BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1677 (thrC-1) DE:threonine synthase (thrC-2)
(394 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75080 threonine synthase (EC 4.2.99.2) thrc-2 PAB1677 [sim... 789 0.0
pir||E71136 threonine synthase (EC 4.2.99.2) PH0857 [similarity]... 693 0.0
sp|Q58860|THRC_METJA PROBABLE THREONINE SYNTHASE >gi|2118306|pir... 496 e-139
gi|11498914 threonine synthase (thrC-2) [Archaeoglobus fulgidus]... 472 e-132
pir||G69131 threonine synthase (EC 4.2.99.2) - Methanobacterium ... 440 e-122
gb|AAK41164.1| Threonine synthase (thrC-2) [Sulfolobus solfatari... 383 e-105
pir||G72364 threonine synthase (EC 4.2.99.2) TM0546 [similarity]... 381 e-105
pir||H70338 threonine synthase (EC 4.2.99.2) - Aquifex aeolicus ... 370 e-101
pir||B72455 threonine synthase (EC 4.2.99.2) APE2286 [similarity... 356 3e-97
sp|P74193|THRC_SYNY3 THREONINE SYNTHASE >gi|7436917|pir||S75823 ... 344 1e-93
sp|P09123|THRC_BRELA THREONINE SYNTHASE >gi|68321|pir||DWFKTG th... 341 7e-93
sp|Q10610|THRC_MYCTU PROBABLE THREONINE SYNTHASE >gi|7436919|pir... 336 2e-91
gb|AAG20514.1| (AE005123) threonine synthase; ThrC1 [Halobacteri... 335 5e-91
dbj|BAB07140.1| (AP001518) threonine synthase [Bacillus halodurans] 330 2e-89
sp|P04990|THRC_BACSU THREONINE SYNTHASE >gi|80429|pir||A25364 th... 327 2e-88
sp|P45837|THRC_MYCLE PROBABLE THREONINE SYNTHASE >gi|7436934|pir... 321 7e-87
pir||D70354 threonine synthase (EC 4.2.99.2) thrC1 [similarity] ... 282 4e-75
gi|11498161 threonine synthase (thrC-1) [Archaeoglobus fulgidus]... 263 2e-69
pir||S77200 threonine synthase (EC 4.2.99.2) 1 - Synechocystis s... 252 7e-66
pir||H71013 probable threonine synthase (EC 4.2.99.2) PH1406 [si... 245 5e-64
pir||E75118 probable threonine synthase (EC 4.2.99.2) thrc-2 PAB... 245 6e-64
pir||S71362 threonine synthase (EC 4.2.99.2) precursor - Arabido... 242 4e-63
pir||T08545 threonine synthase (EC 4.2.99.2) precursor - Arabido... 242 4e-63
gb|AAF74984.1|AF082894_1 (AF082894) threonine synthase [Solanum ... 240 2e-62
gb|AAG19064.1| (AE005005) threonine synthase; ThrC2 [Halobacteri... 233 2e-60
gb|AAD55628.1|AC008017_1 (AC008017) Putative threonine synthase ... 231 1e-59
emb|CAB93053.1| (AL357432) putative threonine synthase [Streptom... 229 3e-59
pir||C71042 probable threonine synthase (EC 4.2.99.2) PH1627 [si... 180 3e-44
gb|AAB40316.1| (U46200) threonine synthase [Cloning vector pDG16... 176 3e-43
pir||E75172 probable threonine synthase (EC 4.2.99.2) thrc-2 PAB... 173 4e-42
gb|AAK40813.1| Threonine synthase (thrC-1) [Sulfolobus solfatari... 171 1e-41
gb|AAB40319.1| (U46200) threonine synthase [Cloning vector pDG16... 154 1e-36
gb|AAG20250.1| (AE005100) threonine synthase; ThrC3 [Halobacteri... 153 4e-36
emb|CAC11175.1| (AL445063) threonine synthase related protein [T... 146 3e-34
emb|CAC11637.1| (AL445064) threonine synthase related protein [T... 143 4e-33
gb|AAB40334.1| (U46202) threonine synthase [Cloning vector pDG17... 115 1e-24
pir||H72628 probable threonine synthase (EC 4.2.99.2) APE1488 [s... 113 5e-24
pir||D81355 threonine dehydratase (EC 4.2.1.16) Cj0828c [importe... 100 4e-20
gb|AAA72079.1| (M34778) ORF; similar to threonine synthases [Met... 98 2e-19
sp|P05792|THD2_ECOLI THREONINE DEHYDRATASE CATABOLIC (THREONINE ... 90 4e-17
pir||D72386 threonine dehydratase (EC 4.2.1.16) TM0356 [similari... 89 7e-17
gb|AAG20244.1| (AE005099) threonine dehydratase; IluA [Halobacte... 86 8e-16
pir||DWRTT L-serine dehydratase (EC 4.2.1.13) - rat >gi|57225|em... 84 3e-15
sp|P44503|THRC_HAEIN THREONINE SYNTHASE >gi|1075349|pir||H64047 ... 81 3e-14
gi|11345492 serine racemase [Homo sapiens] >gi|10434972|dbj|BAB1... 80 3e-14
gb|AAK40587.1| Threonine dehydratase catabolic (threonine deamin... 80 6e-14
emb|CAC11260.1| (AL445063) probable threonine dehydratase, biode... 79 1e-13
pir||T04211 probable threonine dehydratase (EC 4.2.1.16) T5C23.7... 78 2e-13
gb|AAF54364.1| (AE003682) CG8129 gene product [alt 1] [Drosophil... 78 2e-13
pir||C72630 probable threonine dehydratase APE1498 - Aeropyrum p... 77 3e-13
pir||B82634 threonine dehydratase catabolic XF1819 [imported] - ... 77 4e-13
gi|7305521 serine racemase [Mus musculus] >gi|6448865|gb|AAF0870... 76 9e-13
sp|Q02145|THD1_LACLA THREONINE DEHYDRATASE BIOSYNTHETIC (THREONI... 75 2e-12
pir||F82086 threonine synthase VC2362 [imported] - Vibrio choler... 75 2e-12
sp|P57289|THRC_BUCAI THREONINE SYNTHASE >gi|10038874|dbj|BAB1290... 74 3e-12
gi|5803161 serine dehydratase [Homo sapiens] >gi|134386|sp|P2013... 73 4e-12
gb|AAA67575.1| (M87049) threonine deaminase [Escherichia coli] 73 7e-12
gb|AAB81922.1| (U92974) IlvA [Lactococcus lactis] 73 7e-12
gb|AAA24014.1| (K03503) threonine dehydratase [Escherichia coli] 72 1e-11
gb|AAA24024.1| (M32253) ilvA [Escherichia coli] 72 1e-11
sp|Q10766|THD1_MYCTU PROBABLE THREONINE DEHYDRATASE BIOSYNTHETIC... 72 1e-11
sp|Q04513|THD1_CORGL THREONINE DEHYDRATASE BIOSYNTHETIC (THREONI... 71 2e-11
emb|CAB39589.1| (AL049478) putative threonine dehydratase biosyn... 71 2e-11
sp|P46493|THD1_HAEIN THREONINE DEHYDRATASE BIOSYNTHETIC (THREONI... 70 4e-11
gb|AAF33479.1| (AF233324) S. typhimurium threonine deaminase (IL... 70 4e-11
gi|6322631 Pyridoxal-5'phosphate-dependent enzyme homologous to ... 70 5e-11
pir||T36434 threonine dehydratase (EC 4.2.1.16) SCF43A.11c [simi... 70 5e-11
sp|P04968|THD1_ECOLI THREONINE DEHYDRATASE BIOSYNTHETIC (THREONI... 69 6e-11
sp|P53607|THD1_BURCE THREONINE DEHYDRATASE BIOSYNTHETIC (THREONI... 69 6e-11
sp|Q60179|TRPB_METJA TRYPTOPHAN SYNTHASE BETA CHAIN >gi|2118310|... 69 6e-11
pir||E75502 threonine dehydratase (EC 4.2.1.16) DR0567 [similari... 69 6e-11
>pir||G75080 threonine synthase (EC 4.2.99.2) thrc-2 PAB1677 [similarity] -
Pyrococcus abyssi (strain Orsay)
>gi|5458460|emb|CAB49948.1| (AJ248286) threonine
synthase (thrC-2) [Pyrococcus abyssi]
Length = 394
Score = 789 bits (2015), Expect = 0.0
Identities = 394/394 (100%), Positives = 394/394 (100%)
Query: 1 MVLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKI 60
MVLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKI
Sbjct: 1 MVLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKI 60
Query: 61 VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVAC 120
VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVAC
Sbjct: 61 VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVAC 120
Query: 121 ASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVI 180
ASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVI
Sbjct: 121 ASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVI 180
Query: 181 EASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKEL 240
EASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKEL
Sbjct: 181 EASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKEL 240
Query: 241 YEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRA 300
YEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRA
Sbjct: 241 YEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRA 300
Query: 301 VEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLV 360
VEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLV
Sbjct: 301 VEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLV 360
Query: 361 TTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVIE 394
TTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVIE
Sbjct: 361 TTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVIE 394
>pir||E71136 threonine synthase (EC 4.2.99.2) PH0857 [similarity] - Pyrococcus
horikoshii >gi|3257268|dbj|BAA29951.1| (AP000003) 394aa
long hypothetical threonine synthase [Pyrococcus
horikoshii]
Length = 394
Score = 693 bits (1769), Expect = 0.0
Identities = 332/394 (84%), Positives = 373/394 (94%)
Query: 1 MVLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKI 60
MVLRC+ CGREYPEDE+RYRC+CGGLLEVV+DLDKVDT IF+G +I LWKYESWLPVKK
Sbjct: 1 MVLRCVVCGREYPEDEVRYRCDCGGLLEVVIDLDKVDTSIFNGRDIKLWKYESWLPVKKR 60
Query: 61 VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVAC 120
VSL EGGTPLYRL+NLE L VKELYAKNEGANPTGSFKDRGMTVGVSKALELGM +V C
Sbjct: 61 VSLEEGGTPLYRLSNLENELKVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMDKVIC 120
Query: 121 ASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVI 180
ASTGNTSASLAAYAAKAGI+AYVL+PSGKIALGKLAQAII+GAKVIPIKGNFDDALR+V+
Sbjct: 121 ASTGNTSASLAAYAAKAGIKAYVLIPSGKIALGKLAQAIIHGAKVIPIKGNFDDALRIVV 180
Query: 181 EASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKEL 240
EAS ELGIYMLNSINPFRLEGQKTIAYEIYDQL KVPDN++LPVGNAGNISAIWKGFKE+
Sbjct: 181 EASRELGIYMLNSINPFRLEGQKTIAYEIYDQLGKVPDNIILPVGNAGNISAIWKGFKEM 240
Query: 241 YEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRA 300
YEAGVID+LPRMIGIQAEGASPL KAWKEK+KF+PE+NPET+A+AIRIGNPANW KAW+A
Sbjct: 241 YEAGVIDELPRMIGIQAEGASPLVKAWKEKKKFQPEENPETVASAIRIGNPANWIKAWKA 300
Query: 301 VEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLV 360
VEESGG+FE VSDEEIL+AQR+LAS+EGLFVEPASAASLAGLIKLL ++ R+ES++L+
Sbjct: 301 VEESGGLFESVSDEEILRAQRLLASREGLFVEPASAASLAGLIKLLESGEISRNESYILI 360
Query: 361 TTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVIE 394
TTGHGLKDP+IV++NF++PEPIEPTL+AF+ VI+
Sbjct: 361 TTGHGLKDPNIVIKNFQIPEPIEPTLEAFKEVIK 394
>sp|Q58860|THRC_METJA PROBABLE THREONINE SYNTHASE >gi|2118306|pir||H64482 threonine
synthase (EC 4.2.99.2) - Methanococcus jannaschii
>gi|1592106|gb|AAB99473.1| (U67587) threonine synthase
(thrC) [Methanococcus jannaschii]
Length = 405
Score = 496 bits (1263), Expect = e-139
Identities = 251/403 (62%), Positives = 316/403 (78%), Gaps = 9/403 (2%)
Query: 1 MVLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGN----NITLWKYESWLP 56
M+ RCI+CG+ Y DEI Y CECGGLLE++ D +++ K+ + I +W+Y +LP
Sbjct: 1 MLQRCIKCGKTYDVDEIIYTCECGGLLEIIYDYEEIKDKVSEEKLRKREIGVWRYLEYLP 60
Query: 57 VK---KIVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALEL 113
VK KIVSL EGGTPLYR NNLEK LG+KELY KNEGANPTGSFKDRGMTVGV++A EL
Sbjct: 61 VKDESKIVSLCEGGTPLYRCNNLEKELGIKELYVKNEGANPTGSFKDRGMTVGVTRANEL 120
Query: 114 GMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFD 173
G++ V CASTGNTSASLAAY+A++G + VL+P GK+ALGKLAQA+ YGAKVI +KGNFD
Sbjct: 121 GVEVVGCASTGNTSASLAAYSARSGKKCIVLLPEGKVALGKLAQAMFYGAKVIQVKGNFD 180
Query: 174 DALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVGNAGNISA 232
DAL +V + ++E IY+LNSINPFRLEGQKTIA+EI DQL +VPD V++PVGNAGNISA
Sbjct: 181 DALDMVKQLAKEKLIYLLNSINPFRLEGQKTIAFEICDQLNWQVPDRVIVPVGNAGNISA 240
Query: 233 IWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRK-FKPEKNPETLATAIRIGNP 291
IWKGFKE G+ID+LP+M GIQA+GA P+ +A++++ K P KNPET+ATAIRIGNP
Sbjct: 241 IWKGFKEFEITGIIDELPKMTGIQADGAKPIVEAFRKRAKDIIPYKNPETIATAIRIGNP 300
Query: 292 ANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKV 351
N KA A+ SGG E V+DEEI++AQ++LA KEG+FVEPASA+S+AGL KLL E +
Sbjct: 301 VNAPKALDAIYSSGGYAEAVTDEEIVEAQKLLARKEGIFVEPASASSIAGLKKLLEEGII 360
Query: 352 DRDESFVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVIE 394
DRDE V +TTGHGLKDPD +R + P IE ++ +R+++
Sbjct: 361 DRDERIVCITTGHGLKDPDAAIRASEEPIKIECDMNVLKRILK 403
>gi|11498914 threonine synthase (thrC-2) [Archaeoglobus fulgidus]
>gi|7436916|pir||C69414 threonine synthase (EC 4.2.99.2)
thrC-2 AF1316 [similarity] - Archaeoglobus fulgidus
>gi|2649262|gb|AAB89930.1| (AE001013) threonine synthase
(thrC-2) [Archaeoglobus fulgidus]
Length = 396
Score = 472 bits (1202), Expect = e-132
Identities = 245/394 (62%), Positives = 308/394 (77%), Gaps = 6/394 (1%)
Query: 3 LRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKI-FDGNNITLWKYESWLPVK-KI 60
L+CI CG+E+ ++ Y CECGGLLEV +DLD+V+ DG+NIT+WKY S LPVK
Sbjct: 4 LKCIECGKEWGDEN--YTCECGGLLEVEIDLDEVEIDFRLDGSNITVWKYRSLLPVKIDP 61
Query: 61 VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVAC 120
V+L EGGTPLYR LEK +GV+ +Y K+EG NP+GSFKDRGMTVGV+KALELG K VAC
Sbjct: 62 VTLKEGGTPLYRAERLEKEVGVRRVYVKHEGLNPSGSFKDRGMTVGVTKALELGRKAVAC 121
Query: 121 ASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVI 180
ASTGNTSAS+A YAAKAG++AYVL+P+GK+ALGK+AQA+++GAKVI I GNFDDALR+V
Sbjct: 122 ASTGNTSASMAMYAAKAGLKAYVLLPAGKVALGKVAQALMHGAKVIGIDGNFDDALRIVR 181
Query: 181 EASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKEL 240
E IY+LNSINPFR EGQKTIAYEI D++ VPD VVLPVGNAGNISAI+KGFKEL
Sbjct: 182 EVCSREPIYLLNSINPFRPEGQKTIAYEIADEI-GVPDRVVLPVGNAGNISAIYKGFKEL 240
Query: 241 YEAGVIDKLPRMIGIQAEGASPLAKAWKE-KRKFKPEKNPETLATAIRIGNPANWEKAWR 299
E G+ D +P+M GIQAEGA+P+ +A+KE K P +NPET+ATAIRIGNP + +KA R
Sbjct: 241 REVGLTDSMPKMTGIQAEGAAPIYRAFKEGKEDITPMENPETIATAIRIGNPVSAKKALR 300
Query: 300 AVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVL 359
A+ + G+ E+VSD EI++AQ+ LA+KEG+ VEPASAAS+AGL KL +D DE+ V
Sbjct: 301 AIYSTNGLAEVVSDSEIIEAQKFLAAKEGIGVEPASAASVAGLRKLAANGMLDPDETIVC 360
Query: 360 VTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVI 393
V TG+ LKDP+ V+R P +E +++A R +
Sbjct: 361 VVTGNLLKDPETVVRVCGEPVKVEASVEAVIRAM 394
>pir||G69131 threonine synthase (EC 4.2.99.2) - Methanobacterium
thermoautotrophicum >gi|2621303|gb|AAB84759.1|
(AE000812) threonine synthase [Methanobacterium
thermoautotrophicum]
Length = 406
Score = 440 bits (1120), Expect = e-122
Identities = 228/397 (57%), Positives = 296/397 (74%), Gaps = 7/397 (1%)
Query: 2 VLRCIRCGREYPEDEIRYRC-ECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPV--K 58
V+RCI CGREY +EI Y C ECG +LEV D++ V +F G +W+Y ++PV
Sbjct: 6 VIRCISCGREYDLEEIIYTCRECGSVLEVECDVE-VSRDVFRGRRQNMWRYREFMPVDPS 64
Query: 59 KIVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRV 118
+IVSL+EGGTP R + + LG+ ELY K EG+NPTGSFKDRGM+VG++KALELG+ V
Sbjct: 65 RIVSLDEGGTPFVRCDTIGSELGI-ELYVKVEGSNPTGSFKDRGMSVGITKALELGVDTV 123
Query: 119 ACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRV 178
CASTGNTSASLAAYAA+AG+ VL+PSGK+ALGKLAQA+ +GA+V+ ++GNFD+AL
Sbjct: 124 GCASTGNTSASLAAYAARAGLGCVVLLPSGKVALGKLAQAMFHGARVLSVRGNFDEALEA 183
Query: 179 VIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQL-QKVPDNVVLPVGNAGNISAIWKGF 237
V E + +Y+LNS+NPFRLEGQK+I +EI D L + PD ++LPVGNAGNISAIWKG
Sbjct: 184 VTELALMGELYLLNSVNPFRLEGQKSIGFEIVDDLGWESPDRIILPVGNAGNISAIWKGI 243
Query: 238 KELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKR-KFKPEKNPETLATAIRIGNPANWEK 296
E Y AG ID+ P M GIQAEGASP+ +A+++ R + +P ++PET+ATAIRIG P ++ K
Sbjct: 244 SEFYRAGFIDERPMMTGIQAEGASPVVEAFRKGRTEIEPVRDPETVATAIRIGAPVSYLK 303
Query: 297 AWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDES 356
A RA+ ES G E V+DEEIL AQ++LA +EG+ VEPASAAS+AGLIKL++E VDR E
Sbjct: 304 ALRAIYESDGYAESVTDEEILSAQKLLARREGIGVEPASAASIAGLIKLVDEGVVDRGER 363
Query: 357 FVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVI 393
V V TGH LKDPD ++ P +EP ++ R +I
Sbjct: 364 VVCVVTGHVLKDPDTAIKASTEPVEVEPDINQLRSII 400
>gb|AAK41164.1| Threonine synthase (thrC-2) [Sulfolobus solfataricus]
Length = 396
Score = 383 bits (972), Expect = e-105
Identities = 205/374 (54%), Positives = 267/374 (70%), Gaps = 14/374 (3%)
Query: 3 LRCIRCGREYPEDEIRYRC-ECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLP--VKK 59
++C+ CG E D+ + C CGGLLE++++ K D +W+Y+ + K
Sbjct: 1 MKCLNCGYETEIDQSQILCPRCGGLLEIILEPPK-DFSFSKLRGRGVWRYKELIAGRYKN 59
Query: 60 IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVA 119
IVS+NEG TPL R +N+ LY K EG NPTGSFKDRGMTV VS A+ L K V
Sbjct: 60 IVSINEGNTPLIRSSNIND-----NLYFKFEGLNPTGSFKDRGMTVAVSSAVSLNYKTVI 114
Query: 120 CASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVV 179
ASTGNT+AS AAYAA+AGI++++++P GK+ALGKLAQ+I+YG+ ++ + G+FD A+ V
Sbjct: 115 AASTGNTAASAAAYAARAGIKSFIVLPKGKVALGKLAQSILYGSVILEVDGSFDVAMDAV 174
Query: 180 IEASEELG-IYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFK 238
+ ++L +Y LNS NP+RLEGQKTIA+EI ++L VPDNV++PVGNAGNI AIWKGF
Sbjct: 175 MRLYKDLKVVYPLNSFNPWRLEGQKTIAFEIAEEL-GVPDNVIVPVGNAGNIYAIWKGFN 233
Query: 239 ELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPE--KNPETLATAIRIGNPANWEK 296
EL + GVI+ +PRMIGIQAEGASP+ A K K P+ +NP+T+ATAIRIG P NW+K
Sbjct: 234 ELVKTGVINTIPRMIGIQAEGASPIVTA-IIKGKDSPDFIENPDTVATAIRIGKPVNWQK 292
Query: 297 AWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDES 356
A +A+ ES G VSD EIL AQ+ LA KEG+ EPASAA+LAG IK +NE+ VD+DE
Sbjct: 293 AMKAIRESNGTAIAVSDSEILDAQKTLARKEGIGAEPASAAALAGYIKAINEKVVDKDEK 352
Query: 357 FVLVTTGHGLKDPD 370
VL+ TGH LKDPD
Sbjct: 353 TVLILTGHSLKDPD 366
>pir||G72364 threonine synthase (EC 4.2.99.2) TM0546 [similarity] - Thermotoga
maritima (strain MSB8)
>gi|4981060|gb|AAD35631.1|AE001729_11 (AE001729)
threonine synthase [Thermotoga maritima]
Length = 348
Score = 381 bits (968), Expect = e-105
Identities = 201/350 (57%), Positives = 253/350 (71%), Gaps = 11/350 (3%)
Query: 48 LWKYESWLPVKK---IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMT 104
L KY +LPV ++SLNEG TPL L N+ + LG+ +Y K EG+NPTGSFKDRGM
Sbjct: 6 LEKYRRFLPVTDKTPMLSLNEGNTPLIPLVNMSRELGIN-IYVKYEGSNPTGSFKDRGMV 64
Query: 105 VGVSKALELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAK 164
V V+KALE G K + CASTGNTSAS AAYAA+AGI+A VL+P GKIALGKLAQA+IYGA
Sbjct: 65 VAVAKALEEGSKAIMCASTGNTSASAAAYAARAGIKAIVLIPEGKIALGKLAQAMIYGAV 124
Query: 165 VIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPV 224
V+ ++GNFD L +V E + + I ++NSINP+RLEGQKT A+EI D+L PD +PV
Sbjct: 125 VLQVRGNFDKCLELVKEITSKYPITLVNSINPYRLEGQKTAAFEIVDELGDAPDYHFIPV 184
Query: 225 GNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLAT 284
GNAGNISA W G+KE Y+ G KLP+M+G QAEGA+P+ + P +NPET+AT
Sbjct: 185 GNAGNISAYWMGYKEYYQHGFSTKLPKMMGFQAEGAAPIVRG-------HPIENPETVAT 237
Query: 285 AIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIK 344
AIRIGNPANWEKA RA +ESGG ++VSDEEIL+AQR+LA KEG+F EPASAAS+AGL+K
Sbjct: 238 AIRIGNPANWEKAVRARDESGGDIDMVSDEEILRAQRLLAQKEGIFCEPASAASIAGLLK 297
Query: 345 LLNEEKVDRDESFVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVIE 394
+ E V TG+GLKDP+IV+ + P IE ++ V++
Sbjct: 298 KHRQGIFRGGEIVVCTLTGNGLKDPNIVISQLEPPRIIEGRVEEILEVLD 347
>pir||H70338 threonine synthase (EC 4.2.99.2) - Aquifex aeolicus
>gi|2983084|gb|AAC06690.1| (AE000689) threonine synthase
[Aquifex aeolicus]
Length = 352
Score = 370 bits (940), Expect = e-101
Identities = 189/348 (54%), Positives = 249/348 (71%), Gaps = 11/348 (3%)
Query: 50 KYESWLPVKK---IVSLNEGGTPLYRLNNLEKILGVK-ELYAKNEGANPTGSFKDRGMTV 105
+Y+ +LPV + IV+L EG TPL +NL + +G K ++Y K EG NPTGSFKDRGMT+
Sbjct: 10 QYKKYLPVDENTPIVTLYEGNTPLIEADNLARAIGFKGKIYLKYEGLNPTGSFKDRGMTL 69
Query: 106 GVSKALELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKV 165
+SKA+E G + V CASTGNTSAS AAYAA+AG+ AYVL+P G +A+GKL+QA+IYGAKV
Sbjct: 70 AISKAVEAGKRAVICASTGNTSASAAAYAARAGLRAYVLLPKGAVAIGKLSQAMIYGAKV 129
Query: 166 IPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVG 225
+ I+G FDDAL +V + E + ++NS+NP+R+EGQKT A+EI D L + PD +PVG
Sbjct: 130 LAIQGTFDDALNIVRKIGENFPVEIVNSVNPYRIEGQKTAAFEICDTLGEAPDYHFIPVG 189
Query: 226 NAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATA 285
NAGNI+A WKGFK YE G I KLPRM+G QAEGA+P+ K + P KNP+T+ATA
Sbjct: 190 NAGNITAYWKGFKIYYEEGKITKLPRMMGWQAEGAAPIVKGY-------PIKNPQTIATA 242
Query: 286 IRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKL 345
I+IGNP +W+ A +A +ESGG + VSD EIL A +++AS EG+F EPASAAS+AGLIKL
Sbjct: 243 IKIGNPYSWKSALKAAQESGGKIDAVSDSEILYAYKLIASTEGVFCEPASAASVAGLIKL 302
Query: 346 LNEEKVDRDESFVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVI 393
+ E E TG+GLKDPD ++ + P + P D +V+
Sbjct: 303 VREGFFKGGEVVTCTLTGNGLKDPDTAIKVCEEPITVPPDFDEVVKVL 350
>pir||B72455 threonine synthase (EC 4.2.99.2) APE2286 [similarity] - Aeropyrum
pernix (strain K1) >gi|5105987|dbj|BAA81298.1|
(AP000064) 393aa long hypothetical threonine synthase
[Aeropyrum pernix]
Length = 393
Score = 356 bits (903), Expect = 3e-97
Identities = 199/365 (54%), Positives = 247/365 (67%), Gaps = 11/365 (3%)
Query: 8 CGREYPEDEIRYRC-ECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLP-VKKIVSLNE 65
CG +YP + C +CGGLLE +D G + W+Y LP ++IV++ E
Sbjct: 3 CGSKYPSSPRLFTCPKCGGLLEPFY----IDGGSPRGRGV--WRYRDLLPRPRRIVTMGE 56
Query: 66 GGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACASTGN 125
G TPL +L NL + +GV E+Y K E NPTGSFKDRGMTVGVS A + V ASTGN
Sbjct: 57 GSTPLVKLENLSRAMGV-EVYGKLEFLNPTGSFKDRGMTVGVSIASSFSYRLVVAASTGN 115
Query: 126 TSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEE 185
T+AS+AAYA +AG+ +L+P G IA GKL+Q GA V+ ++G+FDDAL A+E+
Sbjct: 116 TAASMAAYARRAGLNPVILIPKGGIASGKLSQIAALGAWVLEVEGSFDDALDAARAAAEK 175
Query: 186 LGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
Y LNSINP+RLEGQKTIA+EI + + +V D+VV+PVGNAGNISAIWKGFKE G+
Sbjct: 176 GLAYSLNSINPYRLEGQKTIAFEILEDVDRV-DHVVVPVGNAGNISAIWKGFKEAGLLGL 234
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKR-KFKPEKNPETLATAIRIGNPANWEKAWRAVEES 304
PRM+G+QAEGASPL +AW EK + +NP T+A+AIRIGNP N KA AV ES
Sbjct: 235 PSMRPRMVGVQAEGASPLYRAWVEKMDSVERVRNPSTIASAIRIGNPVNAAKALAAVRES 294
Query: 305 GGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTGH 364
G+ VSD EILKA LA EG+ VEPASAASLAGLIKL N+ + S VL+ TGH
Sbjct: 295 DGLIISVSDAEILKAAATLAENEGMLVEPASAASLAGLIKLRNQGIIASGSSVVLILTGH 354
Query: 365 GLKDP 369
GLKDP
Sbjct: 355 GLKDP 359
>sp|P74193|THRC_SYNY3 THREONINE SYNTHASE >gi|7436917|pir||S75823 threonine synthase (EC
4.2.99.2) 2 - Synechocystis sp. (strain PCC 6803)
>gi|1653368|dbj|BAA18282.1| (D90913) threonine synthase
[Synechocystis sp.]
Length = 382
Score = 344 bits (872), Expect = 1e-93
Identities = 180/329 (54%), Positives = 233/329 (70%), Gaps = 13/329 (3%)
Query: 51 YESWLPVKK---IVSLNEGGTPLYRLNNLEKILGVK-ELYAKNEGANPTGSFKDRGMTVG 106
Y +LPV +V+L EG TPL + K +G ++ K +G NPTGSFKDRGMT+
Sbjct: 41 YRPYLPVSDQTPVVTLLEGNTPLIPAPAIAKRIGKDVRVFVKYDGLNPTGSFKDRGMTMA 100
Query: 107 VSKALELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVI 166
+SKA E G K V CASTGNTSA+ AAYA +AG+ A+V++P G +ALGKL QA+IYGA+VI
Sbjct: 101 ISKAKEAGAKAVICASTGNTSAAAAAYARRAGLRAFVIIPDGYVALGKLGQALIYGAEVI 160
Query: 167 PIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGN 226
I GNFDDAL V + SE + ++NS+NP+RLEGQKT A+EI D L + PD + +PVGN
Sbjct: 161 AIDGNFDDALTTVRQLSEHYPVTLVNSVNPYRLEGQKTAAFEIVDVLGQAPDWLCIPVGN 220
Query: 227 AGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAI 286
AGNI+A W GF + E G D+LPRM+G QA G++P + +P +PETLATAI
Sbjct: 221 AGNITAYWMGFCQYKELGKGDRLPRMMGFQAAGSAPFIQG-------QPISHPETLATAI 273
Query: 287 RIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLL 346
RIGNPANW+KAW A ES G F V+D EIL+A RILA++EG+F EPASAAS+AGL+K
Sbjct: 274 RIGNPANWDKAWAASRESNGEFHPVTDAEILEAYRILAAEEGVFCEPASAASVAGLLK-- 331
Query: 347 NEEKVDRDESFVLVTTGHGLKDPDIVLRN 375
+++V + V V TG+GLKDPD ++N
Sbjct: 332 QKDQVPAGATVVCVLTGNGLKDPDCAVQN 360
>sp|P09123|THRC_BRELA THREONINE SYNTHASE >gi|68321|pir||DWFKTG threonine synthase (EC
4.2.99.2) - Corynebacterium glutamicum
>gi|541381|pir||S41448 threonine synthase (EC 4.2.99.2)
- Bacillus sp >gi|452398|emb|CAA82669.1| (Z29562)
threonine synthase [Bacillus sp.]
Length = 352
Score = 341 bits (866), Expect = 7e-93
Identities = 185/334 (55%), Positives = 236/334 (70%), Gaps = 12/334 (3%)
Query: 48 LWKYESWLPVKKI---VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMT 104
L +Y S+LPV + VSL EG TPL L N+ K LGV +LY K EGANPTGSFKDRGM
Sbjct: 6 LKQYASYLPVNEKTPDVSLMEGNTPLIPLLNISKQLGV-QLYGKYEGANPTGSFKDRGMV 64
Query: 105 VGVSKALELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAK 164
+ V+KA E G + + CASTGNTSAS AAYAA+ G++ +++P GKIA GKLAQA+ YGA+
Sbjct: 65 MAVAKAKEEGSEAIICASTGNTSASAAAYAARLGMKCIIVIPEGKIAHGKLAQAVAYGAE 124
Query: 165 VIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPV 224
+I I+GNFDDAL+ V + E I ++NS+NP+R+EGQKT A+EI DQLQ PD + +PV
Sbjct: 125 IISIEGNFDDALKAVRNIAAEEPITLVNSVNPYRIEGQKTAAFEICDQLQNAPDVLAIPV 184
Query: 225 GNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLAT 284
GNAGNI+A WKGF E YE K PR+ G +AEGA+ + K + PET+AT
Sbjct: 185 GNAGNITAYWKGFCE-YEKEKGYKKPRIHGFEAEGAAAIVKG-------HVIEEPETIAT 236
Query: 285 AIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIK 344
AIRIGNPA+W A A E+S G ++VSDEEIL A R+LA EG+F EP S ASLAG+IK
Sbjct: 237 AIRIGNPASWSYAVEAAEQSHGEIDMVSDEEILHAYRLLAKTEGVFAEPGSNASLAGVIK 296
Query: 345 LLNEEKVDRDESFVLVTTGHGLKDPDIVLRNFKL 378
+ K+ + E+ V V TG+GLKDPDI + + +L
Sbjct: 297 HVESGKIKKGETVVAVLTGNGLKDPDIAISSNQL 330
>sp|Q10610|THRC_MYCTU PROBABLE THREONINE SYNTHASE >gi|7436919|pir||C70773 threonine
synthase (EC 4.2.99.2) thrC [similarity] - Mycobacterium
tuberculosis (strain H37RV) >gi|1322419|emb|CAA97760.1|
(Z73419) thrC [Mycobacterium tuberculosis]
Length = 360
Score = 336 bits (853), Expect = 2e-91
Identities = 181/336 (53%), Positives = 232/336 (68%), Gaps = 15/336 (4%)
Query: 52 ESWLPVKKIVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKAL 111
+ W PV +L EGGTPL NL K G ++ K EG NPTGSFKDRGMT+ V+ AL
Sbjct: 27 DDWTPV----TLLEGGTPLIAATNLSKQTGCT-IHLKVEGLNPTGSFKDRGMTMAVTDAL 81
Query: 112 ELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGN 171
G + V CASTGNTSAS AAYAA+AGI VL+P GKIA+GKLAQA+++GAK+I I GN
Sbjct: 82 AHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGN 141
Query: 172 FDDALRVVIE-ASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNI 230
FDD L + + A++ I ++NS+NP R+EGQKT A+EI D L PD LPVGNAGNI
Sbjct: 142 FDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNI 201
Query: 231 SAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGN 290
+A WKG+ E ++ G+IDKLPRM+G QA GA+PL +P +PET+ATAIRIG+
Sbjct: 202 TAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLG-------EPVSHPETIATAIRIGS 254
Query: 291 PANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEK 350
PA+W A A ++S G F SDEEIL A ++A EG+FVEPASAAS+AGL+K +++
Sbjct: 255 PASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGW 314
Query: 351 VDRDESFVLVTTGHGLKDPDIVLRNFK--LPEPIEP 384
V R + V TG+GLKDPD L++ P P++P
Sbjct: 315 VARGSTVVCTVTGNGLKDPDTALKDMPSVSPVPVDP 350
>gb|AAG20514.1| (AE005123) threonine synthase; ThrC1 [Halobacterium sp. NRC-1]
Length = 415
Score = 335 bits (850), Expect = 5e-91
Identities = 189/376 (50%), Positives = 247/376 (65%), Gaps = 13/376 (3%)
Query: 3 LRCIRCGREY-PEDEIRYRC-ECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKI 60
L C+ CG P ++ YRC EC GLLE D + F G + W+Y LPV
Sbjct: 20 LACVECGGTLAPFADVVYRCPECSGLLEARY-ADYPGFEAFSGRGV--WRYADALPVDAG 76
Query: 61 VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVAC 120
VS+ EG TPLY ++ GV ++ K+EG NPTGSFKDRGMTVGV A LG+ R+AC
Sbjct: 77 VSVQEGDTPLYEAPDVAAAAGVADVRVKHEGMNPTGSFKDRGMTVGVRVAERLGVDRLAC 136
Query: 121 ASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVI 180
ASTGNTSA+LAAY +A VL+P+GK+A GK+AQA ++GA++ + GNFDD L VV
Sbjct: 137 ASTGNTSAALAAYGGRADTPVLVLLPAGKVAAGKIAQAALHGARICEVDGNFDDCLDVVA 196
Query: 181 EASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKV----PDNVVLPVGNAGNISAIWKG 236
E + Y+LNS+NPFRLEGQKTIA+EI +Q + PD +VLPVGNAGN +A++K
Sbjct: 197 ELAARGEAYLLNSLNPFRLEGQKTIAFEILEQSRTATGEWPDRIVLPVGNAGNTAALYKA 256
Query: 237 FKELYEAGVI--DKLPRMIGIQAEGASPLAKAWKEKR-KFKPEKNPETLATAIRIGNPAN 293
F+EL AG + D++P + G+QA GA+P+ +A + R + + + ET ATAIRIGNP N
Sbjct: 257 FRELVAAGAMTDDEMPALTGVQAAGAAPMVEAVEAGRGRTERWTDVETRATAIRIGNPVN 316
Query: 294 WEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDR 353
KA V E+GG VSD+ I AQR+LA +G+ VEPASAAS+AGL+ L ++
Sbjct: 317 APKALPGVYETGGTAVAVSDDRITDAQRMLAG-DGIGVEPASAASVAGLLALRERGEISA 375
Query: 354 DESFVLVTTGHGLKDP 369
DE V +TTGH LKDP
Sbjct: 376 DERVVCLTTGHLLKDP 391
>dbj|BAB07140.1| (AP001518) threonine synthase [Bacillus halodurans]
Length = 354
Score = 330 bits (836), Expect = 2e-89
Identities = 176/340 (51%), Positives = 234/340 (68%), Gaps = 12/340 (3%)
Query: 48 LWKYESWLPVKK---IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMT 104
L +Y+ +LPV + +++L EG TPL L NL K GVK Y K EGANPTGSFKDRGM
Sbjct: 8 LQEYKEFLPVTEETPLLTLGEGNTPLIPLENLSKEWGVKA-YVKYEGANPTGSFKDRGMV 66
Query: 105 VGVSKALELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAK 164
+ V+KA E G + + CASTGNTSA+ AAY A+AG+ V++P GKIALGKLAQA++YGA+
Sbjct: 67 MAVAKAKEEGSRTIICASTGNTSAAAAAYGARAGLRCIVVIPEGKIALGKLAQAVMYGAE 126
Query: 165 VIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPV 224
V+ IKGNFD AL +V SE+ I ++NS+NP+R+EGQKT A+EI D L + PD + +PV
Sbjct: 127 VLEIKGNFDHALDIVRSISEKEPITLVNSVNPYRIEGQKTSAFEICDALGQAPDVLAIPV 186
Query: 225 GNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLAT 284
GNAGNI+A WKGFKE +E LP+M G +AEGA+ + + + + PET+AT
Sbjct: 187 GNAGNITAYWKGFKEYHEKKGTG-LPQMRGFEAEGAAAIVRN-------QVIEEPETIAT 238
Query: 285 AIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIK 344
AIRIGNPA+W A A ES G + V+DEEIL A ++LA KEG+F EPAS AS+AGL K
Sbjct: 239 AIRIGNPASWTYAVEAAAESNGKIDEVTDEEILAAYQLLAQKEGVFAEPASCASIAGLRK 298
Query: 345 LLNEEKVDRDESFVLVTTGHGLKDPDIVLRNFKLPEPIEP 384
+ ++ + + V V TG+GLKDP+ + + + P
Sbjct: 299 QIASGEIKKGSTVVCVLTGNGLKDPNTAMSTIDVNPAVLP 338
>sp|P04990|THRC_BACSU THREONINE SYNTHASE >gi|80429|pir||A25364 threonine synthase (EC
4.2.99.2) thrC - Bacillus subtilis
>gi|40211|emb|CAA28270.1| (X04603) threonine synthase
[Bacillus subtilis] >gi|2635722|emb|CAB15215.1| (Z99120)
threonine synthase [Bacillus subtilis]
Length = 352
Score = 327 bits (829), Expect = 2e-88
Identities = 168/331 (50%), Positives = 234/331 (69%), Gaps = 17/331 (5%)
Query: 48 LWK-----YESWLPVKK---IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFK 99
+WK Y+ +LPV ++L+EG TPL L L + LG+ EL+ K EG NPTGSFK
Sbjct: 1 MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGI-ELHVKTEGVNPTGSFK 59
Query: 100 DRGMTVGVSKALELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAI 159
DRGM + V+KA E G + CASTGNTSA+ AAYAA+A ++ V++P+GKIA GKLAQA+
Sbjct: 60 DRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCIVIIPNGKIAFGKLAQAV 119
Query: 160 IYGAKVIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDN 219
+YGA++I I GNFDDAL++V E+ I ++NS+NP+R+EGQKT A+E+ +QL + PD
Sbjct: 120 MYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIEGQKTAAFEVCEQLGEAPDV 179
Query: 220 VVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNP 279
+ +PVGNAGNI+A WKGFKE +E LP+M G +AEGA+ + + + +NP
Sbjct: 180 LAIPVGNAGNITAYWKGFKEYHEKNGTG-LPKMRGFEAEGAAAIVRN-------EVIENP 231
Query: 280 ETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASL 339
ET+ATAIRIGNPA+W+KA +A EES G + V+D+EIL A +++A EG+F EP S AS+
Sbjct: 232 ETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIARVEGVFAEPGSCASI 291
Query: 340 AGLIKLLNEEKVDRDESFVLVTTGHGLKDPD 370
AG++K + ++ + V V TG+GLKDP+
Sbjct: 292 AGVLKQVKSGEIPKGSKVVAVLTGNGLKDPN 322
>sp|P45837|THRC_MYCLE PROBABLE THREONINE SYNTHASE >gi|7436934|pir||T09991 threonine
synthase (EC 4.2.99.2) - Mycobacterium leprae
>gi|699329|gb|AAA63090.1| (U15186) threonine synthase
[Mycobacterium leprae]
Length = 360
Score = 321 bits (815), Expect = 7e-87
Identities = 172/332 (51%), Positives = 223/332 (66%), Gaps = 13/332 (3%)
Query: 52 ESWLPVKKIVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKAL 111
+ W PV +L EGGTPL L + G ++ K EG NPTGSFKDRGMT+ V+ AL
Sbjct: 27 DDWTPV----TLLEGGTPLIAAPRLSEQTGCT-IHLKVEGLNPTGSFKDRGMTMAVTDAL 81
Query: 112 ELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGN 171
G + V CASTGNTSAS AAYAA+AGI VL+P GKIA+GKLAQA+++GAK+I I GN
Sbjct: 82 ARGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGN 141
Query: 172 FDDALRVVIEASEELG-IYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNI 230
FDD L + + + + I ++NS+NP R+EGQKT +EI D L P LPVGNAGNI
Sbjct: 142 FDDCLELARKMAADFPMISLVNSVNPVRIEGQKTAVFEIVDALGTAPHVHALPVGNAGNI 201
Query: 231 SAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGN 290
+A WKG+ E + G+ID+LPRM+G QA GA+PL +P +PET+ATAIRIG+
Sbjct: 202 TAYWKGYTEYHADGLIDRLPRMLGTQAAGAAPLVLG-------EPVSHPETIATAIRIGS 254
Query: 291 PANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEK 350
PA+W A A ++S G F +DEEIL A ++A EG+FVEPASAAS+AGL+K ++
Sbjct: 255 PASWTSAVEAQQQSKGRFLAATDEEILAAYHLVARAEGVFVEPASAASIAGLLKAIDGGW 314
Query: 351 VDRDESFVLVTTGHGLKDPDIVLRNFKLPEPI 382
V R + V TG+GLKDPD L++ P+
Sbjct: 315 VARGSTVVCTITGNGLKDPDTALKDMPSVSPV 346
>pir||D70354 threonine synthase (EC 4.2.99.2) thrC1 [similarity] - Aquifex
aeolicus >gi|2983225|gb|AAC06822.1| (AE000698) threonine
synthase [Aquifex aeolicus]
Length = 409
Score = 282 bits (715), Expect = 4e-75
Identities = 157/400 (39%), Positives = 239/400 (59%), Gaps = 10/400 (2%)
Query: 3 LRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKI----FDGNNITLWKYESWLPVK 58
L+C CGREYP + I C G LEVV D D++ I + +LW+Y LPV+
Sbjct: 7 LKCRECGREYPAEPIHVCEFCFGPLEVVYDYDEIKKNISREKIEKGPKSLWRYVDLLPVE 66
Query: 59 K-IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGAN-PTGSFKDRGMTVGVSKALELGMK 116
V L G TPL + L ++LG+K LY K++ N PT SFKDR ++V +SKA E G
Sbjct: 67 NPTVGLTAGFTPLKKAEKLGEVLGLKNLYIKDDSVNHPTLSFKDRVVSVALSKAKEFGFD 126
Query: 117 RVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDAL 176
ACASTGN + S+AA++A+AG+ +V +P+ + K+ ++++ V+ ++GN+DD
Sbjct: 127 TAACASTGNLANSVAAHSAQAGMNCFVFIPAN-LETQKIIGSLVFNPTVVAVEGNYDDVN 185
Query: 177 RVVIEASEELGIYMLN-SINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVGNAGNISAIW 234
R+ E + +LG +N +I P+ EG KT+A+E+ +QL + PD VV P + + IW
Sbjct: 186 RLCSEIANDLGWAFVNINIRPYYAEGSKTLAFEVAEQLGWRAPDVVVAPAASGSLYTKIW 245
Query: 235 KGFKELYEAGVIDKLP-RMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPAN 293
KGF EL + G+ID++ RM G QAEG SP+A+AW+E R F P T+A +I IGNPA+
Sbjct: 246 KGFNELKKVGLIDEVKTRMYGAQAEGCSPIAQAWREGRDFIKPVKPNTIAKSIAIGNPAD 305
Query: 294 WEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDR 353
A + ES G +E +DEEI++ ++LA EG+F E A ++A L K + + +
Sbjct: 306 GIYALQVARESNGAWETATDEEIIEGIKLLAQTEGIFTETAGGTTIAVLKKYVEKGMISP 365
Query: 354 DESFVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVI 393
+E+ V+ TG+G K +++ P I+PTL F+ +
Sbjct: 366 EETVVVYITGNGYKTMEVLEGKLSTPVKIKPTLKDFKEKV 405
>gi|11498161 threonine synthase (thrC-1) [Archaeoglobus fulgidus]
>gi|7436927|pir||G69318 threonine synthase (EC 4.2.99.2)
thrC-1 AF0551 [similarity] - Archaeoglobus fulgidus
>gi|2650068|gb|AAB90683.1| (AE001066) threonine synthase
(thrC-1) [Archaeoglobus fulgidus]
Length = 404
Score = 263 bits (666), Expect = 2e-69
Identities = 151/401 (37%), Positives = 234/401 (57%), Gaps = 10/401 (2%)
Query: 1 MVLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKI----FDGNNITLWKYESWLP 56
+ L+C CG EYP + + + C G LE V D + + + ++W+Y +LP
Sbjct: 4 VALKCRICGTEYPPEPLYHCSLCFGPLEAVYDYEGIKESVSKEEISKRVQSVWRYREFLP 63
Query: 57 VKKI-VSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGM 115
V L G T NL + LG+K LY ++ NPT SFKDR ++V V+KALE GM
Sbjct: 64 TNHDPVDLGAGFTRFIHAKNLGECLGLKNLYLLDDSTNPTYSFKDRVVSVAVTKALEFGM 123
Query: 116 KRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDA 175
V CASTGN + SLAA+AAKAG++A++ VP+G I K+ QA+++GA V+ + G +DDA
Sbjct: 124 DVVGCASTGNLAGSLAAHAAKAGLKAFIFVPAG-IEKNKIVQALVHGATVVEVNGTYDDA 182
Query: 176 LRVVIEASEELGIYMLNSIN--PFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVGNAGNISA 232
R+ E +E+ + +IN P+ +EG KT+A+E ++L + P VV+PV + + +
Sbjct: 183 NRLAAEIAEKNRNWGFVNINLRPYYVEGSKTLAFEAAERLGWEAPSQVVVPVASGALLYS 242
Query: 233 IWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPA 292
I++GFKEL G+ID P+A+A KE+R+ +P + T+ ++ IGNPA
Sbjct: 243 IYRGFKELETVGLIDSAEVAFNAAQPEGFPVARAVKERRQVEPIERFSTIVHSLAIGNPA 302
Query: 293 NWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVD 352
+ A VE SGG E SD E+++A ++LA EG+F E A ++A LI+L+ + ++D
Sbjct: 303 DGIFAKEVVERSGGYAEDPSDAEVIEAVKLLARTEGIFTELAGGVTVAALIRLVEDGRID 362
Query: 353 RDESFVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVI 393
RDE V TG+GLK + V + I+ ++ F +V+
Sbjct: 363 RDEKVVAYLTGNGLKTAEAVAETLSTVK-IDARVEEFEKVL 402
>pir||S77200 threonine synthase (EC 4.2.99.2) 1 - Synechocystis sp. (strain PCC
6803) >gi|1652839|dbj|BAA17758.1| (D90908) threonine
synthase [Synechocystis sp.]
Length = 433
Score = 252 bits (636), Expect = 7e-66
Identities = 147/394 (37%), Positives = 227/394 (57%), Gaps = 11/394 (2%)
Query: 11 EYPEDEIRYRCECGGLLEVVVDLD----KVDTKIFDGNNITLWKYESWLPV--KKIVSLN 64
EYP + E LEV D D V + + ++W+Y ++LPV K ++ +
Sbjct: 26 EYPLKALHICEETFAPLEVAYDYDLIRRHVTRETIEAGPNSIWRYRAFLPVTGKDVIDVG 85
Query: 65 EGGTPLYRLNNLEKILGVKELYAKNEGAN-PTGSFKDRGMTVGVSKALELGMKRVACAST 123
G TPL + + L + LG+K LY KN+ N PT SFKDR ++V +++A ELG V+CAST
Sbjct: 86 TGMTPLVKSHRLARRLGLKNLYIKNDAVNMPTLSFKDRVVSVALTRARELGFTTVSCAST 145
Query: 124 GNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEAS 183
GN + S AA AA AG++ V +P+ + GK+ +IY ++ +KGN+D R+ E
Sbjct: 146 GNLANSTAAIAAHAGLDCCVFIPAD-LEAGKVLGTLIYNPTLMAVKGNYDQVNRLCCEVG 204
Query: 184 EELGIYMLN-SINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVGNAGNISAIWKGFKELY 241
G +N ++ P+ EG KT+ +E+ +QL K+PD++V P+ + + I KGF+E
Sbjct: 205 NSYGWGFVNINLRPYYSEGSKTLGFEVAEQLGWKLPDHIVAPLASGSLFTKIHKGFQEFI 264
Query: 242 EAGVIDKLP-RMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRA 300
+ G++D P R G QAEG SP+A A++E R F P T+A +I IGNPA+ A
Sbjct: 265 KVGLVDDKPVRFSGAQAEGCSPIATAFQEGRDFVKPVKPNTIAKSIAIGNPADGVYALDI 324
Query: 301 VEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLV 360
++ G E V+D EI++ ++LA EG+F E A ++A L KL+ K+D +E+ V+
Sbjct: 325 ARKTNGNIESVNDAEIIEGIKLLAETEGIFTETAGGTTVAVLKKLVEAGKIDPEETTVVY 384
Query: 361 TTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVIE 394
TG+GLK + V + P I+ LD+F R +E
Sbjct: 385 ITGNGLKTQEAVQSHVGEPLTIDANLDSFERALE 418
>pir||H71013 probable threonine synthase (EC 4.2.99.2) PH1406 [similarity] -
Pyrococcus horikoshii >gi|3257829|dbj|BAA30512.1|
(AP000006) 440aa long hypothetical threonine synthase
[Pyrococcus horikoshii]
Length = 440
Score = 245 bits (620), Expect = 5e-64
Identities = 144/367 (39%), Positives = 222/367 (60%), Gaps = 13/367 (3%)
Query: 3 LRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLP-VKKIV 61
++C RCGREY I C CG LE+ D VD + + N +W+Y+ LP VKKI+
Sbjct: 1 MKCPRCGREYISS-IPPFCICGEELEITYDYSSVDVRKWKRRNPGVWRYKELLPEVKKII 59
Query: 62 SLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACA 121
+L EGGTPL + EKI ++Y K+E NPTGSF+DR TV +S L A
Sbjct: 60 TLQEGGTPLIKARISEKIN--VDVYIKDETRNPTGSFRDRLATVAISYGLPYASNGFIVA 117
Query: 122 STGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIE 181
S GN +AS+AAY+A+A E +V+VP K+ GKL Q I +GA++I + D+A+ E
Sbjct: 118 SDGNAAASVAAYSARAEKECFVVVPR-KVDKGKLIQMIAFGARIIRYGDSVDEAIEYARE 176
Query: 182 ASEELGIYMLN-SINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKEL 240
S+ G+Y + N LEGQKTIA+E+++++ P +V++P G+ I +I+KGFKEL
Sbjct: 177 LSKLNGLYNVTPEDNIIGLEGQKTIAFELWEEIN--PTHVIVPTGSGSYIYSIYKGFKEL 234
Query: 241 YEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRA 300
+ GV++K+PR+I +Q E +P+A +K + ET A + + NP + RA
Sbjct: 235 IKIGVLEKMPRLIAVQTERCNPIAAEILGLKK----ECKETKALGLYVKNPVMKSRVIRA 290
Query: 301 VEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLV 360
++ESGG +V++ +I+ +++LA+ EG+F E +SA + L+ L+ + +++ + VLV
Sbjct: 291 IKESGGTAVVVNENDIITGEKLLAN-EGIFAELSSAVVMPALLSLVEKGIIEKGDKVVLV 349
Query: 361 TTGHGLK 367
TG GLK
Sbjct: 350 VTGSGLK 356
>pir||E75118 probable threonine synthase (EC 4.2.99.2) thrc-2 PAB1869
[similarity] - Pyrococcus abyssi (strain Orsay)
>gi|5458173|emb|CAB49662.1| (AJ248285) threonine
synthase (thrC-2) [Pyrococcus abyssi]
Length = 439
Score = 245 bits (619), Expect = 6e-64
Identities = 147/367 (40%), Positives = 223/367 (60%), Gaps = 13/367 (3%)
Query: 3 LRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLP-VKKIV 61
++C +CGREY + EI C CG LE+ D VDT+ + +W+Y+ LP VKKIV
Sbjct: 1 MKCPKCGREY-KAEIPPFCICGEELEITYDYSSVDTRKWKNRRPGVWRYKELLPKVKKIV 59
Query: 62 SLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACA 121
SL EGGTPL + E++ +++ K+E NPTGSF+DR TV +S L A
Sbjct: 60 SLQEGGTPLIKARISEQLN--VDVFIKDETRNPTGSFRDRLATVAISYGLPYAKNGFIVA 117
Query: 122 STGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIE 181
S GN +AS+AAY+A+A E +V++P K+ GKL Q I +GA++I + DDA+ E
Sbjct: 118 SDGNAAASVAAYSARAEKECFVVIPR-KVDKGKLIQMIAFGARIIRYGESVDDAIEYAKE 176
Query: 182 ASEELGIYMLN-SINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKEL 240
++ G+Y + N LEGQKTIA+E+++++ P +V++P G+ + +I+KGFKEL
Sbjct: 177 LAKLNGLYNVTPEENIVGLEGQKTIAFELWEEIN--PTHVIVPTGSGSYLYSIYKGFKEL 234
Query: 241 YEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRA 300
E G ++++P++I +Q + +P+A E K E ET A + + P K RA
Sbjct: 235 IEIGALEEMPKLIAVQTDRCNPIA---SEILGIKGECK-ETKALGLYVREPLMKPKVIRA 290
Query: 301 VEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLV 360
+ ES G +VS+EEI K +R+LA+ EG+F E +SA + LIKL+N+ +++ + VLV
Sbjct: 291 IRESSGTAVLVSEEEIEKGERLLAN-EGIFAELSSAVVMPALIKLVNDGFIEKGDRVVLV 349
Query: 361 TTGHGLK 367
TG GLK
Sbjct: 350 VTGSGLK 356
>pir||S71362 threonine synthase (EC 4.2.99.2) precursor - Arabidopsis thaliana
(fragment) >gi|1448917|gb|AAB04607.1| (L41666) threonine
synthase [Arabidopsis thaliana]
Length = 525
Score = 242 bits (612), Expect = 4e-63
Identities = 158/385 (41%), Positives = 224/385 (58%), Gaps = 32/385 (8%)
Query: 12 YPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGN----------NITLWKYESWLPVKK-- 59
Y DEI YR GGLL+V D++ + K FDG + W Y S + KK
Sbjct: 95 YSLDEIVYRSRSGGLLDVEHDMEAL--KRFDGAYWRDLFDSRVGKSTWPYGSGVWSKKEW 152
Query: 60 ---------IVSLNEGGTPLYRLNNLEK-ILGVKELYAKNEGANPTGSFKDRGMTVGVSK 109
IVS EG + L+ K LG+ +L+ K+ G + TGSFKD GMTV VS+
Sbjct: 153 VLPEIDDDDIVSAFEGNSNLFWAERFGKQFLGMNDLWVKHCGISHTGSFKDLGMTVLVSQ 212
Query: 110 ALELG-MKR----VACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAK 164
L MKR V CASTG+TSA+L+AY A AGI + V +P+ KI++ +L Q I GA
Sbjct: 213 VNRLRKMKRPVVGVGCASTGDTSAALSAYCASAGIPSIVFLPANKISMAQLVQPIANGAF 272
Query: 165 VIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLP 223
V+ I +FD ++++ E + EL IY+ NS+N RLEGQKT A EI Q +VPD V++P
Sbjct: 273 VLSIDTDFDGCMKLIREITAELPIYLANSLNSLRLEGQKTAAIEILQQFDWQVPDWVIVP 332
Query: 224 VGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRK-FKPEKNPETL 282
GN GNI A +KGFK E G++D++PRM+ QA A+PL +K K FKP T
Sbjct: 333 GGNLGNIYAFYKGFKMCQELGLVDRIPRMVCAQAANANPLYLHYKSGWKDFKPMTASTTF 392
Query: 283 ATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGL 342
A+AI+IG+P + ++A A+++ G+ E ++EE++ A A G+F+ P + +L L
Sbjct: 393 ASAIQIGDPVSIDRAVYALKKCNGIVEEATEEELMDAM-AQADSTGMFICPHTGVALTAL 451
Query: 343 IKLLNEEKVDRDESFVLVTTGHGLK 367
KL N+ + + V+V+T HGLK
Sbjct: 452 FKLRNQGVIAPTDRTVVVSTAHGLK 476
>pir||T08545 threonine synthase (EC 4.2.99.2) precursor - Arabidopsis thaliana
>gi|4850369|dbj|BAA77707.1| (AB027151) threonine
synthase [Arabidopsis thaliana]
>gi|4914408|emb|CAB43659.1| (AL050352) threonine
synthase [Arabidopsis thaliana]
>gi|7269883|emb|CAB79742.1| (AL161575) threonine
synthase [Arabidopsis thaliana]
Length = 526
Score = 242 bits (612), Expect = 4e-63
Identities = 158/385 (41%), Positives = 224/385 (58%), Gaps = 32/385 (8%)
Query: 12 YPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGN----------NITLWKYESWLPVKK-- 59
Y DEI YR GGLL+V D++ + K FDG + W Y S + KK
Sbjct: 96 YSLDEIVYRSRSGGLLDVEHDMEAL--KRFDGAYWRDLFDSRVGKSTWPYGSGVWSKKEW 153
Query: 60 ---------IVSLNEGGTPLYRLNNLEK-ILGVKELYAKNEGANPTGSFKDRGMTVGVSK 109
IVS EG + L+ K LG+ +L+ K+ G + TGSFKD GMTV VS+
Sbjct: 154 VLPEIDDDDIVSAFEGNSNLFWAERFGKQFLGMNDLWVKHCGISHTGSFKDLGMTVLVSQ 213
Query: 110 ALELG-MKR----VACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAK 164
L MKR V CASTG+TSA+L+AY A AGI + V +P+ KI++ +L Q I GA
Sbjct: 214 VNRLRKMKRPVVGVGCASTGDTSAALSAYCASAGIPSIVFLPANKISMAQLVQPIANGAF 273
Query: 165 VIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLP 223
V+ I +FD ++++ E + EL IY+ NS+N RLEGQKT A EI Q +VPD V++P
Sbjct: 274 VLSIDTDFDGCMKLIREITAELPIYLANSLNSLRLEGQKTAAIEILQQFDWQVPDWVIVP 333
Query: 224 VGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRK-FKPEKNPETL 282
GN GNI A +KGFK E G++D++PRM+ QA A+PL +K K FKP T
Sbjct: 334 GGNLGNIYAFYKGFKMCQELGLVDRIPRMVCAQAANANPLYLHYKSGWKDFKPMTASTTF 393
Query: 283 ATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGL 342
A+AI+IG+P + ++A A+++ G+ E ++EE++ A A G+F+ P + +L L
Sbjct: 394 ASAIQIGDPVSIDRAVYALKKCNGIVEEATEEELMDAM-AQADSTGMFICPHTGVALTAL 452
Query: 343 IKLLNEEKVDRDESFVLVTTGHGLK 367
KL N+ + + V+V+T HGLK
Sbjct: 453 FKLRNQGVIAPTDRTVVVSTAHGLK 477
>gb|AAF74984.1|AF082894_1 (AF082894) threonine synthase [Solanum tuberosum]
Length = 519
Score = 240 bits (607), Expect = 2e-62
Identities = 155/385 (40%), Positives = 221/385 (57%), Gaps = 32/385 (8%)
Query: 12 YPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGN----------NITLWKYESWLPVKK-- 59
Y DEI YR GGLL+V D+D + K FDG T W Y S + KK
Sbjct: 89 YSLDEIVYRSRSGGLLDVQHDMDAL--KKFDGQYWRSLFDSRVGKTTWPYGSGVWSKKEW 146
Query: 60 ---------IVSLNEGGTPLYRLNNLEK-ILGVKELYAKNEGANPTGSFKDRGMTVGVSK 109
IVS EG + L+ K LG+ +L+ K+ G + TGSFKD GMTV VS+
Sbjct: 147 VLPEIDSDDIVSAFEGNSNLFWAERFGKQFLGMTDLWVKHCGISHTGSFKDLGMTVLVSQ 206
Query: 110 ALELGMKR-----VACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAK 164
L V CASTG+TSA+L+AY A AGI + V +P+ KI++ +L Q I GA
Sbjct: 207 VNRLRKMHKPVVGVGCASTGDTSAALSAYCASAGIPSIVFLPANKISMAQLVQPIANGAF 266
Query: 165 VIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLP 223
V+ I +FD ++++ E + EL IY+ NS+N RLEGQKT A EI Q +VP+ V++P
Sbjct: 267 VLSIDTDFDGCMQLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFDWEVPEWVIVP 326
Query: 224 VGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRK-FKPEKNPETL 282
GN GNI A +KGF+ E G++D++PR++ QA A+PL +K K FKP K T
Sbjct: 327 GGNLGNIYAFYKGFQMCKELGLVDRIPRLVCAQAANANPLYLHYKSGWKDFKPVKANTTF 386
Query: 283 ATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGL 342
A+AI+IG+P + ++A A+++ G+ E ++EE++ A A G+F+ P + +L L
Sbjct: 387 ASAIQIGDPVSIDRAVFALQQCNGIVEEATEEELMDAM-AQADSTGMFICPHTGVALTAL 445
Query: 343 IKLLNEEKVDRDESFVLVTTGHGLK 367
KL N + + V+V+T HGLK
Sbjct: 446 FKLRNSGVIAPTDRTVVVSTAHGLK 470
>gb|AAG19064.1| (AE005005) threonine synthase; ThrC2 [Halobacterium sp. NRC-1]
Length = 398
Score = 233 bits (589), Expect = 2e-60
Identities = 142/381 (37%), Positives = 209/381 (54%), Gaps = 12/381 (3%)
Query: 3 LRCIRCGREYPEDEIRYRC-ECGGLLEVVVDLDK--VDTKIFDGNNI-TLWKYESWLPVK 58
L C+ CG + +RC ECGG+L+ DL+ VD + F +LW+Y LP
Sbjct: 10 LECVDCGESFAAAAATHRCPECGGILDPAYDLENLDVDAETFGARRFDSLWRYAELLPFT 69
Query: 59 K--IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMK 116
+ VS++EG T L L LGV ELY K+EG NPTG+F+DRG TV ++ A + G
Sbjct: 70 RGSAVSMDEGATALVPCPGLADELGVGELYIKDEGRNPTGTFRDRGQTVAMTAAAQHGAS 129
Query: 117 RVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDAL 176
VA ASTGN S AYA +AG++A+V +PS + A ++G + ++G DA
Sbjct: 130 EVALASTGNAGQSAGAYAGRAGLDAHVFLPS-RSGFTTKAMVNVHGGDMNVVQGRIGDAN 188
Query: 177 RVVIEASEELG--IYMLNSI-NPFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVGNAGNISA 232
+A +E G Y L + P+R EG+KT+ YE +QL + PD+VV P G+ G +
Sbjct: 189 AAFEDAMDEHGEAWYSLQAFATPYRHEGKKTLLYETVEQLDWETPDHVVYPTGDGGGLVG 248
Query: 233 IWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKR-KFKPEKNPETLATAIRIGNP 291
+WK EL E G+ +P M QAEG +P+ +A++E R +P P+T+ I I +P
Sbjct: 249 MWKAATELRELGITADVPAMYAAQAEGCAPIVRAFQEGRDAHEPWDTPDTICGGIEIPDP 308
Query: 292 ANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKV 351
A A+ ES G SDEEIL+A +AS+ G + AA+ AG +L + +
Sbjct: 309 AGSRLVLEALRESNGGAVAASDEEILEAGTAVASRAGPEMGATCAAAAAGAWELADRDAF 368
Query: 352 DRDESFVLVTTGHGLKDPDIV 372
D++ V+V+TG K D++
Sbjct: 369 GEDDTVVVVSTGTANKAADVL 389
>gb|AAD55628.1|AC008017_1 (AC008017) Putative threonine synthase [Arabidopsis thaliana]
Length = 516
Score = 231 bits (582), Expect = 1e-59
Identities = 152/384 (39%), Positives = 220/384 (56%), Gaps = 29/384 (7%)
Query: 12 YPEDEIRYRCECGGLLEVVVD---LDKVDTK----IFDGN-NITLWKYESWLPVKK---- 59
Y DEI YR + G LL+V D L + D + +FD T W Y S + KK
Sbjct: 87 YSLDEIVYRSQSGALLDVQHDFAALKRYDGEFWRNLFDSRVGKTNWPYGSGVWSKKEWVL 146
Query: 60 -------IVSLNEGGTPLYRLNNLEK-ILGVKELYAKNEGANPTGSFKDRGMTVGVSKAL 111
IVS EG + L+ K L + +L+ K+ G + TGSFKD GM+V VS+
Sbjct: 147 PEIDDDDIVSAFEGNSNLFWAERFGKQYLQMNDLWVKHCGISHTGSFKDLGMSVLVSQVN 206
Query: 112 ELGMKR-----VACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVI 166
L V CASTG+TSA+L+AY A AGI + V +P+ KI++ +L Q I GA V+
Sbjct: 207 RLRKMNKPVIGVGCASTGDTSAALSAYCASAGIPSIVFLPADKISMAQLVQPIANGAFVL 266
Query: 167 PIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVG 225
I +FD + ++ E + EL IY+ NS+N RLEGQKT A EI Q +VPD V++P G
Sbjct: 267 SIDTDFDGCMHLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFNWQVPDWVIVPGG 326
Query: 226 NAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKE--KRKFKPEKNPETLA 283
N GNI A +KGF E G++D++PR++ QA A+PL +K K F P K T A
Sbjct: 327 NLGNIYAFYKGFHMCKELGLVDRIPRLVCAQAANANPLYLHYKSGFKEDFNPLKANTTFA 386
Query: 284 TAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLI 343
+AI+IG+P + ++A A+++S G+ E ++EE++ A LA G+F+ P + +L L+
Sbjct: 387 SAIQIGDPVSIDRAVYALKKSNGIVEEATEEELMDA-TALADSTGMFICPHTGVALTALM 445
Query: 344 KLLNEEKVDRDESFVLVTTGHGLK 367
KL + ++ V+V+T HGLK
Sbjct: 446 KLRKSGVIGANDRTVVVSTAHGLK 469
>emb|CAB93053.1| (AL357432) putative threonine synthase [Streptomyces coelicolor
A3(2)]
Length = 428
Score = 229 bits (579), Expect = 3e-59
Identities = 142/404 (35%), Positives = 215/404 (53%), Gaps = 19/404 (4%)
Query: 3 LRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDT----KIFDGNNITLWKYESWLPVK 58
L C CG P + EC G LE+ D D K + +W+Y LPV
Sbjct: 23 LSCRECGHRVPLGPVFACEECFGPLEIAYDFSDYDAEELRKRIEAGPANIWRYAPLLPVP 82
Query: 59 KIVS----LNEGGTPLYRLNNLEKILGVKE-LYAKNEGANPTGSFKDRGMTVGVSKALEL 113
V+ +N G T L + +NL + LGV LY K++ NPT SFKDR + + A
Sbjct: 83 ADVATKPNINPGWTKLVQADNLARELGVTGGLYVKDDSGNPTHSFKDRVVAQAIEAARAF 142
Query: 114 GMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFD 173
G ++C+STGN + ++ A AA+AG + V +P + GK+ A +YG +++ I+GN+D
Sbjct: 143 GFTTLSCSSTGNLAGAVGAAAARAGFRSCVFIPHD-LEQGKVVMAAVYGGELVGIEGNYD 201
Query: 174 DALRVVIE-----ASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVGNA 227
D R E A E G +N + P+ EG KT+AYEI +QL ++PD +V+P+ +
Sbjct: 202 DVNRFCSELIGDPAGEGWGFVNVN-LRPYYAEGSKTLAYEICEQLGWRLPDQIVVPIASG 260
Query: 228 GNISAIWKGFKELYEAGVIDKLP-RMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAI 286
++ I KG KEL E G+++ P ++ G QAEG SP++ A+K + P T+A ++
Sbjct: 261 SQLTKIDKGLKELIELGLVEDRPYKIFGAQAEGCSPVSTAYKAGHDVVRPQKPNTIAKSL 320
Query: 287 RIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLL 346
IGNPA+ +GG E V+DE+++ A ++LA EG+F E A ++ KL+
Sbjct: 321 AIGNPADGPYVLDIARRTGGAVEDVTDEQVVDAIKLLARTEGIFAETAGGVTVGVTRKLI 380
Query: 347 NEEKVDRDESFVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFR 390
+D + V++ TG GLK D V L I P LD+FR
Sbjct: 381 ENGVLDPSLTTVVLNTGDGLKTLDAV-AGTGLTATIRPNLDSFR 423
>pir||C71042 probable threonine synthase (EC 4.2.99.2) PH1627 [similarity] -
Pyrococcus horikoshii >gi|3258056|dbj|BAA30739.1|
(AP000006) 346aa long hypothetical threonine synthase
[Pyrococcus horikoshii]
Length = 346
Score = 180 bits (451), Expect = 3e-44
Identities = 134/367 (36%), Positives = 194/367 (52%), Gaps = 35/367 (9%)
Query: 1 MVLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPV--K 58
++L C +CGR++ E++ RC CGG L V D + F + + +Y +LPV K
Sbjct: 3 LMLICSKCGRKF-EEKFILRCTCGGTLLVKRKYDSFAPRKF----LDIRRYIDYLPVDEK 57
Query: 59 KIVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRV 118
+ SL G TP+ ++++ E+Y K + PTGSFKDRG V V+K E G+ V
Sbjct: 58 FLPSLTPGITPISKISD--------EVYLKLDYLQPTGSFKDRGTYVTVAKIKEEGIDEV 109
Query: 119 ACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRV 178
S+GN SLA Y GI+ +V + S K+A+ A++ ++G D +RV
Sbjct: 110 VIDSSGNAGLSLATYGMAEGIKVHVFL-SYNAKPEKIARLNSVNARLHFVEG---DRMRV 165
Query: 179 VIEA---SEELGI-YMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIW 234
EA SE GI Y + +NP+ LEG KTIA+EIY+Q+ +P + +PVG+ IW
Sbjct: 166 HEEAVKFSERTGIPYASHWLNPYFLEGTKTIAFEIYEQIG-IPRYIFVPVGSGTAFLGIW 224
Query: 235 KGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANW 294
KGFKEL E G I+K+P ++ +QAEG L K K K LA I I NP
Sbjct: 225 KGFKELLEMGEINKMPSLVAVQAEGYESLCKRSKSVNK---------LADGIAIPNPPRI 275
Query: 295 EKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRD 354
E+ A+ E+ G V +EE L L + G F+E SA +LAG K E+ + +
Sbjct: 276 EEMKVALRETSGFCISVGEEETLAGYHWL-RRNGFFIEETSATALAGYWK-AREKGLVKG 333
Query: 355 ESFVLVT 361
S +L+T
Sbjct: 334 SSLLLLT 340
>gb|AAB40316.1| (U46200) threonine synthase [Cloning vector pDG1663]
>gi|1185595|gb|AAB40324.1| (U46201) threonine synthase
[Cloning vector pDG1664] >gi|1185603|gb|AAB40331.1|
(U46202) threonine synthase [Cloning vector pDG1729]
>gi|1185612|gb|AAB40339.1| (U46203) threonine synthase
[Cloning vector pDG1731]
Length = 167
Score = 176 bits (443), Expect = 3e-43
Identities = 90/168 (53%), Positives = 122/168 (72%), Gaps = 9/168 (5%)
Query: 48 LWK-----YESWLPVKK---IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFK 99
+WK Y+ +LPV ++L+EG TPL L L + LG+ EL+ K EG NPTGSFK
Sbjct: 1 MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGI-ELHVKTEGVNPTGSFK 59
Query: 100 DRGMTVGVSKALELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAI 159
DRGM + V+KA E G + CASTGNTSA+ AAYAA+A ++ V++P+GKIA GKLAQA+
Sbjct: 60 DRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCIVIIPNGKIAFGKLAQAV 119
Query: 160 IYGAKVIPIKGNFDDALRVVIEASEELGIYMLNSINPFRLEGQKTIAY 207
+YGA++I I GNFDDAL++V E+ I ++NS+NP+R+EGQKT A+
Sbjct: 120 MYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIEGQKTAAF 167
>pir||E75172 probable threonine synthase (EC 4.2.99.2) thrc-2 PAB0369
[similarity] - Pyrococcus abyssi (strain Orsay)
>gi|5457970|emb|CAB49460.1| (AJ248284) related threonine
synthase (thrC-2) [Pyrococcus abyssi]
Length = 343
Score = 173 bits (433), Expect = 4e-42
Identities = 125/354 (35%), Positives = 179/354 (50%), Gaps = 28/354 (7%)
Query: 2 VLRCIRCGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKIV 61
+L C +CGR + E + RC CGG L V + T N + + +Y +LPV +
Sbjct: 1 MLVCTKCGRTFDE-KFLLRCTCGGTLLV----KRHYTSFSPRNYLDMRRYIDYLPVDSVF 55
Query: 62 --SLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVA 119
L TP+ + + ++LY K + PTGSFKDRG V ++K E G+ V
Sbjct: 56 LPKLTPAITPIVKDS--------EDLYLKLDYLQPTGSFKDRGTYVTIAKLKEEGINEVV 107
Query: 120 CASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVV 179
S+GN SLAAY GI+ +V + S K+++ AK+ + G+
Sbjct: 108 IDSSGNAGISLAAYGLSEGIKVHVFL-SYDANKEKISRLSALNAKLHFVDGDRMKVHEEA 166
Query: 180 IEASEELGI-YMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFK 238
I S + + Y+ + +NP+ LEG KTIA+EIY+Q+ K+PD V +PVG+ IWKGFK
Sbjct: 167 IRFSRDGNLTYVSHWMNPYFLEGTKTIAFEIYEQI-KLPDYVFIPVGSGTAFLGIWKGFK 225
Query: 239 ELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAW 298
EL E G I+ +P ++ +QAEG L K K K TLA I I P E+
Sbjct: 226 ELIEMGEIESMPSLVAVQAEGFESLCKRSKRK---------NTLADGIAIPEPPRIEEMK 276
Query: 299 RAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVD 352
+A++ES G V EE L + L K G+ VE SA +LA K E +D
Sbjct: 277 QAIKESSGFCISVGKEETLASLHWL-RKRGILVEGTSAVTLAAYWKAKELELID 329
>gb|AAK40813.1| Threonine synthase (thrC-1) [Sulfolobus solfataricus]
Length = 345
Score = 171 bits (429), Expect = 1e-41
Identities = 128/368 (34%), Positives = 196/368 (52%), Gaps = 39/368 (10%)
Query: 5 CIRCGREYPEDEIRYRC-ECGGLLEVVVDLDKVDTKIFDGNNITLWKY-ESWLP-VKKIV 61
C++C +E E +C +CGG E+++D + FD N+ + Y E P +K +
Sbjct: 10 CMKCRKER-ESIYEIKCNKCGGPFEILIDFE------FDKNSERGFPYSEKIFPYIKHFI 62
Query: 62 SLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACA 121
SL EG TPL + N+ + K + NP+GS+KDRG VS E G+K+++
Sbjct: 63 SLGEGRTPLIKKGNI---------WFKLDFLNPSGSYKDRGAVTLVSYLAEKGVKQISED 113
Query: 122 STGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIE 181
S+GN +++AAY+A AGIEAY+ VP GKL Q YGA V+ ++G+ +D V +
Sbjct: 114 SSGNAGSAIAAYSAAAGIEAYIFVPETAKG-GKLKQIESYGAHVVRVRGSRED----VAK 168
Query: 182 ASEELGIYMLNSI-NPFRLEGQKTIAYEIYDQLQ-KVPDNVVLPVGNAGNISAIWKGFKE 239
A+E G Y + + P +G +T+AYEI L K+P+ V +PV + ++KGFK
Sbjct: 169 AAENSGYYYASHVLQPQFRDGIRTLAYEIVKDLDWKIPNYVFIPVSAGTLLLGVYKGFKH 228
Query: 240 LYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWR 299
L ++GVI ++P+++ +Q E PL +K K + P ++A A+ P + +
Sbjct: 229 LLDSGVISEMPKIVAVQTEQVMPLCAKFK-KISYTPPDKVTSIADALVSTRPFLLDYMVK 287
Query: 300 AVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVL 359
A E +VSD EI++A + LA K GL VE +SA A K + VL
Sbjct: 288 ASSEC----IVVSDNEIVEAWKELA-KMGLLVEYSSATVFAAYKKYSVNDA-------VL 335
Query: 360 VTTGHGLK 367
V TG GLK
Sbjct: 336 VLTGSGLK 343
>gb|AAB40319.1| (U46200) threonine synthase [Cloning vector pDG1663]
>gi|1185597|gb|AAB40326.1| (U46201) threonine synthase
[Cloning vector pDG1664]
Length = 185
Score = 154 bits (386), Expect = 1e-36
Identities = 78/163 (47%), Positives = 112/163 (67%), Gaps = 8/163 (4%)
Query: 208 EIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAW 267
E+ +QL + PD + +PVGNAGNI+A WKGFKE +E LP+M G +AEGA+ + +
Sbjct: 1 EVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTG-LPKMRGFEAEGAAAIVRN- 58
Query: 268 KEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKE 327
+ +NPET+ATAIRIGNPA+W+KA +A EES G + V+D+EIL A +++A E
Sbjct: 59 ------EVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIARVE 112
Query: 328 GLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTGHGLKDPD 370
G+F EP S AS+AG++K + ++ + V V TG+GLKDP+
Sbjct: 113 GVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPN 155
>gb|AAG20250.1| (AE005100) threonine synthase; ThrC3 [Halobacterium sp. NRC-1]
Length = 363
Score = 153 bits (382), Expect = 4e-36
Identities = 128/384 (33%), Positives = 187/384 (48%), Gaps = 37/384 (9%)
Query: 2 VLRCIRCGREY---PEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNIT----LWKYESW 54
+L C CG Y PE+ R R E VD + D + LW + +
Sbjct: 1 MLVCRSCGATYETGPEEPWRCRA-----CEHAVDFAERPRATGDPTAVDPTAGLWAFSEF 55
Query: 55 LPVKK--IVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALE 112
LPV VSL EG TPL + + K + P+GS+KDRG V +++A
Sbjct: 56 LPVAADDAVSLGEGWTPLVSASEWDAEF-------KLDYVCPSGSYKDRGAAVLMTRAAA 108
Query: 113 LGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNF 172
LG+ RV S+GN A++A YAA+AGI+A + VP+ A KL GA +P+ G
Sbjct: 109 LGVDRVVEDSSGNAGAAVAQYAARAGIDAEIYVPADAPA-AKLDAMEAAGATTVPVAG-- 165
Query: 173 DDALRVVIEA--SEELGI---YMLNSINPFRLEGQKTIAYEIYDQL-QKVPDNVVLPVGN 226
R V EA SE +G Y ++ +P G T+AYEI Q + PD VV+PVG+
Sbjct: 166 --GRRAVTEACVSEAVGSDAWYASHAWSPSFYAGTATVAYEIAAQRGWRAPDAVVVPVGH 223
Query: 227 AGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAI 286
+ ++GF+ L G I+ +PR++G+QA G P+A A + N A I
Sbjct: 224 GTLLLGAYRGFRALAAGGWIESMPRLLGVQAAGVEPVAAAVNGSASDEDAVN--EAADGI 281
Query: 287 RIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKE-GLFVEPASAASLAGLIKL 345
+I +PA ++ AV + G ++V+ +E + + E GL+VEP SA ++AGL
Sbjct: 282 QIRSPARLDQVAAAVAATDG--DVVACDESATTDALASLHEAGLYVEPTSAVAVAGLAAY 339
Query: 346 LNEEKVDRDESFVLVTTGHGLKDP 369
V + V+ TG GLK P
Sbjct: 340 RARGVVGDSDDVVVALTGSGLKKP 363
>emb|CAC11175.1| (AL445063) threonine synthase related protein [Thermoplasma
acidophilum]
Length = 316
Score = 146 bits (366), Expect = 3e-34
Identities = 98/310 (31%), Positives = 161/310 (51%), Gaps = 21/310 (6%)
Query: 66 GGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACASTGN 125
G TP + L L + L+ K EGAN TG+ KDR V A+ G +A + GN
Sbjct: 13 GRTPTIKAYALGNKLHLNNLFLKFEGANATGTQKDRISEAHVINAMRGGYNGIAVGTCGN 72
Query: 126 TSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEE 185
AS+A +A + G+++Y+ +P + + A+++ G +++ + + + S++
Sbjct: 73 YGASIAYFAHQYGVKSYIGIPRS-YSHDRTDFMQSEQAEILYYDGKYEETVEFIRDFSKD 131
Query: 186 LGIYMLN------SINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKE 239
G+Y + SI+ TIA+EIY+ L VP V++PVGN ++ I+ GF+
Sbjct: 132 NGLYDASPGSANSSIDKMMYA---TIAFEIYEALLTVPSYVIVPVGNGTTLAGIYHGFRR 188
Query: 240 LYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPA------N 293
+Y+ GVID LPRM+G+ G +P+ +W+ + NPE + I P +
Sbjct: 189 MYDEGVIDHLPRMVGVSTSGGNPIVDSWRHGYSRVVDLNPEEIRET-SINEPLVSYRSFD 247
Query: 294 WEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDR 353
+ A A+ E+ G VSDEE++ ++ S EGL PASA+++A + L KV +
Sbjct: 248 GQDALSAIRETHGRAMYVSDEEMVYYSNLIYSAEGLNPLPASASAVAAIGHL----KVKQ 303
Query: 354 DESFVLVTTG 363
DE+ V V TG
Sbjct: 304 DETVVSVITG 313
>emb|CAC11637.1| (AL445064) threonine synthase related protein [Thermoplasma
acidophilum]
Length = 334
Score = 143 bits (356), Expect = 4e-33
Identities = 110/365 (30%), Positives = 185/365 (50%), Gaps = 39/365 (10%)
Query: 8 CGREYPEDEIRYRCECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKIVSLNEGG 67
CG++ +E+R + CG E+ T NI +++ +K ++SL E
Sbjct: 3 CGKKRVGEELRCK-SCGSPFEI-------RTGFHYRENIE----DNFPYIKNMISLGESE 50
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALEL----GMKRVACAST 123
TP++ ++ + K + PT S+KDRG + +S ++ G+ R++ S+
Sbjct: 51 TPIFHGDDFD---------LKLDYMLPTFSYKDRGSRILISHIADIRDSYGITRISEDSS 101
Query: 124 GNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEAS 183
GN AS+AAY + AG+ + VP +A K +Q YGA VI +KG+ +D ++ E S
Sbjct: 102 GNAGASIAAYGSAAGLAVDIYVPE-TVAGRKFSQIQAYGANVIKVKGSRED-VQSAAERS 159
Query: 184 EELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEA 243
E Y + + P +G +T+AYEIY Q ++P N+ +PV + ++ G + L E+
Sbjct: 160 ESF--YASHVLRPEFRDGIRTLAYEIYRQYDRMPRNIYIPVSAGTLLLGLYSGLRHLMES 217
Query: 244 GVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEE 303
G I ++P ++ +Q E SPL A + P+ ++A A+ P +K ++ + E
Sbjct: 218 GEIAEMPAIVAVQTEAVSPLC-AKINGLNYDPDNKLSSIADALVSRKPVLLQKMYQVISE 276
Query: 304 SGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
G VSD+EI++A+ LA K+G VE +SA A K E+ +LV TG
Sbjct: 277 YGRCM-TVSDDEIIEARNRLA-KKGFLVEYSSATVYAAFRK-------KPQENSLLVLTG 327
Query: 364 HGLKD 368
GLK+
Sbjct: 328 SGLKN 332
>gb|AAB40334.1| (U46202) threonine synthase [Cloning vector pDG1729]
>gi|1185614|gb|AAB40341.1| (U46203) threonine synthase
[Cloning vector pDG1731]
Length = 146
Score = 115 bits (284), Expect = 1e-24
Identities = 57/122 (46%), Positives = 84/122 (68%), Gaps = 7/122 (5%)
Query: 249 LPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESGGMF 308
LP+M G +AEGA+ + + + +NPET+ATAIRIGNPA+W+KA +A EES G
Sbjct: 2 LPKMRGFEAEGAAAIVRN-------EVIENPETIATAIRIGNPASWDKAVKAAEESNGKI 54
Query: 309 EIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTGHGLKD 368
+ V+D+EIL A +++A EG+F EP S AS+AG++K + ++ + V V TG+GLKD
Sbjct: 55 DEVTDDEILHAYQLIARVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKD 114
Query: 369 PD 370
P+
Sbjct: 115 PN 116
>pir||H72628 probable threonine synthase (EC 4.2.99.2) APE1488 [similarity] -
Aeropyrum pernix (strain K1) >gi|5105172|dbj|BAA80486.1|
(AP000061) 345aa long hypothetical threonine synthase
[Aeropyrum pernix]
Length = 345
Score = 113 bits (279), Expect = 5e-24
Identities = 121/371 (32%), Positives = 169/371 (44%), Gaps = 58/371 (15%)
Query: 3 LRCIRCGREYPEDEIRYRC-ECGGLLEVVVDLDKVDTKIFDGNNITLWKYESWLPVKKIV 61
L C RCG + E E R C C G LE V LP V
Sbjct: 14 LWCPRCGIKLREGEYRPWCPRCRGPLEAV-----------------------GLPRLPPV 50
Query: 62 SLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACA 121
L EG TPL + +YAK E NP+GSFKDRG+ + A LG V
Sbjct: 51 -LGEGSTPLVEAG--------EGVYAKLEYLNPSGSFKDRGVGYSLRMASLLGYDCVVVD 101
Query: 122 STGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIE 181
S+GNT S A Y+A+ G++A V VP G + GK A GA+++ + ++A R+ E
Sbjct: 102 SSGNTGLSTALYSARLGLKARVYVPRG-ASPGKKALIRATGAELVEAESR-EEAARLA-E 158
Query: 182 ASEELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELY 241
A E ++ + NP +EG K++ E+ + D V+ PV + + I++G +E
Sbjct: 159 AEAEKCFHVAHPTNPLFIEGVKSLGRELAGEAAGDTD-VLAPVSSGTLLLGIYRGLEE-- 215
Query: 242 EAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKN-----PETLATAIRIGNPANWEK 296
E G R++ +Q+ A L + PE L A+ + P E+
Sbjct: 216 ERGRF----RLVAVQSPAAYSL-------KGLVPELGWVGGVEGRLLDALLLARPPRLEE 264
Query: 297 AWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDES 356
RAV ESGG +V D I A R A + G VEP+SAA A ++L E+K S
Sbjct: 265 MARAVRESGGGVVVVGDGAIPGAVR-EAVQRGFLVEPSSAAVFAA-HEVLREKKWLSGRS 322
Query: 357 FVLVTTGHGLK 367
+LV TG GLK
Sbjct: 323 -LLVLTGSGLK 332
>pir||D81355 threonine dehydratase (EC 4.2.1.16) Cj0828c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968274|emb|CAB73093.1| (AL139076) threonine
dehydratase biosynthetic [Campylobacter jejuni]
Length = 403
Score = 100 bits (246), Expect = 4e-20
Identities = 83/264 (31%), Positives = 132/264 (49%), Gaps = 17/264 (6%)
Query: 84 ELYAKNEGANPTGSFKDRGMTVGVSK-ALELGMKRVACASTGNTSASLAAYAAKAGIEAY 142
E+Y KNE TG++K RG ++ + E V AS GN + +A A K I+A
Sbjct: 36 EIYLKNENLQITGAYKIRGAYNKIANLSTEQKQHGVIAASAGNHAQGVAISAKKFSIKAV 95
Query: 143 VLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEELGIYMLNSI-NPFRLEG 201
+++P L K++ GA+VI NFD+A ++E + ++ + F + G
Sbjct: 96 IVMPESTPLL-KVSATKALGAEVILRGDNFDEAYAFATSYAKENNLSFIHPFEDEFVMAG 154
Query: 202 QKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGAS 261
Q T+ E+ D++ + D ++ PVG G IS I K+ I+ ++IG+ A+GA
Sbjct: 155 QGTLMLEMLDEISDL-DMIIAPVGGGGLISGISSTAKQ------INPNIKIIGVGAKGAP 207
Query: 262 PLAKAWKEKRKFKPEKNPETLAT--AIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKA 319
+ +++ K K K K+ T+A A+R NP N+ V++ F V DEEI A
Sbjct: 208 AMYESFHAK-KIKNAKSVRTIADGIAVRDANPINFNIILECVDD----FIQVDDEEIANA 262
Query: 320 QRILASKEGLFVEPASAASLAGLI 343
L K + VE A AAS+A L+
Sbjct: 263 VLFLLEKHKIIVEGAGAASVAALL 286
>gb|AAA72079.1| (M34778) ORF; similar to threonine synthases [Methanothermus
fervidus]
Length = 98
Score = 97.5 bits (239), Expect = 2e-19
Identities = 52/97 (53%), Positives = 66/97 (67%)
Query: 297 AWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDES 356
A RA+ ES VSDEEILKAQR+LA KEG+ VEPASAAS+AGLIKL+++ +D E
Sbjct: 1 ALRAIYESNXTALXVSDEEILKAQRLLAKKEGIGVEPASAASIAGLIKLIDDGYLDHGER 60
Query: 357 FVLVTTGHGLKDPDIVLRNFKLPEPIEPTLDAFRRVI 393
V V TGH LKDP I + K P +EP + +++I
Sbjct: 61 VVCVLTGHLLKDPKIAINACKKPLEVEPDFNLLKKII 97
>sp|P05792|THD2_ECOLI THREONINE DEHYDRATASE CATABOLIC (THREONINE DEAMINASE)
>gi|68320|pir||DWECTD threonine dehydratase (EC
4.2.1.16), biodegradative [validated] - Escherichia coli
>gi|43043|emb|CAA32593.1| (X14430) tdcB gene product (AA
1 - 329) [Escherichia coli] >gi|147923|gb|AAA24660.1|
(M21312) threonine dehydratase 2 (EC 4.2.1.16)
[Escherichia coli] >gi|606058|gb|AAA57921.1| (U18997)
catabolic threonine dehydratase [Escherichia coli]
>gi|1789505|gb|AAC76152.1| (AE000393) threonine
dehydratase, catabolic [Escherichia coli K12]
>gi|228767|prf||1811219A Thr deaminase [Escherichia
coli]
Length = 329
Score = 90.1 bits (220), Expect = 4e-17
Identities = 79/284 (27%), Positives = 133/284 (46%), Gaps = 15/284 (5%)
Query: 84 ELYAKNEGANPTGSFKDRGMTVGVSKALELGMKR--VACASTGNTSASLAAYAAKAGIEA 141
E++ K E TGSFK RG +S + ++ VAC S GN + ++ A GI+
Sbjct: 43 EIFLKFENMQRTGSFKIRGAFNKLSSLTDAEKRKGVVAC-SAGNHAQGVSLSCAMLGIDG 101
Query: 142 YVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEELG-IYMLNSINPFRLE 200
V++P G K+A Y A+V+ NF+D + V E E G I++ +P +
Sbjct: 102 KVVMPKG-APKSKVAATCDYSAEVVLHGDNFNDTIAKVSEIVEMEGRIFIPPYDDPKVIA 160
Query: 201 GQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGA 260
GQ TI EI + L V DNV++P+G G I+ I K I+ R+IG+Q+E
Sbjct: 161 GQGTIGLEIMEDLYDV-DNVIVPIGGGGLIAGIAVAIKS------INPTIRVIGVQSENV 213
Query: 261 SPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQ 320
+A ++ + + TLA + P N + V E +VS++EI +
Sbjct: 214 HGMAASF-HSGEITTHRTTGTLADGCDVSRPGN--LTYEIVRELVDDIVLVSEDEIRNSM 270
Query: 321 RILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTGH 364
L + + E A A + A L+ ++ + ++ +++ G+
Sbjct: 271 IALIQRNKVVTEGAGALACAALLSGKLDQYIQNRKTVSIISGGN 314
>pir||D72386 threonine dehydratase (EC 4.2.1.16) TM0356 [similarity] -
Thermotoga maritima (strain MSB8)
>gi|4980859|gb|AAD35443.1|AE001716_6 (AE001716)
threonine dehydratase catabolic [Thermotoga maritima]
Length = 401
Score = 89.3 bits (218), Expect = 7e-17
Identities = 81/267 (30%), Positives = 126/267 (46%), Gaps = 15/267 (5%)
Query: 84 ELYAKNEGANPTGSFKDRGMTVGVSKALELGMKR-VACASTGNTSASLAAYAAKAGIEAY 142
E+Y K E TGSFK RG ++ E KR V AS GN + +A A GI A
Sbjct: 36 EIYLKMENLQKTGSFKIRGAYNKIAHLSEEERKRGVVAASAGNHAQGVALAAQIFGIPAT 95
Query: 143 VLVPSGKIALGKLAQAIIYGAKVIPIKGN-FDDALRVVIEASEELGIYMLNSIN-PFRLE 200
+++P L K+ + GA+VI ++GN FD+A + E+ G ++ N P +
Sbjct: 96 IVMPR-YAPLSKITKTRNLGAQVI-LEGNIFDEAYEAALRIQEKTGAVFVHPFNDPHVIA 153
Query: 201 GQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGA 260
GQ TI EI + L V + VV+PVG G IS + K + + ++IG+Q E
Sbjct: 154 GQGTIGLEIMEDLPDV-EVVVVPVGGGGLISGVSVAIKSM------NPEVKVIGVQTENM 206
Query: 261 SPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQ 320
+ + + R + E P TLA I + P + + V++ V++EEI A
Sbjct: 207 PSMIASLRRGRAERVEGKP-TLADGIAVKKPG--DLTFELVKKYVDEMVAVNEEEIADAI 263
Query: 321 RILASKEGLFVEPASAASLAGLIKLLN 347
L + + E A A +A ++ L+
Sbjct: 264 LFLLEQAKVVAEGAGAVGVAAVLNKLD 290
>gb|AAG20244.1| (AE005099) threonine dehydratase; IluA [Halobacterium sp. NRC-1]
Length = 495
Score = 85.8 bits (209), Expect = 8e-16
Identities = 80/279 (28%), Positives = 137/279 (48%), Gaps = 14/279 (5%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGV-SKALELGMKRVACASTGNT 126
TPL + + G ++ K E TGSFK RG T + + + + V AS GN
Sbjct: 106 TPLEYSHTFSDLTGA-DVRPKLECFQRTGSFKIRGATNRIRTLSADQQDAGVVTASAGNH 164
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEEL 186
+ +A A+++G+++ V++P + K+ YGA+V+ ++DDA E
Sbjct: 165 AQGVALAASRSGVDSKVVMPE-SAPISKIKATKSYGAEVVLHGADYDDAQAHAHELEAAE 223
Query: 187 G-IYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
G Y+ + + + GQ T+ EI V D VV+P+G G IS + K G
Sbjct: 224 GRTYVHAFDDEYIMAGQGTLGLEIAADCPTV-DTVVVPIGGGGLISGVATALK-----GE 277
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESG 305
+D + R+IG+QAEGAS +A++ +K + + + +T+A I + + + ++E
Sbjct: 278 LDDV-RVIGVQAEGASTVARS-LDKGQPQAVDHVDTIADGIAVRQVG--AQTFPVIQEHV 333
Query: 306 GMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIK 344
VSD+EI A +L + VE A A +LA +++
Sbjct: 334 DEVVTVSDDEIATALVLLLERGKTLVEGAGATALAAVLE 372
>pir||DWRTT L-serine dehydratase (EC 4.2.1.13) - rat >gi|57225|emb|CAA68721.1|
(Y00752) serine dehydratase (AA 1 - 327) [Rattus
norvegicus]
Length = 327
Score = 83.9 bits (204), Expect = 3e-15
Identities = 74/277 (26%), Positives = 125/277 (44%), Gaps = 12/277 (4%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACASTGNTS 127
TPL L K+ G ++ K + + P+GSFK RG+ + G K C+S GN
Sbjct: 11 TPLRDSMALSKVAGTS-VFLKMDSSQPSGSFKIRGIGHLCKMKAKQGCKHFVCSSAGNAG 69
Query: 128 ASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRV--VIEASEE 185
+ A A + G+ A ++VPS AL + + GA V + D+A+++ +E +
Sbjct: 70 MATAYAARRLGLPATIVVPSTTPAL-TIERLKNEGATVEVVGEMLDEAIQLAKALEKNNP 128
Query: 186 LGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
+Y+ +P EG ++ E+ + L P +VL VG G + + +G +E+ V
Sbjct: 129 GWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLSVGGGGLLCGVVQGLREVGWEDV 188
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESG 305
+I ++ GA A KE K P+ + A +G + + E
Sbjct: 189 -----PIIAMETFGAHSFHAAVKEG---KLVTLPKITSVAKALGVNTVGAQTLKLFYEHP 240
Query: 306 GMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGL 342
E++SD+E + A E + VEPA A+LA +
Sbjct: 241 IFSEVISDQEAVTAIEKFVDDEKILVEPACGAALAAV 277
>sp|P44503|THRC_HAEIN THREONINE SYNTHASE >gi|1075349|pir||H64047 threonine synthase (EC
4.2.99.2) - Haemophilus influenzae (strain Rd KW20)
>gi|1573038|gb|AAC21765.1| (U32694) threonine synthase
(thrC) [Haemophilus influenzae Rd]
Length = 425
Score = 80.8 bits (196), Expect = 3e-14
Identities = 89/338 (26%), Positives = 144/338 (42%), Gaps = 48/338 (14%)
Query: 76 LEKILGVKELYAKNEGANPTGSFKDRG---MTVGVSKALELGMKRVACASTGNTSASLA- 131
LEK+ + +YA PT +FKD G M ++ G + A++G+T A++A
Sbjct: 84 LEKV--EENIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKITILTATSGDTGAAVAH 141
Query: 132 AYAAKAGIEAYVLVPSGKIA--LGKLAQAIIYGAKVIPIKGNFDDALRVV------IEAS 183
A+ I +L P GKI+ KL + + + I +FD +V +E
Sbjct: 142 AFYGLENINVVILYPKGKISPLQEKLFCTLGGNIRTVAINADFDACQALVKQAFDDVELR 201
Query: 184 EELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVP-DNVV--LPVGNAGNISAIWKGFKEL 240
+ +G+ NSIN RL Q +E QL K DNVV +P GN GN++
Sbjct: 202 QAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVVVSVPSGNFGNLT--------- 252
Query: 241 YEAGVIDK---LPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEK- 296
AG+I K LP + + A+ + + + P+ TL+ A+ + P NW +
Sbjct: 253 --AGLIAKTLGLPIKRFVASTNANDTVPRYLKSGNWDPKTTVATLSNAMDVSRPNNWPRV 310
Query: 297 -------AWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEE 349
W + GM E+ LKA + +G EP A + L ++
Sbjct: 311 EELFKRNGWDLTDLGSGMLSDSETEDTLKAMQ----SKGYLCEPHGAIAYQVL-----KD 361
Query: 350 KVDRDESFVLVTTGHGLKDPDIVLRNFKLPEPIEPTLD 387
++ E+ + + T H K + V R + P+ TLD
Sbjct: 362 QLKASETGIFLCTAHPAKFKESVERILGIQLPLPETLD 399
>gi|11345492 serine racemase [Homo sapiens] >gi|10434972|dbj|BAB14442.1|
(AK023169) unnamed protein product [Homo sapiens]
>gi|11034785|gb|AAG27081.1|AF169974_1 (AF169974) serine
racemase [Homo sapiens]
Length = 340
Score = 80.4 bits (195), Expect = 3e-14
Identities = 82/285 (28%), Positives = 130/285 (44%), Gaps = 25/285 (8%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSK----ALELGMKRVACAST 123
TP+ + L ++ G + L+ K E TGSFK RG V ALE K V S+
Sbjct: 26 TPVLTSSILNQLTG-RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84
Query: 124 GNTSASLAAYAAKAGIEAYVLVPSGKIALGKLA-QAIIYGAKVIPIKGNFDDALRVVIEA 182
GN +L A GI AY++VP KLA QA YGA ++ + + + V
Sbjct: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA--YGASIVYCEPSDESRENVAKRV 142
Query: 183 SEEL-GIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELY 241
+EE GI + + P + GQ TIA E+ +Q+ V D +V+PVG G ++ I
Sbjct: 143 TEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV-DALVVPVGGGGMLAGI-------- 193
Query: 242 EAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKN---PETLATAIRIGNPANWEKAW 298
A + L + + A S ++ K K K N PET+A ++ N W
Sbjct: 194 -AITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLN---TW 249
Query: 299 RAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLI 343
+ + V+++EI A +++ + L +EP + +A ++
Sbjct: 250 PIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVL 294
>gb|AAK40587.1| Threonine dehydratase catabolic (threonine deaminase) (tdcB)
[Sulfolobus solfataricus]
Length = 405
Score = 79.6 bits (193), Expect = 6e-14
Identities = 78/281 (27%), Positives = 129/281 (45%), Gaps = 22/281 (7%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKR----VACAST 123
TP+ +I+ K +Y K E TGSFK RG +K L L + V S
Sbjct: 24 TPIDYSTTFSRIINAK-VYLKLENLQKTGSFKVRG---AFNKLLSLKEEEKKNGVIAVSA 79
Query: 124 GNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEAS 183
GN + +A A+ I++ +++P A LA YGA+V+ ++++ E
Sbjct: 80 GNHAQGVAYAASTLNIKSTIVMPETAPASKYLATK-SYGAEVVLYGKYLHESMKKAEELI 138
Query: 184 EELGIYMLNSINPFR-LEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYE 242
+ G+ ++ + + GQ TI E+YD PD V++P+G G IS I K +
Sbjct: 139 QNTGLIFVHPYSDLDVITGQGTIGLELYD---IEPDYVIIPIGGGGLISGISIALKYRFP 195
Query: 243 AGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVE 302
++IG+Q+ +SP K K+ + + ++A I + +P+ E + +
Sbjct: 196 N------VKIIGVQS-SSSPSMKVSKDLGRLVEIEPSYSIADGILVKSPS--ELTFSIIN 246
Query: 303 ESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLI 343
E +V DEEI +A +L + E A AA+LA LI
Sbjct: 247 ELVDDIVLVDDEEIAEAIVLLLERSKTLAEGAGAAALASLI 287
>emb|CAC11260.1| (AL445063) probable threonine dehydratase, biodegradative
[Thermoplasma acidophilum]
Length = 406
Score = 78.8 bits (191), Expect = 1e-13
Identities = 87/321 (27%), Positives = 136/321 (42%), Gaps = 18/321 (5%)
Query: 51 YESWLPVKKIVSLNEGGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKA 110
YE L K + TPL + G E+Y K E TGSFK RG SK
Sbjct: 9 YEDILSAKAYLEGRINRTPLIKSTTFGNEYG-SEMYFKLENFQKTGSFKSRGALFKFSKL 67
Query: 111 LELGMKRVACASTGNTSASLAAYAAKA-GIEAYVLVPSGKIALGKLAQAIIYGAKVIPIK 169
E +R ++ A AYAAK GI A +++P I K+ YGA+VI
Sbjct: 68 SEDDRRRGVLTASAGNHAQGVAYAAKVNGINAKIVMPEYTIP-QKVNAVAGYGAEVILHG 126
Query: 170 GNFDDALRVVIEASEELGIYMLNSINP-FRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAG 228
++D+A R + + + + + N + + GQ TI EI + + D +++PVG G
Sbjct: 127 FDYDEAHRYADDLARKENRVFIEAFNDRWVISGQGTIGLEIMEDRPDI-DTIIVPVGGGG 185
Query: 229 NISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRI 288
IS I K + R+IGI++E S KA + K + ++ I +
Sbjct: 186 LISGIALAAKH------HNPHVRIIGIESE-LSDSMKASLREGKIVAHTSGVSICDGISV 238
Query: 289 GNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNE 348
P + + ++ V++E + KA L + + EP+ A LA ++ E
Sbjct: 239 KYPG--DLTFNIAKDYVDDIVTVTEESVSKAIYRLFERMKIVAEPSGAVGLAAIM----E 292
Query: 349 EKVDRDESFVLVTTGHGLKDP 369
KVD V + G +P
Sbjct: 293 GKVDVKGRKVAIVVSGGNINP 313
>pir||T04211 probable threonine dehydratase (EC 4.2.1.16) T5C23.70 [similarity]
- Arabidopsis thaliana >gi|4539455|emb|CAB39935.1|
(AL049500) putative protein [Arabidopsis thaliana]
>gi|7267864|emb|CAB78207.1| (AL161532) putative protein
[Arabidopsis thaliana]
Length = 346
Score = 78.0 bits (189), Expect = 2e-13
Identities = 80/292 (27%), Positives = 133/292 (45%), Gaps = 17/292 (5%)
Query: 56 PVKKIVSLNE--GGTPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGV-SKALE 112
PV SLN G + ++ L+K + + Y + +G+FK RG V S E
Sbjct: 30 PVLTSESLNSISGRSLFFKCECLQKGIECRSFYF-SVYCGKSGAFKFRGACNAVLSLDAE 88
Query: 113 LGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNF 172
K V S+GN +A+L+ A GI AY++VP G K+ I YG KVI +
Sbjct: 89 QAAKGVVTHSSGNHAAALSLAAKIQGIPAYIVVPKGAPKC-KVDNVIRYGGKVIWSEATM 147
Query: 173 DDALRVVIEASEELGIYMLNSINPFR-LEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNIS 231
+ + +E G +++ N R + GQ TIA E+ +Q+Q++ D +V+P+ G IS
Sbjct: 148 SSREEIASKVLQETGSVLIHPYNDGRIISGQGTIALELLEQIQEI-DAIVVPISGGGLIS 206
Query: 232 AIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNP 291
+ K I R+I + +GA A++ K K T+A +R
Sbjct: 207 GVALAAKS------IKPSIRIIAAEPKGADDAAQS-KVAGKIITLPVTNTIADGLR---A 256
Query: 292 ANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLI 343
+ + W V + + + EI++A ++ + VEP+ A LA ++
Sbjct: 257 SLGDLTWPVVRDLVDDVVTLEECEIIEAMKMCYEILKVSVEPSGAIGLAAVL 308
>gb|AAF54364.1| (AE003682) CG8129 gene product [alt 1] [Drosophila melanogaster]
Length = 469
Score = 77.6 bits (188), Expect = 2e-13
Identities = 77/263 (29%), Positives = 118/263 (44%), Gaps = 15/263 (5%)
Query: 84 ELYAKNEGANPTGSFKDRGMTVG-VSKALELGMKRVACASTGNTSASLAAYAAKAGIEAY 142
ELY K + TGSFK+RG +S E V AS GN + +L + K I
Sbjct: 92 ELYLKKDFLQYTGSFKERGARYALLSLTEEQKRTGVISASLGNHAQALCYHGWKLNIPVT 151
Query: 143 VLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEELGIYMLNSI-NPFRLEG 201
V++P + K+ + Y A+VI + +A + + S E G+ +N +P + G
Sbjct: 152 VVMPKA-APIMKIQKCRNYKARVIVDGNDMGEAKSLAMRMSREEGLLYVNGYDHPHIMAG 210
Query: 202 QKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGAS 261
Q TI EI +Q+ + PD VV+PVG G I+ I K L ++IG+++E +
Sbjct: 211 QGTIGLEILEQVPE-PDAVVVPVGGGGLIAGIATAVKAL------SPKTKIIGVESEKCA 263
Query: 262 PLAKAWKEKRKF-KPEKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQ 320
+A + P KN TLA + + P A+ +V +E I A
Sbjct: 264 SFTRAMENDGPIHTPIKN--TLADGLAV--PKVGYNAYATAMPLIDRMVVVKEEWIAVAI 319
Query: 321 RILASKEGLFVEPASAASLAGLI 343
L +E VE A A LA ++
Sbjct: 320 LRLVEEEKCVVEGAGGAGLAAIL 342
>pir||C72630 probable threonine dehydratase APE1498 - Aeropyrum pernix (strain
K1) >gi|5105183|dbj|BAA80497.1| (AP000061) 349aa long
hypothetical threonine dehydratase [Aeropyrum pernix]
Length = 349
Score = 77.3 bits (187), Expect = 3e-13
Identities = 72/266 (27%), Positives = 131/266 (49%), Gaps = 16/266 (6%)
Query: 101 RGMTVGVSKALELG-MKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAI 159
RG + +ALE G ++ V AS GN + +A A+ G+++ +++P K+
Sbjct: 2 RGPLFKLGRALEKGSVEGVVAASAGNHAQGVAYAASFYGLKSVIVMPE-LAPPAKVKATR 60
Query: 160 IYGAKVIPIKGNFDDALRVVIEASEELGIYMLNSIN-PFRLEGQKTIAYEIYDQLQKVPD 218
YGA+V+ D+A ++ + +EE G +++ + P + G TIA+E Y+Q K D
Sbjct: 61 SYGAEVVLHGRVVDEAFKLAEKIAEERGYMLVHPFDDPEIMAGNGTIAWEAYEQGGKF-D 119
Query: 219 NVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKN 278
V++PVG G IS + ++L GV ++IG++AE A +++KE + + E
Sbjct: 120 TVIVPVGGGGLISGVVSVVRKLMP-GV-----KVIGVEAEAAPKFVESFKEGKPIEVEVT 173
Query: 279 PETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAAS 338
+LA + P + V+ V + EI A +L + + E A AA
Sbjct: 174 -HSLADGLVTKKPG--RLTYPIVKHLVDKVVAVDEHEIASAMYLLLERSKILAEGAGAAG 230
Query: 339 LAGLIKLLNEEKVDRDESFVLVTTGH 364
+A L+ + + K ++ V+V+ G+
Sbjct: 231 VAALLARVVKPK---GKTLVIVSGGN 253
>pir||B82634 threonine dehydratase catabolic XF1819 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9106898|gb|AAF84625.1|AE004003_4 (AE004003)
threonine dehydratase catabolic [Xylella fastidiosa]
Length = 380
Score = 76.9 bits (186), Expect = 4e-13
Identities = 80/266 (30%), Positives = 123/266 (46%), Gaps = 20/266 (7%)
Query: 88 KNEGANPTGSFKDRGMTVGVSKALELGMKR-VACASTGNTSASLAAYAAKAGIEAYVLVP 146
K E TGS+K RG + ALE G R V CAS GN + +A A + GI+A ++P
Sbjct: 84 KLENLQRTGSYKVRGALNAMLVALERGDNRPVICASAGNHAQGVAWSAYRLGIQAITVMP 143
Query: 147 SGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEELGIYMLNSI-NPFRLEGQKTI 205
G + K+A +GA V ++D+A E +E+ + L++ +P + GQ T+
Sbjct: 144 HG-APVTKVAGVSHWGATVRQHGQSYDEAYAFACELAEQNDYHFLSAFDDPDVIAGQGTV 202
Query: 206 AYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAK 265
EI PD V++P+G G S I L GV R+IG Q EG +A+
Sbjct: 203 GIEI---TAHEPDVVIVPIGGGGLASGI---ALVLRSQGV-----RVIGAQVEGVDAMAR 251
Query: 266 AWK-EKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILA 324
A + + R+ P TLA +++ P + R IV + E+ + L
Sbjct: 252 AIRGDTREIAP---VSTLADGVKVKIPGFITR--RLCANLLDDVVIVREAELRETLVRLV 306
Query: 325 SKEGLFVEPASAASLAGLIKLLNEEK 350
+E L E A A +LA ++ + K
Sbjct: 307 LEEHLIAEGAGALALAAGRRVAGKRK 332
>gi|7305521 serine racemase [Mus musculus] >gi|6448865|gb|AAF08701.1|AF148321_1
(AF148321) serine racemase [Mus musculus]
Length = 339
Score = 75.7 bits (183), Expect = 9e-13
Identities = 80/285 (28%), Positives = 129/285 (45%), Gaps = 25/285 (8%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKAL----ELGMKRVACAST 123
TP+ + L +I G + L+ K E TGSFK RG + + E K V S+
Sbjct: 26 TPVLTSSILNQIAG-RNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEEKPKAVVTHSS 84
Query: 124 GNTSASLAAYAAKAGIEAYVLVPSGKIALGKLA-QAIIYGAKVIPIKGNFDDALRVVIEA 182
GN +L A GI AY++VP KLA QA YGA ++ + + +V
Sbjct: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQA--YGASIVYCDPSDESREKVTQRI 142
Query: 183 SEEL-GIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELY 241
+E GI + + P + GQ TIA E+ +Q+ V D +V+PVG G ++ I
Sbjct: 143 MQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLV-DALVVPVGGGGMVAGI-------- 193
Query: 242 EAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKN---PETLATAIRIGNPANWEKAW 298
A I L + + A S ++ K K + N PET+A ++ N W
Sbjct: 194 -AITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLN---TW 249
Query: 299 RAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLI 343
+ + V+++EI A +++ + L +EP + +LA ++
Sbjct: 250 PIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVL 294
>sp|Q02145|THD1_LACLA THREONINE DEHYDRATASE BIOSYNTHETIC (THREONINE DEAMINASE)
>gi|486733|pir||S35141 probable threonine dehydratase
(EC 4.2.1.16) - Lactococcus lactis subsp. lactis
Length = 441
Score = 74.5 bits (180), Expect = 2e-12
Identities = 87/317 (27%), Positives = 147/317 (45%), Gaps = 39/317 (12%)
Query: 50 KYESWLPVKKIVSLNEGGTPLYRLNNLEKILGVK---ELYAKNEGANPTGSFKDRGMTVG 106
KY++ + +K++V+ TPL L+ L K +Y K E SFK RG
Sbjct: 32 KYQANIYLKEVVTK----TPL----QLDPYLSNKYQANIYLKEENLQKVRSFKLRGAYYS 83
Query: 107 VSKAL-ELGMKRVACASTGNTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKV 165
+SK E K V CAS GN + +A A + I A + +P K++Q +G
Sbjct: 84 ISKLSDEQRSKGVVCASAGNHAQGVAFAANQLNISATIFMPV-TTPNQKISQVKFFGESH 142
Query: 166 IPIK---GNFDDALRVVIEASEELGIYMLNSINPFR----LEGQKTIAYEIYDQLQKVP- 217
+ I+ FD++ R S++ I+PF + GQ T+A EI+ Q +K
Sbjct: 143 VTIRLIGDTFDESARAAKAFSQDND---KPFIDPFDDENVIAGQGTVALEIFAQAKKQGI 199
Query: 218 --DNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKP 275
D + + +G G I+ I KE Y +IG++A+GA+ + A+ +
Sbjct: 200 SLDKIFVQIGGGGLIAGITAYSKERYPQ------TEIIGVEAKGATSMKAAYSAGQPVTL 253
Query: 276 EKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILA--SKEGLFVEP 333
E + + A I + +K ++ + + + ++++ +E L +Q IL SK G+ EP
Sbjct: 254 E-HIDKFADGIAVATVG--QKTYQLINDK--VKQLLAVDEGLISQTILELYSKLGIVAEP 308
Query: 334 ASAASLAGLIKLLNEEK 350
A A S+A L + +E K
Sbjct: 309 AGATSVAALELIKDEIK 325
>pir||F82086 threonine synthase VC2362 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9656931|gb|AAF95505.1| (AE004306)
threonine synthase [Vibrio cholerae]
Length = 426
Score = 74.5 bits (180), Expect = 2e-12
Identities = 91/332 (27%), Positives = 144/332 (42%), Gaps = 45/332 (13%)
Query: 79 ILGVKE-LYAKNEGANPTGSFKDRG---MTVGVSKALELGMKRVACASTGNTSASLA-AY 133
I VKE +YA PT +FKD G M ++ G + A++G+T A++A A+
Sbjct: 84 IAKVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVSNGGKITILTATSGDTGAAVAHAF 143
Query: 134 AAKAGIEAYVLVPSGKIA--LGKLAQAIIYGAKVIPIKGNFDDALRVVIEA------SEE 185
I +L P GKI+ KL + + I G+FD +V +A ++
Sbjct: 144 YGMPDINVVILYPKGKISPLQEKLFCTLGKNIHTVAINGDFDACQALVKQAFDDAELRQQ 203
Query: 186 LGIYMLNSINPFRLEGQKTIAYEIYDQLQKVP-DNVVL--PVGNAGNISAIWKGFKELYE 242
+G+ NSIN RL Q +E Q+ K +N+V+ P GN GN++A
Sbjct: 204 IGLNSANSINISRLMAQICYYFEAAAQMSKAERENLVISVPSGNFGNLTA---------- 253
Query: 243 AGVIDK---LPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWR 299
G++ K LP I A A+ + E +++P+ T + A+ + P NW +
Sbjct: 254 -GLLAKALGLPVKRFIAATNANDTVPRYLETGRWEPKPTVATTSNAMDVSQPNNWPRIEE 312
Query: 300 AVEESGGMFE-----IVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRD 354
+ G E VSDEE +A + L G EP + + L EE+
Sbjct: 313 LCQRMGWGLETLGKGAVSDEESAQAVQELYDL-GYLCEPHGSIAYRVL-----EEQRQPQ 366
Query: 355 ESFVLVTTGHGLK----DPDIVLRNFKLPEPI 382
E+ + + T H K DI+ + LP P+
Sbjct: 367 ETGLFLCTAHPAKFKEVVDDILGTDIALPAPL 398
>sp|P57289|THRC_BUCAI THREONINE SYNTHASE >gi|10038874|dbj|BAB12909.1| (AP001118)
threonine synthase [Buchnera sp. APS]
Length = 429
Score = 74.1 bits (179), Expect = 3e-12
Identities = 88/341 (25%), Positives = 140/341 (40%), Gaps = 51/341 (14%)
Query: 78 KILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKR----VACASTGNTSASLA-A 132
KI K+++ PT +FKD G L L K + A++G+T A++A A
Sbjct: 87 KIKITKDIHCFELFHGPTLAFKDFGARFMAQMILLLNKKNESVTILTATSGDTGAAVANA 146
Query: 133 YAAKAGIEAYVLVPSGKIA--LGKLAQAIIYGAKVIPIKGNFDDALRVVIEA------SE 184
+ + +L P GKI+ KL + K I I G+FDD ++V EA E
Sbjct: 147 FYGMKNVRVIILYPKGKISELQEKLFCTLGRNIKTISINGSFDDCQKLVKEAFNDKKLKE 206
Query: 185 ELGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDN---VVLPVGNAGNISAIWKGFKELY 241
+G+ NSIN RL Q +E + + + + +P GN GN++A
Sbjct: 207 SIGLNSANSINISRLLAQICYYFEAFSLISEEQRKNLVIAVPCGNFGNLTA--------- 257
Query: 242 EAGVIDK---LPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANW---- 294
G++ K LP I A+ + + P+K T++ A+ I P NW
Sbjct: 258 --GLLSKSLGLPIKSFIACTNANDTVPRFLNNGTWNPKKTVSTISNAMDISQPNNWTRIE 315
Query: 295 ----EKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEK 350
K W + G + EE LK K G EP +A + L ++
Sbjct: 316 ELFYRKKWDLKKLRFGSVSDHTTEETLKE----LFKLGYVSEPHAAIAYR-----LLRDQ 366
Query: 351 VDRDESFVLVTTGHGLKDPDIV---LRN-FKLPEPIEPTLD 387
+ +E + + T H K + V L+N LP ++ +D
Sbjct: 367 LKENEFGLFLGTAHPAKFKNTVEKILKNKISLPSELQNRID 407
>gi|5803161 serine dehydratase [Homo sapiens] >gi|134386|sp|P20132|SDHL_HUMAN
L-SERINE DEHYDRATASE (L-SERINE DEAMINASE)
>gi|68314|pir||DWHUT L-serine dehydratase (EC 4.2.1.13)
- human >gi|338030|gb|AAA36604.1| (J05037) serine
dehydratase (EC 4.2.1.13) [Homo sapiens]
Length = 328
Score = 73.4 bits (177), Expect = 4e-12
Identities = 71/277 (25%), Positives = 119/277 (42%), Gaps = 12/277 (4%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRVACASTGNTS 127
TP+ L K+ G +Y K + A P+GSFK RG+ + + G C+S GN
Sbjct: 11 TPIRDSMALSKMAGTS-VYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAG 69
Query: 128 ASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDA--LRVVIEASEE 185
+ A A + G+ A ++VP AL + + GA + D+A L + +
Sbjct: 70 MAAAYAARQLGVPATIVVPGTTPAL-TIERLKNEGATCKVVGELLDEAFELAKALAKNNP 128
Query: 186 LGIYMLNSINPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
+Y+ +P EG +I E+ + L + P + L VG G + + +G +E V
Sbjct: 129 GWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQECGWGDV 188
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESG 305
+I ++ GA A K P+ + A +G +A + +E
Sbjct: 189 -----PVIAMETFGAHSFHAA---TTAGKLVSLPKITSVAKALGVKTVGSQALKLFQEHP 240
Query: 306 GMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGL 342
E++SD+E + A E + VEPA A+LA +
Sbjct: 241 IFSEVISDQEAVAAIEKFVDDEKILVEPAWGAALAAV 277
>gb|AAA67575.1| (M87049) threonine deaminase [Escherichia coli]
Length = 514
Score = 72.6 bits (175), Expect = 7e-12
Identities = 80/309 (25%), Positives = 135/309 (42%), Gaps = 24/309 (7%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRG---MTVGVSKALELGMKRVACASTG 124
TPL ++ L L + K E P SFK RG M G+++ E V AS G
Sbjct: 32 TPLQKMEKLSSRLD-NVILVKREDRQPVHSFKLRGAYAMMAGLTE--EQKAHGVITASAG 88
Query: 125 NTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASE 184
N + +A +A+ G++A +++P+ + K+ +G +V+ NFD+A R IE S+
Sbjct: 89 NHAQGVAFSSARLGVKALIVMPTATADI-KVDAVXGFGGEVLLHGANFDEAKRKAIELSQ 147
Query: 185 ELGIYMLNSI-NPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEA 243
+ G + +P + GQ T+A E+ Q + D V +PVG G + + K+L
Sbjct: 148 QQGFTWVPPFDHPMVIAGQGTLALELLQQDAHL-DRVFVPVGGGGLAAGVAVLIKQLMPQ 206
Query: 244 GVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEE 303
++I ++AE ++ L A P P A + ++ +R +E
Sbjct: 207 ------IKVIAVEAEDSACLKAALDAGH---PVDLPRVGLFAEGVAVKRIGDETFRLCQE 257
Query: 304 SGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
V + I A + L EP+ A +LAG+ K + + R E + +G
Sbjct: 258 YLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIALHNI-RGERLAHILSG 316
Query: 364 -----HGLK 367
HGL+
Sbjct: 317 ANVNFHGLR 325
>gb|AAB81922.1| (U92974) IlvA [Lactococcus lactis]
Length = 416
Score = 72.6 bits (175), Expect = 7e-12
Identities = 77/279 (27%), Positives = 129/279 (45%), Gaps = 28/279 (10%)
Query: 85 LYAKNEGANPTGSFKDRGMTVGVSKAL-ELGMKRVACASTGNTSASLAAYAAKAGIEAYV 143
+Y K E SFK RG +SK E K V CAS GN + +A A + I A +
Sbjct: 37 IYLKEENLQKVRSFKLRGAYYSISKLSDEQRSKGVVCASAGNHAQGVAFAANQLNISATI 96
Query: 144 LVPSGKIALGKLAQAIIYGAKVIPIK---GNFDDALRVVIEASEELGIYMLNSINPFR-- 198
+P K++Q +G + I+ FD++ R S++ I+PF
Sbjct: 97 FMPV-TTPNQKISQVKFFGESHVTIRLIGDTFDESARAAKAFSQDND---KPFIDPFDDE 152
Query: 199 --LEGQKTIAYEIYDQLQKVP---DNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMI 253
+ GQ T+A EI+ Q +K D + + +G G I+ I KE Y +I
Sbjct: 153 NVIAGQGTVALEIFAQAKKQGISLDKIFVQIGGGGLIAGITAYSKERYPQ------TEII 206
Query: 254 GIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSD 313
G++A+GA+ + A+ + E + + A I + +K ++ + + + ++++
Sbjct: 207 GVEAKGATSMKAAYSAGQPVTLE-HIDKFADGIAVATVG--QKTYQLINDK--VKQLLAV 261
Query: 314 EEILKAQRILA--SKEGLFVEPASAASLAGLIKLLNEEK 350
+E L +Q IL SK G+ EPA A S+A L + +E K
Sbjct: 262 DEGLISQTILELYSKLGIVAEPAGATSVAALELIKDEIK 300
>gb|AAA24014.1| (K03503) threonine dehydratase [Escherichia coli]
Length = 514
Score = 72.2 bits (174), Expect = 1e-11
Identities = 80/309 (25%), Positives = 136/309 (43%), Gaps = 24/309 (7%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRG---MTVGVSKALELGMKRVACASTG 124
TPL ++ L L + K E P SFK RG M G+++ E V AS G
Sbjct: 32 TPLQKMEKLSSRLD-NVILVKREDRQPVHSFKLRGAYAMMAGLTE--EQKAHGVITASAG 88
Query: 125 NTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASE 184
N + +A +A+ G++A +++P+ + K+ + +G +V+ NFD+A R IE S+
Sbjct: 89 NHAQGVAFSSARLGVKALIVMPTATADI-KVDRLRGFGGEVLLHGANFDEAKRKAIELSQ 147
Query: 185 ELGIYMLNSI-NPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEA 243
+ G + +P + GQ T+A E+ Q + D V +PVG G + + K+L
Sbjct: 148 QQGFTWVPPFDHPMVIAGQGTLALELLQQDAHL-DRVFVPVGGGGLAACVAVLIKQLMPQ 206
Query: 244 GVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEE 303
++I ++AE ++ L A P P A + ++ +R +E
Sbjct: 207 ------IKVIAVEAEDSACLKAALDAGH---PVDLPRVGLFAEGVAVKRIGDETFRLCQE 257
Query: 304 SGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
V + I A + L EP+ A +LAG+ K + + R E + +G
Sbjct: 258 YLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIALHNI-RGERLAHILSG 316
Query: 364 -----HGLK 367
HGL+
Sbjct: 317 ANVNFHGLR 325
>gb|AAA24024.1| (M32253) ilvA [Escherichia coli]
Length = 514
Score = 71.8 bits (173), Expect = 1e-11
Identities = 80/309 (25%), Positives = 135/309 (42%), Gaps = 24/309 (7%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRG---MTVGVSKALELGMKRVACASTG 124
TPL ++ L L + K E P SFK RG M G+++ E V AS G
Sbjct: 32 TPLQKMEKLSSRLD-NVILVKREDRQPVHSFKLRGAYAMMAGLTE--EQKAHGVITASAG 88
Query: 125 NTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASE 184
N + +A +A+ G++A +++P+ + K+ +G +V+ NFD+A IE S+
Sbjct: 89 NHAQGVAFSSARLGVKALIVMPTATADI-KVDAVRGFGGEVLLHGANFDEAKAKAIELSQ 147
Query: 185 ELGIYMLNSI-NPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEA 243
+ G + +P + GQ T+A E+ Q + D V +PVG G + + K+L
Sbjct: 148 QQGFTWVPPFDHPMVIAGQGTLALELLQQDAHL-DRVFVPVGGGGLAAGVAVLIKQLMPQ 206
Query: 244 GVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEE 303
++I ++AE ++ L A P P A +G ++ +R +E
Sbjct: 207 ------IKVIAVEAEDSACLKAALDAGH---PVDLPRVGLFAEGVGVKRIGDETFRLCQE 257
Query: 304 SGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
V + I A + L EP+ A +LAG+ K + + R E + +G
Sbjct: 258 YLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIALHNI-RGERLAHILSG 316
Query: 364 -----HGLK 367
HGL+
Sbjct: 317 ANVNFHGLR 325
>sp|Q10766|THD1_MYCTU PROBABLE THREONINE DEHYDRATASE BIOSYNTHETIC (THREONINE DEAMINASE)
>gi|7436925|pir||D70763 threonine dehydratase (EC
4.2.1.16) ilvA [similarity] - Mycobacterium tuberculosis
(strain H37RV) >gi|1403483|emb|CAA98332.1| (Z74020) ilvA
[Mycobacterium tuberculosis]
Length = 429
Score = 71.8 bits (173), Expect = 1e-11
Identities = 79/288 (27%), Positives = 122/288 (41%), Gaps = 26/288 (9%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGM-TVGVSKALELGMKRVACASTGNT 126
TPL + L I G +Y K E S+K RG + V + E V C+S GN
Sbjct: 36 TPLQPSDRLSAITGAT-VYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNH 94
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPI---KGNFDDALRVVIEAS 183
+ A G+ V VP+ K K + +G + I + +D A +E
Sbjct: 95 AQGFAYACRCLGVHGRVYVPA-KTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDV 153
Query: 184 EELGIYMLNSINPFR-LEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYE 242
E G ++ + R + GQ TIA E+ QL+ PD VV+PVG G I+ I E
Sbjct: 154 ERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTT 213
Query: 243 AGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKA----W 298
+ +G++ GA+ + A P TL + + A +A +
Sbjct: 214 NTAV------LGVEPAGAAAMMAA-------LAAGEPVTLDHVDQFVDGAAVNRAGTLTY 260
Query: 299 RAVEESGGMFEIVSDEE--ILKAQRILASKEGLFVEPASAASLAGLIK 344
A+ +G M + + +E + A L EG+ EPA A S+AGL++
Sbjct: 261 AALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLE 308
>sp|Q04513|THD1_CORGL THREONINE DEHYDRATASE BIOSYNTHETIC (THREONINE DEAMINASE)
>gi|421595|pir||A47044 threonine dehydratase (EC
4.2.1.16) - Corynebacterium glutamicum
>gi|144983|gb|AAA23303.1| (L01508) threonine dehydratase
[Corynebacterium glutamicum]
Length = 436
Score = 71.0 bits (171), Expect = 2e-11
Identities = 79/294 (26%), Positives = 125/294 (41%), Gaps = 39/294 (13%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRG-MTVGVSKALELGMKRVACASTGNT 126
TPL L + G E+Y K E S+K RG + G E + AS GN
Sbjct: 40 TPLQYCPRLSEETGA-EIYLKREDLQDVRSYKIRGALNSGAQSPQEQRDAGIVAASAGNH 98
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIK---GNFDDALRVVIEAS 183
+ +A G++ + VP + K + +++G + + + NFD+A E +
Sbjct: 99 AQGVAYVCKSLGVQGRIYVPV-QTPKQKRDRIMVHGGEFVSLVVTGNNFDEASAAAHEDA 157
Query: 184 EELGIYMLNSINPFRLE----GQKTIAYEIYDQLQ---KVPDNVVLPVGNAGNISAIWKG 236
E G + I PF GQ T+A EI QL K D+V++PVG G ++ +
Sbjct: 158 ERTGATL---IEPFDARNTVIGQGTVAAEILSQLTSMGKSADHVMVPVGGGGLLAGV--- 211
Query: 237 FKELYEAGVIDKLPR--MIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANW 294
+ + D PR ++GI+ GA+ + A P TL T + A
Sbjct: 212 -----VSYMADMAPRTAIVGIEPAGAASMQAALHNG-------GPITLETVDPFVDGAEV 259
Query: 295 EKA----WRAVEESGGMFEIVSDEE--ILKAQRILASKEGLFVEPASAASLAGL 342
++ + VE++ G ++S E + L EG+ EPA A S+AGL
Sbjct: 260 KRVGDLNYTIVEKNQGRVHMMSATEGAVCTEMLDLYQNEGIIAEPAGALSIAGL 313
>emb|CAB39589.1| (AL049478) putative threonine dehydratase biosynthetic
[Mycobacterium leprae]
Length = 427
Score = 71.0 bits (171), Expect = 2e-11
Identities = 76/286 (26%), Positives = 121/286 (41%), Gaps = 22/286 (7%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGM-TVGVSKALELGMKRVACASTGNT 126
TPL + L I G +Y K E S+K RG + V E V C+S GN
Sbjct: 33 TPLQLSDRLSAITGAA-VYLKREDLQTVRSYKLRGAYNLLVQLTDEEIAAGVVCSSAGNH 91
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPI---KGNFDDALRVVIEAS 183
+ +A G+ V VP+ K K + +G I + + +D A ++
Sbjct: 92 AQGVAYACRSLGVHGRVYVPA-KTPKQKWDRIRYHGGAFIELIVGRSTYDLAAAAAVDDI 150
Query: 184 EELGIYMLNSINPFR-LEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYE 242
E G ++ + R + GQ TIA E+ +QL PD VV+PVG G I+ + E
Sbjct: 151 ERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTEPDLVVVPVGGGGCIAGMTTYLAERTA 210
Query: 243 AGVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETL--ATAIRIGNPANWEKAWRA 300
+ +G++ GA+ + A + + + A R+G + A
Sbjct: 211 NTAV------LGVEPAGAAAMMAALAAGEPVTLDYVDQFVDGAAVNRVGT-----LPYAA 259
Query: 301 VEESGGMFEIVSDEE--ILKAQRILASKEGLFVEPASAASLAGLIK 344
+ +G M I + +E + A L EG+ EPA A S+AGL++
Sbjct: 260 LTAAGDMVSITTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLE 305
>sp|P46493|THD1_HAEIN THREONINE DEHYDRATASE BIOSYNTHETIC (THREONINE DEAMINASE)
>gi|1573745|gb|AAC22398.1| (U32757) threonine deaminase
(ilvA) [Haemophilus influenzae Rd]
Length = 513
Score = 70.2 bits (169), Expect = 4e-11
Identities = 72/290 (24%), Positives = 133/290 (45%), Gaps = 20/290 (6%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSK-ALELGMKRVACASTGNT 126
TPL ++ L + L ++ K E P SFK RG +S + E V AS GN
Sbjct: 33 TPLQKMGKLSERLH-NNIWIKREDRQPVNSFKLRGAYAMISSLSAEQKAAGVIAASAGNH 91
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEEL 186
+ +A A + G++A +++P ++ K+ +G +V+ NFD+A IE S+E
Sbjct: 92 AQGVALSAKQLGLKALIVMPQNTPSI-KVDAVRGFGGEVLLHGANFDEAKAKAIELSKEK 150
Query: 187 GIYMLNSIN-PFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
+ + + P + GQ T+A E+ Q+ + D V + VG G + + K+
Sbjct: 151 NMTFIPPFDHPLVIAGQGTLAMEMLQQVADL-DYVFVQVGGGGLAAGVAILLKQFMPE-- 207
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAI---RIGNPANWEKAWRAVE 302
++IG++++ ++ L KA +K + + A + RIG ++ +R +
Sbjct: 208 ----IKIIGVESKDSACL-KAALDKGEPTDLTHIGLFADGVAVKRIG-----DETFRLCQ 257
Query: 303 ESGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVD 352
+ +V +E+ A + L EP+ A LAGL K + + ++
Sbjct: 258 QYLDDMVLVDSDEVCAAMKDLFENVRAVAEPSGALGLAGLKKYVKQNHIE 307
>gb|AAF33479.1| (AF233324) S. typhimurium threonine deaminase (ILVA) (SP:P20506);
contains similarity to Pfam families PF00291
(Pyridoxal-phosphate dependent enzyme, score=467.9,
E=8.4e-137, N=1) and PF00585 (C-terminal domain of
Threonine dehydratase, score=329.2, E=>
Length = 514
Score = 70.2 bits (169), Expect = 4e-11
Identities = 78/309 (25%), Positives = 135/309 (43%), Gaps = 24/309 (7%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRG---MTVGVSKALELGMKRVACASTG 124
TPL ++ L L + K E P SFK RG M G+++ E V AS G
Sbjct: 32 TPLQKMEKLSSRLD-NVILVKREDRQPVHSFKLRGAYAMMAGLTE--EQKAHGVITASAG 88
Query: 125 NTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASE 184
N + +A +A+ G+++ +++P + K+ +G +V+ NFD+A IE ++
Sbjct: 89 NHAQGVAFSSARLGVKSLIVMPKATADI-KVDAVRGFGGEVLLHGANFDEAKAKAIELAQ 147
Query: 185 ELGIYMLNSI-NPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEA 243
+ G + +P + GQ T+A E+ Q + D V +PVG G + + K+L
Sbjct: 148 QQGFTWVPPFDHPMVIAGQGTLALELLQQDSHL-DRVFVPVGGGGLAAGVAVLIKQLMPQ 206
Query: 244 GVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEE 303
++I ++AE ++ L A + P P A + ++ +R +E
Sbjct: 207 ------IKVIAVEAEDSACLKAALEAGH---PVDLPRVGLFAEGVAVKRIGDETFRLCQE 257
Query: 304 SGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
V + I A + L EP+ A +LAG+ K + + + R E V +G
Sbjct: 258 YLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIAQHNI-RGERLAHVLSG 316
Query: 364 -----HGLK 367
HGL+
Sbjct: 317 ANVNFHGLR 325
>gi|6322631 Pyridoxal-5'phosphate-dependent enzyme homologous to mouse glial
serine racemase; Sry1p [Saccharomyces cerevisiae]
>gi|549756|sp|P36007|YKV8_YEAST HYPOTHETICAL 34.9 KDA
PROTEIN IN COS9-JEN1 INTERGENIC REGION
>gi|539373|pir||S38061 threonine dehydratase (EC
4.2.1.16) YKL218c [similarity] - yeast (Saccharomyces
cerevisiae) >gi|473132|emb|CAA53555.1| (X75951) ORF2,
D326 [Saccharomyces cerevisiae]
>gi|486391|emb|CAA82063.1| (Z28218) ORF YKL218c
[Saccharomyces cerevisiae]
Length = 326
Score = 69.9 bits (168), Expect = 5e-11
Identities = 73/294 (24%), Positives = 132/294 (44%), Gaps = 15/294 (5%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKAL-ELGMKRVACASTGNT 126
TP+ L LG ++Y K E G+FK RG VSK E K V S+GN
Sbjct: 23 TPVLTSRMLNDRLGA-QIYFKGENFQRVGAFKFRGAMNAVSKLSDEKRSKGVIAFSSGNH 81
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEEL 186
+ ++A A + A +++P AL K+A YGA +I +D ++ + + E
Sbjct: 82 AQAIALSAKLLNVPATIVMPEDAPAL-KVAATAGYGAHIIRYNRYTEDREQIGRQLAAEH 140
Query: 187 GIYMLNSIN-PFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
G ++ + P + GQ T A E+ +++ ++ D + +P+G G +S + L
Sbjct: 141 GFALIPPYDHPDVIAGQGTSAKELLEEVGQL-DALFVPLGGGGLLSGSALAARSLSPGC- 198
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESG 305
++ G++ E + ++++ P+T+A + + E + + E+
Sbjct: 199 -----KIFGVEPEAGNDGQQSFRSG-SIVHINTPKTIADGAQTQHLG--EYTFAIIRENV 250
Query: 306 GMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVL 359
VSD+E++K LA + + VEP + AG + L EE V + +L
Sbjct: 251 DDILTVSDQELVKCMHFLAERMKVVVEPTACLGFAGAL-LKKEELVGKKVGIIL 303
>pir||T36434 threonine dehydratase (EC 4.2.1.16) SCF43A.11c [similarity] -
Streptomyces coelicolor >gi|5459225|emb|CAB48898.1|
(AL096837) putative threonine dehydratase [Streptomyces
coelicolor A3(2)]
Length = 325
Score = 69.9 bits (168), Expect = 5e-11
Identities = 70/278 (25%), Positives = 123/278 (44%), Gaps = 14/278 (5%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKR-VACASTGNT 126
TP+ R L+ ++G E++ K E G+FK RG S+ + R +A S+GN
Sbjct: 27 TPVLRSRTLDALVGA-EVHLKCENQQRVGAFKFRGAYNAASRLTPEQLARGIAAYSSGNH 85
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEEL 186
+ ++A A + G A +++P + A A YGA+++ D + V + +
Sbjct: 86 AQAVALAARELGTTAVIVMPEDAPPSKRDATAG-YGAEIVTYDRYTGDRVAVAEALAADR 144
Query: 187 GIYMLNSI-NPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
G+ ++ +P + GQ T A E+ ++ ++ D +V PVG G I+ K L+
Sbjct: 145 GLTLIPPYEHPHVIAGQGTAALELVEETGEL-DALVAPVGGGGLIAGSATAVKALHPG-- 201
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESG 305
R+IG++ E ++ R+ P T+A + P + G
Sbjct: 202 ----MRVIGVEPEAGDDTRRSLAAGRRVSVPV-PRTIADGQALPTPGELTFSLNRRLLDG 256
Query: 306 GMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLI 343
+VSD+EI A R + +EP+ A LA L+
Sbjct: 257 --IVLVSDDEIRDAMRFAFERLKTVLEPSGATPLAALL 292
>sp|P04968|THD1_ECOLI THREONINE DEHYDRATASE BIOSYNTHETIC (THREONINE DEAMINASE)
>gi|68318|pir||DWECTS threonine dehydratase (EC
4.2.1.16), biosynthetic - Escherichia coli
>gi|3891839|pdb|1TDJ| Threonine Deaminase
(Biosynthetic) From E. Coli >gi|146462|gb|AAB59054.1|
(M10313) threonine deaminase [Escherichia coli]
>gi|288533|emb|CAA28577.1| (X04890) threonine deaminase
[Escherichia coli] >gi|1790207|gb|AAC77492.1| (AE000453)
threonine deaminase (dehydratase) [Escherichia coli K12]
>gi|225743|prf||1312306B gene ilvGMEDA cluster
[Escherichia coli]
Length = 514
Score = 69.5 bits (167), Expect = 6e-11
Identities = 79/309 (25%), Positives = 134/309 (42%), Gaps = 24/309 (7%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRG---MTVGVSKALELGMKRVACASTG 124
TPL ++ L L + K E P SFK RG M G+++ E V AS G
Sbjct: 32 TPLQKMEKLSSRLD-NVILVKREDRQPVHSFKLRGAYAMMAGLTE--EQKAHGVITASAG 88
Query: 125 NTSASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASE 184
N + +A +A+ G++A +++P+ + K+ +G +V+ NFD+A IE S+
Sbjct: 89 NHAQGVAFSSARLGVKALIVMPTATADI-KVDAVRGFGGEVLLHGANFDEAKAKAIELSQ 147
Query: 185 ELGIYMLNSI-NPFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEA 243
+ G + +P + GQ T+A E+ Q + D V +PVG G + + K+L
Sbjct: 148 QQGFTWVPPFDHPMVIAGQGTLALELLQQDAHL-DRVFVPVGGGGLAAGVAVLIKQLMPQ 206
Query: 244 GVIDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETLATAIRIGNPANWEKAWRAVEE 303
++I ++AE ++ L A P P A + ++ +R +E
Sbjct: 207 ------IKVIAVEAEDSACLKAALDAGH---PVDLPRVGLFAEGVAVKRIGDETFRLCQE 257
Query: 304 SGGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
V + I A + L EP+ A +LAG+ K + + R E + +G
Sbjct: 258 YLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYIALHNI-RGERLAHILSG 316
Query: 364 -----HGLK 367
HGL+
Sbjct: 317 ANVNFHGLR 325
>sp|P53607|THD1_BURCE THREONINE DEHYDRATASE BIOSYNTHETIC (THREONINE DEAMINASE)
>gi|1113117|gb|AAA83215.1| (U40630) L-threonine
deaminase [Burkholderia cepacia]
Length = 507
Score = 69.5 bits (167), Expect = 6e-11
Identities = 73/284 (25%), Positives = 134/284 (46%), Gaps = 16/284 (5%)
Query: 85 LYAKNEGANPTGSFKDRGMTVGVSKALELGMKR-VACASTGNTSASLAAYAAKAGIEAYV 143
+Y K E P SFK RG ++ + R V AS GN + +A AA+ G++A +
Sbjct: 38 VYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHAQGVAFSAARMGVKAVI 97
Query: 144 LVP--SGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEELGIYMLNSI-NPFRLE 200
+VP + ++ + + G +VI ++ DA ++ EE G+ ++ +P+ +
Sbjct: 98 VVPVTTPQVKVDAVRAHGGPGVEVIQAGESYSDAYAHALKVQEERGLTFVHPFDDPYVIA 157
Query: 201 GQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGVIDKLPRMIGIQAEGA 260
GQ TIA EI Q Q + +P+G G + + Y V ++ ++IG+QAE +
Sbjct: 158 GQGTIAMEILRQHQGPIHAIFVPIGGGGLAAGV-----AAYVKAVRPEI-KVIGVQAEDS 211
Query: 261 SPLAKAWKE-KRKFKPEKNPETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKA 319
+A++ + KR E TA+++ E+ +R +E V + + A
Sbjct: 212 CAMAQSLQAGKRVELAEVGLFADGTAVKLVG----EETFRLCKEYLDGVVTVDTDALCAA 267
Query: 320 QRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
+ + +EP+ A ++AG KL E + +++ V VT+G
Sbjct: 268 IKDVFQDTRSVLEPSGALAVAG-AKLYAEREGIENQTLVAVTSG 310
>sp|Q60179|TRPB_METJA TRYPTOPHAN SYNTHASE BETA CHAIN >gi|2118310|pir||D64429 tryptophan
synthase (EC 4.2.1.20) beta chain - Methanococcus
jannaschii >gi|1591690|gb|AAB99040.1| (U67546)
tryptophan synthase beta subunit (trpB) [Methanococcus
jannaschii]
Length = 404
Score = 69.5 bits (167), Expect = 6e-11
Identities = 88/336 (26%), Positives = 147/336 (43%), Gaps = 34/336 (10%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSKALELGMKRV-ACASTGNT 126
TPLY L + LG K +Y K E G+ K A ++G KRV A G
Sbjct: 68 TPLYYAERLSEELGCK-VYLKREDLAHLGAHKINNALGQALLAKKMGKKRVIAETGAGQH 126
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLA--QAIIYGAKVIPIKGNFDDALRVVIEASE 184
+ AA AK G+E + + + + KL + + GAKVIP+ G V EA
Sbjct: 127 GVATAAACAKLGLECIIYMGAKDVERQKLNVFRMELMGAKVIPVFGGSQTLKDAVNEALR 186
Query: 185 E------LGIYMLNSI---NPFRL---EGQKTIAYEIYDQLQ----KVPDNVVLPVGNAG 228
+ Y+L S +P+ + E Q+ I E+ +Q+ ++PD +V VG
Sbjct: 187 DWTTNVRTTYYLLGSALGPHPYPMMVREFQRVIGKELKEQILEKEGRLPDVIVACVGGGS 246
Query: 229 N-ISAIWKGFKELYEAGVIDKLPRMIGIQAEGASPLA---------KAWKEKRKFKPEKN 278
N I A ++ + E ++ + I GAS A K + ++ +F +
Sbjct: 247 NAIGAFYEFLDDDVELYAVEAGGKGIETGMHGASLCAGEVGVLHGAKIYVKEDEFGQIE- 305
Query: 279 PETLATAIRIGNPANWEKAWRAVEESGGMFEIVSDEEILKAQRILASKEGLFVEPASAAS 338
E+ + + + P + +E V+D+E L+A ++L EG+ S+ +
Sbjct: 306 -ESYSISAGLDYPGVGPELSFLKDEGRIKAVCVTDDEALEAFQLLCRLEGILPALESSHA 364
Query: 339 LAGLIKLLNEEKVDRDESFVLVTTGHGLKDPDIVLR 374
LA +KL +K+D+D+ V+ +G G KD V +
Sbjct: 365 LAYAVKL--ADKLDKDDIMVINLSGRGDKDVQTVAK 398
>pir||E75502 threonine dehydratase (EC 4.2.1.16) DR0567 [similarity] -
Deinococcus radiodurans (strain R1)
>gi|6458263|gb|AAF10147.1|AE001915_1 (AE001915)
threonine dehydratase, biosynthetic [Deinococcus
radiodurans]
Length = 568
Score = 69.5 bits (167), Expect = 6e-11
Identities = 79/299 (26%), Positives = 139/299 (46%), Gaps = 16/299 (5%)
Query: 68 TPLYRLNNLEKILGVKELYAKNEGANPTGSFKDRGMTVGVSK-ALELGMKRVACASTGNT 126
TPL L + G + L K E P SFK RG +S+ + E + V CAS GN
Sbjct: 86 TPLSPAPRLSERSGNRVLL-KREDQQPIFSFKLRGAYNKMSQLSAEERARGVICASAGNH 144
Query: 127 SASLAAYAAKAGIEAYVLVPSGKIALGKLAQAIIYGAKVIPIKGNFDDALRVVIEASEEL 186
+ +A K GI A +++P+ + K+ GA+VI +F DA + +E
Sbjct: 145 AQGVAFAGEKLGIPAVIVMPATTPDI-KVQACRARGAEVILHGDSFSDAETFALALQQER 203
Query: 187 GIYMLNSIN-PFRLEGQKTIAYEIYDQLQKVPDNVVLPVGNAGNISAIWKGFKELYEAGV 245
G+ ++ + P L GQ TIA E+ Q+++ V +PVG G I+ + K L + GV
Sbjct: 204 GLTFVHPYDDPLVLAGQGTIALELLRQVEEDDYAVFVPVGGGGLIAGVASILKAL-KPGV 262
Query: 246 IDKLPRMIGIQAEGASPLAKAWKEKRKFKPEKNPETL-ATAIRIGNPANWEKAWRAVEES 304
R+IG++ + + + ++ + + + + + A++ ++ R V++
Sbjct: 263 -----RVIGVEPDDSDAMYQSLQAGERVRLDTVGIFVDGVAVKQVGAYTFDLTRRYVDD- 316
Query: 305 GGMFEIVSDEEILKAQRILASKEGLFVEPASAASLAGLIKLLNEEKVDRDESFVLVTTG 363
+ V+ +E+ A + + +EPA A S+AGL K + D + V +T G
Sbjct: 317 ---WVRVNTDEVCAAIKDVFDDTRAVLEPAGALSVAGLKKYAATHGL-HDRTLVALTCG 371
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.317 0.137 0.396
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 155084046
Number of Sequences: 2977
Number of extensions: 6843665
Number of successful extensions: 17778
Number of sequences better than 1.0e-10: 71
Number of HSP's better than 0.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 17554
Number of HSP's gapped (non-prelim): 75
length of query: 394
length of database: 189,106,746
effective HSP length: 57
effective length of query: 337
effective length of database: 154,992,987
effective search space: 52232636619
effective search space used: 52232636619
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 166 (69.1 bits)