BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1659 (mtaP-like) DE:methylthioadenosine phosphorylase
related (mtaP)
(265 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||D75085 methylthioadenosine phosphorylase related (mtap) PAB... 541 e-153
pir||A71056 probable 5'-methylthioadenosine phosphorylase - Pyro... 511 e-144
pir||C70351 purine nucleoside phosphorylase - Aquifex aeolicus >... 270 2e-71
pir||H75199 methylthioadenosine phosphorylase (mtap) PAB2264 - P... 264 1e-69
pir||A69080 methylthioadenosine phosphorylase - Methanobacterium... 261 5e-69
sp|O57865|Y125_PYRHO HYPOTHETICAL PROTEIN PH0125 >gi|7450057|pir... 261 8e-69
emb|CAC11476.1| (AL445064) purine-nucleoside phosphorylase relat... 243 2e-63
gb|AAK42494.1| 5'-methylthioadenosine phosphorylase (mtaP) [Sulf... 228 8e-59
sp|Q60367|Y060_METJA HYPOTHETICAL PROTEIN MJ0060 >gi|2127724|pir... 224 1e-57
pir||E72575 probable 5'-methylthioadenosine phosphorylase APE188... 214 1e-54
emb|CAB90972.1| (AL355832) putative methylthioadenosine phosphor... 209 2e-53
pdb|1CG6|A Chain A, Structure Of Human 5'-Deoxy-5'-Methylthioade... 195 5e-49
gi|4505273 5'-methylthioadenosine phosphorylase [Homo sapiens] >... 194 7e-49
gb|AAG38871.1|L40432_1 (L40432) methylthioadenosine phosphorylas... 194 1e-48
pir||F83270 probable nucleoside phosphorylase PA3004 [imported] ... 189 2e-47
pir||B70546 probable pnp protein - Mycobacterium tuberculosis (s... 180 2e-44
gb|AAF57869.1| (AE003803) CG4802 gene product [Drosophila melano... 180 2e-44
pir||H82568 purine nucleoside phosphorylase XF2353 [imported] - ... 180 2e-44
pir||S76441 hypothetical protein - Synechocystis sp. (strain PCC... 177 1e-43
sp|Q09438|MTAP_CAEEL PUTATIVE 5'-METHYLTHIOADENOSINE PHOSPHORYLA... 174 1e-42
emb|CAB75631.1| (AL157415) 5'-methylthioadenosine phosphorylase ... 153 1e-36
gi|11499377 methylthioadenosine phosphorylase (mtaP) [Archaeoglo... 139 3e-32
sp|Q09816|YAC2_SCHPO HYPOTHETICAL 33.9 KD PROTEIN C16C9.02C IN C... 138 7e-32
emb|CAA62156.1| (X90564) orf [Saccharomyces cerevisiae] 136 2e-31
gi|6323045 regulator of ADH2 expression; Meu1p [Saccharomyces ce... 136 3e-31
emb|CAB61871.1| (AL133252) putative phosphorylase [Streptomyces ... 134 1e-30
sp|P23139|YPE2_RHORU HYPOTHETICAL 25.8 KD PROTEIN IN PETC 3'REGI... 108 8e-23
sp|P77834|PUNA_BACST PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (... 104 1e-21
sp|P46354|PUNA_BACSU PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (... 100 2e-20
dbj|BAB05250.1| (AP001512) purine nucleoside phosphorylase [Baci... 100 3e-20
dbj|BAB05251.1| (AP001512) purine nucleoside phosphorylase [Baci... 98 9e-20
sp|P45563|XAPA_ECOLI XANTHOSINE PHOSPHORYLASE >gi|7433918|pir||F... 96 3e-19
gb|AAD19641.1| (AF109294) hypothetical methylthioadenosine phosp... 96 6e-19
pir||H72217 purine nucleoside phosphorylase - Thermotoga maritim... 96 6e-19
pir||H72233 purine nucleoside phosphorylase - Thermotoga maritim... 95 1e-18
pdb|1QE5|A Chain A, Purine Nucleoside Phosphorylase From Cellulo... 86 4e-16
pdb|1PBN| Purine Nucleoside Phosphorylase >gi|4699623|pdb|4PNP... 84 1e-15
pdb|1A9T| Bovine Purine Nucleoside Phosphorylase Complexed Wit... 84 1e-15
pdb|1A9P| Bovine Purine Nucleoside Phosphorylase Complexed Wit... 84 1e-15
pir||S66203 purine-nucleoside phosphorylase (EC 2.4.2.1) - bovin... 84 2e-15
sp|P55859|PNPH_BOVIN PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PH... 84 2e-15
pdb|1B8O|A Chain A, Purine Nucleoside Phosphorylase >gi|4558113|... 84 2e-15
pdb|1FXU|A Chain A, Purine Nucleoside Phosphorylase From Calf Sp... 84 2e-15
gi|7305395 purine-nucleoside phopshorylase [Mus musculus] >gi|53... 83 2e-15
gb|AAC37635.1| (L11291) purine nucleoside phosphorylase [Mus mus... 83 2e-15
pdb|1VFN| Purine Nucleoside Phosphorylase 83 2e-15
sp|P23492|PNPH_MOUSE PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PH... 83 3e-15
sp|O53359|PUNA_MYCTU PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PH... 83 3e-15
sp|P46862|PUNA_MYCLE PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PH... 82 5e-15
pir||I76672 purine-nucleoside phosphorylase (EC 2.4.2.1) - weste... 82 9e-15
pdb|1A9Q| Bovine Purine Nucleoside Phosphorylase Complexed Wit... 81 1e-14
emb|CAA52049.1| (X73828) xanthosine phosphorylase [Escherichia c... 80 3e-14
gi|4557801 purine nucleoside phosphorylase [Homo sapiens] >gi|13... 78 1e-13
gb|AAA36460.1| (M13953) purine nucleoside phosphorylase [Homo sa... 78 1e-13
gi|11437430 purine nucleoside phosphorylase [Homo sapiens] 78 1e-13
gb|AAF47653.1| (AE003475) CG16758 gene product [alt 4] [Drosophi... 77 2e-13
gb|AAF47654.1| (AE003475) CG16758 gene product [alt 3] [Drosophi... 77 2e-13
gb|AAF47655.1| (AE003475) CG16758 gene product [alt 2] [Drosophi... 77 2e-13
gb|AAF47656.1| (AE003475) CG16758 gene product [alt 1] [Drosophi... 77 2e-13
pir||T37901 probable purine nucleoside phosphorylase - fission y... 73 3e-12
pir||A42708 purine-nucleoside phosphorylase (EC 2.4.2.1) - Bacil... 69 5e-11
gi|6323238 Purine Nucleoside Phosphorylase; Pnp1p [Saccharomyces... 69 7e-11
>pir||D75085 methylthioadenosine phosphorylase related (mtap) PAB1659 -
Pyrococcus abyssi (strain Orsay)
>gi|5458497|emb|CAB49985.1| (AJ248286)
methylthioadenosine phosphorylase related (mtaP)
[Pyrococcus abyssi]
Length = 265
Score = 541 bits (1380), Expect = e-153
Identities = 265/265 (100%), Positives = 265/265 (100%)
Query: 1 MVRVAVIGGSGVYDFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHK 60
MVRVAVIGGSGVYDFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHK
Sbjct: 1 MVRVAVIGGSGVYDFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHK 60
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESP 120
INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESP
Sbjct: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESP 120
Query: 121 HDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRIL 180
HDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRIL
Sbjct: 121 HDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRIL 180
Query: 181 GGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVAL 240
GGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVAL
Sbjct: 181 GGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVAL 240
Query: 241 ITKAIPLIPKERNCPCKDALKGATG 265
ITKAIPLIPKERNCPCKDALKGATG
Sbjct: 241 ITKAIPLIPKERNCPCKDALKGATG 265
>pir||A71056 probable 5'-methylthioadenosine phosphorylase - Pyrococcus
horikoshii >gi|3257560|dbj|BAA30243.1| (AP000005) 265aa
long hypothetical 5'-methylthioadenosine phosphorylase
[Pyrococcus horikoshii]
Length = 265
Score = 511 bits (1303), Expect = e-144
Identities = 243/265 (91%), Positives = 258/265 (96%)
Query: 1 MVRVAVIGGSGVYDFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHK 60
MVRVAVIGGSGVYDFPAENKR +TVETPYGKV +TIG V GEEVAFLARHGKGHS+PPHK
Sbjct: 1 MVRVAVIGGSGVYDFPAENKRELTVETPYGKVNLTIGHVAGEEVAFLARHGKGHSVPPHK 60
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESP 120
+NYRANIWAL+ELGVERI+ATSAVGS+NPNMRPGDFVILDQ+IDFTVSRPRTFYDGEESP
Sbjct: 61 VNYRANIWALHELGVERIVATSAVGSLNPNMRPGDFVILDQLIDFTVSRPRTFYDGEESP 120
Query: 121 HDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRIL 180
HDRKFVAHVDFTEPYCPEIRRALI AAK+LSLPYHP+GTYVCTEGPRFETAAEI+AYRIL
Sbjct: 121 HDRKFVAHVDFTEPYCPEIRRALITAAKDLSLPYHPKGTYVCTEGPRFETAAEIRAYRIL 180
Query: 181 GGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVAL 240
GGDVVGMTQCPEA LARELE+CYATVAIVTNYAAGISGKKLTH+EVVELMNKK++EI AL
Sbjct: 181 GGDVVGMTQCPEAALARELEMCYATVAIVTNYAAGISGKKLTHAEVVELMNKKTREITAL 240
Query: 241 ITKAIPLIPKERNCPCKDALKGATG 265
ITKAIPLIPKERNCPCKDALKGATG
Sbjct: 241 ITKAIPLIPKERNCPCKDALKGATG 265
>pir||C70351 purine nucleoside phosphorylase - Aquifex aeolicus
>gi|2983202|gb|AAC06801.1| (AE000696) purine nucleoside
phosphorylase [Aquifex aeolicus]
Length = 277
Score = 270 bits (682), Expect = 2e-71
Identities = 133/274 (48%), Positives = 188/274 (68%), Gaps = 14/274 (5%)
Query: 4 VAVIGGSGVYDFPA-ENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPPHK 60
+ +IGGSG+Y+ P + K V V+TP+G+ V I V G++VAFLARHG+GH PPH
Sbjct: 2 LGIIGGSGLYNLPGIKVKEEVQVKTPFGEPSSPVVIAEVEGKKVAFLARHGRGHEYPPHL 61
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESP 120
+ YRAN+WAL E+GV+R++ SAVG +N + PGDFV++ +DFT +R T+Y+G+ S
Sbjct: 62 VPYRANLWALREVGVKRVLGISAVGGINELLMPGDFVVIHDYLDFTKTRRSTYYEGKFSV 121
Query: 121 ----HDRKF-------VAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFE 169
D+ V HVD +E YCPE+R+ LI KE + +HP+G Y CTEGPRFE
Sbjct: 122 KVEGEDKVAKLLREGKVVHVDMSEAYCPEMRKVLIQILKEKNFRFHPKGVYACTEGPRFE 181
Query: 170 TAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVEL 229
T +EIK ++LG DVVGMT PE LAREL +CYA++ +V N AAGI+G +LT +EV++L
Sbjct: 182 TPSEIKMLKLLGADVVGMTGYPEVALARELTMCYASLCVVANPAAGIAGYRLTSNEVIQL 241
Query: 230 MNKKSKEIVALITKAIPLIPKERNCPCKDALKGA 263
M +K +EI ++ K I +P+ R+C C+ +L+GA
Sbjct: 242 MKRKEEEIKEVVLKFIKELPEIRSCDCEKSLEGA 275
>pir||H75199 methylthioadenosine phosphorylase (mtap) PAB2264 - Pyrococcus
abyssi (strain Orsay) >gi|5457556|emb|CAB49047.1|
(AJ248283) methylthioadenosine phosphorylase (mtaP)
[Pyrococcus abyssi]
Length = 257
Score = 264 bits (667), Expect = 1e-69
Identities = 135/263 (51%), Positives = 172/263 (65%), Gaps = 12/263 (4%)
Query: 1 MVRVAVIGGSGVYDFPAENKRSVTVETPYGK--VEVTIGLVNGEEVAFLARHGKGHSIPP 58
M ++ +IGGSGVY E K V + TPYG+ V IG + G EVAF+ RHGK H PP
Sbjct: 1 MPKIGIIGGSGVYGV-FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPP 59
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
H++ YRANIWALYELGVERIIA +AVGS+ +PGD VI+DQ IDFT R TFY+G +
Sbjct: 60 HEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK 119
Query: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
VAHV +P+CPE+RR I AKEL LP H +GTY+C EGPRF T AE + +R
Sbjct: 120 -------VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFR 172
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIV 238
DV+GMT PE LAREL +CY ++ VT+Y + K + EV+ +M + +++
Sbjct: 173 QF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRVMKENEEKVQ 230
Query: 239 ALITKAIPLIPKERNCPCKDALK 261
L+ KAIP IP+ER C C D LK
Sbjct: 231 KLLRKAIPKIPEERKCGCADVLK 253
>pir||A69080 methylthioadenosine phosphorylase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622720|gb|AAB86069.1| (AE000919)
methylthioadenosine phosphorylase [Methanobacterium
thermoautotrophicum]
Length = 280
Score = 261 bits (661), Expect = 5e-69
Identities = 132/263 (50%), Positives = 179/263 (67%), Gaps = 16/263 (6%)
Query: 4 VAVIGGSGVYDFPAENK--RSVTVETPYGKV-EVTIGLVNGEEVAFLARHGKGHSIPPHK 60
+ +IGG+G+Y+ + R ++ TPYGK E+++ ++G VAF+ RH GH PPH
Sbjct: 2 IGIIGGTGIYEMAEYGRLERRGSLITPYGKTPEISVFKLHGRRVAFIPRHSPGHDKPPHM 61
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESP 120
+NYRANIWAL ELGV +IIAT+AVGS+ ++ PGDFV+ +DFT SRP TFYD +
Sbjct: 62 VNYRANIWALKELGVRQIIATNAVGSLKRSIGPGDFVVPHDFLDFTRSRPSTFYDEK--- 118
Query: 121 HDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRIL 180
HVD TEPYC IR AL ++ + G YVCTEGPRFET AEI+ ++ L
Sbjct: 119 -----TVHVDMTEPYCRNIRSALSGSSGVVD-----GGVYVCTEGPRFETPAEIRMFQTL 168
Query: 181 GGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVAL 240
GG VVGMT PEA+LARELE+CYA++ +V+NYAA IS KLT EV E+M++K +++ +
Sbjct: 169 GGTVVGMTGLPEAVLARELEMCYASICLVSNYAASISPSKLTIDEVFEIMDEKKNDLIDI 228
Query: 241 ITKAIPLIPKERNCPCKDALKGA 263
I AI + E++CPC+ AL+GA
Sbjct: 229 IDAAIRDLKTEQSCPCQHALRGA 251
>sp|O57865|Y125_PYRHO HYPOTHETICAL PROTEIN PH0125 >gi|7450057|pir||C71233 probable
5'-methylthioadenosine phosphorylase - Pyrococcus
horikoshii >gi|3256511|dbj|BAA29194.1| (AP000001) 260aa
long hypothetical 5'-methylthioadenosine phosphorylase
[Pyrococcus horikoshii]
Length = 260
Score = 261 bits (659), Expect = 8e-69
Identities = 133/263 (50%), Positives = 173/263 (65%), Gaps = 12/263 (4%)
Query: 1 MVRVAVIGGSGVYDFPAENKRSVTVETPYGK--VEVTIGLVNGEEVAFLARHGKGHSIPP 58
M ++ +IGGSGVY E K V V TPYG+ + IG + G EVAF+ RHGK H PP
Sbjct: 4 MPKIGIIGGSGVYGV-FEPKEVVKVHTPYGRPSAPIEIGEIEGVEVAFIPRHGKYHEFPP 62
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
H++ YRANIWAL+ELGVER+IA +AVGS+ +PGD VI+DQ IDFT R TFY+G +
Sbjct: 63 HQVPYRANIWALHELGVERVIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK 122
Query: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
VAHV +P+CPE+R+ I AKEL+LP H RGTYVC EGPRF T AE + +R
Sbjct: 123 -------VAHVSMADPFCPELRKIFIETAKELNLPVHERGTYVCIEGPRFSTRAESRMFR 175
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIV 238
DV+GMT PE LAREL +CY ++ VT+Y + K + EV+ +M + +++
Sbjct: 176 QF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVDAQEVLRVMKENEEKVQ 233
Query: 239 ALITKAIPLIPKERNCPCKDALK 261
L+ +AIP IP+ER C C D LK
Sbjct: 234 KLLKRAIPKIPEERKCGCADVLK 256
>emb|CAC11476.1| (AL445064) purine-nucleoside phosphorylase related protein
[Thermoplasma acidophilum]
Length = 261
Score = 243 bits (614), Expect = 2e-63
Identities = 127/265 (47%), Positives = 167/265 (62%), Gaps = 12/265 (4%)
Query: 1 MVRVAVIGGSGVYDFPAENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPP 58
M + +IGGSG+YD E+ + V +ETP+G V IG VNG EVAFL RHGK H+IPP
Sbjct: 5 MAYIGIIGGSGLYDLMPESTKKV-IETPFGNPSDAVEIGEVNGVEVAFLPRHGKKHTIPP 63
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
HK+NYRANIWAL+ELGVERII +AVGS+ + +PG+ VI DQ IDFT R TFYDG +
Sbjct: 64 HKVNYRANIWALHELGVERIIGLNAVGSLREDYKPGEIVIPDQYIDFTKRRDLTFYDGPQ 123
Query: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
V H+ +P+CPE+ L A+ L +P H GTY+ EGPRF T AE K +R
Sbjct: 124 -------VYHISEADPFCPEMNSILYDTARNLKIPVHNSGTYITIEGPRFSTRAESKMFR 176
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIV 238
D++GMT PE LA EL +CY+ +A +T+Y S K + EV+ +M + ++
Sbjct: 177 QF-ADIIGMTLVPEVSLAGELALCYSVIASITDYDVW-STKPVDAREVMNIMKQNDHKVR 234
Query: 239 ALITKAIPLIPKERNCPCKDALKGA 263
++ A+PLI KER C C L A
Sbjct: 235 DILFNALPLIKKERKCSCSLRLDNA 259
>gb|AAK42494.1| 5'-methylthioadenosine phosphorylase (mtaP) [Sulfolobus
solfataricus]
Length = 270
Score = 228 bits (574), Expect = 8e-59
Identities = 121/268 (45%), Positives = 171/268 (63%), Gaps = 17/268 (6%)
Query: 4 VAVIGGSGVYDFPA--ENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPPH 59
+ +IGGSG+YD P + + V TPYG+ +TIG + + VAFL RHG+GH IPPH
Sbjct: 10 IGIIGGSGLYD-PGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHGRGHRIPPH 68
Query: 60 KINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEES 119
KINYRANIWAL ELGV +I+ SAVGS+ + + GDFVI DQ ID T +R +F+DG
Sbjct: 69 KINYRANIWALKELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREYSFFDG--- 125
Query: 120 PHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR- 178
VAHV +P+C +R+ I AKEL++ H GTY+C EGPRF T AE + +R
Sbjct: 126 ----PVVAHVSMADPFCNSLRKLAIETAKELNIKTHESGTYICIEGPRFSTRAESRTWRE 181
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELM---NKKSK 235
+ D++GMT PE LA E ++CYAT+A+VT+Y + +T EV +M +K+K
Sbjct: 182 VYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDV-FAEIPVTAEEVTRVMAENTEKAK 240
Query: 236 EIVALITKAIPLIPKERNCPCKDALKGA 263
+++ + + +P P+E +C C ++LK A
Sbjct: 241 KLLYALIQKLPEKPEEGSCSCCNSLKTA 268
>sp|Q60367|Y060_METJA HYPOTHETICAL PROTEIN MJ0060 >gi|2127724|pir||D64307
5'-methylthioadenosine phosphorylase (EC 2.4.2.28) -
Methanococcus jannaschii >gi|1498822|gb|AAB98042.1|
(U67464) methylthioadenosine phosphorylase (mtaP)
[Methanococcus jannaschii]
Length = 252
Score = 224 bits (564), Expect = 1e-57
Identities = 122/260 (46%), Positives = 163/260 (61%), Gaps = 12/260 (4%)
Query: 4 VAVIGGSGVYDFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHKINY 63
+ +IGG+G+ + +K + + T YGK V I N EV L RHG H+IPPHKINY
Sbjct: 2 IGIIGGTGIAEILKGDKEEI-INTKYGKARVIIDKEN--EVVLLFRHGVRHNIPPHKINY 58
Query: 64 RANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPHDR 123
RANI+AL +LGVERI+A ++VGS+ +++PG F + + I+FT R TFYD +
Sbjct: 59 RANIYALKKLGVERILAINSVGSLKEDLKPGMFFVPNDFIEFTKKREETFYDEGK----- 113
Query: 124 KFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILGGD 183
V H+D T+PYCPE+R L + + + Y G YVCTEGPRFET EI Y+ GD
Sbjct: 114 --VVHIDMTDPYCPELRNILKSILDKNNFSY-GEGVYVCTEGPRFETKKEIAIYK-NWGD 169
Query: 184 VVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVALITK 243
VVGMT PE +LARELE+CY ++ +TNYA GIS LT EV+E + + +I+ ++
Sbjct: 170 VVGMTGYPEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVED 229
Query: 244 AIPLIPKERNCPCKDALKGA 263
I ER C CKDALK A
Sbjct: 230 FINYGFGERKCICKDALKHA 249
>pir||E72575 probable 5'-methylthioadenosine phosphorylase APE1885 - Aeropyrum
pernix (strain K1) >gi|5105577|dbj|BAA80890.1|
(AP000062) 275aa long hypothetical
5'-methylthioadenosine phosphorylase [Aeropyrum pernix]
Length = 275
Score = 214 bits (539), Expect = 1e-54
Identities = 121/268 (45%), Positives = 160/268 (59%), Gaps = 16/268 (5%)
Query: 4 VAVIGGSGVYDFP-AENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPPHK 60
V VIGGSG+YD EN V V TPYG + +G V G +VAFL RHG+GH IPPH
Sbjct: 14 VGVIGGSGLYDPGIVENPVEVKVSTPYGNPSDFIVVGDVAGVKVAFLPRHGRGHRIPPHA 73
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPR-TFYDGEES 119
INYRANIWAL LGV+ +I+ SAVGS+ + RPGDFV+ DQ ID T +R TFYDG
Sbjct: 74 INYRANIWALKALGVKWVISVSAVGSLREDYRPGDFVVPDQFIDMTKNRRHYTFYDG--- 130
Query: 120 PHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR- 178
HV +P+C ++R+ LI + + L H RGTYVC EGPRF T AE + ++
Sbjct: 131 ----PVTVHVSMADPFCEDLRQRLIDSGRRLGYTVHERGTYVCIEGPRFSTRAESRVWKD 186
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIV 238
+ D++GMT PE LA E ++CYAT+A+VT+Y + + +T EV +M +
Sbjct: 187 VFKADIIGMTLVPEINLACEAQLCYATLAMVTDYDVW-ADRPVTAEEVERVMISNVERAR 245
Query: 239 ALITKAIPLI---PKERNCPCKDALKGA 263
++ IP + P+ C C AL A
Sbjct: 246 RMLYDVIPKLAGEPELERCSCCRALDTA 273
>emb|CAB90972.1| (AL355832) putative methylthioadenosine phosphorylase [Streptomyces
coelicolor A3(2)]
Length = 280
Score = 209 bits (527), Expect = 2e-53
Identities = 115/265 (43%), Positives = 155/265 (58%), Gaps = 7/265 (2%)
Query: 4 VAVIGGSGVYDFPAENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPPHKI 61
+ VIGGSG Y F ++ V V+TPYG + +G V G VAFL RHG+GH +PPH+I
Sbjct: 9 IGVIGGSGFYSF-LDDVTEVRVDTPYGPPSDSLFLGEVAGRRVAFLPRHGRGHHLPPHRI 67
Query: 62 NYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPH 121
NYRAN+WAL +G +++ AVG + P PG ++ DQ +D T SRP T++DG P
Sbjct: 68 NYRANLWALRSVGARQVLGPCAVGGLRPEYGPGTLLVPDQFVDRTRSRPSTYFDGLPMPD 127
Query: 122 DR-KFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRIL 180
V HV +PYCP R A + AA+ GT V EGPRF T AE +R
Sbjct: 128 GTVPNVVHVSLADPYCPTGRAAALKAARGREWEPVDGGTLVVVEGPRFGTRAESLWHRAQ 187
Query: 181 GGDVVGMTQCPEAILARELEICYATVAIVTNYAAGI-SGKKLTHSEVVELMNKKSKEIVA 239
G VVGMT PEA LARELE+CY ++ +VT+ AG SG+ ++H EV+ + +
Sbjct: 188 GWSVVGMTGHPEAALARELELCYTSLTLVTDLDAGAESGEGVSHEEVLRVFAANVDRLRG 247
Query: 240 LITKAIPLIPK--ERNCPCKDALKG 262
++ A+ +P ER+CPC AL G
Sbjct: 248 VLFDAVAALPASGERDCPCGAALGG 272
>pdb|1CG6|A Chain A, Structure Of Human 5'-Deoxy-5'-Methylthioadenosine
Phosphorylase Complexed With 5'-Deoxy-5'-
Methylthioadenosine And Sulfate At 1.7 A Resolution
>gi|5542154|pdb|1CB0|A Chain A, Structure Of Human
5'-Deoxy-5'-Methylthioadenosine Phosphorylase At 1.7 A
Resolution
Length = 283
Score = 195 bits (490), Expect = 5e-49
Identities = 101/251 (40%), Positives = 152/251 (60%), Gaps = 6/251 (2%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPP 58
V++ +IGG+G+ D E + V+TP+GK + +G + + LARHG+ H+I P
Sbjct: 10 VKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMP 69
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
K+NY+ANIWAL E G +I T+A GS+ ++PGD VI+DQ ID T RP++FYDG
Sbjct: 70 SKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSH 129
Query: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
S + V H+ EP+CP+ R LI AK+L L H +GT V EGPRF + AE +R
Sbjct: 130 S--CARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFR 187
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKK-LTHSEVVELMNKKSKEI 237
G DV+ MT PE +LA+E ICYA++A+ T+Y ++ ++ V++ + + + +
Sbjct: 188 TWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKA 247
Query: 238 VALITKAIPLI 248
+L+ IP I
Sbjct: 248 KSLLLTTIPQI 258
>gi|4505273 5'-methylthioadenosine phosphorylase [Homo sapiens]
>gi|2494053|sp|Q13126|MTAP_HUMAN 5'-METHYLTHIOADENOSINE
PHOSPHORYLASE (MTA PHOSPHORYLASE) (MTAPASE)
>gi|2134671|pir||I38969 5'-methylthioadenosine
phosphorylase (EC 2.4.2.28) - human
>gi|847724|gb|AAA81646.1| (U22233) methylthioadenosine
phosphorylase [Homo sapiens]
Length = 283
Score = 194 bits (489), Expect = 7e-49
Identities = 101/251 (40%), Positives = 152/251 (60%), Gaps = 6/251 (2%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPP 58
V++ +IGG+G+ D E + V+TP+GK + +G + + LARHG+ H+I P
Sbjct: 10 VKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCILLARHGRQHTIMP 69
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
K+NY+ANIWAL E G +I T+A GS+ ++PGD VI+DQ ID T RP++FYDG
Sbjct: 70 SKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSH 129
Query: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
S + V H+ EP+CP+ R LI AK+L L H +GT V EGPRF + AE +R
Sbjct: 130 S--CARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFR 187
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKK-LTHSEVVELMNKKSKEI 237
G DV+ MT PE +LA+E ICYA++A+ T+Y ++ ++ V++ + + + +
Sbjct: 188 TWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKA 247
Query: 238 VALITKAIPLI 248
+L+ IP I
Sbjct: 248 KSLLLTTIPQI 258
>gb|AAG38871.1|L40432_1 (L40432) methylthioadenosine phosphorylase [Homo sapiens]
Length = 283
Score = 194 bits (487), Expect = 1e-48
Identities = 101/251 (40%), Positives = 152/251 (60%), Gaps = 6/251 (2%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPP 58
V++ +IGG+G+ D E + V+TP+GK + +G + + LARHG+ H+I P
Sbjct: 10 VKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMP 69
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
K+NY+ANIWAL E G +I T+A GS+ ++PGD VI+DQ ID T RP++FYDG
Sbjct: 70 SKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSH 129
Query: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
S + V H+ EP+CP+ R LI AK+L L H +GT V EGPRF + AE +R
Sbjct: 130 S--CARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFR 187
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKK-LTHSEVVELMNKKSKEI 237
G DV+ MT PE +LA+E ICYA++A+ T+Y ++ ++ V++ + + + +
Sbjct: 188 TWGADVINMTTVPEVVLAKEAGICYASIAMGTDYDCWKEHEEAVSVDRVLKTLKENANKA 247
Query: 238 VALITKAIPLI 248
+L+ IP I
Sbjct: 248 KSLLLTTIPQI 258
>pir||F83270 probable nucleoside phosphorylase PA3004 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9949105|gb|AAG06392.1|AE004725_5 (AE004725) probable
nucleoside phosphorylase [Pseudomonas aeruginosa]
Length = 245
Score = 189 bits (476), Expect = 2e-47
Identities = 102/243 (41%), Positives = 144/243 (58%), Gaps = 11/243 (4%)
Query: 5 AVIGGSGVYDFPAEN-KRSVTVETPYGKVEVTI--GLVNGEEVAFLARHGKGHSIPPHKI 61
A+IGG+G+ S+ +ETPYG + G G EV FLARHG H PPH++
Sbjct: 5 AIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHPHRFPPHQV 64
Query: 62 NYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPH 121
NYRAN+WAL + G E +IA +AVG ++ M G + Q+ID+T R T++ G
Sbjct: 65 NYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAG----- 119
Query: 122 DRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILG 181
D + V H+DF+ PY +R+ LI A + L L + G Y CT+GPR ET AEI G
Sbjct: 120 DIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDG 179
Query: 182 GDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNK---KSKEIV 238
D+VGMT PEA LAREL++ YA +A+V N AAG S +T +E+ + ++ K +E++
Sbjct: 180 NDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVL 239
Query: 239 ALI 241
A +
Sbjct: 240 ARV 242
>pir||B70546 probable pnp protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2113997|emb|CAB08986.1| (Z95558) pnp [Mycobacterium
tuberculosis]
Length = 264
Score = 180 bits (452), Expect = 2e-44
Identities = 99/254 (38%), Positives = 142/254 (54%), Gaps = 16/254 (6%)
Query: 4 VAVIGGSGVYDFPAENKRSVTVETPYGK--VEVTIGLVNGEEVAFLARHGKGHSIPPHKI 61
+ VIGGSG Y F + R+V +TPYG+ +TIG + +VAFL RHG H H +
Sbjct: 8 LGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGTIGVHDVAFLPRHGAHHQYSAHAV 67
Query: 62 NYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPH 121
YRAN+WAL LGV R+ AVGS++P + PG V+ DQ++D T R T++D
Sbjct: 68 PYRANMWALRALGVRRVFGPCAVGSLDPELEPGAVVVPDQLVDRTSGRADTYFDFGG--- 124
Query: 122 DRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILG 181
H F +PYCP +R A+ + GT V +GPRF T AE + + G
Sbjct: 125 -----VHAAFADPYCPTLRAAVTGLPGVVD-----GGTMVVIQGPRFSTRAESQWFAAAG 174
Query: 182 GDVVGMTQCPEAILARELEICYATVAIVTNYAAGI-SGKKLTHSEVVELMNKKSKEIVAL 240
++V MT PEA+LARELE+CYA +A+VT+ AG+ +G + ++V + + + L
Sbjct: 175 CNLVNMTGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAADVFAAFGENIELLKRL 234
Query: 241 ITKAIPLIPKERNC 254
+ AI + ER C
Sbjct: 235 VRAAIDRVADERTC 248
>gb|AAF57869.1| (AE003803) CG4802 gene product [Drosophila melanogaster]
Length = 289
Score = 180 bits (452), Expect = 2e-44
Identities = 100/276 (36%), Positives = 154/276 (55%), Gaps = 17/276 (6%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKVEVTI--GLVNGEEVAFLARHGKGHSIPP 58
V++ +IGGSG+ D E ++ VETPYG+ + G +NG + LARHG+ H I P
Sbjct: 16 VKIGIIGGSGLDDPDILEQRQERVVETPYGEPSDALIEGEINGVQCVLLARHGRKHDIMP 75
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGE- 117
+NYRANIWAL ++G +I ++A GS+ ++PG+ V+ ID T R +TFYDG+
Sbjct: 76 SNVNYRANIWALRDVGCTHLIVSTACGSLREEIKPGNLVVPHDFIDRTTKRLQTFYDGKA 135
Query: 118 ESPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAY 177
+SP + V H+ + R L+ AAKEL +P H + T V EGPRF + +E +
Sbjct: 136 QSP---RGVCHLPMFPAFSERTRNILLQAAKELEIPAHDKATIVTIEGPRFSSRSESHMF 192
Query: 178 RILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISG-KKLTHSEVVELMNKKSKE 236
R GGD++ MT CPE +LA+E + Y +VAI T+Y G + + +V+ + +
Sbjct: 193 RQWGGDLINMTTCPEVVLAKEAGLLYGSVAIATDYDCWRMGCEGVNVQDVLRTFAENVIK 252
Query: 237 IVALITKAIPLIPKE---------RNCPCKDALKGA 263
+ ++ A+ I KE + C C + + GA
Sbjct: 253 VKKILVNAVGRIAKEDWSEDILNAKQCVCNNTMSGA 288
>pir||H82568 purine nucleoside phosphorylase XF2353 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107527|gb|AAF85152.1|AE004045_10 (AE004045) purine
nucleoside phosphorylase [Xylella fastidiosa]
Length = 237
Score = 180 bits (451), Expect = 2e-44
Identities = 103/230 (44%), Positives = 142/230 (60%), Gaps = 9/230 (3%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPP 58
+ +AVIGG+GVY ++ + VET YG+ + +G++ G+ VAF ARHG+ H++PP
Sbjct: 4 IALAVIGGTGVYTLSQLDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHALPP 63
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
HKINYRANI AL +LGV R++A + VG +N P V DQ+ID+T R TF +
Sbjct: 64 HKINYRANIAALQQLGVSRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCEEVG 123
Query: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
S V HVDF PY P +R L+ AA+++ + G Y T+GPR ET AEI R
Sbjct: 124 SE-----VLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCYGVTQGPRLETIAEIARLR 178
Query: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGI-SGKKLTHSEVV 227
G D+VGMT PEA LARE + YA + IV+N+AAG G ++T E++
Sbjct: 179 RDGCDLVGMTGMPEAALAREKGLEYACLGIVSNWAAGCGDGAEITMGEIL 228
>pir||S76441 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1653658|dbj|BAA18570.1| (D90915) hypothetical
protein [Synechocystis sp.]
Length = 326
Score = 177 bits (445), Expect = 1e-43
Identities = 101/215 (46%), Positives = 132/215 (60%), Gaps = 13/215 (6%)
Query: 4 VAVIGGSGVYDFPA-ENKRSVTVETPYGKVEVT--IGLVNGEEVAFLARHGKGHSIPPHK 60
+ +IGGSG+Y A +N VT++TP+G + +G + G VAFLARHG+GH + P +
Sbjct: 38 IGIIGGSGLYQMEALKNVEEVTLDTPFGAPSDSFIVGELAGVRVAFLARHGRGHHLLPSE 97
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESP 120
I +RANI + +LGV+ +I+ SAVGS+ +P D V+ DQ ID T R TF+ GE
Sbjct: 98 IPFRANIHGMKQLGVKYLISASAVGSLQAEAKPLDMVVPDQFIDRTRQRISTFF-GE--- 153
Query: 121 HDRKFVAHVDFTEPYCPEIRRALIAAAKELSL---PYHPRGTYVCTEGPRFETAAEIKAY 177
VAH+ F P CP++ + L A L L H RGTYV EGP F T AE Y
Sbjct: 154 ---GIVAHIGFGNPICPQLAQCLSTAIAGLELEGVTLHDRGTYVSMEGPAFSTIAESNLY 210
Query: 178 RILGGDVVGMTQCPEAILARELEICYATVAIVTNY 212
R GG V+GMT PEA LARE EI YAT+A+VT+Y
Sbjct: 211 RSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDY 245
>sp|Q09438|MTAP_CAEEL PUTATIVE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE (MTA PHOSPHORYLASE)
>gi|7494774|pir||T29047 hypothetical protein B0228.7 -
Caenorhabditis elegans >gi|726367|gb|AAC38810.1|
(U23168) similar to hypothetical 25.8 kd protein in PETC
3' region in R. rubrum (SP:YPE2_RHORU, P23139)
[Caenorhabditis elegans]
Length = 285
Score = 174 bits (436), Expect = 1e-42
Identities = 102/253 (40%), Positives = 143/253 (56%), Gaps = 8/253 (3%)
Query: 1 MVRVAVIGGSGVYDFPAE-NKRSVTVETPYGKV--EVTIGLVNGEEVAFLARHGKGHSIP 57
MV+V +IGGSG+ D + +V V+TPYGK +V G +NG E LARHG+ H I
Sbjct: 1 MVKVGIIGGSGLEDPNILLDPVTVAVDTPYGKPSDDVVEGTINGVECVLLARHGRKHDIM 60
Query: 58 PHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGE 117
P +N+RAN+WALY GV+ IIA++A GS+ N+ PG + D + T R TF+DG
Sbjct: 61 PGNVNFRANLWALYSRGVDVIIASTACGSLQENVEPGHLLFPDSV---TTGRQSTFFDG- 116
Query: 118 ESPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAY 177
S V H+ Y ++R+ LI+ A+ L +H G VC EGPRF T AE +
Sbjct: 117 -SYDQAPGVCHIQAHPTYNEKLRQVLISTAERCQLVHHRTGFGVCIEGPRFSTKAESMVF 175
Query: 178 RILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEI 237
+ G +V MT PE ILA+EL I YAT A+VT+Y +T S V+++ ++
Sbjct: 176 KSWGASLVNMTMMPECILAKELGIPYATTALVTDYDCWKEEDHVTASSVMKVFAANVEKA 235
Query: 238 VALITKAIPLIPK 250
L +A+ I K
Sbjct: 236 KTLFVEAVGEIGK 248
>emb|CAB75631.1| (AL157415) 5'-methylthioadenosine phosphorylase [Leishmania major]
Length = 306
Score = 153 bits (384), Expect = 1e-36
Identities = 97/241 (40%), Positives = 133/241 (54%), Gaps = 19/241 (7%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKV--EVTIGLVNGEEVAFLARHGKGHSIPP 58
V +AVIGGSGVY ++ V TPYG ++ + V+G FL RHG H P
Sbjct: 10 VAIAVIGGSGVYKLNCLQDAVYHDVPTPYGNPSGQLCVAKVDGVPCVFLPRHGPHHQYNP 69
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
+INYRANI AL ++GV I+A +AVGS++ + +PGD V+ DQIID T R TF++
Sbjct: 70 SEINYRANICALKQMGVRYILAINAVGSLDESYKPGDLVLCDQIIDKTYMRKATFFED-- 127
Query: 119 SPHDRKFVAHVDFTEP----YCPEIRRALI-----AAAKELSLPYHPRGTYVCTEGPRFE 169
V H DF P + + AL+ AA + + H GT V EGP+F
Sbjct: 128 -----GVVVHADFAHPTSRIFNSIVHEALLRCFPDVAAGKGTFQIHSSGTLVTMEGPQFS 182
Query: 170 TAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVEL 229
T AE + +GG ++GMT EA LARE EI YATVA+VT+ A + ++V ++
Sbjct: 183 TKAESLLNKQMGGHLIGMTSATEARLAREAEIAYATVAMVTDMDAWSDAPHVDAAQVTKV 242
Query: 230 M 230
M
Sbjct: 243 M 243
>gi|11499377 methylthioadenosine phosphorylase (mtaP) [Archaeoglobus fulgidus]
>gi|7450061|pir||C69473 methylthioadenosine
phosphorylase (mtaP) homolog - Archaeoglobus fulgidus
>gi|2648757|gb|AAB89459.1| (AE000979)
methylthioadenosine phosphorylase (mtaP) [Archaeoglobus
fulgidus]
Length = 243
Score = 139 bits (347), Expect = 3e-32
Identities = 83/251 (33%), Positives = 134/251 (53%), Gaps = 15/251 (5%)
Query: 4 VAVIGGSGVYDFPA-ENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHKIN 62
+ +IGG+ + + ++ +ETPYG E+ +G V+G +VA + RHGK PPH+IN
Sbjct: 2 IGIIGGTHILEIKVLKDVEETRIETPYGTAEIDVGRVDGIDVAIIQRHGKRKDKPPHRIN 61
Query: 63 YRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPHD 122
+ AN +AL LGV+ +I +VG++ +I ID F+ G +D
Sbjct: 62 HAANFYALKSLGVKYVIGMGSVGALREEYSLPSLIIPHDYID--------FFSGVTIYND 113
Query: 123 RKFVAHVDFTEPYCPEIRRALIAAAKEL-SLPYHPRGTYVCTEGPRFETAAEIKAYRILG 181
+ HV T + +R L+ A+++ S P +G Y T GPR ET AEI +
Sbjct: 114 S--LVHV--TPGFDEYLREVLVEVARKISSFPVIDKGVYFQTRGPRLETKAEIAMIKSF- 168
Query: 182 GDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVALI 241
D VGMT EA +AREL + YA V + NYA GI + + + E+VE + ++E + ++
Sbjct: 169 ADCVGMTAGSEATIARELGLSYAIVCTMDNYAHGIKNQSIDYREIVEKAKENARECLKIV 228
Query: 242 TKAIPLIPKER 252
+A+ + +E+
Sbjct: 229 EEAVKKVWEEK 239
>sp|Q09816|YAC2_SCHPO HYPOTHETICAL 33.9 KD PROTEIN C16C9.02C IN CHROMOSOME I
>gi|2130279|pir||S62472 probable Methylthioadenosine
phosphorylase - fission yeast (Schizosaccharomyces
pombe) >gi|1019814|emb|CAA91190.1| (Z54366) putative
Methylthioadenosine phosphorylase [Schizosaccharomyces
pombe]
Length = 307
Score = 138 bits (344), Expect = 7e-32
Identities = 91/223 (40%), Positives = 121/223 (53%), Gaps = 19/223 (8%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKVEVTIGLV---NGEEVAFLARHGKGHSIP 57
+ + VIGGSG YD P + SV TP+G I + +G +AFLARHG GH
Sbjct: 8 ILLGVIGGSGFYDLPGFDIVESVNPITPWGYPASPISIARTTSGFLIAFLARHGVGHIYT 67
Query: 58 PHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTV-SRPRTFYDG 116
P ++ RANI AL LGV I++ SAVGS+ ++ P DFV+ QIID T+ +RP TF++
Sbjct: 68 PTEVPSRANIAALKSLGVLAIVSFSAVGSLREDIPPEDFVLPTQIIDRTLCARPNTFFES 127
Query: 117 EESPHDRKFVAHVDFTEPYCPEIRRALIAAAKEL----SLPYHPRG---TYVCTEGPRFE 169
VAHV F +P+ ++ L + L L +G T VC EGP F
Sbjct: 128 -------GCVAHVSFGDPFDQDLYEILSSCGSNLKNGSKLHTKRKGDDLTVVCMEGPAFS 180
Query: 170 TAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNY 212
T AE YR G ++ M+ PEA LARE EI Y V + T+Y
Sbjct: 181 TRAESNLYRSWGASIINMSVIPEAKLAREAEIAYQMVCMATDY 223
>emb|CAA62156.1| (X90564) orf [Saccharomyces cerevisiae]
Length = 337
Score = 136 bits (340), Expect = 2e-31
Identities = 91/268 (33%), Positives = 136/268 (49%), Gaps = 23/268 (8%)
Query: 2 VRVAVIGGSGVYDFPAENKRSVT--VETPYGKVE--VTIGLVNGEE----VAFLARHGKG 53
V + +IGG+G+Y+ ++ + TP+G VTI G VAF+ARHG
Sbjct: 33 VDLGIIGGTGLYNLDCLEPIALVPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGIN 92
Query: 54 HSIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTF 113
H PP K+ +RAN+ AL L + +++ SAVGS+ P+++P DFV+ QIID T +
Sbjct: 93 HEYPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSS 152
Query: 114 YDGEESPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLP---------YHPRGTYVCTE 164
Y +E V HV F +P+ + + E++ P Y T VC E
Sbjct: 153 YFNDEG-----LVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCME 207
Query: 165 GPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA-GISGKKLTH 223
GP+F T AE K YR+ GG V+ M+ PEA LARE E+ Y + + T+Y A + +T
Sbjct: 208 GPQFSTRAESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTV 267
Query: 224 SEVVELMNKKSKEIVALITKAIPLIPKE 251
V+ + + L +K I + KE
Sbjct: 268 ETVIGNLTNNGRNANILASKIIVSMAKE 295
>gi|6323045 regulator of ADH2 expression; Meu1p [Saccharomyces cerevisiae]
>gi|2494054|sp|Q07938|YL17_YEAST HYPOTHETICAL 37.9 KD
PROTEIN IN PPR1-SNF7 INTERGENIC REGION
>gi|2131750|pir||S64839 hypothetical protein YLR017w -
yeast (Saccharomyces cerevisiae)
>gi|1360318|emb|CAA97539.1| (Z73189) ORF YLR017w
[Saccharomyces cerevisiae]
Length = 337
Score = 136 bits (339), Expect = 3e-31
Identities = 91/268 (33%), Positives = 136/268 (49%), Gaps = 23/268 (8%)
Query: 2 VRVAVIGGSGVYDFPAENKRSVT--VETPYGKVE--VTIGLVNGEE----VAFLARHGKG 53
V + +IGG+G+Y+ ++ + TP+G VTI G VAF+ARHG
Sbjct: 33 VDLGIIGGTGLYNLDCLEPIALLPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGIN 92
Query: 54 HSIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTF 113
H PP K+ +RAN+ AL L + +++ SAVGS+ P+++P DFV+ QIID T +
Sbjct: 93 HEYPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSS 152
Query: 114 YDGEESPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLP---------YHPRGTYVCTE 164
Y +E V HV F +P+ + + E++ P Y T VC E
Sbjct: 153 YFNDEG-----LVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCME 207
Query: 165 GPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA-GISGKKLTH 223
GP+F T AE K YR+ GG V+ M+ PEA LARE E+ Y + + T+Y A + +T
Sbjct: 208 GPQFSTRAESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTV 267
Query: 224 SEVVELMNKKSKEIVALITKAIPLIPKE 251
V+ + + L +K I + KE
Sbjct: 268 ETVIGNLTNNGRNANILASKIIVSMAKE 295
>emb|CAB61871.1| (AL133252) putative phosphorylase [Streptomyces coelicolor A3(2)]
Length = 262
Score = 134 bits (334), Expect = 1e-30
Identities = 82/251 (32%), Positives = 126/251 (49%), Gaps = 11/251 (4%)
Query: 2 VRVAVIGGSGVYDFP-AENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHK 60
+R+ VI GSG YD+P E TV T +G V VT G + G E+ L+RHG GH +
Sbjct: 1 MRIGVITGSGSYDWPHLEGAAERTVVTEHGAVTVTEGRLGGAEIVQLSRHGTGHHRLSSQ 60
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSR-----PRTFYD 115
++++AN+ AL + E +++ + GS+ P++RPG V+ D + F +R P T+YD
Sbjct: 61 VDHKANLAALLAVEAEAVVSFTVCGSLEPDVRPGSLVVFDDLY-FPANRLPDGTPCTWYD 119
Query: 116 GEESPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIK 175
H F P+ +R+ALI AA + +P +G Y +GPRF T E+
Sbjct: 120 TPGGAGR----GHWIFDRPFSEPLRQALITAADQTGVPVATQGVYGHVDGPRFNTRPEVA 175
Query: 176 AYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSK 235
A G + T PE +LA E E+ V VT+YA G++ + +++ M
Sbjct: 176 ALAAAGVSAISQTAGPEVVLAGEAELPMVLVGFVTDYANGVAPEPEPVQALLDRMAASKD 235
Query: 236 EIVALITKAIP 246
L A+P
Sbjct: 236 VFAKLAEHALP 246
>sp|P23139|YPE2_RHORU HYPOTHETICAL 25.8 KD PROTEIN IN PETC 3'REGION >gi|79576|pir||S12259
hypothetical protein 2 (petC 3' region) - Rhodospirillum
rubrum >gi|46387|emb|CAA39061.1| (X55387) ORF2
[Rhodospirillum rubrum]
Length = 238
Score = 108 bits (267), Expect = 8e-23
Identities = 57/114 (50%), Positives = 77/114 (67%), Gaps = 3/114 (2%)
Query: 4 VAVIGGSGVYDFPA-ENKRSVTVETPYGKV--EVTIGLVNGEEVAFLARHGKGHSIPPHK 60
+ VIGGSGVYD E R TVE+P+G V ++ G ++G E+AFL RHG+GH + P
Sbjct: 10 LGVIGGSGVYDIDGLEGARWQTVESPFGDVSDQILRGTLDGLEMAFLPRHGRGHVLAPSD 69
Query: 61 INYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFY 114
+NYRANI AL GV I++ SAVGS+ ++ PG FVI DQ ID T +R ++F+
Sbjct: 70 VNYRANIDALKRAGVTEILSVSAVGSLAEDLPPGTFVIADQFIDRTFAREKSFF 123
>sp|P77834|PUNA_BACST PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (PU-NPASE I) (INOSINE
PHOSPHORYLASE) >gi|2126870|pir||JT0873 purine-nucleoside
phosphorylase (EC 2.4.2.1) - Bacillus stearothermophilus
>gi|1638804|dbj|BAA13509.1| (D87959) purine nucleoside
phosphorylase [Bacillus stearothermophilus]
Length = 274
Score = 104 bits (256), Expect = 1e-21
Identities = 72/238 (30%), Positives = 117/238 (48%), Gaps = 19/238 (7%)
Query: 10 SGVYDFPAENKRSVTVETPYGKVE-VTIGLVNGEEVAFLARHGKGHSIPPHKINYRANIW 68
S + +FP + YG++E T+ ++ G + +G+S K+ + +
Sbjct: 47 SDIPNFPVSTVEGHAGQLVYGQLEGATVVVMQGR-----FHYYEGYSFD--KVTFPVRV- 98
Query: 69 ALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPHDRKF-VA 127
+ LGVE++I T+A G +N + PGD +I+ I+ P P+D V
Sbjct: 99 -MKALGVEQLIVTNAAGGVNESFEPGDLMIISDHINNMGGNPLI------GPNDSALGVR 151
Query: 128 HVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILGGDVVGM 187
D +E Y +R+ A ++ L G YV GP +ET AEI+ R++GGD VGM
Sbjct: 152 FPDMSEAYSKRLRQLAKDVANDIGLRVR-EGVYVANTGPAYETPAEIRMIRVMGGDAVGM 210
Query: 188 TQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVALITKAI 245
+ PE I+AR + ++ ++N AAGI + LTH EV+E K + + + KAI
Sbjct: 211 STVPEVIVARHAGMEVLGISCISNMAAGILDQPLTHDEVIETTEKVKADFLRFV-KAI 267
>sp|P46354|PUNA_BACSU PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (PU-NPASE I) (INOSINE
PHOSPHORYLASE) >gi|7433916|pir||D69680 purine-nucleoside
phosphorylase (EC 2.4.2.1) pnp - Bacillus subtilis
>gi|944944|gb|AAA74434.1| (U32685) purine nucleoside
phosphorylase [Bacillus subtilis]
>gi|1303996|dbj|BAA12651.1| (D84432) YqkO [Bacillus
subtilis] >gi|2634784|emb|CAB14281.1| (Z99116) purine
nucleoside phosphorylase [Bacillus subtilis]
Length = 271
Score = 100 bits (247), Expect = 2e-20
Identities = 78/256 (30%), Positives = 125/256 (48%), Gaps = 23/256 (8%)
Query: 3 RVAVIGGSGV------YDFPAENKRSVTVETPYGKVEVTIG-LVNG--EEVAFLARHGKG 53
++ +I GSG+ + P + K E P VE G LV G E V+ +A G+
Sbjct: 21 KIGLILGSGLGILADEIENPVKLKYEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRF 80
Query: 54 HSIPPH---KINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRP 110
H + K+ + + + LGVE +I T+A G +N R GD +I+ I+F + P
Sbjct: 81 HFYEGYSMEKVTFPVRV--MKALGVEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNP 138
Query: 111 RTFYDGEESPHDRKFVAHV-DFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFE 169
P++ F A D + Y ++ AK+L++P +G Y GP +E
Sbjct: 139 LI------GPNEADFGARFPDMSSAYDKDLSSLAEKIAKDLNIPIQ-KGVYTAVTGPSYE 191
Query: 170 TAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVEL 229
T AE++ R +G D VGM+ PE I+A + ++ ++N AAGI + L+H EV+E+
Sbjct: 192 TPAEVRFLRTMGSDAVGMSTVPEVIVANHAGMRVLGISCISNAAAGILDQPLSHDEVMEV 251
Query: 230 MNKKSKEIVALITKAI 245
K + L+ KAI
Sbjct: 252 TEKVKAGFLKLV-KAI 266
>dbj|BAB05250.1| (AP001512) purine nucleoside phosphorylase [Bacillus halodurans]
Length = 272
Score = 99.8 bits (245), Expect = 3e-20
Identities = 76/257 (29%), Positives = 123/257 (47%), Gaps = 27/257 (10%)
Query: 4 VAVIGGSGVYDFPAENKRSVTVETPYGKV-------------EVTIGLVNGEEVAFLARH 50
+ +I GSG+ E ++ V V PY + ++ IG++ G++V +A
Sbjct: 24 IGLILGSGLGILADEIEQPVKV--PYSDIPHFPVSTVQGHAGQLVIGMLEGKQV--IAMQ 79
Query: 51 GKGHSIPPHKINYRA-NIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSR 109
G+ H + + + + LGVE+II T+A G +N + GD +I+ I+
Sbjct: 80 GRFHFYEGYSLEVVTFPVRVMKALGVEQIIVTNAAGGVNESFEAGDLMIIRDHINNMAQN 139
Query: 110 PRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRF 168
P P+D F V D + Y +R L+L G YV GP +
Sbjct: 140 PLI------GPNDEAFGVRFPDMSNAYSERLRTLAKEKGNTLNLKLQ-EGVYVANTGPVY 192
Query: 169 ETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVE 228
ET AE++ R LGGD VGM+ PE I+AR + ++ ++N AAGI + L+H EV+E
Sbjct: 193 ETPAEVRMIRKLGGDAVGMSTVPEVIVARHAGLEVLGISCISNMAAGILPQPLSHDEVIE 252
Query: 229 LMNKKSKEIVALITKAI 245
+ ++ + L+ KAI
Sbjct: 253 TTERVRQDFLNLV-KAI 268
>dbj|BAB05251.1| (AP001512) purine nucleoside phosphorylase [Bacillus halodurans]
Length = 275
Score = 98.3 bits (241), Expect = 9e-20
Identities = 72/257 (28%), Positives = 122/257 (47%), Gaps = 26/257 (10%)
Query: 4 VAVIGGSGVYDFPAENKRSVTVETPYGKV-------------EVTIGLVNGEEVAFLARH 50
+ +I GSG+ + E + +V + PY ++ ++ IG ++G+ V +A
Sbjct: 25 IGLILGSGLGELANEIEEAVHI--PYEQIPNFPVSTVEGHAGQLVIGTLHGKNV--VAMQ 80
Query: 51 GKGHSIPPHKIN-YRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSR 109
G+ H + + + + E+GVE I+ T+A G MN N PGD +I+ ++ T
Sbjct: 81 GRFHYYEGYTMQEVTFPVRVMKEIGVELIVVTNACGGMNKNFAPGDLMIITDHLNMTGDN 140
Query: 110 PRTFYDGEE-SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRF 168
P + EE P D + Y PE+ + A L + +G Y GP +
Sbjct: 141 PLIGPNVEEWGPR------FPDMSHAYTPELVEFVEETANRLDIKVQ-KGVYAGITGPTY 193
Query: 169 ETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVE 228
T AE+ R LGGDV+GM+ PE I+AR + ++ +T+ A G +TH EVV
Sbjct: 194 MTGAELIMLRNLGGDVIGMSTVPEVIVARHAGMKVIGISCITDMAIGEEIAGITHEEVVA 253
Query: 229 LMNKKSKEIVALITKAI 245
+ NK + + L+ + +
Sbjct: 254 VANKTKPKFIKLVKEIV 270
>sp|P45563|XAPA_ECOLI XANTHOSINE PHOSPHORYLASE >gi|7433918|pir||F65014 xanthosine
phosphorylase (EC 2.4.2.-) - Escherichia coli (strain
K-12) >gi|1788746|gb|AAC75460.1| (AE000328) xanthosine
phosphorylase [Escherichia coli K12]
>gi|1799817|dbj|BAA16275.1| (D90869) XANTHOSINE
PHOSPHORYLASE (EC 2.4.2.-). [Escherichia coli]
>gi|1799821|dbj|BAA16278.1| (D90870) XANTHOSINE
PHOSPHORYLASE (EC 2.4.2.-). [Escherichia coli]
Length = 277
Score = 96.3 bits (236), Expect = 3e-19
Identities = 76/251 (30%), Positives = 112/251 (44%), Gaps = 20/251 (7%)
Query: 3 RVAVIGGSGVYDFPAENKRSVT----------VETPYGKV-EVTIGLVNGEEVAFLARHG 51
RVA I GSG+ + + +V V T +G E+ +G + G V + G
Sbjct: 27 RVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQG--VPVVCMKG 84
Query: 52 KGHSIPPHKINYRANIWALYEL-GVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRP 110
+GH + + ++L G E + T+A GS+ P + G V L I+ P
Sbjct: 85 RGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTP 144
Query: 111 RTFYDGEESPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFET 170
+ DR Y E R L AKE P G +V GP FET
Sbjct: 145 MVGLND-----DRFGERFFSLANAYDAEYRALLQKVAKEEGFPL-TEGVFVSYPGPNFET 198
Query: 171 AAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELM 230
AAEI+ +I+GGDVVGM+ PE I AR ++ V+ +TN A G+S KL+H++ +
Sbjct: 199 AAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAA 258
Query: 231 NKKSKEIVALI 241
+ + LI
Sbjct: 259 ELSKQNFINLI 269
>gb|AAD19641.1| (AF109294) hypothetical methylthioadenosine phosphorylase fusion
protein [Homo sapiens]
Length = 143
Score = 95.6 bits (234), Expect = 6e-19
Identities = 47/109 (43%), Positives = 70/109 (64%), Gaps = 3/109 (2%)
Query: 2 VRVAVIGGSGVYDFPA-ENKRSVTVETPYGKVE--VTIGLVNGEEVAFLARHGKGHSIPP 58
V++ +IGG+G+ D E + V+TP+GK + +G + + LARHG+ H+I P
Sbjct: 10 VKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCILLARHGRQHTIMP 69
Query: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTV 107
K+NY+ANIWAL E G +I T+A GS+ ++PGD VI+DQ ID T+
Sbjct: 70 SKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTI 118
>pir||H72217 purine nucleoside phosphorylase - Thermotoga maritima (strain
MSB8) >gi|4982314|gb|AAD36802.1|AE001812_12 (AE001812)
purine nucleoside phosphorylase [Thermotoga maritima]
Length = 299
Score = 95.6 bits (234), Expect = 6e-19
Identities = 75/260 (28%), Positives = 126/260 (47%), Gaps = 29/260 (11%)
Query: 4 VAVIGGSGVYDFPAE-NKRSVTVETPYGKV-------------EVTIGLVNGEEVAFLA- 48
+A+I GSG+ E K + + PY ++ E+ G + G+ V +
Sbjct: 48 IAIILGSGLSVIADEVEKEGTSKKIPYSEIPGFPISTAPGHKGELIFGKLFGKNVMLMNG 107
Query: 49 --RHGKGHSIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFT 106
+ +G+S+ ++ + + L LGVE +I T+A G +NP+ G +I+ I+F
Sbjct: 108 RFHYYEGYSMK--EVTFPIRVMQL--LGVEILIVTNAAGGLNPDFEVGRPMIITDHINFM 163
Query: 107 VSRPRTFYDGEE-SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEG 165
P + +E P D +EPY E+ +A+EL +P + +G YV G
Sbjct: 164 GDNPLIGPNVDEWGPR------FPDMSEPYDKELIELAYNSARELGIPVY-QGVYVAVTG 216
Query: 166 PRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSE 225
P FET AE++ R G D VGM+ PE I+AR +I ++ +T+ A K LT E
Sbjct: 217 PCFETPAELRMLRKFGADAVGMSTVPEVIVARHGQIRVLGISAITDRAVPEDLKPLTAEE 276
Query: 226 VVELMNKKSKEIVALITKAI 245
V+E+ K ++I +I + +
Sbjct: 277 VLEVAEKTGRKIAQIIFEVV 296
>pir||H72233 purine nucleoside phosphorylase - Thermotoga maritima (strain
MSB8) >gi|4982167|gb|AAD36663.1|AE001804_7 (AE001804)
purine nucleoside phosphorylase [Thermotoga maritima]
Length = 265
Score = 94.8 bits (232), Expect = 1e-18
Identities = 68/224 (30%), Positives = 108/224 (47%), Gaps = 18/224 (8%)
Query: 24 TVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHK-INYRANIWALYELGVERIIATS 82
TVE GK+ G ++ + V +A G+ H H ++ +GV+ ++ T+
Sbjct: 55 TVEGHSGKL--VFGRISDKPVMIMA--GRFHLYEGHDPATVAFPVYLAKYVGVKGVVVTN 110
Query: 83 AVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPHDRKFVAHV-DFTEPYCPEIRR 141
A G++NP +PG+ +++ II+F P P+D K D + PE R
Sbjct: 111 AAGAINPEFKPGEIILVRDIINFMFRNPL------RGPNDEKIGPRFPDMSSVVDPEWAR 164
Query: 142 ALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEI 201
+ + LSL G Y+ GP +ET AEI+ + LG D+VGM+ PE I A+ +
Sbjct: 165 KI---QERLSLK---EGVYIGVLGPSYETPAEIRVFEKLGADLVGMSTVPEVIAAKHCGL 218
Query: 202 CYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVALITKAI 245
+ VTN AAGI+ +L+H EVV +I +T A+
Sbjct: 219 KVVVFSCVTNMAAGITHGRLSHEEVVRTTKMAQGKIEKALTTAV 262
>pdb|1QE5|A Chain A, Purine Nucleoside Phosphorylase From Cellulomonas Sp. In
Complex With Phosphate >gi|6730448|pdb|1QE5|B Chain B,
Purine Nucleoside Phosphorylase From Cellulomonas Sp. In
Complex With Phosphate >gi|6730449|pdb|1QE5|C Chain C,
Purine Nucleoside Phosphorylase From Cellulomonas Sp. In
Complex With Phosphate >gi|6730134|pdb|1C3X|A Chain A,
Purine Nucleoside Phosphorylase From Cellulomonas Sp. In
Complex With 8-Iodo-Guanine >gi|6730135|pdb|1C3X|B Chain
B, Purine Nucleoside Phosphorylase From Cellulomonas Sp.
In Complex With 8-Iodo-Guanine >gi|6730136|pdb|1C3X|C
Chain C, Purine Nucleoside Phosphorylase From
Cellulomonas Sp. In Complex With 8-Iodo-Guanine
Length = 266
Score = 86.2 bits (210), Expect = 4e-16
Identities = 71/221 (32%), Positives = 95/221 (42%), Gaps = 27/221 (12%)
Query: 21 RSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHKINYRANIWALYELGVERIIA 80
RS+ VE G V + L + + GKG H + A G E +I
Sbjct: 67 RSIRVERADGSVRHALVLGSRTHLY----EGKGVRAVVHGVRTAA------ATGAETLIL 116
Query: 81 TSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPHDRKFVAHVDFTEPYCPEIR 140
T+ G +N G V+L I+ T P E P VD T+ Y P +R
Sbjct: 117 TNGCGGLNQEWGAGTPVLLSDHINLTARSPL------EGP------TFVDLTDVYSPRLR 164
Query: 141 RALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELE 200
L P G Y GP +ET AE++ ILG D+VGM+ EAI AR
Sbjct: 165 ELAHRVDPTL-----PEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCG 219
Query: 201 ICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVALI 241
+ V++VTN AAGIS L+H+EV+E I AL+
Sbjct: 220 LEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALL 260
>pdb|1PBN| Purine Nucleoside Phosphorylase >gi|4699623|pdb|4PNP| The High
Resolution Crystal Structure Of Bovine Spleen Purine
Nucleoside Phosphorylase In Complex Forms With Phosphate
And 9-Deazainosine >gi|4699622|pdb|3PNP| The High
Resolution Crystal Structure Of Bovine Spleen Purine
Nucleoside Phosphorylase In Complex Forms With Phosphate
And 9-Deazainosine
Length = 289
Score = 84.3 bits (205), Expect = 1e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVS 108
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPG- 140
Query: 109 RPRTFYDGEE---SPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ GE P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 141 -----FSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 284
>pdb|1A9T| Bovine Purine Nucleoside Phosphorylase Complexed With
9-Deazainosine And Phosphate
Length = 284
Score = 84.3 bits (205), Expect = 1e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVS 108
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPG- 140
Query: 109 RPRTFYDGEE---SPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ GE P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 141 -----FSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 284
>pdb|1A9P| Bovine Purine Nucleoside Phosphorylase Complexed With
9-Deazainosine And Phosphate >gi|3402089|pdb|1A9O|
Bovine Purine Nucleoside Phosphorylase Complexed With
Phosphate >gi|3402093|pdb|1A9S| Bovine Purine
Nucleoside Phosphorylase Complexed With Inosine And
Sulfate
Length = 289
Score = 84.3 bits (205), Expect = 1e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVS 108
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPG- 140
Query: 109 RPRTFYDGEE---SPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ GE P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 141 -----FSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 284
>pir||S66203 purine-nucleoside phosphorylase (EC 2.4.2.1) - bovine
>gi|1042206|gb|AAB34886.1| purine nucleoside
phosphorylase, PNP, purine nucleoside:orthophosphate
ribosyltransferase {EC 2.4.2.1} [cattle, spleen,
Peptide, 284 aa] >gi|1580938|prf||2116271A purine
nucleoside phosphorylase [Bos taurus]
Length = 284
Score = 83.9 bits (204), Expect = 2e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVS 108
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPG- 140
Query: 109 RPRTFYDGEE---SPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ GE P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 141 -----FSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 284
>sp|P55859|PNPH_BOVIN PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
Length = 289
Score = 83.9 bits (204), Expect = 2e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVS 108
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPG- 140
Query: 109 RPRTFYDGEE---SPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ GE P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 141 -----FSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 284
>pdb|1B8O|A Chain A, Purine Nucleoside Phosphorylase >gi|4558113|pdb|1B8N|A
Chain A, Purine Nucleoside Phosphorylase
Length = 284
Score = 83.9 bits (204), Expect = 2e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVS 108
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPG- 140
Query: 109 RPRTFYDGEE---SPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ GE P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 141 -----FSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 284
>pdb|1FXU|A Chain A, Purine Nucleoside Phosphorylase From Calf Spleen In
Complex With N(7)-Acycloguanosine Inhibitor And A
Phosphate Ion
Length = 289
Score = 83.9 bits (204), Expect = 2e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID---F 105
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+ F
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGF 141
Query: 106 TVSRPRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ P P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 142 SGQNPL------RGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 284
>gi|7305395 purine-nucleoside phopshorylase [Mus musculus]
>gi|53750|emb|CAA39888.1| (X56548) purine-nucleoside
phosphorylase [Mus musculus] >gi|1144567|gb|AAB60510.1|
(U35374) purine nucleoside phosphorylase [Mus musculus]
Length = 289
Score = 83.5 bits (203), Expect = 2e-15
Identities = 74/269 (27%), Positives = 127/269 (46%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVET------PYGKVE-----VTIGLVNGEEVAFLARHG 51
+VAVI GSG+ A K + + P V+ + GL+NG + G
Sbjct: 26 QVAVICGSGLGGLTAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMM--QG 83
Query: 52 KGHSIPPH---KINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID---F 105
+ H + K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+ F
Sbjct: 84 RFHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGF 141
Query: 106 TVSRPRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
P P+D +F V ++ Y ++R+ +A K++ GTYV
Sbjct: 142 CGQNPL------RGPNDERFGVRFPAMSDAYDRDMRQKAFSAWKQMGEQRKLQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + ++LG D VGM+ PE I+AR + +++TN + +K
Sbjct: 196 AGPNFETVAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKA 255
Query: 222 THSEVVELMNKKSKEI---VALITKAIPL 247
H EV++ ++ + V+++ ++IPL
Sbjct: 256 NHMEVLDAGKAAAQTLERFVSILMESIPL 284
>gb|AAC37635.1| (L11291) purine nucleoside phosphorylase [Mus musculus]
Length = 289
Score = 83.5 bits (203), Expect = 2e-15
Identities = 74/269 (27%), Positives = 126/269 (46%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVET------PYGKVE-----VTIGLVNGEEVAFLARHG 51
+VAVI GSG+ A K + + P V+ + GL+NG + G
Sbjct: 26 QVAVICGSGLGGLTAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMM--QG 83
Query: 52 KGHSIPPH---KINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID---F 105
+ H + K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+ F
Sbjct: 84 RFHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGF 141
Query: 106 TVSRPRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
P P+D +F V ++ Y ++R+ A K++ GTYV
Sbjct: 142 CGQNPL------RGPNDERFGVRFPAMSDAYDRDMRQKAFTAWKQMGEQRKLQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + ++LG D VGM+ PE I+AR + +++TN + +K
Sbjct: 196 AGPNFETVAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKA 255
Query: 222 THSEVVELMNKKSKEI---VALITKAIPL 247
H EV++ ++ + V+++ ++IPL
Sbjct: 256 NHKEVLDAGKAAAQTLERFVSILMESIPL 284
>pdb|1VFN| Purine Nucleoside Phosphorylase
Length = 281
Score = 83.5 bits (203), Expect = 2e-15
Identities = 75/269 (27%), Positives = 125/269 (45%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 23 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 80
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID---F 105
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+ F
Sbjct: 81 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGF 138
Query: 106 TVSRPRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ P P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 139 SGQNPL------RGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 192
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 193 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKA 252
Query: 222 THSEVVEL---MNKKSKEIVALITKAIPL 247
H EV+E +K ++ V+L+ +IP+
Sbjct: 253 NHEEVLEAGKQAAQKLEQFVSLLMASIPV 281
>sp|P23492|PNPH_MOUSE PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|2117727|pir||I57010 purine-nucleoside phosphorylase
(EC 2.4.2.1) - mouse >gi|200098|gb|AAA39835.1| (M84563)
purine nucleoside phosphorylase [Mus musculus]
>gi|388919|gb|AAC37634.1| (L11290) purine nucleoside
phosphorylase [Mus musculus musculus]
Length = 289
Score = 83.1 bits (202), Expect = 3e-15
Identities = 74/269 (27%), Positives = 126/269 (46%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVET------PYGKVE-----VTIGLVNGEEVAFLARHG 51
+VAVI GSG+ A K + + P V+ + GL+NG + G
Sbjct: 26 QVAVICGSGLGGLTAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMM--QG 83
Query: 52 KGHSIPPH---KINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID---F 105
+ H + K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+ F
Sbjct: 84 RFHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGF 141
Query: 106 TVSRPRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
P P+D +F V ++ Y ++R+ A K++ GTYV
Sbjct: 142 CGQNPL------RGPNDERFGVRFPAMSDAYDRDMRQKAFTAWKQMGEQRKLQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + ++LG D VGM+ PE I+AR + +++TN + +K
Sbjct: 196 AGPNFETVAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKA 255
Query: 222 THSEVVELMNKKSKEI---VALITKAIPL 247
H EV++ ++ + V+++ ++IPL
Sbjct: 256 NHMEVLDAGKAAAQTLERFVSILMESIPL 284
>sp|O53359|PUNA_MYCTU PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|7433917|pir||B70842 probable deoD protein -
Mycobacterium tuberculosis (strain H37RV)
>gi|2894216|emb|CAA17079.1| (AL021841) deoD
[Mycobacterium tuberculosis]
Length = 268
Score = 83.1 bits (202), Expect = 3e-15
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 18/196 (9%)
Query: 51 GKGHSIPPHKINYRAN-IWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSR 109
G+ H+ H + Y + + A G + ++ T+A G + +++ G V++ ++ T
Sbjct: 87 GRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARS 146
Query: 110 PRTFYDGEESPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFE 169
P GE VD T+ Y P +R + +L+ G Y GP +E
Sbjct: 147 P--LVGGE----------FVDLTDAYSPRLRELARQSDPQLA-----EGVYAGLPGPHYE 189
Query: 170 TAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVEL 229
T AEI+ + LG D+VGM+ E I AR V++VTN AAGI+G+ L+H+EV+
Sbjct: 190 TPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAA 249
Query: 230 MNKKSKEIVALITKAI 245
+ + AL+ I
Sbjct: 250 GAASATRMGALLADVI 265
>sp|P46862|PUNA_MYCLE PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|2145968|pir||S73042 purine nucleoside phosphorylase
pnpH - Mycobacterium leprae >gi|467183|gb|AAA17341.1|
(U00022) pnpH; L308_F2_56 [Mycobacterium leprae]
Length = 268
Score = 82.3 bits (200), Expect = 5e-15
Identities = 69/243 (28%), Positives = 105/243 (42%), Gaps = 20/243 (8%)
Query: 4 VAVIGGSGVYDFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHKINY 63
VA +G S AE +T E+ + V LA G+ H H + +
Sbjct: 42 VAALGSSRAVFPQAELPGFITPNAAGHTGELLSVRIGAHRVLVLA--GRIHPYEGHDLRH 99
Query: 64 RAN-IWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPHD 122
+ + G I+ T+A G + +M G V++ ++ T P H
Sbjct: 100 VVHPVRTACAAGARIIVLTNAAGGLRADMAVGQLVLISDHLNLTTRSPLV------GTH- 152
Query: 123 RKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILGG 182
VD T Y +R+ +A+ + +L G Y GP +ET AEI+ R+LG
Sbjct: 153 -----FVDLTNAYTTRLRK--LASDTDPTLT---EGVYAAQPGPHYETPAEIRMLRMLGA 202
Query: 183 DVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIVALIT 242
D+VGM+ E I AR V++VTN AAGI+GK L H+EV+ + I +L+
Sbjct: 203 DLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGKPLNHAEVLAAGTASANRIGSLLA 262
Query: 243 KAI 245
I
Sbjct: 263 DII 265
>pir||I76672 purine-nucleoside phosphorylase (EC 2.4.2.1) - western wild mouse
>gi|388923|gb|AAC37706.1| (L11292) purine nucleoside
phosphorylase [Mus spretus]
Length = 289
Score = 81.5 bits (198), Expect = 9e-15
Identities = 73/269 (27%), Positives = 126/269 (46%), Gaps = 34/269 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVET------PYGKVE-----VTIGLVNGEEVAFLARHG 51
+VAVI GSG+ A K + + P V+ + GL+NG + G
Sbjct: 26 QVAVICGSGLGGLAAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMM--QG 83
Query: 52 KGHSIPPH---KINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID---F 105
+ H + K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+ F
Sbjct: 84 RFHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGF 141
Query: 106 TVSRPRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
P P++ +F V ++ Y ++R+ A K++ GTYV
Sbjct: 142 CGQNPL------RGPNEERFGVRFPAMSDAYDRDMRQKAFTAWKQMGEQRKLQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + ++LG D VGM+ PE I+AR + +++TN + +K
Sbjct: 196 AGPNFETVAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKA 255
Query: 222 THSEVVELMNKKSKEI---VALITKAIPL 247
H EV++ ++ + V+++ ++IPL
Sbjct: 256 NHMEVLDAGKAAAQTLERFVSILMESIPL 284
>pdb|1A9Q| Bovine Purine Nucleoside Phosphorylase Complexed With Inosine
>gi|3402092|pdb|1A9R| Bovine Purine Nucleoside
Phosphorylase Complexed With Hypoxanthine And Sulfate
Length = 282
Score = 81.1 bits (197), Expect = 1e-14
Identities = 74/267 (27%), Positives = 123/267 (45%), Gaps = 34/267 (12%)
Query: 3 RVAVIGGSGVYDFPAENKRSVTVE-----------TPYGKVEVTIGLVNGEEVAFLARHG 51
+VAVI GSG+ + ++ T + P + G++NG A + G
Sbjct: 26 QVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGR--ACVMMQG 83
Query: 52 KGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVS 108
+ H P K+ + ++ L LGVE ++ T+A G +NPN GD +++ I+
Sbjct: 84 RFHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPG- 140
Query: 109 RPRTFYDGEE---SPHDRKF-VAHVDFTEPYCPEIRRALIAAAKELSLPYH-PRGTYVCT 163
+ GE P++ +F V ++ Y ++R+ + K++ GTYV
Sbjct: 141 -----FSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVML 195
Query: 164 EGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKKL 221
GP FET AE + R LG D VGM+ PE I+AR + +++TN S K
Sbjct: 196 GGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKA 255
Query: 222 THSEVVEL---MNKKSKEIVALITKAI 245
H EV+E +K ++ V+L+ +I
Sbjct: 256 NHEEVLEAGKQAAQKLEQFVSLLMASI 282
>emb|CAA52049.1| (X73828) xanthosine phosphorylase [Escherichia coli]
Length = 290
Score = 80.0 bits (194), Expect = 3e-14
Identities = 72/253 (28%), Positives = 112/253 (43%), Gaps = 36/253 (14%)
Query: 3 RVAVIGGSGVYDFPAENKRSVT----------VETPYGKV-EVTIGLVNGEEVAFLARHG 51
RVA I GSG+ + + +V V T +G E+ +G + G V + G
Sbjct: 27 RVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQG--VPVVCMKG 84
Query: 52 KGHSIPPHKINYRANIWALYEL-GVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRP 110
+GH + + ++L G E + T+A GS+ P + G V L I+
Sbjct: 85 RGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHIN------ 138
Query: 111 RTFYDGEESPHDRKFVAHVDFTEP-----YCPEIRRALIAAAK---ELSLPYHPRGTYVC 162
P R +V + E P +R K E P G +V
Sbjct: 139 -------TMPGTRWWVLTMIVLESASSHWQMPTMRNTAHCYKKWPKEEGFPL-TEGVFVS 190
Query: 163 TEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLT 222
GP FETAAEI+ +I+GGDVVGM+ PE I AR ++ V+ +TN A G+S KL+
Sbjct: 191 YPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLS 250
Query: 223 HSEVVELMNKKSK 235
H++ + + +++
Sbjct: 251 HAQTLAAASSQAE 263
>gi|4557801 purine nucleoside phosphorylase [Homo sapiens]
>gi|130377|sp|P00491|PNPH_HUMAN PURINE NUCLEOSIDE
PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|66583|pir||PHHUPN purine-nucleoside phosphorylase
(EC 2.4.2.1) [validated] - human >gi|230388|pdb|1ULB|
Purine Nucleoside Phosphorylase (E.C.2.4.2.1) Complex
With Guanine >gi|230387|pdb|1ULA| Purine Nucleoside
Phosphorylase (E.C.2.4.2.1) >gi|35565|emb|CAA25320.1|
(X00737) PNP [Homo sapiens]
Length = 289
Score = 77.6 bits (188), Expect = 1e-13
Identities = 74/274 (27%), Positives = 126/274 (45%), Gaps = 38/274 (13%)
Query: 3 RVAVIGGSG------------VYDFPA-ENKRSVTVETPYGKVEVTIGLVNGEEVAFLAR 49
+VA+I GSG ++D+ N TV G++ G +NG A +
Sbjct: 26 QVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRL--VFGFLNGR--ACVMM 81
Query: 50 HGKGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID-- 104
G+ H P K+ + ++ L LGV+ ++ T+A G +NP GD +++ I+
Sbjct: 82 QGRFHMYEGYPLWKVTFPVRVFHL--LGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLP 139
Query: 105 -FTVSRPRTFYDGEESPHDRKFVAHVD-FTEPYCPEIRRALIAAAKELSLPYH-PRGTYV 161
F+ P P+D +F ++ Y +R+ ++ K++ GTYV
Sbjct: 140 GFSGQNPL------RGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYV 193
Query: 162 CTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGK 219
GP FET AE + + LG D VGM+ PE I+AR + +++TN S +
Sbjct: 194 MVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLE 253
Query: 220 KLTHSEVV---ELMNKKSKEIVALITKAIPLIPK 250
K H EV+ + +K ++ V+++ +IPL K
Sbjct: 254 KANHEEVLAAGKQAAQKLEQFVSILMASIPLPDK 287
>gb|AAA36460.1| (M13953) purine nucleoside phosphorylase [Homo sapiens]
Length = 289
Score = 77.6 bits (188), Expect = 1e-13
Identities = 74/274 (27%), Positives = 126/274 (45%), Gaps = 38/274 (13%)
Query: 3 RVAVIGGSG------------VYDFPA-ENKRSVTVETPYGKVEVTIGLVNGEEVAFLAR 49
+VA+I GSG ++D+ N TV G++ G +NG A +
Sbjct: 26 QVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRL--VFGFLNGR--ACVMM 81
Query: 50 HGKGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID-- 104
G+ H P K+ + ++ L LGV+ ++ T+A G +NP GD +++ I+
Sbjct: 82 QGRFHMYRGYPLWKVTFPVRVFHL--LGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLP 139
Query: 105 -FTVSRPRTFYDGEESPHDRKFVAHVD-FTEPYCPEIRRALIAAAKELSLPYH-PRGTYV 161
F+ P P+D +F ++ Y +R+ ++ K++ GTYV
Sbjct: 140 GFSGQNPL------RGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYV 193
Query: 162 CTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGK 219
GP FET AE + + LG D VGM+ PE I+AR + +++TN S +
Sbjct: 194 MVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLE 253
Query: 220 KLTHSEVV---ELMNKKSKEIVALITKAIPLIPK 250
K H EV+ + +K ++ V+++ +IPL K
Sbjct: 254 KANHEEVLAAGKQAAQKLEQFVSILMASIPLPDK 287
>gi|11437430 purine nucleoside phosphorylase [Homo sapiens]
Length = 289
Score = 77.6 bits (188), Expect = 1e-13
Identities = 72/273 (26%), Positives = 123/273 (44%), Gaps = 36/273 (13%)
Query: 3 RVAVIGGSG------------VYDFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARH 50
+VA+I GSG ++D+ E P + G +NG A +
Sbjct: 26 QVAIICGSGLGGLTDKLTQAQIFDY-GEIPNFPLYTVPGHAGRLVFGFLNGR--ACVMMQ 82
Query: 51 GKGH---SIPPHKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIID--- 104
G+ H P K+ + ++ L LGV+ ++ T+A G +NP GD +++ I+
Sbjct: 83 GRFHMYEGYPLWKVTFPVRVFHL--LGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPG 140
Query: 105 FTVSRPRTFYDGEESPHDRKFVAHVD-FTEPYCPEIRRALIAAAKELSLPYH-PRGTYVC 162
F+ P P+D +F ++ Y +R+ ++ K++ GTYV
Sbjct: 141 FSGQNPL------RGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVM 194
Query: 163 TEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTNYAA--GISGKK 220
GP FET AE + + LG D VGM+ PE I+AR + +++TN S +K
Sbjct: 195 VAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEK 254
Query: 221 LTHSEVV---ELMNKKSKEIVALITKAIPLIPK 250
H EV+ + +K ++ V+++ +IPL K
Sbjct: 255 ANHEEVLAAGKQAAQKLEQFVSILMASIPLPDK 287
>gb|AAF47653.1| (AE003475) CG16758 gene product [alt 4] [Drosophila melanogaster]
Length = 329
Score = 76.9 bits (186), Expect = 2e-13
Identities = 66/231 (28%), Positives = 106/231 (45%), Gaps = 18/231 (7%)
Query: 24 TVETPYGKVEVTIGLVNGEEVAFLARHGKGH---SIPPHKINYRANIWALYELGVERIIA 80
TVE G++ +G + G V +A G+ H P K + + L GVE + A
Sbjct: 100 TVEGHAGRL--VVGTLEGATV--MAMQGRFHFYEGYPLAKCSMPVRVMKL--CGVEYLFA 153
Query: 81 TSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPH-DRKFVAHVDFTEPYCPEI 139
T+A G +NP GD +++ ++ + G P +F A V+ Y ++
Sbjct: 154 TNAAGGINPRFAVGDIMLMHDHVNMLGFAGNSPLQGPNDPRFGPRFPALVN---SYNKDL 210
Query: 140 RRALIAAAKELSLPYHPR-GTYVCTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARE 198
I AK + + + G Y C GP +ET AE+KA R++G D VGM+ E I AR
Sbjct: 211 INKAIEIAKAMGIESNIHVGVYSCLGGPNYETIAELKALRMMGVDAVGMSTVHEVITARH 270
Query: 199 LEICYATVAIVTN-YAAGISGKK---LTHSEVVELMNKKSKEIVALITKAI 245
++ +++TN A S KK H EV+ + + K L+++ I
Sbjct: 271 CDMKVFAFSLITNKCATEYSDKKDDEANHDEVMAVAKNRQKACCELVSRLI 321
>gb|AAF47654.1| (AE003475) CG16758 gene product [alt 3] [Drosophila melanogaster]
Length = 353
Score = 76.9 bits (186), Expect = 2e-13
Identities = 66/231 (28%), Positives = 106/231 (45%), Gaps = 18/231 (7%)
Query: 24 TVETPYGKVEVTIGLVNGEEVAFLARHGKGH---SIPPHKINYRANIWALYELGVERIIA 80
TVE G++ +G + G V +A G+ H P K + + L GVE + A
Sbjct: 124 TVEGHAGRL--VVGTLEGATV--MAMQGRFHFYEGYPLAKCSMPVRVMKL--CGVEYLFA 177
Query: 81 TSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPH-DRKFVAHVDFTEPYCPEI 139
T+A G +NP GD +++ ++ + G P +F A V+ Y ++
Sbjct: 178 TNAAGGINPRFAVGDIMLMHDHVNMLGFAGNSPLQGPNDPRFGPRFPALVN---SYNKDL 234
Query: 140 RRALIAAAKELSLPYHPR-GTYVCTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARE 198
I AK + + + G Y C GP +ET AE+KA R++G D VGM+ E I AR
Sbjct: 235 INKAIEIAKAMGIESNIHVGVYSCLGGPNYETIAELKALRMMGVDAVGMSTVHEVITARH 294
Query: 199 LEICYATVAIVTN-YAAGISGKK---LTHSEVVELMNKKSKEIVALITKAI 245
++ +++TN A S KK H EV+ + + K L+++ I
Sbjct: 295 CDMKVFAFSLITNKCATEYSDKKDDEANHDEVMAVAKNRQKACCELVSRLI 345
>gb|AAF47655.1| (AE003475) CG16758 gene product [alt 2] [Drosophila melanogaster]
Length = 328
Score = 76.9 bits (186), Expect = 2e-13
Identities = 66/231 (28%), Positives = 106/231 (45%), Gaps = 18/231 (7%)
Query: 24 TVETPYGKVEVTIGLVNGEEVAFLARHGKGH---SIPPHKINYRANIWALYELGVERIIA 80
TVE G++ +G + G V +A G+ H P K + + L GVE + A
Sbjct: 99 TVEGHAGRL--VVGTLEGATV--MAMQGRFHFYEGYPLAKCSMPVRVMKL--CGVEYLFA 152
Query: 81 TSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPH-DRKFVAHVDFTEPYCPEI 139
T+A G +NP GD +++ ++ + G P +F A V+ Y ++
Sbjct: 153 TNAAGGINPRFAVGDIMLMHDHVNMLGFAGNSPLQGPNDPRFGPRFPALVN---SYNKDL 209
Query: 140 RRALIAAAKELSLPYHPR-GTYVCTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARE 198
I AK + + + G Y C GP +ET AE+KA R++G D VGM+ E I AR
Sbjct: 210 INKAIEIAKAMGIESNIHVGVYSCLGGPNYETIAELKALRMMGVDAVGMSTVHEVITARH 269
Query: 199 LEICYATVAIVTN-YAAGISGKK---LTHSEVVELMNKKSKEIVALITKAI 245
++ +++TN A S KK H EV+ + + K L+++ I
Sbjct: 270 CDMKVFAFSLITNKCATEYSDKKDDEANHDEVMAVAKNRQKACCELVSRLI 320
>gb|AAF47656.1| (AE003475) CG16758 gene product [alt 1] [Drosophila melanogaster]
Length = 267
Score = 76.9 bits (186), Expect = 2e-13
Identities = 66/231 (28%), Positives = 106/231 (45%), Gaps = 18/231 (7%)
Query: 24 TVETPYGKVEVTIGLVNGEEVAFLARHGKGH---SIPPHKINYRANIWALYELGVERIIA 80
TVE G++ +G + G V +A G+ H P K + + L GVE + A
Sbjct: 38 TVEGHAGRL--VVGTLEGATV--MAMQGRFHFYEGYPLAKCSMPVRVMKL--CGVEYLFA 91
Query: 81 TSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPH-DRKFVAHVDFTEPYCPEI 139
T+A G +NP GD +++ ++ + G P +F A V+ Y ++
Sbjct: 92 TNAAGGINPRFAVGDIMLMHDHVNMLGFAGNSPLQGPNDPRFGPRFPALVN---SYNKDL 148
Query: 140 RRALIAAAKELSLPYHPR-GTYVCTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARE 198
I AK + + + G Y C GP +ET AE+KA R++G D VGM+ E I AR
Sbjct: 149 INKAIEIAKAMGIESNIHVGVYSCLGGPNYETIAELKALRMMGVDAVGMSTVHEVITARH 208
Query: 199 LEICYATVAIVTN-YAAGISGKK---LTHSEVVELMNKKSKEIVALITKAI 245
++ +++TN A S KK H EV+ + + K L+++ I
Sbjct: 209 CDMKVFAFSLITNKCATEYSDKKDDEANHDEVMAVAKNRQKACCELVSRLI 259
>pir||T37901 probable purine nucleoside phosphorylase - fission yeast
(Schizosaccharomyces pombe) >gi|5912369|emb|CAB55857.1|
(AL117390) putative purine nucleoside phosphorylase
[Schizosaccharomyces pombe]
Length = 315
Score = 73.4 bits (177), Expect = 3e-12
Identities = 64/225 (28%), Positives = 103/225 (45%), Gaps = 20/225 (8%)
Query: 3 RVAVIGGSG-----------VYDFPAENKRSVTVE-TPYGKVEVTIGLVNGEEVAFLARH 50
+VA+I GSG VY+ P E+ V P ++ + + V +
Sbjct: 42 KVAIICGSGLGTLASGLSAPVYEVPYEDIPHFHVSHVPGHASKLYFAFLGEKRVPTMILA 101
Query: 51 GKGHSIPPHKINYRA-NIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSR 109
G+ HS + I + + +GVE ++ T+A G +N + GD +IL I+F
Sbjct: 102 GRYHSYEGYPIEATTFPVRLMKVMGVEVMVVTNAAGGLNQGFKVGDLMILKDHINFPGLA 161
Query: 110 PRTFYDGEESPHDRKF-VAHVDFTEPYCPEIRRALIAAAK--ELSLPYHPRGTYVCTEGP 166
G P+ +F V ++ Y E+R+ + AAK ++S H G Y GP
Sbjct: 162 GMNPLRG---PNAHEFGVRFPPLSDAYDLELRKLVYDAAKAHKVSRTIH-EGCYAFVSGP 217
Query: 167 RFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATVAIVTN 211
FET AE + ++G D VGM+ PE ++AR I +++VTN
Sbjct: 218 CFETRAESRMLALMGADCVGMSTVPEVVVARHCGIRVLAISLVTN 262
>pir||A42708 purine-nucleoside phosphorylase (EC 2.4.2.1) - Bacillus subtilis
(fragment)
Length = 114
Score = 69.1 bits (166), Expect = 5e-11
Identities = 37/99 (37%), Positives = 58/99 (58%), Gaps = 2/99 (2%)
Query: 147 AKELSLPYHPRGTYVCTEGPRFETAAEIKAYRILGGDVVGMTQCPEAILARELEICYATV 206
AK+L++P +G Y GP +ET AE++ R +G D VGM+ PE I+A + +
Sbjct: 13 AKDLNIPIQ-KGVYTDVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVANHAGMRVLAI 71
Query: 207 AIVTNYAAGISGKKLTHSEVVELMNKKSKEIVALITKAI 245
+ ++N AAGI + L+H EV+E+ K + L+ KAI
Sbjct: 72 SCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLV-KAI 109
>gi|6323238 Purine Nucleoside Phosphorylase; Pnp1p [Saccharomyces cerevisiae]
>gi|2494051|sp|Q05788|PNPH_YEAST PROBABLE PURINE
NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|626447|pir||S48560 purine-nucleoside phosphorylase
(EC 2.4.2.1) YLR209c - yeast (Saccharomyces cerevisiae)
>gi|544515|gb|AAB67440.1| (U14913) Ylr209c:
purine-nucleoside phosphorylase [Saccharomyces
cerevisiae]
Length = 311
Score = 68.7 bits (165), Expect = 7e-11
Identities = 69/246 (28%), Positives = 106/246 (43%), Gaps = 28/246 (11%)
Query: 14 DFPAENKRSVTVETPYGKVEVTIGLVNGEEVAFLARHGKGHSIPPHKI-NYRANIWALYE 72
D P K +V P + G +NG V + +G+ H + + I L
Sbjct: 69 DIPGFKKSTV----PGHSGTLMFGSMNGSPVVLM--NGRLHGYEGNTLFETTFPIRVLNH 122
Query: 73 LG-VERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEESPHDR-KFVAHVD 130
+G V +I T+A G +N + D + + ++ + G D +F+A
Sbjct: 123 MGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLA--- 179
Query: 131 FTEPYCPEIRRALIAAAKELSL--PYHPRGTYVCTEGPRFETAAEIKAYRILGGDVVGMT 188
++ Y E+R+ L KEL + P H GTY GP FET AE K R+LGGD VGM+
Sbjct: 180 LSDAYDLELRKLLFKKWKELKIQRPLH-EGTYTFVSGPTFETRAESKMIRMLGGDAVGMS 238
Query: 189 QCPEAILARELEICYATVAIVTNYA-------------AGISGKKLTHSEVVELMNKKSK 235
PE I+AR ++++TN + K TH+EV+E S
Sbjct: 239 TVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASN 298
Query: 236 EIVALI 241
++ LI
Sbjct: 299 DVQNLI 304
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.138 0.408
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101304955
Number of Sequences: 2977
Number of extensions: 4175323
Number of successful extensions: 8346
Number of sequences better than 1.0e-10: 62
Number of HSP's better than 0.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 8224
Number of HSP's gapped (non-prelim): 62
length of query: 265
length of database: 189,106,746
effective HSP length: 54
effective length of query: 211
effective length of database: 156,788,448
effective search space: 33082362528
effective search space used: 33082362528
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 164 (68.3 bits)