BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1675 (lysC-like2) DE:aspartate kinase related (lysC)
(352 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||A75081 aspartate kinase related (lysc) PAB1675 - Pyrococcus... 694 0.0
pir||F71136 hypothetical protein PH0858 - Pyrococcus horikoshii ... 357 1e-97
pir||C71103 probable aspartokinase - Pyrococcus horikoshii >gi|3... 264 1e-69
pir||B75081 aspartate kinase (lysc) related PAB1674 - Pyrococcus... 250 2e-65
sp|Q57991|AK_METJA PROBABLE ASPARTOKINASE (ASPARTATE KINASE) >gi... 133 3e-30
gi|11498307 aspartate kinase (lysC) [Archaeoglobus fulgidus] >gi... 125 6e-28
pir||B69207 aspartokinase II alpha subunit - Methanobacterium th... 121 1e-26
pir||E72715 probable aspartate kinase APE1140 - Aeropyrum pernix... 120 2e-26
pir||H82086 aspartokinase I/homoserine dehydrogenase, threonine-... 116 5e-25
pir||F75405 aspartate kinase - Deinococcus radiodurans (strain R... 115 1e-24
pir||DEECK thrA bifunctional enzyme - Escherichia coli >gi|53724... 114 1e-24
sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 113 2e-24
emb|CAA23660.1| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3] [... 112 6e-24
sp|P57290|AKH_BUCAI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR... 110 2e-23
gb|AAA24095.1| (M11812) aspartokinase III [Escherichia coli] 108 8e-23
sp|P08660|AK3_ECOLI LYSINE-SENSITIVE ASPARTOKINASE III (ASPARTAT... 108 8e-23
sp|O67221|AK_AQUAE ASPARTOKINASE (ASPARTATE KINASE) >gi|7434554|... 108 1e-22
sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR... 108 1e-22
gb|AAK41163.1| Aspartokinase (akH) [Sulfolobus solfataricus] 106 3e-22
dbj|BAA38477.1| (D10386) aspartokinase I-homoserine dehydrogenas... 106 4e-22
sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 106 4e-22
dbj|BAA38474.1| (D10385) aspartokinase I-homoserine dehydrogenas... 106 4e-22
dbj|BAA38480.1| (D10387) aspartokinase I-homoserine dehydrogenas... 106 4e-22
sp|O84367|AK_CHLTR ASPARTOKINASE (ASPARTATE KINASE) >gi|7448937|... 103 4e-21
dbj|BAB08285.1| (AB007650) lysine-sensitive aspartate kinase [Ar... 102 6e-21
pir||F82328 aspartokinase III, lysine-sensitive VC0391 [imported... 102 8e-21
sp|P41403|AK_MYCSM ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: A... 102 8e-21
gb|AAB63104.1| (U62020) lysine-sensitive aspartate kinase [Arabi... 100 4e-20
pir||D81681 aspartokinase III TC0641 [imported] - Chlamydia muri... 100 4e-20
pir||G81537 aspartokinase III CP0803 [imported] - Chlamydophila ... 99 5e-20
sp|Q9Z6L0|AK_CHLPN ASPARTOKINASE (ASPARTATE KINASE) >gi|7434556|... 99 7e-20
emb|CAC06395.1| (Y16255) aspartate kinase [Arabidopsis thaliana] 99 7e-20
pir||G72245 aspartokinase II - Thermotoga maritima (strain MSB8)... 99 9e-20
sp|P26512|AK_CORGL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: A... 98 1e-19
emb|CAA67376.1| (X98873) aspartate kinase [Arabidopsis thaliana] 98 1e-19
pir||T48575 aspartate kinase - Arabidopsis thaliana >gi|7529283|... 98 1e-19
sp|P41398|AK_CORFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: A... 96 5e-19
pir||G82583 bifunctional aspartokinase/homoserine dehydrogenase ... 96 6e-19
pir||C46665 aspartate kinase (EC 2.7.2.4) I - Bacillus subtilis ... 95 1e-18
sp|Q04795|AK1_BACSU ASPARTOKINASE 1 (ASPARTOKINASE I) (ASPARTATE... 95 1e-18
gb|AAD41796.1| (AF135862) precursor monofunctional aspartokinase... 95 1e-18
dbj|BAA95630.1| (AB042521) aspartate kinase [Oryza sativa] 95 1e-18
sp|O25827|AK_HELPY ASPARTOKINASE (ASPARTATE KINASE) >gi|7434553|... 95 1e-18
sp|P53553|AK2_BACST ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTAT... 95 1e-18
gb|AAD49567.1|AF134837_1 (AF134837) aspartokinase subunit A [Amy... 95 1e-18
sp|P97151|AK_THETH ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: A... 95 1e-18
gb|AAF03452.1|AC010797_28 (AC010797) putative aspartate kinase [... 95 1e-18
pir||A82311 aspartokinase, alpha and beta chains VC0547 [importe... 94 2e-18
sp|P77991|AK_THEFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: A... 94 2e-18
dbj|BAB06119.1| (AP001515) aspartokinase I (alpha and beta subun... 93 4e-18
sp|Q9ZJZ7|AK_HELPJ ASPARTOKINASE (ASPARTATE KINASE) >gi|7434552|... 93 5e-18
pir||C83531 aspartate kinase alpha and beta chain PA0904 [import... 92 1e-17
gb|AAB49995.1| (U90239) aspartokinase [Mycobacterium tuberculosis] 91 2e-17
sp|P97048|AK_MYCTU ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: A... 91 2e-17
sp|Q59229|AK2_BACSP ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTAT... 90 3e-17
dbj|BAB06815.1| (AP001517) aspartokinase II alpha and beta subun... 90 5e-17
sp|Q9ZCI7|AK_RICPR ASPARTOKINASE (ASPARTATE KINASE) >gi|7434558|... 89 6e-17
pir||T35383 probable aspartokinase - Streptomyces coelicolor >gi... 87 3e-16
pir||H81865 aspartate kinase (EC 2.7.2.4) NMA1701 [imported] - N... 87 3e-16
pir||E81405 aspartate kinase (EC 2.7.2.4) alpha and beta chains ... 86 7e-16
pir||T39822 aspartate kinase - fission yeast (Schizosaccharomyce... 86 7e-16
pir||F81076 aspartokinase, alpha and beta chains NMB1498 [import... 86 7e-16
dbj|BAB05219.1| (AP001512) homoserine dehydrogenase [Bacillus ha... 85 9e-16
emb|CAA99580.1| (Z75208) aspartokinase II alpha subunit [Bacillu... 82 8e-15
sp|P08495|AK2_BACSU ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTAT... 81 2e-14
emb|CAC11508.1| (AL445064) aspartate kinase related protein [The... 80 3e-14
pir||H72364 aspartokinase II - Thermotoga maritima (strain MSB8)... 80 4e-14
gb|AAG20470.1| (AE005119) aspartokinase II alpha subunit; LysC [... 79 7e-14
pir||S76764 hypothetical protein - Synechocystis sp. (strain PCC... 79 9e-14
pir||B82045 aspartokinase II/homoserine dehydrogenase, methionin... 77 3e-13
sp|P94417|AK3_BACSU PROBABLE ASPARTOKINASE (ASPARTATE KINASE) >g... 75 1e-12
pir||T04752 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge... 75 2e-12
sp|P00562|AK2H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 73 4e-12
emb|CAA23585.1| (V00305) aspartokinase II-homoserine dehydrogena... 73 4e-12
gb|AAA24165.1| (J01651) aspartokinase II-homoserine dehydrogenas... 72 1e-11
emb|CAB57346.1| (Y15939) aspartokinase [Dichelobacter nodosus] 71 2e-11
pir||T03589 probable aspartate kinase (EC 2.7.2.4) / homoserine ... 70 3e-11
sp|P49080|AKH2_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 69 1e-10
>pir||A75081 aspartate kinase related (lysc) PAB1675 - Pyrococcus abyssi
(strain Orsay) >gi|5458462|emb|CAB49950.1| (AJ248286)
aspartate kinase related (lysC) [Pyrococcus abyssi]
Length = 352
Score = 694 bits (1771), Expect = 0.0
Identities = 352/352 (100%), Positives = 352/352 (100%)
Query: 1 MVYKLLVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGAL 60
MVYKLLVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGAL
Sbjct: 1 MVYKLLVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGAL 60
Query: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKS 120
PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKS
Sbjct: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKS 120
Query: 121 KVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVTFGR 180
KVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVTFGR
Sbjct: 121 KVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVTFGR 180
Query: 181 GGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKA 240
GGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKA
Sbjct: 181 GGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKA 240
Query: 241 LHWKAVDPVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFVVGRNISLP 300
LHWKAVDPVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFVVGRNISLP
Sbjct: 241 LHWKAVDPVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFVVGRNISLP 300
Query: 301 GFLVEEEREDFVKIVVAREDLPEAIREIHREVVEREEKNLRTGNNSELWARI 352
GFLVEEEREDFVKIVVAREDLPEAIREIHREVVEREEKNLRTGNNSELWARI
Sbjct: 301 GFLVEEEREDFVKIVVAREDLPEAIREIHREVVEREEKNLRTGNNSELWARI 352
>pir||F71136 hypothetical protein PH0858 - Pyrococcus horikoshii
>gi|3257269|dbj|BAA29952.1| (AP000003) 359aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 359
Score = 357 bits (906), Expect = 1e-97
Identities = 190/359 (52%), Positives = 253/359 (69%), Gaps = 13/359 (3%)
Query: 1 MVYKLLVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGAL 60
MV K +V+KFGG+SVRYAFEEALELV L E + I+VVVSAL GVTD L+R A GDK AL
Sbjct: 1 MVEKPVVIKFGGTSVRYAFEEALELVAKLHENMKIIVVVSALAGVTDCLLRLAKGDKSAL 60
Query: 61 PRIERIHEEF-------LNYHGLNTKISISFRKDMPPE-ALRDEIISLGERISAKIFAEG 112
I+ IHEE L + K +I+ + P E A DEI S GER SAK+F+EG
Sbjct: 61 LEIDEIHEELSQELNVQLEHLIHQLKKTINSKSSFPSEKAFIDEIASFGERFSAKLFSEG 120
Query: 113 LELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLN 172
L++LGI ++ VD + L KGEFG+A + ++S + L R+++ G++PV+ G+YGNLN
Sbjct: 121 LKILGITARPVDSKDVLFVKGEFGNAEVEFKKSAQGVDVLYRMLRRGIVPVVTGYYGNLN 180
Query: 173 GFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKV 232
GFR TFGRGGSDYSAT++A +++++ VLIMSDVEGI+TADPKLVP ARLI Y+SY+E K
Sbjct: 181 GFRATFGRGGSDYSATSIASLVNAKAVLIMSDVEGIYTADPKLVPPARLIHYISYKEAKT 240
Query: 233 AAKLGMKALHWKAVDPVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFV 292
AAKLGMK LH +A+DPV G IP+I GKT+D KFGT++ + PI+ H++ E+ AEI V
Sbjct: 241 AAKLGMKVLHPRAIDPVEGKIPVILGKTRDLKFGTLISHESQGIPIVTHKLLENHAEISV 300
Query: 293 VG--RNISLPGFLVEEEREDFVKIVVAREDLPEAIREIHREVVEREEKNLRTGNNSELW 349
V NI LP + V EE + + KI +++ E +R++HR VVE E NL + ++ ELW
Sbjct: 301 VSVKTNIPLP-YEVYEEGDLYFKIKTSKDQFLEVLRDVHRRVVENE--NLHSSHDGELW 356
>pir||C71103 probable aspartokinase - Pyrococcus horikoshii
>gi|3257502|dbj|BAA30185.1| (AP000004) 346aa long
hypothetical aspartokinase [Pyrococcus horikoshii]
Length = 346
Score = 264 bits (668), Expect = 1e-69
Identities = 146/345 (42%), Positives = 219/345 (63%), Gaps = 18/345 (5%)
Query: 4 KLLVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANG-DKGALPR 62
K++V+KFGGSS+R F+ A+ L+K LSE +VVVVSALKG+TD L ++ + D
Sbjct: 6 KMIVIKFGGSSLRSEFKSAVSLIKALSEEKDVVVVVSALKGITDLLEKYTDTFDSRYAVE 65
Query: 63 IERIHEEFLNYHGLNTKISISFRK------DMPPEALRDEIISLGERISAKIFAEGLELL 116
+ + + EF G++T + K D+PP+ALRD I+S+GE +SA + AE
Sbjct: 66 VSKTYLEFGKRMGIDTSSLSPYLKQLFNPPDLPPQALRDYILSIGELLSAAMIAEKAN-- 123
Query: 117 GIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRV 176
V+ P + +A G FG+ +I+I++SKR + ++SG IP+IPGF NLNG+RV
Sbjct: 124 ---GAVIFPWDLFVAHGSFGNGFIDIKKSKRNVKLVKEALESGKIPIIPGFIANLNGYRV 180
Query: 177 TFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKL 236
T GRGGSDYSA AL +L+S V IMSDVEGIFTADPK++P + LIPY+SY+EI +A+K
Sbjct: 181 TLGRGGSDYSAVALGVLLNSELVAIMSDVEGIFTADPKMIPYSLLIPYMSYDEILIASKY 240
Query: 237 GMKALHWKAVDPVVG-DIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFVVGR 295
GM+A+ WKA + I+FG+ DW+ GT+V N+ S+ P++ + D ++ V+
Sbjct: 241 GMEAIQWKAAKLAKEYEALILFGRASDWRMGTVVSNSSSHMPLLSY----DQGKLLVMNM 296
Query: 296 NISLPGFLVEEEREDFVKIVVAREDLPEAIREIHREVVEREEKNL 340
+ +P + V EE E + V + D + I+E+HR+++ +E L
Sbjct: 297 DSEIP-YEVVEEGEFWRVYRVPKRDSIKIIKELHRKIIYQENAQL 340
>pir||B75081 aspartate kinase (lysc) related PAB1674 - Pyrococcus abyssi
(strain Orsay) >gi|5458463|emb|CAB49951.1| (AJ248286)
aspartate kinase (lysC) related [Pyrococcus abyssi]
Length = 368
Score = 250 bits (631), Expect = 2e-65
Identities = 136/287 (47%), Positives = 192/287 (66%), Gaps = 13/287 (4%)
Query: 4 KLLVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANG-DKGALPR 62
K++V+KFGGSSV+ F EA+ L K + E + VVVSALKG+TD LI++A D +
Sbjct: 3 KMIVLKFGGSSVKNDFHEAVSLTKSIFEEKEVAVVVSALKGITDMLIKYAKTFDSKYAIK 62
Query: 63 IERIHEEFLNYHGLNTKISISFRKDM------PPEALRDEIISLGERISAKIFAEGLELL 116
I + +F +G++ I +++ P +AL D I+S+GE +SA IFAE +E
Sbjct: 63 IADSYVKFARTNGVDPNILSPHIQELFNPPSLPKDALTDYILSIGELLSAVIFAEVVE-- 120
Query: 117 GIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRV 176
+V+ P E A G+FGD +I++++SK+ A + +I SG IP++PGF G ++G+RV
Sbjct: 121 ---GQVIYPWELFSAYGKFGDGFIDLKKSKKNAKIIYEVIDSGKIPIVPGFVGGMDGYRV 177
Query: 177 TFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKL 236
T GRGGSDYSA AL IL+S V IMS+VEGIFTADPKLVPSARLIPYLSYEE +AAK
Sbjct: 178 TLGRGGSDYSAVALGVILNSELVAIMSNVEGIFTADPKLVPSARLIPYLSYEEALIAAKH 237
Query: 237 GMKALHWKAVD-PVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHR 282
GMKA+ WKA + I ++FG+T +W+ GT++ N S P++ ++
Sbjct: 238 GMKAIQWKAAELAKEKKILMLFGRTNNWRMGTVISNRTSRMPLMTYK 284
>sp|Q57991|AK_METJA PROBABLE ASPARTOKINASE (ASPARTATE KINASE) >gi|2127773|pir||C64371
aspartate kinase (EC 2.7.2.4) I - Methanococcus
jannaschii >gi|1591278|gb|AAB98565.1| (U67506) aspartate
kinase (lysC) [Methanococcus jannaschii]
Length = 473
Score = 133 bits (332), Expect = 3e-30
Identities = 121/395 (30%), Positives = 191/395 (47%), Gaps = 62/395 (15%)
Query: 7 VVKFGGSSVRYAFEEALELVKYLSERIP----IVVVVSALKGVTDELIRFAN-------- 54
V+KFGG+SV E + K +++R +VVVVSA+ VT+ L+ +
Sbjct: 4 VMKFGGTSVGSG-ERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDI 62
Query: 55 ---GD--KGALPRIERIHEEFLNYHGLNTK----------------ISISFRKDMPPEAL 93
GD K + + EE + + + I +++ ++ P++
Sbjct: 63 AKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKS- 121
Query: 94 RDEIISLGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKL 152
RD I+S GER+S+ I + + LG KS ++ E +I FG A + E K R L
Sbjct: 122 RDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKER---L 178
Query: 153 IRLIKSGVIPVIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTA 211
+ L+K G+IPV+ GF G G+ T GRGGSDYSA + LD+ + I +DV G++T
Sbjct: 179 LPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTT 238
Query: 212 DPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKT-KDWKFGTIV 269
DP+LVP+AR IP LSY E A G K LH + ++P + IPI+ T + GT++
Sbjct: 239 DPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLI 298
Query: 270 LNARSNFPIIVHRVR--EDFAEIFVVGRN-ISLPG-------FLVEEE----------RE 309
N IV + ++ A I + G + + G L EEE E
Sbjct: 299 TNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSE 358
Query: 310 DFVKIVVAREDLPEAIREIHREVVEREEKNLRTGN 344
+ +VV+ ED+ +A++ + RE + +K+ N
Sbjct: 359 TNISLVVSEEDVDKALKALKREFGDFGKKSFLNNN 393
>gi|11498307 aspartate kinase (lysC) [Archaeoglobus fulgidus]
>gi|7448935|pir||D69337 aspartate kinase (lysC) homolog
- Archaeoglobus fulgidus >gi|2649914|gb|AAB90539.1|
(AE001056) aspartate kinase (lysC) [Archaeoglobus
fulgidus]
Length = 462
Score = 125 bits (312), Expect = 6e-28
Identities = 114/358 (31%), Positives = 168/358 (46%), Gaps = 78/358 (21%)
Query: 6 LVVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANG-------- 55
+V+KFGG SV+ LVK SE +VVVVSA++GVTD L++ A+
Sbjct: 3 IVMKFGGVSVKDGENIYHCANLVKKFSEGNEVVVVVSAMQGVTDALLKAAHRCCSEPSAG 62
Query: 56 -DKGALPRIERIHEEFLNYHGLNTKI--------------------SISFRKDMPPEALR 94
K + + + H E + Y N +I IS+ ++ +
Sbjct: 63 FIKMFIADMMKRHYEAIEYAVRNDEIKAKVIAAVERLLDELEKVLLGISYLGELTRRS-E 121
Query: 95 DEIISLGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDA------YINIQESKR 147
D I+S GER+SA IF+ L LG+ S + + +I FG A Y I +
Sbjct: 122 DYIVSFGERLSAPIFSAALLSLGVDSVALTGGDAGIITDRNFGRAKPLPGVYTTI---RN 178
Query: 148 RAGKLIRLIKSGVIPVIPGFYGNL-NGFRVTFGRGGSDYSATALARILDSRCVLIMSDVE 206
R L+ + K+ IPV+ GF G +G T GRGGSDY+AT LA LD+ V + +V+
Sbjct: 179 RLEPLLTIKKT--IPVVTGFIGATDDGSITTLGRGGSDYTATILAAALDADEVWLWKEVD 236
Query: 207 GIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVGDIPIIFGKTKDWKFG 266
GI T DPK VP+AR+IP +SY+E + G K LH +A++PV+
Sbjct: 237 GIMTCDPKYVPNARVIPEISYQEAMELSHFGAKILHPRALEPVM---------------- 280
Query: 267 TIVLNARSNFPIIVHRVREDFAEIFVVGRNISLPGFLVEEEREDFVKIVVAREDLPEA 324
R N P+ R++ F N PG ++ +D +IV A +P+A
Sbjct: 281 ------RKNIPV---RIKNTF--------NPDAPGTVIGPTTKDSSEIVKALSLIPQA 321
>pir||B69207 aspartokinase II alpha subunit - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621892|gb|AAB85302.1| (AE000858) aspartokinase II
alpha subunit [Methanobacterium thermoautotrophicum]
Length = 406
Score = 121 bits (301), Expect = 1e-26
Identities = 101/361 (27%), Positives = 170/361 (46%), Gaps = 55/361 (15%)
Query: 4 KLLVVKFGGSSV---RYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGAL 60
+L+V KFGG+S+ R + A +VK + +VVVVSA+ TDEL++ +
Sbjct: 2 ELIVAKFGGTSIGNGRRIKKAARSVVKEYMKGRKVVVVVSAINKTTDELLQIVD------ 55
Query: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKS 120
+D E EI+S+GE S +IF+ +E LG+KS
Sbjct: 56 ----------------------EAMEDAVTEKQLAEIVSMGEMTSVRIFSSAIEALGVKS 93
Query: 121 KVVDPLEF---LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRV 176
+ +DP +I +A ++ + ++ ++ +L++L+ G+IPV+ GF G + NG+
Sbjct: 94 EYIDPFMDEWPIITDSNLLNAKVDFEATEEKSRELLKLLDQGIIPVVCGFLGRDPNGYIT 153
Query: 177 TFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKL 236
T GRGGSD +A L L + V+I++DV G+ + DP + A+ + +S EE++ A
Sbjct: 154 TLGRGGSDITAFLLGHCLKADEVIIVTDVGGVMSTDPNKLQGAKKLDKISVEEMRDLATH 213
Query: 237 GMKALHWKAV---DPVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVRED-FAEIFV 292
G + LH A+ DP + I F GT ++ N + + D + + V
Sbjct: 214 GAQVLHPHALKYKDPDIKAKIIGFEHGDLSAPGTEIIGPSKNKMVKTTTLNPDPISVVAV 273
Query: 293 VGRNI-SLPGFLVE---------------EEREDFVKIVVAREDLPEAIREIHREVVERE 336
VG I + PG L ++ V I V ++D EA R +H V+ +
Sbjct: 274 VGEKILNKPGILARLTSRLAENSINIIGISTGQNSVTIFVDKKDADEAHRLLHDVVIADD 333
Query: 337 E 337
+
Sbjct: 334 D 334
>pir||E72715 probable aspartate kinase APE1140 - Aeropyrum pernix (strain K1)
>gi|5104810|dbj|BAA80125.1| (AP000060) 473aa long
hypothetical aspartate kinase [Aeropyrum pernix]
Length = 473
Score = 120 bits (298), Expect = 2e-26
Identities = 114/378 (30%), Positives = 177/378 (46%), Gaps = 67/378 (17%)
Query: 5 LLVVKFGGSSVRYA--FEEALELVKYLSER-IPIVVVVSALKGVTDELIR-FANGDKGAL 60
L+VVKFGGS + + F A LV L E + VVVVSA+KGVTD L+ F D G
Sbjct: 27 LVVVKFGGSVLNGSPGFLAAGRLVLGLLESGLEPVVVVSAVKGVTDALLSSFERRDPGVG 86
Query: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDE------------------------ 96
+ + T +SI+ +PPE++RD
Sbjct: 87 GAVGK------------TYLSIARELGLPPESVRDVSLASAEVSKLLWAAEVLGQWTPRV 134
Query: 97 ---IISLGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDA--YINIQESKRRAG 150
++S GER+SA + A L LG++++ + E ++ GEFGDA E R
Sbjct: 135 RDLVVSYGERLSAALMAGLLRRLGVEARWLGGGEAGIVTDGEFGDATPLYGYTEGVIRE- 193
Query: 151 KLIRLIKSGVIPVIPGFYG-NLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIF 209
+L +++ GV+PV+ GF G G GRGGSD +AT LA L + V++ +DV GI
Sbjct: 194 RLEPMLEEGVVPVVAGFTGATREGDTTLLGRGGSDLTATLLASALGAGRVVLYTDVPGIL 253
Query: 210 TADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKTKDWKFGTI 268
+ DP++V R + Y+SYEE A+LG++ H + +P++ G + + + T
Sbjct: 254 SGDPRVVGEPRRVGYMSYEEAWEVARLGLRKFHPRTFEPLIAGGLGVEVVVSDLRGRSTR 313
Query: 269 VLNARSNFPIIVHRVREDFAEIFVVGRNIS--------LPGFLV----------EEERED 310
+ R P+ V + A + V G +++ L G L + E
Sbjct: 314 IGPGRGGPPLKVVSLSRGVARLVVRGPSMAGKRGFLSRLAGLLAGRGVNILAIRQPPSET 373
Query: 311 FVKIVVAREDLPEAIREI 328
+++VV DLP A+ E+
Sbjct: 374 AIELVVDERDLPAAVEEL 391
>pir||H82086 aspartokinase I/homoserine dehydrogenase, threonine-sensitive
VC2364 [imported] - Vibrio cholerae (group O1 strain
N16961) >gi|9656933|gb|AAF95507.1| (AE004306)
aspartokinase I/homoserine dehydrogenase,
threonine-sensitive [Vibrio cholerae]
Length = 825
Score = 116 bits (287), Expect = 5e-25
Identities = 81/276 (29%), Positives = 137/276 (49%), Gaps = 38/276 (13%)
Query: 7 VVKFGGSSVR--YAFEEALELVKYLSERIPIVVVVSALKGVTDELIR------------- 51
V+KFGGSS+ F A +++ +++ + VV+SA T++L+
Sbjct: 9 VLKFGGSSLADPERFLRAADIIANNAQQEEVAVVLSAPGKTTNKLVAVIESALRQGEVEA 68
Query: 52 -----------FANGDKGALPRIE------RIHEEFLNYHGLNTKISISFRKDMPPEALR 94
+G K LP ++ ++H I++ M P+ +
Sbjct: 69 QIVELESSFYALLDGIKAQLPNLDDSAYQQQVHSSMTQLRQFVHGITLL---GMCPDNVN 125
Query: 95 DEIISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIR 154
IIS GER+S ++ +E G+ + +VDP+++L+AKG+ +A ++++ S +R +
Sbjct: 126 ARIISKGERVSIQLMKAVMEAKGLPANLVDPVKYLLAKGDHLEAMVDVEISTQRFRQAP- 184
Query: 155 LIKSGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADP 213
+ + ++PGF GN G V GR GSDYSA LA L + C I +DV+G++ DP
Sbjct: 185 -LPQQHVNIMPGFTAGNAQGELVCLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDP 243
Query: 214 KLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV 249
+LV ARL+ LSY+E + G LH K + P+
Sbjct: 244 RLVDDARLLKSLSYQEAMELSYFGASVLHPKTIAPI 279
>pir||F75405 aspartate kinase - Deinococcus radiodurans (strain R1)
>gi|6459119|gb|AAF10936.1|AE001982_10 (AE001982)
aspartate kinase [Deinococcus radiodurans]
Length = 473
Score = 115 bits (284), Expect = 1e-24
Identities = 94/307 (30%), Positives = 151/307 (48%), Gaps = 34/307 (11%)
Query: 4 KLLVVKFGGSSVR--YAFEEALELV-KYLSERIPIVVVVSALKGVTDELIRFANG----- 55
+LLV+KFGG++++ +A + L + + E + +VVVVSA+ GVT+ L+ A+
Sbjct: 9 RLLVMKFGGTNMQSAHAIRHSASLAGRSVREGVKVVVVVSAMAGVTNGLLHLADAAQSGD 68
Query: 56 --------------------DKGALPRIERIHEEFLNYHGLNTKI-SISFRKDMPPEALR 94
+ GA P E + E + L + + +++ P + R
Sbjct: 69 IARANDEIAALRTRHFTAAQELGAAPDSETVRELRELHETLRQAVYGVYLLRELTPRS-R 127
Query: 95 DEIISLGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLI 153
D I++ GER+SA + + LE G++++ + E ++ FG+A +R +L
Sbjct: 128 DLIVAFGERLSAPLMSLALEQSGLRARHLTGGEAGILTDTNFGNARPLPGTYERVGDRLS 187
Query: 154 RLIKSGVIPVIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTAD 212
+ +GV PVI GF G G T GRGG+D+SAT + + L + V DV+G+ +AD
Sbjct: 188 GFLSAGVTPVIAGFMGETEQGAITTLGRGGTDFSATIVGKALGADEVWAWKDVDGVMSAD 247
Query: 213 PKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKTKDWKF-GTIVL 270
P++V A I LSY E+ A G K LH AV P+ IP+ D F GT+V
Sbjct: 248 PRVVGDASNIGVLSYGEVMELAYFGAKVLHPLAVTPLQDSGIPLRVKSAADPDFAGTLVR 307
Query: 271 NARSNFP 277
+ P
Sbjct: 308 SQAEEIP 314
>pir||DEECK thrA bifunctional enzyme - Escherichia coli
>gi|537245|gb|AAA97301.1| (U14003) aspartokinase
I-homoserine dehydrogenase I [Escherichia coli]
>gi|1786183|gb|AAC73113.1| (AE000111) aspartokinase I,
homoserine dehydrogenase I [Escherichia coli K12]
Length = 820
Score = 114 bits (283), Expect = 1e-24
Identities = 90/285 (31%), Positives = 138/285 (47%), Gaps = 33/285 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---GDKGALP 61
V+KFGG+SV A F ++++ + + + V+SA +T+ L+ + ALP
Sbjct: 3 VLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDALP 62
Query: 62 RI---ERIHEEFLN----------YHGLNTKISISFRK-----------DMPPEALRDEI 97
I ERI E L L T + F + P+++ +
Sbjct: 63 NISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINAAL 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIK 157
I GE++S I A LE G V+DP+E L+A G + ++ ++I ES RR I
Sbjct: 123 ICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAA--SRIP 180
Query: 158 SGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+ + ++ GF GN G V GR GSDYSA LA L + C I +DV+G++T DP+ V
Sbjct: 181 ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV 240
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKT 260
P ARL+ +SY+E + G K LH + + P+ IP + T
Sbjct: 241 PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNT 285
>sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
[INCLUDES: ASPARTOKINASE I ; HOMOSERINE DEHYDROGENASE I
]
Length = 820
Score = 113 bits (281), Expect = 2e-24
Identities = 90/285 (31%), Positives = 137/285 (47%), Gaps = 33/285 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---GDKGALP 61
V+KFGG+SV A F ++++ + + + V+SA +T+ L+ + ALP
Sbjct: 3 VLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDALP 62
Query: 62 RI---ERIHEEFLN----------YHGLNTKISISFRK-----------DMPPEALRDEI 97
I ERI E L L T + F + P+++ +
Sbjct: 63 NISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINAAL 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIK 157
I GE++S I A LE G V+DP+E L+A G + ++ ++I ES RR I
Sbjct: 123 ICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAA--SRIP 180
Query: 158 SGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+ + ++ GF GN G V GR GSDYSA LA L + C I +DV G++T DP+ V
Sbjct: 181 ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVNGVYTCDPRQV 240
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKT 260
P ARL+ +SY+E + G K LH + + P+ IP + T
Sbjct: 241 PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNT 285
>emb|CAA23660.1| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3] [Escherichia coli]
>gi|147979|gb|AAA83914.1| (J01706) aspartokinase
I-homoserine dehydrogenase I [Escherichia coli]
>gi|216435|dbj|BAA01286.1| (D10483) aspartokinase I
[Escherichia coli]
Length = 820
Score = 112 bits (278), Expect = 6e-24
Identities = 89/285 (31%), Positives = 137/285 (47%), Gaps = 33/285 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---GDKGALP 61
V+KFGG+S+ A F ++++ + + + V+SA +T+ L+ + ALP
Sbjct: 3 VLKFGGTSLANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDALP 62
Query: 62 RI---ERIHEEFLN----------YHGLNTKISISFRK-----------DMPPEALRDEI 97
I ERI E L L T + F + P+++ +
Sbjct: 63 NISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINAAL 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIK 157
I GE++S I A LE G V+DP+E L+A G + ++ ++I ES RR I
Sbjct: 123 ICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAA--SRIP 180
Query: 158 SGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+ + ++ GF GN G V GR GSDYSA LA L + C I +DV G++T DP+ V
Sbjct: 181 ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVNGVYTCDPRQV 240
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKT 260
P ARL+ +SY+E + G K LH + + P+ IP + T
Sbjct: 241 PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNT 285
>sp|P57290|AKH_BUCAI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE (AK-HD)
[INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
>gi|10038876|dbj|BAB12911.1| (AP001118) aspartokinase I
/ homoserine dehydrogenase I [Buchnera sp. APS]
Length = 816
Score = 110 bits (273), Expect = 2e-23
Identities = 85/295 (28%), Positives = 144/295 (48%), Gaps = 33/295 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALPRIE 64
++KFGG+S+ A F +++ ++ I VV+SA +T+ L++ +E
Sbjct: 3 LLKFGGTSLANAEKFLSVSSIIEENTQTDQIAVVLSAPAKITNYLVKIIENTIKNNQILE 62
Query: 65 RIH----------EEFLN-----------------YHGLNTKISISFRKDMPPEALRDEI 97
+H FLN ++ L I P+ +R I
Sbjct: 63 TVHLAENIFMQLINNFLNIQSNFPHKEIEKIIKKEFNELKNIIQGILLLKQCPDNIRAII 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGE-FGDAYINIQESKRRAGKLIRLI 156
IS GE +S I L+ +++P++ L+A G+ + D+ ++I ESK+ + +
Sbjct: 123 ISRGEILSVFIMKSILQSKNYNVTIINPVKNLVAIGDNYLDSTVDISESKKNIQNM-NIN 181
Query: 157 KSGVIPVIPGFYGNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+S +I + GN + V GR GSDYSA LA LD+ C I +DV+G+FT+DP+ V
Sbjct: 182 QSNIILMAGFIAGNKDKKLVVLGRNGSDYSAAVLAACLDANCCEIWTDVDGVFTSDPRKV 241
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKTKDWK-FGTIV 269
P+ARL+ +SY+E + G K LH + ++P+ IP + T + K GT++
Sbjct: 242 PNARLLKSISYQEAMELSYFGAKVLHPRTIEPIAQFKIPCLIKNTNNVKSIGTLI 296
>gb|AAA24095.1| (M11812) aspartokinase III [Escherichia coli]
Length = 449
Score = 108 bits (268), Expect = 8e-23
Identities = 94/299 (31%), Positives = 147/299 (48%), Gaps = 27/299 (9%)
Query: 4 KLLVVKFGGSSVRY--AFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDK---- 57
+++V KFGG+SV A + ++V LS+ +VV+SA G+T+ L+ A G +
Sbjct: 3 EIVVSKFGGTSVADFDAMNRSADIV--LSDANVRLVVLSASAGITNLLVALAEGLEPCER 60
Query: 58 ----GALPRIERIHEEFLNYHGL----------NTKISISFRKDMPPEALRDEIISLGER 103
A+ I+ E L Y + N + AL DE++S GE
Sbjct: 61 FEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGEL 120
Query: 104 ISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAG-KLIRLIKSGVIP 162
+S +F E L ++++ D + + FG A +I A +L+ + G++
Sbjct: 121 MSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLV- 179
Query: 163 VIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARL 221
+ GF G+ N G T GRGGSDY+A LA L + V I +DV GI+T DP++V +A+
Sbjct: 180 ITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKR 239
Query: 222 IPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKTKDWKF-GTIVLNARSNFPI 278
I +++ E A G K LH + P V DIP+ G +KD + GT+V N N P+
Sbjct: 240 IDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPL 298
>sp|P08660|AK3_ECOLI LYSINE-SENSITIVE ASPARTOKINASE III (ASPARTATE KINASE III)
>gi|7428061|pir||KIECD3 aspartate kinase (EC 2.7.2.4)
III, lysine-sensitive - Escherichia coli
>gi|396359|gb|AAC43118.1| (U00006) aspartokinase III
[Escherichia coli] >gi|1790455|gb|AAC76994.1| (AE000475)
aspartokinase III, lysine sensitive [Escherichia coli
K12]
Length = 449
Score = 108 bits (268), Expect = 8e-23
Identities = 94/299 (31%), Positives = 147/299 (48%), Gaps = 27/299 (9%)
Query: 4 KLLVVKFGGSSVRY--AFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDK---- 57
+++V KFGG+SV A + ++V LS+ +VV+SA G+T+ L+ A G +
Sbjct: 3 EIVVSKFGGTSVADFDAMNRSADIV--LSDANVRLVVLSASAGITNLLVALAEGLEPGER 60
Query: 58 ----GALPRIERIHEEFLNYHGL----------NTKISISFRKDMPPEALRDEIISLGER 103
A+ I+ E L Y + N + AL DE++S GE
Sbjct: 61 FEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGEL 120
Query: 104 ISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAG-KLIRLIKSGVIP 162
+S +F E L ++++ D + + FG A +I A +L+ + G++
Sbjct: 121 MSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLV- 179
Query: 163 VIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARL 221
+ GF G+ N G T GRGGSDY+A LA L + V I +DV GI+T DP++V +A+
Sbjct: 180 ITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKR 239
Query: 222 IPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKTKDWKF-GTIVLNARSNFPI 278
I +++ E A G K LH + P V DIP+ G +KD + GT+V N N P+
Sbjct: 240 IDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPL 298
>sp|O67221|AK_AQUAE ASPARTOKINASE (ASPARTATE KINASE) >gi|7434554|pir||B70399
aspartokinase - Aquifex aeolicus
>gi|2983613|gb|AAC07182.1| (AE000726) aspartokinase
[Aquifex aeolicus]
Length = 415
Score = 108 bits (267), Expect = 1e-22
Identities = 84/250 (33%), Positives = 126/250 (49%), Gaps = 41/250 (16%)
Query: 4 KLLVVKFGGSSVRYAFEEALEL-----VKYLSERIPIVVVVSALKGVTDELIRFANGDKG 58
K+LV KFGG+SV E +EL +K L + VVV SA+ G TD LI A
Sbjct: 2 KILVQKFGGTSVGTL--ERIELCAKRVIKALEKGYKPVVVSSAMAGETDSLIELA----- 54
Query: 59 ALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGI 118
+++H PPE D ++++GE+ + +FA L LG
Sbjct: 55 -----KKVHPR-------------------PPEREMDTLLAVGEQKAIALFAMTLNKLGY 90
Query: 119 KSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVT- 177
+ + + I + + + K +L+ LI+ G IPV+ GF G + +T
Sbjct: 91 PAVSLCGWQVPIITD---NVHTKARIRKIGISRLLSLIEEGYIPVVAGFQGVTEDWEITT 147
Query: 178 FGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLG 237
GRGGSD +A ALA L + C I +DV G+FTADP++VP+A+ I +SYEE+ A LG
Sbjct: 148 LGRGGSDTTAVALAAALKADCE-INTDVPGVFTADPRIVPNAKKIKKISYEEMLELASLG 206
Query: 238 MKALHWKAVD 247
K + ++V+
Sbjct: 207 AKVMQIRSVE 216
>sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE (AK-HD)
[INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
>gi|1073872|pir||A64048 aspartate kinase (EC 2.7.2.4) I
/ homoserine dehydrogenase (EC 1.1.1.3) - Haemophilus
influenzae (strain Rd KW20) >gi|1573040|gb|AAC21767.1|
(U32694) aspartokinase I / homoserine dehydrogenase I
(thrA) [Haemophilus influenzae Rd]
Length = 815
Score = 108 bits (267), Expect = 1e-22
Identities = 85/286 (29%), Positives = 136/286 (46%), Gaps = 35/286 (12%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALPRIE 64
V+KFGG+S+ F +A +L++ V+SA +T+ L+ A +K AL +
Sbjct: 3 VLKFGGTSLANPERFSQAAKLIEQAHLEEQAAGVLSAPAKITNHLV--ALSEKAALNQST 60
Query: 65 RIH-----EEFLNY----HGLNTKISISFRKDM--------------------PPEALRD 95
H E F N H N + ++ K + +A++
Sbjct: 61 DTHFNEAIEIFYNIINGLHTENNQFDLNGTKALIDAEFVQIKGLLEEIRQAGKVEDAVKA 120
Query: 96 EIISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRL 155
I GE++S + E G +VDP++ L+AKG + ++ + I+ES +R +
Sbjct: 121 TIDCRGEKLSIAMMKAWFEARGYSVHIVDPVKQLLAKGGYLESSVEIEESTKRVDAA-NI 179
Query: 156 IKSGVIPVIPGFYGNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKL 215
K V+ + GN G V GR GSDYSA LA L + I +DV+G++T DP+L
Sbjct: 180 AKDKVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASVCEIWTDVDGVYTCDPRL 239
Query: 216 VPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKT 260
VP ARL+P LSY E + G K +H + + P++ +IP + T
Sbjct: 240 VPDARLLPTLSYREAMELSYFGAKVIHPRTIGPLLPQNIPCVIKNT 285
>gb|AAK41163.1| Aspartokinase (akH) [Sulfolobus solfataricus]
Length = 446
Score = 106 bits (263), Expect = 3e-22
Identities = 88/278 (31%), Positives = 140/278 (49%), Gaps = 30/278 (10%)
Query: 6 LVVKFGGSSVRYAFEEALELVK---YLSERIPIVVVVSALKGVTDELIRFANGDKGALPR 62
L+VK GGS + + L + K + + I+VV SA+K VT+ELI + +
Sbjct: 3 LIVKIGGSIQKDEKDYELIVKKIQDFSKKSDKIIVVTSAIKNVTNELISATSNTDNSPNI 62
Query: 63 IERIHEE-----------------FLNYHGLNTKI-----SISFRKDMPPEALRDEIISL 100
+ I+E F + L+ ++ SI ++ P +RD I+S
Sbjct: 63 VTEIYERHIKLLSKLADGKEFENSFKDISRLSDELFRVAWSIRVLDEVTPR-VRDYILSF 121
Query: 101 GERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGV 160
GER++ + + L GI+++ + FL + +G+A + SK ++ K+ V
Sbjct: 122 GERMATLLLSAILRSNGIEAEGIITPPFLTDEN-YGEANVIEDLSKNEIANILENAKANV 180
Query: 161 IPVIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSA 219
I V+PGF G G T GRGGSDY+AT L +++ R V ++++V GI T DPK +A
Sbjct: 181 I-VLPGFIGRTREGRYTTLGRGGSDYTATLLGKLVGVREVRLVTEVPGIMTGDPKKFENA 239
Query: 220 RLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPII 256
+ I LS EE ++LG K LH + DPV G D+ +I
Sbjct: 240 KTISRLSLEEAIELSQLGAKRLHPRTFDPVFGSDMKVI 277
>dbj|BAA38477.1| (D10386) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 106 bits (262), Expect = 4e-22
Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 33/287 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---GDKGALP 61
V+KFGG+SV A F ++++ + + + V+SA +T+ L+ + + LP
Sbjct: 3 VLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDILP 62
Query: 62 RI---ERIHEEFLN----------YHGLNTKISISFRK-----------DMPPEALRDEI 97
+ ERI + L+ Y L + F + P+++ I
Sbjct: 63 NMSDAERIFADLLSGLAQALPGFEYDRLKGVVDQEFAQLKQVLHGVSLLGQCPDSVNAAI 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIK 157
I GE++S I G V++P+E L+A+G + ++ ++I ES R I
Sbjct: 123 ICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAA--IP 180
Query: 158 SGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+ I ++ GF GN G V GR GSDYSA LA L + C I +DV+G++T DP+ V
Sbjct: 181 ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV 240
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKTKD 262
P ARL+ +SY+E + G K LH + + P+ IP + T +
Sbjct: 241 PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSN 287
>sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
[INCLUDES: ASPARTOKINASE I ; HOMOSERINE DEHYDROGENASE I
] >gi|421254|pir||B47057 aspartate kinase (EC 2.7.2.4) I
/ homoserine dehydrogenase (EC 1.1.1.3) I - Serratia
marcescens >gi|47273|emb|CAA43212.1| (X60821) aspartate
kinase [Serratia marcescens]
Length = 819
Score = 106 bits (262), Expect = 4e-22
Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 33/287 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---GDKGALP 61
V+KFGG+SV A F ++++ + + + V+SA +T+ L+ + + LP
Sbjct: 3 VLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDILP 62
Query: 62 RI---ERIHEEFLN----------YHGLNTKISISFRK-----------DMPPEALRDEI 97
+ ERI + L+ Y L + F + P+++ I
Sbjct: 63 NMSDAERIFADLLSGLAQALPGFEYDRLKGVVDQEFAQLKQVLHGVSLLGQCPDSVNAAI 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIK 157
I GE++S I G V++P+E L+A+G + ++ ++I ES R I
Sbjct: 123 ICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAA--IP 180
Query: 158 SGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+ I ++ GF GN G V GR GSDYSA LA L + C I +DV+G++T DP+ V
Sbjct: 181 ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV 240
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKTKD 262
P ARL+ +SY+E + G K LH + + P+ IP + T +
Sbjct: 241 PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSN 287
>dbj|BAA38474.1| (D10385) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 106 bits (262), Expect = 4e-22
Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 33/287 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---GDKGALP 61
V+KFGG+SV A F ++++ + + + V+SA +T+ L+ + + LP
Sbjct: 3 VLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDILP 62
Query: 62 RI---ERIHEEFLN----------YHGLNTKISISFRK-----------DMPPEALRDEI 97
+ ERI + L+ Y L + F + P+++ I
Sbjct: 63 NMSDAERIFADLLSGLAQALPGFEYDRLKGVVDQEFAQLKQVLHGVSLLGQCPDSVNAAI 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIK 157
I GE++S I G V++P+E L+A+G + ++ ++I ES R I
Sbjct: 123 ICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAA--IP 180
Query: 158 SGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+ I ++ GF GN G V GR GSDYSA LA L + C I +DV+G++T DP+ V
Sbjct: 181 ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV 240
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKTKD 262
P ARL+ +SY+E + G K LH + + P+ IP + T +
Sbjct: 241 PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSN 287
>dbj|BAA38480.1| (D10387) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 106 bits (262), Expect = 4e-22
Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 33/287 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---GDKGALP 61
V+KFGG+SV A F ++++ + + + V+SA +T+ L+ + + LP
Sbjct: 3 VLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDILP 62
Query: 62 RI---ERIHEEFLN----------YHGLNTKISISFRK-----------DMPPEALRDEI 97
+ ERI + L+ Y L + F + P+++ I
Sbjct: 63 NMSDAERIFADLLSGLAQALPGFEYDRLKGVVDQEFAQLKQVLHGVSLLGQCPDSVNAAI 122
Query: 98 ISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIK 157
I GE++S I G V++P+E L+A+G + ++ ++I ES R I
Sbjct: 123 ICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAA--IP 180
Query: 158 SGVIPVIPGFY-GNLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+ I ++ GF GN G V GR GSDYSA LA L + C I +DV+G++T DP+ V
Sbjct: 181 ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV 240
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPIIFGKTKD 262
P ARL+ +SY+E + G K LH + + P+ IP + T +
Sbjct: 241 PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSN 287
>sp|O84367|AK_CHLTR ASPARTOKINASE (ASPARTATE KINASE) >gi|7448937|pir||G71524 probable
aspartokinase III - Chlamydia trachomatis (serotype D,
strain UW3/Cx) >gi|3328785|gb|AAC67958.1| (AE001309)
Aspartokinase III [Chlamydia trachomatis]
Length = 431
Score = 103 bits (254), Expect = 4e-21
Identities = 85/291 (29%), Positives = 144/291 (49%), Gaps = 20/291 (6%)
Query: 6 LVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTD---ELIRFANGDKGALP- 61
LV KFGG+SV A + + + + E P VVVSA+ GVTD E R G + AL
Sbjct: 9 LVCKFGGTSVGTA-QSIRRVCEIIQEERPSFVVVSAVAGVTDWLEEFCRLPKGKRAALTE 67
Query: 62 RIERIHEEFLNYHGLNTKISISFR-----KDMPPEALRDE--IISLGERISAKIFAEGLE 114
+I HE G+ ++I + +D+ D+ I+++GE +S+ +
Sbjct: 68 KIRERHESIAKELGIEVSLAIFWEILEHFEDVEELFSEDQARILAIGEDLSSTLICSYCC 127
Query: 115 LLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGF 174
+ K ++ + ++ +F A ++ + G+L ++ I ++ GF G +
Sbjct: 128 TYVLPLKRLEARQVILTDSQFLRAVPDLALMQTAWGELA--LQEDTIYLMQGFLGATSSG 185
Query: 175 RVT-FGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVA 233
+ T GRGGSD+SA+ + + +R + I +DV G+ TADPK++ +LI L++EE++
Sbjct: 186 KTTVLGRGGSDFSASLIGELCKARELRIYTDVCGVHTADPKILKDTQLIDSLTFEEMQEL 245
Query: 234 AKLGMKALHWKAVDPVV-GDIPII----FGKTKDWKFGTIVLNARSNFPII 279
A G K LH + P V +PI F TK+ + LN + P+I
Sbjct: 246 ASSGAKVLHQDMLKPCVRAKVPIFVTSTFNVTKEGTWICASLNESTEGPVI 296
>dbj|BAB08285.1| (AB007650) lysine-sensitive aspartate kinase [Arabidopsis thaliana]
Length = 544
Score = 102 bits (252), Expect = 6e-21
Identities = 84/284 (29%), Positives = 139/284 (48%), Gaps = 42/284 (14%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGA----- 59
V+KFGGSSV A +E L+ + P V+V+SA+ T++L++ G+K
Sbjct: 85 VMKFGGSSVESAERMKEVANLILSFPDERP-VIVLSAMGKTTNKLLKA--GEKAVTCGVT 141
Query: 60 -------LPRIERIHEEFLNYHGLNTKI-------------SISFRKDMPPEALRDEIIS 99
L I+ +H + G+ T + IS K++ RD ++S
Sbjct: 142 NVESIEELSFIKELHLRTAHELGVETTVIEKHLEGLHQLLKGISMMKELTLRT-RDYLVS 200
Query: 100 LGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLI--RLI 156
GE +S ++F+ L +G K++ D E I +F +A I ++ + K +
Sbjct: 201 FGECMSTRLFSAYLNKIGHKARQYDAFEIGFITTDDFTNADI-LEATYPAVSKTLVGDWS 259
Query: 157 KSGVIPVIPGFYGNLNGFR----VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTAD 212
K +PV+ G+ G G+R T GRGGSD +AT + + L R + + DV+G+ T D
Sbjct: 260 KENAVPVVTGYLGK--GWRSCAITTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCD 317
Query: 213 PKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPI 255
P + P A+ +PYL+++E A G + LH ++ P GDIP+
Sbjct: 318 PNIYPGAQSVPYLTFDEAAELAYFGAQVLHPLSMRPARDGDIPV 361
>pir||F82328 aspartokinase III, lysine-sensitive VC0391 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9654811|gb|AAF93564.1| (AE004127) aspartokinase III,
lysine-sensitive [Vibrio cholerae]
Length = 479
Score = 102 bits (251), Expect = 8e-21
Identities = 87/280 (31%), Positives = 132/280 (47%), Gaps = 27/280 (9%)
Query: 7 VVKFGGSSVRYAFEEALELVKYLSERIPI--VVVVSALKGVTDELIRFANG------DKG 58
V KFGG+SV A EA+ + E P +VV SA GVT+ L+ ANG +
Sbjct: 34 VAKFGGTSV--ANFEAMSRCSAIIENNPQTRLVVSSACSGVTNLLVELANGVASTERRQA 91
Query: 59 ALPRIERIHEEFLNYHGLNTKISISFRKDMPPEA-------------LRDEIISLGERIS 105
L ++ IH ++ T++ + + A L D +++ GE IS
Sbjct: 92 ILQQLADIHYVIIDQLADPTRVEKEVKAVLDSVASAAEAASFQSSKKLTDHLVACGELIS 151
Query: 106 AKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAG-KLIRLIKSGVIPVI 164
I + + G+ + D E L +G A ++E + A KL+ L + V+ V
Sbjct: 152 TYILTQLMRERGVDAVRFDIREVLRTDDHYGRAEPQLKEIAQLAKEKLVPLCEQYVV-VT 210
Query: 165 PGFYGN-LNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIP 223
GF G+ G T GRGGSDYSA +A + + + I +DV GI++ DP++ P A IP
Sbjct: 211 QGFIGSDAQGNTTTLGRGGSDYSAALIAEAVQASGLEIWTDVPGIYSTDPRIAPKAAPIP 270
Query: 224 YLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKTKD 262
+S+ E A G K LH + P V IP+ G +K+
Sbjct: 271 EISFSEASEMANFGAKILHPSTLLPAVRHGIPVFVGSSKE 310
>sp|P41403|AK_MYCSM ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|421602|pir||S31801 aspartate kinase (EC
2.7.2.4) alpha chain - Mycobacterium smegmatis
>gi|7434561|pir||S42422 aspartate kinase (EC 2.7.2.4)
alpha chain - Mycobacterium smegmatis
>gi|581352|emb|CAA78984.1| (Z17372) aspartokinase
[Mycobacterium smegmatis]
Length = 421
Score = 102 bits (251), Expect = 8e-21
Identities = 99/315 (31%), Positives = 150/315 (47%), Gaps = 56/315 (17%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GGSSV A E ++ ++ERI +VVVVSA+ TD+L+ A
Sbjct: 3 LVVQKYGGSSVADA-----ERIRRVAERIVETKKAGNDVVVVVSAMGDTTDDLLDLARQV 57
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
A PP D +++ GERIS + A +E L
Sbjct: 58 SPA-----------------------------PPPREMDMLLTAGERISNALVAMAIESL 88
Query: 117 GIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFR 175
G +++ + +I G G+A I G+L + G I ++ GF G +
Sbjct: 89 GAQARSFTGSQAGVITTGTHGNAKI----IDVTPGRLRDALDEGQIVLVAGFQGVSQDSK 144
Query: 176 --VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVA 233
T GRGGSD +A A+A LD+ I +DV+GIFTADP++VP+AR + +S+EE+
Sbjct: 145 DVTTLGRGGSDTTAVAVAAALDADVCEIYTDVDGIFTADPRIVPNARHLDTVSFEEMLEM 204
Query: 234 AKLGMKALHWKAVDPVVG-DIPIIFGKTKDWKFGTIVLNARSNFPI---IVHRVREDFAE 289
A G K L + V+ ++PI + K GTIV + + P+ I+ V D +E
Sbjct: 205 AACGAKVLMLRCVEYARRYNVPIHVRSSYSDKPGTIVKGSIEDIPMEDAILTGVAHDRSE 264
Query: 290 --IFVVGRNISLPGF 302
+ VVG +PG+
Sbjct: 265 AKVTVVGLP-DVPGY 278
>gb|AAB63104.1| (U62020) lysine-sensitive aspartate kinase [Arabidopsis thaliana]
Length = 544
Score = 99.8 bits (245), Expect = 4e-20
Identities = 82/282 (29%), Positives = 136/282 (48%), Gaps = 38/282 (13%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFAN---------- 54
V+KFGGSSV A +E L+ + P V+V+SA+ ++L++
Sbjct: 85 VMKFGGSSVGSAERMKEVANLIFSFPDERP-VIVLSAMGKTINKLLKAGEKAVTCGVTNV 143
Query: 55 GDKGALPRIERIHEEFLNYHGLNTKI-------------SISFRKDMPPEALRDEIISLG 101
G L I+ +H + G+ T + IS K++ RD ++S G
Sbjct: 144 GSIEELSFIKELHLRTAHELGVETTVIEKHLEGLHQLLKGISMMKELTLRT-RDYLVSFG 202
Query: 102 ERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLI--RLIKS 158
E +S ++F+ L +G K++ D E I +F +A I ++ + K + K
Sbjct: 203 ECMSTRLFSAYLNKIGHKARQYDAFEIGFITTDDFTNADI-LEATYPAVSKTLVGDWSKE 261
Query: 159 GVIPVIPGFYGNLNGFR----VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPK 214
+PV+ G+ G G+R T GRGGSD +AT + + L R + + DV+G+ T DP
Sbjct: 262 NAVPVVTGYLGK--GWRSCAITTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCDPN 319
Query: 215 LVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPI 255
+ P A+ +PYL+++E A G + LH ++ P GDIP+
Sbjct: 320 IYPGAQSVPYLTFDEAAELAYFGAQVLHPLSMRPARDGDIPV 361
>pir||D81681 aspartokinase III TC0641 [imported] - Chlamydia muridarum (strain
Nigg) >gi|7190680|gb|AAF39470.1| (AE002332)
aspartokinase III [Chlamydia muridarum]
Length = 437
Score = 99.8 bits (245), Expect = 4e-20
Identities = 76/272 (27%), Positives = 132/272 (47%), Gaps = 20/272 (7%)
Query: 6 LVVKFGGSSV--RYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALPR- 62
LV KFGG+SV + + E+++ + P VVVSA+ GVTD L F G +
Sbjct: 9 LVCKFGGTSVGTSSSIQRVCEIIR---KEKPSFVVVSAVAGVTDLLEEFCRAPVGQKSQF 65
Query: 63 ---IERIHEEFLNYHGLNTKISISFRKDMPPEAL-------RDEIISLGERISAKIFAEG 112
I HE G++ I E + +I+++GE +SA +
Sbjct: 66 TAMIREKHESIAKELGIDVAIEPFLGPLKQFEGAGHLQQEDQAKILAIGEDLSASLICSY 125
Query: 113 LELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NL 171
++ + ++ + ++ +F A ++ + G+L+ +K I ++ GF G
Sbjct: 126 CRANSLQLEQLEARQVILTDSQFLRAEPDLALMQTMWGELV--LKENTIYLMQGFLGATA 183
Query: 172 NGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIK 231
+G GRGGSD+SA+ + + ++R + I +DV G+ TADPK++ +LI +L++EE++
Sbjct: 184 SGATTVLGRGGSDFSASLVGELCEARELRIYTDVRGVHTADPKILKDTQLIDFLTFEEMQ 243
Query: 232 VAAKLGMKALHWKAVDPVV-GDIPIIFGKTKD 262
A G K LH + P + +PI T D
Sbjct: 244 ELASSGSKVLHQDMLKPCIRAKVPIFVTSTFD 275
>pir||G81537 aspartokinase III CP0803 [imported] - Chlamydophila pneumoniae
(strain AR39) >gi|7189719|gb|AAF38602.1| (AE002239)
aspartokinase III [Chlamydophila pneumoniae AR39]
Length = 440
Score = 99.5 bits (244), Expect = 5e-20
Identities = 88/270 (32%), Positives = 129/270 (47%), Gaps = 17/270 (6%)
Query: 6 LVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGD----KGALP 61
+V KFGG+S+ A E + + + P VVVSA+ GVTD L+ F + + L
Sbjct: 4 IVYKFGGTSLATA-ENICLVCDIICKDKPSFVVVSAIAGVTDLLVDFCSSSLREREEVLR 62
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMP-------PEALRDEIISLGERISAKIFAEGLE 114
+IE HEE + + +S + +P + I+SLGE ISA +
Sbjct: 63 KIEGKHEEIVKNLAIPFPVSTWTSRLLPYLQHLEISDLDFARILSLGEDISASLVRAVCS 122
Query: 115 LLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNG 173
G ++ ++ + A N+ K +L L + I I GF G N G
Sbjct: 123 TRGWDLGFLEARSVILTDDSYRSASPNLDLMKAHWHQL-ELNQPSYI--IQGFIGSNGLG 179
Query: 174 FRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVA 233
V GRGGSDYSAT +A + + V I +DV GI+T DPK++ A+ IP LS+EE++
Sbjct: 180 ETVLLGRGGSDYSATLIAELARATEVRIYTDVNGIYTMDPKVISDAQRIPELSFEEMQNL 239
Query: 234 AKLGMKALHWKAVDPVV-GDIPIIFGKTKD 262
A G K L+ + P + IPI T D
Sbjct: 240 ASFGAKVLYPPMLFPCMRAGIPIFVTSTFD 269
>sp|Q9Z6L0|AK_CHLPN ASPARTOKINASE (ASPARTATE KINASE) >gi|7434556|pir||H72002
aspartokinase III - Chlamydophila pneumoniae (strain
CWL029) >gi|4377383|gb|AAD19186.1| (AE001685)
Aspartokinase III [Chlamydophila pneumoniae CWL029]
>gi|8979422|dbj|BAA99256.1| (AP002548) aspartokinase III
[Chlamydophila pneumoniae J138]
Length = 440
Score = 99.1 bits (243), Expect = 7e-20
Identities = 93/278 (33%), Positives = 133/278 (47%), Gaps = 33/278 (11%)
Query: 6 LVVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGD----KGALP 61
+V KFGG+S+ A E + + + P VVVSA+ GVTD L+ F + + L
Sbjct: 4 IVYKFGGTSLATA-ENICLVCDIICKDKPSFVVVSAIAGVTDLLVDFCSSSLREREEVLR 62
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMP-------PEALRDEIISLGERISAKIFAEGLE 114
+IE HEE + + +S + +P + I+SLGE ISA +
Sbjct: 63 KIEGKHEEIVKNLAIPFPVSTWTSRLLPYLQHLEISDLDFARILSLGEDISASLVRAVCS 122
Query: 115 LLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIP--------VIPG 166
G L FL A+ + I +S RRA + L+K+ +I G
Sbjct: 123 TRGWD------LGFLEAR-----SVILTDDSYRRASPNLDLMKAHWHQLELNQPSYIIQG 171
Query: 167 FYG-NLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYL 225
F G N G V GRGGSDYSAT +A + + V I +DV GI+T DPK++ A+ IP L
Sbjct: 172 FIGSNGLGETVLLGRGGSDYSATLIAELARATEVRIYTDVNGIYTMDPKVISDAQRIPEL 231
Query: 226 SYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKTKD 262
S+EE++ A G K L+ + P + IPI T D
Sbjct: 232 SFEEMQNLASFGAKVLYPPMLFPCMRAGIPIFVTSTFD 269
>emb|CAC06395.1| (Y16255) aspartate kinase [Arabidopsis thaliana]
Length = 544
Score = 99.1 bits (243), Expect = 7e-20
Identities = 83/284 (29%), Positives = 138/284 (48%), Gaps = 42/284 (14%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGA----- 59
V+KFGGSSV A +E L+ + P V+V+SA+ ++L++ G+K
Sbjct: 85 VMKFGGSSVGSAERMKEVANLIFSFPDERP-VIVLSAMGKTINKLLKA--GEKAVTCGVT 141
Query: 60 -------LPRIERIHEEFLNYHGLNTKI-------------SISFRKDMPPEALRDEIIS 99
L I+ +H + G+ T + IS K++ RD ++S
Sbjct: 142 NVESIEELSFIKELHLRTAHELGVETTVIEKHLEGLHQLLKGISMMKELTLRT-RDYLVS 200
Query: 100 LGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLI--RLI 156
GE +S ++F+ L +G K++ D E I +F +A I ++ + K +
Sbjct: 201 FGECMSTRLFSAYLNKIGHKARQYDAFEIGFITTDDFTNADI-LEATYPAVSKTLVGDWS 259
Query: 157 KSGVIPVIPGFYGNLNGFR----VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTAD 212
K +PV+ G+ G G+R T GRGGSD +AT + + L R + + DV+G+ T D
Sbjct: 260 KENAVPVVTGYLGK--GWRSCAITTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCD 317
Query: 213 PKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPI 255
P + P A+ +PYL+++E A G + LH ++ P GDIP+
Sbjct: 318 PNIYPGAQSVPYLTFDEAAELAYFGAQVLHPLSMRPARDGDIPV 361
>pir||G72245 aspartokinase II - Thermotoga maritima (strain MSB8)
>gi|4982084|gb|AAD36585.1|AE001799_17 (AE001799)
aspartokinase II [Thermotoga maritima]
Length = 401
Score = 98.7 bits (242), Expect = 9e-20
Identities = 96/303 (31%), Positives = 142/303 (46%), Gaps = 56/303 (18%)
Query: 5 LLVVKFGGSSVRYAFEEALELV-----KYLSERIPIVVVVSALKGVTDELIRFANGDKGA 59
++V K+GGSSV A E ++ V K + E +VVVVSA+ TD LI+ A K
Sbjct: 3 VVVQKYGGSSV--ATPERIKNVAQRIKKKVDEGYKVVVVVSAMGKTTDNLIKLA---KEI 57
Query: 60 LPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIK 119
PR P D +++ GE++SA + + L+ LG+K
Sbjct: 58 SPR--------------------------PDSRELDMLLATGEQVSAALLSMALKDLGVK 91
Query: 120 SKVVDPLEFLIAKGEFGDA--YINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRV 176
+K ++ + I + ++I +S R +K + V+ GF G N +G
Sbjct: 92 AKSLNAFQVKIKTTPHHTSARIVDIDDSVIREN-----LKDYDVLVVTGFQGVNEHGDLT 146
Query: 177 TFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKL 236
T GRGGSD SA ALA L C I SDV+GI+T DP++ P A+ + Y++Y+E L
Sbjct: 147 TLGRGGSDTSAVALAAKLRVPCE-IYSDVDGIYTCDPRVHPRAKKLAYITYDEALELTAL 205
Query: 237 GMKALHWKAVDPVVG-DIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFVVGR 295
G K LH ++V+ IPI + + GT+V V R+ E E V G
Sbjct: 206 GAKVLHSRSVEIAKKYGIPIYCASSFTEEEGTMV----------VERLPEWLEEPVVTGA 255
Query: 296 NIS 298
IS
Sbjct: 256 TIS 258
>sp|P26512|AK_CORGL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT; ASPARTOKINASE BETA SUBUNIT]
>gi|320521|pir||S15276 aspartate kinase (EC 2.7.2.4)
alpha chain - Corynebacterium glutamicum
>gi|580983|emb|CAA40502.1| (X57226) aspartate kinase
[Corynebacterium glutamicum]
Length = 421
Score = 98.3 bits (241), Expect = 1e-19
Identities = 81/285 (28%), Positives = 137/285 (47%), Gaps = 48/285 (16%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GGSS+ E+ E ++ ++ERI +VVVVSA+ TDEL+ A
Sbjct: 3 LVVQKYGGSSL-----ESAERIRNVAERIVATKKAGNDVVVVVSAMGDTTDELLELA--- 54
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
+ +PP D +++ GERIS + A +E L
Sbjct: 55 --------------------------AAVNPVPPAREMDMLLTAGERISNALVAMAIESL 88
Query: 117 GIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFR- 175
G +++ + + E + N + G++ + G I ++ GF G R
Sbjct: 89 GAEAQSFTGSQAGVLTTE---RHGNARIVDVTPGRVREALDEGKICIVAGFQGVNKETRD 145
Query: 176 -VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAA 234
T GRGGSD +A ALA L++ I SDV+G++TADP++VP+A+ + LS+EE+ A
Sbjct: 146 VTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELA 205
Query: 235 KLGMKALHWKAVDPV-VGDIPIIFGKTKDWKFGTIVLNARSNFPI 278
+G K L ++V+ ++P+ + GT++ + + P+
Sbjct: 206 AVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPV 250
>emb|CAA67376.1| (X98873) aspartate kinase [Arabidopsis thaliana]
Length = 569
Score = 98.3 bits (241), Expect = 1e-19
Identities = 82/299 (27%), Positives = 141/299 (46%), Gaps = 35/299 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGA----- 59
V+KFGGSSV A +E +L+ E P V+V+SA+ T+ L+ G+K
Sbjct: 89 VMKFGGSSVASAERMKEVADLILTFPEESP-VIVLSAMGKTTNNLL--LAGEKAVSCGVS 145
Query: 60 -------LPRIERIHEEFLNYHGLNTKISISFRKDMPPEA------------LRDEIISL 100
L I+ +H + ++ + +++ +++ RD ++S
Sbjct: 146 NASEIEELSIIKELHIRTVKELNIDPSVILTYLEELEQLLKGIAMMKELTLRTRDYLVSF 205
Query: 101 GERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIR-LIKS 158
GE +S +IFA L +G+K++ D E I +F + I A +L +
Sbjct: 206 GECLSTRIFAAYLNTIGVKARQYDAFEIGFITTDDFTNGDILEATYPAVAKRLYDDWMHD 265
Query: 159 GVIPVIPGFYGN--LNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+P++ GF G G T GRGGSD +AT + + L + + + DV+G+ T DP +
Sbjct: 266 PAVPIVTGFLGKGWKTGAVTTLGRGGSDLTATTIGKALGLKEIQVWKDVDGVLTCDPTIY 325
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPIIFGKTKDWKF-GTIVLNAR 273
A +PYL+++E A G + LH +++ P G+IP+ + + K GTI+ R
Sbjct: 326 KRATPVPYLTFDEAAELAYFGAQVLHPQSMRPAREGEIPVRVKSSYNPKAPGTIITKTR 384
>pir||T48575 aspartate kinase - Arabidopsis thaliana >gi|7529283|emb|CAB86635.1|
(AL163491) aspartate kinase [Arabidopsis thaliana]
Length = 569
Score = 98.3 bits (241), Expect = 1e-19
Identities = 82/299 (27%), Positives = 141/299 (46%), Gaps = 35/299 (11%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGA----- 59
V+KFGGSSV A +E +L+ E P V+V+SA+ T+ L+ G+K
Sbjct: 89 VMKFGGSSVASAERMKEVADLILTFPEESP-VIVLSAMGKTTNNLL--LAGEKAVSCGVS 145
Query: 60 -------LPRIERIHEEFLNYHGLNTKISISFRKDMPPEA------------LRDEIISL 100
L I+ +H + ++ + +++ +++ RD ++S
Sbjct: 146 NASEIEELSIIKELHIRTVKELNIDPSVILTYLEELEQLLKGIAMMKELTLRTRDYLVSF 205
Query: 101 GERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIR-LIKS 158
GE +S +IFA L +G+K++ D E I +F + I A +L +
Sbjct: 206 GECLSTRIFAAYLNTIGVKARQYDAFEIGFITTDDFTNGDILEATYPAVAKRLYDDWMHD 265
Query: 159 GVIPVIPGFYGN--LNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
+P++ GF G G T GRGGSD +AT + + L + + + DV+G+ T DP +
Sbjct: 266 PAVPIVTGFLGKGWKTGAVTTLGRGGSDLTATTIGKALGLKEIQVWKDVDGVLTCDPTIY 325
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPIIFGKTKDWKF-GTIVLNAR 273
A +PYL+++E A G + LH +++ P G+IP+ + + K GTI+ R
Sbjct: 326 KRATPVPYLTFDEAAELAYFGAQVLHPQSMRPAREGEIPVRVKNSYNPKAPGTIITKTR 384
>sp|P41398|AK_CORFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT; ASPARTOKINASE BETA SUBUNIT]
>gi|289909|gb|AAA23293.1| (L16848) aspartokinase
[Corynebacterium flavescens]
Length = 421
Score = 96.3 bits (236), Expect = 5e-19
Identities = 80/285 (28%), Positives = 136/285 (47%), Gaps = 48/285 (16%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GGSS+ E+ E ++ ++ERI +VVV SA+ TDEL+ A
Sbjct: 3 LVVQKYGGSSL-----ESAERIRNVAERIVATKKAGNDVVVVCSAMGDTTDELLELA--- 54
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
+ +PP D +++ GERIS + A +E L
Sbjct: 55 --------------------------AAVNPVPPAREMDMLLTAGERISNALVAMAIESL 88
Query: 117 GIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFR- 175
G +++ + + E + N + G++ + G I ++ GF G R
Sbjct: 89 GAEAQSFTGSQAGVLTTE---RHGNARIVDVTPGRVREALDEGKICIVAGFQGVNKETRD 145
Query: 176 -VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAA 234
T GRGGSD +A ALA L++ I SDV+G++TADP++VP+A+ + LS+EE+ A
Sbjct: 146 VTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLSFEEMLELA 205
Query: 235 KLGMKALHWKAVDPV-VGDIPIIFGKTKDWKFGTIVLNARSNFPI 278
+G K L ++V+ ++P+ + GT++ + + P+
Sbjct: 206 AVGSKILVLRSVEYARAFNVPLRVRSSYSNDPGTLIAGSMEDIPV 250
>pir||G82583 bifunctional aspartokinase/homoserine dehydrogenase I XF2225
[imported] - Xylella fastidiosa (strain 9a5c)
>gi|9107374|gb|AAF85024.1|AE004035_3 (AE004035)
bifunctional aspartokinase/homoserine dehydrogenase I
[Xylella fastidiosa]
Length = 828
Score = 96.0 bits (235), Expect = 6e-19
Identities = 87/296 (29%), Positives = 135/296 (45%), Gaps = 56/296 (18%)
Query: 6 LVVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALPRI 63
+V KFGG+SV A + L+ E + V +VSA+KGVTD LI A P
Sbjct: 14 VVHKFGGTSVADADCYRHVARLLLAREETVQ-VTIVSAMKGVTDTLIALAEQAANHSPDW 72
Query: 64 ERIHEEFLNYH-----------------GLNTK--------ISISFRKDMPPEALRDEII 98
+ + ++ H LNT+ +++S + +P E L D +
Sbjct: 73 QALWQQTRTRHCDAAQALLGEHAGTLQNWLNTRFNELHEMLVALSVIRMLPSEVL-DRLQ 131
Query: 99 SLGERISAKIFAEGLELLGIKSKVVDPLEFLIAK-GEFGD-----------AYINIQESK 146
LGE SA++ + L+ G V+D + L+ GEFG A+ +Q +
Sbjct: 132 GLGEVYSAQLLGQYLQAQGEDCVVLDARQVLVVSPGEFGAEVDWATSAQHLAHWRMQHPQ 191
Query: 147 RRAGKLIRLIKSGVIPVIPGFYGN-LNGFRVTFGRGGSDYSATALARILDSRCVLIMSDV 205
RR V+ GF + G +T GR GSDYS A + ++ + I +DV
Sbjct: 192 RRV-------------VVTGFVASDRTGRAITLGRNGSDYSGAIFAALFEADELHIWTDV 238
Query: 206 EGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKT 260
+G+ +ADP++VP A + LSY+E A G K +H + + PV+ +PII T
Sbjct: 239 DGVMSADPRVVPDAVQLDALSYDEACELAYFGAKVVHPQTMSPVMKRGVPIIIRNT 294
>pir||C46665 aspartate kinase (EC 2.7.2.4) I - Bacillus subtilis
>gi|142829|gb|AAA22384.1| (L08471) aspartokinase I
[Bacillus subtilis]
Length = 404
Score = 95.2 bits (233), Expect = 1e-18
Identities = 89/301 (29%), Positives = 140/301 (45%), Gaps = 48/301 (15%)
Query: 4 KLLVVKFGGSSVRYAFEEALEL---VKYLSERIPIVVVVSAL--KG---VTDELIRFANG 55
K++V KFGG+SV+ L L + +SE +VVVVSA+ KG TD L+ G
Sbjct: 2 KIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMGRKGDPYATDSLLGLLYG 61
Query: 56 DKGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLEL 115
D+ A+ E+ D ++S GE IS+ +F L
Sbjct: 62 DQSAISPREQ-----------------------------DLLLSCGETISSVVFTSMLLD 92
Query: 116 LGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLN-GF 174
G+K+ + + A D + N + + + +L ++ + V+ GF G G
Sbjct: 93 NGVKAAALTGAQ---AGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGD 149
Query: 175 RVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAA 234
T GRGGSD SA AL +D+ + I +DVEG+ TADP++V +A+ +P ++Y EI A
Sbjct: 150 TTTIGRGGSDTSAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLA 209
Query: 235 KLGMKALHWKAVD-PVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFVV 293
G K + +AV+ + +PI T GT+V + S+ +V D E +
Sbjct: 210 YQGAKVISPRAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSS------KVGSDVFERLIT 263
Query: 294 G 294
G
Sbjct: 264 G 264
>sp|Q04795|AK1_BACSU ASPARTOKINASE 1 (ASPARTOKINASE I) (ASPARTATE KINASE 1) [CONTAINS:
ASPARTOKINASE I ALPHA SUBUNIT; ASPARTOKINASE I BETA
SUBUNIT] >gi|2634048|emb|CAB13549.1| (Z99112)
aspartokinase I (alpha and beta subunits) [Bacillus
subtilis]
Length = 404
Score = 95.2 bits (233), Expect = 1e-18
Identities = 89/301 (29%), Positives = 140/301 (45%), Gaps = 48/301 (15%)
Query: 4 KLLVVKFGGSSVRYAFEEALEL---VKYLSERIPIVVVVSAL--KG---VTDELIRFANG 55
K++V KFGG+SV+ L L + +SE +VVVVSA+ KG TD L+ G
Sbjct: 2 KIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMGRKGDPYATDSLLGLLYG 61
Query: 56 DKGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLEL 115
D+ A+ E+ D ++S GE IS+ +F L
Sbjct: 62 DQSAISPREQ-----------------------------DLLLSCGETISSVVFTSMLLD 92
Query: 116 LGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLN-GF 174
G+K+ + + A D + N + + + +L ++ + V+ GF G G
Sbjct: 93 NGVKAAALTGAQ---AGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGD 149
Query: 175 RVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAA 234
T GRGGSD SA AL +D+ + I +DVEG+ TADP++V +A+ +P ++Y EI A
Sbjct: 150 TTTIGRGGSDTSAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLA 209
Query: 235 KLGMKALHWKAVD-PVVGDIPIIFGKTKDWKFGTIVLNARSNFPIIVHRVREDFAEIFVV 293
G K + +AV+ + +PI T GT+V + S+ +V D E +
Sbjct: 210 YQGAKVISPRAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSS------KVGSDVFERLIT 263
Query: 294 G 294
G
Sbjct: 264 G 264
>gb|AAD41796.1| (AF135862) precursor monofunctional aspartokinase [Glycine max]
Length = 564
Score = 95.2 bits (233), Expect = 1e-18
Identities = 85/301 (28%), Positives = 143/301 (47%), Gaps = 39/301 (12%)
Query: 7 VVKFGGSSVRYA--FEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGA----- 59
V+KFGGSSV A +E L+ E PIVV+ SA+ T++L+ G+K
Sbjct: 87 VMKFGGSSVASADRMKEVATLILSFPEERPIVVL-SAMGKTTNKLL--LAGEKAVSCGVI 143
Query: 60 -------LPRIERIHEEFLNYHGLNTKI-------------SISFRKDMPPEALRDEIIS 99
L I+ +H ++ G++ + I+ K++ +D ++S
Sbjct: 144 NVSSIEELCFIKDLHLRTVDQLGVDGSVISKHLEELEQLLKGIAMMKELTKRT-QDYLVS 202
Query: 100 LGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIR--LI 156
GE +S +IFA L +G+K++ D E I +F +A I ++ + K + +
Sbjct: 203 FGECMSTRIFAAYLNKIGVKARQYDAFEIGFITTDDFTNADI-LEATYPAVAKRLHGDWL 261
Query: 157 KSGVIPVIPGFYGNLNGFRV--TFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPK 214
I ++ GF G T GRGGSD +AT + + L + + DV+G+ T DP
Sbjct: 262 SDPAIAIVTGFLGKARKSCAVTTLGRGGSDLTATTIGKALGLPEIQVWKDVDGVLTCDPN 321
Query: 215 LVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPIIFGKTKDWKF-GTIVLNA 272
+ P A +PYL+++E A G + LH +++ P DIP+ + + K GT++ A
Sbjct: 322 IYPKAEPVPYLTFDEAAELAYFGAQVLHPQSMRPARESDIPVRVKNSYNPKAPGTLITKA 381
Query: 273 R 273
R
Sbjct: 382 R 382
>dbj|BAA95630.1| (AB042521) aspartate kinase [Oryza sativa]
Length = 354
Score = 95.2 bits (233), Expect = 1e-18
Identities = 60/187 (32%), Positives = 101/187 (53%), Gaps = 8/187 (4%)
Query: 101 GERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIR--LIK 157
GE +S +IFA L +G+K++ D + I +FG+A I ++ + K + I+
Sbjct: 2 GECMSTRIFAAYLNKIGVKARQYDAFDIGFITTDDFGNADI-LEAAYPAVAKRLHGDWIR 60
Query: 158 SGVIPVIPGFYGN--LNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKL 215
IP++ GF G +G T GRGGSD +AT + + L R + + DV+G+ T DP +
Sbjct: 61 DPAIPIVTGFLGKGWKSGAVTTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCDPNI 120
Query: 216 VPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPIIFGKTKDWKF-GTIVLNAR 273
P+A +PYL++EE A G + LH +++ P GDIP+ + + K GT++ R
Sbjct: 121 YPNATTVPYLTFEEAAELAYFGAQVLHPQSMRPAREGDIPVRVKNSYNPKAPGTLITKQR 180
Query: 274 SNFPIIV 280
+++
Sbjct: 181 EMDKVVL 187
>sp|O25827|AK_HELPY ASPARTOKINASE (ASPARTATE KINASE) >gi|7434553|pir||E64673
aspartokinase - Helicobacter pylori (strain 26695)
>gi|2314392|gb|AAD08274.1| (AE000628) aspartokinase
(lysC) [Helicobacter pylori 26695]
Length = 405
Score = 94.8 bits (232), Expect = 1e-18
Identities = 75/253 (29%), Positives = 125/253 (48%), Gaps = 48/253 (18%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GG+S+ ++E + +++R+ +VVVVSA+ G TD L+ F
Sbjct: 2 LIVQKYGGTSMG-----SIERIHNVAQRVLESVTLGHQVVVVVSAMSGETDRLLEFGKNF 56
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
H N +++M D I+S+GE +S+ + LE
Sbjct: 57 S----------------HNPN-------KREM------DRIVSVGELVSSAALSMALERY 87
Query: 117 GIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGF 174
G ++ + E ++ F +A I ++KR + L++ I VI GF G ++ G
Sbjct: 88 GHRAISLSGKEAGILTSSHFQNAVIQSIDTKR----ITELLEKNYIVVIAGFQGADIQGE 143
Query: 175 RVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAA 234
T GRGGSD SA ALA L + I +DV+G++T DP++ A+ I +SY+E+ A
Sbjct: 144 TTTLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELA 203
Query: 235 KLGMKALHWKAVD 247
+G K L ++V+
Sbjct: 204 SMGAKVLLNRSVE 216
>sp|P53553|AK2_BACST ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTATE KINASE 2) [CONTAINS:
ASPARTOKINASE II ALPHA SUBUNIT; ASPARTOKINASE II BETA
SUBUNIT] >gi|2126845|pir||JC4640 aspartate kinase (EC
2.7.2.4) II - Bacillus stearothermophilus
>gi|928811|gb|AAB06216.1| (L46351) aspartokinase II
[Bacillus stearothermophilus]
Length = 407
Score = 94.8 bits (232), Expect = 1e-18
Identities = 84/277 (30%), Positives = 134/277 (48%), Gaps = 51/277 (18%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
++V KFGG+SV ++E +++++ R+ +VVVVSA+ TDEL+ A
Sbjct: 3 IIVQKFGGTSVG-----SIERIQHVANRVIEEVQKGNDVVVVVSAMGKTTDELVNLA--- 54
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
++ N+ P + D ++S GE++S + A L
Sbjct: 55 -----------KQISNH---------------PSKREMDMLLSTGEQVSIALLAMSLHEK 88
Query: 117 GIKSKVVDPLEFLIAKGEF-GDAYI-NIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNG 173
G K+ + + I E G+A I NI ++ R R + G I ++ GF G G
Sbjct: 89 GYKAVSLTGWQAGITTEEMHGNARIMNIDTTRIR-----RCLDEGAIVIVAGFQGVTETG 143
Query: 174 FRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVA 233
T GRGGSD +A ALA L + I +DV G+FT DP+ V +AR I +SY+E+
Sbjct: 144 EITTLGRGGSDTTAVALAAALKAEKCDIYTDVTGVFTTDPRYVKTARKIKEISYDEMLEL 203
Query: 234 AKLGMKALHWKAVDPVVG-DIPIIFGKTKDWKFGTIV 269
A LG LH +AV+ ++P+ + + + GT+V
Sbjct: 204 ANLGAGVLHPRAVEFAKNYEVPLEVRSSMENERGTMV 240
>gb|AAD49567.1|AF134837_1 (AF134837) aspartokinase subunit A [Amycolatopsis mediterranei]
Length = 421
Score = 94.8 bits (232), Expect = 1e-18
Identities = 83/287 (28%), Positives = 132/287 (45%), Gaps = 52/287 (18%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GGSS+ E+ + +K ++ERI +VVV SA+ TDEL+ A
Sbjct: 3 LVVQKYGGSSL-----ESADRIKRVAERIVATKKAGNDVVVVCSAMGDTTDELLDLAQQV 57
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
A PPE D +++ GERIS + A +
Sbjct: 58 NPA-----------------------------PPEREMDMLLTAGERISNSLVAMAIAAQ 88
Query: 117 GIKS-KVVDPLEFLIAKGEFGDA-YINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGF 174
G ++ ++ G+A I++ S+ + + G I ++ GF G
Sbjct: 89 GAEAWSFTGSQAGVVTTSVHGNARIIDVTPSR-----VTEALDQGYIALVAGFQGVAQDT 143
Query: 175 R--VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKV 232
+ T GRGGSD +A ALA L++ I SDV+G++TADP++VP A+ + ++YEE+
Sbjct: 144 KDITTLGRGGSDTTAVALAAALNADVCEIYSDVDGVYTADPRVVPDAKKLDTVTYEEMLE 203
Query: 233 AAKLGMKALHWKAVDPVVG-DIPIIFGKTKDWKFGTIVLNARSNFPI 278
A G K LH ++V+ +PI + K GT V + P+
Sbjct: 204 LAASGSKILHLRSVEYARRYGVPIRVRSSYSDKPGTTVTGSIEEIPV 250
>sp|P97151|AK_THETH ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|3088363|dbj|BAA25848.1| (AB013131)
aspartate kinase alpha subunit [Thermus thermophilus]
Length = 405
Score = 94.8 bits (232), Expect = 1e-18
Identities = 76/247 (30%), Positives = 115/247 (45%), Gaps = 38/247 (15%)
Query: 5 LLVVKFGGSSV---RYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALP 61
L+V K+GG+SV + A + Y + + VVVSA+ TDELI A K P
Sbjct: 3 LVVQKYGGTSVGDLERIHKVAQRIAHYREKGHRLAVVVSAMGHTTDELIALA---KRVNP 59
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSK 121
R PP D + + GE++S + + L +GI +K
Sbjct: 60 R--------------------------PPFRELDLLTTTGEQVSVALLSMQLWAMGIPAK 93
Query: 122 -VVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNL-NGFRVTFG 179
V + G +GDA I + ++ ++ G + VI GF G G T G
Sbjct: 94 GFVQHQIGITTDGRYGDARI----LEVNPARIREALEQGFVAVIAGFMGTTPEGEITTLG 149
Query: 180 RGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMK 239
RGGSD +A A+A L ++ I +D EG++T DP L+P AR + + Y+++ A LG +
Sbjct: 150 RGGSDTTAVAIAAALGAKECEIYTDTEGVYTTDPHLIPEARKLSVIGYDQMLEMAALGAR 209
Query: 240 ALHWKAV 246
LH +AV
Sbjct: 210 VLHPRAV 216
>gb|AAF03452.1|AC010797_28 (AC010797) putative aspartate kinase [Arabidopsis thaliana]
>gi|6513929|gb|AAF14833.1|AC011664_15 (AC011664)
putative aspartate kinase [Arabidopsis thaliana]
Length = 559
Score = 94.8 bits (232), Expect = 1e-18
Identities = 82/283 (28%), Positives = 138/283 (47%), Gaps = 40/283 (14%)
Query: 7 VVKFGGSSVRYAFE--EALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGA----- 59
V+KFGGSSV A + +L+ + P VVV+SA+ T++L+ G+K
Sbjct: 86 VMKFGGSSVASAERMIQVAKLILSFPDEKP-VVVLSAMAKTTNKLLMA--GEKAVCCGVT 142
Query: 60 -------LPRIERIHEEFLNYHGLNTKI-------------SISFRKDMPPEALRDEIIS 99
L I+ +H + G+ T + ++ K++ + RD ++S
Sbjct: 143 NVDTIEELSYIKELHIRTAHELGVETAVIAEHLEGLEQLLKGVAMMKELTLRS-RDYLVS 201
Query: 100 LGERISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIR-LIK 157
GE +S ++FA L +G K++ D E +I +F +A I + KL+ K
Sbjct: 202 FGECMSTRLFAAYLNKIGHKARQYDAFEIGIITTDDFTNADILEATYPAVSKKLLGDWSK 261
Query: 158 SGVIPVIPGFYGNLNGFR----VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADP 213
+PV+ GF G G+R T GRGGSD +AT + + L R + + DV+G+ T DP
Sbjct: 262 ENALPVVTGFLGK--GWRSCAVTTLGRGGSDLTATTIGKALGLREIQVWKDVDGVLTCDP 319
Query: 214 KLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPV-VGDIPI 255
+ A+ +P+L+++E A G + LH ++ P G+IP+
Sbjct: 320 NIYCGAQPVPHLTFDEAAELAYFGAQVLHPLSMRPAREGNIPV 362
>pir||A82311 aspartokinase, alpha and beta chains VC0547 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9654975|gb|AAF93715.1| (AE004140) aspartokinase,
alpha and beta subunits [Vibrio cholerae]
Length = 395
Score = 94.0 bits (230), Expect = 2e-18
Identities = 75/249 (30%), Positives = 121/249 (48%), Gaps = 42/249 (16%)
Query: 5 LLVVKFGGSSVRYAFEE----ALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGAL 60
L+V KFGG+SV + E A ++K ++ +VVVVSA+ G T+ L+ A
Sbjct: 5 LIVQKFGGTSVG-SIERMQTVAEHIIKAKNDGNQVVVVVSAMAGETNRLVGLAQ------ 57
Query: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALR-DEIISLGERISAKIFAEGLELLGIK 119
+ D P A D ++S GE++S + A L +G
Sbjct: 58 ------------------------QVDSVPNARELDVLLSAGEQVSMALVAMTLHKMGYA 93
Query: 120 SKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVT 177
++ + + ++ + DA I +++ + L++ I ++ GF G N NG T
Sbjct: 94 ARSLTGAQANIVTDNQHNDATIKHIDTRT----ITELLEQDFIVIVAGFQGINENGDITT 149
Query: 178 FGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLG 237
GRGGSD SA ALA L++ I +DV+GI+T DP++VPSAR + + + ++ A+ G
Sbjct: 150 LGRGGSDTSAVALAGALNADECQIFTDVDGIYTCDPRIVPSARKLDVIDFPSMEEMARKG 209
Query: 238 MKALHWKAV 246
K LH V
Sbjct: 210 AKVLHLPCV 218
>sp|P77991|AK_THEFL ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|1616997|dbj|BAA07146.1| (D37928)
aspartokinase alpha-2 [Thermus aquaticus]
Length = 405
Score = 94.0 bits (230), Expect = 2e-18
Identities = 76/247 (30%), Positives = 114/247 (45%), Gaps = 38/247 (15%)
Query: 5 LLVVKFGGSSV---RYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALP 61
L+V K+GG+SV + A + Y + + VVVSA+ TDELI A K P
Sbjct: 3 LVVQKYGGTSVGDLERIHKVAQRIAHYREKGHRLAVVVSAMGHTTDELIALA---KRVNP 59
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSK 121
R PP D + + GE++S + + L +GI +K
Sbjct: 60 R--------------------------PPFRELDLLTTTGEQVSVALLSMQLWAMGIPAK 93
Query: 122 -VVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNL-NGFRVTFG 179
V + G +GDA I + ++ + G + VI GF G G T G
Sbjct: 94 GFVQHQIGITTDGRYGDARI----LEVNPARIREALDQGFVAVIAGFMGTTPEGEITTLG 149
Query: 180 RGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMK 239
RGGSD +A A+A L ++ I +D EG++T DP L+P AR + + Y+++ A LG +
Sbjct: 150 RGGSDTTAVAIAAALGAKECEIYTDTEGVYTTDPHLIPEARKLSVIGYDQMLEMAALGAR 209
Query: 240 ALHWKAV 246
LH +AV
Sbjct: 210 VLHPRAV 216
>dbj|BAB06119.1| (AP001515) aspartokinase I (alpha and beta subunits) [Bacillus
halodurans]
Length = 411
Score = 93.2 bits (228), Expect = 4e-18
Identities = 83/271 (30%), Positives = 130/271 (47%), Gaps = 34/271 (12%)
Query: 4 KLLVVKFGGSSVRYAFEE---ALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGAL 60
K+++ KFGG+SV+ A A + K + +VVVVSA+ +GD A
Sbjct: 2 KIIIQKFGGTSVKTAEVREMAAKHVEKAVEGGYKVVVVVSAMG---------RSGDPYAT 52
Query: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKS 120
+ ++ ++TK +D+ ++S GE IS+ +F E L GI++
Sbjct: 53 DTLLQL---------VDTKTIAKREQDL--------LVSCGEIISSVVFTELLLKKGIQA 95
Query: 121 KVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNL-NGFRVTFG 179
+ + A + + N + + +L + + + V+ GF G G T G
Sbjct: 96 TAMTGAQ---AGFRTNEEFTNAKIVDMKVDRLKKTLVHQDVVVVAGFQGQSPTGETTTLG 152
Query: 180 RGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMK 239
RGGSD SATAL LD+ V I +DVEGI TADP++V AR + ++Y E+ A G K
Sbjct: 153 RGGSDTSATALGAALDAEWVDIFTDVEGIMTADPRIVSEARPLDTMTYNEVCNMAYQGAK 212
Query: 240 ALHWKAVD-PVVGDIPIIFGKTKDWKFGTIV 269
+H +AV+ + IPI T GT+V
Sbjct: 213 VIHPRAVEIAMQAKIPIHIRSTYSDGKGTLV 243
>sp|Q9ZJZ7|AK_HELPJ ASPARTOKINASE (ASPARTATE KINASE) >gi|7434552|pir||H71843
aspartokinase 2 alpha and beta chains - Helicobacter
pylori (strain J99) >gi|4155744|gb|AAD06723.1|
(AE001542) ASPARTOKINASE 2 ALPHA AND BETA SUBUNITS
[Helicobacter pylori J99]
Length = 405
Score = 92.8 bits (227), Expect = 5e-18
Identities = 77/251 (30%), Positives = 121/251 (47%), Gaps = 44/251 (17%)
Query: 5 LLVVKFGGSS------VRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKG 58
L+V K+GG+S + + LE VK + +VVVVSA+ G TD L+ F
Sbjct: 2 LIVQKYGGTSMGSIERIHNVAQRVLESVKLGHQ---VVVVVSAMSGETDRLLEFGKNFS- 57
Query: 59 ALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGI 118
H N +++M D I+S GE IS+ + LE G
Sbjct: 58 ---------------HNPN-------KREM------DRIVSAGEWISSAALSMALERYGH 89
Query: 119 KSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRV 176
++ + E ++ F +A I +++R + L++ I VI GF G ++ G
Sbjct: 90 RAISLSGKEAGILTSSHFQNAVIQSIDTQR----ITELLEKNYIVVIAGFQGADIQGETT 145
Query: 177 TFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKL 236
T GRGGSD SA ALA L + I +DV+G++T DP++ A+ I +SY+E+ A +
Sbjct: 146 TLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASM 205
Query: 237 GMKALHWKAVD 247
G K L ++V+
Sbjct: 206 GAKVLLNRSVE 216
>pir||C83531 aspartate kinase alpha and beta chain PA0904 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9946806|gb|AAG04293.1|AE004525_1 (AE004525)
aspartate kinase alpha and beta chain [Pseudomonas
aeruginosa]
Length = 412
Score = 91.7 bits (224), Expect = 1e-17
Identities = 78/249 (31%), Positives = 120/249 (47%), Gaps = 40/249 (16%)
Query: 5 LLVVKFGGSSVRYA--FEEALELVKYLSER-IPIVVVVSALKGVTDELIRFANGDKGALP 61
L+V KFGG+SV E+ E VK E +VVVVSA+ G T+ LI AN
Sbjct: 3 LIVQKFGGTSVGTVERIEQVAEKVKKFREAGDDVVVVVSAMSGETNRLIGLAN------- 55
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIK-- 119
+I E+ P D ++S GE+++ + + L G+
Sbjct: 56 ---QIMEQ-------------------PVPRELDVMVSTGEQVTIALLSMALIKRGVPAV 93
Query: 120 SKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVTF 178
S + + L ++I ++ RA +K+G + V+ GF G + NG T
Sbjct: 94 SYTGNQVRILTDSAHTKARILHIDDTHIRAD-----LKAGRVVVVAGFQGVDGNGNITTL 148
Query: 179 GRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGM 238
GRGGSD + ALA L + I +DV+G++T DP++VP AR + +++EE+ A LG
Sbjct: 149 GRGGSDTTGVALAAALKADECQIYTDVDGVYTTDPRVVPQARRLDKITFEEMLEMASLGS 208
Query: 239 KALHWKAVD 247
K L +AV+
Sbjct: 209 KVLQIRAVE 217
>gb|AAB49995.1| (U90239) aspartokinase [Mycobacterium tuberculosis]
Length = 428
Score = 91.3 bits (223), Expect = 2e-17
Identities = 91/315 (28%), Positives = 149/315 (46%), Gaps = 56/315 (17%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GGSSV A E ++ ++ERI +VVVVSA+ TD+L+ A
Sbjct: 3 LVVQKYGGSSVADA-----ERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQV 57
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
A PP D +++ GERIS + A +E L
Sbjct: 58 CPA-----------------------------PPPRELDMLLTAGERISNALVAMAIESL 88
Query: 117 GIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFR 175
G ++ + +I G G+A I G+L ++ G + ++ GF G +
Sbjct: 89 GAHARSFTGSQAGVITTGTHGNAKI----IDVTPGRLQTALEEGRVVLVAGFQGVSQDTK 144
Query: 176 --VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVA 233
T GRGGSD +A A+A L + I +DV+GIF+ADP++V +AR + +++EE+
Sbjct: 145 DVTTLGRGGSDTTAVAMAAALGADVCEIYTDVDGIFSADPRIVRNARKLDTVTFEEMLEM 204
Query: 234 AKLGMKALHWKAVDPV-VGDIPIIFGKTKDWKFGTIVLNARSNFPI---IVHRVREDFAE 289
A G K L + V+ +IP+ + + GT+V+ + + P+ I+ V D +E
Sbjct: 205 AACGAKVLMLRCVEYARRHNIPVHVRSSYSDRPGTVVVGSIKDVPMEDPILTGVAHDRSE 264
Query: 290 --IFVVGRNISLPGF 302
+ +VG +PG+
Sbjct: 265 AKVTIVGLP-DIPGY 278
>sp|P97048|AK_MYCTU ASPARTOKINASE (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA
SUBUNIT (ASK-ALPHA); ASPARTOKINASE BETA SUBUNIT
(ASK-BETA)] >gi|7434559|pir||F70794 probable ask protein
- Mycobacterium tuberculosis (strain H37RV)
>gi|2960133|emb|CAA18031.1| (AL022121) ask
[Mycobacterium tuberculosis]
Length = 421
Score = 91.3 bits (223), Expect = 2e-17
Identities = 91/315 (28%), Positives = 149/315 (46%), Gaps = 56/315 (17%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GGSSV A E ++ ++ERI +VVVVSA+ TD+L+ A
Sbjct: 3 LVVQKYGGSSVADA-----ERIRRVAERIVATKKQGNDVVVVVSAMGDTTDDLLDLAQQV 57
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
A PP D +++ GERIS + A +E L
Sbjct: 58 CPA-----------------------------PPPRELDMLLTAGERISNALVAMAIESL 88
Query: 117 GIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFR 175
G ++ + +I G G+A I G+L ++ G + ++ GF G +
Sbjct: 89 GAHARSFTGSQAGVITTGTHGNAKI----IDVTPGRLQTALEEGRVVLVAGFQGVSQDTK 144
Query: 176 --VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVA 233
T GRGGSD +A A+A L + I +DV+GIF+ADP++V +AR + +++EE+
Sbjct: 145 DVTTLGRGGSDTTAVAMAAALGADVCEIYTDVDGIFSADPRIVRNARKLDTVTFEEMLEM 204
Query: 234 AKLGMKALHWKAVDPV-VGDIPIIFGKTKDWKFGTIVLNARSNFPI---IVHRVREDFAE 289
A G K L + V+ +IP+ + + GT+V+ + + P+ I+ V D +E
Sbjct: 205 AACGAKVLMLRCVEYARRHNIPVHVRSSYSDRPGTVVVGSIKDVPMEDPILTGVAHDRSE 264
Query: 290 --IFVVGRNISLPGF 302
+ +VG +PG+
Sbjct: 265 AKVTIVGLP-DIPGY 278
>sp|Q59229|AK2_BACSP ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTATE KINASE 2) [CONTAINS:
ASPARTOKINASE II ALPHA SUBUNIT; ASPARTOKINASE II BETA
SUBUNIT] >gi|1075793|pir||A48946 aspartate kinase (EC
2.7.2.4) II precursor - Bacillus sp. (strain MGA3)
>gi|142540|gb|AAA22251.1| (M93419) aspartokinase II
[Bacillus sp.]
Length = 411
Score = 90.1 bits (220), Expect = 3e-17
Identities = 78/249 (31%), Positives = 121/249 (48%), Gaps = 40/249 (16%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERIP----IVVVVSALKGVTDELIRFANGDKGAL 60
L+V KFGG+SV + E L + + E +VVVVSA+ TDEL+ A
Sbjct: 3 LIVQKFGGTSVG-SVERILNVANRVIEEKKNGNDVVVVVSAMGKTTDELVDLAKQ----- 56
Query: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKS 120
++ H PP+ D +++ GE+++ + A L G ++
Sbjct: 57 ----------ISAH--------------PPKREMDMLLTTGEQVTISLLAMALNEKGYEA 92
Query: 121 KVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVTF 178
+ + + FG+A I E++ K+ + + G I V+ GF G + +G T
Sbjct: 93 ISYTGWQAGITTEPVFGNARILNIETE----KIQKQLNEGKIVVVAGFQGIDEHGEITTL 148
Query: 179 GRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGM 238
GRGGSD +A ALA L + I +DV G+FT DP+ V SAR + +SY+E+ A LG
Sbjct: 149 GRGGSDTTAVALAAALKAEKCDIYTDVTGVFTTDPRYVKSARKLASISYDEMLELANLGA 208
Query: 239 KALHWKAVD 247
LH +AV+
Sbjct: 209 GVLHPRAVE 217
>dbj|BAB06815.1| (AP001517) aspartokinase II alpha and beta subunits [Bacillus
halodurans]
Length = 412
Score = 89.7 bits (219), Expect = 5e-17
Identities = 76/276 (27%), Positives = 139/276 (49%), Gaps = 49/276 (17%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
++V K+GG+SV +++ +++++ RI +VVVVSA+ TDEL+
Sbjct: 3 IIVQKYGGTSVG-----SVQRIEHVANRIIATAASGKKVVVVVSAMGKTTDELV------ 51
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
GL ++I+ D P + D +++ GE+++ + A L
Sbjct: 52 ------------------GLASEIT-----DEPRKREMDMLLATGEQVTIALLAMALHKR 88
Query: 117 GIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGF 174
G ++ + + +I + G+A I ++ + R +L+ + + ++ GF G + G
Sbjct: 89 GQEATSLTGWQAGMITESHHGNARI-LEVERARMDELLDKVH---VVIVAGFQGIDQQGE 144
Query: 175 RVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAA 234
+T GRGGSD SA A+A L + I +DV G+FT DP++V AR + +SY+E+ A
Sbjct: 145 IMTLGRGGSDTSAVAIAAALKAERCEIYTDVTGVFTTDPRVVKQARKLQTISYDEMLEMA 204
Query: 235 KLGMKALHWKAVDPVVG-DIPIIFGKTKDWKFGTIV 269
LG LH +AV+ +IP++ + + GT++
Sbjct: 205 NLGASVLHPRAVEFAKNYEIPLLVASSMVDEPGTMI 240
>sp|Q9ZCI7|AK_RICPR ASPARTOKINASE (ASPARTATE KINASE) >gi|7434558|pir||E71635
aspartokinase (lysC) RP753 - Rickettsia prowazekii
>gi|3861282|emb|CAA15181.1| (AJ235273) ASPARTOKINASE
(lysC) [Rickettsia prowazekii]
Length = 446
Score = 89.3 bits (218), Expect = 6e-17
Identities = 75/252 (29%), Positives = 121/252 (47%), Gaps = 37/252 (14%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERIP----IVVVVSALKGVTDELIRFANGDKGAL 60
L++ KFGG+SV E +LV + I ++VVVSA+ GVT++L+ N
Sbjct: 3 LIIQKFGGTSVANV-ERIKKLVPIIKAEIAKNNQVIVVVSAMAGVTNQLVTLCNEVSSLN 61
Query: 61 PRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKS 120
R +F Y D +S GE ++A + A L+ IK+
Sbjct: 62 KR-----SQFAEY---------------------DVALSSGEIVTASLLALALQEEEIKA 95
Query: 121 KVVDPLEFLI-AKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVT-F 178
+ + + I + A + + L + ++ +IP+I GF G RVT
Sbjct: 96 QSLLAWQLPIRTNNNYSKALVEFITTDL----LEKYLQLKIIPIIAGFQGINKSNRVTTL 151
Query: 179 GRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGM 238
GRGGSD +A +A + + I +DV+GIFTADP+++P+A+ I + + E+ A G
Sbjct: 152 GRGGSDTTAALIAAAMKADRCDIYTDVDGIFTADPRIIPNAKRIKEIDFLEMLELASSGA 211
Query: 239 KALHWKAVDPVV 250
K LH +AV+ V+
Sbjct: 212 KVLHPRAVELVM 223
>pir||T35383 probable aspartokinase - Streptomyces coelicolor
>gi|5123890|emb|CAB45482.1| (AL079348) putative
aspartokinase [Streptomyces coelicolor A3(2)]
Length = 425
Score = 87.0 bits (212), Expect = 3e-16
Identities = 76/258 (29%), Positives = 120/258 (46%), Gaps = 57/258 (22%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GGSSV A E +K +++RI +V VVSA+ TDELI A
Sbjct: 3 LVVQKYGGSSVADA-----EGIKRVAKRIVEAKKNGNQVVAVVSAMGDTTDELIDLA--- 54
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
E++ +P D +++ GERIS + A ++ L
Sbjct: 55 -------EQV-------------------SPIPAGRELDMLLTAGERISMALLAMAIKNL 88
Query: 117 GIKSKVVDPLEFLIAKGEFGDAYINIQESKRRA-----GKLIRLIKSGVIPVIPGFYGNL 171
G +++ G + +K R G++ + G + ++ GF G
Sbjct: 89 GHEAQSFT--------GSQAGVITDSVHNKARIIDVTPGRIRTSVDEGNVAIVAGFQGVS 140
Query: 172 NGFR--VTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEE 229
+ T GRGGSD +A ALA LD+ I +DV+G+FTADP++VP A+ I ++S+E+
Sbjct: 141 QDSKDITTLGRGGSDTTAVALAAALDADVCEIYTDVDGVFTADPRVVPKAKKIDWISFED 200
Query: 230 IKVAAKLGMKALHWKAVD 247
+ A G K L + V+
Sbjct: 201 MLELAASGSKVLLHRCVE 218
>pir||H81865 aspartate kinase (EC 2.7.2.4) NMA1701 [imported] - Neisseria
meningitidis (group A strain Z2491)
>gi|7380342|emb|CAB84929.1| (AL162756) aspartate kinase
[Neisseria meningitidis Z2491]
Length = 405
Score = 87.0 bits (212), Expect = 3e-16
Identities = 75/249 (30%), Positives = 120/249 (48%), Gaps = 40/249 (16%)
Query: 5 LLVVKFGGSSV---RYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALP 61
L+V K+GG+SV A + K +E IVVVVSA+ G T+ L+ A
Sbjct: 3 LIVHKYGGTSVGSPERIKNVAKRVAKARAEGHDIVVVVSAMSGETNRLVALA-------- 54
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSK 121
HE ++ P D ++S GE+++ + A L+ +G+ +K
Sbjct: 55 -----HE----------------MQEHPDPRELDVVLSTGEQVTIGLLAMALKDIGVDAK 93
Query: 122 VVDPLEFLIAKGE-FGDAYI-NIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVTF 178
+ + A I +I + K RA + +G + ++ GF G + G T
Sbjct: 94 SYTGWQVALKTDTAHTKARIESIDDEKMRAD-----LTAGKVVIVAGFQGISSEGDISTL 148
Query: 179 GRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGM 238
GRGGSD SA ALA L + I +DV+G++T DP++VP AR + +++EE+ A LG
Sbjct: 149 GRGGSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEARRMDTVTFEEMIELASLGS 208
Query: 239 KALHWKAVD 247
K L ++V+
Sbjct: 209 KVLQIRSVE 217
>pir||E81405 aspartate kinase (EC 2.7.2.4) alpha and beta chains Cj0582
[imported] - Campylobacter jejuni (strain NCTC 11168)
>gi|6968049|emb|CAB75218.1| (AL139075) aspartokinase,
alpha and beta subunits [Campylobacter jejuni]
Length = 400
Score = 85.8 bits (209), Expect = 7e-16
Identities = 78/253 (30%), Positives = 124/253 (48%), Gaps = 48/253 (18%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERI--------PIVVVVSALKGVTDELIRFANGD 56
L+V K+GG+SV LE ++ ++ R+ +VVVVSA+ GVT+ LI A
Sbjct: 2 LIVQKYGGTSVG-----TLERIEAVANRVIQSAQQGNQLVVVVSAMSGVTNTLIEQA--- 53
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
E+ + KDM D ++S GER+++ + + L
Sbjct: 54 ------------EYFS--------KTPNGKDM------DMLLSSGERVTSALLSIALNEK 87
Query: 117 GIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGF 174
G + + +I F A I+ ++K +L ++G I VI GF G + G
Sbjct: 88 GCPAISFSGRKAGIITDSVFTKARIHHIDTKAIKSEL----QNGKIVVIAGFQGVDEEGN 143
Query: 175 RVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAA 234
T GRGGSD SA A+A L++ I +DV+G++T DP++ P A+ + +SYEE+ A
Sbjct: 144 VTTLGRGGSDLSAVAVAGALNADLCEIYTDVDGVYTTDPRIEPKAKKLDKISYEEMLELA 203
Query: 235 KLGMKALHWKAVD 247
LG K L ++V+
Sbjct: 204 SLGAKVLQNRSVE 216
>pir||T39822 aspartate kinase - fission yeast (Schizosaccharomyces pombe)
>gi|3080523|emb|CAA18652.1| (AL022599) aspartate kinase
[Schizosaccharomyces pombe]
Length = 519
Score = 85.8 bits (209), Expect = 7e-16
Identities = 83/292 (28%), Positives = 141/292 (47%), Gaps = 48/292 (16%)
Query: 6 LVVKFGGSSV-RYAFEEALELVK-YLSERIPIVVVVSA------LKGVTDELIRFANGDK 57
+V KFGG+SV ++ + A+++ K YLS + + +V SA +G T LIR +
Sbjct: 16 VVQKFGGTSVGKFPIKIAVDVAKEYLSTK-RVALVCSARSTDTKAEGTTTRLIRAT--EA 72
Query: 58 GALPRIERIHE--------------EFLNYHGLNTKISISFRKD---------------- 87
P + +H+ +F+ G+ ++ +F D
Sbjct: 73 ALRPAVGSVHDLVRIIETDHVQAARDFIQDVGIQDELIDAFHADCVELEQYLNAIRVLSE 132
Query: 88 MPPEALRDEIISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFG--DAYINIQES 145
+ P RD +I +GER+S + A L+ GI S+ +D + + E+ DA +
Sbjct: 133 VSPRT-RDLVIGMGERLSCRFMAAVLKDQGIDSEFIDMSHIIDEQREWRNLDASFYAYLA 191
Query: 146 KRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVT-FGRGGSDYSATALARILDSRCVLIMSD 204
+ A K+ + +PV+ GF+G + G ++ GRG +D+ A LA L++ + I +
Sbjct: 192 SQLASKVTAV--GNKVPVVTGFFGMVPGGLLSQIGRGYTDFCAALLAVGLNADELQIWKE 249
Query: 205 VEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPI 255
V+GIFTADP+ VP+ARL+P ++ EE G + +H + VV IPI
Sbjct: 250 VDGIFTADPRKVPTARLLPLITPEEAAELTYYGSEVIHPFTMSQVVHARIPI 301
>pir||F81076 aspartokinase, alpha and beta chains NMB1498 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226740|gb|AAF41854.1| (AE002499) aspartokinase,
alpha and beta subunits [Neisseria meningitidis MC58]
Length = 405
Score = 85.8 bits (209), Expect = 7e-16
Identities = 74/249 (29%), Positives = 120/249 (47%), Gaps = 40/249 (16%)
Query: 5 LLVVKFGGSSV---RYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALP 61
L+V K+GG+SV A + K +E IVVVVSA+ G T+ L+ A
Sbjct: 3 LIVHKYGGTSVGSPERIKNVAKRVAKARAEGHDIVVVVSAMSGETNRLVALA-------- 54
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSK 121
HE ++ P D +++ GE+++ + A L+ +G+ +K
Sbjct: 55 -----HE----------------MQEHPDPRELDVVLATGEQVTIGLLAMALKDIGVDAK 93
Query: 122 VVDPLEFLIAKGE-FGDAYI-NIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVTF 178
+ + A I +I + K RA + +G + ++ GF G + G T
Sbjct: 94 SYTGWQVALKTDTAHTKARIESIDDEKMRAD-----LTAGKVVIVAGFQGISSEGDISTL 148
Query: 179 GRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGM 238
GRGGSD SA ALA L + I +DV+G++T DP++VP AR + +++EE+ A LG
Sbjct: 149 GRGGSDTSAVALAAALKADECQIYTDVDGVYTTDPRVVPEARRMDTVTFEEMIELASLGS 208
Query: 239 KALHWKAVD 247
K L ++V+
Sbjct: 209 KVLQIRSVE 217
>dbj|BAB05219.1| (AP001512) homoserine dehydrogenase [Bacillus halodurans]
Length = 456
Score = 85.4 bits (208), Expect = 9e-16
Identities = 91/315 (28%), Positives = 144/315 (44%), Gaps = 34/315 (10%)
Query: 7 VVKFGGSSVRYAFEEALELVKYLSERIPIVVVVSALKG--------VTDELIRFANG--D 56
V KFGG+SV A E+ ++ +++ + +VV + G VTD LIR +
Sbjct: 3 VTKFGGTSVASA-EQIRKVATIVADDVERKIVVVSAPGKRHSSDTKVTDLLIRLGETYLE 61
Query: 57 KG----ALPRIERIHEEFLNYHGLNTKISISFRKDMP---------PEALRDEIISLGER 103
KG L + R +EE L +I D+ P A D++ + GE
Sbjct: 62 KGYANEELEAVLRRYEEIAKGLELGQEIIDQIANDLHTRLTFNQSNPGAFMDQLKASGED 121
Query: 104 ISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIP 162
+AK+ A L+ G+ + V P E L+ E G+A Q L +L + +
Sbjct: 122 NNAKLIAAYLQTKGMNAVYVSPKEAGLLVSDEPGNA----QVLPEAYDHLKKLRERDEMI 177
Query: 163 VIPGFYG-NLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARL 221
V PGF+G + +G VTF RGGSD + LA + + +DV+ +F A+P +V S
Sbjct: 178 VFPGFFGFSPDGALVTFPRGGSDITGAILAAGVKAELYENFTDVDSVFAANPNVVESPAQ 237
Query: 222 IPYLSYEEIKVAAKLGMKALHWKAVDPVVGD-IPIIFGKTKDWKF-GTIVLNARSNF--P 277
I ++Y E++ + G H +A+ P IP+ T + GT++L R F P
Sbjct: 238 IRRMTYREMRELSYAGFSVFHDEALIPAFRQKIPVCVKNTNNPSSPGTMILAEREYFLNP 297
Query: 278 IIVHRVREDFAEIFV 292
+I + FA I+V
Sbjct: 298 VIGIAADKGFATIYV 312
>emb|CAA99580.1| (Z75208) aspartokinase II alpha subunit [Bacillus subtilis]
>gi|2635312|emb|CAB14807.1| (Z99118) aspartokinase II
alpha subunit (aa 1->408) and beta subunit (aa 246->408)
[Bacillus subtilis]
Length = 408
Score = 82.3 bits (200), Expect = 8e-15
Identities = 77/271 (28%), Positives = 127/271 (46%), Gaps = 39/271 (14%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERIP---IVVVVSALKGVTDELIRFANGDKGALP 61
L+V KFGG+SV + + ++E+ +VVVVSA+ TDEL+ A
Sbjct: 3 LIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGKSTDELVSLAK------- 55
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSK 121
+IS D P + D +++ GE+++ + + L+ G +
Sbjct: 56 -------------------AIS---DQPSKREMDMLLATGEQVTISLLSMALQEKGYDAV 93
Query: 122 VVDPLEFLI-AKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVT-FG 179
+ I + G+A I ++ A +L + G I ++ GF G +T G
Sbjct: 94 SYTGWQAGIRTEAIHGNARITDIDTSVLADQL----EKGKIVIVAGFQGMTEDCEITTLG 149
Query: 180 RGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMK 239
RGGSD +A ALA L + I +DV G+FT DP+ V SAR + +SY+E+ A LG
Sbjct: 150 RGGSDTTAVALAAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAG 209
Query: 240 ALHWKAVDPVVG-DIPIIFGKTKDWKFGTIV 269
LH +AV+ +P+ + + + GT++
Sbjct: 210 VLHPRAVEFAKNYQVPLEVRSSTETEAGTLI 240
>sp|P08495|AK2_BACSU ASPARTOKINASE 2 (ASPARTOKINASE II) (ASPARTATE KINASE 2) [CONTAINS:
ASPARTOKINASE II ALPHA SUBUNIT; ASPARTOKINASE II BETA
SUBUNIT] >gi|80248|pir||A29314 aspartate kinase (EC
2.7.2.4) II precursor - Bacillus subtilis
>gi|142523|gb|AAA87318.1| (J03294) aspartokinase II
alpha subunit [Bacillus subtilis]
Length = 408
Score = 81.1 bits (197), Expect = 2e-14
Identities = 77/271 (28%), Positives = 126/271 (46%), Gaps = 39/271 (14%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERIP---IVVVVSALKGVTDELIRFANGDKGALP 61
L+V KFGG+SV + + ++E+ +VVVVSA+ TDEL+ A
Sbjct: 3 LIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGKSTDELVSLAK------- 55
Query: 62 RIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSK 121
+IS D P + D +++ GE+++ + + L+ G +
Sbjct: 56 -------------------AIS---DQPSKREMDMLLATGEQVTISLLSMALQEKGYDAV 93
Query: 122 VVDPLEFLI-AKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVT-FG 179
+ I + G+A I ++ A +L + G I ++ GF G +T G
Sbjct: 94 SYTGWQAGIRTEAIHGNARITDIDTSVLADQL----EKGKIVIVAGFQGMTEDCEITTLG 149
Query: 180 RGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMK 239
RGGSD +A ALA L I +DV G+FT DP+ V SAR + +SY+E+ A LG
Sbjct: 150 RGGSDTTAVALAAALKVDKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAG 209
Query: 240 ALHWKAVDPVVG-DIPIIFGKTKDWKFGTIV 269
LH +AV+ +P+ + + + GT++
Sbjct: 210 VLHPRAVEFAKNYQVPLEVRSSTETEAGTLI 240
>emb|CAC11508.1| (AL445064) aspartate kinase related protein [Thermoplasma
acidophilum]
Length = 272
Score = 80.4 bits (195), Expect = 3e-14
Identities = 71/248 (28%), Positives = 123/248 (48%), Gaps = 17/248 (6%)
Query: 7 VVKFGGSSVR--YAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALPRIE 64
V+K GGS ++ + ++++ + R PI+VV SA G+TD L RF D+ R++
Sbjct: 6 VIKIGGSVLKDGSSLPRVMDIISHF--RSPILVV-SAFGGITDALYRFYEYDES---RMD 59
Query: 65 RIHEEFLNYHGLNTKISISFRKDMPPEAL----RDEIISLGERISAKIFAEGLELLGIKS 120
++ + L + G+ K +I ++ + +D +S GE++SA A L GI +
Sbjct: 60 KLRDLLLMHLGILWKYNIEAHPEISIQDSSILDQDAYVSYGEKMSAFTLARFLTGNGIPA 119
Query: 121 KVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVTF 178
+ E LI + + ++++ S+ + R+ SG +PV+ GF+G + G
Sbjct: 120 APIYTDEAGLIVEEISKERTVDLEGSRAFFENIARVETSGKVPVVTGFFGIDRYGKTRIL 179
Query: 179 GRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGM 238
GR SDYSA A+A IL R V+++ DV GI+ L ++ + YE G
Sbjct: 180 GRNSSDYSAVAVAAILGIREVILIKDVPGIYM---NLEDRTSIVNRIDYETALRIVDRGS 236
Query: 239 KALHWKAV 246
K +H A+
Sbjct: 237 KVVHRAAL 244
>pir||H72364 aspartokinase II - Thermotoga maritima (strain MSB8)
>gi|4981061|gb|AAD35632.1|AE001729_12 (AE001729)
aspartokinase II [Thermotoga maritima]
Length = 739
Score = 80.0 bits (194), Expect = 4e-14
Identities = 72/250 (28%), Positives = 113/250 (44%), Gaps = 38/250 (15%)
Query: 3 YKLLVVKFGG---SSVRYAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGA 59
+ ++V+KFGG S V + A +++K + VVV+SA+ TD LI A
Sbjct: 338 FSVVVMKFGGAAISDVEKLEKVAEKIIKRKKSGVKPVVVLSAMGDTTDHLIELAK----- 392
Query: 60 LPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIK 119
+ ++ P L D ++S GE S + + L G K
Sbjct: 393 -----------------------TIDENPDPREL-DLLLSTGEIQSVALMSIALRKRGYK 428
Query: 120 SKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVT 177
+ + +I +G A I + R +K IPV+ GF G G T
Sbjct: 429 AISFTGNQLKIITDKRYGSARI----IDINTDIISRYLKQDFIPVVAGFQGITETGDITT 484
Query: 178 FGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLG 237
GRGGSD +A ALA L + + DV+G++TADP++V AR+I LS+EE+ ++ G
Sbjct: 485 LGRGGSDLTAIALAYSLGADLCELYKDVDGVYTADPRIVKDARVIKELSWEEMIELSRHG 544
Query: 238 MKALHWKAVD 247
+ L +A +
Sbjct: 545 AQVLQARAAE 554
>gb|AAG20470.1| (AE005119) aspartokinase II alpha subunit; LysC [Halobacterium sp.
NRC-1]
Length = 353
Score = 79.2 bits (192), Expect = 7e-14
Identities = 56/155 (36%), Positives = 83/155 (53%), Gaps = 13/155 (8%)
Query: 82 ISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSKVVDP--LEFLIAKGEFG--D 137
I+F D P A EI+S+GER S ++ L G+ + ++P ++ I E G D
Sbjct: 12 ITFDADEPDRA---EIVSMGERTSVRMLKAALAARGVDATFLEPGTTDWPIVTNERGEVD 68
Query: 138 AYINIQESKRRAGKLIRLIKSGVIPVIPGFYG-NLNGFRVTFGRGGSDYSATALARILDS 196
A R AG+L +PVI GF + G T GRGGSD +A L R LD+
Sbjct: 69 ADATAAGVDRLAGRL-----GDTVPVITGFLAEDPQGNVTTLGRGGSDTTAVMLGRYLDA 123
Query: 197 RCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIK 231
V+I++DVEGI T DP++V AR + ++ +E++
Sbjct: 124 DEVVIVTDVEGIMTGDPQVVEGARNVGRITVDELR 158
>pir||S76764 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1653765|dbj|BAA18676.1| (D90916) aspartate kinase
[Synechocystis sp.]
Length = 600
Score = 78.8 bits (191), Expect = 9e-14
Identities = 75/255 (29%), Positives = 122/255 (47%), Gaps = 50/255 (19%)
Query: 5 LLVVKFGGSSVRYAFEEALELVKYLSERIP--------IVVVVSALKGVTDELIRFANGD 56
L+V KFGG+SV +E ++ +++RI +VVVVSA+ TD L+ A
Sbjct: 3 LIVQKFGGTSVG-----TVERIQAVAQRIKRTVQGGNSLVVVVSAMGKSTDVLVDLAQ-- 55
Query: 57 KGALPRIERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELL 116
+IS + P D ++S GE++S + + L+ +
Sbjct: 56 ----------------------QISPN-----PCRREMDMLLSTGEQVSIALLSLALQEI 88
Query: 117 GIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYG--NLNG 173
+ + + ++ + E A I + R +L ++ G + V+ GF G ++
Sbjct: 89 DQPAISLTGAQVGIVTEAEHSRARI----LEIRPDRLEHHLREGKVVVVAGFQGISSVEH 144
Query: 174 FRVT-FGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKV 232
+T GRGGSD SA ALA L + I +DV GI T DP+LVP A+L+ ++ +E+
Sbjct: 145 LEITTLGRGGSDTSAVALAAALKADFCEIYTDVPGILTTDPRLVPEAQLMAEITCDEMLE 204
Query: 233 AAKLGMKALHWKAVD 247
A LG K LH +AV+
Sbjct: 205 LASLGAKVLHPRAVE 219
>pir||B82045 aspartokinase II/homoserine dehydrogenase, methionine-sensitive
VC2684 [imported] - Vibrio cholerae (group O1 strain
N16961) >gi|9657279|gb|AAF95825.1| (AE004334)
aspartokinase II/homoserine dehydrogenase,
methionine-sensitive [Vibrio cholerae]
Length = 803
Score = 77.3 bits (187), Expect = 3e-13
Identities = 82/272 (30%), Positives = 121/272 (44%), Gaps = 43/272 (15%)
Query: 9 KFGGSSVR--YAFEEALELVKYLSERIPIVVVVSALKGVTDELIRFANGDKGALPRIERI 66
KFGGSS+ ++ +++K S+ +VVV +A K T+ LI F AL + R+
Sbjct: 9 KFGGSSLADPECYQRVAKILKSYSKSDDLVVVSAAGK-TTNRLISFVE----ALSKDGRV 63
Query: 67 HEEFLNYHGLNTKISISFRKDMPPEA-------LRDEIISLGERI--------------- 104
E L H L S K + EA L+ EI LGE
Sbjct: 64 AHETL--HALRQYQSELITKLLSNEAAEPLLSQLQQEISVLGELTAPLSNAQYAWVLGHG 121
Query: 105 ---SAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYINIQESKRRAGKLIRLIKSGVI 161
SA++ A L + + D FL A +A + + R+ L++ + +
Sbjct: 122 ELWSARLLAALLNQQDLPAVAQDARTFLRA-----EAGTQPEVDRARSYPLLKAVLAQHT 176
Query: 162 P---VIPGFYG-NLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVP 217
VI GF N G V GR GSDYSAT + + + V I SDV G+++ADP++V
Sbjct: 177 QRRVVITGFMAQNEQGDTVLLGRNGSDYSATVIGALAEVSRVTIWSDVAGVYSADPRIVS 236
Query: 218 SARLIPYLSYEEIKVAAKLGMKALHWKAVDPV 249
A L+P L +E A+L LH + + PV
Sbjct: 237 DACLLPLLRLDEANELARLAAPVLHSRTLQPV 268
>sp|P94417|AK3_BACSU PROBABLE ASPARTOKINASE (ASPARTATE KINASE) >gi|7474867|pir||A69763
homoserine dehydrogenase homolog yclM - Bacillus
subtilis >gi|1805449|dbj|BAA09011.1| (D50453) homologue
of aspartokinase 2 alpha and beta subunits LysC of B.
subtilis [Bacillus subtilis] >gi|2632680|emb|CAB12187.1|
(Z99106) similar to homoserine dehydrogenase [Bacillus
subtilis]
Length = 454
Score = 75.3 bits (182), Expect = 1e-12
Identities = 103/380 (27%), Positives = 171/380 (44%), Gaps = 55/380 (14%)
Query: 7 VVKFGGSSVRYAFEEALELVKYLSERIPI--VVVVSAL-------KGVTDELIRFANG-- 55
VVKFGGSS+ A L+ V ++ P VVVSA VTD LI A
Sbjct: 3 VVKFGGSSL--ASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAEDTKVTDLLIACAEQYL 60
Query: 56 DKGALPRI-ERIHEEFL---NYHGLNTKISISFRKDM---------PPEALRDEIISLGE 102
G+ P + E + E + N L I R D+ PE D + + GE
Sbjct: 61 ATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLEGDKSNPEQYLDAVKASGE 120
Query: 103 RISAKIFAEGLELLGIKSKVVDPLEF-LIAKGEFGDAYINIQESKRRAGKLIRLIKSGVI 161
+AK+ A G+K++ V+P + L E G+A + + ES + L RL + +
Sbjct: 121 DNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQV-LPESYQN---LYRLRERDGL 176
Query: 162 PVIPGFYG-NLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSAR 220
+ PGF+G + +G +TF R GSD + + LA L + +DV+ +++ +P V + +
Sbjct: 177 IIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENFTDVDAVYSVNPSFVENPK 236
Query: 221 LIPYLSYEEIKVAAKLGMKALHWKAVDPVV-GDIPIIFGKTKDWKF-GTIVLNAR--SNF 276
I L+Y E++ + G H +A+ P IP+ T + GT V++ R +N
Sbjct: 237 EISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKNTNNPSAEGTRVVSKRDNTNG 296
Query: 277 PIIVHRVREDFAEIFV----VGRNISLPGF------LVEEEREDFVKIVVAREDLPEAIR 326
P++ F I++ + R I GF ++EE + + +D+ +R
Sbjct: 297 PVVGIASDTGFCSIYISKYLMNREI---GFGRRALQILEEHGLTYEHVPSGIDDMTIILR 353
Query: 327 E------IHREVVEREEKNL 340
+ R V++R E++L
Sbjct: 354 QGQMDAATERSVIKRIEEDL 373
>pir||T04752 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
1.1.1.3) T16H5.70 - Arabidopsis thaliana
>gi|3250680|emb|CAA19688.1| (AL024486) aspartate
kinase-homoserine dehydrogenase-like protein
[Arabidopsis thaliana] >gi|7268767|emb|CAB78973.1|
(AL161551) aspartate kinase-homoserine
dehydrogenase-like protein [Arabidopsis thaliana]
Length = 916
Score = 74.5 bits (180), Expect = 2e-12
Identities = 80/281 (28%), Positives = 130/281 (45%), Gaps = 34/281 (12%)
Query: 7 VVKFGGSSV---RYAFEEALELVKYLSERIPIVVVVSALKGVTD---ELIRFANG-DKGA 59
V KFGG+ V + A ++ SER +VVVSA+ VTD +LIR A D
Sbjct: 91 VHKFGGTCVGNSQRIRNVAEVIINDNSERK--LVVVSAMSKVTDMMYDLIRKAQSRDDSY 148
Query: 60 LPRIERIHEE----------------FLNY-----HGLNTKISISFRKDMPPEALRDEII 98
L +E + E+ FL++ L + + E+ D +
Sbjct: 149 LSALEAVLEKHRLTARDLLDGDDLASFLSHLHNDISNLKAMLRAIYIAGHASESFSDFVA 208
Query: 99 SLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKGEFGDAYI-NIQESKRRAGKLIRLIK 157
GE SA++ + + G++ K +D + LI + + ES++R K L
Sbjct: 209 GHGELWSAQMLSYVVRKTGLECKWMDTRDVLIVNPTSSNQVDPDFGESEKRLDKWFSLNP 268
Query: 158 SGVIPVIPGFYGNL-NGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLV 216
S +I + GF + T R GSD+SA + +L +R V I +DV+G+++ADP+ V
Sbjct: 269 SKII-IATGFIASTPQNIPTTLKRDGSDFSAAIMGALLRARQVTIWTDVDGVYSADPRKV 327
Query: 217 PSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG-DIPII 256
A ++ LSY+E + G LH + + PV+ +IPI+
Sbjct: 328 NEAVILQTLSYQEAWEMSYFGANVLHPRTIIPVMRYNIPIV 368
>sp|P00562|AK2H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE II (AKII-HDII)
[INCLUDES: ASPARTOKINASE II ; HOMOSERINE DEHYDROGENASE
II ] >gi|2144429|pir||DEECK2 metL bifunctional enzyme -
Escherichia coli >gi|305043|gb|AAB03072.1| (L19201)
aspartokinase II/homoserine dehydrogenase II
[Escherichia coli] >gi|1790376|gb|AAC76922.1| (AE000468)
aspartokinase II and homoserine dehydrogenase II
[Escherichia coli K12]
Length = 810
Score = 73.4 bits (177), Expect = 4e-12
Identities = 55/169 (32%), Positives = 84/169 (49%), Gaps = 17/169 (10%)
Query: 91 EALRDEIISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKG------EFGDAYINIQE 144
+A+ E++ GE SA++ + L G+ + +D EFL A+ + G +Y +Q+
Sbjct: 119 DAVYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQ 178
Query: 145 SK-RRAGKLIRLIKSGVIPVIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIM 202
+ GK + V+ GF N G V GR GSDYSAT + + V I
Sbjct: 179 LLVQHPGKRL---------VVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIW 229
Query: 203 SDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG 251
SDV G+++ADP+ V A L+P L +E A+L LH + + PV G
Sbjct: 230 SDVAGVYSADPRKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSG 278
>emb|CAA23585.1| (V00305) aspartokinase II-homoserine dehydrogenase II [Escherichia
coli]
Length = 809
Score = 73.4 bits (177), Expect = 4e-12
Identities = 55/169 (32%), Positives = 84/169 (49%), Gaps = 17/169 (10%)
Query: 91 EALRDEIISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKG------EFGDAYINIQE 144
+A+ E++ GE SA++ + L G+ + +D EFL A+ + G +Y +Q+
Sbjct: 118 DAVYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQ 177
Query: 145 SK-RRAGKLIRLIKSGVIPVIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIM 202
+ GK + V+ GF N G V GR GSDYSAT + + V I
Sbjct: 178 LLVQHPGKRL---------VVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIW 228
Query: 203 SDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG 251
SDV G+++ADP+ V A L+P L +E A+L LH + + PV G
Sbjct: 229 SDVAGVYSADPRKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSG 277
>gb|AAA24165.1| (J01651) aspartokinase II-homoserine dehydrogenase II [Escherichia
coli]
Length = 810
Score = 71.8 bits (173), Expect = 1e-11
Identities = 55/169 (32%), Positives = 83/169 (48%), Gaps = 17/169 (10%)
Query: 91 EALRDEIISLGERISAKIFAEGLELLGIKSKVVDPLEFLIAKG------EFGDAYINIQE 144
+A+ E++ GE SA++ + L G+ + +D EFL A+ + G +Y +Q+
Sbjct: 119 DAVYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQ 178
Query: 145 SK-RRAGKLIRLIKSGVIPVIPGFYGNLN-GFRVTFGRGGSDYSATALARILDSRCVLIM 202
+ GK + V+ GF N G V GR GSDYSAT + + V I
Sbjct: 179 LLVQHPGKRL---------VVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIW 229
Query: 203 SDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVDPVVG 251
SDV G+++ADP V A L+P L +E A+L LH + + PV G
Sbjct: 230 SDVAGVYSADPGKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSG 278
>emb|CAB57346.1| (Y15939) aspartokinase [Dichelobacter nodosus]
Length = 206
Score = 71.0 bits (171), Expect = 2e-11
Identities = 37/99 (37%), Positives = 60/99 (60%), Gaps = 1/99 (1%)
Query: 150 GKLIRLIKSGVIPVIPGFYG-NLNGFRVTFGRGGSDYSATALARILDSRCVLIMSDVEGI 208
G + R + +G + ++ GF G + G T GRGGSD +A ALA +L + I +DV+G+
Sbjct: 7 GAIYRALSAGKVVIVAGFQGVDEAGDITTLGRGGSDTTAVALAAVLKADECQIYTDVDGV 66
Query: 209 FTADPKLVPSARLIPYLSYEEIKVAAKLGMKALHWKAVD 247
+T DP++ P AR + +S+ E+ A LG K L ++V+
Sbjct: 67 YTTDPRIEPRARKLEQISFVEMLEMASLGSKVLQIRSVE 105
>pir||T03589 probable aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
(EC 1.1.1.3) precursor - rice
>gi|1777375|dbj|BAA11417.1| (D78573) aspartate
kinase-homoserine dehydrogenase [Oryza sativa]
Length = 915
Score = 70.2 bits (169), Expect = 3e-11
Identities = 51/196 (26%), Positives = 93/196 (47%), Gaps = 5/196 (2%)
Query: 63 IERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSKV 122
+ ++H + N + I I+ E+ D ++ GE SA++ + ++ G+
Sbjct: 176 LAQLHSDISNLRAMLRAIFIAGHAT---ESFSDFVVGHGELWSAQMLSYAIKKSGVPCSW 232
Query: 123 VDPLEFLIAKGEFGDAYI-NIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNGFRVTFGRG 181
+D E L+ K + + ES++R K + +I T R
Sbjct: 233 MDTREVLVVKPSGSNQVDPDYLESEKRLQKWFSRQPAEIIIATGFIASTAENIPTTLKRD 292
Query: 182 GSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLGMKAL 241
GSD+SA+ + ++ + V I +DV+G+F+ADP+ V A ++ LSY+E + G L
Sbjct: 293 GSDFSASIIGSLVRACQVTIWTDVDGVFSADPRKVSEAVILSTLSYQEAWEMSYFGANVL 352
Query: 242 HWKAVDPVVGD-IPII 256
H + + PV+ D IPI+
Sbjct: 353 HPRTIIPVMKDNIPIV 368
>sp|P49080|AKH2_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE 2, CHLOROPLAST
PRECURSOR (AK-HD 2) (AK-HSDH 2) [INCLUDES: ASPARTOKINASE
; HOMOSERINE DEHYDROGENASE ] >gi|7434567|pir||T02954
aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
(EC 1.1.1.3) precursor - maize >gi|500853|gb|AAA74361.1|
(L33913) aspartate kinase-homoserine dehydrogenase [Zea
mays]
Length = 917
Score = 68.7 bits (165), Expect = 1e-10
Identities = 55/200 (27%), Positives = 96/200 (47%), Gaps = 13/200 (6%)
Query: 63 IERIHEEFLNYHGLNTKISISFRKDMPPEALRDEIISLGERISAKIFAEGLELLGIKSKV 122
+ ++H + N + I I+ E+ D ++ GE SA++ + ++ G
Sbjct: 178 LSQLHSDVSNLRAMLRAIYIAGHAT---ESFSDFVVGHGELWSAQMLSYAIKKSGAPCSW 234
Query: 123 VDPLEFLIAK----GEFGDAYINIQESKRRAGKLIRLIKSGVIPVIPGFYGNLNG-FRVT 177
+D E L+ + Y+ E ++R K + +I V GF + G T
Sbjct: 235 MDTREVLVVTPSGCNQVDPDYL---ECEKRLQKWFSRQPAEII-VATGFIASTAGNIPTT 290
Query: 178 FGRGGSDYSATALARILDSRCVLIMSDVEGIFTADPKLVPSARLIPYLSYEEIKVAAKLG 237
R GSD+SA + ++ +R V I +DV+G+F+ADP+ V A ++ LSY+E + G
Sbjct: 291 LKRDGSDFSAAIVGSLVRARQVTIWTDVDGVFSADPRKVSEAVILSTLSYQEAWEMSYFG 350
Query: 238 MKALHWKAVDPVVGD-IPII 256
LH + + PV+ D IPI+
Sbjct: 351 ANVLHPRTIIPVMKDNIPIV 370
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.322 0.143 0.406
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 128105882
Number of Sequences: 2977
Number of extensions: 5362274
Number of successful extensions: 12564
Number of sequences better than 1.0e-10: 78
Number of HSP's better than 0.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 60
Number of HSP's that attempted gapping in prelim test: 12416
Number of HSP's gapped (non-prelim): 107
length of query: 352
length of database: 189,106,746
effective HSP length: 55
effective length of query: 297
effective length of database: 156,189,961
effective search space: 46388418417
effective search space used: 46388418417
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.9 bits)
S2: 165 (68.7 bits)