BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1498 (pyrB) DE:aspartate carbamoyltransferase, catalytic
subunit (pyrB)
(308 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|P77918|PYRB_PYRAB ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 608 e-173
sp|O58451|PYRB_PYRHO ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 573 e-163
gi|11497726 aspartate carbamoyltransferase, catalytic subunit (p... 366 e-100
sp|Q58976|PYRB_METJA ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 349 3e-95
sp|O27464|PYRB_METTH ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 344 6e-94
gb|AAG20942.1| (AE005160) aspartate carbamoyltransferase catalyt... 336 2e-91
emb|CAC11715.1| (AL445064) probable aspartate carbamoyltransfera... 331 6e-90
pir||A81238 aspartate carbamoyltransferase (EC 2.1.3.2) catalyti... 321 6e-87
pdb|1RAA|A Chain A, Aspartate Transcarbamoylase (E.C.2.1.3.2) (A... 310 9e-84
gb|AAA24476.1| (K01472) aspartate transcarbamoylase catalytic ch... 310 9e-84
sp|P00479|PYRB_ECOLI ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CH... 310 9e-84
pdb|1D09|A Chain A, Aspartate Transcarbamoylase Complexed With N... 310 1e-83
sp|P96174|PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CH... 310 2e-83
pdb|8ATC|A Chain A, Aspartate Carbamoyltransferase (Aspartate Tr... 309 3e-83
pdb|9ATC|A Chain A, Atcase Y165f Mutant 309 3e-83
pir||H82066 aspartate carbamoyltransferase, catalytic chain VC25... 309 4e-83
sp|P20054|PYR1_DICDI PROTEIN PYR1-3 [INCLUDES: GLUTAMINE-DEPENDE... 308 5e-83
emb|CAA32782.1| (X14634) PYR1-3B multifunctional enzyme (1014 AA... 308 5e-83
pir||QZDOP3 pyrimidine synthesis protein PYR1-3 - slime mold (D... 308 5e-83
pdb|1EZZ|A Chain A, Crystal Structure Of E. Coli Aspartate Trans... 307 8e-83
gb|AAA97142.1| (U14003) aspartate carbomoyltransferase catalytic... 307 1e-82
pdb|1ACM|A Chain A, Aspartate Carbamoyltransferase (Aspartate Tr... 307 1e-82
gb|AAA24474.1| (J01670) aspartate transcarbamoylase catalytic ch... 305 3e-82
sp|P08420|PYRB_SALTY ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CH... 302 3e-81
sp|Q91437|PYR1_SQUAC CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT ... 300 1e-80
pir||C72547 probable aspartate carbamoyltransferase catalytic ch... 300 1e-80
gb|AAA68280.1| (M27174) carbamyl phosphate synthetase [Saccharom... 295 5e-79
emb|CAA60825.1| (X87371) carbamyl phosphate synthetase [Saccharo... 294 6e-79
gi|6322331 carbamoyl-phophate synthetase, aspartate transcarbamy... 294 6e-79
gb|AAF01338.1|AF190426_2 (AF190426) aspartate transcarbamylase c... 293 1e-78
pir||OWEBAC aspartate carbamoyltransferase (EC 2.1.3.2) catalyti... 293 2e-78
sp|Q09794|PYR1_SCHPO URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT... 289 3e-77
sp|P08955|PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT ... 289 3e-77
gb|AAA37064.1| (M23652) CAD protein [Mesocricetus auratus] 289 3e-77
sp|Q43086|PYB1_PEA ASPARTATE CARBAMOYLTRANSFERASE 1 PRECURSOR (A... 287 1e-76
pir||A36240 pyrimidine synthesis protein CAD - human (fragment) ... 287 1e-76
gi|4757896 carbamoyl-phosphate synthetase 2, aspartate transcarb... 287 1e-76
sp|Q55338|PYRB_SULAC ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 286 2e-76
sp|P19910|PYRB_SERMA ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CH... 284 7e-76
pir||S65074 pyrimidine synthesis protein URA1 - fission yeast (... 283 2e-75
pdb|2ATC|A Chain A, Aspartate Carbamoyltransferase (Aspartate Tr... 282 3e-75
sp|P57450|PYRB_BUCAI ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CH... 281 6e-75
dbj|BAB02813.1| (AB024036) aspartate carbamoyltransferase [Arabi... 279 4e-74
sp|Q43064|PYB3_PEA ASPARTATE CARBAMOYLTRANSFERASE 3 PRECURSOR (A... 278 5e-74
gb|AAA35198.1| (J04711) carbamylase phosphate synthetase-asparta... 277 9e-74
sp|Q43087|PYB2_PEA ASPARTATE CARBAMOYLTRANSFERASE 2 PRECURSOR (A... 277 9e-74
sp|P49077|PYRB_ARATH ASPARTATE CARBAMOYLTRANSFERASE PRECURSOR (A... 277 1e-73
gb|AAK40925.1| Aspartate carbamoyltransferase catalytic chain (A... 275 4e-73
sp|Q9UX08|PYRB_SULSO ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 275 4e-73
dbj|BAB03303.1| (AB037416) aspartate carbamoyl transferase [Oryz... 274 1e-72
gb|AAF48639.2| (AE003503) CG18572 gene product [Drosophila melan... 272 5e-72
pir||S35212 aspartate carbamoyltransferase (EC 2.1.3.2) - tomato... 266 3e-70
pir||T20371 hypothetical protein D2085.1 - Caenorhabditis elegan... 265 5e-70
pir||S42709 aspartate carbamoyltransferase (EC 2.1.3.2) - tomato... 262 3e-69
gb|AAD09129.1| (AF112473) PyrABCN [Aspergillus nidulans] 256 2e-67
gi|9631738 contains carbamyltransferase motif; similar to Arabid... 245 4e-64
dbj|BAA22792.1| (AB007852) aspartate carbamoyltransferase [Trypa... 238 5e-62
pir||T30522 aspartate carbamoyltransferase (EC 2.1.3.2) - Trypan... 238 8e-62
dbj|BAA94298.1| (AB029444) Aspartate carbamoyltransferase [Leish... 238 8e-62
gb|AAG21801.1|AF192346_1 (AF192346) aspartate transcarbamoylase ... 234 9e-61
pir||S47625 aspartate carbamoyltransferase (EC 2.1.3.2) - wheat ... 230 1e-59
gb|AAB86625.1| (AF031144) aspartate transcarbamoylase [Plasmodiu... 228 7e-59
sp|P05990|PYR1_DROME CAD PROTEIN (RUDIMENTARY PROTEIN) [INCLUDES... 202 5e-51
gb|AAA37009.1| (M33702) dihydroorotase synthetase complex (EC 3.... 192 3e-48
pir||D75435 aspartate carbamoyltransferase - Deinococcus radiodu... 173 2e-42
emb|CAB93367.1| (AL357523) aspartate carbamoyltransferase [Strep... 164 9e-40
sp|P96079|PYRB_THEAQ ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 164 2e-39
dbj|BAB06258.1| (AP001515) aspartate carbamoyltransferase [Bacil... 163 2e-39
sp|P05654|PYRB_BACSU ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 161 8e-39
pdb|2AT2|A Chain A, Aspartate Transcarbamoylase (E.C.2.1.3.2) (A... 161 8e-39
sp|P41008|PYRB_BACCL ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 159 4e-38
pir||I40166 aspartate carbamoyltransferase (EC 2.1.3.2) - Bacill... 159 4e-38
pir||C33917 pyrimidine synthesis protein CAD - Chinese hamster ... 155 4e-37
sp|P77883|PYRB_LACPL ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 155 8e-37
sp|Q59711|PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 150 3e-35
pir||H83595 aspartate carbamoyltransferase PA0402 [imported] - P... 150 3e-35
sp|Q59653|PYRB_PSEAE ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 149 3e-35
pir||A48948 aspartate carbamoyltransferase (EC 2.1.3.2) - Trepon... 147 2e-34
sp|Q04595|PYRB_TREDE PYRBI PROTEIN [INCLUDES: ASPARTATE CARBAMOY... 147 2e-34
sp|P71808|PYRB_MYCTU ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 146 3e-34
sp|Q60252|PYRB_LACLE ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 145 5e-34
gb|AAG15558.1| (AY007523) aspartate carbamoyl transferase PyrB [... 145 8e-34
sp|P74163|PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 144 1e-33
pir||E81313 aspartate carbamoyltransferase (EC 2.1.3.2) Cj1098 [... 144 1e-33
gb|AAF72727.1| (AF264709) aspartate transcarbamoylase [Enterococ... 144 1e-33
sp|P18186|OTCA_BACSU ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (O... 140 2e-32
gb|AAA37061.1| (M11242) CAD protein [Mesocricetus auratus] 138 8e-32
sp|O66726|PYRB_AQUAE ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 136 3e-31
sp|Q9ZM81|PYRB_HELPJ ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 134 9e-31
gb|AAB99909.1| (AF018428) aspartate carbamoyltransferase; ACTase... 134 2e-30
sp|O25716|PYRB_HELPY ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE T... 133 3e-30
pir||T45077 ornithine carbamoyltransferase [imported] - Pyrococc... 131 1e-29
emb|CAA28502.1| (X04813) CAD protein (AA 1 - 2236) [Drosophila m... 131 1e-29
emb|CAA71345.1| (Y10300) aspartate carbamoyltransferase with fus... 130 2e-29
sp|P96111|PYRB_THEMA PYRBI PROTEIN [INCLUDES: ASPARTATE CARBAMOY... 130 2e-29
sp|O93656|OTC_PYRAB ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|... 129 3e-29
sp|O58457|OTC_PYRHO ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|... 129 4e-29
gi|11498854 ornithine carbamoyltransferase (argF) [Archaeoglobus... 129 5e-29
pir||H82583 aspartate carbamoyltransferase XF2226 [imported] - X... 129 5e-29
pdb|1A1S| Ornithine Carbamoyltransferase From Pyrococcus Furiosus 127 1e-28
sp|Q51742|OTC_PYRFU ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|... 127 2e-28
sp|P96108|OTCA_THEMA ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (O... 126 3e-28
gb|AAD09004.1| (AF083209) ornithine carbamoyltransferase [Pyroco... 126 3e-28
dbj|BAB06613.1| (AP001517) ornithine carbamoyltransferase [Bacil... 126 3e-28
sp|Q55497|OTCA_SYNY3 ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (O... 124 1e-27
emb|CAB89871.1| (AJ132624) aspartate transcarbamoylase [Lactococ... 123 2e-27
gb|AAC36050.1| (AF030524) ornithine carbamoyltransferase; OCT [N... 120 3e-26
sp|Q58291|OTC_METJA ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|... 116 2e-25
sp|P31326|OTC_RANCA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OT... 115 5e-25
gb|AAF61409.1|AF134845_1 (AF134845) ornithine transcarbamylase [... 115 7e-25
pir||E70447 ornithine carbamoyltransferase - Aquifex aeolicus >g... 114 1e-24
pir||JE0309 ornithine carbamoyltransferase (EC 2.1.3.3) - chicke... 114 1e-24
gb|AAF61410.1|AF134846_1 (AF134846) ornithine transcarbamylase [... 114 2e-24
sp|O86132|OTCC_BACLI ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (... 113 2e-24
gb|AAF61408.1|AF134844_1 (AF134844) ornithine transcarbamylase [... 113 3e-24
sp|O19072|OTC_PIG ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCA... 112 5e-24
gi|6679184 ornithine transcarbamylase [Mus musculus] >gi|129277|... 110 2e-23
gi|6981312 ornithine carbamoyltransferase [Rattus norvegicus] >g... 110 2e-23
pir||B72502 probable ornithine carbamoyltransferase APE1992 - Ae... 110 2e-23
prf||1403355A Orn transcarbamylase [Homo sapiens] 108 7e-23
gb|AAF61407.1|AF134843_1 (AF134843) ornithine transcarbamylase [... 108 7e-23
pdb|1C9Y|A Chain A, Human Ornithine Transcarbamylase: Crystallog... 108 9e-23
emb|CAA26007.1| (X01976) OTCase precursor [Rattus norvegicus] 108 1e-22
gi|9257234 ornithine carbamoyltransferase precursor; Ornithine t... 108 1e-22
sp|P00480|OTC_HUMAN ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OT... 107 2e-22
emb|CAA30121.1| (X07092) ornithine transcarbamylase [Mus musculus] 107 2e-22
gb|AAF61405.1|AF134841_1 (AF134841) ornithine transcarbamylase [... 107 2e-22
gb|AAF17704.1|AF033561_1 (AF033561) ornithine carbamoyltransfera... 107 2e-22
pir||T46742 ornithine carbamoyltransferase (EC 2.1.3.3) [validat... 105 8e-22
gb|AAA41772.1| (K00001) preornithine carbamoyl transferase [Ratt... 104 1e-21
pir||A70205 ornithine carbamoyltransferase, catabolic (arcB) hom... 104 1e-21
gb|AAC78720.1| (U43091) ornithine carbamoyltransferase [Bacillus... 103 3e-21
sp|Q43814|OTC_PEA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCA... 102 4e-21
gb|AAB93999.1| (AF008219) ArcB [Borrelia afzelii] 102 4e-21
sp|O27495|OTC_METTH ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|... 101 1e-20
gb|AAG13075.1|AC023754_13 (AC023754) Ornithine carbamoyltransfer... 101 1e-20
emb|CAA27513.1| (X03879) rudimentary protein fragment [Drosophil... 100 3e-20
gb|AAF61406.1|AF134842_1 (AF134842) ornithine transcarbamylase [... 99 4e-20
gb|AAF17705.1|AF033562_1 (AF033562) ornithine carbamoyltransfera... 96 4e-19
sp|O50039|OTC_ARATH ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OT... 96 5e-19
emb|CAB75986.1| (AJ272085) ornithine carbamoyltransferase [Staph... 90 3e-17
gb|AAD32177.1|AF125563_2 (AF125563) ornithine carbomyltransferas... 90 4e-17
pir||E81066 ornithine carbamoyltransferase, catabolic NMB1573 [i... 90 4e-17
pir||B81801 ornithine carbamoyltransferase (EC 2.1.3.3) NMA1762 ... 90 4e-17
emb|CAB93580.1| (AJ250129) ornithine transcarbamylase [Lactococc... 87 3e-16
sp|O08322|OTCA_LACPL ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (O... 86 4e-16
sp|P21302|OTCC_NEIGO ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (... 85 1e-15
gb|AAF86986.1|AF282249_5 (AF282249) ArcB [Lactococcus lactis sub... 85 1e-15
sp|P14995|OTC_PACTA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OT... 84 2e-15
pir||F82066 ornithine carbamoyltransferase VC2508 [imported] - V... 83 4e-15
sp|Q46169|OTCC_CLOPE ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (... 82 8e-15
pir||F75562 ornithine carbamoyltransferase - Deinococcus radiodu... 82 1e-14
sp|P23752|OTCC_PSESH ORNITHINE CARBAMOYLTRANSFERASE, PHASEOLOTOX... 81 1e-14
gb|AAK41159.1| Ornithine carbamoyltransferase (argF) [Sulfolobus... 81 2e-14
sp|O31018|OTCC_RHIET ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (... 81 2e-14
gb|AAD01405.1| (AF007428) ornithine carbamoyltransferase homolog... 79 6e-14
prf||1707278A Orn carbamoyltransferase [Pseudomonas syringae pv.... 78 1e-13
emb|CAA39136.1| (X55520) phaseolotoxin-insensitive ornithine car... 78 1e-13
sp|P44770|OTCC_HAEIN ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (... 77 3e-13
emb|CAA66276.1| (X97684) ornithine carbamoyl transferase [Clostr... 75 1e-12
pir||S24720 ornithine carbamoyltransferase (EC 2.1.3.3) - Neisse... 71 2e-11
>sp|P77918|PYRB_PYRAB ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433599|pir||C75042 aspartate
carbamoyltransferase, catalytic chain (pyrb) PAB1498 -
Pyrococcus abyssi (strain Orsay)
>gi|1572497|gb|AAB62984.1| (U61765) aspartate
transcarbamylase catalytic chain [Pyrococcus abyssi]
>gi|5458745|emb|CAB50232.1| (AJ248287) aspartate
carbamoyltransferase, catalytic subunit (pyrB)
[Pyrococcus abyssi]
Length = 308
Score = 608 bits (1551), Expect = e-173
Identities = 308/308 (100%), Positives = 308/308 (100%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL
Sbjct: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
Query: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV
Sbjct: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY 180
AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY
Sbjct: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY 180
Query: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE 240
DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE
Sbjct: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE 240
Query: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL
Sbjct: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
Query: 301 LALVLGVI 308
LALVLGVI
Sbjct: 301 LALVLGVI 308
>sp|O58451|PYRB_PYRHO ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433581|pir||A71119 probable aspartate
carbamoyltransferase catalytic chain - Pyrococcus
horikoshii >gi|3257128|dbj|BAA29811.1| (AP000003) 308aa
long hypothetical aspartate carbamoyltransferase
catalytic chain [Pyrococcus horikoshii]
Length = 308
Score = 573 bits (1461), Expect = e-163
Identities = 285/308 (92%), Positives = 299/308 (96%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
M+WKGRDVISIRDFSKEDIE VL+TAERLE+E+KEKGQLEYAKGKILATLFFEPSTRTRL
Sbjct: 1 MEWKGRDVISIRDFSKEDIEVVLSTAERLEKEMKEKGQLEYAKGKILATLFFEPSTRTRL 60
Query: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
SFESAMHRLGG+VIGFAEASTSSVKKGESLRDTIKTVEQY DVIVIRHPKEGAARLAAEV
Sbjct: 61 SFESAMHRLGGSVIGFAEASTSSVKKGESLRDTIKTVEQYSDVIVIRHPKEGAARLAAEV 120
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY 180
A++PVINAGDGSNQHPTQTLLDLYTIKKEFG IDGLKIGLLGDLKYGRTVHSLAEAL FY
Sbjct: 121 ADIPVINAGDGSNQHPTQTLLDLYTIKKEFGTIDGLKIGLLGDLKYGRTVHSLAEALAFY 180
Query: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE 240
DVELYLISPELLRMP+HIVEELRE+GMK+VETT LE+VIG+LDVLYVTRIQKERFPDEQE
Sbjct: 181 DVELYLISPELLRMPKHIVEELRERGMKIVETTKLEEVIGELDVLYVTRIQKERFPDEQE 240
Query: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
YLKVKGSYQVNLK+LE KD LRIMHPLPRVDEIHPEVD TKHAIYF+QVFNGVPVRMAL
Sbjct: 241 YLKVKGSYQVNLKILENVKDSLRIMHPLPRVDEIHPEVDKTKHAIYFKQVFNGVPVRMAL 300
Query: 301 LALVLGVI 308
LALVLGVI
Sbjct: 301 LALVLGVI 308
>gi|11497726 aspartate carbamoyltransferase, catalytic subunit (pyrB)
[Archaeoglobus fulgidus]
>gi|3914510|sp|O30130|PYRB_ARCFU ASPARTATE
CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433583|pir||B69263 aspartate
carbamoyltransferase, catalytic subunit (pyrB) homolog -
Archaeoglobus fulgidus >gi|2650542|gb|AAB91125.1|
(AE001099) aspartate carbamoyltransferase, catalytic
subunit (pyrB) [Archaeoglobus fulgidus]
Length = 299
Score = 366 bits (930), Expect = e-100
Identities = 181/300 (60%), Positives = 224/300 (74%), Gaps = 4/300 (1%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
R +ISI D +EDI +L AE E + + +L +GKIL LFFEPSTRTR+SFE+A
Sbjct: 3 RHLISIGDLDREDINYILKKAEEFEDVARGEKKLRILEGKILGNLFFEPSTRTRMSFETA 62
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
M RLGG VI SS+ KGE+L DTI+ V YCD IVIRHP EGAAR AAE + VPV
Sbjct: 63 MKRLGGDVINMTAQEASSIAKGETLADTIRVVSGYCDAIVIRHPLEGAARFAAENSSVPV 122
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELY 185
INAGDG+ QHPTQTLLDLYTIKKE GR+DG+ I L+GDLKY RT+HSL +AL +D+ +Y
Sbjct: 123 INAGDGAGQHPTQTLLDLYTIKKECGRLDGITIALMGDLKYSRTIHSLIKALALFDMRIY 182
Query: 186 LISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVK 245
LISPE L +P I+E++ + + LE+VI ++DVLYVTRIQKERFPDE+EY KV
Sbjct: 183 LISPEALALPEDIIEDVSAE----IRRARLEEVISEIDVLYVTRIQKERFPDEEEYRKVS 238
Query: 246 GSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVL 305
GSY++ + L+ AKD + +MHPLPRVDEIHP VD+TKHA YF+Q F GVPVRMA+L+ V+
Sbjct: 239 GSYRITAETLKSAKDSMIVMHPLPRVDEIHPSVDSTKHARYFQQSFYGVPVRMAILSEVM 298
>sp|Q58976|PYRB_METJA ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|2127771|pir||D64497 aspartate
carbamoyltransferase (EC 2.1.3.2) catalytic chain -
Methanococcus jannaschii >gi|1500476|gb|AAB99601.1|
(U67598) aspartate carbamoyltransferase catalytic chain
(pyrB) [Methanococcus jannaschii]
Length = 306
Score = 349 bits (885), Expect = 3e-95
Identities = 176/297 (59%), Positives = 226/297 (75%), Gaps = 3/297 (1%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +IS++D KE+I +L A ++E L K L+ +GKILAT+F+EPSTRTRLSFE+A
Sbjct: 2 KHLISMKDIGKEEILEILDEARKMEELLNTKRPLKLLEGKILATVFYEPSTRTRLSFETA 61
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
M RLGG VI + +SSV KGESL DTI+ + Y D+IV+RHP EGAARLA+E ++VP+
Sbjct: 62 MKRLGGEVITMTDLKSSSVAKGESLIDTIRVISGYADIIVLRHPSEGAARLASEYSQVPI 121
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDVEL 184
INAGDGSNQHPTQTLLDLYTI +E GRIDG+KI +GDLKYGRTVHSL AL+ F +VE+
Sbjct: 122 INAGDGSNQHPTQTLLDLYTIMREIGRIDGIKIAFVGDLKYGRTVHSLVYALSLFENVEM 181
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
Y +SP+ LR+P+ I+E+L+ K +K E +L+D+ +DVLYVTRIQKERFPD EY KV
Sbjct: 182 YFVSPKELRLPKDIIEDLKAKNIKFYEKESLDDLDDDIDVLYVTRIQKERFPDPNEYEKV 241
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
KGSY++ + +E K IMHPLPRVDEI +VD+ A YF+Q F G+PVRMA+L
Sbjct: 242 KGSYKIKREYVEGKK--FIIMHPLPRVDEIDYDVDDLPQAKYFKQSFYGIPVRMAIL 296
>sp|O27464|PYRB_METTH ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433582|pir||C69055 aspartate
carbamoyltransferase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622525|gb|AAB85890.1| (AE000903) aspartate
carbamoyltransferase [Methanobacterium
thermoautotrophicum]
Length = 312
Score = 344 bits (874), Expect = 6e-94
Identities = 171/299 (57%), Positives = 222/299 (74%), Gaps = 2/299 (0%)
Query: 7 DVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAM 66
+VISI+DF +EDIE +L AE++E + +GKIL +F+EPSTRTRLSFE+AM
Sbjct: 4 NVISIKDFKREDIEFILREAEKMEPFASGEKSSSALRGKILGMMFYEPSTRTRLSFETAM 63
Query: 67 HRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPVI 126
RLGG V+GFA+ +S KGESL DT + Y D IVIRH EGAAR ++V +VPVI
Sbjct: 64 KRLGGDVVGFADTGATSAVKGESLADTAMMLSAYSDAIVIRHNLEGAARYISDVVDVPVI 123
Query: 127 NAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELYL 186
NAGDG+ QHPTQTLLDLYT+K+ FGRI L++ L+GDLKYGRTVHSLA AL + +
Sbjct: 124 NAGDGAGQHPTQTLLDLYTMKRFFGRIGSLRVALVGDLKYGRTVHSLAYALAVFGASMSF 183
Query: 187 ISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVKG 246
+SP +LRMP +I+ +LR G++V ET L+DVI ++DVLYVTRIQKERFPD +EY +++G
Sbjct: 184 VSPPVLRMPDNIIHDLRRAGVEVKETERLDDVIDEVDVLYVTRIQKERFPDPEEYSRIRG 243
Query: 247 SYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVL 305
+Y ++ + A +L +MHPLPR+DEI PEVD+ A+YFRQ F GVPVRMALL L++
Sbjct: 244 AYHIDGSTV--ADRDLIVMHPLPRIDEISPEVDSLPQAMYFRQAFYGVPVRMALLRLLI 300
>gb|AAG20942.1| (AE005160) aspartate carbamoyltransferase catalytic subunit; PyrB
[Halobacterium sp. NRC-1]
Length = 341
Score = 336 bits (852), Expect = 2e-91
Identities = 166/299 (55%), Positives = 222/299 (73%), Gaps = 4/299 (1%)
Query: 8 VISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMH 67
+I+ + S+ DIETVL A ++ + + + +L LFFEPSTRT++SF++AM
Sbjct: 37 IITSKQLSRADIETVLDRAAEIDAD--PSAFADRYENTVLGLLFFEPSTRTKMSFDTAMK 94
Query: 68 RLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPVIN 127
RLGG ++ +SSVKKGE+L DT++ +E Y D +V+RHP +GAA++A+E +VP++N
Sbjct: 95 RLGGDIVDMGSVDSSSVKKGETLADTVRVIEGYADALVLRHPNQGAAQMASEFVDVPLLN 154
Query: 128 AGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELYLI 187
AGDG+ HPTQTLLDLYTI++ G ++ L IG++GDLKYGRTVHSL+ ALT +DV+ + I
Sbjct: 155 AGDGAGHHPTQTLLDLYTIRENAG-LEDLTIGIMGDLKYGRTVHSLSRALTNFDVDQHFI 213
Query: 188 SPELLRMPRHIVEEL-REKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVKG 246
SPE L++PR +V +L +E G +V E + EDV+ +LD+LYVTRIQ+ERFPDE EY KV G
Sbjct: 214 SPESLQLPRDVVYDLEQESGTRVREHDSFEDVLPELDILYVTRIQRERFPDENEYQKVAG 273
Query: 247 SYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVL 305
YQ+ LE AKD+L IMHPLPRVDEI PE+D+T HA YF Q NGVPVRMALL LVL
Sbjct: 274 EYQLTATHLEAAKDDLTIMHPLPRVDEIAPEIDDTDHAAYFEQAHNGVPVRMALLDLVL 332
>emb|CAC11715.1| (AL445064) probable aspartate carbamoyltransferase, catalytic chain
[Thermoplasma acidophilum]
Length = 305
Score = 331 bits (840), Expect = 6e-90
Identities = 162/303 (53%), Positives = 221/303 (72%), Gaps = 1/303 (0%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
K R V+SI D +D+ + ++ + + +++ G + + +I+ATLF+EPSTRTRLSFE
Sbjct: 3 KNRSVVSIEDVDIDDLNDLFDLSDSMLKTIEKGGSTDLLRNRIMATLFYEPSTRTRLSFE 62
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
SAMHRLGG+VI ++ TSSV KGE+L DTI+ Y D+IVIRHP EGAARLA++ A
Sbjct: 63 SAMHRLGGSVITVSDVKTSSVAKGETLADTIRMASSYSDIIVIRHPLEGAARLASKFANK 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PVINAGDGS QHPTQT+LDLYTIK+E G IDG I ++GDL+YGRT+HSL AL+ +DV
Sbjct: 123 PVINAGDGSGQHPTQTILDLYTIKRETGSIDGKTITMVGDLRYGRTIHSLIIALSRFDVR 182
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLK 243
+ L+SP++L++P +++ ++ ++ +++E L VI DVLYVTRIQKERF D+ EY
Sbjct: 183 INLVSPQILKLPEYVLTKIGDRS-RIMEYDDLSKVIEDTDVLYVTRIQKERFSDQNEYQS 241
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
V GSY V+ ++ + K + IMHPLPR+DEI PEVD A YF+Q + GVPVRMAL+
Sbjct: 242 VIGSYSVDRDLVSRMKKDAIIMHPLPRIDEIKPEVDELPQARYFKQAYYGVPVRMALIYR 301
Query: 304 VLG 306
+LG
Sbjct: 302 ILG 304
>pir||A81238 aspartate carbamoyltransferase (EC 2.1.3.2) catalytic chain NMA0168
[imported] - Neisseria meningitidis (group B strain
MD58, group A strain Z2491) >gi|7225321|gb|AAF40565.1|
(AE002369) aspartate carbamoyltransferase, catalytic
subunit [Neisseria meningitidis MC58]
>gi|7378939|emb|CAB83482.1| (AL162752) aspartate
carbamoyltransferase catalytic chain [Neisseria
meningitidis Z2491]
Length = 306
Score = 321 bits (814), Expect = 6e-87
Identities = 163/298 (54%), Positives = 216/298 (71%), Gaps = 5/298 (1%)
Query: 8 VISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMH 67
+ISI D S+E +E +L TA +L+ +G L +GK++ + FFEPSTRTRLSFE+A+
Sbjct: 10 IISISDLSREQLECLLQTALKLKAH--PRGDL--LEGKLIGSCFFEPSTRTRLSFETAVQ 65
Query: 68 RLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPVIN 127
RLGG VIGF++ + +S KKGE+L DT + + Y D I+ RHPK+GAAR+AAE + VPVIN
Sbjct: 66 RLGGKVIGFSDGANTSAKKGETLADTARIISGYTDAIIQRHPKDGAARVAAEFSRVPVIN 125
Query: 128 AGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELYLI 187
AGDG+NQHP+QTLLDL TI + GR+D LKI + GDLKYGRTVHSL +AL ++ E +
Sbjct: 126 AGDGTNQHPSQTLLDLVTIYETQGRLDKLKIAMAGDLKYGRTVHSLCQALKRWNCEFAFV 185
Query: 188 SPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVKGS 247
SP L MP +I EEL E G + +LE+ D+LY+TR+Q+ERF DEQE+ K++G
Sbjct: 186 SPPSLAMPDYITEELDEAGCRYRILGSLEEAAEWADILYMTRVQRERF-DEQEFAKIQGK 244
Query: 248 YQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVL 305
+ + +L +AK LR++HPLPRVDEIHP+VD T HA YF Q NGV RMA+L+LVL
Sbjct: 245 FNLEASMLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSLVL 302
>pdb|1RAA|A Chain A, Aspartate Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Fast
Cooling Sa Refinement After 250 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494500|pdb|1RAA|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Fast Cooling Sa Refinement After 250 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494502|pdb|1RAB|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Slow
Cooling Sa Refinement After 250 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494504|pdb|1RAB|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Slow Cooling Sa Refinement After 250 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494506|pdb|1RAC|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Fast
Cooling Sa Refinement After 500 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494508|pdb|1RAC|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Fast Cooling Sa Refinement After 500 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494510|pdb|1RAD|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Slow
Cooling Sa Refinement After 500 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494512|pdb|1RAD|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Slow Cooling Sa Refinement After 500 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494514|pdb|1RAE|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Fast
Cooling Sa Refinement After 750 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494516|pdb|1RAE|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Fast Cooling Sa Refinement After 750 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494518|pdb|1RAF|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Slow
Cooling Sa Refinement After 750 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494520|pdb|1RAF|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Slow Cooling Sa Refinement After 750 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494522|pdb|1RAG|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Fast
Cooling Sa Refinement After 1000 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494524|pdb|1RAG|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Fast Cooling Sa Refinement After 1000 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494526|pdb|1RAH|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp (Slow
Cooling Sa Refinement After 1000 Steps Of Equilibration
Of Preliminary Refined Model) >gi|494528|pdb|1RAH|C
Chain C, Aspartate Transcarbamoylase (E.C.2.1.3.2)
(Aspartate Carbamoyltransferase) (T State) Complexed
With Ctp (Slow Cooling Sa Refinement After 1000 Steps Of
Equilibration Of Preliminary Refined Model)
>gi|494530|pdb|1RAI|A Chain A, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp
(Refinement 9: Final Refined Structure)
>gi|494532|pdb|1RAI|C Chain C, Aspartate
Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) (T State) Complexed With Ctp
(Refinement 9: Final Refined Structure)
>gi|5107741|pdb|3CSU|C Chain C, Catalytic Trimer Of
Escherichia Coli Aspartate Transcarbamoylase
>gi|5107739|pdb|3CSU|A Chain A, Catalytic Trimer Of
Escherichia Coli Aspartate Transcarbamoylase
>gi|5107740|pdb|3CSU|B Chain B, Catalytic Trimer Of
Escherichia Coli Aspartate Transcarbamoylase
Length = 310
Score = 310 bits (787), Expect = 9e-84
Identities = 162/303 (53%), Positives = 219/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 7 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 62
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 63 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 123 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 182
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP++I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 183 RFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 241
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 242 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 301
Query: 303 LVL 305
LVL
Sbjct: 302 LVL 304
>gb|AAA24476.1| (K01472) aspartate transcarbamoylase catalytic chain (pyrB)
[Escherichia coli]
Length = 311
Score = 310 bits (787), Expect = 9e-84
Identities = 162/303 (53%), Positives = 219/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 8 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 63
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 64 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 124 PVLNAGDGSNQHPTQTLLDLFTIQETEGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 183
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP++I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 184 RFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 242
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 243 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 302
Query: 303 LVL 305
LVL
Sbjct: 303 LVL 305
>sp|P00479|PYRB_ECOLI ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (ASPARTATE
TRANSCARBAMYLASE) (ATCASE) >gi|7427896|pir||DTECC
aspartate carbamoyltransferase (EC 2.1.3.2) catalytic
chain - Escherichia coli (strain K-12)
>gi|8569590|pdb|1EKX|A Chain A, The Isolated,
Unregulated Catalytic Trimer Of Aspartate
Transcarbamoylase Complexed With Bisubstrate Analog Pala
(N (Phosphonacetyl)-L-Aspartate) >gi|8569591|pdb|1EKX|B
Chain B, The Isolated, Unregulated Catalytic Trimer Of
Aspartate Transcarbamoylase Complexed With Bisubstrate
Analog Pala (N (Phosphonacetyl)-L-Aspartate)
>gi|8569592|pdb|1EKX|C Chain C, The Isolated,
Unregulated Catalytic Trimer Of Aspartate
Transcarbamoylase Complexed With Bisubstrate Analog Pala
(N (Phosphonacetyl)-L-Aspartate)
>gi|2367364|gb|AAC77202.1| (AE000495) aspartate
carbamoyltransferase, catalytic subunit [Escherichia
coli K12]
Length = 311
Score = 310 bits (787), Expect = 9e-84
Identities = 162/303 (53%), Positives = 219/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 8 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 63
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 64 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 124 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 183
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP++I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 184 RFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 242
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 243 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 302
Query: 303 LVL 305
LVL
Sbjct: 303 LVL 305
>pdb|1D09|A Chain A, Aspartate Transcarbamoylase Complexed With
N-Phosphonacetyl- L-Aspartate (Pala)
>gi|6980788|pdb|1D09|C Chain C, Aspartate
Transcarbamoylase Complexed With N-Phosphonacetyl-
L-Aspartate (Pala)
Length = 310
Score = 310 bits (786), Expect = 1e-83
Identities = 162/303 (53%), Positives = 218/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 7 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 62
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 63 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 123 PVLNAGDGSNQHPTQTLLDLFTIQQTQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 182
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP +I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 183 RFYFIAPDALAMPEYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 241
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 242 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 301
Query: 303 LVL 305
LVL
Sbjct: 302 LVL 304
>sp|P96174|PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (ASPARTATE
TRANSCARBAMYLASE) (ATCASE) >gi|11257123|pir||T48882
aspartate carbamoyltransferase (EC 2.1.3.2) catalytic
chain [validated] - Vibrio sp
>gi|1708787|emb|CAA70923.1| (Y09786) aspartate
carbamoyltransferase (ATCase) catalytic chain (c)
[Vibrio sp.]
Length = 310
Score = 310 bits (785), Expect = 2e-83
Identities = 162/302 (53%), Positives = 216/302 (70%), Gaps = 7/302 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ ++SI D S+ ++E ++ TA +L K++ Q E K K++A+ FFE STRTRLSFE+A
Sbjct: 8 KHIVSINDISRNELELIVKTAAKL----KKQPQPELLKNKVIASCFFEASTRTRLSFETA 63
Query: 66 MHRLGGAVIGFAEAS-TSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
+ RLGG VIGF AS TS KKGE+L D+I + Y D V+RHP+EGAARLA+E + VP
Sbjct: 64 IQRLGGTVIGFDNASNTSLAKKGETLADSISVISSYVDAFVMRHPQEGAARLASEFSNVP 123
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDVE 183
VIN GDGSNQHPTQTLLDL++I + G +D L I L+GDLKYGRTVHSLA+AL F +
Sbjct: 124 VINGGDGSNQHPTQTLLDLFSIYETQGCLDNLNIALVGDLKYGRTVHSLAQALAKFSGCK 183
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLK 243
Y I+P+ L MP +I +EL E + ++E+V+ ++DVLY+TR+QKERF DE EY
Sbjct: 184 FYFIAPDALAMPEYICDELDEHNVSYACYNSIEEVVPEIDVLYMTRVQKERF-DETEYQH 242
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
+K + ++ L+ AKD L+++HPLPRVDEI +VD T +A YF+Q NGV R ALLAL
Sbjct: 243 MKAGFILSASSLKHAKDNLKVLHPLPRVDEIAVDVDKTPYAYYFQQAENGVYAREALLAL 302
Query: 304 VL 305
VL
Sbjct: 303 VL 304
>pdb|8ATC|A Chain A, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (R State) (E.C.2.1.3.2) Complex With
N-Phosphonacetyl-L-Aspartate (PALA)
>gi|231288|pdb|8ATC|C Chain C, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (R
State) (E.C.2.1.3.2) Complex With
N-Phosphonacetyl-L-Aspartate (PALA)
>gi|3891867|pdb|1NBE|A Chain A, Aspartate
Transcarbomylase Regulatory Chain Mutant (T82a)
>gi|3891869|pdb|1NBE|C Chain C, Aspartate
Transcarbomylase Regulatory Chain Mutant (T82a)
>gi|230953|pdb|4AT1|A Chain A, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (T
State) (E.C.2.1.3.2) Complex With Adenosine
5-Prime-Triphosphate (ATP) >gi|230955|pdb|4AT1|C Chain
C, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (T State) (E.C.2.1.3.2) Complex With
Adenosine 5-Prime-Triphosphate (ATP)
>gi|231113|pdb|5AT1|A Chain A, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (T
State) (E.C.2.1.3.2) Complex With Cytidine
5-Prime-Triphosphate (CTP) >gi|231115|pdb|5AT1|C Chain
C, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (T State) (E.C.2.1.3.2) Complex With
Cytidine 5-Prime-Triphosphate (CTP)
>gi|231193|pdb|6AT1|A Chain A, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (T
State) (E.C.2.1.3.2) >gi|231195|pdb|6AT1|C Chain C,
Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (T State) (E.C.2.1.3.2)
>gi|231282|pdb|8AT1|A Chain A, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (R
State) (E.C.2.1.3.2) Complex With Phosphonoacetamide
(PAM), Malonate (MAL), And Cytidine 5-Prime-Triphosphate
(CTP) >gi|231284|pdb|8AT1|C Chain C, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (R
State) (E.C.2.1.3.2) Complex With Phosphonoacetamide
(PAM), Malonate (MAL), And Cytidine 5-Prime-Triphosphate
(CTP) >gi|231243|pdb|7AT1|A Chain A, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (R
State) (E.C.2.1.3.2) Complex With Phosphonoacetamide
(PAM), Malonate (MAL), And Adenosine
5-Prime-Triphosphate (ATP) >gi|231245|pdb|7AT1|C Chain
C, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (R State) (E.C.2.1.3.2) Complex With
Phosphonoacetamide (PAM), Malonate (MAL), And Adenosine
5-Prime-Triphosphate (ATP) >gi|229685|pdb|1AT1|A Chain
A, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (R State) (E.C.2.1.3.2) Complex With
Phosphonoacetamide (PAM) And Malonate (MAL)
>gi|229687|pdb|1AT1|C Chain C, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (R
State) (E.C.2.1.3.2) Complex With Phosphonoacetamide
(PAM) And Malonate (MAL) >gi|230425|pdb|2AT1|A Chain A,
Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (R State) (E.C.2.1.3.2) Complex With
Phosphonoacetamide (PAM) And Malonate (MAL)
>gi|230427|pdb|2AT1|C Chain C, Aspartate
Carbamoyltransferase (Aspartate Transcarbamylase) (R
State) (E.C.2.1.3.2) Complex With Phosphonoacetamide
(PAM) And Malonate (MAL) >gi|230808|pdb|3AT1|A Chain A,
Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (T State) (E.C.2.1.3.2) Complex With
Phosphonoacetamide >gi|230810|pdb|3AT1|C Chain C,
Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (T State) (E.C.2.1.3.2) Complex With
Phosphonoacetamide
Length = 310
Score = 309 bits (783), Expect = 3e-83
Identities = 161/303 (53%), Positives = 218/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSF+++
Sbjct: 7 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFQTS 62
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 63 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 123 PVLNAGDGSNQHPTQTLLDLFTIQQTEGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 182
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP +I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 183 RFYFIAPDALAMPEYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 241
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 242 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 301
Query: 303 LVL 305
LVL
Sbjct: 302 LVL 304
>pdb|9ATC|A Chain A, Atcase Y165f Mutant
Length = 310
Score = 309 bits (783), Expect = 3e-83
Identities = 161/303 (53%), Positives = 219/303 (72%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 7 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 62
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 63 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLK+GRTVHSL +AL +D
Sbjct: 123 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKFGRTVHSLTQALAKFDGN 182
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP++I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 183 RFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 241
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 242 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 301
Query: 303 LVL 305
LVL
Sbjct: 302 LVL 304
>pir||H82066 aspartate carbamoyltransferase, catalytic chain VC2510 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9657093|gb|AAF95652.1| (AE004321) aspartate
carbamoyltransferase, catalytic subunit [Vibrio
cholerae]
Length = 330
Score = 309 bits (782), Expect = 4e-83
Identities = 163/303 (53%), Positives = 216/303 (70%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI + S+ ++E ++ TA +LK + E K K++A+ FFEPSTRTRLSFE+A
Sbjct: 29 KHIISIAELSRAELELIVKTAG----QLKAQPNPELIKHKVVASCFFEPSTRTRLSFETA 84
Query: 66 MHRLGGAVIGFAEA-STSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE-V 123
+ R+GG+VIGF +TS KKGE+L D+++ + Y D V+RHP+EGAARLA+E + V
Sbjct: 85 IQRIGGSVIGFDNGGNTSLAKKGETLADSVRVISSYVDAFVMRHPQEGAARLASEFSNGV 144
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PVINAGDGSNQHP+QTLLDLY+I + GR+D L + +GDLKYGRTVHSLA+AL +D
Sbjct: 145 PVINAGDGSNQHPSQTLLDLYSIFETQGRLDNLDVAFVGDLKYGRTVHSLAQALAKFDNN 204
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y ++PE L MP +I EEL E G+K + +E VI +LD+LY+TR+QKERF DE EY
Sbjct: 205 RFYFVAPEALAMPDYICEELDEAGVKYQVFSDMESVIPELDILYMTRVQKERF-DESEYA 263
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
+K +Y + L A+ L+++HPLPRVDEI +VD T HA YF QV NGV R ALLA
Sbjct: 264 HIKSAYILTAAHLSDARSNLKVLHPLPRVDEITTDVDKTPHAYYFEQVENGVYAREALLA 323
Query: 303 LVL 305
LVL
Sbjct: 324 LVL 326
>sp|P20054|PYR1_DICDI PROTEIN PYR1-3 [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ]
Length = 2185
Score = 308 bits (781), Expect = 5e-83
Identities = 150/302 (49%), Positives = 210/302 (68%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ + S++ F+++ + + A + +K G + KGK+LATLF+EPSTRT+ SF +
Sbjct: 1882 GKHIFSVKQFNRKQLHALFGIAHEMRILVKRSGGSDLLKGKVLATLFYEPSTRTQCSFTA 1941
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGG+V+ S SSV KGES+ DTI+T+E YCD + +RHP G+ A +VA+ P
Sbjct: 1942 AMQRLGGSVVTVDNVS-SSVAKGESIADTIQTLESYCDAVCMRHPAVGSVESAIQVAKKP 2000
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
+INAGDG +HPTQ LLD++TI++E G ++GL I ++GDLK+GRTVHSL L Y V++
Sbjct: 2001 IINAGDGVGEHPTQALLDVFTIREELGTVNGLTITVVGDLKHGRTVHSLVRLLANYQVKI 2060
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
+SP L MP I++EL EKG++ E T +E ++ +VLYVTR+QKERF +EY KV
Sbjct: 2061 NYVSPSSLSMPTEIIKELNEKGIEQKEYTNIESILPTTNVLYVTRVQKERFQSIEEYEKV 2120
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
K S+ + L KA D + +MHPLPR++EI PEVD+ A YFRQ+ NG+ VRM+LLALV
Sbjct: 2121 KDSFIITPHTLTKASDNMIVMHPLPRINEISPEVDSDPRAAYFRQMENGLYVRMSLLALV 2180
Query: 305 LG 306
G
Sbjct: 2181 FG 2182
>emb|CAA32782.1| (X14634) PYR1-3B multifunctional enzyme (1014 AA) [Dictyostelium
discoideum]
Length = 1014
Score = 308 bits (781), Expect = 5e-83
Identities = 150/302 (49%), Positives = 210/302 (68%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ + S++ F+++ + + A + +K G + KGK+LATLF+EPSTRT+ SF +
Sbjct: 711 GKHIFSVKQFNRKQLHALFGIAHEMRILVKRSGGSDLLKGKVLATLFYEPSTRTQCSFTA 770
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGG+V+ S SSV KGES+ DTI+T+E YCD + +RHP G+ A +VA+ P
Sbjct: 771 AMQRLGGSVVTVDNVS-SSVAKGESIADTIQTLESYCDAVCMRHPAVGSVESAIQVAKKP 829
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
+INAGDG +HPTQ LLD++TI++E G ++GL I ++GDLK+GRTVHSL L Y V++
Sbjct: 830 IINAGDGVGEHPTQALLDVFTIREELGTVNGLTITVVGDLKHGRTVHSLVRLLANYQVKI 889
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
+SP L MP I++EL EKG++ E T +E ++ +VLYVTR+QKERF +EY KV
Sbjct: 890 NYVSPSSLSMPTEIIKELNEKGIEQKEYTNIESILPTTNVLYVTRVQKERFQSIEEYEKV 949
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
K S+ + L KA D + +MHPLPR++EI PEVD+ A YFRQ+ NG+ VRM+LLALV
Sbjct: 950 KDSFIITPHTLTKASDNMIVMHPLPRINEISPEVDSDPRAAYFRQMENGLYVRMSLLALV 1009
Query: 305 LG 306
G
Sbjct: 1010 FG 1011
>pir||QZDOP3 pyrimidine synthesis protein PYR1-3 - slime mold (Dictyostelium
discoideum) (fragments)
Length = 1481
Score = 308 bits (781), Expect = 5e-83
Identities = 150/302 (49%), Positives = 210/302 (68%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ + S++ F+++ + + A + +K G + KGK+LATLF+EPSTRT+ SF +
Sbjct: 1178 GKHIFSVKQFNRKQLHALFGIAHEMRILVKRSGGSDLLKGKVLATLFYEPSTRTQCSFTA 1237
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGG+V+ S SSV KGES+ DTI+T+E YCD + +RHP G+ A +VA+ P
Sbjct: 1238 AMQRLGGSVVTVDNVS-SSVAKGESIADTIQTLESYCDAVCMRHPAVGSVESAIQVAKKP 1296
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
+INAGDG +HPTQ LLD++TI++E G ++GL I ++GDLK+GRTVHSL L Y V++
Sbjct: 1297 IINAGDGVGEHPTQALLDVFTIREELGTVNGLTITVVGDLKHGRTVHSLVRLLANYQVKI 1356
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
+SP L MP I++EL EKG++ E T +E ++ +VLYVTR+QKERF +EY KV
Sbjct: 1357 NYVSPSSLSMPTEIIKELNEKGIEQKEYTNIESILPTTNVLYVTRVQKERFQSIEEYEKV 1416
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
K S+ + L KA D + +MHPLPR++EI PEVD+ A YFRQ+ NG+ VRM+LLALV
Sbjct: 1417 KDSFIITPHTLTKASDNMIVMHPLPRINEISPEVDSDPRAAYFRQMENGLYVRMSLLALV 1476
Query: 305 LG 306
G
Sbjct: 1477 FG 1478
>pdb|1EZZ|A Chain A, Crystal Structure Of E. Coli Aspartate Transcarbamoylase
P268a Mutant In The T-State >gi|11513489|pdb|1EZZ|C
Chain C, Crystal Structure Of E. Coli Aspartate
Transcarbamoylase P268a Mutant In The T-State
>gi|11513494|pdb|1F1B|A Chain A, Crystal Structure Of E.
Coli Aspartate Transcarbamoylase P268a Mutant In The
R-State In The Presence Of N- Phosphonacetyl-L-Aspartate
>gi|11513496|pdb|1F1B|C Chain C, Crystal Structure Of E.
Coli Aspartate Transcarbamoylase P268a Mutant In The
R-State In The Presence Of N- Phosphonacetyl-L-Aspartate
Length = 310
Score = 307 bits (779), Expect = 8e-83
Identities = 161/303 (53%), Positives = 218/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 7 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 62
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 63 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 123 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 182
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP++I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 183 RFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 241
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPL RVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 242 NVKAQFVLRASDLHNAKANMKVLHPLARVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 301
Query: 303 LVL 305
LVL
Sbjct: 302 LVL 304
>gb|AAA97142.1| (U14003) aspartate carbomoyltransferase catalytic subunit
[Escherichia coli]
Length = 311
Score = 307 bits (778), Expect = 1e-82
Identities = 161/303 (53%), Positives = 218/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 8 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 63
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 64 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 124 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 183
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L M ++I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 184 RFYFIAPDALAMRQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 242
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 243 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 302
Query: 303 LVL 305
LVL
Sbjct: 303 LVL 305
>pdb|1ACM|A Chain A, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) Mutant With Arg A 54 (Catalytic Chain)
Replaced By Ala And Arg C 54 (Catalytic Chain) Replaced
By Ala (R(A)54A,R(C)54A) (R State) (E.C.2.1.3.2) Complex
With N-Phosphonacetyl-L-Asparta> >gi|229666|pdb|1ACM|C
Chain C, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) Mutant With Arg A 54 (Catalytic Chain)
Replaced By Ala And Arg C 54 (Catalytic Chain) Replaced
By Ala (R(A)54A,R(C)54A) (R State) (E.C.2.1.3.2) Complex
With N-Phosphonacetyl-L-Asparta>
Length = 310
Score = 307 bits (777), Expect = 1e-82
Identities = 160/303 (52%), Positives = 217/303 (70%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE ST TRLSF+++
Sbjct: 7 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTATRLSFQTS 62
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 63 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 123 PVLNAGDGSNQHPTQTLLDLFTIQQTEGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 182
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP +I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 183 RFYFIAPDALAMPEYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERL-DPSEYA 241
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ R ALLA
Sbjct: 242 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLA 301
Query: 303 LVL 305
LVL
Sbjct: 302 LVL 304
>gb|AAA24474.1| (J01670) aspartate transcarbamoylase catalytic chain [Escherichia
coli]
Length = 311
Score = 305 bits (774), Expect = 3e-82
Identities = 160/303 (52%), Positives = 218/303 (71%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSF+++
Sbjct: 8 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFQTS 63
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + V
Sbjct: 64 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L + ++GDLKYGRTVHSL +AL +D
Sbjct: 124 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGN 183
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP++I++ L EKG+ +++E+V+ ++D+LY+TR+QKER D EY
Sbjct: 184 RFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMVEVDILYMTRVQKERL-DPSEYA 242
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L AK ++++HPLPRVDEI +VD T HA YF+Q NG+ ALLA
Sbjct: 243 NVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFALQALLA 302
Query: 303 LVL 305
LVL
Sbjct: 303 LVL 305
>sp|P08420|PYRB_SALTY ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (ASPARTATE
TRANSCARBAMYLASE) (ATCASE)
Length = 310
Score = 302 bits (766), Expect = 3e-81
Identities = 162/303 (53%), Positives = 217/303 (71%), Gaps = 9/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 8 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 63
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + +V
Sbjct: 64 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGQV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDV 182
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L I ++GDLKYGRTVHSLA+ L F
Sbjct: 124 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHIAMVGDLKYGRTVHSLAQTLAKFSGN 183
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP++I++ L EKGM ++E+V+ +D+LY+TR+QKER D EY
Sbjct: 184 RFYFIAPDALAMPQYILDMLDEKGMAWSLHGSIEEVMADVDILYMTRVQKERL-DPSEYA 242
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + V L A++ ++++HPLPR+DEI +VD T HA YF+Q NG+ ALLA
Sbjct: 243 NVKAQF-VLRPDLNGARENMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFAAQALLA 301
Query: 303 LVL 305
LVL
Sbjct: 302 LVL 304
>sp|Q91437|PYR1_SQUAC CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ] >gi|2118285|pir||A57541 pyrimidine
synthesis multifunctional protein CAD - spiny dogfish
>gi|951096|gb|AAA74569.1| (U18868) multifunctional
protein CAD [Squalus acanthias]
Length = 2242
Score = 300 bits (761), Expect = 1e-80
Identities = 149/302 (49%), Positives = 214/302 (70%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++S++ F+K+ + + A L +++ L+ KGK++A++F+E STRT SF +
Sbjct: 1940 GQHILSVKRFTKDQLSHLFNVAHNLRLTVQKDRSLDILKGKVMASMFYEVSTRTSSSFRA 1999
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AMHRLGG+VI F+EA TSSV+KGESL D+++T+ Y DV+V+RHP+ GA LAA+ + P
Sbjct: 2000 AMHRLGGSVIHFSEA-TSSVQKGESLLDSVQTMSCYVDVVVLRHPEPGAVELAAKHSRKP 2058
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
+INAGDG +HPTQ LLD++TI++E G ++G+ I ++GDLK+GRTVHSLA LT Y V L
Sbjct: 2059 IINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLAYLLTLYRVNL 2118
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
++P LRMP +I+ L +G+K E +LE+ + DVLY+TRIQKERF E+EY
Sbjct: 2119 RYVTPRNLRMPPNIIRFLASRGIKQEEFDSLEEALPDTDVLYMTRIQKERFASEEEYEAC 2178
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
G + + ++ K K ++ +MHPLPRV+E+ EVD+ A YFRQ NG+ VRMALLA V
Sbjct: 2179 FGQFILTPHIMTKGKKKMVVMHPLPRVNEVSVEVDSDPRAAYFRQAENGMYVRMALLATV 2238
Query: 305 LG 306
LG
Sbjct: 2239 LG 2240
>pir||C72547 probable aspartate carbamoyltransferase catalytic chain APE1663 -
Aeropyrum pernix (strain K1) >gi|5105351|dbj|BAA80664.1|
(AP000062) 312aa long hypothetical aspartate
carbamoyltransferase catalytic chain [Aeropyrum pernix]
Length = 312
Score = 300 bits (761), Expect = 1e-80
Identities = 159/305 (52%), Positives = 209/305 (68%), Gaps = 6/305 (1%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
+KGRDVISI DF++ D+E + A+ +E + K GK++A FFEPSTRTRLSF
Sbjct: 10 FKGRDVISITDFTRGDLELLFRQADVIESKAGSKP----LDGKVVALAFFEPSTRTRLSF 65
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+A+ RLGG+ + + SV KGE+L DTI ++ Y D IVIRH EGAA AAEVAE
Sbjct: 66 ETAVKRLGGSTLLISGEEAISVAKGENLADTITMLDSYADAIVIRHRYEGAALYAAEVAE 125
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
PVIN GDG HPTQ +LDLYT+ FG +DGL G+LGDL+YGR S L+ ++
Sbjct: 126 KPVINGGDGRQHHPTQAMLDLYTVYSLFGTVDGLTYGVLGDLRYGRAASSFILGLSLFNP 185
Query: 183 -ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEY 241
+YLISP LR R ++E L ++G+ E L+DV+G+LDVLYVTRIQKER PD +EY
Sbjct: 186 RHVYLISPPQLRARREVLEALEKRGVPYTEVERLQDVLGELDVLYVTRIQKERIPDPREY 245
Query: 242 LKVKGSYQVNLKVLEK-AKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
++GSY+V L +LE AK+ L+++HPLPRVDEI VD++++ YF Q GV VRMAL
Sbjct: 246 ESLRGSYRVTLDLLESFAKESLKVLHPLPRVDEIDFSVDSSRYQAYFTQARLGVRVRMAL 305
Query: 301 LALVL 305
+ LV+
Sbjct: 306 MNLVM 310
>gb|AAA68280.1| (M27174) carbamyl phosphate synthetase [Saccharomyces cerevisiae]
Length = 2214
Score = 295 bits (747), Expect = 5e-79
Identities = 148/306 (48%), Positives = 210/306 (68%), Gaps = 2/306 (0%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++GR ++SI+ F + D + A A+ L + +G L+ KG ++ T+FFEPSTRT SF
Sbjct: 1908 FRGRHILSIKQFKRSDFHVLFAVAQELRARVAREGVLDLMKGHVITTIFFEPSTRTCSSF 1967
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
+AM RLGG ++ SSVKKGE+L+DTI+T+ Y D IV+RH +E + +AA+ +
Sbjct: 1968 IAAMERLGGRIVN-VNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAKYSP 2026
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VP+IN G+GS +HPTQ LDL+TI++E G ++G+ + +GDLK+GRTVHSL L Y V
Sbjct: 2027 VPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQV 2086
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFPDEQEY 241
+ L+SP LR+P + EELR+ G+ VE+ L +I K DVLY TR+Q+ERF +EY
Sbjct: 2087 RINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEY 2146
Query: 242 LKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
++K +Y V+ K+L AK+ + IMHPLPRV+EI EVD A YFRQ+ G+ VRMALL
Sbjct: 2147 ARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALL 2206
Query: 302 ALVLGV 307
A+V+GV
Sbjct: 2207 AMVMGV 2212
>emb|CAA60825.1| (X87371) carbamyl phosphate synthetase [Saccharomyces cerevisiae]
Length = 2040
Score = 294 bits (746), Expect = 6e-79
Identities = 148/306 (48%), Positives = 210/306 (68%), Gaps = 2/306 (0%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++GR ++SI+ F + D + A A+ L + +G L+ KG ++ T+FFEPSTRT SF
Sbjct: 1734 FRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLDLMKGHVITTIFFEPSTRTCSSF 1793
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
+AM RLGG ++ SSVKKGE+L+DTI+T+ Y D IV+RH +E + +AA+ +
Sbjct: 1794 IAAMERLGGRIVN-VNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAKYSP 1852
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VP+IN G+GS +HPTQ LDL+TI++E G ++G+ + +GDLK+GRTVHSL L Y V
Sbjct: 1853 VPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQV 1912
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFPDEQEY 241
+ L+SP LR+P + EELR+ G+ VE+ L +I K DVLY TR+Q+ERF +EY
Sbjct: 1913 RINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEY 1972
Query: 242 LKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
++K +Y V+ K+L AK+ + IMHPLPRV+EI EVD A YFRQ+ G+ VRMALL
Sbjct: 1973 ARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALL 2032
Query: 302 ALVLGV 307
A+V+GV
Sbjct: 2033 AMVMGV 2038
>gi|6322331 carbamoyl-phophate synthetase, aspartate transcarbamylase, and
glutamine amidotransferase; Ura2p [Saccharomyces
cerevisiae] >gi|1172782|sp|P07259|PYR1_YEAST URA1 PROTEIN
[INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ]
>gi|1070511|pir||QZBYU2 pyrimidine synthesis protein URA2
- yeast (Saccharomyces cerevisiae)
>gi|1008332|emb|CAA89425.1| (Z49405) ORF YJL130c
[Saccharomyces cerevisiae]
Length = 2214
Score = 294 bits (746), Expect = 6e-79
Identities = 148/306 (48%), Positives = 210/306 (68%), Gaps = 2/306 (0%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++GR ++SI+ F + D + A A+ L + +G L+ KG ++ T+FFEPSTRT SF
Sbjct: 1908 FRGRHILSIKQFKRSDFHVLFAVAQELRAAVAREGVLDLMKGHVITTIFFEPSTRTCSSF 1967
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
+AM RLGG ++ SSVKKGE+L+DTI+T+ Y D IV+RH +E + +AA+ +
Sbjct: 1968 IAAMERLGGRIVN-VNPLVSSVKKGETLQDTIRTLACYSDAIVMRHSEEMSVHIAAKYSP 2026
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VP+IN G+GS +HPTQ LDL+TI++E G ++G+ + +GDLK+GRTVHSL L Y V
Sbjct: 2027 VPIINGGNGSREHPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQV 2086
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFPDEQEY 241
+ L+SP LR+P + EELR+ G+ VE+ L +I K DVLY TR+Q+ERF +EY
Sbjct: 2087 RINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEY 2146
Query: 242 LKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
++K +Y V+ K+L AK+ + IMHPLPRV+EI EVD A YFRQ+ G+ VRMALL
Sbjct: 2147 ARLKDTYIVDNKILAHAKENMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMALL 2206
Query: 302 ALVLGV 307
A+V+GV
Sbjct: 2207 AMVMGV 2212
>gb|AAF01338.1|AF190426_2 (AF190426) aspartate transcarbamylase catalytic subunit [Erwinia
herbicola]
Length = 311
Score = 293 bits (743), Expect = 1e-78
Identities = 152/303 (50%), Positives = 212/303 (69%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S+E++E L TA +L K Q E K K++A+ FFE STRTRLSFE+A
Sbjct: 8 KHIISINDLSREELELALHTAAKL----KAHPQPELLKHKVIASCFFEASTRTRLSFETA 63
Query: 66 MHRLGGAVIGFAEASTSSV-KKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE-V 123
+HRLG + +GFA+ S +S+ KKGE+L DTI + Y D IV+RHP+EGAARLA E + +
Sbjct: 64 IHRLGASAVGFADGSNTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGGI 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-V 182
P++NAGDG+NQHPTQTLLDL+TI++ R++ L + ++GDLKYGRTVHSL +AL +D
Sbjct: 124 PILNAGDGANQHPTQTLLDLFTIQETQSRLNQLNVAMVGDLKYGRTVHSLTQALAKFDGN 183
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
+ I+P+ L MP +I + L EK + + E+V+ +LD+LY+TR+QKER D EY
Sbjct: 184 RFFFIAPDALAMPAYITDMLDEKNISWSRHDSFEEVMPQLDILYMTRVQKERL-DPSEYA 242
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + L A+D ++++HPLPR+DEI +VD T +A YF+Q NG+ R ALLA
Sbjct: 243 NVKAQFILRAADLATARDNMKVLHPLPRIDEITTDVDKTPYAWYFQQAGNGIYARQALLA 302
Query: 303 LVL 305
LVL
Sbjct: 303 LVL 305
>pir||OWEBAC aspartate carbamoyltransferase (EC 2.1.3.2) catalytic chain -
Salmonella typhimurium >gi|47863|emb|CAA29129.1|
(X05641) pyrB (AA 1-311) [Salmonella typhimurium]
Length = 311
Score = 293 bits (741), Expect = 2e-78
Identities = 160/305 (52%), Positives = 215/305 (70%), Gaps = 12/305 (3%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 8 KHIISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 63
Query: 66 MHRLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GF++ A+TS KKGE+L DTI + Y D IV+RHP+EGAARLA E + +V
Sbjct: 64 MHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGQV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT---FY 180
PV+NAGDGSNQHPTQTLLDL+TI++ GR+D L I ++GDLKYGRTVH A+ T F
Sbjct: 124 PVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHIAMVGDLKYGRTVH-FAKPRTLAKFS 182
Query: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE 240
Y I+P+ L MP++I++ L EKGM ++E+V+ +D+LY+TR+QKER D E
Sbjct: 183 GNRFYFIAPDALAMPQYILDMLDEKGMAWSLHGSIEEVMADVDILYMTRVQKERL-DPSE 241
Query: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
Y VK + V L A++ ++++HPLPR+DEI +VD T HA YF+Q NG+ AL
Sbjct: 242 YANVKAQF-VLRPDLNGARENMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFAAQAL 300
Query: 301 LALVL 305
LALVL
Sbjct: 301 LALVL 305
>sp|Q09794|PYR1_SCHPO URA1 PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ]
>gi|2130327|pir||S62450 hypothetical protein SPAC22G7.06c
- fission yeast (Schizosaccharomyces pombe)
>gi|7436765|pir||T11616 carbamoyl-phosphate synthase
(glutamine-hydrolyzing) (EC 6.3.5.5) - fission yeast
(Schizosaccharomyces pombe) >gi|1009456|emb|CAA91130.1|
(Z54328) ura1 protein contains: glutamine-dependent
carbamoyl-phosphatesynthase [Schizosaccharomyces pombe]
Length = 2244
Score = 289 bits (732), Expect = 3e-77
Identities = 149/303 (49%), Positives = 207/303 (68%), Gaps = 3/303 (0%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +IS+ ++ D+ + A A ++ ++ +G ++ GK+L T+FFEPSTRT SF++A
Sbjct: 1937 KHIISVHQVTRSDLHVLFAIAHQMRIIVERQGVIDLCYGKLLCTMFFEPSTRTSSSFDAA 1996
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
M RLGG V+ AS SSV KGESL DTI+T+ Y D IV+RHP +AR+AA + VP+
Sbjct: 1997 MQRLGGKVVAVT-ASASSVNKGESLADTIRTLGCYGDAIVLRHPSIESARIAANFSPVPI 2055
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELY 185
IN G+GS +HPTQ LDLYTI++E G ++GL I +GDLKYGRTVHSLA L F+ VEL+
Sbjct: 2056 INGGNGSKEHPTQAFLDLYTIREELGSVNGLTITFIGDLKYGRTVHSLARLLAFWHVELH 2115
Query: 186 LISPELLRMPRHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
L+SPE L +P + +++R G+ +E L ++V+ + DVLY TR+QKERF EY K+
Sbjct: 2116 LVSPEQLALPDDVKDDIRANGLNFIEHRELTKEVVAQSDVLYCTRVQKERFASVDEYEKL 2175
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVD-NTKHAIYFRQVFNGVPVRMALLAL 303
K S+ V+ VL AK +MHPLPR EI EVD + + A YFRQ+ G+ +RMALLA
Sbjct: 2176 KDSFIVDNSVLASAKSHCIVMHPLPRNREISEEVDFDQRRAAYFRQMRYGLYIRMALLAC 2235
Query: 304 VLG 306
V+G
Sbjct: 2236 VMG 2238
>sp|P08955|PYR1_MESAU CAD PROTEIN [INCLUDES: GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE
SYNTHASE ; ASPARTATE CARBAMOYLTRANSFERASE ;
DIHYDROOROTASE ] >gi|538556|pir||A23443 pyrimidine
synthesis multifunctional protein CAD - golden hamster
Length = 2225
Score = 289 bits (732), Expect = 3e-77
Identities = 145/302 (48%), Positives = 211/302 (69%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++S++ F+K+ + + A L ++++ L+ KGK++A++F+E STRT SF +
Sbjct: 1923 GQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAA 1982
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGGAV+ F+EA TSSV+KGESL D+++T+ Y DV+V+RHP+ GA LAA+ P
Sbjct: 1983 AMARLGGAVLSFSEA-TSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP 2041
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VINAGDG +HPTQ LLD++TI++E G ++G+ I ++GDLK+GRTVHSLA LT Y V L
Sbjct: 2042 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL 2101
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
++P LRMP + + + +G K E ++E+ + DVLY+TRIQKERF QEY
Sbjct: 2102 RYVAPPSLRMPPSVWDFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC 2161
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
G + + ++ +AK ++ +MHP+PRV+EI EVD+ A YFRQ NG+ +RMALLA V
Sbjct: 2162 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV 2221
Query: 305 LG 306
LG
Sbjct: 2222 LG 2223
>gb|AAA37064.1| (M23652) CAD protein [Mesocricetus auratus]
Length = 452
Score = 289 bits (732), Expect = 3e-77
Identities = 145/302 (48%), Positives = 211/302 (69%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++S++ F+K+ + + A L ++++ L+ KGK++A++F+E STRT SF +
Sbjct: 150 GQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAA 209
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGGAV+ F+EA TSSV+KGESL D+++T+ Y DV+V+RHP+ GA LAA+ P
Sbjct: 210 AMARLGGAVLSFSEA-TSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP 268
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VINAGDG +HPTQ LLD++TI++E G ++G+ I ++GDLK+GRTVHSLA LT Y V L
Sbjct: 269 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL 328
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
++P LRMP + + + +G K E ++E+ + DVLY+TRIQKERF QEY
Sbjct: 329 RYVAPPSLRMPPSVWDFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC 388
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
G + + ++ +AK ++ +MHP+PRV+EI EVD+ A YFRQ NG+ +RMALLA V
Sbjct: 389 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV 448
Query: 305 LG 306
LG
Sbjct: 449 LG 450
>sp|Q43086|PYB1_PEA ASPARTATE CARBAMOYLTRANSFERASE 1 PRECURSOR (ASPARTATE
TRANSCARBAMYLASE 1) (ATCASE 1) >gi|7433585|pir||T06484
aspartate carbamoyltransferase (EC 2.1.3.2) - garden pea
>gi|495659|gb|AAA62443.1| (M96981) aspartate
carbamoyltransferase [Pisum sativum]
Length = 386
Score = 287 bits (727), Expect = 1e-76
Identities = 153/302 (50%), Positives = 204/302 (66%), Gaps = 3/302 (0%)
Query: 7 DVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAM 66
DVI + F +E + + A +E + KG ++ATLF+EPSTRTRLSFESAM
Sbjct: 82 DVIEAQQFDRETLSAIFEVARSMENIRGNSSGSQMLKGYLMATLFYEPSTRTRLSFESAM 141
Query: 67 HRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
RLGG V+ A SS KGE+L DTI+TVE Y D+IV+RH + GAAR AA A +PV
Sbjct: 142 KRLGGDVLTTENAREFSSAAKGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATANIPV 201
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY-DVEL 184
INAGDG QHP+Q LLD+YTI++E G++DG+K+GL+GDL GRTV SLA L Y DV+L
Sbjct: 202 INAGDGPGQHPSQALLDVYTIEREIGKLDGIKVGLVGDLANGRTVRSLAYLLAKYRDVKL 261
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE-YLK 243
Y +SP +++M I E L KG++ E++ L +V K DV+Y TRIQKERF ++ Y +
Sbjct: 262 YFVSPNVVKMKDDIKEYLTSKGVEWEESSDLMEVASKCDVVYQTRIQKERFGEKLNLYEE 321
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
+G Y VN VL+ ++ +MHPLP++DEI +VDN A YFRQ NG+ +RMALL +
Sbjct: 322 ARGKYIVNQDVLKVMQNHAVVMHPLPKLDEIEADVDNDPRAAYFRQAKNGLYIRMALLKV 381
Query: 304 VL 305
+L
Sbjct: 382 LL 383
>pir||A36240 pyrimidine synthesis protein CAD - human (fragment)
>gi|179770|gb|AAA51907.1| (M38561) CAD [Homo sapiens]
Length = 474
Score = 287 bits (727), Expect = 1e-76
Identities = 145/302 (48%), Positives = 210/302 (69%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++S++ F+K+ + + A L ++++ L+ KGK++A++F+E STRT SF +
Sbjct: 172 GQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAA 231
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGGAV+ F+EA TSSV+KGESL D+++T+ Y DV+V+RHP+ GA LAA+ P
Sbjct: 232 AMARLGGAVLSFSEA-TSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP 290
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VINAGDG +HPTQ LLD++TI++E G ++G+ I ++GDLK+GRTVHSLA LT Y V L
Sbjct: 291 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL 350
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
++P LRMP + + +G K E ++E+ + DVLY+TRIQKERF QEY
Sbjct: 351 RYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC 410
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
G + + ++ +AK ++ +MHP+PRV+EI EVD+ A YFRQ NG+ +RMALLA V
Sbjct: 411 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV 470
Query: 305 LG 306
LG
Sbjct: 471 LG 472
>gi|4757896 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and
dihydroorotase; CAD trifunctional protein of pyrimidine
biosynthesis [Homo sapiens]
>gi|1709955|sp|P27708|PYR1_HUMAN CAD PROTEIN [INCLUDES:
GLUTAMINE-DEPENDENT CARBAMOYL-PHOSPHATE SYNTHASE ;
ASPARTATE CARBAMOYLTRANSFERASE ; DIHYDROOROTASE ]
>gi|1228049|dbj|BAA11423.1| (D78586) multifunctional
protein CAD [Homo sapiens]
Length = 2225
Score = 287 bits (727), Expect = 1e-76
Identities = 145/302 (48%), Positives = 210/302 (69%), Gaps = 1/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++S++ F+K+ + + A L ++++ L+ KGK++A++F+E STRT SF +
Sbjct: 1923 GQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAA 1982
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGGAV+ F+EA TSSV+KGESL D+++T+ Y DV+V+RHP+ GA LAA+ P
Sbjct: 1983 AMARLGGAVLSFSEA-TSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP 2041
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VINAGDG +HPTQ LLD++TI++E G ++G+ I ++GDLK+GRTVHSLA LT Y V L
Sbjct: 2042 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL 2101
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
++P LRMP + + +G K E ++E+ + DVLY+TRIQKERF QEY
Sbjct: 2102 RYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC 2161
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
G + + ++ +AK ++ +MHP+PRV+EI EVD+ A YFRQ NG+ +RMALLA V
Sbjct: 2162 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV 2221
Query: 305 LG 306
LG
Sbjct: 2222 LG 2223
>sp|Q55338|PYRB_SULAC ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|1486468|emb|CAA68165.1| (X99872) aspartate
carbamoyltransferase [Sulfolobus acidocaldarius]
Length = 299
Score = 286 bits (725), Expect = 2e-76
Identities = 150/302 (49%), Positives = 207/302 (67%), Gaps = 6/302 (1%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +IS +FS++++E + A ++ + L + ++ GK ++ FFEPSTRT LSF+ A
Sbjct: 2 KHIISAYNFSRDELEDIFALTDKYSKNLNDTRKI--LSGKTISIAFFEPSTRTYLSFQKA 59
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
+ LGG VIGF+ ++SV KGE+L DTI+ + Y D IV+RH +GA+R A+E++++PV
Sbjct: 60 IINLGGDVIGFSGEESTSVAKGENLADTIRMLNNYSDGIVMRHKYDGASRFASEISDIPV 119
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL- 184
INAGDG ++HPTQ ++D+YTI K F IDGL LLGDLKY RTV+SL LT + +L
Sbjct: 120 INAGDGKHEHPTQAVIDIYTINKHFNTIDGLVFALLGDLKYARTVNSLLRILTRFRPKLV 179
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
YLISP+LLR + I++EL V E +VI ++DVLYVTRIQKERF DE EY K+
Sbjct: 180 YLISPQLLRARKEILDEL---NYPVKEVENPFEVINEVDVLYVTRIQKERFVDEMEYEKI 236
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
KGSY V+L + K K + I+HPLPRV+EI +VD T A YF Q GVPVRM++L +
Sbjct: 237 KGSYIVSLDLANKMKKDSIILHPLPRVNEIDRKVDKTTKAKYFEQASYGVPVRMSILTKI 296
Query: 305 LG 306
G
Sbjct: 297 YG 298
>sp|P19910|PYRB_SERMA ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (ASPARTATE
TRANSCARBAMYLASE) (ATCASE) >gi|279484|pir||OWSEAC
aspartate carbamoyltransferase (EC 2.1.3.2) catalytic
chain - Serratia marcescens >gi|398075|gb|AAA26564.1|
(J05033) aspartate transcarbamoylase [Serratia
marcescens]
Length = 306
Score = 284 bits (720), Expect = 7e-76
Identities = 155/302 (51%), Positives = 211/302 (69%), Gaps = 12/302 (3%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +ISI D S++D+E VLATA L K Q E K K++A+ FFE STRTRLSFE++
Sbjct: 8 KHIISINDLSRDDLELVLATAAGL----KANPQPELLKHKVIASCFFEASTRTRLSFETS 63
Query: 66 MHRLGGAVIGFAEASTSSV-KKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
MHRLG +V+GFA+ S +S+ KKGE+L DTI + Y D IV+RHP+EGA R+A+E + V
Sbjct: 64 MHRLGASVVGFADGSNTSLGKKGETLADTISVISTYVDAIVMRHPQEGA-RMASEFSGNV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDV 182
PV+NAGDG NQHPTQTLLDL+TI++ GR+ L I ++GDLKYGRTVHSL +AL F
Sbjct: 123 PVLNAGDG-NQHPTQTLLDLFTIQETQGRLSNLSIAMVGDLKYGRTVHSLTQALAKFEGN 181
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
Y I+P+ L MP +I++ L EKG++ ++E+V+ +LD+LY+TR+QKER D EY
Sbjct: 182 RFYFIAPDALAMPAYILKMLEEKGIEYSSHGSIEEVVPELDILYMTRVQKERL-DPSEYA 240
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
VK + + + A L+++HPLPR+DEI +VD T HA YF+Q NG+ R AL
Sbjct: 241 NVKAQFVLAADLAGAA--NLKVLHPLPRIDEIATDVDKTPHAYYFQQAGNGIFARSALAL 298
Query: 303 LV 304
+V
Sbjct: 299 VV 300
>pir||S65074 pyrimidine synthesis protein URA1 - fission yeast
(Schizosaccharomyces pombe) >gi|1154952|emb|CAA57433.1|
(X81841) carbamoyl-phosphate synthase
(glutamine-hydrolysing) [Schizosaccharomyces pombe]
Length = 2223
Score = 283 bits (716), Expect = 2e-75
Identities = 147/303 (48%), Positives = 205/303 (67%), Gaps = 3/303 (0%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ +IS+ ++ D+ + A A ++ ++ +G ++ K+L T+FFEPSTRT SF++A
Sbjct: 1916 KHIISVHQVTRSDLHVLFAIAHQMRIIVERQGVIDLCYEKLLCTMFFEPSTRTSSSFDAA 1975
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
M RLG V+ AS SSV KGESL DTI+T+ Y D IV+RHP +AR+AA + VP+
Sbjct: 1976 MQRLGEKVVAVT-ASASSVNKGESLADTIRTLGCYGDAIVLRHPSIESARIAANFSPVPI 2034
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELY 185
IN G+GS +HPTQ LDLYTI++E G ++GL I +GDLKYGRTVHSLA L F+ VEL+
Sbjct: 2035 INGGNGSKEHPTQAFLDLYTIREELGSVNGLTITFIGDLKYGRTVHSLARLLAFWHVELH 2094
Query: 186 LISPELLRMPRHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
L+SPE L +P + +++R G+ +E L ++V+ + DVLY TR+QKERF EY K+
Sbjct: 2095 LVSPEQLALPDDVKDDIRANGLNFIEHRELTKEVVAQSDVLYCTRVQKERFASVDEYEKL 2154
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVD-NTKHAIYFRQVFNGVPVRMALLAL 303
K S+ V+ VL AK +MHPLPR EI EVD + + A YFRQ+ G+ +RMALLA
Sbjct: 2155 KDSFIVDNSVLASAKSHCIVMHPLPRNREISEEVDFDQRRAAYFRQMRYGLYIRMALLAC 2214
Query: 304 VLG 306
V+G
Sbjct: 2215 VMG 2217
>pdb|2ATC|A Chain A, Aspartate Carbamoyltransferase (Aspartate
Transcarbamylase) (E.C.2.1.3.2)
Length = 305
Score = 282 bits (715), Expect = 3e-75
Identities = 157/304 (51%), Positives = 211/304 (68%), Gaps = 19/304 (6%)
Query: 8 VISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMH 67
+ISI D S++D+ VLATA +L K Q E K K++A+ FFE STRTRLSF+++MH
Sbjct: 9 IISINDLSRDDLNLVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFQTSMH 64
Query: 68 RLGGAVIGFAE-ASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EVPV 125
RLG +V+GF++ A+TS KKG++L +TI + Y D IV+RHP+EGAARLA E + VPV
Sbjct: 65 RLGASVVGFSDSANTSLGKKGQTLANTISVISTYVDAIVMRHPQEGAARLATEFSGNVPV 124
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD-VEL 184
+NAGDGSNQHPTQTLLDL+TI++ GR++ L + ++GDLKYGRTVHSL +AL +D
Sbjct: 125 LNAGDGSNQHPTQTLLDLFTIQQTEGRLNNLHVAMVGDLKYGRTVHSLTQALAKFDGNRF 184
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
Y I+P+ L MP +I++ L EKG+ +++E+V +TR+QKER D EY V
Sbjct: 185 YFIAPDALAMPEYILDMLDEKGIAWSLHSSIEEV--------MTRVQKERL-DPSEYAXV 235
Query: 245 KGSYQV---NLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
K + V +L L AK +++HPLPRVDEI +VD T HA YF+Q NG+ R ALL
Sbjct: 236 KAQFLVRANSLGGLHNAKMNAKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALL 295
Query: 302 ALVL 305
ALVL
Sbjct: 296 ALVL 299
>sp|P57450|PYRB_BUCAI ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (ASPARTATE
TRANSCARBAMYLASE) (ATCASE) >gi|10039039|dbj|BAB13073.1|
(AP001119) aspartate carbamoyltransferase catalytic
chain [Buchnera sp. APS]
Length = 310
Score = 281 bits (712), Expect = 6e-75
Identities = 144/303 (47%), Positives = 210/303 (68%), Gaps = 8/303 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+++ISI D + ++E VL + L K+ Q K K++A+ FFE STRTRLSFE+A
Sbjct: 8 KNIISINDLQRNELELVLNKSAML----KKTPQPNLLKNKVIASCFFEASTRTRLSFETA 63
Query: 66 MHRLGGAVIGFAEASTSSV-KKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA-EV 123
++RLG +++GF++ + S+ KKGE+L DTI + Y D I+IRHP+EG+ARLAAE + +
Sbjct: 64 IYRLGASIVGFSDGNNISLEKKGETLTDTISVISSYVDAIIIRHPQEGSARLAAEFSNKK 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDV 182
P+ NAGDG+NQHPTQTLLDL+TI++ R+ L I ++GDLKYGRTVHSL +AL F
Sbjct: 124 PIFNAGDGANQHPTQTLLDLFTIQETQNRLTQLNIAIVGDLKYGRTVHSLTQALAKFKHN 183
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
+ Y ISP+ L+MP +I L +K + +E++I ++D+LY+TRIQKER D EY
Sbjct: 184 KFYFISPDALKMPNYINNMLDKKEIYWKRHNNIEEIISEIDILYMTRIQKERL-DSTEYA 242
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
K + + +L+ A++ ++I+HPLPR+DEI +VD T +A YF+Q NG+ R A+L+
Sbjct: 243 NAKSKFVLRAAILKNARNNMKILHPLPRIDEIDRDVDYTPYAWYFKQAANGIYARQAILS 302
Query: 303 LVL 305
LVL
Sbjct: 303 LVL 305
>dbj|BAB02813.1| (AB024036) aspartate carbamoyltransferase [Arabidopsis thaliana]
Length = 390
Score = 279 bits (705), Expect = 4e-74
Identities = 151/302 (50%), Positives = 201/302 (66%), Gaps = 3/302 (0%)
Query: 7 DVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAM 66
DVI + F +E + + A +E+ K Q E KG ++ATLF+EPSTRTRLSFESAM
Sbjct: 86 DVIEGKQFDREMLSAIFDVAREMEKIEKSSSQSEILKGYLMATLFYEPSTRTRLSFESAM 145
Query: 67 HRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
RLGG V+ A SS KGE+L DTI+TVE Y D+IV+RH + GAAR AA A +PV
Sbjct: 146 KRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDIIVMRHFESGAARKAAATANIPV 205
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDVEL 184
INAGDG +HPTQ LLD+YTI+ E G++DG+ + L+GDL GRTV SLA L F DV++
Sbjct: 206 INAGDGPGEHPTQALLDVYTIQSEIGKLDGISVALVGDLANGRTVRSLAYLLAKFKDVKI 265
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE-YLK 243
Y +SPE+++M I + L G++ E++ L +V K DV+Y TRIQ+ERF + + Y
Sbjct: 266 YFVSPEIVKMKDDIKDYLTSSGVEWEESSDLMEVASKCDVVYQTRIQRERFGERLDLYEA 325
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
+G Y V+ +L + + IMHPLPR+DEI +VD A YFRQ NG+ +RMALL L
Sbjct: 326 ARGKYIVDKDLLGVMQKKAIIMHPLPRLDEITADVDADPRAAYFRQAKNGLFIRMALLKL 385
Query: 304 VL 305
+L
Sbjct: 386 LL 387
>sp|Q43064|PYB3_PEA ASPARTATE CARBAMOYLTRANSFERASE 3 PRECURSOR (ASPARTATE
TRANSCARBAMYLASE 3) (ATCASE 3) >gi|7433584|pir||T06425
aspartate carbamoyltransferase (EC 2.1.3.2) - garden pea
>gi|609344|gb|AAB67857.1| (U05293) aspartate
carbamoyltransferase [Pisum sativum]
Length = 391
Score = 278 bits (704), Expect = 5e-74
Identities = 148/302 (49%), Positives = 203/302 (67%), Gaps = 3/302 (0%)
Query: 7 DVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAM 66
DVI + F ++ + + A +E + + + KG ++ATLF+EPSTRTRLSFESAM
Sbjct: 87 DVIEAQQFDRDILNAIFEIARDMENIERNSPESQILKGYLMATLFYEPSTRTRLSFESAM 146
Query: 67 HRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
RLGG V+ A SS KGE+L DTI+TVE Y D+IV+RH + GAAR AA +A +P+
Sbjct: 147 RRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDLIVLRHFESGAARRAAAIAGIPI 206
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY-DVEL 184
+NAGDG QHP+Q LLD+YTI++E G++DG+K+GL+GDL GRTV SLA L Y DV++
Sbjct: 207 VNAGDGPGQHPSQALLDVYTIEREIGKLDGIKVGLVGDLANGRTVRSLAYLLAKYKDVKI 266
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE-YLK 243
Y +SPE+++M I + L KG+ E++ L +V + DV+Y TRIQKERF + + Y K
Sbjct: 267 YFVSPEVVKMKDDIKDYLTSKGVDWEESSDLVEVASECDVVYQTRIQKERFGERLDLYEK 326
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
+G + VN +L + IMHPLPR+DEI +VD A YFRQ G+ +RMALL L
Sbjct: 327 ARGKFIVNQNILNAMQRHAVIMHPLPRLDEITVDVDADPRAAYFRQAKYGLYIRMALLKL 386
Query: 304 VL 305
+L
Sbjct: 387 LL 388
>gb|AAA35198.1| (J04711) carbamylase phosphate synthetase-aspartate
transcarbamylase (EC 2.1.3.2) [Saccharomyces cerevisiae]
Length = 947
Score = 277 bits (702), Expect = 9e-74
Identities = 143/307 (46%), Positives = 205/307 (66%), Gaps = 3/307 (0%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++GR ++SI+ F + D + A A+ L + +G L+ KG ++ T+FFEPSTRT SF
Sbjct: 640 FRGRHILSIKQFKRSDFHVLFAVAQELRARVAREGVLDLMKGHVITTIFFEPSTRTCSSF 699
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
+AM RLGG ++ SSVKKGE+L+D I+T+ Y D IV+RH +E + +AA+ +
Sbjct: 700 IAAMERLGGRIVN-VNPLVSSVKKGETLQDIIRTLACYSDAIVMRHSEEMSVHIAAKYSP 758
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VP+IN G+GS + PTQ LDL+TI++E G ++G+ + +GDLK+GRTVHSL L Y V
Sbjct: 759 VPIINGGNGSRELPTQAFLDLFTIREEIGTVNGITVTFMGDLKHGRTVHSLCRLLMHYQV 818
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFPDEQEY 241
+ L+SP LR+P + EELR+ G+ VE+ L +I K DVLY TR+Q+ERF +EY
Sbjct: 819 RINLVSPPELRLPEGLREELRKAGLLGVESIELTPHIISKTDVLYCTRVQEERFNSPEEY 878
Query: 242 LKVKGSYQV-NLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
++K +Y V N++ + + IMHPLPRV+EI EVD A YFRQ+ G+ VRMAL
Sbjct: 879 ARLKDTYIVDNVRSWHTQQKNMAIMHPLPRVNEIKEEVDYDHRAAYFRQMKYGLFVRMAL 938
Query: 301 LALVLGV 307
LA+V+GV
Sbjct: 939 LAMVMGV 945
>sp|Q43087|PYB2_PEA ASPARTATE CARBAMOYLTRANSFERASE 2 PRECURSOR (ASPARTATE
TRANSCARBAMYLASE 2) (ATCASE 2) >gi|7433605|pir||T10181
aspartate carbamoyltransferase (EC 2.1.3.2) - garden pea
>gi|495661|gb|AAA62444.1| (L15798) aspartate
transcarbamoylase [Pisum sativum]
Length = 385
Score = 277 bits (702), Expect = 9e-74
Identities = 146/302 (48%), Positives = 203/302 (66%), Gaps = 3/302 (0%)
Query: 7 DVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAM 66
DV+ + F ++ + + A +E+ + + + KG ++ATLF+EPSTRTRLSFESAM
Sbjct: 81 DVVEAQQFDRDILNAIFEVARDMEKIERNSPESQILKGYLMATLFYEPSTRTRLSFESAM 140
Query: 67 HRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
RLGG V+ A SS KGE+L DTI+TVE Y D+IV+RH + GAAR AA +A +P+
Sbjct: 141 RRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDLIVLRHFESGAARRAATIAGIPI 200
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY-DVEL 184
+NAGDG QHP+Q LLD+YTI++E G++DG+K+GL+GDL GRTV SL L Y DV++
Sbjct: 201 VNAGDGPGQHPSQALLDVYTIEREIGKLDGIKVGLVGDLANGRTVRSLTYLLAKYKDVKI 260
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE-YLK 243
Y +SPE+++M I + L KG+ E++ L +V + DV+Y TRIQKERF + + Y K
Sbjct: 261 YFVSPEVVKMKDDIKDYLTSKGVDWEESSDLVEVASECDVVYQTRIQKERFGERLDLYEK 320
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
+G + VN +L + IMHPLPR+DEI +VD A YFRQ G+ +RMALL L
Sbjct: 321 ARGKFIVNQNILNAMQRHAVIMHPLPRLDEITVDVDADPRAAYFRQAKYGLYIRMALLKL 380
Query: 304 VL 305
+L
Sbjct: 381 LL 382
>sp|P49077|PYRB_ARATH ASPARTATE CARBAMOYLTRANSFERASE PRECURSOR (ASPARTATE
TRANSCARBAMYLASE) (ATCASE) >gi|1076293|pir||S46441
aspartate carbamoyltransferase (EC 2.1.3.2) -
Arabidopsis thaliana >gi|443820|emb|CAA50687.1| (X71843)
aspartate carbamoyltransferase [Arabidopsis thaliana]
Length = 390
Score = 277 bits (701), Expect = 1e-73
Identities = 150/302 (49%), Positives = 201/302 (65%), Gaps = 3/302 (0%)
Query: 7 DVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAM 66
DVI + F +E + + A +E+ K Q E KG ++ATLF+EPSTRTRLSFESAM
Sbjct: 86 DVIEGKQFDREMLSAIFDVAREMEKIEKSSSQSEILKGYLMATLFYEPSTRTRLSFESAM 145
Query: 67 HRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
RLGG V+ A SS KGE+L DTI+TVE Y D+IV+RH + GAAR AA A +PV
Sbjct: 146 KRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDIIVMRHFESGAARKAAATANIPV 205
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDVEL 184
INAGDG +HPTQ LLD+YTI+ E G++DG+ + L+GDL GRTV SLA L F DV++
Sbjct: 206 INAGDGPGEHPTQALLDVYTIQSEIGKLDGISVALVGDLANGRTVRSLAYLLAKFKDVKI 265
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE-YLK 243
Y +SPE+++M I + L G++ E++ L +V K DV+Y TRIQ+ERF + + Y
Sbjct: 266 YFVSPEIVKMKDDIKDYLTSSGVEWEESSDLMEVASKCDVVYQTRIQRERFGERLDLYEA 325
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
+G + V+ +L + + IMHPLPR+DEI +VD A YFRQ NG+ +RMALL L
Sbjct: 326 ARGKFIVDKDLLGVMQKKAIIMHPLPRLDEITADVDADPRAAYFRQAKNGLFIRMALLKL 385
Query: 304 VL 305
+L
Sbjct: 386 LL 387
>gb|AAK40925.1| Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB)
[Sulfolobus solfataricus]
Length = 303
Score = 275 bits (696), Expect = 4e-73
Identities = 151/302 (50%), Positives = 200/302 (66%), Gaps = 8/302 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
R V+S D +++D + A++ K L Y GK+++ FFEPSTRT SF +A
Sbjct: 4 RHVVSSLDLTRDDYFRIFELADKFYDVKK----LNYLSGKVVSLAFFEPSTRTAQSFHTA 59
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
+LG VIGFA ++S+ KGE+L DTI+ + Y + IV+RH +GAA A+E++++P+
Sbjct: 60 AIKLGADVIGFASEESTSIAKGENLADTIRMLNNYSNCIVMRHKFDGAALFASEISDIPI 119
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDVEL 184
INAGDG ++HPTQ ++DLYT+ K FG IDG LLGDLKY RTV+SL ALT F ++
Sbjct: 120 INAGDGKHEHPTQAVIDLYTVYKAFGEIDGRTFALLGDLKYARTVNSLLRALTRFKPKKV 179
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
+LISP L++ R I++EL V+ET DVI ++DVLYVTRIQKERF DE EY KV
Sbjct: 180 FLISPSQLKVRREILDEL---NYPVIETENPYDVIQEIDVLYVTRIQKERFVDEVEYEKV 236
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
K SY V+LK++ K + I+HPLPRV EI VD T +A YF Q VPVRMAL V
Sbjct: 237 KESYVVDLKLVNMMKKDGIILHPLPRVTEIDRRVDKTVNAKYFYQASLAVPVRMALFYEV 296
Query: 305 LG 306
LG
Sbjct: 297 LG 298
>sp|Q9UX08|PYRB_SULSO ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|6015859|emb|CAB57686.1| (Y18930) aspartate
carbamoyltransferase catalytic chain, (ATCASE)
[Sulfolobus solfataricus]
Length = 303
Score = 275 bits (696), Expect = 4e-73
Identities = 151/302 (50%), Positives = 200/302 (66%), Gaps = 8/302 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
R V+S D +++D + A++ K L Y GK+++ FFEPSTRT SF +A
Sbjct: 4 RHVVSSLDLTRDDYFRIFELADKFYDVKK----LNYLSGKVVSLAFFEPSTRTAQSFHTA 59
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
+LG VIGFA ++S+ KGE+L DTI+ + Y + IV+RH +GAA A+E++++P+
Sbjct: 60 AIKLGADVIGFASEESTSIAKGENLADTIRMLNNYSNCIVMRHKFDGAALFASEISDIPI 119
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT-FYDVEL 184
INAGDG ++HPTQ ++DLYT+ K FG IDG LLGDLKY RTV+SL ALT F ++
Sbjct: 120 INAGDGKHEHPTQAVIDLYTVYKAFGEIDGRTFALLGDLKYARTVNSLLRALTRFKPKKV 179
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
+LISP L++ R I++EL V+ET DVI ++DVLYVTRIQKERF DE EY KV
Sbjct: 180 FLISPSQLKVRREILDEL---NYPVIETENPYDVIQEIDVLYVTRIQKERFVDEVEYEKV 236
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
K SY V+LK++ K + I+HPLPRV EI VD T +A YF Q VPVRMAL V
Sbjct: 237 KESYVVDLKLVNMMKKDGIILHPLPRVTEIDRRVDKTVNAKYFYQASLAVPVRMALFYEV 296
Query: 305 LG 306
LG
Sbjct: 297 LG 298
>dbj|BAB03303.1| (AB037416) aspartate carbamoyl transferase [Oryza sativa]
>gi|9453918|dbj|BAB03304.1| (AB037417) aspartate
carbamoyl transferase [Oryza sativa]
Length = 363
Score = 274 bits (693), Expect = 1e-72
Identities = 151/307 (49%), Positives = 207/307 (67%), Gaps = 8/307 (2%)
Query: 7 DVISIRDFSKEDIETVLATA---ERLERELKEKG--QLEYAKGKILATLFFEPSTRTRLS 61
DVI + F ++ + + A E LER +G + +G ++ATLF+EPSTRTRLS
Sbjct: 54 DVIEAQQFDRDALTEIFEVAREMEALERGSSSRGAGRSRVLEGYLMATLFYEPSTRTRLS 113
Query: 62 FESAMHRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
FE+AM RLGG V+ A SS KGE+L DTI+TVE Y D+IV+RH + GAAR AA
Sbjct: 114 FEAAMRRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDIIVLRHFESGAARRAAAT 173
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY 180
A++PVINAGDG QHPTQ LLD+Y+I++E G +DG+K+GL+GDL GRTV SLA + Y
Sbjct: 174 ADIPVINAGDGPGQHPTQALLDVYSIEREIGTLDGIKLGLVGDLANGRTVRSLAYLIAKY 233
Query: 181 -DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQ 239
++++Y +SP++++M I E L +G++ E++ L +V K DV+Y TRIQKERF +
Sbjct: 234 QNIKIYFVSPDVVKMKDDIKEYLTSQGVEWEESSDLLEVASKCDVIYQTRIQKERFGERI 293
Query: 240 E-YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRM 298
+ Y +G Y V+ KVL+ IMHPLPR+DEI +VD+ A YFRQ NG+ +RM
Sbjct: 294 DLYEAARGKYIVDKKVLDVLPKHAVIMHPLPRLDEITIDVDSDPRAAYFRQAKNGLYIRM 353
Query: 299 ALLALVL 305
ALL L+L
Sbjct: 354 ALLKLLL 360
>gb|AAF48639.2| (AE003503) CG18572 gene product [Drosophila melanogaster]
Length = 2188
Score = 272 bits (687), Expect = 5e-72
Identities = 140/303 (46%), Positives = 207/303 (68%), Gaps = 2/303 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLE-RELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
G+ ++++ F+K+ + + A+ L+ R K++ E GKI+A++F+E STRT+ SF
Sbjct: 1881 GKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVDELLPGKIMASVFYEVSTRTQCSFA 1940
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+AM RLGG VI + TSSVKKGESL D+IK V Y DV+V+RHP GA AA +
Sbjct: 1941 AAMLRLGGRVISM-DNITSSVKKGESLEDSIKVVSSYADVVVLRHPSPGAVARAATFSRK 1999
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
P+INAGDG +HPTQ LLD++TI++EFG ++GL I ++GDLK GRTVHSLA LT Y+V
Sbjct: 2000 PLINAGDGVGEHPTQALLDIFTIREEFGTVNGLTITMVGDLKNGRTVHSLARLLTLYNVN 2059
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLK 243
L ++P L+MP +V+ + ++G+K + L++V+ DVLY+TRIQ+ERF + ++Y K
Sbjct: 2060 LQYVAPNSLQMPDEVVQFVHQRGVKQLFARDLKNVLPDTDVLYMTRIQRERFDNVEDYEK 2119
Query: 244 VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLAL 303
G + + + +AK ++HPLPR++EI E+D+ A YFRQ G+ +RMALLA+
Sbjct: 2120 CCGHLVLTPEHMMRAKKRSIVLHPLPRLNEISREIDSDPRAAYFRQAEYGMYIRMALLAM 2179
Query: 304 VLG 306
V+G
Sbjct: 2180 VVG 2182
>pir||S35212 aspartate carbamoyltransferase (EC 2.1.3.2) - tomato (fragment)
Length = 268
Score = 266 bits (672), Expect = 3e-70
Identities = 139/265 (52%), Positives = 185/265 (69%), Gaps = 3/265 (1%)
Query: 44 GKILATLFFEPSTRTRLSFESAMHRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCD 102
G ++ATLF+EPSTRTRLSFES+M RLGG V+ A SS KGE+L DTI+TVE Y D
Sbjct: 1 GYLMATLFYEPSTRTRLSFESSMKRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSD 60
Query: 103 VIVIRHPKEGAARLAAEVAEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLG 162
+IV+RH + GAAR AA A +P+INAGDG QHPTQ LLD+YTI +E G++DG+ I L+G
Sbjct: 61 IIVMRHFESGAARRAALTASIPIINAGDGPGQHPTQALLDVYTIGREIGKLDGINIALVG 120
Query: 163 DLKYGRTVHSLAEALTFY-DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGK 221
DL YGRTV SLA L Y DV++Y +SP++++M I + L G++ E+ L +V K
Sbjct: 121 DLAYGRTVRSLAHLLALYKDVKIYFVSPDVVKMKDDIKDYLTSMGVRWEESADLIEVASK 180
Query: 222 LDVLYVTRIQKERFPDEQE-YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDN 280
DV+Y TRIQ+ERF + + Y + +G Y V++ V+ + +MHPLPR+DEI +VD
Sbjct: 181 CDVVYQTRIQRERFGERVDLYEEARGKYIVDMSVVNAMQKHAVVMHPLPRLDEITVDVDG 240
Query: 281 TKHAIYFRQVFNGVPVRMALLALVL 305
A YFRQ NG+ +RMALL L+L
Sbjct: 241 DPRAAYFRQAKNGLYIRMALLKLLL 265
>pir||T20371 hypothetical protein D2085.1 - Caenorhabditis elegans
>gi|3875382|emb|CAA91059.1| (Z54284) contains similarity
to Pfam domain: PF00117 (Glutamine amidotransferase
class-I), Score=244.1, E-value=6.1e-70, N=1; PF00185
(Aspartate/ornithine carbamoyltransferase), Score=397.5,
E-value=4.1e-116, N=1; PF00289 (Carbamoyl-phosphate
synthase >
Length = 2198
Score = 265 bits (670), Expect = 5e-70
Identities = 145/319 (45%), Positives = 210/319 (65%), Gaps = 19/319 (5%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYA-KGKILATLFFEPSTRTRLSFES 64
++ IS++ K I + A+R + ++++ L + GK+L LF+E STRT SF +
Sbjct: 1877 KNCISVKHLDKGQINRIFELADRYKHDVEKGHPLTHILNGKVLVNLFYEVSTRTSCSFSA 1936
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGG+VI ++ +SSV+KGE+L DT++ + Y D++V+R + GAA AA V + P
Sbjct: 1937 AMQRLGGSVIS-VDSQSSSVQKGETLEDTVQVLGSYGDILVLRSNENGAADRAARVCDQP 1995
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY-DVE 183
VIN GDG+ +HPTQ LLD+YTI++E G ++GL I L+GDLK GRTVHSLA+ L Y D+
Sbjct: 1996 VINGGDGTGEHPTQALLDVYTIRQEMGTVNGLTIALVGDLKNGRTVHSLAKLLCLYKDIT 2055
Query: 184 LYLISPEL-LRMPRHIVEELREKGMKVVET-TTLEDVIGKLDVLYVTRIQKERFPDEQEY 241
L+ ++P L MP+ +++ + K V + T+L + I +DV+YVTRIQKERF EY
Sbjct: 2056 LHYVAPSTELEMPQEVLDYVSSKSNFVQKKFTSLAEGINHVDVVYVTRIQKERFSSPDEY 2115
Query: 242 LKVKGSYQVNLKVLEKAKDELR--------------IMHPLPRVDEIHPEVDNTKHAIYF 287
KVKGSY +N K+L +A ++ +MHPLPRVDEI E+D+ + A YF
Sbjct: 2116 NKVKGSYVINAKLLNEAARDVEEPSSLLVPARSLPIVMHPLPRVDEIAVELDHDERAAYF 2175
Query: 288 RQVFNGVPVRMALLALVLG 306
RQ NGV VRM++L+L+LG
Sbjct: 2176 RQAKNGVFVRMSILSLLLG 2194
>pir||S42709 aspartate carbamoyltransferase (EC 2.1.3.2) - tomato (fragment)
>gi|397385|emb|CAA52201.1| (X74072) aspartate
carbamoyltransferase [Lycopersicon esculentum]
Length = 268
Score = 262 bits (663), Expect = 3e-69
Identities = 138/265 (52%), Positives = 183/265 (68%), Gaps = 3/265 (1%)
Query: 44 GKILATLFFEPSTRTRLSFESAMHRLGGAVIGFAEAST-SSVKKGESLRDTIKTVEQYCD 102
G ++ATLF+EPSTRTRLSFES+M RLGG V+ A SS KGE+L DTI+TVE Y D
Sbjct: 1 GYLMATLFYEPSTRTRLSFESSMKRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSD 60
Query: 103 VIVIRHPKEGAARLAAEVAEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLG 162
+IV+RH + GAAR AA A +P+INAGDG QHPTQ LLD+YTI +E G++DG+ I L+G
Sbjct: 61 IIVMRHFESGAARRAALSASIPIINAGDGPGQHPTQALLDVYTIGREIGKLDGINIALVG 120
Query: 163 DLKYGRTVHSLAEALTFY-DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGK 221
DL YGRTV SLA L Y DV++Y +SP++++M I + L G++ E+ L +V K
Sbjct: 121 DLAYGRTVRSLAHLLALYKDVKIYFVSPDVVKMKDDIKDYLTSMGVRWEESADLIEVASK 180
Query: 222 LDVLYVTRIQKERFPDEQE-YLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDN 280
DV+Y TRIQ+ERF + Y + +G Y V++ + + +MHPLPR+DEI +VD
Sbjct: 181 CDVVYQTRIQRERFGERVALYEEARGKYIVDMSAVNAMQKHAVVMHPLPRLDEITVDVDG 240
Query: 281 TKHAIYFRQVFNGVPVRMALLALVL 305
A YFRQ NG+ +RMALL L+L
Sbjct: 241 DPRAAYFRQAKNGLYIRMALLKLLL 265
>gb|AAD09129.1| (AF112473) PyrABCN [Aspergillus nidulans]
Length = 2275
Score = 256 bits (648), Expect = 2e-67
Identities = 127/289 (43%), Positives = 192/289 (65%), Gaps = 2/289 (0%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
+K + V+S+ F++ D+ + A+ + ++ +G L+ KG++L TLF+EPSTRT SF
Sbjct: 1952 FKQKHVLSVNQFNRADLHLLFTVAQEMRLGVQREGVLDILKGRLLCTLFYEPSTRTSASF 2011
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
+ AM RLGG I + SS KKGE+L+DT++T+ Y D +V+RHP+ + +AA+ +
Sbjct: 2012 DVAMQRLGGRTIAIS-TEHSSTKKGETLQDTLRTLGCYGDAVVLRHPEPSSTEVAAKFSP 2070
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VPVIN G+GS +HPTQ LDL+TI++E G + GL I GDLKYGR VHSL + L FYDV
Sbjct: 2071 VPVINGGNGSVEHPTQAFLDLFTIREELGTVGGLTITFTGDLKYGRPVHSLIKLLQFYDV 2130
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFPDEQEY 241
+ L++P+ L +P I ++L G + E+ L +++ + DVLY TR+QKERF D ++Y
Sbjct: 2131 RVQLVAPKDLSLPADIRQQLLATGQLLTESEELTPEIVARSDVLYSTRVQKERFADLEQY 2190
Query: 242 LKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQV 290
++K S+ ++ +L+ AK + +MHPLPR E+ EVD + A YFR V
Sbjct: 2191 ERLKNSFIIDNALLKHAKSHMVVMHPLPRNAEVSEEVDFDQRAAYFRLV 2239
>gi|9631738 contains carbamyltransferase motif; similar to Arabidopsis
aspartate transcarbamylase, corresponds to Swiss-Prot
Accession Number P49077 [Paramecium bursaria Chlorella
virus 1] >gi|7461315|pir||T17660 hypothetical protein
A169R - Chlorella virus PBCV-1
>gi|1131513|gb|AAC96537.1| (U42580) contains
carbamyltransferase motif; similar to Arabidopsis
aspartate transcarbamylase, corresponds to Swiss-Prot
Accession Number P49077 [Paramecium bursaria Chlorella
virus 1]
Length = 323
Score = 245 bits (620), Expect = 4e-64
Identities = 132/297 (44%), Positives = 184/297 (61%), Gaps = 6/297 (2%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ ++ + FSK+ ++ + A + + +GK + T F EPSTRTRLSFESA
Sbjct: 24 KHIVKSQQFSKQTVQELCILASEFKNVRNDS-----LRGKKMLTYFEEPSTRTRLSFESA 78
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
M+ LGG V+ A SS KGE++ DT++T+E+Y DV VIR G A AA V+ +PV
Sbjct: 79 MYDLGGYVMSVENAVNSSKAKGETIEDTVRTIERYADVFVIRSNTAGTAEKAARVSGIPV 138
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELY 185
INAGDG+ QHPTQ LLD+YTI +FG ++ L I ++GDL Y RTVHSL L+ + V +
Sbjct: 139 INAGDGAGQHPTQALLDVYTIYDKFGDLNDLTIVVVGDLLYSRTVHSLVYMLSLFKVRMI 198
Query: 186 LISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE-QEYLKV 244
++P +M + L++ G+ E+ LE V DV+Y+TRIQKERF D +Y K
Sbjct: 199 FVAPTECQMKYDLKNYLQDVGVVYEESNDLESVSKIADVVYMTRIQKERFTDRPDDYDKC 258
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
G Y ++ ++E+ K IMHPLPRVDEI P+VD A+YF QV G+ +R ALL
Sbjct: 259 VGKYIMSKMIVEQMKQNSIIMHPLPRVDEISPDVDTNHRAVYFDQVERGLEMRKALL 315
>dbj|BAA22792.1| (AB007852) aspartate carbamoyltransferase [Trypanosoma cruzi]
Length = 326
Score = 238 bits (602), Expect = 5e-62
Identities = 135/316 (42%), Positives = 199/316 (62%), Gaps = 15/316 (4%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KG+ + S FS+ DI ++ A ++R++ L +G+I+ LFFE S+RT SF
Sbjct: 11 KGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFC 70
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+AM RLGG+V+ F + SS+ KGE+L DTI+T++ Y DV+V+RHP++ A A VA+
Sbjct: 71 AAMIRLGGSVVNF-KVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQH 129
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEAL--TFYD 181
P++NAG+G+ +HPTQ LLD TI E G +DG+ I L+GDLK GRTVHSL + L F
Sbjct: 130 PILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSI 189
Query: 182 VELYLISPELLRMPRHIVE----ELREKGMKVVETTTLED-VIGKLDVLYVTRIQKERF- 235
++L++P+ L+MP+ ++E E+ KG+ + T L D V+ K DVLY TR+QKERF
Sbjct: 190 KCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFM 249
Query: 236 ---PDEQEYLK---VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQ 289
D+ L+ K ++ + AK+++ +MHPLPR DE+ VD A YFRQ
Sbjct: 250 ASTSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQ 309
Query: 290 VFNGVPVRMALLALVL 305
+ G+ +RMA+L VL
Sbjct: 310 MRYGMFMRMAILWSVL 325
>pir||T30522 aspartate carbamoyltransferase (EC 2.1.3.2) - Trypanosoma cruzi
>gi|4210457|dbj|BAA74525.1| (AB017765) ACTase
[Trypanosoma cruzi]
Length = 326
Score = 238 bits (600), Expect = 8e-62
Identities = 135/316 (42%), Positives = 199/316 (62%), Gaps = 15/316 (4%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KG+ + S FS+ DI ++ A ++R++ L +G+I+ LFFE S+RT SF
Sbjct: 11 KGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFC 70
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+AM RLGG+V+ F + SS+ KGE+L DTI+T++ Y DV+V+RHP++ A A VA+
Sbjct: 71 AAMIRLGGSVVNF-KVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQH 129
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEAL--TFYD 181
P++NAG+G+ +HPTQ LLD TI E G +DG+ I L+GDLK GRTVHSL + L F
Sbjct: 130 PILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSI 189
Query: 182 VELYLISPELLRMPRHIVE----ELREKGMKVVETTTLED-VIGKLDVLYVTRIQKERF- 235
++L++P+ L+MP+ ++E E+ KG+ + T L D V+ K DVLY TR+QKERF
Sbjct: 190 KCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFM 249
Query: 236 ---PDEQEYLK---VKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQ 289
D+ L+ K ++ + AK+++ +MHPLPR DE+ VD A YFRQ
Sbjct: 250 ASTSDDAAALQSFAAKTDITIDAARIRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQ 309
Query: 290 VFNGVPVRMALLALVL 305
+ G+ +RMA+L VL
Sbjct: 310 MRYGMFMRMAILWSVL 325
>dbj|BAA94298.1| (AB029444) Aspartate carbamoyltransferase [Leishmania mexicana
amazonensis]
Length = 327
Score = 238 bits (600), Expect = 8e-62
Identities = 133/317 (41%), Positives = 199/317 (61%), Gaps = 16/317 (5%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KG+ V S FS+ DI+ ++ A ++ ++ ++ +G+++ LFFE S+RT SF
Sbjct: 11 KGQSVASAAQFSRADIDALIQLALDMKTHIEAGKTIDALRGRVMTPLFFEDSSRTLSSFC 70
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+AM RLGG V+ F TSSV KGE+L+DT++T++ Y DV+V+RH KE A A VA
Sbjct: 71 AAMMRLGGGVVNFT-VETSSVNKGETLQDTVRTLDSYSDVLVLRHVKEEALEQAMSVATH 129
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT--FYD 181
P++NAG+G+ +HPTQ LLD+ TI E G +DG+ I L+GDLK GRTVHSL + LT F
Sbjct: 130 PIMNAGNGAGEHPTQALLDILTIHAELGAVDGITIALIGDLKKGRTVHSLLKLLTHNFAL 189
Query: 182 VELYLISPELLRMP----RHIVEELREKGMKVVETTTL-EDVIGKLDVLYVTRIQKERFP 236
++YLI+P L MP H+ +++++G+ + + L +V+ DVLY TR+QKERF
Sbjct: 190 RKVYLIAPAGLEMPAEVLEHVATDVQKRGITMEQACGLTPEVVADCDVLYATRLQKERFV 249
Query: 237 DE--------QEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFR 288
+ K S +++ L AK ++ +MHPLPRVDE+ ++D+ A YFR
Sbjct: 250 ASTAGDADAMAAFEASKASLRIDKARLAHAKAKMIVMHPLPRVDELSTDIDDDPRAGYFR 309
Query: 289 QVFNGVPVRMALLALVL 305
Q+ G+ +RMA+L VL
Sbjct: 310 QMRYGLFMRMAILFSVL 326
>gb|AAG21801.1|AF192346_1 (AF192346) aspartate transcarbamoylase [Burkholderia cepacia]
Length = 431
Score = 234 bits (591), Expect = 9e-61
Identities = 129/311 (41%), Positives = 188/311 (59%), Gaps = 12/311 (3%)
Query: 8 VISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMH 67
++S+ FS+E +E + A+ ++ + +G +L LFFE STRTR+SF +A
Sbjct: 92 LLSVDQFSRESVEALFRVADVMQPIARRHKISRVLEGAVLGNLFFEASTRTRVSFGAAFC 151
Query: 68 RLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPVIN 127
RLGG+V + SS+ KGES+ DT + + Y D VIRHP++G+ A +PVIN
Sbjct: 152 RLGGSVCDTTGFTFSSMAKGESIYDTSRVMAGYVDAFVIRHPEKGSVAEFARATNLPVIN 211
Query: 128 AGDGSNQHPTQTLLDLYTIKKEFGR----IDGLKIGLLGDLKYGRTVHSLAEALTFY-DV 182
GDG +HP+Q LLDLYTI++EF R +DG I L+GDLKYGRTVHSL + L Y +
Sbjct: 212 GGDGPGEHPSQALLDLYTIQREFSRLGKIVDGAHIALVGDLKYGRTVHSLVKLLALYRGL 271
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYL 242
+ L+SP L MP +IV+++ G + +TT L + DV+Y TRIQKERF DE +
Sbjct: 272 KFTLVSPPTLEMPAYIVDQIATNGHVIEQTTDLAAGLRGADVVYATRIQKERFTDE-SFE 330
Query: 243 KVKGSYQVNLKVLEK-AKDELRIMHPLPR-----VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+Q+N +++ K + IMHPLPR +++ +++ FRQ NG+PV
Sbjct: 331 GYTPDFQINQALVDTVCKPDTLIMHPLPRDSRPGANDLSVDLNRDPRLAIFRQTDNGIPV 390
Query: 297 RMALLALVLGV 307
RMA+ A++LGV
Sbjct: 391 RMAIFAVLLGV 401
>pir||S47625 aspartate carbamoyltransferase (EC 2.1.3.2) - wheat (fragment)
>gi|688218|gb|AAB31820.1| aspartate carbamoyltransferase
{C-terminal} {EC 2.1.3.2} [Triticum aestivum=wheat,
avalon, seedlings, Peptide Partial, 233 aa]
Length = 233
Score = 230 bits (581), Expect = 1e-59
Identities = 120/222 (54%), Positives = 158/222 (71%), Gaps = 2/222 (0%)
Query: 86 KGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPVINAGDGSNQHPTQTLLDLYT 145
KGE+L DTI+TVE Y D+IV+RH + GAAR AA AE+PVINAGDG QHPTQ LLD+YT
Sbjct: 2 KGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAEIPVINAGDGPGQHPTQALLDVYT 61
Query: 146 IKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY-DVELYLISPELLRMPRHIVEELRE 204
IK+E GR+DG+K+GL+GDL GRTV SLA + Y ++++Y +SP++++M I E L
Sbjct: 62 IKREIGRLDGIKLGLVGDLANGRTVRSLAYLIAKYQNIKIYFVSPDVVKMKDDIKEYLTS 121
Query: 205 KGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE-QEYLKVKGSYQVNLKVLEKAKDELR 263
+G++ E++ L DV + DV+Y TRIQKERF + Y +G Y V+ KVL A
Sbjct: 122 QGVEWEESSDLLDVASRCDVIYQTRIQKERFGERIDHYEAARGKYIVDKKVLRCAAKHAV 181
Query: 264 IMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVL 305
IMHPLPR+DEI +VD+ A YFRQ NG+ +RMALL L+L
Sbjct: 182 IMHPLPRLDEITVDVDSDPRAAYFRQAKNGLYIRMALLKLLL 223
>gb|AAB86625.1| (AF031144) aspartate transcarbamoylase [Plasmodium falciparum]
Length = 339
Score = 228 bits (575), Expect = 7e-59
Identities = 122/315 (38%), Positives = 189/315 (59%), Gaps = 14/315 (4%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
K + VI+I D E++ +L T+++ E+ LK +Y + K+ ++F EPSTRTR SF+
Sbjct: 20 KNKSVINIDDVDDEELLAILYTSKQFEKILKNNEDSKYLENKVFCSVFLEPSTRTRCSFD 79
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+A+ +LG V+ + +++S KGE++ D K + Y D I+ R P + +A +
Sbjct: 80 AAILKLGSKVLNITDMNSTSFYKGETVEDAFKILSTYVDGIIYRDPSKKNVDIAVSSSSK 139
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRI------DGLKIGLLGDLKYGRTVHSLAEAL 177
P+INAG+G+ +HPTQ+LLD YTI F I L I +GDLK GRTVHSL++ L
Sbjct: 140 PIINAGNGTGEHPTQSLLDFYTIHNYFPFILDRNINKKLNIAFVGDLKNGRTVHSLSKLL 199
Query: 178 TFYDVELYLISPELLRMPRHIVEELREKGMK--------VVETTTLEDVIGKLDVLYVTR 229
+ Y+V +S + L +P+ IV + K + LE+ + + ++Y+TR
Sbjct: 200 SRYNVSFNFVSCKSLNIPKDIVNTITYNLKKNNFYSDDSIKYFDNLEEGLEDVHIIYMTR 259
Query: 230 IQKERFPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQ 289
IQKERF D EY + K ++ ++ K LE +D+ +I+HPLPRV+EI EVD+ ++YF Q
Sbjct: 260 IQKERFTDVDEYNQYKNAFILSNKTLENTRDDTKILHPLPRVNEIKVEVDSNPKSVYFTQ 319
Query: 290 VFNGVPVRMALLALV 304
NG+ VRMALL L+
Sbjct: 320 AENGLYVRMALLYLI 334
>sp|P05990|PYR1_DROME CAD PROTEIN (RUDIMENTARY PROTEIN) [INCLUDES: GLUTAMINE-DEPENDENT
CARBAMOYL-PHOSPHATE SYNTHASE ; ASPARTATE
CARBAMOYLTRANSFERASE ; DIHYDROOROTASE ]
>gi|2144531|pir||QZFF rudimentary protein - fruit fly
(Drosophila melanogaster)
Length = 2236
Score = 202 bits (508), Expect = 5e-51
Identities = 115/302 (38%), Positives = 181/302 (59%), Gaps = 3/302 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++++ F+K+ + + A+ L+ + + GKI+A++F+E STRT SF +
Sbjct: 1922 GKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVALLPGKIMASVFYEVSTRTPCSFAA 1981
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGG VI + TSSVKKGE+ R + ++RHP GA +A
Sbjct: 1982 AMLRLGGRVISM-DNITSSVKKGETWRTASRLCPAMPTSWLLRHPSPGA--VARTTFSQS 2038
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
++ +H Q LLD++T + G ++GL I ++GDLK GRTVHSLA LT Y+V L
Sbjct: 2039 RLSMPACRREHSHQALLDIFTDPRVGGTVNGLTITMVGDLKNGRTVHSLARLLTLYNVNL 2098
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
++P L+MP +V+ + ++G+K + L++V+ DVLY+TRIQ+ERF + ++Y K
Sbjct: 2099 QYVAPNSLQMPDEVVQFVHQRGVKQLFARDLKNVLPDTDVLYMTRIQRERFDNVEDYEKC 2158
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
G + + + +AK ++HPLPR++EI E+D A YFRQ G+ +RMALLA+V
Sbjct: 2159 CGHLVLTPEHMMRAKKRSIVLHPLPRLNEISREIDLDPRAAYFRQAEYGMYIRMALLAMV 2218
Query: 305 LG 306
+G
Sbjct: 2219 VG 2220
>gb|AAA37009.1| (M33702) dihydroorotase synthetase complex (EC 3.5.2.3) [Cricetulus
sp.]
Length = 708
Score = 192 bits (484), Expect = 3e-48
Identities = 94/189 (49%), Positives = 138/189 (72%), Gaps = 1/189 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++S++ F+K+ + + A L ++++ L+ KGK++A++F+E STRT SF +
Sbjct: 521 GQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAA 580
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGGAV+ F+EA TSSV+KGESL D+++T+ Y DV+V+RHP+ GA LAA+ P
Sbjct: 581 AMARLGGAVLSFSEA-TSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP 639
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VINAGDG +HPTQ LLD++TI++E G ++G+ I ++GDLK+GRTVHSLA LT Y V L
Sbjct: 640 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL 699
Query: 185 YLISPELLR 193
++P LR
Sbjct: 700 RYVAPPSLR 708
>pir||D75435 aspartate carbamoyltransferase - Deinococcus radiodurans (strain
R1) >gi|6458844|gb|AAF10682.1|AE001961_1 (AE001961)
aspartate carbamoyltransferase [Deinococcus radiodurans]
Length = 314
Score = 173 bits (434), Expect = 2e-42
Identities = 117/308 (37%), Positives = 169/308 (53%), Gaps = 25/308 (8%)
Query: 6 RDVISIRDFSKEDIETVLATAER----LERELKEKGQLEYAKGKILATLFFEPSTRTRLS 61
R ++ +D++ E +E VL A+ L+R +K+ L+ G + T FFE STRTR S
Sbjct: 12 RHLLDFQDWTPERLEAVLDNADTMLQVLDRPVKKVPALQ---GLTVCTAFFENSTRTRTS 68
Query: 62 FESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEV 120
FE A R+ V+ FA A SSV KGESLRDTI+ + Y D V+RH GAA L A+
Sbjct: 69 FELAARRMSADVVSFA-AGNSSVSKGESLRDTIEVLTAYKVDAYVVRHHAAGAAHLVAKY 127
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY 180
+ PVINAGDG HPTQ LLD YTI++E+G ++G K+ ++GD+++ R S AE L
Sbjct: 128 SGKPVINAGDGRRAHPTQALLDAYTIRQEYGSLEGKKVAIIGDIRHSRVARSNAELLPKL 187
Query: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKER-----F 235
E+ L P L P + + G+++ TT + + + R+Q+ER
Sbjct: 188 GAEVVLCGPATLLPP----DLAGQPGVRL--TTDPREAVRGAHAVMALRLQQERMNGGYL 241
Query: 236 PDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNG 293
QEY +YQVN ++ +A+ ++HP P R EI E + + RQV NG
Sbjct: 242 ASLQEY---ADTYQVNETLMREAESGAIVLHPGPMNRDLEISTEAADGPRSRIIRQVENG 298
Query: 294 VPVRMALL 301
VRM++L
Sbjct: 299 QAVRMSVL 306
>emb|CAB93367.1| (AL357523) aspartate carbamoyltransferase [Streptomyces coelicolor
A3(2)]
Length = 326
Score = 164 bits (412), Expect = 9e-40
Identities = 120/320 (37%), Positives = 174/320 (53%), Gaps = 30/320 (9%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEK-GQLEYAKGKILATLFFEPSTRTRLSFES 64
R +IS D +++D +L TAE + R +L +G+ + LFFE STRTR+SFE+
Sbjct: 3 RHLISAADLTRDDAVLILDTAEEMARVADRPIKKLPTLRGRTVVNLFFEDSTRTRISFEA 62
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAA-RLAAE-VA 121
A RL VI F A SSV KGESL+DT +T+E D +VIRH GA RLA
Sbjct: 63 AEKRLSADVINFT-AKGSSVSKGESLKDTAQTLEAMGVDAVVIRHSASGAPYRLATSGWI 121
Query: 122 EVPVINAGDGSNQHPTQTLLDLYTIKKEF-GR-------IDGLKIGLLGDLKYGRTVHSL 173
+ V+NAGDG++QHPTQ LLD +T+++ GR +DG +I L+GD+ + R S
Sbjct: 122 DAAVVNAGDGTHQHPTQALLDAFTMRRRLVGRDAGLGKDLDGRRITLVGDILHSRVARSN 181
Query: 174 AEALTFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKE 233
+ L E+ L++P L +P + + + L+ + K D + + R+Q+E
Sbjct: 182 VDLLHTLGAEVTLVAPPTL-LPVGV------ETWPCEVSYDLDSTLPKSDAVMLLRVQRE 234
Query: 234 R-----FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVD--EIHPEVDNTKHAIY 286
R FP E+EY + Y ++ + K D +MHP P V EI EV ++
Sbjct: 235 RMNAAFFPTEREYSR---RYGLDGDRMAKMPDHAIVMHPGPMVRGMEITAEVADSDRCTV 291
Query: 287 FRQVFNGVPVRMALLALVLG 306
QV NGV +RMA+L L+LG
Sbjct: 292 VEQVTNGVSIRMAVLYLLLG 311
>sp|P96079|PYRB_THEAQ ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|1684759|emb|CAA70729.1| (Y09536) aspartate
carbamoyltransferase (ATCase) [Thermus aquaticus]
Length = 301
Score = 164 bits (410), Expect = 2e-39
Identities = 112/304 (36%), Positives = 169/304 (54%), Gaps = 21/304 (6%)
Query: 6 RDVISIRDFSKEDIETVLATA----ERLERELKEKGQLEYAKGKILATLFFEPSTRTRLS 61
R ++ + +++ ++E++L TA E LER +K+ L+ G +AT+FFEPSTRTR+S
Sbjct: 2 RHLLDFQGWTRPEVESLLDTARVMREVLERPVKKVPALQ---GFTVATVFFEPSTRTRIS 58
Query: 62 FESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEV 120
FE A R+ V+ FA A TSS++KGES +DT+ T+E D VIR G A
Sbjct: 59 FELAARRMSADVVSFA-AQTSSLQKGESYKDTLLTLEAMGVDAYVIRADSAGVPHQATRW 117
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFY 180
+ VIN GDG HPTQ LLD YT+ + G ++G K+ ++GD+ + R S AE L
Sbjct: 118 VKGAVINGGDGRRAHPTQALLDAYTLLEALGTLEGKKVAIVGDILHSRVARSNAELLPLL 177
Query: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQE 240
+++ P L +P+ + G + T LE+ + + D + V R+QKER
Sbjct: 178 GAQVFCAGPPSL-LPQSL------PGAHL--TPRLEEALEEADAVMVLRLQKERMEAGLV 228
Query: 241 YLK-VKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVR 297
+L+ YQV K L AK + ++HP P R E+ + ++ ++ RQV NGV VR
Sbjct: 229 HLEDYIARYQVTEKRLALAKPQAPLLHPGPMNRDVELEGTLADSARSLVNRQVQNGVAVR 288
Query: 298 MALL 301
MA+L
Sbjct: 289 MAVL 292
>dbj|BAB06258.1| (AP001515) aspartate carbamoyltransferase [Bacillus halodurans]
Length = 305
Score = 163 bits (409), Expect = 2e-39
Identities = 112/305 (36%), Positives = 163/305 (52%), Gaps = 22/305 (7%)
Query: 7 DVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKI-LATLFFEPSTRTRLSFESA 65
D++++ S E+IE +L A++ E G L + K+ +A LFFEPSTRTR+SFE A
Sbjct: 14 DLLTMSHLSLEEIEHILHDAQQFEN-----GALWSPEEKLFVANLFFEPSTRTRVSFEVA 68
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEVAEVP 124
RLG V+ + SSV+KGE+L DT KT+E + +VIRH ++ + +P
Sbjct: 69 EQRLGLHVVN-VDGERSSVQKGETLYDTAKTLESIGVNALVIRHRQDRYFEELKDRINIP 127
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
+INAGDG HPTQ+LLDL+TI++EFGR L + GDL++ R S AE LT +
Sbjct: 128 IINAGDGCGHHPTQSLLDLWTIQQEFGRFSNLITVISGDLRHSRVARSNAETLTRLGARV 187
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
Y+ P E E V T+++ + DV+ + R+Q ER + +
Sbjct: 188 YISGP----------REWMEGYEGVYPYVTMDEAVELADVIMLLRVQHERHDGTVSFTQA 237
Query: 245 KGSYQVNLKVLEKA--KDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
Q L V +A K + +MHP P R EI E+ + F+Q+ NGV +RMA+
Sbjct: 238 SYHEQFGLTVKREARMKPKSIVMHPAPVNRNVEIASELVECPRSRIFKQMKNGVAIRMAV 297
Query: 301 LALVL 305
L L
Sbjct: 298 LKRAL 302
>sp|P05654|PYRB_BACSU ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|279485|pir||OWBSAC aspartate
carbamoyltransferase (EC 2.1.3.2) catalytic chain
[validated] - Bacillus subtilis
>gi|143384|gb|AAA22685.1| (M13128) aspartate
transcarbamoylase (EC 2.1.3.2) [Bacillus subtilis]
>gi|143387|gb|AAA21267.1| (M59757) aspartate
transcarbamylase [Bacillus subtilis]
>gi|2633922|emb|CAB13423.1| (Z99112) aspartate
carbamoyltransferase [Bacillus subtilis]
Length = 304
Score = 161 bits (404), Expect = 8e-39
Identities = 108/303 (35%), Positives = 159/303 (51%), Gaps = 18/303 (5%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ + ++ + S E+I+ +L TA+ L+ K QL GK A LFFEPSTRTR SFE A
Sbjct: 2 KHLTTMSELSTEEIKDLLQTAQELKSG-KTDNQLT---GKFAANLFFEPSTRTRFSFEVA 57
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEVAEVP 124
+LG V+ STS V+KGE+L DTI+T+E DV VIRH ++ +P
Sbjct: 58 EKKLGMNVLNLDGTSTS-VQKGETLYDTIRTLESIGVDVCVIRHSEDEYYEELVSQVNIP 116
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
++NAGDG QHPTQ+LLDL TI +EF GL + + GD+K+ R S AE LT +
Sbjct: 117 ILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSRVARSNAEVLTRLGARV 176
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
P E +++ ++++ + DV+ + RIQ ER
Sbjct: 177 LFSGP----------SEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQSAVSQEGY 226
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
Y + ++ E+ K IMHP P R EI + ++ + F+Q+ NGV +RMA++
Sbjct: 227 LNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKNGVFIRMAVIQ 286
Query: 303 LVL 305
L
Sbjct: 287 CAL 289
>pdb|2AT2|A Chain A, Aspartate Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) >gi|494730|pdb|2AT2|B Chain B,
Aspartate Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase) >gi|494731|pdb|2AT2|C Chain C,
Aspartate Transcarbamoylase (E.C.2.1.3.2) (Aspartate
Carbamoyltransferase)
Length = 300
Score = 161 bits (404), Expect = 8e-39
Identities = 108/303 (35%), Positives = 159/303 (51%), Gaps = 18/303 (5%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ + ++ + S E+I+ +L TA+ L+ K QL GK A LFFEPSTRTR SFE A
Sbjct: 2 KHLTTMSELSTEEIKDLLQTAQELKSG-KTDNQLT---GKFAANLFFEPSTRTRFSFEVA 57
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEVAEVP 124
+LG V+ STS V+KGE+L DTI+T+E DV VIRH ++ +P
Sbjct: 58 EKKLGMNVLNLDGTSTS-VQKGETLYDTIRTLESIGVDVCVIRHSEDEYYEELVSQVNIP 116
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
++NAGDG QHPTQ+LLDL TI +EF GL + + GD+K+ R S AE LT +
Sbjct: 117 ILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSRVARSNAEVLTRLGARV 176
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKV 244
P E +++ ++++ + DV+ + RIQ ER
Sbjct: 177 LFSGP----------SEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQSAVSQEGY 226
Query: 245 KGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLA 302
Y + ++ E+ K IMHP P R EI + ++ + F+Q+ NGV +RMA++
Sbjct: 227 LNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKNGVFIRMAVIQ 286
Query: 303 LVL 305
L
Sbjct: 287 CAL 289
>sp|P41008|PYRB_BACCL ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|312440|emb|CAA51736.1| (X73308) aspartate
carbamoyltransferase [Bacillus caldolyticus]
Length = 308
Score = 159 bits (398), Expect = 4e-38
Identities = 106/300 (35%), Positives = 159/300 (52%), Gaps = 22/300 (7%)
Query: 8 VISIRDFSKEDIETVLATAERLERELKEKGQL-EYAKGKILATLFFEPSTRTRLSFESAM 66
+ ++ + ++I +L AER G++ A +A LFFEPSTRT+ SFE A
Sbjct: 4 LFALSELPLDEIHRLLDEAERFR-----SGRIWRPAAPMYVANLFFEPSTRTKCSFEMAE 58
Query: 67 HRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEVAEVPV 125
+LG VI F + SSV+KGE+L DT++T+E D +VIRH ++ +P+
Sbjct: 59 RKLGLHVIPF-DPERSSVQKGETLYDTVRTLEAIGVDAVVIRHHEDAYFEALRHAVGIPI 117
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELY 185
INAGDG HPTQ+LLDL TI++EFG GL + ++GD+++ R S AE LT +
Sbjct: 118 INAGDGCGHHPTQSLLDLLTIRQEFGAFTGLTVAIIGDIRHSRVARSNAEVLTRLGANVL 177
Query: 186 LISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVK 245
P EE +++ +++ I + DV+ + RIQ ER + K +
Sbjct: 178 FSGP----------EEWKDETNPYGTYVEVDEAIARADVVMLLRIQHERHAETMGLTKEE 227
Query: 246 --GSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
Y + L+ + K I+HP P R EI E+ K + F+Q+ NGV VRMA+L
Sbjct: 228 YHARYGLTLERARRMKSGAIILHPAPVNRGVEIASELVEAKASRIFKQMENGVYVRMAVL 287
>pir||I40166 aspartate carbamoyltransferase (EC 2.1.3.2) - Bacillus caldolyticus
Length = 308
Score = 159 bits (398), Expect = 4e-38
Identities = 106/300 (35%), Positives = 159/300 (52%), Gaps = 22/300 (7%)
Query: 8 VISIRDFSKEDIETVLATAERLERELKEKGQL-EYAKGKILATLFFEPSTRTRLSFESAM 66
+ ++ + ++I +L AER G++ A +A LFFEPSTRT+ SFE A
Sbjct: 4 LFALSELPLDEIHRLLDEAERFR-----SGRIWRPAAPMYVANLFFEPSTRTKCSFEMAE 58
Query: 67 HRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEVAEVPV 125
+LG VI F + SSV+KGE+L DT++T+E D +VIRH ++ +P+
Sbjct: 59 RKLGLHVIPF-DPERSSVQKGETLYDTVRTLEAIGVDAVVIRHHEDAYFEALRHAVGIPI 117
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELY 185
INAGDG HPTQ+LLDL TI++EFG GL + ++GD+++ R S AE LT +
Sbjct: 118 INAGDGCGHHPTQSLLDLLTIRQEFGAFTGLTVAIIGDIRHSRVARSNAEVLTRLGANVL 177
Query: 186 LISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVK 245
P EE +++ +++ I + DV+ + RIQ ER + K +
Sbjct: 178 FSGP----------EEWKDETNPYGTYVEVDEAIARADVVMLLRIQHERHAETMGLTKEE 227
Query: 246 --GSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMALL 301
Y + L+ + K I+HP P R EI E+ K + F+Q+ NGV VRMA+L
Sbjct: 228 YHARYGLTLERARRMKSGAIILHPAPVNRGVEIASELVEAKASRIFKQMENGVYVRMAVL 287
>pir||C33917 pyrimidine synthesis protein CAD - Chinese hamster (fragment)
Length = 156
Score = 155 bits (389), Expect = 4e-37
Identities = 73/152 (48%), Positives = 112/152 (73%), Gaps = 1/152 (0%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++S++ F+K+ + + A L ++++ L+ KGK++A++F+E STRT SF +
Sbjct: 6 GQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAA 65
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGGAV+ F+EA TSSV+KGESL D+++T+ Y DV+V+RHP+ GA LAA+ P
Sbjct: 66 AMARLGGAVLSFSEA-TSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP 124
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGL 156
VINAGDG +HPTQ LLD++TI++E G ++G+
Sbjct: 125 VINAGDGVGEHPTQALLDIFTIREELGTVNGM 156
>sp|P77883|PYRB_LACPL ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|1514600|emb|CAA91002.1| (Z54240) aspartate
carbamoyltransferase, aspartate transcarbamylase,
carbamylaspartotranskinase [Lactobacillus plantarum]
Length = 311
Score = 155 bits (387), Expect = 8e-37
Identities = 107/308 (34%), Positives = 162/308 (51%), Gaps = 22/308 (7%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
++++S+ FS +D+ L +L + K ++ ++ LFFE STRT SFE A
Sbjct: 5 QNLVSVEQFSNQDVMAYL----KLAQAFKNGKTVQLSQPTFAMNLFFENSTRTHTSFEMA 60
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEVA-EV 123
RLG VI F + TSSV KGESL DT+KT+E ++ V+RHP++ + + ++
Sbjct: 61 ERRLGLQVIPF-DPKTSSVTKGESLLDTLKTIEAIGVNLAVVRHPRDRYYQPLLDAGFDM 119
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
+INAGDGS QHP+Q+LLD+ TI +EFG DGLKI ++GDL + R S LT +
Sbjct: 120 SLINAGDGSGQHPSQSLLDMLTIYEEFGHFDGLKIAIVGDLAHSRVARSNMALLTQLGAQ 179
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLK 243
+Y P+ E E T++ ++ +DV+ + R+Q ER
Sbjct: 180 VYFGGPK---------EWYGRDFEAYGEYQTMDQLVATMDVMMLLRVQHERLSQVNNQTF 230
Query: 244 VKGSY--QVNLKVLEKAK--DELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVR 297
+Y Q L A+ IMHP P R E+ ++ + F+Q+ NGV +R
Sbjct: 231 DASAYHQQYGLTAERAARMPKHAIIMHPAPVNRGVELASDLVEAPQSRIFQQMTNGVYIR 290
Query: 298 MALLALVL 305
MA++A VL
Sbjct: 291 MAMVASVL 298
>sp|Q59711|PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|1360919|pir||A56144 aspartate
carbamoyltransferase (EC 2.1.3.2) 36k catalytic chain -
Pseudomonas putida (strain PpN-1)
>gi|151521|gb|AAD15279.1| (M97253) aspartate
carbamoyltransferase [Pseudomonas putida]
Length = 334
Score = 150 bits (374), Expect = 3e-35
Identities = 108/312 (34%), Positives = 166/312 (52%), Gaps = 23/312 (7%)
Query: 6 RDVISIRDFSKEDIETVLATAER-LERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
R +S+ +E + +L TA+ LE + ++ +GK + +FFE STRTR +FE
Sbjct: 19 RHFLSLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFEL 78
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYC-DVIVIRHPKEGAARLAAE--VA 121
A RL VI STSS KGE+L DT++ +E D+ V+RH GAA AE
Sbjct: 79 AAQRLSADVISL-NVSTSSTSKGETLFDTLRNLEAMAADMFVVRHSDSGAAHFIAEHVCP 137
Query: 122 EVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD 181
+V VIN GDG + HPTQ +LD+ TI++ G + L + ++GD+ + R S AL
Sbjct: 138 DVAVINGGDGRHAHPTQGMLDMLTIRRHKGSFENLSVAIVGDILHSRVARSDMLALKALG 197
Query: 182 V-ELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKER-----F 235
++ +I P+ L I + + G+KV T L + + +DV+ + R+Q+ER
Sbjct: 198 CPDIRVIGPKTL-----IPIGIEQYGVKVY--TDLAEGLKDVDVVIMLRLQRERMAGGLL 250
Query: 236 PDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNG 293
P E E+ ++ G L AK + +MHP P R EI V + KH++ QV G
Sbjct: 251 PSEGEFYRLFGLTTARLAC---AKPDAIVMHPGPINRGVEIESAVADGKHSVILNQVTYG 307
Query: 294 VPVRMALLALVL 305
+ VRMA+L++ +
Sbjct: 308 IAVRMAVLSMAM 319
>pir||H83595 aspartate carbamoyltransferase PA0402 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9946256|gb|AAG03791.1|AE004477_8 (AE004477)
aspartate carbamoyltransferase [Pseudomonas aeruginosa]
Length = 334
Score = 150 bits (374), Expect = 3e-35
Identities = 108/312 (34%), Positives = 169/312 (53%), Gaps = 22/312 (7%)
Query: 6 RDVISIRDFSKEDIETVLATAER-LERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
R IS+ +E + +L TA+ LE + ++ +GK + +FFE STRTR +FE
Sbjct: 18 RHFISLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFEL 77
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYC-DVIVIRHPKEGAARLAAEVAE- 122
A RL VI STSS KGE+L DT++ +E D+ V+RH GAA AE
Sbjct: 78 AAQRLSADVISL-NVSTSSTSKGETLTDTLRNLEAMAADMFVVRHSDSGAAHFIAEHVSP 136
Query: 123 -VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEAL-TFY 180
V VIN GDG + HPTQ +LD+ TI++ G + L + ++GD+ + R S AL T
Sbjct: 137 NVAVINGGDGRHAHPTQGMLDMLTIRRHKGNFEQLSVAIVGDILHSRVARSNMLALKTLG 196
Query: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKER-----F 235
++ +I+P L +P + E+ G++V T ++ + +DV+ + R+Q+ER
Sbjct: 197 CPDIRVIAPRTL-LPIGLEEQY---GVRVF--TNADEGLKDVDVVIMLRLQRERMQGGLL 250
Query: 236 PDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNG 293
P E E+ K+ G + LK+ AK + +MHP P R EI V + ++ QV G
Sbjct: 251 PSEGEFFKLYGLTEKRLKL---AKPDAIVMHPGPINRGVEIESAVADGAQSVILNQVTYG 307
Query: 294 VPVRMALLALVL 305
+ +RMA+L++ +
Sbjct: 308 IAIRMAVLSMAM 319
>sp|Q59653|PYRB_PSEAE ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|309885|gb|AAA25976.1| (L19649) 'aspartate
transcarbamoylase' [Pseudomonas aeruginosa]
Length = 334
Score = 149 bits (373), Expect = 3e-35
Identities = 108/312 (34%), Positives = 169/312 (53%), Gaps = 22/312 (7%)
Query: 6 RDVISIRDFSKEDIETVLATAER-LERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
R IS+ +E + +L TA+ LE + ++ +GK + +FFE STRTR +FE
Sbjct: 18 RHFISLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFEL 77
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYC-DVIVIRHPKEGAARLAAEVAE- 122
A RL VI STSS KGE+L DT++ +E D+ V+RH GAA AE
Sbjct: 78 AAQRLSADVISL-NVSTSSTSKGETLTDTLRNLEAMAADMFVVRHSDSGAAHFIAEHVSP 136
Query: 123 -VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEAL-TFY 180
V VIN GDG + HPTQ +LD+ TI++ G + L + ++GD+ + R S AL T
Sbjct: 137 NVAVINGGDGRHAHPTQGMLDMLTIRRHKGNFEQLSVAIVGDILHSRVARSNMLALKTLG 196
Query: 181 DVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKER-----F 235
++ +I+P L +P + E+ G++V T ++ + +DV+ + R+Q+ER
Sbjct: 197 CPDIRVIAPATL-LPIGLEEQY---GVRVF--TNADEGLKDVDVVIMLRLQRERMQGGLL 250
Query: 236 PDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNG 293
P E E+ K+ G + LK+ AK + +MHP P R EI V + ++ QV G
Sbjct: 251 PSEGEFFKLYGLTEKRLKL---AKPDAIVMHPGPINRGVEIESAVADGAQSVILNQVTYG 307
Query: 294 VPVRMALLALVL 305
+ +RMA+L++ +
Sbjct: 308 IAIRMAVLSMAM 319
>pir||A48948 aspartate carbamoyltransferase (EC 2.1.3.2) - Treponema denticola
>gi|217168|dbj|BAA00941.1| (D10052) asparate
carbamoyltransferase [Treponema denticola]
Length = 475
Score = 147 bits (367), Expect = 2e-34
Identities = 110/333 (33%), Positives = 173/333 (51%), Gaps = 31/333 (9%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKI------LATLFFEPSTRT 58
GR + I D S ++ + + +RL++ ++E Q + +I + +F EPSTRT
Sbjct: 7 GRSLTVIDDLSIDERKYLFDKTKRLKKAIQEDDQKVMDEFRINDKDFGIYEVFLEPSTRT 66
Query: 59 RLSFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCD-VIVIRHPKEGAARLA 117
+ SF +A + + A +SS KGES DT T+ Y + + ++R EG R
Sbjct: 67 KESFRNAA-KFHQVKLSDLAAESSSFNKGESYADTFNTLAGYQNSIFIVRSEVEGVCRWL 125
Query: 118 AEVAEV-----------PVINAGDGSNQHPTQTLLDLYT-IKKEFGRIDGLKIGLLGDLK 165
+ A+ INAGDG ++HPTQ LLD +T I+ D + I L+GDL
Sbjct: 126 EDEAQAFYQRNNLKRKPAFINAGDGKHEHPTQELLDEFTFIEDNNWSFDKIHIALVGDLY 185
Query: 166 YGRTVHSLAEAL-TFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDV 224
+GRTVHS A+ L F V++ LI+P L MP + ++E G V E +++E+ + + DV
Sbjct: 186 HGRTVHSKADGLKIFKSVKVDLIAPAELAMPEYYKVRMQENGFTVREFSSIEEYLRQADV 245
Query: 225 L---YVTRIQKERFPDE--QEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEV- 278
Y TR Q ER ++ ++ +++ S + +EK + R HPLPR +HP +
Sbjct: 246 ALIWYFTRPQLERMGEQVLKKQDELRRSITFRKEFIEKLPENTRFYHPLPR-HRVHPTIP 304
Query: 279 ---DNTKHAIYFRQVFNGVPVRMALLALVLGVI 308
D T + RQ NG+ VRM LL+++ G I
Sbjct: 305 TFLDATPLNGWERQSINGMYVRMVLLSMIAGKI 337
>sp|Q04595|PYRB_TREDE PYRBI PROTEIN [INCLUDES: ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE
TRANSCARBAMYLASE) (ATCASE); ASPARTATE
CARBAMOYLTRANSFERASE REGULATORY REGION]
Length = 535
Score = 147 bits (367), Expect = 2e-34
Identities = 110/333 (33%), Positives = 173/333 (51%), Gaps = 31/333 (9%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKI------LATLFFEPSTRT 58
GR + I D S ++ + + +RL++ ++E Q + +I + +F EPSTRT
Sbjct: 7 GRSLTVIDDLSIDERKYLFDKTKRLKKAIQEDDQKVMDEFRINDKDFGIYEVFLEPSTRT 66
Query: 59 RLSFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCD-VIVIRHPKEGAARLA 117
+ SF +A + + A +SS KGES DT T+ Y + + ++R EG R
Sbjct: 67 KESFRNAA-KFHQVKLSDLAAESSSFNKGESYADTFNTLAGYQNSIFIVRSEVEGVCRWL 125
Query: 118 AEVAEV-----------PVINAGDGSNQHPTQTLLDLYT-IKKEFGRIDGLKIGLLGDLK 165
+ A+ INAGDG ++HPTQ LLD +T I+ D + I L+GDL
Sbjct: 126 EDEAQAFYQRNNLKRKPAFINAGDGKHEHPTQELLDEFTFIEDNNWSFDKIHIALVGDLY 185
Query: 166 YGRTVHSLAEAL-TFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDV 224
+GRTVHS A+ L F V++ LI+P L MP + ++E G V E +++E+ + + DV
Sbjct: 186 HGRTVHSKADGLKIFKSVKVDLIAPAELAMPEYYKVRMQENGFTVREFSSIEEYLRQADV 245
Query: 225 L---YVTRIQKERFPDE--QEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEV- 278
Y TR Q ER ++ ++ +++ S + +EK + R HPLPR +HP +
Sbjct: 246 ALIWYFTRPQLERMGEQVLKKQDELRRSITFRKEFIEKLPENTRFYHPLPR-HRVHPTIP 304
Query: 279 ---DNTKHAIYFRQVFNGVPVRMALLALVLGVI 308
D T + RQ NG+ VRM LL+++ G I
Sbjct: 305 TFLDATPLNGWERQSINGMYVRMVLLSMIAGKI 337
>sp|P71808|PYRB_MYCTU ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433609|pir||A70959 probable aspartate
carbamoyltransferase - Mycobacterium tuberculosis
(strain H37RV) >gi|1621262|emb|CAB02641.1| (Z81011) pyrB
[Mycobacterium tuberculosis]
Length = 319
Score = 146 bits (365), Expect = 3e-34
Identities = 108/315 (34%), Positives = 163/315 (51%), Gaps = 26/315 (8%)
Query: 6 RDVISIRDFSKEDIETVLATAERLEREL--KEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
R +++ D S++D +L A+R + L ++ +L +G+ + T+F+E STRTR+SFE
Sbjct: 4 RHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGRTVVTMFYENSTRTRVSFE 63
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAARLAAEVAE 122
A + VI + A SSV KGESLRDT T+ D ++IRHP GAA L A+
Sbjct: 64 VAGKWMSADVINVSAAG-SSVGKGESLRDTALTLRAAGADALIIRHPASGAAHLLAQWTG 122
Query: 123 V-----PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEAL 177
VINAGDG+++HPTQ LLD TI++ G I+G +I ++GD+ + R S L
Sbjct: 123 AHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRIVIVGDILHSRVARSNVMLL 182
Query: 178 TFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKER--- 234
E+ L++P L +P + G + + + D + + R+Q ER
Sbjct: 183 DTLGAEVVLVAPPTL-LPVGVT------GWPATVSHDFDAELPAADAVLMLRVQAERMNG 235
Query: 235 --FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVD--EIHPEVDNTKHAIYFRQV 290
FP +EY G + +L ++HP P V EI V ++ + +QV
Sbjct: 236 GFFPSVREYSVRYGLTERRQAML---PGHAVVLHPGPMVRGMEITSSVADSSQSAVLQQV 292
Query: 291 FNGVPVRMALLALVL 305
NGV VRMA+L VL
Sbjct: 293 SNGVQVRMAVLFHVL 307
>sp|Q60252|PYRB_LACLE ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|1359907|emb|CAA59021.1| (X84262) aspartate
transcarbamylase [Lactobacillus leichmannii]
Length = 351
Score = 145 bits (363), Expect = 5e-34
Identities = 114/316 (36%), Positives = 161/316 (50%), Gaps = 34/316 (10%)
Query: 9 ISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILAT-LFFEPSTRTRLSFESAMH 67
+S+ S +D+ +L A+ K G++ I T +FFE STRT SFE A
Sbjct: 42 VSVEQLSADDVLHLLQRAQYF----KNGGEVPALSRPIFCTNMFFENSTRTHTSFEVAER 97
Query: 68 RLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPK-----EGAARLAAEVA 121
RLG VI F + S SSV KGE+L DT T+ ++ VIRHP+ E +
Sbjct: 98 RLGLTVIPF-DPSHSSVNKGENLYDTELTMASLGIELSVIRHPENAYYNEIIRPKEGQHL 156
Query: 122 EVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD 181
++ ++NAGDGS QHP+Q++LD+ TI EFG DGLKI ++GDL R S E L
Sbjct: 157 QMGLVNAGDGSGQHPSQSMLDMMTIYNEFGHFDGLKIMIVGDLTNSRVARSNMEILNTLG 216
Query: 182 VELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFP----- 236
E+Y PE + EE + G V ++D I +LDVL + R+Q ER
Sbjct: 217 AEVYFSGPEYW----YNAEEFSKYGTYV---KNIDDEIPELDVLMLLRVQHERHNGAEAK 269
Query: 237 -----DEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQ 289
D ++Y +Y +N + + KD+ IMHP P R E ++ + Y Q
Sbjct: 270 TEQLFDAKDY---NAAYGLNQRRYDMLKDDAIIMHPGPINRGVEWDGDLVEAPKSRYAVQ 326
Query: 290 VFNGVPVRMALLALVL 305
+ NGV VRMA++ VL
Sbjct: 327 MHNGVFVRMAMIEAVL 342
>gb|AAG15558.1| (AY007523) aspartate carbamoyl transferase PyrB [Pseudomonas
fluorescens]
Length = 334
Score = 145 bits (361), Expect = 8e-34
Identities = 103/309 (33%), Positives = 167/309 (53%), Gaps = 23/309 (7%)
Query: 9 ISIRDFSKEDIETVLATAER-LERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMH 67
+S+ +E + +L TA+ LE + ++ +GK + +FFE STRTR +FE A
Sbjct: 22 LSLDGLRRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFELAAQ 81
Query: 68 RLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYC-DVIVIRHPKEGAARLAAE--VAEVP 124
RL VI STSS KGE+L DT++ +E D+ V+RH GAA AE +V
Sbjct: 82 RLSADVITL-NVSTSSASKGETLLDTLRNLEAMAADMFVVRHGDSGAAHFIAEHVCPQVA 140
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEAL-TFYDVE 183
+IN GDG + HPTQ +LD+ TI++ G + L + ++GD+ + R S AL T +
Sbjct: 141 IINGGDGRHAHPTQGMLDMLTIRRHKGSFENLSVAIVGDILHSRVARSNMLALKTLGCPD 200
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKER-----FPDE 238
+ +I+P+ L + + + G+KV T + + + +DV+ + R+Q+ER P E
Sbjct: 201 IRVIAPKTL-----LPIGVEQYGVKVY--TDMTEGLKDVDVVIMLRLQRERMTGGLLPSE 253
Query: 239 QEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPV 296
E+ ++ G + L AK + +MHP P R EI V + H++ QV G+ +
Sbjct: 254 GEFYRLFG---LTTARLAGAKPDAIVMHPGPINRGVEIESAVADGPHSVILNQVTYGIAI 310
Query: 297 RMALLALVL 305
RMA+L++ +
Sbjct: 311 RMAVLSMAM 319
>sp|P74163|PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433608|pir||S75691 aspartate
carbamoyltransferase (EC 2.1.3.2) pyrB - Synechocystis
sp. (strain PCC 6803) >gi|1653337|dbj|BAA18252.1|
(D90912) aspartate carbamoyltransferase [Synechocystis
sp.]
Length = 331
Score = 144 bits (360), Expect = 1e-33
Identities = 108/325 (33%), Positives = 170/325 (52%), Gaps = 28/325 (8%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELK-EKGQLEYAKGKILATLFFEPSTRTRLS 61
W ++ + D+ E+++ VL TA ++ L + ++ +G+++ LFFEPSTRTR S
Sbjct: 7 WTRNHILDLTDWRGEELDIVLQTATTFQQVLSGQTKKVPALQGQVVTNLFFEPSTRTRSS 66
Query: 62 FESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKT-VEQYCDVIVIRHPKEGAARLAAEV 120
FE A RL V+ F+ TSS+ KGE++ DT KT + D+ VIRH + G A
Sbjct: 67 FELAAKRLSADVMNFS-PGTSSLTKGETILDTAKTYLAMGSDIFVIRHQQAGVPHFIASQ 125
Query: 121 AE-----VPVINAGDGSNQHPTQTLLDLYTIKKEFGR-------IDGLKIGLLGDLKYGR 168
+ V V+NAGDG ++HP+Q LLDL+TI +F + G KI ++GD+ + R
Sbjct: 126 MDRLQTGVKVLNAGDGQHEHPSQGLLDLFTICSQFAPDNPAIQCLQGKKIAVVGDILHSR 185
Query: 169 TVHSLAEALTFYDVELYLISPELLRMPRHIVEELREKGM-KVVETTTLEDVIGKLDVLYV 227
S +LT +++L P L +P+ + G K+ L+ + D++
Sbjct: 186 VARSNLWSLTTAGADVHLAGPPTL-LPKEFQQLTLAPGSGKLHCHWQLQPALEGADIVMT 244
Query: 228 TRIQKER-----FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPE-VD 279
R+QKER P +EY G LKV + ++++HP P R EI E +D
Sbjct: 245 LRLQKERMTAHLLPSLREYHHYFGITHDRLKVCQPG---VKVLHPGPVNRGVEISSELMD 301
Query: 280 NTKHAIYFRQVFNGVPVRMALLALV 304
+ ++ QV +GV +RMALL L+
Sbjct: 302 DPDISLIQDQVTSGVAIRMALLYLL 326
>pir||E81313 aspartate carbamoyltransferase (EC 2.1.3.2) Cj1098 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968532|emb|CAB73353.1| (AL139077) aspartate
carbamoyltransferase [Campylobacter jejuni]
Length = 295
Score = 144 bits (360), Expect = 1e-33
Identities = 105/303 (34%), Positives = 163/303 (53%), Gaps = 25/303 (8%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
R +I+ +DF+K +I + A L EK + + +GK + T+FFE STRT SFESA
Sbjct: 2 RHLITTKDFNKVEIMELFKEASDF---LDEKPRT-FLEGKSITTIFFENSTRTLSSFESA 57
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYC-DVIVIRHPKEGAARLAAEVAEVP 124
RLG V+ + S SS KGE+L DT ++ + IV+RH G + A+ P
Sbjct: 58 ARRLGARVLRL-DVSRSSSSKGETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCP 116
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEF-GRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
V+N GDG + HPTQ LLDL+TI F G ++G KI ++GD+K R S E L+ ++++
Sbjct: 117 VVNGGDGKHAHPTQALLDLFTIYNHFQGNVEGKKICIVGDIKNSRVAASNIELLSRFNLD 176
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLK 243
+ L++P H+ + + E++I D++ R Q ER ++ Y
Sbjct: 177 ITLVAPPHFMPNTHLKKHYKLD----------ENIIANSDIIMSLRTQTERH-NKTVYAS 225
Query: 244 VKGSYQVNL---KVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRM 298
+K Y + K L K K +L ++HP P R +I E+ + + + +QV NGV +RM
Sbjct: 226 LK-DYANDFCIQKSLVKDK-KLILLHPGPVNRNIDISDEMMSNERTLVLKQVKNGVAIRM 283
Query: 299 ALL 301
A+L
Sbjct: 284 AVL 286
>gb|AAF72727.1| (AF264709) aspartate transcarbamoylase [Enterococcus faecalis]
Length = 308
Score = 144 bits (359), Expect = 1e-33
Identities = 104/285 (36%), Positives = 152/285 (52%), Gaps = 24/285 (8%)
Query: 32 ELKEKGQLEYAKGKILAT-LFFEPSTRTRLSFESAMHRLGGAVIGFAEASTSSVKKGESL 90
E K+ + + + AT LFFE STRT SFE A +LG VI F EAS SSV+KGE+L
Sbjct: 33 EFKQGAKWHPEERQYFATNLFFENSTRTHKSFEVAEKKLGLEVIEF-EASRSSVQKGETL 91
Query: 91 RDTIKTVEQY-CDVIVIRHPKEGA--ARLAAEVAEVPVINAGDGSNQHPTQTLLDLYTIK 147
DT+ T+ DV VIRH KE + ++ + +IN GDGS QHPTQ LLDL TI
Sbjct: 92 YDTVLTMSAIGVDVAVIRHGKENYYDELIQSKTIQCSIINGGDGSGQHPTQCLLDLMTIY 151
Query: 148 KEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELYLISPELLRMPRHIVEELREKGM 207
+EFG +GLK+ ++GD+ + R S + L E+Y P EE +
Sbjct: 152 EEFGGFEGLKVAIVGDITHSRVAKSNMQLLNRLGAEIYFSGP----------EEWYDHQF 201
Query: 208 KVV-ETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVKGSYQVNLKVLEKAKDELR--- 263
V + L++++ K+DV+ + R+Q ER ++ + K Y + + + L+
Sbjct: 202 DVYGQYVPLDEIVEKVDVMMLLRVQHERHDGKESF--SKEGYHLEYGLTNERATRLQKHA 259
Query: 264 -IMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVL 305
IMHP P R E+ E+ + + Q+ NGV +RMA+L +L
Sbjct: 260 IIMHPAPVNRDVELADELVESLQSRIVAQMSNGVFMRMAILEAIL 304
>sp|P18186|OTCA_BACSU ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (OTCASE)
>gi|66493|pir||OWBS ornithine carbamoyltransferase (EC
2.1.3.3) - Bacillus subtilis >gi|39811|emb|CAA37444.1|
(X53360) argF protein (AA 1 - 319) [Bacillus subtilis]
>gi|408120|emb|CAA81542.1| (Z26919) ornithine
carbamoyltransferase [Bacillus subtilis]
>gi|2633462|emb|CAB12966.1| (Z99109) ornithine
carbamoyltransferase [Bacillus subtilis]
>gi|2633479|emb|CAB12982.1| (Z99110) ornithine
carbamoyltransferase [Bacillus subtilis]
Length = 319
Score = 140 bits (350), Expect = 2e-32
Identities = 101/310 (32%), Positives = 161/310 (51%), Gaps = 19/310 (6%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+D+++++D S+EDI +LA A ELK+ GK LA +F + STRTR+SFE+
Sbjct: 11 GKDLLTLKDLSEEDINALLAEAG----ELKQNKIQPIFHGKTLAMIFEKSSTRTRVSFEA 66
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
M +LGG+ + F + +GE++ DT K + Y D I+IR + A+ A++P
Sbjct: 67 GMAQLGGSAL-FLSQKDLQLGRGETVADTAKVLSGYVDAIMIRTFEHEKVEELAKEADIP 125
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VIN G HP Q L DL TIK+ G++ G+K+ +GD HSL ++
Sbjct: 126 VIN-GLTDKYHPCQALADLLTIKEIKGKLKGVKVAYIGD--GNNVAHSLMIGCAKMGCDI 182
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLED----VIGKLDVLY---VTRIQKERFPD 237
+ SP+ + E + ++ + TL D + DV+Y T + +E +
Sbjct: 183 SIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPIEAVKDADVIYSDVFTSMGQE--AE 240
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVP 295
EQE L V YQVN ++ AK + +H LP R +E+ E+ + ++ F+Q N +
Sbjct: 241 EQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHREEEVTAEIIDGPNSAVFQQAENRLH 300
Query: 296 VRMALLALVL 305
V+ ALL +L
Sbjct: 301 VQKALLKAIL 310
>gb|AAA37061.1| (M11242) CAD protein [Mesocricetus auratus]
Length = 152
Score = 138 bits (344), Expect = 8e-32
Identities = 72/149 (48%), Positives = 99/149 (66%)
Query: 158 IGLLGDLKYGRTVHSLAEALTFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLED 217
I ++GDLK+GRTVHSLA LT Y V L ++P LRMP + + + +G K E ++E+
Sbjct: 2 ITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPSVWDFVASRGTKQEEFESIEE 61
Query: 218 VIGKLDVLYVTRIQKERFPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPE 277
+ DVLY+TRIQKERF QEY G + + ++ +AK ++ +MHP+PRV+EI E
Sbjct: 62 ALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVE 121
Query: 278 VDNTKHAIYFRQVFNGVPVRMALLALVLG 306
VD+ A YFRQ NG+ +RMALLA VLG
Sbjct: 122 VDSDPRAAYFRQAENGMYIRMALLATVLG 150
>sp|O66726|PYRB_AQUAE ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433597|pir||B70337 aspartate
carbamoyltransferase catalytic chain - Aquifex aeolicus
>gi|2983068|gb|AAC06675.1| (AE000688) aspartate
carbamoyltransferase catalytic chain [Aquifex aeolicus]
Length = 291
Score = 136 bits (339), Expect = 3e-31
Identities = 109/309 (35%), Positives = 165/309 (53%), Gaps = 39/309 (12%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFF-EPSTRTRLSFES 64
R +IS D ++E++E +L A +E KE G+ E K A LFF EPSTRTRLSFE
Sbjct: 2 RSLISSLDLTREEVEEILKYA----KEFKE-GKEETIKAS--AVLFFSEPSTRTRLSFEK 54
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHP------KEGAARLA 117
A LG S SS KGES DT+KT E D +V R P KE L
Sbjct: 55 AARELGIETY-LVSGSESSTVKGESFFDTLKTFEGLGFDYVVFRVPFVFFPYKEIVKSL- 112
Query: 118 AEVAEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEAL 177
+ ++NAGDG++QHP+Q L+D +TIK+ FG + L++ +GD+K+ R S A L
Sbjct: 113 ----NLRLVNAGDGTHQHPSQGLIDFFTIKEHFGEVKDLRVLYVGDIKHSRVFRSGAPLL 168
Query: 178 TFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDV---IGKLDVLYVTRIQKER 234
+ ++ + P+ L +PR + +V + +DV I DV+ R+QKER
Sbjct: 169 NMFGAKIGVCGPKTL-IPRDV---------EVFKVDVFDDVDKGIDWADVVIWLRLQKER 218
Query: 235 FPDEQEYLKVKGSYQVNLKVLEKAKDELRI-MHPLP--RVDEIHPEVDNTKHAIYFRQVF 291
++ Y+ + SY + ++ +++++ MHP P R +I E+ T+ ++ QV
Sbjct: 219 --QKENYIPSESSYFKQFGLTKERFEKVKLYMHPGPVNRNVDIDHELVYTEKSLIQEQVK 276
Query: 292 NGVPVRMAL 300
NG+PVR A+
Sbjct: 277 NGIPVRKAI 285
>sp|Q9ZM81|PYRB_HELPJ ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433606|pir||H71944 aspartate
carbamoyltransferase catalytic chain - Helicobacter
pylori (strain J99) >gi|4154863|gb|AAD05915.1|
(AE001469) ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC
CHAIN [Helicobacter pylori J99]
Length = 307
Score = 134 bits (335), Expect = 9e-31
Identities = 112/323 (34%), Positives = 159/323 (48%), Gaps = 36/323 (11%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAE-------RLERELKEKGQLEYAKGKILATLFFE 53
M K R ++ D S ++I+ +L A + E +EK Q KI+ LFFE
Sbjct: 1 MPKKCRHLLQTSDLSLDEIKLLLNKASVYANDFNAVSLETREKMQ-----DKIIVALFFE 55
Query: 54 PSTRTRLSFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVE-QYCDVIVIRHPKEG 112
STRT SFE A RLG ++ TSS KGE+L DT K + D I+ RH
Sbjct: 56 NSTRTVSSFEIASLRLGAKIVKL-NMQTSSTSKGETLIDTFKNIHAMQPDAIITRHAFSS 114
Query: 113 AARLAAEVAEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRID---GLKIGLLGDLKYGRT 169
A AE ++ P+INAG G++ HPTQ LLDL T+ + FG ++ G KI +GD+K R
Sbjct: 115 APFKLAEFSQCPLINAGSGTSAHPTQALLDLLTLYRHFGSLENLKGKKIAFIGDVKNSRV 174
Query: 170 VHSLAEALTFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTR 229
+S + L +E+ L +P + +P + L+ T +E+ IG D+L R
Sbjct: 175 ANSNIKLLQRLGLEIMLCAPSSM-LP---ITPLK-------TTHNIEEAIGFADILMSLR 223
Query: 230 IQKER-----FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTK 282
Q ER F ++Y Q L+ K K E+ I+HP P R +I V K
Sbjct: 224 TQTERHNAPIFASLKDYGNAYCITQKRLETHAKNK-EVIILHPGPVHRDIDIESAVLEDK 282
Query: 283 HAIYFRQVFNGVPVRMALLALVL 305
+ QV NGV +RMA+L +L
Sbjct: 283 RSKVLEQVKNGVAMRMAVLEFLL 305
>gb|AAB99909.1| (AF018428) aspartate carbamoyltransferase; ACTase [Helicobacter
pylori]
Length = 307
Score = 134 bits (333), Expect = 2e-30
Identities = 112/323 (34%), Positives = 157/323 (47%), Gaps = 36/323 (11%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAE-------RLERELKEKGQLEYAKGKILATLFFE 53
M K R ++ D S ++I+ +L A + E KEK KI+ LFFE
Sbjct: 1 MPKKCRHLLQTSDLSLDEIKLLLEKASVYANDFNAVSLETKEK-----MHNKIIVALFFE 55
Query: 54 PSTRTRLSFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVE-QYCDVIVIRHPKEG 112
STRT SFE A RLG ++ TSS KGE+L DT K + D I+ RH
Sbjct: 56 NSTRTVSSFEIASLRLGAKIVKL-NMQTSSTSKGETLTDTFKNIHAMQPDAIITRHAFSS 114
Query: 113 AARLAAEVAEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRID---GLKIGLLGDLKYGRT 169
A AE ++ P+INAG G++ HPTQ LLDL T+ + FG ++ G KI +GD+K R
Sbjct: 115 APFKLAEFSQCPLINAGSGTSAHPTQALLDLLTLYQHFGGLENLKGKKIAFIGDVKNSRV 174
Query: 170 VHSLAEALTFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTR 229
+S + L +E+ L +P + +P + LR T +E+ I D+L R
Sbjct: 175 ANSNIKLLQRLGLEIMLCAPSSM-LP---ITPLR-------TTHNIEEAIAFADILMSLR 223
Query: 230 IQKER-----FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTK 282
Q ER F ++Y Q L+ K K E+ I+HP P R +I V K
Sbjct: 224 TQTERHNAPIFASLKDYGNAYCITQKRLETHAKNK-EVIILHPGPVHRDIDIESAVLEDK 282
Query: 283 HAIYFRQVFNGVPVRMALLALVL 305
+ QV NGV +RMA+L +L
Sbjct: 283 RSKVLEQVKNGVAMRMAVLEFLL 305
>sp|O25716|PYRB_HELPY ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE TRANSCARBAMYLASE)
(ATCASE) >gi|7433607|pir||D64655 aspartate
transcarbamoylase - Helicobacter pylori (strain 26695)
>gi|2314233|gb|AAD08128.1| (AE000615) aspartate
transcarbamoylase (pyrB) [Helicobacter pylori 26695]
Length = 307
Score = 133 bits (331), Expect = 3e-30
Identities = 110/323 (34%), Positives = 155/323 (47%), Gaps = 36/323 (11%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAE-------RLERELKEKGQLEYAKGKILATLFFE 53
M K R ++ D S ++I+ +L A + E KEK KI+ LFFE
Sbjct: 1 MPKKCRHLLQTSDLSLDEIKLLLEKASVYANDFNAVSLETKEK-----MHNKIIVALFFE 55
Query: 54 PSTRTRLSFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVE-QYCDVIVIRHPKEG 112
STRT SFE A RLG ++ TSS KGE+L DT K + D I+ RH
Sbjct: 56 NSTRTVSSFEIASLRLGAKIVKL-NMQTSSASKGETLTDTFKNIHAMQPDAIITRHAFSS 114
Query: 113 AARLAAEVAEVPVINAGDGSNQHPTQTLLDLYTIKKEFGRID---GLKIGLLGDLKYGRT 169
A AE ++ P+INAG G + HPTQ LLDL T+ + FG ++ G KI +GD+K R
Sbjct: 115 APFKLAEFSQCPLINAGSGVSAHPTQALLDLLTLYQHFGSLENLKGKKIAFIGDVKNSRV 174
Query: 170 VHSLAEALTFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTR 229
+S + L +E+ L +P + +P + + T +E+ I D+L R
Sbjct: 175 ANSNIKLLQRLGLEIMLCAPSSM-LP----------SVSLKTTHNVEEAIAFADILMSLR 223
Query: 230 IQKER-----FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTK 282
Q ER F ++Y Q LK K K E+ I+HP P R +I V +
Sbjct: 224 TQTERHNTPIFASLKDYGNAYCITQQRLKAHAKNK-EVIILHPGPVHRDIDIESAVLEDE 282
Query: 283 HAIYFRQVFNGVPVRMALLALVL 305
+ QV NGV +RMA+L +L
Sbjct: 283 RSKVLEQVKNGVAMRMAVLEFLL 305
>pir||T45077 ornithine carbamoyltransferase [imported] - Pyrococcus furiosus
>gi|1430923|emb|CAA67609.1| (X99225) ornithine
carbamoyltransferase [Pyrococcus furiosus]
Length = 314
Score = 131 bits (326), Expect = 1e-29
Identities = 95/310 (30%), Positives = 159/310 (50%), Gaps = 10/310 (3%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
GRD++ ++D++ E+I T+L TA+ + K +GK LA +F +PSTRTR+SFE
Sbjct: 7 GRDLLCLQDYTAEEIWTILETAKMFKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVSFEV 66
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM LGG + + A +++GE++ DT + + +Y D I+ R A+ A VP
Sbjct: 67 AMAHLGGHAL-YLNAQDLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYATVP 125
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VIN G HP Q L D TI ++ G I G+K+ +GD HSL A T ++
Sbjct: 126 VIN-GLSDFSHPCQALADYMTIWEKKGTIKGVKVVYVGD--GNNVAHSLMIAGTKLGADV 182
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLED---VIGKLDVLYV-TRIQKERFPDEQE 240
+ +PE +++ + + L D + DV+Y + + +E
Sbjct: 183 VVATPEGYEPDEKVIKWAEQNAAESGSFELLHDPVKAVKDADVIYTDVWASMGQEAEAEE 242
Query: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRM 298
K+ +QVN +++ AK + MH LP R +E+ +V ++ +++ + Q N + +
Sbjct: 243 RRKIFRPFQVNKDLVKHAKPDYMFMHCLPAHRGEEVTDDVIDSPNSVVWDQAENRLHAQK 302
Query: 299 ALLALVLGVI 308
A+LALV+G I
Sbjct: 303 AVLALVMGGI 312
>emb|CAA28502.1| (X04813) CAD protein (AA 1 - 2236) [Drosophila melanogaster]
Length = 2236
Score = 131 bits (325), Expect = 1e-29
Identities = 92/308 (29%), Positives = 155/308 (49%), Gaps = 15/308 (4%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
G+ ++++ F+K+ + + A+ L+ + + GKI+A++F+E STRT SF +
Sbjct: 1922 GKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVALLPGKIMASVFYEVSTRTPCSFAA 1981
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM RLGG VI + TSSVKKGE+ R + ++RHP GA +A
Sbjct: 1982 AMLRLGGRVISM-DNITSSVKKGETWRTASRLCPAMPTSWLLRHPSPGA--VARTTFSQS 2038
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
++ +H Q LLD++T + G ++GL I + R AL +
Sbjct: 2039 RLSMPACRREHSHQALLDIFTDPRVGGTVNGLTITMW------RLEERTDRALAGPPADP 2092
Query: 185 YLISPEL------LRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE 238
P + L+MP +V+ + ++G+K + L++ + +ERF +
Sbjct: 2093 VQCEPAVMWRRDSLQMPDEVVQFVHQRGVKQLFARDLKECAARHGCALHDSHSRERFDNV 2152
Query: 239 QEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVRM 298
++Y K G + + + +AK ++HPLPR++EI E+D A YFRQ G+ +RM
Sbjct: 2153 EDYEKCCGHLVLTPEHMMRAKKRSIVLHPLPRLNEISREIDLDPRAAYFRQAEYGMYIRM 2212
Query: 299 ALLALVLG 306
ALLA+V+G
Sbjct: 2213 ALLAMVVG 2220
>emb|CAA71345.1| (Y10300) aspartate carbamoyltransferase with fused catalytic and
regulatory chains [Thermotoga maritima]
Length = 525
Score = 130 bits (323), Expect = 2e-29
Identities = 104/336 (30%), Positives = 172/336 (50%), Gaps = 30/336 (8%)
Query: 2 DWKGRDVISIRDFSKEDIETVLATAERLEREL---KEKGQLEYAKGKI-LATLFFEPSTR 57
D+ GR + I D S E+ + L++ ++ K + + +F EPSTR
Sbjct: 4 DFLGRTLAVIEDLSVEEQMFLYEKTRELKQRWYSGEDVSDFRIKKRNVGIYIVFVEPSTR 63
Query: 58 TRLSFESA--MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCD--VIVIRHPKEGA 113
T+ SF +A H + ++ SS K ES DT + Y D + V+R EG
Sbjct: 64 TKESFINAAKFHSGPNVKVNVFDSEHSSFNKQESYTDTFSMLTGYSDYSIFVVRTRLEGV 123
Query: 114 ARLA----AEVA-----EVP-VINAGDGSNQHPTQTLLDLYTIKKEFGRIDG-LKIGLLG 162
RL +E A EVP INAGDG ++HPTQ LLD YT ++ G + + + L+G
Sbjct: 124 CRLLERRISEFASRNGIEVPSFINAGDGKHEHPTQELLDEYTFLEQNGFDNSFIHVALVG 183
Query: 163 DLKYGRTVHSLAEAL-TFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGK 221
DL +GRTVHS L F +V++ L++PE L MP H VE++++ G +V +++ + + +
Sbjct: 184 DLLHGRTVHSKVNGLKIFKNVKVDLVAPEELMMPEHYVEKMKKNGFEVRIFSSIREYLDQ 243
Query: 222 LDVL---YVTRIQKERFPDE--QEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHP 276
DV Y TR+Q ER ++ ++ ++ + + L+ + ++ HPLPR +++P
Sbjct: 244 KDVAKIWYFTRLQLERMGEDILEKVHVLREAVTFKKEYLDALPEGVKFYHPLPR-HKVYP 302
Query: 277 EVDNTKHAI----YFRQVFNGVPVRMALLALVLGVI 308
+ N + + Q NG VR+ LL++ G +
Sbjct: 303 TIPNFLDTLPLNGWETQARNGYWVRIVLLSMFGGAL 338
>sp|P96111|PYRB_THEMA PYRBI PROTEIN [INCLUDES: ASPARTATE CARBAMOYLTRANSFERASE (ASPARTATE
TRANSCARBAMYLASE) (ATCASE); ASPARTATE
CARBAMOYLTRANSFERASE REGULATORY REGION]
>gi|7462060|pir||B72231 aspartate carbamoyltransferase,
catalytic and regulatory chains - Thermotoga maritima
(strain MSB8) >gi|4982215|gb|AAD36709.1|AE001806_19
(AE001806) aspartate carbamoyltransferase, catalytic and
regulatory chains [Thermotoga maritima]
Length = 527
Score = 130 bits (323), Expect = 2e-29
Identities = 104/336 (30%), Positives = 172/336 (50%), Gaps = 30/336 (8%)
Query: 2 DWKGRDVISIRDFSKEDIETVLATAERLEREL---KEKGQLEYAKGKI-LATLFFEPSTR 57
D+ GR + I D S E+ + L++ ++ K + + +F EPSTR
Sbjct: 4 DFLGRTLAVIEDLSVEEQMFLYEKTRELKQRWYSGEDVSDFRIKKRNVGIYIVFVEPSTR 63
Query: 58 TRLSFESA--MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCD--VIVIRHPKEGA 113
T+ SF +A H + ++ SS K ES DT + Y D + V+R EG
Sbjct: 64 TKESFINAAKFHSGPNVKVNVFDSEHSSFNKQESYTDTFSMLTGYSDYSIFVVRTRLEGV 123
Query: 114 ARLA----AEVA-----EVP-VINAGDGSNQHPTQTLLDLYTIKKEFGRIDG-LKIGLLG 162
RL +E A EVP INAGDG ++HPTQ LLD YT ++ G + + + L+G
Sbjct: 124 CRLLERRISEFASRNGIEVPSFINAGDGKHEHPTQELLDEYTFLEQNGFDNSFIHVALVG 183
Query: 163 DLKYGRTVHSLAEAL-TFYDVELYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGK 221
DL +GRTVHS L F +V++ L++PE L MP H VE++++ G +V +++ + + +
Sbjct: 184 DLLHGRTVHSKVNGLKIFKNVKVDLVAPEELMMPEHYVEKMKKNGFEVRIFSSIREYLDQ 243
Query: 222 LDVL---YVTRIQKERFPDE--QEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHP 276
DV Y TR+Q ER ++ ++ ++ + + L+ + ++ HPLPR +++P
Sbjct: 244 KDVAKIWYFTRLQLERMGEDILEKVHVLREAVTFKKEYLDALPEGVKFYHPLPR-HKVYP 302
Query: 277 EVDNTKHAI----YFRQVFNGVPVRMALLALVLGVI 308
+ N + + Q NG VR+ LL++ G +
Sbjct: 303 TIPNFLDTLPLNGWETQARNGYWVRIVLLSMFGGAL 338
>sp|O93656|OTC_PYRAB ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|7433600|pir||G75041
ornithine carbamoyltransferase (argf) PAB1502 -
Pyrococcus abyssi (strain Orsay)
>gi|5458741|emb|CAB50228.1| (AJ248287) ornithine
carbamoyltransferase (argF) [Pyrococcus abyssi]
Length = 317
Score = 129 bits (322), Expect = 3e-29
Identities = 95/310 (30%), Positives = 158/310 (50%), Gaps = 11/310 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGRD++ ++D++ E+I T+L TA+ L+ K +GK LA +F +PSTRTR+SFE
Sbjct: 6 KGRDLLCLQDYTPEEIWTILETAKMLKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVSFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
AM LGG + + A +++GE++ DT + + +Y D I+ R A+ A V
Sbjct: 66 VAMAHLGGHAL-YLNAQDLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYASV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PVIN G HP Q L D TI ++ G I G+K+ +GD HSL A T +
Sbjct: 125 PVIN-GLSDFSHPCQALADYMTIWEKKGTIKGVKVVYVGD--GNNVAHSLMIAGTKLGAD 181
Query: 184 LYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDE 238
+ + +PE ++ + E G + DV+Y + +
Sbjct: 182 VVVATPEGYEPDEKVIKWAEQNAAESGGSFELLHDPVKAVKDADVIYTDVWASMGQEAEA 241
Query: 239 QEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPV 296
+E K+ +QVN +++ AK + MH LP R +E+ +V ++ +++ + + N +
Sbjct: 242 EERRKIFRPFQVNKDLVKHAKPDYMFMHCLPAHRGEEVTDDVIDSPNSVVWDEAENRLHA 301
Query: 297 RMALLALVLG 306
+ A+LAL+LG
Sbjct: 302 QKAVLALLLG 311
>sp|O58457|OTC_PYRHO ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|7433591|pir||G71119
probable ornithine carbamoyltransferase - Pyrococcus
horikoshii >gi|3257134|dbj|BAA29817.1| (AP000003) 317aa
long hypothetical ornithine carbamoyltransferase
[Pyrococcus horikoshii]
Length = 317
Score = 129 bits (321), Expect = 4e-29
Identities = 96/311 (30%), Positives = 160/311 (50%), Gaps = 13/311 (4%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGRD++ ++D++ E+I T+L TA+ + K +GK LA +F +PSTRTR+SFE
Sbjct: 6 KGRDLLCLQDYTPEEIWTILETAKMFKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVSFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
AM LGG + + A +++GE++ DT + + +Y D I+ R A+ A V
Sbjct: 66 VAMAHLGGHAL-YLNAQDLQLRRGETIADTARVLSRYVDAIMARVYAHKDVEDLAKYASV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTV-HSLAEALTFYDV 182
PVIN G HP Q L D TI ++ G I G+K+ +GD G V HSL A T
Sbjct: 125 PVIN-GLSDFSHPCQALADYMTIWEKKGTIKGVKVVYVGD---GNNVCHSLMIAGTKLGA 180
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPD 237
++ + +PE + ++ + E G + DV+Y + +
Sbjct: 181 DVVVATPEGYEPDKKVIKWAEQNAAESGGSFELLHDPVKAVKDADVIYTDVWASMGQEAE 240
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVP 295
+E K+ +QVN +++ AK + MH LP R +E+ +V ++ +++ + + N +
Sbjct: 241 AEERRKIFRPFQVNKDLVKHAKSDYMFMHCLPAHRGEEVTDDVIDSPNSVVWDEAENRLH 300
Query: 296 VRMALLALVLG 306
+ A+LAL+LG
Sbjct: 301 AQKAVLALLLG 311
>gi|11498854 ornithine carbamoyltransferase (argF) [Archaeoglobus fulgidus]
>gi|3183096|sp|O29013|OTC_ARCFU ORNITHINE
CARBAMOYLTRANSFERASE (OTCASE) >gi|7433595|pir||F69406
ornithine carbamoyltransferase (argF) homolog -
Archaeoglobus fulgidus >gi|2649323|gb|AAB89987.1|
(AE001017) ornithine carbamoyltransferase (argF)
[Archaeoglobus fulgidus]
Length = 307
Score = 129 bits (320), Expect = 5e-29
Identities = 95/306 (31%), Positives = 162/306 (52%), Gaps = 11/306 (3%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
+ ++S+ D K+++ +L AE+L+ E + +Y K K LA +F PSTRTR+SFE A
Sbjct: 2 KHLLSMADLEKDELFEILKLAEKLKEERYKGVVTDYLKNKSLAMIFELPSTRTRVSFEVA 61
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
M LGG + + + +GE ++DT + + +Y +++R + A + VPV
Sbjct: 62 MTDLGGHAL-YLGWDELQLGRGEPIKDTARVLSRYVHAVMMRVREHSTIEEFARYSTVPV 120
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELY 185
IN G + +HP Q + DL TI + G + + +GD LA ALT +++
Sbjct: 121 IN-GLSNLEHPCQVIADLLTIYEYRGDFKDVTLAWVGDGNNVCNSMILAAALT--GMKMV 177
Query: 186 LISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYV---TRIQKERFPDEQEYL 242
+ +PE IV++ E G K+ ++ + + DV+Y T + +E +++ L
Sbjct: 178 ISTPENYDPNPEIVKKAEEMGAKLRFVRDPKEAVKEADVIYTDVWTSMGQE--AEKEARL 235
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
K YQV+ ++L+ +KD++ +MH LP R +EI EV KH+I F Q N + + A+
Sbjct: 236 KAFQPYQVSDELLKFSKDDVVVMHCLPAHRGEEITDEVMEGKHSIVFDQAENRLHAQKAI 295
Query: 301 LALVLG 306
L +LG
Sbjct: 296 LLKLLG 301
>pir||H82583 aspartate carbamoyltransferase XF2226 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107375|gb|AAF85025.1|AE004035_4 (AE004035)
aspartate carbamoyltransferase [Xylella fastidiosa]
Length = 322
Score = 129 bits (320), Expect = 5e-29
Identities = 109/316 (34%), Positives = 160/316 (50%), Gaps = 28/316 (8%)
Query: 6 RDVISIRDFSKEDIETVL-ATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
R ++++ S++ + +L A+ + G+ G + TLFFEPSTRTR SF
Sbjct: 18 RHLLTLEGLSRDTLLQLLDCAAQNCALGVDPMGKRNVLAGMAVCTLFFEPSTRTRHSFHL 77
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKE-GAARLAAEVAE 122
A RLG V+ F +AS SS KGES DT+K +E ++RHP+E A+LAA V E
Sbjct: 78 AAQRLGADVLNF-DASMSSTSKGESACDTLKNLEAMGVRGFIVRHPEEIVIAQLAAVVGE 136
Query: 123 VPV-INAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKYGRTVHSLAEAL-TF 179
V INAG G + HPTQ LLD+ T+ + G LK+ +GD+K+ R S AL T
Sbjct: 137 GTVLINAGAGRSTHPTQALLDMLTLCQAKGNDFSKLKLLFVGDIKHSRVARSNLHALRTL 196
Query: 180 YDVELYLISPELLRMPRHIVEELREKGM--KVVETTTLEDVIGKLDVLYVTRIQKERF-- 235
++ + P L L G+ V + + ++ +DVL + R+Q+ER
Sbjct: 197 GAGQIRVCGPTAL---------LPHDGLLSGCVVSQDFDAMLEGVDVLMMLRLQRERMEE 247
Query: 236 ---PDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQV 290
P + Y +Y + L +A + ++HP P R EI EV + + RQ
Sbjct: 248 GLVPSLEHY---HANYGLTAARLARAAPDAVVLHPGPINRGVEITDEVADGPQSWILRQA 304
Query: 291 FNGVPVRMALLALVLG 306
NGV VRMA+L +LG
Sbjct: 305 SNGVMVRMAVLETLLG 320
>pdb|1A1S| Ornithine Carbamoyltransferase From Pyrococcus Furiosus
Length = 314
Score = 127 bits (317), Expect = 1e-28
Identities = 95/311 (30%), Positives = 157/311 (49%), Gaps = 11/311 (3%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
GRD++ ++D++ E+I T+L TA+ + K +GK LA +F +PSTRTR+SFE
Sbjct: 6 GRDLLCLQDYTAEEIWTILETAKMFKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVSFEV 65
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM LGG + + A +++GE++ DT + + +Y D I+ R A+ A VP
Sbjct: 66 AMAHLGGHAL-YLNAQDLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYATVP 124
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VIN G HP Q L D TI ++ G I G+K+ +GD HSL A T ++
Sbjct: 125 VIN-GLSDFSHPCQALADYMTIWEKKGTIKGVKVVYVGD--GNNVAHSLMIAGTKLGADV 181
Query: 185 YLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDEQ 239
+ +PE ++ + E G + DV+Y + + +
Sbjct: 182 VVATPEGYEPDEKVIKWAEQNAAESGGSFELLHDPVKAVKDADVIYTDVWASMGQEAEAE 241
Query: 240 EYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVR 297
E K+ +QVN +++ AK + MH LP R +E+ +V ++ +++ + Q N + +
Sbjct: 242 ERRKIFRPFQVNKDLVKHAKPDYMFMHCLPAHRGEEVTDDVIDSPNSVVWDQAENRLHAQ 301
Query: 298 MALLALVLGVI 308
A+LALV+G I
Sbjct: 302 KAVLALVMGGI 312
>sp|Q51742|OTC_PYRFU ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|3341473|emb|CAA73260.1|
(Y12727) ornithine carbamoyltransferase [Pyrococcus
furiosus]
Length = 315
Score = 127 bits (316), Expect = 2e-28
Identities = 94/311 (30%), Positives = 159/311 (50%), Gaps = 11/311 (3%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
GRD++ ++D++ E+I T+L TA+ + K +GK LA +F +PSTRTR+SFE
Sbjct: 7 GRDLLCLQDYTAEEIWTILETAKMFKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVSFEV 66
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM LGG + + A +++GE++ DT + + +Y D I+ R A+ A VP
Sbjct: 67 AMAHLGGHAL-YLNAQDLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYATVP 125
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VIN G HP Q L D TI ++ G I G+K+ +GD HSL A T ++
Sbjct: 126 VIN-GLSDFSHPCQALADYMTIWEKKGTIKGVKVVYVGD--GNNVAHSLMIAGTKLGADV 182
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTL----EDVIGKLDVLYV-TRIQKERFPDEQ 239
+ +PE +++ + + + L + DV+Y + + +
Sbjct: 183 VVATPEGYEPDEKVIKWAEQNAAERSGSFELLHDPVKAVKDADVIYTDVWASMGQEAEAE 242
Query: 240 EYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVR 297
E K+ +QVN +++ AK + MH LP R +E+ +V ++ +++ + Q N + +
Sbjct: 243 ERRKIFRPFQVNKDLVKHAKPDYMFMHCLPAHRGEEVTDDVIDSPNSVVWDQAENRLHAQ 302
Query: 298 MALLALVLGVI 308
A+LALV+G I
Sbjct: 303 KAVLALVMGGI 313
>sp|P96108|OTCA_THEMA ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (OTCASE)
>gi|7433604|pir||C72294 ornithine carbamoyltransferase,
anabolic - Thermotoga maritima (strain MSB8)
>gi|1806543|emb|CAA71670.1| (Y10661) ornithine
carbamoyltransferase [Thermotoga maritima]
>gi|4981642|gb|AAD36173.1|AE001769_3 (AE001769)
ornithine carbamoyltransferase, anabolic [Thermotoga
maritima]
Length = 313
Score = 126 bits (314), Expect = 3e-28
Identities = 101/303 (33%), Positives = 148/303 (48%), Gaps = 25/303 (8%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGR ++++ DFS E+I +L +++++ E + K + E KG LA +F + STRTRL+FE
Sbjct: 6 KGRSLLTLLDFSPEEIRYLLDISKQVKMENRSKLRTERFKGMTLAMIFEKRSTRTRLAFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+A GG I F + + ESL DT + + + D I+ R K+ AE + V
Sbjct: 66 TAFAEEGGHPI-FLSPNDIHLGAKESLEDTARVLGRMVDAIMFRGYKQETVEKLAEYSGV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV N G HPTQ L DL TI++ FGR+ G+K+ +GD + SL A +
Sbjct: 125 PVYN-GLTDEFHPTQALADLMTIEENFGRLKGVKVVFMGDTR-NNVATSLMIACAKMGMN 182
Query: 184 LYLISPELLRMPRHIV-----EELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPD- 237
PE L+ PR V E ++E V T+ LE+ + DV+Y D
Sbjct: 183 FVACGPEELK-PRSDVFKRCQEIVKETDGSVSFTSNLEEALAGADVVYTDVWASMGEEDK 241
Query: 238 EQEYLKVKGSYQVNLKVLE-KAKDELRIMHPLPRV--------------DEIHPEVDNTK 282
E+E + + YQVN +V+E K E MH LP V + E +N K
Sbjct: 242 EKERMALLKPYQVNERVMEMTGKSETIFMHCLPAVKGQEVTYEVIEGKQSRVWDEAENRK 301
Query: 283 HAI 285
H I
Sbjct: 302 HTI 304
>gb|AAD09004.1| (AF083209) ornithine carbamoyltransferase [Pyrococcus abyssi]
Length = 320
Score = 126 bits (314), Expect = 3e-28
Identities = 95/310 (30%), Positives = 156/310 (49%), Gaps = 11/310 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGRD++ ++D++ E+I T+L TA+ L+ K +GK LA +F +PSTRTR+ FE
Sbjct: 6 KGRDLLCLQDYTPEEIWTILETAKMLKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVRFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
AM LGG + + A +++GE++ DT + + +Y D I+ R A+ A V
Sbjct: 66 VAMAHLGGHGL-YLNAQDLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYASV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PVIN G HP Q L D TI ++ G I G+K+ +GD HSL A T +
Sbjct: 125 PVIN-GLSDFSHPCQALADYMTIWEKKGTIKGVKVIYVGD--GNNVAHSLMIAGTKLGAD 181
Query: 184 LYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDE 238
+ + +PE ++ E E G + DV+Y + +
Sbjct: 182 VVVATPEGYEPDEKVIKWADENAAESGGSFELLHDPVKAVKDADVIYTDVWASMGQEAEA 241
Query: 239 QEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPV 296
+E K+ +QVN +++ AK MH LP R +E+ +V ++ +++ + + N +
Sbjct: 242 EERRKIFRPFQVNKDLVKHAKPSYMFMHCLPAHRGEEVTDDVIDSPNSVVWDEAENRLHA 301
Query: 297 RMALLALVLG 306
+ A+LAL+LG
Sbjct: 302 QKAVLALLLG 311
>dbj|BAB06613.1| (AP001517) ornithine carbamoyltransferase [Bacillus halodurans]
Length = 319
Score = 126 bits (314), Expect = 3e-28
Identities = 96/312 (30%), Positives = 157/312 (49%), Gaps = 14/312 (4%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGRD++++ D++ E+++ +L A L+++ K Y GK L +F STRTR+SFE
Sbjct: 12 KGRDLLTLLDYTPEEVQQLLTQALELKQKAKNGEPTPYLTGKSLGMIFENASTRTRVSFE 71
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
M +LGG + F + +GE ++DT + +Y D I+IR + A A V
Sbjct: 72 VGMTQLGGHAL-FLSPKDLQIGRGEPIKDTANVLSRYVDAIMIRTNSHESVEELAHYATV 130
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTV-HSLAEALTFYDV 182
PVINA + HP Q L D TI ++ + G K+ +GD G V HSL +
Sbjct: 131 PVINALTDA-YHPCQALADALTILEKKETLIGKKLAYIGD---GNNVCHSLLAIGAKTGM 186
Query: 183 ELYLISPELLRMPRHI----VEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE 238
++ + +P+ + + I E +E G +V+TT + D +Y + E
Sbjct: 187 DVTVATPKGYEVDQEIFQRATEAAKETGATLVQTTNPQVAAENADAIYTDVWASMGYEAE 246
Query: 239 Q-EYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVP 295
Q E +V YQVN ++L AK ++ +H LP R +E+ V + H+ + Q N +
Sbjct: 247 QSEREEVFQPYQVNDQLLTLAKKDVSFLHCLPAHRGEEVTASVIDGPHSAIYDQAENRLH 306
Query: 296 VRMALL-ALVLG 306
+ A+L AL++G
Sbjct: 307 AQKAVLTALLIG 318
>sp|Q55497|OTCA_SYNY3 ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (OTCASE)
>gi|7433594|pir||S76000 hypothetical protein -
Synechocystis sp. (strain PCC 6803)
>gi|1001360|dbj|BAA10847.1| (D64006) ornithine
carbamoyltransferase chain f [Synechocystis sp.]
Length = 308
Score = 124 bits (309), Expect = 1e-27
Identities = 94/312 (30%), Positives = 165/312 (52%), Gaps = 19/312 (6%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
GRD+++I D + E+++++L A L+ G L+ KIL LF++ STRTR+SF +
Sbjct: 8 GRDLLAIADLTIEEMKSLLQLAADLK-----SGVLKPHCRKILGLLFYKASTRTRVSFTA 62
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM++LGG V+ S + V +GE ++DT + +++Y D++ +R K+ + A+ A++P
Sbjct: 63 AMYQLGGQVLDL-NPSVTQVGRGEPIQDTARVLDRYIDILAVRTFKQTDLQTFADHAKMP 121
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
+INA +HP Q L DL TIK+ FG+++GL + LGD HSL + +
Sbjct: 122 IINA-LSDLEHPCQILADLQTIKECFGKLEGLTVTYLGD--GNNVAHSLILGGVMMGMTV 178
Query: 185 YLISPELLRMPRHIVEELRE---KGMKVVETTTLEDVIGKLDVLYV---TRIQKERFPDE 238
+ +P+ IV++ ++ G KV T + +LY + +E D
Sbjct: 179 RVATPKNYEPLAEIVQQAQQIAAPGGKVELTDDPKAAAQGSHILYTDVWASMGQEDLADS 238
Query: 239 QEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPV 296
+ + + YQ+N ++L A E ++H LP R +EI V + + Q N +
Sbjct: 239 R--IPIFQPYQINQELLALADPEAIVLHCLPAHRGEEITDAVMEGPQSRLWDQAENRMHA 296
Query: 297 RMALLALVLGVI 308
+ AL+ +LG++
Sbjct: 297 QKALMVALLGLV 308
>emb|CAB89871.1| (AJ132624) aspartate transcarbamoylase [Lactococcus lactis]
Length = 310
Score = 123 bits (306), Expect = 2e-27
Identities = 96/296 (32%), Positives = 142/296 (47%), Gaps = 21/296 (7%)
Query: 19 IETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMHRLGGAVIGFAE 78
I+ V+ +R K + + LFFE STRT SF A +LG V+ F +
Sbjct: 21 IDEVMGLIKRASAFKAGKADFALDEQTFASNLFFENSTRTHHSFHIAERKLGLDVLEF-D 79
Query: 79 ASTSSVKKGESLRDTIKTVEQY-CDVIVIRHPKEGAAR--LAAEVAEVPVINAGDGSNQH 135
A SS+ KGE+L DT+ T++ D+ VIR E + ++ ++N GDGS QH
Sbjct: 80 AQASSISKGETLYDTVLTLDALGVDICVIRSGVEHYYEELVNSDNIHCAIVNGGDGSGQH 139
Query: 136 PTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVELYLISPELLRMP 195
P+Q LLDL TI +EFG+ +GLKI + GDL + R S L LY P
Sbjct: 140 PSQCLLDLMTIYEEFGKFEGLKIAISGDLTHSRVAKSNMMMLQKLGARLYFTGP-----A 194
Query: 196 RHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQEYLKVKGSYQVNLKVL 255
EE + G L+ ++ +LDV + R+Q ER + + K Y + +
Sbjct: 195 AWYSEEFDDYG----HYANLDRILPELDVHMLLRVQHERHDSGESF--SKEGYHTHFGLT 248
Query: 256 EKAKDELR----IMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVL 305
++ L+ IMHP P R EI + + + +Q+ NGV RMA+L +L
Sbjct: 249 QERAKMLKPTAIIMHPAPVNRDVEIADSLVESPQSRIVQQMSNGVYTRMAILEAIL 304
>gb|AAC36050.1| (AF030524) ornithine carbamoyltransferase; OCT [Nostoc PCC73102]
Length = 306
Score = 120 bits (297), Expect = 3e-26
Identities = 90/308 (29%), Positives = 152/308 (49%), Gaps = 15/308 (4%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
GRD++S+ D S +++ +L A +L+ + QL+ K+L LF + STRTR+SF
Sbjct: 6 GRDLLSLADISSTELQELLQLATQLKSQ-----QLKLQCNKVLGLLFSKASTRTRVSFTV 60
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
AM++LGG VI + + V +GE L+DT + +++Y D++ IR + A A++P
Sbjct: 61 AMYQLGGQVIDL-NPNVTQVSRGEPLQDTARVLDRYLDILAIRTFAQQDLETFAHYAKIP 119
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VINA + +HP Q L DL TI++ F + GL + +GD +SL + +
Sbjct: 120 VINALTDA-EHPCQVLADLLTIQESFNTLAGLTLTYVGD--GNNMANSLMLGCALVGMNV 176
Query: 185 YLISPELLRMPRHIVEELREKGMKVVETTTLED--VIGKLDVLYVTRI--QKERFPDEQE 240
+ +P+ IVE+ R E D + K + T + + +
Sbjct: 177 RIATPDGYEPDSQIVEQARAIANNKTEVLLTHDPELAAKGSTVLYTDVWASMGQETEADN 236
Query: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRM 298
+ + YQ++ ++L A E ++H LP R +EI V + + Q N + +
Sbjct: 237 SMPIFQPYQISEQLLSLAAPEAIVLHCLPAHRGEEITEAVIEGSQSRVWEQAENRLHAQK 296
Query: 299 ALLALVLG 306
ALLA +LG
Sbjct: 297 ALLASILG 304
>sp|Q58291|OTC_METJA ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|2129172|pir||A64410
ornithine carbamoyltransferase (EC 2.1.3.3) -
Methanococcus jannaschii >gi|1592314|gb|AAB98885.1|
(U67532) ornithine carbamoyltransferase (argF)
[Methanococcus jannaschii]
Length = 305
Score = 116 bits (289), Expect = 2e-25
Identities = 94/300 (31%), Positives = 154/300 (51%), Gaps = 18/300 (6%)
Query: 15 SKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMHRLGGAVI 74
S+ED+ ++ ++ ++ ++ +GK +A LF +PSTRTR+SF+ A++ LGG +
Sbjct: 10 SREDVLKIIEYGIYFKKNRRKHEKI--LEGKSVAILFEKPSTRTRMSFDIAVYELGGHPL 67
Query: 75 GFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPVINAGDGSNQ 134
+ + K ES++DT K + +Y D IV R K A+ + VPVINA
Sbjct: 68 -IMNQNEIHLGKKESIKDTAKVMGRYVDTIVARVYKHRHLEEMAKYSSVPVINA-LSDLA 125
Query: 135 HPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTV-HSLAEALTFYDVELYLISPELLR 193
HP Q L DL TIK+ G+ GLKI LGD G V +SL ++ Y+ +P+
Sbjct: 126 HPCQILADLMTIKEYKGKFKGLKIAYLGD---GNNVCNSLILGSALVGMDTYVGTPKGYE 182
Query: 194 MPRHIVEELRE------KGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDEQEYLKVKG 246
+V + +E +G + +E DVLY I D++E LK+
Sbjct: 183 PNAKVVLKAKEIINNYGEGSLTLTNDPIE-AAEDADVLYTDVWISMGDDKDKEEVLKIFP 241
Query: 247 SYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMALLALV 304
+Q+N K+LE AKD++ +MH LP R EI +V + +H++ + + N + V+ + +
Sbjct: 242 PFQINSKLLEYAKDDVIVMHCLPANRGYEITDDVIDGEHSVVYDEAENRLHVQKGVFKFI 301
>sp|P31326|OTC_RANCA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|477221|pir||A48421 ornithine
transcarbamylase - bullfrog >gi|213684|gb|AAA49528.1|
(M95193) ornithine carbamoyltransferase [Rana
catesbeiana] >gi|2522250|dbj|BAA22775.1| (D38304)
ornithine transcarbamylase [Rana catesbeiana]
Length = 350
Score = 115 bits (286), Expect = 5e-25
Identities = 88/299 (29%), Positives = 152/299 (50%), Gaps = 17/299 (5%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD+++++++S E+I+ +L A L+ +KEKG+ L +GK LA +F + STRTRLS
Sbjct: 34 KGRDLLTLKNYSAEEIKYLLWVAADLKYRIKEKGEYLPLLQGKSLAMIFEKRSTRTRLST 93
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL+DT + + D ++ R + + AE A
Sbjct: 94 ETGFALLGGHP-SFLTTQDIHLGVNESLKDTARVLSGMTDAVLARVYHQSDLEVLAEEAS 152
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G + HP Q L D TI++ +G + GL I +GD +HS+ + + +
Sbjct: 153 IPIVN-GLSDDYHPIQILADYLTIQEHYGHLKGLTISWIGD--GNNVLHSIMMSAAKFGM 209
Query: 183 ELYLISPELLRMPRHIVEEL----REKGMKVVETTTLEDVIGKLDVL----YVTRIQKER 234
L++ +P+ + E +E G K++ T + +VL +V+ Q+E
Sbjct: 210 HLHIATPKGYEPNSSLTEAAKQFSKECGTKLLMTNDPLEAANGANVLVTDTWVSMGQEEE 269
Query: 235 FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFN 292
++ L KG YQ+ +K + A +H LPR +E+ EV ++ F++ N
Sbjct: 270 --KKKRLLDFKG-YQITMKTAKLAAPNWIFLHCLPRKPEEVDDEVFYCPKSLVFQEAEN 325
>gb|AAF61409.1|AF134845_1 (AF134845) ornithine transcarbamylase [Alligator mississippiensis]
Length = 357
Score = 115 bits (285), Expect = 7e-25
Identities = 87/309 (28%), Positives = 159/309 (51%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++++ E+I+ +L A L++ +K KG+ L +GK LA +F + STRTRLS
Sbjct: 41 KGRDLLTLQNYTAEEIKYLLWVASDLKQRIKHKGEYLPLMQGKSLAMIFEKRSTRTRLST 100
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D I+ R K+ L A+ A
Sbjct: 101 ETGFAVLGGHPC-FLTTQDIHLGINESLTDTARVLSGMTDAILARVYKQSDLDLLAKEAS 159
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P+IN G + HP Q + D T+++ +G ++GL I +GD ++S+ + +
Sbjct: 160 IPIIN-GLSDSYHPIQIVADYLTLQEHYGHLNGLTISWIGD--GNNVLNSIMMSAAKLGM 216
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L++ +P+ I+ + +E G K++ TT LE G ++ T I + +
Sbjct: 217 HLHVATPKSFEPDYRIIKIAEQYSKEYGTKLLLTTDPLEAASGANVLVTDTWISMGQEQE 276
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+ E L+ YQ+ ++ + A + +H LPR +E+ V + ++ F++ N
Sbjct: 277 KIERLRAFQGYQITMQTAKAAASDWTFLHCLPRKPEEVDDRVFYSSRSLVFQEAENRKWT 336
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 337 IMAVMVSLL 345
>pir||E70447 ornithine carbamoyltransferase - Aquifex aeolicus
>gi|2984023|gb|AAC07566.1| (AE000752) ornithine
carbamoyltransferase [Aquifex aeolicus]
Length = 306
Score = 114 bits (283), Expect = 1e-24
Identities = 89/304 (29%), Positives = 153/304 (50%), Gaps = 17/304 (5%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESA 65
RD + + D S ++ ++ ++++ +E G+ GK +A LF +PSTRTR+SFE
Sbjct: 3 RDFVDLWDLSPKEAWEIVKKTLKVKKGEEELGKP--LSGKTIALLFTKPSTRTRVSFEVG 60
Query: 66 MHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPV 125
+++LGG + F E V +GE +RDT +T+ +Y D +++R+ + A A VPV
Sbjct: 61 IYQLGGNSLFFQEKEL-QVSRGEDVRDTARTLSKYVDGVIVRNHSHTWLKEFANFASVPV 119
Query: 126 INAGDGSNQHPTQTLLDLYTIKKEFG-RIDGLKIGLLGDLKYGRTV-HSLAEALTFYDVE 183
INA + HP Q L D++T+ + +G + LK+ +GD G V ++L + ++
Sbjct: 120 INALTNMS-HPCQILSDVFTLYEHYGEELKNLKVAYVGD---GNNVCNTLMVGAGMFGLK 175
Query: 184 LYLISPELLR----MPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQ 239
L++ +PE + +E +E G V T + + DV+Y +E
Sbjct: 176 LFVATPEGYEPNSYYYKKALEFSKENGGSVELTNNPVESVKDADVVYTD--VWVSMGEEN 233
Query: 240 EYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVR 297
+ ++ YQVN K+L AK +++MH LP + EI EV F Q N + +
Sbjct: 234 KNIEAFLPYQVNEKLLSFAKSSVKVMHCLPAKKGQEITEEVFEKNADFIFTQAENRLHTQ 293
Query: 298 MALL 301
L+
Sbjct: 294 KTLM 297
>pir||JE0309 ornithine carbamoyltransferase (EC 2.1.3.3) - chicken
>gi|4218929|gb|AAD12234.1| (AF065629) ornithine
transcarbamylase precursor [Gallus gallus]
>gi|4927368|gb|AAD33083.1| (AF065638) ornithine
transcarbamylase [Gallus gallus]
Length = 354
Score = 114 bits (283), Expect = 1e-24
Identities = 87/309 (28%), Positives = 159/309 (51%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++++ ++++ +L A L++ +K+KG+ L +GK LA +F + STRTRLS
Sbjct: 38 KGRDLLTLQNYTADELKYLLWVASDLKQRIKDKGEYLPLMQGKSLAMIFEKRSTRTRLSA 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + + I+ R K L + A
Sbjct: 98 ETGFALLGGH-SSFLTKQDIHLGTNESLTDTARVLSSMTNAILARVYKHNDLDLMTKEAT 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+PVIN G HP Q L D T+++ +G ++GL I +GD +HS+ + +
Sbjct: 157 IPVIN-GLSDLYHPLQILADYLTLQEHYGGLNGLTIAWIGD--GNNVLHSIMTSAAKLGM 213
Query: 183 ELYLISPE----LLRMPRHIVEELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L + +P+ LR+ + + +E G +++ TT LE G ++ T I + +
Sbjct: 214 HLRIATPKGFEPDLRITKVTEQYSKEYGTRLLLTTDPLEAANGANVLVTDTWISMGQEEE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
++ LK YQ+ ++ ++ A +H LPR +E+ EV + ++ F++ N
Sbjct: 274 KRRRLKAFQGYQITMQTVQSAASNWTFLHCLPRKPEEVDDEVFYSPRSLVFQEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>gb|AAF61410.1|AF134846_1 (AF134846) ornithine transcarbamylase [Trachemys scripta elegans]
Length = 354
Score = 114 bits (282), Expect = 2e-24
Identities = 87/309 (28%), Positives = 159/309 (51%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++++ E+I+ +L TA L++ +K+KG+ L +GK LA +F + STRTRLS
Sbjct: 38 KGRDLLTLQNYTAEEIKYLLWTASDLKQRIKDKGEYLPLLQGKSLAMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + + ++ R K+ L A+ A
Sbjct: 98 ETGFALLGGHPC-FLTTQDIHLGVNESLTDTARVLSSMTNAVLARVYKQSDLDLLAKEAS 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G + HP Q L D T+++ +G + GL I +GD ++S+ + + +
Sbjct: 157 IPIVN-GLSDSYHPIQILADYLTLQEHYGYLKGLTISWIGD--GNNVLNSILMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L + +P+ ++V E +E K+ TT LE G ++ T I + +
Sbjct: 214 HLRVATPKGFEPDPNVVKVAEEYSKEYSTKLFFTTDPLEAASGANVLVTDTWISMGQEEE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
++ LK YQ+ ++ + A + +H LPR +E+ EV ++ F++ N
Sbjct: 274 KESDLKAFQGYQITMQTGKHAASDWTFLHCLPRKPEEVDDEVFYFPRSLVFQEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>sp|O86132|OTCC_BACLI ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (OTCASE)
>gi|3687417|emb|CAA76778.1| (Y17554) ornithine
carbamoyltransferase [Bacillus licheniformis]
Length = 335
Score = 113 bits (281), Expect = 2e-24
Identities = 97/331 (29%), Positives = 161/331 (48%), Gaps = 34/331 (10%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGR ++ +DFS+E+I +L A++L+ + + + Y +GK +A LF +PSTRTR +F
Sbjct: 8 KGRSYLAEKDFSEEEILYLLDLAQKLKEKKAQGIRHRYLEGKNIALLFEKPSTRTRCAFT 67
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+A L GA + + K ES+ DT K + + D I R + AE + V
Sbjct: 68 TACIDL-GAHPEYLGKDDIQLGKKESIEDTAKVLGRMFDGIEFRGFEHEKVISLAEHSGV 126
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV N G HPTQ L D T+K+ GR+ G+K+ +GD + +SL ++
Sbjct: 127 PVWN-GLTDLWHPTQMLADFMTVKEHTGRVKGVKLTYIGDGR-NNVANSLLIGGAKVGMD 184
Query: 184 LYLISPELLRMPRHIVEE----LREKGMKVVETTTLEDVIGKLDVLY----VTRIQKERF 235
+ + SP+ L + IV+ E G K+ T+ + + DVLY V+ ++++F
Sbjct: 185 VRICSPQELFPDQDIVKMAEAFAEESGGKITVTSDTDKAVSGADVLYTDVWVSMGEEDKF 244
Query: 236 PDEQEYLKVKGSYQVNLKVLEK-AKDELRIMHPLPRVDEIH------------------- 275
+ + LK YQVN+ +++K D + +H LP ++H
Sbjct: 245 AERIKLLK---PYQVNMDLVKKTGNDNVIFLHCLPAFHDLHTTYGQNVYEQHGLKEMEVT 301
Query: 276 PEVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
EV +KH+ F + N + A++A LG
Sbjct: 302 DEVFRSKHSKVFDEAENRMHTIKAVMAATLG 332
>gb|AAF61408.1|AF134844_1 (AF134844) ornithine transcarbamylase [Sceloporus undulatus]
Length = 356
Score = 113 bits (280), Expect = 3e-24
Identities = 87/309 (28%), Positives = 155/309 (50%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++FS E+I+ +L + L+ +K +G+ L +GK LAT+F + STRTRLS
Sbjct: 40 KGRDLLTLQNFSAEEIKYLLWVSADLKERIKHRGEYLPLLQGKSLATIFEKRSTRTRLST 99
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F A + E++ DT + + D I+ R K L A+ A
Sbjct: 100 ETGFALLGGHPC-FLTAEDIHLGINENITDTARVLSTMTDAILARVCKHHDLELLAKEAL 158
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+PVIN G ++HP Q L D T+++ +G ++GL + +GD ++S+ + + +
Sbjct: 159 IPVIN-GLSDSEHPIQILADYLTLQEHYGSLNGLTLCWIGD--GNNVLNSIMLSAAKFGM 215
Query: 183 ELYLISPELLRMPRHIVEELREKGMKVV-----ETTTLEDVIGKLDVLYVTRIQKERFPD 237
L++ P+ + + E +K T LE G ++ T I + +
Sbjct: 216 NLHIAIPKGFEPDTMVTKTAEEYSIKYCTRLFRTTNPLEAARGANVLITDTWISMGQEEE 275
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+Q LK YQ+ +++ + A +H LPR E+ EV + ++ F++ N
Sbjct: 276 KQARLKAFQDYQITMQIGKVAAPGWTFLHCLPRKPQEVDDEVFYSPQSLVFQEAENRKWT 335
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 336 IMAVMVSLL 344
>sp|O19072|OTC_PIG ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|2293083|emb|CAA73480.1| (Y13045)
ornithine transcarbamylase [Sus scrofa]
Length = 328
Score = 112 bits (278), Expect = 5e-24
Identities = 87/309 (28%), Positives = 154/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 12 KGRDLLTLKNFTGEEIKYILWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 71
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL+DT + + D ++ R K+ + A+ A
Sbjct: 72 ETGFALLGGHPC-FLTTQDIHLGVNESLKDTARVLSSMTDAVLARVYKQSDLDILAQEAS 130
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P+IN G HP Q L D T+++ +G + GL + +GD +HS+ + + +
Sbjct: 131 IPIIN-GLSDLYHPIQILADYLTLQEHYGALKGLTLSWIGD--GNNILHSIMMSAAKFGM 187
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L + +P+ I + +E G V T LE G ++ T I + +
Sbjct: 188 HLQVATPKGYEPDPSITKLAEQYAKENGTNVSLTNDPLEAARGGNVLITDTWISMGQEEE 247
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K E A + +H LPR +E+ EV + ++ F + N
Sbjct: 248 KKKRLQAFQGYQVTMKTAEVAASDWTFLHCLPRKPEEVDDEVFYSPQSLVFPEAENRKWT 307
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 308 IMAVMVSLL 316
>gi|6679184 ornithine transcarbamylase [Mus musculus]
>gi|129277|sp|P11725|OTC_MOUSE ORNITHINE
CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|2144398|pir||OWMS ornithine
carbamoyltransferase (EC 2.1.3.3) precursor - mouse
>gi|200163|gb|AAA39865.1| (M17030) ornithine
transcarbamylase [Mus musculus]
Length = 354
Score = 110 bits (273), Expect = 2e-23
Identities = 86/309 (27%), Positives = 154/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ A+ A
Sbjct: 98 ETGFALLGGHP-SFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDTLAKEAS 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G HP Q L D T+++ +G + GL + +GD +HS+ + + +
Sbjct: 157 IPIVN-GLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ +IV + +E G K+ T LE G ++ T I + +
Sbjct: 214 HLQAATPKGYEPDPNIVKLAEQYAKENGTKLSMTNDPLEAARGGNVLITDTWISMGQEDE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>gi|6981312 ornithine carbamoyltransferase [Rattus norvegicus]
>gi|129279|sp|P00481|OTC_RAT ORNITHINE
CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|66490|pir||OWRT ornithine
carbamoyltransferase (EC 2.1.3.3) precursor - rat
>gi|205872|gb|AAA41767.1| (M11266) preornithine
transcarbamylase [Rattus norvegicus]
>gi|205874|gb|AAA41768.1| (K03040) preornithine
carbamoyltransferase EC 2.1.3.3 [Rattus norvegicus]
>gi|205886|gb|AAA41769.1| (M16933) ornithine
carbamoyltransferase [Rattus norvegicus]
Length = 354
Score = 110 bits (272), Expect = 2e-23
Identities = 85/309 (27%), Positives = 155/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ + A+ A
Sbjct: 98 ETGFALLGGHP-SFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDILAKEAT 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G HP Q L D T+++ +G + GL + +GD +HS+ + + +
Sbjct: 157 IPIVN-GLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ +IV + +E G ++ T LE G ++ T I + +
Sbjct: 214 HLQAATPKGYEPDPNIVKLAEQYAKENGTRLSMTNDPLEAARGGNVLITDTWISMGQEDE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>pir||B72502 probable ornithine carbamoyltransferase APE1992 - Aeropyrum pernix
(strain K1) >gi|5105690|dbj|BAA81002.1| (AP000063) 402aa
long hypothetical ornithine carbamoyltransferase
[Aeropyrum pernix]
Length = 402
Score = 110 bits (272), Expect = 2e-23
Identities = 88/313 (28%), Positives = 155/313 (49%), Gaps = 17/313 (5%)
Query: 4 KGRDVISIRDFSKEDIETVLA-TAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
+GR ++ + D++ E+I ++ T E R + + +G+ + LF +PSTRTR+S
Sbjct: 95 RGRHLLWLADYTGEEIRHMVELTLEMKRRYYAGERVIPVLRGRSVGLLFEKPSTRTRISL 154
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E A+ +LGG + + S + + +GE++ DT + + +Y D IV R A A
Sbjct: 155 EVAVAQLGGHTV-YMTPSETQLGRGETVADTARVLSRYLDAIVARVRSHKTLEEMARHAS 213
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+PVIN G HP Q + D+ TI ++ GR++G+K+ +GD +HSL A + +
Sbjct: 214 IPVIN-GLSDLTHPLQAIADMATILEKKGRLEGVKLAFVGD-GADNVLHSLLLAGSKLGL 271
Query: 183 ELYLISPELLRMPRHI----VEELREKGMKVVETTTLEDVIGKLDVLY----VTRIQKER 234
+ + +P +R I ++ E G V + + + DV+Y V+ Q+
Sbjct: 272 HITVATPPQIRPDERILSIALKAAEESGGSVEIVSDPYEAVRGADVVYTDVWVSMGQESM 331
Query: 235 FPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFN 292
++ + LK YQVN K++E MH LP R E+ EV + + + Q N
Sbjct: 332 AEEKVQLLK---PYQVNAKLMEATGGRAIFMHCLPAKRGQEVTDEVIDGPWSAVWDQAEN 388
Query: 293 GVPVRMALLALVL 305
+ A+L+L++
Sbjct: 389 RLHAHKAVLSLLV 401
>prf||1403355A Orn transcarbamylase [Homo sapiens]
Length = 354
Score = 108 bits (268), Expect = 7e-23
Identities = 85/309 (27%), Positives = 153/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++R+F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLRNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ + LGG F + ESL DT + + D ++ R K+ A+ A
Sbjct: 98 ETGLALLGGHPC-FLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEAS 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P+IN G HP Q L D T+++ + + GL + +GD +HS+ + + +
Sbjct: 157 IPIIN-GLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ + + +E G K++ T LE G ++ T I + +
Sbjct: 214 HLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>gb|AAF61407.1|AF134843_1 (AF134843) ornithine transcarbamylase [Raja sp.]
Length = 353
Score = 108 bits (268), Expect = 7e-23
Identities = 86/296 (29%), Positives = 144/296 (48%), Gaps = 11/296 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGR ++S++DFS E+I+ L TA L+ +K+KG+ L +GK +A +F + STRTRLS
Sbjct: 37 KGRHLLSLKDFSGEEIKQFLWTAADLKMRIKQKGEILPLLQGKSIAMIFEKRSTRTRLST 96
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ES +DT + + DVI+ R K AE
Sbjct: 97 ETGFALLGGHPC-FLTTQDIHLGVNESRKDTARVLSGMTDVILARVYKHSDLEQLAEDGT 155
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+PV+N G HP Q L D T+++ FG ++GL + +GD ++S + +
Sbjct: 156 IPVVN-GLSEMYHPIQILADYLTLQEHFGSLNGLTLSWIGD--GNNVLNSFMMSAPKLGM 212
Query: 183 ELYLISPELLRMPRHIVEELR----EKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L + +P+ + + + E G K+ T +E G ++ T + + +
Sbjct: 213 HLNVATPKGFEPDADVTKVAKSLAGECGTKLFFTNDPVEAASGANALVTDTWVSMGQEDE 272
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFN 292
+ E LK YQ+ +K + A +H LPR +E+ EV + ++ F++ N
Sbjct: 273 KAERLKAFHGYQITMKTGKSAAPNWTFLHCLPRKPEEVDDEVFYSPRSLVFQEAEN 328
>pdb|1C9Y|A Chain A, Human Ornithine Transcarbamylase: Crystallographic
Insights Into Substrate Recognition And Catalytic
Mechanism >gi|6137343|pdb|1OTH|A Chain A, Crystal
Structure Of Human Ornithine Transcarbamoylase Complexed
With N-Phosphonacetyl-L-Ornithine
Length = 321
Score = 108 bits (267), Expect = 9e-23
Identities = 85/309 (27%), Positives = 152/309 (48%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 5 KGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 64
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ A+ A
Sbjct: 65 ETGFALLGGHPC-FLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEAS 123
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P+IN G HP Q L D T+++ + + GL + +GD +HS+ + + +
Sbjct: 124 IPIIN-GLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 180
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ + + +E G K++ T LE G ++ T I R +
Sbjct: 181 HLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGREEE 240
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 241 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 300
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 301 IMAVMVSLL 309
>emb|CAA26007.1| (X01976) OTCase precursor [Rattus norvegicus]
Length = 354
Score = 108 bits (266), Expect = 1e-22
Identities = 84/309 (27%), Positives = 154/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ + A+ A
Sbjct: 98 ETGFALLGGHP-SFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDILAKEAT 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G HP Q L D T+++ +G + GL + +GD +HS+ + + +
Sbjct: 157 IPIVN-GLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ +IV + +E ++ T LE G ++ T I + +
Sbjct: 214 HLQAATPKGYEPDPNIVKLAEQYAKENSTRLSMTNDPLEAARGGNVLITDTWISMGQEDE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>gi|9257234 ornithine carbamoyltransferase precursor; Ornithine
transcarbamylase [Homo sapiens]
>gi|189407|gb|AAA59975.1| (K02100) ornithine
transcarbamylase [Homo sapiens]
Length = 354
Score = 108 bits (266), Expect = 1e-22
Identities = 85/309 (27%), Positives = 151/309 (48%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ A+ A
Sbjct: 98 ETGFALLGGHPC-FPTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEAS 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P+IN G HP Q L D T+++ + + GL + GD +HS+ + + +
Sbjct: 157 IPIIN-GLSDLYHPIQILADYLTLQEHYSSLKGLTLSCFGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ + + +E G K++ T LE G ++ T I R +
Sbjct: 214 HLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGREEE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>sp|P00480|OTC_HUMAN ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|279486|pir||OWHU ornithine
carbamoyltransferase (EC 2.1.3.3) precursor - human
>gi|219959|dbj|BAA00161.1| (D00230) ornithine
transcarbamylase [Homo sapiens]
Length = 354
Score = 107 bits (265), Expect = 2e-22
Identities = 84/309 (27%), Positives = 153/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ + LGG F + ESL DT + + D ++ R K+ A+ A
Sbjct: 98 ETGLALLGGHPC-FLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEAS 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P+IN G HP Q L D T+++ + + GL + +GD +HS+ + + +
Sbjct: 157 IPIIN-GLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ + + +E G K++ T LE G ++ T I + +
Sbjct: 214 HLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>emb|CAA30121.1| (X07092) ornithine transcarbamylase [Mus musculus]
Length = 354
Score = 107 bits (265), Expect = 2e-22
Identities = 85/309 (27%), Positives = 153/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ A+ A
Sbjct: 98 ETGFALLGGHP-SFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDTLAKEAS 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G HP Q L D T+++ +G + GL + + D +HS+ + + +
Sbjct: 157 IPIVN-GLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIRD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ +IV + +E G K+ T LE G ++ T I + +
Sbjct: 214 HLQAATPKGYEPDPNIVKLAEQYAKENGTKLSMTNDPLEAARGGNVLITDTWISMGQEDE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>gb|AAF61405.1|AF134841_1 (AF134841) ornithine transcarbamylase [Bos taurus]
Length = 354
Score = 107 bits (265), Expect = 2e-22
Identities = 84/301 (27%), Positives = 145/301 (47%), Gaps = 23/301 (7%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KGRD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ L A+ A
Sbjct: 98 ETGFALLGGHPC-FLTTDDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDLLAKEAS 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G HP Q L D T+++ +G + GL + +GD +HS+ + + +
Sbjct: 157 IPIVN-GLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L + +P+ I + +E G K+ T LE G ++ T I + +
Sbjct: 214 HLQVATPKGYEPDPSITKMAEQYAKENGTKLSLTNDPLEAACGGNVLITDTWISMGQEEE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDE-------------IHPEVDNTKHA 284
+++ L+ YQV +K + A + +H LPR E + PE +N K
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAAPDWTFLHCLPRKPEEVDDEVFYSPRSLVSPEAENRKWT 333
Query: 285 I 285
I
Sbjct: 334 I 334
>gb|AAF17704.1|AF033561_1 (AF033561) ornithine carbamoyltransferase [Canavalia lineata]
Length = 369
Score = 107 bits (264), Expect = 2e-22
Identities = 82/307 (26%), Positives = 147/307 (47%), Gaps = 11/307 (3%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSFES 64
+D + I DF K+ I +L A ++ +K + + KGK +A +F +PS RT +SFE+
Sbjct: 67 KDFLHINDFDKKSIFKILDRAIEVKALIKSGDRAFQPFKGKTMAMVFCKPSLRTHVSFET 126
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
LGG + A + E RD + + ++ D+I+ R + ++ VP
Sbjct: 127 GFTLLGGHAVYLAPTDIQMGTR-EETRDVARILSRFTDIIMARVFSHQDILVLSKYGSVP 185
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
V+N G HP Q + D TI + G+++G KI +GD VHS E + ++
Sbjct: 186 VVN-GLTDYNHPCQVMADAITIIEHIGKLEGTKIAYVGD--GNNVVHSWLEMASLVPIQF 242
Query: 185 YLISPELLRMPRHIVEELREKGM-KVVETTTLEDVIGKLDVLY--VTRIQKERFPDEQEY 241
SP+ + VE+ ++ G+ K+V T ++ + D++Y V ++ ++
Sbjct: 243 VCASPKGFEPDKKTVEKAKQAGLSKIVITNDPKEAVKGADIVYTDVWASMGQKEEADRRL 302
Query: 242 LKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRMA 299
KG +QV+ +++ A + MH LP + E+ +V +I F Q N + + A
Sbjct: 303 ASFKG-FQVDQSLMDLAGSKALFMHCLPAEKGTEVTEDVIEGPRSIIFDQAENRLHAQNA 361
Query: 300 LLALVLG 306
++ VLG
Sbjct: 362 IMLHVLG 368
>pir||T46742 ornithine carbamoyltransferase (EC 2.1.3.3) [validated] -
Lactobacillus sakei >gi|2764612|emb|CAA04683.1|
(AJ001330) ornithine transcarbamoylase [Lactobacillus
sakei]
Length = 337
Score = 105 bits (259), Expect = 8e-22
Identities = 98/334 (29%), Positives = 171/334 (50%), Gaps = 39/334 (11%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKG-QLEYAKGKILATLFFEPSTRTRLS 61
++GR +++ +DF+K ++E ++ + L ++LK+KG Y +GK +A LF + STRTR +
Sbjct: 6 FQGRSLLAEKDFTKSELEYLIDFSLHL-KDLKKKGIPHHYLEGKNIALLFEKNSTRTRAA 64
Query: 62 FESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA 121
F +A L GA F + + K ES+ DT K + D I R + L A+ +
Sbjct: 65 FTTAAIDL-GAHPEFLGKNDIQLGKKESVEDTAKVLGSMFDGIEFRALAKVVEDL-AKYS 122
Query: 122 EVPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYD 181
VPV N G HPTQ + D T+K+ FG++ G+ + +GD + +SL +
Sbjct: 123 GVPVWN-GLTDEWHPTQMIADFMTVKENFGKLKGVTLTYVGDGR-NNMANSLLVTGSMLG 180
Query: 182 VELYLISPELLRMPRHIVEEL-----REKGMKVVETTTLEDVIGKLDVLY----VTRIQK 232
V +++++P+ L+ P V +L +E G K + T+ ++ + DVLY V+ ++
Sbjct: 181 VNIHIVAPDSLQ-PTQEVRDLAEGYAKETGSKNMITSDVDAGVKGSDVLYTDVWVSMGEE 239
Query: 233 ERFPDEQEYLKVKGSYQVNLKVLEKAKDE-LRIMHPLP-----------RVD-------- 272
++F + LK YQ+N+ +++K +E + IMH LP ++D
Sbjct: 240 DKFEERVNLLK---PYQINMDMVKKTGNENMIIMHCLPAFHDIETEYGKKIDEQFGIQEM 296
Query: 273 EIHPEVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
EI E +K+A F + N + A++A LG
Sbjct: 297 EITDEAFRSKYARQFEEAENRMHSIKAIMAATLG 330
>gb|AAA41772.1| (K00001) preornithine carbamoyl transferase [Rattus norvegicus]
Length = 354
Score = 104 bits (258), Expect = 1e-21
Identities = 83/309 (26%), Positives = 153/309 (48%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
K RD++++++F+ E+I+ +L + L+ +K+KG+ L +GK L +F + STRTRLS
Sbjct: 38 KPRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLST 97
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL DT + + D ++ R K+ + A+ A
Sbjct: 98 ETGFALLGGHP-SFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDILAKEAT 156
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G HP Q L D T+++ +G + GL + +GD +HS+ + + +
Sbjct: 157 IPIVN-GLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGD--GNNILHSIMMSAAKFGM 213
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L +P+ +IV + +E ++ T LE G ++ T I + +
Sbjct: 214 HLQAATPKGYEPDPNIVKLAEQYAKENSTRLSMTNDPLEAARGGNVLITDTWISMGQEDE 273
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ L+ YQV +K + A + +H LPR +E+ EV + ++ F + N
Sbjct: 274 KKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWT 333
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 334 IMAVMVSLL 342
>pir||A70205 ornithine carbamoyltransferase, catabolic (arcB) homolog - Lyme
disease spirochete >gi|2688788|gb|AAC67190.1| (AE001183)
ornithine carbamoyltransferase, catabolic (arcB)
[Borrelia burgdorferi]
Length = 328
Score = 104 bits (257), Expect = 1e-21
Identities = 85/326 (26%), Positives = 150/326 (45%), Gaps = 26/326 (7%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
+ R +++ DF+ +DI+ +L + L++ +++ KGK + +F + STRTR +FE
Sbjct: 6 RNRSFLNLLDFTSKDIKYLLDLSINLKKSKYAGIEVQKLKGKNIVIIFEKDSTRTRCAFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A + GA I + + + + ES+ DT + + + D I R + A + V
Sbjct: 66 IAAYD-QGANITYLGSKGNQMGSKESMIDTARVLGRMYDAIGFRGFSQQTVECLANYSNV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV N G HPTQ L DL TIK+ G + G+KI GD + G +SL + ++
Sbjct: 125 PVYN-GLTDISHPTQILADLMTIKEHKGSLKGIKIVFCGDGR-GNVANSLLKGCAIMGLD 182
Query: 184 LYLISPELLRMPRHIVEELR----EKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDEQ 239
+ +P+ L + + R E G K+ T + E+ + DV+Y + +
Sbjct: 183 FRIFAPKELFPDPDLTLKARSLALESGGKITITDSKEEAVKCADVVYTDVWVSMGESNWE 242
Query: 240 EYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVD-------------------EIHPEVDN 280
+ + + +YQVN +++ AKD+ MH LP E+ E+
Sbjct: 243 DRINLLKAYQVNKEIMCMAKDDAIFMHCLPAFHDLNTVIGKDIFDKYGLDGIEVTEEIFE 302
Query: 281 TKHAIYFRQVFNGVPVRMALLALVLG 306
+K+++ F N V A++ LG
Sbjct: 303 SKNSVVFDVAENRVHTIKAIMVSTLG 328
>gb|AAC78720.1| (U43091) ornithine carbamoyltransferase [Bacillus
stearothermophilus]
Length = 311
Score = 103 bits (254), Expect = 3e-21
Identities = 91/316 (28%), Positives = 152/316 (47%), Gaps = 20/316 (6%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
M KGRD +++ DFS E+I +LA A L+ + K GK +A +F +PS TR+
Sbjct: 5 MSLKGRDFLTLLDFSTEEILDLLALAADLKAKQKAGVSYTPLSGKTMAMIFEKPS-GTRV 63
Query: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
SFE M +LGG + + + + +GE++ DT + + QY VI+IR A + E+
Sbjct: 64 SFEVGMIQLGGQAM-YLNGNHLQLGRGETIADTARVLSQYVRVIMIR---TFAHQKVEEL 119
Query: 121 AEVPVINAGDG--SNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALT 178
AE + +G + HP Q L DL TI + G+K+ +GD ++L A
Sbjct: 120 AEYASFRSSNGLTDDDHPCQALADLLTIYEVKKTFQGVKLAYVGD--GNNVANALLVAAA 177
Query: 179 FYDVELYLISPELLRMPRHIVEEL----REKGMKVVETTTLEDVIGKLDVLYV---TRIQ 231
+++ + P + VE + G +V T + D +Y T +
Sbjct: 178 KVGMDVAIACPPGYEPKKEYVEAACRVGEQTGRRVTVTHDPLVAVAGADRIYTDVWTSMG 237
Query: 232 KERFPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQ 289
+E + E L+V YQVN ++++ AK + +H LP R +E+ V + +++ F Q
Sbjct: 238 QE--SESSERLQVFQPYQVNEELVKAAKPDYLFLHCLPAHRGEEVTAGVMDGPNSVVFEQ 295
Query: 290 VFNGVPVRMALLALVL 305
N + + A+L VL
Sbjct: 296 AGNRLHAQKAILLSVL 311
>sp|Q43814|OTC_PEA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|7433603|pir||T06436 probable
ornithine carbamoyltransferase (EC 2.1.3.3) - garden pea
>gi|971168|gb|AAA74997.1| (U13684) ornithine
carbamoyltransferase [Pisum sativum]
Length = 375
Score = 102 bits (253), Expect = 4e-21
Identities = 94/312 (30%), Positives = 148/312 (47%), Gaps = 21/312 (6%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSFES 64
+D I I DF KE I +L A ++ LK + +GK ++ +F +PS RTR+SFE+
Sbjct: 73 KDFIHIDDFDKETILKILDRAIEVKTLLKSGDRTFRPFEGKTMSMIFAKPSMRTRVSFET 132
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
LGG I + + + K E RD + + +Y D+I+ R A+ A VP
Sbjct: 133 GFSLLGGHAI-YLGPNDIQMGKREETRDVARVLSRYNDIIMARVFSHQDILDLAKYASVP 191
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHS---LAEALTFYD 181
VIN G HP Q + D T+ + GR +G K+ +GD VHS LA + F+
Sbjct: 192 VIN-GLTDYNHPVQIMADALTMIEHIGRFEGTKVVYVGD--GNNIVHSWLLLAAVVPFHF 248
Query: 182 VELYLISPELLRMPRHIVEELREKGMKVVETT-TLEDVIGKLDVLY----VTRIQKERFP 236
V P+ VE+ R+ G+ +E + ++ + DV+Y + QKE
Sbjct: 249 V---CACPKGFEPDAKTVEKARKAGISKIEISHDPKEAVRGADVVYSDVWASMGQKEEAA 305
Query: 237 DEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGV 294
+E K +QV+ +++ A + MH LP R E+ EV ++I F Q N +
Sbjct: 306 YRREAFK---GFQVDQNLMDAAGSKAFFMHCLPAERGVEVTDEVVEAPYSIVFPQAENRM 362
Query: 295 PVRMALLALVLG 306
+ A++ VLG
Sbjct: 363 HAQNAIMLHVLG 374
>gb|AAB93999.1| (AF008219) ArcB [Borrelia afzelii]
Length = 328
Score = 102 bits (253), Expect = 4e-21
Identities = 87/330 (26%), Positives = 154/330 (46%), Gaps = 33/330 (10%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
+ R +++ DF+ +DI+ +L + L++ +++ KGK + +F + STRTR +FE
Sbjct: 5 RNRSFLNLLDFTSKDIKYLLDLSIDLKKSKYAGIEVQKLKGKNIVIIFEKDSTRTRCAFE 64
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A + GA I + + + ES++DT + + + D I R + A + V
Sbjct: 65 IAAYD-QGANITYLGPKGNQIGVKESMKDTARVLGRMYDAIGFRGFSQETVECLANYSNV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV N G HPTQ L DL TIK+ G + G+KI GD + G +SL + ++
Sbjct: 124 PVYN-GLTDISHPTQILADLMTIKEHKGSLKGIKIVFCGDGR-GNIANSLLKGCAIMGLD 181
Query: 184 LYLISPELLRMPRHIVEELR----EKGMKVVETTTLEDVIGKLDVLY----VTRIQKERF 235
+ +P+ L ++ + + + G K+ T + E+ + DV+Y V+ ++ +
Sbjct: 182 FRIFAPKELFPDSNLTLKAKSLALKSGGKITITDSKEEAVKCADVVYTDVWVSMGEESNW 241
Query: 236 PDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVD-------------------EIHP 276
D LK+ YQVN +++ AKD+ MH LP E+
Sbjct: 242 EDRINLLKL---YQVNKELMCMAKDDAIFMHCLPAFHDLSTVVGRDIFDKYGLDGIEVTE 298
Query: 277 EVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
E+ +K+++ F N V A++ LG
Sbjct: 299 EIFESKNSVVFDVAENRVHAIKAVMVSTLG 328
>sp|O27495|OTC_METTH ORNITHINE CARBAMOYLTRANSFERASE (OTCASE) >gi|7433596|pir||E69059
ornithine carbamoyltransferase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622559|gb|AAB85921.1| (AE000906) ornithine
carbamoyltransferase [Methanobacterium
thermoautotrophicum]
Length = 301
Score = 101 bits (249), Expect = 1e-20
Identities = 88/302 (29%), Positives = 147/302 (48%), Gaps = 20/302 (6%)
Query: 18 DIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFESAMHRLGGAVIGFA 77
D++ V+ + + + K + + +GK LA +F + STRTR+SFE ++G + +
Sbjct: 9 DMDNVVDLLDLADDYKEGKIREKILRGKTLAMIFEKSSTRTRVSFEVGAFQMGAQPL-YL 67
Query: 78 EASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVPVINAGDGSNQHPT 137
AS + +GE + DT +T+ +Y D I+IR A A VPVIN G +HP
Sbjct: 68 SASDLQLGRGEPIADTARTLSRYVDGIMIRAISHSDVVELAGEASVPVIN-GLTDLEHPC 126
Query: 138 QTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTV-HSLAEALTFYDVEL-------YLISP 189
Q L D+ TI+++ G DG ++ +GD G V HSL +++ Y P
Sbjct: 127 QALADMQTIREKLGGFDG-RLVFVGD---GNNVCHSLLLITATLGMDMDVACPPGYEPDP 182
Query: 190 ELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE-QEYLKVKGSY 248
+ M I + E G ++ + + DV+Y + DE ++ L+V Y
Sbjct: 183 GIREMAGKIAD---ETGSRIRVIHDPSEAVRGADVVYTDVWVSMGYEDEAEDRLEVFRPY 239
Query: 249 QVNLKVLEKAKDELRIMHPLPRV--DEIHPEVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
QVN++++E A E MH LP V E EV + H++ + Q N + + A++ ++G
Sbjct: 240 QVNMELMELAAPEAIFMHCLPAVRGQETTAEVIDGPHSVVWDQAENRLHAQKAIMHWLMG 299
Query: 307 VI 308
I
Sbjct: 300 DI 301
>gb|AAG13075.1|AC023754_13 (AC023754) Ornithine carbamoyltransferase [Arabidopsis thaliana]
Length = 375
Score = 101 bits (249), Expect = 1e-20
Identities = 88/308 (28%), Positives = 145/308 (46%), Gaps = 13/308 (4%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYA--KGKILATLFFEPSTRTRLSFE 63
+D ++I DF I+T+L A ++ LK G+ Y KGK ++ +F +PS RTR+SFE
Sbjct: 73 KDFLAIDDFDTATIKTILDKASEVKALLKS-GERNYLPFKGKSMSMIFAKPSMRTRVSFE 131
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+ LGG + + + + K E RD + + +Y D+I+ R A + V
Sbjct: 132 TGFFLLGGHAL-YLGPNDIQMGKREETRDVARVLSRYNDIIMARVFAHQDILDLANYSSV 190
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV+N G + HP Q + D T+ + G+++G K+ +GD VHS E +
Sbjct: 191 PVVN-GLTDHNHPCQIMADALTMIEHIGQVEGTKVVYVGD--GNNMVHSWLELASVIPFH 247
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTT--LEDVIGKLDVLYVTRIQKERFPDEQE- 240
P+ + V + ++ G+ +E T E VIG DV+Y DE E
Sbjct: 248 FVCACPKGYEPDKERVSKAKQAGLSKIEITNDPKEAVIG-ADVVYSDVWASMGQKDEAEA 306
Query: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRM 298
K +QV+ +++ A + MH LP R E+ V ++I F Q N + +
Sbjct: 307 RRKAFQGFQVDEALMKLAGQKAYFMHCLPAERGVEVTNGVVEAPYSIVFPQAENRMHAQN 366
Query: 299 ALLALVLG 306
A++ +LG
Sbjct: 367 AIMLHLLG 374
>emb|CAA27513.1| (X03879) rudimentary protein fragment [Drosophila melanogaster]
Length = 256
Score = 99.8 bits (245), Expect = 3e-20
Identities = 75/249 (30%), Positives = 121/249 (48%), Gaps = 15/249 (6%)
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+AM RLGG VI + TSSVKKGE+ R + ++RHP GA +A
Sbjct: 1 AAMLRLGGRVISM-DNITSSVKKGETWRTASRLCPAMPTSWLLRHPSPGA--VARTTFSQ 57
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
++ +H Q LLD++T + G ++GL I + R AL +
Sbjct: 58 SRLSMPACRREHSHQALLDIFTDPRVGGTVNGLTITMW------RLEEQTDRALAGPPAD 111
Query: 184 LYLISPEL------LRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPD 237
P + L+MP +V+ + ++G+K + L++ + +ERF +
Sbjct: 112 PVQCEPAVMWRRDSLQMPDEVVQFVHQRGVKQLFARDLKECAARHGCALHDSHSRERFDN 171
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVPVR 297
++Y K G + + + +AK ++HPLPR++EI E+D A YFRQ G+ +R
Sbjct: 172 VEDYEKCCGHLVLTPEHMMRAKKRSIVLHPLPRLNEISREIDLDPRAAYFRQAEYGMYIR 231
Query: 298 MALLALVLG 306
MALLA+V+G
Sbjct: 232 MALLAMVVG 240
>gb|AAF61406.1|AF134842_1 (AF134842) ornithine transcarbamylase [Xenopus laevis]
Length = 351
Score = 99.5 bits (244), Expect = 4e-20
Identities = 79/309 (25%), Positives = 155/309 (49%), Gaps = 11/309 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSF 62
KG +++++++++ E+I+ +L A L+ +K+KG+ + +GK LA +F + STRTRLS
Sbjct: 35 KGGNLLTLKNYTAEEIKYLLWVATDLKYRIKQKGEYVPLLQGKSLAMIFEKRSTRTRLSN 94
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E+ LGG F + ESL+DT + + D ++ R + L A+ A+
Sbjct: 95 ETGFALLGGHPC-FLTTQDIHLGVNESLKDTARVLSGMTDAVLARVYCQTDLDLLAKEAK 153
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
+P++N G HP Q L D T+++ +G ++GL I +GD ++S+ + + +
Sbjct: 154 IPIVN-GLSDMYHPIQILADYLTLQEHYGHLNGLTISWIGD--GNNVLNSIMMSAAKFGM 210
Query: 183 ELYLISPELLRMPRHIVEEL----REKGMKVVETT-TLEDVIGKLDVLYVTRIQKERFPD 237
L + +P+ ++ +E G K+ T LE G ++ T + + +
Sbjct: 211 NLRIATPKGYEPDSAVISAAKQFSKEFGTKLFMTNEPLEAATGANVLVTDTWVSMGQEEE 270
Query: 238 EQEYLKVKGSYQVNLKVLEKAKDELRIMHPLPR-VDEIHPEVDNTKHAIYFRQVFNGVPV 296
+++ LK YQ+ ++ + A + +H LPR +E+ V + ++ F + N
Sbjct: 271 KKKRLKDFNGYQITMQTGKVASPDWTFLHCLPRKPEEVDDAVFYSPKSLVFPEAENRKWT 330
Query: 297 RMALLALVL 305
MA++ +L
Sbjct: 331 VMAVMVALL 339
>gb|AAF17705.1|AF033562_1 (AF033562) ornithine carbamoyltransferase; OCTase [Canavalia
lineata]
Length = 359
Score = 96.3 bits (236), Expect = 4e-19
Identities = 87/309 (28%), Positives = 141/309 (45%), Gaps = 15/309 (4%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQ-LEYAKGKILATLFFEPSTRTRLSFES 64
++ + + DF K+ I +L A ++ LK + +GK ++ +F +PS RTR+SFE+
Sbjct: 57 KNFLHLDDFDKDTILKMLDRALEVKSLLKSGDRTFRPFEGKTMSMIFTKPSMRTRVSFET 116
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
LGG I + + K E RD + + +Y D+I+ R A+ A VP
Sbjct: 117 GFTLLGGHAI-YLGPDDIQMGKREETRDVARVLSRYNDIIMARVFAHQDILDLAKYATVP 175
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVEL 184
VIN G HP Q + D T+ + GR +G K+ +GD VHS +
Sbjct: 176 VIN-GLTDYNHPCQIMADALTMIEHIGRFEGTKVVYVGD--GNNIVHSWLLMASVIPFHF 232
Query: 185 YLISPELLRMPRHIVEELREKGMKVVE-TTTLEDVIGKLDVLY----VTRIQKERFPDEQ 239
P+ VE+ R+ G+ +E T ++ + DV+Y + QKE +
Sbjct: 233 VCACPKGFEPDAKTVEKARKAGISKIEITNDPKEAVKGADVVYSDVWASMGQKEEAAHRR 292
Query: 240 EYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVR 297
E K +QV+ ++ A + MH LP R E+ EV ++I F Q N + +
Sbjct: 293 EVFK---GFQVDHNLMNIAGSKAFFMHCLPAERGVEVTDEVVEASNSIVFPQAENRMHAQ 349
Query: 298 MALLALVLG 306
A++ VLG
Sbjct: 350 NAVMLHVLG 358
>sp|O50039|OTC_ARATH ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|11257116|pir||T51617 ornithine
carbamoyltransferase (EC 2.1.3.3) [validated] -
Arabidopsis thaliana >gi|2764518|emb|CAA04115.1|
(AJ000476) Ornithine carbamoyltransferase [Arabidopsis
thaliana] >gi|2764737|emb|CAA05510.1| (AJ002524)
ornithine carbamoyltransferase [Arabidopsis thaliana]
Length = 375
Score = 96.0 bits (235), Expect = 5e-19
Identities = 87/308 (28%), Positives = 142/308 (45%), Gaps = 13/308 (4%)
Query: 6 RDVISIRDFSKEDIETVLATAERLERELKEKGQLEYA--KGKILATLFFEPSTRTRLSFE 63
+D ++I DF I+T+L A ++ LK G+ Y KGK ++ +F +PS RTR+SFE
Sbjct: 73 KDFLAIDDFDTATIKTILDKASEVKALLKS-GERNYLPFKGKSMSMIFAKPSMRTRVSFE 131
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
+ LGG + + + + K E D + + +Y D+I+ R A + V
Sbjct: 132 TGFFLLGGHAL-YLGPNDIQMGKREETPDVARVLSRYNDIIMARVFAHQDILDLANYSSV 190
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV+N G + HP Q + D T+ K G+ + K+ +GD VHS E +
Sbjct: 191 PVVN-GLTDHNHPCQIMADALTMIKHIGQFERKKVVYVGD--GNNMVHSWLELASVIPFH 247
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTT--LEDVIGKLDVLYVTRIQKERFPDEQE- 240
P+ + V + ++ G+ +E T E VIG DV+Y DE E
Sbjct: 248 FVCACPKGYEPDKERVSKAKQAGLSKIEITNDPKEAVIG-ADVVYSDVWASMGQKDEAEA 306
Query: 241 YLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEVDNTKHAIYFRQVFNGVPVRM 298
K +QV+ +++ A + MH LP R E+ V ++I F Q N + +
Sbjct: 307 RRKAFQGFQVDEALMKLAGQKAYFMHCLPAERGVEVTNGVVEAPYSIVFPQAENRMHAQY 366
Query: 299 ALLALVLG 306
A++ +LG
Sbjct: 367 AIMLHLLG 374
>emb|CAB75986.1| (AJ272085) ornithine carbamoyltransferase [Staphylococcus aureus]
>gi|7106008|emb|CAB75987.1| (AJ272086) ornithine
carbamoyltransferase Otc6850 [Staphylococcus aureus]
Length = 333
Score = 90.1 bits (220), Expect = 3e-17
Identities = 86/333 (25%), Positives = 150/333 (44%), Gaps = 36/333 (10%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
+ R +++ DFS++++E +L +E L+R + K K +A LF + STRTR +FE
Sbjct: 5 RNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFE 64
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A H GA + + + S + K E+ +DT + + D I R + AE + V
Sbjct: 65 VAAHD-QGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGV 123
Query: 124 PVINAGDGSNQHPTQTLLDLYT----IKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTF 179
PV N G HPTQ L D T +KK++ I+ +GD + ++L +
Sbjct: 124 PVWN-GLTDEDHPTQVLADFLTAKEVLKKDYADIN---FTYVGDGR-NNVANALMQGAAI 178
Query: 180 YDVELYLISPELLRMPRHIVEELR----EKGMKVVETTTLEDVIGKLDVLYVTRIQKERF 235
+ +L+ P+ L ++ + E G ++ T ++ + DV+Y
Sbjct: 179 MGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGE 238
Query: 236 PDE--QEYLKVKGSYQVNLKVLEKAKDELRIM-HPLP-------------------RVDE 273
PDE +E L++ YQVN ++++K + I H LP R E
Sbjct: 239 PDEVWKERLELLKPYQVNKEMMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREME 298
Query: 274 IHPEVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
+ EV +K ++ F++ N + A++ LG
Sbjct: 299 VTDEVFESKASVVFQEAENRMHTIKAVMVATLG 331
>gb|AAD32177.1|AF125563_2 (AF125563) ornithine carbomyltransferase [Neisseria meningitidis]
Length = 331
Score = 89.7 bits (219), Expect = 4e-17
Identities = 83/306 (27%), Positives = 140/306 (45%), Gaps = 18/306 (5%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
M+ K R + + DF+ E+I L A L+ K +++ KGK +A +F + STRTR
Sbjct: 1 MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKTSTRTRC 60
Query: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
+FE A R GA + + E S S + ES++DT + + + D I R + A+
Sbjct: 61 AFEVAA-RDQGAGVTYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKY 119
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKY--GRTVHSLAEAL 177
A VPV N G + HPTQ L D T+++ G+ ++ +GD +Y G ++ L L
Sbjct: 120 AGVPVFN-GLTNEFHPTQMLADALTMREHSGKPLNQTAFAYVGDARYNMGNSLLILGAKL 178
Query: 178 TFYDVELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYVTRIQKE 233
+++ + +P+ L I+ +E G K+ T + + +D ++
Sbjct: 179 ---GMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSM 235
Query: 234 RFPDE--QEYLKVKGSYQVNLKVL-EKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQV 290
P E QE + + Y+V +++ +++ MH LP H IY
Sbjct: 236 GEPKEVWQERIDLLKDYRVTPELMAASGNPQVKFMHCLP---AFHNRETKVGEWIYETFG 292
Query: 291 FNGVPV 296
NGV V
Sbjct: 293 LNGVEV 298
>pir||E81066 ornithine carbamoyltransferase, catabolic NMB1573 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226821|gb|AAF41926.1| (AE002508) ornithine
carbamoyltransferase, catabolic [Neisseria meningitidis
MC58]
Length = 331
Score = 89.7 bits (219), Expect = 4e-17
Identities = 83/306 (27%), Positives = 140/306 (45%), Gaps = 18/306 (5%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
M+ K R + + DF+ E+I L A L+ K +++ KGK +A +F + STRTR
Sbjct: 1 MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKTSTRTRC 60
Query: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
+FE A R GA + + E S S + ES++DT + + + D I R + A+
Sbjct: 61 AFEVAA-RDQGAGVTYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFGQEVVEELAKY 119
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKY--GRTVHSLAEAL 177
A VPV N G + HPTQ L D T+++ G+ ++ +GD +Y G ++ L L
Sbjct: 120 AGVPVFN-GLTNEFHPTQMLADALTMREHSGKPLNQTAFAYVGDARYNMGNSLLILGAKL 178
Query: 178 TFYDVELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYVTRIQKE 233
+++ + +P+ L I+ +E G K+ T + + +D ++
Sbjct: 179 ---GMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSM 235
Query: 234 RFPDE--QEYLKVKGSYQVNLKVL-EKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQV 290
P E QE + + Y+V +++ +++ MH LP H IY
Sbjct: 236 GEPKEVWQERIDLLKDYRVTPELMAASGNPQVKFMHCLP---AFHNRETKVGEWIYETFG 292
Query: 291 FNGVPV 296
NGV V
Sbjct: 293 LNGVEV 298
>pir||B81801 ornithine carbamoyltransferase (EC 2.1.3.3) NMA1762 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7380404|emb|CAB84990.1| (AL162757) ornithine
transcarbamoylase [Neisseria meningitidis Z2491]
Length = 331
Score = 89.7 bits (219), Expect = 4e-17
Identities = 83/306 (27%), Positives = 140/306 (45%), Gaps = 18/306 (5%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
M+ K R + + DF+ E+I L A L+ K +++ KGK +A +F + STRTR
Sbjct: 1 MNLKNRHFLKLLDFTPEEITAYLDLAAELKAAKKAGREIQRMKGKNIALIFEKTSTRTRC 60
Query: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
+FE A R GA + + E S S + ES++DT + + + D I R + A+
Sbjct: 61 AFEVAA-RDQGAGVTYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFGQETVEELAKY 119
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKY--GRTVHSLAEAL 177
A VPV N G + HPTQ L D T+++ G+ ++ +GD +Y G ++ L L
Sbjct: 120 AGVPVFN-GLTNEFHPTQMLADALTMREHSGKPLNQTAFAYVGDARYNMGNSLLILGAKL 178
Query: 178 TFYDVELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYVTRIQKE 233
+++ + +P+ L I+ +E G K+ T + + +D ++
Sbjct: 179 ---GMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKNVDFIHTDVWVSM 235
Query: 234 RFPDE--QEYLKVKGSYQVNLKVL-EKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQV 290
P E QE + + Y+V +++ +++ MH LP H IY
Sbjct: 236 GEPKEVWQERIDLLKDYRVTPELMAASGNPQVKFMHCLP---AFHNRETKVGEWIYETFG 292
Query: 291 FNGVPV 296
NGV V
Sbjct: 293 LNGVEV 298
>emb|CAB93580.1| (AJ250129) ornithine transcarbamylase [Lactococcus lactis]
Length = 354
Score = 87.0 bits (212), Expect = 3e-16
Identities = 81/331 (24%), Positives = 153/331 (45%), Gaps = 30/331 (9%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++GR +++ +DF+ +I ++ L+ ++ Y +GK +A LF + STRTR +F
Sbjct: 15 FQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAF 74
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
+A L GA + A+ + ES DT + + D I R + A+ +
Sbjct: 75 TTAAIDL-GAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSG 133
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VPV N G + HPTQ + D T+K+ FG + GL + +GD + +SL + V
Sbjct: 134 VPVWN-GLTDDWHPTQMIADFMTVKENFGYLKGLTLVYVGDGR-NNMANSLIVTGSMLGV 191
Query: 183 ELYLISPELLRMPRHIVE---ELREK-GMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE 238
+++++P+ L + +++ + EK G K + T+ +E+ + +++Y +
Sbjct: 192 NVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYSDVWVSMGESNW 251
Query: 239 QEYLKVKGSYQVNLKVLEKA----KDELRIMHPLPRVD-------------------EIH 275
+E +K+ Y++ + +L+ +L MH LP E+
Sbjct: 252 EERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVT 311
Query: 276 PEVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
EV +K+A F + N + A++A LG
Sbjct: 312 DEVFRSKYARQFEEAENRMHSIKAIMAATLG 342
>sp|O08322|OTCA_LACPL ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (OTCASE)
>gi|1922883|emb|CAA68243.1| (X99978) anabolic ornithine
carbamoyltransferase [Lactobacillus plantarum]
Length = 340
Score = 86.2 bits (210), Expect = 4e-16
Identities = 87/329 (26%), Positives = 138/329 (41%), Gaps = 28/329 (8%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++GR + D++ ++ ++ A L+ Y +GK +A LF + STRTR +F
Sbjct: 5 FEGRSFLKEIDYTPTELAYLIDFASHLKTLKAHHIPHPYLQGKNIALLFEKTSTRTRSAF 64
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
A + LG A F ES+ DT K + D I R K+ A +
Sbjct: 65 TVAANDLG-ANPEFLGKDDIQFGTKESVVDTAKVLGSMYDGIEFRGFKQSTVEDLATYSG 123
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VPV N G HPTQ L D T+K+ FG + GL + +GD + +SL A +
Sbjct: 124 VPVWN-GLTDEWHPTQILADFLTLKEHFGHLKGLTLAYVGDGR-NNMANSLLVAGAMLGI 181
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPD 237
+ + +P L+ +V + + G VV T + + + D LY + D
Sbjct: 182 NIAIGAPVALQPAPAVVALAQQYAQAAGSTVVITADPQQAVTQADALYTDVWVSMGEQVD 241
Query: 238 EQEYLKVKGSYQVNLKVL-EKAKDELRIMHPLPRVD-------------------EIHPE 277
E +K +Q+N +L K +MH LP + EI +
Sbjct: 242 YGERIKQLLPFQINTTLLAATGKSSTIVMHCLPALHDLKTQLGAKLGEQYGMTAFEITDD 301
Query: 278 VDNTKHAIYFRQVFNGVPVRMALLALVLG 306
V +K A+ F + N +P A++A LG
Sbjct: 302 VFQSKQAVVFEEAGNRMPAIKAVMAATLG 330
>sp|P21302|OTCC_NEIGO ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (OTCASE)
>gi|279493|pir||OWNHG ornithine carbamoyltransferase (EC
2.1.3.3) - Neisseria gonorrhoeae
>gi|150241|gb|AAA25446.1| (M34930) ornithine
transcarbamoylase (argF) (EC 2.1.3.3) [Neisseria
gonorrhoeae]
Length = 331
Score = 85.0 bits (207), Expect = 1e-15
Identities = 83/318 (26%), Positives = 142/318 (44%), Gaps = 18/318 (5%)
Query: 1 MDWKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRL 60
M+ K R + + DF+ E+I L A L+ K +++ KGK +A +F + STRTR
Sbjct: 1 MNLKNRHFLKLLDFTPEEITAYLDLAAELKDAKKAGREIQRMKGKNIALIFEKTSTRTRC 60
Query: 61 SFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEV 120
+FE A R GA + E S S + ES++DT + + + D I R + A+
Sbjct: 61 AFEVAA-RDQGADRTYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFAQETVEELAKY 119
Query: 121 AEVPVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKY--GRTVHSLAEAL 177
A VPV N G + HPTQ L D T+++ G+ ++ +GD +Y G ++ L L
Sbjct: 120 AGVPVFN-GLTNEFHPTQMLADALTMREHSGKPLNQTAFAYVGDARYNMGNSLLILGAKL 178
Query: 178 TFYDVELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLYVTRIQKE 233
+++ + +P+ L I+ +E G K+ T + + + ++
Sbjct: 179 ---GMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKGVGFIHTDVWVSM 235
Query: 234 RFPDE--QEYLKVKGSYQVNLKVL-EKAKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQV 290
P E QE + + Y+V +++ +++ MH LP H IY
Sbjct: 236 GEPKEVWQERIDLLKDYRVTPELMAASGNPQVKFMHCLP---AFHNRETKVGEWIYETFG 292
Query: 291 FNGVPVRMALLALVLGVI 308
NGV V + G++
Sbjct: 293 LNGVEVTEEVFESPAGIV 310
>gb|AAF86986.1|AF282249_5 (AF282249) ArcB [Lactococcus lactis subsp. lactis]
Length = 354
Score = 85.0 bits (207), Expect = 1e-15
Identities = 80/331 (24%), Positives = 152/331 (45%), Gaps = 30/331 (9%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++GR +++ +DF+ +I ++ L+ ++ Y +GK +A LF + STRTR +F
Sbjct: 15 FQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAF 74
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
+A L GA + A+ + ES DT + + D I R + A+ +
Sbjct: 75 TTAAIDL-GAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSG 133
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VPV N G + HPTQ + D T+K+ FG + GL + +GD + +SL + V
Sbjct: 134 VPVWN-GLTDDWHPTQMIADFMTVKENFGYLKGLTLVYVGDGR-NNMANSLIVTGSMLGV 191
Query: 183 ELYLISPELLRMPRHIVE---ELREK-GMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE 238
+++++P+ L + +++ + EK G K + T+ +E+ + +++Y +
Sbjct: 192 NVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYSDVWVSMGESNW 251
Query: 239 QEYLKVKGSYQVNLKVLEKA----KDELRIMHPLPRVDEIHPE----------------- 277
+E +K+ Y++ + +L+ +L MH LP + E
Sbjct: 252 EERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVT 311
Query: 278 --VDNTKHAIYFRQVFNGVPVRMALLALVLG 306
V +K+A F + N + A++A LG
Sbjct: 312 DAVFRSKYARQFEEAENRMHSIKAIMAATLG 342
>sp|P14995|OTC_PACTA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (OTCASE) (ORNITHINE
TRANSCARBAMYLASE) >gi|279490|pir||OWCKPT ornithine
carbamoyltransferase (EC 2.1.3.3) precursor - yeast
(Pachysolen tannophilus) >gi|3267|emb|CAA33458.1|
(X15412) ornithine carbamoyltransferase preprotein
[Pachysolen tannophilus]
Length = 347
Score = 84.3 bits (205), Expect = 2e-15
Identities = 78/310 (25%), Positives = 146/310 (46%), Gaps = 16/310 (5%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEK--GQLEYAKGKILATLFFEPSTRTRLS 61
K R ++S+ + S +++E+++ A +++++ + GK ++ +F + STRTR+S
Sbjct: 31 KPRHLVSMLELSIKELESLVNRAAYHKQQIRSGLVNTTQPLSGKTVSLIFNKRSTRTRVS 90
Query: 62 FESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVA 121
E A LGG + F + ESL DT K + I R K + + +
Sbjct: 91 SEGAAAYLGGCPM-FLGKDDIQLGVNESLHDTTKIISSMTSSIFARVNKHSDIQEMCKYS 149
Query: 122 EVPVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKYGRTVHSLAEALTFY 180
VP+INA HP Q + D+ TIK+ FG GLK+ +GD+ ++ L A
Sbjct: 150 SVPIINA-LCDTFHPLQAITDILTIKESFGNTTKGLKLAWIGDV--NNVINDLCIAALKS 206
Query: 181 DVELYLISPELLRMPRHIVEELREKGMK-----VVETTTLEDVIGKLDVLYVTRIQKERF 235
+++ + P L+ I+ +E + + LE + G ++ T I +
Sbjct: 207 GIDVSIAVPSGLKFEELILSGAKEISAENGTTLKITNDPLEAINGANVIVTDTWISMGQE 266
Query: 236 PDEQEYLKVKGSYQVNLKVLEKAK--DELRIMHPLPR-VDEIHPEV-DNTKHAIYFRQVF 291
+ + LK +Q+ +++ K K + + MH LPR +E+H EV + + ++ F +
Sbjct: 267 DERLQKLKQFEGFQITKEMISKGKAAENWKFMHCLPRHPEEVHDEVFYDEERSLVFEEGE 326
Query: 292 NGVPVRMALL 301
N + +A+L
Sbjct: 327 NRLYAAIAVL 336
>pir||F82066 ornithine carbamoyltransferase VC2508 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657091|gb|AAF95650.1|
(AE004321) ornithine carbamoyltransferase [Vibrio
cholerae]
Length = 334
Score = 83.1 bits (202), Expect = 4e-15
Identities = 84/332 (25%), Positives = 150/332 (44%), Gaps = 33/332 (9%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
+ R+ + + DF+ ++I +L + L+R + + +GK +A +F + STRTR +FE
Sbjct: 6 RNRNFLKLLDFTPKEIHFLLDLSAELKRAKYAGTEQKTLQGKNIALIFEKSSTRTRCAFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A GA + + S S + ES++DT + + + D I R + + + A V
Sbjct: 66 VAAFD-QGAQVSYIGPSGSQIGHKESMKDTARVLGRMYDGIQYRGFGQEIVEVLGQYAGV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGR---IDGLKIGLLGDLKYGRTVHSLAEALTFY 180
PV N G HPTQ L DL T+ +E+GR + +K LGD + +SL
Sbjct: 125 PVWN-GLTDEFHPTQILADLLTM-QEYGRSKQLHEMKFAYLGDAR-NNMGNSLMVGAAKM 181
Query: 181 DVELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLY--VTRIQKER 234
+++ L++P+ +V E ++ G K+ T +++ + D LY V E
Sbjct: 182 GMDIRLVAPKAYWPNDALVATCQEIAKQTGAKITLTEEVQEGVKGCDFLYTDVWVSMGEA 241
Query: 235 FPDEQEYLKVKGSYQVNLKVLE-KAKDELRIMHPLPRVD-------------------EI 274
E + + YQVN+ V++ +++ MH LP E+
Sbjct: 242 ADAWDERVALMKPYQVNMDVIKATGNPQVKFMHCLPAFHDDQTKVGQEIAAKYGMQGLEV 301
Query: 275 HPEVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
EV ++++I F + N + A++ LG
Sbjct: 302 TEEVFESEYSIVFDEAENRLHTIKAVMVATLG 333
>sp|Q46169|OTCC_CLOPE ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (OTCASE)
>gi|1321787|emb|CAA66365.1| (X97768) ornithine carbamoyl
transferase [Clostridium perfringens]
Length = 331
Score = 81.9 bits (199), Expect = 8e-15
Identities = 81/331 (24%), Positives = 148/331 (44%), Gaps = 34/331 (10%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGR ++++DF+ +I +L + L+ + + + KGK + LF + STRTR +FE
Sbjct: 6 KGRSFLTLKDFTPAEIRYLLDLSHDLKAKKRAGILGDSLKGKNVVLLFEKTSTRTRCAFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
G V + S + K ES+ DT K + + D I R K+ A+ A V
Sbjct: 66 CGAAEEGAHV---TFLTNSQMGKKESIEDTAKVLGRMYDGIEFRGFKQSTVEELAKHAGV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
PV N G HPTQ L D TI++ + + +K+ G + + ++L +
Sbjct: 123 PVWN-GLTDADHPTQILADFLTIEEHAHKPLSAIKLVFTGHTRNNMS-YALMYGAAKMGM 180
Query: 183 ELYLISPELLRMPRHIVEEL----REKGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE 238
+ P+ L+ I++E+ +E G + ++ +++ + DV+Y T I DE
Sbjct: 181 HFVALGPDSLKPDEDILKEMQEYSKETGATIEFSSNVDEAVKGADVIY-TDIWVSMGEDE 239
Query: 239 QEY---LKVKGSYQVNLKVLEKAKDELRI-MHPLPR-------------------VDEIH 275
Y +K+ Y+V +++ K ++ + MH LP + E+
Sbjct: 240 SLYPERVKLLTPYKVTREMMNKTGNKNTLFMHCLPSFHDEDTEVCKDRWIDLGLDIREVE 299
Query: 276 PEVDNTKHAIYFRQVFNGVPVRMALLALVLG 306
EV +K+++ F + N + A++ G
Sbjct: 300 DEVFRSKNSVVFDEAENRMHTIKAVMVATAG 330
>pir||F75562 ornithine carbamoyltransferase - Deinococcus radiodurans (strain
R1) >gi|6457745|gb|AAF09673.1|AE001871_5 (AE001871)
ornithine carbamoyltransferase [Deinococcus radiodurans]
Length = 353
Score = 81.5 bits (198), Expect = 1e-14
Identities = 85/306 (27%), Positives = 139/306 (44%), Gaps = 11/306 (3%)
Query: 5 GRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFES 64
GRD +S D + ++ V+ TA ++ E ++ G LA +F + S RTR +F+
Sbjct: 49 GRDFLSNLDMTSAELRAVMDTAHSMKAG--EWRAVKPLSGLSLALVFEKASLRTRTTFDV 106
Query: 65 AMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEVP 124
M++LGG I + + E + D + +E++ D ++ R + A+ A +P
Sbjct: 107 GMYQLGGHAITLSNTEI-GLGTRERVSDVARNLERWVDGVMGRVYLQQTLVELAQHARIP 165
Query: 125 VINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
VIN G HP Q L D TI++EFG+ + G ++ +GD H LT DV
Sbjct: 166 VIN-GLSDMLHPAQLLADYQTIEEEFGQDLRGKRVVYIGDGNNLANSHIHMGILTGTDVT 224
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDEQEYL 242
+++P ++ + + G++V T L D I DVLY I + +
Sbjct: 225 --VVTPVGYEPNAGVLMDAVKAGVEVHLTNDL-DAIQGADVLYTDVWISMGQEAEADIRR 281
Query: 243 KVKGSYQVNLKVLEKAKDELRIMHPLPR--VDEIHPEVDNTKHAIYFRQVFNGVPVRMAL 300
+ YQV ++LE + +H LP +E PE + F Q N + + AL
Sbjct: 282 RAFRGYQVTPEMLETISPDGIFLHCLPAHYGEETVPEATEHPKSRVFDQAENRLHAQKAL 341
Query: 301 LALVLG 306
L VLG
Sbjct: 342 LYHVLG 347
>sp|P23752|OTCC_PSESH ORNITHINE CARBAMOYLTRANSFERASE, PHASEOLOTOXIN-INSENSITIVE,
CATABOLIC (OTCASE) >gi|279496|pir||OWPSY ornithine
carbamoyltransferase (EC 2.1.3.3) - Pseudomonas syringae
pv. phaseolicola >gi|151043|gb|AAA25722.1| (M94049)
ornithine carbamoyltransferase [Pseudomonas syringae]
>gi|2077926|dbj|BAA19878.1| (D86356) phaseolotoxin
resistant ornithine carbamoyltransferase [Pseudomonas
syringae]
Length = 327
Score = 81.1 bits (197), Expect = 1e-14
Identities = 75/281 (26%), Positives = 131/281 (45%), Gaps = 9/281 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
K R+++++ +F++ ++ ++ A +R K++ + +F +PS RT SF
Sbjct: 7 KNRNLLTMNEFNQSELSHLIDRAIECKRLKKDRIFNLGLNHLNICGIFLKPSGRTSTSFV 66
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A + GA F A ES++D + V + D I R + A A+ + +
Sbjct: 67 VASYD-EGAHFQFFPADNIRFGHKESIKDFARVVGRLFDGIAFRGFEHEVAEELAKHSGI 125
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV NA ++ HPTQ L D+ T+K+EFGRI+G+ I +GD + V SLA +
Sbjct: 126 PVWNALTDTH-HPTQVLADVMTVKEEFGRIEGVTIAYVGDGR-NNMVTSLAIGALKFGYN 183
Query: 184 LYLISPELLR----MPRHIVEELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDE 238
L +I+P L + I E+ E+ + T + + + DV+Y I
Sbjct: 184 LRIIAPNALHPTDAVLAGIYEQTPERNGSIEIFTEVAAGVHQADVIYTDVWISMGESVSV 243
Query: 239 QEYLKVKGSYQVNLKVLE-KAKDELRIMHPLPRVDEIHPEV 278
+E + + Y+V K++ K + MH LP ++ EV
Sbjct: 244 EERIALLKPYKVTEKMMALTGKADTIFMHCLPAFHDLDTEV 284
>gb|AAK41159.1| Ornithine carbamoyltransferase (argF) [Sulfolobus solfataricus]
Length = 307
Score = 80.8 bits (196), Expect = 2e-14
Identities = 88/315 (27%), Positives = 153/315 (47%), Gaps = 21/315 (6%)
Query: 3 WKGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSF 62
++G+ ++ + DF +IE +L + ++ + GK +A LF +PSTRTR+S
Sbjct: 2 FRGKSLLCLLDFQTHEIEKMLEVSFLMKSYVYYNKVPNSLSGKRVALLFEKPSTRTRVST 61
Query: 63 ESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAE 122
E A+ LGG I +GE + DT + + + + I R E +
Sbjct: 62 ELAVSLLGGIPI-VLNKQDLQWSRGELIEDTGRVLGRVVNGIGARVLNHLTLVKLKESSG 120
Query: 123 VPVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
VPV N + HP Q L DL TI++ FG + +KI +GD + SL + +
Sbjct: 121 VPVFNLLSDLS-HPLQALADLMTIRERFGN-NLVKIAFVGD-GSDNVLLSLMAIVAKLGL 177
Query: 183 ELYLISPELLRMPR----HIVEELREKGMKVVE--TTTLEDVIGKLDVLYV---TRIQKE 233
EL++ +P+ L+ PR I+ E+ E V+E E V G + V+Y + +E
Sbjct: 178 ELHVATPKELK-PRDDLYKIISEIAEDTGSVIEFHEDPYEAVRG-VHVVYTDVWVSMGQE 235
Query: 234 RFPDEQEYLKVKGSYQVNLKVLEKAKDELRIMHPLP--RVDEIHPEV-DNTKHAIYFRQV 290
++++ ++ +Y+V +++ A + MH LP R +E+ PEV D +K A++ Q
Sbjct: 236 NIAEQKK--RMLQNYRVTADLMKYAVKDAIFMHCLPANRGEEVDPEVIDGSKSAVW-DQA 292
Query: 291 FNGVPVRMALLALVL 305
N + MA+ +L +
Sbjct: 293 ENRLYTTMAVFSLFI 307
>sp|O31018|OTCC_RHIET ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (OTCASE)
>gi|2555171|gb|AAC46019.1| (AF025543) ArcB; catabolic
ornithine carbamoyltransferase; cOTCase [Rhizobium etli]
Length = 334
Score = 80.8 bits (196), Expect = 2e-14
Identities = 69/274 (25%), Positives = 129/274 (46%), Gaps = 11/274 (4%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
+ R +++++D++ + +L A L+R + + E+ KGK + +F + STRTR +FE
Sbjct: 6 RNRSLLTVQDYTPREFRYLLDLARDLKRAKYARTEQEHLKGKEICLIFEKTSTRTRCAFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A GA + + + S S + ES +DT + + + D I R + A+ A V
Sbjct: 66 VACSD-QGANVTYLDPSGSQIGHKESFKDTARVLGRMYDAIEYRGSAQKGVETLAKYAGV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
PV N G HPTQ + D+ T+++ + I +K +GD + HSL +
Sbjct: 125 PVYN-GLTDEYHPTQMIADVMTMREHSDKPIAEIKYAYVGDTR-SNMGHSLLIVGCLLGM 182
Query: 183 ELYLISPELLRMPRH---IVEELRE-KGMKVVETTTLEDVIGKLDVLYVTRIQKERFPDE 238
++ + P L I + L++ G +++ T + + +D ++ P E
Sbjct: 183 DVRICGPRSLWPSEEYMKIAKVLQQASGARLLVTEDPREAVKDVDFIHTDVWVSMGEPKE 242
Query: 239 --QEYLKVKGSYQVNLKVLE-KAKDELRIMHPLP 269
+E +K+ YQVN +++ + + MH LP
Sbjct: 243 VWRERIKLLTPYQVNQDLMKATGNPQTKFMHCLP 276
>gb|AAD01405.1| (AF007428) ornithine carbamoyltransferase homolog [Haemophilus
paragallinarum]
Length = 334
Score = 79.2 bits (192), Expect = 6e-14
Identities = 76/301 (25%), Positives = 143/301 (47%), Gaps = 12/301 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
K R ++S+ + ++I+ +L A+ L++ + KGK +A +F + STRTR SFE
Sbjct: 6 KNRHLLSLVHHTPQEIQFLLQLAKELKQAKYTGTEQPRLKGKNIALIFEKTSTRTRCSFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A + GA + + + ++S + ES++DT + + + D I R K+ AE A V
Sbjct: 66 VAAYD-QGANVTYIDPNSSQIGHKESMKDTARVLGRMYDAIEYRGFKQAVVNELAEYAGV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
PV N G HPTQ L D+ T+ + + + + +GD + +SL +
Sbjct: 125 PVFN-GLTDEFHPTQMLADVLTMMEHSDKPLSDIIYVYIGDAR-NNMGNSLLLIGAKLGM 182
Query: 183 ELYLISPELLRMPRHIV----EELREKGMKVVETTTLEDVIGKLDVLY--VTRIQKERFP 236
++ + +P+ L+ +V E ++ G ++ T +E + +D ++ V E
Sbjct: 183 DVRICAPKALQPEAELVAMCQEFAQQTGARITITEDVELAVKGVDFVHTDVWVSMGEPLE 242
Query: 237 DEQEYLKVKGSYQVNLKVLEKA-KDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVP 295
E + + YQV +++++ +++ MH LP EV K A + + NG+
Sbjct: 243 SWGERINLLLPYQVTPALMQRSGNPKVKFMHCLPAFHNCETEV-GKKIAEKYPHLANGIE 301
Query: 296 V 296
V
Sbjct: 302 V 302
>prf||1707278A Orn carbamoyltransferase [Pseudomonas syringae pv. phaseolicola]
Length = 327
Score = 78.4 bits (190), Expect = 1e-13
Identities = 74/281 (26%), Positives = 130/281 (45%), Gaps = 9/281 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
K R+++++ F++ ++ ++ A +R K++ + +F +PS RT SF
Sbjct: 7 KNRNLLTMNFFNQSELSHLIDRAIECKRLKKDRIFNLGLNHLNICGIFLKPSGRTSTSFV 66
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A + GA F A ES++D + V + D I R + A A+ + +
Sbjct: 67 VASYD-EGAHFQFFPADNIRFGHKESIKDFARVVGRLFDGIAFRGFEHEVAEELAKHSGI 125
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV NA ++ HPTQ L D+ T+K+EFGRI+G+ I +GD + V SLA +
Sbjct: 126 PVWNALTDTH-HPTQVLADVMTVKEEFGRIEGVTIAYVGDGR-NNMVTSLAIGALKFGYN 183
Query: 184 LYLISPELLR----MPRHIVEELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDE 238
+ +I+P L + I E+ E+ + T + + + DV+Y I
Sbjct: 184 IRIIAPNALHPTDAVLAGIYEQTPERNGSIEIFTEVAAGVHQADVIYTDVWISMGESVSV 243
Query: 239 QEYLKVKGSYQVNLKVLE-KAKDELRIMHPLPRVDEIHPEV 278
+E + + Y+V K++ K + MH LP ++ EV
Sbjct: 244 EERIALLKPYKVTEKMMALTGKADTIFMHCLPAFHDLDTEV 284
>emb|CAA39136.1| (X55520) phaseolotoxin-insensitive ornithine carbamoyltransferase
[Pseudomonas syringae]
Length = 327
Score = 78.4 bits (190), Expect = 1e-13
Identities = 74/281 (26%), Positives = 130/281 (45%), Gaps = 9/281 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
K R+++++ +F++ ++ ++ A +R K++ + +F +PS RT SF
Sbjct: 7 KNRNLLTMNEFNQSELSHLIDRAIECKRLKKDRIFNLGLNHLNICGIFLKPSGRTSTSFV 66
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A + GA F A ES++D + V + D I R + A A+ + +
Sbjct: 67 VASYD-EGAHFQFFPADNIRFGHKESIKDFARVVGRLFDGIAFRGFEHEVAEELAKHSGI 125
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV NA ++ HPTQ L D+ T+K+EFG I+G+ I +GD + V SLA +
Sbjct: 126 PVWNALTDTH-HPTQVLADVMTVKEEFGPIEGVTIAYVGDGR-NNMVTSLAIGALKFGYN 183
Query: 184 LYLISPELLR----MPRHIVEELREKGMKVVETTTLEDVIGKLDVLYV-TRIQKERFPDE 238
L +I+P L + I E+ E+ + T + + + DV+Y I
Sbjct: 184 LRIIAPNALHPTDAVLAGIYEQTPERNGSIEIFTEVAAGVHQADVIYTDVWISMGESVSV 243
Query: 239 QEYLKVKGSYQVNLKVLE-KAKDELRIMHPLPRVDEIHPEV 278
+E + + Y+V K++ K + MH LP ++ EV
Sbjct: 244 EERIALLKPYKVTEKMMALTGKADTIFMHCLPAFHDLDTEV 284
>sp|P44770|OTCC_HAEIN ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (OTCASE)
>gi|1075091|pir||H64079 ornithine carbamoyltransferase
(EC 2.1.3.3) - Haemophilus influenzae (strain Rd KW20)
>gi|1573585|gb|AAC22253.1| (U32741) ornithine
carbamoyltransferase (arcB) [Haemophilus influenzae Rd]
Length = 334
Score = 76.9 bits (186), Expect = 3e-13
Identities = 73/301 (24%), Positives = 145/301 (47%), Gaps = 12/301 (3%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
K R ++S+ ++ +I+ +L + L+R + + KGK +A +F + STRTR +FE
Sbjct: 6 KNRHLLSLVHHTEREIKYLLDLSRDLKRAKYAGTEQQKLKGKNIALIFEKTSTRTRCAFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
A + GA + + + ++S + ES++DT + + + D I R K+ + A+ A V
Sbjct: 66 VAAYD-QGAQVTYIDPNSSQIGHKESMKDTARVLGRMYDGIEYRGFKQSIVQELADYAGV 124
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLLGDLKYGRTVHSLAEALTFYDV 182
PV N G HPTQ L D+ T+ + + + + +GD + +SL +
Sbjct: 125 PVFN-GLTDEFHPTQMLADVLTMIEHCDKPLSEISYVYIGDAR-NNMGNSLLLIGAKLGM 182
Query: 183 ELYLISPELLRMPRHIVEE----LREKGMKVVETTTLEDVIGKLDVLY--VTRIQKERFP 236
++ + P+ L ++VE +E G ++ T ++ + +D ++ V E
Sbjct: 183 DVRICGPKALLPEANLVEMCEKFAKESGARITVTEDIDKAVKGVDFIHTDVWVSMGEPLE 242
Query: 237 DEQEYLKVKGSYQVNLKVLEK-AKDELRIMHPLPRVDEIHPEVDNTKHAIYFRQVFNGVP 295
E +K+ YQV +++++ +++ MH LP +V + A + ++ NG+
Sbjct: 243 TWGERIKLLLPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKV-GRQIAEKYPELANGIE 301
Query: 296 V 296
V
Sbjct: 302 V 302
>emb|CAA66276.1| (X97684) ornithine carbamoyl transferase [Clostridium perfringens]
Length = 217
Score = 74.9 bits (181), Expect = 1e-12
Identities = 59/214 (27%), Positives = 102/214 (47%), Gaps = 6/214 (2%)
Query: 4 KGRDVISIRDFSKEDIETVLATAERLERELKEKGQLEYAKGKILATLFFEPSTRTRLSFE 63
KGR ++++DF+ +I +L + L+ + + + KGK + LF + STRTR +FE
Sbjct: 6 KGRSFLTLKDFTPAEIRYLLDLSHDLKAKKRAGILGDSLKGKNVVLLFEKTSTRTRCAFE 65
Query: 64 SAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCDVIVIRHPKEGAARLAAEVAEV 123
G V + S + K ES+ DT K + + D I R K+ A+ A V
Sbjct: 66 CGAAEEGAHV---TFLTNSQMGKKESIEDTAKVLGRMYDGIEFRGFKQSTVEELAKHAGV 122
Query: 124 PVINAGDGSNQHPTQTLLDLYTIKKEFGRIDGLKIGLLGDLKYGRTVHSLAEALTFYDVE 183
PV+N G HPTQ L D TI+ + +K+ GD + + ++L +
Sbjct: 123 PVVN-GLTDADHPTQILADFLTIEAH-KPLSEIKLVFTGDTRNNMS-YALMYGAAKMGMH 179
Query: 184 LYLISPELLRMPRHIVEELREKGMKVVETTTLED 217
+ P+ L+ I++E++E + +E ++ D
Sbjct: 180 FVALGPDSLKPDEDILKEMQEYSKETIEFSSNVD 213
>pir||S24720 ornithine carbamoyltransferase (EC 2.1.3.3) - Neisseria gonorrhoeae
(strain FA19) (fragment)
Length = 280
Score = 70.6 bits (170), Expect = 2e-11
Identities = 72/276 (26%), Positives = 122/276 (44%), Gaps = 18/276 (6%)
Query: 43 KGKILATLFFEPSTRTRLSFESAMHRLGGAVIGFAEASTSSVKKGESLRDTIKTVEQYCD 102
KGK +A +F + STRTR +FE A R GA + E S S + ES++DT + + + D
Sbjct: 3 KGKNIALIFEKTSTRTRCAFEVAA-RDQGAAATYLEPSASQIGHKESIKDTARVLGRMYD 61
Query: 103 VIVIRHPKEGAARLAAEVAEVPVINAGDGSNQHPTQTLLDLYTIKKEFGR-IDGLKIGLL 161
I R + A+ A VPV N G + HPTQ L D T+++ G+ ++ +
Sbjct: 62 AIEYRGFAQETVEELAKYAGVPVFN-GLTNEFHPTQMLADALTMREHSGKPLNQTAFAYV 120
Query: 162 GDLKY--GRTVHSLAEALTFYDVELYLISPELLRMPRHIV----EELREKGMKVVETTTL 215
GD +Y G ++ L L +++ + +P+ L I+ +E G K+ T
Sbjct: 121 GDARYNMGNSLLILGAKL---GMDVRIGAPQSLWPSEGIIAAAHAAAKETGAKITLTENA 177
Query: 216 EDVIGKLDVLYVTRIQKERFPDE--QEYLKVKGSYQVNLKVL-EKAKDELRIMHPLPRVD 272
+ + + ++ P E QE + + Y+V +++ +++ MH LP
Sbjct: 178 HEAVKGVGFIHTDVWVSMGEPKEVWQERIDLLKDYRVTPELMAASGNPQVKFMHCLP--- 234
Query: 273 EIHPEVDNTKHAIYFRQVFNGVPVRMALLALVLGVI 308
H IY NGV V + G++
Sbjct: 235 AFHNRETKVGEWIYETFGLNGVEVTEEVFESPAGIV 270
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.138 0.383
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106187661
Number of Sequences: 2977
Number of extensions: 4344184
Number of successful extensions: 13269
Number of sequences better than 1.0e-10: 199
Number of HSP's better than 0.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 12645
Number of HSP's gapped (non-prelim): 200
length of query: 308
length of database: 189,106,746
effective HSP length: 58
effective length of query: 250
effective length of database: 154,394,500
effective search space: 38598625000
effective search space used: 38598625000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)