BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1637 (pepQ-2) DE:cobalt-dependent proline dipeptidase
(pepQ-2)
(351 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||E75088 cobalt-dependent proline dipeptidase (pepq-2) PAB163... 695 0.0
pir||G71056 probable X-Pro dipeptidase - Pyrococcus horikoshii >... 610 e-173
pir||T46973 X-Pro dipeptidase (EC 3.4.13.9), cobalt dependent [v... 579 e-164
dbj|BAB06519.1| (AP001516) Xaa-Pro dipeptidase [Bacillus halodur... 279 3e-74
sp|P54518|YQHT_BACSU PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INTERGE... 278 8e-74
pir||G72425 hypothetical protein TM0042 - Thermotoga maritima (s... 265 4e-70
emb|CAA70068.1| (Y08842) aminopeptidase P [Lactococcus lactis] 256 4e-67
pir||D75419 proline dipeptidase - Deinococcus radiodurans (strai... 247 2e-64
sp|Q58216|Y806_METJA HYPOTHETICAL PEPTIDASE MJ0806 >gi|2129355|p... 242 6e-63
pir||G69869 Xaa-Pro dipeptidase homolog ykvY - Bacillus subtilis... 241 1e-62
pir||A71089 probable dipeptidase - Pyrococcus horikoshii >gi|325... 241 1e-62
emb|CAC12166.1| (AL445066) proline dipeptidase related protein [... 238 5e-62
pir||D69231 probable X-Pro dipeptidase (EC 3.4.13.9) - Methanoba... 232 4e-60
pir||C75134 x-pro aminopeptidase (pepq-3) PAB1781 - Pyrococcus a... 230 2e-59
emb|CAB07978.1| (Z93944) prolidase [Lactobacillus delbrueckii] 229 5e-59
sp|P46545|PEPQ_LACDL XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PR... 229 5e-59
sp|Q9S6S1|PEPQ_LACDE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PR... 228 6e-59
pir||F65012 hypothetical protein b2385 - Escherichia coli (strai... 228 1e-58
dbj|BAB06898.1| (AP001518) prolidase (proline dipeptidase) [Baci... 227 1e-58
sp|O84913|PEPQ_LACHE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PR... 222 5e-57
dbj|BAA16255.1| (D90868) PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INT... 221 1e-56
gb|AAC46293.1| (AF014460) PepQ [Streptococcus mutans] 220 2e-56
gb|AAK40693.1| Prolidase (Xaa-Pro dipeptidase) (pepQ) [Sulfolobu... 217 2e-55
gb|AAD53120.1|AF176799_2 (AF176799) PepQ [Lactobacillus pentosus] 211 9e-54
pir||C70658 probable pepQ - Mycobacterium tuberculosis (strain H... 201 1e-50
pir||C70433 probable X-Pro dipeptidase (EC 3.4.13.9) - Aquifex a... 198 1e-49
gb|AAK40375.1| X-pro aminopeptidase [Sulfolobus solfataricus] 195 7e-49
pir||B72032 proline dipeptidase CP1058 [imported] - Chlamydophil... 195 7e-49
pir||A72750 probable Xaa-Pro dipeptidase APE0526 - Aeropyrum per... 194 1e-48
sp|P75313|AMPP_MYCPN PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMIN... 193 3e-48
pir||H71496 probable aminopeptidase P - Chlamydia trachomatis (s... 192 4e-48
emb|CAB07979.1| (Z93945) prolidase-related protein [Lactobacillu... 191 8e-48
pir||T35868 probable dipeptidase - Streptomyces coelicolor >gi|4... 189 4e-47
pir||F81657 proline dipeptidase TC0863 [imported] - Chlamydia mu... 185 8e-46
pir||F82878 XAA-PRO aminopeptidase UU532 [imported] - Ureaplasma... 183 2e-45
sp|P47566|AMPP_MYCGE PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMIN... 180 2e-44
sp|Q10698|YK89_MYCTU PROBABLE DIPEPTIDASE RV2089C >gi|7445465|pi... 175 9e-43
pir||A71938 probable proline peptidase - Helicobacter pylori (st... 172 6e-42
gb|AAG19202.1| (AE005016) probable peptidase; PepQ1 [Halobacteri... 172 6e-42
pir||E64649 probable X-Pro dipeptidase (EC 3.4.13.9) - Helicobac... 169 4e-41
emb|CAC10315.1| (AL442629) putative peptidase [Streptomyces coel... 169 5e-41
emb|CAB93372.1| (AL357523) putative peptidase [Streptomyces coel... 164 1e-39
gi|11499616 X-pro aminopeptidase (pepQ) [Archaeoglobus fulgidus]... 149 5e-35
pir||A83084 probable metallopeptidase PA4498 [imported] - Pseudo... 148 1e-34
gb|AAD18095.1| (AC006416) Similar to gi|1573829 HI0816 aminopept... 147 1e-34
sp|P44881|AMPP_HAEIN XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDAS... 146 3e-34
sp|P15034|AMPP_ECOLI XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDAS... 143 2e-33
pdb|1A16| Aminopeptidase P From E. Coli With The Inhibitor Pro... 143 2e-33
pdb|1AZ9| Aminopeptidase P From E. Coli 143 2e-33
pdb|1JAW| Aminopeptidase P From E. Coli Low Ph Form 143 2e-33
pir||H82833 proline dipeptidase XF0220 [imported] - Xylella fast... 142 6e-33
gb|AAG10442.1|AF279106_4 (AF279106) predicted Xaa-Pro aminopepti... 141 8e-33
gb|AAB96776.1| (AF041033) aminopeptidase [Shigella flexneri] 141 8e-33
pir||S76440 hypothetical protein - Synechocystis sp. (strain PCC... 140 2e-32
pir||B75217 x-pro dipeptidase PAB2178 - Pyrococcus abyssi (strai... 139 3e-32
gb|AAG19595.1| (AE005049) X-pro aminopeptidase homolog; PepQ2 [H... 139 4e-32
pir||D71204 hypothetical protein PH1902 - Pyrococcus horikoshii ... 138 1e-31
pir||H82992 aminopeptidase P PA5224 [imported] - Pseudomonas aer... 136 3e-31
pir||T39750 probable dipeptidase - fission yeast (Schizosaccharo... 131 9e-30
dbj|BAB05458.1| (AP001513) Xaa-Pro dipeptidase [Bacillus halodur... 128 1e-28
gi|6321118 Yfr006wp [Saccharomyces cerevisiae] >gi|1175977|sp|P4... 120 2e-26
gi|11559925 hypothetical protein LOC63929 [Homo sapiens] >gi|918... 114 1e-24
pir||F82609 aminopeptidase P XF2009 [imported] - Xylella fastidi... 112 5e-24
gb|AAF45368.1| (AE002611) CG9581 gene product [Drosophila melano... 111 9e-24
sp|P55667|Y4TM_RHISN HYPOTHETICAL HYDROLASE/PEPTIDASE Y4TM >gi|2... 108 1e-22
emb|CAA75230.1| (Y14996) prolidase [Suberites domuncula] 106 3e-22
gi|6320922 Yer078cp [Saccharomyces cerevisiae] >gi|731481|sp|P40... 105 7e-22
gb|AAF54806.1| (AE003695) CG5663 gene product [Drosophila melano... 104 1e-21
sp|P38487|CREA_BACSP CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|... 104 1e-21
pir||T44250 creatinase (EC 3.5.3.3) [validated] - Arthrobacter s... 104 2e-21
gi|11425821 Xaa-Pro dipeptidase [Homo sapiens] 103 3e-21
sp|Q05813|AMP1_STRLI XAA-PRO AMINOPEPTIDASE I (X-PRO AMINOPEPTID... 103 3e-21
sp|Q10439|YDE5_SCHPO PROBABLE 55.1 KDA PEPTIDASE C12B10.05 >gi|7... 102 6e-21
pir||S72196 X-Pro dipeptidase (EC 3.4.13.9) - mouse 102 8e-21
dbj|BAB11685.1| (D82983) prolidase [Mus musculus] 102 8e-21
pir||E81084 aminopeptidase, probable NMB1428 [imported] - Neisse... 101 1e-20
sp|O84859|AMPM_CHLTR METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 101 1e-20
pir||D81858 probable aminopeptidase NMA1640 [imported] - Neisser... 101 1e-20
gi|6679279 peptidase 4 [Mus musculus] >gi|1709633|sp|Q11136|PEPD... 100 2e-20
gi|4557835 Xaa-Pro dipeptidase; prolidase; Peptidase D (prolidas... 98 2e-19
pir||T47008 hypothetical protein [imported] - Yersinia pestis >g... 98 2e-19
sp|P27875|AGS_AGRRH AGROPINE SYNTHESIS CYCLASE >gi|77884|pir||JQ... 98 2e-19
emb|CAC11625.1| (AL445064) proline dipeptidase related protein [... 98 2e-19
emb|CAB62984.1| (AL035450) dJ1057D18.1 (novel protein similar to... 96 4e-19
pir||A32454 X-Pro dipeptidase (EC 3.4.13.9) - human 95 1e-18
emb|CAA75231.1| (Y14997) prolidase [Suberites domuncula] 95 1e-18
sp|Q60394|AMP2_STRLI XAA-PRO AMINOPEPTIDASE II (X-PRO AMINOPEPTI... 95 1e-18
pir||S69353 aminopeptidase P - pig >gi|994862|gb|AAB34314.1| ami... 95 1e-18
pir||G81724 methionine aminopeptidase TC0240 [imported] - Chlamy... 95 1e-18
gi|10955029 ags [Agrobacterium tumefaciens] >gi|8572686|gb|AAF77... 94 3e-18
pir||D81414 probable aminopeptidase Cj0653c [imported] - Campylo... 93 5e-18
pir||S72440 X-Pro aminopeptidase (EC 3.4.11.9) precursor - pig >... 91 1e-17
pir||F72247 methionine aminopeptidase - Thermotoga maritima (str... 90 3e-17
dbj|BAA88830.1| (AB016788) creatine amidinohydrolase [Alcaligene... 90 3e-17
gi|10955071 agcA [Agrobacterium tumefaciens] >gi|2329863|emb|CAA... 90 3e-17
pir||E71651 hypothetical protein RP482 - Rickettsia prowazekii >... 90 4e-17
sp|Q9Z6Q0|AMPM_CHLPN METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 90 4e-17
pir||A81531 methionine aminopeptidase CP0844 [imported] - Chlamy... 90 4e-17
pir||C82367 aminopeptidase P VC0067 [imported] - Vibrio cholerae... 89 6e-17
gb|AAD27841.1|AF124600_4 (AF124600) putative cytoplasmic peptida... 89 8e-17
sp|P55666|Y4TL_RHISN HYPOTHETICAL HYDROLASE/PEPTIDASE Y4TL >gi|2... 89 1e-16
gb|AAD37463.1| (AF072304) creatinase [Pseudomonas putida] 86 5e-16
emb|CAA19220.1| (AL023653) dJ753P9.1 (Aminopeptidase P (EC 3.4.1... 86 5e-16
gi|10880126 X-prolyl aminopeptidase 2, membrane-bound; aminoacyl... 86 5e-16
gb|AAD52565.4|AF170566_1 (AF170566) creatinase [Pseudomonas putida] 85 9e-16
sp|Q9Z9J4|AMPM_BACHD METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 85 9e-16
gi|11420265 X-prolyl aminopeptidase 2, membrane-bound [Homo sapi... 84 3e-15
pir||C70108 peptidase homolog - Lyme disease spirochete >gi|2687... 83 3e-15
pir||T32753 hypothetical protein W03G9.4 - Caenorhabditis elegan... 83 3e-15
gb|AAC16431.1| (AF063007) similar to the peptidase family M; Pfa... 83 4e-15
sp|O66489|AMPM_AQUAE METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 82 7e-15
dbj|BAA95761.1| (AB028607) methionine aminopeptidase-like protei... 82 7e-15
gb|AAF69574.1|AC013257_1 (AC013257) Proline dipeptidase [Leishma... 82 7e-15
sp|P19213|CREA_FLASU CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|... 80 3e-14
gb|AAB82638.1| (AC002387) putative methionine aminopeptidase [Ar... 80 4e-14
dbj|BAB03321.1| (AB035448) methionin aminopeptidase [Staphylococ... 80 4e-14
gb|AAG33976.1|AF250962_1 (AF250962) methionine aminopeptidase-li... 80 4e-14
sp|P19994|AMPM_BACSU METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 80 5e-14
pdb|1CHM|B Chain B, Creatine Amidinohydrolase (E.C.3.5.3.3) 78 1e-13
sp|P38488|CREA_PSEPU CREATINASE (CREATINE AMIDINOHYDROLASE) 78 1e-13
pdb|1CHM|A Chain A, Creatine Amidinohydrolase (E.C.3.5.3.3) 78 1e-13
pir||C75410 methionine aminopeptidase - Deinococcus radiodurans ... 78 1e-13
pir||T34903 methionine aminopeptidase - Streptomyces coelicolor ... 77 2e-13
gb|AAG33975.1|AF250961_1 (AF250961) methionine aminopeptidase-li... 77 2e-13
sp|P53582|AMP1_HUMAN PUTATIVE METHIONINE AMINOPEPTIDASE 1 (METAP... 75 1e-12
sp|Q9ZCD3|AMPM_RICPR METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 75 1e-12
gb|AAG09564.1|AC011810_23 (AC011810) Putative methionine aminope... 75 1e-12
gb|AAG33977.1|AF250963_1 (AF250963) methionine aminopeptidase-li... 75 1e-12
emb|CAB16790.1| (Z99707) methionyl aminopeptidase-like protein [... 75 1e-12
pir||T50575 methionyl aminopeptidase (EC 3.4.11.18) [imported] -... 73 6e-12
pir||D82097 methionine aminopeptidase VC2261 [imported] - Vibrio... 73 6e-12
gb|AAF56327.1| (AE003749) CG13630 gene product [Drosophila melan... 72 8e-12
emb|CAA38501.1| (X54687) pepQ product, proline dipeptidase [Esch... 72 1e-11
pir||S30738 X-Pro dipeptidase (EC 3.4.13.9) - Escherichia coli >... 72 1e-11
sp|P21165|PEPQ_ECOLI XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PR... 72 1e-11
sp|P07906|AMPM_ECOLI METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 71 1e-11
pdb|2MAT|A Chain A, E.Coli Methionine Aminopeptidase At 1.9 Angs... 71 1e-11
pdb|1C22|A Chain A, E. Coli Methionine Aminopeptidase: Trifluoro... 71 1e-11
pdb|3MAT|A Chain A, E.Coli Methionine Aminopeptidase Transition-... 71 1e-11
pdb|4MAT|A Chain A, E.Coli Methionine Aminopeptidase His79ala Mu... 71 1e-11
sp|P53581|AMP3_SYNY3 PUTATIVE METHIONINE AMINOPEPTIDASE C (MAP) ... 71 2e-11
gi|6323273 methionine aminopeptidase; Map1p [Saccharomyces cerev... 70 4e-11
gi|6322999 Yll029wp [Saccharomyces cerevisiae] >gi|2131729|pir||... 70 4e-11
gb|AAF33408.1| (AF233324) 95% identity with E. coli proline dipe... 70 4e-11
>pir||E75088 cobalt-dependent proline dipeptidase (pepq-2) PAB1637 - Pyrococcus
abyssi (strain Orsay) >gi|5458522|emb|CAB50010.1|
(AJ248286) cobalt-dependent proline dipeptidase
(pepQ-2) [Pyrococcus abyssi]
Length = 351
Score = 695 bits (1773), Expect = 0.0
Identities = 351/351 (100%), Positives = 351/351 (100%)
Query: 1 MNIMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELE 60
MNIMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELE
Sbjct: 1 MNIMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELE 60
Query: 61 YEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDV 120
YEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDV
Sbjct: 61 YEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDV 120
Query: 121 IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA 180
IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA
Sbjct: 121 IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA 180
Query: 181 FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI 240
FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI
Sbjct: 181 FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI 240
Query: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVS 300
YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVS
Sbjct: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVS 300
Query: 301 QYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
QYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI
Sbjct: 301 QYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
>pir||G71056 probable X-Pro dipeptidase - Pyrococcus horikoshii
>gi|3257566|dbj|BAA30249.1| (AP000005) 351aa long
hypothetical X-Pro dipeptidase [Pyrococcus horikoshii]
Length = 351
Score = 610 bits (1555), Expect = e-173
Identities = 295/351 (84%), Positives = 329/351 (93%)
Query: 1 MNIMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELE 60
M+IM+EK+K+IIEFM++NSIDAVLI KNPN+YY+SGASPLAGGYIL+ + ATLYVPELE
Sbjct: 1 MDIMNEKVKKIIEFMDKNSIDAVLIAKNPNVYYISGASPLAGGYILITGESATLYVPELE 60
Query: 61 YEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDV 120
YEMAKEES IPVEKFK+ D+FYK EG+K LGIE SL Y F+E+LK+K I EFKKVDDV
Sbjct: 61 YEMAKEESNIPVEKFKKMDEFYKALEGIKSLGIESSLPYGFIEELKKKANIKEFKKVDDV 120
Query: 121 IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA 180
I++MRI+KS++EIKIIEKACEIADKAVMAAIEE+TEGKKERE+AAKVEYLMKMNGAEKPA
Sbjct: 121 IRDMRIIKSEKEIKIIEKACEIADKAVMAAIEEITEGKKEREVAAKVEYLMKMNGAEKPA 180
Query: 181 FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI 240
FDTIIASGYRSALPHGVASDKRIE+GDLVVIDLGALY HYNSDITRT+VVGSPNEKQ+EI
Sbjct: 181 FDTIIASGYRSALPHGVASDKRIERGDLVVIDLGALYQHYNSDITRTIVVGSPNEKQKEI 240
Query: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVS 300
YEIVLEAQKKAVE+A+PGIT KELDSIARNII EYGYG+YF HSLGHGVGLE+HEWP VS
Sbjct: 241 YEIVLEAQKKAVESAKPGITAKELDSIARNIIAEYGYGEYFNHSLGHGVGLEVHEWPRVS 300
Query: 301 QYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
QYDETVL+EGMVITIEPGIYIPK GGVRIEDTI+ITK G++RLTKTERELI
Sbjct: 301 QYDETVLREGMVITIEPGIYIPKIGGVRIEDTILITKNGSKRLTKTERELI 351
>pir||T46973 X-Pro dipeptidase (EC 3.4.13.9), cobalt dependent [validated] -
Pyrococcus furiosus (fragment)
>gi|3372642|gb|AAC61259.1| (AF060010) proline
dipeptidase [Pyrococcus furiosus]
Length = 348
Score = 579 bits (1476), Expect = e-164
Identities = 277/348 (79%), Positives = 319/348 (91%)
Query: 4 MDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEM 63
M E+++++++FM+ENSID V I K N+YY SG SPL GGYI+V+ D ATLYVPELEYEM
Sbjct: 1 MKERLEKLVKFMDENSIDRVFIAKPVNVYYFSGTSPLGGGYIIVDGDEATLYVPELEYEM 60
Query: 64 AKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDVIKE 123
AKEESK+PV KFK+ D+ Y++ + + LGIEG+LSYS VE+ KEK + EFKK+DDVIK+
Sbjct: 61 AKEESKLPVVKFKKFDEIYEILKNTETLGIEGTLSYSMVENFKEKSNVKEFKKIDDVIKD 120
Query: 124 MRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDT 183
+RI+K+ EEI+IIEKACEIADKAVMAAIEE+TEGK+ERE+AAKVEYLMKMNGAEKPAFDT
Sbjct: 121 LRIIKTKEEIEIIEKACEIADKAVMAAIEEITEGKREREVAAKVEYLMKMNGAEKPAFDT 180
Query: 184 IIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEI 243
IIASG+RSALPHGVASDKRIE+GDLVVIDLGALYNHYNSDITRT+VVGSPNEKQREIYEI
Sbjct: 181 IIASGHRSALPHGVASDKRIERGDLVVIDLGALYNHYNSDITRTIVVGSPNEKQREIYEI 240
Query: 244 VLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD 303
VLEAQK+AVEAA+PG+T KELDSIAR IIKEYGYGDYFIHSLGHGVGLEIHEWP +SQYD
Sbjct: 241 VLEAQKRAVEAAKPGMTAKELDSIAREIIKEYGYGDYFIHSLGHGVGLEIHEWPRISQYD 300
Query: 304 ETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
ETVLKEGMVITIEPGIYIPK GGVRIEDT++IT+ GA+RLTKTEREL+
Sbjct: 301 ETVLKEGMVITIEPGIYIPKLGGVRIEDTVLITENGAKRLTKTERELL 348
>dbj|BAB06519.1| (AP001516) Xaa-Pro dipeptidase [Bacillus halodurans]
Length = 355
Score = 279 bits (706), Expect = 3e-74
Identities = 152/351 (43%), Positives = 216/351 (61%), Gaps = 8/351 (2%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKE 66
+++RI ++E+ D +LI N Y++ + AG I+ GA +++ + Y E
Sbjct: 3 RLERIRAAIHEHDFDGLLIMSPYNRRYVTEFTGTAGAAIVTG--GAAIFITDFRYVEQAE 60
Query: 67 ESKIPVEKFKRRDDFYKVFE------GVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDV 120
E + K ++ G++ LG E S +L K SE V +
Sbjct: 61 EQARGFDIVKHTGTIFEEIANQAKKLGIQKLGFEKSHVTFETYELLNKLVDSELVPVAGL 120
Query: 121 IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA 180
++ +R++K + E++I+++A IAD A + G ERE+A ++E+ M+ GAE +
Sbjct: 121 VENIRLIKDETELQIMQEAANIADAAFAHITSYIRAGVTEREVANELEFFMRKQGAESSS 180
Query: 181 FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI 240
FD I+ASGYRSALPHGVASDK IEKG+LV +D GA Y Y SDITRTV VG N++ R+I
Sbjct: 181 FDIIVASGYRSALPHGVASDKVIEKGELVTLDFGAYYKGYCSDITRTVAVGDINDELRKI 240
Query: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVS 300
Y+ VLEAQ K +E +PGIT KE D++ R+ I GYG+YF HS GHG+GLE+HE PG+S
Sbjct: 241 YDTVLEAQLKGMEGIKPGITGKEADALTRDHITAKGYGEYFGHSTGHGLGLEVHEGPGLS 300
Query: 301 QYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
+ VLK GMV+T+EPGIYI GG RIED VIT++G R LTK+ +EL+
Sbjct: 301 MKSKAVLKPGMVVTVEPGIYISGVGGTRIEDDTVITESGNRSLTKSPKELL 351
>sp|P54518|YQHT_BACSU PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INTERGENIC REGION
>gi|7430115|pir||C69960 Xaa-Pro dipeptidase homolog yqhT
- Bacillus subtilis >gi|1303901|dbj|BAA12557.1| (D84432)
YqhT [Bacillus subtilis] >gi|2634880|emb|CAB14377.1|
(Z99116) similar to Xaa-Pro dipeptidase [Bacillus
subtilis]
Length = 353
Score = 278 bits (703), Expect = 8e-74
Identities = 148/355 (41%), Positives = 223/355 (62%), Gaps = 15/355 (4%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKE 66
K++++ + ID +LIT N N+ Y++G + AG ++ + A ++ + Y E
Sbjct: 2 KLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGDKAA--FITDFRYT---E 56
Query: 67 ESKIPVEKFKRRDDFYKVFE---------GVKVLGIE-GSLSYSFVEDLKEKGKISEFKK 116
++K+ V+ F+ + + + G+K LG E S++Y +E
Sbjct: 57 QAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTYASYSAVISDAELVP 116
Query: 117 VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA 176
V + ++++R++KS EEIKI+E+A +IAD A + + G E +A ++E+ M+ GA
Sbjct: 117 VAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISEIAVANELEFYMRSQGA 176
Query: 177 EKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
+ +FD I+ASG RS+LPHGVASDK IE GDLV +D GA Y Y SDITRTV VG P+++
Sbjct: 177 DSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYKGYCSDITRTVAVGQPSDQ 236
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEW 296
+EIY++V +AQ V +PG+T KE D++ R+ I GYGDYF HS GHG+G+E+HE
Sbjct: 237 LKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKGYGDYFGHSTGHGLGMEVHES 296
Query: 297 PGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
PG+S +L+ GMV+T+EPGIYIP+ GGVRIED IVIT+ G R +T + +ELI
Sbjct: 297 PGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIVITENGNRTITHSPKELI 351
>pir||G72425 hypothetical protein TM0042 - Thermotoga maritima (strain MSB8)
>gi|4980527|gb|AAD35136.1|AE001691_10 (AE001691)
aminopeptidase P, putative [Thermotoga maritima]
Length = 359
Score = 265 bits (671), Expect = 4e-70
Identities = 144/356 (40%), Positives = 227/356 (63%), Gaps = 12/356 (3%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGA--SPLAGGY-ILVNNDGATLYVPELEYE 62
++ +R+I+ ++E IDA LI N S S G + I++ ++ L + + Y
Sbjct: 2 DRSERLIQLISEEGIDAFLIMNIENSARASSVYFSGFTGSFSIILISENTRLLITDSRYT 61
Query: 63 M-AKEESKIPVEKFKRRDDFYKVFEG------VKVLGIEGS-LSYSFVEDLKEKGKISEF 114
+ AK+E+ V + K DF V + +K + +E +S S + +F
Sbjct: 62 VQAKQETDFEVREVKG-GDFIDVLKKTVNDLKIKTIALEEERVSLSLFRRISSAFGDRKF 120
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
+DD +K+MR+VK + EI+ I++A EI+++A + ++++ G E+EIAA +EY M+
Sbjct: 121 IGIDDEVKQMRMVKDEGEIEKIKQAIEISERAFLETVQQIRAGMTEKEIAALLEYTMRKE 180
Query: 175 GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPN 234
GAE AFDTI+ASG RSALPHG ASDK +E+GD++VID GA Y +Y +DITR V +G P+
Sbjct: 181 GAEGVAFDTIVASGCRSALPHGKASDKVVERGDVIVIDFGATYENYCADITRVVSIGEPS 240
Query: 235 EKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIH 294
++ +E++ IVLEAQ++A++ A+ G+T K LDS+AR I+E GYG++F HSLGHG+GLE+H
Sbjct: 241 DEVKEVHSIVLEAQERALKIAKAGVTGKLLDSVAREFIREKGYGEFFGHSLGHGIGLEVH 300
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTEREL 350
E P +S +++ L E +V T+EPGIY+ G+RIE+ +V+ + G LT R +
Sbjct: 301 EGPAISFRNDSPLPENVVFTVEPGIYLEGKFGIRIEEDVVLKEQGCEILTTLPRSI 356
>emb|CAA70068.1| (Y08842) aminopeptidase P [Lactococcus lactis]
Length = 352
Score = 256 bits (646), Expect = 4e-67
Identities = 144/353 (40%), Positives = 217/353 (60%), Gaps = 13/353 (3%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEY-EMA 64
EK+K ++ + EN ID++LIT NI+YL+G S AG L +++ + Y EMA
Sbjct: 4 EKLK--VKMLTEN-IDSLLITDMKNIFYLTGFSGTAGTVFLTQK--RNIFMTDSRYSEMA 58
Query: 65 KEESKIPVEKFKRRDDF-----YKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDD 119
+ K E + RD E VK + E ++ Y+F + L + + +
Sbjct: 59 RGLIK-NFEIIETRDPISLLTELSASESVKNMAFEETVDYAFFKRLSKAATKLDLFSTSN 117
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
+ E+R +K + EI +I+KACEIAD+A M+A+ + G+ E E+A +++ M+ A
Sbjct: 118 FVLELRQIKDESEISLIKKACEIADEAFMSALRFIEPGRTEIEVANFLDFKMRDLEASGI 177
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQRE 239
+F+TI+ASG RS+LPHGVA+ K I+ GD V ID G Y HY SD+TRT+ VGS ++K R
Sbjct: 178 SFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRT 237
Query: 240 IYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGV 299
IYE V +A + ++ + G+T + D+I R +I++ +G YF H +GHG+GL++HE P
Sbjct: 238 IYETVRKANEALIKQVKAGMTYAQYDNIPREVIEKADFGQYFTHGIGHGLGLDVHEIPYF 297
Query: 300 SQ-YDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
+Q E L+ GMVIT EPGIY+P+FGGVRIED +++T+ G LTK +ELI
Sbjct: 298 NQSMTENQLRSGMVITDEPGIYLPEFGGVRIEDDLLVTENGCEVLTKAPKELI 350
>pir||D75419 proline dipeptidase - Deinococcus radiodurans (strain R1)
>gi|6458990|gb|AAF10817.1|AE001972_7 (AE001972) proline
dipeptidase [Deinococcus radiodurans]
Length = 349
Score = 247 bits (623), Expect = 2e-64
Identities = 136/348 (39%), Positives = 209/348 (59%), Gaps = 4/348 (1%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKE 66
K+ ++ + +DA+ ++ N+ +LSG + G +LV+ DGATLY A+E
Sbjct: 3 KMDQLRPVLGRAGVDALWVSAPANVRWLSGFTSAEDGKVLVSPDGATLYTDARYTVQAQE 62
Query: 67 ESKIPVEKFKRRDDFYKVFEGVKVL--GIEG-SLSYSFVEDLKEKGKISEFKKVDDVIKE 123
ES +P + + + V+ L G E SL+ + +EDL++ S + +
Sbjct: 63 ESSLPQYIARPPATYEHAADTVRGLRVGFEAESLTVAELEDLRQAWPNSTLVALRGTLGG 122
Query: 124 MRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDT 183
+R VK+ EEI I A ++AD+ + G +E ++A ++E ++ G E AF+
Sbjct: 123 LRAVKTPEEIGAIRAAQDLADRVYTEVRPMIRAGVRELDVAVEIETRLRRAGGES-AFEL 181
Query: 184 IIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEI 243
I+ASG A PHG AS + IE GDLV ID+GA YNSD+TRTV VG+P+ + + +Y+
Sbjct: 182 IVASGPNGAKPHGHASKRVIEDGDLVTIDMGARLGGYNSDMTRTVAVGTPSAEMKRVYDA 241
Query: 244 VLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD 303
VLEA++ A+ A RPG+ +LD +AR+++ +G G+ F HSLGHGVGLE+HE PG+
Sbjct: 242 VLEAEEAAIAAIRPGVRAADLDKLARDLLTRHGLGEAFAHSLGHGVGLEVHEGPGLRGTS 301
Query: 304 ETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
+ VL+ GMVITIEPG Y+P GGVRIED I++T+ G L+ + +E +
Sbjct: 302 QDVLEAGMVITIEPGAYLPGVGGVRIEDLILVTEDGYEVLSHSAKESV 349
>sp|Q58216|Y806_METJA HYPOTHETICAL PEPTIDASE MJ0806 >gi|2129355|pir||F64400 X-Pro
dipeptidase (EC 3.4.13.9) - Methanococcus jannaschii
>gi|1591498|gb|AAB98806.1| (U67525) X-pro aminopeptidase
(pepQ) [Methanococcus jannaschii]
Length = 347
Score = 242 bits (610), Expect = 6e-63
Identities = 137/353 (38%), Positives = 222/353 (62%), Gaps = 23/353 (6%)
Query: 2 NIMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEY 61
+IM+ +I+R +++M I +I K NI Y G ++ +LV + LYV +L+
Sbjct: 7 DIMNNRIERFLKYMESEGIKKAVILKKENINYFLGKYFMSFS-VLVFEEQPYLYVGKLDK 65
Query: 62 EMAKEESK-IPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDV 120
+ A+E + + +FK ++ +K +GV E LS +++ + + E+K + D
Sbjct: 66 DYAEEHFNFLEIREFKSWEEIFKGCDGV-----EKELSIGYLKYIDK-----EYKIISDK 115
Query: 121 IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKK--EREIAAKVEYLMKMNGAEK 178
IKEMR++K EEIK+I+KA EI+DKA+ + + E K E E+ A++EY+MK +G+ K
Sbjct: 116 IKEMRMIKDKEEIKLIKKAAEISDKAINWVLNNLDEVKNLTEYELVAEIEYIMKKHGSIK 175
Query: 179 PAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQR 238
PAFD+I+ SG +++ PH + + +I D++++D+GA+Y Y SDITRT ++ +E+ +
Sbjct: 176 PAFDSIVVSGKKTSFPHALPTKDKI--ADILLVDIGAVYEGYCSDITRTFLL-KDDEEMK 232
Query: 239 EIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPG 298
+IY +V EA+K A E + GI+ K++D+I R +Y + FIHSLGHGVGLE+HE P
Sbjct: 233 KIYNLVYEAKKVAEEHLKEGISAKQIDNIVREFFNDYK--ELFIHSLGHGVGLEVHEEPR 290
Query: 299 VSQY----DETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTE 347
+S ++ +LKEGMV+TIEPG+Y+ GVRIED ++ K G +L+K E
Sbjct: 291 LSNKLKDDEDIILKEGMVVTIEPGLYLKDKFGVRIEDLYLVKKNGFEKLSKAE 343
>pir||G69869 Xaa-Pro dipeptidase homolog ykvY - Bacillus subtilis
>gi|2633757|emb|CAB13259.1| (Z99111) similar to Xaa-Pro
dipeptidase [Bacillus subtilis]
Length = 363
Score = 241 bits (608), Expect = 1e-62
Identities = 129/359 (35%), Positives = 208/359 (57%), Gaps = 14/359 (3%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSG----ASPLAGGYILVNNDGATLYVPELEYE 62
+I+R+ ++ E A I N++YL+G G + + P +E
Sbjct: 3 RIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGLFIFQEEEPFFVCPGMEAG 62
Query: 63 MAKEES-KIPVEKFKRRDDFYKVFE--------GVKVLGIE-GSLSYSFVEDLKEKGKIS 112
A+ + + ++ +++ E + +L +E S+S S E LK +
Sbjct: 63 QARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAVEKDSISLSRAEQLKHATGGA 122
Query: 113 EFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMK 172
+F ++ + + R++K D EI+++++A ++AD V + EG E E+ A++EY +K
Sbjct: 123 QFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVGTAALREGISEVEVLAQIEYELK 182
Query: 173 MNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGS 232
G + +F T++ G +S PHG ++KGD V+ DLG + + Y SDITRT +
Sbjct: 183 KKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDFVLFDLGVILDGYCSDITRTFAYKT 242
Query: 233 PNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLE 292
N KQ IYE VL+A+K A+EA++PG+ +LD AR II++ GYGDYF H LGHG+G+
Sbjct: 243 INPKQEAIYETVLQAEKAAIEASKPGVRIGDLDLTARGIIEKAGYGDYFPHRLGHGLGIS 302
Query: 293 IHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
+HE+P +SQ ++T+L+EGMV TIEPGIY+P+ GGVRIED + +TK GA LT+ ++LI
Sbjct: 303 VHEYPSMSQANDTLLQEGMVYTIEPGIYVPEIGGVRIEDDVHVTKDGAVALTQYPKDLI 361
>pir||A71089 probable dipeptidase - Pyrococcus horikoshii
>gi|3257388|dbj|BAA30071.1| (AP000004) 356aa long
hypothetical dipeptidase [Pyrococcus horikoshii]
Length = 356
Score = 241 bits (608), Expect = 1e-62
Identities = 138/357 (38%), Positives = 214/357 (59%), Gaps = 16/357 (4%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGG----YILVNNDGATLYVPELEYE 62
++++ I + E D LI+ N+YYL+G G + V+ +G ++ YE
Sbjct: 2 RLEKFIHLLGERGFDGALISPGTNLYYLTGLRLHEVGERLAILAVSAEGDYRFLAPSLYE 61
Query: 63 MAKEESKIPVEKFKRRDDFY-KVFEGVKVLGI-------EGSLSYSFVEDLKEKGKISEF 114
+ P + ++ Y K+ E ++ LGI E ++ ++ + + GK + F
Sbjct: 62 NVV--NNFPATFWHDGENPYAKLREILEELGISKGRILIEDTMRADWLIGIMKLGKFT-F 118
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
+ + +IKE+R++K EE+K++E A IADK + G KERE+A K+E L++
Sbjct: 119 QPLSSLIKELRMIKDKEEVKMMEHASRIADKVFEEILTWDLIGMKERELALKIELLIR-E 177
Query: 175 GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPN 234
++ AF+ I+ASG +A PH +++I KGD++++D GA + Y SDITRT+ +G +
Sbjct: 178 LSDGIAFEPIVASGENAANPHHEPGERKIRKGDIIILDYGARWKGYCSDITRTIGLGELD 237
Query: 235 EKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIH 294
E+ +IYE+V +AQ+ A +A R GI K++DS AR +I + GYG+YFIH GHG+GL++H
Sbjct: 238 ERLVKIYEVVKDAQESAFKAVREGIKAKDVDSRAREVISKAGYGEYFIHRTGHGLGLDVH 297
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
E P + E +LK GM TIEPGIY+P GGVRIED IV+ + RRLTK ERELI
Sbjct: 298 EEPYIGPDGEVILKNGMTFTIEPGIYVPGLGGVRIEDDIVVDEGKGRRLTKAERELI 354
>emb|CAC12166.1| (AL445066) proline dipeptidase related protein [Thermoplasma
acidophilum]
Length = 360
Score = 238 bits (602), Expect = 5e-62
Identities = 137/350 (39%), Positives = 201/350 (57%), Gaps = 16/350 (4%)
Query: 8 IKRIIEFMNENSIDAVLI------TKNPNIYYLSGASP--LAGGYILVNNDGATLYVPEL 59
++R+ E+ E +D +LI ++P Y++ + G ++V +G T+ +L
Sbjct: 3 VERVFEYARE--VDTLLIYNASESARDPTFTYVTQTTNGIFEGSALIVGKNGTTIVTSQL 60
Query: 60 EYEMAKEESKIPVEKFKRRDDFYKVFE----GVKVLGIE-GSLSYSFVEDLKEKGKISEF 114
E E A + + V FK DF + V +G+ SLS S + L EF
Sbjct: 61 E-EQAARATGLDVRIFKNSTDFQNILRELLRDVNTVGLNYQSLSLSSYKMLLRIVPDKEF 119
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
V I E R +K EE+K I +A +I + + ++ + EG E E+A+K+ YLM N
Sbjct: 120 LDVSASILEARKIKQAEELKKIREAAKIGSEVLPDVLDSLKEGMTEYEVASKIVYLMMKN 179
Query: 175 GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPN 234
GA P+FDTI+A G +A+PH ++++GD V++D GA Y Y SDITRTVV G
Sbjct: 180 GASGPSFDTIVAFGQNAAMPHYSPGQAKLKRGDFVLMDYGARYMGYCSDITRTVVFGKAT 239
Query: 235 EKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIH 294
E+Q+E+Y V EAQ ++A R G K++D+ ARNII Y FIHSLGHGVGLE+H
Sbjct: 240 EEQKEMYNTVKEAQAAGMKAIREGANGKDVDAAARNIIDSTKYKGRFIHSLGHGVGLEVH 299
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLT 344
+ P +S + LK MV+T+EPGIY+P +GGVRIED +V+TK G ++T
Sbjct: 300 DHPALSPTMDFPLKANMVVTVEPGIYVPGYGGVRIEDDVVVTKEGYEKIT 349
>pir||D69231 probable X-Pro dipeptidase (EC 3.4.13.9) - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622080|gb|AAB85477.1| (AE000871) aminopeptidase P
[Methanobacterium thermoautotrophicum]
Length = 336
Score = 232 bits (586), Expect = 4e-60
Identities = 137/329 (41%), Positives = 205/329 (61%), Gaps = 16/329 (4%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKE 66
+I+ +E ++E + LIT NIYYLSG P A ++++ D L V E++ E A
Sbjct: 11 RIECALENIHEEG-ERALITARKNIYYLSGFMPTATSFLILE-DEPVLLVSEMDRESAMA 68
Query: 67 ESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDVIKEMRI 126
+S++ V FKR D + F+ VL +E + +E L G +V D + ++R+
Sbjct: 69 KSRVDVRTFKRIRDVRESFDLSGVL-VEPATPVGLLERLGIGGDF----RVMDPVSDIRM 123
Query: 127 VKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTIIA 186
VK EE+K +E+A IA+ + +++ E EIAA+++Y M++ G+E +FDTI+A
Sbjct: 124 VKDREELKRMEEALRIAENS----FKKLEFNGTEIEIAARLDYTMRLAGSEGVSFDTIVA 179
Query: 187 SGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLE 246
S RS++PH V + IE V+ID GA+ Y+SD TRT+V G E + E+ EIVLE
Sbjct: 180 SSERSSIPHAVPTANTIESP--VLIDWGAVREGYHSDTTRTIVEG---EGEHEVLEIVLE 234
Query: 247 AQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYDETV 306
A++ V+A +PG ++DS R +I EYGY D FIHS GHGVGL++HE P ++ DETV
Sbjct: 235 AKRAGVKALKPGARACDVDSAVRGVIGEYGYADNFIHSTGHGVGLDVHEKPSLAAGDETV 294
Query: 307 LKEGMVITIEPGIYIPKFGGVRIEDTIVI 335
L++GMV+T+EPGIYIP GVR+ED +V+
Sbjct: 295 LRKGMVLTVEPGIYIPGEFGVRVEDMVVV 323
>pir||C75134 x-pro aminopeptidase (pepq-3) PAB1781 - Pyrococcus abyssi (strain
Orsay) >gi|5458299|emb|CAB49788.1| (AJ248285) X-pro
aminopeptidase (pepQ-3) [Pyrococcus abyssi]
Length = 355
Score = 230 bits (581), Expect = 2e-59
Identities = 138/357 (38%), Positives = 202/357 (55%), Gaps = 17/357 (4%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGG----YILVNNDGA-TLYVPELEY 61
+I R ++ +NE + D I+ N+YYL+G G ++V+ DG L P L
Sbjct: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
Query: 62 EMAKE-------ESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEF 114
+ + + P K K++ G + +E ++ ++ + + G EF
Sbjct: 62 NVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFL--VEDTMRADWLIGILKLGNF-EF 118
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
+ +I+ MR+ K EEI+ ++ A IADK + G E+E+A K+E ++
Sbjct: 119 HPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIR-E 177
Query: 175 GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPN 234
++ +F I+ASG SA PH +++I KGD+V++D GA + Y SDITRT+ VG P+
Sbjct: 178 LSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPD 237
Query: 235 EKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIH 294
EK E+YEIV EAQ+KA A R GI KE+D +AR +I E GYG+YF H GHG+GL++H
Sbjct: 238 EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVH 297
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
E P + E L+ GM TIEPGIYIP GGVRIED +V+ G +RLTK RELI
Sbjct: 298 EEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAGRELI 353
>emb|CAB07978.1| (Z93944) prolidase [Lactobacillus delbrueckii]
Length = 368
Score = 229 bits (577), Expect = 5e-59
Identities = 134/364 (36%), Positives = 205/364 (55%), Gaps = 26/364 (7%)
Query: 8 IKRIIEFMNENSIDAVLITKNPNIYYLSG--ASPLAGGYILVNNDGAT--LYVPELEYEM 63
+ ++ ++ EN +D ++ I Y +G P + L A L+ P L YE
Sbjct: 3 LDKLQNWLQENGMDVAYVSSPTTINYFTGFITDPEERIFKLFAFKDAEPFLFCPALNYEE 62
Query: 64 AKE-----------ESKIP----VEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEK 108
AK +S+ P E+ K+R Y+ + K L+ + + L +
Sbjct: 63 AKASAWDGDVVGYLDSEDPWGKIAEEIKQRSKDYQNWAVEK-----NGLTVAHYQALHAQ 117
Query: 109 GKISEFKK-VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKV 167
S+F K + D I +R+ K++ E+ + KA E AD A E + G ER + +++
Sbjct: 118 FPDSDFSKDLSDFIAHIRLFKTESELVKLRKAGEEADFAFQIGFEALRNGVTERAVVSQI 177
Query: 168 EYLMKMN-GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITR 226
EY +K+ G + +FDTI+ +G +A PH S ++ +LV+ DLG ++ Y SD +R
Sbjct: 178 EYQLKLQKGVMQTSFDTIVQAGKNAANPHQGPSMNTVQPNELVLFDLGTMHEGYASDSSR 237
Query: 227 TVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLG 286
TV G P +K REIYE+ AQ+ A++AA+PG+T ELD +AR II + GYG+YFIH LG
Sbjct: 238 TVAYGEPTDKMREIYEVNRTAQQAAIDAAKPGMTASELDGVARKIITDAGYGEYFIHRLG 297
Query: 287 HGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKT 346
HG+G+E+HE+P ++ ++ VL+EGM +IEPGIYIP F GVRIED V+TK G + T T
Sbjct: 298 HGIGMEVHEFPSIANGNDVVLEEGMCFSIEPGIYIPGFAGVRIEDCGVLTKEGFKPFTHT 357
Query: 347 EREL 350
+EL
Sbjct: 358 SKEL 361
>sp|P46545|PEPQ_LACDL XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE) >gi|1075982|pir||S52202
X-Pro dipeptidase (EC 3.4.13.9) [validated] -
Lactobacillus delbrueckii >gi|609078|emb|CAA84379.1|
(Z34896) prolidase [Lactobacillus delbrueckii]
>gi|1150454|emb|CAA90911.1| (Z54205) prolidase PepQ
[Lactobacillus delbrueckii]
Length = 368
Score = 229 bits (577), Expect = 5e-59
Identities = 135/365 (36%), Positives = 204/365 (54%), Gaps = 28/365 (7%)
Query: 8 IKRIIEFMNENSIDAVLITKNPNIYYLSG--ASPLAGGYILVNNDGAT--LYVPELEYEM 63
+ ++ ++ EN +D ++ I Y +G P + L A L+ P L YE
Sbjct: 3 LDKLQNWLQENGMDVAYVSSPTTINYFTGFITDPEERIFKLFAFKDAEPFLFCPALNYEE 62
Query: 64 AKEE----------------SKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKE 107
AK SKI E+ K+R Y+ + K L+ + + L
Sbjct: 63 AKASAWDGDVVGYLDSEDPWSKI-AEEIKKRTKDYQNWAVEK-----NGLTVAHYQALHA 116
Query: 108 KGKISEFKK-VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAK 166
+ S+F K + D I +R+ K++ E+ + KA E AD A E + G ER + ++
Sbjct: 117 QFPDSDFSKDLSDFIAHIRLFKTESELVKLRKAGEEADFAFQIGFEALRNGVTERAVVSQ 176
Query: 167 VEYLMKMN-GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDIT 225
+EY +K+ G + +FDTI+ +G +A PH S ++ +LV+ DLG ++ Y SD +
Sbjct: 177 IEYQLKLQKGVMQTSFDTIVQAGKNAANPHQGPSMNTVQPNELVLFDLGTMHEGYASDSS 236
Query: 226 RTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSL 285
RTV G P +K REIYE+ AQ+ A++AA+PG+T ELD +AR II + GYG+YFIH L
Sbjct: 237 RTVAYGEPTDKMREIYEVNRTAQQAAIDAAKPGMTASELDGVARKIITDAGYGEYFIHRL 296
Query: 286 GHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTK 345
GHG+G+E+HE+P ++ ++ VL+EGM +IEPGIYIP F GVRIED V+TK G + T
Sbjct: 297 GHGIGMEVHEFPSIANGNDVVLEEGMCFSIEPGIYIPGFAGVRIEDCGVLTKDGFKPFTH 356
Query: 346 TEREL 350
T +EL
Sbjct: 357 TSKEL 361
>sp|Q9S6S1|PEPQ_LACDE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE)
>gi|3821250|emb|CAA73815.1| (Y13385) proline dipeptidase
[Lactobacillus delbrueckii subsp. bulgaricus]
Length = 368
Score = 228 bits (576), Expect = 6e-59
Identities = 134/364 (36%), Positives = 205/364 (55%), Gaps = 26/364 (7%)
Query: 8 IKRIIEFMNENSIDAVLITKNPNIYYLSG--ASPLAGGYILVNNDGAT--LYVPELEYEM 63
+ ++ ++ EN +D ++ I Y +G P + L A L+ P L YE
Sbjct: 3 LDKLQNWLQENGMDVAYVSSPTTINYFTGFITDPEERIFKLFAFKDAEPFLFCPALNYEE 62
Query: 64 AKE-----------ESKIP----VEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEK 108
AK +S+ P E+ K+R Y+ + K L+ + + L +
Sbjct: 63 AKASAWDGDVVGYLDSEDPWGKIAEEIKQRTKDYQNWAVEK-----NGLTVAHYQALHAQ 117
Query: 109 GKISEFKK-VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKV 167
S+F K + D I +R+ K++ E+ + KA E AD A E + G ER + +++
Sbjct: 118 FPDSDFSKDLSDFIAHIRLFKTESELVKLRKAGEEADFAFQIGFEALRNGVTERAVVSQI 177
Query: 168 EYLMKMN-GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITR 226
EY +K+ G + +FDTI+ +G +A PH S ++ +LV+ DLG ++ Y SD +R
Sbjct: 178 EYQLKLQKGVMQTSFDTIVQAGKNAANPHQGPSMNTVQPNELVLFDLGTMHEGYASDSSR 237
Query: 227 TVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLG 286
TV G P +K REIYE+ AQ+ A++AA+PG+T ELD +AR II + GYG+YFIH LG
Sbjct: 238 TVAYGEPTDKMREIYEVNRTAQQAAIDAAKPGMTASELDGVARKIITDAGYGEYFIHRLG 297
Query: 287 HGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKT 346
HG+G+E+HE+P ++ ++ VL+EGM +IEPGIYIP F GVRIED V+TK G + T T
Sbjct: 298 HGIGMEVHEFPSIANGNDVVLEEGMCFSIEPGIYIPGFAGVRIEDCGVLTKEGFKPFTHT 357
Query: 347 EREL 350
+EL
Sbjct: 358 SKEL 361
>pir||F65012 hypothetical protein b2385 - Escherichia coli (strain K-12)
>gi|1788728|gb|AAC75444.1| (AE000326) putative peptidase
[Escherichia coli K12]
Length = 361
Score = 228 bits (574), Expect = 1e-58
Identities = 128/344 (37%), Positives = 193/344 (55%), Gaps = 17/344 (4%)
Query: 13 EFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEY-EMAKEESKIP 71
+++ +DAVL++ N G S GY++++ + A + V Y E+
Sbjct: 9 DWLKAQQLDAVLLSSRQNKQPHLGIST-GSGYVVISRESAHILVDSRYYVEVEARAQGYQ 67
Query: 72 VEKFKRRDDFYKVF------EGVKVLGIEGS-LSYSFVEDLKEKGKISEFKKVDDVIKEM 124
+ + + E ++ LG EG +S+ + + DV+++
Sbjct: 68 LHLLDATNTLTTIVNQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQ- 126
Query: 125 RIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTI 184
+K+ EE++ I AC IAD+ + G EREIAA++E+ M+ GAEK +FDTI
Sbjct: 127 --IKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTI 184
Query: 185 IASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQRE----- 239
+ASG+R ALPHG ASDK + G+ V +D GALY Y SD+TRT++V
Sbjct: 185 VASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHLLFN 244
Query: 240 IYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGV 299
+Y+IVL+AQ A+ A RPG+ +++D AR +I E GYGDYF H+ GH +G+E+HE P
Sbjct: 245 VYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPRF 304
Query: 300 SQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRL 343
S D T L+ GM++T+EPGIY+P GGVRIED +++T GA L
Sbjct: 305 SPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVL 348
>dbj|BAB06898.1| (AP001518) prolidase (proline dipeptidase) [Bacillus halodurans]
Length = 364
Score = 227 bits (573), Expect = 1e-58
Identities = 132/359 (36%), Positives = 200/359 (54%), Gaps = 14/359 (3%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSG----ASPLAGGYILVNNDGATLYVPELEY 61
E+IKR+IE++ +N I +I+YL+G +L L P +E
Sbjct: 2 ERIKRVIEWLKDNDHSMAFIQDKTSIFYLTGFYCDPHERLVSLLLFPEAEPCLICPNMET 61
Query: 62 EMAKEE---------SKIPVEKFKRRDDFYKVFEGVKVLGIEGS-LSYSFVEDLKEKGKI 111
+ KE S I R K + +E L+Y+ V+ L++
Sbjct: 62 SLVKEAGWTGEILGYSDIEDPWLLVRQAVEKRNAVLTSCIVEAPRLTYARVQALQDAFPA 121
Query: 112 SEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM 171
+ + + E+R KS +E+ +++A +AD V ++ + EG+ E EI A +EY +
Sbjct: 122 IKLIDGEPFLMELRKQKSAKELTTLKEAAALADYGVEVGVQAIQEGRSEIEILALIEYEL 181
Query: 172 KMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVG 231
K G +F T++ SG +SA PHG + I+KGD V+ DLG + + Y SDITRTV
Sbjct: 182 KRKGVRDMSFGTLVLSGDQSANPHGNPGQRTIKKGDFVLFDLGVVLDGYCSDITRTVAFH 241
Query: 232 SPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGL 291
++Q++IYE V +AQ+ A++A RPG+ + LD IAR II E GYGDYF H +GHG+G+
Sbjct: 242 HVTDQQQDIYETVRKAQQAALDACRPGVEIRTLDQIARTIITEAGYGDYFPHRIGHGLGM 301
Query: 292 EIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTEREL 350
E+HE P +++ + L++GMV TIEPGIY+P GGVRIED +VIT+ G + LT + L
Sbjct: 302 EVHELPSLNETNTDRLQKGMVFTIEPGIYLPSIGGVRIEDDVVITEDGYQTLTNYPKNL 360
>sp|O84913|PEPQ_LACHE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE)
>gi|3282339|gb|AAC24966.1| (AF012084) prolidase
[Lactobacillus helveticus]
Length = 368
Score = 222 bits (560), Expect = 5e-57
Identities = 109/235 (46%), Positives = 161/235 (68%), Gaps = 1/235 (0%)
Query: 117 VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN-G 175
V I+ +R+ K+ EEIK ++ A AD A + + G ER IA +++Y +K+ G
Sbjct: 127 VSSFIERLRLYKTPEEIKKLQGAGAEADFAFKIGFDAIRTGVTERSIAGQIDYQLKIQKG 186
Query: 176 AEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNE 235
+F+TI+ +G +A PH + ++ +LV+ DLG +++ Y SD +RTV G+P++
Sbjct: 187 VMHESFETIVQAGKNAANPHLGPTMNTVQPNELVLFDLGTMHDGYASDSSRTVAYGTPSD 246
Query: 236 KQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHE 295
KQREIYE+ EAQ+ A+EAA+PGIT +ELDS+AR+II + GYG+YFIH LGHG+G +HE
Sbjct: 247 KQREIYEVDREAQQAAIEAAKPGITAEELDSVARDIITKAGYGEYFIHRLGHGIGKNVHE 306
Query: 296 WPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTEREL 350
+P + Q ++ VL+EGM +IEPGIYIP F GVRIED V+TK G + T T+++L
Sbjct: 307 YPSIVQGNDLVLEEGMCFSIEPGIYIPGFAGVRIEDCGVVTKDGFKTFTHTDKDL 361
>dbj|BAA16255.1| (D90868) PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INTERGENIC REGION (EC
3.4.-.-). [Escherichia coli]
Length = 262
Score = 221 bits (557), Expect = 1e-56
Identities = 108/225 (48%), Positives = 149/225 (66%), Gaps = 5/225 (2%)
Query: 124 MRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDT 183
+R +K+ EE++ I AC IAD+ + G EREIAA++E+ M+ GAEK +FDT
Sbjct: 25 LRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDT 84
Query: 184 IIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQRE---- 239
I+ASG+R ALPHG ASDK + G+ V +D GALY Y SD+TRT++V
Sbjct: 85 IVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHLLF 144
Query: 240 -IYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPG 298
+Y+IVL+AQ A+ A RPG+ +++D AR +I E GYGDYF H+ GH +G+E+HE P
Sbjct: 145 NVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPR 204
Query: 299 VSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRL 343
S D T L+ GM++T+EPGIY+P GGVRIED +++T GA L
Sbjct: 205 FSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVL 249
>gb|AAC46293.1| (AF014460) PepQ [Streptococcus mutans]
Length = 359
Score = 220 bits (555), Expect = 2e-56
Identities = 126/359 (35%), Positives = 215/359 (59%), Gaps = 18/359 (5%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSG--ASP---LAGGYILVNNDGATLYVPELEY 61
K+ +I++ + + I+A +++ +I YL+G + P L ++ + + L++PEL+
Sbjct: 3 KLAQIVQKLKKQGIEAAVLSDPVSINYLTGFYSDPHERLMFLFLFADQE-TLLFLPELDA 61
Query: 62 EMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGS-----LSYSFVEDLKEKGKIS---- 112
AK I V + DF E +K L + + L + + K KG +
Sbjct: 62 LRAKSILDISVTGYL---DFENPLEKIKTLLPKTNYSKIALEFDNLNVTKFKGLETIFSG 118
Query: 113 EFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMK 172
+F + +I MR++KS +EI+ + A E+ADKAV + ++ E +I A++E+ MK
Sbjct: 119 QFTNLTPLINRMRLIKSADEIQKLLIAGELADKAVQIGFDSISLNATETDIIAQIEFEMK 178
Query: 173 MNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGS 232
G +K +F+T++ +G +A PHG+ + +IE L++ DLG Y SD+TRTV VG
Sbjct: 179 KLGVDKMSFETMVLTGSNAANPHGLPASHKIENNHLLLFDLGVESTGYVSDMTRTVAVGQ 238
Query: 233 PNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLE 292
P++ +++IY I LEAQ A++ +PG++ ++D+ AR++I++ GYGDYF H LGHG+G+
Sbjct: 239 PDQFKKDIYNICLEAQLTALDFIKPGVSAAQVDAAARSVIEKAGYGDYFNHRLGHGIGMG 298
Query: 293 IHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
+HE+P + ++ +L+EGM ++EPGIYIP+ GVRIED +TK G T+T +EL+
Sbjct: 299 LHEFPSIMAGNDMLLEEGMCFSVEPGIYIPEKVGVRIEDCGHVTKNGFEVFTQTPKELL 357
>gb|AAK40693.1| Prolidase (Xaa-Pro dipeptidase) (pepQ) [Sulfolobus solfataricus]
Length = 352
Score = 217 bits (547), Expect = 2e-55
Identities = 129/341 (37%), Positives = 196/341 (56%), Gaps = 17/341 (4%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKE 66
K+K I+E ++ +I +PN++Y S G ++ + TL VP LE A+
Sbjct: 6 KLKAILEDKKDS---CAIIFGSPNLFYFLEYS--GAGALIYCDSRFTLLVPALEMYRAEN 60
Query: 67 ESKIPVEKFKRRDDFYKVFEGVKVLGIEG-------SLSYSFVEDLKEKGKISEFKKVD- 118
+ + + V EG IE L S+VE K ++K +D
Sbjct: 61 VKDVDIAIYYPSKILENVIEGNIFRAIEKIVNKSNIMLDVSWVEASTYKALSEKYKVIDF 120
Query: 119 -DVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEG-KKEREIAAKVEYLMKMNGA 176
+ I +R VK ++EI+ I KA EI A+ +E+++EG E+++A ++ M+ GA
Sbjct: 121 SNEIVRLREVKDNDEIERIRKAGEITAVAMKIGMEKLSEGTSNEKQVAGIIDMTMRSMGA 180
Query: 177 EKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
E AF +I+A G SA PH + +D+ + D+V+ D+GA YN Y D TRT V N +
Sbjct: 181 EDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVF--KNSE 238
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEW 296
+++YE+VLEAQ +A++A R G+ E+D AR +I++ GYG YFIHS GHGVG+EIHE
Sbjct: 239 AKKVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIHES 298
Query: 297 PGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITK 337
P VS + +LKE M+IT+EPGIY+ G+RIEDT+++TK
Sbjct: 299 PAVSMNSKQILKENMIITVEPGIYLKGRFGIRIEDTLIVTK 339
>gb|AAD53120.1|AF176799_2 (AF176799) PepQ [Lactobacillus pentosus]
Length = 369
Score = 211 bits (532), Expect = 9e-54
Identities = 122/359 (33%), Positives = 202/359 (55%), Gaps = 15/359 (4%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSG--ASPLAG--GYILVNNDGATLYVPELEYE 62
K++++ ++ +N +D I+ I YL+G ++P G + + L+ P LE E
Sbjct: 6 KLQQVRQWTQDNHVDVTYISNFHTISYLTGFESNPYERTLGLFVFADAEPFLFAPALEVE 65
Query: 63 MAKEES-KIPVEKFKRRDDFYKVFE--------GVKVLGIE-GSLSYSFVEDLKEKGKIS 112
KE V + +D Y + K +E G+L+ LK + +
Sbjct: 66 AIKEMGWPYKVFGYLDHEDPYALIATHIQEQLTDPKSWALEAGNLTLDRFNALKAQFPAA 125
Query: 113 EFKK-VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM 171
F K + I+++R+VK+ +E++ + A + AD A V G+ E++IAA+++Y +
Sbjct: 126 HFDKDLSPYIQQLRLVKTADELEKLNIAGKWADFAFEQGFAAVKAGRTEQQIAAELQYAL 185
Query: 172 KMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVG 231
G + +FDT++ +G +A PHG ++ +++ +LV+ DLG +Y Y SD +RT+ G
Sbjct: 186 MKKGIMEMSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASRTIAYG 245
Query: 232 SPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGL 291
P +KQ+EI+++ LEA A A +PG+ +++D IAR+II + GYG+YFIH LGHG+G
Sbjct: 246 QPTDKQKEIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLGHGIGQ 305
Query: 292 EIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTEREL 350
HE+P + + L EGM ++EPGIYIP GVRIED V+TK G + T T +E+
Sbjct: 306 TDHEFPSIMAGNHMPLVEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHTPKEM 364
>pir||C70658 probable pepQ - Mycobacterium tuberculosis (strain H37RV)
>gi|1781067|emb|CAB06173.1| (Z83863) pepQ [Mycobacterium
tuberculosis]
Length = 372
Score = 201 bits (505), Expect = 1e-50
Identities = 120/330 (36%), Positives = 189/330 (56%), Gaps = 14/330 (4%)
Query: 18 NSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKEES----KIPVE 73
+ +DA+LI+ N+ YLSG S G ++ ++ + + Y ++ +E
Sbjct: 17 SGLDAMLISDLINVRYLSGFSGSNGALLVFADERDAVLATDGRYRTQAASQAPDLEVAIE 76
Query: 74 KFKRRDDFYKVFE-GVKVLGIEGSLSYSFVEDLKE-----KGKISEFKKVDDVIKEMRIV 127
+ R + E GV LG E + V+ L +GK +E + ++ +R V
Sbjct: 77 RAVGRYLAGRAGEAGVGKLGFESHVVT--VDGLDALAGALEGKNTELVRASGTVESLREV 134
Query: 128 KSDEEIKIIEKACEIADKAV--MAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTII 185
K E+ ++ ACE AD A+ + A + G+ ER+++ ++E LM +GA+ +F+TI+
Sbjct: 135 KDAGELALLRLACEAADAALTDLVARGGLRPGRTERQVSRELEALMLDHGADAVSFETIV 194
Query: 186 ASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVL 245
A+G SA+PH +D ++ GD V ID GAL Y+SD+TRT V+G + Q EIY++V
Sbjct: 195 AAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYHSDMTRTFVLGKAADWQLEIYQLVA 254
Query: 246 EAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYDET 305
EAQ+ +A PG + +D+ AR +I + GYG++F H LGHGVGL+IHE PG+
Sbjct: 255 EAQQAGRQALLPGAELRGVDAAARQLIADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAG 314
Query: 306 VLKEGMVITIEPGIYIPKFGGVRIEDTIVI 335
L G V+T+EPG+Y+P GGVRIEDT+V+
Sbjct: 315 TLLAGSVVTVEPGVYLPGRGGVRIEDTLVV 344
>pir||C70433 probable X-Pro dipeptidase (EC 3.4.13.9) - Aquifex aeolicus
>gi|2983896|gb|AAC07447.1| (AE000744) xaa-pro
dipeptidase [Aquifex aeolicus]
Length = 354
Score = 198 bits (497), Expect = 1e-49
Identities = 120/355 (33%), Positives = 197/355 (54%), Gaps = 14/355 (3%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKE 66
K+K + E + E ++DA + + PN++YLS Y ++ L YE AK
Sbjct: 2 KVKEVQELIKEKNLDAFMFSSQPNVFYLSRFRS-TNAYAVITPQEKYLLTDARYYERAKN 60
Query: 67 ESK------IPVEKFKRRDDFYKVFEGVKVLGIEGS-LSYSFVEDLKEKGKISEFKKVDD 119
+ K I FK +F + +G+K +G E +S +F + LK K + +
Sbjct: 61 QLKDWEVVLIKGNLFKSVKNFLRE-KGLKYVGYEEDRVSCTFKKHLKSKH--IRWVGFSN 117
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
+K +R++K+ EEI I+++ +DK + V G E ++ + + E
Sbjct: 118 FLKNVRVLKTKEEISIMKEGVRKSDKIYRELLNFVKPGMTELQVRGFIVSKIFEKNGEGE 177
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQRE 239
+F I+ASG SA+PH +S ++I++ ++ID+G L+ Y +D TRT +G P+E+ R+
Sbjct: 178 SFPAIVASGEHSAVPHWESSREKIKENAPLLIDMGLLWEGYCTDFTRTFHIGKPSEEFRK 237
Query: 240 IYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGV 299
+YEIV EA +A+E A+ G T ++D AR I++ GYG +F HS GHGVG+EIHE+P V
Sbjct: 238 VYEIVKEAHLRALEKAKVGNTVGDVDRAAREYIEKKGYGQFFTHSTGHGVGVEIHEFPRV 297
Query: 300 ---SQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
+T ++EGMV TIEPGIY+P GVR+E+ + + + L++ + EL+
Sbjct: 298 YYKGDDAKTPIEEGMVFTIEPGIYLPGKFGVRLENIVAVQGGVGKPLSEIDLELV 352
>gb|AAK40375.1| X-pro aminopeptidase [Sulfolobus solfataricus]
Length = 351
Score = 195 bits (490), Expect = 7e-49
Identities = 116/354 (32%), Positives = 197/354 (54%), Gaps = 18/354 (5%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGAS------PLAGGYILVNNDGATLYVPELE 60
+I+R+ + + + D ++ N+YYL G S PL + + D L VP+L
Sbjct: 3 RIQRVQKELERANADYLITGTTSNMYYLIGFSEEQMERPLL---LFITRDDYFLLVPKLY 59
Query: 61 YEMAKEESKIPVEKFKRRDDFYKVF---EGVKVLGIEGSLSYSFVEDLKEKGKISEFKKV 117
E K+ P+ ++ +D Y E VL I+ + F ++ + K +
Sbjct: 60 EEQLKQ---FPLIVYRDGEDPYSKLNLKENSNVL-IDDTTFSLFTIEILNRFKPGRIGRA 115
Query: 118 DDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAE 177
++ ++R VK DEE++ +EK + A++ ++ + + E E +I K++ + + A
Sbjct: 116 SRILGKLRQVKDDEELEKMEKGVKKAEQLILEFVSNIKENMTECQIERKLKSFL-IEEAG 174
Query: 178 KPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQ 237
+FD I+ SG S++PH SDK++++G+ +VID G ++ Y++D TR +G PN+
Sbjct: 175 NISFDPIVTSGPNSSMPHLRCSDKKVKRGEAIVIDYGIKHDGYSTDTTRVFSLGKPNDPL 234
Query: 238 -REIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEW 296
EI EIV A ++A + R G+ KE+D AR +I GYGDYFIH GHG+G+++HE
Sbjct: 235 ILEIVEIVKTANEEAEKHVREGMRAKEIDYFAREVITNKGYGDYFIHRTGHGIGIDVHED 294
Query: 297 PGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTEREL 350
P +S ++ V+++ MV TIEPGIY+P G+RIED +V+ K + L ++EL
Sbjct: 295 PYISPDNDDVIEQNMVFTIEPGIYLPGKFGIRIEDEVVVKKGYGKTLNMLQKEL 348
>pir||B72032 proline dipeptidase CP1058 [imported] - Chlamydophila pneumoniae
(strains CWL029 and AR39) >gi|4377125|gb|AAD18951.1|
(AE001662) Aminopeptidase P [Chlamydophila pneumoniae
CWL029] >gi|7189972|gb|AAF38831.1| (AE002263) proline
dipeptidase [Chlamydophila pneumoniae AR39]
>gi|8979187|dbj|BAA99021.1| (AP002548) aminopeptidase P
[Chlamydophila pneumoniae J138]
Length = 355
Score = 195 bits (490), Expect = 7e-49
Identities = 107/344 (31%), Positives = 194/344 (56%), Gaps = 8/344 (2%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAK 65
++I R ++E+++DA+L+ K+ ++ Y +AG +L+ +V ++ ++
Sbjct: 4 DRILRAQRALSEHNLDAILVEKSEDLAYFLHDEAIAG-ILLIGQQEVMFFVYRMDKDLYS 62
Query: 66 EESKIPVEKFKRRD-----DFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEFKKVDDV 120
++P+ F +D Y + + +G + S S + + + + ++ ++
Sbjct: 63 HIQRVPLT-FLTQDVVADLSLYVQKQRYQKIGFD-SASTVYHKFAQRQVLPCLWEPLECF 120
Query: 121 IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA 180
+++R +KS+EEI+ +++A + + + EG E+E+ ++ GAE P+
Sbjct: 121 TEKIRSIKSEEEIRRMQEAAALGSAGYDYVLTLLREGITEKEVVRQLRAFWAEAGAEGPS 180
Query: 181 FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI 240
F IIA G SA PH + +D+ ++KGD+V+ID+G L N Y SD+TR +G+P+ K E
Sbjct: 181 FPPIIAFGEHSAFPHSIPTDRPLKKGDIVLIDIGVLLNGYCSDMTRMTALGTPHPKLLES 240
Query: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVS 300
Y +V+EAQK+A+ + G+ ++D+ A +++E+ YFIH +GHGVG IHE+P
Sbjct: 241 YPVVVEAQKRAMALCKEGVLWGDIDAEAVRVLREHHLDTYFIHGIGHGVGRHIHEYPCSP 300
Query: 301 QYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLT 344
+ + L+ GM IT+EPG+Y P GG+RIEDT+ I K LT
Sbjct: 301 RGSQVKLESGMTITVEPGVYFPGIGGIRIEDTLCIDKNKNFSLT 344
>pir||A72750 probable Xaa-Pro dipeptidase APE0526 - Aeropyrum pernix (strain
K1) >gi|5104177|dbj|BAA79493.1| (AP000059) 349aa long
hypothetical Xaa-Pro dipeptidase [Aeropyrum pernix]
Length = 349
Score = 194 bits (489), Expect = 1e-48
Identities = 127/357 (35%), Positives = 183/357 (50%), Gaps = 38/357 (10%)
Query: 24 LITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKEESKIPVEKFKRRDDFYK 83
+I N+ Y G AG +L G+TL VP L+YE A VE FY+
Sbjct: 1 MIAGEANLVYALGYGNPAGVLVLSGKCGSTLVVPLLDYERALRSVDTDVEV----KAFYR 56
Query: 84 VFEGVKVLGIEGSLSYSFV---EDLKEKGK---------ISEFKKV-------------- 117
E GIE + S + E++ E K +FK +
Sbjct: 57 GGES----GIEPDIPKSDLISSENMAEAAKRVLEGCSSPAVDFKWLRWETATALSNALDN 112
Query: 118 ----DDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKM 173
+I ++R VK + EI +I +A IA+ A+ IEE+ EG ERE+A V ++
Sbjct: 113 PGDGSQLISQVRSVKEEWEIGLIAEAARIAEAALRRGIEELREGVSEREVAGAVVDVIMK 172
Query: 174 NGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSP 233
+G P+F I+A G +ALPH D R+ V+ DLG++Y Y SD+TR++ G
Sbjct: 173 SGGWGPSFPVIVAFGGNTALPHHHTGDARLPHASPVLFDLGSVYKGYMSDMTRSLWRGPG 232
Query: 234 NEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEI 293
+ R + E+V EAQ +A+++ PG+ E+D AR + + G+ YFIH GHGVG+EI
Sbjct: 233 GAEYRRLEELVAEAQAEAIDSVAPGVEAWEVDKAARLRLSKEGFSKYFIHGTGHGVGVEI 292
Query: 294 HEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTEREL 350
HE P + LK GMV+TIEPG+Y+P GVRIED +++TK G + LT R L
Sbjct: 293 HENPYLRPGSSEELKPGMVVTIEPGVYLPGMYGVRIEDMVLVTKRGRKLLTSFARIL 349
>sp|P75313|AMPP_MYCPN PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE)
(AMINOPEPTIDASE P) (APP) (AMINOACYLPROLINE
AMINOPEPTIDASE) >gi|2146699|pir||S73697 probable X-Pro
dipeptidase (EC 3.4.13.9) pepX - Mycoplasma pneumoniae
(strain ATCC 29342) >gi|1674050|gb|AAB96019.1|
(AE000035) X-Pro dipeptidase [Mycoplasma pneumoniae]
Length = 354
Score = 193 bits (485), Expect = 3e-48
Identities = 123/341 (36%), Positives = 186/341 (54%), Gaps = 12/341 (3%)
Query: 2 NIMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEY 61
N + +K+ + + + +N DA+LI + N ++L+G P + G+++V+ L++ +
Sbjct: 3 NELQQKLAVLHKLLQDNKADAILIGSDQNRFWLTGF-PSSAGWLVVHKQRVNLFIDGRYF 61
Query: 62 EMAKE--ESKIPVEKFKRRDDFYKVFE--GVKVLGIEGS-LSYSFVEDLKEKGKISEFKK 116
E AK + + VE F + E GVK L IEG L++++ +KE +++
Sbjct: 62 EAAKTAIDPLVKVELFTTYKQVKALCEQVGVKHLLIEGDYLTFNYQNFIKEL--CAQYTV 119
Query: 117 VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA 176
++ +E+R K EI IEK EI K + + G E IA + + G
Sbjct: 120 IN--AQEIRRQKLPSEILAIEKVVEITRKVAVKLKRFIQPGMTELFIAQWITDQLVKAGG 177
Query: 177 EKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSP--N 234
K +FD I+A+G A PH S +++ GD V D G +YN Y SDITRT +VG N
Sbjct: 178 AKNSFDPIVATGKNGANPHHKPSKLKVKSGDFVTCDFGTIYNGYCSDITRTFLVGKKPNN 237
Query: 235 EKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIH 294
E + Y+ V EA + AA +T E+D + R+II+ + DYF+HS GHGVGL+IH
Sbjct: 238 EVLLKAYKKVDEANMAGINAANTQLTGAEVDKVCRDIIEASEFKDYFVHSTGHGVGLDIH 297
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVI 335
E P VS +L E VITIEPGIYIP GG+RIED +++
Sbjct: 298 EMPNVSTSYNKLLCENAVITIEPGIYIPSVGGIRIEDMVLV 338
>pir||H71496 probable aminopeptidase P - Chlamydia trachomatis (serotype D,
strain UW3/Cx) >gi|3329016|gb|AAC68176.1| (AE001328)
Aminopeptidase P [Chlamydia trachomatis]
Length = 356
Score = 192 bits (484), Expect = 4e-48
Identities = 117/352 (33%), Positives = 186/352 (52%), Gaps = 11/352 (3%)
Query: 8 IKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKEE 67
IKR+ + + E ++DA LI K+ +I Y G +L+ D A L+V L+ ++
Sbjct: 6 IKRLQDSLVERALDAFLIEKDEDISYFL-QDQARSGVLLITRDEAVLFVSPLDKDLYARI 64
Query: 68 SKIPVEKFKRRDD----FYKVFEGVKVLGIEGSLS-YSFVEDLKEKGKISEFKKVDDVIK 122
+ + + + D Y G+K +G + + Y + G F V +
Sbjct: 65 QDVVLVSYSKSVDQELGSYIENTGLKTIGFDSEYTPYGIAQKRMNSGYA--FSPQSLVAE 122
Query: 123 EMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFD 182
++R VKS EEI+ + +A EI + + G E+E+ + G EK +F
Sbjct: 123 KLRCVKSTEEIQKMTRAAEIGSAGYDFVLAALRPGITEKELVRMLHVFWANLGIEKVSFP 182
Query: 183 TIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQR-EIY 241
IIA G +A PH + +++ ++KGD+V+ID+G Y Y SD+TRTV G+ E+Q + Y
Sbjct: 183 PIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGATPEQQLLDGY 242
Query: 242 EIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQ 301
V EAQ+ A+E R G+ +++ A I++ +G FIH LGHGVG E+HE+P +S
Sbjct: 243 VAVAEAQRAAIEFCRAGVPCRDVHKEAVRILRAHGMEKAFIHGLGHGVGREVHEYPRLSP 302
Query: 302 YDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLT--KTERELI 351
+ + L+ M +T+EPG+Y P GG+RIEDTI+I LT K E+I
Sbjct: 303 FSDATLQLNMAVTVEPGVYFPGVGGIRIEDTIMIGVNENLNLTNRKVSSEII 354
>emb|CAB07979.1| (Z93945) prolidase-related protein [Lactobacillus delbrueckii]
Length = 373
Score = 191 bits (481), Expect = 8e-48
Identities = 121/365 (33%), Positives = 196/365 (53%), Gaps = 21/365 (5%)
Query: 5 DEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYI---LVNNDG-ATLYVPELE 60
+E + + +++E ID + + +I YL+G S + LV+ G A L P +
Sbjct: 10 EEHLAALTSYLDEKGIDLAYVAEPVDIAYLTGYSSWTEERVFALLVSRTGQALLLAPAIN 69
Query: 61 YEMAKEES-----------KIPVEKFKRRDDFY-KVFEGVKVLGIEGSLSYSFVEDLKEK 108
K+ S + P EK K+R + K F ++ + S + E E
Sbjct: 70 EGEVKQTSWADRACFYQDGENPWEKAKKRMTAWPKGFWALEARAVTLSHYRAIKEVFPEA 129
Query: 109 GKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAV--MAAIEEVTEGKKEREIAAK 166
S+ + + R++KS EI+ ++ A +AD+A+ A+ + +G E E+A +
Sbjct: 130 NLASD---ISTWLARQRMIKSPAEIEKLQAAGRLADQALDLAFALLKAGQGMSESELALE 186
Query: 167 VEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITR 226
++Y +K G +F I+ +G +A G+ S K ++ GD+V+ DLG + + Y SD++R
Sbjct: 187 LDYQLKKKGMGDLSFPLIVQAGESAASISGLPSQKGVQAGDIVIFDLGIMKDGYASDVSR 246
Query: 227 TVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLG 286
TV +G + + EIYE V AQ+ A AARPG+T ELD +AR +I+E GYG YF H LG
Sbjct: 247 TVALGEISPAKWEIYETVRLAQETAARAARPGMTAGELDQVARGVIEEAGYGQYFTHRLG 306
Query: 287 HGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKT 346
HG+G+++HE + + L+ GM +IEPGIY+P GGVRIED + + G TKT
Sbjct: 307 HGIGMQVHEPVNLEPGSKQKLEAGMCFSIEPGIYLPGVGGVRIEDCGWLGEDGFHPFTKT 366
Query: 347 ERELI 351
++L+
Sbjct: 367 RKDLL 371
>pir||T35868 probable dipeptidase - Streptomyces coelicolor
>gi|4691402|emb|CAB41569.1| (AL049727) putative
dipeptidase [Streptomyces coelicolor A3(2)]
Length = 376
Score = 189 bits (475), Expect = 4e-47
Identities = 115/362 (31%), Positives = 192/362 (52%), Gaps = 23/362 (6%)
Query: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGG-----YILVNNDGATLYVPELEY 61
+++R + + +L+ P++ +L+G +P A +L + L VP LE
Sbjct: 18 RMERAARAAADAGLAGLLVAPGPDLVWLTGYAPTADTERLTLLVLAPDRDPVLVVPTLEA 77
Query: 62 EMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVED--------LKEKGKISE 113
A + + P + D + L ++GS + ++ L+ +
Sbjct: 78 PDAAKAAGAPALTLRDWTDGKDPYAATAAL-LDGSGRFGISDNAWAMHLLALQRTLPDTS 136
Query: 114 FKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTE----GKKEREIAAKVEY 169
+ + + + +R VK E++++ A AD AA EE+ G++E E+AA +
Sbjct: 137 YASLTEALPMLRAVKDAAELELLAAAGAAAD----AAFEEIRRVRFGGRRESEVAADLAD 192
Query: 170 LMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVV 229
L++ G + F TI+ASG A PH D+ IE GD++V+D G L + Y SD +RTV
Sbjct: 193 LLRRFGHSQVDF-TIVASGPNGANPHHEVGDRVIEDGDMIVLDFGGLKDGYGSDTSRTVH 251
Query: 230 VGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGV 289
VG+P +++R ++++V EAQ+ A RPG +++D AR +I GYG+YFIH GHG+
Sbjct: 252 VGAPTDEERRVHDLVREAQEAGFCAVRPGAACQDVDRAARAVIAGAGYGEYFIHRTGHGI 311
Query: 290 GLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERE 349
G+ HE P + + +E L GM ++EPG+Y+P GVRIED + +T+ G RRL T RE
Sbjct: 312 GVTTHEPPYMIEGEEQPLVPGMCFSVEPGVYLPGRFGVRIEDIVTVTEDGGRRLNDTTRE 371
Query: 350 LI 351
++
Sbjct: 372 MV 373
>pir||F81657 proline dipeptidase TC0863 [imported] - Chlamydia muridarum
(strain Nigg) >gi|7190889|gb|AAF39659.1| (AE002352)
proline dipeptidase [Chlamydia muridarum]
Length = 356
Score = 185 bits (464), Expect = 8e-46
Identities = 109/334 (32%), Positives = 180/334 (53%), Gaps = 9/334 (2%)
Query: 8 IKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKEE 67
I R+ ++ ++DA LI K+ +I Y +G +LV++D +V L+ ++
Sbjct: 6 ITRLQHLLSGYALDAFLIEKDEDISYFLQDQAKSGA-LLVSSDEVVFFVSPLDRDLYAHI 64
Query: 68 SKIPVEKFKRRDD----FYKVFEGVKVLGIEGSL-SYSFVEDLKEKGKISEFKKVDDVIK 122
+ + + D Y +G+K +G + SY + G F V +
Sbjct: 65 QDVSLVFCSKNIDQHLFAYIEEKGLKTIGFDSEYTSYGTAQKRMRSGLT--FSPQSLVTE 122
Query: 123 EMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFD 182
++R VKS EI+ + +A EI + + G E+E+ + G EK +F
Sbjct: 123 KLRCVKSPNEIQKMMRAAEIGSAGYDFVLAALRPGITEKELVRLLHVFWANLGIEKLSFP 182
Query: 183 TIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVG-SPNEKQREIY 241
IIA G +A PH + +++ ++KGD+V+ID+G Y Y SD+TRTV G +P ++ + Y
Sbjct: 183 PIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGEAPEQQLLDGY 242
Query: 242 EIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQ 301
V EAQ++++E R G++ + + A +++EYG FIH LGHGVG E+HE+P +S
Sbjct: 243 LAVAEAQRRSIELCREGVSCRAVHEEAVRVLREYGMEKAFIHGLGHGVGREVHEYPRLSL 302
Query: 302 YDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVI 335
+ + L+ M +T+EPG+Y P GG+RIEDTIVI
Sbjct: 303 FSDAELQLNMAVTVEPGVYFPGVGGIRIEDTIVI 336
>pir||F82878 XAA-PRO aminopeptidase UU532 [imported] - Ureaplasma urealyticum
>gi|6899536|gb|AAF30945.1|AE002152_4 (AE002152) XAA-PRO
aminopeptidase [Ureaplasma urealyticum]
Length = 357
Score = 183 bits (461), Expect = 2e-45
Identities = 118/353 (33%), Positives = 187/353 (52%), Gaps = 14/353 (3%)
Query: 5 DEKIKRIIEFMNENSI---DAVLITKNPNIY-YLSGASPLAGGYILVNNDGATLYVPELE 60
D K++++++ + E+ D +++ N N Y +L AS + G++ +N DG +Y+ +
Sbjct: 3 DFKLQQVLKTIKEHEAQGADGMILFSNYNRYWFLEFAS--SDGFVFINKDGKAIYLVDAR 60
Query: 61 YEMAKEES-KIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVE------DLKEKGKISE 113
Y A E+ K R F+ +K +E +++ + VE D+ E K
Sbjct: 61 YYTAASETVKNAKVILLARTPQKSTFDLLKDAMVELNITNALVEADYVTLDVHEMLKKLV 120
Query: 114 FKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKM 173
+R +K+++E++ ++KA +IA E+ G+ E EIA V M
Sbjct: 121 KNTTPFTSATLRAIKTEKELEYLQKAADIAALTCNWIREQDIIGRTELEIATLVSKHMLE 180
Query: 174 NGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSP 233
G E +FD IIASG PH ++ IE GD+V +D+G Y Y SDITR+ +VG+
Sbjct: 181 LGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNK 240
Query: 234 -NEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLE 292
N + +EIY+ VLE+Q + +T +E+D + R+I+ + YF H GHGVGL+
Sbjct: 241 ANPQMQEIYDKVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQ 300
Query: 293 IHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTK 345
+HE P + + L V+T+EPGIYIP GGVRIEDTIV+ A LT+
Sbjct: 301 VHELPNTNAGNPNKLPLNAVVTVEPGIYIPNVGGVRIEDTIVVKDGQALVLTR 353
>sp|P47566|AMPP_MYCGE PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE)
(AMINOPEPTIDASE P) (APP) (AMINOACYLPROLINE
AMINOPEPTIDASE) >gi|1361898|pir||H64235 X-Pro
aminopeptidase (EC 3.4.11.9) - Mycoplasma genitalium
>gi|3844901|gb|AAC71546.1| (U39713) aminopeptidase P
(pepP) [Mycoplasma genitalium]
Length = 354
Score = 180 bits (453), Expect = 2e-44
Identities = 115/351 (32%), Positives = 191/351 (53%), Gaps = 14/351 (3%)
Query: 4 MDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEM 63
+ +KI + + + N DA+LI + N ++L+ P + G++++ ++ A L++ YE
Sbjct: 5 LQQKITVLKDLLKTNKADAILIGSDQNRFWLTNF-PSSAGWLIITSNKAKLFIDGRYYEA 63
Query: 64 AKEESKIPVE-----KFKRRDDFYKVFEGVKVLGIEGS-LSYSFVEDLKEKGKISEFKKV 117
A+ VE FK+ F + G+ L IEG L++++ + ++ K ++ +
Sbjct: 64 ARNFINPIVEVELFVSFKQVKAFCES-NGINHLLIEGDYLTFNYQDWIQAICK--QYTVI 120
Query: 118 DDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAE 177
+ +E+R VK EI+ IEKA +I K + + E I+ + + G
Sbjct: 121 N--AQEIRRVKLPSEIQAIEKAVDITRKVAVKLKRFIKPKMTELFISQWITNELVKQGGA 178
Query: 178 KPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSP--NE 235
K +FD I+A+G A PH + +++GD + D G +YN Y SDITRT +VG +
Sbjct: 179 KNSFDPIVATGKNGANPHHKPTKTIVKEGDFITCDFGTIYNGYCSDITRTFLVGKKPKSA 238
Query: 236 KQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHE 295
K Y+ V EA + A +T ++D + R+II+ + D+F+HS GHGVG++IHE
Sbjct: 239 KLLSAYKKVEEANLAGINAVNTTLTGSQVDKVCRDIIENSEFKDFFVHSTGHGVGIDIHE 298
Query: 296 WPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKT 346
P VSQ +L E V+TIEPGIYIP GG+RIED +++ K + L+K+
Sbjct: 299 MPNVSQSYNKLLCENGVVTIEPGIYIPNLGGIRIEDMVLVKKEKSVWLSKS 349
>sp|Q10698|YK89_MYCTU PROBABLE DIPEPTIDASE RV2089C >gi|7445465|pir||D70767 probable pepQ
- Mycobacterium tuberculosis (strain H37RV)
>gi|1370256|emb|CAA98201.1| (Z73966) pepE [Mycobacterium
tuberculosis]
Length = 375
Score = 175 bits (438), Expect = 9e-43
Identities = 89/234 (38%), Positives = 138/234 (58%), Gaps = 2/234 (0%)
Query: 119 DVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEK 178
DV++ +R+VK + EI + KA D+ E + G+ E ++AA + + G +
Sbjct: 138 DVLRRLRMVKEETEIDALRKAGAAIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGHSE 197
Query: 179 PAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNH-YNSDITRTVVVGSPNEKQ 237
AF I+ SG A PH SD+ + +GD+VV+D+G Y Y+SD TRT +G P+
Sbjct: 198 VAF-VIVGSGPHGADPHHGYSDRELREGDIVVVDIGGTYGPGYHSDSTRTYSIGEPDSDV 256
Query: 238 REIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWP 297
+ Y ++ AQ+ A EA RPG+T +++D+ AR+++ E G +YF+H GHG+GL +HE P
Sbjct: 257 AQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAEAGLAEYFVHRTGHGIGLCVHEEP 316
Query: 298 GVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
+ ++ VL GM +IEPGIY P G RIED +++T+ GA + ELI
Sbjct: 317 YIVAGNDLVLVPGMAFSIEPGIYFPGRWGARIEDIVIVTEDGAVSVNNCPHELI 370
>pir||A71938 probable proline peptidase - Helicobacter pylori (strain J99)
>gi|4154912|gb|AAD05960.1| (AE001473) putative proline
peptidase [Helicobacter pylori J99]
Length = 357
Score = 172 bits (431), Expect = 6e-42
Identities = 98/240 (40%), Positives = 142/240 (58%), Gaps = 18/240 (7%)
Query: 122 KEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVT------EGKKEREIAAKVEYLMKMNG 175
++ RI+K++ EI++++K+ + +A E V E ER + KV+ + G
Sbjct: 118 RQKRIIKNEHEIQLLKKSQALNVEAFENFAEYVKKIFDEKESLSERYLQHKVKDFLTKEG 177
Query: 176 AEKPAFDTIIASGYRSALPHGVASDKRIEKGD-LVVIDLGALYNHYNSDITRTVVVG--- 231
+F+ I+A ++ PH + S K K D +++D+G Y Y SD TRT
Sbjct: 178 VYDLSFEPILALNANASKPHALPSAKDFLKADHSILLDMGIKYERYCSDRTRTAFFDPKD 237
Query: 232 -------SPNEKQRE-IYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIH 283
S +K+R+ IY+IV EAQ+KA+ R G+T KE DS+AR +I +YGYG YF H
Sbjct: 238 FVFKREQSFKDKERQKIYDIVKEAQEKAISGIRAGMTGKEADSLARGVISDYGYGQYFTH 297
Query: 284 SLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRL 343
S GHG+GL+IHE P +S ET+L+EGMV ++EPGIYIP F GVRIED +VI + A L
Sbjct: 298 STGHGIGLDIHELPYISSRSETILEEGMVFSVEPGIYIPGFFGVRIEDLVVIKNSRAELL 357
>gb|AAG19202.1| (AE005016) probable peptidase; PepQ1 [Halobacterium sp. NRC-1]
Length = 369
Score = 172 bits (431), Expect = 6e-42
Identities = 112/337 (33%), Positives = 168/337 (49%), Gaps = 16/337 (4%)
Query: 28 NPNIYYLSGASPLAGGYILV---NNDGATLYVPELEYE--MAKEESKIPVEKFKRRDDFY 82
+PN+YYLSG +LV DG +V YE +A E + + D
Sbjct: 28 SPNLYYLSGFDETPSERLLVLVVPADGEPAFVAPALYETQLAAETWVDDIRTYTDSQDPS 87
Query: 83 KVFEGVKV--------LGIEGSLSYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDEEIK 134
V V L ++ ++ F + L++ + + D V+ +R+ K D E+
Sbjct: 88 AVVRAVAADRGLTDGRLLVDPTMWAQFTQLLRDTLPDATWGLADAVLGSLRVRKDDAELD 147
Query: 135 IIEKACEIADKAV--MAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTIIASGYRSA 192
+ +A AD A+ + + G E E+A + + +G +FD I SG A
Sbjct: 148 ALRRAGGAADAAMADVRGLGADAIGMTEHELADFIADRLAAHGGTGVSFDVIAGSGPNGA 207
Query: 193 LPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVV-VGSPNEKQREIYEIVLEAQKKA 251
PH + I++GD VV D G + + Y SD TRTVV G P R ++E+V +A + A
Sbjct: 208 KPHHTHDAREIQRGDPVVCDFGTVVDRYPSDQTRTVVFAGDPPAAFRTVHEVVRDAHRAA 267
Query: 252 VEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYDETVLKEGM 311
V+A PG++ +D+ AR +I + GYGD F+H GHGVGL++HE P + + L GM
Sbjct: 268 VDAVEPGVSAGAVDAAARRVIADAGYGDAFVHRTGHGVGLDVHEAPFIVADSDRKLDVGM 327
Query: 312 VITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTER 348
V +IEPG+Y P GVRIED +V+T LT T R
Sbjct: 328 VFSIEPGVYRPGEFGVRIEDLVVVTADSCEPLTDTAR 364
>pir||E64649 probable X-Pro dipeptidase (EC 3.4.13.9) - Helicobacter pylori
(strains 26695 and NCTC 11637)
>gi|2314181|gb|AAD08080.1| (AE000611) conserved
hypothetical protein [Helicobacter pylori 26695]
Length = 357
Score = 169 bits (424), Expect = 4e-41
Identities = 96/240 (40%), Positives = 142/240 (59%), Gaps = 18/240 (7%)
Query: 122 KEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVT------EGKKEREIAAKVEYLMKMNG 175
++ RI+K++ EI++++K+ + +A E V E ER + KV+ + G
Sbjct: 118 RQKRIIKNEHEIQLLKKSQALNVEAFENFAEYVKKIFDEKESLSERYLQHKVKDFLTREG 177
Query: 176 AEKPAFDTIIASGYRSALPHGVASDKRIEKGD-LVVIDLGALYNHYNSDITRTVVVG--- 231
+F+ I+A ++ PH + S K K + +++D+G Y Y SD TRT
Sbjct: 178 VYDLSFEPILALNANASKPHALPSAKDFLKAEHSILLDMGIKYERYCSDRTRTAFFDPKD 237
Query: 232 -------SPNEKQRE-IYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIH 283
S +K+R+ IY+IV EAQ+KA+ R G+T KE DS+AR +I +YGYG YF H
Sbjct: 238 FVFKREQSFKDKERQKIYDIVKEAQEKAISGIRAGMTGKEADSLARGVISDYGYGQYFTH 297
Query: 284 SLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRL 343
S GHG+GL+IHE P +S ET+L+EGMV ++EPGIYIP F GVRIED +VI + + L
Sbjct: 298 STGHGIGLDIHELPYISSRSETILEEGMVFSVEPGIYIPGFFGVRIEDLVVIKNSRSELL 357
>emb|CAC10315.1| (AL442629) putative peptidase [Streptomyces coelicolor]
Length = 375
Score = 169 bits (423), Expect = 5e-41
Identities = 111/342 (32%), Positives = 176/342 (51%), Gaps = 17/342 (4%)
Query: 23 VLITKNPNIYYLSGASPLAGG-----YILVNNDGATLYVPELEYEMAKEE---SKIPVEK 74
VL+T P++ +L G P A +L L VP L+ A+ + V
Sbjct: 33 VLVTPGPDLVWLCGYRPTAPIERLTLLVLTATSQPRLLVPALDRPTAEASPGAGAVRVSD 92
Query: 75 FKRRDDFYKVFEGVKVLGIEGSLSYS------FVEDLKEKGKISEFKKVDDVIKEMRIVK 128
+ D Y G+ L G + S + L+ ++ ++ + V+ R VK
Sbjct: 93 WWEGQDAYAAAAGL--LRPHGRYAVSDATWALHLLCLQASLPLATYQPLSVVLPMRRAVK 150
Query: 129 SDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTIIASG 188
++E+ + A AD A + G+ ERE+AA + L++ +G + F T++ +G
Sbjct: 151 DEQEMARLTAAAAAADTAYEEVLGLRFGGRSERELAADLAGLLRAHGHSRVDF-TVVGAG 209
Query: 189 YRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQ 248
+A PH D+ I GD+VV+D G L + Y DI RTV VG+P +++R ++E V AQ
Sbjct: 210 PHAADPHHRPGDRVIGDGDMVVLDFGGLKDGYGFDIARTVHVGAPTDEERRVHETVRAAQ 269
Query: 249 KKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYDETVLK 308
+ A A RPG++ +E+D AR +I+E G+ + GHGVG+ HE P + + +E L+
Sbjct: 270 RAAFGAVRPGVSCQEVDRAARAVIEEAGHAGHGARRTGHGVGVTTHEPPYLVEGEEQPLE 329
Query: 309 EGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTEREL 350
GM ++EPGI++P GVRIED + T+ G RRL T EL
Sbjct: 330 PGMCFSLEPGIHLPDRFGVRIEDVVTCTEDGGRRLNTTSHEL 371
>emb|CAB93372.1| (AL357523) putative peptidase [Streptomyces coelicolor A3(2)]
Length = 368
Score = 164 bits (412), Expect = 1e-39
Identities = 110/358 (30%), Positives = 181/358 (49%), Gaps = 18/358 (5%)
Query: 10 RIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYV----PELEYEMAK 65
R+ E N A L+++ N+ YL+GA+P G +L+ L V P+ +
Sbjct: 11 RLRERCNAGGSAAALVSRPANVRYLAGAAP--HGAVLLLGRTEDLLVCSGSPDDRPTQGR 68
Query: 66 EESKIPVEKFKRRDDFYKVF-------EGVKVLGIEGS-LSYSFVEDLKEKGKISEFKKV 117
+ +PV V +G + L E L+ ++ +
Sbjct: 69 PDESLPVRALSGPGGDPAVAATDLAADQGAESLATEDHHLTVVRHRAMRSVAPALRLTDL 128
Query: 118 DDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAE 177
++++R+VK +EEI + EIAD+A+ +E + G+ ER +A ++E + +GA+
Sbjct: 129 GQAVEQLRVVKDEEEISCLRIGAEIADQALGELLESILVGRTERHLALELERRLVDHGAD 188
Query: 178 KPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVG-SPNEK 236
PAF T + +G S +D+R+E+GD + + LGA Y Y +I RT V+G SP +
Sbjct: 189 GPAFPTSVGTGPNSGRRGHRPTDRRVEEGDFLSVCLGATYRGYRCEIGRTFVIGTSPADW 248
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEW 296
Q E+Y++V AQ+ EA PG +++D AR + GY ++ GHGVGLEI E
Sbjct: 249 QIELYDLVFSAQRAGREALAPGAACRDVDRAARQPLDSAGYAEHLPALTGHGVGLEIDED 308
Query: 297 PGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVI---TKTGARRLTKTERELI 351
P ++ L + +T+EPG+++P GGVRI+DT+V+ G LT T +EL+
Sbjct: 309 PQLAPAAMGKLDACVPVTVEPGVHLPGRGGVRIDDTLVVRPEADGGPELLTITTKELL 366
>gi|11499616 X-pro aminopeptidase (pepQ) [Archaeoglobus fulgidus]
>gi|7445466|pir||A69504 X-pro aminopeptidase (pepQ)
homolog - Archaeoglobus fulgidus
>gi|2648501|gb|AAB89220.1| (AE000962) X-pro
aminopeptidase (pepQ) [Archaeoglobus fulgidus]
Length = 363
Score = 149 bits (372), Expect = 5e-35
Identities = 114/363 (31%), Positives = 186/363 (50%), Gaps = 31/363 (8%)
Query: 11 IIEFMNENSIDAVLI---TKNPNIYYLSGASPLAGGYILVNNDGAT-LYVPELEYEMAKE 66
I EF+ ++S D +++ + N N YY + + DG+ L VPE+E + A+
Sbjct: 2 IAEFLRKHSADFIILHGSSSNANFYYATKFKTYDPLTYIAGIDGSDILIVPEMEKKRAER 61
Query: 67 ESKIP----------VEKFKRRDDFYKVFEGVKVLGI-EGSLSYSFVEDLK------EKG 109
ES++ +EK K D K + + V + EG + + E
Sbjct: 62 ESRVKEIVSLNDLGYMEKLKELGDAKKAYLEILVAILKEGRCRKLLIPEEMPTYISFELM 121
Query: 110 KISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEY 169
K E + V + +RI+KS E++ I + V A+E + E A +E
Sbjct: 122 KHFEVEVVKNPFSTLRIIKSSSEVEKIRDTSNAILRCVKWAVENFSFRTCEGMRRA-IE- 179
Query: 170 LMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVV 229
+K+ A +TI ++G SA PH + + IE+ ++ + +L + Y SD TRT+
Sbjct: 180 -LKLFSEGYLAENTICSTGKSSADPHEIGKGE-IEEHVVLDVFPKSLDHLYYSDFTRTLF 237
Query: 230 VGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGY----GDYFIHSL 285
V N + E+Y+ V++AQ+KA+ R G+ K++ ++ + +G+ G+ FIHS
Sbjct: 238 VRE-NAELEEMYKAVVDAQEKALSMIRDGVDAKDVHQAVKDTLNSHGFKTEKGEGFIHST 296
Query: 286 GHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTK 345
GHGVGLE+HE P +S+ LK+GMV+T+EPG+Y K GGVR+EDT+V+ K G LT
Sbjct: 297 GHGVGLEVHEEPRISELS-VELKKGMVVTVEPGLYYSKVGGVRVEDTVVVRKNGCEVLTP 355
Query: 346 TER 348
E+
Sbjct: 356 FEK 358
>pir||A83084 probable metallopeptidase PA4498 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9950737|gb|AAG07886.1|AE004863_6 (AE004863) probable
metallopeptidase [Pseudomonas aeruginosa]
Length = 405
Score = 148 bits (369), Expect = 1e-34
Identities = 108/354 (30%), Positives = 179/354 (50%), Gaps = 25/354 (7%)
Query: 14 FMNENSIDAVLITKNPNIYYLSG-----ASPLAGGYILVNNDGATLYV-PELEYEMAKEE 67
+M E+ I A + N+ Y SG + L G L+ +GA Y+ P E ++
Sbjct: 42 WMGEHGIAAAYLHAGSNLRYFSGVQWHPSERLVGA--LLPAEGALEYLAPAFEEGTVRDF 99
Query: 68 SKIP--VEKFKRRDDFYKVF-EGVKVLGIEG--------SLSYSFVEDLKEKGKISEFKK 116
+ + ++ D Y++ + ++ LG+ SL + E L+++ F
Sbjct: 100 QVVDGAIHTWEEHQDPYRLLLDRLEALGVGERSTVALCPSLPFGMFERLRQQAPGRNFVS 159
Query: 117 VDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA 176
+I + R+ KS EE+ ++++A ++ + AA + EG E+A + + GA
Sbjct: 160 AAPLIDQGRMRKSAEELALMQRAKDMTLEVQKAAASILREGISTTEVAEFIHQAHRKVGA 219
Query: 177 EKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
F I+ G SA PHGV + ++ GD+V+ID G + Y SDITR+ V G+P+ +
Sbjct: 220 PGSTF-CIVLFGAASAFPHGVKHAQVLKDGDMVLIDTGCQVHGYQSDITRSYVFGTPSAR 278
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYG-DYFI----HSLGHGVGL 291
QRE + + +AQ A EAAR G + +D+ AR ++ G G DY + H GHG+G+
Sbjct: 279 QREFWGMERDAQLAAFEAARLGQPCEAVDAAARRSLEANGLGPDYRLPGLPHRTGHGIGM 338
Query: 292 EIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTK 345
++HE P + + D T L GM + EP I +P G+R+ED +TK G R T+
Sbjct: 339 DVHEGPYLVRGDRTPLDVGMCFSNEPMICVPGEFGIRLEDHFYMTKEGPRWFTQ 392
>gb|AAD18095.1| (AC006416) Similar to gi|1573829 HI0816 aminopeptidase P homolog
(pepP) from Haemophilus influenzae genome gb|U32764.
[Arabidopsis thaliana]
Length = 451
Score = 147 bits (368), Expect = 1e-34
Identities = 105/392 (26%), Positives = 193/392 (48%), Gaps = 62/392 (15%)
Query: 9 KRIIEFMNENSI------------DAVLIT--KNPNIYYLSGASPLAGGYILVNNDGATL 54
K+++E + ENS+ D V T ++ + YL+G G +L + G +
Sbjct: 20 KKLVELLPENSLAIISSAPVKMMTDVVPYTFRQDADYLYLTGCQQPGGVAVLSDERGLCM 79
Query: 55 YVPE----------------LEYEMAKEESKIPVEKFKR-RDDFY----KVFEGVKVLGI 93
++PE E+ K + P+ K D KVF V+
Sbjct: 80 FMPESTPKDIAWEGEVAGVDAASEVFKADQAYPISKLPEILSDMIRHSSKVFHNVQ---- 135
Query: 94 EGSLSYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEE 153
S Y+ ++D + + + K + + E+R++KS E+K++ ++ IA + ++ +
Sbjct: 136 SASQRYTNLDDFQNSASLGKVKTLSSLTHELRLIKSPAELKLMRESASIACQGLLKTMLH 195
Query: 154 VTEGKKEREIAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDL 213
E ++A+VEY ++ GA++ AF+ ++ G +++ H +D+RI+ GDLV++D+
Sbjct: 196 SKGFPDEGILSAQVEYECRVRGAQRMAFNPVVGGGSNASVIHYSRNDQRIKDGDLVLMDM 255
Query: 214 GALYNHYNSDITRT-VVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNII 272
G + Y SD+TRT G + Q E+Y+++L+ K+ ++ +PG T ++L++ + ++
Sbjct: 256 GCELHGYVSDLTRTWPPCGKFSSVQEELYDLILQTNKECIKQCKPGTTIRQLNTYSTELL 315
Query: 273 -----------KEYGYGDYFIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYI 321
Y S+GH +G+++H+ V YD L+ G VITIEPG+YI
Sbjct: 316 CDGLMKMGILKSRRLYHQLNPTSIGHYLGMDVHDSSAVG-YDRP-LQPGFVITIEPGVYI 373
Query: 322 PKFG---------GVRIEDTIVITKTGARRLT 344
P G+RIED ++IT+TG LT
Sbjct: 374 PSSFDCPERFQGIGIRIEDDVLITETGYEVLT 405
>sp|P44881|AMPP_HAEIN XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE) (AMINOPEPTIDASE P II)
(APP-II) (AMINOACYLPROLINE AMINOPEPTIDASE)
>gi|1073841|pir||B64096 X-Pro aminopeptidase (EC
3.4.11.9) II - Haemophilus influenzae (strain Rd KW20)
>gi|1573829|gb|AAC22475.1| (U32764) aminopeptidase P
(pepP) [Haemophilus influenzae Rd]
Length = 430
Score = 146 bits (366), Expect = 3e-34
Identities = 86/253 (33%), Positives = 144/253 (55%), Gaps = 28/253 (11%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
++ EMR++KS EI+++++A +I + A++ + E EI + + + + A P
Sbjct: 162 MLSEMRLIKSPNEIRLMQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFP 221
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQR 238
++++I+A G + + H +D+ + GDLV+ID G + Y DITRT V G ++ QR
Sbjct: 222 SYNSIVAGGSNACILHYTENDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQR 281
Query: 239 EIYEIVLEAQKKAVEAARPGITTKEL-DSIAR-----------------NIIKEYGYGDY 280
EIYE+VL+AQK+A+E PG + K+ D + R +I++ Y +
Sbjct: 282 EIYELVLKAQKRAIELLVPGNSIKQANDEVIRIKTQGLVDLGILKGDVDTLIEQQAYRQF 341
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIP---------KFGGVRIED 331
++H LGH +GL++H+ Q + +L+ GMVIT+EPGIYI K GVRIED
Sbjct: 342 YMHGLGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIED 401
Query: 332 TIVITKTGARRLT 344
+++T+ G + LT
Sbjct: 402 NLLMTEYGNKILT 414
>sp|P15034|AMPP_ECOLI XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE) (AMINOPEPTIDASE P II)
(APP-II) (AMINOACYLPROLINE AMINOPEPTIDASE)
>gi|67530|pir||DPECP X-Pro aminopeptidase (EC 3.4.11.9)
II - Escherichia coli >gi|216529|dbj|BAA00299.1|
(D00398) aminopeptidase P precursor [Escherichia coli]
>gi|216627|dbj|BAA14325.1| (D90281) PepP (proline amino
peptidaseII) [Escherichia coli]
>gi|882438|gb|AAA69076.1| (U28377) ORF_f441; third start
codon [Escherichia coli] >gi|1789275|gb|AAC75946.1|
(AE000374) proline aminopeptidase P II [Escherichia coli
K12] >gi|363847|prf||1505351A aminopeptidase P
[Escherichia coli]
Length = 441
Score = 143 bits (358), Expect = 2e-33
Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 28/253 (11%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
V+ EMR+ KS EEI ++ +A EI A A+E+ G E + ++ + +GA P
Sbjct: 169 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 228
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQR 238
+++TI+ SG + H ++ + GDLV+ID G Y Y DITRT V G + QR
Sbjct: 229 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 288
Query: 239 EIYEIVLEAQKKAVEAARPGITTKE------------------LDSIARNIIKEYGYGDY 280
EIY+IVLE+ + ++ RPG + E L +I + + +
Sbjct: 289 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 348
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFG---------GVRIED 331
F+H L H +GL++H+ Q +L+ GMV+T+EPG+YI G+RIED
Sbjct: 349 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIED 408
Query: 332 TIVITKTGARRLT 344
IVIT+TG LT
Sbjct: 409 DIVITETGNENLT 421
>pdb|1A16| Aminopeptidase P From E. Coli With The Inhibitor Pro-Leu
Length = 440
Score = 143 bits (358), Expect = 2e-33
Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 28/253 (11%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
V+ EMR+ KS EEI ++ +A EI A A+E+ G E + ++ + +GA P
Sbjct: 168 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 227
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQR 238
+++TI+ SG + H ++ + GDLV+ID G Y Y DITRT V G + QR
Sbjct: 228 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 287
Query: 239 EIYEIVLEAQKKAVEAARPGITTKE------------------LDSIARNIIKEYGYGDY 280
EIY+IVLE+ + ++ RPG + E L +I + + +
Sbjct: 288 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 347
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFG---------GVRIED 331
F+H L H +GL++H+ Q +L+ GMV+T+EPG+YI G+RIED
Sbjct: 348 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIED 407
Query: 332 TIVITKTGARRLT 344
IVIT+TG LT
Sbjct: 408 DIVITETGNENLT 420
>pdb|1AZ9| Aminopeptidase P From E. Coli
Length = 457
Score = 143 bits (358), Expect = 2e-33
Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 28/253 (11%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
V+ EMR+ KS EEI ++ +A EI A A+E+ G E + ++ + +GA P
Sbjct: 185 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 244
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQR 238
+++TI+ SG + H ++ + GDLV+ID G Y Y DITRT V G + QR
Sbjct: 245 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 304
Query: 239 EIYEIVLEAQKKAVEAARPGITTKE------------------LDSIARNIIKEYGYGDY 280
EIY+IVLE+ + ++ RPG + E L +I + + +
Sbjct: 305 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 364
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFG---------GVRIED 331
F+H L H +GL++H+ Q +L+ GMV+T+EPG+YI G+RIED
Sbjct: 365 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIED 424
Query: 332 TIVITKTGARRLT 344
IVIT+TG LT
Sbjct: 425 DIVITETGNENLT 437
>pdb|1JAW| Aminopeptidase P From E. Coli Low Ph Form
Length = 440
Score = 143 bits (358), Expect = 2e-33
Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 28/253 (11%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
V+ EMR+ KS EEI ++ +A EI A A+E+ G E + ++ + +GA P
Sbjct: 168 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 227
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQR 238
+++TI+ SG + H ++ + GDLV+ID G Y Y DITRT V G + QR
Sbjct: 228 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 287
Query: 239 EIYEIVLEAQKKAVEAARPGITTKE------------------LDSIARNIIKEYGYGDY 280
EIY+IVLE+ + ++ RPG + E L +I + + +
Sbjct: 288 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 347
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFG---------GVRIED 331
F+H L H +GL++H+ Q +L+ GMV+T+EPG+YI G+RIED
Sbjct: 348 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIED 407
Query: 332 TIVITKTGARRLT 344
IVIT+TG LT
Sbjct: 408 DIVITETGNENLT 420
>pir||H82833 proline dipeptidase XF0220 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9105027|gb|AAF83033.1|AE003875_8 (AE003875)
proline dipeptidase [Xylella fastidiosa]
Length = 400
Score = 142 bits (354), Expect = 6e-33
Identities = 101/362 (27%), Positives = 171/362 (46%), Gaps = 19/362 (5%)
Query: 1 MNIMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSG-----ASPLAGGYILVNNDGATLY 55
+N ++I++ M +DA+L+ ++ Y +G + L IL++ D L
Sbjct: 29 VNEYAQRIEQARVLMRIQGVDALLVGAGASLRYFTGVPWHASERLVALLILLSGD-PLLI 87
Query: 56 VPELEYEMAKEESKIPVEK--FKRRDDFYKVF------EGVKVLGIEGSLSYSFVEDLKE 107
P E +PV K ++ +D Y + G + L ++ +++ L
Sbjct: 88 CPVFEEGSLDAVLLLPVGKRLWEEHEDPYALVAQVMREHGARTLALDSGATFAVHTGLCR 147
Query: 108 KGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKV 167
++ R+ KS E+ +I++AC++ + A EG + +
Sbjct: 148 HVDARAITDATAIVDGCRLCKSPAELALIQQACDMTLQVQRLAAGIAHEGIGTDAMVRFI 207
Query: 168 EYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRT 227
+ + GA+ + I+ G +A PHG+ + + +G LV+ID G Y+SDITRT
Sbjct: 208 DEAHRALGADNGSTFCIVQFGQATAFPHGIPGVQHLVEGQLVLIDTGCTVQGYHSDITRT 267
Query: 228 VVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYG-DYFI---- 282
+ G P++ QR I+++ AQ A A RPG+ + +D AR +++ G G DY +
Sbjct: 268 WIYGKPSDHQRRIWDLEQAAQAAAFAAVRPGVACEVVDRAARQVLELGGLGPDYRLPGLP 327
Query: 283 HSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARR 342
H GHG GL IHE P + + + TVL GM + EP I +P GVR+ED +T+ GA
Sbjct: 328 HRTGHGCGLAIHEAPYLVRGNHTVLCPGMCASDEPMIVVPGHFGVRLEDHFYVTEDGAHW 387
Query: 343 LT 344
T
Sbjct: 388 FT 389
>gb|AAG10442.1|AF279106_4 (AF279106) predicted Xaa-Pro aminopeptidase [uncultured
proteobacterium EBAC31A08]
Length = 431
Score = 141 bits (353), Expect = 8e-33
Identities = 104/384 (27%), Positives = 183/384 (47%), Gaps = 56/384 (14%)
Query: 18 NSIDAVLITKNPNIYYLSGASPLAGGYILVNND---GATLYVPELE-------------- 60
N+ + + + + YYLSG + +LVNN + ++VPE +
Sbjct: 34 NADSSYNLRQESSFYYLSGFCEPSSLMVLVNNGKSIDSIIFVPEKDKLKEIWDGYRAGPE 93
Query: 61 -------YEMAKEESKIPVEKFKRRDDFYKVFEGV-KVLGIEGS-LSYSFVEDLKEK-GK 110
++ A E +K + KVF + K G + + ++ + K++ K
Sbjct: 94 GAINDFLFDQAFENNKSDALMPEILQGLEKVFYSIGKKNGFDQKVIDWTCAANSKDRHSK 153
Query: 111 ISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYL 170
+ ++ +R++K EI I+++ACEI+ ++ + ++ + G E+EI A Y
Sbjct: 154 SIDIIDGSSMVGNLRLIKDKHEIDIMKRACEISAESYIEVMKSIKPGDNEQEIEALFLYE 213
Query: 171 MKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTV-V 229
G PA+ I+A G + + H + +DK + DL+++D G Y Y SDITRT V
Sbjct: 214 FAKRGGRFPAYTPIVAGGEGACVLHYIENDKELASSDLILVDAGCEYKMYASDITRTFPV 273
Query: 230 VGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNII----------------- 272
G +++Q +IY IV +A A++A + G + E ++ +I
Sbjct: 274 SGKFSDEQLQIYNIVHKANLAAIDAVKTGNSIMEPQMVSEKVITEGLVELGILSGDVNQL 333
Query: 273 -KEYGYGDYFIHSLGHGVGLEIHEWPGVSQYDETV-LKEGMVITIEPGIYIP-------- 322
K + D+++H +GH +GL++H+ + DE + K GM+ TIEPGIYI
Sbjct: 334 HKNGAFKDFYMHKVGHWLGLDVHDVGDYMEGDEFMKFKPGMITTIEPGIYISSAMDVDDK 393
Query: 323 -KFGGVRIEDTIVITKTGARRLTK 345
K G+RIED I++T +G LT+
Sbjct: 394 WKGIGIRIEDDILVTDSGNINLTE 417
>gb|AAB96776.1| (AF041033) aminopeptidase [Shigella flexneri]
Length = 441
Score = 141 bits (353), Expect = 8e-33
Identities = 86/253 (33%), Positives = 130/253 (50%), Gaps = 28/253 (11%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
V+ EMR+ KS EEI ++ +A EI A A+E+ G E + ++ + +GA P
Sbjct: 169 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 228
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQR 238
+++TI+ SG + H ++ + GDLV+ID G Y Y DITRT V G + QR
Sbjct: 229 SYNTIVGSGENGCILHYTENESELRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 288
Query: 239 EIYEIVLEAQKKAVEAARPGITTKE------------------LDSIARNIIKEYGYGDY 280
EIY+IVLE+ + ++ RPG + E L +I + + +
Sbjct: 289 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGNVDELIAQNAHRPF 348
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFG---------GVRIED 331
F+H L H +GL++H+ Q +L+ GMV+T+EP +YI G+RIED
Sbjct: 349 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPVLYIAPDADVPEQYRGIGIRIED 408
Query: 332 TIVITKTGARRLT 344
IVIT+TG LT
Sbjct: 409 DIVITETGNENLT 421
>pir||S76440 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1653657|dbj|BAA18569.1| (D90915) aminopeptidase P
[Synechocystis sp.]
Length = 441
Score = 140 bits (349), Expect = 2e-32
Identities = 86/262 (32%), Positives = 138/262 (51%), Gaps = 37/262 (14%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP 179
++ +R VKS+ E+ ++ +AC+++ A A+E G E ++ A++E + + G P
Sbjct: 168 LVHPLRQVKSETELALLRRACDLSAIAHQRAMEFARPGHYEYQVQAELEIIFRREGGLGP 227
Query: 180 AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQR 238
A+ +I+A+G + + H + +D ++ GDL++ID G Y +YN DITRT + G + +QR
Sbjct: 228 AYPSIVAAGKNACILHYINNDCPLQDGDLLLIDAGCAYGYYNGDITRTFPINGKFSPEQR 287
Query: 239 EIYEIVLEAQKKAVEAARPGITTKELDSIA------------------RNIIKEYGYGDY 280
+YEIVL AQ+ A+ + G E A IIKE Y +
Sbjct: 288 TLYEIVLTAQEAAIAKVQAGNPYHEYHDAAVSVIVDGLMDLGLLVGNKEEIIKEEKYKPF 347
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDE--TVLKEGMVITIEPGIYI-----PKFG-------- 325
++H GH +GL++H+ Q E TVL+ G V+T+EPGIYI P G
Sbjct: 348 YMHRTGHWLGLDVHDAGNYKQDKETWTVLEPGQVLTVEPGIYIAPDIKPAEGQPEVPEQW 407
Query: 326 ---GVRIEDTIVITKTGARRLT 344
G+RIED +++T G LT
Sbjct: 408 RGIGIRIEDDVLVTAQGPDVLT 429
>pir||B75217 x-pro dipeptidase PAB2178 - Pyrococcus abyssi (strain Orsay)
>gi|5457694|emb|CAB49185.1| (AJ248283) x-pro dipeptidase
[Pyrococcus abyssi]
Length = 365
Score = 139 bits (348), Expect = 3e-32
Identities = 104/360 (28%), Positives = 174/360 (47%), Gaps = 26/360 (7%)
Query: 3 IMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYE 62
I ++++R E + EN+ID +I + Y +G L ++ T+ V + E E
Sbjct: 14 IFKKRVERFQELLRENNIDGAVIRTLSSFIYFTGTKWLRPSLLIPAEGEPTVLVVKGEAE 73
Query: 63 MAKEESKIP--VEKFKRRDDFYKVFEGVK---------VLGIEGSLSYSFVEDLKEKGKI 111
+ K+ S I VE K + V + +K GIE F +
Sbjct: 74 LFKQRSWIEDVVEYQKVEELMATVVKWIKDNGMKRVGLEFGIERDAYLIFYKIFLRLNPS 133
Query: 112 SEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM 171
E + D+ +R++K + E++ I KA +IA K + A EE+ GK E EIAA+V +
Sbjct: 134 IEVVDILDLTMSLRMIKDEWELENIRKAGKIALKGMRVAEEEIKPGKSELEIAAEVVREL 193
Query: 172 KMNGAEKPAFDTIIASGYRSALPHGVAS---DKRIEKGDLVVIDLGALYNHYNSDITRTV 228
+NG+E P Y S P A D ++ + +V + +G +NHY +++ RT
Sbjct: 194 MLNGSEDPKV-------YVSVTPRAHAEPFRDLKVPENGIVTVVIGTDWNHYYANMARTF 246
Query: 229 VVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHG 288
+VG P E+ ++ E+ EA K A+E R G+ ++ + KE G+G+Y + HG
Sbjct: 247 IVGDPGERVKKAIEVKKEALKLALEETRVGVPISAVEKKIEHFFKERGFGEYHLAGYTHG 306
Query: 289 VGLEIHEWP---GVSQYDETVLKEGMVIT-IEPGIYIPKFGGVRIEDTIVITKTGARRLT 344
VGL I E P V T ++E MV++ I P + +P+ G ++ E+T ++ K R+T
Sbjct: 307 VGLLIEEPPIATIVVPQRATRIQENMVLSIIHPPLMLPE-GAIKYENTYIVKKDKLERVT 365
>gb|AAG19595.1| (AE005049) X-pro aminopeptidase homolog; PepQ2 [Halobacterium sp.
NRC-1]
Length = 391
Score = 139 bits (347), Expect = 4e-32
Identities = 114/391 (29%), Positives = 188/391 (47%), Gaps = 52/391 (13%)
Query: 4 MDEKIKRIIEFMNENSIDAVLI---TKNPNIYYLSGASPLAGGYILVNNDGATLYVPELE 60
MD ++ EF+ ++ +D N ++YYL+G + + + V LE
Sbjct: 1 MDPDFSQLDEFLEDSGVDGYAFHDDDSNSDLYYLAGFDAPDPFFAVYTPAQTGVLVSPLE 60
Query: 61 YEMAKEESKIPV-------------EKFKRRDDFYKVF-EGVKVLGIEG-SLSYSF---V 102
Y A + ++ V E++ R +V E V LG E ++ F
Sbjct: 61 YGRASKAARADVVARHSDYDLQAKREEYGPRAAKERVLAEFVADLGCESLAVGERFPVGT 120
Query: 103 EDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKERE 162
D +I+ D+V++++R K++ EI+ + +A + A++A MA EE+ G +
Sbjct: 121 ADALRDHEITVEPDEDNVVEDIRATKTEAEIEHVREA-QRANEAAMARAEELIRGADRED 179
Query: 163 ---------------IAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGD 207
+ ++E + +G DTI+A G ++A H S + D
Sbjct: 180 GVLVRDDGQPLTSEYVRQEIEIELLRHGCALD--DTIVAGGAQAADAHERGSGP-LPADD 236
Query: 208 LVVIDL--GALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELD 265
VV+D+ + + Y+SD+TRT G P++ RE Y + A + A++A PG+T + ++
Sbjct: 237 PVVVDIFPRSKDSKYHSDMTRTFANGDPSDAHRERYAVTRAAFEAALDAIEPGVTGEAVN 296
Query: 266 SIARNIIKEYGYGDYF---------IHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIE 316
++ ++GY + F IHS GHGVGL++HE P VSQ + L G VITIE
Sbjct: 297 QAVIDVFDDHGYPNVFADPDTESGFIHSTGHGVGLDVHEMPAVSQGGDE-LHAGNVITIE 355
Query: 317 PGIYIPKFGGVRIEDTIVITKTGARRLTKTE 347
PG+Y P GGVRIED +V+T+ G LT E
Sbjct: 356 PGLYEPGEGGVRIEDIVVVTEDGYENLTDYE 386
>pir||D71204 hypothetical protein PH1902 - Pyrococcus horikoshii
>gi|3258344|dbj|BAA31027.1| (AP000007) 365aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 365
Score = 138 bits (344), Expect = 1e-31
Identities = 101/360 (28%), Positives = 172/360 (47%), Gaps = 26/360 (7%)
Query: 3 IMDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYE 62
I ++++R E + EN+ID +I + Y +G L ++ + V + E E
Sbjct: 14 IFKKRVERFQELLKENNIDGAVIRTLSSFIYFTGTKWLRPSLLIPAEGEPRVLVVKGEAE 73
Query: 63 MAKEESKIP--VEKFKRRDDFYKVFEGVKV---------LGIEGSLSYSFVEDLKEKGKI 111
+ KE S I VE K + V + ++ GIE F +
Sbjct: 74 LFKERSWIEDVVEYQKAEELMLTVVKWIRENEMKRVGLEFGIERDAYLIFYKIFLRLNPT 133
Query: 112 SEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM 171
E + D+ ++R++K + E+ I KA +IA K + A EE+ G+ E EIAA+V +
Sbjct: 134 VEVVDILDLTMKLRMIKDEWELDNIRKAGKIALKGMRVAEEEIKPGRTELEIAAEVTREL 193
Query: 172 KMNGAEKPAFDTIIASGYRSALPHGVAS---DKRIEKGDLVVIDLGALYNHYNSDITRTV 228
+NG+E P Y S P A D ++ + +V + +G +NHY +++ RT
Sbjct: 194 MLNGSEDPKV-------YVSVTPRAHAEPFRDLKVPENGVVTVVIGTDWNHYYANMARTF 246
Query: 229 VVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHG 288
++G P E+ ++ E+ EA K A+E + G+ ++ KE G+GDY + HG
Sbjct: 247 IIGDPGERVKKAIEVKKEAIKLALEETKVGVPISTVEKKIEQFFKERGFGDYHLSGYTHG 306
Query: 289 VGLEIHEWP---GVSQYDETVLKEGMVIT-IEPGIYIPKFGGVRIEDTIVITKTGARRLT 344
VGL I E P V ++E MV++ I P + +P+ G ++ E+T ++ K G R+T
Sbjct: 307 VGLLIEEPPIATIVVPQRAAKIQENMVLSIIHPPLMLPE-GAIKYENTYIVKKDGLERVT 365
>pir||H82992 aminopeptidase P PA5224 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9951532|gb|AAG08609.1|AE004935_6
(AE004935) aminopeptidase P [Pseudomonas aeruginosa]
Length = 444
Score = 136 bits (340), Expect = 3e-31
Identities = 86/266 (32%), Positives = 139/266 (51%), Gaps = 36/266 (13%)
Query: 112 SEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM 171
+EF +D ++ + R+ KS E+K++ A E++ +A + A+E G E + A++EY
Sbjct: 160 NEFVALDHLLHDQRLYKSANEVKVMRYAAEVSARAHIRAMEVCRPGLFEYHLEAELEYEF 219
Query: 172 KMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV- 230
+ GA+ PA+ +I+A+G + + H +D I+ GDL++ID G + Y SDITRT
Sbjct: 220 RKGGAKMPAYGSIVAAGRNACILHYRENDAAIKDGDLILIDAGCEIDCYASDITRTFPAN 279
Query: 231 GSPNEKQREIYEIVLEAQKKAVEAARPGITTKE------------------LDSIARNII 272
G + +Q+ IYE+VLEA A + PG E L+ +I
Sbjct: 280 GRFSPEQKAIYELVLEANMAAFDYIAPGRHWNEAHEATVRVITAGLVRLGLLEGDVDELI 339
Query: 273 KEYGYGDYFIHSLGHGVGLEIHEWPGVSQY----DETVLKEGMVITIEPGIYIPKFG--- 325
Y +++H GH +G+++H+ V +Y + VL+ GM +T+EPGIYI
Sbjct: 340 AHEAYKAFYMHRAGHWLGMDVHD---VGEYRVGGEWRVLEPGMAMTVEPGIYIAPDNTTV 396
Query: 326 -------GVRIEDTIVITKTGARRLT 344
GVRIED +V+T+ G LT
Sbjct: 397 AKKWRGIGVRIEDDVVVTRNGCEVLT 422
>pir||T39750 probable dipeptidase - fission yeast (Schizosaccharomyces pombe)
>gi|5263087|emb|CAB45933.1| (AL080287) hypothetical
dipeptidase; metallopeptidase family
[Schizosaccharomyces pombe]
Length = 451
Score = 131 bits (327), Expect = 9e-30
Identities = 104/358 (29%), Positives = 186/358 (51%), Gaps = 39/358 (10%)
Query: 9 KRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGGY-------ILVNND-------GATL 54
+R+ + E+ +DA+++ ++ Y + + + G I+ ++D + +
Sbjct: 82 RRLSAALREDKLDALIMEPTVSMDYFANITTGSWGLSERPFLGIIFSDDEPYPGDVASRI 141
Query: 55 Y--VPELEYEMAKEESKIPVE-KFKRRDDFYKVFE------GVKVLGIEGSLSYSFVEDL 105
Y VP+ E AKE ++ K+ D+ ++ G L I+G++ + L
Sbjct: 142 YFLVPKFELPRAKELVGKNIDAKYITWDEDENPYQVLYDRLGPLKLMIDGTVRNFIAQGL 201
Query: 106 KEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEE-VTEGKKEREIA 164
+ G + F V + +R +KS E+ I+ + IA A + +++ + G E+E+A
Sbjct: 202 QYAG-FTTFG-VSPRVASLREIKSPAEVDIMSRV-NIATVAAIRSVQPCIKPGITEKELA 258
Query: 165 AKVEYLMKMNGA---EKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYN 221
+ L G E P I+ G R+A+PHG S++R++K + V++D+G Y+
Sbjct: 259 EVINMLFVYGGLPVQESP----IVLFGERAAMPHGGPSNRRLKKSEFVLMDVGTTLFGYH 314
Query: 222 SDITRTVVVGSPN--EKQREIYEIVLEAQKKAVEAARPGITTK--ELDSIARNIIKEYGY 277
SD TRTV+ E+ +++ +V +AQ ++ T E+D AR +IK+ GY
Sbjct: 315 SDCTRTVLPHGQKMTERMEKLWNLVYDAQTAGIQMLSHLSNTSCAEVDLAARKVIKDAGY 374
Query: 278 GDYFIHSLGHGVGLEIHEWPGVSQYDE-TVLKEGMVITIEPGIYIPKFGGVRIEDTIV 334
G+YFIH LGHG+GLE HE ++ ++ T +++G V T+EPGIYIP G+RIED ++
Sbjct: 375 GEYFIHRLGHGLGLEEHEQTYLNPANKGTPVQKGNVFTVEPGIYIPDEIGIRIEDAVL 432
>dbj|BAB05458.1| (AP001513) Xaa-Pro dipeptidase [Bacillus halodurans]
Length = 406
Score = 128 bits (318), Expect = 1e-28
Identities = 94/370 (25%), Positives = 179/370 (47%), Gaps = 37/370 (10%)
Query: 15 MNENSIDAVLITKNPNIYYLSGASPLAGGY----ILVNNDGATLYVPE-------LEYEM 63
M + ID +L++ N+YYLSG S + ++ +D L++ ++
Sbjct: 18 MMDEGIDVLLVSNPSNMYYLSGYSAWSFYVHQLLVVTLDDPQPLWIGREMDASSVVKTTW 77
Query: 64 AKEESKIPV------EKFKRRDDFY-----KVFEGVKVLGIEGSLSYSF---VEDLKEKG 109
E+ IP + + DF ++ +G + +G+E Y + L++
Sbjct: 78 LDEQQVIPYPDHYVQSETRHPMDFVTNILKEIGQGNRTIGVEMDAHYFTGLCYQRLQQGL 137
Query: 110 KISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEY 169
FK +I +R++KSD+EI+++ KA +IA+ A+ AA + V G +E ++AA + +
Sbjct: 138 TNGTFKNATTLINWVRLIKSDQEIQVMRKAAKIAENAMKAAYDTVNVGVRECDVAAAISH 197
Query: 170 LMKMN----GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDIT 225
G + P+ ++ +G ++ PH +D+ ++GD + +++ Y Y+ I
Sbjct: 198 AQIKGTAEFGGDYPSIVPMLPTGENTSCPHLTWTDRTYQEGDYLTVEIAGCYKRYHVPIA 257
Query: 226 RTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSL 285
RTV +G E +E+ ++V+E + ++ RPG+ +E+ + I ++G+ L
Sbjct: 258 RTVSLGVAPEHVKELAKVVIEGIHETLQMIRPGVAAEEVAATWNQSISKHGFEKN--SRL 315
Query: 286 GHGVGLEI-HEW----PGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGA 340
G+ +GL +W + Q D T+LK M + PGI+ + GV I ++I IT G
Sbjct: 316 GYSIGLSFPPDWGEHTVSLRQGDRTLLKPNMTFHLMPGIWYEDY-GVEITESIRITDDGV 374
Query: 341 RRLTKTEREL 350
LT RE+
Sbjct: 375 ELLTNVSREI 384
>gi|6321118 Yfr006wp [Saccharomyces cerevisiae]
>gi|1175977|sp|P43590|YFH6_YEAST HYPOTHETICAL 61.8 KD
PEPTIDASE IN MPR1-GCN20 INTERGENIC REGION
>gi|1084731|pir||S56261 probable membrane protein
YFR006w - yeast (Saccharomyces cerevisiae)
>gi|836761|dbj|BAA09245.1| (D50617) YFR006W
[Saccharomyces cerevisiae]
Length = 535
Score = 120 bits (299), Expect = 2e-26
Identities = 109/402 (27%), Positives = 170/402 (42%), Gaps = 98/402 (24%)
Query: 27 KNPNIYYLSGASPLAGGYIL-VNNDGATLYVPELEYEMAKEESKIPVEKFKRRDDFYKVF 85
+N Y+LSG A + + D TL++P ++ E S +P+ +
Sbjct: 120 QNRYFYHLSGVDIPASAILFNCSTDKLTLFLPNIDEEDVIW-SGMPLS----------LD 168
Query: 86 EGVKVLGIEGSLSYSFVEDLKEKGK--------ISEFKKVDD----------------VI 121
E ++V I+ +L ++ DL +K K ++ V D +
Sbjct: 169 EAMRVFDIDEAL---YISDLGKKFKELQDFAIFTTDLDNVHDENIARSLIPSDPNFFYAM 225
Query: 122 KEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAF 181
E R +K EI+ I KAC+I+DK+ +A + + E +I A+ EY G +
Sbjct: 226 DETRAIKDWYEIESIRKACQISDKSHLAVMSALPIELNELQIQAEFEYHATRQGGRSLGY 285
Query: 182 DTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTV-VVGSPNEKQREI 240
D I SG H V + + I+ ++ID GA + Y SDITR G + RE+
Sbjct: 286 DPICCSGPACGTLHYVKNSEDIKGKHSILIDAGAEWRQYTSDITRCFPTSGKFTAEHREV 345
Query: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNII-----------KEYGYGD---------Y 280
YE VL+ Q +A+E +PG +L ++ ++ KE+ + +
Sbjct: 346 YETVLDMQNQAMERIKPGAKWDDLHALTHKVLIKHFLSMGIFKKEFSEDEIFKRRASCAF 405
Query: 281 FIHSLGHGVGLEIHEWPGVSQYDE-----------TVLKEGMVITIEPGIYIPKF----- 324
+ H LGH +GL++H+ G YD+ LKE MVIT EPG Y +F
Sbjct: 406 YPHGLGHMLGLDVHDVGGNPNYDDPDPMFRYLRIRRPLKENMVITNEPGCYFNQFLIKEF 465
Query: 325 ----------------------GGVRIEDTIVITKTGARRLT 344
GGVRIED I++TK G LT
Sbjct: 466 LEKHPERLEVVDMSVLKRYMYVGGVRIEDDILVTKDGYENLT 507
>gi|11559925 hypothetical protein LOC63929 [Homo sapiens]
>gi|9188414|emb|CAB97210.1| (AL365514) hypothetical
protein [Homo sapiens]
Length = 507
Score = 114 bits (283), Expect = 1e-24
Identities = 84/260 (32%), Positives = 137/260 (52%), Gaps = 33/260 (12%)
Query: 106 KEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAA 165
K K K+ + V +I+ +R++KS EI+ ++ A ++ +A + + +E + A
Sbjct: 228 KSKNKV---RGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYA 284
Query: 166 KVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDIT 225
K E+ + GA+ A+ ++A G RS H V +++ I+ G++V++D G + Y SDIT
Sbjct: 285 KFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDIT 344
Query: 226 RT-VVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNII----KEYGY--- 277
RT V G Q E+YE VLE Q+ + PG + + + S+ +I K+ G
Sbjct: 345 RTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKN 404
Query: 278 ----------GDYFIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIP----- 322
Y H +GH +G+++H+ P + + L+ GMVITIEPGIYIP
Sbjct: 405 IKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPR--SLPLQPGMVITIEPGIYIPEDDKD 462
Query: 323 ---KFG--GVRIEDTIVITK 337
KF GVRIED +V+T+
Sbjct: 463 APEKFRGLGVRIEDDVVVTQ 482
>pir||F82609 aminopeptidase P XF2009 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9107124|gb|AAF84811.1|AE004020_2 (AE004020)
aminopeptidase P [Xylella fastidiosa]
Length = 446
Score = 112 bits (278), Expect = 5e-24
Identities = 82/265 (30%), Positives = 137/265 (50%), Gaps = 37/265 (13%)
Query: 113 EFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMK 172
EF + ++ E R+ KS +EI +++ A +I+ +A +AA+ G E + A++E + +
Sbjct: 168 EFIDLGHLLHEQRLFKSYDEIVLLQCAADISVEAHLAALRYAHPGVSEYVLQAELERVFR 227
Query: 173 MNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-G 231
+ PA+ +I+A+G + + H A+ + GDLV+ID GA Y Y +DITRT V G
Sbjct: 228 AADS-CPAYTSIVAAGANACVLHYRANAECSRDGDLVLIDAGAEYRGYAADITRTFPVNG 286
Query: 232 SPNEKQREIYEIVLEAQKKAVEAARPGITTKE------------------LDSIARNIIK 273
+ QR +Y++V A A+ ARPG+ + L + +
Sbjct: 287 RFSPAQRALYDLVGAAYNVALAQARPGLPYEAGHLAAVQTLTEGLLRLGLLHGTLEDNLA 346
Query: 274 EYGYGDYFIHSLGHGVGLEIHEWPGVSQY----DETVLKEGMVITIEPGIYI-------- 321
+ Y ++ H GH +GL++H+ V Y + +L+ GMV TIEPG+Y+
Sbjct: 347 DQSYKRFYRHKTGHWLGLDVHD---VGDYRIDGESRLLEPGMVFTIEPGLYVLPDDTAVH 403
Query: 322 PKFG--GVRIEDTIVITKTGARRLT 344
PK+ G+R ED ++IT+ G LT
Sbjct: 404 PKWRGIGIRTEDDVLITEDGHCVLT 428
>gb|AAF45368.1| (AE002611) CG9581 gene product [Drosophila melanogaster]
Length = 545
Score = 111 bits (276), Expect = 9e-24
Identities = 72/252 (28%), Positives = 133/252 (52%), Gaps = 36/252 (14%)
Query: 121 IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA 180
++ MR++KS +E++++ + C+IA ++ + E G+ E + A ++Y +M A A
Sbjct: 262 LEAMRLLKSRDEMQLMRRTCDIASRSFNEVMAETRPGQSEHHLFAAIDYKCRMRNASYLA 321
Query: 181 FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRT-VVVGSPNEKQRE 239
+ ++A+G + + H VA+ + + + DLV++D G Y Y SDITRT G E QR
Sbjct: 322 YPPVVAAGKNATVIHYVANSQLLGQQDLVLMDAGCEYGGYTSDITRTWPASGVFTEPQRT 381
Query: 240 IYEIVLEAQKKAV-EAARPGITT----------------KELDSIARNI-----IKEYGY 277
+Y+++ + Q++ + +PG T +E+ + ++ + GY
Sbjct: 382 LYDMLHQLQEEIIGNVMKPGGETLDQLFETTCYKLGKYLQEIGLVGKSFSEYKELVSQGY 441
Query: 278 GDYFIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYI--------PKFG--GV 327
+ H + H +G+++H+ P V + T + GMV T+EPGIYI P+F G+
Sbjct: 442 -RFCPHHVSHYLGMDVHDTPHVPR--NTRIVPGMVFTVEPGIYIGQDCGDVPPEFRGIGI 498
Query: 328 RIEDTIVITKTG 339
RIED ++I + G
Sbjct: 499 RIEDDLLINENG 510
>sp|P55667|Y4TM_RHISN HYPOTHETICAL HYDROLASE/PEPTIDASE Y4TM >gi|2182643|gb|AAB91866.1|
(AE000098) Y4tM [Rhizobium sp. NGR234]
Length = 392
Score = 108 bits (267), Expect = 1e-22
Identities = 89/381 (23%), Positives = 175/381 (45%), Gaps = 39/381 (10%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLA----GGYILVNNDGATLYVPE-LE 60
+++ R+ + M ID +++T+ NI YL+G + ++ + +++ ++
Sbjct: 13 QRMLRVKQRMQAQDIDVLIVTEPANINYLTGYDAWSFYTVQALLVFQDVDLPMWIGRSID 72
Query: 61 YEMAKEESKIPVEKFKRRDDFY-----------------KVFEGVKVLGIEGSLSYSFVE 103
+ A + +P E+ D Y + K +G+E Y
Sbjct: 73 KQSAIVTTNLPDERIIPYPDIYVHSPDRHAAQFIAQMLLREAPRAKTVGVEMGAYYYTAR 132
Query: 104 DLKEKGKISE---FKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKE 160
D E K FK + ++ +R +KS+ EI + +A I ++ + A+E G ++
Sbjct: 133 DHAELQKALPNVAFKDAELLVNWVRFIKSEREIAYMREAGVITERMMKRAVEVAAPGVRQ 192
Query: 161 REIAAKVEYLMKMNGAEK----PAFDTI-IASGYRSALPHGVASDKRIEKGDLVVIDLGA 215
++AA + Y +M+G E PA + G R+ PH + +D+RI+ + I+L
Sbjct: 193 CDVAAAI-YHAQMSGTENYGGLPATSPPHMGFGERAREPHPIFTDRRIDTNSVANIELSG 251
Query: 216 LYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEY 275
Y++ ++RTV G P + R++ V+EA + +++A RPG+T + ++ R + +
Sbjct: 252 CRLRYHAPMSRTVYFGRPPQSYRDLASYVIEAVETSLDAVRPGVTCEGIELAWRKSMSAH 311
Query: 276 GYGDYFIHSLGHGVGLEI-----HEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIE 330
G + LG+ +G+ + + D TVL+ G + G+++ G+ I
Sbjct: 312 GIEKE--NRLGYSIGIAYTPTWGERTASIRRTDLTVLEPGAAFHLMGGLWLAN-TGITIT 368
Query: 331 DTIVITKTGARRLTKTERELI 351
+ V+T TG LT T REL+
Sbjct: 369 QSFVVTATGHEPLTATPRELV 389
>emb|CAA75230.1| (Y14996) prolidase [Suberites domuncula]
Length = 501
Score = 106 bits (263), Expect = 3e-22
Identities = 100/389 (25%), Positives = 167/389 (42%), Gaps = 83/389 (21%)
Query: 43 GYILVNNDGATLYVPELEYEMAKEESKI-PVEKFKRRDDFYKVFEGVKVLGIEGSLSYSF 101
G + V+ AT+++P L + A +I E F+++ D + V ++ + S S
Sbjct: 91 GILEVDTGKATVFIPRLPEDYATWMGQIYSCEHFRKKYDIHSVRYTDEITEVIKSADPSM 150
Query: 102 V-------------------EDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEI 142
+ E + + I K + +I E R++K+ E+ ++ ++
Sbjct: 151 LLTLMGLNTDSNKFCKEACFEGIGDFQAIINNKLLHPIIMECRVIKTPLEVAVLRYTNQV 210
Query: 143 ADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP-AFDTIIASGYRSALPH----GV 197
+ A + V G KE ++ + ++ NG + ++ I SG+ A H G
Sbjct: 211 SSAAHCEVMRSVKPGIKEYQMESLFKHYCYANGGMRHVSYTCICGSGHNGATLHYGHAGE 270
Query: 198 ASDKRIEKGDLVVIDLGALYNHYNSDITRTV-VVGSPNEKQREIYEIVLEAQKKAVEAAR 256
+ K IE GD+ + D+G Y Y SDIT + V G E Q+ +Y VL+A + ++A +
Sbjct: 271 PNAKTIENGDMCLFDMGGEYCCYTSDITCSFPVSGKFTEDQKIVYNAVLKANRAVMDAMK 330
Query: 257 PGITTKELDSIARNI----IKEYGY--GD------------YFIHSLGHGVGLEIHE--- 295
PG+ ++ +A + +KE G GD + H LGH +G + H+
Sbjct: 331 PGVCWVDMHKLADKVHLEQLKEAGLLKGDVEEMMKVHLGAVFMPHGLGHFMGCDTHDVGG 390
Query: 296 WP-GVSQYDE---------TVLKEGMVITIEPGIY------------------------- 320
+P GV + D L+EGM IT+EPGIY
Sbjct: 391 YPEGVVRVDSPGLRSLRTARTLQEGMCITVEPGIYFIDHLINKALLEPTQSCFINRDMLA 450
Query: 321 -IPKFGGVRIEDTIVITKTGARRLTKTER 348
+ GGVRIED +V+T TG LT R
Sbjct: 451 RFRRTGGVRIEDDVVVTATGVELLTVVPR 479
>gi|6320922 Yer078cp [Saccharomyces cerevisiae] >gi|731481|sp|P40051|YEQ8_YEAST
HYPOTHETICAL 58.0 KD PEPTIDASE IN PTP3-ILV1 INTERGENIC
REGION >gi|1077673|pir||S50581 hypothetical protein
YER078c - yeast (Saccharomyces cerevisiae)
>gi|603316|gb|AAB64633.1| (U18839) Yer078cp
[Saccharomyces cerevisiae]
Length = 511
Score = 105 bits (260), Expect = 7e-22
Identities = 71/254 (27%), Positives = 126/254 (48%), Gaps = 28/254 (11%)
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
K + I E R +KS +E++I+ +A +I+ ++ A + + ER + + + Y
Sbjct: 232 KPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAFAK--RFRNERTLDSFLHYKFISG 289
Query: 175 GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRT-VVVGSP 233
G +K A+ ++A+G S H +D + ++V++D Y +DI+RT G
Sbjct: 290 GCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTWPNSGKF 349
Query: 234 NEKQREIYEIVLEAQKKAVEAARPG--------------ITTKELDSIARNIIKEYGYGD 279
+ QR++YE VL Q+ ++ + + +EL ++ + + +
Sbjct: 350 TDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDKVSGWNVEK 409
Query: 280 YFIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIP---------KFGGVRIE 330
+ H +GH +GL++H+ P VS+Y+ LK G VITIEPG+YIP + G+RIE
Sbjct: 410 LYPHYIGHNLGLDVHDVPKVSRYEP--LKVGQVITIEPGLYIPNEESFPSYFRNVGIRIE 467
Query: 331 DTIVITKTGARRLT 344
D I I + LT
Sbjct: 468 DDIAIGEDTYTNLT 481
>gb|AAF54806.1| (AE003695) CG5663 gene product [Drosophila melanogaster]
Length = 483
Score = 104 bits (258), Expect = 1e-21
Identities = 79/293 (26%), Positives = 129/293 (43%), Gaps = 64/293 (21%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAK-VEYLMKMNGAEK 178
++ E R++KS EEI+++ +++ A + + + G+ E E + + + + G
Sbjct: 182 ILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRH 241
Query: 179 PAFDTIIASGYRSALPH----GVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSP 233
++ I SG S++ H G + K ++ GDL + D+GA Y Y +DIT T G
Sbjct: 242 ASYTCICGSGTNSSILHYGHAGAPNSKPVQDGDLCLFDMGANYCGYAADITCTFPANGKF 301
Query: 234 NEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNI----IKEYGY------------ 277
+ Q+ IY VL+A+ E+AR G++ ++ +A + +KE G
Sbjct: 302 TDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGGMLKGDVEEMLEAG 361
Query: 278 --GDYFIHSLGHGVGLEIHEWPGVSQYD--------------ETVLKEGMVITIEPGIY- 320
G + H LGH +GL++H+ G + +LK GM +TIEPG Y
Sbjct: 362 VSGVFQPHGLGHLIGLDVHDVGGYLPKEPKRPSEPWLSKLRFARILKAGMYVTIEPGCYF 421
Query: 321 -------------------------IPKFGGVRIEDTIVITKTGARRLTKTER 348
FGGVRIED ++ITKTG R
Sbjct: 422 INWLMDRALADPNIAKFINAEMFNRFRNFGGVRIEDDVLITKTGVENFAIVPR 474
>sp|P38487|CREA_BACSP CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|2126824|pir||I39809
creatinase (EC 3.5.3.3) - Bacillus sp
>gi|500611|dbj|BAA03358.1| (D14463) creatinase [Bacillus
sp.] >gi|1097201|prf||2113324A creatinase [Bacillus sp.]
Length = 411
Score = 104 bits (258), Expect = 1e-21
Identities = 99/377 (26%), Positives = 170/377 (44%), Gaps = 41/377 (10%)
Query: 4 MDEKIKRIIEFMNENSIDAVLITKNPNIYYLSG---ASPLAGGYILVNNDGATLYVPELE 60
M + R+ E+M + IDAV+ T NI Y S S ++V D ++
Sbjct: 29 MTRRNTRLREYMAKAGIDAVMFTSYHNINYYSDFLYTSFNRSYALVVTQDKHVTVSANID 88
Query: 61 YEMAKEES---KIPVEKFKRRDDFYKVFEGVKV-------LGIEGS-LSYSFVEDLKEKG 109
M S I +KR + Y V + + LG+E ++ +++
Sbjct: 89 AGMPWRRSFDENIVYTDWKRDNFLYAVKKVLNEGGFSSGRLGVENDHMTLDLRRQVQDAL 148
Query: 110 KISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAK-VE 168
+E V + R+ KSDEEI +I+ IAD A +E + EG E E+A E
Sbjct: 149 PNTELVDVSQAVMGHRMFKSDEEIDLIKNGARIADIGGAAVVEAIREGVPEYEVALHGTE 208
Query: 169 YLMKMNGAEKPAF---DTII--ASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSD 223
+++ P DT I SG + H A+ +++++GD++ ++ + Y +
Sbjct: 209 AMVREIARTYPHAELRDTWIWFQSGINTDGAHNWATSRKLQRGDILSLNCFPMIAGYYTA 268
Query: 224 ITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKE--------Y 275
+ RT+ + +++ E++EI + ++ +E +PG ++ + I +E +
Sbjct: 269 LERTLFLEEVSDRHLELWEINCKVHRRGLELIKPGARCMDIAAELNEIYREHDLLANRTF 328
Query: 276 GYGDYF---IHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPK----FGGVR 328
GYG F H G GLE+ E ETVL+ GMV+++EP I IP+ GG R
Sbjct: 329 GYGHSFGVLSHYYGREAGLELRE------DIETVLEPGMVVSMEPMIMIPEGEPGAGGYR 382
Query: 329 IEDTIVITKTGARRLTK 345
D +VI++ G +TK
Sbjct: 383 EHDILVISENGTENITK 399
>pir||T44250 creatinase (EC 3.5.3.3) [validated] - Arthrobacter sp. (strain
TE1826) >gi|3116223|dbj|BAA25928.1| (AB007122)
creatinase [Arthrobacter sp.]
Length = 411
Score = 104 bits (257), Expect = 2e-21
Identities = 101/373 (27%), Positives = 171/373 (45%), Gaps = 45/373 (12%)
Query: 4 MDEKIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAG----GYILVNNDGATLYVP-- 57
MD + + +M E IDAVL T NI Y S + G ++ N T+
Sbjct: 28 MDRRNTNLRNYMAEKDIDAVLFTSYHNINYYSDFLYTSFNRNYGLVVTQNKHVTVSANID 87
Query: 58 -ELEYEMAKEESKIPVEKFKRRDDFY----KVFE--GVKV--LGIEGS-LSYSFVEDLKE 107
+ + + +E+ + + RRD+++ KV E GVK LGIE +S + +
Sbjct: 88 GGMPWRRSYDENIVYTDW--RRDNYFYAIQKVLEEAGVKKARLGIEEDHVSIDLLRKFSD 145
Query: 108 KGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKV 167
E V + + R++KS EEI+ I+ IAD A +E + EG E E+A
Sbjct: 146 TFPNFELVHVSQDVMKQRMIKSAEEIRHIKNGARIADIGGYAVVEAIQEGVPEYEVALAG 205
Query: 168 EYLMKMNGA----EKPAFDTII--ASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYN 221
M A + DT + +G + H A+ K+++KG+++ ++ + Y
Sbjct: 206 SKAMTREIAKLYPQSELRDTWVWFQAGINTDGAHSWATSKKVQKGEILSLNTFPMIAGYY 265
Query: 222 SDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKE------- 274
+ + RT+ + ++ + +EI +E K+ +E +PG K++ + + +E
Sbjct: 266 TALERTLFLEEVSDAHLKYWEINVEVHKRGLELIKPGAVCKDICAELNEMFREHDLVKNR 325
Query: 275 -YGYGDYF---IHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPK----FGG 326
+GYG F H G GLE+ E +T+L+ GMVI++EP I IP+ GG
Sbjct: 326 TFGYGHSFGVLSHYYGREAGLELRE------DIDTILEPGMVISMEPMILIPEGQPGAGG 379
Query: 327 VRIEDTIVITKTG 339
R D +VI + G
Sbjct: 380 YREHDILVIQENG 392
>gi|11425821 Xaa-Pro dipeptidase [Homo sapiens]
Length = 493
Score = 103 bits (254), Expect = 3e-21
Identities = 108/388 (27%), Positives = 170/388 (42%), Gaps = 83/388 (21%)
Query: 43 GYILVNNDGATLYVPELEYEMAKEESKI-PVEKFKRR---DDFYKVFEGVKVLGIE---- 94
G I V+ +TL+VP L A KI E FK + DD V E VL +
Sbjct: 84 GVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSV 143
Query: 95 -------GSLSYSFVEDLKEKGKISEFKKVDDV----IKEMRIVKSDEEIKIIEKACEIA 143
+ S S + G IS+F+ + + I E R+ K+D E++++ +I+
Sbjct: 144 LLTLRGVNTDSGSVCREASFDG-ISKFEVNNTILHPEIVESRVFKTDMELEVLRYTNKIS 202
Query: 144 DKAVMAAIEEVTEGKKEREIAAKVE-YLMKMNGAEKPAFDTIIASGYRSALPH----GVA 198
+A ++ V G KE E+ + E Y G ++ I SG SA+ H G
Sbjct: 203 SEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAP 262
Query: 199 SDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNEKQREIYEIVLEAQKKAVEAARP 257
+D+ I+ GD+ + D+G Y + SDIT + G Q+ +YE VL + + + A +P
Sbjct: 263 NDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKP 322
Query: 258 GITTKELDSIARNI-IKEYGY----------------GDYFI-HSLGHGVGLEIHE---W 296
G ++ +A I ++E + G F+ H LGH +G+++H+ +
Sbjct: 323 GDWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGY 382
Query: 297 P-GVSQYDETVLKE---------GMVITIEPGIY-------------------------- 320
P GV + DE L+ GMV+T+EPGIY
Sbjct: 383 PEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQR 442
Query: 321 IPKFGGVRIEDTIVITKTGARRLTKTER 348
FGGVRIE+ +V+T +G LT R
Sbjct: 443 FRGFGGVRIEEDVVVTDSGIELLTCVPR 470
>sp|Q05813|AMP1_STRLI XAA-PRO AMINOPEPTIDASE I (X-PRO AMINOPEPTIDASE I) (AMINOPEPTIDASE P
I) (APP) (PEPP I) (AMINOACYLPROLINE AMINOPEPTIDASE I)
>gi|484336|pir||JN0491 X-Pro aminopeptidase (EC
3.4.11.9) - Streptomyces lividans
>gi|295167|gb|AAA26703.1| (M91546) peptidase P
[Streptomyces lividans]
Length = 491
Score = 103 bits (254), Expect = 3e-21
Identities = 75/287 (26%), Positives = 141/287 (48%), Gaps = 43/287 (14%)
Query: 92 GIEGSLSYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAI 151
GIE +L+ + E+ ++ + E R+VK + EI ++KA + + +
Sbjct: 195 GIEAALTDKVTAERDEELRV--------FLSEARLVKDEFEIGELQKAVDSTVRGFEDVV 246
Query: 152 EEV--TEGKKEREIAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLV 209
+ + E ER I ++ G + + +I A+G + H V +D + GDL+
Sbjct: 247 KVLDRAEATSERYIEGTFFLRARVEGNDV-GYGSICAAGPHACTLHWVRNDGPVRSGDLL 305
Query: 210 VIDLGA-LYNHYNSDITRTVVV-GSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSI 267
++D G + +Y +D+TRT+ + G+ +E Q++IY+ V +AQ+ + A RPG ++
Sbjct: 306 LLDAGVETHTYYTADVTRTLPISGTYSELQKKIYDAVYDAQEAGIAAVRPGAKYRDFHDA 365
Query: 268 ARNIIK----EYGYGD--------------YFIHSLGHGVGLEIHEWPG--VSQYDETVL 307
++ ++ E+G + + +H GH +G+++H+ V Y + L
Sbjct: 366 SQRVLAERLVEWGLVEGPVERVLELGLQRRWTLHGTGHMLGMDVHDCAAARVESYVDGTL 425
Query: 308 KEGMVITIEPGIYIP----------KFGGVRIEDTIVITKTGARRLT 344
+ GMV+T+EPG+Y + GVRIED I++T G R L+
Sbjct: 426 EPGMVLTVEPGLYFQADDLTVPEEYRGIGVRIEDDILVTADGNRNLS 472
>sp|Q10439|YDE5_SCHPO PROBABLE 55.1 KDA PEPTIDASE C12B10.05 >gi|7492718|pir||T37572
probable metalloproteinase - fission yeast
(Schizosaccharomyces pombe) >gi|4008582|emb|CAA94695.1|
(Z70721) putative metallopeptidase [Schizosaccharomyces
pombe]
Length = 486
Score = 102 bits (252), Expect = 6e-21
Identities = 87/337 (25%), Positives = 157/337 (45%), Gaps = 37/337 (10%)
Query: 24 LITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKEESKIPVEKFKRRDDFYK 83
L +KNP I G L G L G L+ E Y+ + S I K FY
Sbjct: 138 LPSKNPYIEKWEG---LRTGSTL----GKKLFQIENVYDSSLASSVINALGKKSNRIFYN 190
Query: 84 VFEGVKVLGIEGSLSYSFVED-LKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEI 142
G + + + + F++D L + + S + VD+++ +R +KS E++ +++A I
Sbjct: 191 YQTGY-LSKMPAASAPEFIQDTLTKLFRTSTQRSVDELLHPLRSIKSTAELECMKEAANI 249
Query: 143 ADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKR 202
+ + + E KE E++A+ Y + G ++ A+ ++A G H ++
Sbjct: 250 SSNVYREIMRKRFE--KEAEMSAEFNYRFCIGGCDRSAYVPVVAGGKNGLTIHYTINNDI 307
Query: 203 IEKGDLVVIDLGALYNHYNSDITRT-VVVGSPNEKQREIYEIVLEAQKKAVEAARPG--- 258
++V++D G + Y +DI+RT + G + QR++Y+ VL QKK ++
Sbjct: 308 FRPDEMVLVDAGGEFGGYVTDISRTWPINGKFSTVQRDLYQAVLNVQKKCIKYCCTSNGW 367
Query: 259 -----------ITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYDETVL 307
+ +EL + + K + HS+GH +GLEIH+ + Y L
Sbjct: 368 SLADIHFESVKLMHEELKQVGIHGTKREITDILYPHSIGHEIGLEIHDCSTNNGYQP--L 425
Query: 308 KEGMVITIEPGIYIPKFGG---------VRIEDTIVI 335
++ VITIEPG+Y+P+ G +RIED++++
Sbjct: 426 RKNQVITIEPGLYVPEEDGWPQWAQGIAIRIEDSVIV 462
>pir||S72196 X-Pro dipeptidase (EC 3.4.13.9) - mouse
Length = 493
Score = 102 bits (251), Expect = 8e-21
Identities = 112/421 (26%), Positives = 179/421 (41%), Gaps = 87/421 (20%)
Query: 13 EFMNENSIDAVLITKNPNIYYLSGASPLAG--GYILVNNDGATLYVPELEYEMAKEESKI 70
E M D +I + + ++ + +G G I V+ +TL+VP L A KI
Sbjct: 52 EEMERYCTDTSIIFRQESFFHWAFGVVESGCYGVIDVDTGKSTLFVPRLPDSYATWMGKI 111
Query: 71 -PVEKFKRR---DDFYKVFEGVKVL------------GIEGSLSYSFVEDLKEKGKISEF 114
E FK + DD E VL G+ S S + +G IS+F
Sbjct: 112 HSKEYFKEKYAVDDVQYTDEIASVLTSRNPSVLLTLRGVNTD-SGSVCREASFEG-ISKF 169
Query: 115 KKVDDV----IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVE-Y 169
+ + I E R+ K+D E++++ I+ +A ++ V G KE E+ + + Y
Sbjct: 170 NVNNTILHPEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHY 229
Query: 170 LMKMNGAEKPAFDTIIASGYRSALPH----GVASDKRIEKGDLVVIDLGALYNHYNSDIT 225
G ++ I SG +A+ H G +D+ I+ GD+ + D+G Y + SDIT
Sbjct: 230 CYSRGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDIT 289
Query: 226 RTVVV-GSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNI------------- 271
+ G E Q+ IYE VL + + + +PG+ ++ +A I
Sbjct: 290 CSFPANGKFTEDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELARIGLLSC 349
Query: 272 ----IKEYGYGDYFI-HSLGHGVGLEIHE---WP-GVSQYDETVLKE---------GMVI 313
+ + G F+ H LGH +GL++H+ +P GV + DE L+ GMV+
Sbjct: 350 SVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGVERIDEPGLRSLRTARHLEPGMVL 409
Query: 314 TIEPGIY--------------------------IPKFGGVRIEDTIVITKTGARRLTKTE 347
T+EPGIY FGGVRIE+ +V+T +G LT
Sbjct: 410 TVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLTCVP 469
Query: 348 R 348
R
Sbjct: 470 R 470
>dbj|BAB11685.1| (D82983) prolidase [Mus musculus]
Length = 493
Score = 102 bits (251), Expect = 8e-21
Identities = 112/421 (26%), Positives = 179/421 (41%), Gaps = 87/421 (20%)
Query: 13 EFMNENSIDAVLITKNPNIYYLSGASPLAG--GYILVNNDGATLYVPELEYEMAKEESKI 70
E M D +I + + ++ + +G G I V+ +TL+VP L A KI
Sbjct: 52 EEMQRYCTDTSIIFRQESFFHWAFGVVESGCYGVIDVDTGKSTLFVPRLPDSYATWMGKI 111
Query: 71 -PVEKFKRR---DDFYKVFEGVKVL------------GIEGSLSYSFVEDLKEKGKISEF 114
E FK + DD E VL G+ S S + +G IS+F
Sbjct: 112 HSKEYFKEKYAVDDVQYTDEIASVLTSRNPSVLLTLRGVNTD-SGSVCREASFEG-ISKF 169
Query: 115 KKVDDV----IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVE-Y 169
+ + I E R+ K+D E++++ I+ +A ++ V G KE E+ + + Y
Sbjct: 170 NVNNTILHPEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHY 229
Query: 170 LMKMNGAEKPAFDTIIASGYRSALPH----GVASDKRIEKGDLVVIDLGALYNHYNSDIT 225
G ++ I SG +A+ H G +D+ I+ GD+ + D+G Y + SDIT
Sbjct: 230 CYSRGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDIT 289
Query: 226 RTVVV-GSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNI------------- 271
+ G E Q+ IYE VL + + + +PG+ ++ +A I
Sbjct: 290 CSFPANGKFTEDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELARIGLLSC 349
Query: 272 ----IKEYGYGDYFI-HSLGHGVGLEIHE---WP-GVSQYDETVLKE---------GMVI 313
+ + G F+ H LGH +GL++H+ +P GV + DE L+ GMV+
Sbjct: 350 SVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGVERIDEPGLRSLRTARHLEPGMVL 409
Query: 314 TIEPGIY--------------------------IPKFGGVRIEDTIVITKTGARRLTKTE 347
T+EPGIY FGGVRIE+ +V+T +G LT
Sbjct: 410 TVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLTCVP 469
Query: 348 R 348
R
Sbjct: 470 R 470
>pir||E81084 aminopeptidase, probable NMB1428 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226668|gb|AAF41789.1| (AE002492) aminopeptidase,
putative [Neisseria meningitidis MC58]
Length = 598
Score = 101 bits (250), Expect = 1e-20
Identities = 102/357 (28%), Positives = 159/357 (43%), Gaps = 39/357 (10%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGA-------SPLAGGYILVNNDGATLYVPE 58
EK+ R+ M E D L++ +I +L+ +P+ ++L+ D A L+
Sbjct: 171 EKLARVRAVMAEKGADYHLVSSLDDIAWLTNLRGSDVPFNPVFVSFLLIGKDNAVLFTDR 230
Query: 59 L----EYEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEF 114
E A + + I VE + + D GV ++ + S + L E ++ E
Sbjct: 231 CRLNAEAAAALQTAGIAVEPYAQVADKLAQIGGVLLIE-PNKTAVSTLVRLPESVRLIEG 289
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTE--GKKEREIAAKVEYLMK 172
+ K KS+ +I I +A E A+ E + G V+ ++
Sbjct: 290 INPSTLFKSC---KSEADIARIREAMEHDGAALCGFFAEFEDIIGNGGSLTEIDVDTMLY 346
Query: 173 MNGAEKP-----AFDTIIASGYRSALPHGVA---SDKRIEKGDLVVIDLGALYNHYNSDI 224
+ + +P +FDTI ALPH A S I L++ID GA Y +DI
Sbjct: 347 RHRSVRPGFISLSFDTIAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGGTTDI 406
Query: 225 TRTVVVGSPNEKQREIYEIVLEAQKKAVEAARP-GITTKELDSIARNII--KEYGYGDYF 281
TR V VG+P+ +Q+ +VL+A EA P I + +D+I R + + YG
Sbjct: 407 TRVVPVGTPSAEQKSDNTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDYG--- 463
Query: 282 IHSLGHGVG--LEIHEWP-----GVSQYDETVLKEGMVITIEPGIYIPKFGGVRIED 331
H GHGVG L +HE P ET +K+GMV +IEPG+Y P G+RIE+
Sbjct: 464 -HGTGHGVGYFLNVHEGPQRIAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIEN 519
>sp|O84859|AMPM_CHLTR METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435565|pir||D71462 probable methionine
aminopeptidase - Chlamydia trachomatis (serotype D,
strain UW3/Cx) >gi|3329324|gb|AAC68448.1| (AE001358)
Methionine Aminopeptidase [Chlamydia trachomatis]
Length = 291
Score = 101 bits (249), Expect = 1e-20
Identities = 63/213 (29%), Positives = 105/213 (48%), Gaps = 15/213 (7%)
Query: 126 IVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA-------EK 178
I+K+ E+I+ I KAC++ + A E EG E+ L K + A
Sbjct: 42 IIKTPEQIEKIRKACQVTAHILDALCEAAKEGVTTNELDLLSRELHKRHNAIPAPLNYGH 101
Query: 179 PAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQR 238
P F I + + HG+ +D ++ GD++ ID+ + + + D +R V++G +E +R
Sbjct: 102 PPFPKTICTSLNEVICHGIPNDIPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVSEIKR 161
Query: 239 EIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYG--DYFIHSLGHGVGLEIHEW 296
++ E LEA A+ P + E+ + N +YG+ D F+ GHGVG++ HE
Sbjct: 162 KVCEASLEALNAAISILEPNLPLYEIGEVIENCAAKYGFSVVDQFV---GHGVGVKFHEN 218
Query: 297 PGVSQYDETV---LKEGMVITIEPGIYIPKFGG 326
P V+ + + L GM+ TIEP I + K G
Sbjct: 219 PFVAHHRNSCKIPLAPGMIFTIEPMINVGKKEG 251
>pir||D81858 probable aminopeptidase NMA1640 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7380282|emb|CAB84868.1|
(AL162756) putative aminopeptidase [Neisseria
meningitidis Z2491]
Length = 659
Score = 101 bits (249), Expect = 1e-20
Identities = 102/357 (28%), Positives = 157/357 (43%), Gaps = 39/357 (10%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGA-------SPLAGGYILVNNDGATLYVPE 58
EK+ R+ M E D L++ +I +L+ +P+ Y+L+ D A L+
Sbjct: 232 EKLARVRAVMAEKGADYHLVSSLDDIAWLTNLRGSDVPFNPVFVSYLLIGKDNAVLFTDR 291
Query: 59 L----EYEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEF 114
E A + + I VE + + D G ++ + S + L E ++ E
Sbjct: 292 CRLNAEAAAALQTAGITVEPYAQVADKLAQIGGALLIE-PNKTAVSTLVRLPESVRLIEG 350
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTE--GKKEREIAAKVEYLMK 172
+ K KS+ +I I +A E A+ E + G V+ ++
Sbjct: 351 INPSTLFKSC---KSEADIARIREAMEHDGAALCGFFAEFEDIIGNGGSLTEIDVDTMLY 407
Query: 173 MNGAEKP-----AFDTIIASGYRSALPHGVA---SDKRIEKGDLVVIDLGALYNHYNSDI 224
+ + +P +FDTI ALPH A S I L++ID GA Y +DI
Sbjct: 408 RHRSVRPGFISLSFDTIAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGGTTDI 467
Query: 225 TRTVVVGSPNEKQREIYEIVLEAQKKAVEAARP-GITTKELDSIARNII--KEYGYGDYF 281
TR V VG+P +Q+ +VL+A EA P I + +D+I R + + YG
Sbjct: 468 TRVVPVGTPTAEQKRDNTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDYG--- 524
Query: 282 IHSLGHGVG--LEIHEWP-----GVSQYDETVLKEGMVITIEPGIYIPKFGGVRIED 331
H GHGVG L +HE P ET +K+GMV +IEPG+Y P G+RIE+
Sbjct: 525 -HGTGHGVGYFLNVHEGPQRIAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIEN 580
>gi|6679279 peptidase 4 [Mus musculus] >gi|1709633|sp|Q11136|PEPD_MOUSE XAA-PRO
DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE) (PEPTIDASE 4)
>gi|1236706|gb|AAA92975.1| (U51014) prolidase [Mus
musculus]
Length = 493
Score = 100 bits (247), Expect = 2e-20
Identities = 111/421 (26%), Positives = 178/421 (41%), Gaps = 87/421 (20%)
Query: 13 EFMNENSIDAVLITKNPNIYYLSGASPLAG--GYILVNNDGATLYVPELEYEMAKEESKI 70
E M D +I + + ++ + +G G I V+ +TL+VP L A KI
Sbjct: 52 EEMQRYCTDTSIIFRQESFFHWAFGVVESGCYGVIDVDTGKSTLFVPRLPDSYATWMGKI 111
Query: 71 -PVEKFKRR---DDFYKVFEGVKVL------------GIEGSLSYSFVEDLKEKGKISEF 114
E FK + DD E VL G+ S S + +G IS+F
Sbjct: 112 HSKEYFKEKYAVDDVQYTDEIASVLTSRNPSVLLTLRGVNTD-SGSVCREASFEG-ISKF 169
Query: 115 KKVDDV----IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVE-Y 169
+ + I E R+ K+D E++++ I+ +A ++ V G KE E+ + + Y
Sbjct: 170 NVNNTILHPEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHY 229
Query: 170 LMKMNGAEKPAFDTIIASGYRSALPH----GVASDKRIEKGDLVVIDLGALYNHYNSDIT 225
G ++ I SG +A+ H G +D+ I+ GD+ + D+G Y + SDIT
Sbjct: 230 CYSRGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDIT 289
Query: 226 RTVVVGSP-NEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNI------------- 271
+ E Q+ IYE VL + + + +PG+ ++ +A I
Sbjct: 290 CSFPANRKFTEDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELARIGLLSG 349
Query: 272 ----IKEYGYGDYFI-HSLGHGVGLEIHE---WP-GVSQYDETVLKE---------GMVI 313
+ + G F+ H LGH +GL++H+ +P GV + DE L+ GMV+
Sbjct: 350 SVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGVERIDEPGLRSLRTARHLEPGMVL 409
Query: 314 TIEPGIY--------------------------IPKFGGVRIEDTIVITKTGARRLTKTE 347
T+EPGIY FGGVRIE+ +V+T +G LT
Sbjct: 410 TVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLTCVP 469
Query: 348 R 348
R
Sbjct: 470 R 470
>gi|4557835 Xaa-Pro dipeptidase; prolidase; Peptidase D (prolidase); proline
dipeptidase [Homo sapiens]
>gi|129800|sp|P12955|PEPD_HUMAN XAA-PRO DIPEPTIDASE
(X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE) (PROLIDASE)
(IMIDODIPEPTIDASE) >gi|189842|gb|AAA60064.1| (J04605)
prolidase [Homo sapiens]
Length = 493
Score = 97.9 bits (240), Expect = 2e-19
Identities = 107/388 (27%), Positives = 168/388 (42%), Gaps = 83/388 (21%)
Query: 43 GYILVNNDGATLYVPELEYEMAKEESKI-PVEKFKRR---DDFYKVFEGVKVLGIE---- 94
G I V+ +TL+VP L A KI E FK + DD V E VL +
Sbjct: 84 GVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSV 143
Query: 95 -------GSLSYSFVEDLKEKGKISEFKKVDDV----IKEMRIVKSDEEIKIIEKACEIA 143
+ S S + G IS+F+ + + I E R+ K+D E++++ +I+
Sbjct: 144 LLTLRGVNTDSGSVCREASFDG-ISKFEVNNTILHPEIVESRVFKTDMELEVLRYTNKIS 202
Query: 144 DKAVMAAIEEVTEGKKEREIAAKVE-YLMKMNGAEKPAFDTIIASGYRSALPH----GVA 198
+A ++ V G KE + + E Y G ++ I SG SA+ H G
Sbjct: 203 SEAHREVMKAVKVGMKEYGLESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAP 262
Query: 199 SDKRIEKGDLVVIDLGALYNHYNSDITRTVV-VGSPNEKQREIYEIVLEAQKKAVEAARP 257
+D+ I+ GD+ + D+G Y SDIT + G Q+ +YE VL + + + A +P
Sbjct: 263 NDRTIQNGDMCLFDMGGEYYSVASDITCSFPRNGKFTADQKAVYEAVLLSSRAVMGAMKP 322
Query: 258 GITTKELDSIARNI-IKEYGY----------------GDYFI-HSLGHGVGLEIHE---W 296
G ++D +A I ++E + G F+ H LGH +G+++H+ +
Sbjct: 323 GDWWPDIDRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGY 382
Query: 297 P-GVSQYDETVLKE---------GMVITIEPGIY-------------------------- 320
P GV + DE L+ GMV+T+EPGIY
Sbjct: 383 PEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQR 442
Query: 321 IPKFGGVRIEDTIVITKTGARRLTKTER 348
FGGVRIE+ +V+ +G LT R
Sbjct: 443 FRGFGGVRIEEDVVVIDSGIELLTCVPR 470
>pir||T47008 hypothetical protein [imported] - Yersinia pestis
>gi|4106596|emb|CAA21351.1| (AL031866) ORF28, len: 405
aa, similar to a proline peptidase protein in Bacillus
subtilis O31689, Fasta scores opt: 354, E(): 2.6e-15,
25.7% identity in 284 aa overlap, and Streptococcus
lactis O08316, Fasta scores: opt: 332, E(): 6.3e-14,
25.9% i>
Length = 405
Score = 97.9 bits (240), Expect = 2e-19
Identities = 98/384 (25%), Positives = 162/384 (41%), Gaps = 50/384 (13%)
Query: 15 MNENSIDAVLITKNPNIYYLSGASPL---------AGGYILVNNDGATLYVPELEYEMAK 65
M IDA+++T N YYL+G + A I+ + + E+E A
Sbjct: 20 MEREGIDALVVTVCDNFYYLTGFASFFMYTFRHTGAAVAIMFRDANIPSQIIMNEFEAAS 79
Query: 66 -------------------EESKIPVEKFKRRD-----DFYKVFEGVK-VLGIEGSLSYS 100
++ + P +K+RD VF VK L G L +
Sbjct: 80 THFDMPNSVLKTFPVWVDVDDPRNPHHHYKKRDRPIGPPVEAVFSLVKNALEDAGVLDKT 139
Query: 101 FVEDLKE-----KGKISE----FKKVDD--VIKEMRIVKSDEEIKIIEKACEIADKAVMA 149
+L+ KG + + K VD + E+R++KS EI+ + K+ EI + + +
Sbjct: 140 IAIELQAMSNGGKGVLDKVAPGLKLVDSTALFNEIRMIKSPWEIEHLRKSAEITEYGIAS 199
Query: 150 AIEEVTEGKKEREIAAKVEY-LMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDL 208
A +++ G E+ A + +M F+ I S P +A + GDL
Sbjct: 200 AAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLISVGDNFS--PKIIADTTPAKVGDL 257
Query: 209 VVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIA 268
+ D G Y +D+ RT V+G P++ ++IY+ + + + PG+ K +
Sbjct: 258 IKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDST 317
Query: 269 RNIIKEYGYGDYFIHSLGHGVG--LEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGG 326
+IK G Y LGHG G L + E P VS GMV+++E Y G
Sbjct: 318 MAVIKTSGLPHYNRGHLGHGDGVFLGLEEVPFVSTQATETFCPGMVLSLETPYYGIGVGS 377
Query: 327 VRIEDTIVITKTGARRLTKTEREL 350
+ +ED I+IT +G L+K +R+L
Sbjct: 378 IMLEDMILITDSGFEFLSKLDRDL 401
>sp|P27875|AGS_AGRRH AGROPINE SYNTHESIS CYCLASE >gi|77884|pir||JQ1051 agropine synthase
- Agrobacterium rhizogenes plasmid Ri
>gi|407085|emb|CAA35719.1| (X51338) cyclase
[Agrobacterium rhizogenes]
Length = 396
Score = 97.9 bits (240), Expect = 2e-19
Identities = 74/260 (28%), Positives = 127/260 (48%), Gaps = 19/260 (7%)
Query: 102 VEDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKER 161
VE +++ K V +++E+ K I I ++C+I + +A + G E
Sbjct: 131 VELVRQALGAEHIKDVTPMLQELWACKDAAGIAAIRQSCDIVREQFLACRNAIAPGIPEW 190
Query: 162 EIA-AKVEYLMKMNGA------EKPAFD----TIIASGY-RSALPHGVASDKRIEKGDLV 209
++ A V ++ NG E P F ++ SG R+A H + ++ G +
Sbjct: 191 KVTLASVTAAIERNGELLAEDEELPRFWPHQLNMVGSGADRTARCHPSGGGRIMQDGAIA 250
Query: 210 VIDL-GALYNHYNSDITRTVVVGSPN--EKQREIYEIVLEAQKKAVEAARPGITTKELDS 266
I L G + + + R V +GS R++ ++ EAQ A+ A RPG+T E+ +
Sbjct: 251 QICLCGQTFRGHAACFDRPVPIGSKPLPANLRKVIDVAREAQSAALAALRPGVTAGEIHA 310
Query: 267 IARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQY--DETVLKEGMVITIEPGIYIPKF 324
A +IK G+ F+H G G+G +W G+ +TVL+ G V++IEPG+Y+
Sbjct: 311 AAVAVIKRSGWEAPFLHRTGRGIGYS--DWDGIELKAGSQTVLEVGNVLSIEPGVYVQGI 368
Query: 325 GGVRIEDTIVITKTGARRLT 344
GG R DT+++++TG LT
Sbjct: 369 GGARFGDTVLVSETGYEVLT 388
>emb|CAC11625.1| (AL445064) proline dipeptidase related protein [Thermoplasma
acidophilum]
Length = 331
Score = 97.5 bits (239), Expect = 2e-19
Identities = 82/299 (27%), Positives = 135/299 (44%), Gaps = 23/299 (7%)
Query: 45 ILVNNDGATLYVPELEYEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVED 104
+L +DG+ L ++Y K+ +E RD F +F F +
Sbjct: 46 VLSYSDGSQLMGEVVKYLKDLNAKKVGMEYAVERDAF--IF---------------FYDL 88
Query: 105 LKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIA 164
K+ + E + D++ +++++K EI I KA E+ K A + V EG KE +IA
Sbjct: 89 FKKLNRNVEVVDITDILDDIKVIKDRYEIDYIMKAGEVTRKVAAALADLVREGMKETDIA 148
Query: 165 AKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDI 224
A+ Y++ G+E+P I +G + S I +V I L A ++ Y +
Sbjct: 149 AEAYYMLYKAGSEEPLI--YINAGPNPRVHSEPLSTVTIRNNSIVTITLDADFSRYYVNK 206
Query: 225 TRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHS 284
+ T+ +G+P + + + EAQK AVE RPG E+ K+Y Y +
Sbjct: 207 SLTIPIGNPGDTALNAIKCMDEAQKVAVENTRPGTKFIEVMEKLDETYKKYDMLRYRVIG 266
Query: 285 LGHGVGLEIHEWP--GVSQYDETV-LKEGMVITI-EPGIYIPKFGGVRIEDTIVITKTG 339
H VGL+ E P + D V +K MV+ + + IP G V+IE+T V+ +G
Sbjct: 267 YAHSVGLKPEEMPITTIVPKDRFVEVKPYMVLALGHAPLMIPGIGSVKIEETYVVDPSG 325
>emb|CAB62984.1| (AL035450) dJ1057D18.1 (novel protein similar to yeast and
bacterial PEPP (aminopeptidase P, aminoacylproline
aminopeptidase)) [Homo sapiens]
Length = 222
Score = 96.3 bits (236), Expect = 4e-19
Identities = 69/198 (34%), Positives = 105/198 (52%), Gaps = 30/198 (15%)
Query: 168 EYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRT 227
E+ + GA+ A+ ++A G RS H V +++ I+ G++V++D G + Y SDITRT
Sbjct: 2 EFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRT 61
Query: 228 -VVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNII----KEYGY----- 277
V G Q E+YE VLE Q+ + PG + + + S+ +I K+ G
Sbjct: 62 WPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIK 121
Query: 278 --------GDYFIHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIP------- 322
Y H +GH +G+++H+ P + + L+ GMVITIEPGIYIP
Sbjct: 122 ENNAFKAARKYCPHHVGHYLGMDVHDTPDMPR--SLPLQPGMVITIEPGIYIPEDDKDAP 179
Query: 323 -KFG--GVRIEDTIVITK 337
KF GVRIED +V+T+
Sbjct: 180 EKFRGLGVRIEDDVVVTQ 197
>pir||A32454 X-Pro dipeptidase (EC 3.4.13.9) - human
Length = 493
Score = 95.2 bits (233), Expect = 1e-18
Identities = 106/388 (27%), Positives = 167/388 (42%), Gaps = 83/388 (21%)
Query: 43 GYILVNNDGATLYVPELEYEMAKEESKI-PVEKFKRR---DDFYKVFEGVKVLGIE---- 94
G I V+ +TL+VP L A KI E FK + DD V E VL +
Sbjct: 84 GVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSV 143
Query: 95 -------GSLSYSFVEDLKEKGKISEFKKVDDV----IKEMRIVKSDEEIKIIEKACEIA 143
+ S S + G IS+F+ + + I E R+ K+D E++++ +I+
Sbjct: 144 LLTLRGVNTDSGSVCREASFDG-ISKFEVNNTILHPEIVESRVFKTDMELEVLRYTNKIS 202
Query: 144 DKAVMAAIEEVTEGKKEREIAAKVE-YLMKMNGAEKPAFDTIIASGYRSALPH----GVA 198
+A ++ V G KE + + E Y G ++ I SG SA+ H G
Sbjct: 203 SEAHREVMKAVKVGMKEYGLESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAP 262
Query: 199 SDKRIEKGDLVVIDLGALYNHYNSDITRTVV-VGSPNEKQREIYEIVLEAQKKAVEAARP 257
+D+ I+ GD+ + D+G Y SDIT + G Q+ +YE VL + + + A +P
Sbjct: 263 NDRTIQNGDMCLFDMGGEYYSVASDITCSFPRNGKFTADQKAVYEAVLLSSRAVMGAMKP 322
Query: 258 GITTKELDSIARNI-IKEYGY----------------GDYFI-HSLGHGVGLEIHE---W 296
G ++ +A I ++E + G F+ H LGH +G+++H+ +
Sbjct: 323 GDWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGY 382
Query: 297 P-GVSQYDETVLKE---------GMVITIEPGIY-------------------------- 320
P GV + DE L+ GMV+T+EPGIY
Sbjct: 383 PEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQR 442
Query: 321 IPKFGGVRIEDTIVITKTGARRLTKTER 348
FGGVRIE+ +V+ +G LT R
Sbjct: 443 FRGFGGVRIEEDVVVIDSGIELLTCVPR 470
>emb|CAA75231.1| (Y14997) prolidase [Suberites domuncula]
Length = 465
Score = 95.2 bits (233), Expect = 1e-18
Identities = 86/335 (25%), Positives = 150/335 (44%), Gaps = 57/335 (17%)
Query: 43 GYILVNNDGATLYVPELEYEMAKEESKI-PVEKFKRRDDFYKVFEGVKVLGIEGSLSYSF 101
G + V+ AT+++P L + A +I E F+++ D + V ++ + S S
Sbjct: 91 GILEVDTGKATVFIPRLPEDYATWMGQIYSCEHFRKKYDIHSVRYTDEITEVIKSADPSM 150
Query: 102 V-------------------EDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEI 142
+ E + + I K + +I E R++K+ E+ ++ ++
Sbjct: 151 LLTLMGLNTDSNKFCKEACFEGIGDFQAIINNKLLHPIIMECRVIKTPLEVAVLRYTNQV 210
Query: 143 ADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP-AFDTIIASGYRSALPH----GV 197
+ A + V G KE ++ + ++ NG + ++ I SG+ A H G
Sbjct: 211 SSAAHCEVMRSVKPGIKEYQMESLFKHYCYANGGMRHVSYTCICGSGHNGATLHYGHAGE 270
Query: 198 ASDKRIEKGDLVVIDLGALYNHYNSDITRTV-VVGSPNEKQREIYEIVLEAQKKAVEAAR 256
+ K IE GD+ + D+G Y Y SDIT + V G E Q+ +Y VL+A + ++A +
Sbjct: 271 PNAKTIENGDMCLFDMGGEYCCYTSDITCSFPVSGKFTEDQKIVYNAVLKANRAVMDAMK 330
Query: 257 PGITTKELDSIARNI----IKEYGY--GD------------YFIHSLGHGVGLEIHE--- 295
PG+ ++ +A + +KE G GD + H LGH +G + H+
Sbjct: 331 PGVCWVDMHKLADKVHLEQLKEAGLLKGDVEEMMKVHLGAVFMPHGLGHFMGCDTHDVGG 390
Query: 296 WP-GVSQYDE---------TVLKEGMVITIEPGIY 320
+P GV + D L+EGM IT+EPGIY
Sbjct: 391 YPEGVVRVDSPGLRSLRTARTLQEGMCITVEPGIY 425
>sp|Q60394|AMP2_STRLI XAA-PRO AMINOPEPTIDASE II (X-PRO AMINOPEPTIDASE II) (AMINOPEPTIDASE
P II) (APP) (PEPP II) (AMINOACYLPROLINE AMINOPEPTIDASE
II) >gi|487887|gb|AAB00325.1| (L23174) aminopeptidase P
[Streptomyces lividans] >gi|8977942|emb|CAB95809.1|
(AL359949) Xaa-Pro aminopeptidase II (EC 3.4.11.9)
[Streptomyces coelicolor A3(2)]
Length = 470
Score = 94.8 bits (232), Expect = 1e-18
Identities = 73/289 (25%), Positives = 138/289 (47%), Gaps = 41/289 (14%)
Query: 90 VLGIEGSLSYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMA 149
V GI+ +L + D + ++ +D + ++R+VK E+ + KA + +
Sbjct: 170 VRGIDPALEAAVTTDEERDAEL------EDALSDLRLVKDAWELGELRKAVDSTVRGFTD 223
Query: 150 AIEEVTEG--KKEREIAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEKGD 207
+ E++ ER + ++ G + TI A+G + + H +D + GD
Sbjct: 224 VVGELSRAVASSERWLEGTFFRRARLEG-NAVGYGTICAAGEHATIMHWTDNDGPVRPGD 282
Query: 208 LVVIDLGA-LYNHYNSDITRTVVV-GSPNEKQREIYEIVLEAQKKAVEAARPGITTKELD 265
L+++D G + Y +D+TRT+ + G+ QRE+Y+ V EAQ+ + +PG ++
Sbjct: 283 LLLLDAGVETRSLYTADVTRTLPISGTFTPLQREVYDAVYEAQEAGIATVKPGAAYRDFH 342
Query: 266 SIARNIIK----EYGYGD--------------YFIHSLGHGVGLEIHEW--PGVSQYDET 305
A+ + E+G+ + + + GH +GL++H+ +Y E
Sbjct: 343 EAAQRHLAARLVEWGFIEGPAERAYELGLQRRFTMAGTGHMLGLDVHDCARARTEEYVEG 402
Query: 306 VLKEGMVITIEPGIY-------IPKFG---GVRIEDTIVITKTGARRLT 344
VL+ GM +T+EPG+Y +P+ GVRIED +V+T+ G L+
Sbjct: 403 VLEPGMCLTVEPGLYFQADDLTVPEEWRGIGVRIEDDLVVTEDGHENLS 451
>pir||S69353 aminopeptidase P - pig >gi|994862|gb|AAB34314.1| aminopeptidase P,
AP-P [swine, kidney cortex, Peptide, 624 aa]
Length = 624
Score = 94.8 bits (232), Expect = 1e-18
Identities = 63/225 (28%), Positives = 109/225 (48%), Gaps = 17/225 (7%)
Query: 122 KEMRIVKSD---EEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEK 178
+E ++K+ + + +I + ++E + K+ E + E+
Sbjct: 333 REQALLKASHVRDAVAVIRYLAWLEKNVPTGTVDEFSGAKRVEEFRGEEEFF------SG 386
Query: 179 PAFDTIIASGYRSALPHGVASD---KRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNE 235
P+F+TI ASG +AL H + +++ ++ ++D G Y +DITRTV G+P+
Sbjct: 387 PSFETISASGLNAALAHYSPTKELHRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSA 446
Query: 236 KQREIYEIVLEAQKKAVEAARPGITT-KELDSIARNIIKEYGYGDYFIHSLGHGVG--LE 292
Q+E Y VL P T+ + +++ AR + + G + H GHG+G LE
Sbjct: 447 FQKEAYTRVLIGNIDLSRLVFPAATSGRVVEAFARKALWDVGLN--YGHGTGHGIGNFLE 504
Query: 293 IHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITK 337
+HEWP QY + EGM +IEPG Y G+R+ED ++ +
Sbjct: 505 VHEWPVGFQYGNIPMAEGMFTSIEPGYYQDGEFGIRLEDVALVVE 549
>pir||G81724 methionine aminopeptidase TC0240 [imported] - Chlamydia muridarum
(strain Nigg) >gi|7190280|gb|AAF39111.1| (AE002291)
methionine aminopeptidase [Chlamydia muridarum]
Length = 295
Score = 94.8 bits (232), Expect = 1e-18
Identities = 67/249 (26%), Positives = 113/249 (44%), Gaps = 33/249 (13%)
Query: 126 IVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA-------EK 178
I+K+ ++I+ I KAC++ + + A + EG E+ L K A +
Sbjct: 46 IIKTPDQIEKIRKACQVTARILDALCKAAKEGVTTNELDQLSCNLHKQYNAIPAPLNYGQ 105
Query: 179 PAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQR 238
P F I + + HG+ +D ++ GD++ ID+ + + + D +R V++G E ++
Sbjct: 106 PPFPKTICTSLNEVICHGIPNDTPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVPEIKK 165
Query: 239 EIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYG--DYFIHSLGHGVGLEIHEW 296
++ E LEA A+ P + E+ + N YG+ D F+ GHGVG+ HE
Sbjct: 166 KVCEASLEALNAAIAILEPNLPLYEIGEVIENCAARYGFSVVDQFV---GHGVGVRFHEN 222
Query: 297 PGVSQYDETV---LKEGMVITIEPGIYIPKFGG------------------VRIEDTIVI 335
P V+ + + L GM TIEP I + K G + E T++I
Sbjct: 223 PYVAHHRNSCKIPLAPGMTFTIEPMINVGKKEGFIDPTNHWEARTCDHQPSAQWEHTVLI 282
Query: 336 TKTGARRLT 344
T +G LT
Sbjct: 283 TDSGYEILT 291
>gi|10955029 ags [Agrobacterium tumefaciens] >gi|8572686|gb|AAF77132.1|
(AF242881) ags [Agrobacterium tumefaciens]
Length = 395
Score = 93.6 bits (229), Expect = 3e-18
Identities = 72/264 (27%), Positives = 128/264 (48%), Gaps = 19/264 (7%)
Query: 98 SYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEG 157
S S +E +K + V +++++ K E I I+++C+I M + ++ G
Sbjct: 126 SGSNLELIKRTFGAERVRDVTLLLQDLWACKDAEGIAAIKQSCDIVGHQFMECRQVISPG 185
Query: 158 KKE-REIAAKVEYLMKMNGA------EKPAF-----DTIIASGYRSALPHGVASDKRIEK 205
E R A V+ ++ N E P F + + + R+A H + ++
Sbjct: 186 TCEWRVTLASVQTAIERNSQLLGENEELPRFWPHQLNMVGSGANRTARCHTSGGGRIMQD 245
Query: 206 GDLVVIDL-GALYNHYNSDITRTVVVGSP--NEKQREIYEIVLEAQKKAVEAARPGITTK 262
G+ V + L G L+ + R + VGS + ++ + +AQ A+ A RPG+ +
Sbjct: 246 GEHVQVCLCGQLFRGHAVRFDRPLPVGSKPLSGDILKVIKTARDAQLAALSAIRPGVMAR 305
Query: 263 ELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD--ETVLKEGMVITIEPGIY 320
E+ + A ++ G+ D F+H G G+G +W G+ ET+LK G V+++EPGIY
Sbjct: 306 EVHAAAVAVVNRGGWTDPFLHRTGRGIGYS--DWDGIELKAGAETMLKVGNVLSVEPGIY 363
Query: 321 IPKFGGVRIEDTIVITKTGARRLT 344
+ GG R DT+++T+TG LT
Sbjct: 364 VEGIGGARFGDTVLVTETGYEALT 387
>pir||D81414 probable aminopeptidase Cj0653c [imported] - Campylobacter jejuni
(strain NCTC 11168) >gi|6968120|emb|CAB75289.1|
(AL139075) putative aminopeptidase [Campylobacter
jejuni]
Length = 596
Score = 92.8 bits (227), Expect = 5e-18
Identities = 96/362 (26%), Positives = 167/362 (45%), Gaps = 36/362 (9%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGA-------SPLAGGYILVNNDGATLYVPE 58
EK+ + + M + + LI+ +I +L+ +P+ ++L+ D A L+V +
Sbjct: 167 EKLALVRQKMKNLNATSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQ 226
Query: 59 LEYEMAKEESKIPVEKF--KRRDDFYKVFE---GVKVLGIEGSLSYSFVEDLKEKGKISE 113
+ ++ E K+ ++ F K D+ E +L ++ + L + KI +
Sbjct: 227 KKVN-SELEKKLNLDGFWLKNYDEIIMELEELANTNLLIEPSKMTALLINSLDKSVKIIQ 285
Query: 114 FKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKM 173
+K K+ +EI I+ A A+ + E K +E+ ++++ +K
Sbjct: 286 EINPSTHLKA---AKNTKEIAHIQDAMIEDGVALCKFFAWLEEAIKNKELISELDIDVKA 342
Query: 174 NGAE-------KPAFDTIIASGYRSALPHGVASDKR---IEKGDLVVIDLGALYNHYNSD 223
+ +F TI +A PH A+ + ++K L++ID G Y + +D
Sbjct: 343 SEFRAQSKYYISDSFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTTD 402
Query: 224 ITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARP-GITTKELDSIARNIIKEYGYGDYFI 282
ITR V +G N +Q Y +VL+A A P IT LD+I R + + +I
Sbjct: 403 ITRVVPIGKANAEQIHDYTLVLKAHIAISSAIFPKDITMPLLDAITRAPLWKEQID--YI 460
Query: 283 HSLGHGVG--LEIHEWPGVSQY-----DETVLKEGMVITIEPGIYIPKFGGVRIEDTIVI 335
H GHGVG L +HE P V Y ++T KEGM+ +IEPGIY G+R+E+ ++
Sbjct: 461 HGTGHGVGYFLNVHEGPQVLSYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLVIH 520
Query: 336 TK 337
TK
Sbjct: 521 TK 522
>pir||S72440 X-Pro aminopeptidase (EC 3.4.11.9) precursor - pig
>gi|1517942|gb|AAC48664.1| (U55039) aminopeptidase P
[Sus scrofa]
Length = 673
Score = 91.3 bits (223), Expect = 1e-17
Identities = 62/225 (27%), Positives = 108/225 (47%), Gaps = 17/225 (7%)
Query: 122 KEMRIVKSD---EEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEK 178
+E ++K+ + + +I + ++E + K+ E + E+
Sbjct: 359 REQALLKASHVRDAVAVIRYLAWLEKNVPTGTVDEFSGAKRVEEFRGEEEFF------SG 412
Query: 179 PAFDTIIASGYRSALPHGVASD---KRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNE 235
P+F+TI ASG +AL H + +++ ++ ++D G Y +DITRTV G+P+
Sbjct: 413 PSFETISASGLNAALAHYSPTKELHRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSA 472
Query: 236 KQREIYEIVLEAQKKAVEAARPGITT-KELDSIARNIIKEYGYGDYFIHSLGHGVG--LE 292
Q+E Y VL P T+ + +++ AR + + G + H GHG+G L
Sbjct: 473 FQKEAYTRVLIGNIDLSRLVFPAATSGRVVEAFARKALWDVGLN--YGHGTGHGIGNFLC 530
Query: 293 IHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITK 337
+HEWP QY + EGM +IEPG Y G+R+ED ++ +
Sbjct: 531 VHEWPVGFQYGNIPMAEGMFTSIEPGYYQDGEFGIRLEDVALVVE 575
>pir||F72247 methionine aminopeptidase - Thermotoga maritima (strain MSB8)
>gi|4982042|gb|AAD36544.1|AE001798_9 (AE001798)
methionine aminopeptidase [Thermotoga maritima]
Length = 250
Score = 90.5 bits (221), Expect = 3e-17
Identities = 76/256 (29%), Positives = 122/256 (46%), Gaps = 48/256 (18%)
Query: 127 VKSDEEIKIIEKACEIADKAVMAAIEEVTE----GKKEREIAAKVEYLMKMNGAEKPAFD 182
+K+ EI+ ++KA KAV A+ EV + GK ++ V + K KPAF
Sbjct: 4 IKTPSEIEKMKKA----GKAVAVALREVRKVIVPGKTAWDVETLVLEIFKKLRV-KPAFK 58
Query: 183 TIIASGYRSA--------LPHGVA-SDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSP 233
GY+ A + HG+ +K ++GD+V +D+GA+Y D T +VG
Sbjct: 59 GY--GGYKYATCVSVNEEVVHGLPLKEKVFKEGDIVSVDVGAVYQGLYGDAAVTYIVGET 116
Query: 234 NEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYG---DYFIHSLGHGVG 290
+E+ +E+ + E +KA++ +PGI ++ + ++ G+ DY +GHGVG
Sbjct: 117 DERGKELVRVTREVLEKAIKMIKPGIRLGDVSHCIQETVESVGFNVIRDY----VGHGVG 172
Query: 291 LEIHEWPGVSQYDE----TVLKEGMVITIEPGI------YIPKFGG-----------VRI 329
E+HE P + Y VL++GM + IEP + + K G
Sbjct: 173 RELHEDPQIPNYGTPGTGVVLRKGMTLAIEPMVSEGDWRVVVKEDGWTAVTVDGSRCAHF 232
Query: 330 EDTIVITKTGARRLTK 345
E TI+IT+ GA LTK
Sbjct: 233 EHTILITENGAEILTK 248
>dbj|BAA88830.1| (AB016788) creatine amidinohydrolase [Alcaligenes sp.]
Length = 404
Score = 90.1 bits (220), Expect = 3e-17
Identities = 85/357 (23%), Positives = 157/357 (43%), Gaps = 27/357 (7%)
Query: 14 FMNENSIDAVLITKNPNIYYLSGASPLAGGY---ILVNNDGATLYVPELEYEMAKEES-- 68
+M +N++DA L T I Y SG G ++++++ AT ++ S
Sbjct: 36 WMAKNNVDAALFTSYHCINYYSGWLYCYFGRKYGMVIDHNNATTISAGIDGGQPWRRSFG 95
Query: 69 -KIPVEKFKRRDDFYKVFE----GVKVLGIE-GSLSYSFVEDLKEKGKISEFKKVDDVIK 122
I + RRD+FY+ G K +GIE ++ F L+E EF +
Sbjct: 96 DNITYTDW-RRDNFYRAVRQLTTGAKRIGIEFDHVNLDFRRQLEEALPGVEFVDISQPSM 154
Query: 123 EMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFD 182
MR +KS EE K+I + + D A + G E E+A M A+ F
Sbjct: 155 WMRTIKSLEEQKLIREGARVCDVGGAACAAAIKAGVPEHEVAIATTNAMIREIAKSFPFV 214
Query: 183 TII------ASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
++ SG + H +++ ++ GD++ ++ + Y + + RT+ ++
Sbjct: 215 ELMDTWTWFQSGINTDGAHNPVTNRIVQSGDILSLNTFPMIFGYYTALERTLFCDHVDDA 274
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEW 296
+I+E + ++ +E +PG K++ + +E+ Y GH G+ H +
Sbjct: 275 SLDIWEKNVAVHRRGLELIKPGARCKDIAIELNEMYREWDLLKYRSFGYGHSFGVLCHYY 334
Query: 297 ---PGVSQYD--ETVLKEGMVITIEPGIYIPK----FGGVRIEDTIVITKTGARRLT 344
GV + +T LK GMV+++EP + +P+ GG R D +++ + GA +T
Sbjct: 335 GREAGVELREDIDTELKPGMVVSMEPMVMLPEGMPGAGGYREHDILIVGEDGAENIT 391
>gi|10955071 agcA [Agrobacterium tumefaciens] >gi|2329863|emb|CAA80685.1|
(Z23166) catabolic mannopine cyclase [Agrobacterium
tumefaciens] >gi|8572699|gb|AAF77145.1| (AF242881) agcA
[Agrobacterium tumefaciens]
Length = 402
Score = 90.1 bits (220), Expect = 3e-17
Identities = 67/245 (27%), Positives = 122/245 (49%), Gaps = 19/245 (7%)
Query: 120 VIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIA-AKVEYLMKMNG--- 175
+++++ +K+D ++ I +A ++ + AA + + G E ++ A + +K +
Sbjct: 155 ILRDLLALKNDAVVEGIRRATDVVAQQYAAARQAIVPGAAEWQVTLASLTAAIKRSADFL 214
Query: 176 ---AEKPAF----DTIIASG-YRSALPHGVASDKRIEKGDLVVIDL-GALYNHYNSDITR 226
E+P F ++ SG R+A H + + G+ V I L G +Y Y R
Sbjct: 215 GEDVEQPRFWPHQMNMVGSGPERTARCHCSGGGRIMNDGEHVQICLCGQVYCGYGICFDR 274
Query: 227 TVVVGSPNE--KQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHS 284
+ VGS + R++ +AQ+ A+ +PG T E+ + A ++I+ G+ F+H
Sbjct: 275 PIPVGSKELPLELRKVVNFARQAQEAALARIKPGATAGEVHAAAVDVIESGGWDRPFLHR 334
Query: 285 LGHGVGLEIHEWPGVSQYDETV--LKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARR 342
G G+G +W G+ + L+ GMV+++EPGIY+ GG R DT+++T TG
Sbjct: 335 TGRGIGYS--DWDGIELKANSPVRLEAGMVLSVEPGIYVDGVGGARFGDTVLVTDTGYEV 392
Query: 343 LTKTE 347
LT E
Sbjct: 393 LTPFE 397
>pir||E71651 hypothetical protein RP482 - Rickettsia prowazekii
>gi|3861035|emb|CAA14935.1| (AJ235272) unknown
[Rickettsia prowazekii]
Length = 591
Score = 89.7 bits (219), Expect = 4e-17
Identities = 87/308 (28%), Positives = 141/308 (45%), Gaps = 36/308 (11%)
Query: 46 LVNNDGATLYVPELEYEMAKEESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDL 105
++N +PE E+E +SK + Y + + + + I ++ V+ +
Sbjct: 232 IINARPEITILPEKEFENILRDSK----------NRYLIDDSITSVHIMDLIANKKVKKI 281
Query: 106 KEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEI-ADKAVMAAIEEVTEGKKEREIA 164
E +++ K D IK D IK CE A+ + + E V EI
Sbjct: 282 VEPCLLAKACKNDIEIKHA----IDFHIKDAVALCEFFAEFFLYHSSENVNSCFHSHEII 337
Query: 165 AKVEYLMKMN-------GAEKPAFDTIIASGYRSALPHGVASDK---RIEKGDLVVIDLG 214
+ +K+ G +F I SA+ H A+ K +IE +++ID G
Sbjct: 338 TEHSLCLKLTAQRAKQEGYVSDSFHAICGFQENSAIIHYRANPKTAKKIEGHGILLIDSG 397
Query: 215 ALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPG--ITTKELDSIARNII 272
A Y +DITRT++VG P +Q++ Y VL+ A P +T LD +AR
Sbjct: 398 AQYKGATTDITRTIIVGIPTCEQKKRYTQVLKGHIALTRAKFPKNIVTGANLDILAR--- 454
Query: 273 KEYGYGDY--FIHSLGHGVG--LEIHEWP-GVSQYDETVLKEGMVITIEPGIYIPKFGGV 327
+Y + D + H GHGVG L +HE P ++ ++ +LK GM+++ EPG YIP G+
Sbjct: 455 -QYLWQDMIDYPHGTGHGVGSFLSVHEGPQSINLSNKIILKAGMILSNEPGFYIPGKYGI 513
Query: 328 RIEDTIVI 335
RIE+ I +
Sbjct: 514 RIENLIYV 521
>sp|Q9Z6Q0|AMPM_CHLPN METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435564|pir||E72008 methionine aminopeptidase -
Chlamydophila pneumoniae (strain CWL029)
>gi|4377339|gb|AAD19146.1| (AE001681) Methionine
Aminopeptidase [Chlamydophila pneumoniae CWL029]
>gi|8979382|dbj|BAA99216.1| (AP002548) methionine
aminopeptidase [Chlamydophila pneumoniae J138]
Length = 291
Score = 89.7 bits (219), Expect = 4e-17
Identities = 69/237 (29%), Positives = 109/237 (45%), Gaps = 36/237 (15%)
Query: 134 KIIEKACEIADKAVMA-AIEEVTEG--KKEREIAAKVEYLMKMNGAEKPAFDTIIASGYR 190
+I+++ C+ + K V ++E+++ KK IAA Y P F I +
Sbjct: 61 RILDELCKASQKGVTTNELDELSQELHKKYDAIAAPFHY-------GSPPFPKTICTSLN 113
Query: 191 SALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKK 250
+ HG+ +D ++ GD++ ID+ + + Y D +R V++G E +++I + LE
Sbjct: 114 EVICHGIPNDIPLKDGDIMNIDVSCIVDGYYGDCSRMVMIGEVPEIKKKICQAALECLND 173
Query: 251 AVEAARPGITTKELDSIARNIIKEYGYG--DYFIHSLGHGVGLEIHEWPGVSQY---DET 305
++ +PGI E+ YG+ D F+ GHGVG+E HE P V Y
Sbjct: 174 SIAILKPGIPLCEIGEAIEARADTYGFSVVDQFV---GHGVGIEFHENPYVPHYRNRSMI 230
Query: 306 VLKEGMVITIEPGIYIPKFGGV------------------RIEDTIVITKTGARRLT 344
L GM+ TIEP I + K GV + E TI IT+TG LT
Sbjct: 231 PLAPGMIFTIEPMINVGKKEGVVDPKNQWEARTCDNQPSAQWEHTIAITETGYEILT 287
>pir||A81531 methionine aminopeptidase CP0844 [imported] - Chlamydophila
pneumoniae (strain AR39) >gi|7189756|gb|AAF38634.1|
(AE002244) methionine aminopeptidase [Chlamydophila
pneumoniae AR39]
Length = 266
Score = 89.7 bits (219), Expect = 4e-17
Identities = 69/237 (29%), Positives = 109/237 (45%), Gaps = 36/237 (15%)
Query: 134 KIIEKACEIADKAVMA-AIEEVTEG--KKEREIAAKVEYLMKMNGAEKPAFDTIIASGYR 190
+I+++ C+ + K V ++E+++ KK IAA Y P F I +
Sbjct: 36 RILDELCKASQKGVTTNELDELSQELHKKYDAIAAPFHY-------GSPPFPKTICTSLN 88
Query: 191 SALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKK 250
+ HG+ +D ++ GD++ ID+ + + Y D +R V++G E +++I + LE
Sbjct: 89 EVICHGIPNDIPLKDGDIMNIDVSCIVDGYYGDCSRMVMIGEVPEIKKKICQAALECLND 148
Query: 251 AVEAARPGITTKELDSIARNIIKEYGYG--DYFIHSLGHGVGLEIHEWPGVSQY---DET 305
++ +PGI E+ YG+ D F+ GHGVG+E HE P V Y
Sbjct: 149 SIAILKPGIPLCEIGEAIEARADTYGFSVVDQFV---GHGVGIEFHENPYVPHYRNRSMI 205
Query: 306 VLKEGMVITIEPGIYIPKFGGV------------------RIEDTIVITKTGARRLT 344
L GM+ TIEP I + K GV + E TI IT+TG LT
Sbjct: 206 PLAPGMIFTIEPMINVGKKEGVVDPKNQWEARTCDNQPSAQWEHTIAITETGYEILT 262
>pir||C82367 aminopeptidase P VC0067 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9654463|gb|AAF93245.1| (AE004098)
aminopeptidase P [Vibrio cholerae]
Length = 597
Score = 89.3 bits (218), Expect = 6e-17
Identities = 67/217 (30%), Positives = 108/217 (48%), Gaps = 19/217 (8%)
Query: 138 KACEIADKAVMAAI-----EEVTEGK--KEREIAAKVEYLMKMNGAEKP-AFDTIIASGY 189
+AC I D A M EV G+ E E+A ++E + + +FDTI A+G
Sbjct: 311 RACHIRDGAAMVQFLAWLDNEVANGRLHNEAELADRLEAFRRQDPTLVDLSFDTISAAGT 370
Query: 190 RSALPHGVASDK----RIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVL 245
+A+ H ++ ++ L ++D G Y +DITRTV +G + + ++ + +VL
Sbjct: 371 NAAMCHYNHQNQPEPGQLSMDSLYLVDSGGQYLDGTTDITRTVAIGQVSAEMKQQFTLVL 430
Query: 246 EAQKKAVEAARP-GITTKELDSIARNIIKEYGYGDYFIHSLGHGVG--LEIHEWPG--VS 300
+ A P G T +LD +AR + GY + H GHGVG L +HE P
Sbjct: 431 KGHIALARARFPKGTTGSQLDVLARQHLWAQGYD--YDHGTGHGVGHFLSVHEGPQRIAK 488
Query: 301 QYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITK 337
++ L+ GMV++ EPG Y G+RIE+ ++T+
Sbjct: 489 VHNSVALRPGMVLSNEPGYYRADAFGIRIENLELVTE 525
>gb|AAD27841.1|AF124600_4 (AF124600) putative cytoplasmic peptidase [Corynebacterium
glutamicum]
Length = 217
Score = 88.9 bits (217), Expect = 8e-17
Identities = 60/195 (30%), Positives = 104/195 (52%), Gaps = 8/195 (4%)
Query: 20 IDAVLITKNPNIYYLSGASPLAGGYILVNNDGATLYVPELEYEMAKEESKIPVEKFKRRD 79
ID++L+T ++ YLSG + + G ++VN D + + Y E +E R
Sbjct: 24 IDSILVTSPIHVRYLSGFTG-SNGALIVNKDLSAQICTDGRYTTQIGEEVPDIEALIERA 82
Query: 80 DFYKVF---EGVKVLGIEGS-LSYSFVEDLKEKGKIS-EFKKVDDVIKEMRIVKSDEEIK 134
+ EG + + IE + + ++ L+E + E V V++ +R+ K E+
Sbjct: 83 SATTLLAQVEGPRRIAIEAAQTTLDQLDSLREATQEDVELIPVSGVVESIRLTKDSFELD 142
Query: 135 IIEKACEIADKAV--MAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTIIASGYRSA 192
+ +A +A + A E+ EG+ ER++AA +EY M++ GAE+P+FDTI+ASG SA
Sbjct: 143 RLRDVAALASQAFEDLLAAGELAEGRSERQVAADLEYRMRLLGAERPSFDTIVASGPNSA 202
Query: 193 LPHGVASDKRIEKGD 207
PH A D+ +++GD
Sbjct: 203 KPHHGAGDRILQRGD 217
>sp|P55666|Y4TL_RHISN HYPOTHETICAL HYDROLASE/PEPTIDASE Y4TL >gi|2182642|gb|AAB91865.1|
(AE000098) Y4tL [Rhizobium sp. NGR234]
Length = 390
Score = 88.5 bits (216), Expect = 1e-16
Identities = 83/364 (22%), Positives = 158/364 (42%), Gaps = 30/364 (8%)
Query: 15 MNENSIDAVLITKNPNIYYLSGASPLAG----GYILVNNDGATLYV------PELEYEMA 64
M IDA+++ + +I YL+G + +G ++ +ND ++ P ++
Sbjct: 26 MGRLEIDALIVGSSADITYLTGYTAKSGYVPQALVISSNDEEPTFILRRQDAPAAIHQTF 85
Query: 65 KEESKI-----------PVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKE-KGKIS 112
+ K+ + + DF +G G+ L Y V ++ K ++
Sbjct: 86 MDRDKVIGYSEALIGNPDKDGYDAVVDFLNERDGANKRGVGVQLGYLSVRSAEKFKTRLP 145
Query: 113 EFKKVDDV--IKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYL 170
+ VD + +R++KSD EI ++ A IAD V A E + G +E ++ A V
Sbjct: 146 SARIVDCTHSVAWIRMIKSDLEISMMRDAAAIADAGVQKAFEVIRPGVREADVMADVAAQ 205
Query: 171 MKMNGAEKPAFDTI---IASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRT 227
+ K D S R+ H S+ I G + +++ + + Y S I RT
Sbjct: 206 LARGTNGKAGTDLASMYFCSSPRTGTCHIRWSEDVIRDGSQINLEIAGVRHGYVSAIMRT 265
Query: 228 VVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGH 287
VG+P+++ R I++ + + A+ +PG T ++ + I++ G+ G+
Sbjct: 266 FSVGAPSDRLRRIHDAEVLGLEAALSTVKPGATCSDVANAFYRTIEKSGFQK--DSRCGY 323
Query: 288 GVGLEIHE-WPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKT 346
+G++ E + D T LK M + G +I + G + +T +T+ G LTK+
Sbjct: 324 AIGIDWSEPTASLKDGDMTKLKPNMTFHLMLGNWIEEDFGYVLSETFRVTEAGCEVLTKS 383
Query: 347 EREL 350
R+L
Sbjct: 384 PRQL 387
>gb|AAD37463.1| (AF072304) creatinase [Pseudomonas putida]
Length = 403
Score = 86.2 bits (210), Expect = 5e-16
Identities = 84/364 (23%), Positives = 156/364 (42%), Gaps = 38/364 (10%)
Query: 14 FMNENSIDAVLITKNPNIYYLSGASPLAGG--YILVNNDGATLYVPE-----LEYEMAKE 66
++ +N+IDA + T NI Y S + G Y LV A + + +
Sbjct: 34 YLAQNNIDAAVFTSYHNINYYSDFLYCSFGRPYALVVTQEAVVSISANIDGGQPWRRTVG 93
Query: 67 ESKIPVEKFKRRDDFYKVFEGVKVLGIEG----SLSYSFVEDLKEKGKISEFKKVDDVIK 122
I ++R + F + + + G G L+ + L + +E +
Sbjct: 94 TDNIIYTDWQRDNYFVAIQQALPKAGRIGIEFDHLNLMNRDKLASRYPQAELVDIAAPCM 153
Query: 123 EMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA----EK 178
MR++KS EE II + +AD A +E + + E E+A M A +
Sbjct: 154 RMRMIKSAEEHAIIRQGARVADIGGAAVVEALRDQVPEYEVALHATQAMVREIARTYPDS 213
Query: 179 PAFDTI--IASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
DT SG + H + +++ KGD++ ++ + Y + + RT+ + +++
Sbjct: 214 ELMDTWTWFQSGINTDGAHNPVTSRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDE 273
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKE--------YGYGDYF---IHSL 285
++E+ ++ + +E +PG+ + ++ I E +GYG F H
Sbjct: 274 HLRLWEVNVKVHEAGLELVKPGMRSSDIALQLNEIFLEHDLLQYRTFGYGHSFGTLSHYY 333
Query: 286 GHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPK----FGGVRIEDTIVITKTGAR 341
G GLE+ E +TVL+ GMV++IEP I +P+ GG R D +++ + G+
Sbjct: 334 GREAGLELRE------DIDTVLEPGMVVSIEPMIMLPEGLPGAGGYREHDILIVNEHGSE 387
Query: 342 RLTK 345
+TK
Sbjct: 388 NITK 391
>emb|CAA19220.1| (AL023653) dJ753P9.1 (Aminopeptidase P (EC 3.4.11.9,
XAA-Pro/X-Pro/Proline/Aminoacylproline Aminopeptidase))
[Homo sapiens] >gi|11066157|gb|AAG28480.1| (AF195953)
membrane-bound aminopeptidase P [Homo sapiens]
Length = 674
Score = 86.2 bits (210), Expect = 5e-16
Identities = 57/180 (31%), Positives = 94/180 (51%), Gaps = 12/180 (6%)
Query: 168 EYLMKMNGAEK----PAFDTIIASGYRSALPHGVAS---DKRIEKGDLVVIDLGALYNHY 220
E + K G E+ P+F+TI ASG +AL H + ++++ ++ ++D G Y
Sbjct: 399 EIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDG 458
Query: 221 NSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITT-KELDSIARNIIKEYGYGD 279
+DITRTV G+P+ Q+E Y VL P T+ + +++ AR + + G
Sbjct: 459 TTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLN- 517
Query: 280 YFIHSLGHGVG--LEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITK 337
+ H GHG+G L +HEWP Q + + +GM +IEPG Y G+R+ED ++ +
Sbjct: 518 -YGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVE 576
>gi|10880126 X-prolyl aminopeptidase 2, membrane-bound; aminoacylproline
aminopeptidase; aminopeptidase P; X-prolyl
aminopeptidase 2 (aminopeptidase P) [Homo sapiens]
>gi|10190809|gb|AAB96394.2| (U90724) aminopeptidase P
[Homo sapiens]
Length = 674
Score = 86.2 bits (210), Expect = 5e-16
Identities = 57/180 (31%), Positives = 94/180 (51%), Gaps = 12/180 (6%)
Query: 168 EYLMKMNGAEK----PAFDTIIASGYRSALPHGVAS---DKRIEKGDLVVIDLGALYNHY 220
E + K G E+ P+F+TI ASG +AL H + ++++ ++ ++D G Y
Sbjct: 399 EIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDG 458
Query: 221 NSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITT-KELDSIARNIIKEYGYGD 279
+DITRTV G+P+ Q+E Y VL P T+ + +++ AR + + G
Sbjct: 459 TTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLN- 517
Query: 280 YFIHSLGHGVG--LEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITK 337
+ H GHG+G L +HEWP Q + + +GM +IEPG Y G+R+ED ++ +
Sbjct: 518 -YGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVE 576
>gb|AAD52565.4|AF170566_1 (AF170566) creatinase [Pseudomonas putida]
Length = 403
Score = 85.4 bits (208), Expect = 9e-16
Identities = 84/364 (23%), Positives = 155/364 (42%), Gaps = 38/364 (10%)
Query: 14 FMNENSIDAVLITKNPNIYYLSGASPLAGG--YILVNNDGATLYVPE-----LEYEMAKE 66
++ +N+IDA + T NI Y S + G Y LV A + + +
Sbjct: 34 YLAQNNIDAAVFTSYHNINYYSDFLYCSFGRPYALVVTQEAVVSISANIDGGQPWRRTVG 93
Query: 67 ESKIPVEKFKRRDDFYKVFEGVKVLGIEG----SLSYSFVEDLKEKGKISEFKKVDDVIK 122
I ++R + F + + + G G L+ + L + +E +
Sbjct: 94 TDNIIYTDWQRDNYFVAIQQALPKAGRIGIEFDHLNLMNRDKLASRYPQAELVDIAAPCM 153
Query: 123 EMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA----EK 178
MR++KS EE II + +AD A +E + + E E+A M A +
Sbjct: 154 RMRMIKSAEEHAIIRQGARVADIGGAAVVEALRDQVPEYEVALHATQAMVREIARTYPDS 213
Query: 179 PAFDTI--IASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
DT SG + H + +++ KGD++ ++ + Y + + RT+ + +++
Sbjct: 214 ELMDTWTWFQSGINTDGAHNPVTSRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDE 273
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKE--------YGYGDYF---IHSL 285
++E+ ++ + +E +PG+ ++ I E +GYG F H
Sbjct: 274 HLRLWEVNVKVHEAGLELVKPGMRCSDIALQLNEIFLEHDLLQYRTFGYGHSFGTLSHYY 333
Query: 286 GHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPK----FGGVRIEDTIVITKTGAR 341
G GLE+ E +TVL+ GMV++IEP I +P+ GG R D +++ + G+
Sbjct: 334 GREAGLELRE------DIDTVLEPGMVVSIEPMIMLPEGLPGAGGYREHDILIVNEHGSE 387
Query: 342 RLTK 345
+TK
Sbjct: 388 NITK 391
>sp|Q9Z9J4|AMPM_BACHD METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|11264635|pir||T44405 methionyl aminopeptidase (EC
3.4.11.18) map [imported] - Bacillus halodurans
>gi|4512426|dbj|BAA75293.1| (AB017508) map homologue
(identity of 81% to B. subtilis ) [Bacillus halodurans]
>gi|10172768|dbj|BAB03875.1| (AP001507) methionine
aminopeptidase [Bacillus halodurans]
Length = 248
Score = 85.4 bits (208), Expect = 9e-16
Identities = 62/248 (25%), Positives = 111/248 (44%), Gaps = 27/248 (10%)
Query: 124 MRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP---- 179
M I K++ E++I+ +A I + G +++ E ++ +GA
Sbjct: 1 MIICKTERELEIMREAGRIVALTHQEIKLHIQPGITTKKLDEIAETFIRSHGATPSFKGY 60
Query: 180 -AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQR 238
F I + L HG+ ++ +++GD++ +D+GA YN Y+ D T VG+ +++ +
Sbjct: 61 NGFTGSICASVNEELVHGIPGNRVLKEGDIISVDIGAKYNGYHGDSAWTYAVGNISDEDQ 120
Query: 239 EIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPG 298
++ ++ + K +E A+ G ++ ++ + GY +GHGVG +HE P
Sbjct: 121 DLLDVTETSLYKGLEQAKAGARLSDISHAIQSYAEPRGYA-IVREYVGHGVGQNLHEDPQ 179
Query: 299 VSQYDE----TVLKEGMVITIEPGI-----YIPKFGG------------VRIEDTIVITK 337
+ Y LK GMV+ IEP + Y+ E TI IT+
Sbjct: 180 IPHYGPPGKGPRLKPGMVLAIEPMVNAGSRYVRTLSDNWTVVTVDGKKCAHFEHTIAITE 239
Query: 338 TGARRLTK 345
TG LTK
Sbjct: 240 TGYEILTK 247
>gi|11420265 X-prolyl aminopeptidase 2, membrane-bound [Homo sapiens]
Length = 674
Score = 83.9 bits (204), Expect = 3e-15
Identities = 56/180 (31%), Positives = 93/180 (51%), Gaps = 12/180 (6%)
Query: 168 EYLMKMNGAEK----PAFDTIIASGYRSALPHGVAS---DKRIEKGDLVVIDLGALYNHY 220
E + K G E+ P+F+TI ASG +AL H + ++++ ++ ++D G Y
Sbjct: 399 EIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDG 458
Query: 221 NSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITT-KELDSIARNIIKEYGYGD 279
+DITRTV G+P+ +E Y VL P T+ + +++ AR + + G
Sbjct: 459 TTDITRTVHWGTPSAFHQEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLN- 517
Query: 280 YFIHSLGHGVG--LEIHEWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITK 337
+ H GHG+G L +HEWP Q + + +GM +IEPG Y G+R+ED ++ +
Sbjct: 518 -YGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVE 576
>pir||C70108 peptidase homolog - Lyme disease spirochete
>gi|2687937|gb|AAC66444.1| (AE001119) peptidase,
putative [Borrelia burgdorferi]
Length = 592
Score = 83.5 bits (203), Expect = 3e-15
Identities = 93/358 (25%), Positives = 167/358 (45%), Gaps = 34/358 (9%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYY---LSGA----SPLAGGYILVN---NDGATLY 55
EKIK I + +N D +IT I + L GA S L ++L++ N L+
Sbjct: 170 EKIKSIYLILEKNLADFYVITALDEIAWVLNLRGADVEESALFYSFLLISRNKNRKNVLF 229
Query: 56 VPELEYEMAKEESKIPVEKFKRRD--DFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISE 113
V + + +E+ + +E F+ +FY + +K EG SF +++ + E
Sbjct: 230 VDXKKLDSGVKEA-LEMENFEIESYSNFYCFLDKIKH---EGKFFVSFYANVRVLKVLGE 285
Query: 114 FKKV--DDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKK-------EREIA 164
+ + +I ++ +K+D E+ +++A I A++ + + K E ++A
Sbjct: 286 TNIILGESIISSLKALKTDYELLKMKEAHIIDAIALIKFLRKFKSLSKVELSELDEIDVA 345
Query: 165 AKVEYLMKMN-GAEKPAFDTIIASGYRSALPHGVAS-DKRIEKGDLVVIDLGALYNHYNS 222
+ + K+N +FD+I+ ALPH ++I L++ID G Y +
Sbjct: 346 DMLLHFRKLNKDFFSSSFDSIVGFRENGALPHYKPKRGRKINTNGLLLIDSGGSYFGLGT 405
Query: 223 -DITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARP-GITTKELDSIARNIIKEYGYGDY 280
D+TR ++G +++++ Y +VL+A P G + LD I R + +
Sbjct: 406 TDVTRVFLIGDASDEEKRDYTLVLKAFIGLSSLKFPYGSSGAFLDGICRLPLLKNELN-- 463
Query: 281 FIHSLGHGVG--LEIHEWP-GVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVI 335
FIH GHGVG L +HE P +S + K V++IEPG+Y G+RIE+ + +
Sbjct: 464 FIHGTGHGVGFFLNVHELPVSISPNSSYLFKGSEVVSIEPGLYRTFSHGIRIENLVFV 521
>pir||T32753 hypothetical protein W03G9.4 - Caenorhabditis elegans
>gi|2773225|gb|AAB96739.1| (AF039716) Similar to
aminopeptidase; coded for by C. elegans cDNA yk91g4.3;
coded for by C. elegans cDNA yk324c12.3; coded for by C.
elegans cDNA yk460e4.3; coded for by C. elegans cDNA
yk258c12.3; coded for by C. elegans cDNA yk285g6.3;
coded for by >
Length = 616
Score = 83.5 bits (203), Expect = 3e-15
Identities = 89/359 (24%), Positives = 159/359 (43%), Gaps = 36/359 (10%)
Query: 6 EKIKRIIEFMNENSIDAVLITKNPNIYYLSGA-------SPLAGGYILVNNDGATLYVPE 58
+K++ + E + + DA + T ++ +L +PLA Y+ V +++
Sbjct: 182 KKVENLREKLKQKKCDAAVFTLLDDVMWLLNIRGSDIPYNPLAYSYLFVAMREIHVFIDN 241
Query: 59 LEYEMAKE----ESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKI--S 112
+ + +S + + + + + K E + Y E G I
Sbjct: 242 EKLDEKSRAHFHKSNVSIHPYGEVYSWISNWLKAKEASKEPHMVYLTPETNYAIGSIIGE 301
Query: 113 EFKKVD-DVIKEMRIVKSDEEIKIIEKACEIADKAVMAAI-----EEVTEGKK--EREIA 164
E VD +++ + K+D E++ + + + D A + +E+ GK+ E E+A
Sbjct: 302 ENSMVDTSLVQTAKATKNDHEMQGMRNS-HLRDSAALVEFLCWLEKELLSGKRYTEIELA 360
Query: 165 AKVEYLMKMNGAEKP-AFDTIIASGYRSALPH----GVASDKRIEKGDLVVIDLGALYNH 219
K+++L + +FDTI A G +ALPH G + +++ + ++D GA Y
Sbjct: 361 DKIDHLRSLQDKYVTLSFDTISAVGDHAALPHYKPLGESGNRKAAANQVFLLDSGAHYGD 420
Query: 220 YNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARP-GITTKELDSIARNIIKEYGYG 278
+D+TRTV +P ++ +VL+ A P GI LD++ R+ + + G
Sbjct: 421 GTTDVTRTVWYTNPPKEFILHNTLVLKGHINLARAKFPDGIYGSRLDTLTRDALWKLGLD 480
Query: 279 DYFIHSLGHGVG--LEIHEWP-GVSQYDETV---LKEGMVITIEPGIYIPKFGGVRIED 331
F H GHGVG L +HE P G+ L V+TIEPG Y + G+RIE+
Sbjct: 481 --FEHGTGHGVGHYLNVHEGPIGIGHRSVPTGGELHASQVLTIEPGFYAKEKYGIRIEN 537
>gb|AAC16431.1| (AF063007) similar to the peptidase family M; Pfam domain PF00557
(pep_M24), Score=99.2, E-value=2.6e-26, N=1
[Caenorhabditis elegans]
Length = 383
Score = 83.1 bits (202), Expect = 4e-15
Identities = 66/286 (23%), Positives = 127/286 (44%), Gaps = 37/286 (12%)
Query: 93 IEGSLSYSFVEDLKEKG-------KISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADK 145
++ + V+ LK+K K S F + + I+ R++KS E+ + C + +
Sbjct: 80 VQAKANSKIVQALKKKSDFRGFQSKNSNFVQFLNEIERRRVIKSPSEMSSMRDVCNVGAQ 139
Query: 146 AVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIEK 205
+ + I + E I +E+ + G+E A+ +IA G R+ H + ++ +
Sbjct: 140 TMSSMISGSRDLHNENAICGLLEFEGRRRGSEMQAYPPVIAGGVRANTIHYLDANNDLNP 199
Query: 206 GDLVVIDLGALYNHYNSDITRTV-VVGSPNEKQREIYEIVLEAQKK------AVEAARPG 258
+ V++D G N Y SD+TR + G ++ Q +YE +L ++ ++E R
Sbjct: 200 RECVLVDAGCDLNGYVSDVTRCFPISGFWSDAQLSLYEALLYVHEELLTYAHSMEKVRLS 259
Query: 259 ITTKELDSIARNIIKEYGY-------------GDYFIHSLGHGVGLEIHEWPGVSQYDET 305
+ ++ + E G H + H +G+++H+ P VS+ +
Sbjct: 260 ALFRRMNELLAASFTELGLIRSTDHKEMIHQAEKLCPHHVSHYLGMDVHDCPTVSR--DI 317
Query: 306 VLKEGMVITIEPGIYIP------KFGGV--RIEDTIVITKTGARRL 343
L + TIEPG+Y+P +F G+ RIED + ++ G L
Sbjct: 318 DLPPNVPFTIEPGVYVPMDWPVKEFRGIGYRIEDDVATSEAGGIEL 363
>sp|O66489|AMPM_AQUAE METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435557|pir||F70307 methionyl aminopeptidase -
Aquifex aeolicus >gi|2982825|gb|AAC06448.1| (AE000672)
methionyl aminopeptidase [Aquifex aeolicus]
Length = 258
Score = 82.3 bits (200), Expect = 7e-15
Identities = 69/252 (27%), Positives = 111/252 (43%), Gaps = 36/252 (14%)
Query: 129 SDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAE------KPAFD 182
S EI+ I KA +I + + E V G ++ + GA+ KP F
Sbjct: 7 SQREIEKIRKASQIVAEVLHIVAENVKPGVSTWDLEMIARKETEKRGAKPAFLGYKPPFS 66
Query: 183 TI-----IASGYRSALPHGVAS-DKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
+ + + HG+ +K I++GD+V ID GA+Y+ Y D TV+ G + +
Sbjct: 67 DVRYPAALCISINDEVVHGLPKKEKVIKEGDVVSIDFGAIYDGYAGDSAITVIAGKGSPE 126
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEW 296
+++ E EA A+E A PG ++ ++YG+ + GHGVG ++H+
Sbjct: 127 AQKLLEATKEALYNAIEKALPGKKVGDITKAIHETAEKYGFKTILRYG-GHGVGRKVHQE 185
Query: 297 PGVSQYDETV------LKEGMVITIEPGIYI---------------PKFGGV--RIEDTI 333
P V + + L++GMVI IEP + I K G + E T+
Sbjct: 186 PFVPNNVKDIGKKNPRLRQGMVIAIEPMLSIGTEETVEDGDGWTVKTKDGSLAAHFEHTV 245
Query: 334 VITKTGARRLTK 345
ITK G LT+
Sbjct: 246 AITKKGPVILTE 257
>dbj|BAA95761.1| (AB028607) methionine aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 342
Score = 82.3 bits (200), Expect = 7e-15
Identities = 64/257 (24%), Positives = 114/257 (43%), Gaps = 28/257 (10%)
Query: 113 EFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMK 172
E KV ++ E++I S +K+ +KACE+A + + A V EI V ++
Sbjct: 86 ESSKVPEISSELQIPDSIGIVKM-KKACELAARVLDYAGTLVRPFVTTDEIDKAVHQMVI 144
Query: 173 MNGAEKP-----AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRT 227
GA F + + + HG+ + ++ GD++ ID+ + Y+ D ++T
Sbjct: 145 EFGAYPSPLGYGGFPKSVCTSVNECMFHGIPDSRPLQNGDIINIDVAVYLDGYHGDTSKT 204
Query: 228 VVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGH 287
+ G N +++ ++ E +K + + G + K++ I +YGY +GH
Sbjct: 205 FLCGDVNGSLKQLVKVTEECLEKGISVCKDGASFKQIGKIISEHAAKYGYN--MERFIGH 262
Query: 288 GVGLEIHEWPGV---SQYDETVLKEGMVITIEPGI---------------YIPKFGG--V 327
GVG +H P + + Y+ + EG T+EP + + GG
Sbjct: 263 GVGTVLHSEPLIYLHNDYELEYMIEGQTFTLEPILTIGTTEFVTWPDKWTIVTADGGPAA 322
Query: 328 RIEDTIVITKTGARRLT 344
+ E TI+IT TGA LT
Sbjct: 323 QFEHTILITTTGAEILT 339
>gb|AAF69574.1|AC013257_1 (AC013257) Proline dipeptidase [Leishmania major]
Length = 484
Score = 82.3 bits (200), Expect = 7e-15
Identities = 99/415 (23%), Positives = 165/415 (38%), Gaps = 89/415 (21%)
Query: 18 NSIDA-VLITKNPNIYYLSGAS-PLAGGYILVNNDGATLYVPELEYEMAKEESKIP---- 71
NS D L + +YL GA P A G +L + ++P L + A +P
Sbjct: 52 NSTDCNYLFVQESYFHYLFGAEIPDAYGAVLAGGK-SVFFIPRLPADFATWMGPLPTPQS 110
Query: 72 ------VEKFKRRDDFYKVFEGVKVLGIE---GSLSYSFVEDLKEK-----GKISEFKKV 117
VE+ D+ +V V E G+ + S +E L+ K + +
Sbjct: 111 VKAQLEVEEVHYVDEMEQVLMSCGVHTAEVLKGTNTDSGLEVLQAKLPEGTALATSTDYL 170
Query: 118 DDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA- 176
V+ R K+ E +++ C+++ A + ++ G + + + + + NG
Sbjct: 171 YRVLSSQRCYKTALEADVLKYVCKVSSAAHVKVMQIAKPGMSQHHLESTFLHDVYYNGGC 230
Query: 177 EKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVV-GSPNE 235
+ ++ I A+G A H ++ IE G + ++D+G Y Y +DIT + V G E
Sbjct: 231 RRVSYTCICATGPHGATLHYPDNNCVIEDGTMALLDMGGNYRGYAADITCSFPVNGKFTE 290
Query: 236 KQREIYEIVLEAQKKAVEAARPG----------ITTKELDSIARNIIKEYGYGD------ 279
Q+ IY VL+A + + A +PG I T + IA I+K GD
Sbjct: 291 AQKTIYNAVLDAHDRVMRAMKPGVEWVDMHLLAIRTTCMHLIAAGILK----GDIETLMA 346
Query: 280 -----YF-IHSLGHGVGLEIHEWPGVSQ--------------YDETVLKEGMVITIEPGI 319
YF H LGH +G+++H+ G + ++EG+ +T+EPG
Sbjct: 347 KEIMQYFQPHGLGHLIGIDVHDVGGYMEGCPERPTKKDCCRLRTARTIEEGLYMTVEPGC 406
Query: 320 YI--------------------------PKFGGVRIEDTIVITKTGARRLTKTER 348
Y FGGVRIE +++TK G T R
Sbjct: 407 YFNTALLEMAKANPDVQVHLCMEKLEEYVNFGGVRIESDVLVTKDGVVNYTLVPR 461
>sp|P19213|CREA_FLASU CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|2160260|dbj|BAA03359.1|
(D14464) creatinase [Flavobacterium sp.]
>gi|3410883|dbj|BAA32239.1| (D00656) creatinase
[Flavobacterium sp.] >gi|1097202|prf||2113324B
creatinase [Flavobacterium sp.]
Length = 403
Score = 80.4 bits (195), Expect = 3e-14
Identities = 62/257 (24%), Positives = 115/257 (44%), Gaps = 31/257 (12%)
Query: 112 SEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM 171
+E V MR++KS EE ++I +AD A +E + + E E+A M
Sbjct: 143 AELVDVAAACMRMRMIKSAEEHEMIRHGARVADIGGAAIVEALRDQVPEYEVALHATQAM 202
Query: 172 KMNGAEKPAFDTI--------IASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSD 223
AE FD + SG + H + +++ KGD++ ++ + Y +
Sbjct: 203 VRAIAE--TFDNVELMDTWTWFQSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTA 260
Query: 224 ITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNII--------KEY 275
+ RT+ + ++ +++ +E + ++ +PG+ ++ I + +
Sbjct: 261 LERTLFLDHCSDDHLRMWQANVEVHEAGLKLIKPGMRCSDIAKELNEIFLKHDLLQYRTF 320
Query: 276 GYGDYF---IHSLGHGVGLEIHEWPGVSQYDETVLKEGMVITIEPGIYIPK----FGGVR 328
GYG F H G GLE+ E +TVL+ GMV+++EP I +P+ GG R
Sbjct: 321 GYGHSFGTLSHYYGREAGLELRE------DIDTVLEPGMVVSMEPMIMLPEGRPGAGGYR 374
Query: 329 IEDTIVITKTGARRLTK 345
D +++ + GA +TK
Sbjct: 375 EHDILIVNENGAENITK 391
>gb|AAB82638.1| (AC002387) putative methionine aminopeptidase [Arabidopsis
thaliana] >gi|11320954|gb|AAG33974.1|AF250960_1
(AF250960) methionine aminopeptidase-like protein
[Arabidopsis thaliana]
Length = 398
Score = 80.0 bits (194), Expect = 4e-14
Identities = 63/255 (24%), Positives = 107/255 (41%), Gaps = 49/255 (19%)
Query: 127 VKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKV-EYLMKMNGAEKPA----F 181
+K+ E+I+ + + C+IA + + AA + G EI V E + G P F
Sbjct: 141 IKTPEQIQRMRETCKIAREVLDAAARVIHPGVTTDEIDRVVHEATIAAGGYPSPLNYYFF 200
Query: 182 DTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIY 241
+ + HG+ +++E GD+V +D+ Y + D+ T VG+ +E R++
Sbjct: 201 PKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVCYKGCHGDLNETYFVGNVDEASRQLV 260
Query: 242 EIVLEAQKKAVEAARPGITTKELDSIAR--------NIIKEYGYGDYFIHSLGHGVGLEI 293
+ E +KA+ +PG+ +E+ I ++++ Y GHG+G
Sbjct: 261 KCTYECLEKAIAIVKPGVRFREIGEIVNRHATMSGLSVVRSY---------CGHGIGDLF 311
Query: 294 HEWPGVSQYDET----VLKEGMVITIEPGIYIPKFGGVR--------------------I 329
H P + Y V+K G TIEP I GG R
Sbjct: 312 HCAPNIPHYARNKAVGVMKAGQTFTIEPMI---NAGGWRDRTWPDGWTAVTADGKRSAQF 368
Query: 330 EDTIVITKTGARRLT 344
E T+++T+TG LT
Sbjct: 369 EHTLLVTETGVEVLT 383
>dbj|BAB03321.1| (AB035448) methionin aminopeptidase [Staphylococcus aureus]
Length = 252
Score = 80.0 bits (194), Expect = 4e-14
Identities = 71/252 (28%), Positives = 111/252 (43%), Gaps = 29/252 (11%)
Query: 126 IVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGA-EKPAFDTI 184
IVK++EE++ +++ I K G +E+ + L + GA P D
Sbjct: 2 IVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDEN 61
Query: 185 IAS----GYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVG-SPNEKQRE 239
+ HG+ S + I +GDLV ID+ AL N Y +D + VVG S + +++
Sbjct: 62 FPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQK 121
Query: 240 IYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPG- 298
+ ++ A + A+ +PG + N ++ + GHGVGL +HE P
Sbjct: 122 VCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDL-KVIKNLTGHGVGLSLHEAPAH 180
Query: 299 VSQY----DETVLKEGMVITIEPGI-----------------YIPKFGGVRIEDTIVITK 337
V Y D+T+L EGMV+ IEP I K +IE T+++TK
Sbjct: 181 VLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTK 240
Query: 338 TGARRLTKTERE 349
G TK E E
Sbjct: 241 DGPILTTKIEEE 252
>gb|AAG33976.1|AF250962_1 (AF250962) methionine aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 344
Score = 80.0 bits (194), Expect = 4e-14
Identities = 65/259 (25%), Positives = 115/259 (44%), Gaps = 30/259 (11%)
Query: 113 EFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMK 172
E KV ++ E++I S +K+ +KACE+A + + A V EI V ++
Sbjct: 86 ESSKVPEISSELQIPDSIGIVKM-KKACELAARVLDYAGTLVRPFVTTDEIDKAVHQMVI 144
Query: 173 MNGAEKP-----AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRT 227
GA F + + + HG+ + ++ GD++ ID+ + Y+ D ++T
Sbjct: 145 EFGAYPSPLGYGGFPKSVCTSVNECMFHGIPDSRPLQNGDIINIDVAVYLDGYHGDTSKT 204
Query: 228 VVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGH 287
+ G N +++ ++ E +K + + G + K++ I +YGY +GH
Sbjct: 205 FLCGDVNGSLKQLVKVTEECLEKGISVCKDGASFKQIGKIISEHAAKYGYN--MERFIGH 262
Query: 288 GVGLEIHEWPGV---SQYDETV--LKEGMVITIEPGI---------------YIPKFGG- 326
G+G +H P + S YD + + EG T+EP + + GG
Sbjct: 263 GLGTVLHSEPLIYLHSNYDYELEYMIEGQTFTLEPILTIGTTEFVTWPDKWTIVTADGGP 322
Query: 327 -VRIEDTIVITKTGARRLT 344
+ E TI+IT TGA LT
Sbjct: 323 AAQFEHTILITTTGAEILT 341
>sp|P19994|AMPM_BACSU METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M) >gi|80333|pir||JS0493
methionyl aminopeptidase (EC 3.4.11.18) map - Bacillus
subtilis >gi|216341|dbj|BAA00497.1| (D00619) methionine
amino peptidase [Bacillus subtilis]
>gi|1044986|gb|AAB06821.1| (L47971) methionine
aminopeptidase [Bacillus subtilis]
>gi|2632405|emb|CAB11914.1| (Z99104) methionine
aminopeptidase [Bacillus subtilis]
Length = 248
Score = 79.6 bits (193), Expect = 5e-14
Identities = 68/251 (27%), Positives = 111/251 (44%), Gaps = 33/251 (13%)
Query: 124 MRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP---- 179
M I K+ E+ I+ +A I + + G +E+ E +K GA
Sbjct: 1 MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIAERFIKKQGAIPSFKGY 60
Query: 180 -AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQR 238
F I L HG+ + ++ GD++ ID+GA N Y+ D T VG+ ++ +
Sbjct: 61 NGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGYHGDSAWTYPVGNISDDDK 120
Query: 239 EIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFI---HSLGHGVGLEIHE 295
++ E+ E+ K ++ A+PG + L +I+ + I+ Y + F +GHGVG ++HE
Sbjct: 121 KLLEVTEESLYKGLQEAKPG---ERLSNIS-HAIQTYVENEQFSVVREYVGHGVGQDLHE 176
Query: 296 WPGVSQYDE----TVLKEGMVITIEPGI-----YIPKFGG------------VRIEDTIV 334
P + Y LK GMV+ IEP + Y+ E TI
Sbjct: 177 DPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNWTVVTVDGKKCAHFEHTIA 236
Query: 335 ITKTGARRLTK 345
IT+TG LT+
Sbjct: 237 ITETGFDILTR 247
>pdb|1CHM|B Chain B, Creatine Amidinohydrolase (E.C.3.5.3.3)
Length = 401
Score = 78.0 bits (189), Expect = 1e-13
Identities = 68/295 (23%), Positives = 128/295 (43%), Gaps = 32/295 (10%)
Query: 77 RRDDFYKVFEGV----KVLGIEGS-LSYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDE 131
+RD+++ + + +GIE L+ + L + +E V MR++KS E
Sbjct: 102 QRDNYFAAIQQALPKARRIGIEHDHLNLQNRDKLAARYPDAELVDVAAACMRMRMIKSAE 161
Query: 132 EIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM------KMNGAEKPAFDTII 185
E +I IAD A +E + + E E+A M E T
Sbjct: 162 EHVMIRHGARIADIGGAAVVEALGDQVPEYEVALHATQAMVRAIADTFEDVELMDTWTWF 221
Query: 186 ASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVL 245
SG + H + +++ KGD++ ++ + Y + + RT+ + ++ ++++ +
Sbjct: 222 QSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDDHLRLWQVNV 281
Query: 246 EAQKKAVEAARPGITTKELDSIARNII--------KEYGYGDYF---IHSLGHGVGLEIH 294
E + ++ +PG ++ I + +GYG F H G GLE+
Sbjct: 282 EVHEAGLKLIKPGARCSDIARELNEIFLKHDVLQYRTFGYGHSFGTLSHYYGREAGLELR 341
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPK----FGGVRIEDTIVITKTGARRLTK 345
E +TVL+ GMV+++EP I +P+ GG R D +++ + GA +TK
Sbjct: 342 E------DIDTVLEPGMVVSMEPMIMLPEGLPGAGGYREHDILIVNENGAENITK 390
>sp|P38488|CREA_PSEPU CREATINASE (CREATINE AMIDINOHYDROLASE)
Length = 403
Score = 78.0 bits (189), Expect = 1e-13
Identities = 68/295 (23%), Positives = 128/295 (43%), Gaps = 32/295 (10%)
Query: 77 RRDDFYKVFEGV----KVLGIEGS-LSYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDE 131
+RD+++ + + +GIE L+ + L + +E V MR++KS E
Sbjct: 103 QRDNYFAAIQQALPKARRIGIEHDHLNLQNRDKLAARYPDAELVDVAAACMRMRMIKSAE 162
Query: 132 EIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM------KMNGAEKPAFDTII 185
E +I IAD A +E + + E E+A M E T
Sbjct: 163 EHVMIRHGARIADIGGAAVVEALGDQVPEYEVALHATQAMVRAIADTFEDVELMDTWTWF 222
Query: 186 ASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVL 245
SG + H + +++ KGD++ ++ + Y + + RT+ + ++ ++++ +
Sbjct: 223 QSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDDHLRLWQVNV 282
Query: 246 EAQKKAVEAARPGITTKELDSIARNII--------KEYGYGDYF---IHSLGHGVGLEIH 294
E + ++ +PG ++ I + +GYG F H G GLE+
Sbjct: 283 EVHEAGLKLIKPGARCSDIARELNEIFLKHDVLQYRTFGYGHSFGTLSHYYGREAGLELR 342
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPK----FGGVRIEDTIVITKTGARRLTK 345
E +TVL+ GMV+++EP I +P+ GG R D +++ + GA +TK
Sbjct: 343 E------DIDTVLEPGMVVSMEPMIMLPEGLPGAGGYREHDILIVNENGAENITK 391
>pdb|1CHM|A Chain A, Creatine Amidinohydrolase (E.C.3.5.3.3)
Length = 401
Score = 78.0 bits (189), Expect = 1e-13
Identities = 68/295 (23%), Positives = 128/295 (43%), Gaps = 32/295 (10%)
Query: 77 RRDDFYKVFEGV----KVLGIEGS-LSYSFVEDLKEKGKISEFKKVDDVIKEMRIVKSDE 131
+RD+++ + + +GIE L+ + L + +E V MR++KS E
Sbjct: 102 QRDNYFAAIQQALPKARRIGIEHDHLNLQNRDKLAARYPDAELVDVAAACMRMRMIKSAE 161
Query: 132 EIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLM------KMNGAEKPAFDTII 185
E +I IAD A +E + + E E+A M E T
Sbjct: 162 EHVMIRHGARIADIGGAAVVEALGDQVPEYEVALHATQAMVRAIADTFEDVELMDTWTWF 221
Query: 186 ASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVL 245
SG + H + +++ KGD++ ++ + Y + + RT+ + ++ ++++ +
Sbjct: 222 QSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDDHLRLWQVNV 281
Query: 246 EAQKKAVEAARPGITTKELDSIARNII--------KEYGYGDYF---IHSLGHGVGLEIH 294
E + ++ +PG ++ I + +GYG F H G GLE+
Sbjct: 282 EVHEAGLKLIKPGARCSDIARELNEIFLKHDVLQYRTFGYGHSFGTLSHYYGREAGLELR 341
Query: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPK----FGGVRIEDTIVITKTGARRLTK 345
E +TVL+ GMV+++EP I +P+ GG R D +++ + GA +TK
Sbjct: 342 E------DIDTVLEPGMVVSMEPMIMLPEGLPGAGGYREHDILIVNENGAENITK 390
>pir||C75410 methionine aminopeptidase - Deinococcus radiodurans (strain R1)
>gi|6459062|gb|AAF10883.1|AE001978_3 (AE001978)
methionine aminopeptidase [Deinococcus radiodurans]
Length = 259
Score = 78.0 bits (189), Expect = 1e-13
Identities = 61/249 (24%), Positives = 107/249 (42%), Gaps = 33/249 (13%)
Query: 127 VKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA------ 180
+KS EI+ + +A + + V G +E+ + E ++ GA KPA
Sbjct: 12 LKSAREIETMRRAGGLVAETFRVLEPYVQPGVTLKELDRRAEEFIRGKGA-KPAYLGYGP 70
Query: 181 ----FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEK 236
F I + + HG+ D+ + GD++ +D+G L + Y D T VG +++
Sbjct: 71 RNNPFPGTICASVNEVICHGIPDDRELRDGDILGMDIGVLLDGYYGDACTTYTVGQVSDE 130
Query: 237 QREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEW 296
R + + + ++ RPG T ++ +++ + GYG ++ GHG+G +HE
Sbjct: 131 VRALVDTTRACLQAGLDEVRPGAKTGDIGHAIQSLAESRGYGVVREYT-GHGIGKRLHED 189
Query: 297 PGV----SQYDETVLKEGMVITIEPGIYI-----------------PKFGGVRIEDTIVI 335
P + + L+ GMV TIEP I + K + E T+V+
Sbjct: 190 PTIYHWGVHHTGLKLQPGMVFTIEPMINLGTPETRLLADGWTVITADKKPSAQFEHTLVV 249
Query: 336 TKTGARRLT 344
T G LT
Sbjct: 250 TPKGYDILT 258
>pir||T34903 methionine aminopeptidase - Streptomyces coelicolor
>gi|3218361|emb|CAA19620.1| (AL023861) methionine
aminopeptidase [Streptomyces coelicolor A3(2)]
Length = 258
Score = 77.3 bits (187), Expect = 2e-13
Identities = 67/254 (26%), Positives = 103/254 (40%), Gaps = 34/254 (13%)
Query: 127 VKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP------- 179
+K+D I + A ++ +A+ A + G E+ A +++ GA P
Sbjct: 4 LKTDTSIDAMHAAGQVVARALTAVRQAADVGVSLLELDAVAHEVLREAGAGSPFLGYRPS 63
Query: 180 ----AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNE 235
F +I + A+ HG+ R+ GDLV ID GAL + + D + VVG+P
Sbjct: 64 FAPTPFPGVICASVNDAIVHGIPDGYRLRDGDLVSIDCGALLDGWAGDSALSFVVGTPRP 123
Query: 236 KQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHE 295
+ E A + + AA G ++ + + GYG GHG+G +HE
Sbjct: 124 ADVTLIETAERALEAGIAAAVVGNRIGDIAHAIGTVCRSAGYG-IMEDFGGHGIGRHMHE 182
Query: 296 WPGVSQYDE----TVLKEGMVITIEP---------------GIYIPKFGGVR---IEDTI 333
PGV L+ GMV+ IEP G + G R +E T+
Sbjct: 183 DPGVPNEGRPGRGLPLRHGMVLAIEPMLTAGGRDDYHAAPDGWTLRTNDGSRAAHVEHTV 242
Query: 334 VITKTGARRLTKTE 347
IT G R LT +
Sbjct: 243 AITDGGPRVLTSRD 256
>gb|AAG33975.1|AF250961_1 (AF250961) methionine aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 369
Score = 77.3 bits (187), Expect = 2e-13
Identities = 63/252 (25%), Positives = 111/252 (44%), Gaps = 27/252 (10%)
Query: 119 DVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEK 178
D+ E +I E I + ACE+A + + A V EI V ++ GA
Sbjct: 119 DISSEFQI-PGPEGIAKMRAACELAARVLNYAGTLVKPSVTTNEIDKAVHDMIIEAGAYP 177
Query: 179 P-----AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSP 233
F + + + HG+ ++++ GD++ ID+ + Y+ D +RT G
Sbjct: 178 SPLGYGGFPKSVCTSVNECMCHGIPDSRQLQSGDIINIDVTVYLDGYHGDTSRTFFCGEV 237
Query: 234 NEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEI 293
+E +++ ++ E +K + + G + K++ +++GY + +GHGVG
Sbjct: 238 DEGFKQLVKVTEECLEKGIAVCKDGASFKKIGKRISEHAEKFGY-NVVERFVGHGVGPVF 296
Query: 294 HEWPGVSQY---DETVLKEGMVITIEPGIYI---------------PKFGGV--RIEDTI 333
H P + Y + ++ EG TIEP + I GGV + E TI
Sbjct: 297 HSEPLIYHYRNDEPGLMVEGQTFTIEPILTIGTTECVTWPDNWTTLTADGGVAAQFEHTI 356
Query: 334 VITKTGARRLTK 345
+IT+TG+ LTK
Sbjct: 357 LITRTGSEILTK 368
>sp|P53582|AMP1_HUMAN PUTATIVE METHIONINE AMINOPEPTIDASE 1 (METAP 1) (PEPTIDASE M 1)
(KIAA0094) >gi|577315|dbj|BAA07679.1| (D42084) KIAA0094
gene product is related to S.cerevisiae methionine
aminopeptidase. [Homo sapiens]
Length = 394
Score = 75.3 bits (182), Expect = 1e-12
Identities = 59/243 (24%), Positives = 105/243 (42%), Gaps = 27/243 (11%)
Query: 129 SDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYL-MKMNGAEKPA----FDT 183
S E+I+ + C +A + + A + G EI V + N P F
Sbjct: 140 SSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPK 199
Query: 184 IIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEI 243
+ + HG+ + +++GD+V +D+ N Y+ D+ T VG ++ R++ +
Sbjct: 200 SCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQT 259
Query: 244 VLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD 303
E +A++A +PG+ +EL +I + + G+ + GHG+ H P V Y
Sbjct: 260 TYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSY-CGHGIHKLFHTAPNVPHYA 318
Query: 304 ET----VLKEGMVITIEPGI---------------YIPKFG--GVRIEDTIVITKTGARR 342
+ V+K G V TIEP I + + G + E T+++T TG
Sbjct: 319 KNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEI 378
Query: 343 LTK 345
LT+
Sbjct: 379 LTR 381
>sp|Q9ZCD3|AMPM_RICPR METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435544|pir||A71644 methionine aminopeptidase (map)
RP824 - Rickettsia prowazekii
>gi|3861350|emb|CAA15249.1| (AJ235273) METHIONINE
AMINOPEPTIDASE (map) [Rickettsia prowazekii]
Length = 259
Score = 75.3 bits (182), Expect = 1e-12
Identities = 51/195 (26%), Positives = 86/195 (43%), Gaps = 29/195 (14%)
Query: 181 FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI 240
F I + + HG+ +DK ++ GD+V ID+ + + + D +R VG K + +
Sbjct: 64 FPKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVILDGWYGDTSRMYYVGDVAIKPKRL 123
Query: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYG---DYFIHSLGHGVGLEIHEWP 297
++ +A K +E RPG ++ ++ +++ Y DY GHG+G H+ P
Sbjct: 124 IQVTYDAMMKGIEVVRPGAKLGDIGYAIQSYAEKHNYSVVRDY----TGHGIGRVFHDKP 179
Query: 298 GVSQYDET----VLKEGMVITIEPGI-------YIPKFGG-----------VRIEDTIVI 335
+ Y LKEGM T+EP I + K G + E TI +
Sbjct: 180 SILNYGRNGTGLTLKEGMFFTVEPMINAGNYDTILSKLDGWTVTTRDKSLSAQFEHTIGV 239
Query: 336 TKTGARRLTKTEREL 350
TK G T + ++L
Sbjct: 240 TKDGFEIFTLSPKKL 254
>gb|AAG09564.1|AC011810_23 (AC011810) Putative methionine aminopeptidase [Arabidopsis
thaliana]
Length = 369
Score = 75.3 bits (182), Expect = 1e-12
Identities = 62/252 (24%), Positives = 110/252 (43%), Gaps = 27/252 (10%)
Query: 119 DVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEK 178
D+ E +I E I + ACE+A + + A V EI V ++ GA
Sbjct: 119 DISSEFQI-PGPEGIAKMRAACELAARVLNYAGTLVKPSVTTNEIDKAVHDMIIEAGAYP 177
Query: 179 P-----AFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSP 233
F + + + HG+ ++++ GD++ ID+ + Y+ D +RT G
Sbjct: 178 SPLGYGGFPKSVCTSVNECMCHGIPDSRQLQSGDIINIDVTVYLDGYHGDTSRTFFCGEV 237
Query: 234 NEKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEI 293
+E + + ++ E ++ + + G + K++ +++GY + +GHGVG
Sbjct: 238 DEGFKRLVKVTEECLERGIAVCKDGASFKKIGKRISEHAEKFGY-NVVERFVGHGVGPVF 296
Query: 294 HEWPGVSQY---DETVLKEGMVITIEPGIYI---------------PKFGGV--RIEDTI 333
H P + Y + ++ EG TIEP + I GGV + E TI
Sbjct: 297 HSEPLIYHYRNDEPGLMVEGQTFTIEPILTIGTTECVTWPDNWTTLTADGGVAAQFEHTI 356
Query: 334 VITKTGARRLTK 345
+IT+TG+ LTK
Sbjct: 357 LITRTGSEILTK 368
>gb|AAG33977.1|AF250963_1 (AF250963) methionine aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 350
Score = 74.9 bits (181), Expect = 1e-12
Identities = 56/217 (25%), Positives = 93/217 (42%), Gaps = 26/217 (11%)
Query: 154 VTEGKKEREIAAKVEYLMKMNGAEKP-----AFDTIIASGYRSALPHGVASDKRIEKGDL 208
V G EI V ++ NGA F + + + HG+ + +E GD+
Sbjct: 134 VKPGVTTDEIDEAVHNMIIENGAYPSPLGYGGFPKSVCTSVNECICHGIPDSRPLEDGDI 193
Query: 209 VVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIA 268
+ ID+ N Y+ D + T G+ +EK +++ E+ E+ KA+ PG+ K++ +
Sbjct: 194 INIDVTVYLNGYHGDTSATFFCGNVDEKAKKLVEVTKESLDKAISICGPGVEYKKIGKVI 253
Query: 269 RNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQY---DETVLKEGMVITIEPGIYIPKFG 325
++ ++ YG +GHGVG H P V + + + TIEP + I
Sbjct: 254 HDLADKHKYG-VVRQFVGHGVGSVFHADPVVLHFRNNEAGRMVLNQTFTIEPMLTIGSRN 312
Query: 326 GV-----------------RIEDTIVITKTGARRLTK 345
+ + E TI+ITK GA LTK
Sbjct: 313 PIMWDDNWTVVTEDASLSAQFEHTILITKDGAEILTK 349
>emb|CAB16790.1| (Z99707) methionyl aminopeptidase-like protein [Arabidopsis
thaliana] >gi|7270653|emb|CAB80370.1| (AL161590)
methionyl aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 305
Score = 74.9 bits (181), Expect = 1e-12
Identities = 56/217 (25%), Positives = 93/217 (42%), Gaps = 26/217 (11%)
Query: 154 VTEGKKEREIAAKVEYLMKMNGAEKP-----AFDTIIASGYRSALPHGVASDKRIEKGDL 208
V G EI V ++ NGA F + + + HG+ + +E GD+
Sbjct: 89 VKPGVTTDEIDEAVHNMIIENGAYPSPLGYGGFPKSVCTSVNECICHGIPDSRPLEDGDI 148
Query: 209 VVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTKELDSIA 268
+ ID+ N Y+ D + T G+ +EK +++ E+ E+ KA+ PG+ K++ +
Sbjct: 149 INIDVTVYLNGYHGDTSATFFCGNVDEKAKKLVEVTKESLDKAISICGPGVEYKKIGKVI 208
Query: 269 RNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQY---DETVLKEGMVITIEPGIYIPKFG 325
++ ++ YG +GHGVG H P V + + + TIEP + I
Sbjct: 209 HDLADKHKYG-VVRQFVGHGVGSVFHADPVVLHFRNNEAGRMVLNQTFTIEPMLTIGSRN 267
Query: 326 GV-----------------RIEDTIVITKTGARRLTK 345
+ + E TI+ITK GA LTK
Sbjct: 268 PIMWDDNWTVVTEDASLSAQFEHTILITKDGAEILTK 304
>pir||T50575 methionyl aminopeptidase (EC 3.4.11.18) [imported] - Streptomyces
coelicolor >gi|6469251|emb|CAB61712.1| (AL133220)
methionine aminopeptidase (EC 3.4.11.18). [Streptomyces
coelicolor A3(2)]
Length = 285
Score = 72.6 bits (175), Expect = 6e-12
Identities = 58/244 (23%), Positives = 101/244 (40%), Gaps = 27/244 (11%)
Query: 127 VKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKPA-----F 181
V++ E ++ + A IA +A+ A + + G + M +GA +
Sbjct: 41 VQTPETVEAMRVAGRIAARAMEEAAKHIAPGVTTDALDRVAHEYMCDHGAYPSTLGYRGY 100
Query: 182 DTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIY 241
+ S + HG+ + GD+V +D+ A + D T +VG +E+ R +
Sbjct: 101 PKSLCSSVNEVICHGIPDSTVLRDGDIVNLDVTAYIGGVHGDNNATYLVGEVDEESRLLV 160
Query: 242 EIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQ 301
E E+ +A++A +PG + + + K +GYG GHG+ H V
Sbjct: 161 ERTRESLTRAIKAVKPGRQINIIGRVIESYAKRFGYG-VVRDFTGHGINTSFHSGLIVPH 219
Query: 302 YDE----TVLKEGMVITIEPGIYI-----------------PKFGGVRIEDTIVITKTGA 340
YD TV++ GM TIEP + + + + E T+V+T +GA
Sbjct: 220 YDSPHATTVIQPGMTFTIEPMLTLGTHEYDMWDDGWTVVTKDRRRTAQFEHTLVVTDSGA 279
Query: 341 RRLT 344
LT
Sbjct: 280 EILT 283
>pir||D82097 methionine aminopeptidase VC2261 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9656823|gb|AAF95405.1|
(AE004298) methionine aminopeptidase [Vibrio cholerae]
Length = 280
Score = 72.6 bits (175), Expect = 6e-12
Identities = 50/174 (28%), Positives = 80/174 (45%), Gaps = 27/174 (15%)
Query: 203 IEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVEAARPGITTK 262
+ GD++ ID+ + + Y+ D ++ ++G + + + + + E A++ +PG+
Sbjct: 98 LRDGDILNIDITVIKDGYHGDTSKMFLIGDVSIEDKRLCHVAQECLYLALKQVKPGVQLG 157
Query: 263 ELDSIARNIIKEYGYGD-YFIHSL-----GHGVGLEIHEWPGVSQY---DETVLKEGMVI 313
E+ + IK + F S+ GHG+G E HE P V Y D TVL+EGM+
Sbjct: 158 EIGTTIEKHIKTNNKNNPRFKFSIVRDYCGHGIGAEFHEEPQVVHYKNSDRTVLREGMIF 217
Query: 314 TIEPGIYIPKFG------------------GVRIEDTIVITKTGARRLTKTERE 349
TIEP I KFG + E TI++T TG LT E
Sbjct: 218 TIEPMINAGKFGCRLDDEDSWTVYTADGKKSAQWEHTILVTATGCEILTLRSEE 271
>gb|AAF56327.1| (AE003749) CG13630 gene product [Drosophila melanogaster]
Length = 374
Score = 72.2 bits (174), Expect = 8e-12
Identities = 59/250 (23%), Positives = 106/250 (41%), Gaps = 37/250 (14%)
Query: 127 VKSDEEIKIIEKAC----EIADKAVMAAIEEVTEGKKEREI-AAKVEYLMKMNGAEKPAF 181
V DEEI+ + A E D+ A +T + +R + A +E + F
Sbjct: 117 VLDDEEIEGMRVAGRLGRECLDEGAKAVEVGITTDELDRLVHEAAIERECYPSPLNYYNF 176
Query: 182 DTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIY 241
+ + HG+ + ++ GDL ID+ + ++ D+ T VG+ +EK +++
Sbjct: 177 PKSCCTSVNEVICHGIPDQRPLQDGDLCNIDVTVYHRGFHGDLNETFFVGNVSEKHKKLV 236
Query: 242 EIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQ 301
++ EA KA+E RPG +++ ++ + + +G+ + GHG+ H P V
Sbjct: 237 QVTHEALSKAIEFVRPGEKYRDIGNVIQKYVAPHGFSVVRSY-CGHGIHRVFHTAPNVPH 295
Query: 302 YDET----VLKEGMVITIEP----------------------GIYIPKFGGVRIEDTIVI 335
Y + V+ G TIEP G+Y +F E T+++
Sbjct: 296 YAKNSAVGVMAPGHCFTIEPMISVGVQKAETWPDDWTAVTADGLYSAQF-----EQTLLV 350
Query: 336 TKTGARRLTK 345
+TG LTK
Sbjct: 351 NETGCEILTK 360
>emb|CAA38501.1| (X54687) pepQ product, proline dipeptidase [Escherichia coli]
Length = 646
Score = 71.8 bits (173), Expect = 1e-11
Identities = 69/293 (23%), Positives = 118/293 (39%), Gaps = 65/293 (22%)
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
K V D + R K++ E+ + +A ++A AA E G E +I + YL
Sbjct: 149 KGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDI--NIAYLTATG 206
Query: 175 GAEKPA-FDTIIASGYRSALPHGVASDKRI-EKGDLVVIDLGALYNHYNSDITRTVVVGS 232
+ + I+A +A+ H D + E+ ++D GA YN Y +D+TRT S
Sbjct: 207 HRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKS 266
Query: 233 PNEKQREIYEIVLEAQKKAVEAARPGITTKEL-------------------DSIARNIIK 273
N+ ++ + V + Q + + G++ + D +++
Sbjct: 267 DND-YAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVE 325
Query: 274 EYGYGDYFIHSLGHGVGLEIHEWPGVSQYDE----------------TVLKEGMVITIEP 317
G + H +GH +GL++H+ G Q D +L+ GMV+TIEP
Sbjct: 326 NDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEP 385
Query: 318 GIY-------------------------IPKFGGVRIEDTIVITKTGARRLTK 345
GIY + FGG+RIED +VI + +T+
Sbjct: 386 GIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTR 438
>pir||S30738 X-Pro dipeptidase (EC 3.4.13.9) - Escherichia coli
>gi|148247|gb|AAA67644.1| (M87049) proline dipeptidase
[Escherichia coli]
Length = 443
Score = 71.8 bits (173), Expect = 1e-11
Identities = 69/293 (23%), Positives = 118/293 (39%), Gaps = 65/293 (22%)
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
K V D + R K++ E+ + +A ++A AA E G E +I + YL
Sbjct: 149 KGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDI--NIAYLTATG 206
Query: 175 GAEKPA-FDTIIASGYRSALPHGVASDKRI-EKGDLVVIDLGALYNHYNSDITRTVVVGS 232
+ + I+A +A+ H D + E+ ++D GA YN Y +D+TRT S
Sbjct: 207 HRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKS 266
Query: 233 PNEKQREIYEIVLEAQKKAVEAARPGITTKEL-------------------DSIARNIIK 273
N+ ++ + V + Q + + G++ + D +++
Sbjct: 267 DND-YAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVE 325
Query: 274 EYGYGDYFIHSLGHGVGLEIHEWPGVSQYDE----------------TVLKEGMVITIEP 317
G + H +GH +GL++H+ G Q D +L+ GMV+TIEP
Sbjct: 326 NDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEP 385
Query: 318 GIY-------------------------IPKFGGVRIEDTIVITKTGARRLTK 345
GIY + FGG+RIED +VI + +T+
Sbjct: 386 GIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTR 438
>sp|P21165|PEPQ_ECOLI XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE) >gi|7466975|pir||H65189
X-Pro dipeptidase (EC 3.4.13.9) - Escherichia coli
(strain K-12) >gi|1790282|gb|AAC76850.1| (AE000460)
proline dipeptidase [Escherichia coli K12]
Length = 443
Score = 71.8 bits (173), Expect = 1e-11
Identities = 69/293 (23%), Positives = 118/293 (39%), Gaps = 65/293 (22%)
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
K V D + R K++ E+ + +A ++A AA E G E +I + YL
Sbjct: 149 KGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDI--NIAYLTATG 206
Query: 175 GAEKPA-FDTIIASGYRSALPHGVASDKRI-EKGDLVVIDLGALYNHYNSDITRTVVVGS 232
+ + I+A +A+ H D + E+ ++D GA YN Y +D+TRT S
Sbjct: 207 HRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKS 266
Query: 233 PNEKQREIYEIVLEAQKKAVEAARPGITTKEL-------------------DSIARNIIK 273
N+ ++ + V + Q + + G++ + D +++
Sbjct: 267 DND-YAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVE 325
Query: 274 EYGYGDYFIHSLGHGVGLEIHEWPGVSQYDE----------------TVLKEGMVITIEP 317
G + H +GH +GL++H+ G Q D +L+ GMV+TIEP
Sbjct: 326 NDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEP 385
Query: 318 GIY-------------------------IPKFGGVRIEDTIVITKTGARRLTK 345
GIY + FGG+RIED +VI + +T+
Sbjct: 386 GIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTR 438
>sp|P07906|AMPM_ECOLI METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M) >gi|67532|pir||DPECM
methionyl aminopeptidase (EC 3.4.11.18) [validated] -
Escherichia coli >gi|494313|pdb|1MAT| Methionine
Aminopeptidase (E.C.3.4.11.18) >gi|146727|gb|AAA24112.1|
(M15106) methionine amino peptidase [Escherichia coli]
>gi|473823|dbj|BAA05612.1| (D26562) 'methionine
aminopeptidase' [Escherichia coli]
>gi|1552745|gb|AAB08597.1| (U70214) methionine
aminopeptidase [Escherichia coli]
>gi|1786364|gb|AAC73279.1| (AE000126) methionine
aminopeptidase [Escherichia coli K12]
Length = 264
Score = 71.4 bits (172), Expect = 1e-11
Identities = 50/179 (27%), Positives = 79/179 (43%), Gaps = 23/179 (12%)
Query: 195 HGVASDKRIEK-GDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVE 253
HG+ D ++ K GD+V ID+ + + ++ D ++ +VG P + I E+ A+
Sbjct: 79 HGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALR 138
Query: 254 AARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD----ETVLKE 309
+PGI +E+ + + ++ G+ GHG+G HE P V YD VLK
Sbjct: 139 MVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKP 197
Query: 310 GMVITIEPGIYIPKFG-----------------GVRIEDTIVITKTGARRLTKTERELI 351
GM TIEP + K + E TIV+T G LT + + I
Sbjct: 198 GMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTI 256
>pdb|2MAT|A Chain A, E.Coli Methionine Aminopeptidase At 1.9 Angstrom
Resolution
Length = 264
Score = 71.4 bits (172), Expect = 1e-11
Identities = 50/179 (27%), Positives = 79/179 (43%), Gaps = 23/179 (12%)
Query: 195 HGVASDKRIEK-GDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVE 253
HG+ D ++ K GD+V ID+ + + ++ D ++ +VG P + I E+ A+
Sbjct: 79 HGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALR 138
Query: 254 AARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD----ETVLKE 309
+PGI +E+ + + ++ G+ GHG+G HE P V YD VLK
Sbjct: 139 MVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKP 197
Query: 310 GMVITIEPGIYIPKFG-----------------GVRIEDTIVITKTGARRLTKTERELI 351
GM TIEP + K + E TIV+T G LT + + I
Sbjct: 198 GMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTI 256
>pdb|1C22|A Chain A, E. Coli Methionine Aminopeptidase: Trifluoromethionine
Complex >gi|6573514|pdb|1C23|A Chain A, E. Coli
Methionine Aminopeptidase: Methionine Phosphonate
Complex >gi|6573515|pdb|1C24|A Chain A, E. Coli
Methionine Aminopeptidase: Methionine Phosphinate
Complex >gi|6573394|pdb|1C27|A Chain A, E. Coli
Methionine Aminopeptidase:norleucine Phosphonate Complex
>gi|6573512|pdb|1C21|A Chain A, E. Coli Methionine
Aminopeptidase: Methionine Complex
Length = 263
Score = 71.4 bits (172), Expect = 1e-11
Identities = 50/179 (27%), Positives = 79/179 (43%), Gaps = 23/179 (12%)
Query: 195 HGVASDKRIEK-GDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVE 253
HG+ D ++ K GD+V ID+ + + ++ D ++ +VG P + I E+ A+
Sbjct: 78 HGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALR 137
Query: 254 AARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD----ETVLKE 309
+PGI +E+ + + ++ G+ GHG+G HE P V YD VLK
Sbjct: 138 MVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKP 196
Query: 310 GMVITIEPGIYIPKFG-----------------GVRIEDTIVITKTGARRLTKTERELI 351
GM TIEP + K + E TIV+T G LT + + I
Sbjct: 197 GMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTI 255
>pdb|3MAT|A Chain A, E.Coli Methionine Aminopeptidase Transition-State
Inhibitor Complex
Length = 265
Score = 71.4 bits (172), Expect = 1e-11
Identities = 50/179 (27%), Positives = 79/179 (43%), Gaps = 23/179 (12%)
Query: 195 HGVASDKRIEK-GDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVE 253
HG+ D ++ K GD+V ID+ + + ++ D ++ +VG P + I E+ A+
Sbjct: 79 HGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALR 138
Query: 254 AARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD----ETVLKE 309
+PGI +E+ + + ++ G+ GHG+G HE P V YD VLK
Sbjct: 139 MVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKP 197
Query: 310 GMVITIEPGIYIPKFG-----------------GVRIEDTIVITKTGARRLTKTERELI 351
GM TIEP + K + E TIV+T G LT + + I
Sbjct: 198 GMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTI 256
>pdb|4MAT|A Chain A, E.Coli Methionine Aminopeptidase His79ala Mutant
Length = 278
Score = 71.4 bits (172), Expect = 1e-11
Identities = 50/179 (27%), Positives = 79/179 (43%), Gaps = 23/179 (12%)
Query: 195 HGVASDKRIEK-GDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEAQKKAVE 253
HG+ D ++ K GD+V ID+ + + ++ D ++ +VG P + I E+ A+
Sbjct: 79 HGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALR 138
Query: 254 AARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGVSQYD----ETVLKE 309
+PGI +E+ + + ++ G+ GHG+G HE P V YD VLK
Sbjct: 139 MVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKP 197
Query: 310 GMVITIEPGIYIPKFG-----------------GVRIEDTIVITKTGARRLTKTERELI 351
GM TIEP + K + E TIV+T G LT + + I
Sbjct: 198 GMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTI 256
>sp|P53581|AMP3_SYNY3 PUTATIVE METHIONINE AMINOPEPTIDASE C (MAP) (PEPTIDASE M)
>gi|7435548|pir||S75743 methionyl aminopeptidase (EC
3.4.11.18) 3 - Synechocystis sp. (strain PCC 6803)
>gi|1001237|dbj|BAA10478.1| (D64003) methionine
aminopeptidase [Synechocystis sp.]
Length = 305
Score = 71.0 bits (171), Expect = 2e-11
Identities = 62/253 (24%), Positives = 103/253 (40%), Gaps = 31/253 (12%)
Query: 127 VKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAEKP-----AF 181
+K+ EI I+ +A IA + + V G ++ E ++ GA F
Sbjct: 56 IKTPAEIAIMRQAGAIAAQVLKEIAATVQPGMTTGDLDQLAEERIRSLGATPSFKGYHGF 115
Query: 182 DTIIASGYRSALPHGVASD-KRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPNEKQREI 240
I + + + HG+ K+I GDL+ +D GA + Y+ D T+ VG + + + +
Sbjct: 116 PASICACVNNEVVHGIPRRRKKIRSGDLLKVDTGAYFQGYHGDSCITIAVGKVSPQAQRL 175
Query: 241 YEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIHEWPGV- 299
E+ A +E +PG ++ + +K GY GHGVG +HE P V
Sbjct: 176 MEVAEGALYAGIEQVKPGNYLMDIAGAIEDYVKPTGY-TIVEEFTGHGVGQALHEDPHVF 234
Query: 300 ----SQYDETVLKEGMVITIEP-----------------GIYIPKFGGVRIEDTIVITKT 338
LK GM + IEP + + + E T+++T T
Sbjct: 235 NVRCRDLPNVKLKPGMTLAIEPIVNAGSRFTRTLGDRWTVVTVDNALSAQFEHTVLVTAT 294
Query: 339 GARRLTKTERELI 351
G L T+R L+
Sbjct: 295 GYELL--TDRRLV 305
>gi|6323273 methionine aminopeptidase; Map1p [Saccharomyces cerevisiae]
>gi|1351928|sp|Q01662|AMP1_YEAST METHIONINE
AMINOPEPTIDASE 1 PRECURSOR (METAP 1) (PEPTIDASE M 1)
(MAP) >gi|1363808|pir||S59390 methionyl aminopeptidase
(EC 3.4.11.18) MAP1 precursor - yeast (Saccharomyces
cerevisiae) >gi|662342|gb|AAB67398.1| (U20865) Map1p:
methionine aminopeptidase [Saccharomyces cerevisiae]
>gi|975723|gb|AAA75193.1| (M77092) methionine
aminopeptidase I [Saccharomyces cerevisiae]
Length = 387
Score = 69.9 bits (168), Expect = 4e-11
Identities = 62/220 (28%), Positives = 95/220 (43%), Gaps = 28/220 (12%)
Query: 118 DDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMNGAE 177
+D + + I K D+ IK I KAC + + + A V G E+ V GA
Sbjct: 121 NDRLNNIPIYKKDQ-IKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAY 179
Query: 178 KPA-----FDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGS 232
F + + + HGV +++GD+V +D+ Y Y++D+ T VG
Sbjct: 180 PSPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGE 239
Query: 233 PNEKQR-EIYEIVLEAQKKAVEAARPGITTKEL-DSIAR-------NIIKEYGYGDYFIH 283
K+ E E K A++ +PG T +EL D I + ++++ Y
Sbjct: 240 NISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTY-------- 291
Query: 284 SLGHGVGLEIHEWPGVSQYDET----VLKEGMVITIEPGI 319
GHGVG H P + Y + V+K GMV TIEP I
Sbjct: 292 -CGHGVGEFFHCSPNIPHYAKNRTPGVMKPGMVFTIEPMI 330
>gi|6322999 Yll029wp [Saccharomyces cerevisiae] >gi|2131729|pir||S64780
hypothetical protein YLL029w - yeast (Saccharomyces
cerevisiae) >gi|1360212|emb|CAA97478.1| (Z73134) ORF
YLL029w [Saccharomyces cerevisiae]
Length = 749
Score = 69.9 bits (168), Expect = 4e-11
Identities = 68/255 (26%), Positives = 121/255 (46%), Gaps = 28/255 (10%)
Query: 105 LKEKGKISEFKKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVM----AAIEEVTEGKK- 159
+ +K F + I ++ +K+D EIK KA ++ D + A +E+ G++
Sbjct: 433 IAKKMTAQNFAIIHSPIDVLKSIKNDIEIKNAHKA-QVKDAVCLVQYFAWLEQQLVGREA 491
Query: 160 ---EREIAAKVEYLMK-MNGAEKPAFDTIIASGYRSALPH---GVASDKRIEKGDLVVID 212
E A K+ + K +F+TI ++G +A+ H V + I+ + + D
Sbjct: 492 LIDEYRAAEKLTEIRKTQRNFMGNSFETISSTGSNAAIIHYSPPVENSSMIDPTKIYLCD 551
Query: 213 LGALYNHYNSDITRTVVVGSPNEKQREIYEIVLEA----QKKAVEAARPGITTKELDSIA 268
G+ + +DITRT+ + P +++ + Y +VL+ ++ PG +D+IA
Sbjct: 552 SGSQFLEGTTDITRTIHLTKPTKEEMDNYTLVLKGGLALERLIFPENTPGF---NIDAIA 608
Query: 269 RNIIKEYGYGDYFIHSLGHGVG--LEIHEWP-GVSQYDETV---LKEGMVITIEPGIYIP 322
R + + G + H GHG+G L +HE P GV + L+ G +I+ EPG Y
Sbjct: 609 RQFL--WSRGLDYKHGTGHGIGSFLNVHEGPMGVGFRPHLMNFPLRAGNIISNEPGYYKD 666
Query: 323 KFGGVRIEDTIVITK 337
G+RIE ++I K
Sbjct: 667 GEYGIRIESDMLIKK 681
>gb|AAF33408.1| (AF233324) 95% identity with E. coli proline dipeptidase (PEPQ);
contains similarity to Pfam family PF0055
(metallopeptidase family M24), score=346.7, E=2.6e-100,
N=1 [Salmonella typhimurium LT2]
Length = 443
Score = 69.9 bits (168), Expect = 4e-11
Identities = 70/293 (23%), Positives = 116/293 (38%), Gaps = 65/293 (22%)
Query: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
K V D + R K+D E+ + +A ++A AA E G E +I + YL
Sbjct: 149 KGVIDYLHYYRAYKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDI--NLAYLTATG 206
Query: 175 GAEKPA-FDTIIASGYRSALPHGVASDKRI-EKGDLVVIDLGALYNHYNSDITRTVVVGS 232
+ + I+A +A+ H D + + ++D GA YN Y +D+TRT S
Sbjct: 207 HRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEMRSFLLDAGAEYNGYAADLTRTWSAKS 266
Query: 233 PNEKQREIYEIVLEAQKKAVEAARPGITTKEL-------------------DSIARNIIK 273
N+ + + V + Q + + G++ + D +++
Sbjct: 267 DNDYAHLVKD-VNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVE 325
Query: 274 EYGYGDYFIHSLGHGVGLEIHEWPGVSQYDE----------------TVLKEGMVITIEP 317
G + H +GH +GL++H+ G Q D VL+ MV+TIEP
Sbjct: 326 NDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEP 385
Query: 318 GIY-------------------------IPKFGGVRIEDTIVITKTGARRLTK 345
GIY + FGG+RIED +VI + G +T+
Sbjct: 386 GIYFIESLLAPWREGPFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTR 438
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.315 0.137 0.374
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 127185530
Number of Sequences: 2977
Number of extensions: 5538638
Number of successful extensions: 14554
Number of sequences better than 1.0e-10: 164
Number of HSP's better than 0.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 14121
Number of HSP's gapped (non-prelim): 199
length of query: 351
length of database: 189,106,746
effective HSP length: 60
effective length of query: 291
effective length of database: 153,197,526
effective search space: 44580480066
effective search space used: 44580480066
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 165 (68.7 bits)