BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1781 (pepQ-3) DE:X-pro aminopeptidase (pepQ-3)
(355 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||C75134 x-pro aminopeptidase (pepq-3) PAB1781 - Pyrococcus a... 718 0.0
pir||A71089 probable dipeptidase - Pyrococcus horikoshii >gi|325... 575 e-163
gb|AAK40375.1| X-pro aminopeptidase [Sulfolobus solfataricus] 273 2e-72
pir||T35868 probable dipeptidase - Streptomyces coelicolor >gi|4... 237 1e-61
pir||T46973 X-Pro dipeptidase (EC 3.4.13.9), cobalt dependent [v... 233 3e-60
pir||E75088 cobalt-dependent proline dipeptidase (pepq-2) PAB163... 230 2e-59
pir||G71056 probable X-Pro dipeptidase - Pyrococcus horikoshii >... 229 3e-59
emb|CAC10315.1| (AL442629) putative peptidase [Streptomyces coel... 220 2e-56
dbj|BAB06519.1| (AP001516) Xaa-Pro dipeptidase [Bacillus halodur... 218 7e-56
sp|P54518|YQHT_BACSU PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INTERGE... 217 1e-55
gb|AAG19202.1| (AE005016) probable peptidase; PepQ1 [Halobacteri... 217 2e-55
sp|Q10698|YK89_MYCTU PROBABLE DIPEPTIDASE RV2089C >gi|7445465|pi... 213 3e-54
gb|AAC46293.1| (AF014460) PepQ [Streptococcus mutans] 210 3e-53
emb|CAC12166.1| (AL445066) proline dipeptidase related protein [... 210 3e-53
dbj|BAB06898.1| (AP001518) prolidase (proline dipeptidase) [Baci... 209 4e-53
pir||C70433 probable X-Pro dipeptidase (EC 3.4.13.9) - Aquifex a... 209 4e-53
pir||G72425 hypothetical protein TM0042 - Thermotoga maritima (s... 207 1e-52
emb|CAB07979.1| (Z93945) prolidase-related protein [Lactobacillu... 207 1e-52
pir||G69869 Xaa-Pro dipeptidase homolog ykvY - Bacillus subtilis... 205 7e-52
emb|CAA70068.1| (Y08842) aminopeptidase P [Lactococcus lactis] 205 9e-52
sp|O84913|PEPQ_LACHE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PR... 204 1e-51
emb|CAB07978.1| (Z93944) prolidase [Lactobacillus delbrueckii] 202 6e-51
sp|Q9S6S1|PEPQ_LACDE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PR... 202 6e-51
sp|P46545|PEPQ_LACDL XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PR... 201 8e-51
gb|AAD53120.1|AF176799_2 (AF176799) PepQ [Lactobacillus pentosus] 198 9e-50
pir||D75419 proline dipeptidase - Deinococcus radiodurans (strai... 194 2e-48
pir||F65012 hypothetical protein b2385 - Escherichia coli (strai... 194 2e-48
dbj|BAA16255.1| (D90868) PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INT... 194 2e-48
pir||B72032 proline dipeptidase CP1058 [imported] - Chlamydophil... 184 1e-45
pir||C70658 probable pepQ - Mycobacterium tuberculosis (strain H... 182 6e-45
pir||H71496 probable aminopeptidase P - Chlamydia trachomatis (s... 179 5e-44
gb|AAK40693.1| Prolidase (Xaa-Pro dipeptidase) (pepQ) [Sulfolobu... 177 1e-43
pir||F82878 XAA-PRO aminopeptidase UU532 [imported] - Ureaplasma... 174 2e-42
sp|Q58216|Y806_METJA HYPOTHETICAL PEPTIDASE MJ0806 >gi|2129355|p... 172 6e-42
pir||F81657 proline dipeptidase TC0863 [imported] - Chlamydia mu... 172 6e-42
pir||E64649 probable X-Pro dipeptidase (EC 3.4.13.9) - Helicobac... 169 3e-41
pir||A71938 probable proline peptidase - Helicobacter pylori (st... 169 3e-41
pir||A72750 probable Xaa-Pro dipeptidase APE0526 - Aeropyrum per... 169 6e-41
pir||D69231 probable X-Pro dipeptidase (EC 3.4.13.9) - Methanoba... 168 1e-40
sp|P75313|AMPP_MYCPN PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMIN... 163 3e-39
emb|CAB93372.1| (AL357523) putative peptidase [Streptomyces coel... 162 7e-39
sp|P47566|AMPP_MYCGE PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMIN... 157 1e-37
pir||T39750 probable dipeptidase - fission yeast (Schizosaccharo... 154 1e-36
pir||A83084 probable metallopeptidase PA4498 [imported] - Pseudo... 145 8e-34
pir||H82833 proline dipeptidase XF0220 [imported] - Xylella fast... 133 3e-30
gi|11499616 X-pro aminopeptidase (pepQ) [Archaeoglobus fulgidus]... 128 1e-28
gb|AAG10442.1|AF279106_4 (AF279106) predicted Xaa-Pro aminopepti... 118 7e-26
sp|P15034|AMPP_ECOLI XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDAS... 115 1e-24
pdb|1A16| Aminopeptidase P From E. Coli With The Inhibitor Pro... 115 1e-24
pdb|1AZ9| Aminopeptidase P From E. Coli 115 1e-24
pdb|1JAW| Aminopeptidase P From E. Coli Low Ph Form 115 1e-24
gb|AAB96776.1| (AF041033) aminopeptidase [Shigella flexneri] 112 6e-24
pir||F82609 aminopeptidase P XF2009 [imported] - Xylella fastidi... 112 7e-24
pir||H82992 aminopeptidase P PA5224 [imported] - Pseudomonas aer... 109 4e-23
gb|AAG19595.1| (AE005049) X-pro aminopeptidase homolog; PepQ2 [H... 109 6e-23
pir||B75217 x-pro dipeptidase PAB2178 - Pyrococcus abyssi (strai... 105 7e-22
sp|P44881|AMPP_HAEIN XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDAS... 104 2e-21
pir||S76440 hypothetical protein - Synechocystis sp. (strain PCC... 103 3e-21
gi|11559925 hypothetical protein LOC63929 [Homo sapiens] >gi|918... 103 3e-21
pir||D71204 hypothetical protein PH1902 - Pyrococcus horikoshii ... 102 6e-21
gb|AAF45368.1| (AE002611) CG9581 gene product [Drosophila melano... 102 6e-21
gb|AAD18095.1| (AC006416) Similar to gi|1573829 HI0816 aminopept... 101 1e-20
sp|Q05813|AMP1_STRLI XAA-PRO AMINOPEPTIDASE I (X-PRO AMINOPEPTID... 99 9e-20
dbj|BAB05458.1| (AP001513) Xaa-Pro dipeptidase [Bacillus halodur... 91 2e-17
sp|Q60394|AMP2_STRLI XAA-PRO AMINOPEPTIDASE II (X-PRO AMINOPEPTI... 89 8e-17
gi|10955071 agcA [Agrobacterium tumefaciens] >gi|2329863|emb|CAA... 88 1e-16
pir||T32753 hypothetical protein W03G9.4 - Caenorhabditis elegan... 88 1e-16
emb|CAB62984.1| (AL035450) dJ1057D18.1 (novel protein similar to... 87 2e-16
pir||D81414 probable aminopeptidase Cj0653c [imported] - Campylo... 87 3e-16
sp|P38487|CREA_BACSP CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|... 86 7e-16
sp|O51132|AMPM_BORBU METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 85 1e-15
pir||S69353 aminopeptidase P - pig >gi|994862|gb|AAB34314.1| ami... 84 2e-15
pir||T47008 hypothetical protein [imported] - Yersinia pestis >g... 84 2e-15
sp|P27875|AGS_AGRRH AGROPINE SYNTHESIS CYCLASE >gi|77884|pir||JQ... 84 3e-15
sp|Q10439|YDE5_SCHPO PROBABLE 55.1 KDA PEPTIDASE C12B10.05 >gi|7... 84 3e-15
emb|CAA19220.1| (AL023653) dJ753P9.1 (Aminopeptidase P (EC 3.4.1... 83 3e-15
gi|10880126 X-prolyl aminopeptidase 2, membrane-bound; aminoacyl... 83 3e-15
gi|6320922 Yer078cp [Saccharomyces cerevisiae] >gi|731481|sp|P40... 83 5e-15
gi|10955029 ags [Agrobacterium tumefaciens] >gi|8572686|gb|AAF77... 83 5e-15
gi|11420265 X-prolyl aminopeptidase 2, membrane-bound [Homo sapi... 83 5e-15
pir||S72440 X-Pro aminopeptidase (EC 3.4.11.9) precursor - pig >... 82 8e-15
gi|6321118 Yfr006wp [Saccharomyces cerevisiae] >gi|1175977|sp|P4... 82 1e-14
pir||F72247 methionine aminopeptidase - Thermotoga maritima (str... 82 1e-14
pir||T44250 creatinase (EC 3.5.3.3) [validated] - Arthrobacter s... 81 2e-14
gb|AAF53589.1| (AE003653) ApepP gene product [Drosophila melanog... 81 2e-14
sp|Q9Z9J4|AMPM_BACHD METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 80 3e-14
pir||E71651 hypothetical protein RP482 - Rickettsia prowazekii >... 80 4e-14
pir||E81084 aminopeptidase, probable NMB1428 [imported] - Neisse... 79 9e-14
pir||D81858 probable aminopeptidase NMA1640 [imported] - Neisser... 79 9e-14
gb|AAF75795.1|AF272981_1 (AF272981) cytosolic aminopeptidase P [... 79 9e-14
gi|5730118 X-prolyl aminopeptidase (aminopeptidase P)-like; pepP... 78 1e-13
emb|CAA10526.1| (AJ131920) aminopeptidase P [Drosophila melanoga... 78 1e-13
gb|AAB95331.1| (AF038591) cytoplasmic aminopeptidase P [Rattus n... 78 2e-13
pir||C75410 methionine aminopeptidase - Deinococcus radiodurans ... 78 2e-13
sp|P53581|AMP3_SYNY3 PUTATIVE METHIONINE AMINOPEPTIDASE C (MAP) ... 76 6e-13
sp|P19213|CREA_FLASU CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|... 76 8e-13
pir||A75514 peptidase-related protein - Deinococcus radiodurans ... 76 8e-13
sp|O83814|AMPM_TREPA METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 75 1e-12
pir||C82367 aminopeptidase P VC0067 [imported] - Vibrio cholerae... 75 1e-12
pdb|1CHM|B Chain B, Creatine Amidinohydrolase (E.C.3.5.3.3) 74 2e-12
sp|P38488|CREA_PSEPU CREATINASE (CREATINE AMIDINOHYDROLASE) 74 2e-12
pdb|1CHM|A Chain A, Creatine Amidinohydrolase (E.C.3.5.3.3) 74 2e-12
gi|11499425 methionyl aminopeptidase (map) [Archaeoglobus fulgid... 74 3e-12
pir||A81262 methionyl aminopeptidase (EC 3.4.11.18) Cj1651c [imp... 74 3e-12
sp|P07906|AMPM_ECOLI METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 73 4e-12
gb|AAD37463.1| (AF072304) creatinase [Pseudomonas putida] 73 4e-12
pdb|2MAT|A Chain A, E.Coli Methionine Aminopeptidase At 1.9 Angs... 73 4e-12
pdb|1C22|A Chain A, E. Coli Methionine Aminopeptidase: Trifluoro... 73 4e-12
pdb|3MAT|A Chain A, E.Coli Methionine Aminopeptidase Transition-... 73 4e-12
pdb|4MAT|A Chain A, E.Coli Methionine Aminopeptidase His79ala Mu... 73 4e-12
sp|O58362|AMPM_PYRHO METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 73 5e-12
gb|AAD52565.4|AF170566_1 (AF170566) creatinase [Pseudomonas putida] 73 5e-12
sp|P19994|AMPM_BACSU METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE ... 73 7e-12
pir||E82845 methionine aminopeptidase XF0111 [imported] - Xylell... 72 9e-12
gb|AAD27841.1|AF124600_4 (AF124600) putative cytoplasmic peptida... 72 1e-11
gi|6322999 Yll029wp [Saccharomyces cerevisiae] >gi|2131729|pir||... 71 1e-11
emb|CAB16823.1| (Z99708) aminopeptidase-like protein [Arabidopsi... 71 2e-11
pir||C75054 methionyl aminopeptidase (EC 3.4.11.18) map PAB1434 ... 71 3e-11
dbj|BAA95761.1| (AB028607) methionine aminopeptidase-like protei... 70 3e-11
dbj|BAB03321.1| (AB035448) methionin aminopeptidase [Staphylococ... 70 4e-11
emb|CAB16790.1| (Z99707) methionyl aminopeptidase-like protein [... 69 6e-11
gb|AAG33977.1|AF250963_1 (AF250963) methionine aminopeptidase-li... 69 6e-11
sp|P55666|Y4TL_RHISN HYPOTHETICAL HYDROLASE/PEPTIDASE Y4TL >gi|2... 69 8e-11
gb|AAC16431.1| (AF063007) similar to the peptidase family M; Pfa... 69 8e-11
gb|AAF47587.1| (AE003473) dre4 gene product [Drosophila melanoga... 69 1e-10
pir||D83189 methionine aminopeptidase PA3657 [imported] - Pseudo... 69 1e-10
>pir||C75134 x-pro aminopeptidase (pepq-3) PAB1781 - Pyrococcus abyssi (strain
Orsay) >gi|5458299|emb|CAB49788.1| (AJ248285) X-pro
aminopeptidase (pepQ-3) [Pyrococcus abyssi]
Length = 355
Score = 718 bits (1832), Expect = 0.0
Identities = 355/355 (100%), Positives = 355/355 (100%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLY 60
MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLY
Sbjct: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLY 60
Query: 61 SNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHP 120
SNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHP
Sbjct: 61 SNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHP 120
Query: 121 LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSD 180
LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSD
Sbjct: 121 LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSD 180
Query: 181 GVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
GVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL
Sbjct: 181 GVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP
Sbjct: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
Query: 301 YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELITV 355
YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELITV
Sbjct: 301 YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELITV 355
>pir||A71089 probable dipeptidase - Pyrococcus horikoshii
>gi|3257388|dbj|BAA30071.1| (AP000004) 356aa long
hypothetical dipeptidase [Pyrococcus horikoshii]
Length = 356
Score = 575 bits (1466), Expect = e-163
Identities = 270/354 (76%), Positives = 316/354 (88%), Gaps = 1/354 (0%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLY 60
MR+++F+ LL E FDGA ISPG+NLYYLTGL+LHEVGER IL VSA+G+Y+ LAPSLY
Sbjct: 1 MRLEKFIHLLGERGFDGALISPGTNLYYLTGLRLHEVGERLAILAVSAEGDYRFLAPSLY 60
Query: 61 SNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHP 120
NV+ NFP TFW DGENPYAKL IL EL + +GR L+EDTMRADWLIGI+KLG F F P
Sbjct: 61 ENVVNNFPATFWHDGENPYAKLREILEELGISKGRILIEDTMRADWLIGIMKLGKFTFQP 120
Query: 121 LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSD 180
LSSLI+ +RM KD+EE++ M+HA+RIADKVFEEIL+WD++GM E+ELALKIE+ IRELSD
Sbjct: 121 LSSLIKELRMIKDKEEVKMMEHASRIADKVFEEILTWDLIGMKERELALKIELLIRELSD 180
Query: 181 GVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
G++F PIVASGEN+ANPHHEPGERKIRKGDI+ILDYGARW+GYCSDITRTI +G DE+L
Sbjct: 181 GIAFEPIVASGENAANPHHEPGERKIRKGDIIILDYGARWKGYCSDITRTIGLGELDERL 240
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
+++YE+VK+AQE A++AVREGIKAK+VD AREVIS+AGYGEYF HRTGHGLGLDVHEEP
Sbjct: 241 VKIYEVVKDAQESAFKAVREGIKAKDVDSRAREVISKAGYGEYFIHRTGHGLGLDVHEEP 300
Query: 301 YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV-EGKGKRLTKAGRELI 353
YIGPDGEV L+NGMTFTIEPGIY+PGLGGVRIEDD+VV EGKG+RLTKA RELI
Sbjct: 301 YIGPDGEVILKNGMTFTIEPGIYVPGLGGVRIEDDIVVDEGKGRRLTKAERELI 354
>gb|AAK40375.1| X-pro aminopeptidase [Sulfolobus solfataricus]
Length = 351
Score = 273 bits (691), Expect = 2e-72
Identities = 152/361 (42%), Positives = 223/361 (61%), Gaps = 19/361 (5%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
RI R K L N D SN+YYL G ++ ERP +L ++ D +Y LL P LY
Sbjct: 3 RIQRVQKELERANADYLITGTTSNMYYLIGFSEEQM-ERPLLLFITRD-DYFLLVPKLYE 60
Query: 62 NVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHP- 120
+ FP+ +RDGE+PY+KL+ LK L++DT + + I IL F P
Sbjct: 61 EQLKQFPLIVYRDGEDPYSKLN-----LK-ENSNVLIDDTTFSLFTIEILN----RFKPG 110
Query: 121 ----LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIR 176
S ++ +R KD EE+E M+ + A+++ E +S M+E ++ K++ +
Sbjct: 111 RIGRASRILGKLRQVKDDEELEKMEKGVKKAEQLILEFVSNIKENMTECQIERKLKSFLI 170
Query: 177 ELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRP 236
E + +SF PIV SG NS+ PH ++K+++G+ +++DYG + GY +D TR ++G+P
Sbjct: 171 EEAGNISFDPIVTSGPNSSMPHLRCSDKKVKRGEAIVIDYGIKHDGYSTDTTRVFSLGKP 230
Query: 237 DEKLI-EVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLD 295
++ LI E+ EIVK A E+A + VREG++AKE+D AREVI+ GYG+YF HRTGHG+G+D
Sbjct: 231 NDPLILEIVEIVKTANEEAEKHVREGMRAKEIDYFAREVITNKGYGDYFIHRTGHGIGID 290
Query: 296 VHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV-EGKGKRLTKAGRELIT 354
VHE+PYI PD + +E M FTIEPGIY+PG G+RIED+VVV +G GK L +EL
Sbjct: 291 VHEDPYISPDNDDVIEQNMVFTIEPGIYLPGKFGIRIEDEVVVKKGYGKTLNMLQKELYI 350
Query: 355 V 355
+
Sbjct: 351 I 351
>pir||T35868 probable dipeptidase - Streptomyces coelicolor
>gi|4691402|emb|CAB41569.1| (AL049727) putative
dipeptidase [Streptomyces coelicolor A3(2)]
Length = 376
Score = 237 bits (599), Expect = 1e-61
Identities = 139/362 (38%), Positives = 202/362 (55%), Gaps = 12/362 (3%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
R++R + + G ++PG +L +LTG ER T+LV++ D + L+ P+L +
Sbjct: 18 RMERAARAAADAGLAGLLVAPGPDLVWLTGYAPTADTERLTLLVLAPDRDPVLVVPTLEA 77
Query: 62 NVITN------FPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILK-LG 114
+ W DG++PYA + +L GRF + D A L+ + + L
Sbjct: 78 PDAAKAAGAPALTLRDWTDGKDPYAATAALLDG----SGRFGISDNAWAMHLLALQRTLP 133
Query: 115 NFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVR 174
+ + L+ + ++R KD E+E + A AD FEEI G E E+A +
Sbjct: 134 DTSYASLTEALPMLRAVKDAAELELLAAAGAAADAAFEEIRRVRFGGRRESEVAADLADL 193
Query: 175 IRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVG 234
+R IVASG N ANPHHE G+R I GD+++LD+G GY SD +RT+ VG
Sbjct: 194 LRRFGHSQVDFTIVASGPNGANPHHEVGDRVIEDGDMIVLDFGGLKDGYGSDTSRTVHVG 253
Query: 235 RPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGL 294
P ++ V+++V+EAQE + AVR G ++VD+ AR VI+ AGYGEYF HRTGHG+G+
Sbjct: 254 APTDEERRVHDLVREAQEAGFCAVRPGAACQDVDRAARAVIAGAGYGEYFIHRTGHGIGV 313
Query: 295 DVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDV-VVEGKGKRLTKAGRELI 353
HE PY+ E L GM F++EPG+Y+PG GVRIED V V E G+RL RE++
Sbjct: 314 TTHEPPYMIEGEEQPLVPGMCFSVEPGVYLPGRFGVRIEDIVTVTEDGGRRLNDTTREMV 373
Query: 354 TV 355
V
Sbjct: 374 LV 375
>pir||T46973 X-Pro dipeptidase (EC 3.4.13.9), cobalt dependent [validated] -
Pyrococcus furiosus (fragment)
>gi|3372642|gb|AAC61259.1| (AF060010) proline
dipeptidase [Pyrococcus furiosus]
Length = 348
Score = 233 bits (587), Expect = 3e-60
Identities = 142/360 (39%), Positives = 206/360 (56%), Gaps = 23/360 (6%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
R+++ VK ++E + D FI+ N+YY +G G ++V D E L P L
Sbjct: 4 RLEKLVKFMDENSIDRVFIAKPVNVYYFSGTSPLGGG----YIIVDGD-EATLYVPELEY 58
Query: 62 NVI---TNFPVTFWRDGENPYA--KLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNF 116
+ + PV ++ + Y K + LG +E T+ + + N
Sbjct: 59 EMAKEESKLPVVKFKKFDEIYEILKNTETLG----------IEGTLSYSMVENFKEKSNV 108
Query: 117 -EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI 175
EF + +I+ +R+ K +EEIE ++ A IADK + G E+E+A K+E +
Sbjct: 109 KEFKKIDDVIKDLRIIKTKEEIEIIEKACEIADKAVMAAIEEITEGKREREVAAKVEYLM 168
Query: 176 R-ELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVG 234
+ ++ +F I+ASG SA PH +++I +GD+V++D GA + Y SDITRTI VG
Sbjct: 169 KMNGAEKPAFDTIIASGHRSALPHGVASDKRIERGDLVVIDLGALYNHYNSDITRTIVVG 228
Query: 235 RPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGL 294
P+EK E+YEIV EAQ++A A + G+ AKE+D +ARE+I E GYG+YF H GHG+GL
Sbjct: 229 SPNEKQREIYEIVLEAQKRAVEAAKPGMTAKELDSIAREIIKEYGYGDYFIHSLGHGVGL 288
Query: 295 DVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV-EGKGKRLTKAGRELI 353
++HE P I E L+ GM TIEPGIYIP LGGVRIED V++ E KRLTK REL+
Sbjct: 289 EIHEWPRISQYDETVLKEGMVITIEPGIYIPKLGGVRIEDTVLITENGAKRLTKTERELL 348
>pir||E75088 cobalt-dependent proline dipeptidase (pepq-2) PAB1637 - Pyrococcus
abyssi (strain Orsay) >gi|5458522|emb|CAB50010.1|
(AJ248286) cobalt-dependent proline dipeptidase
(pepQ-2) [Pyrococcus abyssi]
Length = 351
Score = 230 bits (581), Expect = 2e-59
Identities = 138/357 (38%), Positives = 202/357 (55%), Gaps = 17/357 (4%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
+I R ++ +NE + D I+ N+YYL+G G ++V+ DG L P L
Sbjct: 7 KIKRIIEFMNENSIDAVLITKNPNIYYLSGASPLAGG----YILVNNDGA-TLYVPELEY 61
Query: 62 NVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFL--VEDTMRADWLIGILKLGNF-EF 118
+ + + P K K++ G + +E ++ ++ + + G EF
Sbjct: 62 EMAKE-------ESKIPVEKFKRRDDFYKVFEGVKVLGIEGSLSYSFVEDLKEKGKISEF 114
Query: 119 HPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIR-E 177
+ +I+ MR+ K EEI+ ++ A IADK + G E+E+A K+E ++
Sbjct: 115 KKVDDVIKEMRIVKSDEEIKIIEKACEIADKAVMAAIEEVTEGKKEREIAAKVEYLMKMN 174
Query: 178 LSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPD 237
++ +F I+ASG SA PH +++I KGD+V++D GA + Y SDITRT+ VG P+
Sbjct: 175 GAEKPAFDTIIASGYRSALPHGVASDKRIEKGDLVVIDLGALYNHYNSDITRTVVVGSPN 234
Query: 238 EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVH 297
EK E+YEIV EAQ+KA A R GI KE+D +AR +I E GYG+YF H GHG+GL++H
Sbjct: 235 EKQREIYEIVLEAQKKAVEAARPGITTKELDSIARNIIKEYGYGDYFIHSLGHGVGLEIH 294
Query: 298 EEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAGRELI 353
E P + E L+ GM TIEPGIYIP GGVRIED +V+ G +RLTK RELI
Sbjct: 295 EWPGVSQYDETVLKEGMVITIEPGIYIPKFGGVRIEDTIVITKTGARRLTKTERELI 351
>pir||G71056 probable X-Pro dipeptidase - Pyrococcus horikoshii
>gi|3257566|dbj|BAA30249.1| (AP000005) 351aa long
hypothetical X-Pro dipeptidase [Pyrococcus horikoshii]
Length = 351
Score = 229 bits (579), Expect = 3e-59
Identities = 138/363 (38%), Positives = 207/363 (57%), Gaps = 29/363 (7%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLK------LHEVGERPTILVVSADGEYKLL 55
++ + ++ +++ + D I+ N+YY++G + GE T+ V EY++
Sbjct: 7 KVKKIIEFMDKNSIDAVLIAKNPNVYYISGASPLAGGYILITGESATLYVPEL--EYEMA 64
Query: 56 APSLYSNVITNFPVTFWRDGENPYAKLSTI--LGELKLYRGRFLVEDTMRADWLIGILKL 113
+N PV ++ + Y L I LG +E ++ ++ + K
Sbjct: 65 KEE------SNIPVEKFKKMDEFYKALEGIKSLG----------IESSLPYGFIEELKKK 108
Query: 114 GNF-EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIE 172
N EF + +IR MR+ K +EI+ ++ A IADK + G E+E+A K+E
Sbjct: 109 ANIKEFKKVDDVIRDMRIIKSEKEIKIIEKACEIADKAVMAAIEEITEGKKEREVAAKVE 168
Query: 173 VRIR-ELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTI 231
++ ++ +F I+ASG SA PH +++I +GD+V++D GA ++ Y SDITRTI
Sbjct: 169 YLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIERGDLVVIDLGALYQHYNSDITRTI 228
Query: 232 AVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHG 291
VG P+EK E+YEIV EAQ+KA + + GI AKE+D +AR +I+E GYGEYF H GHG
Sbjct: 229 VVGSPNEKQKEIYEIVLEAQKKAVESAKPGITAKELDSIARNIIAEYGYGEYFNHSLGHG 288
Query: 292 LGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAGR 350
+GL+VHE P + E L GM TIEPGIYIP +GGVRIED +++ G KRLTK R
Sbjct: 289 VGLEVHEWPRVSQYDETVLREGMVITIEPGIYIPKIGGVRIEDTILITKNGSKRLTKTER 348
Query: 351 ELI 353
ELI
Sbjct: 349 ELI 351
>emb|CAC10315.1| (AL442629) putative peptidase [Streptomyces coelicolor]
Length = 375
Score = 220 bits (554), Expect = 2e-56
Identities = 135/365 (36%), Positives = 197/365 (52%), Gaps = 18/365 (4%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
R+DR + G ++PG +L +L G + ER T+LV++A + +LL P+L
Sbjct: 17 RMDRTAYQAAALGLAGVLVTPGPDLVWLCGYRPTAPIERLTLLVLTATSQPRLLVPALDR 76
Query: 62 NVITNFP------VTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGIL---- 111
P V+ W +G++ YA + +L GR+ V D A W + +L
Sbjct: 77 PTAEASPGAGAVRVSDWWEGQDAYAAAAGLLRP----HGRYAVSD---ATWALHLLCLQA 129
Query: 112 KLGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKI 171
L + PLS ++ + R KD +E+ + AA AD +EE+L G SE+ELA +
Sbjct: 130 SLPLATYQPLSVVLPMRRAVKDEQEMARLTAAAAAADTAYEEVLGLRFGGRSERELAADL 189
Query: 172 EVRIRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTI 231
+R +V +G ++A+PHH PG+R I GD+V+LD+G GY DI RT+
Sbjct: 190 AGLLRAHGHSRVDFTVVGAGPHAADPHHRPGDRVIGDGDMVVLDFGGLKDGYGFDIARTV 249
Query: 232 AVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHG 291
VG P ++ V+E V+ AQ A+ AVR G+ +EVD+ AR VI EAG+ + RTGHG
Sbjct: 250 HVGAPTDEERRVHETVRAAQRAAFGAVRPGVSCQEVDRAARAVIEEAGHAGHGARRTGHG 309
Query: 292 LGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVV-VEGKGKRLTKAGR 350
+G+ HE PY+ E LE GM F++EPGI++P GVRIED V E G+RL
Sbjct: 310 VGVTTHEPPYLVEGEEQPLEPGMCFSLEPGIHLPDRFGVRIEDVVTCTEDGGRRLNTTSH 369
Query: 351 ELITV 355
EL V
Sbjct: 370 ELAIV 374
>dbj|BAB06519.1| (AP001516) Xaa-Pro dipeptidase [Bacillus halodurans]
Length = 355
Score = 218 bits (550), Expect = 7e-56
Identities = 114/246 (46%), Positives = 163/246 (65%), Gaps = 2/246 (0%)
Query: 112 KLGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKI 171
KL + E P++ L+ +R+ KD E++ M+ AA IAD F I S+ G++E+E+A ++
Sbjct: 108 KLVDSELVPVAGLVENIRLIKDETELQIMQEAANIADAAFAHITSYIRAGVTEREVANEL 167
Query: 172 EVRIREL-SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRT 230
E +R+ ++ SF IVASG SA PH ++ I KG++V LD+GA ++GYCSDITRT
Sbjct: 168 EFFMRKQGAESSSFDIIVASGYRSALPHGVASDKVIEKGELVTLDFGAYYKGYCSDITRT 227
Query: 231 IAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGH 290
+AVG +++L ++Y+ V EAQ K ++ GI KE D + R+ I+ GYGEYF H TGH
Sbjct: 228 VAVGDINDELRKIYDTVLEAQLKGMEGIKPGITGKEADALTRDHITAKGYGEYFGHSTGH 287
Query: 291 GLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKR-LTKAG 349
GLGL+VHE P + + L+ GM T+EPGIYI G+GG RIEDD V+ G R LTK+
Sbjct: 288 GLGLEVHEGPGLSMKSKAVLKPGMVVTVEPGIYISGVGGTRIEDDTVITESGNRSLTKSP 347
Query: 350 RELITV 355
+EL+ V
Sbjct: 348 KELLFV 353
>sp|P54518|YQHT_BACSU PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INTERGENIC REGION
>gi|7430115|pir||C69960 Xaa-Pro dipeptidase homolog yqhT
- Bacillus subtilis >gi|1303901|dbj|BAA12557.1| (D84432)
YqhT [Bacillus subtilis] >gi|2634880|emb|CAB14377.1|
(Z99116) similar to Xaa-Pro dipeptidase [Bacillus
subtilis]
Length = 353
Score = 217 bits (548), Expect = 1e-55
Identities = 134/374 (35%), Positives = 203/374 (53%), Gaps = 44/374 (11%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLY 60
M++++ L ++ DG I+ +N+ Y+TG + V+S D
Sbjct: 1 MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFT-----GSAGLAVISGDK---------- 45
Query: 61 SNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLG------ 114
+ IT+F T AK+ + G + G L++ T GI +LG
Sbjct: 46 AAFITDFRYT-------EQAKVQ-VKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSM 97
Query: 115 -------------NFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILG 161
+ E P++ + +R+ K EEI+ ++ AA+IAD F IL++ G
Sbjct: 98 TYGTYASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPG 157
Query: 162 MSEKELALKIEVRIREL-SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARW 220
+SE +A ++E +R +D SF IVASG S+ PH ++ I GD+V LD+GA +
Sbjct: 158 ISEIAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYY 217
Query: 221 RGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGY 280
+GYCSDITRT+AVG+P ++L E+Y++V +AQ ++ G+ KE D + R+ I+ GY
Sbjct: 218 KGYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKGY 277
Query: 281 GEYFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEG 340
G+YF H TGHGLG++VHE P + LE GM T+EPGIYIP GGVRIEDD+V+
Sbjct: 278 GDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIVITE 337
Query: 341 KGKR-LTKAGRELI 353
G R +T + +ELI
Sbjct: 338 NGNRTITHSPKELI 351
>gb|AAG19202.1| (AE005016) probable peptidase; PepQ1 [Halobacterium sp. NRC-1]
Length = 369
Score = 217 bits (546), Expect = 2e-55
Identities = 136/341 (39%), Positives = 191/341 (55%), Gaps = 12/341 (3%)
Query: 8 KLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYSNVITNF 67
+ L + GA + P NLYYL+G ER +LVV ADGE +AP+LY +
Sbjct: 13 RTLRDAGAAGAVLFPSPNLYYLSGFD-ETPSERLLVLVVPADGEPAFVAPALYETQLAAE 71
Query: 68 P----VTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILK--LGNFEFHPL 121
+ + D ++P A + + + L GR LV+ TM A + +L+ L + +
Sbjct: 72 TWVDDIRTYTDSQDPSAVVRAVAADRGLTDGRLLVDPTMWAQFT-QLLRDTLPDATWGLA 130
Query: 122 SSLIRLMRMRKDREEIENMKHAARIADKVFEEI--LSWDILGMSEKELALKIEVRIRELS 179
+++ +R+RKD E++ ++ A AD ++ L D +GM+E ELA I R+
Sbjct: 131 DAVLGSLRVRKDDAELDALRRAGGAADAAMADVRGLGADAIGMTEHELADFIADRLAAHG 190
Query: 180 D-GVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIA-VGRPD 237
GVSF I SG N A PHH R+I++GD V+ D+G Y SD TRT+ G P
Sbjct: 191 GTGVSFDVIAGSGPNGAKPHHTHDAREIQRGDPVVCDFGTVVDRYPSDQTRTVVFAGDPP 250
Query: 238 EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVH 297
V+E+V++A A AV G+ A VD AR VI++AGYG+ F HRTGHG+GLDVH
Sbjct: 251 AAFRTVHEVVRDAHRAAVDAVEPGVSAGAVDAAARRVIADAGYGDAFVHRTGHGVGLDVH 310
Query: 298 EEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV 338
E P+I D + L+ GM F+IEPG+Y PG GVRIED VVV
Sbjct: 311 EAPFIVADSDRKLDVGMVFSIEPGVYRPGEFGVRIEDLVVV 351
>sp|Q10698|YK89_MYCTU PROBABLE DIPEPTIDASE RV2089C >gi|7445465|pir||D70767 probable pepQ
- Mycobacterium tuberculosis (strain H37RV)
>gi|1370256|emb|CAA98201.1| (Z73966) pepE [Mycobacterium
tuberculosis]
Length = 375
Score = 213 bits (536), Expect = 3e-54
Identities = 132/349 (37%), Positives = 195/349 (55%), Gaps = 15/349 (4%)
Query: 17 GAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYSNVITN-------FPV 69
G I+PG +L YL G + E ER T LV+ A G ++ P L + V
Sbjct: 29 GLVITPGYDLCYLIGSRA-ETFERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRV 87
Query: 70 TFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHPLSSLIRLMR 129
W DG++PY +S +LG + V D+M A ++ + + ++R +R
Sbjct: 88 CDWVDGDDPYGLVSAVLGGAPVATA---VTDSMPALHMLPLADALGVLPVLATDVLRRLR 144
Query: 130 MRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKI-EVRIRELSDGVSFSPIV 188
M K+ EI+ ++ A D+V + + + G +E ++A I E + E V+F IV
Sbjct: 145 MVKEETEIDALRKAGAAIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGHSEVAFV-IV 203
Query: 189 ASGENSANPHHEPGERKIRKGDIVILDYGARWR-GYCSDITRTIAVGRPDEKLIEVYEIV 247
SG + A+PHH +R++R+GDIV++D G + GY SD TRT ++G PD + + Y ++
Sbjct: 204 GSGPHGADPHHGYSDRELREGDIVVVDIGGTYGPGYHSDSTRTYSIGEPDSDVAQSYSML 263
Query: 248 KEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGPDGE 307
+ AQ A+ A+R G+ A++VD AR+V++EAG EYF HRTGHG+GL VHEEPYI +
Sbjct: 264 QRAQRAAFEAIRPGVTAEQVDAAARDVLAEAGLAEYFVHRTGHGIGLCVHEEPYIVAGND 323
Query: 308 VTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGK-RLTKAGRELITV 355
+ L GM F+IEPGIY PG G RIED V+V G + ELI V
Sbjct: 324 LVLVPGMAFSIEPGIYFPGRWGARIEDIVIVTEDGAVSVNNCPHELIVV 372
>gb|AAC46293.1| (AF014460) PepQ [Streptococcus mutans]
Length = 359
Score = 210 bits (528), Expect = 3e-53
Identities = 129/357 (36%), Positives = 196/357 (54%), Gaps = 7/357 (1%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAP---S 58
++ + V+ L + + A +S ++ YLTG + ER L + AD E L P +
Sbjct: 3 KLAQIVQKLKKQGIEAAVLSDPVSINYLTGF-YSDPHERLMFLFLFADQETLLFLPELDA 61
Query: 59 LYSNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEF 118
L + I + VT + D ENP K+ T+L + Y L D + G+ + + +F
Sbjct: 62 LRAKSILDISVTGYLDFENPLEKIKTLLPKTN-YSKIALEFDNLNVTKFKGLETIFSGQF 120
Query: 119 HPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL 178
L+ LI MR+ K +EI+ + A +ADK + L +E ++ +IE +++L
Sbjct: 121 TNLTPLINRMRLIKSADEIQKLLIAGELADKAVQIGFDSISLNATETDIIAQIEFEMKKL 180
Query: 179 S-DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPD 237
D +SF +V +G N+ANPH P KI +++ D G GY SD+TRT+AVG+PD
Sbjct: 181 GVDKMSFETMVLTGSNAANPHGLPASHKIENNHLLLFDLGVESTGYVSDMTRTVAVGQPD 240
Query: 238 EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVH 297
+ ++Y I EAQ A ++ G+ A +VD AR VI +AGYG+YF HR GHG+G+ +H
Sbjct: 241 QFKKDIYNICLEAQLTALDFIKPGVSAAQVDAAARSVIEKAGYGDYFNHRLGHGIGMGLH 300
Query: 298 EEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAGRELI 353
E P I ++ LE GM F++EPGIYIP GVRIED V G + T+ +EL+
Sbjct: 301 EFPSIMAGNDMLLEEGMCFSVEPGIYIPEKVGVRIEDCGHVTKNGFEVFTQTPKELL 357
>emb|CAC12166.1| (AL445066) proline dipeptidase related protein [Thermoplasma
acidophilum]
Length = 360
Score = 210 bits (528), Expect = 3e-53
Identities = 109/239 (45%), Positives = 151/239 (62%), Gaps = 8/239 (3%)
Query: 117 EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIE-VRI 175
EF +S+ I R K EE++ ++ AA+I +V ++L GM+E E+A KI + +
Sbjct: 118 EFLDVSASILEARKIKQAEELKKIREAAKIGSEVLPDVLDSLKEGMTEYEVASKIVYLMM 177
Query: 176 RELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGR 235
+ + G SF IVA G+N+A PH+ PG+ K+++GD V++DYGAR+ GYCSDITRT+ G+
Sbjct: 178 KNGASGPSFDTIVAFGQNAAMPHYSPGQAKLKRGDFVLMDYGARYMGYCSDITRTVVFGK 237
Query: 236 PDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLD 295
E+ E+Y VKEAQ +A+REG K+VD AR +I Y F H GHG+GL+
Sbjct: 238 ATEEQKEMYNTVKEAQAAGMKAIREGANGKDVDAAARNIIDSTKYKGRFIHSLGHGVGLE 297
Query: 296 VHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELIT 354
VH+ P + P + L+ M T+EPGIY+PG GGVRIEDDVVV TK G E IT
Sbjct: 298 VHDHPALSPTMDFPLKANMVVTVEPGIYVPGYGGVRIEDDVVV-------TKEGYEKIT 349
>dbj|BAB06898.1| (AP001518) prolidase (proline dipeptidase) [Bacillus halodurans]
Length = 364
Score = 209 bits (527), Expect = 4e-53
Identities = 127/352 (36%), Positives = 197/352 (55%), Gaps = 16/352 (4%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
RI R ++ L + + AFI ++++YLTG + ER L++ + E L+ P++ +
Sbjct: 3 RIKRVIEWLKDNDHSMAFIQDKTSIFYLTGFYC-DPHERLVSLLLFPEAEPCLICPNMET 61
Query: 62 NVITNF----PVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFE 117
+++ + + D E+P+ + + + +VE + L+ +
Sbjct: 62 SLVKEAGWTGEILGYSDIEDPWLLVRQAVEKRNAVLTSCIVEAPRLTYARVQALQ----D 117
Query: 118 FHPLSSLIR----LMRMRKDR--EEIENMKHAARIADKVFEEILSWDILGMSEKELALKI 171
P LI LM +RK + +E+ +K AA +AD E + G SE E+ I
Sbjct: 118 AFPAIKLIDGEPFLMELRKQKSAKELTTLKEAAALADYGVEVGVQAIQEGRSEIEILALI 177
Query: 172 EVRIRELS-DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRT 230
E ++ +SF +V SG+ SANPH PG+R I+KGD V+ D G GYCSDITRT
Sbjct: 178 EYELKRKGVRDMSFGTLVLSGDQSANPHGNPGQRTIKKGDFVLFDLGVVLDGYCSDITRT 237
Query: 231 IAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGH 290
+A ++ ++YE V++AQ+ A A R G++ + +D++AR +I+EAGYG+YF HR GH
Sbjct: 238 VAFHHVTDQQQDIYETVRKAQQAALDACRPGVEIRTLDQIARTIITEAGYGDYFPHRIGH 297
Query: 291 GLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG 342
GLG++VHE P + L+ GM FTIEPGIY+P +GGVRIEDDVV+ G
Sbjct: 298 GLGMEVHELPSLNETNTDRLQKGMVFTIEPGIYLPSIGGVRIEDDVVITEDG 349
>pir||C70433 probable X-Pro dipeptidase (EC 3.4.13.9) - Aquifex aeolicus
>gi|2983896|gb|AAC07447.1| (AE000744) xaa-pro
dipeptidase [Aquifex aeolicus]
Length = 354
Score = 209 bits (527), Expect = 4e-53
Identities = 130/364 (35%), Positives = 201/364 (54%), Gaps = 19/364 (5%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLY 60
M++ +L+ E N D S N++YL+ + V++ +Y L Y
Sbjct: 1 MKVKEVQELIKEKNLDAFMFSSQPNVFYLSRFR-----STNAYAVITPQEKYLLTDARYY 55
Query: 61 S---NVITNFPVTFWRDGENPYAKLSTILGELKL-YRGRFLVEDTMRADWLIGILKLGNF 116
N + ++ V + N + + L E L Y G E+ + LK +
Sbjct: 56 ERAKNQLKDWEVVLIKG--NLFKSVKNFLREKGLKYVG---YEEDRVSCTFKKHLKSKHI 110
Query: 117 EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIR 176
+ S+ ++ +R+ K +EEI MK R +DK++ E+L++ GM+E ++ I +I
Sbjct: 111 RWVGFSNFLKNVRVLKTKEEISIMKEGVRKSDKIYRELLNFVKPGMTELQVRGFIVSKIF 170
Query: 177 ELS-DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGR 235
E + +G SF IVASGE+SA PH E KI++ +++D G W GYC+D TRT +G+
Sbjct: 171 EKNGEGESFPAIVASGEHSAVPHWESSREKIKENAPLLIDMGLLWEGYCTDFTRTFHIGK 230
Query: 236 PDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLD 295
P E+ +VYEIVKEA +A + G +VD+ ARE I + GYG++FTH TGHG+G++
Sbjct: 231 PSEEFRKVYEIVKEAHLRALEKAKVGNTVGDVDRAAREYIEKKGYGQFFTHSTGHGVGVE 290
Query: 296 VHEEP---YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVE-GKGKRLTKAGRE 351
+HE P Y G D + +E GM FTIEPGIY+PG GVR+E+ V V+ G GK L++ E
Sbjct: 291 IHEFPRVYYKGDDAKTPIEEGMVFTIEPGIYLPGKFGVRLENIVAVQGGVGKPLSEIDLE 350
Query: 352 LITV 355
L+ +
Sbjct: 351 LVVI 354
>pir||G72425 hypothetical protein TM0042 - Thermotoga maritima (strain MSB8)
>gi|4980527|gb|AAD35136.1|AE001691_10 (AE001691)
aminopeptidase P, putative [Thermotoga maritima]
Length = 359
Score = 207 bits (522), Expect = 1e-52
Identities = 104/244 (42%), Positives = 159/244 (64%), Gaps = 2/244 (0%)
Query: 114 GNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEV 173
G+ +F + ++ MRM KD EIE +K A I+++ F E + GM+EKE+A +E
Sbjct: 116 GDRKFIGIDDEVKQMRMVKDEGEIEKIKQAIEISERAFLETVQQIRAGMTEKEIAALLEY 175
Query: 174 RIR-ELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIA 232
+R E ++GV+F IVASG SA PH + ++ + +GD++++D+GA + YC+DITR ++
Sbjct: 176 TMRKEGAEGVAFDTIVASGCRSALPHGKASDKVVERGDVIVIDFGATYENYCADITRVVS 235
Query: 233 VGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGL 292
+G P +++ EV+ IV EAQE+A + + G+ K +D VARE I E GYGE+F H GHG+
Sbjct: 236 IGEPSDEVKEVHSIVLEAQERALKIAKAGVTGKLLDSVAREFIREKGYGEFFGHSLGHGI 295
Query: 293 GLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAGRE 351
GL+VHE P I + L + FT+EPGIY+ G G+RIE+DVV++ +G + LT R
Sbjct: 296 GLEVHEGPAISFRNDSPLPENVVFTVEPGIYLEGKFGIRIEEDVVLKEQGCEILTTLPRS 355
Query: 352 LITV 355
+ V
Sbjct: 356 IFVV 359
>emb|CAB07979.1| (Z93945) prolidase-related protein [Lactobacillus delbrueckii]
Length = 373
Score = 207 bits (522), Expect = 1e-52
Identities = 132/338 (39%), Positives = 194/338 (57%), Gaps = 19/338 (5%)
Query: 10 LNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYSNVITNFP- 68
L+E D A+++ ++ YLTG ER L+VS G+ LLAP++ +
Sbjct: 20 LDEKGIDLAYVAEPVDIAYLTGYSSW-TEERVFALLVSRTGQALLLAPAINEGEVKQTSW 78
Query: 69 ---VTFWRDGENPYAKLSTILGELK----LYRGRFLVEDTMRADWLIGILKLGNFEFHPL 121
F++DGENP+ K + R + RA + + N +
Sbjct: 79 ADRACFYQDGENPWEKAKKRMTAWPKGFWALEARAVTLSHYRA--IKEVFPEANLA-SDI 135
Query: 122 SSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL----GMSEKELALKIEVRIRE 177
S+ + RM K EIE ++ A R+AD+ + L++ +L GMSE ELAL+++ ++++
Sbjct: 136 STWLARQRMIKSPAEIEKLQAAGRLADQALD--LAFALLKAGQGMSESELALELDYQLKK 193
Query: 178 LSDG-VSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRP 236
G +SF IV +GE++A+ P ++ ++ GDIVI D G GY SD++RT+A+G
Sbjct: 194 KGMGDLSFPLIVQAGESAASISGLPSQKGVQAGDIVIFDLGIMKDGYASDVSRTVALGEI 253
Query: 237 DEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDV 296
E+YE V+ AQE A RA R G+ A E+D+VAR VI EAGYG+YFTHR GHG+G+ V
Sbjct: 254 SPAKWEIYETVRLAQETAARAARPGMTAGELDQVARGVIEEAGYGQYFTHRLGHGIGMQV 313
Query: 297 HEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIED 334
HE + P + LE GM F+IEPGIY+PG+GGVRIED
Sbjct: 314 HEPVNLEPGSKQKLEAGMCFSIEPGIYLPGVGGVRIED 351
>pir||G69869 Xaa-Pro dipeptidase homolog ykvY - Bacillus subtilis
>gi|2633757|emb|CAB13259.1| (Z99111) similar to Xaa-Pro
dipeptidase [Bacillus subtilis]
Length = 363
Score = 205 bits (516), Expect = 7e-52
Identities = 133/362 (36%), Positives = 188/362 (51%), Gaps = 13/362 (3%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
RI R L E AFI N++YLTG E ER L + + E + P + +
Sbjct: 3 RIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYT-EPHERLMGLFIFQEEEPFFVCPGMEA 61
Query: 62 ----NVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVE----DTMRADWLIGILKL 113
N N + + D ENP+ + L + + VE RA+ L
Sbjct: 62 GQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAVEKDSISLSRAEQLKHAT-- 119
Query: 114 GNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEV 173
G +F + R+ KD EI +K AA++AD E + G+SE E+ +IE
Sbjct: 120 GGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVGTAALREGISEVEVLAQIEY 179
Query: 174 RIRELS-DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIA 232
+++ G+SFS +V GE S PH PG ++KGD V+ D G GYCSDITRT A
Sbjct: 180 ELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDFVLFDLGVILDGYCSDITRTFA 239
Query: 233 VGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGL 292
+ K +YE V +A++ A A + G++ ++D AR +I +AGYG+YF HR GHGL
Sbjct: 240 YKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDLTARGIIEKAGYGDYFPHRLGHGL 299
Query: 293 GLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGK-RLTKAGRE 351
G+ VHE P + + L+ GM +TIEPGIY+P +GGVRIEDDV V G LT+ ++
Sbjct: 300 GISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEIGGVRIEDDVHVTKDGAVALTQYPKD 359
Query: 352 LI 353
LI
Sbjct: 360 LI 361
>emb|CAA70068.1| (Y08842) aminopeptidase P [Lactococcus lactis]
Length = 352
Score = 205 bits (515), Expect = 9e-52
Identities = 137/366 (37%), Positives = 199/366 (53%), Gaps = 25/366 (6%)
Query: 1 MRIDRF-VKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVS------ADGEYK 53
MRI++ VK+L E N D I+ N++YLTG G T+ + D Y
Sbjct: 1 MRIEKLKVKMLTE-NIDSLLITDMKNIFYLTGFS----GTAGTVFLTQKRNIFMTDSRYS 55
Query: 54 LLAPSLYSNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKL 113
+A L I NF + RD P + L+ + + F E+T+ + + K
Sbjct: 56 EMARGL----IKNFEIIETRD---PISLLTELSASESVKNMAF--EETVDYAFFKRLSKA 106
Query: 114 GN-FEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIE 172
+ S+ + +R KD EI +K A IAD+ F L + G +E E+A ++
Sbjct: 107 ATKLDLFSTSNFVLELRQIKDESEISLIKKACEIADEAFMSALRFIEPGRTEIEVANFLD 166
Query: 173 VRIREL-SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTI 231
++R+L + G+SF IVASG+ S+ PH + I+ GD V +D+G + Y SD+TRTI
Sbjct: 167 FKMRDLEASGISFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTI 226
Query: 232 AVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHG 291
VG D+K+ +YE V++A E + V+ G+ + D + REVI +A +G+YFTH GHG
Sbjct: 227 FVGSVDDKMRTIYETVRKANEALIKQVKAGMTYAQYDNIPREVIEKADFGQYFTHGIGHG 286
Query: 292 LGLDVHEEPYIGPD-GEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAG 349
LGLDVHE PY E L +GM T EPGIY+P GGVRIEDD++V G + LTKA
Sbjct: 287 LGLDVHEIPYFNQSMTENQLRSGMVITDEPGIYLPEFGGVRIEDDLLVTENGCEVLTKAP 346
Query: 350 RELITV 355
+ELI +
Sbjct: 347 KELIVI 352
>sp|O84913|PEPQ_LACHE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE)
>gi|3282339|gb|AAC24966.1| (AF012084) prolidase
[Lactobacillus helveticus]
Length = 368
Score = 204 bits (514), Expect = 1e-51
Identities = 132/366 (36%), Positives = 204/366 (55%), Gaps = 19/366 (5%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLY 60
M +D+ + L + N D A+IS + Y TG + + ER L+V D + P+L
Sbjct: 1 MNLDKLQQWLQDSNNDIAYISNPITISYFTGYSM-DPHERIFALLVFKDANPFIFCPALN 59
Query: 61 ----SNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVE----DTMRADWLIGILK 112
N N V + D E+P+ ++ + + + +E +L G
Sbjct: 60 VEEAKNSEWNGDVFGYLDSEDPWELIADNVRKRTSDTHTWAIEKDDLSVAHYQYLRGEFP 119
Query: 113 LGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL--GMSEKELALK 170
+F + +SS I +R+ K EEI+ ++ A AD F+ + +D + G++E+ +A +
Sbjct: 120 NASFT-NDVSSFIERLRLYKTPEEIKKLQGAGAEADFAFK--IGFDAIRTGVTERSIAGQ 176
Query: 171 IEVRIRELSDGV---SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDI 227
I+ +++ + GV SF IV +G+N+ANPH P ++ ++V+ D G GY SD
Sbjct: 177 IDYQLK-IQKGVMHESFETIVQAGKNAANPHLGPTMNTVQPNELVLFDLGTMHDGYASDS 235
Query: 228 TRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHR 287
+RT+A G P +K E+YE+ +EAQ+ A A + GI A+E+D VAR++I++AGYGEYF HR
Sbjct: 236 SRTVAYGTPSDKQREIYEVDREAQQAAIEAAKPGITAEELDSVARDIITKAGYGEYFIHR 295
Query: 288 TGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLT 346
GHG+G +VHE P I ++ LE GM F+IEPGIYIPG GVRIED VV G K T
Sbjct: 296 LGHGIGKNVHEYPSIVQGNDLVLEEGMCFSIEPGIYIPGFAGVRIEDCGVVTKDGFKTFT 355
Query: 347 KAGREL 352
++L
Sbjct: 356 HTDKDL 361
>emb|CAB07978.1| (Z93944) prolidase [Lactobacillus delbrueckii]
Length = 368
Score = 202 bits (508), Expect = 6e-51
Identities = 130/365 (35%), Positives = 200/365 (54%), Gaps = 17/365 (4%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSL- 59
M +D+ L E D A++S + + Y TG + + ER L D E L P+L
Sbjct: 1 MNLDKLQNWLQENGMDVAYVSSPTTINYFTGF-ITDPEERIFKLFAFKDAEPFLFCPALN 59
Query: 60 YSNVITNF---PVTFWRDGENPYAKLSTILGELKLYRGRFLVEDT--MRADWLIGILKLG 114
Y + V + D E+P+ K++ + + + VE A + +
Sbjct: 60 YEEAKASAWDGDVVGYLDSEDPWGKIAEEIKQRSKDYQNWAVEKNGLTVAHYQALHAQFP 119
Query: 115 NFEFHP-LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL--GMSEKELALKI 171
+ +F LS I +R+ K E+ ++ A AD F+ + ++ L G++E+ + +I
Sbjct: 120 DSDFSKDLSDFIAHIRLFKTESELVKLRKAGEEADFAFQ--IGFEALRNGVTERAVVSQI 177
Query: 172 EVRIRELSDGV---SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDIT 228
E +++ L GV SF IV +G+N+ANPH P ++ ++V+ D G GY SD +
Sbjct: 178 EYQLK-LQKGVMQTSFDTIVQAGKNAANPHQGPSMNTVQPNELVLFDLGTMHEGYASDSS 236
Query: 229 RTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRT 288
RT+A G P +K+ E+YE+ + AQ+ A A + G+ A E+D VAR++I++AGYGEYF HR
Sbjct: 237 RTVAYGEPTDKMREIYEVNRTAQQAAIDAAKPGMTASELDGVARKIITDAGYGEYFIHRL 296
Query: 289 GHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTK 347
GHG+G++VHE P I +V LE GM F+IEPGIYIPG GVRIED V+ +G K T
Sbjct: 297 GHGIGMEVHEFPSIANGNDVVLEEGMCFSIEPGIYIPGFAGVRIEDCGVLTKEGFKPFTH 356
Query: 348 AGREL 352
+EL
Sbjct: 357 TSKEL 361
>sp|Q9S6S1|PEPQ_LACDE XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE)
>gi|3821250|emb|CAA73815.1| (Y13385) proline dipeptidase
[Lactobacillus delbrueckii subsp. bulgaricus]
Length = 368
Score = 202 bits (508), Expect = 6e-51
Identities = 131/365 (35%), Positives = 203/365 (54%), Gaps = 17/365 (4%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSL- 59
M +D+ L E D A++S + + Y TG + + ER L D E L P+L
Sbjct: 1 MNLDKLQNWLQENGMDVAYVSSPTTINYFTGF-ITDPEERIFKLFAFKDAEPFLFCPALN 59
Query: 60 YSNVITNF---PVTFWRDGENPYAKLST-ILGELKLYRGRFLVEDTMR-ADWLIGILKLG 114
Y + V + D E+P+ K++ I K Y+ + ++ + A + +
Sbjct: 60 YEEAKASAWDGDVVGYLDSEDPWGKIAEEIKQRTKDYQNWAVEKNGLTVAHYQALHAQFP 119
Query: 115 NFEFHP-LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL--GMSEKELALKI 171
+ +F LS I +R+ K E+ ++ A AD F+ + ++ L G++E+ + +I
Sbjct: 120 DSDFSKDLSDFIAHIRLFKTESELVKLRKAGEEADFAFQ--IGFEALRNGVTERAVVSQI 177
Query: 172 EVRIRELSDGV---SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDIT 228
E +++ L GV SF IV +G+N+ANPH P ++ ++V+ D G GY SD +
Sbjct: 178 EYQLK-LQKGVMQTSFDTIVQAGKNAANPHQGPSMNTVQPNELVLFDLGTMHEGYASDSS 236
Query: 229 RTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRT 288
RT+A G P +K+ E+YE+ + AQ+ A A + G+ A E+D VAR++I++AGYGEYF HR
Sbjct: 237 RTVAYGEPTDKMREIYEVNRTAQQAAIDAAKPGMTASELDGVARKIITDAGYGEYFIHRL 296
Query: 289 GHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTK 347
GHG+G++VHE P I +V LE GM F+IEPGIYIPG GVRIED V+ +G K T
Sbjct: 297 GHGIGMEVHEFPSIANGNDVVLEEGMCFSIEPGIYIPGFAGVRIEDCGVLTKEGFKPFTH 356
Query: 348 AGREL 352
+EL
Sbjct: 357 TSKEL 361
>sp|P46545|PEPQ_LACDL XAA-PRO DIPEPTIDASE (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE)
(PROLIDASE) (IMIDODIPEPTIDASE) >gi|1075982|pir||S52202
X-Pro dipeptidase (EC 3.4.13.9) [validated] -
Lactobacillus delbrueckii >gi|609078|emb|CAA84379.1|
(Z34896) prolidase [Lactobacillus delbrueckii]
>gi|1150454|emb|CAA90911.1| (Z54205) prolidase PepQ
[Lactobacillus delbrueckii]
Length = 368
Score = 201 bits (507), Expect = 8e-51
Identities = 131/365 (35%), Positives = 203/365 (54%), Gaps = 17/365 (4%)
Query: 1 MRIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSL- 59
M +D+ L E D A++S + + Y TG + + ER L D E L P+L
Sbjct: 1 MNLDKLQNWLQENGMDVAYVSSPTTINYFTGF-ITDPEERIFKLFAFKDAEPFLFCPALN 59
Query: 60 YSNVITNF---PVTFWRDGENPYAKLST-ILGELKLYRGRFLVEDTMR-ADWLIGILKLG 114
Y + V + D E+P++K++ I K Y+ + ++ + A + +
Sbjct: 60 YEEAKASAWDGDVVGYLDSEDPWSKIAEEIKKRTKDYQNWAVEKNGLTVAHYQALHAQFP 119
Query: 115 NFEFHP-LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL--GMSEKELALKI 171
+ +F LS I +R+ K E+ ++ A AD F+ + ++ L G++E+ + +I
Sbjct: 120 DSDFSKDLSDFIAHIRLFKTESELVKLRKAGEEADFAFQ--IGFEALRNGVTERAVVSQI 177
Query: 172 EVRIRELSDGV---SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDIT 228
E +++ L GV SF IV +G+N+ANPH P ++ ++V+ D G GY SD +
Sbjct: 178 EYQLK-LQKGVMQTSFDTIVQAGKNAANPHQGPSMNTVQPNELVLFDLGTMHEGYASDSS 236
Query: 229 RTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRT 288
RT+A G P +K+ E+YE+ + AQ+ A A + G+ A E+D VAR++I++AGYGEYF HR
Sbjct: 237 RTVAYGEPTDKMREIYEVNRTAQQAAIDAAKPGMTASELDGVARKIITDAGYGEYFIHRL 296
Query: 289 GHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTK 347
GHG+G++VHE P I +V LE GM F+IEPGIYIPG GVRIED V+ G K T
Sbjct: 297 GHGIGMEVHEFPSIANGNDVVLEEGMCFSIEPGIYIPGFAGVRIEDCGVLTKDGFKPFTH 356
Query: 348 AGREL 352
+EL
Sbjct: 357 TSKEL 361
>gb|AAD53120.1|AF176799_2 (AF176799) PepQ [Lactobacillus pentosus]
Length = 369
Score = 198 bits (498), Expect = 9e-50
Identities = 126/352 (35%), Positives = 197/352 (55%), Gaps = 22/352 (6%)
Query: 16 DGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYSNVITN----FPVTF 71
D +IS + YLTG + + ER L V AD E L AP+L I + V
Sbjct: 20 DVTYISNFHTISYLTGFESNPY-ERTLGLFVFADAEPFLFAPALEVEAIKEMGWPYKVFG 78
Query: 72 WRDGENPYAKLSTILGEL-------KLYRGRFLVEDTMRADWLIGILKLGNFEFHPLSSL 124
+ D E+PYA ++T + E L G ++ R + L +F+ LS
Sbjct: 79 YLDHEDPYALIATHIQEQLTDPKSWALEAGNLTLD---RFNALKAQFPAAHFD-KDLSPY 134
Query: 125 IRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGV-- 182
I+ +R+ K +E+E + A + AD FE+ + G +E+++A +++ + + G+
Sbjct: 135 IQQLRLVKTADELEKLNIAGKWADFAFEQGFAAVKAGRTEQQIAAELQYAL--MKKGIME 192
Query: 183 -SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLI 241
SF +V +GE++ANPH E +++ ++V+ D G + GY SD +RTIA G+P +K
Sbjct: 193 MSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASRTIAYGQPTDKQK 252
Query: 242 EVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPY 301
E++++ EA A A++ G+ A++VDK+AR++I++AGYGEYF HR GHG+G HE P
Sbjct: 253 EIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLGHGIGQTDHEFPS 312
Query: 302 IGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAGREL 352
I + L GM F++EPGIYIPG+ GVRIED VV +G K T +E+
Sbjct: 313 IMAGNHMPLVEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHTPKEM 364
>pir||D75419 proline dipeptidase - Deinococcus radiodurans (strain R1)
>gi|6458990|gb|AAF10817.1|AE001972_7 (AE001972) proline
dipeptidase [Deinococcus radiodurans]
Length = 349
Score = 194 bits (487), Expect = 2e-48
Identities = 122/352 (34%), Positives = 187/352 (52%), Gaps = 28/352 (7%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGE--YKLLAPSL 59
++D+ +L D ++S +N+ +L+G E G+ ++VS DG Y ++
Sbjct: 3 KMDQLRPVLGRAGVDALWVSAPANVRWLSGFTSAEDGK----VLVSPDGATLYTDARYTV 58
Query: 60 YSNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVE---DTMRADWLIGILKLGNF 116
+ ++ P R T+ G + L + +R W
Sbjct: 59 QAQEESSLPQYIARPPATYEHAADTVRGLRVGFEAESLTVAELEDLRQAW---------- 108
Query: 117 EFHPLSSLIRL------MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALK 170
P S+L+ L +R K EEI ++ A +AD+V+ E+ G+ E ++A++
Sbjct: 109 ---PNSTLVALRGTLGGLRAVKTPEEIGAIRAAQDLADRVYTEVRPMIRAGVRELDVAVE 165
Query: 171 IEVRIRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRT 230
IE R+R +F IVASG N A PH +R I GD+V +D GAR GY SD+TRT
Sbjct: 166 IETRLRRAGGESAFELIVASGPNGAKPHGHASKRVIEDGDLVTIDMGARLGGYNSDMTRT 225
Query: 231 IAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGH 290
+AVG P ++ VY+ V EA+E A A+R G++A ++DK+AR++++ G GE F H GH
Sbjct: 226 VAVGTPSAEMKRVYDAVLEAEEAAIAAIRPGVRAADLDKLARDLLTRHGLGEAFAHSLGH 285
Query: 291 GLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG 342
G+GL+VHE P + + LE GM TIEPG Y+PG+GGVRIED ++V G
Sbjct: 286 GVGLEVHEGPGLRGTSQDVLEAGMVITIEPGAYLPGVGGVRIEDLILVTEDG 337
>pir||F65012 hypothetical protein b2385 - Escherichia coli (strain K-12)
>gi|1788728|gb|AAC75444.1| (AE000326) putative peptidase
[Escherichia coli K12]
Length = 361
Score = 194 bits (487), Expect = 2e-48
Identities = 101/228 (44%), Positives = 145/228 (63%), Gaps = 6/228 (2%)
Query: 127 LMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL-SDGVSFS 185
++R K EE+E ++ A IAD+ E I + GMSE+E+A ++E +R+ ++ SF
Sbjct: 123 VLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFD 182
Query: 186 PIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTI-----AVGRPDEKL 240
IVASG A PH + ++ + G+ V LD+GA ++GYCSD+TRT+ V L
Sbjct: 183 TIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHLL 242
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
VY+IV +AQ A A+R G++ ++VD AR VI+EAGYG+YF H TGH +G++VHE+P
Sbjct: 243 FNVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDP 302
Query: 301 YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKA 348
P TL+ GM T+EPGIY+PG GGVRIED V+V +G + A
Sbjct: 303 RFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYA 350
>dbj|BAA16255.1| (D90868) PUTATIVE PEPTIDASE IN GCVT-SPOIIIAA INTERGENIC REGION (EC
3.4.-.-). [Escherichia coli]
Length = 262
Score = 194 bits (487), Expect = 2e-48
Identities = 101/228 (44%), Positives = 145/228 (63%), Gaps = 6/228 (2%)
Query: 127 LMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL-SDGVSFS 185
++R K EE+E ++ A IAD+ E I + GMSE+E+A ++E +R+ ++ SF
Sbjct: 24 VLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFD 83
Query: 186 PIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTI-----AVGRPDEKL 240
IVASG A PH + ++ + G+ V LD+GA ++GYCSD+TRT+ V L
Sbjct: 84 TIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHLL 143
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
VY+IV +AQ A A+R G++ ++VD AR VI+EAGYG+YF H TGH +G++VHE+P
Sbjct: 144 FNVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDP 203
Query: 301 YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKA 348
P TL+ GM T+EPGIY+PG GGVRIED V+V +G + A
Sbjct: 204 RFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYA 251
>pir||B72032 proline dipeptidase CP1058 [imported] - Chlamydophila pneumoniae
(strains CWL029 and AR39) >gi|4377125|gb|AAD18951.1|
(AE001662) Aminopeptidase P [Chlamydophila pneumoniae
CWL029] >gi|7189972|gb|AAF38831.1| (AE002263) proline
dipeptidase [Chlamydophila pneumoniae AR39]
>gi|8979187|dbj|BAA99021.1| (AP002548) aminopeptidase P
[Chlamydophila pneumoniae J138]
Length = 355
Score = 184 bits (463), Expect = 1e-45
Identities = 120/356 (33%), Positives = 189/356 (52%), Gaps = 13/356 (3%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKL--LAPSL 59
RI R + L+E N D + +L Y LH+ +L+ + + + + L
Sbjct: 5 RILRAQRALSEHNLDAILVEKSEDLAYF----LHDEAIAGILLIGQQEVMFFVYRMDKDL 60
Query: 60 YSNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFH 119
YS+ I P+TF ++ A LS + + + + F T+ + + +E
Sbjct: 61 YSH-IQRVPLTFLT--QDVVADLSLYVQKQRYQKIGFDSASTVYHKFAQRQVLPCLWE-- 115
Query: 120 PLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL- 178
PL +R K EEI M+ AA + ++ +L+ G++EKE+ ++ E
Sbjct: 116 PLECFTEKIRSIKSEEEIRRMQEAAALGSAGYDYVLTLLREGITEKEVVRQLRAFWAEAG 175
Query: 179 SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDE 238
++G SF PI+A GE+SA PH P +R ++KGDIV++D G GYCSD+TR A+G P
Sbjct: 176 AEGPSFPPIIAFGEHSAFPHSIPTDRPLKKGDIVLIDIGVLLNGYCSDMTRMTALGTPHP 235
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHE 298
KL+E Y +V EAQ++A +EG+ ++D A V+ E YF H GHG+G +HE
Sbjct: 236 KLLESYPVVVEAQKRAMALCKEGVLWGDIDAEAVRVLREHHLDTYFIHGIGHGVGRHIHE 295
Query: 299 EPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELIT 354
P +V LE+GMT T+EPG+Y PG+GG+RIED + ++ K K + R +I+
Sbjct: 296 YPCSPRGSQVKLESGMTITVEPGVYFPGIGGIRIEDTLCID-KNKNFSLTARPVIS 350
>pir||C70658 probable pepQ - Mycobacterium tuberculosis (strain H37RV)
>gi|1781067|emb|CAB06173.1| (Z83863) pepQ [Mycobacterium
tuberculosis]
Length = 372
Score = 182 bits (457), Expect = 6e-45
Identities = 126/370 (34%), Positives = 193/370 (52%), Gaps = 29/370 (7%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLK------LHEVGERPTILVVSADGEYKLL 55
R D+ + D IS N+ YL+G L ER +L + DG Y+
Sbjct: 6 RRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLVFADERDAVL--ATDGRYRTQ 63
Query: 56 APSLYSNVITNFPVTFWR-----DGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGI 110
A S ++ R GE KL + + D + D L G
Sbjct: 64 AASQAPDLEVAIERAVGRYLAGRAGEAGVGKLG--------FESHVVTVDGL--DALAGA 113
Query: 111 LKLGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL--GMSEKELA 168
L+ N E S + +R KD E+ ++ A AD ++++ L G +E++++
Sbjct: 114 LEGKNTELVRASGTVESLREVKDAGELALLRLACEAADAALTDLVARGGLRPGRTERQVS 173
Query: 169 LKIEVRIREL-SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDI 227
++E + + +D VSF IVA+G NSA PHH P + ++ GD V +D+GA GY SD+
Sbjct: 174 RELEALMLDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYHSDM 233
Query: 228 TRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHR 287
TRT +G+ + +E+Y++V EAQ+ +A+ G + + VD AR++I++AGYGE+F H
Sbjct: 234 TRTFVLGKAADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLIADAGYGEHFGHG 293
Query: 288 TGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTK 347
GHG+GL +HE P IG TL G T+EPG+Y+PG GGVRIED +VV G ++ +
Sbjct: 294 LGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVVAGGTPKMPE 353
Query: 348 -AGR--ELIT 354
AG+ EL+T
Sbjct: 354 TAGQTPELLT 363
>pir||H71496 probable aminopeptidase P - Chlamydia trachomatis (serotype D,
strain UW3/Cx) >gi|3329016|gb|AAC68176.1| (AE001328)
Aminopeptidase P [Chlamydia trachomatis]
Length = 356
Score = 179 bits (449), Expect = 5e-44
Identities = 94/239 (39%), Positives = 142/239 (59%), Gaps = 3/239 (1%)
Query: 116 FEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI 175
+ F P S + +R K EEI+ M AA I ++ +L+ G++EKEL + V
Sbjct: 112 YAFSPQSLVAEKLRCVKSTEEIQKMTRAAEIGSAGYDFVLAALRPGITEKELVRMLHVFW 171
Query: 176 RELS-DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVG 234
L + VSF PI+A GEN+A PH P R ++KGD+V++D G + GYCSD+TRT+A G
Sbjct: 172 ANLGIEKVSFPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFG 231
Query: 235 R-PDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLG 293
P+++L++ Y V EAQ A R G+ ++V K A ++ G + F H GHG+G
Sbjct: 232 ATPEQQLLDGYVAVAEAQRAAIEFCRAGVPCRDVHKEAVRILRAHGMEKAFIHGLGHGVG 291
Query: 294 LDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGREL 352
+VHE P + P + TL+ M T+EPG+Y PG+GG+RIED +++ G + L R++
Sbjct: 292 REVHEYPRLSPFSDATLQLNMAVTVEPGVYFPGVGGIRIEDTIMI-GVNENLNLTNRKV 349
>gb|AAK40693.1| Prolidase (Xaa-Pro dipeptidase) (pepQ) [Sulfolobus solfataricus]
Length = 352
Score = 177 bits (445), Expect = 1e-43
Identities = 100/226 (44%), Positives = 144/226 (63%), Gaps = 10/226 (4%)
Query: 122 SSLIRLMRMRKDREEIENMKHAARI---ADKVFEEILSWDILGMSEKELALKIEVRIREL 178
+ ++RL + KD +EIE ++ A I A K+ E LS +EK++A I++ +R +
Sbjct: 122 NEIVRLREV-KDNDEIERIRKAGEITAVAMKIGMEKLSEGT--SNEKQVAGIIDMTMRSM 178
Query: 179 -SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPD 237
++ +F IVA GENSA PHH P +R + DIV+ D GA++ GYC D TRT +
Sbjct: 179 GAEDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVFKNSE 238
Query: 238 EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVH 297
K +VYE+V EAQ +A AVR+G+ A EVD AR VI +AGYG+YF H TGHG+G+++H
Sbjct: 239 AK--KVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIH 296
Query: 298 EEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGK 343
E P + + + L+ M T+EPGIY+ G G+RIED ++V KGK
Sbjct: 297 ESPAVSMNSKQILKENMIITVEPGIYLKGRFGIRIEDTLIVT-KGK 341
>pir||F82878 XAA-PRO aminopeptidase UU532 [imported] - Ureaplasma urealyticum
>gi|6899536|gb|AAF30945.1|AE002152_4 (AE002152) XAA-PRO
aminopeptidase [Ureaplasma urealyticum]
Length = 357
Score = 174 bits (436), Expect = 2e-42
Identities = 93/223 (41%), Positives = 133/223 (58%), Gaps = 3/223 (1%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGV-SFSP 186
+R K +E+E ++ AA IA I DI+G +E E+A + + EL + SF P
Sbjct: 131 LRAIKTEKELEYLQKAADIAALTCNWIREQDIIGRTELEIATLVSKHMLELGGELNSFDP 190
Query: 187 IVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVG-RPDEKLIEVYE 245
I+ASG N +PHH PG R I GD+V +D G ++GYCSDITR+ VG + + ++ E+Y+
Sbjct: 191 IIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKANPQMQEIYD 250
Query: 246 IVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGPD 305
V E+Q + + +EVDKV R+++ + + YFTH TGHG+GL VHE P
Sbjct: 251 KVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQVHELPNTNAG 310
Query: 306 GEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV-EGKGKRLTK 347
L T+EPGIYIP +GGVRIED +VV +G+ LT+
Sbjct: 311 NPNKLPLNAVVTVEPGIYIPNVGGVRIEDTIVVKDGQALVLTR 353
>sp|Q58216|Y806_METJA HYPOTHETICAL PEPTIDASE MJ0806 >gi|2129355|pir||F64400 X-Pro
dipeptidase (EC 3.4.13.9) - Methanococcus jannaschii
>gi|1591498|gb|AAB98806.1| (U67525) X-pro aminopeptidase
(pepQ) [Methanococcus jannaschii]
Length = 347
Score = 172 bits (431), Expect = 6e-42
Identities = 123/360 (34%), Positives = 190/360 (52%), Gaps = 42/360 (11%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVG-----ERPTILVVSADGEYKLLA 56
RI+RF+K + A I N+ Y G E+P + V D +Y
Sbjct: 12 RIERFLKYMESEGIKKAVILKKENINYFLGKYFMSFSVLVFEEQPYLYVGKLDKDY---- 67
Query: 57 PSLYSNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNF 116
E + L + E K + F D + + IG LK +
Sbjct: 68 ------------------AEEHFNFLE--IREFKSWEEIFKGCDGVEKELSIGYLKYIDK 107
Query: 117 EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILS--WDILGMSEKELALKIE-V 173
E+ +S I+ MRM KD+EEI+ +K AA I+DK +L+ ++ ++E EL +IE +
Sbjct: 108 EYKIISDKIKEMRMIKDKEEIKLIKKAAEISDKAINWVLNNLDEVKNLTEYELVAEIEYI 167
Query: 174 RIRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV 233
+ S +F IV SG+ ++ PH P + KI DI+++D GA + GYCSDITRT +
Sbjct: 168 MKKHGSIKPAFDSIVVSGKKTSFPHALPTKDKI--ADILLVDIGAVYEGYCSDITRTFLL 225
Query: 234 GRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLG 293
+ DE++ ++Y +V EA++ A ++EGI AK++D + RE ++ Y E F H GHG+G
Sbjct: 226 -KDDEEMKKIYNLVYEAKKVAEEHLKEGISAKQIDNIVREFFND--YKELFIHSLGHGVG 282
Query: 294 LDVHEEPYIG----PDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKA 348
L+VHEEP + D ++ L+ GM TIEPG+Y+ GVRIED +V+ G ++L+KA
Sbjct: 283 LEVHEEPRLSNKLKDDEDIILKEGMVVTIEPGLYLKDKFGVRIEDLYLVKKNGFEKLSKA 342
>pir||F81657 proline dipeptidase TC0863 [imported] - Chlamydia muridarum
(strain Nigg) >gi|7190889|gb|AAF39659.1| (AE002352)
proline dipeptidase [Chlamydia muridarum]
Length = 356
Score = 172 bits (431), Expect = 6e-42
Identities = 92/237 (38%), Positives = 140/237 (58%), Gaps = 3/237 (1%)
Query: 118 FHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRE 177
F P S + +R K EI+ M AA I ++ +L+ G++EKEL + V
Sbjct: 114 FSPQSLVTEKLRCVKSPNEIQKMMRAAEIGSAGYDFVLAALRPGITEKELVRLLHVFWAN 173
Query: 178 LS-DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGR- 235
L + +SF PI+A GEN+A PH P R ++KGD+V++D G + GYCSD+TRT+A G
Sbjct: 174 LGIEKLSFPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGEA 233
Query: 236 PDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLD 295
P+++L++ Y V EAQ ++ REG+ + V + A V+ E G + F H GHG+G +
Sbjct: 234 PEQQLLDGYLAVAEAQRRSIELCREGVSCRAVHEEAVRVLREYGMEKAFIHGLGHGVGRE 293
Query: 296 VHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGREL 352
VHE P + + L+ M T+EPG+Y PG+GG+RIED +V+ G + L R++
Sbjct: 294 VHEYPRLSLFSDAELQLNMAVTVEPGVYFPGVGGIRIEDTIVI-GINENLNLTNRKV 349
>pir||E64649 probable X-Pro dipeptidase (EC 3.4.13.9) - Helicobacter pylori
(strains 26695 and NCTC 11637)
>gi|2314181|gb|AAD08080.1| (AE000611) conserved
hypothetical protein [Helicobacter pylori 26695]
Length = 357
Score = 169 bits (425), Expect = 3e-41
Identities = 97/239 (40%), Positives = 136/239 (56%), Gaps = 19/239 (7%)
Query: 126 RLMRMRKDREEIENMKHAARIADKVFEEILSW------DILGMSEKELALKI-EVRIREL 178
R R+ K+ EI+ +K + + + FE + + +SE+ L K+ + RE
Sbjct: 118 RQKRIIKNEHEIQLLKKSQALNVEAFENFAEYVKKIFDEKESLSERYLQHKVKDFLTREG 177
Query: 179 SDGVSFSPIVASGENSANPHHEPGERKIRKGD-IVILDYGARWRGYCSDITRTIAVGRPD 237
+SF PI+A N++ PH P + K + ++LD G ++ YCSD TRT D
Sbjct: 178 VYDLSFEPILALNANASKPHALPSAKDFLKAEHSILLDMGIKYERYCSDRTRTAFFDPKD 237
Query: 238 -----------EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTH 286
++ ++Y+IVKEAQEKA +R G+ KE D +AR VIS+ GYG+YFTH
Sbjct: 238 FVFKREQSFKDKERQKIYDIVKEAQEKAISGIRAGMTGKEADSLARGVISDYGYGQYFTH 297
Query: 287 RTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRL 345
TGHG+GLD+HE PYI E LE GM F++EPGIYIPG GVRIED VV++ L
Sbjct: 298 STGHGIGLDIHELPYISSRSETILEEGMVFSVEPGIYIPGFFGVRIEDLVVIKNSRSEL 356
>pir||A71938 probable proline peptidase - Helicobacter pylori (strain J99)
>gi|4154912|gb|AAD05960.1| (AE001473) putative proline
peptidase [Helicobacter pylori J99]
Length = 357
Score = 169 bits (425), Expect = 3e-41
Identities = 99/239 (41%), Positives = 135/239 (56%), Gaps = 19/239 (7%)
Query: 126 RLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELA----LKIEVRIRELSDG 181
R R+ K+ EI+ +K + + + FE + EKE L+ +V+ +G
Sbjct: 118 RQKRIIKNEHEIQLLKKSQALNVEAFENFAEYVKKIFDEKESLSERYLQHKVKDFLTKEG 177
Query: 182 V---SFSPIVASGENSANPHHEPGERKIRKGD-IVILDYGARWRGYCSDITRTIAVGRPD 237
V SF PI+A N++ PH P + K D ++LD G ++ YCSD TRT D
Sbjct: 178 VYDLSFEPILALNANASKPHALPSAKDFLKADHSILLDMGIKYERYCSDRTRTAFFDPKD 237
Query: 238 -----------EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTH 286
++ ++Y+IVKEAQEKA +R G+ KE D +AR VIS+ GYG+YFTH
Sbjct: 238 FVFKREQSFKDKERQKIYDIVKEAQEKAISGIRAGMTGKEADSLARGVISDYGYGQYFTH 297
Query: 287 RTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRL 345
TGHG+GLD+HE PYI E LE GM F++EPGIYIPG GVRIED VV++ L
Sbjct: 298 STGHGIGLDIHELPYISSRSETILEEGMVFSVEPGIYIPGFFGVRIEDLVVIKNSRAEL 356
>pir||A72750 probable Xaa-Pro dipeptidase APE0526 - Aeropyrum pernix (strain
K1) >gi|5104177|dbj|BAA79493.1| (AP000059) 349aa long
hypothetical Xaa-Pro dipeptidase [Aeropyrum pernix]
Length = 349
Score = 169 bits (423), Expect = 6e-41
Identities = 96/234 (41%), Positives = 142/234 (60%), Gaps = 8/234 (3%)
Query: 122 SSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELA-LKIEVRIRELSD 180
S LI +R K+ EI + AARIA+ + G+SE+E+A ++V ++
Sbjct: 117 SQLISQVRSVKEEWEIGLIAEAARIAEAALRRGIEELREGVSEREVAGAVVDVIMKSGGW 176
Query: 181 GVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
G SF IVA G N+A PHH G+ ++ V+ D G+ ++GY SD+TR++ G +
Sbjct: 177 GPSFPVIVAFGGNTALPHHHTGDARLPHASPVLFDLGSVYKGYMSDMTRSLWRGPGGAEY 236
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
+ E+V EAQ +A +V G++A EVDK AR +S+ G+ +YF H TGHG+G+++HE P
Sbjct: 237 RRLEELVAEAQAEAIDSVAPGVEAWEVDKAARLRLSKEGFSKYFIHGTGHGVGVEIHENP 296
Query: 301 YIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELIT 354
Y+ P L+ GM TIEPG+Y+PG+ GVRIED V+V TK GR+L+T
Sbjct: 297 YLRPGSSEELKPGMVVTIEPGVYLPGMYGVRIEDMVLV-------TKRGRKLLT 343
>pir||D69231 probable X-Pro dipeptidase (EC 3.4.13.9) - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622080|gb|AAB85477.1| (AE000871) aminopeptidase P
[Methanobacterium thermoautotrophicum]
Length = 336
Score = 168 bits (420), Expect = 1e-40
Identities = 101/223 (45%), Positives = 134/223 (59%), Gaps = 11/223 (4%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL-SDGVSFSP 186
+RM KDREE++ M+ A RIA+ F+++ +E E+A +++ +R S+GVSF
Sbjct: 121 IRMVKDREELKRMEEALRIAENSFKKLE----FNGTEIEIAARLDYTMRLAGSEGVSFDT 176
Query: 187 IVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYEI 246
IVAS E S+ PH P I V++D+GA GY SD TRTI G + EV EI
Sbjct: 177 IVASSERSSIPHAVPTANTIESP--VLIDWGAVREGYHSDTTRTIVEGEGEH---EVLEI 231
Query: 247 VKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGPDG 306
V EA+ +A++ G +A +VD R VI E GY + F H TGHG+GLDVHE+P +
Sbjct: 232 VLEAKRAGVKALKPGARACDVDSAVRGVIGEYGYADNFIHSTGHGVGLDVHEKPSLAAGD 291
Query: 307 EVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV-EGKGKRLTKA 348
E L GM T+EPGIYIPG GVR+ED VVV +G RL A
Sbjct: 292 ETVLRKGMVLTVEPGIYIPGEFGVRVEDMVVVGDGVMNRLPDA 334
>sp|P75313|AMPP_MYCPN PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE)
(AMINOPEPTIDASE P) (APP) (AMINOACYLPROLINE
AMINOPEPTIDASE) >gi|2146699|pir||S73697 probable X-Pro
dipeptidase (EC 3.4.13.9) pepX - Mycoplasma pneumoniae
(strain ATCC 29342) >gi|1674050|gb|AAB96019.1|
(AE000035) X-Pro dipeptidase [Mycoplasma pneumoniae]
Length = 354
Score = 163 bits (408), Expect = 3e-39
Identities = 88/215 (40%), Positives = 126/215 (57%), Gaps = 3/215 (1%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGV-SFSP 186
+R +K EI ++ I KV ++ + GM+E +A I ++ + SF P
Sbjct: 125 IRRQKLPSEILAIEKVVEITRKVAVKLKRFIQPGMTELFIAQWITDQLVKAGGAKNSFDP 184
Query: 187 IVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRP--DEKLIEVY 244
IVA+G+N ANPHH+P + K++ GD V D+G + GYCSDITRT VG+ +E L++ Y
Sbjct: 185 IVATGKNGANPHHKPSKLKVKSGDFVTCDFGTIYNGYCSDITRTFLVGKKPNNEVLLKAY 244
Query: 245 EIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGP 304
+ V EA A + EVDKV R++I + + +YF H TGHG+GLD+HE P +
Sbjct: 245 KKVDEANMAGINAANTQLTGAEVDKVCRDIIEASEFKDYFVHSTGHGVGLDIHEMPNVST 304
Query: 305 DGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVE 339
L TIEPGIYIP +GG+RIED V+V+
Sbjct: 305 SYNKLLCENAVITIEPGIYIPSVGGIRIEDMVLVK 339
>emb|CAB93372.1| (AL357523) putative peptidase [Streptomyces coelicolor A3(2)]
Length = 368
Score = 162 bits (405), Expect = 7e-39
Identities = 86/237 (36%), Positives = 140/237 (58%), Gaps = 6/237 (2%)
Query: 121 LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL-S 179
L + +R+ KD EEI ++ A IAD+ E+L ++G +E+ LAL++E R+ + +
Sbjct: 128 LGQAVEQLRVVKDEEEISCLRIGAEIADQALGELLESILVGRTERHLALELERRLVDHGA 187
Query: 180 DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGR-PDE 238
DG +F V +G NS H P +R++ +GD + + GA +RGY +I RT +G P +
Sbjct: 188 DGPAFPTSVGTGPNSGRRGHRPTDRRVEEGDFLSVCLGATYRGYRCEIGRTFVIGTSPAD 247
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHE 298
IE+Y++V AQ A+ G ++VD+ AR+ + AGY E+ TGHG+GL++ E
Sbjct: 248 WQIELYDLVFSAQRAGREALAPGAACRDVDRAARQPLDSAGYAEHLPALTGHGVGLEIDE 307
Query: 299 EPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELITV 355
+P + P L+ + T+EPG+++PG GGVRI+D +VV + G EL+T+
Sbjct: 308 DPQLAPAAMGKLDACVPVTVEPGVHLPGRGGVRIDDTLVVRPE----ADGGPELLTI 360
>sp|P47566|AMPP_MYCGE PUTATIVE XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE)
(AMINOPEPTIDASE P) (APP) (AMINOACYLPROLINE
AMINOPEPTIDASE) >gi|1361898|pir||H64235 X-Pro
aminopeptidase (EC 3.4.11.9) - Mycoplasma genitalium
>gi|3844901|gb|AAC71546.1| (U39713) aminopeptidase P
(pepP) [Mycoplasma genitalium]
Length = 354
Score = 157 bits (394), Expect = 1e-37
Identities = 75/160 (46%), Positives = 108/160 (66%), Gaps = 4/160 (2%)
Query: 183 SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDE--KL 240
SF PIVA+G+N ANPHH+P + +++GD + D+G + GYCSDITRT VG+ + KL
Sbjct: 181 SFDPIVATGKNGANPHHKPTKTIVKEGDFITCDFGTIYNGYCSDITRTFLVGKKPKSAKL 240
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
+ Y+ V+EA AV + +VDKV R++I + + ++F H TGHG+G+D+HE P
Sbjct: 241 LSAYKKVEEANLAGINAVNTTLTGSQVDKVCRDIIENSEFKDFFVHSTGHGVGIDIHEMP 300
Query: 301 YIGPD-GEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVE 339
+ ++ ENG+ TIEPGIYIP LGG+RIED V+V+
Sbjct: 301 NVSQSYNKLLCENGVV-TIEPGIYIPNLGGIRIEDMVLVK 339
>pir||T39750 probable dipeptidase - fission yeast (Schizosaccharomyces pombe)
>gi|5263087|emb|CAB45933.1| (AL080287) hypothetical
dipeptidase; metallopeptidase family
[Schizosaccharomyces pombe]
Length = 451
Score = 154 bits (386), Expect = 1e-36
Identities = 113/356 (31%), Positives = 169/356 (46%), Gaps = 29/356 (8%)
Query: 5 RFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVG--ERPTILVVSADGEY---------- 52
R L E D + P ++ Y + G ERP + ++ +D E
Sbjct: 83 RLSAALREDKLDALIMEPTVSMDYFANITTGSWGLSERPFLGIIFSDDEPYPGDVASRIY 142
Query: 53 ----KLLAPSLYSNVITNFPVTF--WRDGENPYAKLSTILGELKLYRGRFLVEDTMRADW 106
K P V N + W + ENPY L LG LKL +++ T+R ++
Sbjct: 143 FLVPKFELPRAKELVGKNIDAKYITWDEDENPYQVLYDRLGPLKL-----MIDGTVR-NF 196
Query: 107 LIGILKLGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKE 166
+ L+ F +S + +R K E++ M + G++EKE
Sbjct: 197 IAQGLQYAGFTTFGVSPRVASLREIKSPAEVDIMSRVNIATVAAIRSVQPCIKPGITEKE 256
Query: 167 LALKIEVRIRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSD 226
LA I + V SPIV GE +A PH P R+++K + V++D G GY SD
Sbjct: 257 LAEVINMLFVYGGLPVQESPIVLFGERAAMPHGGPSNRRLKKSEFVLMDVGTTLFGYHSD 316
Query: 227 ITRTIAVG--RPDEKLIEVYEIVKEAQEKAYRAVRE--GIKAKEVDKVAREVISEAGYGE 282
TRT+ + E++ +++ +V +AQ + + EVD AR+VI +AGYGE
Sbjct: 317 CTRTVLPHGQKMTERMEKLWNLVYDAQTAGIQMLSHLSNTSCAEVDLAARKVIKDAGYGE 376
Query: 283 YFTHRTGHGLGLDVHEEPYIGPDGEVT-LENGMTFTIEPGIYIPGLGGVRIEDDVV 337
YF HR GHGLGL+ HE+ Y+ P + T ++ G FT+EPGIYIP G+RIED V+
Sbjct: 377 YFIHRLGHGLGLEEHEQTYLNPANKGTPVQKGNVFTVEPGIYIPDEIGIRIEDAVL 432
>pir||A83084 probable metallopeptidase PA4498 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9950737|gb|AAG07886.1|AE004863_6 (AE004863) probable
metallopeptidase [Pseudomonas aeruginosa]
Length = 405
Score = 145 bits (362), Expect = 8e-34
Identities = 111/355 (31%), Positives = 166/355 (46%), Gaps = 29/355 (8%)
Query: 10 LNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYSNVITNFPV 69
+ E A++ GSNL Y +G++ H ER ++ A+G + LAP+ + +F V
Sbjct: 43 MGEHGIAAAYLHAGSNLRYFSGVQWHP-SERLVGALLPAEGALEYLAPAFEEGTVRDFQV 101
Query: 70 T-----FWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFE------- 117
W + ++PY L L L + + L L G FE
Sbjct: 102 VDGAIHTWEEHQDPYRLLLDRLEALGVGERSTVA--------LCPSLPFGMFERLRQQAP 153
Query: 118 ---FHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVR 174
F + LI RMRK EE+ M+ A + +V + S G+S E+A I
Sbjct: 154 GRNFVSAAPLIDQGRMRKSAEELALMQRAKDMTLEVQKAAASILREGISTTEVAEFIHQA 213
Query: 175 IRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVG 234
R++ S IV G SA PH + ++ GD+V++D G + GY SDITR+ G
Sbjct: 214 HRKVGAPGSTFCIVLFGAASAFPHGVKHAQVLKDGDMVLIDTGCQVHGYQSDITRSYVFG 273
Query: 235 RPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYF-----THRTG 289
P + E + + ++AQ A+ A R G + VD AR + G G + HRTG
Sbjct: 274 TPSARQREFWGMERDAQLAAFEAARLGQPCEAVDAAARRSLEANGLGPDYRLPGLPHRTG 333
Query: 290 HGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKR 344
HG+G+DVHE PY+ L+ GM F+ EP I +PG G+R+ED + +G R
Sbjct: 334 HGIGMDVHEGPYLVRGDRTPLDVGMCFSNEPMICVPGEFGIRLEDHFYMTKEGPR 388
>pir||H82833 proline dipeptidase XF0220 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9105027|gb|AAF83033.1|AE003875_8 (AE003875)
proline dipeptidase [Xylella fastidiosa]
Length = 400
Score = 133 bits (332), Expect = 3e-30
Identities = 102/355 (28%), Positives = 170/355 (47%), Gaps = 19/355 (5%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAP---- 57
RI++ L+ D + G++L Y TG+ H ER L++ G+ L+ P
Sbjct: 35 RIEQARVLMRIQGVDALLVGAGASLRYFTGVPWH-ASERLVALLILLSGDPLLICPVFEE 93
Query: 58 -SLYSNVITNFPVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNF 116
SL + ++ W + E+PYA ++ ++ E + R L D+ A + + +
Sbjct: 94 GSLDAVLLLPVGKRLWEEHEDPYALVAQVMRE---HGARTLALDS-GATFAVHTGLCRHV 149
Query: 117 EFHPLSSLIRLM---RMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEV 173
+ ++ ++ R+ K E+ ++ A + +V G+ + I+
Sbjct: 150 DARAITDATAIVDGCRLCKSPAELALIQQACDMTLQVQRLAAGIAHEGIGTDAMVRFIDE 209
Query: 174 RIREL-SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIA 232
R L +D S IV G+ +A PH PG + + +G +V++D G +GY SDITRT
Sbjct: 210 AHRALGADNGSTFCIVQFGQATAFPHGIPGVQHLVEGQLVLIDTGCTVQGYHSDITRTWI 269
Query: 233 VGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYF-----THR 287
G+P + ++++ + AQ A+ AVR G+ + VD+ AR+V+ G G + HR
Sbjct: 270 YGKPSDHQRRIWDLEQAAQAAAFAAVRPGVACEVVDRAARQVLELGGLGPDYRLPGLPHR 329
Query: 288 TGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG 342
TGHG GL +HE PY+ L GM + EP I +PG GVR+ED V G
Sbjct: 330 TGHGCGLAIHEAPYLVRGNHTVLCPGMCASDEPMIVVPGHFGVRLEDHFYVTEDG 384
>gi|11499616 X-pro aminopeptidase (pepQ) [Archaeoglobus fulgidus]
>gi|7445466|pir||A69504 X-pro aminopeptidase (pepQ)
homolog - Archaeoglobus fulgidus
>gi|2648501|gb|AAB89220.1| (AE000962) X-pro
aminopeptidase (pepQ) [Archaeoglobus fulgidus]
Length = 363
Score = 128 bits (318), Expect = 1e-28
Identities = 102/348 (29%), Positives = 174/348 (49%), Gaps = 44/348 (12%)
Query: 21 SPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSL----------YSNVITNFPVT 70
S +N YY T K ++ P + DG L+ P + +++ +
Sbjct: 20 SSNANFYYATKFKTYD----PLTYIAGIDGSDILIVPEMEKKRAERESRVKEIVSLNDLG 75
Query: 71 FWRD----GENPYAKLSTILGELKLYRGR-FLVEDTMRADWLIGILKLGNFEFHPLSSLI 125
+ G+ A L ++ LK R R L+ + M ++K +FE + +
Sbjct: 76 YMEKLKELGDAKKAYLEILVAILKEGRCRKLLIPEEMPTYISFELMK--HFEVEVVKNPF 133
Query: 126 RLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKEL-ALKIEVRIRELSDG-VS 183
+R+ K E+E ++ + + W + S + ++ + ++ S+G ++
Sbjct: 134 STLRIIKSSSEVEKIRDTSN----AILRCVKWAVENFSFRTCEGMRRAIELKLFSEGYLA 189
Query: 184 FSPIVASGENSANPHHEPGERKIRKGDI---VILDYGARWRG--YCSDITRTIAVGRPDE 238
+ I ++G++SA+PH +I KG+I V+LD + Y SD TRT+ V R +
Sbjct: 190 ENTICSTGKSSADPH------EIGKGEIEEHVVLDVFPKSLDHLYYSDFTRTLFV-RENA 242
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGY----GEYFTHRTGHGLGL 294
+L E+Y+ V +AQEKA +R+G+ AK+V + ++ ++ G+ GE F H TGHG+GL
Sbjct: 243 ELEEMYKAVVDAQEKALSMIRDGVDAKDVHQAVKDTLNSHGFKTEKGEGFIHSTGHGVGL 302
Query: 295 DVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG 342
+VHEEP I + V L+ GM T+EPG+Y +GGVR+ED VVV G
Sbjct: 303 EVHEEPRIS-ELSVELKKGMVVTVEPGLYYSKVGGVRVEDTVVVRKNG 349
>gb|AAG10442.1|AF279106_4 (AF279106) predicted Xaa-Pro aminopeptidase [uncultured
proteobacterium EBAC31A08]
Length = 431
Score = 118 bits (294), Expect = 7e-26
Identities = 78/251 (31%), Positives = 132/251 (52%), Gaps = 30/251 (11%)
Query: 122 SSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKEL-ALKIEVRIRELSD 180
SS++ +R+ KD+ EI+ MK A I+ + + E++ G +E+E+ AL + +
Sbjct: 161 SSMVGNLRLIKDKHEIDIMKRACEISAESYIEVMKSIKPGDNEQEIEALFLYEFAKRGGR 220
Query: 181 GVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEK 239
+++PIVA GE + H+ ++++ D++++D G ++ Y SDITRT V G+ ++
Sbjct: 221 FPAYTPIVAGGEGACVLHYIENDKELASSDLILVDAGCEYKMYASDITRTFPVSGKFSDE 280
Query: 240 LIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISE------------------AGYG 281
+++Y IV +A A AV+ G E V+ +VI+E +
Sbjct: 281 QLQIYNIVHKANLAAIDAVKTGNSIMEPQMVSEKVITEGLVELGILSGDVNQLHKNGAFK 340
Query: 282 EYFTHRTGHGLGLDVHE-EPYIGPDGEVTLENGMTFTIEPGIYIPGLG---------GVR 331
+++ H+ GH LGLDVH+ Y+ D + + GM TIEPGIYI G+R
Sbjct: 341 DFYMHKVGHWLGLDVHDVGDYMEGDEFMKFKPGMITTIEPGIYISSAMDVDDKWKGIGIR 400
Query: 332 IEDDVVVEGKG 342
IEDD++V G
Sbjct: 401 IEDDILVTDSG 411
>sp|P15034|AMPP_ECOLI XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE) (AMINOPEPTIDASE P II)
(APP-II) (AMINOACYLPROLINE AMINOPEPTIDASE)
>gi|67530|pir||DPECP X-Pro aminopeptidase (EC 3.4.11.9)
II - Escherichia coli >gi|216529|dbj|BAA00299.1|
(D00398) aminopeptidase P precursor [Escherichia coli]
>gi|216627|dbj|BAA14325.1| (D90281) PepP (proline amino
peptidaseII) [Escherichia coli]
>gi|882438|gb|AAA69076.1| (U28377) ORF_f441; third start
codon [Escherichia coli] >gi|1789275|gb|AAC75946.1|
(AE000374) proline aminopeptidase P II [Escherichia coli
K12] >gi|363847|prf||1505351A aminopeptidase P
[Escherichia coli]
Length = 441
Score = 115 bits (284), Expect = 1e-24
Identities = 86/261 (32%), Positives = 125/261 (46%), Gaps = 38/261 (14%)
Query: 124 LIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI-RELSDGV 182
++ MR+ K EEI ++ A I + GM E L +I R +
Sbjct: 169 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 228
Query: 183 SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEKLI 241
S++ IV SGEN H+ E ++R GD+V++D G ++GY DITRT V G+ +
Sbjct: 229 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 288
Query: 242 EVYEIVKEAQEKAYRAVREGIKAKEV-DKVAR-----------------EVISEAGYGEY 283
E+Y+IV E+ E + R R G EV +V R E+I++ + +
Sbjct: 289 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 348
Query: 284 FTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP----------GLGGVRIE 333
F H H LGLDVH+ G D LE GM T+EPG+YI G+ G+RIE
Sbjct: 349 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGI-GIRIE 407
Query: 334 DDVVVEGKGKRLTKAGRELIT 354
DD+V+ T+ G E +T
Sbjct: 408 DDIVI-------TETGNENLT 421
>pdb|1A16| Aminopeptidase P From E. Coli With The Inhibitor Pro-Leu
Length = 440
Score = 115 bits (284), Expect = 1e-24
Identities = 86/261 (32%), Positives = 125/261 (46%), Gaps = 38/261 (14%)
Query: 124 LIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI-RELSDGV 182
++ MR+ K EEI ++ A I + GM E L +I R +
Sbjct: 168 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 227
Query: 183 SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEKLI 241
S++ IV SGEN H+ E ++R GD+V++D G ++GY DITRT V G+ +
Sbjct: 228 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 287
Query: 242 EVYEIVKEAQEKAYRAVREGIKAKEV-DKVAR-----------------EVISEAGYGEY 283
E+Y+IV E+ E + R R G EV +V R E+I++ + +
Sbjct: 288 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 347
Query: 284 FTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP----------GLGGVRIE 333
F H H LGLDVH+ G D LE GM T+EPG+YI G+ G+RIE
Sbjct: 348 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGI-GIRIE 406
Query: 334 DDVVVEGKGKRLTKAGRELIT 354
DD+V+ T+ G E +T
Sbjct: 407 DDIVI-------TETGNENLT 420
>pdb|1AZ9| Aminopeptidase P From E. Coli
Length = 457
Score = 115 bits (284), Expect = 1e-24
Identities = 86/261 (32%), Positives = 125/261 (46%), Gaps = 38/261 (14%)
Query: 124 LIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI-RELSDGV 182
++ MR+ K EEI ++ A I + GM E L +I R +
Sbjct: 185 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 244
Query: 183 SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEKLI 241
S++ IV SGEN H+ E ++R GD+V++D G ++GY DITRT V G+ +
Sbjct: 245 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 304
Query: 242 EVYEIVKEAQEKAYRAVREGIKAKEV-DKVAR-----------------EVISEAGYGEY 283
E+Y+IV E+ E + R R G EV +V R E+I++ + +
Sbjct: 305 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 364
Query: 284 FTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP----------GLGGVRIE 333
F H H LGLDVH+ G D LE GM T+EPG+YI G+ G+RIE
Sbjct: 365 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGI-GIRIE 423
Query: 334 DDVVVEGKGKRLTKAGRELIT 354
DD+V+ T+ G E +T
Sbjct: 424 DDIVI-------TETGNENLT 437
>pdb|1JAW| Aminopeptidase P From E. Coli Low Ph Form
Length = 440
Score = 115 bits (284), Expect = 1e-24
Identities = 86/261 (32%), Positives = 125/261 (46%), Gaps = 38/261 (14%)
Query: 124 LIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI-RELSDGV 182
++ MR+ K EEI ++ A I + GM E L +I R +
Sbjct: 168 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 227
Query: 183 SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEKLI 241
S++ IV SGEN H+ E ++R GD+V++D G ++GY DITRT V G+ +
Sbjct: 228 SYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 287
Query: 242 EVYEIVKEAQEKAYRAVREGIKAKEV-DKVAR-----------------EVISEAGYGEY 283
E+Y+IV E+ E + R R G EV +V R E+I++ + +
Sbjct: 288 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPF 347
Query: 284 FTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP----------GLGGVRIE 333
F H H LGLDVH+ G D LE GM T+EPG+YI G+ G+RIE
Sbjct: 348 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGI-GIRIE 406
Query: 334 DDVVVEGKGKRLTKAGRELIT 354
DD+V+ T+ G E +T
Sbjct: 407 DDIVI-------TETGNENLT 420
>gb|AAB96776.1| (AF041033) aminopeptidase [Shigella flexneri]
Length = 441
Score = 112 bits (278), Expect = 6e-24
Identities = 85/261 (32%), Positives = 124/261 (46%), Gaps = 38/261 (14%)
Query: 124 LIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI-RELSDGV 182
++ MR+ K EEI ++ A I + GM E L +I R +
Sbjct: 169 VVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYP 228
Query: 183 SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEKLI 241
S++ IV SGEN H+ E ++R GD+V++D G ++GY DITRT V G+ +
Sbjct: 229 SYNTIVGSGENGCILHYTENESELRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQR 288
Query: 242 EVYEIVKEAQEKAYRAVREGIKAKEV-DKVAR-----------------EVISEAGYGEY 283
E+Y+IV E+ E + R R G EV +V R E+I++ + +
Sbjct: 289 EIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGNVDELIAQNAHRPF 348
Query: 284 FTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP----------GLGGVRIE 333
F H H LGLDVH+ G D LE GM T+EP +YI G+ G+RIE
Sbjct: 349 FMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPVLYIAPDADVPEQYRGI-GIRIE 407
Query: 334 DDVVVEGKGKRLTKAGRELIT 354
DD+V+ T+ G E +T
Sbjct: 408 DDIVI-------TETGNENLT 421
>pir||F82609 aminopeptidase P XF2009 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9107124|gb|AAF84811.1|AE004020_2 (AE004020)
aminopeptidase P [Xylella fastidiosa]
Length = 446
Score = 112 bits (277), Expect = 7e-24
Identities = 83/257 (32%), Positives = 123/257 (47%), Gaps = 32/257 (12%)
Query: 117 EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIR 176
EF L L+ R+ K +EI ++ AA I+ + L + G+SE L ++E R
Sbjct: 168 EFIDLGHLLHEQRLFKSYDEIVLLQCAADISVEAHLAALRYAHPGVSEYVLQAELERVFR 227
Query: 177 ELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GR 235
+++ IVA+G N+ H+ R GD+V++D GA +RGY +DITRT V GR
Sbjct: 228 AADSCPAYTSIVAAGANACVLHYRANAECSRDGDLVLIDAGAEYRGYAADITRTFPVNGR 287
Query: 236 PDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEA----------------- 278
+Y++V A A R G+ + A + ++E
Sbjct: 288 FSPAQRALYDLVGAAYNVALAQARPGLPYEAGHLAAVQTLTEGLLRLGLLHGTLEDNLAD 347
Query: 279 -GYGEYFTHRTGHGLGLDVHEEPYIGPDGEV-TLENGMTFTIEPGIYI-----------P 325
Y ++ H+TGH LGLDVH+ DGE LE GM FTIEPG+Y+
Sbjct: 348 QSYKRFYRHKTGHWLGLDVHDVGDYRIDGESRLLEPGMVFTIEPGLYVLPDDTAVHPKWR 407
Query: 326 GLGGVRIEDDVVVEGKG 342
G+ G+R EDDV++ G
Sbjct: 408 GI-GIRTEDDVLITEDG 423
>pir||H82992 aminopeptidase P PA5224 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9951532|gb|AAG08609.1|AE004935_6
(AE004935) aminopeptidase P [Pseudomonas aeruginosa]
Length = 444
Score = 109 bits (271), Expect = 4e-23
Identities = 82/259 (31%), Positives = 124/259 (47%), Gaps = 35/259 (13%)
Query: 117 EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIR 176
EF L L+ R+ K E++ M++AA ++ + + G+ E L ++E R
Sbjct: 161 EFVALDHLLHDQRLYKSANEVKVMRYAAEVSARAHIRAMEVCRPGLFEYHLEAELEYEFR 220
Query: 177 ELSDGV-SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTI-AVG 234
+ + ++ IVA+G N+ H+ + I+ GD++++D G Y SDITRT A G
Sbjct: 221 KGGAKMPAYGSIVAAGRNACILHYRENDAAIKDGDLILIDAGCEIDCYASDITRTFPANG 280
Query: 235 RPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKV------------------AREVIS 276
R + +YE+V EA A+ + G E + E+I+
Sbjct: 281 RFSPEQKAIYELVLEANMAAFDYIAPGRHWNEAHEATVRVITAGLVRLGLLEGDVDELIA 340
Query: 277 EAGYGEYFTHRTGHGLGLDVHE--EPYIGPDGEVTLENGMTFTIEPGIYIP--------- 325
Y ++ HR GH LG+DVH+ E +G + V LE GM T+EPGIYI
Sbjct: 341 HEAYKAFYMHRAGHWLGMDVHDVGEYRVGGEWRV-LEPGMAMTVEPGIYIAPDNTTVAKK 399
Query: 326 --GLGGVRIEDDVVVEGKG 342
G+ GVRIEDDVVV G
Sbjct: 400 WRGI-GVRIEDDVVVTRNG 417
>gb|AAG19595.1| (AE005049) X-pro aminopeptidase homolog; PepQ2 [Halobacterium sp.
NRC-1]
Length = 391
Score = 109 bits (269), Expect = 6e-23
Identities = 68/182 (37%), Positives = 91/182 (49%), Gaps = 12/182 (6%)
Query: 172 EVRIRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRG--YCSDITR 229
E+ I L G + + +G A HE G + D V++D R + Y SD+TR
Sbjct: 198 EIEIELLRHGCALDDTIVAGGAQAADAHERGSGPLPADDPVVVDIFPRSKDSKYHSDMTR 257
Query: 230 TIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFT---- 285
T A G P + E Y + + A E A A+ G+ + V++ +V + GY F
Sbjct: 258 TFANGDPSDAHRERYAVTRAAFEAALDAIEPGVTGEAVNQAVIDVFDDHGYPNVFADPDT 317
Query: 286 -----HRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEG 340
H TGHG+GLDVHE P + G+ L G TIEPG+Y PG GGVRIED VVV
Sbjct: 318 ESGFIHSTGHGVGLDVHEMPAVSQGGD-ELHAGNVITIEPGLYEPGEGGVRIEDIVVVTE 376
Query: 341 KG 342
G
Sbjct: 377 DG 378
>pir||B75217 x-pro dipeptidase PAB2178 - Pyrococcus abyssi (strain Orsay)
>gi|5457694|emb|CAB49185.1| (AJ248283) x-pro dipeptidase
[Pyrococcus abyssi]
Length = 365
Score = 105 bits (260), Expect = 7e-22
Identities = 101/356 (28%), Positives = 163/356 (45%), Gaps = 34/356 (9%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
R++RF +LL E N DGA I S+ Y TG K RP++L+ A+GE +L +
Sbjct: 18 RVERFQELLRENNIDGAVIRTLSSFIYFTGTKWL----RPSLLI-PAEGEPTVLVVKGEA 72
Query: 62 NVITNFPVTFWRDGENPYAKLSTILGELKLY-----RGRFLVEDTMRADWLIGILKL--- 113
+ F W + Y K+ ++ + + R +E + D + K+
Sbjct: 73 EL---FKQRSWIEDVVEYQKVEELMATVVKWIKDNGMKRVGLEFGIERDAYLIFYKIFLR 129
Query: 114 --GNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADK---VFEEILSWDILGMSEKELA 168
+ E + L +RM KD E+EN++ A +IA K V EE + G SE E+A
Sbjct: 130 LNPSIEVVDILDLTMSLRMIKDEWELENIRKAGKIALKGMRVAEEEIK---PGKSELEIA 186
Query: 169 LKIEVRIRELSDGVSFSPIVASGENSANPHHEP-GERKIRKGDIVILDYGARWRGYCSDI 227
++ +REL S P V + H EP + K+ + IV + G W Y +++
Sbjct: 187 AEV---VRELMLNGSEDPKVYVSV-TPRAHAEPFRDLKVPENGIVTVVIGTDWNHYYANM 242
Query: 228 TRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHR 287
RT VG P E++ + E+ KEA + A R G+ V+K E G+GEY
Sbjct: 243 ARTFIVGDPGERVKKAIEVKKEALKLALEETRVGVPISAVEKKIEHFFKERGFGEYHLAG 302
Query: 288 TGHGLGLDVHEEP---YIGPDGEVTLENGMTFT-IEPGIYIPGLGGVRIEDDVVVE 339
HG+GL + E P + P ++ M + I P + +P G ++ E+ +V+
Sbjct: 303 YTHGVGLLIEEPPIATIVVPQRATRIQENMVLSIIHPPLMLPE-GAIKYENTYIVK 357
>sp|P44881|AMPP_HAEIN XAA-PRO AMINOPEPTIDASE (X-PRO AMINOPEPTIDASE) (AMINOPEPTIDASE P II)
(APP-II) (AMINOACYLPROLINE AMINOPEPTIDASE)
>gi|1073841|pir||B64096 X-Pro aminopeptidase (EC
3.4.11.9) II - Haemophilus influenzae (strain Rd KW20)
>gi|1573829|gb|AAC22475.1| (U32764) aminopeptidase P
(pepP) [Haemophilus influenzae Rd]
Length = 430
Score = 104 bits (256), Expect = 2e-21
Identities = 78/251 (31%), Positives = 120/251 (47%), Gaps = 31/251 (12%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI-RELSDGVSFSP 186
MR+ K EI M+ A +I + + E E+ I R + S++
Sbjct: 166 MRLIKSPNEIRLMQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNS 225
Query: 187 IVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEKLIEVYE 245
IVA G N+ H+ +R + GD+V++D G + Y DITRT V G+ + E+YE
Sbjct: 226 IVAGGSNACILHYTENDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYE 285
Query: 246 IVKEAQEKAYRAVREGIKAKEV-DKVAR-----------------EVISEAGYGEYFTHR 287
+V +AQ++A + G K+ D+V R +I + Y +++ H
Sbjct: 286 LVLKAQKRAIELLVPGNSIKQANDEVIRIKTQGLVDLGILKGDVDTLIEQQAYRQFYMHG 345
Query: 288 TGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYI----------PGLGGVRIEDDVV 337
GH LGLDVH+ G D + LE GM T+EPGIYI G+ GVRIED+++
Sbjct: 346 LGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGI-GVRIEDNLL 404
Query: 338 VEGKGKRLTKA 348
+ G ++ A
Sbjct: 405 MTEYGNKILTA 415
>pir||S76440 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1653657|dbj|BAA18569.1| (D90915) aminopeptidase P
[Synechocystis sp.]
Length = 441
Score = 103 bits (255), Expect = 3e-21
Identities = 80/262 (30%), Positives = 122/262 (46%), Gaps = 41/262 (15%)
Query: 119 HPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIR-E 177
HPL + +R K E+ ++ A ++ + + + G E ++ ++E+ R E
Sbjct: 166 HPL---VHPLRQVKSETELALLRRACDLSAIAHQRAMEFARPGHYEYQVQAELEIIFRRE 222
Query: 178 LSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRP 236
G ++ IVA+G+N+ H+ + ++ GD++++D G + Y DITRT + G+
Sbjct: 223 GGLGPAYPSIVAAGKNACILHYINNDCPLQDGDLLLIDAGCAYGYYNGDITRTFPINGKF 282
Query: 237 DEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVA------------------REVISEA 278
+ +YEIV AQE A V+ G E A E+I E
Sbjct: 283 SPEQRTLYEIVLTAQEAAIAKVQAGNPYHEYHDAAVSVIVDGLMDLGLLVGNKEEIIKEE 342
Query: 279 GYGEYFTHRTGHGLGLDVHEEPYIGPDGE--VTLENGMTFTIEPGIYI-----PGLG--- 328
Y ++ HRTGH LGLDVH+ D E LE G T+EPGIYI P G
Sbjct: 343 KYKPFYMHRTGHWLGLDVHDAGNYKQDKETWTVLEPGQVLTVEPGIYIAPDIKPAEGQPE 402
Query: 329 --------GVRIEDDVVVEGKG 342
G+RIEDDV+V +G
Sbjct: 403 VPEQWRGIGIRIEDDVLVTAQG 424
>gi|11559925 hypothetical protein LOC63929 [Homo sapiens]
>gi|9188414|emb|CAB97210.1| (AL365514) hypothetical
protein [Homo sapiens]
Length = 507
Score = 103 bits (255), Expect = 3e-21
Identities = 84/248 (33%), Positives = 118/248 (46%), Gaps = 33/248 (13%)
Query: 121 LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL-S 179
+ LI+ +R+ K EIE M+ A ++ + F E + + E L K E R +
Sbjct: 236 VQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA 295
Query: 180 DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDE 238
D +++ P+VA G S H+ + I+ G++V+LD G Y SDITRT V GR
Sbjct: 296 DILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTA 355
Query: 239 KLIEVYEIVKEAQ-------------EKAY----RAVREGIKAKEVDKVAREVISEAGYG 281
E+YE V E Q E Y + + +K + K +E +
Sbjct: 356 PQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAAR 415
Query: 282 EYFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP-----------GLGGV 330
+Y H GH LG+DVH+ P + + L+ GM TIEPGIYIP GL GV
Sbjct: 416 KYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGL-GV 472
Query: 331 RIEDDVVV 338
RIEDDVVV
Sbjct: 473 RIEDDVVV 480
>pir||D71204 hypothetical protein PH1902 - Pyrococcus horikoshii
>gi|3258344|dbj|BAA31027.1| (AP000007) 365aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 365
Score = 102 bits (252), Expect = 6e-21
Identities = 98/359 (27%), Positives = 163/359 (45%), Gaps = 34/359 (9%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
R++RF +LL E N DGA I S+ Y TG K RP++L+ A+GE ++L +
Sbjct: 18 RVERFQELLKENNIDGAVIRTLSSFIYFTGTKWL----RPSLLI-PAEGEPRVLVVKGEA 72
Query: 62 NVITNFPVTFWRDGENPYAKLSTIL---------GELKLYRGRFLVEDTMRADWLIGILK 112
+ F W + Y K ++ E+K F +E + L+
Sbjct: 73 EL---FKERSWIEDVVEYQKAEELMLTVVKWIRENEMKRVGLEFGIERDAYLIFYKIFLR 129
Query: 113 LG-NFEFHPLSSLIRLMRMRKDREEIENMKHAARIADK---VFEEILSWDILGMSEKELA 168
L E + L +RM KD E++N++ A +IA K V EE + G +E E+A
Sbjct: 130 LNPTVEVVDILDLTMKLRMIKDEWELDNIRKAGKIALKGMRVAEEEIK---PGRTELEIA 186
Query: 169 LKIEVRIRELSDGVSFSPIVASGENSANPHHEP-GERKIRKGDIVILDYGARWRGYCSDI 227
++ REL S P V + H EP + K+ + +V + G W Y +++
Sbjct: 187 AEVT---RELMLNGSEDPKVYVSV-TPRAHAEPFRDLKVPENGVVTVVIGTDWNHYYANM 242
Query: 228 TRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHR 287
RT +G P E++ + E+ KEA + A + G+ V+K + E G+G+Y
Sbjct: 243 ARTFIIGDPGERVKKAIEVKKEAIKLALEETKVGVPISTVEKKIEQFFKERGFGDYHLSG 302
Query: 288 TGHGLGLDVHEEP---YIGPDGEVTLENGMTFT-IEPGIYIPGLGGVRIEDDVVVEGKG 342
HG+GL + E P + P ++ M + I P + +P G ++ E+ +V+ G
Sbjct: 303 YTHGVGLLIEEPPIATIVVPQRAAKIQENMVLSIIHPPLMLPE-GAIKYENTYIVKKDG 360
>gb|AAF45368.1| (AE002611) CG9581 gene product [Drosophila melanogaster]
Length = 545
Score = 102 bits (252), Expect = 6e-21
Identities = 75/259 (28%), Positives = 130/259 (49%), Gaps = 41/259 (15%)
Query: 120 PLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELS 179
P + + MR+ K R+E++ M+ IA + F E+++ G SE L I+ + R +
Sbjct: 257 PAYTFLEAMRLLKSRDEMQLMRRTCDIASRSFNEVMAETRPGQSEHHLFAAIDYKCRMRN 316
Query: 180 DG-VSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRT-IAVGRPD 237
+++ P+VA+G+N+ H+ + + + D+V++D G + GY SDITRT A G
Sbjct: 317 ASYLAYPPVVAAGKNATVIHYVANSQLLGQQDLVLMDAGCEYGGYTSDITRTWPASGVFT 376
Query: 238 EKLIEVYEIVKEAQEKAYRAVRE-----------------GIKAKEVDKVA------REV 274
E +Y+++ + QE+ V + G +E+ V +E+
Sbjct: 377 EPQRTLYDMLHQLQEEIIGNVMKPGGETLDQLFETTCYKLGKYLQEIGLVGKSFSEYKEL 436
Query: 275 ISEAGYGEYFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYI---------- 324
+S+ GY + H H LG+DVH+ P++ + + GM FT+EPGIYI
Sbjct: 437 VSQ-GY-RFCPHHVSHYLGMDVHDTPHVPRNTRIV--PGMVFTVEPGIYIGQDCGDVPPE 492
Query: 325 -PGLGGVRIEDDVVVEGKG 342
G+ G+RIEDD+++ G
Sbjct: 493 FRGI-GIRIEDDLLINENG 510
>gb|AAD18095.1| (AC006416) Similar to gi|1573829 HI0816 aminopeptidase P homolog
(pepP) from Haemophilus influenzae genome gb|U32764.
[Arabidopsis thaliana]
Length = 451
Score = 101 bits (249), Expect = 1e-20
Identities = 72/257 (28%), Positives = 130/257 (50%), Gaps = 33/257 (12%)
Query: 121 LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL-S 179
LSSL +R+ K E++ M+ +A IA + + + E L+ ++E R +
Sbjct: 159 LSSLTHELRLIKSPAELKLMRESASIACQGLLKTMLHSKGFPDEGILSAQVEYECRVRGA 218
Query: 180 DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRT-IAVGRPDE 238
++F+P+V G N++ H+ +++I+ GD+V++D G GY SD+TRT G+
Sbjct: 219 QRMAFNPVVGGGSNASVIHYSRNDQRIKDGDLVLMDMGCELHGYVSDLTRTWPPCGKFSS 278
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVI-----------SEAGYGEYFTHR 287
E+Y+++ + ++ + + G ++++ + E++ S Y +
Sbjct: 279 VQEELYDLILQTNKECIKQCKPGTTIRQLNTYSTELLCDGLMKMGILKSRRLYHQLNPTS 338
Query: 288 TGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP----------GLGGVRIEDDVV 337
GH LG+DVH+ +G D L+ G TIEPG+YIP G+ G+RIEDDV+
Sbjct: 339 IGHYLGMDVHDSSAVGYDR--PLQPGFVITIEPGVYIPSSFDCPERFQGI-GIRIEDDVL 395
Query: 338 VEGKGKRLTKAGRELIT 354
+ T+ G E++T
Sbjct: 396 I-------TETGYEVLT 405
>sp|Q05813|AMP1_STRLI XAA-PRO AMINOPEPTIDASE I (X-PRO AMINOPEPTIDASE I) (AMINOPEPTIDASE P
I) (APP) (PEPP I) (AMINOACYLPROLINE AMINOPEPTIDASE I)
>gi|484336|pir||JN0491 X-Pro aminopeptidase (EC
3.4.11.9) - Streptomyces lividans
>gi|295167|gb|AAA26703.1| (M91546) peptidase P
[Streptomyces lividans]
Length = 491
Score = 98.7 bits (242), Expect = 9e-20
Identities = 82/262 (31%), Positives = 125/262 (47%), Gaps = 48/262 (18%)
Query: 129 RMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIE----VRIRELSDGVSF 184
R+ KD EI ++ A + FE+++ +L +E IE +R R + V +
Sbjct: 220 RLVKDEFEIGELQKAVDSTVRGFEDVVK--VLDRAEATSERYIEGTFFLRARVEGNDVGY 277
Query: 185 SPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRG-YCSDITRTIAV-GRPDEKLIE 242
I A+G ++ H + +R GD+++LD G Y +D+TRT+ + G E +
Sbjct: 278 GSICAAGPHACTLHWVRNDGPVRSGDLLLLDAGVETHTYYTADVTRTLPISGTYSELQKK 337
Query: 243 VYEIVKEAQEKAYRAVREGIKAKEVDKVAREVIS-----------------EAGYGEYFT 285
+Y+ V +AQE AVR G K ++ ++ V++ E G +T
Sbjct: 338 IYDAVYDAQEAGIAAVRPGAKYRDFHDASQRVLAERLVEWGLVEGPVERVLELGLQRRWT 397
Query: 286 -HRTGHGLGLDVHE------EPYIGPDGEVTLENGMTFTIEPGIYIP-----------GL 327
H TGH LG+DVH+ E Y+ DG TLE GM T+EPG+Y G+
Sbjct: 398 LHGTGHMLGMDVHDCAAARVESYV--DG--TLEPGMVLTVEPGLYFQADDLTVPEEYRGI 453
Query: 328 GGVRIEDDVVVEGKGKRLTKAG 349
GVRIEDD++V G R AG
Sbjct: 454 -GVRIEDDILVTADGNRNLSAG 474
>dbj|BAB05458.1| (AP001513) Xaa-Pro dipeptidase [Bacillus halodurans]
Length = 406
Score = 91.3 bits (223), Expect = 2e-17
Identities = 95/387 (24%), Positives = 174/387 (44%), Gaps = 48/387 (12%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
R++ K + + D +S SN+YYL+G ++V D + + + +
Sbjct: 10 RLNETKKRMMDEGIDVLLVSNPSNMYYLSGYSAWSFYVHQLLVVTLDDPQPLWIGREMDA 69
Query: 62 NVITNFPVTFWRDGE---------------NPYAKLSTILGELKLYRGRFLVEDTMRADW 106
+ + T W D + +P ++ IL E+ +G + M A +
Sbjct: 70 SSVVK---TTWLDEQQVIPYPDHYVQSETRHPMDFVTNILKEIG--QGNRTIGVEMDAHY 124
Query: 107 LIGILK------LGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL 160
G+ L N F ++LI +R+ K +EI+ M+ AA+IA+ + +
Sbjct: 125 FTGLCYQRLQQGLTNGTFKNATTLINWVRLIKSDQEIQVMRKAAKIAENAMKAAYDTVNV 184
Query: 161 GMSEKELALKIE-VRIRELS----DGVSFSPIVASGENSANPHHEPGERKIRKGDIVILD 215
G+ E ++A I +I+ + D S P++ +GEN++ PH +R ++GD + ++
Sbjct: 185 GVRECDVAAAISHAQIKGTAEFGGDYPSIVPMLPTGENTSCPHLTWTDRTYQEGDYLTVE 244
Query: 216 YGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVI 275
++ Y I RT+++G E + E+ ++V E + + +R G+ A+EV + I
Sbjct: 245 IAGCYKRYHVPIARTVSLGVAPEHVKELAKVVIEGIHETLQMIRPGVAAEEVAATWNQSI 304
Query: 276 SEAGYGEYFTHRTGHGLGL----DVHEEPYIGPDGEVT-LENGMTFTIEPGIYIPGLG-- 328
S+ G+ + R G+ +GL D E G+ T L+ MTF + PGI+ G
Sbjct: 305 SKHGFEK--NSRLGYSIGLSFPPDWGEHTVSLRQGDRTLLKPNMTFHLMPGIWYEDYGVE 362
Query: 329 ---GVRIEDDVVVEGKGKRLTKAGREL 352
+RI DD V + LT RE+
Sbjct: 363 ITESIRITDDGV-----ELLTNVSREI 384
>sp|Q60394|AMP2_STRLI XAA-PRO AMINOPEPTIDASE II (X-PRO AMINOPEPTIDASE II) (AMINOPEPTIDASE
P II) (APP) (PEPP II) (AMINOACYLPROLINE AMINOPEPTIDASE
II) >gi|487887|gb|AAB00325.1| (L23174) aminopeptidase P
[Streptomyces lividans] >gi|8977942|emb|CAB95809.1|
(AL359949) Xaa-Pro aminopeptidase II (EC 3.4.11.9)
[Streptomyces coelicolor A3(2)]
Length = 470
Score = 88.9 bits (217), Expect = 8e-17
Identities = 79/261 (30%), Positives = 118/261 (44%), Gaps = 44/261 (16%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSW--DILGMSEKELALKIEVRIRELSDGVSFS 185
+R+ KD E+ ++ A + F +++ + SE+ L R R + V +
Sbjct: 198 LRLVKDAWELGELRKAVDSTVRGFTDVVGELSRAVASSERWLEGTFFRRARLEGNAVGYG 257
Query: 186 PIVASGENSANPHHEPGERKIRKGDIVILDYGARWRG-YCSDITRTIAVGRPDEKL-IEV 243
I A+GE++ H + +R GD+++LD G R Y +D+TRT+ + L EV
Sbjct: 258 TICAAGEHATIMHWTDNDGPVRPGDLLLLDAGVETRSLYTADVTRTLPISGTFTPLQREV 317
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVIS-----------------EAGYGEYFTH 286
Y+ V EAQE V+ G ++ + A+ ++ E G FT
Sbjct: 318 YDAVYEAQEAGIATVKPGAAYRDFHEAAQRHLAARLVEWGFIEGPAERAYELGLQRRFTM 377
Query: 287 R-TGHGLGLDVHE------EPYIGPDGEVTLENGMTFTIEPGIYIP-----------GLG 328
TGH LGLDVH+ E Y+ E LE GM T+EPG+Y G+
Sbjct: 378 AGTGHMLGLDVHDCARARTEEYV----EGVLEPGMCLTVEPGLYFQADDLTVPEEWRGI- 432
Query: 329 GVRIEDDVVVEGKGKRLTKAG 349
GVRIEDD+VV G AG
Sbjct: 433 GVRIEDDLVVTEDGHENLSAG 453
>gi|10955071 agcA [Agrobacterium tumefaciens] >gi|2329863|emb|CAA80685.1|
(Z23166) catabolic mannopine cyclase [Agrobacterium
tumefaciens] >gi|8572699|gb|AAF77145.1| (AF242881) agcA
[Agrobacterium tumefaciens]
Length = 402
Score = 88.2 bits (215), Expect = 1e-16
Identities = 98/370 (26%), Positives = 153/370 (40%), Gaps = 30/370 (8%)
Query: 2 RIDRFVKLLNEMNFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLAPSLYS 61
RI+R + + D IS L + TGL VG RP LV+ G ++P +
Sbjct: 21 RIERAQAAMKSADVDVLAISGFDYLRFFTGLNGLPVG-RPIWLVLQKRGTASFVSPRSEA 79
Query: 62 NVITNFPVT----FWRDGENPYAKLSTILGELKLYRGRFLVEDT-----MRADWLIGI-- 110
I T W + E P + L Y + + W I
Sbjct: 80 KEIRARCATPVAAEWVEWEEPIPAPMSHQDALAKYIAEIAPDARTIGVDFNSTWASNIEL 139
Query: 111 --LKLGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELA 168
LG+ +S++R + K+ +E ++ A + + + + G +E ++
Sbjct: 140 VRQVLGHERIVDATSILRDLLALKNDAVVEGIRRATDVVAQQYAAARQAIVPGAAEWQVT 199
Query: 169 L-KIEVRIRELSDGVS-------FSP----IVASG-ENSANPHHEPGERKIRKGDIV-IL 214
L + I+ +D + F P +V SG E +A H G R + G+ V I
Sbjct: 200 LASLTAAIKRSADFLGEDVEQPRFWPHQMNMVGSGPERTARCHCSGGGRIMNDGEHVQIC 259
Query: 215 DYGARWRGYCSDITRTIAVGRPDE--KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAR 272
G + GY R I VG + +L +V ++AQE A ++ G A EV A
Sbjct: 260 LCGQVYCGYGICFDRPIPVGSKELPLELRKVVNFARQAQEAALARIKPGATAGEVHAAAV 319
Query: 273 EVISEAGYGEYFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRI 332
+VI G+ F HRTG G+G + + + V LE GM ++EPGIY+ G+GG R
Sbjct: 320 DVIESGGWDRPFLHRTGRGIGYSDWDGIELKANSPVRLEAGMVLSVEPGIYVDGVGGARF 379
Query: 333 EDDVVVEGKG 342
D V+V G
Sbjct: 380 GDTVLVTDTG 389
>pir||T32753 hypothetical protein W03G9.4 - Caenorhabditis elegans
>gi|2773225|gb|AAB96739.1| (AF039716) Similar to
aminopeptidase; coded for by C. elegans cDNA yk91g4.3;
coded for by C. elegans cDNA yk324c12.3; coded for by C.
elegans cDNA yk460e4.3; coded for by C. elegans cDNA
yk258c12.3; coded for by C. elegans cDNA yk285g6.3;
coded for by >
Length = 616
Score = 88.2 bits (215), Expect = 1e-16
Identities = 74/233 (31%), Positives = 115/233 (48%), Gaps = 23/233 (9%)
Query: 122 SSLIRLMRMRKDREEIENMKHAARIADKVFEEILSW---DILG---MSEKELALKIEVRI 175
+SL++ + K+ E++ M+++ E L W ++L +E ELA KI+ +
Sbjct: 308 TSLVQTAKATKNDHEMQGMRNSHLRDSAALVEFLCWLEKELLSGKRYTEIELADKID-HL 366
Query: 176 RELSDG---VSFSPIVASGENSANPHHEP----GERKIRKGDIVILDYGARWRGYCSDIT 228
R L D +SF I A G+++A PH++P G RK + +LD GA + +D+T
Sbjct: 367 RSLQDKYVTLSFDTISAVGDHAALPHYKPLGESGNRKAAANQVFLLDSGAHYGDGTTDVT 426
Query: 229 RTIAVGRPDEKLIEVYEIVKEAQEKAYRA-VREGIKAKEVDKVAREVISEAGYGEYFTHR 287
RT+ P ++ I +V + RA +GI +D + R+ + + G F H
Sbjct: 427 RTVWYTNPPKEFILHNTLVLKGHINLARAKFPDGIYGSRLDTLTRDALWKLGLD--FEHG 484
Query: 288 TGHGLG--LDVHEEPY-IGPDGEVT---LENGMTFTIEPGIYIPGLGGVRIED 334
TGHG+G L+VHE P IG T L TIEPG Y G+RIE+
Sbjct: 485 TGHGVGHYLNVHEGPIGIGHRSVPTGGELHASQVLTIEPGFYAKEKYGIRIEN 537
>emb|CAB62984.1| (AL035450) dJ1057D18.1 (novel protein similar to yeast and
bacterial PEPP (aminopeptidase P, aminoacylproline
aminopeptidase)) [Homo sapiens]
Length = 222
Score = 87.4 bits (213), Expect = 2e-16
Identities = 68/189 (35%), Positives = 92/189 (47%), Gaps = 32/189 (16%)
Query: 179 SDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPD 237
+D +++ P+VA G S H+ + I+ G++V+LD G Y SDITRT V GR
Sbjct: 10 ADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFT 69
Query: 238 EKLIEVYEIVKEAQ-------------EKAY----RAVREGIKAKEVDKVAREVISEAGY 280
E+YE V E Q E Y + + +K + K +E +
Sbjct: 70 APQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAA 129
Query: 281 GEYFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP-----------GLGG 329
+Y H GH LG+DVH+ P + + L+ GM TIEPGIYIP GL G
Sbjct: 130 RKYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGL-G 186
Query: 330 VRIEDDVVV 338
VRIEDDVVV
Sbjct: 187 VRIEDDVVV 195
>pir||D81414 probable aminopeptidase Cj0653c [imported] - Campylobacter jejuni
(strain NCTC 11168) >gi|6968120|emb|CAB75289.1|
(AL139075) putative aminopeptidase [Campylobacter
jejuni]
Length = 596
Score = 87.0 bits (212), Expect = 3e-16
Identities = 66/229 (28%), Positives = 116/229 (49%), Gaps = 35/229 (15%)
Query: 138 ENMKHAARIADKVFEE------ILSWDILGMSEKELALKIEVRIRE----------LSDG 181
+N K A I D + E+ +W + KEL ++++ ++ +SD
Sbjct: 297 KNTKEIAHIQDAMIEDGVALCKFFAWLEEAIKNKELISELDIDVKASEFRAQSKYYISD- 355
Query: 182 VSFSPIVASGENSANPHHEPGERK---IRKGDIVILDYGARWRGYCSDITRTIAVGRPDE 238
SF+ I EN+A PH++ + ++K ++++D G +++ +DITR + +G+ +
Sbjct: 356 -SFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTTDITRVVPIGKANA 414
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEY---FTHRTGHGLG-- 293
+ I Y +V KA+ A+ I K++ + I+ A + + H TGHG+G
Sbjct: 415 EQIHDYTLVL----KAHIAISSAIFPKDITMPLLDAITRAPLWKEQIDYIHGTGHGVGYF 470
Query: 294 LDVHEEP----YIGPDGEVT-LENGMTFTIEPGIYIPGLGGVRIEDDVV 337
L+VHE P Y+ P E T + GM +IEPGIY G G+R+E+ V+
Sbjct: 471 LNVHEGPQVLSYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLVI 519
>sp|P38487|CREA_BACSP CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|2126824|pir||I39809
creatinase (EC 3.5.3.3) - Bacillus sp
>gi|500611|dbj|BAA03358.1| (D14463) creatinase [Bacillus
sp.] >gi|1097201|prf||2113324A creatinase [Bacillus sp.]
Length = 411
Score = 85.8 bits (209), Expect = 7e-16
Identities = 87/307 (28%), Positives = 138/307 (44%), Gaps = 32/307 (10%)
Query: 66 NFPVTFWRDGENPYAKLSTILGELKLYRGRFLVE-DTMRADWLIGILK-LGNFEFHPLSS 123
N T W+ YA + +L E GR VE D M D + L N E +S
Sbjct: 100 NIVYTDWKRDNFLYA-VKKVLNEGGFSSGRLGVENDHMTLDLRRQVQDALPNTELVDVSQ 158
Query: 124 LIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALK-IEVRIRELSDGV 182
+ RM K EEI+ +K+ ARIAD ++ G+ E E+AL E +RE++
Sbjct: 159 AVMGHRMFKSDEEIDLIKNGARIADIGGAAVVEAIREGVPEYEVALHGTEAMVREIARTY 218
Query: 183 SFSPI------VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRP 236
+ + SG N+ H+ RK+++GDI+ L+ GY + + RT+ +
Sbjct: 219 PHAELRDTWIWFQSGINTDGAHNWATSRKLQRGDILSLNCFPMIAGYYTALERTLFLEEV 278
Query: 237 DEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISE--------AGYGEYF---T 285
++ +E++EI + + ++ G + ++ E+ E GYG F +
Sbjct: 279 SDRHLELWEINCKVHRRGLELIKPGARCMDIAAELNEIYREHDLLANRTFGYGHSFGVLS 338
Query: 286 HRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYI----PGLGGVRIEDDVVVEGK 341
H G GL++ E D E LE GM ++EP I I PG GG R D +V+
Sbjct: 339 HYYGREAGLELRE------DIETVLEPGMVVSMEPMIMIPEGEPGAGGYREHDILVISEN 392
Query: 342 G-KRLTK 347
G + +TK
Sbjct: 393 GTENITK 399
>sp|O51132|AMPM_BORBU METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435558|pir||A70113 methionine aminopeptidase (map)
homolog - Lyme disease spirochete
>gi|2687996|gb|AAC66499.1| (AE001123) methionine
aminopeptidase (map) [Borrelia burgdorferi]
Length = 251
Score = 85.0 bits (207), Expect = 1e-15
Identities = 59/206 (28%), Positives = 97/206 (46%), Gaps = 12/206 (5%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALK-----IEVRIRELSDGV-SFS 185
K ++EI+ +K +A + E+ + G+S KEL L I+ R + G F
Sbjct: 7 KSKDEIKKIKASASLLALTLLEVERNIVPGISTKELDLIAYDFIIKNRAKPAFKGYRGFK 66
Query: 186 PIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYE 245
+ + N H PG+RK+ GDIV +D G G+ SD+ +T VG D + ++ E
Sbjct: 67 GTICASVNEEVIHGIPGKRKLADGDIVSIDCGVILDGFYSDMAKTFKVGNVDSSIDKLLE 126
Query: 246 IVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP----Y 301
+ + K ++ G + + K + I G+G TGHG+G ++HEEP Y
Sbjct: 127 VTNASLYKGIAEMKVGNRILNISKAIEDYIKPFGFG-IVREYTGHGVGFELHEEPSVPNY 185
Query: 302 IGP-DGEVTLENGMTFTIEPGIYIPG 326
P + ++ GM IEP + + G
Sbjct: 186 YAPFFKNIRIQEGMVLAIEPMVNLRG 211
>pir||S69353 aminopeptidase P - pig >gi|994862|gb|AAB34314.1| aminopeptidase P,
AP-P [swine, kidney cortex, Peptide, 624 aa]
Length = 624
Score = 84.3 bits (205), Expect = 2e-15
Identities = 62/174 (35%), Positives = 87/174 (49%), Gaps = 9/174 (5%)
Query: 177 ELSDGVSFSPIVASGENSANPHHEPGE---RKIRKGDIVILDYGARWRGYCSDITRTIAV 233
E G SF I ASG N+A H+ P + RK+ ++ +LD G ++ +DITRT+
Sbjct: 382 EFFSGPSFETISASGLNAALAHYSPTKELHRKLSSDEMYLLDSGGQYWDGTTDITRTVHW 441
Query: 234 GRPDEKLIEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEAGYGEYFTHRTGHGL 292
G P E Y V R V + V+ AR+ + + G + H TGHG+
Sbjct: 442 GTPSAFQKEAYTRVLIGNIDLSRLVFPAATSGRVVEAFARKALWDVGLN--YGHGTGHGI 499
Query: 293 G--LDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIED-DVVVEGKGK 343
G L+VHE P G + + GM +IEPG Y G G+R+ED +VVE K K
Sbjct: 500 GNFLEVHEWPVGFQYGNIPMAEGMFTSIEPGYYQDGEFGIRLEDVALVVEAKTK 553
>pir||T47008 hypothetical protein [imported] - Yersinia pestis
>gi|4106596|emb|CAA21351.1| (AL031866) ORF28, len: 405
aa, similar to a proline peptidase protein in Bacillus
subtilis O31689, Fasta scores opt: 354, E(): 2.6e-15,
25.7% identity in 284 aa overlap, and Streptococcus
lactis O08316, Fasta scores: opt: 332, E(): 6.3e-14,
25.9% i>
Length = 405
Score = 84.3 bits (205), Expect = 2e-15
Identities = 61/236 (25%), Positives = 108/236 (44%), Gaps = 7/236 (2%)
Query: 122 SSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDG 181
++L +RM K EIE+++ +A I + +G + EL + + +
Sbjct: 168 TALFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPE- 226
Query: 182 VSFSP--IVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEK 239
+FS +++ G+N + P + GD++ D G GY +D+ RT +G PD+
Sbjct: 227 TNFSRFNLISVGDNFS-PKIIADTTPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKL 285
Query: 240 LIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLG--LDVH 297
++Y+ ++ E V G+K K V VI +G Y GHG G L +
Sbjct: 286 TQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGLPHYNRGHLGHGDGVFLGLE 345
Query: 298 EEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG-KRLTKAGREL 352
E P++ T GM ++E Y G+G + +ED +++ G + L+K R+L
Sbjct: 346 EVPFVSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILITDSGFEFLSKLDRDL 401
>sp|P27875|AGS_AGRRH AGROPINE SYNTHESIS CYCLASE >gi|77884|pir||JQ1051 agropine synthase
- Agrobacterium rhizogenes plasmid Ri
>gi|407085|emb|CAA35719.1| (X51338) cyclase
[Agrobacterium rhizogenes]
Length = 396
Score = 83.9 bits (204), Expect = 3e-15
Identities = 53/160 (33%), Positives = 81/160 (50%), Gaps = 4/160 (2%)
Query: 187 IVASG-ENSANPHHEPGERKIRKGDIV-ILDYGARWRGYCSDITRTIAVGRPD--EKLIE 242
+V SG + +A H G R ++ G I I G +RG+ + R + +G L +
Sbjct: 224 MVGSGADRTARCHPSGGGRIMQDGAIAQICLCGQTFRGHAACFDRPVPIGSKPLPANLRK 283
Query: 243 VYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI 302
V ++ +EAQ A A+R G+ A E+ A VI +G+ F HRTG G+G + +
Sbjct: 284 VIDVAREAQSAALAALRPGVTAGEIHAAAVAVIKRSGWEAPFLHRTGRGIGYSDWDGIEL 343
Query: 303 GPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKG 342
+ LE G +IEPG+Y+ G+GG R D V+V G
Sbjct: 344 KAGSQTVLEVGNVLSIEPGVYVQGIGGARFGDTVLVSETG 383
>sp|Q10439|YDE5_SCHPO PROBABLE 55.1 KDA PEPTIDASE C12B10.05 >gi|7492718|pir||T37572
probable metalloproteinase - fission yeast
(Schizosaccharomyces pombe) >gi|4008582|emb|CAA94695.1|
(Z70721) putative metallopeptidase [Schizosaccharomyces
pombe]
Length = 486
Score = 83.9 bits (204), Expect = 3e-15
Identities = 68/245 (27%), Positives = 110/245 (44%), Gaps = 33/245 (13%)
Query: 121 LSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSD 180
+ L+ +R K E+E MK AA I+ V+ EI+ EKE + E R
Sbjct: 224 VDELLHPLRSIKSTAELECMKEAANISSNVYREIMRKRF----EKEAEMSAEFNYRFCIG 279
Query: 181 GV---SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRP 236
G ++ P+VA G+N H+ R ++V++D G + GY +DI+RT + G+
Sbjct: 280 GCDRSAYVPVVAGGKNGLTIHYTINNDIFRPDEMVLVDAGGEFGGYVTDISRTWPINGKF 339
Query: 237 DEKLIEVYEIVKEAQEKA--YRAVREGIKAKEVD----KVAREVISEAG-YGE------- 282
++Y+ V Q+K Y G ++ K+ E + + G +G
Sbjct: 340 STVQRDLYQAVLNVQKKCIKYCCTSNGWSLADIHFESVKLMHEELKQVGIHGTKREITDI 399
Query: 283 YFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGG---------VRIE 333
+ H GH +GL++H+ +G L TIEPG+Y+P G +RIE
Sbjct: 400 LYPHSIGHEIGLEIHD--CSTNNGYQPLRKNQVITIEPGLYVPEEDGWPQWAQGIAIRIE 457
Query: 334 DDVVV 338
D V+V
Sbjct: 458 DSVIV 462
>emb|CAA19220.1| (AL023653) dJ753P9.1 (Aminopeptidase P (EC 3.4.11.9,
XAA-Pro/X-Pro/Proline/Aminoacylproline Aminopeptidase))
[Homo sapiens] >gi|11066157|gb|AAG28480.1| (AF195953)
membrane-bound aminopeptidase P [Homo sapiens]
Length = 674
Score = 83.5 bits (203), Expect = 3e-15
Identities = 61/174 (35%), Positives = 86/174 (49%), Gaps = 9/174 (5%)
Query: 177 ELSDGVSFSPIVASGENSANPHHEPGE---RKIRKGDIVILDYGARWRGYCSDITRTIAV 233
+ S G SF I ASG N+A H+ P + RK+ ++ +LD G ++ +DITRT+
Sbjct: 409 QFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHW 468
Query: 234 GRPDEKLIEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEAGYGEYFTHRTGHGL 292
G P E Y V R + + V+ AR + +AG + H TGHG+
Sbjct: 469 GTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLN--YGHGTGHGI 526
Query: 293 G--LDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIED-DVVVEGKGK 343
G L VHE P + + GM +IEPG Y G G+R+ED +VVE K K
Sbjct: 527 GNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTK 580
>gi|10880126 X-prolyl aminopeptidase 2, membrane-bound; aminoacylproline
aminopeptidase; aminopeptidase P; X-prolyl
aminopeptidase 2 (aminopeptidase P) [Homo sapiens]
>gi|10190809|gb|AAB96394.2| (U90724) aminopeptidase P
[Homo sapiens]
Length = 674
Score = 83.5 bits (203), Expect = 3e-15
Identities = 61/174 (35%), Positives = 86/174 (49%), Gaps = 9/174 (5%)
Query: 177 ELSDGVSFSPIVASGENSANPHHEPGE---RKIRKGDIVILDYGARWRGYCSDITRTIAV 233
+ S G SF I ASG N+A H+ P + RK+ ++ +LD G ++ +DITRT+
Sbjct: 409 QFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHW 468
Query: 234 GRPDEKLIEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEAGYGEYFTHRTGHGL 292
G P E Y V R + + V+ AR + +AG + H TGHG+
Sbjct: 469 GTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLN--YGHGTGHGI 526
Query: 293 G--LDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIED-DVVVEGKGK 343
G L VHE P + + GM +IEPG Y G G+R+ED +VVE K K
Sbjct: 527 GNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTK 580
>gi|6320922 Yer078cp [Saccharomyces cerevisiae] >gi|731481|sp|P40051|YEQ8_YEAST
HYPOTHETICAL 58.0 KD PEPTIDASE IN PTP3-ILV1 INTERGENIC
REGION >gi|1077673|pir||S50581 hypothetical protein
YER078c - yeast (Saccharomyces cerevisiae)
>gi|603316|gb|AAB64633.1| (U18839) Yer078cp
[Saccharomyces cerevisiae]
Length = 511
Score = 83.1 bits (202), Expect = 5e-15
Identities = 69/258 (26%), Positives = 114/258 (43%), Gaps = 43/258 (16%)
Query: 113 LGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIE 172
+ N P+S I R K +E+ M+ A +I+ + F + + E L
Sbjct: 226 IANKTIKPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAFAKRF----RNERTLDSF 281
Query: 173 VRIRELSDGV---SFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITR 229
+ + +S G ++ P+VA+G NS H+ + + ++V++D GYC+DI+R
Sbjct: 282 LHYKFISGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISR 341
Query: 230 TIA-VGRPDEKLIEVYEIVKEAQ-------------------EKAYRAVREGIKAKEVDK 269
T G+ + ++YE V Q EK+ +++ +K +DK
Sbjct: 342 TWPNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDK 401
Query: 270 VAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLG- 328
V S + + H GH LGLDVH+ P + L+ G TIEPG+YIP
Sbjct: 402 V-----SGWNVEKLYPHYIGHNLGLDVHDVPKV--SRYEPLKVGQVITIEPGLYIPNEES 454
Query: 329 --------GVRIEDDVVV 338
G+RIEDD+ +
Sbjct: 455 FPSYFRNVGIRIEDDIAI 472
>gi|10955029 ags [Agrobacterium tumefaciens] >gi|8572686|gb|AAF77132.1|
(AF242881) ags [Agrobacterium tumefaciens]
Length = 395
Score = 83.1 bits (202), Expect = 5e-15
Identities = 55/172 (31%), Positives = 88/172 (50%), Gaps = 11/172 (6%)
Query: 187 IVASGEN-SANPHHEPGERKIRKGDIV-ILDYGARWRGYCSDITRTIAVGRP--DEKLIE 242
+V SG N +A H G R ++ G+ V + G +RG+ R + VG +++
Sbjct: 223 MVGSGANRTARCHTSGGGRIMQDGEHVQVCLCGQLFRGHAVRFDRPLPVGSKPLSGDILK 282
Query: 243 VYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI 302
V + ++AQ A A+R G+ A+EV A V++ G+ + F HRTG G+G + +
Sbjct: 283 VIKTARDAQLAALSAIRPGVMAREVHAAAVAVVNRGGWTDPFLHRTGRGIGYSDWDGIEL 342
Query: 303 GPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELIT 354
E L+ G ++EPGIY+ G+GG R D V+V T+ G E +T
Sbjct: 343 KAGAETMLKVGNVLSVEPGIYVEGIGGARFGDTVLV-------TETGYEALT 387
>gi|11420265 X-prolyl aminopeptidase 2, membrane-bound [Homo sapiens]
Length = 674
Score = 83.1 bits (202), Expect = 5e-15
Identities = 61/174 (35%), Positives = 86/174 (49%), Gaps = 9/174 (5%)
Query: 177 ELSDGVSFSPIVASGENSANPHHEPGE---RKIRKGDIVILDYGARWRGYCSDITRTIAV 233
+ S G SF I ASG N+A H+ P + RK+ ++ +LD G ++ +DITRT+
Sbjct: 409 QFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHW 468
Query: 234 GRPDEKLIEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEAGYGEYFTHRTGHGL 292
G P E Y V R + + V+ AR + +AG + H TGHG+
Sbjct: 469 GTPSAFHQEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLN--YGHGTGHGI 526
Query: 293 G--LDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIED-DVVVEGKGK 343
G L VHE P + + GM +IEPG Y G G+R+ED +VVE K K
Sbjct: 527 GNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTK 580
>pir||S72440 X-Pro aminopeptidase (EC 3.4.11.9) precursor - pig
>gi|1517942|gb|AAC48664.1| (U55039) aminopeptidase P
[Sus scrofa]
Length = 673
Score = 82.3 bits (200), Expect = 8e-15
Identities = 62/174 (35%), Positives = 86/174 (48%), Gaps = 9/174 (5%)
Query: 177 ELSDGVSFSPIVASGENSANPHHEPGE---RKIRKGDIVILDYGARWRGYCSDITRTIAV 233
E G SF I ASG N+A H+ P + RK+ ++ +LD G ++ +DITRT+
Sbjct: 408 EFFSGPSFETISASGLNAALAHYSPTKELHRKLSSDEMYLLDSGGQYWDGTTDITRTVHW 467
Query: 234 GRPDEKLIEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEAGYGEYFTHRTGHGL 292
G P E Y V R V + V+ AR+ + + G + H TGHG+
Sbjct: 468 GTPSAFQKEAYTRVLIGNIDLSRLVFPAATSGRVVEAFARKALWDVGLN--YGHGTGHGI 525
Query: 293 G--LDVHEEPYIGPDGEVTLENGMTFTIEPGIYIPGLGGVRIED-DVVVEGKGK 343
G L VHE P G + + GM +IEPG Y G G+R+ED +VVE K K
Sbjct: 526 GNFLCVHEWPVGFQYGNIPMAEGMFTSIEPGYYQDGEFGIRLEDVALVVEAKTK 579
>gi|6321118 Yfr006wp [Saccharomyces cerevisiae]
>gi|1175977|sp|P43590|YFH6_YEAST HYPOTHETICAL 61.8 KD
PEPTIDASE IN MPR1-GCN20 INTERGENIC REGION
>gi|1084731|pir||S56261 probable membrane protein
YFR006w - yeast (Saccharomyces cerevisiae)
>gi|836761|dbj|BAA09245.1| (D50617) YFR006W
[Saccharomyces cerevisiae]
Length = 535
Score = 81.9 bits (199), Expect = 1e-14
Identities = 77/286 (26%), Positives = 118/286 (40%), Gaps = 67/286 (23%)
Query: 129 RMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRI-RELSDGVSFSPI 187
R KD EIE+++ A +I+DK ++S + ++E ++ + E R+ + + PI
Sbjct: 229 RAIKDWYEIESIRKACQISDKSHLAVMSALPIELNELQIQAEFEYHATRQGGRSLGYDPI 288
Query: 188 VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAV-GRPDEKLIEVYEI 246
SG H+ I+ +++D GA WR Y SDITR G+ + EVYE
Sbjct: 289 CCSGPACGTLHYVKNSEDIKGKHSILIDAGAEWRQYTSDITRCFPTSGKFTAEHREVYET 348
Query: 247 VKEAQEKAYRAVREGIKAKEVDKVAREV---------ISEAGYGE-----------YFTH 286
V + Q +A ++ G K ++ + +V I + + E ++ H
Sbjct: 349 VLDMQNQAMERIKPGAKWDDLHALTHKVLIKHFLSMGIFKKEFSEDEIFKRRASCAFYPH 408
Query: 287 RTGHGLGLDVHE----EPYIGPDG-------EVTLENGMTFTIEPGIYIPG--------- 326
GH LGLDVH+ Y PD L+ M T EPG Y
Sbjct: 409 GLGHMLGLDVHDVGGNPNYDDPDPMFRYLRIRRPLKENMVITNEPGCYFNQFLIKEFLEK 468
Query: 327 ------------------LGGVRIEDDVVVEGKGKRLTKAGRELIT 354
+GGVRIEDD++V TK G E +T
Sbjct: 469 HPERLEVVDMSVLKRYMYVGGVRIEDDILV-------TKDGYENLT 507
>pir||F72247 methionine aminopeptidase - Thermotoga maritima (strain MSB8)
>gi|4982042|gb|AAD36544.1|AE001798_9 (AE001798)
methionine aminopeptidase [Thermotoga maritima]
Length = 250
Score = 81.9 bits (199), Expect = 1e-14
Identities = 61/207 (29%), Positives = 95/207 (45%), Gaps = 26/207 (12%)
Query: 132 KDREEIENMKHAARIADKVFEEI--------LSWDILGMSEKELALKIEVRIRELS---- 179
K EIE MK A + E+ +WD+ + L L+I ++R
Sbjct: 5 KTPSEIEKMKKAGKAVAVALREVRKVIVPGKTAWDV-----ETLVLEIFKKLRVKPAFKG 59
Query: 180 -DGVSFSPIVASGENSANPHHEPGERKI-RKGDIVILDYGARWRGYCSDITRTIAVGRPD 237
G ++ V+ E H P + K+ ++GDIV +D GA ++G D T VG D
Sbjct: 60 YGGYKYATCVSVNEEVV--HGLPLKEKVFKEGDIVSVDVGAVYQGLYGDAAVTYIVGETD 117
Query: 238 EKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVH 297
E+ E+ + +E EKA + ++ GI+ +V +E + G+ GHG+G ++H
Sbjct: 118 ERGKELVRVTREVLEKAIKMIKPGIRLGDVSHCIQETVESVGF-NVIRDYVGHGVGRELH 176
Query: 298 EEP----YIGPDGEVTLENGMTFTIEP 320
E+P Y P V L GMT IEP
Sbjct: 177 EDPQIPNYGTPGTGVVLRKGMTLAIEP 203
>pir||T44250 creatinase (EC 3.5.3.3) [validated] - Arthrobacter sp. (strain
TE1826) >gi|3116223|dbj|BAA25928.1| (AB007122)
creatinase [Arthrobacter sp.]
Length = 411
Score = 80.8 bits (196), Expect = 2e-14
Identities = 81/301 (26%), Positives = 134/301 (43%), Gaps = 31/301 (10%)
Query: 66 NFPVTFWRDGENPYAKLSTILGELKLYRGRF-LVEDTMRADWLIGILK-LGNFEFHPLSS 123
N T WR +N + + +L E + + R + ED + D L NFE +S
Sbjct: 99 NIVYTDWRR-DNYFYAIQKVLEEAGVKKARLGIEEDHVSIDLLRKFSDTFPNFELVHVSQ 157
Query: 124 LIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALK-IEVRIRELSDGV 182
+ RM K EEI ++K+ ARIAD ++ G+ E E+AL + RE++
Sbjct: 158 DVMKQRMIKSAEEIRHIKNGARIADIGGYAVVEAIQEGVPEYEVALAGSKAMTREIAKLY 217
Query: 183 SFSPI------VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRP 236
S + +G N+ H +K++KG+I+ L+ GY + + RT+ +
Sbjct: 218 PQSELRDTWVWFQAGINTDGAHSWATSKKVQKGEILSLNTFPMIAGYYTALERTLFLEEV 277
Query: 237 DEKLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISE--------AGYGEYF---T 285
+ ++ +EI E ++ ++ G K++ E+ E GYG F +
Sbjct: 278 SDAHLKYWEINVEVHKRGLELIKPGAVCKDICAELNEMFREHDLVKNRTFGYGHSFGVLS 337
Query: 286 HRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYI----PGLGGVRIEDDVVVEGK 341
H G GL++ E D + LE GM ++EP I I PG GG R D +V++
Sbjct: 338 HYYGREAGLELRE------DIDTILEPGMVISMEPMILIPEGQPGAGGYREHDILVIQEN 391
Query: 342 G 342
G
Sbjct: 392 G 392
>gb|AAF53589.1| (AE003653) ApepP gene product [Drosophila melanogaster]
Length = 613
Score = 80.8 bits (196), Expect = 2e-14
Identities = 59/169 (34%), Positives = 89/169 (51%), Gaps = 14/169 (8%)
Query: 181 GVSFSPIVASGENSANPHHEPGE---RKIRKGDIVILDYGARWRGYCSDITRTIAVGRPD 237
G+SF+ I ASG N + H+ P + RKI +I + D GA++ +D+TRT+ G P
Sbjct: 371 GLSFTTISASGPNGSVIHYHPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHFGEPT 430
Query: 238 EKLIEVYEIVKEAQEKAYRAVREG-IKAKEVDKVAREVISEAGYGEYFTHRTGHGLG--L 294
E E Y V + Q V +K + +D +AR+ + + G + H TGHG+G L
Sbjct: 431 EFQKEAYTRVLKGQLSFGSTVFPAKVKGQVLDTLARKALWDVGLD--YGHGTGHGVGHFL 488
Query: 295 DVHEEPY-----IGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV 338
+VHE P + PD + L+ M + EPG Y G G+R+ED V +
Sbjct: 489 NVHEGPMGVGIRLMPD-DPGLQANMFISNEPGFYQDGEFGIRVEDIVQI 536
>sp|Q9Z9J4|AMPM_BACHD METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|11264635|pir||T44405 methionyl aminopeptidase (EC
3.4.11.18) map [imported] - Bacillus halodurans
>gi|4512426|dbj|BAA75293.1| (AB017508) map homologue
(identity of 81% to B. subtilis ) [Bacillus halodurans]
>gi|10172768|dbj|BAB03875.1| (AP001507) methionine
aminopeptidase [Bacillus halodurans]
Length = 248
Score = 80.4 bits (195), Expect = 3e-14
Identities = 68/244 (27%), Positives = 108/244 (43%), Gaps = 23/244 (9%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPI---- 187
K E+E M+ A RI +EI G++ K+L E IR SF
Sbjct: 5 KTERELEIMREAGRIVALTHQEIKLHIQPGITTKKLDEIAETFIRSHGATPSFKGYNGFT 64
Query: 188 --VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYE 245
+ + N H PG R +++GDI+ +D GA++ GY D T AVG ++ ++ +
Sbjct: 65 GSICASVNEELVHGIPGNRVLKEGDIISVDIGAKYNGYHGDSAWTYAVGNISDEDQDLLD 124
Query: 246 IVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI--- 302
+ + + K + G + ++ + GY GHG+G ++HE+P I
Sbjct: 125 VTETSLYKGLEQAKAGARLSDISHAIQSYAEPRGYA-IVREYVGHGVGQNLHEDPQIPHY 183
Query: 303 GPDGE-VTLENGMTFTIEPGIYIPGLGGVRIEDD--VVVEGKGKR---------LTKAGR 350
GP G+ L+ GM IEP + G VR D VV GK+ +T+ G
Sbjct: 184 GPPGKGPRLKPGMVLAIEPMVN-AGSRYVRTLSDNWTVVTVDGKKCAHFEHTIAITETGY 242
Query: 351 ELIT 354
E++T
Sbjct: 243 EILT 246
>pir||E71651 hypothetical protein RP482 - Rickettsia prowazekii
>gi|3861035|emb|CAA14935.1| (AJ235272) unknown
[Rickettsia prowazekii]
Length = 591
Score = 80.0 bits (194), Expect = 4e-14
Identities = 64/189 (33%), Positives = 98/189 (50%), Gaps = 14/189 (7%)
Query: 162 MSEKELALKIEVRIRELSDGV---SFSPIVASGENSANPHHEPGER---KIRKGDIVILD 215
++E L LK+ + R +G SF I ENSA H+ + KI I+++D
Sbjct: 337 ITEHSLCLKLTAQ-RAKQEGYVSDSFHAICGFQENSAIIHYRANPKTAKKIEGHGILLID 395
Query: 216 YGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRA--VREGIKAKEVDKVARE 273
GA+++G +DITRTI VG P + + Y V + RA + + +D +AR+
Sbjct: 396 SGAQYKGATTDITRTIIVGIPTCEQKKRYTQVLKGHIALTRAKFPKNIVTGANLDILARQ 455
Query: 274 VISEAGYGEYFTHRTGHGLG--LDVHEEPY-IGPDGEVTLENGMTFTIEPGIYIPGLGGV 330
+ + + H TGHG+G L VHE P I ++ L+ GM + EPG YIPG G+
Sbjct: 456 YLWQDMID--YPHGTGHGVGSFLSVHEGPQSINLSNKIILKAGMILSNEPGFYIPGKYGI 513
Query: 331 RIEDDVVVE 339
RIE+ + V+
Sbjct: 514 RIENLIYVK 522
>pir||E81084 aminopeptidase, probable NMB1428 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226668|gb|AAF41789.1| (AE002492) aminopeptidase,
putative [Neisseria meningitidis MC58]
Length = 598
Score = 78.8 bits (191), Expect = 9e-14
Identities = 82/281 (29%), Positives = 128/281 (45%), Gaps = 35/281 (12%)
Query: 78 PYA----KLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHPLSSLIRLMRMRKD 133
PYA KL+ I G L + + V +R + +++ N S+L + + D
Sbjct: 250 PYAQVADKLAQIGGVLLIEPNKTAVSTLVRLPESVRLIEGIN-----PSTLFKSCKSEAD 304
Query: 134 REEI-ENMKHAARIADKVFEEILSWDILGMSEKELALKIEV---RIRELSDG---VSFSP 186
I E M+H F E DI+G + ++ R R + G +SF
Sbjct: 305 IARIREAMEHDGAALCGFFAEFE--DIIGNGGSLTEIDVDTMLYRHRSVRPGFISLSFDT 362
Query: 187 IVASGENSANPHHEP---GERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
I N A PH+ I ++++D GA+++G +DITR + VG P +
Sbjct: 363 IAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGGTTDITRVVPVGTPSAEQKSD 422
Query: 244 YEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEA--GYGEYFTHRTGHGLG--LDVHE 298
+V +A AV E I + +D + R+ + +A YG H TGHG+G L+VHE
Sbjct: 423 NTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDYG----HGTGHGVGYFLNVHE 478
Query: 299 EP----YIGP-DGEVTLENGMTFTIEPGIYIPGLGGVRIED 334
P + P E ++ GM +IEPG+Y PG G+RIE+
Sbjct: 479 GPQRIAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIEN 519
>pir||D81858 probable aminopeptidase NMA1640 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7380282|emb|CAB84868.1|
(AL162756) putative aminopeptidase [Neisseria
meningitidis Z2491]
Length = 659
Score = 78.8 bits (191), Expect = 9e-14
Identities = 82/281 (29%), Positives = 128/281 (45%), Gaps = 35/281 (12%)
Query: 78 PYA----KLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHPLSSLIRLMRMRKD 133
PYA KL+ I G L + + V +R + +++ N S+L + + D
Sbjct: 311 PYAQVADKLAQIGGALLIEPNKTAVSTLVRLPESVRLIEGIN-----PSTLFKSCKSEAD 365
Query: 134 REEI-ENMKHAARIADKVFEEILSWDILGMSEKELALKIEV---RIRELSDG---VSFSP 186
I E M+H F E DI+G + ++ R R + G +SF
Sbjct: 366 IARIREAMEHDGAALCGFFAEFE--DIIGNGGSLTEIDVDTMLYRHRSVRPGFISLSFDT 423
Query: 187 IVASGENSANPHHEP---GERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
I N A PH+ I ++++D GA+++G +DITR + VG P +
Sbjct: 424 IAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGGTTDITRVVPVGTPTAEQKRD 483
Query: 244 YEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEA--GYGEYFTHRTGHGLG--LDVHE 298
+V +A AV E I + +D + R+ + +A YG H TGHG+G L+VHE
Sbjct: 484 NTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDYG----HGTGHGVGYFLNVHE 539
Query: 299 EP----YIGP-DGEVTLENGMTFTIEPGIYIPGLGGVRIED 334
P + P E ++ GM +IEPG+Y PG G+RIE+
Sbjct: 540 GPQRIAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIEN 580
>gb|AAF75795.1|AF272981_1 (AF272981) cytosolic aminopeptidase P [Homo sapiens]
Length = 623
Score = 78.8 bits (191), Expect = 9e-14
Identities = 75/228 (32%), Positives = 110/228 (47%), Gaps = 28/228 (12%)
Query: 132 KDREEIENMKHAARIADKV-FEEILSW-----DILGMSEKELALKIEVRIRELSDGV--S 183
K+ E E M+ A I D V E+ +W G++E A K E R+ +D V S
Sbjct: 322 KNSAESEGMRRA-HIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLS 380
Query: 184 FSPIVASGENSANPHHEP---GERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
F I ++G N A H+ P R + ++ ++D GA+++ +D+TRT+ G P
Sbjct: 381 FPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYE 440
Query: 241 IEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLG--LDVH 297
E + V + AV G K +D AR + ++G + H TGHG+G L+VH
Sbjct: 441 KECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLD--YLHGTGHGVGSFLNVH 498
Query: 298 EEPYIGPDG-------EVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV 338
E GP G + LE GM T EPG Y G G+RIE+ V+V
Sbjct: 499 E----GPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLV 542
>gi|5730118 X-prolyl aminopeptidase (aminopeptidase P)-like; pepP [Homo
sapiens] >gi|2584787|emb|CAA65068.1| (X95762)
Aminopeptidase P-like [Homo sapiens]
>gi|9739017|gb|AAF97866.1|AF195530_1 (AF195530) soluble
aminopeptidase P [Homo sapiens]
Length = 623
Score = 78.4 bits (190), Expect = 1e-13
Identities = 75/228 (32%), Positives = 110/228 (47%), Gaps = 28/228 (12%)
Query: 132 KDREEIENMKHAARIADKV-FEEILSW-----DILGMSEKELALKIEVRIRELSDGV--S 183
K+ E E M+ A I D V E+ +W G++E A K E R+ +D V S
Sbjct: 322 KNSAESEGMR-PAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLS 380
Query: 184 FSPIVASGENSANPHHEP---GERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
F I ++G N A H+ P R + ++ ++D GA+++ +D+TRT+ G P
Sbjct: 381 FPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYE 440
Query: 241 IEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLG--LDVH 297
E + V + AV G K +D AR + ++G + H TGHG+G L+VH
Sbjct: 441 KECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLD--YLHGTGHGVGSFLNVH 498
Query: 298 EEPYIGPDG-------EVTLENGMTFTIEPGIYIPGLGGVRIEDDVVV 338
E GP G + LE GM T EPG Y G G+RIE+ V+V
Sbjct: 499 E----GPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLV 542
>emb|CAA10526.1| (AJ131920) aminopeptidase P [Drosophila melanogaster]
Length = 613
Score = 78.4 bits (190), Expect = 1e-13
Identities = 57/167 (34%), Positives = 88/167 (52%), Gaps = 14/167 (8%)
Query: 181 GVSFSPIVASGENSANPHHEPGE---RKIRKGDIVILDYGARWRGYCSDITRTIAVGRPD 237
G+SF+ + ASG N + H+ P + RKI ++ + D GA++ +D+TRT+ G P
Sbjct: 371 GLSFTTMSASGPNGSVMHYHPKKETNRKINDKEMYLCDSGAQYLDGTTDVTRTLHFGEPT 430
Query: 238 EKLIEVYEIVKEAQEKAYRAVREG-IKAKEVDKVAREVISEAGYGEYFTHRTGHGLG--L 294
E E Y V + Q V +K + +D +AR+ + + G + H TGHG+G L
Sbjct: 431 EFQKEAYTRVLKGQLSFGSTVFPAKVKGQVLDTLARKALWDVGLD--YGHGTGHGVGHFL 488
Query: 295 DVHEEPY-----IGPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDDV 336
+VHE P + PD + L+ M + EPG Y G G+R+ED V
Sbjct: 489 NVHEGPMGVGMRLMPD-DPGLQANMFMSNEPGFYQDGEFGIRVEDMV 534
>gb|AAB95331.1| (AF038591) cytoplasmic aminopeptidase P [Rattus norvegicus]
Length = 623
Score = 78.0 bits (189), Expect = 2e-13
Identities = 65/193 (33%), Positives = 96/193 (49%), Gaps = 21/193 (10%)
Query: 161 GMSEKELALKIEVRIRELSDGV--SFSPIVASGENSANPHHEP---GERKIRKGDIVILD 215
G++E A K E R+ +D V SF I ++G N A H+ P R + ++ ++D
Sbjct: 356 GVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPIPETNRTLSLDEVYLID 415
Query: 216 YGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRAV-REGIKAKEVDKVAREV 274
GA+++ +D+TRT+ G P E + V + AV G K +D AR
Sbjct: 416 SGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSA 475
Query: 275 ISEAGYGEYFTHRTGHGLG--LDVHEEPYIGPDG-------EVTLENGMTFTIEPGIYIP 325
+ ++G + H TGHG+G L+VHE GP G + LE GM T EPG Y
Sbjct: 476 LWDSGLD--YLHGTGHGVGSFLNVHE----GPCGISYKTFSDEPLEAGMIVTDEPGYYED 529
Query: 326 GLGGVRIEDDVVV 338
G G+RIE+ V+V
Sbjct: 530 GAFGIRIENVVLV 542
>pir||C75410 methionine aminopeptidase - Deinococcus radiodurans (strain R1)
>gi|6459062|gb|AAF10883.1|AE001978_3 (AE001978)
methionine aminopeptidase [Deinococcus radiodurans]
Length = 259
Score = 78.0 bits (189), Expect = 2e-13
Identities = 59/205 (28%), Positives = 92/205 (44%), Gaps = 15/205 (7%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRE-------LSDGVSF 184
K EIE M+ A + + F + + G++ KEL + E IR L G
Sbjct: 13 KSAREIETMRRAGGLVAETFRVLEPYVQPGVTLKELDRRAEEFIRGKGAKPAYLGYGPRN 72
Query: 185 SPI---VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLI 241
+P + + N H P +R++R GDI+ +D G GY D T VG+ +++
Sbjct: 73 NPFPGTICASVNEVICHGIPDDRELRDGDILGMDIGVLLDGYYGDACTTYTVGQVSDEVR 132
Query: 242 EVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPY 301
+ + + + VR G K ++ + + GYG TGHG+G +HE+P
Sbjct: 133 ALVDTTRACLQAGLDEVRPGAKTGDIGHAIQSLAESRGYG-VVREYTGHGIGKRLHEDPT 191
Query: 302 IGPDG----EVTLENGMTFTIEPGI 322
I G + L+ GM FTIEP I
Sbjct: 192 IYHWGVHHTGLKLQPGMVFTIEPMI 216
>sp|P53581|AMP3_SYNY3 PUTATIVE METHIONINE AMINOPEPTIDASE C (MAP) (PEPTIDASE M)
>gi|7435548|pir||S75743 methionyl aminopeptidase (EC
3.4.11.18) 3 - Synechocystis sp. (strain PCC 6803)
>gi|1001237|dbj|BAA10478.1| (D64003) methionine
aminopeptidase [Synechocystis sp.]
Length = 305
Score = 76.1 bits (184), Expect = 6e-13
Identities = 62/201 (30%), Positives = 92/201 (44%), Gaps = 13/201 (6%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPI---- 187
K EI M+ A IA +V +EI + GM+ +L E RIR L SF
Sbjct: 57 KTPAEIAIMRQAGAIAAQVLKEIAATVQPGMTTGDLDQLAEERIRSLGATPSFKGYHGFP 116
Query: 188 --VASGENSANPHHEPGERK-IRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVY 244
+ + N+ H P RK IR GD++ +D GA ++GY D TIAVG+ + +
Sbjct: 117 ASICACVNNEVVHGIPRRRKKIRSGDLLKVDTGAYFQGYHGDSCITIAVGKVSPQAQRLM 176
Query: 245 EIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI-- 302
E+ + A V+ G ++ + + GY TGHG+G +HE+P++
Sbjct: 177 EVAEGALYAGIEQVKPGNYLMDIAGAIEDYVKPTGY-TIVEEFTGHGVGQALHEDPHVFN 235
Query: 303 ---GPDGEVTLENGMTFTIEP 320
V L+ GMT IEP
Sbjct: 236 VRCRDLPNVKLKPGMTLAIEP 256
>sp|P19213|CREA_FLASU CREATINASE (CREATINE AMIDINOHYDROLASE) >gi|2160260|dbj|BAA03359.1|
(D14464) creatinase [Flavobacterium sp.]
>gi|3410883|dbj|BAA32239.1| (D00656) creatinase
[Flavobacterium sp.] >gi|1097202|prf||2113324B
creatinase [Flavobacterium sp.]
Length = 403
Score = 75.7 bits (183), Expect = 8e-13
Identities = 69/240 (28%), Positives = 108/240 (44%), Gaps = 23/240 (9%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELAL---KIEVR-IRELSDGVS 183
MRM K EE E ++H AR+AD I+ + E E+AL + VR I E D V
Sbjct: 155 MRMIKSAEEHEMIRHGARVADIGGAAIVEALRDQVPEYEVALHATQAMVRAIAETFDNVE 214
Query: 184 FSPI---VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
SG N+ H+ RK+ KGDI+ L+ GY + + RT+ + +
Sbjct: 215 LMDTWTWFQSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDDH 274
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
+ +++ E E + ++ G++ ++ K E+ + +Y T GH G H
Sbjct: 275 LRMWQANVEVHEAGLKLIKPGMRCSDIAKELNEIFLKHDLLQYRTFGYGHSFGTLSH--- 331
Query: 301 YIG--------PDGEVTLENGMTFTIEPGIYI----PGLGGVRIEDDVVVEGKG-KRLTK 347
Y G D + LE GM ++EP I + PG GG R D ++V G + +TK
Sbjct: 332 YYGREAGLELREDIDTVLEPGMVVSMEPMIMLPEGRPGAGGYREHDILIVNENGAENITK 391
>pir||A75514 peptidase-related protein - Deinococcus radiodurans (strain R1)
>gi|6458166|gb|AAF10058.1|AE001907_4 (AE001907)
peptidase-related protein [Deinococcus radiodurans]
Length = 312
Score = 75.7 bits (183), Expect = 8e-13
Identities = 60/208 (28%), Positives = 100/208 (47%), Gaps = 24/208 (11%)
Query: 162 MSEKELALKIEVRIRELSDGVSFSPIVASGENSANPHHEPGERK---IRKGDIVILDYGA 218
++E E+ I +IR V+ G N+A+ H+EP E++ + G+ V++D A
Sbjct: 80 VTEWEVQQLIMDQIRAAGMQAGHDVNVSFGVNAADSHYEPSEQRSATLHPGECVLIDLWA 139
Query: 219 RWRGY-CSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIKAK--------EVDK 269
+ G +D+T G P + ++ ++ V+ A+E A +R A+ E+D+
Sbjct: 140 QEPGRPFADVTWVGFAGEPGTEYLDAWQAVRAAREAALELLRSRFVAEGYGRLQGWELDR 199
Query: 270 VAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGPDGEV----TLENGMTFTIEPGIYI- 324
AR+ + E + +F HRTGH LG+ +H D E TL G++ T+EPG Y
Sbjct: 200 AARDAMGER-WAPHFLHRTGHDLGVQIHGAGANLDDYETRDTRTLTPGLSVTVEPGTYPA 258
Query: 325 ------PGLGGVRIEDDVVVEGKGKRLT 346
G G+R E DV + G +T
Sbjct: 259 AASPSGQGGFGIRSEVDVYLAPDGPEVT 286
>sp|O83814|AMPM_TREPA METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435560|pir||B71273 probable methionine
aminopeptidase (map) - syphilis spirochete
>gi|3323157|gb|AAC65810.1| (AE001255) methionine
aminopeptidase (map) [Treponema pallidum]
Length = 255
Score = 74.9 bits (181), Expect = 1e-12
Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 20/218 (9%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIREL-------SDGVSF 184
K E+I+ ++ + + ++F+ ++ G+ +EL + IR + S+G
Sbjct: 5 KTPEQIDGIRASCKALARLFDVLIPLVKPGVQTQELDAFCQRFIRSVGGVPAWFSEGFPA 64
Query: 185 SPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVY 244
+ ++ E H P R I+ GD+V LD G GY SD RT+ VG + +E+
Sbjct: 65 AACISINEEVI--HGLPSARVIQDGDLVSLDVGINLNGYISDACRTVPVGGVAHERLELL 122
Query: 245 EIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI-- 302
+ E +A R G + + V + V + +G + + GHG+GL VHEEP I
Sbjct: 123 RVTTECLRAGIKACRAGARVRAVSRAVYAVAARHRFGVVYEY-CGHGVGLAVHEEPNIPN 181
Query: 303 -----GPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDD 335
GP+ GM IEP + + G VR D
Sbjct: 182 VPGLEGPNPRFL--PGMVVAIEPMLTL-GTDEVRTSAD 216
>pir||C82367 aminopeptidase P VC0067 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9654463|gb|AAF93245.1| (AE004098)
aminopeptidase P [Vibrio cholerae]
Length = 597
Score = 74.9 bits (181), Expect = 1e-12
Identities = 60/186 (32%), Positives = 96/186 (51%), Gaps = 19/186 (10%)
Query: 163 SEKELALKIEVRIRE---LSDGVSFSPIVASGENSANPHH------EPGERKIRKGDIVI 213
+E ELA ++E R+ L D +SF I A+G N+A H+ EPG+ + + +
Sbjct: 339 NEAELADRLEAFRRQDPTLVD-LSFDTISAAGTNAAMCHYNHQNQPEPGQ--LSMDSLYL 395
Query: 214 LDYGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRA-VREGIKAKEVDKVAR 272
+D G ++ +DITRT+A+G+ ++ + + +V + RA +G ++D +AR
Sbjct: 396 VDSGGQYLDGTTDITRTVAIGQVSAEMKQQFTLVLKGHIALARARFPKGTTGSQLDVLAR 455
Query: 273 EVISEAGYGEYFTHRTGHGLG--LDVHEEP--YIGPDGEVTLENGMTFTIEPGIYIPGLG 328
+ + GY + H TGHG+G L VHE P V L GM + EPG Y
Sbjct: 456 QHLWAQGYD--YDHGTGHGVGHFLSVHEGPQRIAKVHNSVALRPGMVLSNEPGYYRADAF 513
Query: 329 GVRIED 334
G+RIE+
Sbjct: 514 GIRIEN 519
>pdb|1CHM|B Chain B, Creatine Amidinohydrolase (E.C.3.5.3.3)
Length = 401
Score = 74.1 bits (179), Expect = 2e-12
Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 37/362 (10%)
Query: 14 NFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLA------PSLYSNVITNF 67
N D A + N+ Y + G RP LVV+ D + A P + N
Sbjct: 38 NIDAAIFTSYHNINYYSDFLYCSFG-RPYALVVTEDDVISISANIDGGQPWRRTVGTDNI 96
Query: 68 PVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHPLSSLIRL 127
T W+ +N +A + L + + + D L + + E +++
Sbjct: 97 VYTDWQR-DNYFAAIQQALPKARRIGIEHDHLNLQNRDKLAA--RYPDAELVDVAAACMR 153
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILG--MSEKELALKI-EVRIRELSDGVSF 184
MRM K EE ++H ARIAD ++ + LG + E E+AL + +R ++D
Sbjct: 154 MRMIKSAEEHVMIRHGARIADIGGAAVV--EALGDQVPEYEVALHATQAMVRAIADTFED 211
Query: 185 SPIV------ASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDE 238
++ SG N+ H+ RK+ KGDI+ L+ GY + + RT+ + +
Sbjct: 212 VELMDTWTWFQSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSD 271
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHE 298
+ ++++ E E + ++ G + ++ + E+ + +Y T GH G H
Sbjct: 272 DHLRLWQVNVEVHEAGLKLIKPGARCSDIARELNEIFLKHDVLQYRTFGYGHSFGTLSH- 330
Query: 299 EPYIG--------PDGEVTLENGMTFTIEPGIY----IPGLGGVRIEDDVVVEGKG-KRL 345
Y G D + LE GM ++EP I +PG GG R D ++V G + +
Sbjct: 331 --YYGREAGLELREDIDTVLEPGMVVSMEPMIMLPEGLPGAGGYREHDILIVNENGAENI 388
Query: 346 TK 347
TK
Sbjct: 389 TK 390
>sp|P38488|CREA_PSEPU CREATINASE (CREATINE AMIDINOHYDROLASE)
Length = 403
Score = 74.1 bits (179), Expect = 2e-12
Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 37/362 (10%)
Query: 14 NFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLA------PSLYSNVITNF 67
N D A + N+ Y + G RP LVV+ D + A P + N
Sbjct: 39 NIDAAIFTSYHNINYYSDFLYCSFG-RPYALVVTEDDVISISANIDGGQPWRRTVGTDNI 97
Query: 68 PVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHPLSSLIRL 127
T W+ +N +A + L + + + D L + + E +++
Sbjct: 98 VYTDWQR-DNYFAAIQQALPKARRIGIEHDHLNLQNRDKLAA--RYPDAELVDVAAACMR 154
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILG--MSEKELALKI-EVRIRELSDGVSF 184
MRM K EE ++H ARIAD ++ + LG + E E+AL + +R ++D
Sbjct: 155 MRMIKSAEEHVMIRHGARIADIGGAAVV--EALGDQVPEYEVALHATQAMVRAIADTFED 212
Query: 185 SPIV------ASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDE 238
++ SG N+ H+ RK+ KGDI+ L+ GY + + RT+ + +
Sbjct: 213 VELMDTWTWFQSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSD 272
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHE 298
+ ++++ E E + ++ G + ++ + E+ + +Y T GH G H
Sbjct: 273 DHLRLWQVNVEVHEAGLKLIKPGARCSDIARELNEIFLKHDVLQYRTFGYGHSFGTLSH- 331
Query: 299 EPYIG--------PDGEVTLENGMTFTIEPGIY----IPGLGGVRIEDDVVVEGKG-KRL 345
Y G D + LE GM ++EP I +PG GG R D ++V G + +
Sbjct: 332 --YYGREAGLELREDIDTVLEPGMVVSMEPMIMLPEGLPGAGGYREHDILIVNENGAENI 389
Query: 346 TK 347
TK
Sbjct: 390 TK 391
>pdb|1CHM|A Chain A, Creatine Amidinohydrolase (E.C.3.5.3.3)
Length = 401
Score = 74.1 bits (179), Expect = 2e-12
Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 37/362 (10%)
Query: 14 NFDGAFISPGSNLYYLTGLKLHEVGERPTILVVSADGEYKLLA------PSLYSNVITNF 67
N D A + N+ Y + G RP LVV+ D + A P + N
Sbjct: 38 NIDAAIFTSYHNINYYSDFLYCSFG-RPYALVVTEDDVISISANIDGGQPWRRTVGTDNI 96
Query: 68 PVTFWRDGENPYAKLSTILGELKLYRGRFLVEDTMRADWLIGILKLGNFEFHPLSSLIRL 127
T W+ +N +A + L + + + D L + + E +++
Sbjct: 97 VYTDWQR-DNYFAAIQQALPKARRIGIEHDHLNLQNRDKLAA--RYPDAELVDVAAACMR 153
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILG--MSEKELALKI-EVRIRELSDGVSF 184
MRM K EE ++H ARIAD ++ + LG + E E+AL + +R ++D
Sbjct: 154 MRMIKSAEEHVMIRHGARIADIGGAAVV--EALGDQVPEYEVALHATQAMVRAIADTFED 211
Query: 185 SPIV------ASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDE 238
++ SG N+ H+ RK+ KGDI+ L+ GY + + RT+ + +
Sbjct: 212 VELMDTWTWFQSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSD 271
Query: 239 KLIEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHE 298
+ ++++ E E + ++ G + ++ + E+ + +Y T GH G H
Sbjct: 272 DHLRLWQVNVEVHEAGLKLIKPGARCSDIARELNEIFLKHDVLQYRTFGYGHSFGTLSH- 330
Query: 299 EPYIG--------PDGEVTLENGMTFTIEPGIY----IPGLGGVRIEDDVVVEGKG-KRL 345
Y G D + LE GM ++EP I +PG GG R D ++V G + +
Sbjct: 331 --YYGREAGLELREDIDTVLEPGMVVSMEPMIMLPEGLPGAGGYREHDILIVNENGAENI 388
Query: 346 TK 347
TK
Sbjct: 389 TK 390
>gi|11499425 methionyl aminopeptidase (map) [Archaeoglobus fulgidus]
>gi|3122371|sp|O28438|AMPM_ARCFU METHIONINE
AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435552|pir||G69479 methionyl aminopeptidase (map)
homolog - Archaeoglobus fulgidus
>gi|2648708|gb|AAB89413.1| (AE000976) methionyl
aminopeptidase (map) [Archaeoglobus fulgidus]
Length = 291
Score = 73.7 bits (178), Expect = 3e-12
Identities = 62/196 (31%), Positives = 91/196 (45%), Gaps = 16/196 (8%)
Query: 133 DREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPIVASGE 192
D E E + A +I + E G+ E+A +E RI EL +F ++
Sbjct: 2 DDEVREKLIEAGKILKQAVNEAAEKIAPGVKILEVAEFVENRIIELGAKPAFPANISINS 61
Query: 193 NSANPHHEP---GERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKE 249
++A H P ER ++GD+V LD GA GY +D+ T+ +G E+ + KE
Sbjct: 62 DAA--HFTPKKNDERTFKEGDVVKLDVGAHIDGYIADMAVTVDLG----DNTELVKAAKE 115
Query: 250 AQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP-----YIGP 304
A E A VR G+ E+ K + I+ G+ + + TGHGL ++ P Y
Sbjct: 116 ALEAAMEVVRAGVSVSEIGKAIEDAITNYGF-KPIVNLTGHGLLPYLNHAPPSIYNYATE 174
Query: 305 DGEVTLENGMTFTIEP 320
G VTLE GM IEP
Sbjct: 175 KG-VTLEEGMVVAIEP 189
>pir||A81262 methionyl aminopeptidase (EC 3.4.11.18) Cj1651c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6969068|emb|CAB73639.1| (AL139079) methionine
aminopeptidase [Campylobacter jejuni]
Length = 252
Score = 73.7 bits (178), Expect = 3e-12
Identities = 60/205 (29%), Positives = 91/205 (44%), Gaps = 15/205 (7%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPI---- 187
K +EIE ++ A +I K + + +GMS K++ E I L SF +
Sbjct: 5 KKPDEIEKLRIANQIVAKTLNFLENEIKIGMSLKQIDKMAEDYILSLGAKPSFKGLYGFP 64
Query: 188 --VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYE 245
+ + N H P ++ I++GDI+ LD G+ GY D RTIA+G +
Sbjct: 65 GAICTSLNQVCIHGIPDDKIIKEGDILGLDVGSLIDGYYGDAARTIAIGEVSPADKALIS 124
Query: 246 IVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI--- 302
K+A A +R+G++ KE+ E I G+ + GHG+G H EP I
Sbjct: 125 CAKDALYHAIDIIRDGMRFKELSAALGEFIHVRGFVPLRGY-CGHGIGRKPHGEPEILNY 183
Query: 303 -----GPDGEVTLENGMTFTIEPGI 322
++NGM F IEP I
Sbjct: 184 LEKGASAKSGPKIKNGMVFCIEPMI 208
>sp|P07906|AMPM_ECOLI METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M) >gi|67532|pir||DPECM
methionyl aminopeptidase (EC 3.4.11.18) [validated] -
Escherichia coli >gi|494313|pdb|1MAT| Methionine
Aminopeptidase (E.C.3.4.11.18) >gi|146727|gb|AAA24112.1|
(M15106) methionine amino peptidase [Escherichia coli]
>gi|473823|dbj|BAA05612.1| (D26562) 'methionine
aminopeptidase' [Escherichia coli]
>gi|1552745|gb|AAB08597.1| (U70214) methionine
aminopeptidase [Escherichia coli]
>gi|1786364|gb|AAC73279.1| (AE000126) methionine
aminopeptidase [Escherichia coli K12]
Length = 264
Score = 73.4 bits (177), Expect = 4e-12
Identities = 62/201 (30%), Positives = 89/201 (43%), Gaps = 13/201 (6%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVS-------F 184
K E+IE M+ A R+A +V E I + G+S EL I VS +
Sbjct: 6 KTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGY 65
Query: 185 SPIVASGENSANPHHEPGERKIRK-GDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
V N H P + K+ K GDIV +D G+ D ++ VG+P +
Sbjct: 66 PKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERL 125
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP--- 300
I +E+ A R V+ GI +E+ ++ + G+ GHG+G HEEP
Sbjct: 126 CRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGRGFHEEPQVL 184
Query: 301 -YIGPDGEVTLENGMTFTIEP 320
Y + V L+ GMTFTIEP
Sbjct: 185 HYDSRETNVVLKPGMTFTIEP 205
>gb|AAD37463.1| (AF072304) creatinase [Pseudomonas putida]
Length = 403
Score = 73.4 bits (177), Expect = 4e-12
Identities = 65/240 (27%), Positives = 109/240 (45%), Gaps = 23/240 (9%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKI-EVRIRELSDGVSFSP 186
MRM K EE ++ AR+AD ++ + E E+AL + +RE++ S
Sbjct: 155 MRMIKSAEEHAIIRQGARVADIGGAAVVEALRDQVPEYEVALHATQAMVREIARTYPDSE 214
Query: 187 IV------ASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
++ SG N+ H+ RK+ KGDI+ L+ GY + + RT+ + ++
Sbjct: 215 LMDTWTWFQSGINTDGAHNPVTSRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDEH 274
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
+ ++E+ + E V+ G+++ ++ E+ E +Y T GH G H
Sbjct: 275 LRLWEVNVKVHEAGLELVKPGMRSSDIALQLNEIFLEHDLLQYRTFGYGHSFGTLSH--- 331
Query: 301 YIG--------PDGEVTLENGMTFTIEPGIY----IPGLGGVRIEDDVVVEGKG-KRLTK 347
Y G D + LE GM +IEP I +PG GG R D ++V G + +TK
Sbjct: 332 YYGREAGLELREDIDTVLEPGMVVSIEPMIMLPEGLPGAGGYREHDILIVNEHGSENITK 391
>pdb|2MAT|A Chain A, E.Coli Methionine Aminopeptidase At 1.9 Angstrom
Resolution
Length = 264
Score = 73.4 bits (177), Expect = 4e-12
Identities = 62/201 (30%), Positives = 89/201 (43%), Gaps = 13/201 (6%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVS-------F 184
K E+IE M+ A R+A +V E I + G+S EL I VS +
Sbjct: 6 KTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGY 65
Query: 185 SPIVASGENSANPHHEPGERKIRK-GDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
V N H P + K+ K GDIV +D G+ D ++ VG+P +
Sbjct: 66 PKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERL 125
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP--- 300
I +E+ A R V+ GI +E+ ++ + G+ GHG+G HEEP
Sbjct: 126 CRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVL 184
Query: 301 -YIGPDGEVTLENGMTFTIEP 320
Y + V L+ GMTFTIEP
Sbjct: 185 HYDSRETNVVLKPGMTFTIEP 205
>pdb|1C22|A Chain A, E. Coli Methionine Aminopeptidase: Trifluoromethionine
Complex >gi|6573514|pdb|1C23|A Chain A, E. Coli
Methionine Aminopeptidase: Methionine Phosphonate
Complex >gi|6573515|pdb|1C24|A Chain A, E. Coli
Methionine Aminopeptidase: Methionine Phosphinate
Complex >gi|6573394|pdb|1C27|A Chain A, E. Coli
Methionine Aminopeptidase:norleucine Phosphonate Complex
>gi|6573512|pdb|1C21|A Chain A, E. Coli Methionine
Aminopeptidase: Methionine Complex
Length = 263
Score = 73.4 bits (177), Expect = 4e-12
Identities = 62/201 (30%), Positives = 89/201 (43%), Gaps = 13/201 (6%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVS-------F 184
K E+IE M+ A R+A +V E I + G+S EL I VS +
Sbjct: 5 KTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGY 64
Query: 185 SPIVASGENSANPHHEPGERKIRK-GDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
V N H P + K+ K GDIV +D G+ D ++ VG+P +
Sbjct: 65 PKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERL 124
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP--- 300
I +E+ A R V+ GI +E+ ++ + G+ GHG+G HEEP
Sbjct: 125 CRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVL 183
Query: 301 -YIGPDGEVTLENGMTFTIEP 320
Y + V L+ GMTFTIEP
Sbjct: 184 HYDSRETNVVLKPGMTFTIEP 204
>pdb|3MAT|A Chain A, E.Coli Methionine Aminopeptidase Transition-State
Inhibitor Complex
Length = 265
Score = 73.4 bits (177), Expect = 4e-12
Identities = 62/201 (30%), Positives = 89/201 (43%), Gaps = 13/201 (6%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVS-------F 184
K E+IE M+ A R+A +V E I + G+S EL I VS +
Sbjct: 6 KTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGY 65
Query: 185 SPIVASGENSANPHHEPGERKIRK-GDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
V N H P + K+ K GDIV +D G+ D ++ VG+P +
Sbjct: 66 PKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERL 125
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP--- 300
I +E+ A R V+ GI +E+ ++ + G+ GHG+G HEEP
Sbjct: 126 CRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVL 184
Query: 301 -YIGPDGEVTLENGMTFTIEP 320
Y + V L+ GMTFTIEP
Sbjct: 185 HYDSRETNVVLKPGMTFTIEP 205
>pdb|4MAT|A Chain A, E.Coli Methionine Aminopeptidase His79ala Mutant
Length = 278
Score = 73.4 bits (177), Expect = 4e-12
Identities = 62/201 (30%), Positives = 89/201 (43%), Gaps = 13/201 (6%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVS-------F 184
K E+IE M+ A R+A +V E I + G+S EL I VS +
Sbjct: 6 KTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGY 65
Query: 185 SPIVASGENSANPHHEPGERKIRK-GDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
V N H P + K+ K GDIV +D G+ D ++ VG+P +
Sbjct: 66 PKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERL 125
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP--- 300
I +E+ A R V+ GI +E+ ++ + G+ GHG+G HEEP
Sbjct: 126 CRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGF-SVVREYCGHGIGQGFHEEPQVL 184
Query: 301 -YIGPDGEVTLENGMTFTIEP 320
Y + V L+ GMTFTIEP
Sbjct: 185 HYDSRETNVVLKPGMTFTIEP 205
>sp|O58362|AMPM_PYRHO METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M)
>gi|7435554|pir||C71107 probable methionyl
aminopeptidase - Pyrococcus horikoshii
>gi|3257034|dbj|BAA29717.1| (AP000003) 295aa long
hypothetical methionyl aminopeptidase [Pyrococcus
horikoshii]
Length = 295
Score = 73.0 bits (176), Expect = 5e-12
Identities = 58/191 (30%), Positives = 90/191 (46%), Gaps = 10/191 (5%)
Query: 136 EIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPIVASGENSA 195
+++ + A +IA KV EE + G+S ELA KIE RI EL +F ++ E +A
Sbjct: 2 DVDKLIEAGKIAKKVREEAVKLAKPGVSLLELAEKIESRIVELGGKPAFPANLSLNEVAA 61
Query: 196 NPHHEPGERKI-RKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKA 254
+ G++ + ++GD + +D G GY +D T+ VG ++L+E KEA E A
Sbjct: 62 HYTPYKGDQTVLKEGDYLKIDLGVHIDGYIADTAVTVRVGMDFDELMEA---AKEALESA 118
Query: 255 YRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGH-----GLGLDVHEEPYIGPDGEVT 309
R G++ KE+ K I + G+ + +GH L V P
Sbjct: 119 ISVARAGVEVKELGKAIENEIRKRGFNP-IVNLSGHKIERYKLHAGVSIPNIYRPHDNYV 177
Query: 310 LENGMTFTIEP 320
L+ G F IEP
Sbjct: 178 LQEGDVFAIEP 188
>gb|AAD52565.4|AF170566_1 (AF170566) creatinase [Pseudomonas putida]
Length = 403
Score = 73.0 bits (176), Expect = 5e-12
Identities = 65/240 (27%), Positives = 108/240 (44%), Gaps = 23/240 (9%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKI-EVRIRELSDGVSFSP 186
MRM K EE ++ AR+AD ++ + E E+AL + +RE++ S
Sbjct: 155 MRMIKSAEEHAIIRQGARVADIGGAAVVEALRDQVPEYEVALHATQAMVREIARTYPDSE 214
Query: 187 IV------ASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKL 240
++ SG N+ H+ RK+ KGDI+ L+ GY + + RT+ + ++
Sbjct: 215 LMDTWTWFQSGINTDGAHNPVTSRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDEH 274
Query: 241 IEVYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP 300
+ ++E+ + E V+ G++ ++ E+ E +Y T GH G H
Sbjct: 275 LRLWEVNVKVHEAGLELVKPGMRCSDIALQLNEIFLEHDLLQYRTFGYGHSFGTLSH--- 331
Query: 301 YIG--------PDGEVTLENGMTFTIEPGIY----IPGLGGVRIEDDVVVEGKG-KRLTK 347
Y G D + LE GM +IEP I +PG GG R D ++V G + +TK
Sbjct: 332 YYGREAGLELREDIDTVLEPGMVVSIEPMIMLPEGLPGAGGYREHDILIVNEHGSENITK 391
>sp|P19994|AMPM_BACSU METHIONINE AMINOPEPTIDASE (MAP) (PEPTIDASE M) >gi|80333|pir||JS0493
methionyl aminopeptidase (EC 3.4.11.18) map - Bacillus
subtilis >gi|216341|dbj|BAA00497.1| (D00619) methionine
amino peptidase [Bacillus subtilis]
>gi|1044986|gb|AAB06821.1| (L47971) methionine
aminopeptidase [Bacillus subtilis]
>gi|2632405|emb|CAB11914.1| (Z99104) methionine
aminopeptidase [Bacillus subtilis]
Length = 248
Score = 72.6 bits (175), Expect = 7e-12
Identities = 59/204 (28%), Positives = 89/204 (42%), Gaps = 21/204 (10%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELA------LKIEVRIRELSDGVSFS 185
K E+ M+ A RI EE+ G+S KEL +K + I F
Sbjct: 5 KTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIAERFIKKQGAIPSFKGYNGFR 64
Query: 186 PIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGR---PDEKLIE 242
+ N H PG R ++ GDI+ +D GA+ GY D T VG D+KL+E
Sbjct: 65 GSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGYHGDSAWTYPVGNISDDDKKLLE 124
Query: 243 VYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHR--TGHGLGLDVHEEP 300
V E E Y+ ++E + + ++ + + ++ R GHG+G D+HE+P
Sbjct: 125 VTE------ESLYKGLQEAKPGERLSNISHAIQTYVENEQFSVVREYVGHGVGQDLHEDP 178
Query: 301 ----YIGPDGEVTLENGMTFTIEP 320
Y P+ L+ GM IEP
Sbjct: 179 QIPHYGPPNKGPRLKPGMVLAIEP 202
>pir||E82845 methionine aminopeptidase XF0111 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9104893|gb|AAF82924.1|AE003865_1
(AE003865) methionine aminopeptidase [Xylella
fastidiosa]
Length = 259
Score = 72.2 bits (174), Expect = 9e-12
Identities = 65/236 (27%), Positives = 102/236 (42%), Gaps = 13/236 (5%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGV-------SF 184
K +EEIE M+ A R+A V + + + G++ EL I + + F
Sbjct: 7 KTKEEIEQMRIAGRLAATVLDVVAPYVKPGVTTAELDQICHDYIVTVQGAIPANLGYRGF 66
Query: 185 SPIVASGENSANPHHEPGERKIRK-GDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
+ + N+ H P + K+ K GDI+ +D G+ D +R VG P +
Sbjct: 67 PKTICTSVNNVICHGIPSDAKVLKDGDIINIDVTVIKDGWHGDTSRMYYVGNPSVMARRL 126
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI- 302
E EA + RAV+ G ++ A ++ +E GHG+G H+ P +
Sbjct: 127 VETTYEAMWRGIRAVKPGATLGDIGH-AIQIYAENERFSVVREYCGHGIGKVYHDNPQVL 185
Query: 303 --GPDGE-VTLENGMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGRELITV 355
G GE + LE+GMTFTIEP I + D V K ++L+ +I V
Sbjct: 186 HYGRPGEGLVLESGMTFTIEPMINEGTRHHKVLPDGWTVVTKDRKLSAQWEHMIAV 241
>gb|AAD27841.1|AF124600_4 (AF124600) putative cytoplasmic peptidase [Corynebacterium
glutamicum]
Length = 217
Score = 71.8 bits (173), Expect = 1e-11
Identities = 38/97 (39%), Positives = 63/97 (64%), Gaps = 3/97 (3%)
Query: 117 EFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDIL--GMSEKELALKIEVR 174
E P+S ++ +R+ KD E++ ++ A +A + FE++L+ L G SE+++A +E R
Sbjct: 121 ELIPVSGVVESIRLTKDSFELDRLRDVAALASQAFEDLLAAGELAEGRSERQVAADLEYR 180
Query: 175 IREL-SDGVSFSPIVASGENSANPHHEPGERKIRKGD 210
+R L ++ SF IVASG NSA PHH G+R +++GD
Sbjct: 181 MRLLGAERPSFDTIVASGPNSAKPHHGAGDRILQRGD 217
>gi|6322999 Yll029wp [Saccharomyces cerevisiae] >gi|2131729|pir||S64780
hypothetical protein YLL029w - yeast (Saccharomyces
cerevisiae) >gi|1360212|emb|CAA97478.1| (Z73134) ORF
YLL029w [Saccharomyces cerevisiae]
Length = 749
Score = 71.4 bits (172), Expect = 1e-11
Identities = 101/400 (25%), Positives = 176/400 (43%), Gaps = 64/400 (16%)
Query: 4 DRFVKLLNEMNFDGAFISPGSNLY---------YLTGLKLHEVGERPTILVVSADGEYKL 54
D+ KLL ++N + + G N + +L L+ ++ P A E +
Sbjct: 303 DKKEKLLKKLNDKASSATTGRNTFIVVALDEICWLLNLRGSDIDYNPVFFSYVAINEDET 362
Query: 55 LAPSLYSNVITNFPVTFW--------RDGENPYAKLSTILGELKLYRGRFLVEDTMRADW 106
+ L++N N ++ + R E + L+ I + FL+ D+ A W
Sbjct: 363 I---LFTNNPFNDDISEYFKINGIEVRPYEQIWEHLTKITSQASSAEHEFLIPDS--ASW 417
Query: 107 LI-----------GIL--KLGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKV-FE 152
+ G + K+ F + S I +++ K+ EI+N H A++ D V
Sbjct: 418 QMVRCLNTSTNANGAIAKKMTAQNFAIIHSPIDVLKSIKNDIEIKNA-HKAQVKDAVCLV 476
Query: 153 EILSW---DILG----MSEKELALKI-EVRIRELSD-GVSFSPIVASGENSANPHHEP-- 201
+ +W ++G + E A K+ E+R + + G SF I ++G N+A H+ P
Sbjct: 477 QYFAWLEQQLVGREALIDEYRAAEKLTEIRKTQRNFMGNSFETISSTGSNAAIIHYSPPV 536
Query: 202 -GERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRAV-R 259
I I + D G+++ +DITRTI + +P ++ ++ Y +V + R +
Sbjct: 537 ENSSMIDPTKIYLCDSGSQFLEGTTDITRTIHLTKPTKEEMDNYTLVLKGGLALERLIFP 596
Query: 260 EGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLG--LDVHEEPYIGPDGEVTLEN----- 312
E +D +AR+ + G + H TGHG+G L+VHE P +G L N
Sbjct: 597 ENTPGFNIDAIARQFLWSRGLD--YKHGTGHGIGSFLNVHEGP-MGVGFRPHLMNFPLRA 653
Query: 313 GMTFTIEPGIYIPGLGGVRIEDDVVVEGKGKRLTKAGREL 352
G + EPG Y G G+RIE D+++ K+ T+ G L
Sbjct: 654 GNIISNEPGYYKDGEYGIRIESDMLI----KKATEKGNFL 689
>emb|CAB16823.1| (Z99708) aminopeptidase-like protein [Arabidopsis thaliana]
>gi|7270625|emb|CAB80342.1| (AL161590)
aminopeptidase-like protein [Arabidopsis thaliana]
Length = 634
Score = 71.0 bits (171), Expect = 2e-11
Identities = 58/168 (34%), Positives = 83/168 (48%), Gaps = 12/168 (7%)
Query: 181 GVSFSPIVASGENSANPHHEPGERKIRKGD---IVILDYGARWRGYCSDITRTIAVGRPD 237
G+SF I + G N+A H+ P + D I + D GA++ +DITRT+ G+P
Sbjct: 392 GLSFPTISSVGSNAAVIHYSPEPEACAEMDPDKIYLCDSGAQYLDGTTDITRTVHFGKPS 451
Query: 238 EKLIEVYEIVKEAQEKAYRA-VREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLG--L 294
E Y V + A +G +D +AR + + YG + H TGHG+G L
Sbjct: 452 AHEKECYTAVFKGHVALGNARFPKGTNGYTLDILARAPLWK--YGLDYRHGTGHGVGSYL 509
Query: 295 DVHEEPY---IGPDGE-VTLENGMTFTIEPGIYIPGLGGVRIEDDVVV 338
VHE P+ P V L+ MT T EPG Y G G+R+E+ +VV
Sbjct: 510 CVHEGPHQVSFRPSARNVPLQATMTVTDEPGYYEDGNFGIRLENVLVV 557
>pir||C75054 methionyl aminopeptidase (EC 3.4.11.18) map PAB1434 - Pyrococcus
abyssi (strain Orsay) >gi|5458841|emb|CAB50328.1|
(AJ248287) methionine aminopeptidase (map) (EC
3.4.11.18) [Pyrococcus abyssi]
Length = 295
Score = 70.6 bits (170), Expect = 3e-11
Identities = 57/193 (29%), Positives = 90/193 (46%), Gaps = 14/193 (7%)
Query: 136 EIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPIVASGENSA 195
+++ + A +IA KV EE + G+S ELA KIE RI EL +F ++ E +A
Sbjct: 2 DVDKLIEAGKIAKKVREEAVKLAKPGVSLLELAEKIEGRIIELGAKPAFPVNLSLNEIAA 61
Query: 196 NPHHEP---GERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQE 252
H+ P E +++GD + +D G GY +D T+ VG ++ L+E +EA E
Sbjct: 62 --HYTPYKGDETTLKEGDYLKIDIGVHIDGYIADTAVTVRVGMEEDDLMEA---AREALE 116
Query: 253 KAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGH-----GLGLDVHEEPYIGPDGE 307
A R G++ KE+ + + I + G+ + +GH L + P
Sbjct: 117 SAISVARAGVEIKELGRAIEDEIRKRGFNP-IVNLSGHKIERYKLHAGISIPNIYRPHDN 175
Query: 308 VTLENGMTFTIEP 320
L G F IEP
Sbjct: 176 YKLREGDVFAIEP 188
>dbj|BAA95761.1| (AB028607) methionine aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 342
Score = 70.2 bits (169), Expect = 3e-11
Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 13/194 (6%)
Query: 137 IENMKHAARIADKVFE-------EILSWDILGMSEKELALKIEVRIRELSDGVSFSPIVA 189
I MK A +A +V + ++ D + + ++ ++ L G F V
Sbjct: 105 IVKMKKACELAARVLDYAGTLVRPFVTTDEIDKAVHQMVIEFGAYPSPLGYG-GFPKSVC 163
Query: 190 SGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKE 249
+ N H P R ++ GDI+ +D GY D ++T G + L ++ ++ +E
Sbjct: 164 TSVNECMFHGIPDSRPLQNGDIINIDVAVYLDGYHGDTSKTFLCGDVNGSLKQLVKVTEE 223
Query: 250 AQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGPDGEVT 309
EK ++G K++ K+ E A YG GHG+G +H EP I +
Sbjct: 224 CLEKGISVCKDGASFKQIGKIISE--HAAKYGYNMERFIGHGVGTVLHSEPLIYLHNDYE 281
Query: 310 LE---NGMTFTIEP 320
LE G TFT+EP
Sbjct: 282 LEYMIEGQTFTLEP 295
>dbj|BAB03321.1| (AB035448) methionin aminopeptidase [Staphylococcus aureus]
Length = 252
Score = 69.9 bits (168), Expect = 4e-11
Identities = 58/205 (28%), Positives = 86/205 (41%), Gaps = 17/205 (8%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPI---- 187
K EE++ +K I KV + + G++ KEL + E G +PI
Sbjct: 4 KTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEY--GAISAPIHDEN 61
Query: 188 ----VASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIE- 242
N H P +R IR+GD+V +D A GY +D + VG D+ + +
Sbjct: 62 FPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQK 121
Query: 243 VYEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP-- 300
V ++ A E A V+ G K + K + + + TGHG+GL +HE P
Sbjct: 122 VCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDL-KVIKNLTGHGVGLSLHEAPAH 180
Query: 301 ---YIGPDGEVTLENGMTFTIEPGI 322
Y P + L GM IEP I
Sbjct: 181 VLNYFDPKDKTLLTEGMVLAIEPFI 205
>emb|CAB16790.1| (Z99707) methionyl aminopeptidase-like protein [Arabidopsis
thaliana] >gi|7270653|emb|CAB80370.1| (AL161590)
methionyl aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 305
Score = 69.5 bits (167), Expect = 6e-11
Identities = 53/186 (28%), Positives = 81/186 (43%), Gaps = 18/186 (9%)
Query: 184 FSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
F V + N H P R + GDI+ +D GY D + T G DEK ++
Sbjct: 121 FPKSVCTSVNECICHGIPDSRPLEDGDIINIDVTVYLNGYHGDTSATFFCGNVDEKAKKL 180
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI- 302
E+ KE+ +KA G++ K++ KV ++ + YG GHG+G H +P +
Sbjct: 181 VEVTKESLDKAISICGPGVEYKKIGKVIHDLADKHKYG-VVRQFVGHGVGSVFHADPVVL 239
Query: 303 ----GPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDD--VVVEGKGKR--------LTKA 348
G + L TFTIEP + I + +D+ VV E +TK
Sbjct: 240 HFRNNEAGRMVL--NQTFTIEPMLTIGSRNPIMWDDNWTVVTEDASLSAQFEHTILITKD 297
Query: 349 GRELIT 354
G E++T
Sbjct: 298 GAEILT 303
>gb|AAG33977.1|AF250963_1 (AF250963) methionine aminopeptidase-like protein [Arabidopsis
thaliana]
Length = 350
Score = 69.5 bits (167), Expect = 6e-11
Identities = 53/186 (28%), Positives = 81/186 (43%), Gaps = 18/186 (9%)
Query: 184 FSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
F V + N H P R + GDI+ +D GY D + T G DEK ++
Sbjct: 166 FPKSVCTSVNECICHGIPDSRPLEDGDIINIDVTVYLNGYHGDTSATFFCGNVDEKAKKL 225
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYI- 302
E+ KE+ +KA G++ K++ KV ++ + YG GHG+G H +P +
Sbjct: 226 VEVTKESLDKAISICGPGVEYKKIGKVIHDLADKHKYG-VVRQFVGHGVGSVFHADPVVL 284
Query: 303 ----GPDGEVTLENGMTFTIEPGIYIPGLGGVRIEDD--VVVEGKGKR--------LTKA 348
G + L TFTIEP + I + +D+ VV E +TK
Sbjct: 285 HFRNNEAGRMVL--NQTFTIEPMLTIGSRNPIMWDDNWTVVTEDASLSAQFEHTILITKD 342
Query: 349 GRELIT 354
G E++T
Sbjct: 343 GAEILT 348
>sp|P55666|Y4TL_RHISN HYPOTHETICAL HYDROLASE/PEPTIDASE Y4TL >gi|2182642|gb|AAB91865.1|
(AE000098) Y4tL [Rhizobium sp. NGR234]
Length = 390
Score = 69.1 bits (166), Expect = 8e-11
Identities = 62/234 (26%), Positives = 105/234 (44%), Gaps = 8/234 (3%)
Query: 128 MRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALKIEVRIRELSDGVSFSPI 187
+RM K EI M+ AA IAD ++ G+ E ++ + ++ ++G + + +
Sbjct: 159 IRMIKSDLEISMMRDAAAIADAGVQKAFEVIRPGVREADVMADVAAQLARGTNGKAGTDL 218
Query: 188 VA----SGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEV 243
+ S + H E IR G + L+ GY S I RT +VG P ++L +
Sbjct: 219 ASMYFCSSPRTGTCHIRWSEDVIRDGSQINLEIAGVRHGYVSAIMRTFSVGAPSDRLRRI 278
Query: 244 YEIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIG 303
++ E A V+ G +V I ++G+ + R G+ +G+D E
Sbjct: 279 HDAEVLGLEAALSTVKPGATCSDVANAFYRTIEKSGFQK--DSRCGYAIGIDWSEPTASL 336
Query: 304 PDGEVT-LENGMTFTIEPGIYI-PGLGGVRIEDDVVVEGKGKRLTKAGRELITV 355
DG++T L+ MTF + G +I G V E V E + LTK+ R+L +
Sbjct: 337 KDGDMTKLKPNMTFHLMLGNWIEEDFGYVLSETFRVTEAGCEVLTKSPRQLCVI 390
>gb|AAC16431.1| (AF063007) similar to the peptidase family M; Pfam domain PF00557
(pep_M24), Score=99.2, E-value=2.6e-26, N=1
[Caenorhabditis elegans]
Length = 383
Score = 69.1 bits (166), Expect = 8e-11
Identities = 66/271 (24%), Positives = 113/271 (41%), Gaps = 41/271 (15%)
Query: 115 NFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELA--LKIE 172
N F + I R+ K E+ +M+ + + ++S +E + L+ E
Sbjct: 105 NSNFVQFLNEIERRRVIKSPSEMSSMRDVCNVGAQTMSSMISGSRDLHNENAICGLLEFE 164
Query: 173 VRIRELSDGVSFSPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIA 232
R R S+ ++ P++A G + H+ + + V++D G GY SD+TR
Sbjct: 165 GR-RRGSEMQAYPPVIAGGVRANTIHYLDANNDLNPRECVLVDAGCDLNGYVSDVTRCFP 223
Query: 233 V-GRPDEKLIEVYEIVKEAQEK------AYRAVREGIKAKEVDKVAREVISEAGY----- 280
+ G + + +YE + E+ + VR + ++++ +E G
Sbjct: 224 ISGFWSDAQLSLYEALLYVHEELLTYAHSMEKVRLSALFRRMNELLAASFTELGLIRSTD 283
Query: 281 --------GEYFTHRTGHGLGLDVHEEPYIGPDGEVTLENGMTFTIEPGIYIP------- 325
+ H H LG+DVH+ P + D + L + FTIEPG+Y+P
Sbjct: 284 HKEMIHQAEKLCPHHVSHYLGMDVHDCPTVSRD--IDLPPNVPFTIEPGVYVPMDWPVKE 341
Query: 326 --GLGGVRIEDDVVVEGKGKRLTKAGRELIT 354
G+ G RIEDDV G G EL+T
Sbjct: 342 FRGI-GYRIEDDVATSEAG------GIELLT 365
>gb|AAF47587.1| (AE003473) dre4 gene product [Drosophila melanogaster]
Length = 1083
Score = 68.7 bits (165), Expect = 1e-10
Identities = 58/238 (24%), Positives = 104/238 (43%), Gaps = 34/238 (14%)
Query: 111 LKLGNFEFHPLSSLIRLMRMRKDREEIENMKHAARIADKVFEEILSWDILGMSEKELALK 170
L FE +S++I + KD EI N++ A+ ++ +F + L +I+ + + +
Sbjct: 116 LTASKFEHVDISTIIAYLMCPKDESEINNIRKASLVSMDIFNKYLKDEIMDIIDSDR--- 172
Query: 171 IEVRIRELSDG--------------------VSFSPIVASGENSANPHHEPGERKIRKGD 210
+V+ +LSDG +++ PI+ SG + ++
Sbjct: 173 -KVKHNKLSDGCEAAIGEKKYTSGLDPRLLDMAYPPIIQSGGAYSLKFSAVADKNPLHFG 231
Query: 211 IVILDYGARWRGYCSDITRTIAVGRPDEKLIEVYEIVKEAQEKAYRAVREGIK-----AK 265
+++ GAR++ YCS+I+RT V P E + E Y + QE+ + + G K K
Sbjct: 232 VIVCSLGARYKSYCSNISRTFLV-NPTEAMQENYTFLVSVQEEILKLLVPGTKLCDVYEK 290
Query: 266 EVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEP-YIGPDGEVTLENGMTFTIEPGI 322
+D V +E S + G +GL+ E IGP + L+ M F + GI
Sbjct: 291 TLDFVKKEKPSMV---DNLPKSFGFAMGLEFRENSIVIGPKCQALLKKNMVFNLHVGI 345
>pir||D83189 methionine aminopeptidase PA3657 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9949818|gb|AAG07045.1|AE004785_9 (AE004785)
methionine aminopeptidase [Pseudomonas aeruginosa]
Length = 261
Score = 68.7 bits (165), Expect = 1e-10
Identities = 54/202 (26%), Positives = 91/202 (44%), Gaps = 12/202 (5%)
Query: 132 KDREEIENMKHAARIADKVFEEILSWDILGMSEKEL-------ALKIEVRIRELSDGVSF 184
K ++IE M+ A R+A +V E I G++ +EL + + I + F
Sbjct: 6 KTPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVNEQKAIPAPLNYKGF 65
Query: 185 SPIVASGENSANPHHEPGERKIRKGDIVILDYGARWRGYCSDITRTIAVGRPDEKLIEVY 244
+ + N H P E+ +++GDI+ +D GY D ++ VG+ E +
Sbjct: 66 PKSICTSINHVVCHGIPNEKPLKEGDILNVDITVIKDGYHGDTSKMFLVGKTPEWADRLC 125
Query: 245 EIVKEAQEKAYRAVREGIKAKEVDKVAREVISEAGYGEYFTHRTGHGLGLDVHEEPYIGP 304
+I +E K VR G ++ ++ ++ + G+ GHG+G HEEP +
Sbjct: 126 QITQECMYKGISVVRPGAHLGDIGEIIQKHAEKNGF-SVVREYCGHGIGKVFHEEPQVLH 184
Query: 305 DGE----VTLENGMTFTIEPGI 322
G + L+ GM FTIEP I
Sbjct: 185 YGRAGTGIELKEGMIFTIEPMI 206
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.141 0.409
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 137619649
Number of Sequences: 2977
Number of extensions: 6096631
Number of successful extensions: 14928
Number of sequences better than 1.0e-10: 131
Number of HSP's better than 0.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 14585
Number of HSP's gapped (non-prelim): 147
length of query: 355
length of database: 189,106,746
effective HSP length: 55
effective length of query: 300
effective length of database: 156,189,961
effective search space: 46856988300
effective search space used: 46856988300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)