G+ GG ++RG +TT D+ T ++Y++ ++V G+ I
Sbjct: 83 LDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYI 142
Query: 129 YLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
Y+ DG ++L+V+ Q +E V + + R+G+N+P + + AV+ +D ++F +
Sbjct: 143 YIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGV 202
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD I SF+ S V V+ L D+ +I KIE V+N D I++ SDGIM+
Sbjct: 203 EQGVDMIFASFIRSAEQVGDVRKALGPK-GRDIMIICKIENHQGVQNIDSIIEESDGIMV 261
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E++ + QK LI K N GKPVI ATQML SMT PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAV 321
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIA----KVTEEYRESFGMSRLRELVEDGTRGT 363
+G D VMLS ETA GK+P + V+ MA+I EY + +L+ + +
Sbjct: 322 FNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPM-----S 376
Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
EA+ S ++++ K ++ + TG ARL+++++P I +T + C L +
Sbjct: 377 ADEAVCGSAVNSVSETKAKAMVVLSNTGAGARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 436
Query: 424 GVYAFCLEE---GFDERDIIRLIKGLGLVESDDIV 455
GV + + G DE R+ G+ +S V
Sbjct: 437 GVESVFFDADKLGHDEGKEHRVAAGVEFAKSKGYV 471
>sp|Q40546|KPYG_TOBAC PYRUVATE KINASE ISOZYME G, CHLOROPLAST PRECURSOR
>gi|629696|pir||S44287 pyruvate kinase, plastid - common
tobacco >gi|482938|emb|CAA82223.1| (Z28374) Pyruvate
kinase; plastid isozyme [Nicotiana tabacum]
Length = 562
Score = 282 bits (714), Expect = 6e-75
Identities = 173/475 (36%), Positives = 267/475 (55%), Gaps = 13/475 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRV 68
KTKIV TIGP+TSSR MI KL E G++V RLN SHG H + I+ V++ + + D+ +
Sbjct: 92 KTKIVCTIGPSTSSREMIWKLAEAGMNVARLNMSHGDHASHQRTIDLVKEYNAQFEDKVI 151
Query: 69 AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
AI+ D G ++ G++ + LK G++ + + V E T+ V Y DF V GD++
Sbjct: 152 AIMLDTKGPEVISGDVPKPIL-LKEGQEFNFSIKRGVSTEDTVSVNYDDFINDVEAGDIL 210
Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
+ G + L V+ V+ V+ GG+L SR+ +N+ + ++T +D + IKF +
Sbjct: 211 LVDGGMMSLAVKSKTSDIVKCEVIDGGELKSRRHLNVRGKSATLPSITEKDWDDIKFGVN 270
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
VD +SFV V ++K +L+ +A D+ VI KIE D++ N I+ ASDG M+A
Sbjct: 271 NQVDFYAVSFVKDAKVVHELKDYLKSCNA-DIHVIVKIESADSIPNLHSIISASDGAMVA 329
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLG E+PIE +P+LQ+++IR+ + KPVI AT ML SM PTRAEV+D++ A+
Sbjct: 330 RGDLGAELPIEEVPLLQEDIIRRCQSMQKPVIVATNMLESMIDHPTPTRAEVSDISIAVR 389
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
+G DAVMLS ETA GK+P+ AVK+M +A TE + S + G +
Sbjct: 390 EGADAVMLSGETAHGKYPLKAVKVMHIVALRTESSLQKSTSSPSQSAAYKSHMGEMFAFH 449
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
+ S+ + L T I+ TRTG A ++S +P +F F+ NERV L +GV
Sbjct: 450 SSSMANTLST----PIIVFTRTGSMAIILSHNRPSSTVFAFTNNERVKQRLALYHGVVPI 505
Query: 429 CLEEGFDERD----IIRLIKGLGLVESDDIVLMTE--GKPIEKTMGTNSIKIFQI 477
+E D + I+L+ LV+ V + + +PI + T+ I++ ++
Sbjct: 506 YMEFSSDAEETFSRAIKLLLSKSLVKDGQYVTLVQSGAQPIWRRHSTHHIQVRKV 560
>pir||E82757 pyruvate kinase type II XF0824 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9105726|gb|AAF83634.1|AE003922_4
(AE003922) pyruvate kinase type II [Xylella fastidiosa]
Length = 501
Score = 282 bits (714), Expect = 6e-75
Identities = 177/478 (37%), Positives = 271/478 (56%), Gaps = 18/478 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+T+I+AT+GPAT ++ L + GV+VVRLNFSHG + A+ +VR + + +
Sbjct: 20 RTRILATLGPATDPPGVLDALFKAGVNVVRLNFSHGDASDQARRAAEVRAAAAHVGVEIG 79
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEK--VVLTTRDVVGDETTIPVEYKDFPRLVSKGDV 127
ILADLPG KIR+G G V L + ++ + +GD T + V Y P+ V+ GDV
Sbjct: 80 ILADLPGPKIRIGRFTEGKVRLVADARFDLLADSNAPLGDATQVGVSYLGLPQDVAAGDV 139
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG + L+V +V+G + V++ G L RKG+N L + A+T RD E+I
Sbjct: 140 LLLDDGLMQLQVVQVQGARIVTTVLNDGVLSDRKGLNKQGGGLSLGALTDRDRELIGIVS 199
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
GVD I +SF ++ + + + D ++SKIER +A+ N EI+ ASD +M+
Sbjct: 200 RMGVDFIAVSFCRHAEEMHEARRIARECGC-DAALVSKIERAEAIVNLAEIVAASDVVMV 258
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+ +LP LQK++I++A + K VITATQML SM +PTRAEV DVANA+
Sbjct: 259 ARGDLGVEIGDAQLPGLQKKIIKEALLQNKVVITATQMLQSMVESPMPTRAEVLDVANAV 318
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE---EYRESFGMSRLRELVEDGTRGTI 364
+DGTDAVMLS ETA G +P+ AV+ MA+I E E+ + M++ D
Sbjct: 319 IDGTDAVMLSAETATGDYPVKAVEAMARICLGAEHQFEFDTDYEMAQRNLQRAD------ 372
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
AIA + + + + ++ T +G T R +SRF+ I+ F+ +E V ++ G
Sbjct: 373 -HAIAMATMFLSEHICLGGVVALTESGTTPRFLSRFRSHVPIYAFTRHEDVRRRMVLMRG 431
Query: 425 VYAFCLE-EGFDERD----IIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
V+ + G R+ IRL+ G + D V+ T G+ +E TN++++ ++
Sbjct: 432 VFPMRFDSRGLTPREAARATIRLLVECGCMSPGDRVVFTSGEHMETLGATNTLRLLEV 489
>dbj|BAB12236.1| (AB032276) pyruvate kinase [Aspergillus oryzae]
Length = 526
Score = 282 bits (713), Expect = 7e-75
Identities = 172/472 (36%), Positives = 269/472 (56%), Gaps = 24/472 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQ-KLDRRV 68
+T I+ TIGP T+S I L +G++VVR+NFSHGS+E H VI+ R+ ++ + R +
Sbjct: 34 RTSIIGTIGPKTNSVEKINALRRSGLNVVRMNFSHGSYEYHQSVIDNAREAARVQTGRPL 93
Query: 69 AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDV---VGDETTIPVEYKDFPRLVSK 124
AI D G +IR G + +K G ++ +TT + D+ + ++YK+ +++
Sbjct: 94 AIALDTKGPEIRTGNTTDDKDIPIKEGHELNITTDEKYANASDDQNMYLDYKNITNVIAP 153
Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G +IY+ DG + +V E V + + ++ G + SRKG+N+P + + A++ +D+ +
Sbjct: 154 GKLIYVDDGILSFQVLEVVDDKTLRVKCLNNGNISSRKGVNLPGTDVDLPALSEKDISDL 213
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
KF ++ GVD I SF+ D+ ++ L + + +++ +I+KIE V NFDEIL+ +D
Sbjct: 214 KFGVKNGVDMIFASFIRRGSDIRHIRDVLGE-EGKEIQIIAKIENQQGVNNFDEILEETD 272
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P ++ I QK +I K N +GKPVI ATQML SMT PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
ANA+LDG D VMLS ETA G +P +AVKMM++ + E F + LR L T
Sbjct: 333 ANAVLDGADCVMLSGETAKGSYPCEAVKMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
E+IA + + A LN I+ T +G TARL+S+++P I + N R
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGNTARLLSKYRPVCPILMVTRNPRASRYSHLY 450
Query: 423 YGVYAFCLEEG-------FDERDIIRLIK-------GLGLVESDDIVLMTEG 460
GV+ F E + D+ R +K LG++ D ++ +G
Sbjct: 451 RGVWPFLFPENKPDFNVKIWQEDVDRRLKWAISHGIKLGIINKGDNIVCVQG 502
>sp|O51323|KPYK_BORBU PYRUVATE KINASE (PK) >gi|7434449|pir||C70143 pyruvate kinase (pyk)
homolog - Lyme disease spirochete
>gi|2688255|gb|AAC66733.1| (AE001141) pyruvate kinase
(pyk) [Borrelia burgdorferi]
Length = 477
Score = 279 bits (707), Expect = 4e-74
Identities = 178/473 (37%), Positives = 271/473 (56%), Gaps = 22/473 (4%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
TKIVATI IK L + GV+V+RLN +H S E+ KVI+ VR IS K +A+
Sbjct: 6 TKIVATISDLRCEPEHIKDLHDAGVNVIRLNTAHQSHEDTIKVIDNVRKISNK----IAL 61
Query: 71 LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYL 130
+ D G ++R I+ + +K G+KV+++T + + Y F + V +G + +
Sbjct: 62 MIDTKGPEVRTANIENPII-VKTGDKVIISTSPI-NEPNNFQTNYDGFVKEVPQGSKVLI 119
Query: 131 SDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQG 190
DG + + V + + + G++ ++K IN P L +++VT +D I+ A +
Sbjct: 120 DDGELEMTVVAKLPDRLICEIKNDGQIKNKKSINTPGISLKLQSVTEKDKGFIELAAKYN 179
Query: 191 VDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARG 250
VD I SFV DV V+ L + DV +ISKIE + + N +EI KAS GIM+ARG
Sbjct: 180 VDFIAHSFVRHSKDVQDVQEILTASGNPDVKIISKIENQEGIDNIEEIAKASYGIMVARG 239
Query: 251 DLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDG 310
D+GVE+P E +PI Q ++ + G PVITATQML +M PTRAEV+D+ANAIL+G
Sbjct: 240 DMGVEIPAEDVPIAQLKITQTCIKYGIPVITATQMLHTMIENPRPTRAEVSDIANAILNG 299
Query: 311 TDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLR-ELVEDGTRGTIKEAIA 369
TDA+MLS ETA GK+PI+AVKMM IAK E++R+ M+ + EL D + + I
Sbjct: 300 TDAIMLSGETAYGKYPIEAVKMMTSIAKKVEKHRK---MTLYKDELFYD--KSITRNYII 354
Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
+ IDA ++IK I+ + G+TAR+++ ++ +F + +ER+ L SYGVY+
Sbjct: 355 KCAIDATKLMDIKAIIVDSLKGKTARIMATYRASVPLFITTNSERLARELALSYGVYSNL 414
Query: 430 LEEGFDER-----DIIRLIKGLGLVESDDIVLMTEGKP---IEKTMGTNSIKI 474
++ F ++++K G+V D V++ G P IEK GT ++I
Sbjct: 415 VDNNFKRTTEFVVTSLKMLKEQGVVNDKDTVIIISGNPNRNIEK--GTEFMEI 465
>sp|Q57572|KPYK_METJA PYRUVATE KINASE (PK) >gi|2129228|pir||D64313 pyruvate kinase (EC
2.7.1.40) - Methanococcus jannaschii
>gi|1590885|gb|AAB98090.1| (U67468) pyruvate kinase
[Methanococcus jannaschii]
Length = 447
Score = 279 bits (705), Expect = 6e-74
Identities = 189/471 (40%), Positives = 271/471 (57%), Gaps = 33/471 (7%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKI+ T+GP S N + K I N + VR N SH + + EK +I +K +A
Sbjct: 7 KTKILVTLGP--SLENKLDKAI-NLIDGVRFNMSHATTD----YCEKFLNILEK--NNIA 57
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
+ DL G+KIR+ E+K LK GEKVV +G++ + + +G I
Sbjct: 58 KVMDLKGIKIRIKEVKLKNKILKMGEKVV------IGEDIKLNYNIDT----IEEGHFIL 107
Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
++DG I LRV E + + AVV GG++ G+N+P + + + D++ IKFA+E+
Sbjct: 108 INDGKIKLRVVE-KTDKIIAVVEVGGEIKEGMGVNLPDTRIELPIIDETDLKNIKFAVEK 166
Query: 190 GVDAIGLSFVGSVYDVLKVKSFLE--KNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
+ I LSFV + DV ++K + K D E VISKIE + ++N EI + SDG+M+
Sbjct: 167 DFEYIALSFVRNKEDVKELKDIISEYKGDCE---VISKIETKEGLKNIKEIARESDGVMV 223
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+PIE +PI QK ++R AN G ITATQ+L SM PTRAEVTD+ANAI
Sbjct: 224 ARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAI 283
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
DGTD +MLS ET IGK+PI+A+K++ K+AKV +E+ E FG R+ VE +I E
Sbjct: 284 YDGTDCLMLSNETTIGKYPIEAIKVLNKVAKVADEHYEEFG-DRVCLEVE-----SIDEG 337
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
+ ++ + LN K ++TPT +GRTA+LIS+ + I + N R L +GV +
Sbjct: 338 LVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVES 397
Query: 428 FCLEEGFDERDIIRLIKGLGLVE-SDDIVLMTEGKPIEKTMGTNSIKIFQI 477
+EE D II + + E I L+T G PI + TN+IK+ I
Sbjct: 398 CLMEEFDDMEKIINTCREMAKKEIGKGIYLITLGHPIGQKK-TNTIKVESI 447
>sp|P22360|KPYK_EMENI PYRUVATE KINASE (PK) >gi|283342|pir||S27364 pyruvate kinase (EC
2.7.1.40) - Emericella nidulans
>gi|168074|gb|AAA33320.1| (M36918) pyruvate kinase
[Aspergillus nidulans]
Length = 526
Score = 277 bits (701), Expect = 2e-73
Identities = 174/472 (36%), Positives = 265/472 (55%), Gaps = 24/472 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDIS-QKLDRRV 68
+T I+ TIGP T+S I L G++VVR+NFSHGS+E H VI+ R+ Q R V
Sbjct: 34 RTSIICTIGPKTNSVEKINALRRAGLNVVRMNFSHGSYEYHQSVIDHAREAEKQAAGRPV 93
Query: 69 AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRD---VVGDETTIPVEYKDFPRLVSK 124
AI D G +IR G G + +K G ++ ++T + D+ + V+YK+ +++S
Sbjct: 94 AIALDTKGPEIRTGNTVGDKDIPIKAGHEMNISTDEQYATASDDQNMYVDYKNITKVISA 153
Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G +IY+ DG + V E V + + ++ G + SRKG+N+P + + A++ +D+ +
Sbjct: 154 GKLIYVDDGILSFEVLEVVDDKTLRVRCLNNGNISSRKGVNLPGTDVDLPALSEKDISDL 213
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
KF ++ VD + SF+ D+ ++ L + + ++ +I+KIE V NFDEIL+ +D
Sbjct: 214 KFGVKNKVDMVFASFIRRGSDIRHIREVLGE-EGREIQIIAKIENQQGVNNFDEILEETD 272
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P ++ I QK +I K N +GKPVI ATQML SMT PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
ANA+LDG D VMLS ETA G +P +AV MM++ + E F + LR L T
Sbjct: 333 ANAVLDGADCVMLSGETAKGNYPCEAVTMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
E+IA + + A LN I+ T +G TAR+IS+++P I S N
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGNTARMISKYRPVCPIIMVSRNPAATRYSHLY 450
Query: 423 YGVYAFCLEE---GFD----ERDIIRLIK-------GLGLVESDDIVLMTEG 460
GV+ F E F+ + D+ R +K LG++ D ++ +G
Sbjct: 451 RGVWPFYFPEKKPDFNVKIWQEDVDRRLKWGINHGLKLGIINKGDNIVCVQG 502
>gb|AAK41255.1| Pyruvate kinase (pyK) [Sulfolobus solfataricus]
Length = 452
Score = 276 bits (699), Expect = 3e-73
Identities = 164/431 (38%), Positives = 254/431 (58%), Gaps = 28/431 (6%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIVAT+GP SS +K+L E V V R+NF+HG H K + +R + + +
Sbjct: 3 KTKIVATLGP--SSEEKVKELAEY-VDVFRINFAHGDETSHRKYFDLIRTYAPES----S 55
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
I+ DLPG K+R+GE+K +E+K+G+K+V + +D IPV+ + F V + I
Sbjct: 56 IIVDLPGPKLRLGELKEP-IEVKKGDKIVFSQKD------GIPVDDELFYSAVKENSDIL 108
Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
++DG I +RV+ VE V+ GG L SRKGINIP L +T D++++K A++
Sbjct: 109 IADGTIRVRVKSKAKDRVEGTVIEGGILLSRKGINIPNVNLK-SGITDNDLKLLKRALDL 167
Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
G D IGLSFV S DV KVK F+ ++ +VI+KIE+ +A++N I+ SDGIM+AR
Sbjct: 168 GADYIGLSFVISENDVKKVKEFV----GDEAWVIAKIEKSEALKNLTNIVNESDGIMVAR 223
Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
GDLGVE +E LP++Q+ ++R + GKPVI ATQ+L SM +PTRAE+ D++N+I+
Sbjct: 224 GDLGVETGLENLPLIQRRIVRTSRVFGKPVILATQVLTSMINSPIPTRAEIIDISNSIMQ 283
Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
G D++MLS+ETAIG +P+++V+ + I E+ + + G + +AIA
Sbjct: 284 GVDSIMLSDETAIGNYPVESVRTLHNIISNVEKSVKHRPI---------GPLNSESDAIA 334
Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
+ ++A I+ +R+G + +SR +P++ I G S + R+ YGV
Sbjct: 335 LAAVNASKVSKADVIVVYSRSGNSILRVSRLRPERNIIGVSPDPRLAKKFKLCYGVIPIS 394
Query: 430 LEEGFDERDII 440
+ + D I
Sbjct: 395 INKKMQSIDEI 405
>pir||S26869 pyruvate kinase (EC 2.7.1.40) pkiA - Aspergillus niger
Length = 526
Score = 275 bits (696), Expect = 7e-73
Identities = 170/472 (36%), Positives = 269/472 (56%), Gaps = 24/472 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQ-KLDRRV 68
+T I+ TIGP T+S I L G++VVR+NFSHGS+E H VI+ R+ ++ ++ R +
Sbjct: 34 RTSIIGTIGPKTNSVEKINSLRTAGLNVVRMNFSHGSYEYHQSVIDNAREAAKTQVGRPL 93
Query: 69 AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRD---VVGDETTIPVEYKDFPRLVSK 124
AI D G +IR G + +K+G ++ +TT + D+ + ++YK+ +++S
Sbjct: 94 AIALDTKGPEIRTGNTPDDKDIPIKQGHELNITTDEQYATASDDKNMYLDYKNITKVISP 153
Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G +IY+ DG + V E V + + ++ G + SRKG+N+P + + A++ +D+ +
Sbjct: 154 GKLIYVDDGILSFEVLEVVDDKTIRVRCLNNGNISSRKGVNLPGTDVDLPALSEKDIADL 213
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
KF + VD + SF+ D+ ++ L + + +++ +I+KIE V NFDEIL+ +D
Sbjct: 214 KFGVRNKVDMVFASFIRRGSDIRHIREVLGE-EGKEIQIIAKIENQQGVNNFDEILEETD 272
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P ++ I QK +I K N +GKPVI ATQML SMT PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
ANA+LDG D VMLS ETA G +P +AVKMM++ + E F + LR L T
Sbjct: 333 ANAVLDGADCVMLSGETAKGNYPNEAVKMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
E+IA + + A LN I+ T +G+TAR +S+++P I + N
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGKTARYLSKYRPVCPIVMVTRNPAASRYSHLY 450
Query: 423 YGVYAFCLEE---GFD----ERDIIRLIK-------GLGLVESDDIVLMTEG 460
GV+ F E F+ + D+ R +K LG++ D ++ +G
Sbjct: 451 RGVWPFLFPEKKPDFNVKVWQEDVDRRLKWGINHALKLGIINKGDNIVCVQG 502
>sp|Q12669|KPYK_ASPNG PYRUVATE KINASE (PK) >gi|250607|gb|AAB22392.1| (S38698) pyruvate
kinase {EC 2.7.1.40} [Aspergillus niger, N402, Peptide,
526 aa]
Length = 526
Score = 274 bits (693), Expect = 2e-72
Identities = 169/472 (35%), Positives = 269/472 (56%), Gaps = 24/472 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQ-KLDRRV 68
+T I+ TIGP T+S I L G++VVR+NFSHGS++ H VI+ R+ ++ ++ R +
Sbjct: 34 RTSIIGTIGPKTNSVEKINSLRTAGLNVVRMNFSHGSYQYHQSVIDNAREAAKTQVGRPL 93
Query: 69 AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRD---VVGDETTIPVEYKDFPRLVSK 124
AI D G +IR G + +K+G ++ +TT + D+ + ++YK+ +++S
Sbjct: 94 AIALDTKGPEIRTGNTPDDKDIPIKQGHELNITTDEQYATASDDKNMYLDYKNITKVISP 153
Query: 125 GDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G +IY+ DG + V E V + + ++ G + SRKG+N+P + + A++ +D+ +
Sbjct: 154 GKLIYVDDGILSFEVLEVVDDKTIRVRCLNNGNISSRKGVNLPGTDVDLPALSEKDIADL 213
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
KF + VD + SF+ D+ ++ L + + +++ +I+KIE V NFDEIL+ +D
Sbjct: 214 KFGVRNKVDMVFASFIRRGSDIRHIREVLGE-EGKEIQIIAKIENQQGVNNFDEILEETD 272
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P ++ I QK +I K N +GKPVI ATQML SMT PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPAPKVFIAQKMMIAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDV 332
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
ANA+LDG D VMLS ETA G +P +AVKMM++ + E F + LR L T
Sbjct: 333 ANAVLDGADCVMLSGETAKGNYPNEAVKMMSETCLLAEVAIPHFNVFDELRNLAPRPT-- 390
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
E+IA + + A LN I+ T +G+TAR +S+++P I + N
Sbjct: 391 DTVESIAMAAVSASLELNAGAIVVLTTSGKTARYLSKYRPVCPIVMVTRNPAASRYSHLY 450
Query: 423 YGVYAFCLEE---GFD----ERDIIRLIK-------GLGLVESDDIVLMTEG 460
GV+ F E F+ + D+ R +K LG++ D ++ +G
Sbjct: 451 RGVWPFLFPEKKPDFNVKVWQEDVDRRLKWGINHALKLGIINKGDNIVCVQG 502
>dbj|BAB10461.1| (AB005234) pyruvate kinase [Arabidopsis thaliana]
Length = 510
Score = 274 bits (693), Expect = 2e-72
Identities = 163/402 (40%), Positives = 242/402 (59%), Gaps = 15/402 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S MI+KL++ G++V R NFSHGS E H + ++ +R Q A
Sbjct: 21 KTKIVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGILAA 80
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G ++LK G+++ +TT D+ GDE TI + YK P V G+
Sbjct: 81 VMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIKGDEKTISMSYKKLPVDVKPGNT 140
Query: 128 IYLSDGYIVLRVE--EVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-IIK 184
I +DG I L V + V + L RK +N+P + + +T +D+E I+K
Sbjct: 141 ILCADGSISLAVVSCDPNAGTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVEDILK 200
Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
+ + +D I LSFV D++ V+ L + ++ + ++SK+E + V NFDEIL+ +D
Sbjct: 201 WGVPNNIDMIALSFVRKGSDLVNVRKVLGSH-SKSIMLMSKVENQEGVLNFDEILRETDA 259
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
M+ARGDLG+E+PIE++ + QK +I K N GKPV+TATQML SM PTRAE TDVA
Sbjct: 260 FMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVA 319
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVE-DGT 360
NA+LDGTD VMLS E+A G +P AVK MAKI A+ + +Y F +E++
Sbjct: 320 NAVLDGTDCVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIF-----KEMIRATPL 374
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S + K I+ TR G TA+L+++++P
Sbjct: 375 PMSTLESLASSAVRTANKAKAKLIIVLTRGGTTAKLVAKYRP 416
>sp|O65595|KPYC_ARATH PROBABLE PYRUVATE KINASE, CYTOSOLIC ISOZYME (PK)
>gi|7434442|pir||T05065 pyruvate kinase (EC 2.7.1.40) -
Arabidopsis thaliana >gi|2982467|emb|CAA18231.1|
(AL022223) pyruvate kinase like protein [Arabidopsis
thaliana] >gi|7269491|emb|CAB79494.1| (AL161565)
pyruvate kinase like protein [Arabidopsis thaliana]
Length = 497
Score = 272 bits (689), Expect = 5e-72
Identities = 164/402 (40%), Positives = 246/402 (60%), Gaps = 15/402 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S M++KL+ G+SV R NFSHGS+E H + ++ +R A
Sbjct: 8 KTKIVCTLGPASRSVPMVEKLLMAGMSVARFNFSHGSYEYHQETLDNLRQAMLNTGMLCA 67
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G ++LK+G+++ ++T D+ GDE TI + YK + V+ G V
Sbjct: 68 VMLDTKGPEIRTGFLKDGKPIQLKQGQEITISTDYDLKGDEKTICMSYKKLAQDVNPGMV 127
Query: 128 IYLSDGYIVLRV---EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRD-MEII 183
I +DG I L+V ++ +G V + L RK +N+P + + +T +D +I+
Sbjct: 128 ILCADGTISLKVLSCDKEKGT-VRCRCENTSMLGERKNVNLPGVVVDLPTLTEKDKQDIL 186
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
++ + +D I LSFV D+++V+ L K+ A+ + ++SK+E + V NFD+IL SD
Sbjct: 187 EWGVPNQIDMIALSFVRKGSDLVQVRKLLGKH-AKTILLMSKVENQEGVANFDDILINSD 245
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
MIARGDLG+E+PIE++ + QK +I K N GKPV+TATQML SM PTRAE TDV
Sbjct: 246 AFMIARGDLGMEIPIEKIFLAQKVMIYKCNFMGKPVVTATQMLESMIKSPRPTRAEATDV 305
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVEDGT 360
ANA+LDGTD VMLS ETA G +P AV+ MAKI A+ T +Y + F L V
Sbjct: 306 ANAVLDGTDCVMLSGETAAGAYPELAVRTMAKICVEAESTLDYGDIFKRIMLHAAVPMSP 365
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
++ + R+ + TL ++ TR G TARL+++++P
Sbjct: 366 MESLASSAVRTATSSRATL----MMVLTRGGSTARLVAKYRP 403
>gb|AAF81342.1|AC007767_22 (AC007767) Strong similarity to a pyruvate kinase isozyme G,
chloroplast precursor from Nicotiana tabacum gb|Z28374.
It contains a pyruvate kinase domain PF|00224. EST
gb|AI996399 comes from this gene. [Arabidopsis thaliana]
Length = 567
Score = 272 bits (689), Expect = 5e-72
Identities = 173/475 (36%), Positives = 266/475 (55%), Gaps = 18/475 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQK-LDRRV 68
KTKIV TIGP++SSR MI KL E G++V RLN SHG H I+ V++ + +D+ +
Sbjct: 100 KTKIVCTIGPSSSSREMIWKLAEAGMNVARLNMSHGDHASHQITIDLVKEYNSLFVDKAI 159
Query: 69 AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
AI+ D G ++R G++ + L+ G++ T + V + T+ V Y DF V GD++
Sbjct: 160 AIMLDTKGPEVRSGDVPQP-IFLEEGQEFNFTIKRGVSLKDTVSVNYDDFVNDVEVGDIL 218
Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
+ G + L V+ V+ VV+ GG+L SR+ +N+ + ++T +D E IKF ++
Sbjct: 219 LVDGGMMSLAVKSKTSDLVKCVVIDGGELQSRRHLNVRGKSATLPSITDKDWEDIKFGVD 278
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
VD +SFV V ++K++L+ ++ VI KIE D+++N I+ A DG M+A
Sbjct: 279 NQVDFYAVSFVKDAKVVHELKNYLK-----NISVIVKIESADSIKNLPSIISACDGAMVA 333
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLG E+PIE +P+LQ+E+IR+ + KPVI AT ML SM PTRAEV+D+A A+
Sbjct: 334 RGDLGAELPIEEVPLLQEEIIRRCRSIHKPVIVATNMLESMINHPTPTRAEVSDIAIAVR 393
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
+G DA+MLS ETA GKFP+ AV +M +A TE S R G G +
Sbjct: 394 EGADAIMLSGETAHGKFPLKAVNVMHTVALRTEA-SLPVRTSASRTTAYKGHMGQMFAFH 452
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
A + + L + I + TRTG A L+S ++P IF F+ R+ L GV
Sbjct: 453 ASIMANTLSSPLIVF----TRTGSMAVLLSHYRPSATIFAFTNQRRIMQRLALYQGVMPI 508
Query: 429 CLEEGFDERDI----IRLIKGLGLV-ESDDIVLMTEG-KPIEKTMGTNSIKIFQI 477
+E D D ++L++ ++ E + L+ G +PI + T+ I++ +I
Sbjct: 509 YMEFSDDAEDTYARSLKLLQDENMLKEGQHVTLVQSGSQPIWREESTHLIQVRKI 563
>dbj|BAB10006.1| (AB006697) pyruvate kinase [Arabidopsis thaliana]
Length = 510
Score = 272 bits (688), Expect = 6e-72
Identities = 165/407 (40%), Positives = 243/407 (59%), Gaps = 17/407 (4%)
Query: 5 RLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL 64
R+P KTKIV T+GPA+ + +MI+KL++ G++V R NFSHGS E H + ++ +R
Sbjct: 18 RIP--KTKIVCTLGPASRTVSMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRSAMHNT 75
Query: 65 DRRVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLV 122
A++ D G +IR G +K G ++LK G+++ +TT D+ GDE+TI + YK P V
Sbjct: 76 GILAAVMLDTKGPEIRTGFLKDGNPIQLKEGQEITITTDYDIQGDESTISMSYKKLPLDV 135
Query: 123 SKGDVIYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
G+ I +DG I L V + V + L RK +N+P + + +T +D+
Sbjct: 136 KPGNTILCADGSISLAVLSCDPESGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTDKDI 195
Query: 181 E-IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEIL 239
E I+ + + +D I LSFV D++ V+ L + A+ + ++SK+E + V NFDEIL
Sbjct: 196 EDILGWGVPNSIDMIALSFVRKGSDLVNVRKVLGSH-AKSIMLMSKVENQEGVINFDEIL 254
Query: 240 KASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAE 299
+ +D M+ARGDLG+E+PIE++ + QK +I K N GKPV+TATQML SM PTRAE
Sbjct: 255 RETDAFMVARGDLGMEIPIEKIFLAQKLMIYKCNLAGKPVVTATQMLESMIKSPRPTRAE 314
Query: 300 VTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESF-GMSRLREL 355
TDVANA+LDGTD VMLS E+A G +P AVK+MAKI A+ + +Y F M R L
Sbjct: 315 ATDVANAVLDGTDCVMLSGESAAGAYPEIAVKVMAKICIEAESSLDYNTIFKEMIRATPL 374
Query: 356 VEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
E++A S + K I+ TR G TA L+++++P
Sbjct: 375 PMSPL-----ESLASSAVRTANKARAKLIIVLTRGGSTANLVAKYRP 416
>sp|O62619|KPYK_DROME PYRUVATE KINASE (PK) >gi|3108349|gb|AAC15808.1| (AF061507) pyruvate
kinase [Drosophila melanogaster]
>gi|3128475|gb|AAC16244.1| (AF062478) pyruvate kinase
[Drosophila melanogaster]
Length = 533
Score = 272 bits (687), Expect = 8e-72
Identities = 159/405 (39%), Positives = 244/405 (59%), Gaps = 19/405 (4%)
Query: 13 IVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVR----DISQKL--DR 66
IV TIGPA+SS M++K++ G+++ R+NFSHGS E HA + VR + S KL +
Sbjct: 50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEH 109
Query: 67 RVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
VAI D G +IR G I G +ELK+GEK+ LTT ++ ++ + Y D+ +V+
Sbjct: 110 PVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVN 169
Query: 124 ---KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
G+ ++++DG I L V EV + V +GG L SRKG+N+P + + AV+ +D
Sbjct: 170 VVKPGNRVFVNDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDK 229
Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
+ F +EQ VD I SF+ + + +++ L + +++ +ISKIE + N DEI++
Sbjct: 230 SDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEK-GKNIKIISKIENQQGMHNLDEIIE 288
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
A DGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRAE+
Sbjct: 289 AGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEI 348
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE--YRESFGMSRLRELVED 358
+DVANA+LDG D VMLS ETA G++P++ V MAK K E + ++F +LV
Sbjct: 349 SDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNF----FNDLVRG 404
Query: 359 GTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPK 403
A A + ++A I+ T +G++A +S+++P+
Sbjct: 405 AGTIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPR 449
>emb|CAA66194.1| (X97579) pyruvate kinase [Agaricus bisporus]
Length = 532
Score = 272 bits (687), Expect = 8e-72
Identities = 162/432 (37%), Positives = 245/432 (56%), Gaps = 14/432 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI--SQKLDRR 67
KT I+ATIGP ++ + + GV++VR+NFSHG+ E H VI+ R + + R
Sbjct: 34 KTAIIATIGPKINTVEKLTDVRLAGVNIVRMNFSHGTHEYHQSVIDNTRQMIKNDPHGRP 93
Query: 68 VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDV---VGDETTIPVEYKDFPRLVS 123
VAI D G +IR G+ + G +K G++ ++TT + D + V+Y + + +
Sbjct: 94 VAIALDTKGPEIRTGQTRDGNDYPIKAGDEFIVTTDPKYSDICDNKVLFVDYANLASVTA 153
Query: 124 KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G +IY+ DG I L + + G ++ ++ G L SRKG+N+PK + + ++ +D + +
Sbjct: 154 PGKLIYIDDGIISLLILSIDGMNLHVRALNNGTLSSRKGVNLPKTDVDLPPLSEKDKDDL 213
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
+F I GVD I SF+ DV +++ L D + +I KIE V NFDEILK +D
Sbjct: 214 RFGIRNGVDMIFASFIRRGEDVRQIREVLGP-DGASIKIIVKIENEQGVANFDEILKEAD 272
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P ++ + QK +I K N GKPVI ATQML SMT PTRAEV+DV
Sbjct: 273 GVMVARGDLGIEIPASQVFLAQKMMIAKCNIVGKPVIVATQMLESMTYNPRPTRAEVSDV 332
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGT 360
ANA+LDG+D VMLS ETA G +P+ +V MMA+ + E Y + R + T
Sbjct: 333 ANAVLDGSDCVMLSGETAKGSYPVQSVLMMAETCLLAETAICYPPLYDDLRAVQARPTET 392
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
E +A + + A + K +L + +G TARL+S+++PK I + NE+ +
Sbjct: 393 ----AETVAIAAVAAAAEQDAKALLVLSTSGETARLVSKYRPKIPIITVTRNEQTARQIH 448
Query: 421 FSYGVYAFCLEE 432
G Y F E
Sbjct: 449 LHRGCYPFWYPE 460
>emb|CAA62560.1| (X91106) pyruvate kinase [Agaricus bisporus]
Length = 530
Score = 272 bits (687), Expect = 8e-72
Identities = 162/432 (37%), Positives = 245/432 (56%), Gaps = 14/432 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDI--SQKLDRR 67
KT I+ATIGP ++ + + GV++VR+NFSHG+ E H VI+ R + + R
Sbjct: 32 KTAIIATIGPKINTVEKLTDVRLAGVNIVRMNFSHGTHEYHQSVIDNTRQMIKNDPHGRP 91
Query: 68 VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDV---VGDETTIPVEYKDFPRLVS 123
VAI D G +IR G+ + G +K G++ ++TT + D + V+Y + + +
Sbjct: 92 VAIALDTKGPEIRTGQTRDGNDYPIKAGDEFIVTTDPKYSDICDNKVLFVDYANLASVTA 151
Query: 124 KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G +IY+ DG I L + + G ++ ++ G L SRKG+N+PK + + ++ +D + +
Sbjct: 152 PGKLIYIDDGIISLLILSIDGMNLHVRALNNGTLSSRKGVNLPKTDVDLPPLSEKDKDDL 211
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
+F I GVD I SF+ DV +++ L D + +I KIE V NFDEILK +D
Sbjct: 212 RFGIRNGVDMIFASFIRRGEDVRQIREVLGP-DGASIKIIVKIENEQGVANFDEILKEAD 270
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P ++ + QK +I K N GKPVI ATQML SMT PTRAEV+DV
Sbjct: 271 GVMVARGDLGIEIPASQVFLAQKMMIAKCNIVGKPVIVATQMLESMTYNPRPTRAEVSDV 330
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGT 360
ANA+LDG+D VMLS ETA G +P+ +V MMA+ + E Y + R + T
Sbjct: 331 ANAVLDGSDCVMLSGETAKGSYPVQSVLMMAETCLLAETAICYPPLYDDLRAVQARPTET 390
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
E +A + + A + K +L + +G TARL+S+++PK I + NE+ +
Sbjct: 391 ----AETVAIAAVAAAAEQDAKALLVLSTSGETARLVSKYRPKIPIITVTRNEQTARQIH 446
Query: 421 FSYGVYAFCLEE 432
G Y F E
Sbjct: 447 LHRGCYPFWYPE 458
>gb|AAG18902.1| (AE004992) pyruvate kinase; PykA [Halobacterium sp. NRC-1]
Length = 579
Score = 272 bits (687), Expect = 8e-72
Identities = 174/476 (36%), Positives = 256/476 (53%), Gaps = 24/476 (5%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
KIV T+GPAT+ ++ L + G++V R+N SHG ++IE R + + D+ +A++
Sbjct: 5 KIVCTLGPATNDDASVRALADAGMTVARINASHGDAAARRELIETTRAVDAQTDKPLAVM 64
Query: 72 ADLPGLKIRVGEIKG-GYVELKRGEKVVLT-----TRDVVGDETTIPVEYKDFPRLVSKG 125
D G ++R I G + ++ G V T D +G T+I G
Sbjct: 65 LDTQGPEVRTAPIDDDGTIHIETGSDVAFVEGDTATPDRIGISTSIAA--------AEPG 116
Query: 126 DVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
D + L DG I V+ V G V A VVSGG L SRKG+N+P L V+ VT +D +
Sbjct: 117 DTVLLDDGRIEADVDRVAGDTVHATVVSGGSLGSRKGVNVPGVELDVDVVTEKDRRDLAL 176
Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGI 245
A E VD + SFV DVL V LE + A D+ +++KIER AV N D I+ A+ G+
Sbjct: 177 AAELDVDYVAASFVRDADDVLAVNRVLESHGA-DIPIVAKIERAGAVENLDGIIDAAQGV 235
Query: 246 MIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVAN 305
M+ARGDLGVE P+E +P++QK +I + G PVITAT+ML SM + PTRAE +DVAN
Sbjct: 236 MVARGDLGVECPMEDVPMIQKRIIAQCRDAGVPVITATEMLDSMVHARRPTRAEASDVAN 295
Query: 306 AILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIK 365
A+LDGTD VMLS ETA+G P V+ M +I + E E DGT T
Sbjct: 296 AVLDGTDGVMLSAETAVGDNPTRVVETMDRIVREVEGSAEYSERQEQAVPTADGTAKT-- 353
Query: 366 EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV 425
+A+ARS ++ ++ + +G TAR ++F+P + + + V L ++GV
Sbjct: 354 DALARSARYLARDIDASAVVVASESGYTARKAAKFRPSVPVVCATPSHDVRRQLALNWGV 413
Query: 426 YA--FCLEEGFDERDIIRLIKGL---GLVESDDIVLMTEG--KPIEKTMGTNSIKI 474
+A + EG + R ++ G+V S D V++ G +E TN++K+
Sbjct: 414 HANYAAVAEGDATTVVERAVQAAVDSGVVASGDTVVVLVGMMTELEGASTTNTLKV 469
>gb|AAC28104.1| (AF079586) pyruvate kinase; PK [Zymomonas mobilis]
Length = 475
Score = 271 bits (686), Expect = 1e-71
Identities = 158/471 (33%), Positives = 252/471 (52%), Gaps = 11/471 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
K ++V+T+GPA+S+ I+ G V R+N SHG+ +E +++ +R + ++ +R
Sbjct: 11 KVRVVSTLGPASSTAEQIRDRFLAGADVFRINMSHGTHDEKKVIVDNIRALEKEFNRPTT 70
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL DL G K+RVG+ K G V+LK G+ +GDET + + + + + + KG +
Sbjct: 71 ILFDLQGPKLRVGDFKEGKVQLKEGQTFTFDQDPTLGDETRVNLPHPEIFKALDKGHRLL 130
Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
L DG IV+R E + V G L KG N+P +P+ A+TP+D + + FA+++
Sbjct: 131 LDDGKIVVRCVESSPTKIVTRVEVPGPLSDHKGFNVPDVVIPLAALTPKDRKDLDFALKE 190
Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
D + LSFV V DV++ K ++ ++ K+E+P A+ N + IL A+D +M+AR
Sbjct: 191 KADWVALSFVQRVEDVIEAKELIKGRAP----LLVKLEKPAAIENLESILAATDAVMVAR 246
Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
GDLGVE E +P QK ++ ++ GKPV+ AT ML SM PTRAEV+DVANAI +
Sbjct: 247 GDLGVECLPESVPPTQKRIVERSRQLGKPVVVATAMLESMIKAPAPTRAEVSDVANAIYE 306
Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
G D +MLS E+A G +P +AV MM +IA E + G T +A+A
Sbjct: 307 GADGIMLSAESAAGDWPHEAVNMMHRIASYVE---NAPGYIERVRFTPTPAEPTTVDALA 363
Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
+ T+ K I+ T TG+TA+ +SR +P I + + V L +G
Sbjct: 364 ENASKTAETVGAKAIIVFTETGKTAQRVSRARPVAPILSLTPDAEVARRLGLVWGAQPVQ 423
Query: 430 LE--EGFDERDII--RLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQ 476
+ + DE + K G ++ D +++ G+P K TN + + +
Sbjct: 424 VSTVKTLDEAKKLAAETAKKYGFAKAGDKLVVVAGEPFGKAGTTNIVDVIE 474
>sp|P30615|KPY1_TRYBB PYRUVATE KINASE 1 (PK 1) >gi|102108|pir||S17648 pyruvate kinase (EC
2.7.1.40) isoform 1 - Trypanosoma brucei
>gi|10948|emb|CAA41018.1| (X57950) pyruvate kinase
[Trypanosoma brucei]
Length = 499
Score = 271 bits (685), Expect = 1e-71
Identities = 161/413 (38%), Positives = 244/413 (58%), Gaps = 8/413 (1%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
+IV TIGP+T S +K L+++G+SV R+NFSHGS E H I VR + +L + I
Sbjct: 23 RIVCTIGPSTQSVEALKNLMKSGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHIGIA 82
Query: 72 ADLPGLKIRVGEIKGGYVELKRGEKVVLTTR---DVVGDETTIPVEYKDFPRLVSKGDVI 128
D G +IR G K G V G+ V +TT + VG + ++Y V G I
Sbjct: 83 LDTKGPEIRTGLFKDGEVSFAPGDIVCVTTDPAYEKVGTKEKFYIDYPQLTNAVRPGGSI 142
Query: 129 YLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
Y+ DG + LRV + + ++ V + +L R+GIN+P + + AV+ +D + ++F +
Sbjct: 143 YVDDGVMTLRVVSKEDDRTLKCHVNNHHRLTDRRGINLPGCEVDLPAVSEKDRKDLEFGV 202
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
QGVD I SF+ + V +V++ L + +D+ +ISKIE V+N D I++AS+GIM+
Sbjct: 203 AQGVDMIFASFIRTAEQVREVRAALGEK-GKDILIISKIENHQGVQNIDSIIEASNGIMV 261
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E++ + Q +I K N GKPVI ATQML SMT+ PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPTRAEVSDVANAV 321
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKI-AKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
L+G D VMLS ETA GK+P + V+ MA+I + ++ + ++ L + +E
Sbjct: 322 LNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSIKNLQK--IPMCPEE 379
Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
A+ S + + + K +L + TGR+ARLIS+++P I +T + C L
Sbjct: 380 AVCSSAVASAFEVQAKAMLVLSNTGRSARLISKYRPNCPIICVTTRLQTCRQL 432
>sp|P30616|KPY2_TRYBB PYRUVATE KINASE 2 (PK 2) >gi|102107|pir||S17649 pyruvate kinase (EC
2.7.1.40) isoform 2 - Trypanosoma brucei
>gi|10950|emb|CAA41019.1| (X57951) pyruvate kinase
[Trypanosoma brucei]
Length = 499
Score = 271 bits (685), Expect = 1e-71
Identities = 161/413 (38%), Positives = 245/413 (58%), Gaps = 8/413 (1%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
+IV TIGP+T S +K L+++G+SV R+NFSHGS E H I VR + +L + I
Sbjct: 23 RIVCTIGPSTQSVEALKNLMKSGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHIGIA 82
Query: 72 ADLPGLKIRVGEIKGGYVELKRGEKVVLTTR---DVVGDETTIPVEYKDFPRLVSKGDVI 128
D G +IR G K G V G+ V +TT + VG + ++Y + V G I
Sbjct: 83 LDTKGPEIRTGLFKDGEVTFAPGDIVCVTTDPAYEKVGTKEKFYIDYPQLTKAVPVGGSI 142
Query: 129 YLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
Y+ DG + LRV + + ++ V + +L R+GIN+P + + AV+ +D + ++F +
Sbjct: 143 YVDDGVMTLRVLSKEDDRTLKCHVNNHHRLTDRRGINLPGCEVDLPAVSEKDRKDLEFGV 202
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
QGVD I SF+ + V +V++ L + +D+ +ISKIE V+N D I++AS+GIM+
Sbjct: 203 AQGVDMIFASFIRTAEQVREVRAALGEK-GKDILIISKIENHQGVQNIDSIIEASNGIMV 261
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLGVE+P E++ + Q +I K N GKPVI ATQML SMT+ PTRAEV+DVANA+
Sbjct: 262 ARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPTRAEVSDVANAV 321
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKI-AKVTEEYRESFGMSRLRELVEDGTRGTIKE 366
L+G D VMLS ETA GK+P + V+ MA+I + ++ + ++ L + +E
Sbjct: 322 LNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSIKNLQK--IPMCPEE 379
Query: 367 AIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
A+ S + + + K +L + TGR+ARLIS+++P I +T + C L
Sbjct: 380 AVCSSAVASAFEVQAKAMLVLSNTGRSARLISKYRPNCPIICVTTRLQTCRQL 432
>sp|P43924|KPYK_HAEIN PYRUVATE KINASE (PK) >gi|1075198|pir||C64130 pyruvate kinase (EC
2.7.1.40) - Haemophilus influenzae (strain Rd KW20)
>gi|1574410|gb|AAC23216.1| (U32831) pyruvate kinase,
type II (pykA) [Haemophilus influenzae Rd]
Length = 478
Score = 271 bits (685), Expect = 1e-71
Identities = 183/461 (39%), Positives = 264/461 (56%), Gaps = 15/461 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKIV T+GP+T N ++K+I G +VVR+NFSHG+ ++H E+VR I++KL + VA
Sbjct: 7 RTKIVCTMGPSTDRDNNLEKIIAAGANVVRMNFSHGTPDDHIGRAERVRSIAKKLGKTVA 66
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET--TIPVEYKDFPRLVSKGDV 127
IL DL G KIRV K G + L G+K +L G+ T ++ ++YK P+ V GD+
Sbjct: 67 ILGDLQGPKIRVSTFKDGKIFLNVGDKFILDAELPKGEGTQESVGLDYKTLPQDVVPGDI 126
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG + L+V G V V GG L + KGIN L +A+T +D I A
Sbjct: 127 LLLDDGRVQLKVLSTDGAKVFTEVTVGGPLSNNKGINKLGGGLSADALTEKDKADIITAA 186
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
GVD + +SF S D+ + L + + +++K+ER + V N D+I+ ASD
Sbjct: 187 RIGVDFLAVSFPRSSADLNYARE-LAQQAGLNAKIVAKVERAETVANDEAMDDIILASDV 245
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
IM+ARGDLGVE+ L +QK+LIR++ + VITATQM+ SM + +PTRAEV DVA
Sbjct: 246 IMVARGDLGVEIGDPELVGVQKKLIRRSRQLNRAVITATQMMESMISNPMPTRAEVMDVA 305
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
NA+LDGTDAVMLS ETA G++P + V MA + + E S +SR R D TI
Sbjct: 306 NAVLDGTDAVMLSAETAAGQYPSETVAAMASVC-LGAEKMPSINVSRHR---MDKEFETI 361
Query: 365 KEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
+E++A S + A + + I+T + TGRT L+SR IF S N+ N
Sbjct: 362 EESVAMSAMYAANHMKGVAAIVTLSSTGRTPLLMSRISSGLPIFALSRNQETLNLCALYR 421
Query: 424 GVY-AFCLEEGFDE---RDIIRLIKGLGLVESDDIVLMTEG 460
GV + EE E + + +K G + + D+VL+T+G
Sbjct: 422 GVTPIYHGEESRTEAGAKAAPQSLKEKGYLSTGDLVLVTQG 462
>gb|AAF55979.1| (AE003738) PyK gene product [Drosophila melanogaster]
Length = 533
Score = 271 bits (685), Expect = 1e-71
Identities = 158/403 (39%), Positives = 241/403 (59%), Gaps = 15/403 (3%)
Query: 13 IVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVR----DISQKL--DR 66
IV TIGPA+SS M++K++ G+++ R+NFSHGS E HA + VR + S KL +
Sbjct: 50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEH 109
Query: 67 RVAILADLPGLKIRVGEIKGG---YVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVS 123
VAI D G +IR G I G +ELK+GEK+ LTT ++ ++ + Y D+ +V+
Sbjct: 110 PVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVN 169
Query: 124 ---KGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
G+ +++ DG I L V EV + V +GG L SRKG+N+P + + AV+ +D
Sbjct: 170 VVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDK 229
Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
+ F +EQ VD I SF+ + + +++ L + +++ +ISKIE + N DEI++
Sbjct: 230 SDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEK-GKNIKIISKIENQQGMHNLDEIIE 288
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
A DGIM+ARGDLG+E+P E++ + QK +I + N GKPVI ATQML SM + PTRAE+
Sbjct: 289 AGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEI 348
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
+DVANA+LDG D VMLS ETA G++P++ V MAK K E + + +LV
Sbjct: 349 SDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAE--AALWHQNLFNDLVRGAG 406
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPK 403
A A + ++A I+ T +G++A +S+++P+
Sbjct: 407 TIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPR 449
>sp|P57404|KPYK_BUCAI PYRUVATE KINASE (PK) >gi|10038993|dbj|BAB13027.1| (AP001119)
pyruvate kinase [Buchnera sp. APS]
Length = 480
Score = 271 bits (685), Expect = 1e-71
Identities = 185/478 (38%), Positives = 268/478 (55%), Gaps = 15/478 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKIVAT+GP+T N ++K+I +GV+V+R NFSHGS +EH + R+I +L+ +A
Sbjct: 7 RTKIVATLGPSTDINNNLEKIIRSGVNVLRFNFSHGSKDEHKSRANQAREIMTRLNFHIA 66
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDV 127
+L DL G KIR+ + + L G+ +L G++ + ++YK P + GDV
Sbjct: 67 LLGDLQGPKIRISKFIKNNIFLNVGDFFILDANLDQNNGNQERVGIDYKQLPYDLKVGDV 126
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG I L+V + G ++ VV GG L + KGIN L +A+T +D + I A
Sbjct: 127 LLLDDGRIQLKVIKSTGHEILTKVVIGGILSNNKGINKLGGGLSADALTEKDKKDIILAT 186
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
E VD + +SF D+ + + L K + +I+KIER +AV N ++I+ ASD
Sbjct: 187 EINVDYLAISFPRCSNDLKQARK-LAKEFGSNAKIIAKIERAEAVLNQNTIEDIILASDA 245
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
IMIARGDLGVE+ L +QK+LIR A + VITATQM+ SM +PTRAEV DVA
Sbjct: 246 IMIARGDLGVEIGDSELAGIQKKLIRTARQLNRIVITATQMMESMITNPLPTRAEVMDVA 305
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
NA+LDG+DAVMLS ETA G++P + V MAKI K E+ S +SR R I
Sbjct: 306 NAVLDGSDAVMLSAETASGEYPAETVIKMAKICKGAEKV-PSINVSRHR---IHAKFDDI 361
Query: 365 KEAIARSIIDALCTL-NIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSY 423
+EAIA S + L I I+T T +G+TA + SR IF S N+ N
Sbjct: 362 EEAIAMSAMYVANHLKGITAIITMTESGKTALMTSRITSGLPIFALSKNKETLNLASLYR 421
Query: 424 GV---YAFCLEEGFD-ERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQI 477
GV Y F + I L++ G + ++V++T+G + K TN+ +I ++
Sbjct: 422 GVTPIYFNSKNNNFKAANEAIVLLRKRGFLCRGELVIITQGDIMGKIGKTNTSRILKV 479
>sp|O05118|KPYK_METEX PYRUVATE KINASE (PK) >gi|1907336|gb|AAB66498.1| (U87316) pyruvate
kinase [Methylobacterium extorquens]
Length = 483
Score = 270 bits (684), Expect = 2e-71
Identities = 169/470 (35%), Positives = 257/470 (53%), Gaps = 13/470 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKIVAT+GPA+ + MI+KL G V R+N SH + E+ + IE +R I ++ R +
Sbjct: 11 RTKIVATLGPASDTPEMIEKLFHAGADVFRINMSHLAREKLPERIEVIRTIEREGKRPIG 70
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
IL DL G K+R+G G L+ G+ VL + GD + + + + + I
Sbjct: 71 ILVDLQGPKLRLGTFVGDAAVLENGQTFVLDSDPTPGDTDRVFLPHPEILSALEPSHGIL 130
Query: 130 LSDGYIVLRVEEV-RGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
+ DG + L V EV G+ V V V GG++ +RKG+++P LPV A+T +D ++ +
Sbjct: 131 IDDGKLRLIVTEVSEGRAVTRVEV-GGRISNRKGVSLPHTALPVPAMTEKDRGDLEAGLA 189
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
G D I +SFV DV +VK K A V++KIE+P A+ DEI++ SDGIM+A
Sbjct: 190 AGADWIAVSFVQRPEDVAEVK----KVAAGRALVMAKIEKPQALTRLDEIIEISDGIMVA 245
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLGVEMP+E++P +QK + R A GKPV+ ATQML SM VPTRAEV+DVA A+
Sbjct: 246 RGDLGVEMPLEQVPGVQKRITRVARRLGKPVVVATQMLESMITSPVPTRAEVSDVATAVY 305
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
+G DAVMLS E+A G FP++A+ M +IA+ E + + + + T A
Sbjct: 306 EGADAVMLSAESAAGDFPVEAIGTMNRIAEQVERDALYWSILMAQRSEPEPTASDAIAAA 365
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
A I++A L+++ I+ T +G T ++R +P + + L ++GV+
Sbjct: 366 AHQIVEA---LSLRSIMAWTHSGSTVLRLARARPNASVIALTPKRETARRLTMAWGVHPI 422
Query: 429 CLEEGFDERDI----IRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
++ D D+ + E D V++ G P TN ++I
Sbjct: 423 VTKDASDVDDMAFRAAKFAVRERFAEIGDRVIIVAGVPFGIPGATNMVRI 472
>dbj|BAB10440.1| (AB009055) pyruvate kinase [Arabidopsis thaliana]
Length = 579
Score = 270 bits (683), Expect = 2e-71
Identities = 168/475 (35%), Positives = 261/475 (54%), Gaps = 13/475 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDIS-QKLDRRV 68
KTKIV T+GP+T++R MI KL E G++V R+N SHG H KVI+ V++ + Q D +
Sbjct: 111 KTKIVCTVGPSTNTREMIWKLAEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDNTI 170
Query: 69 AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVI 128
AI+ D G ++R G++ + L G++ T V + + V Y DF V GD++
Sbjct: 171 AIMLDTKGPEVRSGDLPQP-IMLDPGQEFTFTIERGVSTPSCVSVNYDDFVNDVEAGDML 229
Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
+ G + V+ V+ VV GG+L SR+ +N+ + ++T +D E IKF +E
Sbjct: 230 LVDGGMMSFMVKSKTKDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVE 289
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
VD +SFV V ++K +L+ N D+ VI KIE D++ N I+ ASDG M+A
Sbjct: 290 NKVDFYAVSFVKDAQVVHELKKYLQ-NSGADIHVIVKIESADSIPNLHSIITASDGAMVA 348
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLG E+PIE +PILQ+E+I + GK VI AT ML SM PTRAEV+D+A A+
Sbjct: 349 RGDLGAELPIEEVPILQEEIINLCRSMGKAVIVATNMLESMIVHPTPTRAEVSDIAIAVR 408
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
+G DAVMLS ETA GKFP+ A +M +A TE + + + + + E
Sbjct: 409 EGADAVMLSGETAHGKFPLKAAGVMHTVALRTE---ATITSGEMPPNLGQAFKNHMSEMF 465
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
A TL ++ TRTG A L+S ++P I+ F+ +++ L GV
Sbjct: 466 AYHATMMSNTLGTSTVVF-TRTGFMAILLSHYRPSGTIYAFTNEKKIQQRLALYQGVCPI 524
Query: 429 CLEEGFDERD-----IIRLIKGLGLVESDDIVLMTEG-KPIEKTMGTNSIKIFQI 477
+E D + + L+K + + ++I ++ G +PI ++ T++I++ ++
Sbjct: 525 YMEFTDDAEETFANALATLLKQGMVKKGEEIAIVQSGTQPIWRSQSTHNIQVRKV 579
>dbj|BAB11262.1| (AB009049) pyruvate kinase [Arabidopsis thaliana]
Length = 498
Score = 269 bits (681), Expect = 4e-71
Identities = 164/401 (40%), Positives = 242/401 (59%), Gaps = 13/401 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S M++KL+ G++V R NFSHGS E H + ++ + A
Sbjct: 9 KTKIVCTLGPASRSVPMVEKLLRAGMNVARFNFSHGSHEYHQETLDNLHQAMLNTGILCA 68
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G ++LK+G+++ ++T D+ GDE TI + YK V+ G V
Sbjct: 69 VMLDTKGPEIRTGFLKDGKPIQLKQGQEITISTDYDLKGDENTICMSYKKLAVDVNPGMV 128
Query: 128 IYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-IIK 184
I +DG I L V ++ V + L RK +N+P + + +T +D E I++
Sbjct: 129 ILCADGTISLLVLSCDKENGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDIMQ 188
Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
+ + +D I LSFV D+++V+ L K+ A+++ ++SK+E + V NFD+IL SD
Sbjct: 189 WGVPNQIDMIALSFVRKGSDLVQVRKLLGKH-AKNILLMSKVENQEGVANFDDILVNSDA 247
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
MIARGDLG+E+PIE++ + QK +I K N +GKPV+TATQML SM PTRAE TDVA
Sbjct: 248 FMIARGDLGMEIPIEKIFLAQKVMIYKCNIQGKPVVTATQMLESMIKSPRPTRAEATDVA 307
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVEDGTR 361
NA+LDGTD VMLS ETA G +P AV+ MAKI A+ T +Y + F L V
Sbjct: 308 NAVLDGTDCVMLSGETAAGAYPELAVRTMAKICVEAESTLDYGDVFKRIMLYSPVPMSPL 367
Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
++ + R+ A TL I+ TR G TARL+++++P
Sbjct: 368 ESLASSAVRTANSARATL----IMVLTRGGSTARLVAKYRP 404
>sp|P32044|KPYK_THEAC PYRUVATE KINASE (PK) >gi|10640173|emb|CAC12025.1| (AL445065)
pyruvate kinase related protein [Thermoplasma
acidophilum]
Length = 544
Score = 269 bits (681), Expect = 4e-71
Identities = 165/468 (35%), Positives = 261/468 (55%), Gaps = 25/468 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIVATIGPA+SS ++K++I+NG+S+VR+N +H ++ +K+ + VR I+ R V
Sbjct: 2 KTKIVATIGPASSSPEIMKQMIDNGLSLVRINSAHADIKDVSKITQMVRSIN----RDVG 57
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIY 129
I+ DL G ++R GE GG +++ G+ V+ V+ + + V GD I
Sbjct: 58 IMIDLKGPELRTGEFAGGTLKISSGKDYVMGKDIVLNNMNVLSA--------VQVGDRIL 109
Query: 130 LSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQ 189
+SDG + VE + A+ + G L R +NIP ++ + +T RD I+ I
Sbjct: 110 MSDGEVSFEVESTDPFTIRAL--NDGVLRDRSRVNIPGRFIELGTITDRDRAFIREGIAD 167
Query: 190 GVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIAR 249
GVD LSFV +V ++ F+ + D ++ISKIE + N +EI+K+SDGIM+AR
Sbjct: 168 GVDFFALSFVQKSENVDSLRDFVIDSGG-DQYIISKIETKSGLDNIEEIVKSSDGIMVAR 226
Query: 250 GDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILD 309
GDLGVE+P++ + + QK +I+ A+ +G I ATQ+L SM PTRAE++D+ NAI+D
Sbjct: 227 GDLGVELPLKEVVLAQKHIIKTAHEDGDFTIVATQVLESMVNNSSPTRAEISDITNAIID 286
Query: 310 GTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAIA 369
DA+MLSEE+AIGK+P+ AV+ + +++ E+ + SF S + TI ++A
Sbjct: 287 NADALMLSEESAIGKYPVQAVRTLKEVSDYVED-KVSFDSSYYFK------GNTIAYSVA 339
Query: 370 RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFC 429
R+ + I+ T TG T R+IS +PK ++ + +E + L +GV
Sbjct: 340 RAAKILSDDIKSDGIVALTHTGSTVRMISSLRPKAMVYAATVSESLARKLNIYFGVLPLH 399
Query: 430 LE---EGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKI 474
+E E +I+ I G ++MT G P GTN +K+
Sbjct: 400 MEGNAEDLSFSEIMEYIVRSGRFADGSKLVMTSGDPYFTFGGTNDVKV 447
>gi|6319279 Pyruvate kinase; Cdc19p [Saccharomyces cerevisiae]
>gi|125609|sp|P00549|KPY1_YEAST PYRUVATE KINASE 1
>gi|66859|pir||KIBYP pyruvate kinase (EC 2.7.1.40) -
yeast (Saccharomyces cerevisiae) >gi|3212328|pdb|1A3W|A
Chain A, Pyruvate Kinase From Saccharomyces Cerevisiae
Complexed With Fbp, Pg, Mn2+ And K+
>gi|3212329|pdb|1A3W|B Chain B, Pyruvate Kinase From
Saccharomyces Cerevisiae Complexed With Fbp, Pg, Mn2+
And K+ >gi|3212330|pdb|1A3X|A Chain A, Pyruvate Kinase
From Saccharomyces Cerevisiae Complexed With Pg, Mn2+
And K+ >gi|3212331|pdb|1A3X|B Chain B, Pyruvate Kinase
From Saccharomyces Cerevisiae Complexed With Pg, Mn2+
And K+ >gi|5265|emb|CAA32573.1| (X14400) pyruvate kinase
(AA 1 - 500) [Saccharomyces cerevisiae]
>gi|595546|gb|AAC04993.1| (U12980) Cdc19p: pyruvate
kinase [Saccharomyces cerevisiae]
Length = 500
Score = 268 bits (679), Expect = 7e-71
Identities = 164/433 (37%), Positives = 251/433 (57%), Gaps = 16/433 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL--DRR 67
+T I+ TIGP T++ + L + G+++VR+NFSHGS+E H VI+ R S++L R
Sbjct: 20 RTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARK-SEELYPGRP 78
Query: 68 VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVG---DETTIPVEYKDFPRLVS 123
+AI D G +IR G + +++ TT D D+ + V+YK+ +++S
Sbjct: 79 LAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVIS 138
Query: 124 KGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI 182
G +IY+ DG + +V E V + ++ ++ GK+ S KG+N+P + + A++ +D E
Sbjct: 139 AGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKED 198
Query: 183 IKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
++F ++ GV + SF+ + DVL ++ L + +DV +I KIE V NFDEILK +
Sbjct: 199 LRFGVKNGVHMVFASFIRTANDVLTIREVLGEQ-GKDVKIIVKIENQQGVNNFDEILKVT 257
Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
DG+M+ARGDLG+E+P + +QK+LI K+N GKPVI ATQML SMT PTRAEV+D
Sbjct: 258 DGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSD 317
Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDG 359
V NAILDG D VMLS ETA G +PI+AV MA+ A + E+ Y ++ +R
Sbjct: 318 VGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNY--DDMRNCTPKP 375
Query: 360 TRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
T T E +A S + A+ K I+ + +G T RL+S+++P I + R
Sbjct: 376 TSTT--ETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFS 433
Query: 420 MFSYGVYAFCLEE 432
GV+ F E+
Sbjct: 434 HLYRGVFPFVFEK 446
>sp|Q10208|KPYK_SCHPO PYRUVATE KINASE >gi|7493249|pir||T38890 pyruvate kinase (EC
2.7.1.40) - fission yeast (Schizosaccharomyces pombe)
>gi|1184023|emb|CAA93349.1| (Z69380) pyruvate kinase (EC
2.7.1.40) [Schizosaccharomyces pombe]
Length = 509
Score = 268 bits (677), Expect = 1e-70
Identities = 156/408 (38%), Positives = 243/408 (59%), Gaps = 21/408 (5%)
Query: 8 DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDR- 66
+ +T I+ TIGP +++ + KL + G+++VR+NFSHGS+E H VI+ R S
Sbjct: 25 NRRTSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASATNPLF 84
Query: 67 RVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVGD---ETTIPVEYKDFPRLV 122
+AI D G +IR G GG + G +++ TT D + + + ++YK+ +++
Sbjct: 85 PLAIALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVI 144
Query: 123 SKGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
G +IY+ DG + V E+V ++++ V + GK+ S+KG+N+PK + + A++ +D
Sbjct: 145 QPGRIIYVDDGILSFTVIEKVDDKNLKVRVNNNGKISSKKGVNLPKTDVDLPALSEKDKA 204
Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
++F ++ GVD I SF+ DV+ ++ L + + +++ +I KIE V NFD IL
Sbjct: 205 DLRFGVKNGVDMIFASFIRRAEDVIHIREVLGE-EGKNIKIICKIENQQGVNNFDSILDV 263
Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
+DGIM+ARGDLG+E+P ++ + QK +I K N GKPV ATQML SMT PTRAEV+
Sbjct: 264 TDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVS 323
Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE-------YRESFGMSRLRE 354
DV NA+LDG D VMLS ET G +P++AV MA+ A+V E Y+E FG+ +R
Sbjct: 324 DVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMFGL--VRR 381
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+E T T AI SI + K I+ + +G TARL S+++P
Sbjct: 382 PLECATETTAVAAIGASI-----ESDAKAIVVLSTSGNTARLCSKYRP 424
>pir||T45166 pyruvate kinase (EC 2.7.1.40) [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|1200144|emb|CAA62490.1|
(X91008) pyruvate kinase [Schizosaccharomyces pombe]
>gi|1586497|prf||2204219A pyruvate kinase
[Schizosaccharomyces pombe]
Length = 509
Score = 267 bits (675), Expect = 2e-70
Identities = 156/408 (38%), Positives = 243/408 (59%), Gaps = 21/408 (5%)
Query: 8 DHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDR- 66
+ +T I+ TIGP +++ + KL + G+++VR+NFSHGS+E H VI+ R S
Sbjct: 25 NRRTSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASATNPLF 84
Query: 67 RVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVGD---ETTIPVEYKDFPRLV 122
+AI D G +IR G GG + G +++ TT D + + + ++YK+ +++
Sbjct: 85 PLAIALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVI 144
Query: 123 SKGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
G +IY+ DG + V E+V ++++ V + GK+ S+KG+N+PK + + A++ +D
Sbjct: 145 QPGRIIYVDDGILSFTVIEKVDDKNLKVRVNNNGKISSKKGVNLPKTDVDLPALSEKDKA 204
Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
++F ++ GVD I SF+ DV+ ++ L + + +++ +I KIE V NFD IL
Sbjct: 205 DLRFGVKNGVDMIFASFIRRAEDVIHIREVLGE-EGKNIKIICKIENQQGVNNFDSILDV 263
Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
+DGIM+ARGDLG+E+P ++ + QK +I K N GKPV ATQML SMT PTRAEV+
Sbjct: 264 TDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVS 323
Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE-------YRESFGMSRLRE 354
DV NA+LDG D VMLS ET G +P++AV MA+ A+V E Y+E FG+ +R
Sbjct: 324 DVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMFGL--VRR 381
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+E T T AI SI + K I+ + +G TARL S+++P
Sbjct: 382 PLECATETTRVAAIGASI-----ESDAKAIVVLSTSGNTARLCSKYRP 424
>gb|AAF05863.1|AC011698_14 (AC011698) putative pyruvate kinase [Arabidopsis thaliana]
Length = 510
Score = 266 bits (674), Expect = 3e-70
Identities = 159/399 (39%), Positives = 242/399 (59%), Gaps = 9/399 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S M++KL++ G++V R NFSHGS H + ++ +R + A
Sbjct: 17 KTKIVCTLGPASRSVEMVEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMENTCIPCA 76
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G VEL +G+++ ++T + GD TI + YK + GDV
Sbjct: 77 VMLDTKGPEIRTGFLKEGKPVELIQGQEITISTDYTMEGDSNTISMSYKKLAEDLKSGDV 136
Query: 128 IYLSDGYI---VLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
I SDG I VL ++ G V A + L RK +N+P + + +T +D E I+
Sbjct: 137 ILCSDGTISLTVLSCDKNLGL-VRARCENSAVLGERKNVNLPGIVVDLPTLTEKDQEDIL 195
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
++ + +D I LSFV D+++V+ L +N A+ + ++SK+E + V NFD+IL+ SD
Sbjct: 196 QWGVPNKIDIIALSFVRKGSDLVEVRKLLGEN-AKSIMLMSKVENQEGVMNFDKILEYSD 254
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
M+ARGDLG+E+PIE++ + QK +I+KAN GKP++TATQML SMT PTRAE TDV
Sbjct: 255 AFMVARGDLGMEIPIEKMFLAQKMMIQKANALGKPIVTATQMLESMTKSPRPTRAEATDV 314
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
ANA+LDGTD VMLS ETA G P AV M++I K E++ + M + + +
Sbjct: 315 ANAVLDGTDCVMLSGETAAGAHPETAVLTMSRICKEAEDFIDYDTMHKKIQDIVSLPLSP 374
Query: 364 IKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
I E++A S + +L I+ T+ G T L+++++P
Sbjct: 375 I-ESLAASAVSTARSLCAAAIVVLTKGGYTVELVAKYRP 412
>pir||F81684 pyruvate kinase TC0609 [imported] - Chlamydia muridarum (strain
Nigg) >gi|7190647|gb|AAF39440.1| (AE002329) pyruvate
kinase [Chlamydia muridarum]
Length = 481
Score = 266 bits (673), Expect = 4e-70
Identities = 159/425 (37%), Positives = 247/425 (57%), Gaps = 4/425 (0%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKI+ TIGPAT++ M++KL++ G++V RLNFSHG+ E H + I ++++ +K +A
Sbjct: 4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLA 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKD--FPRLVSKGDV 127
I+ D G +IR+G+++ +++K G+++ LT+++++G + Y FP + + V
Sbjct: 64 IMLDTKGPEIRLGQVESP-IKVKPGDRLTLTSKEILGSKEAGVTLYPSCVFPFVRERAPV 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DGYI V + +E + G++ S K ++I + + +T +D+ +KF +
Sbjct: 123 L-IDDGYIQAVVVNAQEHLIEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDITDLKFGV 181
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQ +D I SFV D+ ++ LE ++ +I+KIE V+NF EI KASDGIMI
Sbjct: 182 EQELDLIAASFVRCNEDIDSMRKVLENFGRPNMPIIAKIENHLGVQNFQEIAKASDGIMI 241
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLG+E+ I +P LQK + R + G+ ITATQML SM +PTRAEV+DVANAI
Sbjct: 242 ARGDLGIELSIVEVPALQKFMARVSRETGRFCITATQMLESMIRNPLPTRAEVSDVANAI 301
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
DGT AVMLS ETA G +PI+AVK M I + TE+ + +L + EA
Sbjct: 302 HDGTSAVMLSGETASGTYPIEAVKTMRSIIQETEKSFDYQAFFQLNDKNSALKVSPYLEA 361
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYA 427
I S I + K I+ T+TG + +S+++P I + N V L +GVY
Sbjct: 362 IGASGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVYP 421
Query: 428 FCLEE 432
E
Sbjct: 422 MLTSE 426
>pir||JC2456 pyruvate kinase (EC 2.7.1.40) - Trypanoplasma borelli
>gi|673500|emb|CAA54473.1| (X77255) pyruvate kinase
[Trypanoplasma borreli]
Length = 497
Score = 265 bits (671), Expect = 6e-70
Identities = 158/417 (37%), Positives = 246/417 (58%), Gaps = 10/417 (2%)
Query: 12 KIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAIL 71
KI+ TIGP++ S ++K L++ G++V R+NFSHG++E H K I+ VR + +L V I
Sbjct: 25 KIICTIGPSSQSVEVLKDLMKAGLNVARMNFSHGTYEYHQKTIDNVRKAASELGIHVGIA 84
Query: 72 ADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIP---VEYKDFPRLVSKGDVI 128
D G +IR G G V ++ + V+LTT + ++ T V+Y + ++V G I
Sbjct: 85 LDTKGPEIRTGLFPAGDVVIEAHKTVILTTDETFKEKGTAEKFYVDYMNITKVVPVGGHI 144
Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
++ DG + L V ++ G+D+E V + + +RKGIN+P A + + AV+ +D+ ++F +
Sbjct: 145 FVDDGLLDLIVVKISGKDIECVAQNTHTISNRKGINLPNADVDLPAVSEKDLMDLQFGAK 204
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
VD + SF+ + V +V+ + VI+KIE + N D I+ A+DGIM+A
Sbjct: 205 NRVDFVFASFIRNADQVNEVRQAF----GGKIAVIAKIENYQGIDNIDAIIDAADGIMVA 260
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLGVE+P E++ I QK ++ K N GK VI ATQML SMT PTRAEV+DVA ++L
Sbjct: 261 RGDLGVEIPAEKVVIAQKMIMSKCNKVGKTVICATQMLDSMTHGPRPTRAEVSDVAKSVL 320
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI-KEA 367
DG D VMLS ETA GK+P++ V M++I T+ + M+ + + I +EA
Sbjct: 321 DGADCVMLSGETAKGKYPVETVVYMSRICCETQV--TMWNMAAFEAIKNLQSFPLIPEEA 378
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYG 424
I S ++++ L+ K IL T TGR+A ++S+++P I S VC L + G
Sbjct: 379 ICSSAVNSIFELHAKAILVLTNTGRSAHMVSKYRPPVPIICASQELDVCRLLSITRG 435
>gb|AAF55980.2| (AE003738) CG7069 gene product [Drosophila melanogaster]
Length = 744
Score = 265 bits (669), Expect = 1e-69
Identities = 168/438 (38%), Positives = 248/438 (56%), Gaps = 24/438 (5%)
Query: 37 VVRLNFSHGSFEEHAKVIEKVRDI------SQKLDRRVAILADLPGLKIRVGEIKGGY-- 88
VVR+NFSHGS E H + I+ R L R +AI D G +IR G++ GG
Sbjct: 3 VVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDR 62
Query: 89 --VELKRGEKVVLTTRDVVGDETT---IPVEYKDFPRLVSKGDVIYLSDGYIVLRVEEVR 143
+ELK G+KV L+T+ + D++ I V+Y+ P+LV G+ +++ DG I L V+E +
Sbjct: 63 AEIELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESK 122
Query: 144 GQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVY 203
G +V V +GGKL S KGIN+P + + +VT +D + +KF EQ VD I SF+
Sbjct: 123 GDEVICQVENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDAN 182
Query: 204 DVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPI 263
+ +++ L A + +ISKIE + N D+I++ SDGIM+ARGD+G+E+P E +P+
Sbjct: 183 ALKEIRQVLGPAGA-CIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPL 241
Query: 264 LQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIG 323
QK ++ K N GKPVI ATQM+ SMT + PTRAE +DVANAI DG DAVMLS ETA G
Sbjct: 242 AQKSIVAKCNKVGKPVICATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKG 301
Query: 324 KFPIDAVKMMAKIAKVTEE--YRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNI 381
K+P++ V+ MA+I E + ES S RE+ A+ +I +A
Sbjct: 302 KYPVECVQCMARICAKVEAVLWYESLQNSLKREIRTSAADHI--SAVTTAIAEAATVGQA 359
Query: 382 KYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEE----GFDER 437
+ I+ + A+++S +P I + NE + G+Y +EE F+ R
Sbjct: 360 RAIVVASPCSMVAQMVSHMRPPCPIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSFNFR 419
Query: 438 DIIRLIKGLGLVESDDIV 455
I++ GL L+ DI+
Sbjct: 420 RIMQ--SGLKLMGKMDIL 435
>gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus]
Length = 500
Score = 263 bits (666), Expect = 2e-69
Identities = 172/501 (34%), Positives = 274/501 (54%), Gaps = 44/501 (8%)
Query: 10 KTKIVATIGPAT---------------------SSRNMIKKLIENGVSVVRLNFSHGSFE 48
+ KIVAT+GPA +S I +LIE G +V R NFSHG+
Sbjct: 4 RVKIVATLGPAVEIRGGKKFGEDGYWSEKLDPDASAKNIAQLIEEGANVFRFNFSHGNHA 63
Query: 49 EHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVEL--KRGEKVVL------- 99
E + ++ VR ++V L D G +IR +G E K GE++ +
Sbjct: 64 EQGERMDVVRMAESIAGQKVGFLLDTKGPEIRTELFEGDAKEYAYKTGEQIRIATKQGLK 123
Query: 100 TTRDVVGDETTIPVEYKDFPRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVV--SGGKL 157
+TRDV+ ++ D V G + + DG + LRV + + E +V + G +
Sbjct: 124 STRDVIALNVAGALDIFDD---VEVGKQVLVDDGKLGLRVVDKDAEKREFIVEVENDGII 180
Query: 158 FSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDA 217
+KG+NIP +P A+ RD I+F +EQG++ I +SFV + DV +V++ E+
Sbjct: 181 AKQKGVNIPYTKIPFPALAERDNADIRFGLEQGINFIAISFVRTAKDVQEVRAICEETGN 240
Query: 218 EDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGK 277
V +++KIE + N DEI++A+DGIMIARGD+G+E+P E +P+ QK +I K N GK
Sbjct: 241 GHVKLLAKIENQQGIDNIDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGK 300
Query: 278 PVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIA 337
V+TAT ML +MT + TR+EV+DV NA++DGTDA MLS E+A G +P+++V+ MA I
Sbjct: 301 IVVTATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGPYPVESVRTMATIH 360
Query: 338 KVTEEYRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLI 397
K + + +G RL D + T E +A ++ DA +++I+ I+ T +G TA LI
Sbjct: 361 KNAQTLLKEYG--RLNSSTFDRSSNT--EVVASAVKDATNSMHIQLIVALTESGNTASLI 416
Query: 398 SRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIKGL----GLVESDD 453
++P+ I+ + +E +LM ++GV E D+ + + + GLVES D
Sbjct: 417 DTYRPEADIWAITFDELTQKSLMLNWGVIPVVTETPSSTDDMFEVAERVALESGLVESGD 476
Query: 454 IVLMTEGKPIEKTMGTNSIKI 474
+++ G P+ + TN+++I
Sbjct: 477 NIVIVAGVPV-GSGNTNTMRI 496
>pir||JC1267 pyruvate kinase (EC 2.7.1.40) - yeast (Yarrowia lipolytica)
Length = 527
Score = 262 bits (663), Expect = 5e-69
Identities = 167/449 (37%), Positives = 251/449 (55%), Gaps = 27/449 (6%)
Query: 34 GVSVVRLNFSHGSFEEHAKVIEKVRDISQKL-DRRVAILADLPGLKIRVGEIKGGYV-EL 91
G+++VR+NFSHGS+E H VIE R+ Q+ R +AI D G +IR G K ++
Sbjct: 40 GLNIVRMNFSHGSYEYHQSVIENARESEQRFRGRPLAIALDTKGPEIRTGVTKDDKDWDV 99
Query: 92 KRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSK---GDVIYLSDGYIVLRV-EEVRGQDV 147
K G ++ +T D+ + Y D+ +V + G +I++ DG + +V E++ G+ +
Sbjct: 100 KAGHVMLFSTNPKYKDQCDDKIMYIDYTNIVKQIDIGKIIFVDDGVLSFKVLEKIDGETL 159
Query: 148 EAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLK 207
+ ++ GK+ SRKG+N+P + + A++ +D +KF +E GVD I SFV + DV
Sbjct: 160 KVETLNNGKISSRKGVNLPGTDVDLPALSEKDKADLKFGVEHGVDMIFASFVRTANDVQA 219
Query: 208 VKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKE 267
++ L + + + VISKIE V NFDEILK +DG+M+ARGDLG+E+P ++ I QK+
Sbjct: 220 IRDVLGEK-GKGIQVISKIENQQGVNNFDEILKETDGVMVARGDLGIEIPAPQVFIAQKQ 278
Query: 268 LIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPI 327
LI K N GKPVI ATQML SMT PTRAEV+DV NA+LDG D VMLS ETA G +PI
Sbjct: 279 LIAKCNLAGKPVICATQMLDSMTYNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGTYPI 338
Query: 328 DAVKMMAKIAKVTEE---YRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYI 384
++VKMM + V E+ Y F + +R L T E IA S + A + I
Sbjct: 339 ESVKMMHETCLVAEKAIAYAPLF--NEMRTLTVRPTETV--ETIAISAVSASFEQQARAI 394
Query: 385 LTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFD------ERD 438
+ + +G +ARL S+++P I + N + GVY F + + D
Sbjct: 395 IVLSTSGTSARLCSKYRPNCPILMVTRNAQAARFSHLYRGVYPFIYHKARASNPAEWQHD 454
Query: 439 IIRLIK-------GLGLVESDDIVLMTEG 460
+ +K LG++ D+V+ +G
Sbjct: 455 VEERLKWGMDEAVALGILNKGDVVVAIQG 483
>dbj|BAB01059.1| (AB023041) pyruvate kinase [Arabidopsis thaliana]
Length = 497
Score = 262 bits (663), Expect = 5e-69
Identities = 156/405 (38%), Positives = 239/405 (58%), Gaps = 21/405 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S MI+KL++ G++V R NFSHGS H + ++ +R A
Sbjct: 17 KTKIVCTLGPASRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGILCA 76
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D IR G +K G ++LK+G+++ ++ + GD TI + YK + GDV
Sbjct: 77 VMLDTKSPVIRTGFLKEGKPIQLKQGQEITISIDYKIQGDSNTISMSYKKLAEDLKPGDV 136
Query: 128 IYLSDGYIVLRV---EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
I SDG I L V ++ G V + L RK +N+P + + +T +D E I+
Sbjct: 137 ILCSDGTISLNVLSCDKYLGL-VRCRCENSALLGERKNVNLPGIVVDLPTLTEKDKEDIM 195
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
++ + +D I LSFV D+++V+ L ++ ++ + ++SK+E + V NFD+IL+ SD
Sbjct: 196 QWGVPNKIDIIALSFVRKGSDLIQVRKLLGEH-SKSIMLMSKVENQEGVMNFDKILENSD 254
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
M+ARGDLG+E+PIE++ + QK +I KAN GKPV+TATQML SMT PTRAE TDV
Sbjct: 255 AFMVARGDLGMEIPIEKMFLAQKTMINKANAHGKPVVTATQMLESMTVSPRPTRAEATDV 314
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
ANA+LDGTD VMLS ETA G P AV M++I K E++ + +++ T G
Sbjct: 315 ANAVLDGTDCVMLSGETAAGAHPETAVLTMSRICKEAEDFID-------YDILHKKTLGM 367
Query: 364 IK------EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S + ++ I+ TR G TA L+++++P
Sbjct: 368 VSLPLSPIESLAASAVSTARSVFASAIVVLTRGGYTAELVAKYRP 412
>emb|CAA24631.1| (V01321) pyruvate kinase [Saccharomyces cerevisiae]
Length = 499
Score = 262 bits (662), Expect = 7e-69
Identities = 162/433 (37%), Positives = 251/433 (57%), Gaps = 17/433 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL--DRR 67
+T I+ TIGP T++ + L + G+++VR+NFSHGS+E H VI+ R S++L R
Sbjct: 20 RTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARK-SEELYPGRP 78
Query: 68 VAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVG---DETTIPVEYKDFPRLVS 123
+AI D G +IR G + +++ TT D D+ + V+YK+ +++S
Sbjct: 79 LAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVIS 138
Query: 124 KGDVIYLSDGYIVLRV-EEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI 182
G +IY+ DG + +V E V + ++ ++ GK+ S KG+N+P + + A++ +D E
Sbjct: 139 AGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKED 198
Query: 183 IKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKAS 242
++F ++ GV + SF+ + DVL ++ L + +DV +I KIE V NFDEILK +
Sbjct: 199 LRFGVKNGVHMVFASFIRTANDVLTIREVLGEQ-GKDVKIIVKIENQQGVNNFDEILKVT 257
Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
DG+M+ARGDLG+E+P + +QK+LI K+N GKPVI ATQML SMT PTRAEV+D
Sbjct: 258 DGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSD 317
Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE---YRESFGMSRLRELVEDG 359
V NAILDG D VMLS ETA G +PI+AV MA+ A + E+ Y ++ +R
Sbjct: 318 VGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNY--DDMRNCTPKP 375
Query: 360 TRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNL 419
T T + ++ R + A+ K I+ + +G T RL+S+++P I + R
Sbjct: 376 T-STTETSLPR--VAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFS 432
Query: 420 MFSYGVYAFCLEE 432
GV+ F E+
Sbjct: 433 HLYRGVFPFVFEK 445
>pir||E83104 pyruvate kinase II PA4329 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950554|gb|AAG07717.1|AE004849_4
(AE004849) pyruvate kinase II [Pseudomonas aeruginosa]
Length = 483
Score = 261 bits (661), Expect = 9e-69
Identities = 173/481 (35%), Positives = 268/481 (54%), Gaps = 20/481 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKIVAT+GPA++S ++++LI G+ V RLNFSHG+ +EH VR+++ K R VA
Sbjct: 5 RTKIVATLGPASNSPEVLEQLILAGIDVARLNFSHGTPDEHRARARLVRELAAKHGRFVA 64
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDV--VGDETTIPVEYKDFPRLVSKGDV 127
+L DL G KIR+ + +EL+ G+K +T G + + ++Y D + GD
Sbjct: 65 LLGDLQGPKIRIAKFANKRIELQVGDKFRFSTSHARDAGTQEVVGIDYPDLVKDCGVGDE 124
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ L DG +V+ VEEV ++ V+ GG L KGIN L A+T +D IK A
Sbjct: 125 LLLDDGRVVMVVEEVAADELRCRVLIGGPLSDHKGINRRGGGLTAPALTDKDKADIKLAA 184
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKASDG 244
+ +D + +SF D+ + L + + ++++KIER +AV + D +++ASD
Sbjct: 185 DMDLDYVAVSFPRDAKDMEYARRLLTEAGGK-AWLVAKIERAEAVADDDALDGLIRASDA 243
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
+M+ARGDLGVE+ L +QK++I A K VITATQM+ SM +PTRAEV+DVA
Sbjct: 244 VMVARGDLGVEIGDAELVGIQKKIILHARRNNKVVITATQMMESMIHSPMPTRAEVSDVA 303
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMS-RLRELVEDGTRGT 363
NA+LD TDAVMLS E+A G++P++AVK MA++ + E++ S S RL + T
Sbjct: 304 NAVLDYTDAVMLSAESAAGEYPVEAVKAMARVCQGAEKHPTSQKSSHRLGQ-----TFDR 358
Query: 364 IKEAIA-RSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
E+IA S+ A IK I+ T +G T ++SR + I+ +S + +
Sbjct: 359 CDESIALASMYTANHFPGIKAIICLTESGFTPLIMSRIRSSVPIYAYSPHRETQARVAMF 418
Query: 423 YGVYAFCLE------EGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQ 476
GV + E + + L+K G+V D V++T+G GTN++K+
Sbjct: 419 RGVETIPFDPAALPAEKVSQAAVDELLK-RGVVTKGDWVILTKGDSYTAQGGTNTMKVLH 477
Query: 477 I 477
+
Sbjct: 478 V 478
>dbj|BAA88185.1| (AP000836) ESTs AU081247(C50004),AU068940(C51113) correspond to a
region of the predicted gene.~Similar to pyruvate kinase
(Q42954) [Oryza sativa]
Length = 507
Score = 260 bits (658), Expect = 2e-68
Identities = 157/398 (39%), Positives = 231/398 (57%), Gaps = 7/398 (1%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S MI +L+ G+ V R NFSHGS E H + ++ +R + A
Sbjct: 17 KTKIVCTLGPASRSVEMIGRLLRAGMCVARFNFSHGSHEYHQETLDNLRAAMESTGILCA 76
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G V+LK+G+++ ++T + GD+ I + YK + G V
Sbjct: 77 VMLDTKGPEIRTGFLKDGKPVQLKKGQEITVSTDYSIKGDDNMISMSYKKLAVDLKPGSV 136
Query: 128 IYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-IIK 184
I +DG I L V + V + L RK +N+P + + +T +D E I+K
Sbjct: 137 ILCADGTITLTVLHCDKEQGLVRCRCENTAMLGERKNVNLPGVIVDLPTLTEKDKEDILK 196
Query: 185 FAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDG 244
+ + +D I LSFV D+++V+ L K+ A+ + ++SK+E + V NFD+IL SD
Sbjct: 197 WGVPNKIDMIALSFVRKGSDLVEVRKVLGKH-AKSIMLMSKVENQEGVANFDDILAQSDA 255
Query: 245 IMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVA 304
M+ARGDLG+E+PIE++ QK +I K N +GKPV+TATQML SM PTRAE TDVA
Sbjct: 256 FMVARGDLGMEIPIEKIFYAQKVMIFKCNIQGKPVVTATQMLESMIKSPRPTRAEATDVA 315
Query: 305 NAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTI 364
NA+LDGTD VMLS ETA G +P AV+ MAKI E + + + +
Sbjct: 316 NAVLDGTDCVMLSGETAAGAYPELAVRTMAKICLQAESCVDHAAVFKSITASAPIPMSPL 375
Query: 365 KEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
E++A S + + IL TR G TARL+++++P
Sbjct: 376 -ESLASSAVRTANSAKAALILVLTRGGTTARLVAKYRP 412
>sp|P94685|KPYK_CHLTR PYRUVATE KINASE (PK) >gi|7434455|pir||G71527 probable pyruvate
kinase - Chlamydia trachomatis (serotype D, strain
UW3/Cx) >gi|3328751|gb|AAC67927.1| (AE001306) Pyruvate
Kinase [Chlamydia trachomatis]
Length = 485
Score = 259 bits (656), Expect = 4e-68
Identities = 154/419 (36%), Positives = 245/419 (57%), Gaps = 4/419 (0%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKI+ TIGPAT++ M++KL++ G++V RLNFSHG+ E H + I ++++ +K +A
Sbjct: 4 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLA 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKD--FPRLVSKGDV 127
I+ D G +IR+G+++ ++++ G+++ L +++++G + + Y FP + + V
Sbjct: 64 IMLDTKGPEIRLGQVESP-IKVQPGDRLTLVSKEILGSKESGVTLYPSCVFPYVRERAPV 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DGYI V + VE + G++ S K ++I + + +T +D+ +KF +
Sbjct: 123 L-IDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDIADLKFGV 181
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQ +D I SFV D+ ++ LE ++ +I+KIE V+NF EI +A+DGIMI
Sbjct: 182 EQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGIMI 241
Query: 248 ARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAI 307
ARGDLG+E+ I +P LQK + R + G+ ITATQML SM +PTRAEV+DVANAI
Sbjct: 242 ARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVANAI 301
Query: 308 LDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEA 367
DGT AVMLS ETA+G P+ AVK M I + TE+ + +L + EA
Sbjct: 302 YDGTSAVMLSGETALGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPYLEA 361
Query: 368 IARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVY 426
I S I + K I+ T+TG + +S+++P I + N V L +GVY
Sbjct: 362 IGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGVY 420
>sp|Q42954|KPYC_TOBAC PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|542061|pir||S41379 pyruvate
kinase (EC 2.7.1.40), cytosolic - common tobacco
>gi|444023|emb|CAA82628.1| (Z29492) pyruvate kinase
[Nicotiana tabacum]
Length = 508
Score = 258 bits (652), Expect = 1e-67
Identities = 161/405 (39%), Positives = 240/405 (58%), Gaps = 21/405 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S MI+KL+ G++V R NFSHGS + H + I+ +R + A
Sbjct: 19 KTKIVCTLGPASRSVPMIEKLLRAGMNVARFNFSHGSHDYHQETIDNLRQAMESTGILCA 78
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K V+LK+G+++ ++T + GDE+ I + YK V V
Sbjct: 79 VMLDTKGPEIRTGFLKDAKPVQLKQGQEITISTDYSIKGDESMICMSYKKLAEDVKPQSV 138
Query: 128 IYLSDGYI---VLRVEEVRGQD---VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME 181
I +DG I VL ++ G D E V G RK +N+P + + +T +D +
Sbjct: 139 ILCADGQITFTVLSCDKENGLDRCRCENTAVLG----ERKNVNLPGVIVDLPTLTDKDKD 194
Query: 182 -IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
I+ + + +D I LSFV D+++V+ L ++ A+++ ++SK+E + V NFD+IL
Sbjct: 195 DILNWGVPNHIDMIALSFVRKGSDLVEVRKLLGEH-AKNILLMSKVENQEGVANFDDILL 253
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
SD M+ARGDLG+E+PIE++ + QK +I K N +GKPV+TATQML SM PTRAE
Sbjct: 254 NSDAFMVARGDLGMEIPIEKIFLAQKVMIYKCNIQGKPVVTATQMLESMIKSPRPTRAEA 313
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVE 357
TDVANA+LDGTD VMLS ETA G +P AV MAKI A+ T +Y + F R +
Sbjct: 314 TDVANAVLDGTDCVMLSGETAAGAYPDLAVGTMAKICIEAESTIDYPDVF----KRIMSN 369
Query: 358 DGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S + + IL TR G TA+L+++++P
Sbjct: 370 APVPMSPLESLASSAVRTANSAKAALILVLTRGGSTAKLVAKYRP 414
>gi|6324923 pyruvate kinase; Pyk2p [Saccharomyces cerevisiae]
>gi|1730063|sp|P52489|KPY2_YEAST PYRUVATE KINASE 2
>gi|2117875|pir||S67256 probable pyruvate kinase (EC
2.7.1.40) YOR347c - yeast (Saccharomyces cerevisiae)
>gi|1199849|emb|CAA65034.1| (X95720) O6342
[Saccharomyces cerevisiae] >gi|1420756|emb|CAA99675.1|
(Z75255) ORF YOR347c [Saccharomyces cerevisiae]
Length = 506
Score = 257 bits (650), Expect = 2e-67
Identities = 163/468 (34%), Positives = 259/468 (54%), Gaps = 20/468 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEK-VRDISQKLDRRV 68
+T I+ TIGP T+S I L + G++++RLNFSHGS+E H VIE V+ Q R +
Sbjct: 22 RTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRPL 81
Query: 69 AILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDV----VGDETTIPVEYKDFPRLVSK 124
AI D G +IR G + ++ T D ++ + ++Y + +++
Sbjct: 82 AIALDTKGPEIRTGRTLNDQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVP 141
Query: 125 GDVIYLSDGYIVLRVEEVRGQ-DVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G IY+ DG + +V ++ + ++ V+ G + S KG+N+P + + ++ +DM+ +
Sbjct: 142 GRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDL 201
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
+F + G+ + SF+ + DVL ++ L ++ +D+ +ISKIE + NFDEIL+ +D
Sbjct: 202 QFGVRNGIHIVFASFIRTSEDVLSIRKALG-SEGQDIKIISKIENQQGLDNFDEILEVTD 260
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+MIARGDLG+E+ + +QK+LI K N GKPVI ATQML SMT PTRAEV+DV
Sbjct: 261 GVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDV 320
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGM-SRLRELVEDGTRG 362
NA+LDG D VMLS ETA G +P++AV +MA A + E + LR+ T
Sbjct: 321 GNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTST 380
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
T E +A + A+ + K I+ + TG TARL+S+++P I + + R
Sbjct: 381 T--ETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLY 438
Query: 423 YGVYAFCLE-EGFDE--RDIIRLIK-------GLGLVESDDIVLMTEG 460
GV+ F E + D+ D+ R +K G+V++ D V+ +G
Sbjct: 439 RGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQG 486
>sp|Q42806|KPYC_SOYBN PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|7434443|pir||T07787 pyruvate
kinase (EC 2.7.1.40) - soybean >gi|466350|gb|AAA17000.1|
(L08632) pyruvate kinase [Glycine max]
Length = 511
Score = 256 bits (647), Expect = 4e-67
Identities = 155/401 (38%), Positives = 233/401 (57%), Gaps = 13/401 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GPA+ S M +KL+ G++V R NFSHG+ + H + + ++ A
Sbjct: 22 KTKIVCTLGPASRSVEMTEKLLRAGMNVARFNFSHGTHDYHQETLNNLKTAMHNTGILCA 81
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G ++LK G++V +TT D+ GD I + YK P + G+
Sbjct: 82 VMLDTKGPEIRTGFLKDGKPIQLKEGQEVTITTDYDIKGDPEMISMSYKKLPVHLKPGNT 141
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVV-----SGGKLFSRKGINIPKAYLPVEAVTPRDME- 181
I SDG I L V D +A V + L RK +N+P + + +T +D E
Sbjct: 142 ILCSDGTITLTVLSC---DPDAGTVRCRCENTATLGERKNVNLPGVVVDLPTLTEKDKED 198
Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
I+ + + +D I LSFV D++ V+ L + A+++ ++SK+E + V NFDEIL+
Sbjct: 199 ILGWGVPNKIDMIALSFVRKGSDLVNVRKVLGPH-AKNIQLMSKVENQEGVLNFDEILRE 257
Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
+D M+ARGDLG+E+P+E++ + QK +I K N GKPV+TATQML SM PTRAE T
Sbjct: 258 TDAFMVARGDLGMEIPVEKIFLAQKMMIYKCNLVGKPVVTATQMLESMIKSPRPTRAEAT 317
Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR 361
DVANA+LDGTD VMLS E+A G +P AVK+MA+I + E +G +
Sbjct: 318 DVANAVLDGTDCVMLSGESAAGAYPELAVKIMARIC-IEAESSLDYGAIFKEMIRSTPLP 376
Query: 362 GTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S + K I+ TR G TA+L+++++P
Sbjct: 377 MSPLESLASSAVRTANKAKAKLIVVLTRGGSTAKLVAKYRP 417
>dbj|BAA95686.1| (AB042618) pyruvate kinase [Hydrogenophilus thermoluteolus]
Length = 473
Score = 254 bits (643), Expect = 1e-66
Identities = 170/472 (36%), Positives = 261/472 (55%), Gaps = 13/472 (2%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
TKIVAT+GPA+S +++L+ GV VVRLNFSHG+ +EH VR ++Q+ R V I
Sbjct: 4 TKIVATLGPASSDPATLERLLLAGVDVVRLNFSHGTADEHRARASLVRALAQQTQRPVGI 63
Query: 71 LADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPRLVSKGDVIYL 130
L DL G KIR+G V L +G++ L GD T + ++Y + V GD++ L
Sbjct: 64 LGDLQGPKIRIGRFTTNAVTLSKGQRFRLDCDLAPGDATRVGLDYPELIDDVEVGDILLL 123
Query: 131 SDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEI-IKFAIEQ 189
DG I L++ E + V+ GG L + KGIN L A+T +D + I ++ +
Sbjct: 124 DDGKIRLQIVEKCADALITQVLVGGTLSNHKGINKLGGGLSAPALTAKDRAVPISRSLPK 183
Query: 190 GVD-AIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
+ +SFV ++ + + L + +I+KIER +A+ N D IL+ASDG+M+A
Sbjct: 184 SASITVAVSFVKHAEEMHEARH-LARAAGSRARLIAKIERVEAIANLDAILEASDGVMVA 242
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDL VE+ +P LQK ++R+A + ITATQM+ SM VPTRAEV+DVANA+L
Sbjct: 243 RGDLAVEVGDAAVPALQKRILRRAREMNRLSITATQMMESMVHSPVPTRAEVSDVANAVL 302
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
DGTDAVMLS ETA G++P++AV+ MA++ + + + L + + + EAI
Sbjct: 303 DGTDAVMLSAETAAGQYPVEAVEAMARVCAEADASND----AHLDQELLGRRFHRVDEAI 358
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV--Y 426
A S + + L +K I+ T++G TA +SR I+ + + +L V
Sbjct: 359 AVSAVWSGYHLGVKAIVALTQSGATALWMSRIASILPIYALTPDPVTFGHLTLFRQVTPV 418
Query: 427 AFCLEEGFDERDIIRLIKGL----GLVESDDIVLMTEGKPIEKTMGTNSIKI 474
F L D ++ I+ L G + + +T G+P+ + G+N++KI
Sbjct: 419 RFDLNPASDPAMLLTQIRTLLVSNGWAAPGETIAVTFGEPMGQPGGSNTLKI 470
>pir||T47704 pyruvate kinase-like protein - Arabidopsis thaliana
>gi|7263553|emb|CAB81590.1| (AL161667) pyruvate
kinase-like protein [Arabidopsis thaliana]
Length = 510
Score = 252 bits (638), Expect = 5e-66
Identities = 151/405 (37%), Positives = 239/405 (58%), Gaps = 21/405 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKI+ T+GP + S MI+KL++ G++V R NFSHGS H + ++ +R A
Sbjct: 17 KTKIICTLGPVSRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGILSA 76
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G ++L +G+++ ++ ++ GD I + YK V GDV
Sbjct: 77 VMLDTKGPEIRTGFLKEGKPIQLNQGQEITISIDYMIEGDSNVISMSYKKLAEDVKPGDV 136
Query: 128 IYLSDGYI---VLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
I SDG I VL ++ G V + L RK +N+P + + +T +D E II
Sbjct: 137 ILCSDGTISLTVLSCDKSFGL-VRCRCENSAILGERKNVNLPGIVVDLPTLTEKDKEDII 195
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
++ + +D I LSFV D+ +V+ L ++ ++++ ++SK+E + V N ++IL+ SD
Sbjct: 196 QWGVPNKIDIIALSFVRKGSDLTEVRRLLGEH-SKNIMLMSKVENQEGVMNCEKILENSD 254
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
M+ARGDLG+E+PIE++ + QK +I+ AN GKPV+TATQML SMT PTRAE TDV
Sbjct: 255 AFMVARGDLGMEIPIEKMFLAQKTMIKMANALGKPVVTATQMLESMTVSPRPTRAEATDV 314
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
ANA+LDGTD VMLS ETA G P AV M++I K E++ + +++ T G
Sbjct: 315 ANAVLDGTDCVMLSGETAAGAHPEAAVLTMSRICKEAEDFID-------YDILHKKTLGM 367
Query: 364 IK------EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S++ ++ I+ T+ G TA L+++++P
Sbjct: 368 VSLPLSPIESLAASVVSTAQSVFASAIVVLTKGGYTAELVAKYRP 412
>pir||A82427 pyruvate kinase II VCA0708 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9658127|gb|AAF96607.1| (AE004400)
pyruvate kinase II [Vibrio cholerae]
Length = 486
Score = 252 bits (638), Expect = 5e-66
Identities = 167/480 (34%), Positives = 259/480 (53%), Gaps = 14/480 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIVAT+GPA+ +R + +LI+ GV+VVRLNFSHGS EEH E VR+I+Q+L+ V
Sbjct: 3 KTKIVATLGPASQTRETLTQLIQAGVNVVRLNFSHGSAEEHIARAEMVREIAQQLNVSVG 62
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDV 127
+L DL G KIR+ G ++L G+ +L G + + ++Y + ++ G++
Sbjct: 63 VLVDLQGPKIRIACFAEGAIQLSAGDTFILDGHLDGQAGTQERVGLDYPELIDDLNVGNI 122
Query: 128 IYLSDGYIVLRVEEVRGQD--VEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
+ L DG I L V V Q V + ++ GKL +RKGIN+ L A+T +D I
Sbjct: 123 LLLDDGRIQLEVTAVDMQARLVHTIALNSGKLSNRKGINLLGGGLSAPALTEKDKLDIIT 182
Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRN---FDEILKAS 242
A E D + +SF + D+ + + +++K+ER + V + D +++AS
Sbjct: 183 AAELQADFLAVSFPRNAEDIEYARQLATQAGCH-AHIVAKVERAEVVASEEAMDSVIRAS 241
Query: 243 DGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTD 302
D IM+ARGDLGVE+ RLP +QK LI +A GKPVITATQM+ SM +PTRAEV D
Sbjct: 242 DVIMVARGDLGVEIGDARLPSVQKALIARAKHLGKPVITATQMMESMIENPLPTRAEVLD 301
Query: 303 VANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRG 362
VANA++DGTDA+MLS E+A G++P++ V+ M +IA+ E E+ + ++
Sbjct: 302 VANAVIDGTDAIMLSAESAAGRYPVETVQAMVRIAQGVE--HETHCAQNCWDALQHLCSD 359
Query: 363 TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFS 422
K S+I A + T G T L+SR + + I+ S + L
Sbjct: 360 AGKSFALSSMISASKVNKDLGVAIVTEQGETPLLMSRCQSQATIWAVSDKPALLRKLAIL 419
Query: 423 YGV----YAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTNSIKIFQIA 478
GV + ++G +I L++ + +L+T+ + +E N ++ +A
Sbjct: 420 RGVTPTYFPHLDKQGDIATQLIHLLRKPAQEKKIASILVTQLESVEGVGHVNVCRLLNLA 479
>gb|AAB41226.1| (U83196) pyruvate kinase [Chlamydia trachomatis]
Length = 496
Score = 251 bits (634), Expect = 1e-65
Identities = 152/421 (36%), Positives = 242/421 (57%), Gaps = 8/421 (1%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKI+ TIGPAT++ M++KL++ G++V RLNFSHG+ E H + I ++++ +K +A
Sbjct: 15 RTKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLA 74
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETT----IPVEYKDFPRLVSKG 125
I+ D G +IR+G+++ ++++ G+++ L +++++G + + I V Y + R +
Sbjct: 75 IMLDTKGPEIRLGQVESP-IKVQPGDRLTLVSKEILGSKESALLFIQVVYSPYVR---ER 130
Query: 126 DVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKF 185
+ + DGYI V + VE + G++ S K ++I + + +T +D+ +KF
Sbjct: 131 APVLIDDGYIQAVVVNAQEHMVEIEFQNSGEIKSNKSLSIKDIDVALPFMTEKDIADLKF 190
Query: 186 AIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGI 245
+EQ +D I SFV D+ ++ LE ++ +I+KIE V+NF EI +A+DGI
Sbjct: 191 GVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGVQNFQEIARAADGI 250
Query: 246 MIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVAN 305
MIARGDLG+E+ I +P LQK + R + G+ ITATQML SM +PTRAEV+DVAN
Sbjct: 251 MIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRNPLPTRAEVSDVAN 310
Query: 306 AILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIK 365
AI DGT AVMLS ETA G P+ AVK M I + TE+ + +L +
Sbjct: 311 AIYDGTSAVMLSGETASGAHPVHAVKTMRSIIQETEKTFDYHAFFQLNDKNSALKVSPYL 370
Query: 366 EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGV 425
EA I + K I+ T+TG + +S+++P I + N V L +GV
Sbjct: 371 EANWVFWIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVTPNRNVYYRLAVEWGV 430
Query: 426 Y 426
Y
Sbjct: 431 Y 431
>sp|Q07637|KPYK_LACLA PYRUVATE KINASE >gi|421428|pir||B40620 pyruvate kinase (EC
2.7.1.40) - Lactococcus lactis subsp. lactis (strain
LM0230) >gi|308858|gb|AAA99895.1| (L07920) ATP:pyruvate
2-O-phosphotransferase [Lactococcus lactis]
Length = 502
Score = 247 bits (624), Expect = 2e-64
Identities = 165/500 (33%), Positives = 261/500 (52%), Gaps = 40/500 (8%)
Query: 10 KTKIVATIGPAT---------------------SSRNMIKKLIENGVSVVRLNFSHGSFE 48
+ KIV+T+GPA +S I LIE G +V R NFSHG
Sbjct: 4 RVKIVSTLGPAVEIRGGKKFGESGYWGESLDVEASAKNIAALIEEGANVFRFNFSHGDHP 63
Query: 49 EHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGY--VELKRGEKV-VLTTRDVV 105
E + V + +V L D G ++R G + + G+K V T + +
Sbjct: 64 EQGARMATVHRAEEIAGHKVGFLLDTKGPEMRTELFTDGADSISVVTGDKFRVATKQGLK 123
Query: 106 GDETTIPVEYK---DFPRLVSKGDVIYLSDGYIVLRV--EEVRGQDVEAVVVSGGKLFSR 160
I + D V G I + DG + L + ++ ++ E + G + +
Sbjct: 124 STPELIALNVAGGLDIFDDVEIGQTILIDDGKLGLSLTGKDAATREFEVEAQNDGVIGKQ 183
Query: 161 KGINIPKAYLPVEAVTPRDMEIIKFAIEQ--GVDAIGLSFVGSVYDVLKVKSFLEKNDAE 218
KG+NIP +P A+ RD I+F + Q G++ I +SFV + DV +V+ E+
Sbjct: 184 KGVNIPNTKIPFPALAERDDADIRFGLSQPGGINFIAISFVRTANDVKEVRRICEETGNP 243
Query: 219 DVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKP 278
V +++KIE + N DEI++A+DGIMIARGD+G+E+P E +P+ QK +I K N GK
Sbjct: 244 HVQLLAKIENQQGIENLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKLIISKVNKAGKI 303
Query: 279 VITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAK 338
V+TAT ML SMT TR+E++DV NA++DGTDA MLS E+A GK+P ++V+ MA + K
Sbjct: 304 VVTATNMLESMTYNPRATRSEISDVFNAVIDGTDATMLSGESANGKYPRESVRTMATVNK 363
Query: 339 VTEEYRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLIS 398
+ + +G R E + T+ E +A S+ +A +++K I+ T +G TARLIS
Sbjct: 364 NAQTMLKEYG----RLHPERYDKSTVTEVVAASVKNAAEAMDVKLIVALTESGNTARLIS 419
Query: 399 RFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIKGL----GLVESDDI 454
+ +P I + +E+V LM ++GV E+ D+ + + + GLVE+ D
Sbjct: 420 KHRPDADILAITFDEKVERGLMINWGVIPMMTEKPASTDDMFEVAEKVALASGLVEAGDN 479
Query: 455 VLMTEGKPIEKTMGTNSIKI 474
+++ G P+ T TN+++I
Sbjct: 480 IIIVAGVPV-GTGRTNTMRI 498
>gb|AAF44707.1| (AF242871) cytosolic pyruvate kinase [Lilium longiflorum]
Length = 510
Score = 244 bits (616), Expect = 2e-63
Identities = 151/402 (37%), Positives = 234/402 (57%), Gaps = 15/402 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTK+V T+GP++ S M++KL+ G++ R NFSHG+ E H + ++ +R Q A
Sbjct: 21 KTKLVCTLGPSSRSVPMLEKLLRAGMNTARFNFSHGTHEYHQETLDNLRIAMQNTQILCA 80
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G V+ K G++++++T D+ G TI + YK P + G
Sbjct: 81 VVLDTKGPEIRTGFLKDGKAVQPKEGQEIIVSTDYDLKGGGNTITMSYKKLPVDMKPGGT 140
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVV-----SGGKLFSRKGINIPKAYLPVEAVTPRDME- 181
I +DG I L V D +A V + L RK +N+P + + +T +D E
Sbjct: 141 ILCADGSISLTVLSC---DPDAGTVRCRCENTALLGERKNVNLPGVVVDLPTLTEKDKED 197
Query: 182 IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKA 241
I+++ + +D I LSFV D++ V+ L + A+++ ++SK+E + V NFDEILK
Sbjct: 198 ILEWGVPNNIDMIALSFVRKGSDLVNVRQVLGSH-AKNIKLMSKVENQEGVVNFDEILKE 256
Query: 242 SDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVT 301
+D M+ARGDLG+E+P+E++ + QK +I N GKPV+TATQML SM PTRAE T
Sbjct: 257 TDAFMVARGDLGMEIPVEKIFLAQKLMIYICNLAGKPVVTATQMLESMIKSPRPTRAEAT 316
Query: 302 DVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTR 361
DVANA+LDGTD VMLS E+A G + AVK+MAKI E + + +E++
Sbjct: 317 DVANAVLDGTDCVMLSGESAAGAYLEIAVKVMAKICIEAESSLDYDAI--FKEMIRSAPL 374
Query: 362 G-TIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S + I+ TR G TA+L+++++P
Sbjct: 375 PMSPLESLASSAVRTANKAKAALIVVLTRGGTTAKLVAKYRP 416
>sp|P22200|KPYC_SOLTU PYRUVATE KINASE, CYTOSOLIC ISOZYME >gi|100463|pir||S12248 pyruvate
kinase (EC 2.7.1.40) - potato >gi|22576|emb|CAA37727.1|
(X53688) pyruvate kinase [Solanum tuberosum]
Length = 510
Score = 243 bits (615), Expect = 2e-63
Identities = 147/404 (36%), Positives = 237/404 (58%), Gaps = 11/404 (2%)
Query: 5 RLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL 64
R+P KTKIV T+GP++ + M++KL+ G++V R NFSHG+ E H + ++ ++ Q
Sbjct: 18 RIP--KTKIVCTLGPSSRTVPMLEKLLRAGMNVARFNFSHGTHEYHQETLDNLKIAMQNT 75
Query: 65 DRRVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLV 122
A++ D G +IR G + G ++LK G+++ ++T + G+E I + YK +
Sbjct: 76 QILCAVMLDTKGPEIRTGFLTDGKPIQLKEGQEITVSTDYTIKGNEEMISMSYKKLVMDL 135
Query: 123 SKGDVIYLSDGYIVLRVE--EVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
G+ I +DG I L V + V + L RK +N+P + + +T +D
Sbjct: 136 KPGNTILCADGTITLTVLSCDPPSGTVRCRCENTATLGERKNVNLPGVVVDLPTLTEKDK 195
Query: 181 E-IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEIL 239
E I+++ + +D I LSFV D++ V+ L + A+ + ++SK+E + V NFDEIL
Sbjct: 196 EDILEWGVPNNIDMIALSFVRKGSDLVNVRKVLGPH-AKRIQLMSKVENQEGVINFDEIL 254
Query: 240 KASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAE 299
+ +D M+ARGDLG+E+P+E++ + QK +I K N GK V+TATQML SM PTRAE
Sbjct: 255 RETDSFMVARGDLGMEIPVEKIFLAQKMMIYKCNLAGKAVVTATQMLESMIKSPAPTRAE 314
Query: 300 VTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVE-D 358
TDVANA+LDGTD VMLS E+A G +P AVK+M++I E ++ + +E++
Sbjct: 315 ATDVANAVLDGTDCVMLSGESAAGAYPELAVKIMSRICIEAESSLDNEAI--FKEMIRCT 372
Query: 359 GTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S + K I+ TR G TA+L+++++P
Sbjct: 373 PLPMSPLESLASSAVRTANKARAKLIVVLTRGGSTAKLVAKYRP 416
>pir||JC1481 pyruvate kinase (EC 2.7.1.40), cytosolic - potato
Length = 510
Score = 242 bits (611), Expect = 7e-63
Identities = 147/404 (36%), Positives = 237/404 (58%), Gaps = 11/404 (2%)
Query: 5 RLPDHKTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKL 64
R+P KTKIV T+GP++ + M++KL+ G++V R NFSHG+ E H + ++ ++ Q
Sbjct: 18 RIP--KTKIVCTLGPSSRTVPMLEKLLRAGMNVARFNFSHGTHEYHQETLDNLKIAMQNT 75
Query: 65 DRRVAILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVV-GDETTIPVEYKDFPRLV 122
A++ D G +IR G + G ++LK G+++ ++T + G+E I + YK +
Sbjct: 76 QILCAVMLDTKGPEIRTGFLTDGKPIQLKEGQEITVSTDYTIKGNEEMISMSYKKLVVDL 135
Query: 123 SKGDVIYLSDGYIVLRVE--EVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
G+ I +DG I L V + V + L RK +N+P + + +T +D
Sbjct: 136 KPGNTILCADGTITLTVLSCDPPSGTVRCRCENSATLGERKNVNLPGVVVDLPTLTEKDK 195
Query: 181 E-IIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEIL 239
E I+++ + +D I LSFV D++ V+ L + A+ + ++SK+E + V NFDEIL
Sbjct: 196 EDILEWGVPNNIDMIALSFVRKGSDLVNVRKALGPH-AKRIQLMSKVENQEGVINFDEIL 254
Query: 240 KASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAE 299
+ +D M+ARGDLG+E+P+E++ + QK +I K N GK V+TATQML SM PTRAE
Sbjct: 255 RETDSFMVARGDLGMEIPVEKIFLAQKMMIYKCNLAGKAVVTATQMLESMIKSPRPTRAE 314
Query: 300 VTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVE-D 358
TDVANA+LDGTD VMLS E+A G +P AVK+M++I E ++ + +E++
Sbjct: 315 ATDVANAVLDGTDCVMLSGESAAGAYPELAVKIMSRICIEAESSLDNEAI--FKEMIRCT 372
Query: 359 GTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S + K I+ TR G TA+L+++++P
Sbjct: 373 PLPMSPLESLASSAVRTANKARAKLIVVLTRGGSTAKLVAKYRP 416
>sp|P31865|KPYK_TRIRE PYRUVATE KINASE >gi|484468|pir||JN0780 pyruvate kinase (EC
2.7.1.40) - fungus (Trichoderma reesei)
>gi|170553|gb|AAA02922.1| (L07060) pyruvate kinase
[Hypocrea jecorina]
Length = 538
Score = 241 bits (609), Expect = 1e-62
Identities = 162/488 (33%), Positives = 258/488 (52%), Gaps = 29/488 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVR-DISQKLDRRV 68
+T I+ TIGP T+S + KL + G++V R+NFSHGS+E H VI+ VR ++ R V
Sbjct: 43 RTSIICTIGPKTNSVEALNKLRDAGLNVARMNFSHGSYEYHQSVIDNVRASVAAHPGRPV 102
Query: 69 AILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTRDVVG---DETTIPVEYKDFPRLVSK 124
AI D G +IR G G + + G + TT + D + V+YK+ +++
Sbjct: 103 AIALDTKGPEIRTGNTAGDVDIPISAGTVMNFTTDEKYATACDTQNMYVDYKNITKVIQP 162
Query: 125 GDVIYLSDGYIVLRVEEVRG-QDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEII 183
G VIY+ DG + V ++ Q VE + G + SRKG+N+P + + A++ +D +
Sbjct: 163 GRVIYVDDGVLAFDVLSIKDDQTVEVRARNNGFISSRKGVNLPNTDVDLPALSEKDKADL 222
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
+F ++ VD + SF+ D+ ++ L + + + +I+KIE + NF EIL+ +D
Sbjct: 223 RFGVKNNVDMVFASFIRRAQDIKDIRDVLGP-EGKQIQIIAKIENRQGLNNFAEILEETD 281
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
G+M+ARGDLG+E+P + QK++I N GKPVI ATQML SM PTRAE++DV
Sbjct: 282 GVMVARGDLGIEIPAAEVFAAQKKMIAMCNIAGKPVICATQMLESMIKNPRPTRAEISDV 341
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI---AKVTEEYRESFGMSRLRELVEDGT 360
NA+ DG D VMLS ETA G +P +++ M + A+ T Y F + LV+
Sbjct: 342 GNAVTDGADCVMLSGETAKGNYPAESIHEMHEASLKAENTIPYVSHF--EEMCTLVKRPV 399
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
+ E+ A + + A L I+ + +G +ARL+S+++P IF + N
Sbjct: 400 --STVESCAMAAVRASLDLGAGGIIVLSTSGDSARLLSKYRPVCPIFMVTRNPTTSRFSH 457
Query: 421 FSYGVYAFCLEE---GFD----ERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMG----- 468
GVY F E FD + D+ + IK + + ++ +T G + G
Sbjct: 458 LYRGVYPFLYPEQKPDFDTVNWQEDVDKRIK-WAVTRAIELKTLTAGDTVVVVQGWKGGM 516
Query: 469 --TNSIKI 474
TN+++I
Sbjct: 517 GNTNTLRI 524
>pir||A72119 pyruvate kinase CP0677 [imported] - Chlamydophila pneumoniae
(strains CWL029 and AR39) >gi|4376358|gb|AAD18250.1|
(AE001596) Pyruvate Kinase [Chlamydophila pneumoniae
CWL029] >gi|7189591|gb|AAF38488.1| (AE002225) pyruvate
kinase [Chlamydophila pneumoniae AR39]
Length = 484
Score = 238 bits (601), Expect = 1e-61
Identities = 156/464 (33%), Positives = 253/464 (53%), Gaps = 10/464 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKI+ TIGPAT+S M+ KL++ G++V RLNFSHGS E H + I ++++ ++ +A
Sbjct: 4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLA 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGD-ETTIPVEYKDFPRLVSKGDVI 128
I+ D G +IR+G I + + +G+K+ L + D+ G E + + K V +G +
Sbjct: 64 IMLDTKGPEIRLGNIPQP-ISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPFVPEGADV 122
Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
+ DGYI V +E ++ G L S K ++I + + +T +D+ +KF +E
Sbjct: 123 LIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIRGVDVALPFMTEKDIADLKFGVE 182
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
Q +D + SFV D+ ++ L + +I+KIE V NF +I K +DGIMIA
Sbjct: 183 QNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIMIA 242
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLG+E+ + +P LQK + + + G +TATQML SM +PTRAEV+D+ANAI
Sbjct: 243 RGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIY 302
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
DG+ AVMLS ETA G P+ AVK+M + TE+ +L + AI
Sbjct: 303 DGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSPYLSAI 362
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
+ I + K ++ T +G + +S+++PK I + + V L +GVY
Sbjct: 363 GLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPM 422
Query: 429 CLEEGFDERDIIR---LIKGL--GLVES-DDIVLMTEGKPIEKT 466
+E +R + R I G+ G++ + D I++++ G +E+T
Sbjct: 423 LTQE--SDRAVWRHQACIYGIEQGILSNYDRILVLSRGACMEET 464
>sp|Q40545|KPYA_TOBAC PYRUVATE KINASE ISOZYME A, CHLOROPLAST PRECURSOR
>gi|482936|emb|CAA82222.1| (Z28373) pyruvate kinase;
plastid isozyme [Nicotiana tabacum]
Length = 593
Score = 236 bits (597), Expect = 3e-61
Identities = 152/468 (32%), Positives = 252/468 (53%), Gaps = 25/468 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TK++ TIGPAT +++L E G++V R+N HG+ E H VIE++R ++++ VA
Sbjct: 115 RTKLICTIGPATCGFEQLERLAEGGMNVARINMCHGTREWHRMVIERLRRLNEEKGFAVA 174
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGD 126
I+ D G +I +G++ G + + GE T R D E T+ V Y F V GD
Sbjct: 175 IMMDTEGSEIHMGDLGGASSAKAEDGEIWNFTVRSFDPPLPERTVTVNYDGFAEDVKVGD 234
Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKL-------FSRKGINIPKAYLPVEAVTPRD 179
+ + G + V E G DV+ + G L F R G + + + ++ +D
Sbjct: 235 ELLVDGGMVRFEVIEKIGPDVKCLCTDPGLLLPRANLTFWRDGKLVRERNAMLPTISSKD 294
Query: 180 MEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEI 238
I F I +GVD I +SFV S + +KS+++ + D+ VI+KIE D+++N +EI
Sbjct: 295 WLDIDFGIAEGVDFIAVSFVKSAEVIKHLKSYIQARARDSDISVIAKIESIDSLKNLEEI 354
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
++ASDG M+ARGDLG ++P+E++P Q+++++ +PVI A+Q+L SM +PTRA
Sbjct: 355 IQASDGAMVARGDLGAQIPLEQVPSEQQKIVQICRQLNRPVIVASQLLESMIEYPIPTRA 414
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIA-KVTEEYRESFGMSRLRELVE 357
EV DV+ A+ DA+MLS E+A+G+FP A+ ++ ++ ++ +RE + E++E
Sbjct: 415 EVADVSEAVRQRGDALMLSGESAMGQFPEKALTVLRSVSLRIERMWRE----QKRHEVIE 470
Query: 358 -----DGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTN 412
+I E I S L + + T+ G A L+SR +P IF F+T
Sbjct: 471 LPSIASSFSDSISEEICNSAAKMANNLEVDALFVYTKNGHMASLLSRCRPDCPIFAFTTT 530
Query: 413 ERVCNNLMFSYGVYAFCLEEGFDERDIIR----LIKGLGLVESDDIVL 456
V L +G+ F L D + L+K G+++S D+++
Sbjct: 531 TSVRRRLNLQWGLMPFRLSFSDDMESNLNKTFSLLKARGMIKSGDLII 578
>pir||S51946 pyruvate kinase (EC 2.7.1.40) A, chloroplast - common tobacco
Length = 593
Score = 236 bits (597), Expect = 3e-61
Identities = 152/468 (32%), Positives = 252/468 (53%), Gaps = 25/468 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TK++ TIGPAT +++L E G++V R+N HG+ E H VIE++R ++++ VA
Sbjct: 115 RTKLICTIGPATCGFEQLERLAEGGMNVARINMCHGTREWHRMVIERLRRLNEEKGFAVA 174
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGD 126
I+ D G +I +G++ G + + GE T R D E T+ V Y F V GD
Sbjct: 175 IMMDTEGSEIHMGDLGGASSAKAEDGEIWNFTVRSFDPPLPERTVTVNYDGFAEDVKVGD 234
Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKL-------FSRKGINIPKAYLPVEAVTPRD 179
+ + G + V E G DV+ + G L F R G + + + ++ +D
Sbjct: 235 ELLVDGGMVRFEVIEKIGPDVKCLCTDPGLLLPRANLTFWRDGKLVRERNAMLPTISSKD 294
Query: 180 MEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEI 238
I F I +GVD I +SFV S + +KS+++ + D+ VI+KIE D+++N +EI
Sbjct: 295 WLDIDFGIAEGVDFIAVSFVKSAEVIKHLKSYIQARARDSDISVIAKIESIDSLKNLEEI 354
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
++ASDG M+ARGDLG ++P+E++P Q+++++ +PVI A+Q+L SM +PTRA
Sbjct: 355 IQASDGAMVARGDLGAQIPLEQVPSEQQKIVQICRQLNRPVIVASQLLESMIEYPIPTRA 414
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIA-KVTEEYRESFGMSRLRELVE 357
EV DV+ A+ DA+MLS E+A+G+FP A+ ++ ++ ++ +RE + E++E
Sbjct: 415 EVADVSEAVRQRGDALMLSGESAMGQFPEKALTVLRSVSLRIERMWRE----QKRHEVIE 470
Query: 358 -----DGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTN 412
+I E I S L + + T+ G A L+SR +P IF F+T
Sbjct: 471 LPSIASSFSDSISEEICNSAAKMANNLEVDALFVYTKNGHMASLLSRCRPDCPIFAFTTT 530
Query: 413 ERVCNNLMFSYGVYAFCLEEGFDERDIIR----LIKGLGLVESDDIVL 456
V L +G+ F L D + L+K G+++S D+++
Sbjct: 531 TSVRRRLNLQWGLMPFRLSFSDDMESNLNKTFSLLKARGMIKSGDLII 578
>dbj|BAA98307.1| (AP002545) pyruvate kinase [Chlamydophila pneumoniae J138]
Length = 484
Score = 236 bits (595), Expect = 5e-61
Identities = 156/464 (33%), Positives = 252/464 (53%), Gaps = 10/464 (2%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKI+ TIGPAT+S M+ KL++ G++V RLNFSHGS E H + I ++++ ++ +A
Sbjct: 4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLA 63
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGD-ETTIPVEYKDFPRLVSKGDVI 128
I+ D G +IR+G I + + +G+K+ L + D+ G E + + K V +G +
Sbjct: 64 IMLDTKGPEIRLGNIPQP-ISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPFVPEGADV 122
Query: 129 YLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAIE 188
+ DGYI V +E ++ G L S K ++I + + +T +D+ +KF +E
Sbjct: 123 LIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIRGVDVALPFMTEKDIADLKFGVE 182
Query: 189 QGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMIA 248
Q +D SFV D+ ++ L + +I+KIE V NF +I K +DGIMIA
Sbjct: 183 QNMDVNAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIMIA 242
Query: 249 RGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAIL 308
RGDLG+E+ + +P LQK + + + G +TATQML SM +PTRAEV+D+ANAI
Sbjct: 243 RGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIY 302
Query: 309 DGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGTIKEAI 368
DG+ AVMLS ETA G P+ AVK+M + TE+ +L + AI
Sbjct: 303 DGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSPYLSAI 362
Query: 369 ARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAF 428
+ I + K ++ T +G + +S+++PK I + + V L +GVY
Sbjct: 363 GLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPM 422
Query: 429 CLEEGFDERDIIR---LIKGL--GLVES-DDIVLMTEGKPIEKT 466
+E +R + R I G+ G++ + D I++++ G +E+T
Sbjct: 423 LTQE--SDRAVWRHQACIYGIEQGILSNYDRILVLSRGACMEET 464
>sp|P55964|KPYG_RICCO PYRUVATE KINASE ISOZYME G, CHLOROPLAST
Length = 418
Score = 235 bits (594), Expect = 7e-61
Identities = 156/424 (36%), Positives = 235/424 (54%), Gaps = 16/424 (3%)
Query: 61 SQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDETTIPVEYKDFPR 120
+Q D V+I+ D G ++R G++ LK G++ T R V + T+ V Y DF
Sbjct: 2 AQSHDNVVSIMLDTKGPEVRSGDVPQPM--LKEGQEFNPTIRRGVSTQDTVSVNYDDFVN 59
Query: 121 LVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDM 180
V GD++ + G + L V+ V+ VVV GG+L SR+ +N+ + ++T +D
Sbjct: 60 DVVVGDILLVDGGMMSLAVKSKTSDLVKCVVVDGGELKSRRHLNVRGKSARLPSITDKDW 119
Query: 181 EIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILK 240
IKF ++ VD +SFV V ++K +L++ +A D+ VI KIE D++ N I+
Sbjct: 120 GDIKFGVDNQVDFYAVSFVKDAKVVHELKEYLKRCNA-DIHVIVKIESADSIPNLHSIIS 178
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
ASDG M+ARGDLG E+PIE +P+LQ+++IR+ ++ KPVI AT ML SM PTRAEV
Sbjct: 179 ASDGAMVARGDLGAELPIEEVPLLQEDIIRRCHSMQKPVIVATNMLESMINHPTPTRAEV 238
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
+D+A A+ +G DAVMLS ETA GK+P+ AV++M +A T ES +
Sbjct: 239 SDIAIAVREGADAVMLSGETAHGKYPLKAVRVMHTVALRT----ESSSPVNTTPPAQGAY 294
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
+G + E A TLN I+ TRTG A L+S ++P IF F+ ER+ L
Sbjct: 295 KGHMGEMFAFHATIMANTLNTP-IIVFTRTGSMAVLLSHYQPASTIFAFTNEERIKQRLS 353
Query: 421 FSYGV------YAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEG-KPIEKTMGTNSIK 473
GV ++ EE F + L KGL LVE + + L+ G +PI + T+ I+
Sbjct: 354 LYRGVMPIYMEFSSDAEETFSRALQLLLNKGL-LVEGEHVTLVQSGAQPIWRQESTHHIQ 412
Query: 474 IFQI 477
+ ++
Sbjct: 413 VRKV 416
>sp|Q43117|KPYA_RICCO PYRUVATE KINASE ISOZYME A, CHLOROPLAST PRECURSOR
>gi|7434456|pir||T10051 pyruvate kinase (EC 2.7.1.40) -
castor bean >gi|169703|gb|AAA33870.1| (M64736)
ATP:pyruvate phosphotransferase [Ricinus communis]
Length = 583
Score = 235 bits (592), Expect = 1e-60
Identities = 154/464 (33%), Positives = 243/464 (52%), Gaps = 17/464 (3%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TK+V TIGPAT ++ L G++V R+N HG+ E H VIE+VR ++++ VA
Sbjct: 105 RTKLVCTIGPATCGFEELEALAVGGMNVARINMCHGTREWHKSVIERVRRLNEEKGFAVA 164
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGD 126
I+ D G +I +G++ G + + GE + R D E TI V Y F V GD
Sbjct: 165 IMMDTEGSEIHMGDLGGASSAKAEDGEIWTFSVRAYDSPRPERTINVNYDGFAEDVKVGD 224
Query: 127 VIYLSDGYIVLRVEEVRGQDVEAVVVSGGKL-------FSRKGINIPKAYLPVEAVTPRD 179
+ + G + V E G DV+ G L F R G + + + ++ +D
Sbjct: 225 ELLVDGGMVRFEVIEKIGPDVKCRCTDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKD 284
Query: 180 MEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEI 238
I F I +GVD I +SFV S + +KS++ + D+ VI+KIE D+++N +EI
Sbjct: 285 WLDIDFGIAEGVDFIAISFVKSAEVINHLKSYIAARSRDSDIAVIAKIESIDSLKNLEEI 344
Query: 239 LKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRA 298
++ASDG M+ARGDLG ++P+E++P Q+ +++ KPVI A+Q+L SM PTRA
Sbjct: 345 IRASDGAMVARGDLGAQIPLEQVPSAQQNIVQVCRQLNKPVIVASQLLESMIEYPTPTRA 404
Query: 299 EVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVED 358
EV DV+ A+ DA+MLS E+A+G++P A+ ++ ++ E++ EL
Sbjct: 405 EVADVSEAVRQRADALMLSGESAMGQYPEKALAVLRSVSVRIEKWWREEKHHEAMELPAI 464
Query: 359 GT--RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVC 416
G+ +I E I S L + + T+ G A L+SR +P IF F+T V
Sbjct: 465 GSTYSDSISEEICNSAAKMANNLGVDALFVYTKDGHMASLLSRCRPDCPIFAFTTTTSVR 524
Query: 417 NNLMFSYGVYAFCLEEGFDERDIIR----LIKGLGLVESDDIVL 456
L +G+ F L D + L+K G+++S D+V+
Sbjct: 525 RRLNLQWGLIPFRLSFADDMESNLNKTFSLLKARGMIKSGDLVI 568
>gb|AAA27629.1| (M98350) pyruvate kinase-like protein [unidentified bacterium]
Length = 391
Score = 234 bits (590), Expect = 2e-60
Identities = 139/375 (37%), Positives = 215/375 (57%), Gaps = 10/375 (2%)
Query: 106 GDETTIPVEYKDFPRLVSKGDVIYLSDGYIVLRV--EEVRGQDVEAVVVSGGKLFSRKGI 163
G + I V Y V G + DG + V ++V +++ V + G L SRKG+
Sbjct: 18 GTKEKIAVTYAGLFDDVQVGGQVLFDDGLLGTTVLEKDVANRELVVRVDNDGILGSRKGV 77
Query: 164 NIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVI 223
N P + + +T +D + I+F ++ G++ I SFV DVL+++ L++ + E V ++
Sbjct: 78 NAPGVSINLPGITEKDADDIRFGLDHGINYIAASFVRKPEDVLEIRGLLKEKNMEHVQIV 137
Query: 224 SKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITAT 283
KIE + + N D I+ SDG+M+ RGD+GVE+P E +P++QKE+IRK N G PVITAT
Sbjct: 138 PKIESQEGIDNLDAIIAVSDGLMVPRGDMGVEIPAENVPLVQKEMIRKMNLAGLPVITAT 197
Query: 284 QMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEY 343
QML SM PTRAE +DVANA+ DGTDA MLS E+A G++P++AV MA I + E
Sbjct: 198 QMLDSMEENPRPTRAEASDVANAVFDGTDATMLSGESANGEYPVEAVATMAAIDEKAESS 257
Query: 344 RESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPK 403
+G R ++L D T T EA+A ++ ++N K I+ T +G TA ++S+++P+
Sbjct: 258 LPYYG--RHQDLHFDETDST--EAVASAVSRIAHSVNAKAIVVSTNSGYTACMVSKYRPE 313
Query: 404 QWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRL----IKGLGLVESDDIVLMTE 459
I + +ERV L +YGV E ++I L +K GL S D +++
Sbjct: 314 VNILAVTYSERVQRGLTLNYGVLPVVYEAPATIDEMIALAKTAVKEQGLANSGDTIVIAA 373
Query: 460 GKPIEKTMGTNSIKI 474
G P+ ++ TN I +
Sbjct: 374 GVPMSQSGTTNMITV 388
>sp|P47458|KPYK_MYCGE PYRUVATE KINASE (PK) >gi|1361781|pir||H64223 pyruvate kinase (EC
2.7.1.40) - Mycoplasma genitalium
>gi|3844816|gb|AAC71435.1| (U39701) pyruvate kinase
(pyk) [Mycoplasma genitalium]
Length = 508
Score = 219 bits (551), Expect = 7e-56
Identities = 150/479 (31%), Positives = 254/479 (52%), Gaps = 47/479 (9%)
Query: 8 DH--KTKIVATIGPATSSRNM--------------------IKKLIENGVSVVRLNFSHG 45
DH +TKI+AT GPA + + I+ +I++GVSV+RLNFSHG
Sbjct: 3 DHLKRTKIIATCGPALTKSLVSLKMLDDNEYAAIKKVAYANIEAIIKSGVSVIRLNFSHG 62
Query: 46 SFEEHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRD-V 104
+ EE I+ VRD+++ ++ V+I+ D G +IR+ E K +++ + +V++ T +
Sbjct: 63 THEEQQVRIKIVRDVAKAMNIPVSIMLDTNGPEIRIVETKKEGLKITKDSEVIINTMSKM 122
Query: 105 VGDETTIPVEYK----DFPRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVVVSGGK--LF 158
+ + V + V+ G I + DG + L V V Q + + V+ +F
Sbjct: 123 IASDNQFAVSDASGKYNMVNDVNIGQKILVDDGKLTLVVTRVDKQHNQVICVAKNDHTVF 182
Query: 159 SRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAE 218
++K +N+P A + ++ +D++ I F + QG+D I SFV +V D+ +++ +L+ +A
Sbjct: 183 TKKRLNLPNAQYSIPFLSEKDLKDIDFGLSQGIDYIAASFVNTVADIKQLRDYLKLKNAS 242
Query: 219 DVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKP 278
V +I+KIE A+ N D+I+KASDGIM+ARGDLG+E+P ++P Q+ +I+ K
Sbjct: 243 GVKIIAKIESNHALNNIDKIIKASDGIMVARGDLGLEIPYYQVPYWQRYMIKACRFFNKR 302
Query: 279 VITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAK 338
ITATQML S+ PTRAEVTDV A+ G DA MLS ETA G +P++AV +M KI K
Sbjct: 303 SITATQMLDSLEKNIQPTRAEVTDVYFAVDRGNDATMLSGETASGLYPLNAVAVMQKIDK 362
Query: 339 VTEEY------------RESFGMSRL-RELVEDGTRGTIKEAIARSIIDALCTLNIKYIL 385
+E + + SR +V T+ T+ + R ++++ +I+
Sbjct: 363 QSETFFDYQYNVNYYLKNSTANKSRFWHNVVLPLTKKTVPK---RKLVNS--AFKYDFIV 417
Query: 386 TPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIK 444
PT +S + + + N+RV YG++ + +++ ++ LI+
Sbjct: 418 YPTNNINRIYALSNARLAAAVIILTNNKRVYTGHGVDYGIFCYLIDKNPNQLTKAELIE 476
>pir||T47720 pyruvate kinase-like protein - Arabidopsis thaliana
>gi|7263569|emb|CAB81606.1| (AL161667) pyruvate
kinase-like protein [Arabidopsis thaliana]
Length = 492
Score = 218 bits (550), Expect = 1e-55
Identities = 142/405 (35%), Positives = 226/405 (55%), Gaps = 39/405 (9%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV T+GP + S MI+KL++ A+ ++ +R A
Sbjct: 17 KTKIVCTLGPVSRSVEMIEKLLK------------------AETLDNLRTAMNNTGILCA 58
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTTR-DVVGDETTIPVEYKDFPRLVSKGDV 127
++ D G +IR G +K G ++L +G+++ ++ + GD I + YK V GDV
Sbjct: 59 VMLDTKGPEIRTGFLKEGKPIQLNQGQEITISIDYKIEGDSNIISMSYKKLAEDVKPGDV 118
Query: 128 IYLSDGYI---VLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDME-II 183
I SDG I VL ++ G V + L RK +N+P + + +T +D E II
Sbjct: 119 ILCSDGTISLTVLSCDKSFGL-VRCRCENSTILGERKNVNLPGIVVDLPTLTEKDKEDII 177
Query: 184 KFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASD 243
++ + +D I LSFV D+ +V+ L ++ ++++ ++SK+E + V N ++IL+ SD
Sbjct: 178 QWGVPNKIDIIALSFVRKGSDLTEVRKLLGEH-SKNIMLMSKVENQEGVMNCEKILENSD 236
Query: 244 GIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDV 303
M+ARGDLG+E+ IE++ + QK +I+ AN GKPV+TATQML SMT PTRAE TDV
Sbjct: 237 AFMVARGDLGMEIQIEKMFLAQKTMIKMANALGKPVVTATQMLESMTVSPRPTRAEATDV 296
Query: 304 ANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGTRGT 363
ANA+LDGTD VMLS ETA G P AV M++I K E++ + +++ T G
Sbjct: 297 ANAVLDGTDCVMLSGETAAGAHPEAAVLTMSRICKEAEDFID-------YDILHKKTLGM 349
Query: 364 IK------EAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKP 402
+ E++A S++ ++ I+ T+ G TA L+++++P
Sbjct: 350 LSLPLSPIESLAASVVSTAQSVFASAIVVLTKGGYTAELVAKYRP 394
>pir||T10054 pyruvate kinase (EC 2.7.1.40) isoform beta - castor bean
>gi|169705|gb|AAA33871.1| (M64737) ATP:pyruvate
phosphotransferase [Ricinus communis]
Length = 493
Score = 214 bits (540), Expect = 1e-54
Identities = 143/439 (32%), Positives = 228/439 (51%), Gaps = 17/439 (3%)
Query: 35 VSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGY-VELKR 93
++V R+N HG+ E H VIE+VR ++++ VAI+ D G +I +G++ G + +
Sbjct: 40 MNVARINMCHGTREWHKSVIERVRRLNEEKGFAVAIMMDTEGSEIHMGDLGGASSAKAED 99
Query: 94 GEKVVLTTR--DVVGDETTIPVEYKDFPRLVSKGDVIYLSDGYIVLRVEEVRGQDVEAVV 151
GE + R D E TI V Y F V GD + + G + V E G DV+
Sbjct: 100 GEIWTFSVRAYDSPRPERTINVNYDGFAEDVKVGDELLVDGGMVRFEVIEKIGPDVKCRC 159
Query: 152 VSGGKL-------FSRKGINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYD 204
G L F R G + + + ++ +D I F I +GVD I +SFV S
Sbjct: 160 TDPGLLLPRANLTFWRDGSLVRERNAMLPTISSKDWLDIDFGIAEGVDFIAISFVKSAEV 219
Query: 205 VLKVKSFLEKNDAE-DVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPI 263
+ +KS++ + D+ VI+KIE D+++N +EI++ASDG M+ARGDLG ++P+E++P
Sbjct: 220 INHLKSYIAARSRDSDIAVIAKIESIDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPS 279
Query: 264 LQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIG 323
Q+ +++ KPVI A+Q+L SM PTRAEV DV+ A+ DA+MLS E+A+G
Sbjct: 280 AQQNIVQVCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSGESAMG 339
Query: 324 KFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT--RGTIKEAIARSIIDALCTLNI 381
++P A+ ++ ++ E++ EL G+ +I E I S L +
Sbjct: 340 QYPEKALAVLRSVSVRIEKWWREEKHHEAMELPAIGSTYSDSISEEICNSAAKMANNLGV 399
Query: 382 KYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIR 441
+ T+ G A L+SR +P IF F+T V L +G+ F L D +
Sbjct: 400 DALFVYTKDGHMASLLSRCRPDCPIFAFTTTTSVRRRLNLQWGLIPFRLSFADDMESNLN 459
Query: 442 ----LIKGLGLVESDDIVL 456
L+K G+++S D+V+
Sbjct: 460 KTFSLLKARGMIKSGDLVI 478
>sp|P78031|KPYK_MYCPN PYRUVATE KINASE (PK) >gi|2146579|pir||S73859 pyruvate kinase (EC
2.7.1.40) pyk - Mycoplasma pneumoniae (strain ATCC
29342) >gi|1674229|gb|AAB96181.1| (AE000052) pyruvate
kinase [Mycoplasma pneumoniae]
Length = 508
Score = 212 bits (533), Expect = 1e-53
Identities = 136/361 (37%), Positives = 202/361 (55%), Gaps = 27/361 (7%)
Query: 10 KTKIVATIGPATSSRNM--------------------IKKLIENGVSVVRLNFSHGSFEE 49
+TKI+AT GPA + + I+ +I+NGV+V+RLNFSHG+ EE
Sbjct: 7 RTKIIATCGPALTKKLWTLAMLDDPAYAAMKAEAYANIENIIKNGVTVIRLNFSHGNHEE 66
Query: 50 HAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKG-GYVELKRGEKVVLTTRDVVGDE 108
A I+ VRD+++KL+ V+I+ D G +IRV E G LK E V+ TT V
Sbjct: 67 QAVRIKIVRDVAKKLNLPVSIMLDTNGPEIRVFETAPEGLKILKDSEVVINTTTKEVAKN 126
Query: 109 TTIPVEYK----DFPRLVSKGDVIYLSDGYIVLRVEEV--RGQDVEAVVVSGGKLFSRKG 162
V + V G I + DG + L V+ + + V V + +F++K
Sbjct: 127 NQFSVSDASGTYNMVNDVKVGQKILVDDGKLSLVVKRIDTKNNQVICVAQNDHTIFTKKR 186
Query: 163 INIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFV 222
+N+P A + ++ +D+ I F + +D I SFV + ++ +++ +L +A+ V +
Sbjct: 187 LNLPNADYSIPFLSAKDLRDIDFGLTHQIDYIAASFVNTTENIKQLRDYLASKNAKHVKL 246
Query: 223 ISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITA 282
I+KIE A+ N D I+KASDGIM+ARGDLG+E+P ++P Q+ +I+ K VITA
Sbjct: 247 IAKIESNHALNNIDGIIKASDGIMVARGDLGLEIPYYKVPYWQRYMIKACRFFNKRVITA 306
Query: 283 TQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEE 342
TQML S+ PTRAEVTDV A+ G DA MLS ETA G FP++AV +M I K +E
Sbjct: 307 TQMLDSLEKNIQPTRAEVTDVYFAVDRGNDATMLSGETANGAFPLNAVYVMKMIDKQSET 366
Query: 343 Y 343
+
Sbjct: 367 F 367
>dbj|BAA15445.1| (D90810) Pyruvate kinase (EC 2.7.1.40) I [Escherichia coli]
Length = 264
Score = 210 bits (528), Expect = 4e-53
Identities = 106/262 (40%), Positives = 165/262 (62%), Gaps = 2/262 (0%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
KTKIV TIGP T S M+ K+++ G++V+RLNFSHG + EH + I+ +R++ K + A
Sbjct: 3 KTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAA 62
Query: 70 ILADLPGLKIRVGEIKGGY-VELKRGEKVVLTT-RDVVGDETTIPVEYKDFPRLVSKGDV 127
IL D G +IR +++GG V LK G+ TT + V+G+ + V Y+ F +S G+
Sbjct: 63 ILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNT 122
Query: 128 IYLSDGYIVLRVEEVRGQDVEAVVVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIKFAI 187
+ + DG I + V + G V V++ G L KG+N+P + + A+ +D + + F
Sbjct: 123 VLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGC 182
Query: 188 EQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVFVISKIERPDAVRNFDEILKASDGIMI 247
EQGVD + SF+ DV++++ L+ + E++ +ISKIE + + NFDEIL+ASDGIM+
Sbjct: 183 EQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGIMV 242
Query: 248 ARGDLGVEMPIERLPILQKELI 269
ARGDLGVE+P+E + QK +I
Sbjct: 243 ARGDLGVEIPVEEVIFAQKMMI 264
>pir||T47556 pyruvate kinase-like protein - Arabidopsis thaliana
>gi|7529723|emb|CAB86903.1| (AL132969) pyruvate
kinase-like protein [Arabidopsis thaliana]
Length = 514
Score = 199 bits (501), Expect = 5e-50
Identities = 138/476 (28%), Positives = 244/476 (50%), Gaps = 36/476 (7%)
Query: 11 TKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAI 70
TKIV T+GP + S + ++ G+SV R +FS G + H + ++ ++ + + A+
Sbjct: 17 TKIVGTLGPKSRSVEALSGCLKAGMSVARFDFSWGDADYHQETLDNLKVAVRSTKKLCAV 76
Query: 71 LADLPGLKIRVGEIKGGYVELKRGEKVVLT-TRDVVGDETTIPVEYKDFPRLVSKGDVI- 128
+ D G +++V + LK V LT +D +P+ + + V KGD I
Sbjct: 77 MLDTVGPELQVINKSEKAITLKADGLVTLTPNQDQEASSEVLPINFNGLAKAVKKGDTIF 136
Query: 129 ---YLSDGY----IVLRVEEVRGQDVEAV----VVSGGKLFSRKGINIPKAYLPVEAVTP 177
YL G + L V+EV+G DV + G LF+ ++ + ++ + +T
Sbjct: 137 VGQYLFTGSETTSVWLEVDEVKGDDVICLSRNAATLAGSLFT---LHSSQVHIDLPTLTE 193
Query: 178 RDMEIIK-FAIEQGVDAIGLSFVGSVYDVLKVKSFLEK-NDAEDVFVISKIERPDAVRNF 235
+D E+I + ++ +D + LS+ DV + + L+K D + +KIE + + +F
Sbjct: 194 KDKEVISTWGVQNKIDFLSLSYCRHAEDVRQTREMLKKLGDLSQTQIFAKIENVEGLTHF 253
Query: 236 DEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVP 295
DEIL+ +DGI+++RG+LG+++P E++ + QK + K N GKP + T+++ SMT P
Sbjct: 254 DEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-LTRVVDSMTDNLRP 312
Query: 296 TRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI-AKVTEEYRESFGMSRLRE 354
TRAE TDVANA+LDG+DA++L ET G +P++ + + +I A+ + + + + +
Sbjct: 313 TRAEATDVANAVLDGSDAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVK 372
Query: 355 LVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNER 414
V G T E+IA S + A + I+ T +GR ARLI++++P +
Sbjct: 373 YV--GEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVISVVIPRV 430
Query: 415 VCNNLMFSYGVYAFCLEEGFDERDIIRLIKGLGLVESDDIVLMTEGKPIEKTMGTN 470
N L +S+ F+ R + +++GL + +D P E T TN
Sbjct: 431 KTNQLKWSF-------SGAFEARQSL-IVRGLFPMLAD------PRHPAESTSATN 472
>gb|AAD24640.1|AC006919_20 (AC006919) putative pyruvate kinase [Arabidopsis thaliana]
Length = 464
Score = 178 bits (446), Expect = 2e-43
Identities = 128/448 (28%), Positives = 223/448 (49%), Gaps = 38/448 (8%)
Query: 35 VSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVELKRG 94
+SV R +FS + H + +E ++ + + A++ D G +++V + LK
Sbjct: 1 MSVARFDFSWCDADYHQETLENLKIAVKSTKKLCAVMLDTVGPELQVINKTEKAISLKAD 60
Query: 95 EKVVLT-TRDVVGDETTIPVEYKDFPRLVSKGDVI----YLSDGYIVLRVEEVRGQDVEA 149
V LT ++D +P+ + + V KGD I YL G VEEV+G DV
Sbjct: 61 GLVTLTPSQDQEASSEVLPINFDGLAKAVKKGDTIFVGQYLFTGSETTSVEEVKGDDVIC 120
Query: 150 V----VVSGGKLFSRKGINIPKAYLPVEAVTPRDMEIIK-FAIEQGVDAIGLSFVGSVYD 204
+ GG LF+ +++ + ++ + +T +D E+I + ++ +D + LS+ D
Sbjct: 121 ISRNAATLGGPLFT---LHVSQVHIDMPTLTEKDKEVISTWGVQNKIDFLSLSYCRHAED 177
Query: 205 VLKVKSFLEK-NDAEDVFVISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPI 263
V + + L D + +KIE + + +FDEIL+ +DGI+++RG+LG+++P E
Sbjct: 178 VRQARELLNSCGDLSQTQIFAKIENEEGLTHFDEILQEADGIILSRGNLGIDLPPE---- 233
Query: 264 LQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIG 323
K + K N GKP + T+++ SMT PTRAE TDVANA+LDG+DA++L ET G
Sbjct: 234 --KAALYKCNMAGKPAVL-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRG 290
Query: 324 KFPIDAVKMMAKIAKVTEE-YRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIK 382
+P++ + + +I E+ + + + + V G T E+IA S + A +
Sbjct: 291 LYPVETISTVGRICCEAEKVFNQDLFFKKTVKYV--GEPMTHLESIASSAVRAAIKVKAS 348
Query: 383 YILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRL 442
I+ T +GR ARLI++++P + N L +S+ F+ R + +
Sbjct: 349 VIICFTSSGRAARLIAKYRPTMPVLSVVIPRLTTNQLKWSF-------SGAFEARQSL-I 400
Query: 443 IKGLGLVESDDIVLMTEGKPIEKTMGTN 470
++GL + +D P E T TN
Sbjct: 401 VRGLFPMLAD------PRHPAESTSATN 422
>pir||B82923 pyruvate kinase UU186 [imported] - Ureaplasma urealyticum
>gi|6899150|gb|AAF30593.1|AE002118_3 (AE002118) pyruvate
kinase [Ureaplasma urealyticum]
Length = 474
Score = 176 bits (441), Expect = 6e-43
Identities = 118/360 (32%), Positives = 198/360 (54%), Gaps = 31/360 (8%)
Query: 10 KTKIVATIGPATSS-----------RNM---------IKKLIENGVSVVRLNFSHGSFEE 49
KT+I+AT+GPAT+ N+ IK LI +GV++ R+N SHG +
Sbjct: 4 KTRIIATVGPATTKLFSNWLEFNDLNNINDAQQVCINIKDLILSGVNIFRMNLSHGDQKI 63
Query: 50 HAKVIEKVRDISQKLDRRVAILADLPGLKIRVGEIKGGYVELKRGEKVVLTTRDVVGDET 109
H + ++ I+ +L +V IL D G +IRV E+ +K E ++ V+G
Sbjct: 64 HLFRTQLIKKIADELKIKVEILFDTKGPEIRVCEMSDNNFIIKNSEVIIHCKEKVLGSFN 123
Query: 110 TIPV-EYKDFPRLVSKGDV---IYLSDGYIVLRVEEVRGQDVEAVVVSGGK----LFSRK 161
V + ++S + I + DG ++L V+++ ++ ++ + K L + K
Sbjct: 124 EFSVTDATGQYNMISDVKINHRILIDDGKLILIVKKI--DFLKNIIYTTAKNSYSLKTNK 181
Query: 162 GINIPKAYLPVEAVTPRDMEIIKFAIEQGVDAIGLSFVGSVYDVLKVKSFLEKNDAEDVF 221
+N+P A + ++ +D++ I A++ + + LSF+ ++ + +VK L+K+
Sbjct: 182 RLNLPDANYSLPFLSKKDIDDINLAVKLKIPYLALSFISNIKQINEVKQLLKKSSFIPK- 240
Query: 222 VISKIERPDAVRNFDEILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVIT 281
+I+KIE +A+ N +EI+K +DGIM+ARGDLG+E+P ++PI Q +++ + K I
Sbjct: 241 LIAKIETQEAIDNLEEIIKNTDGIMVARGDLGLEVPFYKIPIYQNKIVELCHKYNKYCII 300
Query: 282 ATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE 341
ATQML S+ +PTRAEVTDV A+ +A MLS ETA G PI+AV++M I TE
Sbjct: 301 ATQMLDSLERNIIPTRAEVTDVYYAVKQKVNATMLSGETAAGIDPINAVQVMKSIILETE 360
>sp|O30853|KPY1_PHOLE PYRUVATE KINASE I (PK-1) >gi|7434445|pir||PC4418 pyruvate kinase
(EC 2.7.1.40) I - Photobacterium leiognathi (fragment)
>gi|2407666|gb|AAC45776.1| (AF019143) pyruvate kinase I
[Photobacterium leiognathi]
Length = 235
Score = 153 bits (384), Expect = 3e-36
Identities = 100/240 (41%), Positives = 132/240 (54%), Gaps = 12/240 (5%)
Query: 241 ASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPTRAEV 300
ASDGIM+ARGDLGVE+P+E + QK +I K N K VITATQML SM PTRAE
Sbjct: 1 ASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEA 60
Query: 301 TDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTEEYRESFGMSRLRELVEDGT 360
DVANAI+DGTDAVMLS E+A GK+PI+AV +MA+I T++ + SRL D
Sbjct: 61 GDVANAIMDGTDAVMLSGESAKGKYPIEAVTIMAQICARTDDVVKPELGSRL-----DSP 115
Query: 361 RGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARLISRFKPKQWIFGFSTNERVCNNLM 420
R I EA+ + +D LN I+ T G++AR + ++ P I +TN + L
Sbjct: 116 RLRITEAVCKGAVDTAEKLNAPLIIVATEAGKSARSVRKYFPTARILAVTTNTKTAAQLC 175
Query: 421 FSYGVYAFCLEEGFDERDII-----RLIKGLGLVESDDIVLMTEGKPIEK-TMGTNSIKI 474
S GV + + + D L GL DIV+M G + T T S+ +
Sbjct: 176 LSKGVTPVVV-DSIESTDAFYLRGKELALETGLGAKGDIVVMVSGALVASGTTNTASVHV 234
>gb|AAF19604.1|AF150875_1 (AF150875) pyruvate kinase [Giardia intestinalis]
Length = 517
Score = 146 bits (364), Expect = 6e-34
Identities = 109/396 (27%), Positives = 195/396 (48%), Gaps = 21/396 (5%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+ K++A++GP+ ++ I ++I +G R+ + S EE+ ++ VR + + ++
Sbjct: 39 RAKVIASLGPSCNTEGSIAQMIRHGADAFRIVMAKASNEENIRLYNLVRKCAADQKKHIS 98
Query: 70 ILADLPGLKIRVGEIKG--GYVELKRGEKVVLTTRDVVGDET--TIPVEYKDFPRLVSKG 125
I+A L G K RV + + L+ G ++ + + + T+ V + ++ G
Sbjct: 99 IIASLQGPKFRVTRFRNTTNSITLQEGSELNIMFNKAMECDAPNTVFVNESEIFTVIEVG 158
Query: 126 DVIYLSDGYIVLRVEEVRGQ--DVEAVVVSGG--KLFSRKGINIPKAYLPVEAVTPRDME 181
D + +G ++ +V V +V+AVV + G KL+ + IP + +T + E
Sbjct: 159 DEVVFKNGPLIAKVTSVSPDKTNVKAVVTTRGSTKLYGGSSLRIPSKLSSIAPLTSLEYE 218
Query: 182 IIKFAIEQ-GVDAIGLSFVGSVYDVLKVKS---FLEKNDAE-DVFVISKIERPDAVRNFD 236
+ E+ VD I S + + D+ +++ FL K + +++K+E P AV N
Sbjct: 219 HLHLLAEKMPVDWICYSHINTESDIKHIENYTDFLSKKYPDFRPMLMTKVETPLAVLNLK 278
Query: 237 EILKASDGIMIARGDLGVEMPIERLPILQKELIRKANTEGKPVITATQMLVSMTAEKVPT 296
+I+ DGIMIARG LG EM LP +QK +I+ A GK AT + SM+ +PT
Sbjct: 279 QIVTHVDGIMIARGALGDEMDFSYLPSIQKSIIQIARDSGKMCYIATNVCESMSENVIPT 338
Query: 297 RAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKIAKVTE------EYRES--FG 348
RAEV+DV N + DG D +L ET+ G + VK + +I E YR F
Sbjct: 339 RAEVSDVTNCLGDGCDGFVLCAETSTGHHSVATVKYLVEIIVAVENDPLDVSYRSKVLFS 398
Query: 349 MSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYI 384
+ ++ ++ ++ + ++I+ S I L+ K I
Sbjct: 399 GTTRKQPLKTDSQHRLPDSISVSAISLASILDAKCI 434
>dbj|BAA16043.1| (D90853) Pyruvate kinase (EC 2.7.1.40) I [Escherichia coli]
Length = 198
Score = 118 bits (293), Expect = 1e-25
Identities = 75/184 (40%), Positives = 103/184 (55%), Gaps = 9/184 (4%)
Query: 277 KPVITATQMLVSMTAEKVPTRAEVTDVANAILDGTDAVMLSEETAIGKFPIDAVKMMAKI 336
K VITATQML SM PTRAE DVANAILDGTDAVMLS E+A GK+P++AV +MA I
Sbjct: 8 KVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATI 67
Query: 337 AKVTEEYRESFGMSRLRELVEDGTRGTIKEAIARSIIDALCTLNIKYILTPTRTGRTARL 396
+ T+ M+ E D + I EA+ R ++ L+ I+ T+ G++AR
Sbjct: 68 CERTDRV-----MNSRLEFNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARA 122
Query: 397 ISRFKPKQWIFGFSTNERVCNNLMFSYGVYAFCLEEGFDERDIIRLIKGL----GLVESD 452
+ ++ P I +TNE+ + L+ S GV ++E D RL K L GL
Sbjct: 123 VRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKG 182
Query: 453 DIVL 456
D+V+
Sbjct: 183 DVVV 186
>gb|AAB69999.1| (AF012877) pyruvate kinase [Spiroplasma citri]
Length = 157
Score = 87.4 bits (213), Expect = 3e-16
Identities = 50/144 (34%), Positives = 81/144 (55%), Gaps = 6/144 (4%)
Query: 10 KTKIVATIGPATSSRNMIKKLIENGVSVVRLNFSHGSFEEHAKVIEKVRDISQKLDRRVA 69
+TKI+ TIGP+T S I++L + G++ +RLNFSHG E I R++S K+ + ++
Sbjct: 12 RTKIITTIGPSTHSPGAIEELFKTGMTTIRLNFSHGDHAEQGARIVWAREVSAKIGKPIS 71
Query: 70 ILADLPGLKIRVGEIKGGYVELKRGEKVVLTT-----RDVVGDETTIPVEYKDFPRLVSK 124
+L D G +IR G +KGG E+ G V + + ++ G T I V Y D + +
Sbjct: 72 VLLDTKGPEIRAGIMKGGKQEIVAGATVTIYSLPTEYQNREGTGTEITVSY-DMSQDLKV 130
Query: 125 GDVIYLSDGYIVLRVEEVRGQDVE 148
GDV+ + DG + L V ++ +E
Sbjct: 131 GDVVLVDDGKLQLNVTGIKPGIIE 154
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.320 0.139 0.380
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 159376800
Number of Sequences: 2977
Number of extensions: 6617387
Number of successful extensions: 21961
Number of sequences better than 1.0e-10: 165
Number of HSP's better than 0.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 21281
Number of HSP's gapped (non-prelim): 174
length of query: 478
length of database: 189,106,746
effective HSP length: 60
effective length of query: 418
effective length of database: 153,197,526
effective search space: 64036565868
effective search space used: 64036565868
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 167 (69.5 bits)