BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1676 (thrB-1) DE:HOMOSERINE KINASE (EC 2.7.1.39) (HK).
(294 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||H75080 probable homoserine kinase (EC 2.7.1.39) PAB1676 - P... 582 e-165
pir||D71103 probable homoserine kinase - Pyrococcus horikoshii >... 412 e-114
gb|AAG20015.1| (AE005082) homoserine kinase; ThrB [Halobacterium... 190 2e-47
sp|Q58504|KHSE_METJA HOMOSERINE KINASE (HK) >gi|2127974|pir||G64... 185 5e-46
gb|AAD33097.1|AF082525_1 (AF082525) homoserine kinase [Arabidops... 169 3e-41
gb|AAF63224.1| (AC002329) 3-hydroxy-3-methylglutaryl-coenzyme A ... 168 6e-41
pir||E72511 probable homoserine kinase APE2067 - Aeropyrum perni... 161 1e-38
emb|CAC11670.1| (AL445064) homoserine kinase related protein [Th... 147 1e-34
sp|O67332|KHSE_AQUAE HOMOSERINE KINASE (HK) >gi|7450507|pir||A70... 144 1e-33
gb|AAK42518.1| Homoserine kinase (thrB) [Sulfolobus solfataricus] 138 8e-32
sp|P04947|KHSE_FREDI HOMOSERINE KINASE (HK) >gi|79795|pir||S0374... 138 1e-31
pir||F82583 homoserine kinase XF2224 [imported] - Xylella fastid... 131 1e-29
sp|P27722|KHSE_SERMA HOMOSERINE KINASE (HK) >gi|421255|pir||C470... 129 4e-29
sp|P00547|KHSE_ECOLI HOMOSERINE KINASE (HK) >gi|1361027|pir||S56... 120 3e-26
sp|O66132|KHSE_BUCAI HOMOSERINE KINASE (HK) >gi|10038875|dbj|BAB... 120 3e-26
sp|P73646|KHSE_SYNY3 HOMOSERINE KINASE (HK) >gi|7450506|pir||S77... 116 3e-25
pir||B25364 homoserine kinase (EC 2.7.1.39) - Bacillus subtilis ... 115 7e-25
sp|P04948|KHSE_BACSU HOMOSERINE KINASE (HK) >gi|7450505|pir||H69... 115 9e-25
sp|P44504|KHSE_HAEIN HOMOSERINE KINASE (HK) >gi|1074209|pir||I64... 111 1e-23
pir||G82086 homoserine kinase VC2363 [imported] - Vibrio cholera... 109 3e-23
pir||G75280 homoserine kinase - Deinococcus radiodurans (strain ... 109 4e-23
sp|P72535|KHSE_STRPN HOMOSERINE KINASE (HK) >gi|1498295|gb|AAC44... 108 8e-23
sp|P52991|KHSE_LACLA HOMOSERINE KINASE (HK) >gi|2126613|pir||JC6... 105 6e-22
pir||B64651 homoserine kinase - Helicobacter pylori (strain 2669... 103 3e-21
dbj|BAB07139.1| (AP001518) homoserine kinase [Bacillus halodurans] 102 4e-21
pir||F81430 homoserine kinase (EC 2.7.1.39) Cj0134 [imported] - ... 102 6e-21
gb|AAG14699.1|AF293226_1 (AF293226) homoserine kinase [Escherich... 102 6e-21
gb|AAG14687.1|AF293220_1 (AF293220) homoserine kinase [Escherich... 101 1e-20
gb|AAG14703.1|AF293228_1 (AF293228) homoserine kinase [Escherich... 101 1e-20
gb|AAG14765.1|AF293259_1 (AF293259) homoserine kinase [Escherich... 101 1e-20
gb|AAG14779.1|AF293266_1 (AF293266) homoserine kinase [Escherich... 101 1e-20
gb|AAG14701.1|AF293227_1 (AF293227) homoserine kinase [Escherich... 101 1e-20
gb|AAG14767.1|AF293260_1 (AF293260) homoserine kinase [Escherich... 101 1e-20
gb|AAA83915.1| (J01706) homoserine kinase [Escherichia coli] >gi... 100 2e-20
gb|AAG14707.1|AF293230_1 (AF293230) homoserine kinase [Escherich... 100 2e-20
gb|AAG14777.1|AF293265_1 (AF293265) homoserine kinase [Escherich... 100 2e-20
gb|AAG14675.1|AF293214_1 (AF293214) homoserine kinase [Escherich... 100 2e-20
pir||C71940 homoserine kinase - Helicobacter pylori (strain J99)... 99 4e-20
gb|AAG14695.1|AF293224_1 (AF293224) homoserine kinase [Escherich... 99 6e-20
pir||F72364 hypothetical protein TM0545 - Thermotoga maritima (s... 92 9e-18
emb|CAC18626.1| (AL451109) probable homoserine kinase [Neurospor... 90 4e-17
pir||T40495 homoserine kinase - fission yeast (Schizosaccharomyc... 90 4e-17
sp|P45836|KHSE_MYCLE HOMOSERINE KINASE (HK) >gi|7434440|pir||T09... 83 4e-15
sp|P07128|KHSE_BRELA HOMOSERINE KINASE (HK) >gi|39588|emb|CAA683... 82 1e-14
sp|P08210|KHSE_CORGL HOMOSERINE KINASE (HK) >gi|66855|pir||KIFKM... 82 1e-14
sp|Q10603|KHSE_MYCTU HOMOSERINE KINASE (HK) >gi|7434439|pir||D70... 79 5e-14
>pir||H75080 probable homoserine kinase (EC 2.7.1.39) PAB1676 - Pyrococcus
abyssi (strain Orsay) >gi|5458461|emb|CAB49949.1|
(AJ248286) HOMOSERINE KINASE (EC 2.7.1.39) (HK).
[Pyrococcus abyssi]
Length = 294
Score = 582 bits (1484), Expect = e-165
Identities = 294/294 (100%), Positives = 294/294 (100%)
Query: 1 MKKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYDVPRDENNVAVIS 60
MKKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYDVPRDENNVAVIS
Sbjct: 1 MKKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYDVPRDENNVAVIS 60
Query: 61 AKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALE 120
AKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALE
Sbjct: 61 AKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALE 120
Query: 121 GEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVLPEVEVPTKEARRIV 180
GEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVLPEVEVPTKEARRIV
Sbjct: 121 GEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVLPEVEVPTKEARRIV 180
Query: 181 PEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLE 240
PEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLE
Sbjct: 181 PEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLE 240
Query: 241 AGAYGVTVSGSGPSLFAIGENLKDIGKAMKEKFEELGIRAEFWITKTGRGAKWY 294
AGAYGVTVSGSGPSLFAIGENLKDIGKAMKEKFEELGIRAEFWITKTGRGAKWY
Sbjct: 241 AGAYGVTVSGSGPSLFAIGENLKDIGKAMKEKFEELGIRAEFWITKTGRGAKWY 294
>pir||D71103 probable homoserine kinase - Pyrococcus horikoshii
>gi|3257503|dbj|BAA30186.1| (AP000004) 271aa long
hypothetical homoserine kinase [Pyrococcus horikoshii]
Length = 271
Score = 412 bits (1047), Expect = e-114
Identities = 195/270 (72%), Positives = 237/270 (87%)
Query: 23 MAIEEPGDEVIVKESDSFEIEVEGYDVPRDENNVAVISAKALFKMVGEEGGVKIRLKKGV 82
MAI++P DEV+V+E + FEI GY VP E+N+A+ SAK LFKM+ EGG++I+LKKG+
Sbjct: 1 MAIDKPFDEVVVEEFNEFEIISSGYPVPNGEDNIALFSAKTLFKMLNIEGGLRIKLKKGI 60
Query: 83 RPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALEGEKAASGSPHGDNVIPSYYGGF 142
RPKSGLGSSGAS+VAGAL AA++LGV NDELI+ AA++GE+ ASG PH DNV+PSYYGGF
Sbjct: 61 RPKSGLGSSGASAVAGALGAAKLLGVSNDELILKAAMKGEEKASGEPHPDNVVPSYYGGF 120
Query: 143 NILESLNPLRVHRVDVELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLA 202
++ES +PLRVH VD +L VVVLPEVE+PT +AR+I+P VPLKDA+KN+AMASSL+LA
Sbjct: 121 TVIESKSPLRVHFVDAKLRGVVVLPEVEIPTAKARKILPSMVPLKDAVKNIAMASSLILA 180
Query: 203 LKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAIGENL 262
LKEGD+ET+GRLLDDNLALPYRKKLMPWFDE+R+ LE GAYG+TVSGSGP+LFAIGENL
Sbjct: 181 LKEGDLETIGRLLDDNLALPYRKKLMPWFDEIRRVALETGAYGITVSGSGPALFAIGENL 240
Query: 263 KDIGKAMKEKFEELGIRAEFWITKTGRGAK 292
KDIGK + EKFEELGI+AE+W+TKTGRGAK
Sbjct: 241 KDIGKTIVEKFEELGIKAEYWVTKTGRGAK 270
>gb|AAG20015.1| (AE005082) homoserine kinase; ThrB [Halobacterium sp. NRC-1]
Length = 301
Score = 190 bits (478), Expect = 2e-47
Identities = 115/294 (39%), Positives = 166/294 (56%), Gaps = 16/294 (5%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYD---VPRD-ENNVAVIS 60
+ APAT AN G GFDVFG+A+ +P D V V+ +D+ I V G VP D + N A +
Sbjct: 5 VRAPATSANLGSGFDVFGVALSKPADVVRVERADTTTITVTGAGAQYVPTDPQENTAGVV 64
Query: 61 AKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVD-NDELIIMAAL 119
A AL + I + KGVRP SGLGSS AS+ A +A A + +D+ ++ AA
Sbjct: 65 AAAL------DAPATIHINKGVRPSSGLGSSAASAAAATVALAELYDRPLDDDALVRAAA 118
Query: 120 EGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVLPEVEVPTKEARRI 179
+GE AASG H DNV P+ GGF I+ + VD L + V LPE V T++AR +
Sbjct: 119 QGEAAASGVAHADNVAPAILGGFTIVREDG---IEHVDASLALAVCLPETTVSTRDARGV 175
Query: 180 VPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGL 239
VPE ++ + + A++L L + E D + VGR ++D L P R +LM ++ A
Sbjct: 176 VPESAAMEAVVSTVESAATLTLGMCENDPQRVGRGVEDALVTPARARLMDGYEAASAAAR 235
Query: 240 EAGAYGVTVSGSGPSLFAI--GENLKDIGKAMKEKFEELGIRAEFWITKTGRGA 291
+AGA GVT+SGSGP + A+ + K + A+ + F+ G+ A + T+ G GA
Sbjct: 236 DAGATGVTISGSGPGVVAVCRRRDRKRVAAALVDGFDSAGVAASAYQTRIGDGA 289
>sp|Q58504|KHSE_METJA HOMOSERINE KINASE (HK) >gi|2127974|pir||G64437 homoserine kinase
(EC 2.7.1.39) - Methanococcus jannaschii
>gi|1591748|gb|AAB99107.1| (U67553) homoserine kinase
(thrB) [Methanococcus jannaschii]
Length = 300
Score = 185 bits (465), Expect = 5e-46
Identities = 114/290 (39%), Positives = 173/290 (59%), Gaps = 11/290 (3%)
Query: 1 MKKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEI--EVEGYDVPRD-ENNVA 57
MK R+ AP T AN G GFDVFG+ ++EP D + V+ D EI EV+ ++P D + NVA
Sbjct: 5 MKVRVKAPCTSANLGVGFDVFGLCLKEPYDVIEVEAIDDKEIIIEVDDKNIPTDPDKNVA 64
Query: 58 VISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDEL-IIM 116
I AK + GVKI +KKGV+ SGLGSS ASS A A + ++ D+L ++
Sbjct: 65 GIVAKKMIDDFNIGKGVKITIKKGVKAGSGLGSSAASSAGTAYAINELFKLNLDKLKLVD 124
Query: 117 AALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRV--DVELNVVVVLPEVEVPTK 174
A GE A+SG+ H DNV P+ +GGF ++ + PL V + D +L++++ +P + + TK
Sbjct: 125 YASYGELASSGAKHADNVAPAIFGGFTMVTNYEPLEVLHIPIDFKLDILIAIPNISINTK 184
Query: 175 EARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGR-LLDDNLALPYRKKLMPWFDE 233
EAR I+P+ V LKD + N+ A +V AL D GR ++ D + P R KL+P + +
Sbjct: 185 EAREILPKAVGLKDLVNNVGKACGMVYALYNKDKSLFGRYMMSDKVIEPVRGKLIPNYFK 244
Query: 234 VRKAGLEAGAYGVTVSGSGPSLFAI--GENLKDIGKAMKEKFEELGIRAE 281
+ K ++ YG+T+SGSGPS+ A E + ++ +++ +E IR E
Sbjct: 245 I-KEEVKDKVYGITISGSGPSIIAFPKEEFIDEVENILRDYYENT-IRTE 292
>gb|AAD33097.1|AF082525_1 (AF082525) homoserine kinase [Arabidopsis thaliana]
Length = 370
Score = 169 bits (425), Expect = 3e-41
Identities = 111/294 (37%), Positives = 166/294 (55%), Gaps = 22/294 (7%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEI------EVEGYDVPRDEN--- 54
+ +APAT+AN GPGFD G A++ GD V ++ S E+ G N
Sbjct: 55 KTFAPATVANLGPGFDFLGCAVDGLGDHVTLRVDPSVRAGEVSISEITGTTTKLSTNPLR 114
Query: 55 NVAVISAKALFKMVGEEG-GVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLG--VDND 111
N A I+A A KM+G G+ + L KG+ SGLGSS AS+ A A+A + G + +D
Sbjct: 115 NCAGIAAIATMKMLGIRSVGLSLDLHKGLPLGSGLGSSAASAAAAAVAVNEIFGRKLGSD 174
Query: 112 ELIIMAALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRV----DVELNVVVVLP 167
+L++ A LE E SG H DN+ P+ GGF ++ + PL + + D +L V+V P
Sbjct: 175 QLVL-AGLESEAKVSGY-HADNIAPAIMGGFVLIRNYEPLDLKPLKFPSDKDLFFVLVSP 232
Query: 168 EVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLL-DDNLALPYRKK 226
E E PTK+ R +P ++P+ + N + A++LV A+ EGD +G+ L D + P R
Sbjct: 233 EFEAPTKKMRAALPTEIPMVHHVWNSSQAAALVAAVLEGDAVMLGKALSSDKIVEPTRAP 292
Query: 227 LMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI---GENLKDIGKAMKEKFEELG 277
L+P + V+KA LEAGA+G T+SG+GP+ A+ E + IG+ M E F ++G
Sbjct: 293 LIPGMEAVKKAALEAGAFGCTISGAGPTAVAVIDSEEKGQVIGEKMVEAFWKVG 346
>gb|AAF63224.1| (AC002329) 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
[Arabidopsis thaliana]
Length = 370
Score = 168 bits (422), Expect = 6e-41
Identities = 110/294 (37%), Positives = 166/294 (56%), Gaps = 22/294 (7%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEI------EVEGYDVPRDEN--- 54
+ +APAT+AN GPGFD G A++ GD V ++ S E+ G N
Sbjct: 55 KTFAPATVANLGPGFDFLGCAVDGLGDHVTLRVDPSVRAGEVSISEITGTTTKLSTNPLR 114
Query: 55 NVAVISAKALFKMVGEEG-GVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLG--VDND 111
N A I+A A KM+G G+ + L KG+ SGLGSS AS+ A A+A + G + +D
Sbjct: 115 NCAGIAAIATMKMLGIRSVGLSLDLHKGLPLGSGLGSSAASAAAAAVAVNEIFGRKLGSD 174
Query: 112 ELIIMAALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRV----DVELNVVVVLP 167
+L++ A LE E SG H DN+ P+ GGF ++ + PL + + D +L V+V P
Sbjct: 175 QLVL-AGLESEAKVSGY-HADNIAPAIMGGFVLIRNYEPLDLKPLRFPSDKDLFFVLVSP 232
Query: 168 EVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLD-DNLALPYRKK 226
+ E PTK+ R +P ++P+ + N + A++LV A+ EGD +G+ L D + P R
Sbjct: 233 DFEAPTKKMRAALPTEIPMVHHVWNSSQAAALVAAVLEGDAVMLGKALSSDKIVEPTRAP 292
Query: 227 LMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI---GENLKDIGKAMKEKFEELG 277
L+P + V+KA LEAGA+G T+SG+GP+ A+ E + IG+ M E F ++G
Sbjct: 293 LIPGMEAVKKAALEAGAFGCTISGAGPTAVAVIDSEEKGQVIGEKMVEAFWKVG 346
>pir||E72511 probable homoserine kinase APE2067 - Aeropyrum pernix (strain K1)
>gi|5105765|dbj|BAA81077.1| (AP000063) 343aa long
hypothetical homoserine kinase [Aeropyrum pernix]
Length = 343
Score = 161 bits (402), Expect = 1e-38
Identities = 108/287 (37%), Positives = 157/287 (54%), Gaps = 18/287 (6%)
Query: 2 KKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDS----FEIEVEGY--DVPRDENN 55
+ R A ++ AN GPGFD +A++ DEV V+ + EVEG N
Sbjct: 35 RARARAYSSAANLGPGFDALAVALDAYYDEVEVRVCSGGNSVYVDEVEGKFSSGVLQGPN 94
Query: 56 VAVISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDN--DEL 113
A + + L M G E V IR+ KGV P GLGSSGAS+ A A + L ++ D L
Sbjct: 95 TAAEAVRGLLNMEGVEAEVGIRVYKGVPPGRGLGSSGASAAAAVAAVSHALALEVPVDRL 154
Query: 114 IIMAALEGEKAASGSPHGDNVIPSYYGGFNILES--LNPLRVHRVDVELNVVVVLPEVEV 171
+ A L GE+AA+G PH DN S GG ++ S LRV RV + VV P V
Sbjct: 155 VFYAGL-GERAAAGQPHFDNAAASILGGLAVVASDAAGKLRVFRVPFKAWFAVVTPMNPV 213
Query: 172 P---TKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLL-DDNLALPYRKKL 227
P T R+++PE V +DA++N + A+ +V A GD++++G L+ D + P R+
Sbjct: 214 PQGKTGVMRKVLPENVSFRDAVRNFSRAAGIVAAAVNGDLKSMGALMMSDEIVEPRRRSY 273
Query: 228 MPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI---GENLKDIGKAMKE 271
+P + +VRKA L+AGA G ++SG+GPS+ A+ E ++I AM+E
Sbjct: 274 VPCYTQVRKAALQAGALGFSLSGAGPSMIALAPSSEAAREIAAAMEE 320
>emb|CAC11670.1| (AL445064) homoserine kinase related protein [Thermoplasma
acidophilum]
Length = 310
Score = 147 bits (368), Expect = 1e-34
Identities = 93/266 (34%), Positives = 151/266 (55%), Gaps = 10/266 (3%)
Query: 7 APATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYDVPRD-ENNVAVISAKALF 65
AP + AN G GFD +A++ D V + + D F++ EG +P D E N A ++A AL
Sbjct: 10 APCSSANLGSGFDTLAIALDAFHDRVTISDHDGFKLTGEG--IPLDPERNTAGLAAIALL 67
Query: 66 KMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAG--ALAAARVLGVDNDELIIMAALEGEK 123
+G E ++IR++KGV GLGSSGAS+ A AL A LG+ +E+I A + GE
Sbjct: 68 DELGLERDIEIRIEKGVPKGLGLGSSGASAAAAVKALDAYFGLGLTQEEMIGYAMI-GEI 126
Query: 124 AASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDV--ELNVVVVLPEV--EVPTKEARRI 179
A+SGSPH DNV S GG ++ + LR R+++ + +V +P++ E T+ AR++
Sbjct: 127 ASSGSPHPDNVSASIIGGLVLVTHDDDLRASRINISGDYRFLVAIPDLFTENKTRAARQM 186
Query: 180 VPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGL 239
+P +PL K L +SL+ L G+ + ++D++ P R L P++ ++++ L
Sbjct: 187 LPRSIPLDSYSKALGRTASLIAGLMSGNRNLIRVGMNDDIVEPSRISLFPYYYDMKRMAL 246
Query: 240 EAGAYGVTVSGSGPSLFAIGENLKDI 265
A VSG+GPS+ + + + D+
Sbjct: 247 ANEAVAAAVSGAGPSILMVCDEMSDM 272
>sp|O67332|KHSE_AQUAE HOMOSERINE KINASE (HK) >gi|7450507|pir||A70413 homoserine kinase -
Aquifex aeolicus >gi|2983721|gb|AAC07283.1| (AE000733)
homoserine kinase [Aquifex aeolicus]
Length = 297
Score = 144 bits (359), Expect = 1e-33
Identities = 100/303 (33%), Positives = 164/303 (54%), Gaps = 21/303 (6%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYD--VPRDENNVAVISA 61
+I PAT NFG GFD FG+A+ + V SD +E+++EGY +P+D+ N+ +
Sbjct: 3 KIEVPATTTNFGSGFDTFGLALSLT-NTFSVDFSDKYEVQIEGYSSGIPKDQKNLFIKVY 61
Query: 62 KALFKMVGEEGG-VKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVD---NDELIIMA 117
K + +G++ +K+ + V P GLGSS + V G AA + V+ ++L I
Sbjct: 62 KKTCQSIGKKPKPLKLIQENRVPPARGLGSSATAIVGGIEAALALHKVELPLKEKLKI-- 119
Query: 118 ALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHR---VDVELNVVVVLPEVEVPTK 174
A E EK H DN+IP++ GGF + + + + ++ +V V+P+ EV T
Sbjct: 120 AFEFEK------HPDNIIPAFVGGFTVCATSESGVIFKKLPFPEDIKIVFVIPDFEVSTS 173
Query: 175 EARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEV 234
EARR++P+KV LK+A+ N+ ++ V AL D + + + D L PYR+KL+P E
Sbjct: 174 EARRVLPKKVELKEAVFNVQRSALFVSALLTKDYKLLREAVRDKLHQPYREKLVPGLSEA 233
Query: 235 RKAGLEAGAYGVTVSGSGPSLFAI-GENLKDIGKAMKEKFEEL-GIRAEFWITKT-GRGA 291
+ GA +SG+GP++ ++ EN + IG+A++E + G A+ + K G
Sbjct: 234 ILVSYKEGALATFLSGAGPTICSLTTENEEKIGEAIREVITKFSGYDAQVMVLKARNEGV 293
Query: 292 KWY 294
K Y
Sbjct: 294 KVY 296
>gb|AAK42518.1| Homoserine kinase (thrB) [Sulfolobus solfataricus]
Length = 311
Score = 138 bits (344), Expect = 8e-32
Identities = 89/279 (31%), Positives = 152/279 (53%), Gaps = 10/279 (3%)
Query: 3 KRIYAPATIANFGPGFDVFGMAIEEPGD--EVIVKESDSFEIEVEGYD-VPRDEN-NVAV 58
KR A ++ AN G GFD+ +A D E+ V+ + I VE +P + N N A
Sbjct: 4 KRARAYSSSANLGSGFDILSIAHTAFFDTVEICVENKNLNNIIVESNSKIPLEPNKNSAT 63
Query: 59 ISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVD-NDELIIMA 117
+ + +G + +K+R+ KG+ GLGSSGAS+ A +A + ++ + E ++
Sbjct: 64 YPIVKIMEEIGIKASLKVRVIKGIPEGLGLGSSGASAAAAVMAFNNLFNLNLSKEDLVRY 123
Query: 118 ALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVL-----PEVEVP 172
A+ GE A+SGSPH DNV S +GG + S++P++V + + + ++L +E
Sbjct: 124 AMYGEIASSGSPHPDNVAASVFGGVVSVVSVSPVKVVEIPINYSFDILLFTPLNVHIEEK 183
Query: 173 TKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFD 232
TK+AR +VP+ V L D I N SSL+L +G+ E + L+D + R L P++
Sbjct: 184 TKKAREMVPKTVTLSDYINNSRYISSLLLGFIKGERELIRLGLNDKIVEKARLPLFPYYP 243
Query: 233 EVRKAGLEAGAYGVTVSGSGPSLFAIGENLKDIGKAMKE 271
++++ ++ A G VSG+GPS+ + + + D K ++E
Sbjct: 244 KIKEVAIKYDAIGACVSGAGPSILVLTDKMTDENKIVEE 282
>sp|P04947|KHSE_FREDI HOMOSERINE KINASE (HK) >gi|79795|pir||S03743 homoserine kinase (EC
2.7.1.39) [validated] - Calothrix sp. (PCC 7601)
>gi|43396|emb|CAA68576.1| (Y00522) homoserine kinase (AA
1-307) [Calothrix PCC7601]
Length = 307
Score = 138 bits (343), Expect = 1e-31
Identities = 98/287 (34%), Positives = 150/287 (52%), Gaps = 15/287 (5%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVK-ESDSFEIEVEGYD---VPRDENNVAVIS 60
+ PAT AN GPGFD G A+ + ++ I V G + V DE+N+ +
Sbjct: 9 VTVPATTANLGPGFDCIGAALTLYNKVKFTRLDAGGLIIHVTGKEAEGVNTDESNLLYQA 68
Query: 61 AKALFKMVGE-EGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAAL 119
L++ + + VKI + GV GLGSS + V G +AA ++ G +L +M
Sbjct: 69 FVKLYQHIEQIPPSVKIEIDLGVPLARGLGSSATAIVGGLVAANQLAGEPLSQLQVM--- 125
Query: 120 EGEKAASGSPHGDNVIPSYYGGFNILE-SLNPLRVHRVDVELNVV--VVLPEVEVPTKEA 176
E A + H DNV+P+ GG + S + V + NVV V +P+ E+ T+EA
Sbjct: 126 --ELAIAMEGHPDNVVPALLGGCRLAATSAEGWEICDVPWDENVVPVVAIPDFELSTQEA 183
Query: 177 RRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRK 236
RR++P + DAI N A L+ L G E + L D L PYRK L+P +D V +
Sbjct: 184 RRVLPTEFSRADAIFNTAHLGLLLRGLATGKGEWLKTALQDKLHQPYRKALIPGYDAVNQ 243
Query: 237 AGLEAGAYGVTVSGSGPSLFAI--GENLKDIGKAMKEKFEELGIRAE 281
A + AGAYG+ +SG+GP+L A+ +N + + AM+ ++ +GI A+
Sbjct: 244 AAVAAGAYGMVISGAGPTLLALADAQNSQAVAAAMQTAWQTVGITAD 290
>pir||F82583 homoserine kinase XF2224 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9107373|gb|AAF85023.1|AE004035_2 (AE004035)
homoserine kinase [Xylella fastidiosa]
Length = 322
Score = 131 bits (326), Expect = 1e-29
Identities = 91/292 (31%), Positives = 149/292 (50%), Gaps = 11/292 (3%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEV---EGYDVP---RDENNVA 57
R +APA++AN GFD+ G +++ GD V V+ D+ ++ + G P + E N A
Sbjct: 22 RAFAPASVANVAVGFDLLGYPMDQVGDTVTVRRIDTPQVRIAAIRGIAQPLPLQTERNTA 81
Query: 58 VISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVD-NDELIIM 116
+ ++ + + G ++ + KG+ SG+G S AS VA LAA +L E +
Sbjct: 82 GAALLSMHRDLALPFGFELEIDKGIPLSSGMGGSAASCVAALLAANALLEEPLRREHLYR 141
Query: 117 AALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVLPEVEVPTKEA 176
AL+GE ASGS HGDN+ P + GG +L +L L V + ++V P+ + T+ A
Sbjct: 142 YALDGEAVASGSRHGDNLGPLFLGGL-VLCTLERLVPVTVPAAWHSLLVHPDTLLETRRA 200
Query: 177 RRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRK 236
R ++ + L D + A + ++ GD E V L D L P R L+ F ++
Sbjct: 201 REVLKDPYLLPDIVTQSANLALVLAGCYHGDAELVRAGLRDVLIEPRRAPLIAGFTAAQQ 260
Query: 237 AGLEAGAYGVTVSGSGPSLFAIGEN---LKDIGKAMKEKFEELGIRAEFWIT 285
A L+A A G ++SG+GPS+FA + + A++ F G ++ W+T
Sbjct: 261 AALQADAMGASISGAGPSVFAWFQTRSAAEAAAPAVRAAFTAAGFDSQAWVT 312
>sp|P27722|KHSE_SERMA HOMOSERINE KINASE (HK) >gi|421255|pir||C47057 homoserine kinase (EC
2.7.1.39) - Serratia marcescens
>gi|47274|emb|CAA43213.1| (X60821) homoserine kinase
[Serratia marcescens] >gi|216967|dbj|BAA38482.1|
(D10387) homoserine kinase [Serratia marcescens]
Length = 309
Score = 129 bits (321), Expect = 4e-29
Identities = 91/268 (33%), Positives = 136/268 (49%), Gaps = 14/268 (5%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEP-----GDEVIVKESDSFEIEVEGYDVPR----DEN 54
++YAPA+I N GFDV G A+ GD V V+ +++F ++ G V + +
Sbjct: 3 KVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVEAAETFSLQNAGRFVSKLPAEPKE 62
Query: 55 NVAVISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELI 114
N+ + + +G E V +RL+K + SGLGSS S VAG +A D+
Sbjct: 63 NIVYQCWERFCQEIGREVPVAMRLEKNMPIGSGLGSSACSVVAGLMAMNEFCDRPLDKTT 122
Query: 115 IMAAL-EGEKAASGSPHGDNVIPSYYGGFNIL---ESLNPLRVHRVDVELNVVVVLPEVE 170
++ + E E SGS H DNV P Y GG ++ E + V D L V+ P ++
Sbjct: 123 LLGLMGELEGRISGSVHYDNVAPCYLGGLQLMLEEEGIISQEVPCFDDWL-WVMAYPGIK 181
Query: 171 VPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPW 230
V T EAR I+P + +D I + + + A + +L+ D +A PYR +L+P
Sbjct: 182 VSTAEARAILPAQYRRQDCISHGRYLAGFIHACHTRQPQLAAKLMQDVIAEPYRTRLLPG 241
Query: 231 FDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
F E RKA E GA +SGSGP+LFA+
Sbjct: 242 FAEARKAAQEIGALACGISGSGPTLFAV 269
>sp|P00547|KHSE_ECOLI HOMOSERINE KINASE (HK) >gi|1361027|pir||S56630 homoserine kinase
(EC 2.7.1.39) thrB - Escherichia coli
>gi|7428038|pir||KIECM homoserine kinase (EC 2.7.1.39) -
Escherichia coli >gi|529240|gb|AAA20618.1| (L13601)
homoserine kinase [Escherichia coli]
>gi|537246|gb|AAA97302.1| (U14003) homoserine kinase
[Escherichia coli] >gi|1786184|gb|AAC73114.1| (AE000111)
homoserine kinase [Escherichia coli K12]
Length = 310
Score = 120 bits (297), Expect = 3e-26
Identities = 88/269 (32%), Positives = 134/269 (49%), Gaps = 16/269 (5%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEP-----GDEVIVKESDSFEIEVEGYDVPR----DEN 54
++YAPA+ AN GFDV G A+ GD V V+ +++F + G +
Sbjct: 3 KVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRE 62
Query: 55 NVAVISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGV---DND 111
N+ + + +G++ V + L+K + SGLGSS S VA +A G D
Sbjct: 63 NIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTR 122
Query: 112 ELIIMAALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDV--ELNVVVVLPEV 169
L +M LEG SGS H DNV P + GG ++ N + +V E V+ P +
Sbjct: 123 LLALMGELEGR--ISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGI 180
Query: 170 EVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMP 229
+V T EAR I+P + +D I + + + A E +L+ D +A PYR++L+P
Sbjct: 181 KVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLP 240
Query: 230 WFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
F + R+A E GA +SGSGP+LFA+
Sbjct: 241 GFRQARQAVAEIGAVASGISGSGPTLFAL 269
>sp|O66132|KHSE_BUCAI HOMOSERINE KINASE (HK) >gi|10038875|dbj|BAB12910.1| (AP001118)
homoserine kinase [Buchnera sp. APS]
Length = 309
Score = 120 bits (297), Expect = 3e-26
Identities = 93/278 (33%), Positives = 136/278 (48%), Gaps = 16/278 (5%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEP-----GDEVIVKESDSFEIEVEGY---DVPRD-EN 54
+IYAPA+I N G GFD+ G AI GD V VK S+ F + +G +P++ E
Sbjct: 3 KIYAPASIGNVGVGFDILGAAIIPVNGSLLGDFVTVKLSNKFNLVNKGIFSNKLPKNTEQ 62
Query: 55 NVAVISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGV---DND 111
N+ + V I L+K + SGLGSS S VA +A +
Sbjct: 63 NIVWKCWLKFCNTIKRNIPVSIILEKNMPIGSGLGSSACSIVATLVAMNEFCDKPLNSKE 122
Query: 112 ELIIMAALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNV--VVVLPEV 169
L++M +EGE SGS H DNV P Y GG ++ + + + N +V P
Sbjct: 123 LLLLMGEVEGE--ISGSIHYDNVAPCYLGGLQLILEDSKIISQTIPNFKNWFWIVAWPGT 180
Query: 170 EVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMP 229
+VPT EAR I+P+K + IKN + + A RL+ D +A PYR KL+P
Sbjct: 181 KVPTAEARDILPKKYKKETCIKNSRYLAGFIHASYSQQPHLAARLMQDFIAEPYRIKLLP 240
Query: 230 WFDEVRKAGLEAGAYGVTVSGSGPSLFAIGENLKDIGK 267
+ V++ + GA +SGSGP++F+I +N+ K
Sbjct: 241 NYLYVKEKIKKIGAISSGISGSGPTIFSISDNINTAQK 278
>sp|P73646|KHSE_SYNY3 HOMOSERINE KINASE (HK) >gi|7450506|pir||S77133 homoserine kinase
(EC 2.7.1.39) - Synechocystis sp. (strain PCC 6803)
>gi|1652772|dbj|BAA17691.1| (D90908) homoserine kinase
[Synechocystis sp.]
Length = 306
Score = 116 bits (288), Expect = 3e-25
Identities = 88/292 (30%), Positives = 145/292 (49%), Gaps = 23/292 (7%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVKESD---SFEIEVEGYD---VPRDENNVAV 58
+ PAT AN GPGFD G A+ + +D IE G D + ++N+
Sbjct: 6 VSVPATTANIGPGFDCLGAALGLYNHVTVTDPTDPEVDLLIEARGRDGEKISTTKDNLLY 65
Query: 59 ISAKALFKMVGEE-GGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLG--VDNDELII 115
+ ++ G+ +K+ + + GLGSS + V G LAA + G E++
Sbjct: 66 QAIAYFYQQTGQAIPPLKLEIDLEIPLARGLGSSATAIVGGLLAANQAAGNPCTTSEILQ 125
Query: 116 MA-ALEGEKAASGSPHGDNVIPSYYGGFNI-LESLNPLRVHRVDVELNVVVVL--PEVEV 171
MA A+EG H DNV P+ GG + +++ + ++ +D V VL P E+
Sbjct: 126 MAIAMEG--------HPDNVAPALLGGCQLAVKNGDHWQLVALDWPSKFVPVLAIPNFEL 177
Query: 172 PTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWF 231
T+ AR ++P + AI N + + LV A +G + + L D + PYR+ L+P +
Sbjct: 178 STEAARAVLPHQYDRSAAIFNASHLALLVQAFSQGRGDWLALALQDQIHQPYRQSLIPAY 237
Query: 232 DEVRKAGLEAGAYGVTVSGSGPSLFAIGENLK--DIGKAMKEKFEELGIRAE 281
D++ +A L AGAY + +SG+GP+L AI + ++ I + E + + GI AE
Sbjct: 238 DQLHQAALAAGAYNLVISGAGPTLLAIADEVRAPQIASTLVETWHDAGIEAE 289
>pir||B25364 homoserine kinase (EC 2.7.1.39) - Bacillus subtilis
>gi|40212|emb|CAA28271.1| (X04603) homoserine kinase
[Bacillus subtilis]
Length = 308
Score = 115 bits (285), Expect = 7e-25
Identities = 92/277 (33%), Positives = 145/277 (52%), Gaps = 20/277 (7%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVKESD--SFEIEVEGYDVPRDENNVAVISAK 62
+ P + AN GPGFD GMA+ ++ V ESD SFE E E R +N+ AK
Sbjct: 10 VTVPGSTANLGPGFDSVGMALSRYL-KLTVFESDKWSFEAETETVAGIRGTDNLIYQVAK 68
Query: 63 ALFKMVGEE-GGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGV---DNDELIIMAA 118
+ G+E V +++ + GLGSS A+ VA A + G+ + D+L + +
Sbjct: 69 RTADLYGKEMPPVHVKVWSDIPLARGLGSSAAAIVAAIELADELCGLKLSEADKLHLASL 128
Query: 119 LEGEKAASGSPHGDNVIPSYYGGFNI-LESLNPLRVHRV-DVELNVVVVLPEVEVPTKEA 176
EG H DN S GG I L + ++ RV + +++VVVV+P EV T++A
Sbjct: 129 EEG--------HPDNAGASLVGGLVIGLHEDDETQMIRVPNADIDVVVVIPFYEVLTRDA 180
Query: 177 RRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLL-DDNLALPYRKKLMPWFDEVR 235
R ++P++ P DA+K A+++ L+ A+ D VG+++ D PYR L+P +V
Sbjct: 181 RDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGKIMKKDMFHQPYRAMLVPELSKVE 240
Query: 236 KAGLEAGAYGVTVSGSGPSLFAIGENLKDIGKAMKEK 272
GAYG +SG+GP++ + E K G+ +KE+
Sbjct: 241 HVAEMKGAYGTALSGAGPTILVMTE--KGKGEELKEQ 275
>sp|P04948|KHSE_BACSU HOMOSERINE KINASE (HK) >gi|7450505|pir||H69722 homoserine kinase
(EC 2.7.1.39) - Bacillus subtilis
>gi|2635721|emb|CAB15214.1| (Z99120) homoserine kinase
[Bacillus subtilis]
Length = 309
Score = 115 bits (284), Expect = 9e-25
Identities = 92/278 (33%), Positives = 146/278 (52%), Gaps = 21/278 (7%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVKESD--SFEIEVEGY-DVPRDENNVAVISA 61
+ P + AN GPGFD GMA+ ++ V ESD SFE E E +P +N+ A
Sbjct: 10 VTVPGSTANLGPGFDSVGMALSRYL-KLTVFESDKWSFEAETETVAGIPAGTDNLIYQVA 68
Query: 62 KALFKMVGEE-GGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGV---DNDELIIMA 117
K + G+E V +++ + GLGSS A+ VA A + G+ + D+L + +
Sbjct: 69 KRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAAIVAAIELADELCGLKLSEADKLHLAS 128
Query: 118 ALEGEKAASGSPHGDNVIPSYYGGFNI-LESLNPLRVHRV-DVELNVVVVLPEVEVPTKE 175
EG H DN S GG I L + ++ RV + +++VVVV+P EV T++
Sbjct: 129 LEEG--------HPDNAGASLVGGLVIGLHEDDETQMIRVPNADIDVVVVIPFYEVLTRD 180
Query: 176 ARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLL-DDNLALPYRKKLMPWFDEV 234
AR ++P++ P DA+K A+++ L+ A+ D VG+++ D PYR L+P +V
Sbjct: 181 ARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGKIMKKDMFHQPYRAMLVPELSKV 240
Query: 235 RKAGLEAGAYGVTVSGSGPSLFAIGENLKDIGKAMKEK 272
GAYG +SG+GP++ + E K G+ +KE+
Sbjct: 241 EHVAEMKGAYGTALSGAGPTILVMTE--KGKGEELKEQ 276
>sp|P44504|KHSE_HAEIN HOMOSERINE KINASE (HK) >gi|1074209|pir||I64047 homoserine kinase
(EC 2.7.1.39) - Haemophilus influenzae (strain Rd KW20)
>gi|1573039|gb|AAC21766.1| (U32694) homoserine kinase
(thrB) [Haemophilus influenzae Rd]
Length = 314
Score = 111 bits (275), Expect = 1e-23
Identities = 93/278 (33%), Positives = 136/278 (48%), Gaps = 19/278 (6%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEP-----GDEVIVKE-SDSFEIEVEGYDV---PRDEN 54
RIYAPA+ AN GFD G AI GD V ++ S FE+E GY V P++
Sbjct: 3 RIYAPASSANISVGFDTLGAAISPIDGSLLGDVVQIESISTGFELESAGYFVRKLPKEPQ 62
Query: 55 NVAVISAKALFKMVGEEGGVKIR-----LKKGVRPKSGLGSSGASSVAGALAAARVLGVD 109
V A LF + G ++ L+K + SGLGSS S VA +A +
Sbjct: 63 KNIVYQAYVLFSEQLKLRGANVKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHNEP 122
Query: 110 NDELIIMAAL-EGEKAASGSPHGDNVIPSYYGGFNIL-ESLNPLRVHRVDVELNVVVVL- 166
++ ++ + E E SGS H DNV P Y GG + +SL + ++ N VL
Sbjct: 123 FSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQFMVQSLGNI-CQKLPFFDNWYWVLA 181
Query: 167 -PEVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRK 225
P +EV T EAR I+P+ ++ I + V A ++ D +A PYR+
Sbjct: 182 YPGIEVSTAEARAILPKSYTRQNVIAHGRHLGGFVHACHTHQENLAAIMMKDVIAEPYRE 241
Query: 226 KLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAIGENLK 263
L+P F EV++A + GA +SGSGP++F+I +L+
Sbjct: 242 SLLPNFAEVKQATRDLGALATGISGSGPTIFSIAPDLQ 279
>pir||G82086 homoserine kinase VC2363 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9656932|gb|AAF95506.1| (AE004306)
homoserine kinase [Vibrio cholerae]
Length = 318
Score = 109 bits (271), Expect = 3e-23
Identities = 89/275 (32%), Positives = 135/275 (48%), Gaps = 25/275 (9%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEP-----GDEVIVKE-SDSFEIEVEGYDV---PRDENN 55
+YAPA+I N GFDV G A+ GD V V+ +++F ++ G V P +
Sbjct: 5 VYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVKVEAGAEAFTLKTAGRFVDKLPANPQE 64
Query: 56 VAVISAKALFKMVGEEGGVKIR-----LKKGVRPKSGLGSSGASSVAG--ALAAARVLGV 108
V +F E+ V ++ L+K + SGLGSS S VA AL +
Sbjct: 65 NIVYDCWQVFARELEKKSVVLKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFHASPL 124
Query: 109 DNDELI-IMAALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDV----ELNVV 163
D EL+ +M +EG+ SGS H DNV P Y GG ++ L L + V + V
Sbjct: 125 DETELLALMGEMEGK--ISGSIHYDNVAPCYLGGVQLM--LEELGIISQSVPSFDDWYWV 180
Query: 164 VVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPY 223
+ P ++V T EAR I+P + +D + + + + A E +++ D +A PY
Sbjct: 181 MAYPGIKVSTAEARAILPAQYRRQDIVAHGRYLAGFIHACHTQQPELAAKMIKDVIAEPY 240
Query: 224 RKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
R+KL+P F + R AGA +SGSGP+LF++
Sbjct: 241 REKLLPGFAKARNYAASAGALATGISGSGPTLFSV 275
>pir||G75280 homoserine kinase - Deinococcus radiodurans (strain R1)
>gi|6460205|gb|AAF11935.1|AE002069_9 (AE002069)
homoserine kinase [Deinococcus radiodurans]
Length = 307
Score = 109 bits (270), Expect = 4e-23
Identities = 76/259 (29%), Positives = 130/259 (49%), Gaps = 15/259 (5%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGY---DVPRDENNVAVISA 61
+ APA+ AN GPGFD G+++ + V D E+ G D P DE+N +
Sbjct: 10 VRAPASSANLGPGFDSLGLSVPLY-TTLRVTPQDKAEVVPLGTELADTPADESNYVYRAM 68
Query: 62 KALFKMVGEE-GGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALE 120
K G ++ ++ V GLGSS A+ VAG +A +LG D+ ++
Sbjct: 69 TLAAKRAGRTLPPARVEIETEVPLARGLGSSAAALVAGVVAGNELLGRPLDDETVLDVTA 128
Query: 121 GEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVE----LNVVVVLPEVEVPTKEA 176
E+ H DNV P+ +GG ++ +L+ L H V ++ L V V++P+ E+ T +A
Sbjct: 129 REEG-----HPDNVAPALFGGI-VVATLDKLGTHYVRLDPPAHLGVTVLVPDFELSTSKA 182
Query: 177 RRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRK 236
R ++P + D + L+ A+ L AL +G ++ + + D + +R L+P ++ +
Sbjct: 183 RAVLPREYSRADTVHALSHAALLAAALAQGRLDLLRHAMQDYVHQVWRAPLVPGLSDILE 242
Query: 237 AGLEAGAYGVTVSGSGPSL 255
E GA G +SG+GP++
Sbjct: 243 HAHEYGALGAALSGAGPTV 261
>sp|P72535|KHSE_STRPN HOMOSERINE KINASE (HK) >gi|1498295|gb|AAC44297.1| (U41735)
homoserine kinase homolog [Streptococcus pneumoniae]
Length = 289
Score = 108 bits (267), Expect = 8e-23
Identities = 81/269 (30%), Positives = 142/269 (52%), Gaps = 22/269 (8%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVE-GYDVPRDENNVAVISAK 62
+I PAT AN GPGFD G+A+ + + +E D + IE + G +P DE N+ + A
Sbjct: 2 KIIVPATSANIGPGFDSVGVAVTKYLQIEVSEERDEWLIEHQIGKWIPHDERNLLLTIA- 60
Query: 63 ALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGV----DNDELIIMAA 118
++V + ++++ V GLGSS + VAG + A LG D+++L +
Sbjct: 61 --LQIVPDLQPRRLKMTSDVPLARGLGSSSSVIVAG-IELANQLGQLNLSDHEKLQLATK 117
Query: 119 LEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDV---ELNVVVVLPEVEVPTKE 175
+EG H DNV P+ YG I S+ +V + E + + +P E+ T++
Sbjct: 118 IEG--------HPDNVAPAIYGNLVIASSVEG-QVSAIVADFPECDFLAYIPNYELRTRD 168
Query: 176 ARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALP-YRKKLMPWFDEV 234
+R ++P+K+ K+A+ ++A+ V AL GD+ T G+ ++ +L YR+ L+ F +
Sbjct: 169 SRSVLPKKLSYKEAVAASSIANVAVAALLAGDMVTAGQAIEGDLFHERYRQDLVREFAMI 228
Query: 235 RKAGLEAGAYGVTVSGSGPSLFAIGENLK 263
++ E GAY +SG+GP++ + + K
Sbjct: 229 KQVTKENGAYATYLSGAGPTVMVLASHDK 257
>sp|P52991|KHSE_LACLA HOMOSERINE KINASE (HK) >gi|2126613|pir||JC6050 homoserine kinase
(EC 2.7.1.39) - Lactococcus lactis
>gi|1255940|emb|CAA65714.1| (X96988) thrB [Lactococcus
lactis]
Length = 296
Score = 105 bits (260), Expect = 6e-22
Identities = 76/264 (28%), Positives = 137/264 (51%), Gaps = 17/264 (6%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVE-GYDVPRDENNVAVISAK 62
+I PAT AN G GFD G+A+ ++ ES ++I+ + G ++P DE N+ + +
Sbjct: 2 KIIVPATSANLGAGFDSIGIAVNLYLTVEVLGESRDWKIDHDLGENIPTDERNLLLTTLS 61
Query: 63 ALF--KMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARV--LGVDNDELIIMAA 118
A+ K V +++ V GLGSS + +AG A ++ L + +DE + +A
Sbjct: 62 AVLEDKNVALSAKFHLKMTSEVPLARGLGSSSSVIIAGIELANQLAKLNLTSDEKLKLAC 121
Query: 119 -LEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVD--VELNVVVVLPEVEVPTKE 175
+EG H DNV P+ G I ++ H V ++ +P+ E+ T E
Sbjct: 122 EIEG--------HPDNVAPALLGNLVIASTVAGKTSHIVADFPSCALLAFVPDYELKTVE 173
Query: 176 ARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLD-DNLALPYRKKLMPWFDEV 234
+R+++P ++ K+A+ ++A+ L +L ++E G++++ D YR L+P +
Sbjct: 174 SRKVLPNELTYKEAVAASSIANVLTASLLTNNLEVAGQMMEADRFHESYRASLIPELQLL 233
Query: 235 RKAGLEAGAYGVTVSGSGPSLFAI 258
R+ G E GAYG +SG+GP++ +
Sbjct: 234 REIGHEFGAYGTYLSGAGPTVMLL 257
>pir||B64651 homoserine kinase - Helicobacter pylori (strain 26695)
>gi|2314197|gb|AAD08095.1| (AE000612) homoserine kinase
(thrB) [Helicobacter pylori 26695]
Length = 293
Score = 103 bits (254), Expect = 3e-21
Identities = 79/282 (28%), Positives = 136/282 (48%), Gaps = 14/282 (4%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVKES-DSFEIEVEGYDVPRD-ENNVAVISAK 62
+ PAT AN GPGFD G+++ I S + ++ EG +P+ NN+
Sbjct: 3 VSVPATSANLGPGFDCLGLSLNLRNRFFIEPSSFHAVKLVGEGEGIPKFLTNNIFTKVFY 62
Query: 63 ALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDND-ELIIMAALEG 121
+ K G +G K L V G+GSS A V +A LG D D E I+ AL
Sbjct: 63 EILKKHGNDGSFKFLLHNKVPITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTALIY 122
Query: 122 EKAASGSPHGDNVIPSYYGGFN--ILESLNPLRVH-RVDVELNVVVVLPEVEVPTKEARR 178
E H DN+ P+ +GG+N +E + + ++ L V+V+P + TK++R
Sbjct: 123 EN------HPDNITPAVFGGYNAAFVEKKKVISLKTKIPSFLKAVMVIPNRAISTKQSRH 176
Query: 179 IVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAG 238
++P++ +++++ NL+ AS + +A+ +G + + D + R + P ++K
Sbjct: 177 LLPKRYSVQESVFNLSHASLMTMAIVQGKWDLLRCCSKDRMHQYKRMQTYPVLFAIQKIA 236
Query: 239 LEAGAYGVTVSGSGPSLF--AIGENLKDIGKAMKEKFEELGI 278
LE A T+SGSG S F E+ + + + +KF + +
Sbjct: 237 LENNALMSTLSGSGSSFFNMCYEEDAPKLKQVLSKKFPKFRV 278
>dbj|BAB07139.1| (AP001518) homoserine kinase [Bacillus halodurans]
Length = 309
Score = 102 bits (253), Expect = 4e-21
Identities = 80/266 (30%), Positives = 136/266 (51%), Gaps = 20/266 (7%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGYD---VPRDENNVAVIS 60
+I P + AN GPGFD G+A+ + V E + + D +P + N+
Sbjct: 6 QITVPGSSANLGPGFDSVGLAVNRYLT-LTVTEGSEWHFSTQSADLVGIPSGKENLVYQV 64
Query: 61 AKALFKMVGEE-GGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLG---VDNDELIIM 116
A+ + + + ++++ + GLGSS A+ VAG A ++LG D++
Sbjct: 65 AEHVASQLEKTLPPCHVQMESNIPLARGLGSSAAAIVAGIELANQLLGQPLAAEDKVRFG 124
Query: 117 AALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLR--VHRVDVELNVVVVLPEVEVPTK 174
+ EG H DN+ PS YGG I L+ +H +L++V+++P+ E+ TK
Sbjct: 125 SLWEG--------HPDNIAPSVYGGLVIGTHLSTETHVIHGGVPDLDLVLLVPKEELLTK 176
Query: 175 EARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLL-DDNLALPYRKKLMPWFDE 233
+AR I+PE + K+A++ ++++ LV AL + + E VG ++ D PYR L+P E
Sbjct: 177 KARGILPESLSYKEAVRGSSVSNVLVAALLKENWELVGEMMVRDVFHHPYRLGLVPHLQE 236
Query: 234 V-RKAGLEAGAYGVTVSGSGPSLFAI 258
V R E AYG +SG+GP++ +
Sbjct: 237 VIRYVKEETEAYGAALSGAGPTMLCL 262
>pir||F81430 homoserine kinase (EC 2.7.1.39) Cj0134 [imported] - Campylobacter
jejuni (strain NCTC 11168) >gi|6967628|emb|CAB72618.1|
(AL139074) homoserine kinase [Campylobacter jejuni]
Length = 292
Score = 102 bits (251), Expect = 6e-21
Identities = 82/285 (28%), Positives = 145/285 (50%), Gaps = 15/285 (5%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEV--EGYD-VPRDENNVAV-I 59
+I PAT AN GPGFD G++++ +E +++S F I + EG D + +NN+ V I
Sbjct: 2 KILVPATSANLGPGFDCLGLSLKL-FNETQIQKSGVFSISIGGEGSDNIFLKKNNIFVNI 60
Query: 60 SAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAAL 119
+ K+ G++ + + + GLGSS A V +A + G ++ I+
Sbjct: 61 FYEIYEKLSGKKDNFRFIFQNNIPLSRGLGSSSAVIVGAIASAYYMSGFKVEKECIL--- 117
Query: 120 EGEKAASGSPHGDNVIPSYYGGF--NILESLNPLRVHR-VDVELNVVVVLPEVEVPTKEA 176
++A H DN+ P+ GGF +++E + + +D +L VVV+P + + T+++
Sbjct: 118 --DEALIYENHPDNIAPATLGGFVCSLVEKNKVYSIKKEIDKDLAAVVVIPNLAMSTEQS 175
Query: 177 RRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRK 236
R+ + + + DA+ NL+ AS L E E + D L R K +P EV+K
Sbjct: 176 RQALAKNLSFNDAVFNLSHASFLTACFLEKKYEFLKFASQDKLHEINRMKNLPELFEVQK 235
Query: 237 AGLEAGAYGVTVSGSGPSLFAIG--ENLKDIGKAMKEKFEELGIR 279
LE A T+SGSG S F++ ++ + K ++ KF++ ++
Sbjct: 236 FALENKALMSTLSGSGSSFFSLAFKDDALALAKKIQTKFKDFRVQ 280
>gb|AAG14699.1|AF293226_1 (AF293226) homoserine kinase [Escherichia coli]
Length = 288
Score = 102 bits (251), Expect = 6e-21
Identities = 76/239 (31%), Positives = 118/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTSLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14687.1|AF293220_1 (AF293220) homoserine kinase [Escherichia coli]
>gi|10186188|gb|AAG14689.1|AF293221_1 (AF293221)
homoserine kinase [Escherichia coli]
>gi|10186191|gb|AAG14691.1|AF293222_1 (AF293222)
homoserine kinase [Escherichia coli]
>gi|10186194|gb|AAG14693.1|AF293223_1 (AF293223)
homoserine kinase [Escherichia coli]
>gi|10186200|gb|AAG14697.1|AF293225_1 (AF293225)
homoserine kinase [Escherichia coli]
Length = 288
Score = 101 bits (249), Expect = 1e-20
Identities = 76/239 (31%), Positives = 118/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14703.1|AF293228_1 (AF293228) homoserine kinase [Escherichia coli]
>gi|10186212|gb|AAG14705.1|AF293229_1 (AF293229)
homoserine kinase [Escherichia coli]
>gi|10186218|gb|AAG14709.1|AF293231_1 (AF293231)
homoserine kinase [Escherichia coli]
>gi|10186221|gb|AAG14711.1|AF293232_1 (AF293232)
homoserine kinase [Escherichia coli]
>gi|10186224|gb|AAG14713.1|AF293233_1 (AF293233)
homoserine kinase [Escherichia coli]
>gi|10186227|gb|AAG14715.1|AF293234_1 (AF293234)
homoserine kinase [Escherichia coli]
>gi|10186230|gb|AAG14717.1|AF293235_1 (AF293235)
homoserine kinase [Escherichia coli]
>gi|10186233|gb|AAG14719.1|AF293236_1 (AF293236)
homoserine kinase [Escherichia coli]
>gi|10186236|gb|AAG14721.1|AF293237_1 (AF293237)
homoserine kinase [Escherichia coli]
>gi|10186239|gb|AAG14723.1|AF293238_1 (AF293238)
homoserine kinase [Escherichia coli]
>gi|10186242|gb|AAG14725.1|AF293239_1 (AF293239)
homoserine kinase [Escherichia coli]
>gi|10186245|gb|AAG14727.1|AF293240_1 (AF293240)
homoserine kinase [Escherichia coli]
>gi|10186248|gb|AAG14729.1|AF293241_1 (AF293241)
homoserine kinase [Escherichia coli]
>gi|10186251|gb|AAG14731.1|AF293242_1 (AF293242)
homoserine kinase [Escherichia coli]
>gi|10186254|gb|AAG14733.1|AF293243_1 (AF293243)
homoserine kinase [Escherichia coli]
>gi|10186257|gb|AAG14735.1|AF293244_1 (AF293244)
homoserine kinase [Escherichia coli]
>gi|10186260|gb|AAG14737.1|AF293245_1 (AF293245)
homoserine kinase [Escherichia coli]
>gi|10186263|gb|AAG14739.1|AF293246_1 (AF293246)
homoserine kinase [Escherichia coli]
>gi|10186266|gb|AAG14741.1|AF293247_1 (AF293247)
homoserine kinase [Escherichia coli]
>gi|10186269|gb|AAG14743.1|AF293248_1 (AF293248)
homoserine kinase [Escherichia coli]
>gi|10186272|gb|AAG14745.1|AF293249_1 (AF293249)
homoserine kinase [Escherichia coli]
>gi|10186275|gb|AAG14747.1|AF293250_1 (AF293250)
homoserine kinase [Escherichia coli]
>gi|10186278|gb|AAG14749.1|AF293251_1 (AF293251)
homoserine kinase [Escherichia coli]
>gi|10186281|gb|AAG14751.1|AF293252_1 (AF293252)
homoserine kinase [Escherichia coli]
>gi|10186284|gb|AAG14753.1|AF293253_1 (AF293253)
homoserine kinase [Escherichia coli]
>gi|10186287|gb|AAG14755.1|AF293254_1 (AF293254)
homoserine kinase [Escherichia coli]
>gi|10186290|gb|AAG14757.1|AF293255_1 (AF293255)
homoserine kinase [Escherichia coli]
>gi|10186293|gb|AAG14759.1|AF293256_1 (AF293256)
homoserine kinase [Escherichia coli]
>gi|10186296|gb|AAG14761.1|AF293257_1 (AF293257)
homoserine kinase [Escherichia coli]
>gi|10186299|gb|AAG14763.1|AF293258_1 (AF293258)
homoserine kinase [Escherichia coli]
>gi|10186311|gb|AAG14771.1|AF293262_1 (AF293262)
homoserine kinase [Escherichia coli]
>gi|10186314|gb|AAG14773.1|AF293263_1 (AF293263)
homoserine kinase [Escherichia coli]
>gi|10186317|gb|AAG14775.1|AF293264_1 (AF293264)
homoserine kinase [Escherichia coli]
Length = 288
Score = 101 bits (249), Expect = 1e-20
Identities = 76/239 (31%), Positives = 118/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14765.1|AF293259_1 (AF293259) homoserine kinase [Escherichia coli]
Length = 288
Score = 101 bits (249), Expect = 1e-20
Identities = 76/239 (31%), Positives = 118/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGLDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14779.1|AF293266_1 (AF293266) homoserine kinase [Escherichia coli]
Length = 288
Score = 101 bits (249), Expect = 1e-20
Identities = 76/239 (31%), Positives = 118/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14701.1|AF293227_1 (AF293227) homoserine kinase [Escherichia coli]
Length = 288
Score = 101 bits (248), Expect = 1e-20
Identities = 78/239 (32%), Positives = 119/239 (49%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGY---DVPRDENNVAVISAKALFKM-VGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G +P + V F + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCLELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14767.1|AF293260_1 (AF293260) homoserine kinase [Escherichia coli]
>gi|10186308|gb|AAG14769.1|AF293261_1 (AF293261)
homoserine kinase [Escherichia coli]
Length = 288
Score = 101 bits (248), Expect = 1e-20
Identities = 77/239 (32%), Positives = 120/239 (49%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGY---DVPRDE-NNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G +P + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPWENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAA83915.1| (J01706) homoserine kinase [Escherichia coli]
>gi|216436|dbj|BAA01287.1| (D10483) homoserine kinase
[Escherichia coli]
Length = 309
Score = 100 bits (247), Expect = 2e-20
Identities = 79/268 (29%), Positives = 128/268 (47%), Gaps = 15/268 (5%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEP-----GDEVIVKESDSFEIEVEGYDVPR----DEN 54
++YAPA+ AN GFDV G A+ GD V V+ + +F + G +
Sbjct: 3 KVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAQTFSLNNLGRFADKLPSEPRE 62
Query: 55 NVAVISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGV---DND 111
N+ + + +G++ V + L+K + SGLGSS S VA +A G D
Sbjct: 63 NIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTR 122
Query: 112 ELIIMAALEGEKAASGSPHGDNVIPSYYGGFNILESLNPLRVHRVDVELNVVVVLPEVEV 171
L +M LEG SGS H DNV P + GG ++ N + +V ++ +
Sbjct: 123 LLALMGELEGR--ISGSIHYDNVAPCFLGGMQLMIEENDIISQQVQGLMSGCGCSRIRGL 180
Query: 172 PTKEARR-IVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPW 230
++ ++ +P + +D I + + + A E +L+ D +A PYR++L+P
Sbjct: 181 KSRRQKQGYLPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPG 240
Query: 231 FDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
F + R+A E GA +SGSGP+LFA+
Sbjct: 241 FRQARQAVAEIGAVASGISGSGPTLFAL 268
>gb|AAG14707.1|AF293230_1 (AF293230) homoserine kinase [Escherichia coli]
Length = 288
Score = 100 bits (247), Expect = 2e-20
Identities = 76/239 (31%), Positives = 118/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFGLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14777.1|AF293265_1 (AF293265) homoserine kinase [Escherichia coli]
Length = 288
Score = 100 bits (247), Expect = 2e-20
Identities = 76/239 (31%), Positives = 117/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAANLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>gb|AAG14675.1|AF293214_1 (AF293214) homoserine kinase [Escherichia coli]
>gi|10186170|gb|AAG14677.1|AF293215_1 (AF293215)
homoserine kinase [Escherichia coli]
>gi|10186173|gb|AAG14679.1|AF293216_1 (AF293216)
homoserine kinase [Escherichia coli]
>gi|10186176|gb|AAG14681.1|AF293217_1 (AF293217)
homoserine kinase [Escherichia coli]
>gi|10186179|gb|AAG14683.1|AF293218_1 (AF293218)
homoserine kinase [Escherichia coli]
>gi|10186182|gb|AAG14685.1|AF293219_1 (AF293219)
homoserine kinase [Escherichia coli]
Length = 288
Score = 100 bits (246), Expect = 2e-20
Identities = 76/239 (31%), Positives = 118/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGLGSS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVVSGISGSGPTLFAL 247
>pir||C71940 homoserine kinase - Helicobacter pylori (strain J99)
>gi|4154901|gb|AAD05950.1| (AE001472) HOMOSERINE KINASE
[Helicobacter pylori J99]
Length = 293
Score = 99.5 bits (244), Expect = 4e-20
Identities = 77/283 (27%), Positives = 138/283 (48%), Gaps = 16/283 (5%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEV--EGYDVPRD-ENNVAVISA 61
+ PAT AN GPGFD G+++ + ++ S+ +++ EG +P+ NN+
Sbjct: 3 VSVPATSANLGPGFDCLGLSLNLR-NRFFIEPSNIHAVKLVGEGEGIPKFLTNNIFTKVF 61
Query: 62 KALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDND-ELIIMAALE 120
+ K G +G K L V G+GSS A V +A LG D E I+ AL
Sbjct: 62 YEILKKHGNDGSFKFLLHNKVPITRGMGSSSAMIVGAVASAFAFLGFAFDRENILNTALI 121
Query: 121 GEKAASGSPHGDNVIPSYYGGFN--ILESLNPLRVH-RVDVELNVVVVLPEVEVPTKEAR 177
E H DN+ P+ +GG+N +E + + ++ L V+V+P + TK++R
Sbjct: 122 YEN------HPDNITPAVFGGYNAAFVEKKKVISLKTKIPSFLKAVMVIPNRVISTKQSR 175
Query: 178 RIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKA 237
++P++ +++++ NL+ AS + +A+ +G + + D + R + P ++K
Sbjct: 176 HLLPKRYSVQESVFNLSHASLMTMAIVQGKWDLLRCCSKDRMHQYKRMQTYPVLFAIQKL 235
Query: 238 GLEAGAYGVTVSGSGPSLF--AIGENLKDIGKAMKEKFEELGI 278
LE A T+SGSG S F E+ + + + +KF + +
Sbjct: 236 ALENNALMSTLSGSGSSFFNMCYEEDAPKLKQVLSKKFPKFRV 278
>gb|AAG14695.1|AF293224_1 (AF293224) homoserine kinase [Escherichia coli]
Length = 288
Score = 99.1 bits (243), Expect = 6e-20
Identities = 75/239 (31%), Positives = 117/239 (48%), Gaps = 11/239 (4%)
Query: 29 GDEVIVKESDSFEIEVEGYDVPR----DENNVAVISAKALFKMVGEEGGVKIRLKKGVRP 84
GD V V+ +++F + G + N+ + + +G++ V + L+K +
Sbjct: 11 GDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPI 70
Query: 85 KSGLGSSGASSVAGALAAARVLGV---DNDELIIMAALEGEKAASGSPHGDNVIPSYYGG 141
SGL SS S VA +A G D L +M LEG SGS H DNV P + GG
Sbjct: 71 GSGLSSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGR--ISGSIHYDNVAPCFLGG 128
Query: 142 FNILESLNPLRVHRVDV--ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSL 199
++ N + +V E V+ P ++V T EAR I+P + +D I + +
Sbjct: 129 MQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGF 188
Query: 200 VLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKAGLEAGAYGVTVSGSGPSLFAI 258
+ A E +L+ D +A PYR++L+P F + R+A E GA +SGSGP+LFA+
Sbjct: 189 IHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFAL 247
>pir||F72364 hypothetical protein TM0545 - Thermotoga maritima (strain MSB8)
>gi|4981059|gb|AAD35630.1|AE001729_10 (AE001729)
homoserine kinase, putative [Thermotoga maritima]
Length = 281
Score = 91.7 bits (224), Expect = 9e-18
Identities = 75/258 (29%), Positives = 124/258 (47%), Gaps = 14/258 (5%)
Query: 4 RIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEG-YDVPRDENNVAVISAK 62
++ PAT N G GFDVFG+A++ + ++ IE G Y ++N+ +
Sbjct: 2 KVLVPATTTNLGAGFDVFGLALDLFNEVEFSFDTKETTIESTGKYASDLKDHNLFFEVLR 61
Query: 63 ALFKMVGEE-GGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLG--VDNDELIIMAA- 118
+ G V+I+ + SGLGSS A VA A G + ++L+ +A
Sbjct: 62 FFERKTGYRVPPVRIKQTCNIPVSSGLGSSAAVIVAALHIANEGTGRNLSREDLMKLAVE 121
Query: 119 LEGEKAASGSPHGDNVIPSYYGGFNIL-ESLNPLRVHRVDVELNVVVVLPEVEVPTKEAR 177
LEG H DNV+P++ GG + ++ + L + +++L++ ++P V T E R
Sbjct: 122 LEG--------HPDNVVPAFTGGLVVCYQNGSHLDFEKFEIDLSLTFLVPNFPVCTNEMR 173
Query: 178 RIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDEVRKA 237
+I+PEKVP +DA+ N+ + + + G I+ + + D L YR E +A
Sbjct: 174 KILPEKVPFEDAVFNIKNSCQFLAKIAAGKIKEALKYVGDRLHQNYRINGNKKMKEFVEA 233
Query: 238 GLEAGAYGVTVSGSGPSL 255
L VSGSGPS+
Sbjct: 234 ILSKNPEYWFVSGSGPSV 251
>emb|CAC18626.1| (AL451109) probable homoserine kinase [Neurospora crassa]
Length = 358
Score = 89.7 bits (219), Expect = 4e-17
Identities = 91/336 (27%), Positives = 145/336 (43%), Gaps = 69/336 (20%)
Query: 5 IYAPATIANFGPGFDVFGMAIEEPGD-EVIVKESDSFE-------IEVEGY---DVPRDE 53
I P + AN GPGFDV G+A+ + V + S + I EG D+ D
Sbjct: 12 IKTPCSSANIGPGFDVIGLALSMYLELHVTIDRSKTTSDKPLNCRITYEGQGEEDISLDP 71
Query: 54 NNVAVISAKALFKMVGEEGG-----VKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGV 108
V +I+ AL+ + + + +K + GLGSSGA+ VAG V G+
Sbjct: 72 E-VNLITRVALYVLRCNDQRSFPVETHVHIKNPIPLGRGLGSSGAAVVAGVQLGKEVGGL 130
Query: 109 DN--DELIIMAALEGEKAASGSPHGDNVIPSYYGGF--NILESLNPLRVHRVDV------ 158
+ E + L E+ H DNV + +GGF L+ L P R ++
Sbjct: 131 HDLTPERLFDYCLMIER------HPDNVGAALFGGFVGTYLKPLTPEETARTEIPLSEVL 184
Query: 159 ------------------------------ELNVVVVLPEVEVPTKEARRIVPEKVPLKD 188
E+ V ++PE EVPT +AR ++P + P D
Sbjct: 185 PAPAGGVDTGVKPPSPPHGIGHHIKFPWAPEIKAVAIIPEFEVPTAKAREVLPAEYPRAD 244
Query: 189 AIKNLAMASSLVLALKEG--DIETVGRLLDDNLALPYRKKLMPWFDEVRKA---GLEAGA 243
NL + L +AL + D E + + D L PYR+ L+P ++ ++ + G
Sbjct: 245 VTFNLQRIALLPVALGQSPPDPELINLAMQDKLHQPYRQVLIPGLTKIVESMTPATQPGL 304
Query: 244 YGVTVSGSGPSLFAIG-ENLKDIGKAMKEKFEELGI 278
GV +SG+GP++ A+ EN + I + + E+F+ I
Sbjct: 305 LGVCLSGAGPTILALATENFETIAQKIIEEFKSNNI 340
>pir||T40495 homoserine kinase - fission yeast (Schizosaccharomyces pombe)
>gi|2832883|emb|CAA16824.1| (AL021730) homoserine kinase
[Schizosaccharomyces pombe]
Length = 338
Score = 89.7 bits (219), Expect = 4e-17
Identities = 85/328 (25%), Positives = 138/328 (41%), Gaps = 50/328 (15%)
Query: 2 KKRIYAPATIANFGPGFDVFGMAIEE--PGDEVIVKESDSFEIEVEG-------YDVPRD 52
K +I PA+ AN GPGFDV GM++EE D + ES + EG DV ++
Sbjct: 3 KFQIKVPASSANIGPGFDVLGMSLEEYMTLDVEVSTESGPCVLTYEGDGKEHVSLDVQKN 62
Query: 53 ENNVAVISAKALFKMVGEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDE 112
+ + KI + + G+GSSG++++AG + A + + +
Sbjct: 63 MITQTSLYVLRCNNISTFPYATKIHVINPIPLGRGMGSSGSAAIAGVMLANEIAKLGLSK 122
Query: 113 LIIMAALEGEKAASGSPHGDNVIPSYYGGF--NILESL-----NPLRVHRVDV------- 158
L +M + H DNV+ S GGF + L L N D+
Sbjct: 123 LQMM-----DYVLMIERHPDNVMASMMGGFVGSFLRELSEEEKNAFSPSADDLLKNEALT 177
Query: 159 ----------------ELNVVVVLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLA 202
EL +VV+PE + T +AR ++P D + NL + L A
Sbjct: 178 LPPKSLGTFARLPWASELKAIVVIPEFHLATSKARSVLPTSYGRTDVVYNLQRLALLTTA 237
Query: 203 LKEGDI--ETVGRLLDDNLALPYRKKLMPWFDEV---RKAGLEAGAYGVTVSGSGPSLFA 257
L + I V ++ D + PYR L+P + + G G+ +SG+GP++ A
Sbjct: 238 LGQTPINPHLVYEVMKDKVHQPYRASLIPGLQNILATLNPDTQPGLCGICLSGAGPTVLA 297
Query: 258 IGE-NLKDIGKAMKEKFEELGIRAEFWI 284
+ N +I AM FE+ G++ + +
Sbjct: 298 LATGNFDEIAHAMLSIFEKHGVKCRYLV 325
>sp|P45836|KHSE_MYCLE HOMOSERINE KINASE (HK) >gi|7434440|pir||T09990 homoserine kinase
(EC 2.7.1.39) - Mycobacterium leprae
>gi|699339|gb|AAA63100.1| (U15186) homoserine kinase
[Mycobacterium leprae]
Length = 314
Score = 83.1 bits (202), Expect = 4e-15
Identities = 79/265 (29%), Positives = 125/265 (46%), Gaps = 22/265 (8%)
Query: 9 ATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEV---EGYD-VPRDENNVAVISAKAL 64
A+ AN GPGFD G+A+ DE++V+ +DS + V EG D VP ++ V + +
Sbjct: 17 ASSANLGPGFDSIGLALSLC-DEIVVETTDSGLVVVVDGEGADQVPMGPEHLVVRAVRRG 75
Query: 65 FKMVG-EEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALEGEK 123
+ VG G+ +R + + GLGSS A++V G LA D + A +
Sbjct: 76 LQAVGVSAAGLVVRCRNAIPHSRGLGSS-AAAVVGGLAVVNGFVAQIDSTPLSNAQLIQL 134
Query: 124 AASGSPHGDNVIPSYYGGFNIL----------ESLNPLRVHRVDVELNVVVVLPEVEVPT 173
A+ H DN + GG + PLR+H ++++ +PE T
Sbjct: 135 ASEFEGHPDNAAAAVLGGAVVSWVDRSYDQPDYCAVPLRLHP---DIHLFAAIPEERSST 191
Query: 174 KEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDE 233
E+R ++P +V DA N++ A+ LV+AL E + + +D L P+R M E
Sbjct: 192 AESRVLLPARVSHDDARFNVSRAALLVVALTERP-DLLMAATEDVLHQPHRASAMSASAE 250
Query: 234 VRKAGLEAGAYGVTVSGSGPSLFAI 258
+ L T+SG+GPSL A+
Sbjct: 251 YLRL-LRRHNVAATLSGAGPSLIAL 274
>sp|P07128|KHSE_BRELA HOMOSERINE KINASE (HK) >gi|39588|emb|CAA68332.1| (Y00140)
homoserine kinase (AA 1-309) [Corynebacterium
glutamicum]
Length = 309
Score = 81.5 bits (198), Expect = 1e-14
Identities = 75/299 (25%), Positives = 137/299 (45%), Gaps = 37/299 (12%)
Query: 2 KKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGY---DVPRDENNVAV 58
K + P + AN GPGFD G+A+ + E+EV G +VP D +++ V
Sbjct: 10 KVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEVPLDGSHLVV 69
Query: 59 ISAKALFKMV-GEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARV--LGVDNDELI- 114
+ +A K E G+++ + GLGSS A++VAG AA + + ++++
Sbjct: 70 KAIRAGLKAADAEVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADFPLTQEQIVQ 129
Query: 115 IMAALEGEKAASGSPHGDNVIPSYYGGFNI------LESLNPLRVHRVDVE----LNVVV 164
+ +A EG H DN S GG + ++ + + V +E +
Sbjct: 130 LSSAFEG--------HPDNAAASVLGGAVVSWTNLSIDGKSQPQYAAVPLEVQDNIRATA 181
Query: 165 VLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYR 224
++P T+ RR++P +V DA N++ + +++AL++ + + D L PYR
Sbjct: 182 LVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRP-DLLWEGTRDRLHQPYR 240
Query: 225 KKLMP----WFDEVRKAGLEAGAYGVTVSGSGPSLFAIGENLKDIGKAMKEKFEELGIR 279
+++P W + +R G Y +SG+GP+ + + + I + E E GI+
Sbjct: 241 AEVLPVTSEWVNRLRNRG-----YAAYLSGAGPTAMVL--STEPIPDKVLEDARESGIK 292
>sp|P08210|KHSE_CORGL HOMOSERINE KINASE (HK) >gi|66855|pir||KIFKMG homoserine kinase (EC
2.7.1.39) - Corynebacterium glutamicum
>gi|40504|emb|CAA68615.1| (Y00546) homoserine kinase
(HK) (AA 1-309) [Corynebacterium glutamicum]
Length = 309
Score = 81.5 bits (198), Expect = 1e-14
Identities = 75/299 (25%), Positives = 137/299 (45%), Gaps = 37/299 (12%)
Query: 2 KKRIYAPATIANFGPGFDVFGMAIEEPGDEVIVKESDSFEIEVEGY---DVPRDENNVAV 58
K + P + AN GPGFD G+A+ + E+EV G +VP D +++ V
Sbjct: 10 KVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEVPLDGSHLVV 69
Query: 59 ISAKALFKMV-GEEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARV--LGVDNDELI- 114
+ +A K E G+++ + GLGSS A++VAG AA + + ++++
Sbjct: 70 KAIRAGLKAADAEVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADFPLTQEQIVQ 129
Query: 115 IMAALEGEKAASGSPHGDNVIPSYYGGFNI------LESLNPLRVHRVDVE----LNVVV 164
+ +A EG H DN S GG + ++ + + V +E +
Sbjct: 130 LSSAFEG--------HPDNAAASVLGGAVVSWTNLSIDGKSQPQYAAVPLEVQDNIRATA 181
Query: 165 VLPEVEVPTKEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYR 224
++P T+ RR++P +V DA N++ + +++AL++ + + D L PYR
Sbjct: 182 LVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRP-DLLWEGTRDRLHQPYR 240
Query: 225 KKLMP----WFDEVRKAGLEAGAYGVTVSGSGPSLFAIGENLKDIGKAMKEKFEELGIR 279
+++P W + +R G Y +SG+GP+ + + + I + E E GI+
Sbjct: 241 AEVLPITSEWVNRLRNRG-----YAAYLSGAGPTAMVL--STEPIPDKVLEDARESGIK 292
>sp|Q10603|KHSE_MYCTU HOMOSERINE KINASE (HK) >gi|7434439|pir||D70773 probable thrB
protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1322420|emb|CAA97729.1| (Z73419) thrB [Mycobacterium
tuberculosis]
Length = 316
Score = 79.2 bits (192), Expect = 5e-14
Identities = 86/302 (28%), Positives = 133/302 (43%), Gaps = 29/302 (9%)
Query: 9 ATIANFGPGFDVFGMAIEEPGDEVIVKESDS---FEIEVEGYD-VPRDENNVAVISAKAL 64
A+ AN GPGFD G+A+ DE+IV+ +DS ++ EG D VP ++ V + +
Sbjct: 19 ASSANLGPGFDSVGLAL-SLYDEIIVETTDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHG 77
Query: 65 FKMVG-EEGGVKIRLKKGVRPKSGLGSSGASSVAGALAAARVLGVDNDELIIMAALEGEK 123
+ G G+ +R + + GLGSS A++V G LAA L V D A +
Sbjct: 78 LQAAGVSAAGLAVRCRNAIPHSRGLGSS-AAAVVGGLAAVNGLVVQTDSSPSSDAELIQL 136
Query: 124 AASGSPHGDNVIPSYYGGFNIL----------ESLNPLRVHRVDVELNVVVVLPEVEVPT 173
A+ H DN + GG + S LR+H ++ + +PE T
Sbjct: 137 ASEFEGHPDNAAAAVLGGAVVSWTDHSGDRPNYSAVSLRLH---PDIRLFTAIPEQRSST 193
Query: 174 KEARRIVPEKVPLKDAIKNLAMASSLVLALKEGDIETVGRLLDDNLALPYRKKLMPWFDE 233
E R ++P +V DA N++ A+ LV+AL E + + +D L P R M E
Sbjct: 194 AETRVLLPAQVSHDDARFNVSRAALLVVALTERP-DLLMAATEDLLHQPQRAAAMTASAE 252
Query: 234 VRKAGLEAGAYGVTVSGSGPSLFAIGENLKDIGKAMKEKFEELGIRAEFWITK--TGRGA 291
+ L +SG+GPSL A+ + + E G F +T+ G
Sbjct: 253 YLRL-LRRHNVAAALSGAGPSLIALSTD-----SELPTDAVEFGAAKGFAVTELTVGEAV 306
Query: 292 KW 293
+W
Sbjct: 307 RW 308
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.315 0.137 0.386
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 110144292
Number of Sequences: 2977
Number of extensions: 4840144
Number of successful extensions: 10133
Number of sequences better than 1.0e-10: 46
Number of HSP's better than 0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 10010
Number of HSP's gapped (non-prelim): 48
length of query: 294
length of database: 189,106,746
effective HSP length: 57
effective length of query: 237
effective length of database: 154,992,987
effective search space: 36733337919
effective search space used: 36733337919
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 165 (68.7 bits)