BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1518 (nhe2) DE:Na+/H+ antiporter, putative
(443 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75038 probable sodium/proton exchanging protein PAB1518 [s... 860 0.0
emb|CAC12029.1| (AL445065) Na+/H+ antiporter related protein [Th... 249 5e-65
sp|Q60362|Y057_METJA PUTATIVE NA(+)/H(+) EXCHANGER MJ0057 >gi|21... 213 4e-54
sp|Q58916|YF21_METJA PUTATIVE NA(+)/H(+) EXCHANGER MJ1521 >gi|28... 203 5e-51
pir||H64489 hypothetical protein MJ1521 - Methanococcus jannaschii 203 5e-51
dbj|BAB07757.1| (AP001520) Na+/H+ antiporter [Bacillus halodurans] 155 1e-36
gi|11498452 Na+/H+ antiporter (nhe2) [Archaeoglobus fulgidus] >g... 127 3e-28
pir||S75742 hypothetical protein sll0556 - Synechocystis sp. (st... 108 2e-22
pir||S75063 Na+/H+-exchanging protein slr1727 - Synechocystis sp... 103 4e-21
pir||C82043 conserved hypothetical protein VC2703 [imported] - V... 103 4e-21
pir||T35371 probable Na+/H+ antiporter - Streptomyces coelicolor... 101 2e-20
dbj|BAA89487.1| (AB029555) NhaG Na/H antiporter [Bacillus subtilis] 100 3e-20
sp|P76007|YCGO_ECOLI PUTATIVE NA(+)/H(+) EXCHANGER YCGO 100 5e-20
gi|6320663 Na+/H+ exchanger; Nhx1p [Saccharomyces cerevisiae] >g... 99 1e-19
pir||G83177 probable sodium/hydrogen antiporter PA3739 [imported... 98 2e-19
pir||A83018 probable sodium/hydrogen antiporter PA5021 [imported... 97 5e-19
pir||D64865 probable Na+/H+-exchanging protein b1191 - Escherich... 94 4e-18
gb|AAG20219.1| (AE005097) Vng2068c [Halobacterium sp. NRC-1] 93 7e-18
pir||T37706 probable sodium/hydrogen exchanger - fission yeast ... 92 2e-17
gb|AAB61290.1| (AF003741) unknown [Escherichia coli] >gi|3661474... 90 4e-17
pir||F82291 conserved hypothetical protein VC0689 [imported] - V... 90 4e-17
emb|CAB94669.1| (AL359217) possible Na+/H+ antiporter [Leishmani... 88 2e-16
pir||S76231 Na+/H+-exchanging protein sll0273 - Synechocystis sp... 87 5e-16
gb|AAF52423.2| (AE003614) Nhe3 gene product [Drosophila melanoga... 87 5e-16
pir||H75278 probable Na+/H+ antiporter - Deinococcus radiodurans... 86 9e-16
gb|AAD32689.1|AF142676_1 (AF142676) sodium-hydrogen exchanger NH... 85 2e-15
gb|AAF13702.1|AF199463_1 (AF199463) sodium-hydrogen exchanger NH... 85 2e-15
gb|AAF51559.1| (AE003590) Nhe1 gene product [Drosophila melanoga... 85 2e-15
gb|AAG38538.1|AF309805_3 (AF309805) putative Na+/H+ exchanger Nh... 83 5e-15
pir||T26529 hypothetical protein Y18D10A.6 - Caenorhabditis eleg... 82 2e-14
pir||T22848 hypothetical protein F57C7.2 - Caenorhabditis elegan... 81 3e-14
gi|10957419 Na+/H+ antiporter, putative [Deinococcus radiodurans... 79 1e-13
pir||T43930 hypothetical protein [imported] - Plectonema boryanu... 78 2e-13
gi|6981562 solute carrier family 9 (sodium/hydrogen exchanger 3)... 77 3e-13
pir||A75494 probable Na+/H+ antiporter - Deinococcus radiodurans... 77 3e-13
pir||C83159 Na+/H+ antiporter NhaP PA3887 [imported] - Pseudomon... 76 6e-13
sp|P26432|NAH3_RABIT SODIUM/HYDROGEN EXCHANGER 3 (NA(+)/H(+) EXC... 75 2e-12
sp|P50482|NAH2_RABIT SODIUM/HYDROGEN EXCHANGER 2 (NA(+)/H(+) EXC... 75 2e-12
pir||F69201 conserved hypothetical protein MTH760 - Methanobacte... 75 2e-12
pir||T34941 probable Na+/H+ antiporter - Streptomyces coelicolor... 75 2e-12
gi|6806921 solute carrier family 9 (sodium/hydrogen exchanger), ... 74 4e-12
sp|Q28362|NAH3_DIDMA SODIUM/HYDROGEN EXCHANGER 3 (NA(+)/H(+) EXC... 73 9e-12
gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger), ... 73 9e-12
gb|AAD41635.1|AF073299_1 (AF073299) Na+/H+ exchanger isoform 2 [... 73 9e-12
gi|11430753 solute carrier family 9 (sodium/hydrogen exchanger),... 73 9e-12
sp|P48763|NAH2_RAT SODIUM/HYDROGEN EXCHANGER 2 (NA(+)/H(+) EXCHA... 69 8e-11
sp|Q9Z0X2|NAH5_RAT SODIUM/HYDROGEN EXCHANGER 5 (NA(+)/H(+) EXCHA... 69 1e-10
>pir||G75038 probable sodium/proton exchanging protein PAB1518 [similarity] -
Pyrococcus abyssi (strain Orsay)
>gi|5458717|emb|CAB50204.1| (AJ248287) Na+/H+
antiporter, putative [Pyrococcus abyssi]
Length = 443
Score = 860 bits (2197), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MIELSLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDF 60
MIELSLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDF
Sbjct: 1 MIELSLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDF 60
Query: 61 VRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGF 120
VRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGF
Sbjct: 61 VRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGF 120
Query: 121 LFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGG 180
LFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGG
Sbjct: 121 LFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGG 180
Query: 181 IFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLA 240
IFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLA
Sbjct: 181 IFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLA 240
Query: 241 FLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAAL 300
FLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAAL
Sbjct: 241 FLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAAL 300
Query: 301 ATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFREYLFIALEG 360
ATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFREYLFIALEG
Sbjct: 301 ATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFREYLFIALEG 360
Query: 361 PRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLD 420
PRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLD
Sbjct: 361 PRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLD 420
Query: 421 VGETIKERIEEKEEEKERRKVRG 443
VGETIKERIEEKEEEKERRKVRG
Sbjct: 421 VGETIKERIEEKEEEKERRKVRG 443
>emb|CAC12029.1| (AL445065) Na+/H+ antiporter related protein [Thermoplasma
acidophilum]
Length = 432
Score = 249 bits (629), Expect = 5e-65
Identities = 145/421 (34%), Positives = 241/421 (56%), Gaps = 30/421 (7%)
Query: 12 LILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDF-----VRVFGL 66
LIL G I++ ISR+ + +PI + G++IGP+L LI + + +F + + GL
Sbjct: 15 LILVLGAIALPISRKMSVVEIPILVFLGIIIGPMLHLISPNFSVYLFSSFAGVGIGMMGL 74
Query: 67 VIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAII 126
VIIL++E HN++ ++L+ I +LDT+G+I+TA++AG +F V+ + ++GFLFGAI+
Sbjct: 75 VIILYSESHNMNLKVLRSEFYRIASLDTLGVIITAVVAGLVFTVLTGAPIIVGFLFGAIV 134
Query: 127 GATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYG-GGIFSTL 185
TDP TLIPLFR+ +V +DI ++V ES+FNDP+GI+L + I++L P +FS +
Sbjct: 135 SPTDPVTLIPLFRRVKVSEDISEILVGESLFNDPVGIILVSVGIALLAPQSSYVSLFSAM 194
Query: 186 SEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFF 245
+ + Y V YFL V+V +GI +G K+ ++ + A L L F
Sbjct: 195 NRVITFYPSIVAYFLIQVAVPSIVGIAIGFSVIYLDKKIKFENY--LTAMLLGLVIFEFT 252
Query: 246 IGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFI 305
+ E L + + TG ++GN+ +NI +E +F ++L+ L+ I
Sbjct: 253 VFESLSITPFPAIIATGAIVGNFS----DKNI--------FWSREQNFQESLSFLSAAII 300
Query: 306 FVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFRE---------YLFI 356
F+L+G+ L I S + G+ + + ++ L RPLA P L + R+ FI
Sbjct: 301 FILIGSSFTLSEIVSYILLGIALTILIVFLVRPLAVFPSLMIADARKPKMKSYYKIAAFI 360
Query: 357 ALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILK 416
+L GPRGVVP L++LP + +Y P+L V WG +I + + VL S++++TL+ PI++
Sbjct: 361 SLVGPRGVVPVVLSTLPYVVGEEYNIPVL-VTWGPLISVSALFVVLFSIVLQTLYTPIIR 419
Query: 417 D 417
+
Sbjct: 420 N 420
>sp|Q60362|Y057_METJA PUTATIVE NA(+)/H(+) EXCHANGER MJ0057 >gi|2127992|pir||A64307
hypothetical protein homolog MJ0057 - Methanococcus
jannaschii >gi|1498818|gb|AAB98037.1| (U67463) Na+/H+
antiporter [Methanococcus jannaschii]
Length = 426
Score = 213 bits (536), Expect = 4e-54
Identities = 157/435 (36%), Positives = 229/435 (52%), Gaps = 57/435 (13%)
Query: 10 LFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDFVRVFGLVII 69
L L L G + I+ + I +P+ +L GL+IGP L++IP D A EIF++ GL+ I
Sbjct: 10 LGLALVLGSLVAKIAEKLKIPDIPLLLLLGLIIGPFLQIIPSDSAMEIFEYAGPIGLIFI 69
Query: 70 LFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFL--LGFLFGAIIG 127
L + LLK+ + T+V LDTI ++T LI+GFIF +V N + +G+LFGAI
Sbjct: 70 LLGGAFTMRISLLKRVIKTVVRLDTITFLITLLISGFIFNMVLNLPYTSPVGYLFGAITA 129
Query: 128 ATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSE 187
ATDPATLIP+F + R ++ + ESIFNDPLGIV T + + + G+FS+ +
Sbjct: 130 ATDPATLIPVFSRVRTNPEVAITLEAESIFNDPLGIVSTSVILGLF------GLFSSSNP 183
Query: 188 KLGI--YAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFF 245
+ + AGG +I +G+ L + K I ++ + L A L +
Sbjct: 184 LIDLITLAGG----------AIVVGLLLAKIYEKIIIHCDFHEY--VAPLVLGGAMLLLY 231
Query: 246 IGERL-------DASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLA 298
+G+ L SGY+ + G+ LG+ + + + V F D L+
Sbjct: 232 VGDDLLPSICGYGFSGYMAVAIMGLYLGDALFRADDIDYKYI----------VSFCDDLS 281
Query: 299 ALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLL--KWWNFREYLFI 356
LA +FIFV LGA + L ++ + GLLVALG + LARPL L +F+E L+
Sbjct: 282 LLARVFIFVFLGACIKLSMLENYFIPGLLVALGSIFLARPLGVFLGLIGSKHSFKEKLYF 341
Query: 357 ALEGPRGVVPSALA------------SLPLSLALKYKSPLLTVHWGEIIMATVVITVLTS 404
ALEGPRGVVP+ALA +P S+ KY +P T G II+ T +T+L S
Sbjct: 342 ALEGPRGVVPAALAVTVGIEILKNADKIPASIT-KYITP--TDIAGTIIIGT-FMTILLS 397
Query: 405 VIVETLWIPILKDKL 419
VI+E W +L KL
Sbjct: 398 VILEASWAGMLALKL 412
>sp|Q58916|YF21_METJA PUTATIVE NA(+)/H(+) EXCHANGER MJ1521 >gi|2826428|gb|AAB99540.1|
(U67593) Na+/H+ antiporter [Methanococcus jannaschii]
Length = 422
Score = 203 bits (510), Expect = 5e-51
Identities = 138/436 (31%), Positives = 234/436 (53%), Gaps = 68/436 (15%)
Query: 12 LILFTGVISML---------ISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDFVR 62
++LF G +S+L I+++ GI +P+ ++ GL++ +L +IP+++ FDF+
Sbjct: 3 IVLFLGYLSILFAGGAIIAKIAKKIGIPDIPLLLIFGLILS-ILNVIPKNIVESSFDFIG 61
Query: 63 VFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSF--LLGF 120
FGL+I+LF + W ++K+ + I+ LD + L++ +I+G +F VF+ L+G
Sbjct: 62 NFGLIILLFIGSFEMEWNIMKRVLDVIIKLDILALLIVWIISGIVFNFVFHLPILSLIGL 121
Query: 121 LFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGG 180
LFGAI+ ATDPATLIP+F + ++ + ES+FNDPLGIV+TLI +S L G
Sbjct: 122 LFGAIVSATDPATLIPIFSSMDIDPEVAITLEAESVFNDPLGIVVTLICLSAL------G 175
Query: 181 IFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKF----IKRTGIFDFPEIEAFS 236
+ A I ++++V GI LG++ KF I + D+ I F+
Sbjct: 176 LAK---------AENPILEFFSLAVG---GIILGVIAGKFYEIIISKIKFEDY--IAPFT 221
Query: 237 LSLAFLGFFIGERL-------DASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEK 289
L LA ++ E + + SG++ + G+ +GN + K K ++ +EK
Sbjct: 222 LGLAIAFWYFAEGIFPSITGYEISGFMAVAIMGLYIGNVIVHK--------KEHKKDMEK 273
Query: 290 EVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATL-----PL 344
F D L+ I IFVLLGA +++ ++ L ALG ++LARP+ L P
Sbjct: 274 VAVFMDELSIFIRILIFVLLGASISIPLLEKYALPAFLCALGSILLARPVGVLIATAIPP 333
Query: 345 LKWWNFREYLFIALEGPRGVVPSALASLPLSLALKYKSPL---------LTVHWGEIIMA 395
++ E +++ALEGPRGVVP+ LA++ + +K+ + + T G I++A
Sbjct: 334 IR--PLTERIYLALEGPRGVVPATLAAMVYTEIMKHPNIVPKNIASLMPPTELAGTILVA 391
Query: 396 TVVITVLTSVIVETLW 411
T +T++ SV++E W
Sbjct: 392 T-FMTIIVSVVLEASW 406
>pir||H64489 hypothetical protein MJ1521 - Methanococcus jannaschii
Length = 422
Score = 203 bits (510), Expect = 5e-51
Identities = 138/436 (31%), Positives = 234/436 (53%), Gaps = 68/436 (15%)
Query: 12 LILFTGVISML---------ISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDFVR 62
++LF G +S+L I+++ GI +P+ ++ GL++ +L +IP+++ FDF+
Sbjct: 3 IVLFLGYLSILFAGGAIIAKIAKKIGIPDIPLLLIFGLILS-ILNVIPKNIVESSFDFIG 61
Query: 63 VFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSF--LLGF 120
FGL+I+LF + W ++K+ + I+ LD + L++ +I+G +F VF+ L+G
Sbjct: 62 NFGLIILLFIGSFEMEWNIMKRVLDVIIKLDILALLIVWIISGIVFNFVFHLPILSLIGL 121
Query: 121 LFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGG 180
LFGAI+ ATDPATLIP+F + ++ + ES+FNDPLGIV+TLI +S L G
Sbjct: 122 LFGAIVSATDPATLIPIFSSMDIXPEVAITLEAESVFNDPLGIVVTLICLSAL------G 175
Query: 181 IFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKF----IKRTGIFDFPEIEAFS 236
+ A I ++++V GI LG++ KF I + D+ I F+
Sbjct: 176 LAK---------AENPILEFFSLAVG---GIILGVIAGKFYEIIISKIKFEDY--IAPFT 221
Query: 237 LSLAFLGFFIGERL-------DASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEK 289
L LA ++ E + + SG++ + G+ +GN + K K ++ +EK
Sbjct: 222 LGLAIAFWYFAEGIFPSITGYEISGFMAVAIMGLYIGNVIVHK--------KEHKKDMEK 273
Query: 290 EVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATL-----PL 344
F D L+ I IFVLLGA +++ ++ L ALG ++LARP+ L P
Sbjct: 274 VAVFMDELSIFIRILIFVLLGASISIPLLEKYALPAFLCALGSILLARPVGVLIATAIPP 333
Query: 345 LKWWNFREYLFIALEGPRGVVPSALASLPLSLALKYKSPL---------LTVHWGEIIMA 395
++ E +++ALEGPRGVVP+ LA++ + +K+ + + T G I++A
Sbjct: 334 IR--PLTERIYLALEGPRGVVPATLAAMVYTEIMKHPNIVPKNIASLMPPTELAGTILVA 391
Query: 396 TVVITVLTSVIVETLW 411
T +T++ SV++E W
Sbjct: 392 T-FMTIIVSVVLEASW 406
>dbj|BAB07757.1| (AP001520) Na+/H+ antiporter [Bacillus halodurans]
Length = 490
Score = 155 bits (387), Expect = 1e-36
Identities = 120/416 (28%), Positives = 202/416 (47%), Gaps = 41/416 (9%)
Query: 12 LILFTGVISMLISRRTGISYVPIFILTGLVIGPL-LKLIPRDLAHEIF-DFVRVFGLVII 69
L+ GVI+ S R G+ + +FIL G+++G L LI D + F + +F LVII
Sbjct: 14 LLFIVGVITAKFSTRLGVPALVLFILVGMLVGSDGLGLIHFDFSQAHFAQLIGIFALVII 73
Query: 70 LFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAIIGAT 129
LF G W+ ++ ++L T G+++T+ + K V S+L +LFGAI+G+T
Sbjct: 74 LFEGGLQTKWKTVQSVAVPSLSLATFGVLITSTLVAVAAKYVLGVSWLEAYLFGAIVGST 133
Query: 130 DPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKL 189
D A + + ++ +K + T + ES NDP+ + LTL I ++ G L
Sbjct: 134 DAAAVFAVLKEQNIKDRLATTLEAESGTNDPMAVFLTLSLIELITIG--------SMNPL 185
Query: 190 GIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGER 249
++ FL+ + + LG LG LG I + + F+L+ A L + +
Sbjct: 186 HLFGS----FLWQMGAGLILGFGLGKLGSYSINKINLDSSGLYPVFALAFALLTYSVTAM 241
Query: 250 LDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLL 309
+ ASG L V +V+GN L R FN+ A + + +F++L
Sbjct: 242 IGASGLLAVYVAALVIGNQDLTYRHSIFR--------------FNEGFAWMMQMLMFIIL 287
Query: 310 GAEMNLEVIW--SNLGKGLLVALGVMILARPLAT-LPLLKW-WNFREYLFIALEGPRGVV 365
G + ++ S KG+L++L +M++ARP+A L +K ++++E LF++ G RG V
Sbjct: 288 GLLVFPNQLFEASIFIKGILLSLILMLVARPVAVFLTTIKMRFDWKEKLFLSWAGLRGAV 347
Query: 366 PSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDV 421
P LA+ P++ L+ SPL V VLTS +++ I +KL +
Sbjct: 348 PIVLATFPMTAGLE-NSPL--------FFNVVFFVVLTSALIQGSTIAHFANKLQL 394
>gi|11498452 Na+/H+ antiporter (nhe2) [Archaeoglobus fulgidus]
>gi|7429467|pir||F69355 Na+/H+ antiporter (nhe2) homolog
- Archaeoglobus fulgidus >gi|2649761|gb|AAB90396.1|
(AE001046) Na+/H+ antiporter (nhe2) [Archaeoglobus
fulgidus]
Length = 494
Score = 127 bits (315), Expect = 3e-28
Identities = 109/436 (25%), Positives = 202/436 (46%), Gaps = 59/436 (13%)
Query: 1 MIELSLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPR-DLAHEIFD 59
MIE +L E + +++ +++ + + + Y +L GL +G L L+P L+ EI
Sbjct: 1 MIEENLVEFIEILMLATAVAVTV-KFIRLPYTIALVLAGLFVG-LAGLLPEVPLSREIVF 58
Query: 60 FVRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLG 119
F+ L +LF N+ + L++N I + +G+++T + GF + L
Sbjct: 59 FIF---LPPLLFEAAMNMDLKELRENFGPIALIAFLGVVVTTTVVGFSLNWILGIPLALA 115
Query: 120 FLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGG 179
+FGA++ ATDP +++ F+ + + +I ES+ ND IV+ IA+ M++
Sbjct: 116 LIFGAMVSATDPVSVLATFKSISAPKKLSILIEGESVLNDGAAIVVFAIALEMMLK---- 171
Query: 180 GIFSTLSEKLG---IYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFS 236
G+F L+ L + GG ++G+ +G L Y+ + + I D A +
Sbjct: 172 GVFDPLNAALDFAVVCVGGA-----------AVGLAVGYLAYRILAK--IDDALVEIAVT 218
Query: 237 LSLAFLGFFIGERLDASGYLVATVTGIVLGNYK---LLKPRENIRILKRLQRAIEKEVHF 293
+ A+LGF + ER SG + G++LGNY + P + +L F
Sbjct: 219 IVAAYLGFVLAERFHFSGVIAVVAAGLILGNYGRDFSMSPTTRVIML-----------DF 267
Query: 294 NDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFREY 353
+ L IF+L+G ++ + + K +LVA+ +ILAR P++ ++ F
Sbjct: 268 WSVIVFLVNSIIFILIGVNTHITIF--SAWKEILVAIAAVILARAFVVYPVMTYYRFPNL 325
Query: 354 L--FIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLW 411
+ G RGV+ P++LAL + + LL+ A VL S++++ +
Sbjct: 326 WKHVVFWGGLRGVI-------PVALALSFGNQLLS--------AMAFGVVLFSLLLQGIS 370
Query: 412 IPILKDKLDVGETIKE 427
+ I + V E+ +E
Sbjct: 371 LEIFVKRKFVSESERE 386
>pir||S75742 hypothetical protein sll0556 - Synechocystis sp. (strain PCC 6803)
>gi|1001236|dbj|BAA10477.1| (D64003) hypothetical
protein [Synechocystis sp.]
Length = 631
Score = 108 bits (266), Expect = 2e-22
Identities = 101/427 (23%), Positives = 201/427 (46%), Gaps = 37/427 (8%)
Query: 5 SLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGP--LLKLIPRDLAHEIFDFVR 62
SL + L + G+ + +++ + + ++ G+++G L + P + + + +
Sbjct: 6 SLTLQIILTVLFGIGAQVLAGFLKLPSIVFLLIFGVILGNSGLHWIQPANFGDGL-EVIV 64
Query: 63 VFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLF 122
+ IILF G NL R L + ++ L TIG ++T + G + + L FL+
Sbjct: 65 SLSVAIILFEGGLNLGLRELGQVSGSLRNLVTIGTLITLVGGGLAAHWLAEFPWYLAFLY 124
Query: 123 GAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIF 182
G+++ T P + PL +Q +V++ + T++ E + DP+G +L ++ + +
Sbjct: 125 GSLVVVTGPTVVGPLIKQVQVQKSVATLLEGEGVLIDPVGAILAVVVLETIF----NTNV 180
Query: 183 STLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFL 242
S ++ + I G + + V +++G+ G L F+KR F ++ +
Sbjct: 181 SVETDIIEIAMG----LILRLGVGLAIGVGGGWLLSNFLKRAS-FLSEDVSNLVVLAGVW 235
Query: 243 GFFIGER--LDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAAL 300
G F + L SG + GI L + L + R+L+R F L L
Sbjct: 236 GVFGAAQASLSESGLMATVAMGIYLNSSAL----PDNRLLRR----------FKGKLTLL 281
Query: 301 ATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKW---WNFREYLFIA 357
+F+LL AE++L + LG G ++ + V++L ++ + W +N+R+ LF+A
Sbjct: 282 CVSVLFILLAAELSLS-SFGALGWGSVLTVAVLMLVIRPISIAICTWTSAFNWRQKLFVA 340
Query: 358 LEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKD 417
PRG+V +++ASL SL L + ++ G+ I + V +T++ +V ++ L L
Sbjct: 341 WIAPRGIVSASVASL-FSLLLTERG----INGGDAIKSIVFLTIMMTVFIQGLTAKPLAK 395
Query: 418 KLDVGET 424
L + +T
Sbjct: 396 LLRITDT 402
>pir||S75063 Na+/H+-exchanging protein slr1727 - Synechocystis sp. (strain PCC
6803) >gi|1653008|dbj|BAA17925.1| (D90910) eukaryotic
Na+/H+ exchanger [Synechocystis sp.]
Length = 527
Score = 103 bits (255), Expect = 4e-21
Identities = 105/444 (23%), Positives = 199/444 (44%), Gaps = 43/444 (9%)
Query: 5 SLAEALFLILFTGVISMLISRRTGISYVPI-----FILTGLVIGPLLKLIPRDLAHEIFD 59
SL+ + L F V+S+ +S T VPI + L +++G L + L + +
Sbjct: 8 SLSISYNLEQFLIVLSVSLSIATLSKTVPILRKIPYTLLLVIVGMALAFVDVKLINLSPE 67
Query: 60 FVRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLG 119
+ L +LF NL WR LK+N I T+G+++ + F +
Sbjct: 68 LIMEIFLPPLLFEAAWNLQWRNLKENWFPITLFATLGVVICVVGIAFPLSYWGGMELAIA 127
Query: 120 FLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGG 179
FL A + ATDP ++I LF++ + + T++ ES+FND + +V+ LI + + +
Sbjct: 128 FLAAAALSATDPVSVIALFKELGASKKLNTLMEGESLFNDGVAVVVFLILVGIPLGTSTF 187
Query: 180 GIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIE-AFSLS 238
+ TL+ F+ + + + G+ ++G+ T FD P +E + +L
Sbjct: 188 DLSVTLAR-----------FVTVIGIGVGCGL---VIGFSLSLLTQRFDLPFVEQSLTLV 233
Query: 239 LAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLA 298
A+ + + E L SG + V G+VLGNY R + RL +I F + +A
Sbjct: 234 SAYGAYILAENLGGSGVIGVVVVGMVLGNY---GSRIGMNPRTRLIVSI-----FWEFVA 285
Query: 299 ALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWN--------- 349
IF+L+G ++ L + +L +L+A+ +++ R ++ L N
Sbjct: 286 FFVNSIIFLLIGDQIGLSSLSDHLNL-ILIAIAAVVVTRLVSVFGLSLISNKVSDQISST 344
Query: 350 ---FREYLFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVI 406
+E + G RG V A+A L + A+ + ++ + +G ++ +V + T +
Sbjct: 345 HITLQEQTVLWWGGLRGSVAIAVA-LSVPQAIAERQAIIDIVFGVVLFTLLVQGLTTQFV 403
Query: 407 VETL-WIPILKDKLDVGETIKERI 429
++ L I +L+ E + +I
Sbjct: 404 LKGLDLIGDQPQRLEYAELVSRQI 427
>pir||C82043 conserved hypothetical protein VC2703 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657299|gb|AAF95843.1|
(AE004336) conserved hypothetical protein [Vibrio
cholerae]
Length = 581
Score = 103 bits (255), Expect = 4e-21
Identities = 100/374 (26%), Positives = 168/374 (44%), Gaps = 36/374 (9%)
Query: 12 LILFTGVISMLISRRTGISYVPIFILTGLVIGPL-LKLIPRDLAHEIFDFVRVFGLVIIL 70
L++ V+ +S + GI + +F+ G++ G + I D + + V L IIL
Sbjct: 15 LLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFD-NYPVAYLVSNLALAIIL 73
Query: 71 FTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAIIGATD 130
G + V+L T+G+ +T L+ G + +FN S L G L GAI+G+TD
Sbjct: 74 LDGGMRTRVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLLQGVLVGAIVGSTD 133
Query: 131 PATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLG 190
A + L + + + + + ES NDP+ + LT+ I++L S +
Sbjct: 134 AAAVFSLLKGRSLNERVGATLEIESGTNDPMAVFLTVTLIAVLG-----------SAETN 182
Query: 191 IYAGGVIY-FLYNVSVSISLGIFLGILGYKFIKRTGIFDFPE--IEAFSLSLAFLGFFIG 247
+ AG ++ F+ V LG+ G + + I R PE ++S + F +
Sbjct: 183 LSAGFLLLSFIQQFGVGALLGLAGGWILWWLINRN---QLPEGLYSILAVSGGLMIFALS 239
Query: 248 ERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFV 307
L SG L +TG++LGN R R+ ++ D + LA I +F+
Sbjct: 240 NALGGSGILSIYLTGLLLGN--------------RPTRSRHAILNVLDGMTWLAQIGMFL 285
Query: 308 LLGAEMNLEVIWSNLGKGLLVALGVMILARPLAT---LPLLKWWNFREYLFIALEGPRGV 364
+LG + + GL +A+G+++ ARP+A L K + RE F++ G RG
Sbjct: 286 VLGLLVTPSELMEIALPGLALAVGMILFARPIAVWIGLAPFKSFTAREKWFVSWVGLRGA 345
Query: 365 VPSALASLPLSLAL 378
VP LA P+ L
Sbjct: 346 VPIILAVFPMMAGL 359
>pir||T35371 probable Na+/H+ antiporter - Streptomyces coelicolor
>gi|5123878|emb|CAB45470.1| (AL079348) putative
Na(+)/H(+) antiporter [Streptomyces coelicolor A3(2)]
Length = 514
Score = 101 bits (249), Expect = 2e-20
Identities = 95/388 (24%), Positives = 175/388 (44%), Gaps = 31/388 (7%)
Query: 13 ILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDFVRVFGLVIILFT 72
+L + + + R G+ + +F+ GLV G + D A ++ + L +IL
Sbjct: 16 VLLASIAAARAAHRIGLPSLLLFLCVGLVAGEDGLGLRFDDA-QLAQALGAAALALILVE 74
Query: 73 EGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAIIGATDPA 132
G W ++K + L T+G++++ ++ + + L L GAI+ +TD A
Sbjct: 75 GGLTTRWSDVRKLLAPAGVLATVGVVISVVVTAAGAHWLLGIDWRLALLIGAIVSSTDAA 134
Query: 133 TLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIY 192
+ + R + + + ++ ES FND I+L L +FST S+ G
Sbjct: 135 AVFAVLRALPLPRKVSVLVEAESGFNDAPTIILVL-------------LFSTTSDLPGPL 181
Query: 193 AGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDA 252
V L+ + V LG+ G LG ++ + ++ + F L A
Sbjct: 182 P-VVGNLLFQLVVGGVLGVVTGRLGVAALRHIALPATGLYPLATVGFGVVAFAAAGALGA 240
Query: 253 SGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAE 312
SG + A ++G+VLGN KL RA + F++ + LA I +FV+LG
Sbjct: 241 SGIIAAYLSGLVLGNAKL------------PHRAATRS--FSEGVGWLAQIGLFVMLGLL 286
Query: 313 MNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWN--FREYLFIALEGPRGVVPSALA 370
++ + S + L+V L +++LARP++ L L + +RE +FI+ G RG VP L
Sbjct: 287 VDPSELPSAILPALVVGLVLLLLARPVSVLLCLLPFRVPWREQVFISWAGLRGAVPIVLT 346
Query: 371 SLPLSLALKYKSPLLTVHWGEIIMATVV 398
+ P+ + L + + +++ T++
Sbjct: 347 TFPVVAGVTGARDALNIVFVLVVLFTLL 374
>dbj|BAA89487.1| (AB029555) NhaG Na/H antiporter [Bacillus subtilis]
Length = 524
Score = 100 bits (247), Expect = 3e-20
Identities = 112/425 (26%), Positives = 193/425 (45%), Gaps = 50/425 (11%)
Query: 29 ISYVPIFILTGLVIGPLLKLIPRDLAH-EIFDFVRVFGLVIILFTEGH-NLSWRLLKKNM 86
I+ V + + GLV PL + + + E+F+FV + + L E L + L++N
Sbjct: 36 IALVIVGTIIGLVHIPLFEPLKEFITEGEVFNFVIITLFLPALLGEAALKLPFSHLRENK 95
Query: 87 PTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAIIGATDPATLIPLFRQYRVKQD 146
++ L G +++ LI GF + + + F+F A++ ATDP +++ +F+ +
Sbjct: 96 RPVLALFG-GTLISFLIVGFSSMWLMHLAIPAAFVFAALMSATDPVSVLSIFKSVGAPKK 154
Query: 147 IETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVS 206
+ V+ ES+FND L +VL I+ L+ LGI G+ L+
Sbjct: 155 LSIVVEGESLFNDGLAVVLFNISAFYLMTYL----------DLGIQGAGL--GLWEFVKV 202
Query: 207 ISLGIFL-GILGYKFIKRTGIF-DFPEIEAFSLSLAFLGFFIGERLDASGYLVATVTGIV 264
ISLG+ + G+LGY F + T F D+P FS+ L + F + E ASG + V ++
Sbjct: 203 ISLGLIIGGVLGYVFSQLTKYFDDYPLEIIFSIILFYSSFLLAEMAGASGVIAVVVAALI 262
Query: 265 LGNYKL---LKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSN 321
GNY + P + I +F D A LA +F+++G E+ +
Sbjct: 263 FGNYGAKIGMSPTTKLNI-----------NNFWDVAALLANSLVFLMVGLEITRIDLTDK 311
Query: 322 LGKGLLVALGVMILARPLA---TLPLLKWWNFREYLFIALEGPRGVVPSALASLPLSLAL 378
G ++ A+ ++++AR A +L +K + I G +G + S+ L L+L
Sbjct: 312 WGLAIM-AIVIVLIARSAAVYISLAFIKKFPVTWKHTINWGGLKGSL-----SIALVLSL 365
Query: 379 KYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIKERIEEKEEEKER 438
P E I+ VL S++V+ L I L ++L V + EE +E E
Sbjct: 366 PRDFP-----GREDILVFAFSVVLFSLVVQGLTIKPLLERLGVNQK-----EEGNQEYEE 415
Query: 439 RKVRG 443
+G
Sbjct: 416 LLAKG 420
>sp|P76007|YCGO_ECOLI PUTATIVE NA(+)/H(+) EXCHANGER YCGO
Length = 578
Score = 99.8 bits (245), Expect = 5e-20
Identities = 99/375 (26%), Positives = 168/375 (44%), Gaps = 37/375 (9%)
Query: 12 LILFTGVISMLISRRTGISYVPIFILTGLVIG-PLLKLIPRDLAHEIFDFVRVFGLVIIL 70
+++ + ++ S R GI + IF+ G++ G + IP D + V L IIL
Sbjct: 15 ILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFD-NYPFAYMVSNLALAIIL 73
Query: 71 FTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAIIGATD 130
G + + ++L T+G+++T+ + G + +FN + G L GAI+G+TD
Sbjct: 74 LDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTD 133
Query: 131 PATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLG 190
A + L + + + + + ES NDP+ + LT+ I+M+ S +S
Sbjct: 134 AAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQHHE-----SNIS---- 184
Query: 191 IYAGGVIYFLYNVSVSISLGIFLGI-LGYKFIKRTGIFDFPE--IEAFSLSLAFLGFFIG 247
F+ ++ LGI +G+ GY ++ P +LS L F +
Sbjct: 185 ------WMFIVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFSLT 238
Query: 248 ERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFV 307
L+ SG L + G +LGN + R IL+ D LA LA I +F+
Sbjct: 239 TALEGSGILAVYLCGFLLGNRPI---RNRYGILQNF-----------DGLAWLAQIAMFL 284
Query: 308 LLGAEMNLEVIWSNLGKGLLVALGVMILARPL---ATLPLLKWWNFREYLFIALEGPRGV 364
+LG +N + L+++ ++ ARPL A L + +N RE +FI+ G RG
Sbjct: 285 VLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWVGLRGA 344
Query: 365 VPSALASLPLSLALK 379
VP LA P+ L+
Sbjct: 345 VPIILAVFPMMAGLE 359
>gi|6320663 Na+/H+ exchanger; Nhx1p [Saccharomyces cerevisiae]
>gi|6919935|sp|Q04121|NAH2_YEAST MITOCHONDRIAL
SODIUM/HYDROGEN EXCHANGER (MITOCHONDRIAL NA(+)/H(+)
EXCHANGER) >gi|2131504|pir||S69734 hypothetical protein
YDR456w - yeast (Saccharomyces cerevisiae)
>gi|927695|gb|AAB64861.1| (U33007) Ydr456wp; CAI: 0.16
[Saccharomyces cerevisiae]
Length = 633
Score = 98.7 bits (242), Expect = 1e-19
Identities = 113/447 (25%), Positives = 195/447 (43%), Gaps = 71/447 (15%)
Query: 3 ELSLAEALFLILFTGVISMLIS------RRTGISYVPIFILTGLVIGPLLKLIPRDLAHE 56
E+ + ALF++L + ++ S R + + I G+VIG ++++ P +
Sbjct: 57 EMFSSWALFIMLLLLISALWSSYYLTQKRIRAVHETVLSIFYGMVIGLIIRMSPGHYIQD 116
Query: 57 I--FDFVRVFGLVI--ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKV-- 110
F+ F +++ I+ G+ L+ NM +I+ G ++A++ G I +
Sbjct: 117 TVTFNSSYFFNVLLPPIILNSGYELNQVNFFNNMLSILIFAIPGTFISAVVIGIILYIWT 176
Query: 111 -----VFNSSFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVL 165
+ SF GA + ATDP T++ +F Y+V + T+I ES+ ND + IV+
Sbjct: 177 FLGLESIDISFADAMSVGATLSATDPVTILSIFNAYKVDPKLYTIIFGESLLNDAISIVM 236
Query: 166 TLIAISMLVPGYG-GGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRT 224
+G FS++ E G+ FL SVS+ +G+ +GIL +K T
Sbjct: 237 ----FETCQKFHGQPATFSSVFEGAGL-------FLMTFSVSLLIGVLIGILVALLLKHT 285
Query: 225 GIFDFPEIEA-FSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRL 283
I +P+IE+ L +A+ +F SG + GI L +Y + +R
Sbjct: 286 HIRRYPQIESCLILLIAYESYFFSNGCHMSGIVSLLFCGITLKHYAY------YNMSRRS 339
Query: 284 QRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLP 343
Q I+ + LA L+ FIF+ LG E+ EV ++VA + +AR A P
Sbjct: 340 QITIK---YIFQLLARLSENFIFIYLGLELFTEVELVYKPLLIIVAAISICVARWCAVFP 396
Query: 344 LLKW--WNFREYLFIALEGPRG---VVPSAL------------------ASLPLSLALKY 380
L ++ W +R ++ G G VP + +L L + +Y
Sbjct: 397 LSQFVNWIYRVKTIRSMSGITGENISVPDEIPYNYQMMTFWAGLRGAVGVALALGIQGEY 456
Query: 381 KSPLLTVHWGEIIMATVVITVLTSVIV 407
K LL ATV++ V+ +VI+
Sbjct: 457 KFTLL---------ATVLVVVVLTVII 474
>pir||G83177 probable sodium/hydrogen antiporter PA3739 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9949907|gb|AAG07126.1|AE004793_3 (AE004793) probable
sodium/hydrogen antiporter [Pseudomonas aeruginosa]
Length = 611
Score = 98.3 bits (241), Expect = 2e-19
Identities = 106/403 (26%), Positives = 181/403 (44%), Gaps = 50/403 (12%)
Query: 18 VISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIFDFVRVFGLVIILFTEG--- 74
++S ++ R + + +L+G+V GPLL + D F V V ++ EG
Sbjct: 18 LLSQWLAWRLRLPAILFLLLSGIVAGPLLGWLDPDEMFGPLLFPLVSLAVALILFEGSLT 77
Query: 75 -HNLSWR---LLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAIIGATD 130
H W+ + M TI L T G+I AL A ++ + S+ + LFG + T
Sbjct: 78 LHFSEWKEIGTVVHRMVTIGALSTWGVI--ALAAHYLL----DFSWEMALLFGTLTLVTG 131
Query: 131 PATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLV-PGYGGGIFSTLSEKL 189
P ++P+ R R K + ++ E I DP+G +L ++ S ++ G G G +L
Sbjct: 132 PTVIVPMLRVVRPKAAVANILRWEGIVIDPIGALLAVVVYSFIISSGEGDGWLHSLQTFG 191
Query: 190 GIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGER 249
G+ G ++ I G LGI+ ++R + D+ + + A LG FI
Sbjct: 192 GVILCGSLF-------GILGGWALGIV----LRRHWLPDY--LHNLATLAAVLGVFIASN 238
Query: 250 --LDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFV 307
+ SG L T+ G+ L N K + R+ + HF + L+ L +F+
Sbjct: 239 RVMHESGLLAVTLMGMGLANMKGVDVRQIL--------------HFKENLSVLLISGLFI 284
Query: 308 LLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKW---WNFREYLFIALEGPRGV 364
LL A +++ + LLV L + +ARPL + L W ++RE ++ PRG+
Sbjct: 285 LLAARLDINALLGLGPAALLVLLLIQFVARPL-NVALSTWGSPLSWRERALLSWIAPRGI 343
Query: 365 VP---SALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTS 404
V SA+ ++ LS ++ LL +I+ TVV+ T+
Sbjct: 344 VAAAVSAIFAIRLSAEGHAQAALLVPLTFLVIIGTVVLQSATA 386
>pir||A83018 probable sodium/hydrogen antiporter PA5021 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951309|gb|AAG08406.1|AE004915_1 (AE004915) probable
sodium/hydrogen antiporter [Pseudomonas aeruginosa]
Length = 538
Score = 96.7 bits (237), Expect = 5e-19
Identities = 88/338 (26%), Positives = 153/338 (45%), Gaps = 33/338 (9%)
Query: 66 LVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAI 125
L +IL G + + ++L T+G+++T + G +F+ ++ G L GAI
Sbjct: 27 LAVILLDGGLRTRVSSFRVALWPALSLATLGVLVTTGLTGIAAAWLFDLHWMEGLLIGAI 86
Query: 126 IGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTL 185
+G+TD A + L + + + + ES NDP+ + LT+ I ML G
Sbjct: 87 VGSTDAAAVFSLLGGKGLNERVTATLEIESGSNDPMAVFLTVTLIEMLASG--------- 137
Query: 186 SEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFD--FPEIEAFSLSLAFLG 243
+ G+ G ++ + + LG+ G L + I R + +P +S L
Sbjct: 138 --QTGLSWGFALHLVQQFGLGALLGLGGGWLLLQLINRMHLAGGLYP---LLVISGGLLV 192
Query: 244 FFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATI 303
F + + SG L + G++LGN + ++ R I +H D +A LA I
Sbjct: 193 FALANAVGGSGILAIYLCGLLLGN-RPIRSRHGI-------------LHMLDGMAWLAQI 238
Query: 304 FIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLL---KWWNFREYLFIALEG 360
+F++LG + +W L +AL ++++ARPL+ L L + ++ RE FIA G
Sbjct: 239 GMFLVLGLLVTPHDLWPIALPALALALWMILVARPLSVLIGLIPFRAFHDREKAFIAWVG 298
Query: 361 PRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVV 398
RG VP LA PL L V + ++++ +V
Sbjct: 299 LRGAVPIILAVFPLMAGLPNAQLFFNVAFFIVLVSLLV 336
>pir||D64865 probable Na+/H+-exchanging protein b1191 - Escherichia coli
>gi|1787440|gb|AAC74275.1| (AE000217) orf, hypothetical
protein [Escherichia coli K12]
>gi|4062774|dbj|BAA36046.1| (D90753) ORF_ID:o245#1
[Escherichia coli] >gi|4062776|dbj|BAA36049.1| (D90754)
ORF_ID:o245#1 [Escherichia coli]
Length = 536
Score = 93.6 bits (229), Expect = 4e-18
Identities = 87/320 (27%), Positives = 144/320 (44%), Gaps = 35/320 (10%)
Query: 66 LVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAI 125
L IIL G + + ++L T+G+++T+ + G + +FN + G L GAI
Sbjct: 27 LAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAI 86
Query: 126 IGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTL 185
+G+TD A + L + + + + + ES NDP+ + LT+ I+M+ S +
Sbjct: 87 VGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQHHE-----SNI 141
Query: 186 SEKLGIYAGGVIYFLYNVSVSISLGIFLGI-LGYKFIKRTGIFDFPE--IEAFSLSLAFL 242
S F+ ++ LGI +G+ GY ++ P +LS L
Sbjct: 142 S----------WMFIVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGIL 191
Query: 243 GFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALAT 302
F + L+ SG L + G +LGN + R IL+ D LA LA
Sbjct: 192 IFSLTTALEGSGILAVYLCGFLLGNRPI---RNRYGILQNF-----------DGLAWLAQ 237
Query: 303 IFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPL---ATLPLLKWWNFREYLFIALE 359
I +F++LG +N + L+++ ++ ARPL A L + +N RE +FI+
Sbjct: 238 IAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWV 297
Query: 360 GPRGVVPSALASLPLSLALK 379
G RG VP LA P+ L+
Sbjct: 298 GLRGAVPIILAVFPMMAGLE 317
>gb|AAG20219.1| (AE005097) Vng2068c [Halobacterium sp. NRC-1]
Length = 637
Score = 92.8 bits (227), Expect = 7e-18
Identities = 93/445 (20%), Positives = 193/445 (42%), Gaps = 54/445 (12%)
Query: 13 ILFTGVISMLISRRTGISYVPIFILTGLVIGP-LLKLIPRDLAHEIFDFVRVFGL--VII 69
I+ GV+S +++ + + V IL G+V+GP +L ++ I + GL +I
Sbjct: 28 IIALGVLSQVVADKLQVPSVLFLILAGIVVGPEVLGVVTLSSFGGIDTLAGIVGLSVAVI 87
Query: 70 LFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAIIGAT 129
+F +L L++ + L T+G + + +V+ + + + FL G+++ AT
Sbjct: 88 VFEGAFHLKLEKLREAPGAWLRLVTVGAAIALFGTAIVVRVLLGTGWDVAFLIGSLLVAT 147
Query: 130 DPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKL 189
P + P+ V+ + + TE + ND +L ++ + +V + L +
Sbjct: 148 GPTVITPILSVVPVRDRVGAALETEGVVNDVTAAILAIV-VFRVVENPQRSVDVVLQD-- 204
Query: 190 GIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIF--DFPE-IEAFSLSLAFLGFFI 246
F+ + + +G+ + + + ++R + + P+ L+ A + +
Sbjct: 205 ---------FVTRLGTGVLVGLVVAAVVWYILRRIDLSKGNAPQNARLVVLAGALVAYGA 255
Query: 247 GERLDASGYLVATVT-GIVLGNYKLLKPRENIRILKRLQRAIEKEVH-FNDTLAALATIF 304
+ L + + A T G++LGN L EKE+ F + + F
Sbjct: 256 ADTLYSEAGIAAVATAGVLLGNADL---------------PYEKEIEAFKGDVTLVVLSF 300
Query: 305 IFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATL--PLLKWWNFREYLFIALEGPR 362
+F+ L A ++ + + GL VA+ V ++ RPLA + E +F++ GPR
Sbjct: 301 VFIGLAALLSFQTLLDLGVAGLAVAVLVALVIRPLAVFASTARSRYTSAERVFMSAVGPR 360
Query: 363 GVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLD-- 420
G++P+++A+L Y P +++ TV +T+L +V+ E + + L+
Sbjct: 361 GIIPASVATLFAVELQGYGMP----QAANVLVGTVFLTILLTVVFEGGFARHIAQALNVI 416
Query: 421 -----------VGETIKERIEEKEE 434
VG + ER+E++ E
Sbjct: 417 PMRVIIVGGGTVGRALAERLEDRGE 441
>pir||T37706 probable sodium/hydrogen exchanger - fission yeast
(Schizosaccharomyces pombe) >gi|3850064|emb|CAB10103.1|
(Z97208) putative sodium/hydrogen exchanger
[Schizosaccharomyces pombe]
Length = 569
Score = 91.7 bits (224), Expect = 2e-17
Identities = 83/335 (24%), Positives = 152/335 (44%), Gaps = 41/335 (12%)
Query: 3 ELSLAEALFLILFTGVISMLIS------RRTGISYVPIFILTGLVIGPLLKLIPRDLAHE 56
EL + ALF++L + ++L S + I I + G+V+G ++++ P +
Sbjct: 30 ELYSSWALFILLVLLIGALLTSYYVQSKKIRAIHETVISVFVGMVVGLIIRVSPGLIIQN 89
Query: 57 IFDFVRVFGLVIIL----FTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAG---FIFK 109
+ F + ++L G+ L +N+ TI+T G ++A+ G +IF
Sbjct: 90 MVSFHSTYFFNVLLPPIILNSGYELHQSNFFRNIGTILTFAFAGTFISAVTLGVLVYIFS 149
Query: 110 VV----FNSSFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVL 165
+ + +F+ GA + ATDP T++ +F Y+V Q + T+I ESI ND + IV+
Sbjct: 150 FLNFENLSMTFVEALSMGATLSATDPVTVLAIFNSYKVDQKLYTIIFGESILNDAVAIVM 209
Query: 166 TLIAISMLVPGYGGGI-FSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLG-ILGYKFIKR 223
L G + F TL +GI+ +I F ++ + +S+G+ +L Y +++R
Sbjct: 210 ----FETLQQFQGKTLHFFTLFSGIGIF---IITFFISLLIGVSIGLITALLLKYSYLRR 262
Query: 224 TGIFDFPEIEA-FSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKR 282
+P IE+ L +A+ +F SG + GI L +Y ++ +
Sbjct: 263 -----YPSIESCIILLMAYTSYFFSNGCHMSGVVSLLFCGITLKHYAFFNMSYKAKLSTK 317
Query: 283 LQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEV 317
+ LA L+ FIF+ LG + +V
Sbjct: 318 ---------YVFRVLAQLSENFIFIYLGMSLFTQV 343
>gb|AAB61290.1| (AF003741) unknown [Escherichia coli] >gi|3661474|gb|AAC61706.1|
(AF081283) F536 [Escherichia coli]
Length = 536
Score = 90.5 bits (221), Expect = 4e-17
Identities = 86/321 (26%), Positives = 143/321 (43%), Gaps = 37/321 (11%)
Query: 66 LVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGAI 125
L IIL G + ++L T+G+++T+ + G + +FN + G L GAI
Sbjct: 27 LAIILLDGGMRTQASSFCVALGPALSLATLGVLITSGLTGMMAGWLFNLDLIEGLLIGAI 86
Query: 126 IGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTL 185
+G+TD A + L + + + + + ES NDP+ + LT+ I+M+
Sbjct: 87 VGSTDAAAVFFLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQQ---------- 136
Query: 186 SEKLGIYAGGVIY-FLYNVSVSISLGIFLGI-LGYKFIKRTGIFDFPE--IEAFSLSLAF 241
+ V + F+ ++ LGI +G+ GY ++ P +LS
Sbjct: 137 ------HESSVSWMFVVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGI 190
Query: 242 LGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALA 301
L F + L+ SG L + G +LGN + R IL+ D LA LA
Sbjct: 191 LIFALTTALEGSGILAVYLCGFLLGNRPI---RNRYGILQNF-----------DGLAWLA 236
Query: 302 TIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPL---ATLPLLKWWNFREYLFIAL 358
I +F++LG +N + L+++ ++ ARPL A L + +N RE +FI+
Sbjct: 237 QIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISW 296
Query: 359 EGPRGVVPSALASLPLSLALK 379
G RG VP LA P+ L+
Sbjct: 297 VGLRGAVPIILAVFPMMAGLE 317
>pir||F82291 conserved hypothetical protein VC0689 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9655129|gb|AAF93854.1|
(AE004155) conserved hypothetical protein [Vibrio
cholerae]
Length = 599
Score = 90.5 bits (221), Expect = 4e-17
Identities = 97/417 (23%), Positives = 185/417 (44%), Gaps = 48/417 (11%)
Query: 1 MIELSLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLI-PRDLAHEIFD 59
M E S+A + + G+ ++ R + + +L G++ GP+ ++ P L ++
Sbjct: 2 MHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLF 61
Query: 60 FVRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLG 119
+ + +ILF L+++ ++ T+ ++ T+G +++ I + + L
Sbjct: 62 PLVSLAVAVILFEGSLTLNFKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLA 121
Query: 120 FLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGG 179
+FG++ T P ++PL R R + ++ E I DPLG + ++ +V
Sbjct: 122 LMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILIDPLGALFVVMVYEFIVS---- 177
Query: 180 GIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPE-IEAFSLS 238
S+ + L +++ + L S+ I+ G+ + + R G+ PE ++ F++
Sbjct: 178 ---SSHAHSLEVFS---LILLVGFSIGIASGVAVAA-----VLRRGL--LPEYLQPFAVL 224
Query: 239 LAFLGFFIGERL--DASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDT 296
LG F SG L TV G+ L N K + I+ +HF +
Sbjct: 225 SVVLGVFAASNALESESGLLTVTVMGMWLANAKGVN--------------IQHILHFKEH 270
Query: 297 LAALATIFIFVLLGAEMNL----EVIWSNLGKGLLVALGVMILARPLATL--PLLKWWNF 350
L L +F+LL A + + + WS L GL V + +LARP + L N
Sbjct: 271 LTILLITGLFILLAARIEVADFQALGWSAL--GLFVVM--QLLARPASIFISTLRSTLNV 326
Query: 351 REYLFIALEGPRGVVPSALASLPLSLALKY---KSPLLTVHWGEIIMATVVITVLTS 404
RE F+A PRG+V ++++SL +++ + LL +I+ TVV+ T+
Sbjct: 327 REKAFLAWVAPRGIVAASISSLFAIKLMEFGIADAKLLVPLTFMVIIGTVVLQSATA 383
>emb|CAB94669.1| (AL359217) possible Na+/H+ antiporter [Leishmania major]
Length = 1500
Score = 88.2 bits (215), Expect = 2e-16
Identities = 104/427 (24%), Positives = 193/427 (44%), Gaps = 41/427 (9%)
Query: 2 IELSLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIF--- 58
+ L + LI G M RR + Y + L G+V+G + + + D+A +
Sbjct: 31 LSLVILFVTMLIFLGGTFFMTHKRRIPLPYTVVLFLYGIVVGVVSRWLYPDVAEALGSIP 90
Query: 59 -DFVRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNS-SF 116
+ + L +++F + ++ L++ P + L T+G+++ + K+ F + S+
Sbjct: 91 PELLFYIFLPVLIFEGSYAMNIHALRRVFPQVALLATVGVLINTALLAVPVKLFFQTWSW 150
Query: 117 LLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPG 176
L G+++ ATDP ++ L ++ V + + ++ E++ ND I+L ++L+P
Sbjct: 151 YTALLLGSLLSATDPVAVVALLKELGVDKCMTAMVDGEAVMNDGTAIIL----FTLLLPA 206
Query: 177 YGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFS 236
G F +S G+ V+ ++ + I+LG G L +++RT D +
Sbjct: 207 ARVG-FVDMSP--GVI---VVRCIWLALLPIALGPLFGFLQSFWLRRTS--DGLTKACIT 258
Query: 237 LSLAFLGFFI-GERLDASGYLVATVTGIVLGNY--KLLKPRENIRILKRLQRAIEKEVHF 293
+S+ ++ +++ E L SG L GI L Y L RE+ + A E VH
Sbjct: 259 VSVTYVSYYVAAEMLGTSGVLTLFFQGIFLSYYCPSLFPGRES----NIISSAWEFLVHL 314
Query: 294 NDTLAALATIFIFVLLGAEMNLEVI--WSNLGKGLLVALGV-MILARPLATLPLLKWWNF 350
+T+ +F L+G + +V+ L +LVAL + M+L+R L L N
Sbjct: 315 GNTV-------LFSLVGVILVADVLPTVKLLDIFVLVALYIAMMLSRLLMLEVLSPVLNM 367
Query: 351 REYLF----IAL---EGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLT 403
Y F IAL G RG V + LA + L+ +L V G +++ +V +
Sbjct: 368 FSYKFDQKRIALMVHAGLRGGVAATLAIAVMQEGLEEGVDILKVTSGIVLLTLLVNASTS 427
Query: 404 SVIVETL 410
+ +VE L
Sbjct: 428 ATVVERL 434
>pir||S76231 Na+/H+-exchanging protein sll0273 - Synechocystis sp. (strain PCC
6803) >gi|1653577|dbj|BAA18490.1| (D90914) Na+/H+
exchanger [Synechocystis sp.]
Length = 540
Score = 86.6 bits (211), Expect = 5e-16
Identities = 101/426 (23%), Positives = 185/426 (42%), Gaps = 47/426 (11%)
Query: 5 SLAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPRDLAHEIF-DFVRV 63
+L E L ++L + L++R I YV +L GL I PR L+ + + +
Sbjct: 31 TLVENLIILLLVATLVALVARWLKIPYVIGLVLAGLAI-------PRGLSVGLNPELILN 83
Query: 64 FGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFG 123
F L I++F N L+ + I L G++++A I + K+ +++
Sbjct: 84 FFLPILIFEAAINTDISRLRSTIKPITVLAGPGVVISAAITAVLLKIGLGLAWVTAAGVS 143
Query: 124 AIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFS 183
I+ TD ++I FR V + + T++ ES+ ND + +VL + ++ + G
Sbjct: 144 VILTITDTVSVIAAFRSVPVPRRLATIVEGESMLNDGVAMVLLSVITTIHIQG------- 196
Query: 184 TLSEKLGIYAGGVIYFLYNVSVSISL-GIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFL 242
G AG I ++ V L G+ LG L ++ D +I ++S++
Sbjct: 197 ------GFSAGEGIRQIFVAFVGGGLVGLGLGYLCVGLFRQLN-DDLSDI-LLTVSVSLG 248
Query: 243 GFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALAT 302
F IG+ L S + V G+V+GN L + +I++ + F +
Sbjct: 249 TFQIGQMLGVSSAIAVVVAGLVIGNLALKQTSASIKVTL---------LSFWEYAGFGVN 299
Query: 303 IFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFREYLFIALEGP- 361
IF+L+G E+ ++ S + L+A+ + R + PLL YL + P
Sbjct: 300 TLIFLLVGIEVYPSILLSTI-PAALIAIVAYQIGRVFSIYPLL-------YLLSFFDRPL 351
Query: 362 ----RGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKD 417
+ V+ + LS+AL P LT+ + ++ V TV+ S+I + L +P +
Sbjct: 352 PLRWQHVLIAGNVKGSLSMALALALP-LTLPGRDQVVTLVFSTVMVSLIGQGLSLPWVVK 410
Query: 418 KLDVGE 423
KL + +
Sbjct: 411 KLQLSK 416
>gb|AAF52423.2| (AE003614) Nhe3 gene product [Drosophila melanogaster]
Length = 727
Score = 86.6 bits (211), Expect = 5e-16
Identities = 88/336 (26%), Positives = 149/336 (44%), Gaps = 40/336 (11%)
Query: 58 FDFVRVFGLVI--ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTA-LIAGFIFKVV--- 111
FD F +++ I+F G++L + +N+ I+T +G L+A LI GF++ V
Sbjct: 196 FDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLM 255
Query: 112 -----FNSSFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLT 166
+ +FL FGA+I TDP T++ +F RV ++ +++ ES+ ND + IVL
Sbjct: 256 PKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVL- 314
Query: 167 LIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGI 226
S + YG +T + + + F +S+ +G +G L K T +
Sbjct: 315 ----SGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRV 370
Query: 227 FDFPEIE-AFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQR 285
DFP +E A + +++ F + E + +G + GI +Y E+ R
Sbjct: 371 RDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSR------- 423
Query: 286 AIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLV------ALGVMILARPL 339
++ + L LA FIF +G M + G ++ A+G + PL
Sbjct: 424 --QRTKQIFELLNFLAENFIFSYIGVSM-FTFPKHHFDAGFIITAFICAAIGRAVNVYPL 480
Query: 340 ATLPLLK-----WWNFREYLFIALEGPRGVVPSALA 370
+ L +K NF+ LF A G RG + ALA
Sbjct: 481 SWLLNIKRKPKISTNFQHMLFFA--GLRGAMSFALA 514
>pir||H75278 probable Na+/H+ antiporter - Deinococcus radiodurans (strain R1)
>gi|6460212|gb|AAF11941.1|AE002070_3 (AE002070) Na+/H+
antiporter, putative [Deinococcus radiodurans]
Length = 458
Score = 85.8 bits (209), Expect = 9e-16
Identities = 95/366 (25%), Positives = 149/366 (39%), Gaps = 31/366 (8%)
Query: 59 DFVRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGF----IFKVV-FN 113
DFV L I+LF L R L + +I+TL +L+ + GF IF +V N
Sbjct: 84 DFVLNGILSILLFAGALGLDARQLLRQRFSILTLAVFSTLLSTFLIGFAAYGIFGLVGLN 143
Query: 114 SSFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISML 173
L LFGA+I TDP ++ L ++ V + IET+I ES+FND +G+V+ L+ M
Sbjct: 144 VPLLWSLLFGALISPTDPVAVLDLLKRAAVPKRIETLIAGESLFNDGVGVVIFLVIAGMA 203
Query: 174 VPGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIE 233
G+ G G G + F ++ G LG +G+ ++ I
Sbjct: 204 GIGHSHG--------TGSVVGALELFGREALGGMAFGALLGAIGFLMLRE--IEQHAVEV 253
Query: 234 AFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHF 293
+L+L G+ L SG L V G+V+ + + E R E F
Sbjct: 254 LITLALVVGGYVAASALGVSGPLAMVVAGLVISAGRDVAFGEETR---------EHIESF 304
Query: 294 NDTLAALATIFIFVLLGAEMNL-EVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFRE 352
+T + I +F +G ++ L E + GLL+ + ++ LP +
Sbjct: 305 WETTDQVLNILLFAFIGLDVLLTETTGPQIVAGLLLVVASLLARWISVALPFPLIRRHED 364
Query: 353 YLFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWI 412
Y GP V L +A+ L + ++ I VL S+ V+ L I
Sbjct: 365 Y------GPYTVRLLTWGGLRGGIAISLVLGLPQTPYRTHLVTATYIIVLFSIAVQGLTI 418
Query: 413 PILKDK 418
L K
Sbjct: 419 MPLVHK 424
>gb|AAD32689.1|AF142676_1 (AF142676) sodium-hydrogen exchanger NHE1 [Drosophila melanogaster]
Length = 561
Score = 85.0 bits (207), Expect = 2e-15
Identities = 105/441 (23%), Positives = 184/441 (40%), Gaps = 75/441 (17%)
Query: 13 ILFTGVISMLISRRTGISYVP---IFILTGLVIGPLLKLIPRDLA----HEIFDFVRVFG 65
++ G++ + +TG Y+P + + G IG L ++ E+F + F
Sbjct: 110 VIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMSGQNGSWKREEVFSPMGFFL 169
Query: 66 LVI--ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGF------IFKVVFNSSFL 117
+++ I+F G+NL +N+ +I+ G ++AL+ G + +V F SF
Sbjct: 170 VLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAFRLSFS 229
Query: 118 LGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTL-IAISMLV-- 174
F FG++I A DP + +F V + ++ ESI ND + IVLT I S V
Sbjct: 230 ESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNA 289
Query: 175 -PGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIE 233
G +FS L F S +G+ ++ +K + P +E
Sbjct: 290 EASTGEAMFSALKT-----------FCAMFFASAGIGVIFALISALLLKHIDLRKHPSLE 338
Query: 234 -AFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVH 292
A L + + + E + SG + GIV+ +Y + + Q +++ +
Sbjct: 339 FAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHY------THFNLSTVTQITMQQTMR 392
Query: 293 FNDTLAALATIFIFVLLG---------AEMNLEVIWSNLGKGLLVALGVMILARPLATLP 343
TLA +A +F LG E++ VIW A+ + ++ R P
Sbjct: 393 ---TLAFIAETCVFAYLGLAIFSFKHQVELSF-VIW---------AIVLCLIGRACNIFP 439
Query: 344 LLKWWN-FREY-------LFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMA 395
L N FRE+ + G RG + AL SL L+L + K + II
Sbjct: 440 LAFLVNKFREHKINNKMQFIMWFSGLRGAISYAL-SLHLNLDSQEKRHV-------IITT 491
Query: 396 TVVITVLTSVIVETLWIPILK 416
T++I + T++++ +P+LK
Sbjct: 492 TLIIVLFTTLVLGGSTMPLLK 512
>gb|AAF13702.1|AF199463_1 (AF199463) sodium-hydrogen exchanger NHE3 [Drosophila melanogaster]
Length = 687
Score = 85.0 bits (207), Expect = 2e-15
Identities = 88/336 (26%), Positives = 148/336 (43%), Gaps = 40/336 (11%)
Query: 58 FDFVRVFGLVI--ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTA-LIAGFIFKVV--- 111
FD F +++ I+F G+ L + +N+ I+T +G L+A LI GF++ V
Sbjct: 156 FDPEVFFNIILPPIIFYAGYCLKKKYFFRNLGAILTFAIVGTTLSAFLIGGFMYGCVKLM 215
Query: 112 -----FNSSFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLT 166
+ +FL FGA+I TDP T++ +F RV ++ +++ ES+ ND + IVL
Sbjct: 216 PKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAIVL- 274
Query: 167 LIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGI 226
S + YG +T + + + F +S+ +G +G L K T +
Sbjct: 275 ----SGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFTRV 330
Query: 227 FDFPEIE-AFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQR 285
DFP +E A + +++ F + E + +G + GI +Y E+ R
Sbjct: 331 RDFPLLESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSR------- 383
Query: 286 AIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLV------ALGVMILARPL 339
++ + L LA FIF +G M + G ++ A+G + PL
Sbjct: 384 --QRTKQIFELLNFLAENFIFSYIGVSM-FTFPKHHFDAGFIITAFICAAIGRAVNVYPL 440
Query: 340 ATLPLLK-----WWNFREYLFIALEGPRGVVPSALA 370
+ L +K NF+ LF A G RG + ALA
Sbjct: 441 SWLLNIKRKPKISTNFQHMLFFA--GLRGAMSFALA 474
>gb|AAF51559.1| (AE003590) Nhe1 gene product [Drosophila melanogaster]
Length = 649
Score = 85.0 bits (207), Expect = 2e-15
Identities = 105/441 (23%), Positives = 184/441 (40%), Gaps = 75/441 (17%)
Query: 13 ILFTGVISMLISRRTGISYVP---IFILTGLVIGPLLKLIPRDLA----HEIFDFVRVFG 65
++ G++ + +TG Y+P + + G IG L ++ E+F + F
Sbjct: 110 VIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMSGQNGSWKREEVFSPMGFFL 169
Query: 66 LVI--ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGF------IFKVVFNSSFL 117
+++ I+F G+NL +N+ +I+ G ++AL+ G + +V F SF
Sbjct: 170 VLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAFRLSFS 229
Query: 118 LGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTL-IAISMLV-- 174
F FG++I A DP + +F V + ++ ESI ND + IVLT I S V
Sbjct: 230 ESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNA 289
Query: 175 -PGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIE 233
G +FS L F S +G+ ++ +K + P +E
Sbjct: 290 EASTGEAMFSALKT-----------FCAMFFASAGIGVIFALISALLLKHIDLRKHPSLE 338
Query: 234 -AFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVH 292
A L + + + E + SG + GIV+ +Y + + Q +++ +
Sbjct: 339 FAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHY------THFNLSTVTQITMQQTMR 392
Query: 293 FNDTLAALATIFIFVLLG---------AEMNLEVIWSNLGKGLLVALGVMILARPLATLP 343
TLA +A +F LG E++ VIW A+ + ++ R P
Sbjct: 393 ---TLAFIAETCVFAYLGLAIFSFKHQVELSF-VIW---------AIVLCLIGRACNIFP 439
Query: 344 LLKWWN-FREY-------LFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMA 395
L N FRE+ + G RG + AL SL L+L + K + II
Sbjct: 440 LAFLVNKFREHKINNKMQFIMWFSGLRGAISYAL-SLHLNLDSQEKRHV-------IITT 491
Query: 396 TVVITVLTSVIVETLWIPILK 416
T++I + T++++ +P+LK
Sbjct: 492 TLIIVLFTTLVLGGSTMPLLK 512
>gb|AAG38538.1|AF309805_3 (AF309805) putative Na+/H+ exchanger Nhx1 [Pneumocystis carinii f.
sp. carinii]
Length = 560
Score = 83.5 bits (203), Expect = 5e-15
Identities = 79/292 (27%), Positives = 130/292 (44%), Gaps = 31/292 (10%)
Query: 34 IFILTGLVIGPLLKLIPRDLAHEI--FDFVRVFGLVI--ILFTEGHNLSWRLLKKNMPTI 89
I IL G+++G L+K I +I F++ F L++ I+ G+ L L KN I
Sbjct: 49 ISILLGMIVGVLIKEIKNTDIQKIVTFNYGYFFNLLLPPIILNSGYELHQELFFKNAGAI 108
Query: 90 VTLDTIGLILTALIAGFIFKV-------VFNSSFLLGFLFGAIIGATDPATLIPLFRQYR 142
T +G ++A+I G + + S++ FGA I ATDP T++ +FR Y
Sbjct: 109 FTFAFVGTFVSAVITGLLIYLWALTGLEQIGISWIEALKFGATISATDPVTILSIFRTYN 168
Query: 143 VKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLYN 202
V + T+I ES+ ND + IV+ L Y + S + +GI +I+
Sbjct: 169 VDPTLYTIIFGESLLNDSVSIVM----FETLQRFYNKEM-SIIDVFIGIGRFFIIFI--- 220
Query: 203 VSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSL-AFLGFFIGERLDASGYLVATVT 261
+S+++GI GI +K + + FP IE+ ++L A+ + SG +
Sbjct: 221 --ISLTIGIIAGISIALLLKYSHLRRFPYIESCIITLIAYSSYLFSNGCHMSGIVSLLFC 278
Query: 262 GIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAEM 313
I L +Y +Q + F L+ L+ FIFV LG +
Sbjct: 279 AITLKHYAFYN--------MSIQTQFSTKFLFK-ILSQLSENFIFVYLGISL 321
>pir||T26529 hypothetical protein Y18D10A.6 - Caenorhabditis elegans
>gi|3979941|emb|CAA22320.1| (AL034393) contains
similarity to Pfam domain: PF00999 (Sodium/hydrogen
exchanger family), Score=354.0, E-value=5.3e-103, N=1
[Caenorhabditis elegans]
Length = 703
Score = 81.5 bits (198), Expect = 2e-14
Identities = 104/419 (24%), Positives = 173/419 (40%), Gaps = 48/419 (11%)
Query: 9 ALFLILF-----TGVISMLISRRTGISYVP---IFILTGLVIGPLLKLIPRDLAHEIFDF 60
A+F ILF T V+ MLI + I ++P + G +IG +L RD +
Sbjct: 133 AIFFILFVIMLATLVVHMLIVSK--IHWMPESLAIVALGALIGSILSYSRRDWSEIEALS 190
Query: 61 VRVFGLVI---ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGF------IFKVV 111
VF LV+ I+F +NL+ N I+T G ++A++ G ++
Sbjct: 191 PDVFFLVLLPPIIFENAYNLNKGYFFSNFVPILTFAIFGTTISAMVIGAGLYILGAIGLI 250
Query: 112 FNSSFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAIS 171
F +F F F A+I A DP + +F+ +V+ + ++ ES+ ND + IVL A+
Sbjct: 251 FEFTFFECFAFAAMISAVDPVGTLAIFQAVKVESLLYMLVFGESMLNDAVSIVLAATALR 310
Query: 172 MLVPGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPE 231
P F++L I + F S LG+ +G+L K + P
Sbjct: 311 HAKPS-----FNSLPAS-EIITSAFVTFTEMFFFSACLGVGIGLLSALLFKHVDLRKTPS 364
Query: 232 IE-AFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKE 290
+E A L +++ + E LD SG + GI + + R N+ + ++
Sbjct: 365 LEFALLLIFSYIPYGFAEALDLSGIMAILFCGISMSQF----TRHNVSPIAQITFR---- 416
Query: 291 VHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLV-ALGVMILARPLATLPLLKWWN 349
H T++ +A F +G M I N L+ ++ + +L R PL N
Sbjct: 417 -HTFRTISFVAETSTFAYIG--MAFFTIKLNFAPWLIFWSVVLCLLGRACNVFPLAYLVN 473
Query: 350 ---------FREYLFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVI 399
+ + + G RG V AL L + L + KS LLT I+ T+ +
Sbjct: 474 QCRKDVQISMKNQIIMWFSGMRGAVCFALV-LYMDLDKEKKSILLTTVLFLILFTTIFL 531
>pir||T22848 hypothetical protein F57C7.2 - Caenorhabditis elegans
>gi|3877723|emb|CAA93476.1| (Z69646) contains similarity
to Pfam domain: PF00999 (Sodium/hydrogen exchanger
family), Score=596.2, E-value=6.3e-176, N=1~cDNA EST
yk249c8.5 comes from this gene~cDNA EST yk255a8.5 comes
from this gene~cDNA EST yk155d4.5 comes from this
gene~cDNA EST>
Length = 629
Score = 80.8 bits (196), Expect = 3e-14
Identities = 89/385 (23%), Positives = 162/385 (41%), Gaps = 39/385 (10%)
Query: 69 ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGF------LF 122
I+F G++L R +N+ +I+ + IG ++ G + VF S F +G+ F
Sbjct: 171 IIFNAGYSLKKRHFFRNIGSILAIVFIGTTISCFGTGCLM-FVFTSIFQMGYSFKELLFF 229
Query: 123 GAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIF 182
GA+I ATDP T+I +F V+ D+ +I ES ND + IVL+ + + F
Sbjct: 230 GALISATDPVTIISVFNDMNVEADLFALIFGESALNDAVAIVLSEVIEN----------F 279
Query: 183 STLSEKLGI--YAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIE-AFSLSL 239
ST SE + + + + F S+ LG +G + K T I + +E + + +
Sbjct: 280 STSSEAITLQDFGSAIAGFAGVFFGSLMLGFMIGCMNAFLTKMTLISEHALLESSLFVLI 339
Query: 240 AFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAA 299
+++ F + E +G + GI +Y N+ + HF ++
Sbjct: 340 SYISFLVAEVCGLTGIVSVLFCGIAQAHYTY----NNLS-----DESQSNTKHFFHMVSF 390
Query: 300 LATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKWWNFRE------- 352
+ FIF +G + + LL +L + +R L PL N R
Sbjct: 391 IMESFIFCYIGVSVFVTNNQRWSFSFLLFSLISITASRALFVYPLSWLLNIRRRPKIPKR 450
Query: 353 -YLFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLW 411
I G RG + ALA + + + + + +I+ +V LTS +++ L
Sbjct: 451 YQHMILFAGLRGAMAFALAG--RNTSTENRQMIFATTTAVVIVTVLVNGGLTSWMIDYLQ 508
Query: 412 IPILKDKLDVGETIKERIEEKEEEK 436
I KD ++ G+ ++ + ++
Sbjct: 509 IKHGKDAIEEGQRLENSMSSSPADQ 533
>gi|10957419 Na+/H+ antiporter, putative [Deinococcus radiodurans]
>gi|7473583|pir||C75631 probable Na+/H+ antiporter -
Deinococcus radiodurans (strain R1)
>gi|6460848|gb|AAF12552.1|AE001826_21 (AE001826) Na+/H+
antiporter, putative [Deinococcus radiodurans]
Length = 422
Score = 78.8 bits (191), Expect = 1e-13
Identities = 109/425 (25%), Positives = 179/425 (41%), Gaps = 60/425 (14%)
Query: 13 ILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKL--------IPRDLAHEIFDFVRVF 64
+ F V + + G++ + I LV+ LK+ + R + + F F V
Sbjct: 17 LAFLNVRVLHLPAAIGVTVGGLLISLLLVVLTALKVPFAQEAVELVRKIQFDEFVFQGVL 76
Query: 65 GLVII---LFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVV----FNSSFL 117
++ L + H L WRL + T+ L + L TAL+ G + ++ +
Sbjct: 77 SFLLFAGALSVDTHAL-WRL--RGPVTVFALLSTALS-TALVGGGTYLLLELVGLPTPLA 132
Query: 118 LGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGY 177
LFGA+I TDP ++ + ++ V IET++ ES+FND +G+V A S+L
Sbjct: 133 YCLLFGALISPTDPVAVLGMLKEAHVPSRIETLVAGESLFNDGVGVV----AFSVLA--- 185
Query: 178 GGGIFSTLSEKLGIYAGGVI-YFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFS 236
G S + AGGV+ +FL + LG FLG LG+ +KR + DF +
Sbjct: 186 GVAASSAAGHGPELSAGGVLRFFLQEAGGGLLLGGFLGWLGFLALKR--VDDFVTEVLLT 243
Query: 237 LSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDT 296
L + I L SG L A G+++G+ +P + EK F
Sbjct: 244 LGVVMACTAIATHLHVSGPLAAVAAGLLMGSLTDWRP--------GALSSREKFDSFWHL 295
Query: 297 LAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATL----PLLKWWNFRE 352
L I +F LL E+ ++ L+AL +++LAR ++ + L + F
Sbjct: 296 TDELLNISLFSLLALEIVAVKFSASALLAGLIALPLVLLARSVSVVLPAAALSRAHEFEP 355
Query: 353 YL--FIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWG---EIIMATVVITVLTSVIV 407
Y + G RG + ALA TV G E+ + + V+ S+IV
Sbjct: 356 YTRRLMIWGGLRGAISVALA--------------FTVPAGPQRELFLVMTYVVVVFSIIV 401
Query: 408 ETLWI 412
+ L +
Sbjct: 402 QGLTV 406
>pir||T43930 hypothetical protein [imported] - Plectonema boryanum (fragment)
>gi|3123725|dbj|BAA25992.1| (AB005556) hypothetical
protein [Plectonema boryanum]
Length = 295
Score = 78.4 bits (190), Expect = 2e-13
Identities = 78/322 (24%), Positives = 150/322 (46%), Gaps = 38/322 (11%)
Query: 2 IELSLAEALFLIL--FTGVISMLISRRTGISYVPIFILTGLVIGP-LLKLIPRDLAHEIF 58
++ +LA L +++ G+ + +++ I + +L G+++G +L + D
Sbjct: 1 MDATLATTLQIVITVMAGIGAQVVAEWVQIPAIVFLLLFGVILGSSVLNWLHPDQLGTGL 60
Query: 59 DFVRVFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLL 118
+ + + +ILF G NL R L + ++ L TIG ++T L G + + +
Sbjct: 61 EVLIALLVAVILFEGGFNLQLRELGRVSGSLRNLVTIGTLITILGGGLAAHWLSEFPWSI 120
Query: 119 GFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYG 178
FL+ A++ T P + L R +V + + T++ E + DP+G +L ++ +++++ G
Sbjct: 121 AFLYAALVVVTGPVVINSLLRHVKVDRQVATILEGEGVLIDPIGAILAVVVLNVVLNGQS 180
Query: 179 G--GIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFL-GILGYKFIKRTGIFDFPEIEAF 235
I L +LGI GG+ ++G +L G+L R F +++
Sbjct: 181 NPFNIAGDLILRLGI-GGGI----------GAIGAWLMGVL-----LRRATFLSEDLKTL 224
Query: 236 SLSLAFLGFF-IGERLDASGYLVAT-VTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHF 293
+ G F + + + + L+AT V GIVL + L P E R+LKR F
Sbjct: 225 VVLAGLWGLFGLAQTIRSEAGLMATVVAGIVLRAFAL--PEE--RLLKR----------F 270
Query: 294 NDTLAALATIFIFVLLGAEMNL 315
L LA +F+LL A++++
Sbjct: 271 KGQLTTLAVSVLFILLSADLSI 292
>gi|6981562 solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter
3, Na+/H+ (amiloride insensitive) [Rattus norvegicus]
>gi|127813|sp|P26433|NAH3_RAT SODIUM/HYDROGEN EXCHANGER
3 (NA(+)/H(+) EXCHANGER 3) (NHE-3)
>gi|112015|pir||B40204 Na+/H+-exchanging protein 3 - rat
>gi|205707|gb|AAA41702.1| (M85300) sodium-hydrogen
exchange protein-isoform 3 [Rattus norvegicus]
Length = 831
Score = 77.3 bits (187), Expect = 3e-13
Identities = 106/431 (24%), Positives = 175/431 (40%), Gaps = 57/431 (13%)
Query: 34 IFILTGLVIGPLLKLIPRDLAHEIFDFVRVFGLVI-ILFTEGHNLSWRLLKKNMPTIVTL 92
+ I+ GLV+G ++ + + + F L+ I+ G+ + RL N+ TI+
Sbjct: 84 LLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLY 143
Query: 93 DTIGLILTALIAGFIFKVVFNSSF-------LLGFL-FGAIIGATDPATLIPLFRQYRVK 144
IG I A G VF S LL FL FG++I A DP ++ +F + V
Sbjct: 144 AVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVN 203
Query: 145 QDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLYNVS 204
+ + ++ ES+ ND + +VL + S + GG + + GI V +F+ ++
Sbjct: 204 EVLFIIVFGESLLNDAVTVVLYNVFESFVT--LGGDAVTGVDCVKGI----VSFFVVSLG 257
Query: 205 VSISLGIFLGILGY--KFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVTG 262
++ IF +L +F K I + F +++L + E L S L T G
Sbjct: 258 GTLVGVIFAFLLSLVTRFTKHVRIIE----PGFVFVISYLSYLTSEMLSLSAILAITFCG 313
Query: 263 IVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNL 322
I Y E R + LA+ A IF+ LG VIW+
Sbjct: 314 ICCQKYVKANISEQSATTVRYTMKM---------LASGAETIIFMFLGISAVDPVIWTWN 364
Query: 323 GKGLLVALGVMILARPLATLPLLKWWNFREYLFIALE----------GPRGVVPSALASL 372
+L+ L + + R + +L+ W Y + LE G RG V AL L
Sbjct: 365 TAFVLLTLVFISVYRAIGV--VLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVL 422
Query: 373 PLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIKERIEEK 432
+K K+ + ++T +I V +VI + L I L + +K + E+
Sbjct: 423 LDEKKVKEKN---------LFVSTTLIVVFFTVIFQGLTIKPLV------QWLKVKRSEQ 467
Query: 433 EEEKERRKVRG 443
E K K+ G
Sbjct: 468 REPKLNEKLHG 478
>pir||A75494 probable Na+/H+ antiporter - Deinococcus radiodurans (strain R1)
>gi|6458350|gb|AAF10227.1|AE001922_7 (AE001922) Na+/H+
antiporter, putative [Deinococcus radiodurans]
Length = 446
Score = 77.3 bits (187), Expect = 3e-13
Identities = 111/436 (25%), Positives = 184/436 (41%), Gaps = 47/436 (10%)
Query: 12 LILFTGVISMLISR------RTGISYVPIFILTGL-VIGPL----LKLIPRDLAHEIFDF 60
L T ++S L +R G+ +F+ G+ V+G L + +PR +A FD
Sbjct: 10 LFTLTALLSYLNARFLRLPPTIGVLLGGLFLAAGVAVLGRLGVQGAQDLPRHIAALPFDQ 69
Query: 61 VRVFGLV-IILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAG---FIFKVVFNS-- 114
V + GL+ +LF R L + ++ L + +LT L+ G ++ +F S
Sbjct: 70 VVIAGLLSFLLFASAIQTDVRALLRERGVVLALAVVTTLLTMLLLGAGLYVVMQLFGSPL 129
Query: 115 SFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLV 174
++ LFGAI+ TDP + PL + RV + + +I ES+FND +G+ + S +
Sbjct: 130 TWTQALLFGAIVAPTDPVAVTPLLERARVPERLRALIAGESLFNDGVGVAAFTVLSSAAL 189
Query: 175 PGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEA 234
G + +LG G L + ++LG LG L + D +
Sbjct: 190 QG--------SAVRLGELGG---LLLREMLGGMALGAALGWLTARLTTSARSQDTAVL-- 236
Query: 235 FSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENI-----RILKRLQRAIEK 289
SL+L G+ +GE L S + G+ L L R + +RA +
Sbjct: 237 LSLALVTGGYALGEALHVSAPVTVAAAGVTLMLLGQLARRRRAASGFPTLSAEARRASLQ 296
Query: 290 EVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVM-----ILARPLAT-LP 343
F + + +FVLL LEV+ GLL+A G++ I+AR +A +P
Sbjct: 297 IRSFWEVTDQVLNAVLFVLLA----LEVLVLRPRPGLLLA-GIVVAMLAIVARGIAVGVP 351
Query: 344 L-LKWWNFREYLFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVL 402
L L W R + P A L ++AL L + ++ + V+
Sbjct: 352 LTLYQWRARRRPELQPFTPYTRRLMTWAGLRGTVALALAFSLPPGELRDTLLFLTYVVVI 411
Query: 403 TSVIVETLWIPILKDK 418
S++V+ L +PIL K
Sbjct: 412 FSLLVQGLTVPILGRK 427
>pir||C83159 Na+/H+ antiporter NhaP PA3887 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|3327262|dbj|BAA31695.1| (AB010827)
NhaP [Pseudomonas aeruginosa]
>gi|9950068|gb|AAG07274.1|AE004806_1 (AE004806) Na+/H+
antiporter NhaP [Pseudomonas aeruginosa]
Length = 424
Score = 76.5 bits (185), Expect = 6e-13
Identities = 97/405 (23%), Positives = 174/405 (42%), Gaps = 57/405 (14%)
Query: 44 PLLKLIPRDLAHEIFDFVRV---FGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILT 100
P+L++ +++ I DF V + L +LF ++ L+ I L T G+++
Sbjct: 51 PILEVEMQEIIRRI-DFSEVLMTWFLPALLFAGALHVDLSDLRSYKWPIGLLATAGVLIA 109
Query: 101 ALIAGFIFKVVF-----NSSFLLGFLFGAIIGATDPATLIPLFRQYRVKQDIETVIVTES 155
+ G + F F+ LFGA+I TDP ++ + + + + T IV ES
Sbjct: 110 TFVIGGLAYYTFPLFGWQVDFIYCLLFGALISPTDPIAVLGILKSAGAPKPLATTIVGES 169
Query: 156 IFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGI 215
+FND +V+ I + +L L E + A +++ V +I +F +
Sbjct: 170 LFNDGTAVVVFAIILGIL----------QLGEAPTVSATAILF----VQEAIGGVVFGAV 215
Query: 216 LGY-KFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPR 274
LGY F+ GI + +L+L G + RL S + V G+++GN+
Sbjct: 216 LGYGVFVMMRGIDQYQVEVMLTLALVIGGAALAARLHVSAPIAMVVAGLIIGNH-----G 270
Query: 275 ENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMI 334
+ + +R ++K F + + + +F L+G E+ L + +S L ALG +
Sbjct: 271 RHYAMSDETRRYVDK---FWELIDEILNALLFALIGLEL-LLLPFSWLHVAAAFALGGAV 326
Query: 335 LARPLATL--PLLKWWNFR---------EYLFIALEGPRGVVPSALA-SLPLSLALKYKS 382
L L T+ +L FR + G RG V ALA SLPL
Sbjct: 327 LVSRLLTVGPAILVLRRFRGANRQVPAGTIRILVWGGLRGGVSVALALSLPLGPE----- 381
Query: 383 PLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIKE 427
++I++ I VL S++++ L I L ++ G+ +++
Sbjct: 382 -------RDLILSLTYIVVLVSILLQGLSIGPLVRRIYAGQPLEK 419
>sp|P26432|NAH3_RABIT SODIUM/HYDROGEN EXCHANGER 3 (NA(+)/H(+) EXCHANGER 3) (NHE-3)
>gi|109330|pir||A40205 Na+/H+-exchanging protein 3 -
rabbit >gi|165549|gb|AAA31420.1| (M87007) Na/H exchanger
3 [Oryctolagus cuniculus]
Length = 832
Score = 74.9 bits (181), Expect = 2e-12
Identities = 104/432 (24%), Positives = 174/432 (40%), Gaps = 59/432 (13%)
Query: 34 IFILTGLVIGPLLKLIPRDLAHEIFDFVRVFGLVI-ILFTEGHNLSWRLLKKNMPTIVTL 92
+ I+ GLV+G ++ + + V F L+ I+ G+ + RL N+ +I+
Sbjct: 86 LLIVLGLVLGGIVLAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFSNLGSILLY 145
Query: 93 DTIGLILTALIAGFIFKVVFNSSF-------LLGFL-FGAIIGATDPATLIPLFRQYRVK 144
+G + A G VF S LL FL FG++I A DP ++ +F + V
Sbjct: 146 AVVGTVWNAATTGLSLYGVFLSGIMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVN 205
Query: 145 QDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLYNVS 204
+ + ++ ES+ ND + +VL + S + GG + + GI V +F+ ++
Sbjct: 206 EVLFIIVFGESLLNDAVTVVLYNVFQSFVT--LGGDKVTGVDCVKGI----VSFFVVSLG 259
Query: 205 VSISLGIFLGILGY--KFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVTG 262
++ +F +L +F K + + F +++L + E L S L T G
Sbjct: 260 GTLVGVVFAFLLSLVTRFTKHVRVIE----PGFVFIISYLSYLTSEMLSLSSILAITFCG 315
Query: 263 IVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWS-N 321
I Y E R + LA+ A IF+ LG +IW+ N
Sbjct: 316 ICCQKYVKANISEQSATTVRYTMKM---------LASGAETIIFMFLGISAVDPLIWTWN 366
Query: 322 LGKGLLVALGVMILARPLATLPLLKWWNFREYLFIALE----------GPRGVVPSALAS 371
LL L V + A +L+ W Y + LE G RG V AL +
Sbjct: 367 TAFVLLTLLFVSVFR---AIGVVLQTWLLNRYRMVQLELIDQVVMSYGGLRGAVAFALVA 423
Query: 372 LPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIKERIEE 431
L +K K+ + ++T +I V +VI + L I L + +K + E
Sbjct: 424 LLDGNKVKEKN---------LFVSTTIIVVFFTVIFQGLTIKPLV------QWLKVKRSE 468
Query: 432 KEEEKERRKVRG 443
E K K+ G
Sbjct: 469 HREPKLNEKLHG 480
>sp|P50482|NAH2_RABIT SODIUM/HYDROGEN EXCHANGER 2 (NA(+)/H(+) EXCHANGER 2) (NHE-2)
>gi|423344|pir||A46747 Na+/H+-exchanging protein NHE-2 -
rabbit
Length = 809
Score = 74.5 bits (180), Expect = 2e-12
Identities = 92/424 (21%), Positives = 178/424 (41%), Gaps = 58/424 (13%)
Query: 34 IFILTGLVIGPLL----KLIPRDLAHEIFDFVRVFGLVIILFTEGHNLSWRLLKKNMPTI 89
+ I+ GL++G ++ + P + ++F ++ L I+ G+ + R +N+ TI
Sbjct: 113 LLIMVGLLLGGIIFGVDEKSPPAMKTDVFF---LYLLPPIVLDAGYFMPTRPFFENLGTI 169
Query: 90 VTLDTIGLILTALIAGF-IFKVVFNSSF-------LLGFLFGAIIGATDPATLIPLFRQY 141
+G + ++ G +F + +F L LFG++I A DP ++ +F
Sbjct: 170 FWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENI 229
Query: 142 RVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLY 201
V + + ++ ES+ ND + +VL + S T+ E + ++AG +F+
Sbjct: 230 HVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQ-------MKTI-ETIDVFAGIANFFVV 281
Query: 202 NVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVT 261
+ + +GIFLG + + T E F ++L + E SG + T
Sbjct: 282 GIG-GVLIGIFLGFIAAFTTRFTHNIRVIE-PLFVFLYSYLSYITAEMFHLSGIMAITAC 339
Query: 262 GIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGA-------EMN 314
+ + Y EN+ Q++ +F L++++ IF+ +G E N
Sbjct: 340 AMTMNKY----VEENVS-----QKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWN 390
Query: 315 LEVIWSNLGKGLL-VALGVMILARPL---ATLPLLKWWNFREYLFIALEGPRGVVPSALA 370
+ L L+ ALGV +L R + T+PL F++ IA G RG +
Sbjct: 391 WAFVCFTLAFCLIWRALGVFVLTRVINWFRTIPL----TFKDQFIIAYGGLRGAI----- 441
Query: 371 SLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIKERIE 430
AL + P ++ + ++ + +V + + I L + LDV + K++
Sbjct: 442 ----CFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQA 497
Query: 431 EKEE 434
EE
Sbjct: 498 VSEE 501
>pir||F69201 conserved hypothetical protein MTH760 - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621849|gb|AAB85263.1| (AE000854) Na+/H+-exchanging
protein:Na+/H+ antiporter [Methanobacterium
thermoautotrophicum]
Length = 399
Score = 74.5 bits (180), Expect = 2e-12
Identities = 94/409 (22%), Positives = 187/409 (44%), Gaps = 49/409 (11%)
Query: 6 LAEALFLILFTGVISMLISRRTGISYVPIFILTGLVIGPL-LKLIPRDLAHEIFDFVRVF 64
+A ++ +I+ G++ + R + + ++ G++IGP L LI + + +I +RV
Sbjct: 4 VAFSVAVIILLGLLFNRVFTRARLPGILGMLILGILIGPHGLNLISKSIM-DISPDLRVI 62
Query: 65 GLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSFLLGFLFGA 124
L+IIL G ++ L+K T V + I + L + + + G
Sbjct: 63 ALIIILLRAGFGINLESLRKVGMTAVKMSFIPDVFEGLAVMVASHYILGLPIIEAGILGF 122
Query: 125 IIGATDPATLIP-----LFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGG 179
+I A PA ++P + R+ + I T+I+T + +D + I L S+ + Y G
Sbjct: 123 VIAAVSPAVIVPQMLSFIERRMGTAKGIPTIILTGASVDDVVSITL----FSVFLGIYQG 178
Query: 180 GIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSL 239
+ L E +G+ + L ++ ++LG+ L L +F R E L
Sbjct: 179 QQVNLLVEAIGV----PLSILTGITGGLALGLALVYLFRRFEIRN-----TEKTLIILGA 229
Query: 240 AFLGFFIGERLDASGYL-VATVTGIVLGNYKLLK--PRENIRILKRLQRAIEKEVHFNDT 296
A L +G+ + S YL +A + G+++ +L+ P +++ ++ +
Sbjct: 230 AILLKNMGDLI--STYLPIAALVGVMVVGLVILERMPETGLKLSEKFNK----------- 276
Query: 297 LAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLATLPLLKW--WNFREYL 354
+ A I +FVL+GA++++ +I+ ++G L + ++ R + L LK N +E +
Sbjct: 277 VWIFAEILLFVLVGAQVDVRLIF-HVGLLGLAVITAGLMVRSIGVLLSLKGTDLNLKEKV 335
Query: 355 F-IALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVL 402
F I+ P+ V +A+ ++PL+ V GE I+A V+ +L
Sbjct: 336 FCISAYIPKATVQAAIGAIPLAAG---------VAAGETILAMAVLAIL 375
>pir||T34941 probable Na+/H+ antiporter - Streptomyces coelicolor
>gi|5689943|emb|CAB51980.1| (AL109663) putative Na+/H+
antiporter [Streptomyces coelicolor A3(2)]
Length = 528
Score = 74.5 bits (180), Expect = 2e-12
Identities = 107/454 (23%), Positives = 187/454 (40%), Gaps = 64/454 (14%)
Query: 10 LFLILFTGVISMLISRRTGISYVPIFILTGLVIGPLLKLIPR-DLAHEIFDFVRVFGLVI 68
LF++L ++S+ I R G+ + L G+V+ LL +P D+ E+ + GL+
Sbjct: 7 LFMLLLGALLSVPIGARLGLPAPVLMTLLGIVLA-LLDFVPNVDIPPELI----LPGLLP 61
Query: 69 -ILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTAL-IAGFIFKVVFNSSFLLGFLFGAII 126
+L+ SWR N I L + +T + +A +V F GA++
Sbjct: 62 PLLYAAVRRTSWRQFAANKRPIFLLAVALVFVTMVCVASVAHAIVPGLPIAAAFALGALV 121
Query: 127 GATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLS 186
DP + Q + + + +++ E +FND IVL +AI+ V GG FS
Sbjct: 122 APPDPVAATAVAGQLGLPRRLVSILEGEGLFNDVTAIVLYHVAIAAAV----GGSFSPWR 177
Query: 187 EKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIE-AFSLSLAFLGFF 245
+ V V++++G+ +LG+ K + P ++ +L + F+ +
Sbjct: 178 AGFDLVLSAV--------VAVAIGL---VLGWGSNKLMSVLGDPTLQIGLTLLVPFVSYV 226
Query: 246 IGERLDASGYLVATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFI 305
+ L SG L T + L Y + ++ RL D + L T
Sbjct: 227 AADELHGSGVLAVLTTAMFLAEY----ASDADDVMTRLGGHT-----VWDVVDTLVTGVA 277
Query: 306 FVLLGAEMNLEV-----IWSNLGKGLLVALGVMILARPLATLPLLKW------------- 347
F L+G E++ V W+ L L V++L R L LP W
Sbjct: 278 FGLIGLELHNAVRTASGRWTELLGWAAAILVVVVLVRLLWLLP-ATWLTQRLHARRDQDE 336
Query: 348 ---WNFREYLFIALEGPRGVVPSALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTS 404
++RE + + G RGV ALA L++ L+ H EI+ + ++ +
Sbjct: 337 DIPTSWRETVVMWWAGMRGVASVALA---LAIPLETDDGAAFPHREEIVFIAFGV-IMGT 392
Query: 405 VIVETLWIPILKDKLDVGETIKERIEEKEEEKER 438
++++ L +P L +L V E+E+E ER
Sbjct: 393 LLLQGLTLPWLVGRLGV-----RADTEREQEFER 421
>gi|6806921 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3
[Homo sapiens] >gi|1346659|sp|P48764|NAH3_HUMAN
SODIUM/HYDROGEN EXCHANGER 3 (NA(+)/H(+) EXCHANGER 3)
(NHE-3) >gi|971209|gb|AAB48990.1| (U28043) plasma
membrane Na+/H+ exchanger isoform 3 [Homo sapiens]
>gi|1581613|prf||2117155A Na/H exchanger NHE3 [Homo
sapiens]
Length = 834
Score = 73.7 bits (178), Expect = 4e-12
Identities = 105/428 (24%), Positives = 166/428 (38%), Gaps = 65/428 (15%)
Query: 34 IFILTGLVIGPLLKLIPRDLAHEIFDFVRVFGLVI-ILFTEGHNLSWRLLKKNMPTIVTL 92
+ I+ GLV+G ++ + + V F L+ I+ G+ + RL N+ TI+
Sbjct: 87 LLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLY 146
Query: 93 DTIGLILTALIAGFIFKVVFNSSF-------LLGFL-FGAIIGATDPATLIPLFRQYRVK 144
+G + A G VF S LL FL FG+++ A DP ++ +F + V
Sbjct: 147 AVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVN 206
Query: 145 QDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGG--------GIFSTLSEKLGIYAGGV 196
+ + ++ ES+ ND + +VL + S + G GI S LG GV
Sbjct: 207 EVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGV 266
Query: 197 IYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYL 256
++ FL L +F K I + F +++L + E L S L
Sbjct: 267 VF------------AFLLSLVTRFTKHVRIIE----PGFVFIISYLSYLTSEMLSLSAIL 310
Query: 257 VATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLE 316
T GI Y E R + LA+ A IF+ LG
Sbjct: 311 AITFCGICCQKYVKANISEQSATTVRYTMKM---------LASSAETIIFMFLGISAVNP 361
Query: 317 VIWSNLGKGLLVALGVMILARPLATLPLLKWWNFREYLFIALE----------GPRGVVP 366
IW+ +L+ L + + R + +L+ W Y + LE G RG V
Sbjct: 362 FIWTWNTAFVLLTLVFISVYRAIGV--VLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVA 419
Query: 367 SALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDV--GET 424
AL L +K K+ + ++T +I V +VI + L I L L V E
Sbjct: 420 FALVVLLDGDKVKEKN---------LFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEH 470
Query: 425 IKERIEEK 432
+ R+ EK
Sbjct: 471 REPRLNEK 478
>sp|Q28362|NAH3_DIDMA SODIUM/HYDROGEN EXCHANGER 3 (NA(+)/H(+) EXCHANGER 3) (NHE-3)
>gi|836676|gb|AAA98816.1| (L42522) Na+/H+ antiporter
[Didelphis virginiana] >gi|1581609|prf||2117153A Na/H
exchanger 3 [Didelphis virginiana]
Length = 839
Score = 72.6 bits (175), Expect = 9e-12
Identities = 106/430 (24%), Positives = 167/430 (38%), Gaps = 65/430 (15%)
Query: 34 IFILTGLVIGPLLKLIPRDLAHEIFDFVRVFGLVI-ILFTEGHNLSWRLLKKNMPTIVTL 92
+ I+ GL++G ++ + + V F L+ I+ G+ + RL N+ TI+
Sbjct: 92 LLIVLGLILGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLY 151
Query: 93 DTIGLILTALIAGFIFKVVFNSSF-------LLGFL-FGAIIGATDPATLIPLFRQYRVK 144
IG + A G V+ S LL FL FG++I A DP ++ +F + V
Sbjct: 152 AVIGTVWNAATTGLSLYGVYLSGIMGDLSIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVN 211
Query: 145 QDIETVIVTESIFNDPLGIVLTLIAISMLVPGYG--------GGIFSTLSEKLGIYAGGV 196
+ ++ ES+ ND + +VL + S + G GI S LG G+
Sbjct: 212 DVLFIIVFGESLLNDAVTVVLYNVFDSFVSLGADKVTGVDCVKGIVSFFVVSLGGTLIGI 271
Query: 197 IYFLYNVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYL 256
I+ FL L +F K I + F +++L + E L S L
Sbjct: 272 IF------------AFLLSLVTRFTKHVRIIE----PGFVFIISYLSYLTSEMLSLSAIL 315
Query: 257 VATVTGIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLE 316
T GI Y E R + LA+ A IF+ LG
Sbjct: 316 AITFCGICCQKYVKANISEQSATTVRYTMKM---------LASGAETIIFMFLGISAVDP 366
Query: 317 VIWSNLGKGLLVALGVMILARPLATLPLLKWWNFREYLFIALE----------GPRGVVP 366
IW+ +L+ L + + R + +L+ W +Y + LE G RG V
Sbjct: 367 AIWTWNTAFILLTLVFISVYRAIGV--VLQTWLLNKYRMVQLEIIDQVVMSYGGLRGAVA 424
Query: 367 SALASLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIK 426
AL L +K K+ + ++T +I V +VI + L I L L V ++
Sbjct: 425 YALVVLLDEKKVKEKN---------LFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKKS-- 473
Query: 427 ERIEEKEEEK 436
E E K EK
Sbjct: 474 EHREPKLNEK 483
>gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger), isoform 5
[Homo sapiens] >gi|4071359|gb|AAC98696.1| (AF111173)
sodium/hydrogen exchanger isoform 5 [Homo sapiens]
Length = 896
Score = 72.6 bits (175), Expect = 9e-12
Identities = 108/448 (24%), Positives = 183/448 (40%), Gaps = 70/448 (15%)
Query: 2 IELSLAEALFLILFTGVISMLISRRTGISYVP---IFILTGLVIGPLLKLIPRDLAHEIF 58
+E AL++++ + + R S VP + IL GLV+G ++ + + +++
Sbjct: 44 VEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLE 103
Query: 59 DFVR-VFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSF- 116
+F L I+ G+ + RL N+ I+T +G + A G + +
Sbjct: 104 PGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLV 163
Query: 117 -------LLGFL-FGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLI 168
LL FL FG++I A DP ++ +F + V + + ++ ES+ ND + +VL +
Sbjct: 164 APRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKV 223
Query: 169 AISMLVPG--------YGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKF 220
S + G Y G+ S LG A G+++ FL L +F
Sbjct: 224 CNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVF------------AFLLALTTRF 271
Query: 221 IKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRIL 280
KR I + LA+ + E S L T+ G LG K ++ +
Sbjct: 272 TKRVRIIE----PLLVFLLAYAAYLTAEMASLSAILAVTMCG--LGCKKYVEAN-----I 320
Query: 281 KRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMIL-ARPL 339
R K + TLA+ A IF+LLG W+ GL++ + IL R L
Sbjct: 321 SHKSRTTVK--YTMKTLASCAETVIFMLLGISAVDSSKWA-WDSGLVLGTLIFILFFRAL 377
Query: 340 ATLPLLKWWNFREYLFIALE----------GPRGVVPSALASLPLSLALKYKSPLLTVHW 389
+L+ W ++ + L+ G RG V AL L + K
Sbjct: 378 GV--VLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAK-------- 427
Query: 390 GEIIMATVVITVLTSVIVETLWI-PILK 416
+ +AT ++ V +VIV+ L I P++K
Sbjct: 428 -DYFVATTIVVVFFTVIVQGLTIKPLVK 454
>gb|AAD41635.1|AF073299_1 (AF073299) Na+/H+ exchanger isoform 2 [Homo sapiens]
>gi|6624113|gb|AAF19248.1|AC007239_1 (AC007239) Na+/H+
exchanger isoform 2 [Homo sapiens]
Length = 812
Score = 72.6 bits (175), Expect = 9e-12
Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 58/424 (13%)
Query: 34 IFILTGLVIGPLL----KLIPRDLAHEIFDFVRVFGLVIILFTEGHNLSWRLLKKNMPTI 89
+ I+ GL++G ++ + P + ++F ++ L I+ G+ + R +N+ TI
Sbjct: 113 LLIMVGLLLGGIIFGVDEKSPPAMKTDVFF---LYLLPPIVLDAGYFMPTRPFFENIGTI 169
Query: 90 VTLDTIGLILTALIAGF-IFKVVFNSSF-------LLGFLFGAIIGATDPATLIPLFRQY 141
+G + ++ G +F + +F L LFG++I A DP ++ +F
Sbjct: 170 FWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENI 229
Query: 142 RVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLY 201
V + + ++ ES+ ND + +VL + S T+ E + ++AG +F+
Sbjct: 230 HVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQ-------MKTI-ETIDVFAGIANFFVV 281
Query: 202 NVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVT 261
+ + +GIFLG + + T E F ++L + E SG + T
Sbjct: 282 GIG-GVLIGIFLGFIAAFTTRFTHNIRVIE-PLFVFLYSYLSYITAEMFHLSGIMAITAC 339
Query: 262 GIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGA-------EMN 314
+ + Y EN+ Q++ +F L++++ IF+ +G E N
Sbjct: 340 AMTMNKY----VEENVS-----QKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWN 390
Query: 315 LEVIWSNLGKGLL-VALGVMILARPL---ATLPLLKWWNFREYLFIALEGPRGVVPSALA 370
+ L L+ ALGV +L + + T+PL F++ IA G RG +
Sbjct: 391 WAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPL----TFKDQFIIAYGGLRGAI----- 441
Query: 371 SLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIKERIE 430
AL + P ++ + ++ + +V + + I L + LDV + K++
Sbjct: 442 ----CFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQA 497
Query: 431 EKEE 434
EE
Sbjct: 498 VSEE 501
>gi|11430753 solute carrier family 9 (sodium/hydrogen exchanger), isoform 5
[Homo sapiens]
Length = 918
Score = 72.6 bits (175), Expect = 9e-12
Identities = 108/448 (24%), Positives = 183/448 (40%), Gaps = 70/448 (15%)
Query: 2 IELSLAEALFLILFTGVISMLISRRTGISYVP---IFILTGLVIGPLLKLIPRDLAHEIF 58
+E AL++++ + + R S VP + IL GLV+G ++ + + +++
Sbjct: 66 VEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLE 125
Query: 59 DFVR-VFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSF- 116
+F L I+ G+ + RL N+ I+T +G + A G + +
Sbjct: 126 PGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLV 185
Query: 117 -------LLGFL-FGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLI 168
LL FL FG++I A DP ++ +F + V + + ++ ES+ ND + +VL +
Sbjct: 186 APRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKV 245
Query: 169 AISMLVPG--------YGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKF 220
S + G Y G+ S LG A G+++ FL L +F
Sbjct: 246 CNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVF------------AFLLALTTRF 293
Query: 221 IKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRIL 280
KR I + LA+ + E S L T+ G LG K ++ +
Sbjct: 294 TKRVRIIE----PLLVFLLAYAAYLTAEMASLSAILAVTMCG--LGCKKYVEAN-----I 342
Query: 281 KRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMIL-ARPL 339
R K + TLA+ A IF+LLG W+ GL++ + IL R L
Sbjct: 343 SHKSRTTVK--YTMKTLASCAETVIFMLLGISAVDSSKWA-WDSGLVLGTLIFILFFRAL 399
Query: 340 ATLPLLKWWNFREYLFIALE----------GPRGVVPSALASLPLSLALKYKSPLLTVHW 389
+L+ W ++ + L+ G RG V AL L + K
Sbjct: 400 GV--VLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAK-------- 449
Query: 390 GEIIMATVVITVLTSVIVETLWI-PILK 416
+ +AT ++ V +VIV+ L I P++K
Sbjct: 450 -DYFVATTIVVVFFTVIVQGLTIKPLVK 476
>sp|P48763|NAH2_RAT SODIUM/HYDROGEN EXCHANGER 2 (NA(+)/H(+) EXCHANGER 2) (NHE-2) (H7)
>gi|539977|pir||A46748 Na+/H+-exchanging protein NHE-2 -
rat >gi|205319|gb|AAA72350.1| (L11236) [Rattus rattus
mRNA sequence.], gene product
Length = 813
Score = 69.5 bits (167), Expect = 8e-11
Identities = 89/424 (20%), Positives = 177/424 (40%), Gaps = 58/424 (13%)
Query: 34 IFILTGLVIGPLL----KLIPRDLAHEIFDFVRVFGLVIILFTEGHNLSWRLLKKNMPTI 89
+ I+ GL++G ++ + P + ++F ++ L I+ G+ + R +N+ TI
Sbjct: 114 LLIMVGLLLGGIIFGVDEKSPPAMKTDVFF---LYLLPPIVLDAGYFMPTRPFFENLGTI 170
Query: 90 VTLDTIGLILTALIAGF-IFKVVFNSSF-------LLGFLFGAIIGATDPATLIPLFRQY 141
+G + ++ G +F + +F L LFG++I A DP ++ +F
Sbjct: 171 FWYAVVGTLWNSIGIGLSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENI 230
Query: 142 RVKQDIETVIVTESIFNDPLGIVLTLIAISMLVPGYGGGIFSTLSEKLGIYAGGVIYFLY 201
V + + ++ ES+ ND + +VL + S T+ + + ++AG +F+
Sbjct: 231 HVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQ-------MKTI-QTVDVFAGIANFFVV 282
Query: 202 NVSVSISLGIFLGILGYKFIKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVT 261
+ + +GI LG + + T E F ++L + E SG + T
Sbjct: 283 GIG-GVLIGILLGFIAAFTTRFTHNIRVIE-PLFVFLYSYLSYITAEMFHLSGIMAITAC 340
Query: 262 GIVLGNYKLLKPRENIRILKRLQRAIEKEVHFNDTLAALATIFIFVLLGA-------EMN 314
+ + Y EN+ Q++ +F L++++ IF+ +G E N
Sbjct: 341 AMTMNKY----VEENVS-----QKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWN 391
Query: 315 LEVIWSNLGKGLL-VALGVMILARPL---ATLPLLKWWNFREYLFIALEGPRGVVPSALA 370
+ L L+ ALGV +L + + T+PL F++ IA G RG +
Sbjct: 392 WAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPL----TFKDQFIIAYGGLRGAI----- 442
Query: 371 SLPLSLALKYKSPLLTVHWGEIIMATVVITVLTSVIVETLWIPILKDKLDVGETIKERIE 430
AL + P ++ + ++ + +V + + I L + LDV + K++
Sbjct: 443 ----CFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQA 498
Query: 431 EKEE 434
EE
Sbjct: 499 VSEE 502
>sp|Q9Z0X2|NAH5_RAT SODIUM/HYDROGEN EXCHANGER 5 (NA(+)/H(+) EXCHANGER 5) (NHE-5)
>gi|4323549|gb|AAD16413.1| (AF100172) sodium/hydrogen
exchanger 5 [Rattus norvegicus]
Length = 898
Score = 69.1 bits (166), Expect = 1e-10
Identities = 103/447 (23%), Positives = 178/447 (39%), Gaps = 68/447 (15%)
Query: 2 IELSLAEALFLILFTGVISMLISRRTGISYVP---IFILTGLVIGPLLKLIPRDLAHEIF 58
+E AL++++ + + R S VP + IL GL +G ++ + + +++
Sbjct: 46 VEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLALGGIVLAVAKKAEYQLE 105
Query: 59 DFVR-VFGLVIILFTEGHNLSWRLLKKNMPTIVTLDTIGLILTALIAGFIFKVVFNSSF- 116
+F L I+ G+ + RL N+ I+T +G + A G + +
Sbjct: 106 PGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLV 165
Query: 117 -------LLGFL-FGAIIGATDPATLIPLFRQYRVKQDIETVIVTESIFNDPLGIVLTLI 168
LL FL FG++I A DP ++ +F + V + + ++ ES+ ND + VL +
Sbjct: 166 APRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTAVLYKV 225
Query: 169 AISMLVPG--------YGGGIFSTLSEKLGIYAGGVIYFLYNVSVSISLGIFLGILGYKF 220
S + G Y G+ S LG A G+++ FL L +F
Sbjct: 226 CNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVF------------AFLLALTTRF 273
Query: 221 IKRTGIFDFPEIEAFSLSLAFLGFFIGERLDASGYLVATVTGIVLGNYKLLKPRENIRIL 280
KR I + LA+ + E S L T+ G+ Y I
Sbjct: 274 TKRVRIIE----PLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKY------VEANIS 323
Query: 281 KRLQRAIEKEVHFNDTLAALATIFIFVLLGAEMNLEVIWSNLGKGLLVALGVMILARPLA 340
+ + A++ + TLA+ A IF+LLG W+ +L L ++ R L
Sbjct: 324 HKSRTAVK---YTMKTLASSAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALG 380
Query: 341 TLPLLKWWNFREYLFIALE----------GPRGVVPSALASLPLSLALKYKSPLLTVHWG 390
+L+ W ++ L+ G RG V AL L + K
Sbjct: 381 V--VLQTWVLNQFRLAPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAK--------- 429
Query: 391 EIIMATVVITVLTSVIVETLWI-PILK 416
+ +AT ++ V +VIV+ L I P++K
Sbjct: 430 DYFVATTIVVVFFTVIVQGLTIKPLVK 456
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.328 0.147 0.426
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 153772813
Number of Sequences: 2977
Number of extensions: 6592115
Number of successful extensions: 30400
Number of sequences better than 1.0e-10: 47
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 30306
Number of HSP's gapped (non-prelim): 56
length of query: 443
length of database: 189,106,746
effective HSP length: 53
effective length of query: 390
effective length of database: 157,386,935
effective search space: 61380904650
effective search space used: 61380904650
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.7 bits)
S2: 166 (69.1 bits)