BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1782 (leuS) DE:leucyl-tRNA synthetase (leuS)
(967 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||H75133 leucyl-tRNA synthetase (leus) PAB1782 - Pyrococcus a... 1996 0.0
sp|O58698|SYL_PYRHO LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 1864 0.0
pir||A64379 isoleucine--tRNA ligase (EC 6.1.1.5) - Methanococcus... 978 0.0
sp|Q58050|SYL_METJA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 978 0.0
gi|11499997 leucyl-tRNA synthetase (leuS) [Archaeoglobus fulgidu... 906 0.0
sp|O27552|SYL_METTH LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 894 0.0
sp|Q9YD97|SYL_AERPE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 776 0.0
emb|CAB57710.1| (Y18930) isoleucyl-trna synthetase [Sulfolobus s... 714 0.0
gb|AAK40902.1| Leucyl-tRNA synthetase (leuS-2) [Sulfolobus solfa... 714 0.0
gb|AAK40823.1| Leucyl-tRNA synthetase (leuS-1) [Sulfolobus solfa... 563 e-159
emb|CAC11908.1| (AL445065) leucyl-tRNA synthetase related protei... 532 e-150
dbj|BAA95667.1| (D84223) leucyl tRNA synthetase [Homo sapiens] 496 e-139
dbj|BAA92590.1| (AB037773) KIAA1352 protein [Homo sapiens] 495 e-139
sp|Q09996|SYLC_CAEEL PROBABLE LEUCYL-TRNA SYNTHETASE (LEUCINE--T... 485 e-135
gb|AAB60719.1| (AC000132) Strong similarity to S. pombe leucyl-t... 469 e-131
gb|AAF51096.1| (AE003579) CG3229 gene product [Drosophila melano... 462 e-129
sp|Q10490|SYLC_SCHPO PUTATIVE LEUCYL-TRNA SYNTHETASE, CYTOPLASMI... 451 e-125
gi|6325097 cytosolic leucyl tRNA synthetase; Cdc60p [Saccharomyc... 420 e-116
gb|AAG01037.1|AF293346_1 (AF293346) cytosolic leucyl-tRNA synthe... 416 e-115
dbj|BAB14674.1| (AK023777) unnamed protein product [Homo sapiens] 403 e-111
sp|P10857|SYLC_NEUCR LEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (LEUCIN... 388 e-106
sp|Q9V072|SYI_PYRAB ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 204 4e-51
sp|O58792|SYI_PYRHO ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 203 1e-50
sp|Q58413|SYV_METJA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 185 2e-45
sp|Q9XDB4|SYI_FERPE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 171 3e-41
sp|P36430|SYL_BACSU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 171 4e-41
gb|AAK41179.1| Valyl-tRNA synthetase (valS) [Sulfolobus solfatar... 169 2e-40
gb|AAF65673.1|AF208389_1 (AF208389) isoleucyl-tRNA synthetase [M... 165 2e-39
gi|11498241 isoleucyl-tRNA synthetase (ileS) [Archaeoglobus fulg... 159 1e-37
sp|P46213|SYI_THEMA ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 157 6e-37
gb|AAF76435.1|AC015445_2 (AC015445) Contains similarity to leucy... 155 2e-36
sp|O27428|SYI_METTH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 154 4e-36
sp|Q58357|SYI_METJA ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 154 5e-36
sp|Q45477|SYI_BACSU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 152 2e-35
dbj|BAB07000.1| (AP001518) leucyl-tRNA synthetase [Bacillus halo... 151 3e-35
sp|P26499|SYI_METTM ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 145 2e-33
sp|Q9WY15|SYL_THEMA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 144 5e-33
dbj|BAB06264.1| (AP001515) isoleucyl-tRNA synthetase [Bacillus h... 143 9e-33
sp|P73274|SYL_SYNY3 LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 140 6e-32
gb|AAD36946.1|AF069441_6 (AF069441) putative leucyl tRNA synthet... 140 6e-32
pir||F81974 leucine--tRNA ligase (EC 6.1.1.4) NMA0559 [similarit... 139 1e-31
pir||G81029 leucine--tRNA ligase (EC 6.1.1.4) NMB1897 [similarit... 139 1e-31
gi|11429025 isoleucine-tRNA synthetase [Homo sapiens] >gi|730870... 139 2e-31
gi|11429023 isoleucine-tRNA synthetase [Homo sapiens] 139 2e-31
gi|4504555 isoleucine-tRNA synthetase [Homo sapiens] >gi|7770072... 137 5e-31
sp|Q9YF67|SYI_AERPE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 137 5e-31
sp|P56690|SYI_THETH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 137 7e-31
sp|P43827|SYL_HAEIN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 136 1e-30
pir||A41882 leucine--tRNA ligase (EC 6.1.1.4) - Bacillus subtili... 132 2e-29
dbj|BAB17162.1| (AP002868) putative leucyl-tRNA synthetase [Oryz... 131 3e-29
gb|AAG10490.1|AF279106_52 (AF279106) predicted leucyl-tRNA synth... 131 4e-29
sp|Q9ZDB1|SYL_RICPR LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 131 5e-29
sp|O66680|SYLA_AQUAE LEUCYL-TRNA SYNTHETASE ALPHA SUBUNIT (LEUCI... 129 2e-28
pir||D75307 leucyl-tRNA synthetase - Deinococcus radiodurans (st... 128 3e-28
pir||D72206 valine--tRNA ligase (EC 6.1.1.9) - Thermotoga mariti... 128 3e-28
pir||E83148 leucyl-tRNA synthetase PA3987 [imported] - Pseudomon... 128 3e-28
dbj|BAB06757.1| (AP001517) valyl-tRNA synthetase [Bacillus halod... 127 8e-28
gb|AAG20349.1| (AE005108) leucine-tRNA synthetase; LeuS [Halobac... 126 1e-27
pir||D71457 valine--tRNA ligase (EC 6.1.1.9) - Pyrococcus horiko... 125 2e-27
pir||G75014 valyl-tRNA synthetase (vals) PAB1255 - Pyrococcus ab... 125 2e-27
sp|P57447|SYV_BUCAI VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 124 4e-27
sp|O51680|SYV_BORBU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 124 4e-27
pir||G82260 leucyl-tRNA synthetase VC0956 [imported] - Vibrio ch... 124 4e-27
pir||E75554 valyl-tRNA synthetase - Deinococcus radiodurans (str... 122 3e-26
sp|Q9ZJ63|SYL_HELPJ LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 121 3e-26
pir||T04047 isoleucine--tRNA ligase homolog F24G24.120 - Arabido... 121 3e-26
emb|CAC11189.1| (AL445063) valyl-tRNA synthetase related protein... 120 6e-26
pir||SYBSVS valine--tRNA ligase (EC 6.1.1.9) - Bacillus stearoth... 119 1e-25
sp|P11931|SYV_BACST VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 119 1e-25
sp|P57519|SYL_BUCAI LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 118 2e-25
sp|P56457|SYL_HELPY LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 118 4e-25
sp|Q09828|SYLM_SCHPO PUTATIVE LEUCYL-TRNA SYNTHETASE, MITOCHONDR... 118 4e-25
pir||F82899 leucyl-tRNA synthetase UU371 [imported] - Ureaplasma... 117 5e-25
gb|AAB40843.1| (U82598) leucine tRNA synthetase [Escherichia coli] 116 9e-25
pir||E82590 leucyl-tRNA synthetase XF2176 [imported] - Xylella f... 116 1e-24
sp|P07813|SYL_ECOLI LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 116 1e-24
sp|O26861|SYV_METTH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 115 3e-24
emb|CAA29642.1| (X06331) leucyl-tRNA synthetase [Escherichia coli] 115 3e-24
sp|O51267|SYL_BORBU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 113 7e-24
sp|O84211|SYL_CHLTR LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 113 1e-23
sp|O67411|SYV_AQUAE VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 112 2e-23
sp|P73505|SYI_SYNY3 ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 112 2e-23
gi|11499806 valyl-tRNA synthetase (valS) [Archaeoglobus fulgidus... 112 2e-23
pir||G81698 leucyl-tRNA synthetase TC0481 [imported] - Chlamydia... 111 5e-23
sp|Q9ZCN6|SYV_RICPR VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 110 6e-23
sp|O83595|SYL_TREPA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 109 1e-22
sp|P43834|SYV_HAEIN VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 108 4e-22
sp|Q9Z930|SYL_CHLPN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 107 7e-22
sp|P36420|SYV_LACCA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 107 7e-22
sp|Q05873|SYV_BACSU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 106 1e-21
sp|O13651|SYIC_SCHPO ISOLEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (ISO... 106 1e-21
pir||G81036 isoleucyl-tRNA synthetase NMB1833 [imported] - Neiss... 105 2e-21
sp|P15181|SYLM_NEUCR LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECU... 105 3e-21
pir||B81982 probable isoleucine--tRNA ligase (EC 6.1.1.5) NMA062... 105 3e-21
pir||G83167 valyl-tRNA synthetase PA3834 [imported] - Pseudomona... 104 6e-21
emb|CAA29322.1| (X05891) valyl-tRNA synthetase [Escherichia coli] 104 6e-21
gb|AAA24657.1| (J03497) valyl tRNA synthetase [Escherichia coli] 104 6e-21
gb|AAA97155.1| (U14003) valyl-tRNA synthetase [Escherichia coli] 104 6e-21
sp|P07118|SYV_ECOLI VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 104 6e-21
sp|O84022|SYI_CHLTR ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 104 6e-21
pir||F81719 isoleucyl-tRNA synthetase TC0288 [imported] - Chlamy... 104 6e-21
pir||F81312 leucine--tRNA ligase (EC 6.1.1.4) Cj1091c [imported]... 103 8e-21
sp|Q55522|SYV_SYNY3 VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 103 8e-21
sp|O51773|SYI_BORBU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 103 8e-21
pir||T01656 leucyl-tRNA synthetase homolog K12CC - maize (fragme... 103 8e-21
gb|AAA34712.1| (M19992) isoleucyl-tRNA synthetase (EC 6.1.1.5) [... 102 2e-20
emb|CAB60428.1| (AL110500) contains similarity to Pfam domain: P... 102 2e-20
gb|AAF58412.1| (AE003819) CG4062 gene product [Drosophila melano... 100 1e-19
pir||B81309 isoleucine--tRNA ligase (EC 6.1.1.5) Cj1061c [import... 100 1e-19
sp|Q9ZHB3|SYI_STRPN ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 99 2e-19
gi|7661872 leucyl-tRNA synthetase, mitochondrial; KIAA0028 prote... 99 3e-19
pir||E82068 valyl-tRNA synthetase VC2503 [imported] - Vibrio cho... 98 4e-19
pir||E82001 valyl-tRNA synthetase NMA0094 [imported] - Neisseria... 98 5e-19
sp|P13503|SYLM_SACDO LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECU... 98 5e-19
gb|AAF47943.1| (AE003482) CG7479 gene product [Drosophila melano... 98 5e-19
pir||T27887 hypothetical protein ZK524.3 - Caenorhabditis elegan... 98 6e-19
pir||F81230 valyl-tRNA synthetase NMB0174 [imported] - Neisseria... 97 8e-19
gb|AAA35207.1| (J02719) valyl-tRNA synthetase [Saccharomyces cer... 97 8e-19
gi|6321531 mitochondrial and cytoplasmic valyl-tRNA synthetase; ... 97 8e-19
pir||T39630 valine-tRNA ligase precursor, mitochondrial - fissio... 97 1e-18
sp|P43824|SYI_HAEIN ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 97 1e-18
emb|CAB75396.1| (AL139298) valyl tRNA synthetase [Streptomyces c... 96 1e-18
dbj|BAA24690.1| (AB010832) ORF3; putative leucyl-tRNA synthase [... 96 1e-18
sp|P56456|SYI_HELPY ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 96 2e-18
sp|O66651|SYI_AQUAE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 96 2e-18
gb|AAG20602.1| (AE005130) valyl-tRNA synthetase; ValS [Halobacte... 96 2e-18
gi|6323414 mitochondrial leucyl tRNA synthetase; Nam2p [Saccharo... 95 3e-18
sp|Q9ZJJ1|SYI_HELPJ ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 95 3e-18
sp|O67646|SYLB_AQUAE LEUCYL-TRNA SYNTHETASE BETA SUBUNIT (LEUCIN... 95 4e-18
sp|Q9Z987|SYV_CHLPN VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 94 7e-18
dbj|BAB10327.1| (AB017061) isoleucyl-tRNA synthetase [Arabidopsi... 92 2e-17
pir||T51503 valine--tRNA ligase-like protein - Arabidopsis thali... 92 4e-17
sp|P47508|SYL_MYCGE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 91 5e-17
sp|P93736|SYV_ARATH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 90 8e-17
sp|P28350|SYV_NEUCR VALYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURS... 90 1e-16
gi|6319395 cytoplasmic isoleucyl-tRNA synthetase; Ils1p [Sacchar... 90 1e-16
gb|AAF51821.1| (AE003597) CG11471 gene product [alt 1] [Drosophi... 88 4e-16
gb|AAD50458.1|AF169967_1 (AF169967) LeuS [Flavobacterium johnson... 88 5e-16
pir||S77840 probable leucine--tRNA ligase (EC 6.1.1.4) - Mycopla... 87 9e-16
sp|P47576|SYV_MYCGE VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 87 9e-16
pir||H81686 valyl-tRNA synthetase TC0576 [imported] - Chlamydia ... 86 2e-15
sp|P96142|SYV_THETH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 86 2e-15
sp|Q21926|SYI_CAEEL PROBABLE ISOLEUCYL-TRNA SYNTHETASE, CYTOPLAS... 86 2e-15
sp|O84304|SYV_CHLTR VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 86 2e-15
gi|6325217 nuclear encoded mitochondrial isoleucyl-tRNA syntheta... 85 4e-15
sp|P75398|SYL_MYCPN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 85 4e-15
gb|AAA64890.1| (L38957) mitochondrial isoleucyl-tRNA synthetase ... 84 8e-15
pir||E75407 isoleucyl-tRNA synthetase - Deinococcus radiodurans ... 83 1e-14
sp|P41368|SYIP_STAAU ISOLEUCYL-TRNA SYNTHETASE, MUPIROCIN RESIST... 83 1e-14
pir||T38777 probable valyl trna synthetase - fission yeast (Sch... 82 2e-14
gb|AAF63175.1|AC010657_11 (AC010657) T5E21.11 [Arabidopsis thali... 82 2e-14
pir||T34946 probable isoleucyl-tRNA synthetase - Streptomyces co... 82 3e-14
pdb|1FFY|A Chain A, Insights Into Editing From An Ile-Trna Synth... 82 4e-14
sp|P41972|SYI_STAAU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 81 5e-14
sp|Q9ZK61|SYV_HELPJ VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 81 5e-14
sp|P56000|SYV_HELPY VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) ... 81 7e-14
pir||E82913 valyl-tRNA synthetase UU267 [imported] - Ureaplasma ... 80 1e-13
gb|AAG20324.1| (AE005106) isoleucyl-tRNA synthetase; IleS [Halob... 79 2e-13
pir||T30889 valine--tRNA ligase (EC 6.1.1.9) - Giardia lamblia >... 76 1e-12
sp|P36422|SYI_TETTH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 75 3e-12
pir||T27465 hypothetical protein Y87G2A.m - Caenorhabditis elegans 75 4e-12
sp|O33768|SYL_SULSO LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE... 75 4e-12
pir||G82894 isoleucyl-tRNA synthetase UU410 [imported] - Ureapla... 75 5e-12
sp|P41257|SYI_CAMJE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA ... 75 5e-12
pir||D82293 isoleucyl-tRNA synthetase VC0682 [imported] - Vibrio... 71 6e-11
emb|CAB66249.1| (AL136518) leucyl-tRNA synthetase. [Streptomyces... 71 8e-11
>pir||H75133 leucyl-tRNA synthetase (leus) PAB1782 - Pyrococcus abyssi (strain
Orsay) >gi|5458296|emb|CAB49785.1| (AJ248285)
leucyl-tRNA synthetase (leuS) [Pyrococcus abyssi]
Length = 967
Score = 1996 bits (5115), Expect = 0.0
Identities = 967/967 (100%), Positives = 967/967 (100%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
MPELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP
Sbjct: 1 MPELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE
Sbjct: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA
Sbjct: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN
Sbjct: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV
Sbjct: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEIT 360
TGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEIT
Sbjct: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEIT 360
Query: 361 YISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPV 420
YISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPV
Sbjct: 361 YISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPV 420
Query: 421 QEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARK 480
QEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARK
Sbjct: 421 QEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARK 480
Query: 481 ALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYT 540
ALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYT
Sbjct: 481 ALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYT 540
Query: 541 ISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEY 600
ISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEY
Sbjct: 541 ISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEY 600
Query: 601 WYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLN 660
WYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLN
Sbjct: 601 WYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLN 660
Query: 661 FIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENV 720
FIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENV
Sbjct: 661 FIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENV 720
Query: 721 ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEAKR 780
ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEAKR
Sbjct: 721 ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEAKR 780
Query: 781 FVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIK 840
FVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIK
Sbjct: 781 FVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIK 840
Query: 841 SLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHG 900
SLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHG
Sbjct: 841 SLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHG 900
Query: 901 KEVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPEEDKGGKKRQAIPL 960
KEVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPEEDKGGKKRQAIPL
Sbjct: 901 KEVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPEEDKGGKKRQAIPL 960
Query: 961 KPAVFIE 967
KPAVFIE
Sbjct: 961 KPAVFIE 967
>sp|O58698|SYL_PYRHO LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437640|pir||H71087 leucine--tRNA ligase (EC
6.1.1.4) - Pyrococcus horikoshii
>gi|3257379|dbj|BAA30062.1| (AP000004) 967aa long
hypothetical leucyl-tRNA synthetase [Pyrococcus
horikoshii]
Length = 967
Score = 1864 bits (4776), Expect = 0.0
Identities = 882/967 (91%), Positives = 934/967 (96%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
M ELNF+AIEEKWQKRWLEAK+FEPNI+DKPKEKKFYITVAFPYLSGHLHVGHARTYTIP
Sbjct: 1 MAELNFKAIEEKWQKRWLEAKIFEPNIRDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
DVIARFKRMQGYNVLFPM WHITGSPIVGIAERIKNRDP TIWIYRDVYKVPEEILWTFE
Sbjct: 61 DVIARFKRMQGYNVLFPMAWHITGSPIVGIAERIKNRDPKTIWIYRDVYKVPEEILWTFE 120
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
DP+NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQF KLKEKGYIVKGA
Sbjct: 121 DPINIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFWKLKEKGYIVKGA 180
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
HRVRWDPVVGTPLGDHDLMEGEDVPIL+Y+IIKFEL+E E IYLPAATLRPETVYGVTN
Sbjct: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILDYIIIKFELRENGEVIYLPAATLRPETVYGVTN 240
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
MW+NPNATYVKAKV+R KEETWI+SKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV
Sbjct: 241 MWVNPNATYVKAKVRRKDKEETWIVSKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEIT 360
+GDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRE+EIL KYDIDPRIVE IT
Sbjct: 301 SGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRETEILEKYDIDPRIVENIT 360
Query: 361 YISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPV 420
YISLIKLEGYG+FPAVEEV KLGIKSQKD+EKLEQATKTIYKAEYHKGIFKVPPY+GKPV
Sbjct: 361 YISLIKLEGYGDFPAVEEVNKLGIKSQKDKEKLEQATKTIYKAEYHKGIFKVPPYEGKPV 420
Query: 421 QEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARK 480
QEVKE IAKEM+EKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGN EWKEKARK
Sbjct: 421 QEVKEAIAKEMLEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNPEWKEKARK 480
Query: 481 ALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYT 540
AL RMKI PETRRAQFEAIIDWLDKKACARK+GLGTPLPWDPEWVIESLSDSTIYMAYYT
Sbjct: 481 ALERMKILPETRRAQFEAIIDWLDKKACARKIGLGTPLPWDPEWVIESLSDSTIYMAYYT 540
Query: 541 ISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEY 600
ISRHIN+LR+EG+LDPEKLTPEFFDYIFLEEFSE++EKELEKKTGIPAEIIHEMKEEFEY
Sbjct: 541 ISRHINKLRQEGKLDPEKLTPEFFDYIFLEEFSEDKEKELEKKTGIPAEIIHEMKEEFEY 600
Query: 601 WYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLN 660
WYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLN
Sbjct: 601 WYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLN 660
Query: 661 FIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENV 720
FIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLR+Q+ERFYELISQFAEYE K NV
Sbjct: 661 FIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRKQIERFYELISQFAEYEVKGNV 720
Query: 721 ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEAKR 780
ELK ID+W+LHRLNKAI+ TT ALEEFRTRTAVQWAFYSIMNDLRWY+RRTEGRDDEAKR
Sbjct: 721 ELKDIDRWMLHRLNKAIKETTNALEEFRTRTAVQWAFYSIMNDLRWYLRRTEGRDDEAKR 780
Query: 781 FVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIK 840
+VLR LAD+WVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPV+EWWNE +E EE+FI+
Sbjct: 781 YVLRTLADVWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVEEWWNETIEAEEEFIR 840
Query: 841 SLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHG 900
S++EDIKEIIEVAKIE+ KRAYIYTA +WKWKV EVV+EKR+FKS+M ELMKD EIRKHG
Sbjct: 841 SVMEDIKEIIEVAKIENAKRAYIYTAEDWKWKVAEVVSEKRDFKSSMEELMKDSEIRKHG 900
Query: 901 KEVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPEEDKGGKKRQAIPL 960
KEVAK+VQ +IKER FDVKRI+EEK LRE+K+F+EKELG+E+IINP EDKGGKK+QA+PL
Sbjct: 901 KEVAKIVQKLIKERTFDVKRINEEKALREAKEFMEKELGIEIIINPTEDKGGKKKQAMPL 960
Query: 961 KPAVFIE 967
KPA+FIE
Sbjct: 961 KPAIFIE 967
>pir||A64379 isoleucine--tRNA ligase (EC 6.1.1.5) - Methanococcus jannaschii
Length = 942
Score = 978 bits (2500), Expect = 0.0
Identities = 495/980 (50%), Positives = 678/980 (68%), Gaps = 52/980 (5%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
M ++F+ IE+KWQKRW EAK+FE N D+ +KF+IT AFPYL+G LH GH RT+TIP
Sbjct: 2 MVMIDFKEIEKKWQKRWEEAKIFEANPDDR---EKFFITAAFPYLNGVLHAGHLRTFTIP 58
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
+V+ARF+RM+ NVL+ G+H+TG+PI+G+AE IKNRD TIW Y +++ +P+E L
Sbjct: 59 EVVARFQRMKNKNVLWTFGYHVTGTPILGLAELIKNRDEKTIWAYTELHGIPKEELLELT 118
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
P IV+YF K A+E F R GFS+DW R F T F+KFIEWQF KLKEKG IVKG+
Sbjct: 119 TPEKIVEYFSKKAEEAFKRMGFSLDWRRNFKTDDKV--FNKFIEWQFHKLKEKGLIVKGS 176
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
H VR+ P P+ DHD++ GE+ ++EY++IKF ++G +P ATLRPETV+GVTN
Sbjct: 177 HPVRYCPRCDNPVEDHDILVGENATLVEYILIKFTTEDG---CIMPMATLRPETVFGVTN 233
Query: 241 MWINPNATYVKAKVKRGGKEET---------WIISKEAAYKLSFQDREIEVIEEFKGEKL 291
+W+NP ATYVKAKV + E WI++KE A KL QDR+IE+IEEFKGE+L
Sbjct: 234 VWVNPEATYVKAKVYLEKETENGIXLIENGIWIMAKECAEKLKHQDRKIEIIEEFKGEQL 293
Query: 292 IGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDI 351
I K V+NPVTG EV ILPA+FV + TG VMSVPAHAP+D++AL DL
Sbjct: 294 INKKVKNPVTGKEVPILPAKFVKTNIGTGCVMSVPAHAPYDYIALRDLG----------- 342
Query: 352 DPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFK 411
+V+EI I LI + GYG++PA E V+K+GIKSQ++ +KLE+ATK IYK E+HKG+
Sbjct: 343 ---LVDEIGLIPLINVPGYGKYPAKEIVEKMGIKSQEEEDKLEEATKKIYKDEFHKGVLN 399
Query: 412 VP--PYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDY 469
Y+G PV+E+K+ + K++++KG+AEIMYEF+E+ VI R G ++K++ QWFI Y
Sbjct: 400 ENCLDYEGIPVREIKDKLTKDLIDKGLAEIMYEFSEEKVICRCGTPCIVKMVKGQWFIKY 459
Query: 470 GNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESL 529
+ +WKE A K + +M+ PE R F IDW+ KAC R+ GLGT P++ WVIESL
Sbjct: 460 SDEKWKELAHKCIDKMRFIPENLRQVFHEKIDWMKDKACVRRRGLGTKFPFEEGWVIESL 519
Query: 530 SDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAE 589
SDSTIY AYYT++++IN + + PE+LT E FDY+FL + ++ + K+TGIP +
Sbjct: 520 SDSTIYPAYYTVAKYIN----QHNIKPEQLTLELFDYVFLGKGDVDK---IAKETGIPKD 572
Query: 590 IIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQ 649
II M++EF Y+YP+DWRCS KDLIPNHLTF+IFNHVAIF EE WP+GI VNG+ T+EG+
Sbjct: 573 IIEGMRKEFIYYYPVDWRCSAKDLIPNHLTFYIFNHVAIFPEEFWPRGIVVNGYVTIEGK 632
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
K+SKSKG VL ++ E+ GADV R YI + AE D D + KE+ ++ LER Y
Sbjct: 633 KLSKSKGPVLPVLEVAEKFGADVGRFYITTCAELPQDADIKFKEMENTKKVLERLYLFAK 692
Query: 710 QFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMR 769
+ AE + E IDKWLL RL KA++ + +E F R A Y +++DL+WY R
Sbjct: 693 EIAERRGETGEEFSYIDKWLLSRLYKAVKQYDEYMENFELRKA-GILLYQLLDDLKWYRR 751
Query: 770 RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWN 829
R VL + ++ ++LM PFTPH+CEE+WE LG EGFVSLAK+PE +E+ N
Sbjct: 752 RGGNNIR-----VLEEFLEVIIKLMMPFTPHLCEEMWEILGKEGFVSLAKFPEVKEEFIN 806
Query: 830 EEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEK--REFKSAM 887
+E+E E+++K+++EDIKEII VAK++ PKR Y+YTA +WK+++ +++ E + K M
Sbjct: 807 DEIEKGEEYLKAVMEDIKEIINVAKVQ-PKRIYLYTADDWKYEILKIIKENEGKTIKELM 865
Query: 888 AELMKDEEIRKHGKEVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPE 947
+MK+ E RK+GKE+ KLV +IK + + I+E +VL +K+FL+KE+G+E II
Sbjct: 866 PIIMKNPEFRKYGKEIPKLVNQLIK---LNAEIINEVEVLENAKEFLKKEVGVEDIIING 922
Query: 948 EDKGGKKRQAIPLKPAVFIE 967
EDK KKR AIP KPA+++E
Sbjct: 923 EDKANKKRVAIPFKPAIYLE 942
>sp|Q58050|SYL_METJA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|2826301|gb|AAB98628.1| (U67511) leucyl-tRNA
synthetase (leuS) [Methanococcus jannaschii]
Length = 942
Score = 978 bits (2500), Expect = 0.0
Identities = 495/980 (50%), Positives = 678/980 (68%), Gaps = 52/980 (5%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
M ++F+ IE+KWQKRW EAK+FE N D+ +KF+IT AFPYL+G LH GH RT+TIP
Sbjct: 2 MVMIDFKEIEKKWQKRWEEAKIFEANPDDR---EKFFITAAFPYLNGVLHAGHLRTFTIP 58
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
+V+ARF+RM+ NVL+ G+H+TG+PI+G+AE IKNRD TIW Y +++ +P+E L
Sbjct: 59 EVVARFQRMKNKNVLWTFGYHVTGTPILGLAELIKNRDEKTIWAYTELHGIPKEELLELT 118
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
P IV+YF K A+E F R GFS+DW R F T F+KFIEWQF KLKEKG IVKG+
Sbjct: 119 TPEKIVEYFSKKAEEAFKRMGFSLDWRRNFKTDDKV--FNKFIEWQFHKLKEKGLIVKGS 176
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
H VR+ P P+ DHD++ GE+ ++EY++IKF ++G +P ATLRPETV+GVTN
Sbjct: 177 HPVRYCPRCDNPVEDHDILVGENATLVEYILIKFTTEDG---CIMPMATLRPETVFGVTN 233
Query: 241 MWINPNATYVKAKVKRGGKEET---------WIISKEAAYKLSFQDREIEVIEEFKGEKL 291
+W+NP ATYVKAKV + E WI++KE A KL QDR+IE+IEEFKGE+L
Sbjct: 234 VWVNPEATYVKAKVYLEKETENGIELIENGIWIMAKECAEKLKHQDRKIEIIEEFKGEQL 293
Query: 292 IGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDI 351
I K V+NPVTG EV ILPA+FV + TG VMSVPAHAP+D++AL DL
Sbjct: 294 INKKVKNPVTGKEVPILPAKFVKTNIGTGCVMSVPAHAPYDYIALRDLG----------- 342
Query: 352 DPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFK 411
+V+EI I LI + GYG++PA E V+K+GIKSQ++ +KLE+ATK IYK E+HKG+
Sbjct: 343 ---LVDEIGLIPLINVPGYGKYPAKEIVEKMGIKSQEEEDKLEEATKKIYKDEFHKGVLN 399
Query: 412 VP--PYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDY 469
Y+G PV+E+K+ + K++++KG+AEIMYEF+E+ VI R G ++K++ QWFI Y
Sbjct: 400 ENCLDYEGIPVREIKDKLTKDLIDKGLAEIMYEFSEEKVICRCGTPCIVKMVKGQWFIKY 459
Query: 470 GNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESL 529
+ +WKE A K + +M+ PE R F IDW+ KAC R+ GLGT P++ WVIESL
Sbjct: 460 SDEKWKELAHKCIDKMRFIPENLRQVFHEKIDWMKDKACVRRRGLGTKFPFEEGWVIESL 519
Query: 530 SDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAE 589
SDSTIY AYYT++++IN + + PE+LT E FDY+FL + ++ + K+TGIP +
Sbjct: 520 SDSTIYPAYYTVAKYIN----QHNIKPEQLTLELFDYVFLGKGDVDK---IAKETGIPKD 572
Query: 590 IIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQ 649
II M++EF Y+YP+DWRCS KDLIPNHLTF+IFNHVAIF EE WP+GI VNG+ T+EG+
Sbjct: 573 IIEGMRKEFIYYYPVDWRCSAKDLIPNHLTFYIFNHVAIFPEEFWPRGIVVNGYVTIEGK 632
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
K+SKSKG VL ++ E+ GADV R YI + AE D D + KE+ ++ LER Y
Sbjct: 633 KLSKSKGPVLPVLEVAEKFGADVGRFYITTCAELPQDADIKFKEMENTKKVLERLYLFAK 692
Query: 710 QFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMR 769
+ AE + E IDKWLL RL KA++ + +E F R A Y +++DL+WY R
Sbjct: 693 EIAERRGETGEEFSYIDKWLLSRLYKAVKQYDEYMENFELRKA-GILLYQLLDDLKWYRR 751
Query: 770 RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWN 829
R VL + ++ ++LM PFTPH+CEE+WE LG EGFVSLAK+PE +E+ N
Sbjct: 752 RGGNNIR-----VLEEFLEVIIKLMMPFTPHLCEEMWEILGKEGFVSLAKFPEVKEEFIN 806
Query: 830 EEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEK--REFKSAM 887
+E+E E+++K+++EDIKEII VAK++ PKR Y+YTA +WK+++ +++ E + K M
Sbjct: 807 DEIEKGEEYLKAVMEDIKEIINVAKVQ-PKRIYLYTADDWKYEILKIIKENEGKTIKELM 865
Query: 888 AELMKDEEIRKHGKEVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPE 947
+MK+ E RK+GKE+ KLV +IK + + I+E +VL +K+FL+KE+G+E II
Sbjct: 866 PIIMKNPEFRKYGKEIPKLVNQLIK---LNAEIINEVEVLENAKEFLKKEVGVEDIIING 922
Query: 948 EDKGGKKRQAIPLKPAVFIE 967
EDK KKR AIP KPA+++E
Sbjct: 923 EDKANKKRVAIPFKPAIYLE 942
>gi|11499997 leucyl-tRNA synthetase (leuS) [Archaeoglobus fulgidus]
>gi|3122899|sp|O30250|SYL_ARCFU LEUCYL-TRNA SYNTHETASE
(LEUCINE--TRNA LIGASE) (LEURS) >gi|7437642|pir||F69552
leucyl-tRNA synthetase (leuS) homolog - Archaeoglobus
fulgidus >gi|2650668|gb|AAB91241.1| (AE001108)
leucyl-tRNA synthetase (leuS) [Archaeoglobus fulgidus]
Length = 932
Score = 906 bits (2317), Expect = 0.0
Identities = 460/964 (47%), Positives = 649/964 (66%), Gaps = 37/964 (3%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+FR IEEKWQK W + ++FE D +++KF++T+ +PYL+G+LH GH RT+TI D A
Sbjct: 3 DFRIIEEKWQKAWEKDRIFE---SDPNEKEKFFLTIPYPYLNGNLHAGHTRTFTIGDAFA 59
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
R+ RM+GYNVLFP+G+H+TG+PI+G+AE I RD TI +Y + VP E L P
Sbjct: 60 RYMRMKGYNVLFPLGFHVTGTPIIGLAELIAKRDERTIEVYTKYHDVPLEDLLQLTTPEK 119
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
IV+YF + A + G+S+DW R F TT + +FIEWQ+ KLKE G IVKG H VR
Sbjct: 120 IVEYFSREALQALKSIGYSIDWRRVFTTTD--EEYQRFIEWQYWKLKELGLIVKGTHPVR 177
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWIN 244
+ P P+ DHDL+ GE+ I+E+ +IKF L++GD + P ATLRPETV+GVTN+W+
Sbjct: 178 YCPHDQNPVEDHDLLAGEEATIVEFTVIKFRLEDGD--LIFPCATLRPETVFGVTNIWVK 235
Query: 245 PNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDE 304
P TYV A+V E W +SKEA KL++ ++++ ++EE + GKYV P+ +
Sbjct: 236 PT-TYVIAEVDG----EKWFVSKEAYEKLTYTEKKVRLLEEVDASQFFGKYVIVPLVNRK 290
Query: 305 VIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISL 364
V ILPAEFVD DNATGVVMSVPAHAPFD A+EDLKR+ E L KY ID +VE I I L
Sbjct: 291 VPILPAEFVDTDNATGVVMSVPAHAPFDLAAIEDLKRDEETLAKYGIDKSVVESIKPIVL 350
Query: 365 IKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIF--KVPPYDGKPVQE 422
IK + G PA + +++LG+KSQKD+E L++ATKT+YK EYH GI Y G V E
Sbjct: 351 IKTDIEG-VPAEKLIRELGVKSQKDKELLDKATKTLYKKEYHTGIMLDNTMNYAGMKVSE 409
Query: 423 VKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKAL 482
KE + +++++ G+ ++ YEF+EK VI R G + V+K++ DQWF++Y N EWKEK L
Sbjct: 410 AKERVHEDLVKLGLGDVFYEFSEKPVICRCGTKCVVKVVRDQWFLNYSNREWKEKVLNHL 469
Query: 483 ARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTIS 542
+M+I P+ + +F I+WL KACAR+ GLGT +PWD EW+IESLSDSTIYMAYY ++
Sbjct: 470 EKMRIIPDYYKEEFRNKIEWLRDKACARRKGLGTRIPWDKEWLIESLSDSTIYMAYYILA 529
Query: 543 RHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEYWY 602
++IN G L E +TPEF DY+ L + + E K + E+I +++++FEYWY
Sbjct: 530 KYIN----AGLLKAENMTPEFLDYVLLGKGEVGKVAEASK---LSVELIQQIRDDFEYWY 582
Query: 603 PLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLNFI 662
P+D R SGKDL+ NHL F++F+HVAIF + WP+ IAVNG+ +LEG+KMSKSKG +L
Sbjct: 583 PVDLRSSGKDLVANHLLFYLFHHVAIFPPDKWPRAIAVNGYVSLEGKKMSKSKGPLLTMK 642
Query: 663 DAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENVEL 722
A+++ GADV RLYI+ AE+DSD DW+ +EV L L RFY L+ E KE EL
Sbjct: 643 RAVQQYGADVTRLYILHAAEYDSDADWKSREVEGLANHLRRFYNLVK---ENYLKEVGEL 699
Query: 723 KTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEAKRFV 782
T+D+WL+ R+ +AI+ +A++ +TR AV AF+ +MND+RWY+RR G ++
Sbjct: 700 TTLDRWLVSRMQRAIKEVREAMDNLQTRRAVNAAFFELMNDVRWYLRR--GGEN------ 751
Query: 783 LRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSL 842
L + D W++L+APF PHICEELW L + +VSL +PE + +EE E E+++++L
Sbjct: 752 LAIILDDWIKLLAPFAPHICEELWH-LKHDSYVSLESYPEYDETRVDEEAERIEEYLRNL 810
Query: 843 IEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHGKE 902
+EDI+EI + + K YI A +WK K +VVAE + AM +LM+DEE+RK GKE
Sbjct: 811 VEDIQEIKKF--VSDAKEVYIAPAEDWKVKAAKVVAESGDVGEAMKQLMQDEELRKLGKE 868
Query: 903 VAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPEEDKGGKKRQAIPLKP 962
V+ V+ I K+R + + E +VL+++ F+E E GL+VI++ + K+RQA+P KP
Sbjct: 869 VSNFVKKIFKDRK-KLMLVKEWEVLQQNLKFIENETGLKVILDTQRVPEEKRRQAVPGKP 927
Query: 963 AVFI 966
A+++
Sbjct: 928 AIYV 931
>sp|O27552|SYL_METTH LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437646|pir||B69068 leucine--tRNA ligase (EC
6.1.1.4) - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2622626|gb|AAB85983.1| (AE000911)
leucyl-tRNA synthetase [Methanobacterium
thermoautotrophicum]
Length = 937
Score = 894 bits (2284), Expect = 0.0
Identities = 461/974 (47%), Positives = 645/974 (65%), Gaps = 54/974 (5%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE KW+ RW +A +F+ + D+ +K ++TVA+PY SG +H+GH RTYT+PDV ARFKR
Sbjct: 3 IERKWRDRWRDAGIFQADPDDR---EKIFLTVAYPYPSGAMHIGHGRTYTVPDVYARFKR 59
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
MQGYNVLFPM WH+TG+P++GIA RI+ +DP T+ IYR+V++VPE+ L F DP IV+Y
Sbjct: 60 MQGYNVLFPMAWHVTGAPVIGIARRIQRKDPWTLKIYREVHRVPEDELERFSDPEYIVEY 119
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
F + + G+S+DW REF TT P +S+FI+WQ KL++ G + KGAH V++ P
Sbjct: 120 FSREYRSVMEDMGYSIDWRREFKTTD--PTYSRFIQWQIRKLRDLGLVRKGAHPVKYCPE 177
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNAT 248
P+GDHDL+EGE V I + ++KF+L GD YL AAT RPET+YG TN+W+NP+
Sbjct: 178 CENPVGDHDLLEGEGVAINQLTLLKFKL--GDS--YLVAATFRPETIYGATNLWLNPDED 233
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIIL 308
YV +V+ GG+E WIIS+ A LS Q +++V + LIG V NPVTG E IL
Sbjct: 234 YV--RVETGGEE--WIISRAAVDNLSHQKLDLKVSGDVNPGDLIGMCVENPVTGQEHPIL 289
Query: 309 PAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLE 368
PA FVDP+ ATGVV SVPAHAP D +ALEDL+ + E+L +Y ++ +V +I +++I ++
Sbjct: 290 PASFVDPEYATGVVFSVPAHAPADFIALEDLRTDHELLERYGLED-VVADIEPVNVIAVD 348
Query: 369 GYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFK--VPPYDGKPVQEVKEL 426
GYGEFPA E ++K G+++Q+D +LE AT +YK E+ +G+ +P Y G V E +E+
Sbjct: 349 GYGEFPAAEVIEKFGVRNQED-PRLEDATGELYKIEHARGVMSSHIPVYGGMKVSEAREV 407
Query: 427 IAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALARMK 486
IA E+ ++G+A+ MYEFAE+ VI R G R V++++ DQWF+ Y + WK+ A + L MK
Sbjct: 408 IADELKDQGLADEMYEFAERPVICRCGGRCVVRVMEDQWFMKYSDDAWKDLAHRCLDGMK 467
Query: 487 IYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTISRHIN 546
I PE RA FE IDWL+ AC+R++GLGT LPWD W+IE L+DSTIYMAYYTI+ +
Sbjct: 468 IIPEEVRANFEYYIDWLNDWACSRRIGLGTRLPWDERWIIEPLTDSTIYMAYYTIA---H 524
Query: 547 RLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEYWYPLDW 606
RLRE +D ++ EFFD IFL++ + +++EEF YWYPLDW
Sbjct: 525 RLRE---MDAGEMDDEFFDAIFLDD----------------SGTFEDLREEFRYWYPLDW 565
Query: 607 RCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLNFIDAIE 666
R S KDLI NHLTF IF+H AIF E WP+G V G G LEG KMS SKGNV+ DAIE
Sbjct: 566 RLSAKDLIGNHLTFHIFHHSAIFPESGWPRGAVVFGMGLLEGNKMSSSKGNVILLRDAIE 625
Query: 667 ENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEY--------EAKE 718
++GADVVRL++MS AE DFDWR EV RR++E F E + + E
Sbjct: 626 KHGADVVRLFLMSSAEPWQDFDWRESEVIGTRRRIEWFREFGERVSGILDGRPVLSEVTP 685
Query: 719 NVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEA 778
I +W++ +LN+ I T+ALE F+TR AVQ A Y + D+ Y++R EGR D+
Sbjct: 686 AEPESFIGRWMMGQLNQRIREATRALESFQTRKAVQEALYLLKKDVDHYLKRVEGRVDDE 745
Query: 779 KRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDF 838
+ VL + W+RLMAPF P+ EE+WE+ GGEGFV+ A WP+ D+ + +V+V E+
Sbjct: 746 VKSVLANVLHAWIRLMAPFIPYTAEEMWERYGGEGFVAEAPWPDFSDDAESRDVQVAEEM 805
Query: 839 IKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAE--KREFKSAMAELMKDEEI 896
+++ + DI+EI+++ +P+R +IYT+P+WKW V V AE K + S M + E I
Sbjct: 806 VQNTVRDIQEIMKILG-STPERVHIYTSPKWKWDVLRVAAEVGKLDMGSIMGR-VSAEGI 863
Query: 897 RKHGKEVAKLVQAIIKERA-FDVKRIDEEKVLRESKDFLEKELGLEVIIN--PEEDKGGK 953
+ KEVA+ V+ II++ +V IDE VL ++ D++E E+G V+I+ P+ D K
Sbjct: 864 HDNMKEVAEFVRRIIRDLGKSEVTVIDEYSVLMDASDYIESEVGARVVIHSKPDYDPENK 923
Query: 954 KRQAIPLKPAVFIE 967
A+PLKPA+++E
Sbjct: 924 AVNAVPLKPAIYLE 937
>sp|Q9YD97|SYL_AERPE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437650|pir||H72699 probable leucyl-tRNA synthetase
APE1015 - Aeropyrum pernix (strain K1)
>gi|5104685|dbj|BAA80000.1| (AP000060) 959aa long
hypothetical leucyl-tRNA synthetase [Aeropyrum pernix]
Length = 959
Score = 776 bits (1981), Expect = 0.0
Identities = 431/980 (43%), Positives = 605/980 (60%), Gaps = 48/980 (4%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARF 66
+A+EEKWQ+RW EA++FE + +P +KF+IT +PY++ + H+G A T D++AR+
Sbjct: 5 KAVEEKWQERWREARLFEAD--PQPGRRKFFITFPYPYVNAYPHLGSAFTILRVDIMARY 62
Query: 67 KRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIV 126
KRM+GYNVLFP GWH TG PIV A R++ DP I RD+ +PEE + F DP V
Sbjct: 63 KRMRGYNVLFPQGWHATGGPIVSSALRVREGDPRIIKTLRDM-GIPEEDIPRFRDPRYWV 121
Query: 127 KYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWD 186
++F KA + R G S+DW REFYTTSL P +S+FIEWQ+LKL+EKG++ KG H V W
Sbjct: 122 EFFTKAWRRDLERYGMSIDWRREFYTTSLNPAYSRFIEWQYLKLREKGFVGKGRHPVVWC 181
Query: 187 PVVGTPLGDHDLM-EGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINP 245
P +GDHD E + E VIIKF ++G + PA T RPETV+GVTN+W++P
Sbjct: 182 PKEQKVVGDHDRPDEYAGISPQEAVIIKFRGRDG---LVYPALTYRPETVFGVTNLWVHP 238
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEV 305
+ATY+ A+V EE WII ++AA +L+ Q + ++E +G +L+G+ V NP G EV
Sbjct: 239 DATYLVAEVDG---EERWIIGEQAARELADQGHRVVILERIEGRRLLGRIVVNPADGREV 295
Query: 306 IILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLI 365
+LPA FV PD TGVVMSVPAHAP+D+VAL +LKR E L +Y ++P +VE + I LI
Sbjct: 296 PVLPASFVRPDLGTGVVMSVPAHAPYDYVALMELKRRPETLREYGLEPGVVESLEPIQLI 355
Query: 366 KLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIF--KVPPYDGKPVQEV 423
+ VEEV++ G++SQ DREKL++AT+ +Y E+++GI + G V E
Sbjct: 356 AVPRAEGLLVVEEVRRRGVESQMDREKLDEATREVYAREFYEGIMLETTGRFSGLKVAEA 415
Query: 424 KELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALA 483
KE + + + E+G A +Y ++ V R G R +KI+ DQWF+ Y EWK AR+A+A
Sbjct: 416 KEKVVEWLEERGAALRIYTLPQE-VYCRCGARTHVKIVEDQWFLLYSKPEWKALAREAVA 474
Query: 484 RMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTISR 543
RM+ P R FEAII+ L A K LGTPLPWD EWVIESLSDSTIYMAYYTI++
Sbjct: 475 RMEFLPGHVRRDFEAIIEALRDWAFTHKGELGTPLPWDREWVIESLSDSTIYMAYYTIAK 534
Query: 544 HINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEYWYP 603
+ + G ++PE LTPE FDY+FL E+ +++GIP ++ EM+ EF YWYP
Sbjct: 535 YTQHPEKYG-VEPEMLTPEVFDYVFL---GAGDPGEVSRRSGIPQGLLEEMRREFLYWYP 590
Query: 604 LDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVLNFID 663
LD R SGKDLIPNHL FFIF+H AIF E WP+ I VNG+ + G+KMSKSKGN +
Sbjct: 591 LDMRISGKDLIPNHLVFFIFHHTAIFPRELWPRAIGVNGWVLVAGEKMSKSKGNFILLRQ 650
Query: 664 AIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENV--- 720
A++ GAD R + LA DS D E + L+SQ+ ++ +EN
Sbjct: 651 ALDWWGADATR-WAEVLAGADSGLDDANFEPS----VADSAVSLLSQWLDF-VRENYGRP 704
Query: 721 ---ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDE 777
E + +D+W RLN I T+ +EE +TA+ A+Y + RWY+RR+ G E
Sbjct: 705 ARREERWVDRWFESRLNSTIARVTRLMEEANFKTALVEAWYKLQESYRWYLRRSGG---E 761
Query: 778 AKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEED 837
+ +LR+ ++ L+APF PH EE WE +G EGF S A WPEP + + EVE E+
Sbjct: 762 PREDLLRRFIEVQTLLIAPFAPHTAEEAWEAMGREGFASTASWPEPDESKISPEVEAAEE 821
Query: 838 FIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKRE----FKSAMAELMKD 893
+++++ED +E++ + I + A EWK++ E V RE K A+ E K
Sbjct: 822 TVQAVLEDAREVLSL--IGGADTLVVTVAAEWKYRAVEAVRRARERGASMKEALREAFKV 879
Query: 894 EEIRKHGKEVAKLVQAIIKERAFDV-----KRIDEEKVLRESKDFLEKELGLEVIINPEE 948
E + K +E A+LVQ + RA +V R E + LR++ L++ELG++V++ EE
Sbjct: 880 EGVDK--REAARLVQQL--SRAPEVLRRAAPRSVELEALRDAAQLLQEELGVKVVVETEE 935
Query: 949 DKGGKKR-QAIPLKPAVFIE 967
D G +R A+P +PA++ E
Sbjct: 936 DGGSPRRANALPGRPALYAE 955
>emb|CAB57710.1| (Y18930) isoleucyl-trna synthetase [Sulfolobus solfataricus]
Length = 944
Score = 714 bits (1824), Expect = 0.0
Identities = 402/986 (40%), Positives = 574/986 (57%), Gaps = 72/986 (7%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
I KWQ RW E K++E N P + KF+ TVAFPY + H+GH RTY D++AR+KR
Sbjct: 4 IAYKWQTRWEEDKIYESN--PNPSKPKFFTTVAFPYPNSPWHIGHGRTYVTGDILARYKR 61
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M+GYNVLFPM +H TG+PI+ +A+ I D I ++D+Y++ +++ DP+ + Y
Sbjct: 62 MRGYNVLFPMAFHYTGTPIMAMADAIAKGDKELIETFKDIYEISPDVIPRMSDPLFMANY 121
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
F + K + G +DW REF T++ P FS F+ WQF KL+ KGYIVK H V W PV
Sbjct: 122 FKEDIKASMREIGLGIDWRREF--TTIDPEFSSFVTWQFHKLQSKGYIVKDTHPVGWCPV 179
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNAT 248
P+G HD + I E+V+I F ++G PAATLRPET++G T +WINP+
Sbjct: 180 HHIPVGMHDTKGDVEPEIGEFVLIYFNSEKG----IFPAATLRPETIFGATALWINPSEM 235
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIIL 308
YV A + GK+ I+S++AA KLSFQ +IE+ E+ KG KL+G V NP+TG + +L
Sbjct: 236 YVVASML--GKK--MILSEKAAAKLSFQIDDIEIEEKIKGSKLVGLKVENPITGKHIAVL 291
Query: 309 PAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLE 368
A+FVD TGVVMSVPAHAPFD+ + + + I + I +I +E
Sbjct: 292 GADFVDVSLGTGVVMSVPAHAPFDYYYSKKTFKNNNIEI--------------IPVITVE 337
Query: 369 GYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFK--------------VPP 414
G G A + V+K KS +D +KL T+ +Y+ EY+KG+ + +
Sbjct: 338 GLGNALAKDVVEKNNPKSDEDLKKL---TEYVYRTEYNKGVLRSDLGNLIREEYRNELKS 394
Query: 415 YDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEW 474
G PV + +ELI ++ KG+ ++E K V R G V+KI+ DQWF+DY N EW
Sbjct: 395 LGGLPVPKGRELITNFLISKGLGRKIFEVMNKPVYCRCGTEIVVKILKDQWFLDYSNKEW 454
Query: 475 KEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTI 534
KE ARK+L+++ + PE R FE I+WL+K+ACAR GLGTPLPWD +W+IESLSDSTI
Sbjct: 455 KELARKSLSKINVIPEESRKDFEFTIEWLEKRACARTRGLGTPLPWDKKWIIESLSDSTI 514
Query: 535 YMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEM 594
YMAYYTIS I ++ +L P KLT EF+DY+ L + E E+ +KTGIP+ II E
Sbjct: 515 YMAYYTISHKI----KQYKLSPSKLTQEFWDYVMLGIGNLE---EISEKTGIPSNIIKEF 567
Query: 595 KEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKS 654
+EEF YWYPLD R SGKDLIPNHLTFFIFNH AIF+E WPK IAVNG EG+KMSKS
Sbjct: 568 REEFLYWYPLDIRHSGKDLIPNHLTFFIFNHAAIFQENLWPKAIAVNGLVLYEGKKMSKS 627
Query: 655 KGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEY 714
N++ ++ G DV+R+ + S A+ SD ++ V + L + YEL Y
Sbjct: 628 LRNIIPLRKGLKMYGVDVMRIAVSSTADMGSDVNFSESLVKTVGETLRKMYELFKSLDNY 687
Query: 715 EAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGR 774
L +KWLL R+ + TT+ +E R AV + +DL Y
Sbjct: 688 TGD---ILGFPEKWLLSRIYEITSSTTRHMEALELRDAVNELLFVFSSDLDEYFGMVSAE 744
Query: 775 DDEAKRFVLRKLADIWVRLMAPFTPHICEELW-EKLGGEGFVSLAKWPEPVDEWWNEEVE 833
EA VLR++ IW++L+ PF PH+ EE+W E L + ++ WPE +E
Sbjct: 745 GREANNKVLREVLTIWLKLITPFAPHLAEEIWHEILKQKTYIVNEGWPEVEGSKMDELTL 804
Query: 834 VEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKD 893
+E +++K ++EDI+ I+ + K +PK IY + ++ + R+ A ++ K
Sbjct: 805 LEHEYMKRIVEDIRSILNIFK-GTPKLIKIYALNDSRY-----MELLRDAIVANGQMKKF 858
Query: 894 EEIRK-HGKEVAKLVQAIIKER-AFDVK--------RIDEEKVLRESKDFLEKELGLEVI 943
+I K +E A+++Q I E D K I+E VL + ++ ++L ++++
Sbjct: 859 MDIHKPKSREDARILQKIFNESLEIDDKMKKLVTNYNINEVDVLNKLSKYIRRKLNVDIL 918
Query: 944 INP--EEDKGGKKRQAIPLKPAVFIE 967
I P EE K ++A+PL+PA+ IE
Sbjct: 919 IEPYDEEVKKTYNKEAMPLRPAIIIE 944
>gb|AAK40902.1| Leucyl-tRNA synthetase (leuS-2) [Sulfolobus solfataricus]
Length = 944
Score = 714 bits (1824), Expect = 0.0
Identities = 402/986 (40%), Positives = 574/986 (57%), Gaps = 72/986 (7%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
I KWQ RW E K++E N P + KF+ TVAFPY + H+GH RTY D++AR+KR
Sbjct: 4 IAYKWQTRWEEDKIYESN--PNPSKPKFFTTVAFPYPNSPWHIGHGRTYVTGDILARYKR 61
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M+GYNVLFPM +H TG+PI+ +A+ I D I ++D+Y++ +++ DP+ + Y
Sbjct: 62 MRGYNVLFPMAFHYTGTPIMAMADAIAKGDKELIETFKDIYEISPDVIPRMSDPLFMANY 121
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
F + K + G +DW REF T++ P FS F+ WQF KL+ KGYIVK H V W PV
Sbjct: 122 FKEDIKASMREIGLGIDWRREF--TTIDPEFSSFVTWQFHKLQSKGYIVKDTHPVGWCPV 179
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNAT 248
P+G HD + I E+V+I F ++G PAATLRPET++G T +WINP+
Sbjct: 180 HHIPVGMHDTKGDVEPEIGEFVLIYFNSEKG----IFPAATLRPETIFGATALWINPSEM 235
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIIL 308
YV A + GK+ I+S++AA KLSFQ +IE+ E+ KG KL+G V NP+TG + +L
Sbjct: 236 YVVASML--GKK--MILSEKAAAKLSFQIDDIEIEEKIKGSKLVGLKVENPITGKHIAVL 291
Query: 309 PAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLE 368
A+FVD TGVVMSVPAHAPFD+ + + + I + I +I +E
Sbjct: 292 GADFVDVSLGTGVVMSVPAHAPFDYYYSKKTFKNNNIEI--------------IPVITVE 337
Query: 369 GYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFK--------------VPP 414
G G A + V+K KS +D +KL T+ +Y+ EY+KG+ + +
Sbjct: 338 GLGNALAKDVVEKNNPKSDEDLKKL---TEYVYRTEYNKGVLRSDLGNLIREEYRNELKS 394
Query: 415 YDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEW 474
G PV + +ELI ++ KG+ ++E K V R G V+KI+ DQWF+DY N EW
Sbjct: 395 LGGLPVPKGRELITNFLISKGLGRKIFEVMNKPVYCRCGTEIVVKILKDQWFLDYSNKEW 454
Query: 475 KEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTI 534
KE ARK+L+++ + PE R FE I+WL+K+ACAR GLGTPLPWD +W+IESLSDSTI
Sbjct: 455 KELARKSLSKINVIPEESRKDFEFTIEWLEKRACARTRGLGTPLPWDKKWIIESLSDSTI 514
Query: 535 YMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEM 594
YMAYYTIS I ++ +L P KLT EF+DY+ L + E E+ +KTGIP+ II E
Sbjct: 515 YMAYYTISHKI----KQYKLSPSKLTQEFWDYVMLGIGNLE---EISEKTGIPSNIIKEF 567
Query: 595 KEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKS 654
+EEF YWYPLD R SGKDLIPNHLTFFIFNH AIF+E WPK IAVNG EG+KMSKS
Sbjct: 568 REEFLYWYPLDIRHSGKDLIPNHLTFFIFNHAAIFQENLWPKAIAVNGLVLYEGKKMSKS 627
Query: 655 KGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEY 714
N++ ++ G DV+R+ + S A+ SD ++ V + L + YEL Y
Sbjct: 628 LRNIIPLRKGLKMYGVDVMRIAVSSTADMGSDVNFSESLVKTVGETLRKMYELFKSLDNY 687
Query: 715 EAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGR 774
L +KWLL R+ + TT+ +E R AV + +DL Y
Sbjct: 688 TGD---ILGFPEKWLLSRIYEITSSTTRHMEALELRDAVNELLFVFSSDLDEYFGMVSAE 744
Query: 775 DDEAKRFVLRKLADIWVRLMAPFTPHICEELW-EKLGGEGFVSLAKWPEPVDEWWNEEVE 833
EA VLR++ IW++L+ PF PH+ EE+W E L + ++ WPE +E
Sbjct: 745 GREANNKVLREVLTIWLKLITPFAPHLAEEIWHEILKQKTYIVNEGWPEVEGSKMDELTL 804
Query: 834 VEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKD 893
+E +++K ++EDI+ I+ + K +PK IY + ++ + R+ A ++ K
Sbjct: 805 LEHEYMKRIVEDIRSILNIFK-GTPKLIKIYALNDSRY-----MELLRDAIVANGQMKKF 858
Query: 894 EEIRK-HGKEVAKLVQAIIKER-AFDVK--------RIDEEKVLRESKDFLEKELGLEVI 943
+I K +E A+++Q I E D K I+E VL + ++ ++L ++++
Sbjct: 859 MDIHKPKSREDARILQKIFNESLEIDDKMKKLVTNYNINEVDVLNKLSKYIRRKLNVDIL 918
Query: 944 INP--EEDKGGKKRQAIPLKPAVFIE 967
I P EE K ++A+PL+PA+ IE
Sbjct: 919 IEPYDEEVKKTYNKEAMPLRPAIIIE 944
>gb|AAK40823.1| Leucyl-tRNA synthetase (leuS-1) [Sulfolobus solfataricus]
Length = 934
Score = 563 bits (1436), Expect = e-159
Identities = 348/990 (35%), Positives = 530/990 (53%), Gaps = 89/990 (8%)
Query: 6 FRAIEEKWQKRWLEAKVFEPNIK-DKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
F +I KWQ W ++KVFE N+ KPK F+ITV FPY + +HVGH RTY D+ A
Sbjct: 6 FNSIAFKWQAEWEKSKVFETNMDYSKPK---FFITVPFPYTNSPMHVGHGRTYITADIYA 62
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
R+ RM+GYNVLFP + TG+P++ IA+ I+ + I +++VY+VP++ + EDP
Sbjct: 63 RYLRMKGYNVLFPFAFQFTGTPVLAIADSIRRGEVDVIEFFKNVYEVPQDKIKELEDPYK 122
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
+ +YF + K T G S+DW R F TT P F KFI WQ KLKE GY+V V
Sbjct: 123 LAEYFKEEMKNTAKSIGMSIDWRRTFTTTD--PRFEKFIHWQLGKLKELGYLVTEDDVVG 180
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWIN 244
+ P G P+G HD + I +I F EG ++ AT RPE ++GV + +N
Sbjct: 181 YCPNDGFPVGMHDTRGDIEPEITTMNVIMF---EGSDSYNFMVATSRPELIFGVVALMVN 237
Query: 245 PNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDE 304
+A YV V+ GK +IIS++A KLSFQ + +++++ ++ Y NP+TG +
Sbjct: 238 HDANYV--VVEYEGK--NFIISEKAYKKLSFQ-KNMKLVKTITTSDIVKLYAINPITGRK 292
Query: 305 VIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISL 364
+ I+ ++VDP TGVVMS PAH PF ++A+ + +E E+ I +
Sbjct: 293 LEIIKNKYVDPSLGTGVVMSYPAHDPFHYLAMTETNKEFEV----------------IPV 336
Query: 365 IKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFK------VPPY--- 415
++ E E P + + K+ L+ ++IYK EY+KG K VP +
Sbjct: 337 VETEELDEIPG-----ESAVLQTKNPYALKDFMESIYKTEYYKGYMKDIILSLVPDFLKQ 391
Query: 416 ------DGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDY 469
GK VQE ++ + + I + +YE + + R G+ V K I DQWFI Y
Sbjct: 392 YVKENIVGKQVQEARKNTIELLKSLNIYDTIYEISNGPIYCRCGSEIVPKRIKDQWFIAY 451
Query: 470 GNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESL 529
N +WK A KA+ +++ P + + E I+ K+ R G+G LPWD ++ESL
Sbjct: 452 DNPKWKASALKAINNIELIPNPTKTELEKIVFNARKEPIGRSRGIGVKLPWDESQIVESL 511
Query: 530 SDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAE 589
SDST+Y YT+ + P + E FD+IFL + KELE+K G
Sbjct: 512 SDSTLYTLLYTVIYKM----------PINIEKEIFDFIFL---GKGDAKELERKYGTD-- 556
Query: 590 IIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQ 649
+ +++EEF YWYP+D R +G+DLI NH+ F+I+NH+AIF E++ PK I +NGF + G+
Sbjct: 557 -LIQLREEFLYWYPVDQRHTGRDLIQNHIPFYIYNHLAIFGEKYLPKRIVINGFVRVGGR 615
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKS N+ AI+E G D VR+ + S ++ D D+ V + QL++ Y+LI
Sbjct: 616 KMSKSLRNIYTLSKAIKEFGVDPVRIALTSTSDLLQDLDFNENLVNPIAEQLKKIYDLID 675
Query: 710 QFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMR 769
+ E EL+T D+W+ ++ IE + F+ R AV Y I LR Y
Sbjct: 676 RLLSINT-EIKELRTADEWISSKVRDIIEKVNNNITSFKYRDAVNLLLYEIYEILRDYFD 734
Query: 770 RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWN 829
E + E V+RK+ IW+R +APF PHI EELW K+ FVSL K+PEP +
Sbjct: 735 LVEIPNQE----VIRKILSIWIRALAPFVPHIAEELWHKISST-FVSLEKYPEPNELNLY 789
Query: 830 EEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAE 889
+ +E +I +IE+++E+ ++ ++ K E KV E++ K K+ E
Sbjct: 790 PDAILEISYINKIIENVRELEDIVHKKAEKVIIYINESE---KVKELM--KNAIKAVNEE 844
Query: 890 LMKDEEIRKHGKEVAKLVQAIIKERAFDVK------RIDEEKVLRESKDFLEKELGLE-- 941
+ E ++A+ V ++ + ++ IDEE+++ ++ +FL + LG+
Sbjct: 845 IPLREFTANTEDKIAEKVYVVVSKLDKAIRDYLLNNEIDEEQIIVKNMNFLLRRLGVSEI 904
Query: 942 VIINPEE----DKGGKKRQAIPLKPAVFIE 967
VI N E+ D GKK QA+PL PA+ +E
Sbjct: 905 VIYNAEDPTVPDVKGKKSQALPLSPAIVVE 934
>emb|CAC11908.1| (AL445065) leucyl-tRNA synthetase related protein [Thermoplasma
acidophilum]
Length = 910
Score = 532 bits (1355), Expect = e-150
Identities = 321/977 (32%), Positives = 519/977 (52%), Gaps = 105/977 (10%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE KWQ W +F P + + KKF ITV +PY +G LHVGH RTYT+ D+IAR+KR
Sbjct: 19 IEAKWQNAWDRDGIFVPKMDGR---KKFMITVPWPYTNGSLHVGHGRTYTLGDIIARYKR 75
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEE-----ILWTFEDPV 123
+ YNVLFPMG+H +G+PI+ +ERI+ D TI +Y K E ++ +F+DP
Sbjct: 76 SRNYNVLFPMGFHQSGTPILAFSERIRAGDRSTIDLYTSYLKEYGEKDIDALIESFKDPK 135
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
NI YF A F G+S+DW+R F + F + KF++WQF +L EKG + +G + +
Sbjct: 136 NIADYFSNAIINDFKHLGYSIDWTRRFTSADEF--YQKFVQWQFRRLNEKGLVKQGRYPI 193
Query: 184 RWDPVVGTPLGDHDLMEG--EDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNM 241
+ +G+ D+ +G + V I EY I F K D L AA+LRPET+YG+TN+
Sbjct: 194 LYSLEDDNAVGEDDIKDGDTDKVTIEEYTAIFFRGKSFD----LIAASLRPETIYGITNI 249
Query: 242 WINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVT 301
W+NP+ YVK K+ ++S+E + KL FQ EIEV E ++ I K
Sbjct: 250 WVNPDVKYVKVKI----SGRMAVVSEECSTKLKFQGNEIEVAGEASVQE-IQKQTYTTPA 304
Query: 302 GDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLK-RESEILVKYDIDPRIVEEIT 360
G EV + A+FVDPDN TG+V SVP+H+ +D+V + ++ ++++ + + +E
Sbjct: 305 GKEVKVYQADFVDPDNGTGIVYSVPSHSVYDYVYYRKKRGKDFPVIIEAPMKMKDIE--- 361
Query: 361 YISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKG-IFKVPPYDGKP 419
K +++++ R E+ATK +Y+ E++ G + PY G
Sbjct: 362 -------------------SKYDLETEEGR---EEATKDLYRNEFYYGKLVDSGPYTGMT 399
Query: 420 VQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKAR 479
V+E +E + ++++ G A YE ++ ++R G++ ++ ++ DQWF+DY K+
Sbjct: 400 VREAREAVKRDLISSGNAFTFYE-TSRHAVTRSGSKVIVAVLPDQWFLDYSQPWLKDLGH 458
Query: 480 KALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYY 539
+ M ++PE R IDWL ++ CAR+ GLGT LP+D WVIESLSDSTIY A Y
Sbjct: 459 TMINTMTMHPEVYRNVMNDAIDWLKERPCARRRGLGTRLPFDDRWVIESLSDSTIYPAVY 518
Query: 540 TISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFE 599
T S + L E G+LD + +T F + E + E E E K +FE
Sbjct: 519 TNSIPLRSLYETGKLDDDAITRIF--------MNGEPKNEDES----------EAKRQFE 560
Query: 600 YWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGNVL 659
YWYP+D R + I NHL+F++ NH AIF +E WP G+ ++G G K+SKSKGNV+
Sbjct: 561 YWYPVDIRLTAIPHISNHLSFYVLNHAAIFPKEKWPAGLIISGLVVSNGAKISKSKGNVV 620
Query: 660 NFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKEN 719
+ ++ ++ AD+ RLY+ A+ S DW ++ + R+ F +L++ F + +
Sbjct: 621 SLLEIAKKYSADIYRLYVAVQADISSTMDWNETDLASITRRFNEFKDLMAGFKQ----DT 676
Query: 720 VELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEAK 779
+L + W + R + + ++++ ++ R A FY ++NDLR+ R +
Sbjct: 677 SDLTFEEAWFVARFSVRLRQFMESMDRYQIRDAYINIFYGVLNDLRY----LSSRGGDVN 732
Query: 780 RFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWN---------- 829
R + +AD W+R + P PH EE W + +VS+ + E + +
Sbjct: 733 RALTPVIAD-WLRALMPVIPHHAEEYWHSYVSDTYVSVDPFDENFQDRYERTVRRFGMTC 791
Query: 830 EEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAE 889
+++ D+++ +++D+K I++V IE PK I A +VV +EF +
Sbjct: 792 DQMYSAMDYVEKVLQDVKNIMQVTGIE-PKSVEITVANA------DVVRAAQEFLNNSV- 843
Query: 890 LMKDEEIRKHGKEVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPEED 949
+ +K+ + +AK + + + DE VL+ ++ +L K++G V I +
Sbjct: 844 ---SGQSKKYMQYLAK------RRKDIMIYGFDEYDVLQRNQVYLSKQIGCPVRIERGDV 894
Query: 950 KGGKKRQAIPLKPAVFI 966
GK A+P KP ++I
Sbjct: 895 INGK--IALPGKPVIYI 909
>dbj|BAA95667.1| (D84223) leucyl tRNA synthetase [Homo sapiens]
Length = 1176
Score = 496 bits (1264), Expect = e-139
Identities = 338/1076 (31%), Positives = 535/1076 (49%), Gaps = 136/1076 (12%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEK---KFYITVAFPYLSGHLHVGHARTYTIPDVI 63
+ IE++ Q++W +VFE N + K+ K+++T +PY++G LH+GH + + +
Sbjct: 14 KKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFA 73
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNR-------------------------- 97
++R++G LFP G H TG PI A+++K
Sbjct: 74 VGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTED 133
Query: 98 --------------------DPHTIWIYRDVYKVPEEILWTFEDPVNIVKYFMKAAKETF 137
+ I + + EEI+ F + + + YF A +
Sbjct: 134 IIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIV-KFSEAEHWLDYFPPLAIQDL 192
Query: 138 IRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHD 197
R G VDW R F TT + P + F+ WQFL L+E+ I G + P G P DHD
Sbjct: 193 KRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHD 252
Query: 198 LMEGEDVPILEYVIIKFELKE---------GDETIYLPAATLRPETVYGVTNMWINPNAT 248
GE V EY ++K + E + I+L AATLRPET++G TN W+ P+
Sbjct: 253 RQTGEGVGPQEYTLLKLKALEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMK 312
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQ-----DREIEVIEEFKGEKLIGKYVRNPVTGD 303
Y+ + G + +I +++AA +S+Q + + V++E GE+++G + P+T
Sbjct: 313 YIGFETVNG---DIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSY 369
Query: 304 EVI-ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYI 362
+VI +LP + D TGVV SVP+ +P D AL DLK++ + KY I +V +
Sbjct: 370 KVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPV 429
Query: 363 SLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQE 422
+I++ G+G AV +L I+SQ DREKL +A + IY +++GI V + G+ VQ+
Sbjct: 430 PVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQD 489
Query: 423 VKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKAL 482
VK+ I K+M++ G A ++Y EK V+SR + V+ + DQW++DYG WK++ + L
Sbjct: 490 VKKTIQKKMIDAGDA-LIYMEPEKQVMSRSSDECVVALC-DQWYLDYGEENWKKQTSQCL 547
Query: 483 ARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTIS 542
++ + E R FEA + WL + AC+R GLGT LPWD +W+IESLSDSTIYMA+YT++
Sbjct: 548 KNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVA 607
Query: 543 RHINRLREEGRLD------PEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKE 596
+ G+ + P+++T E +DY+F +E KT I E + ++K+
Sbjct: 608 HLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAP-------FPKTQIAKEKLDQLKQ 660
Query: 597 EFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFRE--EHWPKGIAVNGFGTLEGQKMSKS 654
EFE+WYP+D R SGKDL+PNHL+++++NHVA++ E + WP + NG L +KMSKS
Sbjct: 661 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS 720
Query: 655 KGNVLNFIDAIEENGADVVRLYIMSLAE--HDSDFDWRRKEVGKLRRQLERFYELISQF- 711
GN L AI++ AD +RL + + D++F + G LR L + E + +
Sbjct: 721 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILR--LYTWVEWVKEMV 778
Query: 712 AEYEAKENVELKTI-DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMR- 769
A +++ + T D+ LN I T + E+ + A++ F+ Y
Sbjct: 779 ANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYREL 838
Query: 770 RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP--EPVDEW 827
EG E ++ + ++ L+APF PH+CE +W LG + A WP PVDE
Sbjct: 839 AVEGMHRE----LVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVDEV 894
Query: 828 WNEEVEVEEDFIKSLIEDIKEIIEVAK--------IESPKRAYIYTA---PEWKWKVYEV 876
+ + L +K + AK ++ P IY A P W+ V
Sbjct: 895 LIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSV 954
Query: 877 VAEKREF--------KSAMAELMKDEEIRKHGKEVAKLVQAIIKE-------RAFDVK-R 920
+ + E K +EL E++K+ K+V V A+IKE R D++
Sbjct: 955 LRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFV-AMIKENLEKMGPRILDLQLE 1013
Query: 921 IDEEKVLRESKDFLEKELGLEVI----INPEEDK------GGKKRQAIPLKPAVFI 966
DE+ VL E+ +L L LE I + EDK GK ++P V +
Sbjct: 1014 FDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSV 1069
>dbj|BAA92590.1| (AB037773) KIAA1352 protein [Homo sapiens]
Length = 1212
Score = 495 bits (1261), Expect = e-139
Identities = 337/1076 (31%), Positives = 536/1076 (49%), Gaps = 136/1076 (12%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEK---KFYITVAFPYLSGHLHVGHARTYTIPDVI 63
+ IE++ Q++W +VFE N + K+ K+++T +PY++G LH+GH + + +
Sbjct: 50 KKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFA 109
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNR-------------------------- 97
++R++G LFP G H TG PI A+++K
Sbjct: 110 VGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTED 169
Query: 98 --------------------DPHTIWIYRDVYKVPEEILWTFEDPVNIVKYFMKAAKETF 137
+ I + + EEI+ F + + + YF A +
Sbjct: 170 IIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIV-KFSEAEHWLDYFPPLAIQDL 228
Query: 138 IRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHD 197
R G VDW R F TT + P + F+ WQFL L+E+ I G + P G P DHD
Sbjct: 229 KRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHD 288
Query: 198 LMEGEDVPILEYVIIKFELKE---------GDETIYLPAATLRPETVYGVTNMWINPNAT 248
GE V EY ++K ++ E + I+L AATLRPET++G TN W+ P+
Sbjct: 289 RQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMK 348
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQ-----DREIEVIEEFKGEKLIGKYVRNPVTGD 303
Y+ + G + +I +++AA +S+Q + + V++E GE+++G + P+T
Sbjct: 349 YIGFETVNG---DIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSY 405
Query: 304 EVI-ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYI 362
+VI +LP + D TGVV SVP+ +P D AL DLK++ + KY I +V +
Sbjct: 406 KVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPV 465
Query: 363 SLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQE 422
+I++ G+G AV +L I+SQ DREKL +A + IY +++GI V + G+ VQ+
Sbjct: 466 PVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQD 525
Query: 423 VKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKAL 482
VK+ I K+M++ G A ++Y EK V+SR + V+ + DQW++DYG WK++ + L
Sbjct: 526 VKKTIQKKMIDAGDA-LIYMEPEKQVMSRSSDECVVALC-DQWYLDYGEENWKKQTSQCL 583
Query: 483 ARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTIS 542
++ + E R FEA + WL + AC+R GLGT LPWD +W+IESLSDSTIYMA+YT++
Sbjct: 584 KNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVA 643
Query: 543 RHINRLREEGRLD------PEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKE 596
+ G+ + P+++T E +DY+F +E KT I E + ++K+
Sbjct: 644 HLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAP-------FPKTQIAKEKLDQLKQ 696
Query: 597 EFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFRE--EHWPKGIAVNGFGTLEGQKMSKS 654
EFE+WYP+D R SGKDL+PNHL+++++NHVA++ E + WP + NG L +KMSKS
Sbjct: 697 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS 756
Query: 655 KGNVLNFIDAIEENGADVVRLYIMSLAE--HDSDFDWRRKEVGKLRRQLERFYELISQF- 711
GN L AI++ AD +RL + + D++F + G LR L + E + +
Sbjct: 757 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILR--LYTWVEWVKEMV 814
Query: 712 AEYEAKENVELKTI-DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMR- 769
A +++ + T D+ LN I T + E+ + A++ F+ Y
Sbjct: 815 ANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYREL 874
Query: 770 RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP--EPVDEW 827
EG E ++ + ++ L+APF PH+CE +W LG + A WP PV+E
Sbjct: 875 AVEGMHRE----LVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEV 930
Query: 828 WNEEVEVEEDFIKSLIEDIKEIIEVAK--------IESPKRAYIYTA---PEWKWKVYEV 876
+ + L +K + AK ++ P IY A P W+ V
Sbjct: 931 LIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSV 990
Query: 877 VAEKREF--------KSAMAELMKDEEIRKHGKEVAKLVQAIIKE-------RAFDVK-R 920
+ + E K +EL E++K+ K+V V A+IKE R D++
Sbjct: 991 LRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFV-AMIKENLEKMGPRILDLQLE 1049
Query: 921 IDEEKVLRESKDFLEKELGLEVI----INPEEDK------GGKKRQAIPLKPAVFI 966
DE+ VL E+ +L L LE I + EDK GK ++P V +
Sbjct: 1050 FDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSV 1105
>sp|Q09996|SYLC_CAEEL PROBABLE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7506790|pir||T19334 hypothetical protein R74.1 -
Caenorhabditis elegans >gi|3874391|emb|CAA86751.1|
(Z46787) contains similarity to Pfam domain: PF00133
(tRNA synthetases class I (I, L, M and V)), Score=-200.6,
E-value=2e-07, N=1~cDNA EST yk47d5.3 comes from this
gene; cDNA EST yk130d10.3 comes from this gene~cDNA EST
yk130d10.5 comes from this gene;>
>gi|3879166|emb|CAA85280.1| (Z36238) contains similarity
to Pfam domain: PF00133 (tRNA synthetases class I (I, L,
M and V)), Score=-200.6, E-value=2e-07, N=1~cDNA EST
yk47d5.3 comes from this gene; cDNA EST yk130d10.3 comes
from this gene~cDNA EST yk130d10.5 comes from this gene;>
Length = 1186
Score = 485 bits (1235), Expect = e-135
Identities = 330/1055 (31%), Positives = 523/1055 (49%), Gaps = 133/1055 (12%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE+ Q+ W K FE + +D K K + +T FPY++G LH+GH + + + A F+R
Sbjct: 17 IEKSIQELWESKKAFEADARDDGKPK-YLVTFPFPYMNGRLHLGHTFSASKCEFAAGFQR 75
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIK----------NRDPHTIWIYRDVYKVPEEIL-- 116
+QG VLFP G+H TG PI A+++K N + ++ +EI+
Sbjct: 76 LQGKEVLFPFGFHCTGMPIKACADKLKREMQDFGYPPNFPEDVVEEVKEEVSAVDEIIKD 135
Query: 117 -------------------WT--------------FEDPVNIVKYFMKAAKETFIRAGFS 143
W F DP + + YF + G
Sbjct: 136 KSKGKKSKLVAKTGNAKYQWQIMKSLGLCDEEIKEFSDPNHWLYYFPPHCIADLKKMGLK 195
Query: 144 VDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGED 203
DW R F TT + P F F+ WQF L+ I G + P G P DHD GE
Sbjct: 196 ADWRRSFITTDVNPYFDSFVRWQFNLLRAAKKIDFGKRYTIYSPKDGQPCMDHDRASGEG 255
Query: 204 VPILEYVIIKFE--------LKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVK 255
V EY +IK + L E IYL AATLRPET+YG TN +++P+ Y
Sbjct: 256 VGPQEYTLIKLKVLDPKPQALSHIKEDIYLVAATLRPETMYGQTNCYLHPDIQYSVFYAT 315
Query: 256 RGGKEETWIISKEAAYKLSFQDREIEV--------IEEFKGEKLIGKYVRNPVTGDE-VI 306
K+ ++ + +A +S+Q E +E+ G K++G + P+ E V
Sbjct: 316 ENEKQ-VFVATARSARIMSYQGLTKENGKVNYVLGLEKIAGSKILGAPLSAPLAKYERVY 374
Query: 307 ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIK 366
LP + D TGVV SVP+ +P D AL DLK++ + KY + +V + +IK
Sbjct: 375 ALPMLTIKDDKGTGVVTSVPSDSPDDFAALSDLKKKKPLREKYGLTDEMVLPFEPVPIIK 434
Query: 367 LEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQEVKEL 426
+EG G+ AVE +L I+SQ +++KLE+A K +Y ++ G+ V Y GK +VK++
Sbjct: 435 IEGLGDLAAVEMCSRLKIESQNEKDKLEEAKKEVYLKGFYDGVMLVGKYAGKKTADVKKV 494
Query: 427 IAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALARMK 486
I ++ +G+A Y EK V+SR G+ V+ + DQW+++YG +EWK A+K L ++
Sbjct: 495 IQDDLTAEGLAT-KYVEPEKKVMSRSGDECVVALC-DQWYLNYGEAEWKAAAKKVLEPLR 552
Query: 487 IYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTISRHIN 546
+ + R E +DWL + AC+R GLGT LPWD +++IESLSDSTIY AYYT++ +
Sbjct: 553 TFNDETRRGLETTVDWLHEYACSRSYGLGTKLPWDTQYLIESLSDSTIYNAYYTVAHLLQ 612
Query: 547 RLREEGR------LDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEY 600
+ +G + +++T + Y+FL E + + +E+ E + +++EF Y
Sbjct: 613 QGAFDGSVVGPAGIKADQMTDASWSYVFLGEIYDSKTMPVEE------EKLKSLRKEFMY 666
Query: 601 WYPLDWRCSGKDLIPNHLTFFIFNHVAIFREE--HWPKGIAVNGFGTLEGQKMSKSKGNV 658
WYP+D R SGKDLI NHLT+ +FNH AI+ + WPKGI NG L +KMSKS GN
Sbjct: 667 WYPIDMRASGKDLIGNHLTYLLFNHAAIWPTDTSKWPKGIRANGHLLLNNEKMSKSTGNF 726
Query: 659 LNFIDAIEENGADVVRLYIMSLAE--HDSDFDWRRKEVGKLR--RQLERFYELISQFAEY 714
+ +AIE+ AD +RL + + D++F + + LR +E E+I Q
Sbjct: 727 MTLEEAIEKFSADGMRLSLADAGDGLEDANFVYAMADAAILRLFTMIEWIKEMIEQRDAG 786
Query: 715 EAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGR 774
+++ + K D+ + +N I T + E + A++ F+ Y G
Sbjct: 787 LLRKDAK-KFADRVFANEMNSLIAATEQNYEATNFKDALKTGFFEYQAIRDTYRELCAGI 845
Query: 775 DDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP--EPVDEWWNEEV 832
D+ ++ + + + +++P PHI E +W+ LG +G + A WP +PVD E++
Sbjct: 846 DEPMSESLVFRFIETQMLILSPICPHIAEYIWQLLGKDGLIVNAPWPTVDPVD----EKL 901
Query: 833 EVEEDFI-KSLIE--------------DIKEIIEVAKIESPKRAYIYTA---PEWKWKVY 874
+ FI +SL E +KEI EV P A IY A P W+ +
Sbjct: 902 AIGARFITESLAEFRARLKTYMTPKKKALKEIPEV-----PTEAVIYVAKEYPPWQKTIL 956
Query: 875 EVVAEKREFKS-------AMAELM-KDEEIRKHGKEVAKLVQAIIKERAFDVK------- 919
+++ ++ + + A+++L+ K+E ++K K+ VQ +IKER F+ K
Sbjct: 957 DILEKQAKANNGALPDNKAISQLIGKEESLKKFAKKAMPFVQ-MIKER-FEQKGVSALAS 1014
Query: 920 --RIDEEKVLRESKDFLEKELGLEVIINPEEDKGG 952
+D+ +L E+ DF+ L L+ + D+ G
Sbjct: 1015 SSPVDQTSILNENIDFIMNALDLDRVTIRHTDEEG 1049
>gb|AAB60719.1| (AC000132) Strong similarity to S. pombe leucyl-tRNA synthetase
(gb|Z73100). [Arabidopsis thaliana]
Length = 1084
Score = 469 bits (1193), Expect = e-131
Identities = 327/1049 (31%), Positives = 516/1049 (49%), Gaps = 133/1049 (12%)
Query: 9 IEEKWQKRWLEAKVFEP-NIKDKPKE-KKFYITVAFPYLSGHLHVGHARTYTIPDVIARF 66
IE +K W + VF + ++ PK +KF+ T FPY++G+LH+GHA + + D + +
Sbjct: 17 IEATVRKWWEDEDVFRAESCENLPKPGEKFFSTFPFPYMNGYLHIGHAFSLSKVDFASAY 76
Query: 67 KRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPH----TIWIYRDVYKVPE--------- 113
R++G NVL P G+H TG PI A++++ ++ D KVPE
Sbjct: 77 HRLRGANVLLPFGFHCTGMPIKASADKLRREIEQFGNPPVFTAEDTTKVPEVQEESSDTI 136
Query: 114 --------------------------EILWTF----------EDPVNIVKYFMKAAKETF 137
EI+ +F +P + YF A E
Sbjct: 137 ALPIPGQFKGKKSKVAAKAGGQVYQWEIMRSFGLTDSEIANFREPSEWLYYFPPLAVEDL 196
Query: 138 IRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHD 197
G DW R F TT + P F F+ WQ KLK G IVK + P+ G P DHD
Sbjct: 197 RAYGLGCDWRRSFVTTDVNPFFDAFVRWQMRKLKSMGKIVKDRRYTIFSPLDGQPCADHD 256
Query: 198 LMEGEDVPILEYVIIKFE------LKEGD---ETIYLPAATLRPETVYGVTNMWINPNAT 248
GE V EY +IK E LK G + ++L AATLRPET+YG TN W+ P+
Sbjct: 257 RATGEGVQPQEYTLIKMEVVKPFPLKLGPLEGKRVFLAAATLRPETMYGQTNAWVLPDGK 316
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQD-----REIEVIEEFKGEKLIGKYVRNPVTGD 303
Y ++ + E +I+++ AA L++Q+ +E + E G LIG +R+P++ +
Sbjct: 317 YGAYEIS---ETEVFILTERAALNLAYQNFSKNPQEPSCLVELTGYDLIGLPLRSPLSVN 373
Query: 304 EVII-LPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPR-IVEEITY 361
E+I LP + + TG+V SVP+ AP D++AL+DL ++ + KY + + EI
Sbjct: 374 EIIYALPMLTILTNKGTGIVTSVPSDAPDDYMALQDLIKKPALQDKYGVKTEWLPTEI-- 431
Query: 362 ISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQ 421
I +I + +G+ A + L IKSQ D+EKL +A + Y + +G + + G+ VQ
Sbjct: 432 IPIINIPEFGDKAAEKVCLDLKIKSQNDKEKLAEAKRLTYLKGFTEGTMLIGEFFGRKVQ 491
Query: 422 EVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKA 481
E+K +I +++E G A I+Y EK V+SR G+ V+ + DQW+I YG SEW++ A +
Sbjct: 492 EIKPIIKTKLIETGEA-IIYSEPEKPVMSRSGDECVVALT-DQWYITYGESEWRKIAEEC 549
Query: 482 LARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTI 541
L++M +Y + R FE + WL++ AC+R GLGT +PWD ++++ESLSDS++YMAYYT+
Sbjct: 550 LSKMNLYSDETRHGFEHTLSWLNQWACSRSFGLGTRIPWDEQFLVESLSDSSLYMAYYTV 609
Query: 542 SR--HINRLREEGR--LDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEE 597
+ H + + + + P+++ E ++Y+F + K + IP+ ++ EMK+E
Sbjct: 610 AHIFHDGDMYKGSKSLIRPQQMNDEVWEYLFCDG-------PYPKSSDIPSAVLSEMKQE 662
Query: 598 FEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSKGN 657
F+YWYPLD R SGKDLI NHLTFFI+NH A+ +WP+GI NG L +KMSKS GN
Sbjct: 663 FDYWYPLDLRVSGKDLIQNHLTFFIYNHTALMANRNWPRGIRCNGHIMLNSEKMSKSTGN 722
Query: 658 VLNFIDAIEENGADVVRLYIMSLAEHDSD----FDWRRKEVGKLRRQLERFYELISQFAE 713
+IEE A R + + D F+ + +L ++L E++ E
Sbjct: 723 FRTLRQSIEEFSATGTRFCLADAGDGVDDANFAFETANAAILRLTKELTWMEEVLD--VE 780
Query: 714 YEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEG 773
+ DK + +N A+ T +A ++ R A++ FY + Y R
Sbjct: 781 SSLRTGPPSTYADKVFENDMNIALRLTERAYKDCLFREALKNGFYDLQAARDEY--RLSC 838
Query: 774 RDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEK-LGGEGFVSLAKWP---EPVDEWWN 829
+L K D+ RL+ P PH + +W K L EG V A WP EP D
Sbjct: 839 GTGGMHHDLLLKFMDVQTRLIVPICPHFADYVWRKVLNKEGCVLTAGWPPSNEP-DLVLK 897
Query: 830 EEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWK-------------WKVYEV 876
+ +D I + + +++ + +K + K A + PE K W+ + +
Sbjct: 898 SANKYLQDSIVLMRKLLQKQLSGSKKGAKKGAQVTAVPEGKLKGLVYVNEQFDGWRAHCL 957
Query: 877 VAEKREFKSAMAELMKDEEI-----------RKHGKEVAKLVQAIIKERAFDVKRI---- 921
+ F D E+ K+ K + K+ +K + + I
Sbjct: 958 RILQSRFDQQTCSFPPDTEMLAELSATLLQEGKNLKAIQKVCMPFLKFKKDEAISIGTQA 1017
Query: 922 -------DEEKVLRESKDFLEKELGLEVI 943
E +VL+ +KD + ++LGLE +
Sbjct: 1018 LNLRLPFGEIEVLQSNKDLIRRQLGLEEV 1046
>gb|AAF51096.1| (AE003579) CG3229 gene product [Drosophila melanogaster]
Length = 1376
Score = 462 bits (1176), Expect = e-129
Identities = 315/1026 (30%), Positives = 505/1026 (48%), Gaps = 129/1026 (12%)
Query: 45 LSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERI---------- 94
++G LH+GH + + + R+ R++G VL+P G+H TG PI A+++
Sbjct: 1 MNGRLHLGHTFSLSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFP 60
Query: 95 -------------------------KNRDPHTI---------WIYRDVYKVPEEILWTFE 120
K + + W + +E + F
Sbjct: 61 PQFPETEEVVPVAAEAASEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFA 120
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
+ + + YF A + R G VDW R F TT P F F+ WQF LKE+G I+ G
Sbjct: 121 NAEHWLNYFPPLAVQDLKRIGVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGK 180
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDET-------IYLPAATLRPE 233
+ P G P DHD GE V EY +IK ++ E + I++ AATLRPE
Sbjct: 181 RYTIYSPKDGQPCMDHDRSSGEGVGPQEYTLIKMKVLEVPKALSSIKQPIFMVAATLRPE 240
Query: 234 TVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQ-----DREIEVIEEFKG 288
T+YG TN W++P+ Y+ + + E W+ ++ AA +++Q + EI+V+ E G
Sbjct: 241 TMYGQTNCWLHPDIKYIAWQANKNN--EVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTG 298
Query: 289 EKLIGKYVRNPVTGDEVII-LPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILV 347
+ L+G + P+T +V+ LP + D TGVV SVP+ +P D+ AL DL+++
Sbjct: 299 QDLLGVPLSAPLTKHKVVYSLPMLSIKEDKGTGVVTSVPSDSPDDYAALVDLQKKEAFRQ 358
Query: 348 KYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHK 407
KY + +V I +I++ G+ AV + L I+SQ D++KL +A + Y ++
Sbjct: 359 KYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQSQNDKDKLAEAKEMCYLKSFYD 418
Query: 408 GIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFI 467
G+ V + G+ +Q+VK+ + K +++ A++ YE EK ++SR + V+ + + QW++
Sbjct: 419 GVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYE-PEKTIMSRSADECVVALCN-QWYL 476
Query: 468 DYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIE 527
+YG EW+ +A K L M+ + E R FEA ++WL + AC+R GLGT LPWD +W+IE
Sbjct: 477 NYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGTKLPWDDKWLIE 536
Query: 528 SLSDSTIYMAYYTISRHINRLREEGR------LDPEKLTPEFFDYIFLEEFSEEREKELE 581
SLSDSTIYMA+YT+ + G + P +T E +DYIF +E L
Sbjct: 537 SLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFF------KETPLP 590
Query: 582 KKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIF--REEHWPKGIA 639
KKT I E + ++ EFEYWYP+D R SGKDLI NHLTF ++NH AI+ E WPKG+
Sbjct: 591 KKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMR 650
Query: 640 VNGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAE--HDSDFDWRRKEVGKL 697
VNG L KMSKS GN L +A+++ AD +RL + + D++F + G L
Sbjct: 651 VNGHLLLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGIL 710
Query: 698 RRQLERFYELISQFAEYEA--KENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQW 755
R L F E + + E + ++ + D+ L LN + T + + + A++
Sbjct: 711 R--LYTFIEWVKEMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRS 768
Query: 756 AFYSIM---NDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGE 812
FY + + R +D F+ R+ L++P PH+ E +W LG +
Sbjct: 769 GFYELQLARDKYRELCGANGMHEDLVLEFIRRQ-----ALLVSPICPHMAEHVWGLLGNK 823
Query: 813 GFVSLAKWPE-----PVDEWWNEE-VEVEEDF---IKSLIE-------DIKEIIEVAKIE 856
+ A+WPE VD +E +E F +K+L++ D ++ AK
Sbjct: 824 ESIVHARWPEVGAINEVDILCSEYLMEAAHSFRLNLKNLLQIKGKAGKDKSVNVQAAK-- 881
Query: 857 SPKRAYIYTA---PEWKWKVYEVVAEKREFKSAM-------AELMKDEEIRKHGKEVAKL 906
P R ++ A P W+ V + + E A+ A L + E++K K V
Sbjct: 882 -PNRGLVWVAKTYPPWQCCVLDTMKELFNKSQALPDNKVIAATLQQKAELKKFMKRVMPF 940
Query: 907 VQAIIKERAFDVKRI---------DEEKVLRESKDFLEKELGLEVI-INPEEDKGGKKRQ 956
Q +I+E+ K + DE +VL + ++L+ L L+V+ I +D ++
Sbjct: 941 AQ-MIREKVESGKGVAALAVTLEFDERQVLISNLEYLKNTLDLDVLEIKYTDDPSAPEKT 999
Query: 957 AIPLKP 962
++P
Sbjct: 1000 REEVRP 1005
>sp|Q10490|SYLC_SCHPO PUTATIVE LEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (LEUCINE--TRNA LIGASE)
(LEURS) >gi|7492135|pir||T38407 leucyl-trna synthetase,
cytoplasmic - fission yeast (Schizosaccharomyces pombe)
>gi|1314182|emb|CAA97370.1| (Z73100) leucyl-trna
synthetase, cytoplasmic [Schizosaccharomyces pombe]
Length = 1111
Score = 451 bits (1147), Expect = e-125
Identities = 331/1064 (31%), Positives = 515/1064 (48%), Gaps = 147/1064 (13%)
Query: 9 IEEKWQKRWLEAKVFEPN--IKDKP------KEKKFYITVAFPYLSGHLHVGHARTYTIP 60
+E+K+Q++W E K FE + ++D P K KF+ + +PY++G LH+GHA T +
Sbjct: 32 LEKKYQQKWQEEKAFEVDAPLEDVPIDELRKKYPKFFGNMPYPYMNGALHLGHAFTLSKV 91
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNR--------------------DPH 100
+ F+R+ G VLFPMG+H TG PI A+R+ +
Sbjct: 92 EFTTAFERLNGKRVLFPMGFHCTGMPICASADRLSREIEMFGPSFDVPEEKEEEVEVEVK 151
Query: 101 TIWIYRDVYK--------------------------VPEEILWTFEDPVNIVKYFMKAAK 134
T DV K VP + F D + YF +
Sbjct: 152 TPNAREDVTKHSGKKSKAAAKTAAVKYQFQIMESLGVPRTEIHKFADAKYWLSYFPPLCQ 211
Query: 135 ETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLG 194
G +DW R F TT + P + F+ WQ L + G I G + G P
Sbjct: 212 RDCTEFGLGIDWRRSFITTDVNPYYDSFVRWQVNHLHDSGKIKFGERYTVYSIKDGQPCM 271
Query: 195 DHDLMEGEDVPILEYVIIKFELKEGDET--------------IYLPAATLRPETVYGVTN 240
DHD GE V EY IK E+ E E + + AATLRPET+YG TN
Sbjct: 272 DHDRKSGEGVGPQEYTGIKMEVLEFPEAARKALQSIDLSNKKVCMIAATLRPETMYGQTN 331
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQ--DREIEVIEEF---KGEKLIGKY 295
++ PN TY + E +I ++ AA +++Q +E V+ E KG+ LIG
Sbjct: 332 CYVGPNITY--GIYESNVPNELFICTRRAANNMAYQKLSKERGVVSELGTIKGQDLIGAL 389
Query: 296 VRNPVT-GDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPR 354
V P++ +V +LP E V TGVV SVP+ +P D L +L++++E Y ++P
Sbjct: 390 VNAPLSVHKQVYVLPMETVLATKGTGVVTSVPSDSPDDFATLTELRKKAEF---YHLNPE 446
Query: 355 IVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPP 414
++ + +I+ YG+ A +KL I+S KD ++L QA + YK +++G +
Sbjct: 447 WMK-YEAVPIIRTPSYGDMCAEFLCKKLKIQSPKDVKQLAQAKELAYKECFYQGTMIIGK 505
Query: 415 YDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEW 474
Y G+ V+ K + KE++++G+A +Y E VISR G+ ++ + DQWF+DYG + W
Sbjct: 506 YSGEKVETAKPKVRKELIDQGLA-FVYNEPEGQVISRSGDDCIVALC-DQWFLDYGEASW 563
Query: 475 KEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTI 534
K KAL R+ + R F +DWL + ACAR GLGT LPWDP++++ESL+DSTI
Sbjct: 564 KAVTEKALDRLNTFSPEVRNGFLKTLDWLSQWACARSYGLGTRLPWDPQFLVESLTDSTI 623
Query: 535 YMAYYTISRHIN-----RLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAE 589
YMAYYTI ++ ++ + PE++TPE +D++F R+ K T I E
Sbjct: 624 YMAYYTICHLLHSDVYGKVPGALNIKPEQMTPEVWDHVF-------RQAPKPKNTSISDE 676
Query: 590 IIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQ 649
+ + EF+Y+YP D R SGKDL+PNHLTF ++ H AIF E++WPKGI NG + G+
Sbjct: 677 ALARLCREFQYFYPFDIRASGKDLVPNHLTFCLYTHTAIFDEKYWPKGIRANGHLLMNGE 736
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKS GN + +A ++ GAD RL +LA+ D E + R Y
Sbjct: 737 KMSKSTGNFMTLHEATKKFGADATRL---ALADAGDTVDDANFEEALANSAILRLY--TQ 791
Query: 710 QFAEYEAKENVE-LKT-----IDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
+ E EN++ L+T DK + +N+ IE + +A + A++ FY + N
Sbjct: 792 EAWCKEMMENLDNLRTGPYNFHDKVFENEINQLIESSREAFSATLFKAALKSCFYDLQNA 851
Query: 764 LRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELW-EKLGGEGFVSLAKWPE 822
WY T D + R ++ + + V L+A F PH E +W L + ++
Sbjct: 852 RDWYREVT--ADRKMHRDLVCRWIETQVLLLATFAPHWSEHIWLTTLKKPQSIHVSGRFP 909
Query: 823 PVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIE-------------SPKRAYIYTA--- 866
V N + +I++L I+E E A+++ PKR ++ A
Sbjct: 910 QVSSPVNTALSNSLLYIRTLSRVIRE-AEAAQLKRQKKGKGMLFDPSKPKRLTVFVAEKF 968
Query: 867 PEWK-------WKVYEVVAEKREFKSAMAELMKDEEIRKHGKEVAKLVQAIIKERAFDVK 919
PEW+ K Y K + K+ ++ + K +E+++ + + Q++I R V
Sbjct: 969 PEWQAQYVALLQKYYNESENKFDDKAIISSVDK-KEMKRAMPFIQQFKQSVI-NRGEHVS 1026
Query: 920 R---------IDEEKVLRESKDFLEKELGLE----VIINPEEDK 950
+E +VLRE K +L + +G++ V++ DK
Sbjct: 1027 ANSIFSRELGFNELEVLREVKPYLVRNVGIQELRIVLLQKPADK 1070
>gi|6325097 cytosolic leucyl tRNA synthetase; Cdc60p [Saccharomyces cerevisiae]
>gi|135141|sp|P26637|SYLC_YEAST LEUCYL-TRNA SYNTHETASE,
CYTOPLASMIC (LEUCINE--TRNA LIGASE) (LEURS)
>gi|322939|pir||JC1421 leucine--tRNA ligase (EC 6.1.1.4),
cytosolic - yeast (Saccharomyces cerevisiae)
>gi|3508|emb|CAA44671.1| (X62878) Leucyl-tRNA synthetase
(cytoplasmic) [Saccharomyces cerevisiae]
>gi|1370340|emb|CAA97865.1| (Z73516) ORF YPL160w
[Saccharomyces cerevisiae] >gi|1403549|emb|CAA65561.1|
(X96770) P2564 protein [Saccharomyces cerevisiae]
Length = 1090
Score = 420 bits (1067), Expect = e-116
Identities = 320/1059 (30%), Positives = 501/1059 (47%), Gaps = 132/1059 (12%)
Query: 8 AIEEKWQKRWLEAKVFE---PNIKDKP----------KEKKFYITVAFPYLSGHLHVGHA 54
AIE+K+QK W E FE P+I+D+P KF ++A+PY++G +H GH
Sbjct: 18 AIEKKYQKIWAEEHQFEIDAPSIEDEPITMDSEELHRTYPKFMSSMAYPYMNGVMHAGHC 77
Query: 55 RTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNR----------------- 97
T + + F+RM G LFP+G+H TG PI+ A+++K
Sbjct: 78 FTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPAEEEE 137
Query: 98 ---DPHTIWIYRDVYK--------------------------VPEEILWTFEDPVNIVKY 128
+ + DV K +P E + F D + Y
Sbjct: 138 IKEETPAEKDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTY 197
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
F + G +DW R F TT P + FI WQ KLK G I G +
Sbjct: 198 FPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEK 257
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIKFELKE----------------GDETIYLPAATLRP 232
G DHD GE V EY+ +K E E + Y AATLRP
Sbjct: 258 DGQACMDHDRQSGEGVTPQEYIGVKIEALEFADDAAKIIDSSSDLDKSKKFYFVAATLRP 317
Query: 233 ETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYK-LSFQDRE-----IEVIEEF 286
ET+YG T +++P Y + G +++ I+ E A+K +S+Q + I
Sbjct: 318 ETMYGQTCCFVSPTIEY---GIFDAG--DSYFITTERAFKNMSYQKLTPKRGFYKPIVTV 372
Query: 287 KGEKLIGKYVRNPVTG-DEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEI 345
G+ IG + P + E+ ILP E V TGVV VP+++P D++ +DL + E
Sbjct: 373 PGKAFIGTKIHAPQSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEY 432
Query: 346 LVKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEY 405
Y I P ++ + ++ E YG+ A V++ I+S KD+ L +A K YK +Y
Sbjct: 433 ---YGIKPEWIDH-EIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDY 488
Query: 406 HKGIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQW 465
+ G PY G+ V++ K + +M+ G A +Y E V+SR G+ ++ + DQW
Sbjct: 489 YTGTMIYGPYKGEKVEQAKNKVKADMIAAGEA-FVYNEPESQVMSRSGDDCIVSL-EDQW 546
Query: 466 FIDYGNSEWKEKARKALARMKIY-PETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEW 524
++DYG WK++A + L M+++ PE + A FE ++DWL A R GLGT LPWD ++
Sbjct: 547 YVDYGEESWKKQAIECLEGMQLFAPEVKNA-FEGVLDWLKNWAVCRTYGLGTRLPWDEKY 605
Query: 525 VIESLSDSTIYMAYYTISRHINRLREEGRLDP-----EKLTPEFFDYIFLEEFSEEREKE 579
++ESLSDSTIY ++YTI+ + + + P +++T E FDYIF + ++
Sbjct: 606 LVESLSDSTIYQSFYTIAHLLFKDYYGNEIGPLGISADQMTDEVFDYIF-------QHQD 658
Query: 580 LEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIA 639
K T IP + +++ EFEY+YPLD SGKDLIPNHLTFFI+ HVA+F ++ WPKGI
Sbjct: 659 DVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIR 718
Query: 640 VNGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAE--HDSDFDWRRKEVGKL 697
NG L KMSKS GN + +E+ GAD R+ + D++FD L
Sbjct: 719 ANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAIL 778
Query: 698 RR-QLERFYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWA 756
R L+ + E I++ + E + D H +N IE T + + A+++
Sbjct: 779 RLFNLKEWAEEITKESNLRTGEITDF--FDIAFEHEMNALIEKTYEQYALTNYKNALKYG 836
Query: 757 FYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELW-EKLGGEGFV 815
+ R Y R G + ++ + + L+AP PH E ++ E LG + V
Sbjct: 837 LFD-FQAARDYYREASG---VMHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSV 892
Query: 816 SLAKWP---EPVDEWWNEEVEVEEDFIKSLIEDIKE-IIEVAKIESPKRAYIYTAPEWKW 871
AK+P +PVD + V D++++L I+E + K + K A I + K
Sbjct: 893 QNAKFPRASKPVD----KGVLAALDYLRNLQRSIREGEGQALKKKKGKSAEIDASKPVKL 948
Query: 872 KVYEVVAEK-REFKSAMAELMK---DEEIRKHGKEVAKLVQAIIKERAFDVKRIDEEKVL 927
+ +++E E++S E+++ E+ K+V + ++ +RA + ++++
Sbjct: 949 TL--LISESFPEWQSQCVEIVRKLFSEQTLDDNKKVREHIEPKEMKRAMPFISLLKQRLA 1006
Query: 928 RES-KDFLEKELGLEVIINPEEDKGGKKRQAIPLKPAVF 965
E +D E+EL I + K+ A LK A F
Sbjct: 1007 NEKPEDVFERELQFSEIDTVKAAARNVKKAAQALKIAEF 1045
>gb|AAG01037.1|AF293346_1 (AF293346) cytosolic leucyl-tRNA synthetase [Candida albicans]
Length = 1097
Score = 416 bits (1057), Expect = e-115
Identities = 305/984 (30%), Positives = 460/984 (45%), Gaps = 140/984 (14%)
Query: 9 IEEKWQKRWLEAKVFE---PNIKDKPKEK---------KFYITVAFPYLSGHLHVGHART 56
IE+K+QK W E KVFE P ++ P E KF+ T+A+PY++G LH GHA T
Sbjct: 19 IEKKYQKVWAEEKVFEVDAPTFEECPIEDVEQVQEAHPKFFATMAYPYMNGVLHAGHAFT 78
Query: 57 YTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERI---------------------- 94
+ + F+RM G LFP+G+H TG PI A++I
Sbjct: 79 LSKVEFATGFQRMNGKRALFPLGFHCTGMPIKAAADKIKREVELFGSDFSKAPIDDEDAE 138
Query: 95 KNRDPHTIWIYR-DVYK--------------------------VPEEILWTFEDPVNIVK 127
+++ P R DV K +P E + F + ++
Sbjct: 139 ESQQPAKTETKREDVTKFSSKKSKAAAKQGRAKFQYEIMMQLGIPREEVAKFANTDYWLE 198
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+F ++ G VDW R TT P + F+ WQ +L++ G I G +
Sbjct: 199 FFPPLCQKDVTAFGARVDWRRSMITTDANPYYDAFVRWQINRLRDVGKIKFGERYTIYSE 258
Query: 188 VVGTPLGDHDLMEGEDVPILEYVIIKFELKE----------------GDETIYLPAATLR 231
G DHD GE V EYV IK L + + +YL AATLR
Sbjct: 259 KDGQACLDHDRQSGEGVGPQEYVGIKIRLTDVAPQAQELFKKENLDVKENKVYLVAATLR 318
Query: 232 PETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDRE-----IEVIEEF 286
PET+YG T +++P Y V G + +I ++ A +SFQ+ + +
Sbjct: 319 PETMYGQTCCFVSPKIDY---GVFDAGNGDYFITTERAFKNMSFQNLTPKRGYYKPLFTI 375
Query: 287 KGEKLIGKYVRNPVTGDEVI-ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEI 345
G+ LIG + P ++ + +LP E V TGVV VP+ +P D V DL + E
Sbjct: 376 NGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSPDDFVTTRDLANKPEY 435
Query: 346 LVKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEY 405
Y I+ V+ + ++ E YG+ A V L I+S KD +L A + YK +
Sbjct: 436 ---YGIEKDWVQT-DIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLANAKELAYKEGF 491
Query: 406 HKGIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQW 465
+ G + Y G V++ K + ++++++G+A +Y E VISR G+ + + DQW
Sbjct: 492 YNGTMLIGKYKGDKVEDAKPKVKQDLIDEGLA-FVYNEPESQVISRSGDDCCVSL-EDQW 549
Query: 466 FIDYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWV 525
+IDYG W +A + L M+ Y + R FE ++ W+ A RK GLGT LPWDP+++
Sbjct: 550 YIDYGEEVWLGEALECLKNMETYSKETRHGFEGVLAWMKNWAVTRKFGLGTKLPWDPQYL 609
Query: 526 IESLSDSTIYMAYYTISRHINRL---REEGRLD--PEKLTPEFFDYIFLEEFSEEREKEL 580
+ESLSDST+YMAYYTI R ++ ++ G+ D PE++T E FDYIF R ++
Sbjct: 610 VESLSDSTVYMAYYTIDRFLHSDYYGKKAGKFDIKPEQMTDEVFDYIFT------RRDDV 663
Query: 581 EKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAV 640
E T IP E + EM+ EFEY++PLD R SGKDLIPNHLTFFI+ HVA+F + WP+G+
Sbjct: 664 E--TDIPKEQLKEMRREFEYFHPLDVRVSGKDLIPNHLTFFIYTHVALFPKRFWPRGVRA 721
Query: 641 NGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAE--HDSDFDWRRKEVGKLR 698
NG L KMSKS GN + IE+ GAD R+ + + D++FD LR
Sbjct: 722 NGHLLLNNAKMSKSTGNFMTLEQIIEKFGADASRIAMADAGDTVEDANFDEANANAAILR 781
Query: 699 RQLERFYELISQFAEYEAKENVELKT------IDKWLLHRLNKAIEGTTKALEEFRTRTA 752
+ + E E K +L+ D + +N IE T + + A
Sbjct: 782 ------LTTLKDWCEEEVKNQDKLRIGDYDSFFDAAFENEMNDLIEKTYQQYTLSNYKQA 835
Query: 753 VQWAFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELW-EKLGG 811
++ + Y + ++ K + ++AP PH E L+ E LG
Sbjct: 836 LKSGLFDFQIARDIYRESVNTTGIGMHKDLVLKYIEYQALMLAPIAPHFAEYLYREVLGK 895
Query: 812 EGFVSLAKWP---EPVDEWWNEEVEVEEDFIKSLIEDIKEI-------------IEVAKI 855
G V +K+P +PV ++ + ++++SL I+E ++ +K
Sbjct: 896 NGSVQTSKFPRASKPV----SKAILDASEYVRSLTRSIREAEGQALKKKKGKSDVDGSKP 951
Query: 856 ESPKRAYIYTAPEWKWKVYEVVAE 879
S T PEW+ E+V E
Sbjct: 952 ISLTVLVSNTFPEWQDNYIELVRE 975
>dbj|BAB14674.1| (AK023777) unnamed protein product [Homo sapiens]
Length = 928
Score = 403 bits (1024), Expect = e-111
Identities = 275/839 (32%), Positives = 434/839 (50%), Gaps = 86/839 (10%)
Query: 195 DHDLMEGEDVPILEYVIIKFELKEG---------DETIYLPAATLRPETVYGVTNMWINP 245
DHD GE V EY ++K ++ E + I+L AATLRPET++G TN W+ P
Sbjct: 2 DHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRP 61
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLSFQ-----DREIEVIEEFKGEKLIGKYVRNPV 300
+ Y+ + G + +I +++AA +S+Q + + V++E GE+++G + P+
Sbjct: 62 DMKYIGFETVNG---DIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPL 118
Query: 301 TGDEVI-ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEI 359
T +VI +LP + D TGVV SVP+ +P D AL DLK++ + KY I +V
Sbjct: 119 TSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPF 178
Query: 360 TYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKP 419
+ +I++ G+G AV +L I+SQ DREKL +A + IY +++GI V + G+
Sbjct: 179 EPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQK 238
Query: 420 VQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKAR 479
VQ+VK+ I K+M++ G A ++Y EK V+SR + V+ + DQW++DYG WK++
Sbjct: 239 VQDVKKTIQKKMIDAGDA-LIYMEPEKQVMSRSSDECVVALC-DQWYLDYGEENWKKQTS 296
Query: 480 KALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYY 539
+ L ++ + E R FEA + WL + AC+R GLGT LPWD +W+IESLSDSTIYMA+Y
Sbjct: 297 QCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTQLPWDEQWLIESLSDSTIYMAFY 356
Query: 540 TISRHINRLREEGRLD------PEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHE 593
T++ + G+ + +++T E +DY+F +E KT I E + +
Sbjct: 357 TVAHLLQGGNLHGQAESPLGIRSQQMTKEVWDYVFFKEAP-------FPKTQIAKEKLDQ 409
Query: 594 MKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFRE--EHWPKGIAVNGFGTLEGQKM 651
+K+EFE+WYP+D R SGKDL+PNHL+++++NHVA++ E + WP + NG L +KM
Sbjct: 410 LKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKM 469
Query: 652 SKSKGNVLNFIDAIEENGADVVRLYIMSLAE--HDSDFDWRRKEVGKLRRQLERFYELIS 709
SKS GN L AI++ AD +RL + + D++F + G LR L + E +
Sbjct: 470 SKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILR--LYTWVEWVK 527
Query: 710 QF-AEYEAKENVELKTI-DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWY 767
+ A +++ + T D+ LN I T + E+ A++ F+ Y
Sbjct: 528 EMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFIEALKTGFFEFQAAKDKY 587
Query: 768 MR-RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP--EPV 824
EG E ++ + ++ L+APF PH+CE +W LG + A WP PV
Sbjct: 588 RELAVEGMHRE----LVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPV 643
Query: 825 DEWWNEEVEVEEDFIKSLIEDIKEIIEVAK--------IESPKRAYIYTA---PEWKWKV 873
+E + + L +K + AK ++ P IY A P W+
Sbjct: 644 NEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTT 703
Query: 874 YEVVAEKREF--------KSAMAELMKDEEIRKHGKEVAKLVQAIIKE-------RAFDV 918
V+ + E K +EL E++K+ K+V V A+IKE R D+
Sbjct: 704 LSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFV-AMIKENLEKMGPRILDL 762
Query: 919 K-RIDEEKVLRESKDFLEKELGLEVI----INPEEDK------GGKKRQAIPLKPAVFI 966
+ DE+ VL E+ +L L LE I + EDK GK ++P V +
Sbjct: 763 QLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSV 821
>sp|P10857|SYLC_NEUCR LEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (LEUCINE--TRNA LIGASE) (LEURS)
>gi|68517|pir||SYNCLC leucine--tRNA ligase (EC 6.1.1.4),
cytosolic - Neurospora crassa >gi|168832|gb|AAA33593.1|
(M30473) leucyl-tRNA synthetase [Neurospora crassa]
Length = 1123
Score = 388 bits (985), Expect = e-106
Identities = 311/1078 (28%), Positives = 496/1078 (45%), Gaps = 154/1078 (14%)
Query: 9 IEEKWQKRWLEAKVFE---PNIKDKP-----------KEKKFYITVAFPYLSGHLHVGHA 54
IE+++Q++W + VFE P+ + P K KF+ T+A+PY++G LH GHA
Sbjct: 36 IEKRYQQKWEQEGVFEVDAPSTAEFPLDAITPDELRQKHPKFFGTIAYPYMNGRLHAGHA 95
Query: 55 RTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEE 114
+++ + F RMQG LFP G+H TG PI A+++ ++ + YK E
Sbjct: 96 FSFSKIEYHTGFARMQGKRALFPQGYHCTGLPIKASADKLV-KEIEMFGQEFERYKEDEV 154
Query: 115 ILW----------TFEDPVNI-------------VKYFMKAAKETFIRAGFSVDWSREFY 151
+ T ED KY + K I ++ Y
Sbjct: 155 VEGAAPAAAAAPKTKEDLTKFNAKKGKTVAKTGGAKYQFQILKSLGIPVSEIHKFADPQY 214
Query: 152 TTSLFPP--------FSKFIEW-------------------QFLKLKEKGYIVKGAHRVR 184
FPP F I+W Q +L E I G
Sbjct: 215 WLHYFPPECKKDLTNFGARIDWRRQFVTTDANPYYDAFVRWQMNRLLELNKIKFGKRYTI 274
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKE--------------GDETIYLPAATL 230
+ G P DHD EGE V EY +K ++ E +YL ATL
Sbjct: 275 YSIKDGQPCMDHDRSEGEGVLPQEYTALKLKVTEWAPKAAEALKGKLPEGANVYLCPATL 334
Query: 231 RPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQ-----DREIEVIEE 285
RPET+YG ++ P Y V + + E ++I++ AA +++Q + IE +
Sbjct: 335 RPETMYGQVCCFVGPALKY---GVFKAAENEYFVITERAAKNMAYQGIFEKEGVIEKAAD 391
Query: 286 FKGEKLIGKYVRNPVT-GDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESE 344
G LIG V P++ EV +LP + V TGVV SVP+ +P D + +L ++ E
Sbjct: 392 IVGSDLIGTLVNAPLSVHKEVYVLPMDTVLATKGTGVVTSVPSDSPDDCAMMTELAKKPE 451
Query: 345 ILVKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAE 404
Y I E+ +S+IK + A V+KL I S KD ++L +A + YK
Sbjct: 452 F---YGIQKEWAEK-EIVSVIKTP-TSDLLAPYLVKKLKINSPKDAKQLLEAKELAYKEG 506
Query: 405 YHKGIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQ 464
+++GI + G+ V+ K + +++++ G A Y E V+SR G+ + ++ DQ
Sbjct: 507 FYQGIMNYGDFKGEKVETAKPKVRQQLIDAGDA-FAYSEPENKVVSRSGDECSVALM-DQ 564
Query: 465 WFIDYGNSEWKE------KARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPL 518
W+IDYG W+ + + Y +T+ A F+ +I WL + ACAR GLG+ L
Sbjct: 565 WYIDYGEDSWRTVLYDYVENKDGKGINTYYADTQHA-FKGVIGWLKQWACARTYGLGSKL 623
Query: 519 PWDPEWVIESLSDSTIYMAYYTISRHIN-----RLREEGRLDPEKLTPEFFDYIFLEEFS 573
PWDP +++ESLSDST+YMAYYT++ ++ R + +G + +++ E +DYIF
Sbjct: 624 PWDPNFLVESLSDSTVYMAYYTVAHWLHRDLFGREKGKGNIGADQMIDEVWDYIFCR--- 680
Query: 574 EEREKELEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEH 633
E L K+GIP E + M+ EF+Y+YPLD R SGKDLIPNHLTF+++NH+A+F E+
Sbjct: 681 TELSDHLVTKSGIPKETLDSMRREFQYFYPLDIRVSGKDLIPNHLTFWLYNHIALFPREY 740
Query: 634 WPKGIAVNGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKE 693
WPK + NG L G+KMSKS GN + D +++ GAD R+ + + SD ++
Sbjct: 741 WPKSVRANGHLQLNGEKMSKSTGNFMTLDDVVKKYGADAARVALADAGDGISDSNFVEDV 800
Query: 694 VGKLRRQLERFY---ELISQFAEYEAKENVELKTIDKWLL-HRLNKAIEGTTKALEEFRT 749
+ RFY E I + + E+ EL + L + +N + K EE
Sbjct: 801 AD---NTILRFYTNKEWIEETLKDESLRTGELNSFQDALFDNEMNALVNEARKHYEETSY 857
Query: 750 RTAVQWAFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEK- 808
+ A++ A Y +N Y + ++ K + ++ P PH + +W++
Sbjct: 858 KLALKAAHYDFLNARDMYREACAAAGIPLHKDLVTKYIRLQALVITPIAPHWADYVWQEC 917
Query: 809 LGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIK--EIIEVAKI----------E 856
LG + A+WPE N + D++++ I E ++ K+ +
Sbjct: 918 LGEPKSIQFARWPEVPAA--NPALTAARDYVRTTSSAINSAEAAQLKKMAKGRQSDFDPK 975
Query: 857 SPKRAYIYTA---PEWKWKVYEVVAEKREFKSAMAELMKDE---EIRKHG--KEVAKLVQ 908
PK+ I+ P W+ K ++++E + + ++ E I K G K+ VQ
Sbjct: 976 KPKKLTIFATENFPTWQAKYIDLLSEVWDAATGTQKIDDKELNGRIAKMGEMKKAMPFVQ 1035
Query: 909 AIIKERAFDVK----------RIDEEKVLRESKDFLEKELGLE---VIINPEEDKGGK 953
A +K+R D + DE+ L L++ GLE V++ E K GK
Sbjct: 1036 A-LKKRLKDGEPAEQILSRKLSFDEKATLLAMIPGLKRTAGLESVQVVLVEEGSKTGK 1092
>sp|Q9V072|SYI_PYRAB ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437558|pir||H75139 isoleucyl-tRNA synthetase (iles)
PAB0616 - Pyrococcus abyssi (strain Orsay)
>gi|5458344|emb|CAB49833.1| (AJ248285) isoleucyl-tRNA
synthetase (ileS) [Pyrococcus abyssi]
Length = 1067
Score = 204 bits (514), Expect = 4e-51
Identities = 238/993 (23%), Positives = 418/993 (41%), Gaps = 165/993 (16%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKE-KKFYITVAFPYLSGHLHVGHARTYTIPD 61
E + + +EEK +K W E +++ +K+ K+ K+Y PY+SG +H+G A I D
Sbjct: 9 EYDPKKLEEKVEKFWSENEIYR-KVKELRKDGPKYYFLDGPPYVSGAIHLGTAWNKIIKD 67
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPI-----VGIAERIKNRDPHTIWIYRDVYKVPEEIL 116
+I RF+ MQGYNV G+ + G PI + + K I + + K E L
Sbjct: 68 MIIRFRTMQGYNVWRQPGYDMHGLPIEVKVEQALGLKTKKEIEEKIGVENFIKKCKEFAL 127
Query: 117 WTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLK---EK 173
+K E F G +DW + T +++IE + LK EK
Sbjct: 128 NN-----------LKIMTEQFKMLGIWMDWDNPYMTIK-----NEYIESAWFTLKRAWEK 171
Query: 174 GYIVKGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPE 233
G + K + W P T L +H++ + + +KF + EG E YL T P
Sbjct: 172 GLLEKDKRVLHWCPRCETALAEHEVRGEYKLRKDPSIYVKFPV-EGKENEYLLIWTTTPW 230
Query: 234 TVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYK-LSFQDREIEVIEEFKGEKLI 292
T+ + +P+ YVK KV+ G+EE WI++K K L + EV+EEFKG +L
Sbjct: 231 TLPANLAVSAHPDYDYVKVKVEFNGREEYWILAKALVDKVLGEIGVKGEVVEEFKGRELE 290
Query: 293 G-KYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDI 351
G +YV H+ +++ R+ E KY+
Sbjct: 291 GLRYV------------------------------------HILMDEYPRQKEFKEKYEW 314
Query: 352 DPRIVEEITYISLIKLEGYGEFPAVEE----VQKLGIKSQKDREKLEQATKTIYKAEYHK 407
R++ +F +EE V ++D E ++ +Y +
Sbjct: 315 AHRVI-------------LADFVTLEEGTGLVHTAPGHGEEDFEVGQKYGLPVYSPLDDQ 361
Query: 408 GIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFI 467
G + + G V+E I + + EKG E K +I DQWF+
Sbjct: 362 GKYTEGKWKGIYVKEADPKIIEHLREKGYLVKAGEIEHKYPHCWRCKTPLIFRATDQWFL 421
Query: 468 DYGNSEWKEKARKAL-ARMKIYPETRRAQFEAII----DWLDKKACARKVGLGTPLP-WD 521
S+ K+K K ++ YP+ + +F+ + DW+ +R+ G PLP W
Sbjct: 422 KI--SKVKDKIIKENDEKVTWYPDWVKIRFDNGVRDSGDWV----ISRQRYWGIPLPIWQ 475
Query: 522 PE----WVIESLSDSTIYMAYYTISRHINRLRE---------EGRLDPEKLTPEFFDYIF 568
E +V+ S + ++ L E E +L PE L + D
Sbjct: 476 SEDGEIYVVGSWRELVELAVAIEVNGERIELPESYEEKLKVIEEKLGPEDLHRPYVDAFI 535
Query: 569 LEEFSEEREK-----ELEKKTGIPAEI---IHEMKEEFEYWYPLDWRCSGKDLIPNHLTF 620
++ ++ + ++ +GI + KE FE +P D+ G+D + F
Sbjct: 536 IKVNGKDMRRVKDVVDVWFDSGIASWASLGYPRNKELFEKLWPADFIVEGEDQVTK--WF 593
Query: 621 FIFNHVAIFREEHWP-KGIAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIM 678
+ +I + P + +A++G+ E G KMSKS GN++ + +E G D R Y++
Sbjct: 594 YSQQAASIVAFDTVPYRRVAMHGYVLDEKGDKMSKSLGNIIRPEEVVERAGRDTFRFYML 653
Query: 679 SLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENVELKTI----------DKW 728
+ + K V ++RR L + + + Y + +N + + + DKW
Sbjct: 654 WATNPWENLKFSWKGVEQVRRMLNILWNVYVLASTYMSLDNFDPRKLNPDELPFREEDKW 713
Query: 729 LLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RWYMRR------TEGRDDE--AK 779
+L R+N I +E F A + + ++ DL RWY+R EG D + A
Sbjct: 714 ILSRVNSLISEVENGIESFYLTKATRALYNFVVEDLSRWYVRLIRKRLWVEGEDPDKLAA 773
Query: 780 RFVLRKLADIWVRLMAPFTPHICEELWEKL----GGEGFVSLAKWPEPVDEWWNEEVEVE 835
+ L K+ D+ +RL+APFTP+I EE+++ L V + WP+ ++ +EE+E E
Sbjct: 774 YYTLWKVFDVLLRLLAPFTPYIAEEIYQNLIRPFTNVESVHMLDWPKVDEKAIDEELERE 833
Query: 836 EDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEE 895
+FI+ ++E + AKI + ++ V ++ E +DE
Sbjct: 834 MEFIRRIVEAGSAARQRAKI------------KLRYPVRRIIIE-----------TEDET 870
Query: 896 IRKHGKEVAKLVQAIIKERAFDVKRIDEEKVLR 928
++K + + ++++ + + V R++ E ++
Sbjct: 871 VKKAVERLNRILRDQLNAKEVKVGRVERELTIK 903
>sp|O58792|SYI_PYRHO ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437549|pir||F71100 isoleucine--tRNA ligase (EC
6.1.1.5) - Pyrococcus horikoshii
>gi|3257481|dbj|BAA30164.1| (AP000004) 1066aa long
hypothetical isoleucyl-tRNA synthetase [Pyrococcus
horikoshii]
Length = 1066
Score = 203 bits (510), Expect = 1e-50
Identities = 228/902 (25%), Positives = 381/902 (41%), Gaps = 140/902 (15%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
+EEK ++ W E +++ + + K+Y PY+SG +H+G A I D+I RF+
Sbjct: 15 LEEKIEEFWKENNIYQKIKELRKNGPKYYFLDGPPYVSGAIHLGTAWNKIIKDMIIRFRT 74
Query: 69 MQGYNVLFPMGWHITGSPIVGIAE-----RIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
MQGYNV G+ + G PI E + K I + + K E L
Sbjct: 75 MQGYNVWRQPGFDMHGLPIEVKVEQALGLKTKKEIEEKIGVENFIKKCKEFALNN----- 129
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLK---EKGYIVKGA 180
+K E F G +DW + T +++IE + LK EKG + K
Sbjct: 130 ------LKIMTEQFKMLGIWMDWDDPYMTIK-----NEYIESAWFTLKKAWEKGLLEKDK 178
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
+ W P T L +H++ + + +KF + EG E YL T P T+
Sbjct: 179 RVLHWCPRCETALAEHEVRGEYKLRKDPSIYVKFPI-EGKENEYLLIWTTTPWTLPANLA 237
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQ-DREIEVIEEFKGEKLIG-KYVRN 298
+ +P YVK KV+ GKEE WI++K K+ + + EVIEEFKG +L G +Y+
Sbjct: 238 VSAHPEYDYVKVKVEFNGKEEYWILAKALVDKVLGEIGVKGEVIEEFKGRELEGLRYI-- 295
Query: 299 PVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEE 358
HV +++ R+ E KY+ RI+
Sbjct: 296 ----------------------------------HVLMDEYPRQKEFREKYEWAHRII-- 319
Query: 359 ITYISLIKLEGYGEFPAVEE----VQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPP 414
+F +EE V ++D E ++ IY +G +
Sbjct: 320 -----------LADFVTLEEGTGLVHTAPGHGEEDFEVGKKYGLPIYSPVDDQGRYVEGK 368
Query: 415 YDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEW 474
+ G V+E I + + EKG E K +I DQWF+ S+
Sbjct: 369 WKGIYVKEADPQIIEHLKEKGYLVKAGEIEHKYPHCWRCKTPLIFRATDQWFLKV--SKV 426
Query: 475 KEKARKAL-ARMKIYPETRRAQFEAII----DWLDKKACARKVGLGTPLP-WDPE----W 524
K++ K ++ YP+ + +F+ + DW+ +R+ G PLP W E +
Sbjct: 427 KDRIIKENDEKVTWYPDWVKIRFDNGVRDSGDWV----ISRQRYWGIPLPIWQSEDGEIY 482
Query: 525 VIESLSDSTIYMAYYTISRHINRLRE---------EGRLDPEKLTPEFFDYIFLEEFSEE 575
V+ S + ++ L E E +L PE L + D ++ +E
Sbjct: 483 VVGSWRELVELAVAIEVNGERIDLPESYEEKLKVIEEKLGPEDLHRPYVDAFIIKVNGKE 542
Query: 576 REK-----ELEKKTGIPAEI---IHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVA 627
+ ++ +GI + KE FE +P D+ G+D + F+ +
Sbjct: 543 MRRVKDVVDVWFDSGIASWASLGYPRNKELFEKLWPADFIVEGEDQVTKW--FYSQQAAS 600
Query: 628 IFREEHWP-KGIAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDS 685
+ + P + +A++G+ E G KMSKS GN++ + +E+ G D R Y++
Sbjct: 601 VIAFDTVPYRRVAMHGYVLDEKGDKMSKSLGNIIRPEEVVEKAGRDTFRFYMLWATNPWE 660
Query: 686 DFDWRRKEVGKLRRQLERFYELISQFAEYEAKENVELKTI----------DKWLLHRLNK 735
+ + K V ++RR L + + A Y + +N + + + DKW+L R+N
Sbjct: 661 NLKFSWKGVEQVRRMLNILWNVYVLSATYMSLDNFDPRNVKVEELAFREEDKWILSRVNS 720
Query: 736 AIEGTTKALEEFRTRTAVQWAFYSIMNDL-RWYMRR------TEGRDDE--AKRFVLRKL 786
I +E F A + + ++ DL RWY+R EG D + A + L K+
Sbjct: 721 LIREVENGIETFYLTKATRALYNFVVEDLSRWYVRLIRKRLWVEGDDPDKLAAYYTLWKV 780
Query: 787 ADIWVRLMAPFTPHICEELWEKLG----GEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSL 842
D+ +RLMAPFTP+I EE+++ L G V + WP+ + +E++E E +FI+ +
Sbjct: 781 FDVLLRLMAPFTPYITEEIYQNLMRPFIGIESVHMLDWPKVDESAVDEDLEKEMEFIRRI 840
Query: 843 IE 844
+E
Sbjct: 841 VE 842
>sp|Q58413|SYV_METJA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|2129352|pir||F64425 valine--tRNA ligase (EC 6.1.1.9)
- Methanococcus jannaschii >gi|1591666|gb|AAB99009.1|
(U67543) valyl-tRNA synthetase (valS) [Methanococcus
jannaschii]
Length = 878
Score = 185 bits (466), Expect = 2e-45
Identities = 253/992 (25%), Positives = 418/992 (41%), Gaps = 195/992 (19%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE++ QK+W E+K+++ ++ + + I PY +G LH+GHA +T D+IAR+KR
Sbjct: 11 IEKQIQKKWEESKIYK--FDEESNKPPYIIDTPPPYPTGRLHLGHALNWTYMDIIARYKR 68
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M+G+NVLFP GW G P E I + D +K E + + K
Sbjct: 69 MKGFNVLFPQGWDCHGLPTEVKVEEIHGITKSDV----DRHKFRELC-------IELTKE 117
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
++ + G S+DW +E+ T + P + K + F+++ + G I +G V W P
Sbjct: 118 NIEKMRRQIKSLGISIDWDKEYIT--MTPEYIKKSQTAFVRMYKDGLIYRGKFPVNWCPR 175
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNAT 248
T + ++ E L Y IKF +G+ +L AT RPE + + ++P
Sbjct: 176 CQTAIAFAEVEYKERESKLNY--IKFPAADGEG--HLLIATTRPELMAACVAILVHP--- 228
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIIL 308
E+ + + LIGK P+ G +V +L
Sbjct: 229 -----------------------------------EDERYKHLIGKEFIVPLFGHKVKLL 253
Query: 309 PAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLE 368
E V+ + TG VM D + + K E +K ID + E+T I+
Sbjct: 254 ADEDVEKEFGTGAVMVCTFGDKTDVLWVNRHKLE----IKKAIDEK--GELTEIA----- 302
Query: 369 GYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQEVKELIA 428
G++ G+K+++ REK+ + K K Y + K P +K+ +
Sbjct: 303 --GKYK--------GLKTEEAREKIIEDLK---KEGY---LVKQEP--------IKQNVG 338
Query: 429 KEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALARMKIY 488
K EI I+ +QWF++ K+
Sbjct: 339 VCWRCKTPIEI--------------------IVTEQWFVNV---------------RKLI 363
Query: 489 PETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVI--ESLSDSTIYMAYYTISRHIN 546
P+ R E I W+ + R + + WD WVI + + + I + Y ++
Sbjct: 364 PKVREVADE--IKWIPEHMKIRLLNWIEDMDWD--WVISRQRIFATPIPVWYCPKCGNVV 419
Query: 547 RLREEG-RLDPEKLTPEFFDYIFLEEFSEERE-KELEKKTGIPAEIIHEMKEE---FEYW 601
+EE +DP K T D ++ E + + + I +I + ++ FE
Sbjct: 420 VAKEEDLPIDPTK-TGYVCDKCGNKDLIPETDVLDTWMDSSITPMVITKWLDDDKFFEKH 478
Query: 602 YPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNG--FGTLEGQKMSKSKGNVL 659
YP+ R G D+I + I VA+ ++ W + I +NG FG +G KMSKS+GNV+
Sbjct: 479 YPVQLRPQGHDIIRTWAFYTIVKSVALTGKKPWDE-IVINGMVFGE-DGHKMSKSRGNVV 536
Query: 660 NFIDAIEENGADVVRLYIM-SLAEHDSDFDWRRKEVGK--LRRQLE--RFYEL-ISQFAE 713
+ I + GAD +RL+ S+ D F W+ + G LR+ RF ++ IS
Sbjct: 537 EPDEIIAKYGADALRLWASNSVVGDDVQFLWKEVDYGYRFLRKSWNACRFAKMHISDDII 596
Query: 714 YEAKENVELKT-IDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIM------NDLRW 766
E K+ +E+ ID W+L +L + IE K LE +R T V+ Y + N +
Sbjct: 597 DELKKPMEISNPIDLWILSKLQRLIERVDKDLENYRFNTIVE--IYKFVWHEFCDNYIEM 654
Query: 767 YMRRTEGRDDEAK---RFVLRKLADIWVRLMAPFTPHICEELWE--KLGGEGFVSLAKWP 821
R G D+EAK R+ L + D VRL+ PF PH + + E K+ F +P
Sbjct: 655 VKYRLYGDDEEAKKEARWTLYYVIDKVVRLLCPFAPHFSDYIAEIYKIDNLHF----SFP 710
Query: 822 EPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVA--KIESP-KRAYIYTAPE---------- 868
E + + NEE E + K+ + I+ + + +P K IYT E
Sbjct: 711 EVDNRFINEEAEKFGEIAKNTVISIRRFKANSGMALNAPLKYVEIYTEDEETYLALNKTA 770
Query: 869 ------WKWKVYEVVAEKREFKSAMAELMKDEEIRKHGKEVAKLVQAIIKERAFDVKRID 922
K + +++ K +S + E++ D+ K G E K +A++ +K D
Sbjct: 771 EDIKGTLKIEELKIIKGKPALESKIVEIIPDKS--KIGPEFKKNAKAVMDL----IKNAD 824
Query: 923 EEKVLRESKDFLEKELGLEVIINPEEDKGGKK 954
EE + + + LE E G +I E K K+
Sbjct: 825 EETLEKIINEGLETEYG---VIRKEHIKDVKR 853
>sp|Q9XDB4|SYI_FERPE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|4836216|gb|AAD30388.1|AF096862_2 (AF096862)
isoleucyl-tRNA synthase [Fervidobacterium pennivorans]
Length = 897
Score = 171 bits (429), Expect = 3e-41
Identities = 201/880 (22%), Positives = 359/880 (39%), Gaps = 126/880 (14%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
E + K W E ++++ ++ + + + PY +G +H+G A + D + R+K M
Sbjct: 9 EPEMLKFWEEKEIYKKTLETRANAPTYLLHDGPPYANGDIHLGTAMNKILKDFVTRYKTM 68
Query: 70 QGYNVLFPMGWHITGSPI-----VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
+GY V F GW G PI + E K + P ++ K+ +E + D
Sbjct: 69 RGYRVPFVPGWDTHGLPIEHRVTTSLGEEAKKKSP------AEIRKLCKEFALKYVD--- 119
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
+E F R G DW + T L P + I F L E G + +G V
Sbjct: 120 -------IQREEFKRLGVKGDWEHPYIT--LDPDYEYHILDVFKTLVENGNVYRGNKPVY 170
Query: 185 WDPVVGTPLGDHDL-MEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWI 243
W P T L + ++ + P + +KF++ + +T Y+ T P T+ + +
Sbjct: 171 WCPTCRTALAEAEIEYHDHESP---SIYVKFQMVDKPDT-YIVIWTTTPWTIPANVAIAL 226
Query: 244 NPNATYVKAKVKRGGKEETWIISKEAAYKLSFQ-DREIEVIEEFKGEKLIGKYVRNPVTG 302
+P+ TYVK KV EE WI+++ K + + EV+E+F G++L GK ++P+
Sbjct: 227 HPDYTYVKIKV----DEEYWIVAEGLLQKFAADVGIDFEVVEKFVGKELEGKLTKHPLYD 282
Query: 303 DEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYI 362
+++ A++V ++ TG V + P H D+ LK +L D + R +E
Sbjct: 283 RTSVVVLADYVTLEDGTGCVHTAPGHGEEDYQT--GLKYNLPVLSPVDDEGRFTKEAG-- 338
Query: 363 SLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQE 422
K EG + + K+ ++ K+ L +A K I + H K P
Sbjct: 339 ---KYEGL----KIWDANKVIVEDLKNNGSLIKAGK-ISHSYPHCWRCKGP--------- 381
Query: 423 VKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKAL 482
+M+ + IS +D N + K + +
Sbjct: 382 ----------------VMFRATPQWFIS----------------VDKNN--LRGKVLEEI 407
Query: 483 ARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTIS 542
++K YP + A++ +R+ G P+P ++ + + I
Sbjct: 408 KKVKWYPAWGETRITAMVQERPDWTISRQRVWGVPIP-----AVKCKDCGEVTLEPKVIE 462
Query: 543 RHINRLREEG-----RLDPEKLTPEFFDYIFLEEFSEEREK---ELEKKTGIPAEIIHEM 594
N ++E+G LD +L P F + E+ ++ +G E +
Sbjct: 463 HFANIVKEKGTDAWFELDVNELIPADFKCPACGSKNFEKTHDTLDVWMDSGCSWEAVIRS 522
Query: 595 KEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGF-GTLEGQKMSK 653
K E +P+D G D IF A + K + +GF +G+KMSK
Sbjct: 523 KGE---RFPVDLYLEGDDQHRGWFQSSIFLSTAKAGTAPF-KAVVTHGFIKDEQGRKMSK 578
Query: 654 SKGNVLNFIDAIEENGADVVRLYIMSLAEHD------SDFDWRRKEVGKLRRQLERFYEL 707
S GNV++ ++ + + GAD++RL++ S D + + + + KLR L
Sbjct: 579 SLGNVIDPMEIVNKYGADILRLWVASTDFFDNIRVGKNIIEQQVEVYRKLRNTLRYLLSN 638
Query: 708 ISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFR-----------TRTAVQWA 756
+ F E + +L +DKW L RL K IE T+ E F T +
Sbjct: 639 LYDFTEADLLPYEKLLPLDKWALGRLQKFIEQITQYYEGFEYSKVYNATVKYCTTELSAV 698
Query: 757 FYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEK--LGGEGF 814
+ I+ D R Y+ + + + L + + ++++AP P EE +++ L
Sbjct: 699 YLDILKD-RLYVEAKDSIYRRSAQTALHYILEALIKILAPIIPFTAEEAYQESHLKRYES 757
Query: 815 VSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAK 854
V L WPE E+ +E + E D + + +D+ + +E A+
Sbjct: 758 VHLEYWPEVRKEFIDEALLEEFDHLLLIRDDVLKALENAR 797
>sp|P36430|SYL_BACSU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437539|pir||D69650 leucine--tRNA ligase (EC
6.1.1.4) - Bacillus subtilis >gi|2293181|gb|AAC00259.1|
(AF008220) leucine tRNA synthetase [Bacillus subtilis]
>gi|2635516|emb|CAB15010.1| (Z99119) leucyl-tRNA
synthetase [Bacillus subtilis]
Length = 804
Score = 171 bits (428), Expect = 4e-41
Identities = 214/861 (24%), Positives = 328/861 (37%), Gaps = 180/861 (20%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIAR 65
+ IE+KWQ WLE K F D +++KFY FPY SG LHVGH YT D+++R
Sbjct: 6 KEIEKKWQTYWLENKTFAT--LDNNEKQKFYALDMFPYPSGAGLHVGHPEGYTATDILSR 63
Query: 66 FKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNI 125
KRMQGY+VL PMGW G P A L T DP
Sbjct: 64 MKRMQGYDVLHPMGWDAFGLPAEQYA------------------------LDTGNDPAVF 99
Query: 126 VKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRW 185
K + + GFS DW RE TT P + K+ +W FLKL EKG V W
Sbjct: 100 TKQNIDNFRRQIQALGFSYDWDREINTTD--PEYYKWTQWIFLKLYEKGLAYVDEVPVNW 157
Query: 186 DPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINP 245
P +GT L
Sbjct: 158 CPALGTVLA--------------------------------------------------- 166
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLS-FQDREIEVIEEFKGEKLI------------ 292
N + K +RGG K+ K++ + DR +E +EE + I
Sbjct: 167 NEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQRNWIGRSE 226
Query: 293 GKYVRNPVTG--DEVIILPAEFVDPDNATGVVMSV--PAHAPFDHVALEDLKRESEILVK 348
G +V + G D + PD G +V P HA +++ + K E +K
Sbjct: 227 GAHVHFAIDGHDDSFTVFTTR---PDTLFGATYTVLAPEHALVENITTAEQKEAVEAYIK 283
Query: 349 YDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKG 408
+I + E T ++ K + A+ V + EKL A Y G
Sbjct: 284 -EIQSKSDLERTDLAKTKTGVFTGAYAINPV---------NGEKLPIWIADYVLASYGTG 333
Query: 409 -IFKVPPYDGKPVQEVKE--LIAKEMMEKG-IAEIMYEFAEKNVISRFGN-----RAVIK 459
+ VP +D + + K L KE+++ G + E Y ++V S F N A+ K
Sbjct: 334 AVMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIEK 393
Query: 460 IIHDQWFIDYGNSEWKEKARKALARMKIYPETRRAQFEA---IIDWLDKKACA-RKVGLG 515
+I W + N E +K R++ + +R+ + +I W D + A + L
Sbjct: 394 VI--AWLEETKNGE-----KKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELP 446
Query: 516 TPLPWDPEWVIESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFD--YIFLEEFS 573
LP E +S + + ++GR + + P++ + FL
Sbjct: 447 LILPKTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTM-PQWAGSCWYFLRYID 505
Query: 574 EEREKELEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIF---- 629
+L E+ E W P+D G + HL + F H ++
Sbjct: 506 PHNPDQLASP------------EKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGV 553
Query: 630 --REEHWPKGIAVNGFGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDF 687
+E + K +KMSKSKGNV+N + + +GAD +RLY M + D+
Sbjct: 554 VPTKEPFQKLYNQGMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASI 613
Query: 688 DWRRKEVGKLRRQLERFYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEF 747
W + RR L+R + L F E + N K +EG + LE
Sbjct: 614 AWSESGLDGARRFLDRVWRL---FIEDSGELN--------------GKIVEGAGETLERV 656
Query: 748 RTRTAVQ-------WAFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPH 800
T ++ F + ++ L ++ + K ++ + +V+L++P PH
Sbjct: 657 YHETVMKVTDHYEGLRFNTGISQLMVFINEAYKATELPKEYM-----EGFVKLLSPVAPH 711
Query: 801 ICEELWEKLGGEGFVSLAKWP 821
+ EELWEKLG G ++ WP
Sbjct: 712 LAEELWEKLGHSGTIAYEAWP 732
>gb|AAK41179.1| Valyl-tRNA synthetase (valS) [Sulfolobus solfataricus]
Length = 842
Score = 169 bits (423), Expect = 2e-40
Identities = 223/908 (24%), Positives = 369/908 (40%), Gaps = 172/908 (18%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKK---FYITVAFPYLSGHLHVGHARTYTIPD 61
N + IEEKWQK WL + + + + ++ K F I P+ SG LH+GHA TI D
Sbjct: 45 NPKEIEEKWQKIWLSEEYWRDVFRFRDEDDKAPRFVIDTPPPFTSGELHMGHAYWVTIAD 104
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYK--VPEEILWTF 119
I RFKR++GYNVL P GW G P + + + + I +D + + + I WT
Sbjct: 105 TIGRFKRLEGYNVLLPQGWDTQGLP-------TELKVQYKLGIPKDNRQLFLQKCIEWTE 157
Query: 120 EDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKG 179
E +K KE IR G+ +W R Y T P + K I+ + + + I
Sbjct: 158 E--------MIKKMKEAMIRLGYRPEWERFEYKT-YEPKYRKIIQKSLIDMYKMNLIEMR 208
Query: 180 AHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVT 239
V W P T L ++ E IL Y IKF LKEG E + AT RPE +
Sbjct: 209 EGPVIWCPKCETALAQSEVGYLEKEGILAY--IKFPLKEGGEIV---IATTRPELLAATQ 263
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
+ +NP + YK L+GK P
Sbjct: 264 AIAVNP---------------------MDERYK-----------------NLVGKIALVP 285
Query: 300 VTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEI 359
+ EV I+ V+ + TG VM P +D+K + +KY++ +++ +
Sbjct: 286 IFNIEVKIISDADVEKEFGTGAVMISTYGDP------QDIKWQ----LKYNLPIKVIVD- 334
Query: 360 TYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKP 419
E+ + + D K+EQA + + KG
Sbjct: 335 -----------------EKGRIINTNGILDGLKIEQARNKMIELLKTKGYL-------VK 370
Query: 420 VQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKAR 479
V+++K + +E+ EF K I IK++ + K+K
Sbjct: 371 VEKIKHNVLSH-VERSDCLSPVEFLVKKQI-------YIKVL-----------DKKQKLL 411
Query: 480 KALARMKIYPETRRAQFEAIIDWLDKKA----CARKVGLGTPLPWDPEWVIESLSDSTIY 535
+ +MK P E DW+ R+ GTPLP+
Sbjct: 412 EEYKKMKFKPARMSYYLE---DWIKSIEWDWNITRQRIYGTPLPF--------------- 453
Query: 536 MAYYTISRHINRLREEG-RLDPEKLTPEFFDYIF----LEEFSEEREKELEKK-TGIPAE 589
+Y + H+ +EE +DP K +P L+ ++ + ++ T +
Sbjct: 454 --WYCENGHLVPAKEEDLPIDPIKTSPPLEKCPLCGSELKPVTDVADVWIDSSVTVLYLT 511
Query: 590 IIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNG--FGTLE 647
+E K F +P R G D+I L + F + + + + VNG G +
Sbjct: 512 KFYEDKNVFNRTFPASLRLQGTDIIRTWLFYTFFRTLMLANNVPFTT-VLVNGQVLGP-D 569
Query: 648 GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYEL 707
G +MSKSKGNV++ +D + + GAD +R+ ++ + D DF ++ V + L++ +
Sbjct: 570 GTRMSKSKGNVVSPLDRVNDFGADAIRMALLDASIGD-DFPFKWDIVKGKKMLLQKLWNA 628
Query: 708 ISQFAEYEAKENVE----LKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWA---FYSI 760
+ AK+ ++ L +DKW+L K + A E + +Q F+ I
Sbjct: 629 SRLVYPFIAKQRLDKPKSLHIVDKWILQEHKKFVTKAINAYENYDFYLVLQELYNYFWEI 688
Query: 761 MND--LRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKL-GGEGFVSL 817
+ D L R D+ AK + R + DI + L+ P PHI EE++ +L G + V L
Sbjct: 689 VADEYLEMIKHRLFDDDNSAKYTIQRIIRDI-IILLHPIAPHITEEIYSRLFGHKKSVLL 747
Query: 818 AKWPEPVDEWWNEEVEVEEDFIK---SLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVY 874
+ P+ D N+ ++ + IK SLI ++I + +P +Y + + V
Sbjct: 748 EELPKVDDIEENKRIDELGEVIKKTNSLIRS-EKIKNRLSMNTPVSVKLYASKQ----VI 802
Query: 875 EVVAEKRE 882
E++ E ++
Sbjct: 803 ELINEVKD 810
>gb|AAF65673.1|AF208389_1 (AF208389) isoleucyl-tRNA synthetase [Methanosarcina barkeri]
Length = 1058
Score = 165 bits (414), Expect = 2e-39
Identities = 198/899 (22%), Positives = 361/899 (40%), Gaps = 150/899 (16%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N IE+K + W ++ + + + K+ + PY +GH+H+G A I D I
Sbjct: 10 NAEQIEKKITQLWKDSDAYRKTREHRKTGKRLFFVDGPPYTTGHIHLGTAWNKIIKDSIL 69
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERI----KNRDPHTIWIYRDVYKVPEEILWTFE 120
R+ M N+L GW + G PI E + +D + + + K E + +
Sbjct: 70 RYYSMNNRNILERPGWDMHGLPIEVKVEGVLGFKSKKDIESFGVENFIEKCKEFAINQKQ 129
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
+ E F R G + W + T L + + W + EK + G
Sbjct: 130 EMT-----------EQFQRLGVWMQWEAPYMT--LKDDYIEAAWWTLKQASEKNLLDVGK 176
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
V W P T + D ++ E YV KF++K G+E ++ T P T+
Sbjct: 177 RSVNWCPRCETAIADSEVEYAERTDPSIYV--KFKIK-GEENTFIVIWTTTPWTIPANVA 233
Query: 241 MWINPNATYVKAK-VKRGGKEETWIISKEAAYKLSFQDREI--EVIEEFKGEKLIGKYVR 297
+ ++P Y K + +++ G +E I + + + Q R + EV+E GE L
Sbjct: 234 VAVHPGFEYSKFRAIRQDGSDEILIAATDLIENVLRQGRYVDYEVLETMLGEDLTKLEYE 293
Query: 298 NPVTGDEVI--------ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKY 349
+PV GD V I A++V +N TG V P H D + VKY
Sbjct: 294 SPV-GDLVPVQNEIKHGIYLADYVTAEN-TGCVHIAPGHGMDDF----------NVGVKY 341
Query: 350 DIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGI 409
++ P + V G +++ E
Sbjct: 342 NL----------------------PILCPVGPNGAYTEEAGE------------------ 361
Query: 410 FKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGN-----RAVIKIIHDQ 464
Y GK V+E ++ +++ ++ AE V R+G+ +I + +Q
Sbjct: 362 -----YAGKNVREANPIVIEDLRKRNRL-----LAEGTVTHRYGHCWRCKTPIIYLATEQ 411
Query: 465 WFIDYGNSEWKEKARKALARMKIYPE-TRRAQFEAIIDWLDKKACARKVGLGTPLPWDPE 523
WF+ ++ K+K +A+ + YPE A+F ++ +R+ G P+P
Sbjct: 412 WFLKV--TDIKDKMLEAIDAVDWYPEWAGSARFRTWVEGARDWCISRQRYWGMPIP---V 466
Query: 524 WVIESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKK 583
W + + I L + G +L + D + + +K +E
Sbjct: 467 WKCKKCGKLEV------IGTKAELLEKSGAGSDVELHRPYVDKLTIPCECGGEKKRVEDV 520
Query: 584 TGIPAEI---------IHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHW 634
+ + + +E+F+ W+P D+ G D + + F +
Sbjct: 521 FDVWFDSAVASWATLKFPQTREQFDEWWPADFITEGHDQTRGWFYSQLGASMVGFGRAPY 580
Query: 635 PKGIAVNGFGTLE--GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRK 692
K + ++GF TL+ G+KMSKS GNV++ ID I++ GAD +R Y++S + D + ++
Sbjct: 581 -KSVLMHGF-TLDAGGKKMSKSLGNVVSPIDVIDKYGADTLRAYVLSSSAPWDDLKFNQE 638
Query: 693 EVGKLRRQLERFYELISQFAEYEAKENVE------------LKTIDKWLLHRLNKAIEGT 740
EV + R + + + Y A +N + L+ D+W+L R+ ++
Sbjct: 639 EVENVHRSINILWNVFRFPLPYMALDNFDPLKVSLDSVKDALREEDRWILSRIQSVVKAV 698
Query: 741 TKALEEFRTRTAVQWAFYSIMNDL-RWYMRRTEGR-----DDEAKRFVLRKLADIWV--- 791
+A+ + AV+ + DL RWY++ R DD K R L +++V
Sbjct: 699 DEAMSGYFLHKAVREILEFTLEDLSRWYIQLIRPRTWTEADDPDKLAAYRVLYEVYVTLT 758
Query: 792 RLMAPFTPHICEELWEKL------GGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIE 844
+L++PF P++ EE+++ L V + WP+ + + + E+E +S++E
Sbjct: 759 KLISPFMPYLAEEMYQNLIRNVDPNALESVHMCDWPKVNEAYLDPELEAAMSTARSIVE 817
>gi|11498241 isoleucyl-tRNA synthetase (ileS) [Archaeoglobus fulgidus]
>gi|3122898|sp|O29622|SYI_ARCFU ISOLEUCYL-TRNA
SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437551|pir||A69329 probable isoleucine--tRNA ligase
(EC 6.1.1.5) - Archaeoglobus fulgidus
>gi|2649988|gb|AAB90608.1| (AE001061) isoleucyl-tRNA
synthetase (ileS) [Archaeoglobus fulgidus]
Length = 1018
Score = 159 bits (398), Expect = 1e-37
Identities = 230/939 (24%), Positives = 385/939 (40%), Gaps = 158/939 (16%)
Query: 12 KWQKRWLEAKVF----EPNIKDKPKEK---KFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
K+ + +E+++F + +I K KEK KFY PY +G +H+G A + D I
Sbjct: 5 KYSPKDVESEIFKFWEDNDIYRKVKEKGGRKFYFVDGPPYTTGRIHLGTAWNKVLKDTIL 64
Query: 65 RFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R+KRM G+ GW + G PI V + + + R I + + + + I E +
Sbjct: 65 RYKRMMGFAPTDTPGWDMHGLPIEVKVEQELGFRTKRDI----ESFGIDKFI----ERCM 116
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
N A E F +DW + T + + + E+G + + V
Sbjct: 117 NYALANKDAMTEQFKSLAVWMDWENPYMTIKA--EYMNAAWFAIKRAHERGLLERKKMVV 174
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWI 243
W T L D ++ ++ YV KF +K G++ Y+ T P T+ + +
Sbjct: 175 NWCHRCETALADAEVEYWDEEDPSIYV--KFPVK-GEKDTYIVIWTTTPWTLPANMAVAV 231
Query: 244 NPNATYVKAKVKRGGKEETWIISKEAAYK-LSFQDREI-EVIEEFKGEKLIGKYVRNPVT 301
+P+ Y K + + GK E I++KE A L D + EV+E + GE L G +P+
Sbjct: 232 HPSLEYAKFRAVKDGKVEYLILAKELADSVLGKGDYDSWEVVETYLGEDLEGLEYEHPLA 291
Query: 302 GDEVI-------ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPR 354
+ + + A+FV +N TG V P H D+ +L E + V +D R
Sbjct: 292 DEVPLQKNWKHQVFFADFVTAEN-TGCVHIAPGHGVEDY----ELGVEKGLEVFNPVDDR 346
Query: 355 IVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPP 414
+Y E K
Sbjct: 347 --------------------------------------------GVYTEEAGK------- 355
Query: 415 YDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGN--RAVIKIIH---DQWFIDY 469
Y GK V+E + I ++ K + AE+ ++ R+G+ R II+ +QWFI
Sbjct: 356 YAGKHVKEANDDIIDDLYRKDLL-----LAEERIVHRYGHCWRCKTPIIYRATEQWFIKI 410
Query: 470 GNSEWKEKARKALARMKIYPE-TRRAQFEAIIDWLD--KKAC-ARKVGLGTPLPWDPEWV 525
SE K++ + + ++ PE A+F+ DW+ K C +R+ G P+P W+
Sbjct: 411 --SELKDEMLEEIDKVMWIPEWAGSARFK---DWVSNAKDWCISRQRYWGIPIP---VWI 462
Query: 526 IESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIF-------LEEFSEEREK 578
E + + + IN + E LD + P+ F + + +
Sbjct: 463 CEKCGEMKVVGS-------INEIEWENDLDLHR--PKIDAVTFSCQCGGVMRRVPDVFDV 513
Query: 579 ELEKKTGIPAEIIHEM-KEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKG 637
+ I + + K++FE +P D+ G D + V F + + K
Sbjct: 514 WFDSGVASWGSIAYPLRKDKFEELWPADFITEGHDQTRGWFYSQLGTSVVCFDKAPY-KA 572
Query: 638 IAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAE-HDSDFDWRRKEVG 695
+ ++GF E G+KMSKS GNV+ + + + G D RLY++ A D F W +E
Sbjct: 573 VLMHGFTLDEQGRKMSKSLGNVVEPEEVVGQIGVDGFRLYVLYSAPWEDLRFSW--EEAR 630
Query: 696 KLRRQLE------RFYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRT 749
+ R L RF Y E ELK D+W+L RL I+ +A+E ++
Sbjct: 631 NINRMLNVVWNAVRFAHTYMSLDNYSFGEKGELKIEDRWILSRLESFIKEANEAMEGYQV 690
Query: 750 RTAVQWAFYSIMNDL-RWYM-----RRTEGRDDEAK---RFVLRKLADIWVRLMAPFTPH 800
V+ F + D RWY+ R E RD +K + + ++ D +R +APF P
Sbjct: 691 HRVVRAFFDFFVEDFSRWYIQIIRPRVWEERDSPSKLAAYYTMFRVIDRSLRAIAPFAPL 750
Query: 801 ICEELWE---KLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIES 857
I E ++ K EG S+ ++E+ EVE+ + +++ ++ KEI+E A
Sbjct: 751 IAEWFYQHVVKEFREGEESIF-----MEEYSTAEVEMIDGELEAAMKVAKEIVEAAANAR 805
Query: 858 PKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEI 896
K + +W + E+V E K A M +E I
Sbjct: 806 NK-----AKRKLRWPLRELVIESGSEKVRKAVEMLEETI 839
>sp|P46213|SYI_THEMA ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437563|pir||B72263 isoleucine--tRNA ligase (EC
6.1.1.5) - Thermotoga maritima (strain MSB8)
>gi|4981921|gb|AAD36431.1|AE001790_3 (AE001790)
isoleucyl-tRNA synthetase [Thermotoga maritima]
Length = 919
Score = 157 bits (393), Expect = 6e-37
Identities = 200/885 (22%), Positives = 369/885 (41%), Gaps = 141/885 (15%)
Query: 11 EKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQ 70
E+W+K L V E K KP F + PY +GH+H+G A + D++ ++K M+
Sbjct: 29 EEWEKMDLYNYVLEQR-KGKPL---FVLHDGPPYANGHIHIGTALNKILKDIVVKYKTMR 84
Query: 71 GYNVLFPMGWHITGSPI-----VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNI 125
GY + GW G PI + E+IK P ++ K EE F D
Sbjct: 85 GYRAPYVPGWDTHGLPIEHRVSQELGEKIKEMSP------AEIRKKCEEFALRFVD---- 134
Query: 126 VKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRW 185
+E F R G DW + T L P + I F L E+G + + + W
Sbjct: 135 ------IQREEFKRLGVRGDWENPYIT--LKPDYEVKILDVFKTLVEQGNVYRSLKPIYW 186
Query: 186 DPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINP 245
P T L + ++ + YV KF KE D ++ T P T+ + ++P
Sbjct: 187 CPRCRTALAEAEIEYHDHKSPSIYV--KFRSKE-DPNFFIVIWTTTPWTLPANVGIALHP 243
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIE---VIEEFKGEKLIGKYVRNPVTG 302
+ Y KV EE W+I+ + S ++ I+ V+E+ KG+ L GK +P+
Sbjct: 244 DYEYSVVKV----GEEKWVIATDLLDAFS-KETGIDCSNVVEKIKGKDLEGKEFVHPIFD 298
Query: 303 DEVI-ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITY 361
D ++ A++V + TG V P H D++ V+Y +
Sbjct: 299 DRTSRVILADYVSLETGTGCVHIAPGHGEEDYIYGH---------VQYGL---------- 339
Query: 362 ISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQ 421
P V V + G E+A K +KG+F ++
Sbjct: 340 ------------PIVSPVDEEG-------RFTEEAGK-------YKGMF---------IE 364
Query: 422 EVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKA 481
+ E+I +++ KGI VI +QWFI ++ ++K +
Sbjct: 365 DANEVIIEDLKRKGILVHASSITHSYPHCWRCKGPVIFRATEQWFISVDHNNLRQKVLEE 424
Query: 482 LARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTI 541
+ ++K PE R + ++++ +R+ GTP+P ++ + + I
Sbjct: 425 IDKVKWIPEWGRNRIRSMVEERPDWCISRQRVWGTPIP-----AVKCKECGEVVLDPKVI 479
Query: 542 SRHINRLREEG-----RLDPEKLTPEFFDYIFLEEFSEEREKELEK-----KTGIPAEII 591
+ + +EG + E+L PE D++ + EK L+ +G E I
Sbjct: 480 EHFMKIVEKEGTNAWFEKEVEELIPE--DFVCPKCGKRSFEKMLDTLDVWIDSGASFEYI 537
Query: 592 HEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWP-KGIAVNGF-GTLEGQ 649
+E ++ +PLD G D IF +A+ + P K + +GF +G+
Sbjct: 538 TTKRE--DHPFPLDMYLEGSDQHRGWFHSSIF--LAVAKRGSAPYKEVLTHGFIKDEQGR 593
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGK----LRRQLERFY 705
KMSKS GNV++ ++ +E+ GA+++RL++ S +++ +D + V + R+ F
Sbjct: 594 KMSKSLGNVVDPMEVVEKYGAEILRLWLAS-SDYFNDIKISMRIVEQQTEVYRKIRNTFR 652
Query: 706 ELISQFAEYEAK----ENVELKTIDKWLLHRLNKAIEGTTKALEEFR-----------TR 750
L+ +++ + + +L TID+W L RL + I+ T+ + +
Sbjct: 653 FLLGNLEDFDPELDRVPHEKLLTIDRWALGRLQEIIKRATEYYDSYEFSKVYNLVVKYCT 712
Query: 751 TAVQWAFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLG 810
T + + ++ D R Y+ + + + V+ ++ ++++AP EE++ L
Sbjct: 713 TELSSLYLDVVKD-RLYVEAKDSIYRRSAQTVMHEILISLMKILAPIMTFTMEEVYSHLH 771
Query: 811 GEG----FVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIE 851
+ V WPE +E+ + ++ + + + S+ ED+ + +E
Sbjct: 772 EKDRKYKTVQAEYWPEYREEFIDRKLMEDFEKLLSIREDVLKALE 816
>gb|AAF76435.1|AC015445_2 (AC015445) Contains similarity to leucyl tRNA synthetase from Homo
sapiens gb|D84223. [Arabidopsis thaliana]
Length = 843
Score = 155 bits (388), Expect = 2e-36
Identities = 105/361 (29%), Positives = 163/361 (45%), Gaps = 67/361 (18%)
Query: 9 IEEKWQKRWLEAKVFEPNIKD---KPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIAR 65
IE +K W + VF +D KP EK F+ T FPY++G+LH+GHA + + D +
Sbjct: 17 IEVAVRKWWEDEDVFRAESRDHLPKPGEK-FFSTFPFPYMNGYLHIGHAFSLSKVDFASA 75
Query: 66 FKRMQGYNVLFPMGWHITGSPIVGIAERIKNR-----DPHTI------------------ 102
+ R++G NVL P G+H TG PI A+++ DP
Sbjct: 76 YHRLRGANVLLPFGFHCTGMPIKASADKLSREILQFGDPPVFPAQDNLAPQVHEEGSDTP 135
Query: 103 -----------------------WIYRDVYKVPEEILWTFEDPVNIVKYFMKAAKETFIR 139
W + + + + F DP + YF A E
Sbjct: 136 ALTGQFKGKKSKVAAKSGGQVYQWQIMRSFGLTDSEIARFRDPDEWLYYFPPLAVEDLKA 195
Query: 140 AGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLM 199
G DW R F TT + P F F+ WQ KLK G IVK + P+ P DHD
Sbjct: 196 YGLGCDWRRSFVTTDVNPFFDAFVRWQMRKLKALGKIVKDCRYTIFSPLDRQPCADHDRA 255
Query: 200 EGEDVPILEYVIIKFELKE---------GDETIYLPAATLRPETVYGVTNMWINPNATYV 250
GE V EY +IK E+ + + ++L AATLRPET+YG TN W+ P+ Y
Sbjct: 256 TGEGVQPQEYTLIKMEVVKPFPLKLSPLEGKRVFLAAATLRPETMYGQTNAWVLPDGKYG 315
Query: 251 KAKVKRGGKEETWIISKEAAYKLSFQD-----REIEVIEEFKGEKLIGKYVRNPVTGDEV 305
++ + + +I+++ +A ++Q+ ++ + E G LIG +++P++ +E+
Sbjct: 316 AYEI---SETDVFILTERSALNRAYQNFSKNPKKPSCLVELTGYDLIGLPLKSPLSVNEI 372
Query: 306 I 306
I
Sbjct: 373 I 373
Score = 148 bits (370), Expect = 3e-34
Identities = 138/504 (27%), Positives = 219/504 (43%), Gaps = 99/504 (19%)
Query: 471 NSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPE-WVIESL 529
N EW++ A + L++M +Y E R FE + WL + AC+R GLGT +PWD E +++ESL
Sbjct: 384 NKEWRKMAEECLSKMNLYSEETRHGFEHTLSWLIQWACSRSFGLGTRIPWDNERFLVESL 443
Query: 530 SDSTIYMAYYTISR--HINRLREEGR--LDPEKLTPEFFDYIFLEEFSEEREKELEKKTG 585
SDS++YMAYYT++ H + + + + P+++ E ++Y+F + K T
Sbjct: 444 SDSSLYMAYYTVAHIFHDGDMYKGSKSLIRPQQMNDEVWEYLFC-------DGPYPKSTD 496
Query: 586 IPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGT 645
IP+ ++ +MK+EF+YWYPLD R
Sbjct: 497 IPSAVLSKMKQEFDYWYPLDLR-------------------------------------- 518
Query: 646 LEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSD----FDWRRKEVGKLRRQL 701
S GN AIEE A R + + D F+ + +L +QL
Sbjct: 519 --------STGNFRTLRQAIEEFSATATRFSLADAGDGVDDANFVFETANAAILRLVKQL 570
Query: 702 ERFYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIM 761
E E ++ AE + DK + +N AI T KA +E R A++ Y +
Sbjct: 571 EWMEEKLA--AESSLRTGPPSTYADKVFENDINIAIRLTEKAYKECLFREALKNGVYDLQ 628
Query: 762 NDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEK-LGGEGFVSLAKW 820
Y R + G D+ ++ D+ RL+ P P E +W K L EG V A W
Sbjct: 629 AARDEY-RNSCGSDENMNHDLILNFMDVQTRLIEPICPQFAEYVWRKLLKKEGSVVTAGW 687
Query: 821 PEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEV--AKIESPKRAYIYTAPEWK-------- 870
P NE V + K L + I + ++ +K + K A + AP K
Sbjct: 688 PTS-----NEPDLVLKSANKYLQDSIVLMRKLLGSKKAAKKGAQVTAAPAGKAHCLKFLQ 742
Query: 871 ----WKVY------EVVAEKREF--KSAMAELMKDEEIRKHGKEVAKL-VQAIIKERAFD 917
+ Y E++AE +E K AE + ++ KE + +QA+ F
Sbjct: 743 SKFDQQTYRFAPDAEIIAELKEILQKDGQAENIYMPFVKFKKKEAISIGIQALNLRLPF- 801
Query: 918 VKRIDEEKVLRESKDFLEKELGLE 941
E +VL+ + D ++++LGLE
Sbjct: 802 ----GEIEVLKSNMDLIKRQLGLE 821
>sp|O27428|SYI_METTH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437550|pir||H69049 isoleucine--tRNA ligase (EC
6.1.1.5) - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2622484|gb|AAB85852.1| (AE000900)
isoleucyl-tRNA synthetase [Methanobacterium
thermoautotrophicum]
Length = 1044
Score = 154 bits (386), Expect = 4e-36
Identities = 245/1014 (24%), Positives = 410/1014 (40%), Gaps = 202/1014 (19%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IEEK Q W E ++E + + ++ PY SG +H+G A + D RFK
Sbjct: 15 IEEKVQSFWEERDIYERVKELREDRPRYSFLDGPPYCSGRIHLGTAWNKIMKDTYLRFKS 74
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M+G+NV GW G PI E + R + ++I E+ VN +
Sbjct: 75 MKGFNVRRQPGWDTHGLPIEHKVEGLLG--------VRSKKDIEDKI--GIEEFVNKCRE 124
Query: 129 FMKAAKET----FIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
F K F R G +DW + T P + + W + EK +V+ +
Sbjct: 125 FAVENKAVMTGQFQRLGVWMDWDDPYVTFD--PAYMESCWWTLKRAHEKDLLVRDLRVIT 182
Query: 185 WDPVVGTPLG--DHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMW 242
W P T L + D + ED I +KF + GD I + T P T+ +
Sbjct: 183 WCPRCETALALAEIDYHDKEDPSIY----VKFPVS-GDTHILVWTTT--PWTLPANMAVA 235
Query: 243 INPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTG 302
++P+ Y A++ ET+I+++ K+ + E E+++ KG +L G R+P+
Sbjct: 236 VHPDFEYAYARLDG----ETYIMAEALVEKVLGE--EAEILKRVKGTELEGLTYRHPLDD 289
Query: 303 D-------EVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRI 355
+ E ++ + V TG V + P H P D EI KY ++
Sbjct: 290 EVPLHREIEHRVILGDHVTLTEGTGCVHTAPGHGPEDF----------EIGKKYGLE--- 336
Query: 356 VEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPY 415
+ V + GI + E+A K Y
Sbjct: 337 -------------------VICPVDEAGIFT-------EEAGK----------------Y 354
Query: 416 DGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFG-----NRAVIKIIHDQWFIDYG 470
G+ V++ E I ++ KG+ + R+G +I + +QWF+
Sbjct: 355 SGRFVKDADEDIIADLRSKGLL-----LKAGTISHRYGFCWRCKTPIIYLATEQWFLKI- 408
Query: 471 NSEWKEKARKALARMKIYP----ETR-RAQFEAIIDWLDKKACARKVGLGTPLPWDPEWV 525
+E K+K + L R++ P E+R R E DW +R+ G P+P W+
Sbjct: 409 -TEIKDKMLRELDRVQWVPSWAGESRFRNWIENARDW----TISRQRYWGIPIPI---WI 460
Query: 526 IESLSDSTIYMAYYTISRHINRLRE---EGRLDPEKLTPEFFDYIFLE--EFSEEREK-- 578
E + + I+ LRE EG L+ + + D I LE E ++
Sbjct: 461 CEECDSIHVVGS-------IDELRELAVEGELEGDFIHRPHVDRIVLECGECGGRMKRTP 513
Query: 579 ---ELEKKTGIPA-EIIHEMKEE--FEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREE 632
++ +G+ +H E F W+P D+ G D + V E
Sbjct: 514 DVLDVWIDSGVAGWAALHYPSETELFREWFPYDFITEGHDQTRGWFYSQLGCGVIALDEV 573
Query: 633 HWPKGIAVNGFGTL--EGQKMSKSKGNVLNFIDAIEENGADVVRLYIM--SLAEHDSDFD 688
+ + + ++GF TL EG+KMSKS GNV+ D IE+ GADV+R Y++ + D F
Sbjct: 574 PYRR-VLMHGF-TLDEEGRKMSKSLGNVVEPEDVIEKYGADVLRFYLLWENKPWEDLKFV 631
Query: 689 W-RRKEVGKLRRQLERFYELISQFAEYE-------AKENVELKTIDKWLLHRLNKAIEGT 740
W + V K+ L Y + + + + E++ + D+W+L R+N
Sbjct: 632 WDELRNVNKMFNILWNVYVFATTYMSLDRFQPGDHSAEDLSFRDEDRWILSRINSVALKV 691
Query: 741 TKALEEFRTRTAVQWAFYSIMNDL-RWYMRRTEG-----RDDEAKRFVLRKLADIWVRL- 793
T+A+E A + I+ DL RWY+R RDD K L + L
Sbjct: 692 TEAIENLHFHRATREIHDFIVEDLSRWYIRLIRSRTWIERDDPDKLAAYHTLYTVLKTLI 751
Query: 794 --MAPFTPHICEELWEKL--GGEGFVSLAKWPEPVD--EWWNEEVEVEEDFIKSLIEDIK 847
++P PH+CE++++ L G E PE + +W +E V+ +++ ++ ++
Sbjct: 752 VTLSPMAPHVCEDIYQNLVRGAE-----PDSPESIHMLDWILDEGAVDSQ-LEADMDIVR 805
Query: 848 EIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHGKEVAKLV 907
EIIE RA + +W V E+V + +DE + K A+ +
Sbjct: 806 EIIEAC-----ARARDTARYKLRWPVREMVV-----------VSEDEGVLK----AAESL 845
Query: 908 QAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPE-EDKGGKKRQAIPL 960
+ +I E+A K ++ S +F + +++I P G + RQ IPL
Sbjct: 846 KNVIAEQA-------NAKSIKTSTEFPD----MKIIARPNPATLGPRLRQDIPL 888
>sp|Q58357|SYI_METJA ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|2129087|pir||C64418 isoleucine--tRNA ligase (EC
6.1.1.5) - Methanococcus jannaschii
>gi|1591614|gb|AAB98949.1| (U67538) isoleucyl-tRNA
synthetase (ileS) [Methanococcus jannaschii]
Length = 1039
Score = 154 bits (385), Expect = 5e-36
Identities = 209/895 (23%), Positives = 359/895 (39%), Gaps = 153/895 (17%)
Query: 4 LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
+NFR +++K +K W E +++ K + K+FY PY SG +H+G A I D
Sbjct: 7 VNFRELDKKIKKFWEENDIYQKVKKKNERNKEFYFVDGPPYCSGAIHLGTAWNKIIKDTY 66
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDP--HTIWIYRDVYKVPEEILWT 118
RFKRMQGYNVL GW + G PI E IKN+ I + + + K E L
Sbjct: 67 LRFKRMQGYNVLDKAGWDMHGLPIEVKVENEFGIKNKKEIETKIGVKQFIEKCKEFALKH 126
Query: 119 FEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIE--WQFLKLK-EKGY 175
E ++ F G +DW + P +++E W LK+ EKG
Sbjct: 127 KE-----------IMEKQFKNLGVWLDWENAY-----MPITKEYMEIGWWTLKVAHEKGL 170
Query: 176 IVKGAHRVRWDPVVGTPLGDHDLMEGEDVPILE-YVIIKFELKEGDETIYLPAATLRPET 234
+ + V W P T L +H++ GE + + V +KF L +E Y+ T P T
Sbjct: 171 LTRDLRVVYWCPRCETALAEHEV-RGEYKEVYDPSVYVKFRLAN-EENTYIVIWTTTPWT 228
Query: 235 VYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGK 294
+ + ++P+ Y +V+ K+E WII+++ ++ + ++ I+ +K +I K
Sbjct: 229 LVANLAVTVHPDYDYAYVEVEFDDKKEVWIIAEKLVEEVINKAKKFHNIKNYK---IIKK 285
Query: 295 YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPR 354
+ G + I H LE+ +R+ E +
Sbjct: 286 VKGKELEGIKYI--------------------------HPLLEENERQKEFAELENAHTV 319
Query: 355 IVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPP 414
I+ E + LEG V ++D E ++ IY +G +
Sbjct: 320 ILGEH-----VTLEG-----GTGLVHTAPGHGEEDFEVGKKYNLPIYSPIDDEGKYVEGK 369
Query: 415 YDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEW 474
+ G V++ I + + KG+ + ++ +QWF++ S+
Sbjct: 370 WKGVFVKDADAEIIETLKNKGLLVYAGKIKHSYPHCWRCKTPLLFRATEQWFLEI--SKI 427
Query: 475 KEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTI 534
K+ + ++ P ++ + ++ +R+ G P+P WV E +
Sbjct: 428 KDNIIEHAKTVQWIPHWVETRYINGVKFVGDWNISRQRYWGIPIP---VWVCEKCGKYIV 484
Query: 535 YMAYYTISRHINRLREEGRLDP------------------EKLTPEFFDYIF---LEEFS 573
+ + + E G ++ K P+ D F L ++
Sbjct: 485 VGSVEELEEKMINKDEVGEINDLHKPTVDKIKLRCECGGEMKRVPDVLDVWFDSGLAPYA 544
Query: 574 EEREKELEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEH 633
KEL+K A+ I E ++ W+ + L+ +FN +
Sbjct: 545 SIGVKELKK-----ADFITEGHDQVTKWF----------YSQHALSAIVFNDIPY----- 584
Query: 634 WPKGIAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRK 692
K ++GF E G KMSKS GNV+N D +E+ GAD++R Y++S + D +
Sbjct: 585 --KKCLMHGFTLDEHGDKMSKSLGNVVNPDDVVEKYGADLLRFYLLSANKVWEDLRFVWS 642
Query: 693 EVGKLRRQLERFYELISQFAEYEAKENVE--------LKTIDKWLLHRLNKAIEGTTKAL 744
E+ + + Y +N + LK D+W++ R+N + + L
Sbjct: 643 EMDDVLSLFNTLWNAYMFAVNYMVLDNFKPDEKYFEYLKDEDRWIVSRINSVAKIAIENL 702
Query: 745 E--EFRTRTAVQWAFYSIMNDL-RWYMR----RTEGRDDEAKR--------FVLRKLADI 789
E F T T F I+NDL RWY+R RT D+A + +VL KLA I
Sbjct: 703 EVPYFHTYTWTLKDF--ILNDLSRWYIRLIRDRTWKEKDDADKLAAYQTLYYVLLKLATI 760
Query: 790 WVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIE 844
+AP PH E +++ L K + + + ++EV+E+FI +E
Sbjct: 761 ----LAPVAPHTAEAIYQNL---------KTEDMEESIFMNKIEVDEEFIDEELE 802
>sp|Q45477|SYI_BACSU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437553|pir||H69643 isoleucine--tRNA ligase (EC
6.1.1.5) ileS - Bacillus subtilis
>gi|2633916|emb|CAB13417.1| (Z99112) isoleucyl-tRNA
synthetase [Bacillus subtilis]
Length = 921
Score = 152 bits (380), Expect = 2e-35
Identities = 197/878 (22%), Positives = 354/878 (39%), Gaps = 121/878 (13%)
Query: 14 QKRWLEAKVF---EPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQ 70
QK+W E ++ + KD+PK F + PY +G +H+GHA + D I R+K M
Sbjct: 28 QKKWEEEDIYRLVQERTKDRPK---FVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMS 84
Query: 71 GYNVLFPMGWHITGSPIVGIAERIK--NRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
GYN + GW G PI + K NR ++ +R K+ EE W
Sbjct: 85 GYNAPYVPGWDTHGLPIETALTKNKKVNRKEMSVAEFR---KLCEEYAWK---------- 131
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
++ +E F R G DW + T L P + F ++ ++GYI KG V W P
Sbjct: 132 QIEGQREQFKRLGVRGDWENPYVT--LKPEYEAQQIRVFGEMAKRGYIYKGLKPVNWSPS 189
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETI----YLPAATLRPETVYGVTNMWIN 244
+ L + ++ E +D + + F +K+G + + T P T+ + ++
Sbjct: 190 SESALAEAEI-EYQDKRSAS-IYVAFGVKDGKGVLENGERIIIWTTTPWTIPANLGISVH 247
Query: 245 PNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDE 304
P+ Y V + + A F + EV KG+ L +P+ G +
Sbjct: 248 PDLEYSVIAVGEDRFVVASALVENVASACGFD--QYEVTRTVKGKDLENIIAEHPLYGRD 305
Query: 305 VIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISL 364
+++ E V D TG V + P H D + I KY +D
Sbjct: 306 SLVMLGEHVTTDAGTGCVHTAPGHGEDDFI----------IGQKYGLD------------ 343
Query: 365 IKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQEVK 424
+ V + G+ + + P ++G +
Sbjct: 344 ----------VLCPVDEKGVMTS-----------------------EAPGFEGMFYDDAN 370
Query: 425 ELIAKEMMEKGIAEIMYEFAEKNVISRF-GNRAVIKIIHDQWFIDYGNSEWKEKARKALA 483
+ I +++ EKG A + EF + + + I QWF +++ A+
Sbjct: 371 KAITQQLDEKG-ALVKLEFITHSYPHDWRTKKPTIFRATAQWFASI--KDFRSDLLDAIK 427
Query: 484 RMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP-WDPEWVIESLSDSTIYMAYYTIS 542
K PE + ++ +R+ G P+P + E ++D TI
Sbjct: 428 ETKWVPEWGEQRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFR 487
Query: 543 RHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEK---KTGIPAEIIHEMKEEFE 599
+H + + E + + L PE F + + +E+++ +G + + E +++
Sbjct: 488 QHGSNIWFE--KEAKDLLPEGFTHPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLV 545
Query: 600 YWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFG-TLEGQKMSKSKGNV 658
P D G D + VA+ + + KG+ +GF EG+KMSKS GNV
Sbjct: 546 --RPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPY-KGVLSHGFALDGEGRKMSKSIGNV 602
Query: 659 LNFIDAIEENGADVVRLYIMSLAEHDSDF---DWRRKEVGKLRRQLERFYELI-SQFAEY 714
+ +++ GAD++RL++ S+ ++ +D D K+V ++ R++ + + ++
Sbjct: 603 VVPAKVMKQLGADILRLWVSSV-DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDF 661
Query: 715 EAKENV----ELKTIDKWLLHRLNKAIEGTTKALEEFRTR----------TAVQWAFYSI 760
+ K N +L+ +D+++L +LNK I+ KA +E+ T +FY
Sbjct: 662 DPKTNAVAVEDLREVDQYMLIKLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLD 721
Query: 761 MNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLG--GEGFVSLA 818
Y+ + D + + V + V+L AP PH +ELW L E V L
Sbjct: 722 FAKDIVYIEHADHPDRRSMQTVSYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLT 781
Query: 819 KWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIE 856
PE + +E E + D +L +D+ + +E A+ E
Sbjct: 782 DMPETITVPNSEATEEKFDRFMALRDDVLKALETARNE 819
>dbj|BAB07000.1| (AP001518) leucyl-tRNA synthetase [Bacillus halodurans]
Length = 806
Score = 151 bits (378), Expect = 3e-35
Identities = 139/468 (29%), Positives = 195/468 (40%), Gaps = 100/468 (21%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIAR 65
R IE KWQK W E K F+ +D+ +EK FY FPY SG LHVGH YT D+++R
Sbjct: 6 REIESKWQKYWEENKTFKTE-EDETREK-FYALDMFPYPSGAGLHVGHPEGYTATDILSR 63
Query: 66 FKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNI 125
KRMQGYNVL PMGW G P A D P E E +N
Sbjct: 64 MKRMQGYNVLHPMGWDAFGLPAEQYAI--------------DTGNSPAEFT---EKNINT 106
Query: 126 VKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRW 185
+ +K+ GFS DW RE TT P + K+ +W F++L KG V W
Sbjct: 107 FRRQIKSL-------GFSYDWDREVNTTD--PDYYKWTQWIFIQLYNKGLAYIDEVAVNW 157
Query: 186 DPVVGTPLGDHDLMEGED----------------VPILEY-------------------- 209
P +GT L + ++++G+ + I EY
Sbjct: 158 CPALGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITEYADRLLEDLEELDWPESIKDM 217
Query: 210 ----------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGK 259
+ F + D+TI T RP+T++G T M + P V A K
Sbjct: 218 QRNWIGRSEGAEVTFSVDGHDDTI--TVFTTRPDTLFGATYMVLAPEHKLVDAITTSEQK 275
Query: 260 EETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNAT 319
+ KE A K D E + + K G Y NPV G++V I A++V T
Sbjct: 276 QAVESYKKEVATK---SDLERTELAKEKTGVFTGAYAINPVNGEKVPIWIADYVLVSYGT 332
Query: 320 GVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGY-GEFPAVEE 378
G +M+VPAH +R+ E +D+ ++E+ +I+ E Y G+ P V
Sbjct: 333 GAIMAVPAHD----------ERDYEFAKTFDLP---IKEVVSGGVIEQEAYTGDGPHVNS 379
Query: 379 VQKLGIKSQKDREK----LEQATKTIYKAEY--HKGIFKVPPYDGKPV 420
G+ ++ EK LE K K Y +F Y G+P+
Sbjct: 380 EFLNGLSKEEAIEKMIQWLEAEKKGTKKVTYRLRDWLFSRQRYWGEPI 427
Score = 91.3 bits (223), Expect = 5e-17
Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 20/246 (8%)
Query: 596 EEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIF------REEHWPKGIAVNGFGTLEGQ 649
E+ + W P+D G + HL + F H ++ +E + K +
Sbjct: 516 EKLKKWLPVDIYIGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLYNQGMILGENNE 575
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKSKGNV+N D I+ +GAD +RLY M + D+ W + RR L+R + L+
Sbjct: 576 KMSKSKGNVVNPDDIIDSHGADTLRLYEMFMGPLDASIAWSTTGLDGARRFLDRVWRLLV 635
Query: 710 QFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMR 769
E + L ++ ++ T+ EE R + +M + +
Sbjct: 636 DENTEEKSSKIVNGEGSPELKRAYHQTVKKVTEDFEELRFNVGIS----QLMVYVNEAYK 691
Query: 770 RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWN 829
+ E D+A+ F V+L++P PH+ EELW KLG EG ++ WP DE +
Sbjct: 692 QEELPLDQAEGF---------VKLLSPVAPHLAEELWSKLGHEGTIAYEPWP-TYDEAFL 741
Query: 830 EEVEVE 835
E EVE
Sbjct: 742 VEDEVE 747
>sp|P26499|SYI_METTM ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|68525|pir||SYEXI isoleucine--tRNA ligase (EC
6.1.1.5) [validated] - Methanobacterium
thermoautotrophicum (strain Marburg)
>gi|149728|gb|AAA72950.1| (M59245) transfer RNA-Ile
synthetase [Methanobacterium thermoautotrophicum]
Length = 1045
Score = 145 bits (363), Expect = 2e-33
Identities = 239/1017 (23%), Positives = 397/1017 (38%), Gaps = 210/1017 (20%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IEEK Q W E ++E + + + ++ PY SG +H+G A + D RFK
Sbjct: 15 IEEKVQSFWEERDIYERVKELREEGPRYSFLDGPPYCSGRIHLGTAWNKIMKDSYLRFKS 74
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M+G+NV GW G PI E I + +D+ ED + I ++
Sbjct: 75 MRGFNVRRQPGWDTHGLPIEHKVEGILG-----VRSKKDI-----------EDKIGIEEF 118
Query: 129 FMKAAK----------ETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVK 178
K + F R G +DW + T P + + W + EK +++
Sbjct: 119 VRKCREFAMENKAVMTSQFQRLGVWMDWDDPYVTFD--PAYMESCWWTLKRAHEKDLLLR 176
Query: 179 GAHRVRWDPVVGTPLG--DHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVY 236
+ W P T L + D E ED I +KF + GD Y+ T P T+
Sbjct: 177 DLRVITWCPRCETALALAEIDYHEKEDPSIY----VKFPVS-GDT--YILVWTTTPWTLP 229
Query: 237 GVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYV 296
+ ++P+ Y ++ ET+I+++ K+ + E E+I+ +G +L G
Sbjct: 230 ANMAVAVHPDFDYAHTRLDG----ETYIMAEALVEKVLGE--EAEIIKTVRGSELEGLTY 283
Query: 297 RNPVTGD-------EVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKY 349
R+P+ + E ++ + V TG V + P H P ED + E
Sbjct: 284 RHPLDEEVPCHRDMEHRVILGDHVTLTEGTGCVHTAPGHGP------EDFEIGKE----- 332
Query: 350 DIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGI 409
YG P V + G+ ++ A ++G+
Sbjct: 333 --------------------YG-LPVFCPVDEAGVFTED--------------AGKYRGL 357
Query: 410 FKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFG-----NRAVIKIIHDQ 464
F V++ I ++ K + + + R+G +I + +Q
Sbjct: 358 F---------VKDADSDIIDDLRSKNLL-----LRAETISHRYGFCWRCKTPIIYLATEQ 403
Query: 465 WFIDYGNSEWKEKARKALARMKIYP----ETR-RAQFEAIIDWLDKKACARKVGLGTPLP 519
WF+ +E K+K L R++ P E+R R E DW +R+ G P+P
Sbjct: 404 WFLKI--TEIKDKMLSELDRVQWIPSWAGESRFRNWIENARDW----TISRQRYWGIPIP 457
Query: 520 WDPEWVIESLSDSTIYMAYYTISRHINRLRE---EGRLDPEKLTPEFFDYIFLE----EF 572
WV E + + I LRE EG+L+ + + D I LE
Sbjct: 458 I---WVCEDCDSIHVVGS-------IGELRELAVEGQLEGDFIHRPHVDRIILECGRCGG 507
Query: 573 SEEREKEL------EKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHV 626
+R ++ G A KE F W+P D+ G D + V
Sbjct: 508 RMKRTPDVLDVWIDSGVAGWAALHYPREKELFSEWFPYDFITEGHDQTRGWFYSQLGCGV 567
Query: 627 AIFREEHWPKGIAVNGFGTL--EGQKMSKSKGNVLNFIDAIEENGADVVRLYIM--SLAE 682
E + + + ++GF TL EG+KMSKS GNV+ D IE+ GADV+R Y++ +
Sbjct: 568 IALDETPYRR-VLMHGF-TLDEEGRKMSKSLGNVVEPEDVIEKYGADVLRFYLLWANKPW 625
Query: 683 HDSDFDW-RRKEVGKLRRQLERFYELISQFAEYE-------AKENVELKTIDKWLLHRLN 734
D F W K V K+ L Y + + + E++ + D+W++ R+N
Sbjct: 626 EDLKFVWDELKNVNKMFNILWNVYVFATTYMSLDRFQPGDHELEDLHFRDEDRWIISRVN 685
Query: 735 KAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RWYMRRTEG-----RDDEAKRFVLRKLAD 788
T+AL+ A + I+ DL RWY+R RDD K L
Sbjct: 686 SVALKVTEALDNLHFHRATREIHDFIVEDLSRWYIRLIRSRTWIERDDPDKLAAYHSLYT 745
Query: 789 IWVRL---MAPFTPHICEELWEKL--GGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLI 843
L ++P PH+CE++++ L G E P+ + + V ED + +
Sbjct: 746 ALKTLIVTLSPIAPHVCEDIYQNLVRGAE--------PDSPESIHMLDWMVSEDAVDGKL 797
Query: 844 EDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHGKEV 903
E +I+ IE+ RA + +W V E+V + +D+++ E
Sbjct: 798 EAEMDIVREI-IEACARARDTARYKLRWPVREIVV-----------VSEDDKV----LEA 841
Query: 904 AKLVQAIIKERAFDVKRIDEEKVLRESKDFLEKELGLEVIINPE-EDKGGKKRQAIP 959
A+ ++ +I E+A K +R S +F + + +I P G K RQ +P
Sbjct: 842 AESLKGVIAEQA-------NAKSIRTSTEFPD----MRIIAKPNPATLGPKLRQDMP 887
>sp|Q9WY15|SYL_THEMA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437543|pir||F72408 leucine--tRNA ligase (EC
6.1.1.4) - Thermotoga maritima (strain MSB8)
>gi|4980663|gb|AAD35261.1|AE001702_1 (AE001702)
leucyl-tRNA synthetase [Thermotoga maritima]
Length = 824
Score = 144 bits (359), Expect = 5e-33
Identities = 144/500 (28%), Positives = 214/500 (42%), Gaps = 123/500 (24%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVF-EPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTI 59
M E + IE+KWQ+ W E KVF P +KPK +Y V FPY SG LHVGH + Y I
Sbjct: 1 MKEYRPQEIEKKWQEVWEEKKVFYTPQRSEKPK---YYALVMFPYPSGTLHVGHVKNYVI 57
Query: 60 PDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTF 119
D++AR+KRM+GYNVL P G+ G P A I + ++ PEE WT
Sbjct: 58 GDIVARYKRMRGYNVLHPFGYDAFGLPAENAA------------IEKGIH--PEE--WTR 101
Query: 120 EDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKG 179
++ I ++ + G S DWSRE T + K+ +W FL+L + G K
Sbjct: 102 KNIATI--------RQQVKKLGISYDWSREIATCD--EEYYKWTQWIFLQLYKNGLAYKK 151
Query: 180 AHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIK------FELKEGDETIY--LPAATLR 231
V W P T L + + +G+ V I+ F++ + E + L T
Sbjct: 152 KAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGW 211
Query: 232 PE-------------------------------------TVYGVTNMWINPNATYVKAKV 254
PE T++GVT M + P + V+ V
Sbjct: 212 PEHVKTMQRNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMALAPESPLVEELV 271
Query: 255 KRGGKEETWIISKEAAYKLSFQDR-EIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFV 313
KEE +E ++ QDR +E K +G+Y NPVTG+ + I A ++
Sbjct: 272 PEEKKEEL----QEFLERVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIYVANYI 327
Query: 314 DPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEF 373
+ TG +M VPAH +R+ KY I ++V +
Sbjct: 328 LMEYGTGAIMGVPAHD----------QRDFSFAKKYGIPIKVVIK--------------- 362
Query: 374 PAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIF-KVPPYDGKPVQEVKELIAKEMM 432
PA +++ D EK+E+A Y+ E GI P+DG P E E + +
Sbjct: 363 PADKDL---------DPEKMEEA----YEGE---GIMVNSGPFDGTPSSEGIEKVINWLE 406
Query: 433 EKGIAEIMYEFAEKN-VISR 451
EKGI + ++ ++ +ISR
Sbjct: 407 EKGIGKRSVQYKLRDWLISR 426
Score = 99.5 bits (244), Expect = 2e-19
Identities = 70/251 (27%), Positives = 122/251 (47%), Gaps = 17/251 (6%)
Query: 596 EEFEYWYPLDWRCSGKDLIPNHLTFFIF-----NHVAIFREEHWPKGIAVNGFGTLEGQK 650
++ YW P+D G + HL + F + + + + G +G K
Sbjct: 521 DDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFDEPFTNLFTQGMIYKDGAK 580
Query: 651 MSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE---L 707
MSKSKGNV++ + IE+ GAD +R+YI+ +A + D +W + + R ++R +
Sbjct: 581 MSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFVKRLWNTFYT 640
Query: 708 ISQFAEYEAKENVELK-TIDKWLLHRLNKAIEGTTKALE-EFRTRTAVQWAFYSIMNDLR 765
+ F + E EN+ LK + +K L +L+ I+ T+ +E F+ TA+ ++N L
Sbjct: 641 VLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAIS-GLMELVNHLS 699
Query: 766 WYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVD 825
Y+ +E R +LR++ + ++PF PH+ EE W LG + V WP
Sbjct: 700 QYLNSVP--QEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQSWP---- 753
Query: 826 EWWNEEVEVEE 836
+ + +EVEE
Sbjct: 754 SYDPKALEVEE 764
>dbj|BAB06264.1| (AP001515) isoleucyl-tRNA synthetase [Bacillus halodurans]
Length = 921
Score = 143 bits (357), Expect = 9e-33
Identities = 194/880 (22%), Positives = 354/880 (40%), Gaps = 138/880 (15%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
E + Q+ W + ++E F + PY +G +H+GHA + D+I R+K M
Sbjct: 24 EPQMQEEWKDMNIYEKVQARTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDMIVRYKSM 83
Query: 70 QGYNVLFPMGWHITGSPIV-GIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
G++ + GW G PI + + +R ++ +R K+ EE +
Sbjct: 84 AGFHAPYVPGWDTHGLPIEQALTKSGVDRKSMSVAEFR---KLCEEF----------ARK 130
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLK----LKEKGYIVKGAHRVR 184
+ +E F+R G DW + T K E Q +K + +KGYI KG V
Sbjct: 131 QIDRQREQFMRLGVRGDWWNPYVT------LDKGFEAQQVKVFGEMAKKGYIYKGKKPVY 184
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEG------DETIYLPAATLRPETVYGV 238
W P + L + ++ + YV F +K+G DE I + T P T+
Sbjct: 185 WSPSSESALAEAEIEYHDKRSPSIYVA--FPVKDGKNVLQQDEKIVIWTTT--PWTIPAN 240
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKL--SFQDREIEVIEEFKGEKLIGKYV 296
+ ++P Y VK E ++++ L + + E++ KG L
Sbjct: 241 LGIAVHPELEYSVVAVKG----EKYVVASGLVETLESALEWENPEILRTIKGVDLEYVVA 296
Query: 297 RNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIV 356
+P+ G + +++ + V D TG V + P H D++ + KY +D
Sbjct: 297 EHPIYGRDSLVVLGDHVTLDAGTGCVHTAPGHGEEDYIVGQ----------KYGLDV--- 343
Query: 357 EEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYD 416
L ++ G A + P ++
Sbjct: 344 -------LCPVDDKGYMTA-----------------------------------EAPGFE 361
Query: 417 GKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKE 476
G E + I +++ E G + + VI QWF N +++
Sbjct: 362 GLFYDEANKPITQKLDECGALLKLTFITHSYAHDWRTKKPVIYRATAQWFASIEN--FRD 419
Query: 477 KARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP-WDPEWVIESLSDSTIY 535
+ +A+ +K PE + ++ +R+ G P+P + E ++D TI
Sbjct: 420 ELLRAIQEVKWVPEWGETRLYNMVRDRGDWCISRQRVWGVPIPIFYGENGEPIITDETIN 479
Query: 536 MAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEK---KTGIPAEIIH 592
+H + + E + + L PE F + RE ++ +G + +
Sbjct: 480 HVSELFRKHGSNVWFEW--ETKDLLPEGFTHESSPNGQFTREMDIMDVWFDSGSSHQGVL 537
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTL--EGQK 650
+EE + P D G D + VAI + + KG+ +GF TL EG+K
Sbjct: 538 VEREELDR--PADLYLEGSDQYRGWFNSSLSTSVAITGKAPY-KGVLSHGF-TLDGEGKK 593
Query: 651 MSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDF---DWRRKEVGKLRRQLERFYE- 706
MSKS GNV+ D +++ GAD++RL++ S+ ++ +D D K+V ++ R++ Y
Sbjct: 594 MSKSLGNVVIPNDVMKQLGADILRLWVASV-DYQADVRVSDKILKQVSEVYRKIRNTYRF 652
Query: 707 LISQFAEYE-AKENV---ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQW------- 755
L+ ++ A V +L +D+++L +LN I KA +E++ T
Sbjct: 653 LLGNLHDFHPATHRVAIDQLNGLDRYMLAKLNDVINRVKKAYDEYQFSTVYHELHNFCTI 712
Query: 756 ---AFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGG- 811
+FY + Y++ + D A + V+ + +L++P PH +E+W+ + G
Sbjct: 713 ELSSFYMDIAKDTLYVKHADHPDRRATQTVMYDVLVALAKLLSPIIPHTADEVWKHIPGV 772
Query: 812 -EGFVSLAKWPEPVD--------EWWNEEVEVEEDFIKSL 842
E V L PEP++ + W+ + V +D +K+L
Sbjct: 773 EEESVQLTDMPEPIELGDVSELKQKWDAFINVRDDVLKAL 812
>sp|P73274|SYL_SYNY3 LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437530|pir||S77455 leucine--tRNA ligase (EC
6.1.1.4) - Synechocystis sp. (strain PCC 6803)
>gi|1652380|dbj|BAA17302.1| (D90905) leucyl-tRNA
synthetase [Synechocystis sp.]
Length = 869
Score = 140 bits (350), Expect = 6e-32
Identities = 112/396 (28%), Positives = 172/396 (43%), Gaps = 91/396 (22%)
Query: 5 NFRAIEEKWQKRWLEAKVFE-PNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
N IE+KWQ+RW E + + P D PK FY FPY SG+LH+GH R YTI DVI
Sbjct: 6 NAGEIEQKWQQRWAEWGLDKTPIASDLPK---FYALSMFPYPSGNLHMGHVRNYTITDVI 62
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
AR KRMQGY VL PMGW G P A I+ P W +++ ++ ++
Sbjct: 63 ARLKRMQGYQVLHPMGWDAFGLPAENAA--IERGIPPKQWTEKNIAQMRAQLQ------- 113
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
+ G S+DW RE T + P + ++ +W FL+ + G + V
Sbjct: 114 ---------------QLGLSIDWEREVATCA--PDYYRWTQWLFLEFFQAGLAYQKEATV 156
Query: 184 RWDPVVGTPLGDHDL-MEGED----------------VPILEY----------------- 209
WDP+ T L + + EG + I +Y
Sbjct: 157 NWDPIDQTVLANEQVDSEGRSWRSGAMVERKLLRQWFLKITDYAEALLNDLEQLTGWPER 216
Query: 210 --------------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPN--ATYVKAK 253
++F +K+ E I T RP+TVYGVT + + P T V
Sbjct: 217 VKLMQSHWIGKSVGAYLEFPIKDSQEKI--AVFTTRPDTVYGVTYVVLAPEHPLTKVVTT 274
Query: 254 VKRGGKEETWI--ISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAE 311
++ G + ++ ++KE+ + + +D+ ++ G NP G+E+ IL A+
Sbjct: 275 AEQQGTVDEFVAMVAKESEIERTAEDKPKRGVK-------TGGIAINPFNGEEIPILIAD 327
Query: 312 FVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILV 347
+V + TG VM VPAH D +D ++++
Sbjct: 328 YVLYEYGTGAVMGVPAHDQRDFKFAQDNNLPMQVVI 363
>gb|AAD36946.1|AF069441_6 (AF069441) putative leucyl tRNA synthetase [Arabidopsis thaliana]
>gi|7267192|emb|CAB77903.1| (AL161500) putative leucyl
tRNA synthetase [Arabidopsis thaliana]
Length = 973
Score = 140 bits (350), Expect = 6e-32
Identities = 113/398 (28%), Positives = 164/398 (40%), Gaps = 93/398 (23%)
Query: 6 FRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIA 64
F IE KWQ+ W + ++F + KFY+ FPY SG LHVGH YT D++A
Sbjct: 87 FHEIEPKWQRYWEDNRIFRTPDDVDTSKPKFYVLDMFPYPSGAGLHVGHPLGYTATDILA 146
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
R +RMQGYNVL PMGW G P A T D +++ + L
Sbjct: 147 RLRRMQGYNVLHPMGWDAFGLPAEQYAIETGTHPKTTTLKNIDRFRLQLKSL-------- 198
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
GFS DW RE TT P + K+ +W FL+L +KG + V
Sbjct: 199 ----------------GFSYDWDRELSTTE--PDYYKWTQWIFLQLYKKGLAYQAEVPVN 240
Query: 185 WDPVVGTPLGDHDLMEG-----------------------------EDVPILE------- 208
W P +GT L + ++++G ED+ LE
Sbjct: 241 WCPALGTVLANEEVVDGVSERGGHPVIRKPMRQWMLKITAYADRLLEDLDELEWPESIKE 300
Query: 209 ---------------YVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAK 253
+ I+ E +E D+ I T RP+T++G T M + P +
Sbjct: 301 MQRNWIGRSEGAELNFSILDGEGRETDKEI--TVYTTRPDTLFGATYMVVAPEHQLLSYF 358
Query: 254 VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFV 313
V K++ A+ K D E +++ K G Y +NP GD + I A++V
Sbjct: 359 VTAEQKQQVEEYKDFASRK---SDLERTELQKDKTGVFTGCYAKNPANGDAIPIWVADYV 415
Query: 314 DPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDI 351
TG +M+VPAH R++E +KY+I
Sbjct: 416 LASYGTGAIMAVPAHD----------TRDNEFALKYNI 443
>pir||F81974 leucine--tRNA ligase (EC 6.1.1.4) NMA0559 [similarity] - Neisseria
meningitidis (group A strain Z2491)
>gi|7379297|emb|CAB83851.1| (AL162753) putative
leucyl-tRNA synthetase [Neisseria meningitidis Z2491]
Length = 910
Score = 139 bits (348), Expect = 1e-31
Identities = 112/411 (27%), Positives = 178/411 (43%), Gaps = 97/411 (23%)
Query: 8 AIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
AIE QK+W +A++F N+ + + K+Y FPY SG LH+GH R YTI DV++RFK
Sbjct: 9 AIEPAAQKKWDDARIF--NVSEDASKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRFK 66
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
+ G+NV+ PMGW G P A +KN W Y D + +K
Sbjct: 67 LLNGFNVMQPMGWDAFGMPAENAA--MKNNVAPAAWTY---------------DNIEYMK 109
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+K+ GF++DW+RE T + P + ++ +W F KL EKG + + V WDP
Sbjct: 110 TQLKS-------LGFAIDWARE--TATCKPEYYRWEQWLFTKLFEKGIVYRKNGTVNWDP 160
Query: 188 VVGTPLGDHDLMEG-----------EDVPILEYVI------------------------- 211
V T L + +++G ++P+ + I
Sbjct: 161 VDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITDYAEELLNDLDKLEHWPEQVKTMQ 220
Query: 212 -----------IKFELK-------EGDETIYLPAATLRPETVYGVTNMWINPNATYVKAK 253
++F + EGD +L T RP+T+ G T + + A
Sbjct: 221 RNWIGKSRGMTVRFAVSDDSKQGLEGDYAKFLQVYTTRPDTLMGATYVAVAAEHPLATAA 280
Query: 254 VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFV 313
+ + +I +A S + ++ +E+ KG G+YV NP+ GD++ + A +V
Sbjct: 281 AADKPELQAFIAECKAG---SVAEADMATMEK-KGVP-TGRYVVNPLNGDKLEVWIANYV 335
Query: 314 DPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISL 364
G VM+VPAH +R+ E KY + + V + I L
Sbjct: 336 LWGYGDGAVMAVPAHD----------ERDFEFAAKYSLPKKQVLQRVTIGL 376
Score = 74.1 bits (179), Expect = 7e-12
Identities = 58/193 (30%), Positives = 88/193 (45%), Gaps = 13/193 (6%)
Query: 649 QKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELI 708
+KMSKSK N ++ + I GAD RL++M A + +W V R L R + +
Sbjct: 667 EKMSKSKNNGVDPQELINAYGADTARLFMMFAAPPEQSLEWSDSGVEGAHRFLRRLWRTV 726
Query: 709 SQFAEYEAKENVELKTID------KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMN 762
++ + N + D K L H+L+ I K +++ R A ++M
Sbjct: 727 YEYLKQGEAVNAFAGSQDGLSKELKDLRHKLHSTI---AKVSDDYGRRQQFNTAIAAVME 783
Query: 763 DLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPE 822
L Y + G E R V +++ + VRL+ P PHICE LW +L G A WP
Sbjct: 784 LLNQYDKTDTG--SEQGRTVAQEVLEAAVRLLWPIVPHICETLWSELNGAKLWE-AGWP- 839
Query: 823 PVDEWWNEEVEVE 835
VDE + E+E
Sbjct: 840 AVDEAALVKSEIE 852
>pir||G81029 leucine--tRNA ligase (EC 6.1.1.4) NMB1897 [similarity] - Neisseria
meningitidis (group B strain MD58)
>gi|7227154|gb|AAF42228.1| (AE002539) leucyl-tRNA
synthetase [Neisseria meningitidis MC58]
Length = 876
Score = 139 bits (347), Expect = 1e-31
Identities = 110/403 (27%), Positives = 176/403 (43%), Gaps = 97/403 (24%)
Query: 8 AIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
AIE QK+W +A++F N+ + + K+Y FPY SG LH+GH R YTI DV++RFK
Sbjct: 9 AIEPAAQKKWDDARIF--NVSEDASKPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRFK 66
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
+ G+NV+ PMGW G P A +KN W Y D + +K
Sbjct: 67 LLNGFNVMQPMGWDAFGMPAENAA--MKNNVAPAAWTY---------------DNIEYMK 109
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+K+ GF++DW+RE T + P + ++ +W F KL EKG + + V WDP
Sbjct: 110 TQLKS-------LGFAIDWARE--TATCKPEYYRWEQWLFTKLFEKGIVYRKNGTVNWDP 160
Query: 188 VVGTPLGDHDLMEG-----------EDVPILEYVI------------------------- 211
V T L + +++G ++P+ + I
Sbjct: 161 VDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITDYAEELLNDLDKLEHWPEQVKTMQ 220
Query: 212 -----------IKFELK-------EGDETIYLPAATLRPETVYGVTNMWINPNATYVKAK 253
++F + EGD +L T RP+T+ G T + + A
Sbjct: 221 RNWIGKSRGMTVRFAVSDDSKQGLEGDYAKFLQVYTTRPDTLMGATYVAVAAEHPLAAAA 280
Query: 254 VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFV 313
+ + +I +A S + ++ +E+ KG G+YV NP+ GD++ + A +V
Sbjct: 281 AADKPELQAFIAECKAG---SVAEADMATMEK-KGVP-TGRYVVNPLNGDKLEVWIANYV 335
Query: 314 DPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIV 356
G VM+VPAH +R+ E KY++ + V
Sbjct: 336 LWGYGDGAVMAVPAHD----------ERDFEFATKYNLPKKQV 368
Score = 72.6 bits (175), Expect = 2e-11
Identities = 61/197 (30%), Positives = 89/197 (44%), Gaps = 21/197 (10%)
Query: 649 QKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFY--- 705
+KMSKSK N ++ + I GAD RL++M A + +W V R L R +
Sbjct: 633 EKMSKSKNNGVDPQELINAYGADTARLFMMFAAPPEQSLEWSDSGVEGAHRFLRRLWRTV 692
Query: 706 -------ELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFY 758
E + FA + + ELK L H+L+ T K +++ R A
Sbjct: 693 YEYLKQGEAVKAFAGSQDGLSKELKD----LRHKLHAT---TAKVSDDYGRRQQFNTAIA 745
Query: 759 SIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLA 818
++M L Y + G E R V +++ + VRL+ P PHICE LW +L G A
Sbjct: 746 AVMELLNQYDKTDTG--GEQGRAVAQEVLETAVRLLWPIVPHICETLWSELNGAKLWE-A 802
Query: 819 KWPEPVDEWWNEEVEVE 835
WP VDE + E+E
Sbjct: 803 GWP-TVDEAALVKSEIE 818
>gi|11429025 isoleucine-tRNA synthetase [Homo sapiens]
>gi|730870|sp|P41252|SYI_HUMAN ISOLEUCYL-TRNA
SYNTHETASE, CYTOPLASMIC (ISOLEUCINE--TRNA LIGASE)
(ILERS) (IRS) >gi|2135522|pir||I59314 isoleucine--tRNA
ligase (EC 6.1.1.5) - human >gi|551622|dbj|BAA05835.1|
(D28473) isoleucyl-tRNA synthetase [Homo sapiens]
Length = 1266
Score = 139 bits (346), Expect = 2e-31
Identities = 212/871 (24%), Positives = 344/871 (39%), Gaps = 153/871 (17%)
Query: 1 MPE-LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTI 59
+PE +NF A EEK + W E F+ +K + KF P+ +G H GH TI
Sbjct: 9 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTI 68
Query: 60 PDVIARFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWT 118
D++ R+ G++V GW G P+ I + + R P DV K+ +
Sbjct: 69 KDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGP------EDVAKMG---ITE 119
Query: 119 FEDPVN-IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
+ + IV + K T R G +D+ ++ T L+P F + + W F +L +KG +
Sbjct: 120 YNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKT--LYPQFMESVWWVFKQLYDKGLVY 177
Query: 178 KGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYG 237
+G + + TPL + + + V + F L+E DET+ L A T P T+
Sbjct: 178 RGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEE-DETVSLVAWTTTPWTLPS 236
Query: 238 VTNMWINPNATYVKAK-VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGK-- 294
+ +NP YVK K V RG A YKL + + E++E F G L GK
Sbjct: 237 NLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKL---ESDYEILERFPGAYLKGKKY 293
Query: 295 -----YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALED---LKRESEIL 346
Y +L +V + TGVV P D+ D ++++S +
Sbjct: 294 RPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPV 353
Query: 347 VKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEY- 405
D E+T + G++ V++ K I++ K++ +L AT + +
Sbjct: 354 CPVDASGCFTTEVTDFA-------GQY--VKDADKSIIRTLKEQGRLLVATTFTHSYPFC 404
Query: 406 ----HKGIFK-VPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKI 460
I+K VP + + V +L+ + + E++ E RFGN
Sbjct: 405 WRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVRE-------KRFGN------ 451
Query: 461 IHDQWFIDYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP- 519
W + AR DW +R GTP+P
Sbjct: 452 -------------WLKDAR---------------------DW----TISRNRYWGTPIPL 473
Query: 520 W---DPEWVI--------ESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIF 568
W D E V+ E LS + I + H+ G+ +++ E FD F
Sbjct: 474 WVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRIS-EVFDCWF 532
Query: 569 LEEFSEEREKELEKKTGIPAEIIH---EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNH 625
+ +P +H E K EFE +P D+ G D +
Sbjct: 533 -------------ESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLA 579
Query: 626 VAIFREEHWPKGIAVNGFG-TLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHD 684
A+F + + K + VNG +GQKMSK K N + + I++ GAD +RLY+++
Sbjct: 580 TALFGQPPF-KNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVR 638
Query: 685 SDFDWRRKEVG---KLRRQLERFYE----LISQFAEYEAKENVEL-----------KTID 726
++ + R KE G L+ L +Y LI + +E +E D
Sbjct: 639 AE-NLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITD 697
Query: 727 KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYM----RRTEGRDD-EAKRF 781
+W+L + I + +R T V + WY+ RR +G + E
Sbjct: 698 RWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVM 757
Query: 782 VLRKLADIWV---RLMAPFTPHICEELWEKL 809
L L + + RLMAP+TP + E +++ L
Sbjct: 758 ALETLFSVLLSLCRLMAPYTPFLTELMYQNL 788
>gi|11429023 isoleucine-tRNA synthetase [Homo sapiens]
Length = 1262
Score = 139 bits (346), Expect = 2e-31
Identities = 212/871 (24%), Positives = 344/871 (39%), Gaps = 153/871 (17%)
Query: 1 MPE-LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTI 59
+PE +NF A EEK + W E F+ +K + KF P+ +G H GH TI
Sbjct: 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTI 64
Query: 60 PDVIARFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWT 118
D++ R+ G++V GW G P+ I + + R P DV K+ +
Sbjct: 65 KDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGP------EDVAKMG---ITE 115
Query: 119 FEDPVN-IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
+ + IV + K T R G +D+ ++ T L+P F + + W F +L +KG +
Sbjct: 116 YNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKT--LYPQFMESVWWVFKQLYDKGLVY 173
Query: 178 KGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYG 237
+G + + TPL + + + V + F L+E DET+ L A T P T+
Sbjct: 174 RGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEE-DETVSLVAWTTTPWTLPS 232
Query: 238 VTNMWINPNATYVKAK-VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGK-- 294
+ +NP YVK K V RG A YKL + + E++E F G L GK
Sbjct: 233 NLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKL---ESDYEILERFPGAYLKGKKY 289
Query: 295 -----YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALED---LKRESEIL 346
Y +L +V + TGVV P D+ D ++++S +
Sbjct: 290 RPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPV 349
Query: 347 VKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEY- 405
D E+T + G++ V++ K I++ K++ +L AT + +
Sbjct: 350 CPVDASGCFTTEVTDFA-------GQY--VKDADKSIIRTLKEQGRLLVATTFTHSYPFC 400
Query: 406 ----HKGIFK-VPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKI 460
I+K VP + + V +L+ + + E++ E RFGN
Sbjct: 401 WRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVRE-------KRFGN------ 447
Query: 461 IHDQWFIDYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP- 519
W + AR DW +R GTP+P
Sbjct: 448 -------------WLKDAR---------------------DW----TISRNRYWGTPIPL 469
Query: 520 W---DPEWVI--------ESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIF 568
W D E V+ E LS + I + H+ G+ +++ E FD F
Sbjct: 470 WVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRIS-EVFDCWF 528
Query: 569 LEEFSEEREKELEKKTGIPAEIIH---EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNH 625
+ +P +H E K EFE +P D+ G D +
Sbjct: 529 -------------ESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLA 575
Query: 626 VAIFREEHWPKGIAVNGFG-TLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHD 684
A+F + + K + VNG +GQKMSK K N + + I++ GAD +RLY+++
Sbjct: 576 TALFGQPPF-KNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVR 634
Query: 685 SDFDWRRKEVG---KLRRQLERFYE----LISQFAEYEAKENVEL-----------KTID 726
++ + R KE G L+ L +Y LI + +E +E D
Sbjct: 635 AE-NLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITD 693
Query: 727 KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYM----RRTEGRDD-EAKRF 781
+W+L + I + +R T V + WY+ RR +G + E
Sbjct: 694 RWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVM 753
Query: 782 VLRKLADIWV---RLMAPFTPHICEELWEKL 809
L L + + RLMAP+TP + E +++ L
Sbjct: 754 ALETLFSVLLSLCRLMAPYTPFLTELMYQNL 784
>gi|4504555 isoleucine-tRNA synthetase [Homo sapiens]
>gi|7770072|ref|NP_038203.1| isoleucine-tRNA synthetase
[Homo sapiens] >gi|440799|gb|AAA80153.1| (U04953)
isoleucyl-tRNA synthetase [Homo sapiens]
Length = 1262
Score = 137 bits (342), Expect = 5e-31
Identities = 211/871 (24%), Positives = 344/871 (39%), Gaps = 153/871 (17%)
Query: 1 MPE-LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTI 59
+PE +NF A EEK + W E F+ +K + KF P+ +G H GH TI
Sbjct: 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTI 64
Query: 60 PDVIARFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWT 118
D++ R+ G++V GW G P+ I + + R P DV K+ +
Sbjct: 65 KDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGP------EDVAKMG---ITE 115
Query: 119 FEDPVN-IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
+ + IV + K T R G +D+ ++ T L+P F + + W F +L +KG +
Sbjct: 116 YNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKT--LYPQFMESVWWVFKQLYDKGLVY 173
Query: 178 KGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYG 237
+G + + TPL + + + V + F L+E DET+ L A T P T+
Sbjct: 174 RGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEE-DETVSLVAWTTTPWTLPS 232
Query: 238 VTNMWINPNATYVKAK-VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGK-- 294
+ +NP YVK K V RG A YKL + + E++E F G L GK
Sbjct: 233 NLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKL---ESDYEILERFPGAYLKGKKY 289
Query: 295 -----YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALED---LKRESEIL 346
Y +L +V + TGVV P D+ D ++++S +
Sbjct: 290 RPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPV 349
Query: 347 VKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEY- 405
D E+T + G++ V++ K I++ K++ +L AT + +
Sbjct: 350 CPVDASGCFTTEVTDFA-------GQY--VKDADKSIIRTLKEQGRLLVATTFTHSYPFC 400
Query: 406 ----HKGIFK-VPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKI 460
I+K VP + + V +L+ + + E++ E RFGN
Sbjct: 401 WRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVRE-------KRFGN------ 447
Query: 461 IHDQWFIDYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP- 519
W + AR DW +R GTP+P
Sbjct: 448 -------------WLKDAR---------------------DW----TISRNRYWGTPIPL 469
Query: 520 W---DPEWVI--------ESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIF 568
W D E V+ E LS + I + H+ G+ +++ E FD F
Sbjct: 470 WVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRIS-EVFDCWF 528
Query: 569 LEEFSEEREKELEKKTGIPAEIIH---EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNH 625
+ +P +H E K EFE +P D+ G D +
Sbjct: 529 -------------ESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLA 575
Query: 626 VAIFREEHWPKGIAVNGFG-TLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHD 684
A+F + + K + VNG +GQKMSK K N + + I++ GAD +RLY+++
Sbjct: 576 TALFGQPPF-KNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVR 634
Query: 685 SDFDWRRKEVG---KLRRQLERFYE----LISQFAEYEAKENVEL-----------KTID 726
++ + R KE G L+ L +Y LI + +E +E D
Sbjct: 635 AE-NLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITD 693
Query: 727 KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYM----RRTEGRDD-EAKRF 781
+W+L + I + +R T V + WY+ RR +G + E
Sbjct: 694 RWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVM 753
Query: 782 VLRKLADIWV---RLMAPFTPHICEELWEKL 809
L L + + RL+AP+TP + E +++ L
Sbjct: 754 ALETLFSVLLSLCRLIAPYTPFLTELMYQNL 784
>sp|Q9YF67|SYI_AERPE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437559|pir||E72729 probable isoleucyl-tRNA
synthetase APE0374 - Aeropyrum pernix (strain K1)
>gi|5104013|dbj|BAA79329.1| (AP000059) 1064aa long
hypothetical isoleucyl-tRNA synthetase [Aeropyrum
pernix]
Length = 1064
Score = 137 bits (342), Expect = 5e-31
Identities = 228/1008 (22%), Positives = 390/1008 (38%), Gaps = 184/1008 (18%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIARFK 67
++ W++ + KV E K +KFY PY S +H+G A + DV+ RF
Sbjct: 22 VKSYWEENSIYRKVKE---KSSRAPRKFYFLDGPPYASAKSIHIGTAWNKVVKDVVLRFY 78
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
RM GYNV G+ G PI +K + + R++ EE + E+ + K
Sbjct: 79 RMTGYNVWDKPGYDTHGLPI-----EVKIEQSLGVRVKREI----EEKVGV-ENFIAACK 128
Query: 128 YF----MKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIE---WQFLKLKEKGYIVKGA 180
F M+A F G +DW + T ++IE W K EKG + KG
Sbjct: 129 RFVDENMEAMTRQFKEIGVFMDWENPYVTYR-----DEYIESGWWLVKKAWEKGLLYKGY 183
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
+ W P T L D+++ E ++ + +KF + EG E YL T P T+
Sbjct: 184 RVLHWCPRCETTLADYEVSEYRELED-PSIYVKFPV-EGREGEYLLVWTTTPWTLPANAF 241
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQD--REIEVIEEFKGEKLIGKYVRN 298
+ +P+ YVK +V R +T I++K + + E EV+E KG +L G R+
Sbjct: 242 VMAHPDMEYVKVRVGR----DTLILAKARLDHVMREAGVSEYEVLEVLKGSQLEGLRYRH 297
Query: 299 PVTGDEV-----------IILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILV 347
P+ D V +++ E V P +G+V S P H D
Sbjct: 298 PLE-DVVDAQRELSKWHKVVMAPEAVTPHEGSGLVHSAPGHGTID--------------- 341
Query: 348 KYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHK 407
Y+I RI + +SL+ G+ E A K Y Y +
Sbjct: 342 -YEIAQRIGAPV--VSLVDERGF---------------------MTEAAGK--YSGLYFR 375
Query: 408 GIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFI 467
G E + I +++ +G + + ++ QWF+
Sbjct: 376 G-------------EANKAIVEDLRARGALFHAATIVHRYPVCWRCKTPLLLRATTQWFV 422
Query: 468 DYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIE 527
+ K + + +++ P + +F ++ L +R+ G PL P W
Sbjct: 423 --AVTRLKNQLMREAEKVEWQPGWAKTRFMNMLRELRDWVISRQRYWGIPL---PVWRCS 477
Query: 528 SLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLE----EFSEEREKEL--- 580
S Y + + L G PE L + D + L+ S +R ++
Sbjct: 478 S-------CGYEHVVGSVEELESMGGRRPENLHRPWVDRVELKCPRCGGSMKRVPDVLDV 530
Query: 581 --------EKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREE 632
G P + +E +E P+D+ G D I + + V F E
Sbjct: 531 WFDSGIAFYASLGYPRD-----RETWERLKPVDFIVEGHDQIRGWFFSLLRSGVIGFGET 585
Query: 633 HWPKGIAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIM-SLAEHDSDFDWR 690
+ + + V+GF E G++M KS GN ++F + I + DVVR +++ + D F W
Sbjct: 586 PY-RRVLVHGFALDEQGREMHKSLGNYVDFEELIAKVPRDVVRFWVLQNTVWEDLRFSW- 643
Query: 691 RKEVGKLRRQLERFYELISQFAEYEAKENVE------------LKTIDKWLLHRLNKAIE 738
K + +RR + + + + Y + + L+ D+W+L RL
Sbjct: 644 -KGLDLMRRDFNVIWNVYAFASIYMGLDRFDPRRTSLSSVEDSLEVEDRWILSRLASLKR 702
Query: 739 GTTKALEEFRTRTAVQWAFYSIMNDL-RWYMRRTEGR-----DDEAKRFVLRKLADI--- 789
A+E+ R A + I+ D+ WY+R R D +KR L +
Sbjct: 703 RYLTAMEDLRIHDAARALRSFIIEDVSHWYLRIIRRRVWEEVDTPSKRAAYATLYKVLWE 762
Query: 790 WVRLMAPFTPHICEELWEKLGGEG------FVSLAKWPEPVDEWWNEEVEVEEDFIKSLI 843
W+ + AP P+ E L+ K+ E + + PEP D + +E + + + ++
Sbjct: 763 WLLMAAPLIPYTAEYLYIKVFREAEERPEESIHMLDMPEPEDHLIDSTLEEDMEKARMVL 822
Query: 844 EDIKEIIEVA--KIESPKRAYIYTAP----EWKWKVYE----VVAEKREFKSAMAELMKD 893
E I A K+ P R I A E + E ++A +E + A A ++
Sbjct: 823 EAILSARNEAGLKLRRPVRRVIIAASNPGVEGSLRRLEGLIRLMANAKEIEFAPASALEA 882
Query: 894 EEIRKHGKEVAKL----------VQAIIKERAFDVKRIDEEKVLRESK 931
I + + +L V +I+E+ ++ R+ EK + E +
Sbjct: 883 TRIYRVEPDYGRLGPKYKRDMPKVLRLIEEKGGEIGRVLAEKGVYEGE 930
>sp|P56690|SYI_THETH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|4930049|pdb|1ILE| Isoleucyl-Trna Synthetase
Length = 821
Score = 137 bits (341), Expect = 7e-31
Identities = 205/883 (23%), Positives = 348/883 (39%), Gaps = 164/883 (18%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
E NF +EE+ W K+F+ +++++ ++ + P +G HVGHA+ + D+
Sbjct: 7 EPNFPKLEEEVLAFWKREKIFQKSVENRKGGPRYTVYEGPPTANGLPHVGHAQARSYKDL 66
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWTF 119
R+K M+GY GW G P+ E+ +K++ + + E ++T+
Sbjct: 67 FPRYKTMRGYYAPRRAGWDTHGLPVELEVEKKLGLKSKREIEAYGIERFNQACRESVFTY 126
Query: 120 EDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKG 179
E K + R + VD + T L P + + I W L ++G + +
Sbjct: 127 E----------KEWEAFTERIAYWVDLEDAYAT--LEPTYIESIWWSLKNLFDRGLLYRD 174
Query: 180 AHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKE----GDETIYLPAATLRPETV 235
V + P GTPL H++ G V ++F LKE G E L T P T+
Sbjct: 175 HKVVPYCPRCGTPLSSHEVALGYKEIQDPSVYVRFPLKEPKKLGLEKASLLIWTTTPWTL 234
Query: 236 YGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKY 295
G ++P TY AA+++ E ++EE G KL+G+
Sbjct: 235 PGNVAAAVHPEYTY-------------------AAFQVG---DEALILEEGLGRKLLGE- 271
Query: 296 VRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRI 355
T V+ + P A LE L P+
Sbjct: 272 ----------------------GTQVLKTFPGKA------LEGLPYTPPY-------PQA 296
Query: 356 VEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPY 415
+E+ ++ L + + V + +D E + K +G V P+
Sbjct: 297 LEKGYFVVLADYVSQEDGTGI--VHQAPAFGAEDLETARVYGLPLLKTVDEEGKLLVEPF 354
Query: 416 DGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGN--RAVIKIIH---DQWFIDYG 470
G +E I +++ +G+ F E++ + + + R +++ + WFI
Sbjct: 355 KGLYFREANRAILRDLRGRGLL-----FKEESYLHSYPHCWRCSTPLMYYATESWFIK-- 407
Query: 471 NSEWKEKARKALARMKIYP----ETRRAQF-EAIIDWLDKKACARKVGLGTPLPWDPEWV 525
N+ +K++ + + P E R ++ + ++DW A +R GTPLP WV
Sbjct: 408 NTLFKDELIRNNQEIHWVPPHIKEGRYGEWLKNLVDW----ALSRNRYWGTPLPI---WV 460
Query: 526 IESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELE---- 581
++ ++ + + E DP + + D + L + +
Sbjct: 461 CQACGKEEAIGSFQELKARATKPLPEP-FDPHR---PYVDQVELACACGGTMRRVPYVID 516
Query: 582 ---KKTGIPAEIIH---EMKEEFEYWYPLDWRCSGKDLIP------NHLTFFIFNHVAIF 629
+P +H E +E F +P D+ G D + L +F +A
Sbjct: 517 VWYDSGAMPFASLHYPFEHEEVFRESFPADFIAEGIDQTRGWFNSLHQLGVMLFGSIAF- 575
Query: 630 REEHWPKGIAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFD 688
K + +G E GQKMSKSKGNV++ D I + GAD +R YI A ++D
Sbjct: 576 ------KNVICHGLILDEKGQKMSKSKGNVVDPWDIIRKFGADALRWYIYVSAPPEAD-- 627
Query: 689 WRRKEVGKLRRQLERFY-----ELISQFAEYEAKENVELKT---------IDKWLLHRLN 734
R+ L R+ R Y + S F Y + +LK +D+WLL R+
Sbjct: 628 --RRFGPNLVRETVRDYFLTLWNVYSFFVTYANLDRPDLKNPPPPEKRPEMDRWLLARMQ 685
Query: 735 KAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RWYMRRTEGR--------DDEAKRFVLRK 785
I+ T+ALE + T+ + ++ DL +WY+RR R D EA L +
Sbjct: 686 DLIQRVTEALEAYDPTTSARALRDFVVEDLSQWYVRRNRRRFWKNEDALDREAAYATLYE 745
Query: 786 LADIWVRLMAPFTPHICEELWE------KLGGEGFVSLAKWPE 822
+ L APFTP + E LW+ +L + V LA WPE
Sbjct: 746 ALVLVATLAAPFTPFLAEVLWQNLVRSVRLEAKESVHLADWPE 788
>sp|P43827|SYL_HAEIN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|1074962|pir||H64102 leucine--tRNA ligase (EC
6.1.1.4) - Haemophilus influenzae (strain Rd KW20)
>gi|1573943|gb|AAC22581.1| (U32774) leucyl-tRNA
synthetase (leuS) [Haemophilus influenzae Rd]
Length = 861
Score = 136 bits (339), Expect = 1e-30
Identities = 129/445 (28%), Positives = 188/445 (41%), Gaps = 97/445 (21%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE K Q+ W E KVF+ IKD+ KEK +Y FPY SG LH+GH R YTI DVI+R++R
Sbjct: 10 IEPKVQQYWAENKVFKA-IKDESKEK-YYCLSMFPYPSGRLHMGHVRNYTIGDVISRYQR 67
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M G NVL P GW G P G A IKN+ W Y ++
Sbjct: 68 MLGKNVLQPFGWDAFGLPAEGAA--IKNKTAPAKWTYENI-------------------A 106
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+MK + GF DW RE T P + K+ +W F +L +KG + K V W P
Sbjct: 107 YMKKQLQLL---GFGFDWDREIATCK--PEYYKWEQWFFTELYKKGLVYKKTSTVNWCPN 161
Query: 189 VGTPLGDHDLMEG----EDVPILEYVIIKFELK--------------------------- 217
T L + + EG D P+ + I ++ +K
Sbjct: 162 DETVLANEQVHEGCCWRCDTPVEQKEIPQWFIKITDYAEQLLGGLDTLPQWPDMVKTMQR 221
Query: 218 ------EGDETIY--------LPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEETW 263
EG E + + T RP+T YGV+ + I A + A + E
Sbjct: 222 NWIGRSEGVEITFDVANTNEKVAVYTTRPDTFYGVSYLGI--AAAHPLASLAAQNNSELA 279
Query: 264 IISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVM 323
+EA + + E ++ K G + +P+TGD++ I A FV TG VM
Sbjct: 280 AFIQEAK---NAKVAEADLATMEKKGMATGLFAIHPLTGDKLPIWVANFVLMHYGTGAVM 336
Query: 324 SVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEI-----TYISLIKLEGYGEFPA--- 375
+VPAH D + ++ + +K I P EEI ++ KL EF
Sbjct: 337 AVPAHDQRDF----EFAQKYSLPIKQVIAPLADEEIDLTKQAFVEHGKLVNSDEFDGKNF 392
Query: 376 -------VEEVQKLGIKSQKDREKL 393
++++KLG+ ++ +L
Sbjct: 393 DGAFNGIADKLEKLGVGKRQVNYRL 417
Score = 90.1 bits (220), Expect = 1e-16
Identities = 71/266 (26%), Positives = 123/266 (45%), Gaps = 27/266 (10%)
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKSK N ++ + +E+ GAD VRL++M + + +W+ V +R L R + L+
Sbjct: 619 KMSKSKNNGIDPQEMVEKYGADTVRLFMMFASPAEMTLEWQESGVEGAKRFLGRVWNLVY 678
Query: 710 QFAEYEAKENVELKTI---DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW 766
Q+ + AK +++L + K L ++K I + + +T A +MN L
Sbjct: 679 QYQQNPAKTSLDLTALSAEQKVLRREVHKTIAKVSDDIGRRQTFNTAIAAVMELMNKL-- 736
Query: 767 YMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDE 826
D E R V+ + VR++ P TPHIC ELW+ LG E + A+W
Sbjct: 737 ---TKASLDSEQDRAVMAEALSAVVRMLYPITPHICFELWQALGNESAIDTAEW------ 787
Query: 827 WWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSA 886
V+ +E +++ED K I V ++ R + A + + +A E
Sbjct: 788 -----VKADE---AAMVEDEKLI--VVQVNGKVRGKVTVATDADEDTVKTIAFADE---N 834
Query: 887 MAELMKDEEIRKHGKEVAKLVQAIIK 912
+ + + ++ I K V KL+ ++K
Sbjct: 835 VKKFIDNQHIVKVIYVVGKLLNVVVK 860
>pir||A41882 leucine--tRNA ligase (EC 6.1.1.4) - Bacillus subtilis
>gi|143148|gb|AAA22571.1| (M88581) transfer RNA-Leu
synthetase [Bacillus subtilis]
Length = 804
Score = 132 bits (328), Expect = 2e-29
Identities = 107/367 (29%), Positives = 151/367 (40%), Gaps = 76/367 (20%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIAR 65
+ IE+KWQ WLE K F D +++KFY FPY SG LHVGH YT D+++R
Sbjct: 6 KEIEKKWQTYWLENKTFAT--LDNNEKQKFYALDMFPYPSGAGLHVGHPEGYTATDILSR 63
Query: 66 FKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNI 125
KRMQGY+VL PMGW G P + L T DP
Sbjct: 64 MKRMQGYDVLHPMGWDAFGLP------------------------AEQYALDTGNDPAVF 99
Query: 126 VKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRW 185
K + + GFS DW RE TT P + K+ +W FLKL EKG V W
Sbjct: 100 TKQNIDNFRRQIQALGFSYDWDREINTTD--PEYYKWTQWIFLKLYEKGLAYVDEVPVNW 157
Query: 186 DPVVGTPLGDHDLMEGEDV----PILEYVIIKFELK---EGDETIYLPAATLRPETVYGV 238
P +GT L + ++++G+ P+ ++ ++ LK D + PE++ +
Sbjct: 158 CPALGTVLANEEVIDGKSERGGHPVERRLMKQWMLKINAYADRLLEDLEELDWPESIKDM 217
Query: 239 TNMWIN-------------------------------------PNATYVKAKVKRGGKEE 261
WI N + K ++ K+
Sbjct: 218 QRNWIGRSEGAHVHFAIDGHDDSFTVFTTDQIRCLALHTLSLPRNTHWWKTSQRQSKKKL 277
Query: 262 TWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGV 321
+I KE K D E + + K G Y NPV G+++ I A++V TG
Sbjct: 278 LKLIIKEIQSK---SDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA 334
Query: 322 VMSVPAH 328
VM+VP H
Sbjct: 335 VMAVPGH 341
Score = 83.5 bits (203), Expect = 1e-14
Identities = 64/239 (26%), Positives = 104/239 (42%), Gaps = 35/239 (14%)
Query: 596 EEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIF------REEHWPKGIAVNGFGTLEGQ 649
E+ E W P+D G + HL + F H ++ +E + K +
Sbjct: 516 EKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQGMILGENNE 575
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKSKGNV+N + + +GAD +RLY M + D+ W + RR L+R + L
Sbjct: 576 KMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGARRFLDRVWRL-- 633
Query: 710 QFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQ-------WAFYSIMN 762
F E + N K +EG + LE T ++ F + ++
Sbjct: 634 -FIEDSGELN--------------GKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGIS 678
Query: 763 DLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
L ++ + K ++ + +V+L++P PH+ EELWEKLG G ++ WP
Sbjct: 679 QLMVFINEAYKATELPKEYM-----EGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWP 732
>dbj|BAB17162.1| (AP002868) putative leucyl-tRNA synthetase [Oryza sativa]
Length = 946
Score = 131 bits (327), Expect = 3e-29
Identities = 109/378 (28%), Positives = 160/378 (41%), Gaps = 82/378 (21%)
Query: 9 IEEKWQKRWLEAKVFE-PNIKD--KPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIA 64
IE +WQ+ W E + F P+I + K YI FPY SG LHVGH YT D+++
Sbjct: 70 IEPRWQRHWEEHRTFRTPDIGHGLDTSKPKCYILDMFPYPSGAGLHVGHPLGYTATDILS 129
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
RFKRMQG+NVL PMGW G P A I+ I R++ + ++
Sbjct: 130 RFKRMQGFNVLHPMGWDAFGLPAEQYA--IETGTHPKITTERNINRFRSQL--------- 178
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
GFS DW RE TT P + K+ +W FL+L ++G + V
Sbjct: 179 -----------QLKSLGFSYDWDREISTTE--PTYYKWTQWIFLQLLKRGLAYQAEVPVN 225
Query: 185 WDPVVGTPLGDHDLMEG-----------------------------EDVPILEYVIIKFE 215
W P +GT L + ++++G ED+ L++ E
Sbjct: 226 WCPALGTVLANEEVIDGVSERGGHPVIRKPMRQWMLRITSYADRLLEDLDELDWPESIKE 285
Query: 216 L-------------------KEG-DETIYLPAATLRPETVYGVTNMWINPNATYVKAKVK 255
+ KEG D L T RP+T++G T + + P + + + +
Sbjct: 286 MQRNWIGRSEGAELEFSAVDKEGHDLGANLLVYTTRPDTIFGATYVVLAPEHSLLSSLIS 345
Query: 256 RGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDP 315
+ E +I +L D + E F G Y +NP TG+ V I A++V
Sbjct: 346 EEQRVEEYIELTARKSELERTDLQKEKTGVFS-----GSYAKNPATGEIVPIWVADYVLG 400
Query: 316 DNATGVVMSVPAHAPFDH 333
TG +M+VPAH DH
Sbjct: 401 SYGTGAIMAVPAHDSRDH 418
Score = 73.4 bits (177), Expect = 1e-11
Identities = 54/187 (28%), Positives = 87/187 (45%), Gaps = 21/187 (11%)
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKS+GNV+N D + E GAD +RLY M + W + + R L R + L+
Sbjct: 712 KMSKSRGNVINPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTGGIEGVHRFLGRTWRLVV 771
Query: 710 QFAEYEAKENV------ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
+ V E T+D+ L L+K I T+ ++E R TA+ +
Sbjct: 772 GTPLPDGSYGVGTTVTDEEPTLDQ--LRVLHKCIARVTEEIQETRFNTAISAMMEFVNAA 829
Query: 764 LRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEP 823
+W D + K + + ++ L++PF PH+ EELW +LG ++ ++PE
Sbjct: 830 YKW--------DTQPKSVI-----ESFILLLSPFAPHMAEELWFRLGNSRSLAHEQFPEG 876
Query: 824 VDEWWNE 830
E+ E
Sbjct: 877 KSEYLKE 883
>gb|AAG10490.1|AF279106_52 (AF279106) predicted leucyl-tRNA synthetase (leuS) [uncultured
proteobacterium EBAC31A08]
Length = 804
Score = 131 bits (326), Expect = 4e-29
Identities = 110/407 (27%), Positives = 176/407 (43%), Gaps = 103/407 (25%)
Query: 2 PELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
PE N IE+ Q WL+ F+ N + +KFY FPY SG LH+GH R YTI D
Sbjct: 3 PEYNPSQIEKTIQDEWLKEDKFKANPDGR---EKFYCLSMFPYPSGKLHMGHVRNYTIGD 59
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPI--VGIAERIKNRDPHTIWIYRDVYKVPEEILWTF 119
VI+R+KRM +NV PMGW G P IA ++ +D WT
Sbjct: 60 VISRYKRMNNFNVFQPMGWDAFGLPAENAAIANKVSPKD------------------WTN 101
Query: 120 EDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKG 179
++ ++ K+ I G DWS+E T P + K+ + F K +KG + +
Sbjct: 102 QN--------IEHMKQQLISLGLGYDWSKELRTCE--PEYYKWEQLIFKKFYDKGLVYRK 151
Query: 180 AHRVRWDPVVGTPLGDHDLMEGED----------------VPILEY-------------- 209
V WDPV T L + +++G+ + I +Y
Sbjct: 152 KSLVNWDPVDETVLANEQVIDGKGWRSGAQVEIKEIDQWFIKITDYAEELLTSLDEVDWP 211
Query: 210 ----------------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAK 253
IK+ +++ D++ L + RP+T++GV+ + I+PN + +
Sbjct: 212 ENVKTMQRNWIGKSQGAEIKYMIEDSDDS--LKVFSTRPDTIFGVSFLAISPNHS-ISIG 268
Query: 254 VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKL---IGKYVRNPVTGDEVIILPA 310
+ + + ++K K + D K EKL G +V +P+T ++ +
Sbjct: 269 LSKNNESIKDFLNKCKEVKAAEADMA-------KAEKLGINSGMHVIHPITKKKIPVWIG 321
Query: 311 EFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDID-PRIV 356
FV D TGVVM VPAH +R+ E KY+++ P+++
Sbjct: 322 NFVLLDYGTGVVMGVPAHD----------QRDFEFASKYNLEIPQVI 358
Score = 81.9 bits (199), Expect = 3e-14
Identities = 64/221 (28%), Positives = 101/221 (44%), Gaps = 23/221 (10%)
Query: 599 EYWYPLDWRCSGKDLIPNHLTFFIFNHVAI----FREEHWP-KGIAVNGFGTLEGQKMSK 653
+YW P+D G + HL + F H A+ E + P K + G +G KMSK
Sbjct: 506 KYWLPVDLYIGGIEHAILHLLYSRFFHKALRDMDLVEGNEPFKKLLTQGMVLKDGAKMSK 565
Query: 654 SKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS--QF 711
SKGN ++ IE+ GAD VRLY+M A + +W V R +++ + L+S +F
Sbjct: 566 SKGNTVDPQSYIEKYGADTVRLYMMFTAPPEQSLEWSESSVEGASRFMKKIWNLVSNRKF 625
Query: 712 AEYE-----AKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW 766
+ E +K+ VEL+ K+ K +F TR + A SIM + +
Sbjct: 626 IDLEEPKDPSKQEVELR----------RKSHNTLKKVTNDFETRYSFNTAIASIMELVNF 675
Query: 767 YMRR-TEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELW 806
EG + ++ L + I ++ + P PHI + LW
Sbjct: 676 IPDSFKEGNASISNQYCLNEAIIIILKTLNPIAPHISQHLW 716
>sp|Q9ZDB1|SYL_RICPR LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437545|pir||D71700 leucine--tRNA ligase (EC
6.1.1.4) (leuS) RP421 - Rickettsia prowazekii
>gi|3860978|emb|CAA14878.1| (AJ235271) LEUCYL-TRNA
SYNTHETASE (leuS) [Rickettsia prowazekii]
Length = 828
Score = 131 bits (325), Expect = 5e-29
Identities = 118/440 (26%), Positives = 184/440 (41%), Gaps = 95/440 (21%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE+KWQK W E K F+ + ++ + K+Y+ PY SG +H+GH R Y+I DVIARF
Sbjct: 4 IEKKWQKIWQEEKAFQ--VSNESSKPKYYVLEMLPYPSGKIHIGHVRNYSIGDVIARFMT 61
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
MQG+NVL PMGW G P A IKN W Y + ++Y
Sbjct: 62 MQGFNVLHPMGWDAFGLPAENAA--IKNNSRPQDWTYSN------------------IEY 101
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
K + GF+ DW+RE S P + K + FL+L ++ + + V WDPV
Sbjct: 102 MKKQLQS----MGFAYDWTREI--NSCDPEYYKHEQKFFLELYDRNLVYQKESLVNWDPV 155
Query: 189 VGTPLGDHDLMEGED----------------VPILEY----------------------- 209
T L + +++G + I +Y
Sbjct: 156 DNTVLANEQVVDGRGWRSGAIIEKRYLKQWFLKITDYAEELLNEIQNLKDWPAAVRVMQE 215
Query: 210 --------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEE 261
V F++K + T + + +PET++G + + I N ++ + + +
Sbjct: 216 EWIGKSTGVNFHFKVKYHENTT-IEVFSTKPETIFGASFIGIAFNHPIIEQLICKTPEIV 274
Query: 262 TWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILP---AEFVDPDNA 318
+I K S+ R E+ + K G YV +P D I LP FV D
Sbjct: 275 NFIT------KCSYITRSSEIDKAEKEGIFSGLYVIHPF--DANIFLPVIITNFVLMDYG 326
Query: 319 TGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEFPA--- 375
TG + PAH DH +L + + +K I+ ++E I+ L G A
Sbjct: 327 TGAIFGCPAHDKRDH----ELAIKMNLPIKQVIETGNIQEGILINSDWLNGLTSSEAKQK 382
Query: 376 -VEEVQKLGIKSQKDREKLE 394
+E+ +KLGI + +L+
Sbjct: 383 VIEKFEKLGIGKRSVNYRLK 402
>sp|O66680|SYLA_AQUAE LEUCYL-TRNA SYNTHETASE ALPHA SUBUNIT (LEUCINE--TRNA LIGASE ALPHA
SUBUNIT) (LEURS) >gi|7519891|pir||D70331 leucine--tRNA
ligase (EC 6.1.1.4) alpha chain - Aquifex aeolicus
>gi|2983033|gb|AAC06643.1| (AE000685) leucyl-tRNA
synthetase alpha subunit [Aquifex aeolicus]
Length = 634
Score = 129 bits (321), Expect = 2e-28
Identities = 78/202 (38%), Positives = 103/202 (50%), Gaps = 29/202 (14%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
M E N R IE+KWQKRW EA VF+ + K KFY+ FPY SG +H+GH R YTI
Sbjct: 2 MKEFNPREIEKKWQKRWEEAGVFKAQ---EGKPNKFYVLEMFPYPSGRIHMGHVRNYTIG 58
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
D IAR+ +M+G N+L PMGW G P A + H I WT+E
Sbjct: 59 DAIARYLKMRGKNILHPMGWDAFGLPAENAAIK------HGI----------HPAKWTYE 102
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
+ + Y K K GFS DW RE T P + K+ +W FLK+ E+G +
Sbjct: 103 N----IDYMKKQLK----ILGFSYDWDREIATCD--PEYYKWNQWIFLKMLERGIAYRKT 152
Query: 181 HRVRWDPVVGTPLGDHDLMEGE 202
+V W P T L + ++EG+
Sbjct: 153 AKVNWCPHDQTVLANEQVIEGK 174
>pir||D75307 leucyl-tRNA synthetase - Deinococcus radiodurans (strain R1)
>gi|6459971|gb|AAF11720.1|AE002050_6 (AE002050)
leucyl-tRNA synthetase [Deinococcus radiodurans]
Length = 874
Score = 128 bits (319), Expect = 3e-28
Identities = 102/372 (27%), Positives = 158/372 (42%), Gaps = 87/372 (23%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N AIE+KWQ +W E+ +++ + +KFY FPY SG+LH+GH PD A
Sbjct: 70 NPHAIEQKWQGQWQESGLYK--FDENAPGEKFYALTMFPYPSGNLHIGHWYANVAPDARA 127
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
R+ RM+GYNVLFPM + G P A IKN W Y ++ ++ +
Sbjct: 128 RWLRMRGYNVLFPMAFDAFGLPAENAA--IKNNTNPATWTYANIERMTGQ---------- 175
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
F R G +DWSR+F T P + ++ +W F++ ++G K V
Sbjct: 176 ------------FSRMGTMIDWSRKFATCD--PEYYRWNQWFFIEFWKRGLAYKKGGLVN 221
Query: 185 WDPVVGTPLGDHDLMEGE----------------DVPILEY------------------- 209
W P T L + ++ G + I +Y
Sbjct: 222 WCPKDQTVLANEQVVNGHCERCGTAVERRNLSQWYLKITDYAEELLDFSATDMPEKVRAM 281
Query: 210 ----------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGK 259
+ F+ G ET++ T RP+T+ G T M + P AKVK
Sbjct: 282 QTNWIGKSVGAEVTFDTPAGPETVF----TTRPDTLMGATFMVLAPE----HAKVKELTT 333
Query: 260 EETWIISKEAAYKLSFQDREIEVIEEFKGEK---LIGKYVRNPVTGDEVIILPAEFVDPD 316
+E E ++ R+ +V + +GEK G Y +P++G ++ I A++V
Sbjct: 334 DEQ---RAEVEAYVAAAGRKTDVERQQEGEKTGVFTGSYATHPISGHQLPIWVADYVLVT 390
Query: 317 NATGVVMSVPAH 328
TG +M+VPAH
Sbjct: 391 YGTGSIMAVPAH 402
Score = 71.0 bits (171), Expect = 6e-11
Identities = 50/180 (27%), Positives = 87/180 (47%), Gaps = 11/180 (6%)
Query: 647 EGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE 706
+G+KMSKS+GNV++ D + E GAD VR ++M +A + W + + + L R +
Sbjct: 638 DGEKMSKSRGNVVDPDDLVREYGADTVRAFLMFIAPWELGGPWDPQGINGPSKWLSRVWN 697
Query: 707 LISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW 766
+ F E + +++ D + A+ K + + R + ++M
Sbjct: 698 VF--FEEKVSGPEEKMQGAD------VRFAVHSALKKVNDDFERMSFNTIISTLMELTNA 749
Query: 767 YMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDE 826
++ R V + DI+ R++AP PHI EE+W + G +G V A+WP+ VDE
Sbjct: 750 LVKAK--RSPVFGTPVWEEALDIFNRMLAPVVPHIAEEIWHERGQKGSVHTAQWPQ-VDE 806
>pir||D72206 valine--tRNA ligase (EC 6.1.1.9) - Thermotoga maritima (strain
MSB8) >gi|4982399|gb|AAD36880.1|AE001819_3 (AE001819)
valyl-tRNA synthetase [Thermotoga maritima]
Length = 865
Score = 128 bits (319), Expect = 3e-28
Identities = 111/406 (27%), Positives = 183/406 (44%), Gaps = 71/406 (17%)
Query: 1 MPELNFR----AIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHART 56
M EL+ R IE KW + W E F P K +KF I + P ++G +H+GHA
Sbjct: 1 MAELSTRYNPAEIETKWYRYWEEKGYFTP----KGVGEKFSIVIPPPNITGRIHMGHALN 56
Query: 57 YTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIAER--IKNRDPHTIWIYRDVYKVPEE 114
T+ D++ R+KRM+GY+VL+ G G E+ ++ + I R+ + E
Sbjct: 57 ITLQDIVVRYKRMKGYDVLWVPGEDHAGIATQNAVEKFLLQTQGKTREEIGREKFL---E 113
Query: 115 ILWTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKG 174
I W + + + + +E G SVDW+RE +T L S+ + F++L KG
Sbjct: 114 ITWEWANK------YRREIREQIKALGASVDWTRERFT--LDEGLSRAVRKVFVELYRKG 165
Query: 175 YIVKGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPET 234
I +G + V W P T L D ++ E L YV K+ +K+ DE Y+ AT RPET
Sbjct: 166 LIYRGKYIVNWCPRCKTVLSDEEVEHKEHKSKLYYV--KYPVKDSDE--YIVVATTRPET 221
Query: 235 VYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGK 294
+ G T + ++P E+ + + +GK
Sbjct: 222 MLGDTAVAVHP--------------------------------------EDERYKNFVGK 243
Query: 295 YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPR 354
+ P+ G E+ ++ ++VDP TG V PAH P D++ + + ++ +D + R
Sbjct: 244 TLILPLVGREIPVVADKYVDPKFGTGAVKVTPAHDPNDYLIAQ--RHNLPMIEIFDDNAR 301
Query: 355 IVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTI 400
I E K +G + A E++ K ++ Q K+E T ++
Sbjct: 302 INENGG-----KYKGLDRYEAREKIVK-DLEEQGFLVKIEDYTHSV 341
Score = 115 bits (284), Expect = 3e-24
Identities = 100/361 (27%), Positives = 163/361 (44%), Gaps = 29/361 (8%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMS 652
E E+ + +YP D +G D+I + I ++ + G+KMS
Sbjct: 466 EETEDLKRYYPTDLLVTGFDIIFFWVARMIMMGYEFMNDKPFSHVYIHQLVRDKYGRKMS 525
Query: 653 KSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSD-------FDWRRKEVGKLRRQLERFY 705
KS GN ++ ++ I+E GAD +R + LA D FD +K K+ RF
Sbjct: 526 KSLGNGIDPLEVIDEYGADPMRFTLAILAAQGRDIKLDPRYFDAYKKFANKIWNAT-RF- 583
Query: 706 ELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL- 764
++ +Y+ LKT+DKW+L RLNK +E T ALE + A + + +D
Sbjct: 584 -VLMNLEDYKEVPLENLKTVDKWILTRLNKTVEEVTNALENYDFNIAARTIYNFFWDDFC 642
Query: 765 RWYMRRTEGRDDEAKR----FVLRKLADIWVRLMAPFTPHICEELWEKLGGEG-FVSLAK 819
WY+ ++ R +R VL K+ D +RL+ PF P + EELW+KL G +++AK
Sbjct: 643 DWYIEASKPRLKTEERNLVQTVLVKVLDASLRLLHPFMPFLTEELWQKLPVAGESITIAK 702
Query: 820 WPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAE 879
WPE E +E E E + +++ ++ + + +R +Y K YEV E
Sbjct: 703 WPEIERELIDETAEKEFTRLMNMVRGVRNVRAEMNLPQSQRVKVYI------KGYEVTEE 756
Query: 880 KREFKSAMAELMKDEEIRKHGKEVAKLVQAIIKERA---FDV-KRIDEEKVLRESKDFLE 935
+ + + EE+ ++ K A ++E D+ ID EK K +E
Sbjct: 757 EELLLKTLGNI---EEVSFVNEKPPKTATAYVEEEIEAYVDLGGLIDFEKEKERLKQIME 813
Query: 936 K 936
K
Sbjct: 814 K 814
>pir||E83148 leucyl-tRNA synthetase PA3987 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950178|gb|AAG07374.1|AE004816_10
(AE004816) leucyl-tRNA synthetase [Pseudomonas
aeruginosa]
Length = 873
Score = 128 bits (319), Expect = 3e-28
Identities = 120/482 (24%), Positives = 199/482 (40%), Gaps = 113/482 (23%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE + Q W E + F +++ P ++KFY FPY SG LH+GH R YTI DVI+R+ R
Sbjct: 10 IETQAQNYWKEHQSFL--VRELPDKEKFYCLSMFPYPSGKLHMGHVRNYTIGDVISRYHR 67
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
MQG NVL PMGW G P A +KN W Y ++
Sbjct: 68 MQGRNVLQPMGWDAFGMPAENAA--MKNNVAPAAWTYDNI-------------------A 106
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+MK+ ++ G ++DWSRE T+ P + ++ +W F +L EKG I + V WDPV
Sbjct: 107 YMKSQLDSL---GLAIDWSRE--VTTCKPDYYRWEQWLFTRLFEKGVIYRKNGTVNWDPV 161
Query: 189 VGTPLGDHDLMEG-----------EDVPILEYVIIKFELKEGDETIYLPAATLRPETVYG 237
T L + +++G ++P+ + I + + + LP PE V
Sbjct: 162 DQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITAYAEELLESLDNLPG---WPEQVKT 218
Query: 238 VTNMWINPNA------TYVKAKVKRGGKEETW-----------IISKEAAYKLSFQD--- 277
+ WI + Y +A + G+ + + ++ A + L+ Q
Sbjct: 219 MQRNWIGKSRGMEIGFPYDQASIGHAGQLKVFTTRPDTLMGATYVAVAAEHPLATQAAQN 278
Query: 278 ----------------REIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGV 321
E ++ + K +V +P+TGD++ + A +V + G
Sbjct: 279 DPQLQAFIDECKRGGVAEADIATQEKKGMATSLFVEHPLTGDKLPVWVANYVLMNYGEGA 338
Query: 322 VMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQK 381
VM+VP H +R+ E KY + R V + K+EG +F + +
Sbjct: 339 VMAVPGHD----------ERDFEFANKYGLPIRQV-------IAKVEGDNDFESSVWKEW 381
Query: 382 LGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMY 441
G K +++ T+ + YD Q + I ++ KG+ +
Sbjct: 382 YGAK--------DESVLTVNSGK----------YDNLGYQAAFDAIGADLEAKGLGQART 423
Query: 442 EF 443
+F
Sbjct: 424 QF 425
>dbj|BAB06757.1| (AP001517) valyl-tRNA synthetase [Bacillus halodurans]
Length = 880
Score = 127 bits (315), Expect = 8e-28
Identities = 96/325 (29%), Positives = 156/325 (47%), Gaps = 56/325 (17%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE KW + W+E K FE D+ K K + I + P ++G LH+GHA + D+++R KR
Sbjct: 17 IESKWYEYWIEGKFFEAT-SDETK-KPYTIVIPPPNVTGKLHLGHAWDTALQDILSRLKR 74
Query: 69 MQGYNVLFPMGWHITG-SPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
MQGY+ L+ G G + + +++ + R+ + E W +++
Sbjct: 75 MQGYDTLWLPGMDHAGIATQAKVEAKLREEGKSRYDLGREAF---VEKTWEWKEE----- 126
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+ ++ + + G S+D+SRE +T L SK + F+KL EKG I +G + + WDP
Sbjct: 127 -YADFIRQQWAKLGLSLDYSRERFT--LDEGLSKAVREVFVKLYEKGLIYRGEYIINWDP 183
Query: 188 VVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNA 247
V T L D +++ +DV Y +K+ L +GD I AT RPET+ G T + ++P
Sbjct: 184 VTKTALSDIEVIY-KDVQGYFY-HMKYPLADGDGAI--EVATTRPETMLGDTAVAVHP-- 237
Query: 248 TYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVII 307
E+ + + LIGK V+ P+TG E+ I
Sbjct: 238 ------------------------------------EDERYQHLIGKMVKLPITGREIPI 261
Query: 308 LPAEFVDPDNATGVVMSVPAHAPFD 332
+ ++VD + +G V PAH P D
Sbjct: 262 VADDYVDMEFGSGAVKITPAHDPND 286
Score = 94.4 bits (231), Expect = 5e-18
Identities = 108/411 (26%), Positives = 180/411 (43%), Gaps = 62/411 (15%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGF-GTLEGQKM 651
E +++ +Y D +G D+I ++ IF + + + K + ++G EGQKM
Sbjct: 468 EEAPDYKRYYSTDALVTGYDIIFFWVSRMIFQGLEFTGQPPF-KDVLIHGLVRDAEGQKM 526
Query: 652 SKSKGNVLNFIDAIEENGADVVRLYIM--SLAEHDSDFDWRRKE----VGKLRRQLERFY 705
SKS GN ++ ++ I++ GAD +R ++ S +D F W + E G RF
Sbjct: 527 SKSLGNGVDPMEVIDKYGADALRFFLATGSSPGNDLRFYWEKVESTWNFGNKIWNASRFA 586
Query: 706 ELISQFAEYEAKENVELKTI-DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL 764
+ Y+ + K+I D+W+L RL + IE T+ ++ + + + I +DL
Sbjct: 587 LMNMDGMSYDEIDLTGEKSIADQWILTRLQETIETVTRLIDAYEFGEVGRHLYNFIWDDL 646
Query: 765 -RWYMRRTE----GRDDEAK---RFVLRKLADIWVRLMAPFTPHICEELWEKLGGEG-FV 815
WY+ + G D+ AK R VL + D +RL+ P P I EE+W+ L EG +
Sbjct: 647 CDWYIEMAKLPLYGEDEVAKKTTRSVLAYVLDQTMRLLHPLMPFITEEIWQHLPHEGESI 706
Query: 816 SLAKWPEPVDEWWNEEVEVEEDFIKSLI--------------------------EDIKEI 849
++A WP +E+ E+ + + +K +I ED+
Sbjct: 707 TVASWPVKSEEFTFEQAMGDMELLKDIIRSVRNTRAELNVPMSKEIELHIQAKNEDVLTQ 766
Query: 850 IE-----VAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMK-DEEIRKHGKEV 903
+E + K +P + TA E K V E +A L+ +EEI + KE
Sbjct: 767 LERGKHYIEKFCNPSTLVMGTAIEKPEKSMSNVLSGVELYLPLAGLLDLEEEIARLEKEE 826
Query: 904 AKL------VQAIIKERAFDVKRIDEEKVLRESK----DFLEKELGLEVII 944
KL VQ + + F K EKV+ E + D+LEK + I
Sbjct: 827 NKLEKEVERVQKKLSNQGFLAKA--PEKVIEEERKKEADYLEKRAAVRARI 875
>gb|AAG20349.1| (AE005108) leucine-tRNA synthetase; LeuS [Halobacterium sp. NRC-1]
Length = 885
Score = 126 bits (313), Expect = 1e-27
Identities = 110/376 (29%), Positives = 160/376 (42%), Gaps = 92/376 (24%)
Query: 8 AIEEKWQKRWLEAKVFE-PNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARF 66
AIE+ WQ+ W +A VF P+ D P+ Y+ FPY SG LH+GH R Y I D AR+
Sbjct: 11 AIEQHWQREWDDADVFRVPDDADDPE----YVLAMFPYTSGQLHMGHVRNYAITDAFARY 66
Query: 67 KRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIV 126
+RM G +VL PMGW G P A RD + P E WT
Sbjct: 67 RRMDGEDVLHPMGWDSFGLPAENAA---NERDTN-----------PRE--WT-------- 102
Query: 127 KYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWD 186
+ + ++ F GF DW RE T+ P + K+ +W F + ++ G + + A V W
Sbjct: 103 ERCIDQMRDQFEALGFGYDWEREI--TTCDPDYYKWNQWLFTEFRDAGLVDRRAATVNWC 160
Query: 187 PVVGTPL------GDHDLMEGEDVPILEYVIIKF---------ELKEG-DE--------- 221
P T L GD +L D P+ E + ++ EL +G DE
Sbjct: 161 PSCETVLADEQVEGDDELCWRCDTPVTERDLDQWFFETTAYADELLDGLDELDGWPSNVR 220
Query: 222 -----------------TIYLP-------AATLRPETVYGVTNMWINPNATYVKAKVKRG 257
T++ P A T R +T++G T + P+ +A R
Sbjct: 221 DMQRNWVGRTDGVEVPFTVHTPDGDEDVVAFTTRVDTIHGATYFALAPDHPLAEAAADRD 280
Query: 258 GKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDN 317
++ +E A + + +E EF NP TG E+ ++ A+FV D
Sbjct: 281 DDVAHFV--EEVADPDGDEPQGVET--EFT--------ATNPATGAEIPVVVADFVLSDV 328
Query: 318 ATGVVMSVPAHAPFDH 333
TG +M+VPAH DH
Sbjct: 329 GTGALMAVPAHDDRDH 344
Score = 125 bits (310), Expect = 3e-27
Identities = 110/382 (28%), Positives = 176/382 (45%), Gaps = 31/382 (8%)
Query: 601 WYPLDWRCSGKDLIPNHLTFFIFNHVAI----FREEHWP-KGIAVNGFGTLE-GQKMSKS 654
W P+D G + HL + F A E P G+ G E G KMSKS
Sbjct: 516 WLPVDEYVGGDEHAVMHLLYSRFVTKAFADLDMLEHREPFAGLTTQGMVLGEDGTKMSKS 575
Query: 655 KGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEY 714
K N + ++E GAD RL+ + A F W + V LER + ++
Sbjct: 576 KDNGVAPERIVDEYGADTARLFTLRAARPSKAFPWSEEGVRSSHTFLERLLSM-ARAVNA 634
Query: 715 EAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGR 774
+A + +L +++ ++ T ++ AVQ +++L + R R
Sbjct: 635 DATADGDLDPAAEYVARETAATVQAATTHFDDMEFNRAVQ-----AVDELVSLLVRYRDR 689
Query: 775 DDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEV 834
DD A V R + V+L+AP PH+ EE W LGG+GFV+ A WP P + +V
Sbjct: 690 DDAAPAVVARGVTAA-VKLLAPIAPHVAEECWTALGGDGFVAEAAWPTP-----DRDVS- 742
Query: 835 EEDFIKSLI----EDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAE-KREFKSAMAE 889
+ D SLI ED+++I++ A IE+P + TAPEW +Y+V+A K + +
Sbjct: 743 DHDRATSLIEQTREDVRDIVDTAGIENPTGVDVVTAPEW---MYDVLARAKAADGNVVGS 799
Query: 890 LMKDEEIRKHGKEVAKLVQAIIKER-AF-DVKRIDEEK-VLRESKDFLEKELGLEVIINP 946
+M D+ +++HG++ A + + + AF DV D E+ L + LE E V +
Sbjct: 800 VMSDQSLQQHGEDAADYAKDLAAQAPAFPDVLGPDGERDALGRAVWLLEAEFDAPVRVLA 859
Query: 947 EEDKGGK-KRQAIPLKPAVFIE 967
ED +A P +PA+ ++
Sbjct: 860 AEDAADSVANKAEPGRPAIHVD 881
>pir||D71457 valine--tRNA ligase (EC 6.1.1.9) - Pyrococcus horikoshii
>gi|3256704|dbj|BAA29387.1| (AP000001) 896aa long
hypothetical valyl-tRNA synthetase [Pyrococcus
horikoshii]
Length = 896
Score = 125 bits (311), Expect = 2e-27
Identities = 109/389 (28%), Positives = 177/389 (45%), Gaps = 72/389 (18%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE KWQK WLE K+++ + + + + I P+ SG LH+GH ++T D+IAR+KR
Sbjct: 16 IEPKWQKYWLEEKIYKYRLDEN--KPSYAIDTPPPFTSGTLHLGHVLSHTWIDIIARYKR 73
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEIL-----WTFEDPV 123
M+GYNVLFP G+ G P E+ I +D PEE L WT++
Sbjct: 74 MRGYNVLFPQGFDNHGLPTELKVEK-------EFGITKD---QPEEFLKKCVEWTWQ--- 120
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
++A ++ FIR G+S DW E++T + + ++ L+ +KG I + H V
Sbjct: 121 -----AIEAMRKQFIRIGYSADWDLEYHTMDDW--YKAAVQRSLLEFYKKGLIYREEHPV 173
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWI 243
W P T L ++ E+ L Y IK L +G Y+P AT RPE + +++
Sbjct: 174 YWCPKCRTSLAKAEVGYVEEEGYLYY--IKLPLADGSG--YIPIATTRPELMPACVAVFV 229
Query: 244 NPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGD 303
+P+ + YK L+GK V+ P+
Sbjct: 230 HPD---------------------DERYK-----------------HLVGKKVKLPIFER 251
Query: 304 EVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYIS 363
EV IL E VDP+ TG V + D V + + +++ + D + E +
Sbjct: 252 EVPILADEDVDPNFGTGAVYNCTYGDEQDIVWQK--RYNLPVIIVINEDGTMNENAGPYA 309
Query: 364 LIKLEGYGEFPAVEEVQKLGIKSQKDREK 392
+K+E E+++K+G+ +K++ K
Sbjct: 310 GLKIE-EARKKIAEDLEKMGLLYKKEKIK 337
Score = 116 bits (288), Expect = 1e-24
Identities = 131/479 (27%), Positives = 223/479 (46%), Gaps = 73/479 (15%)
Query: 414 PYDGKPVQEVKELIAKEMMEKGIAEIMYEFAE-KNVISRFGNR----AVIKII-HDQWFI 467
PY G ++E ++ IA+++ + G+ +Y+ + K+ + R R A I+++ QWFI
Sbjct: 307 PYAGLKIEEARKKIAEDLEKMGL---LYKKEKIKHRVLRHTERSSCMAPIELLPKKQWFI 363
Query: 468 DYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKK----ACARKVGLGTPLPWDPE 523
+ ++ K + YPE F + DW + +R+ GTP P+
Sbjct: 364 KV--KDLIDEIIKVAKEINWYPED---MFLRLKDWAESMDWDWVISRQRVFGTPFPF--- 415
Query: 524 WVIESLSDSTIYMAYYTISRHINRLREEGR-LDPEKLTPEFFDYIFLEEFSEEREKELE- 581
WV ++ HI REE +DP P E L+
Sbjct: 416 WVCKN--------------GHIIPAREEDLPVDPRFDKPPVDKCPVCGAEIEPVTDVLDC 461
Query: 582 -KKTGIPAEII----------HEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFR 630
+ I II E K+ FE+ +P R G D+I + I +
Sbjct: 462 WVDSSITPLIITKWHEAIKGDEEAKKWFEHNFPTALRPQGTDIIRTWAFYTILRTYVLTG 521
Query: 631 EEHWPKGIAVNGF-GTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDW 689
++ W K I +NG +G+KMSKS GNV++ + I + GAD +RL+ +LA D +
Sbjct: 522 KKPW-KDIVINGMVAGPDGRKMSKSYGNVVSPEEVIPKYGADALRLWT-ALAPPGEDHPF 579
Query: 690 RRKEVGKLRRQLERFYELISQFAE-------YEAKENVELKTIDKWLLHRLNKAIEGTTK 742
+ + V R L++ + I +FAE YE +VEL+ +DKW+L RL++ I+ T+
Sbjct: 580 KWETVDYNYRFLQKVWN-IYRFAERHIKDFDYEKYRDVELEPLDKWILSRLHRIIKFATE 638
Query: 743 ALEEFR----TRTAVQWAFYSIMND-LRWYMRRTEGRDDEAK---RFVLRKLADIWVRLM 794
LE +R TR + + ++ + +D + R G D+E+K + L +L + L+
Sbjct: 639 ELERYRFNLITRELITFIWHEVADDYIEMIKYRLYGEDEESKLKAKVALYELLYNVMLLL 698
Query: 795 APFTPHICEELW-----EKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKE 848
APF PHI EE++ EK+ GE V L WPE ++ +EE E + + ++ ++++
Sbjct: 699 APFVPHITEEIYHAIFKEKI-GEKSVHLLSWPEYREDRIDEEAEKIGELARKIVSEMRK 756
>pir||G75014 valyl-tRNA synthetase (vals) PAB1255 - Pyrococcus abyssi (strain
Orsay) >gi|5459071|emb|CAB50557.1| (AJ248288) valyl-tRNA
synthetase (valS) [Pyrococcus abyssi]
Length = 891
Score = 125 bits (311), Expect = 2e-27
Identities = 109/389 (28%), Positives = 177/389 (45%), Gaps = 72/389 (18%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE KWQK WLE K+++ + + + + I P+ SG LH+GH ++T D+IAR+KR
Sbjct: 11 IEPKWQKYWLEEKIYKYRLDEN--KPSYAIDTPPPFTSGTLHLGHVLSHTWIDIIARYKR 68
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEIL-----WTFEDPV 123
M+GYNVLFP G+ G P E+ I +D PEE L WT++
Sbjct: 69 MRGYNVLFPQGFDNHGLPTELKVEK-------EFGITKD---QPEEFLKKCVEWTWQ--- 115
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
++A ++ FIR G+S DW E++T + + ++ L+ +KG I + H V
Sbjct: 116 -----AIEAMRKQFIRIGYSADWDLEYHTMDDW--YKAAVQKSLLEFYKKGLIYREEHPV 168
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWI 243
W P T L ++ E+ L Y IK L +G Y+P AT RPE + +++
Sbjct: 169 YWCPKCRTSLAKAEVGYVEEEGYLYY--IKLPLADGSG--YIPIATTRPELMPACVAVFV 224
Query: 244 NPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGD 303
+P+ + YK L+GK V+ P+
Sbjct: 225 HPD---------------------DERYK-----------------HLVGKKVKLPIYER 246
Query: 304 EVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYIS 363
EV IL E VDP+ TG V + D V + + +++ + D + E +
Sbjct: 247 EVPILADEDVDPNFGTGAVYNCTYGDEQDIVWQK--RYNLPVIIAINEDGTMNENAGPYA 304
Query: 364 LIKLEGYGEFPAVEEVQKLGIKSQKDREK 392
+K+E E+++K+G+ +K++ K
Sbjct: 305 GLKVE-EARKKIAEDLEKMGLLYKKEKIK 332
Score = 113 bits (281), Expect = 7e-24
Identities = 128/478 (26%), Positives = 223/478 (45%), Gaps = 71/478 (14%)
Query: 414 PYDGKPVQEVKELIAKEMMEKGIAEIMYEFAE-KNVISRFGNR----AVIKII-HDQWFI 467
PY G V+E ++ IA+++ + G+ +Y+ + K+ + R R A I+++ QWFI
Sbjct: 302 PYAGLKVEEARKKIAEDLEKMGL---LYKKEKIKHRVLRHTERSSCMAPIELLPKKQWFI 358
Query: 468 DYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKK----ACARKVGLGTPLPWDPE 523
++ ++ K + YPE F + DW + +R+ GTP P+
Sbjct: 359 RV--KDFTDEIVKVAKEINWYPED---MFLRLKDWAESMDWDWVISRQRVFGTPFPF--- 410
Query: 524 WVIESLSDSTIYMAYYTISRHINRLREEGR-LDPEKLTPEFFDYIFLEEFSEEREKELE- 581
WV ++ HI REE +DP P E L+
Sbjct: 411 WVCKN--------------GHIIPAREEDLPVDPRFDKPPVEKCPVCGAEIEPVTDVLDC 456
Query: 582 -KKTGIPAEII----------HEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFR 630
+ I II E K+ FE+ +P R G D+I + IF +
Sbjct: 457 WVDSSITPLIITRWHEAIKGDEEAKKWFEHNFPTALRPQGTDIIRTWAFYTIFRTFKLTG 516
Query: 631 EEHWPKGIAVNGF-GTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDW 689
++ W K I +NG +G+KMSKS GNV+ + I + GAD +RL+ +LA D +
Sbjct: 517 KKPW-KDIVINGMVAGPDGRKMSKSYGNVVAPDEVIPKYGADALRLWT-ALAPPGEDHPF 574
Query: 690 RRKEVGKLRRQLERFYELISQFAE-------YEAKENVELKTIDKWLLHRLNKAIEGTTK 742
+ + V R L++ + I +FAE YE +++EL+ +D+W+L RL++ I+ T+
Sbjct: 575 KWETVDYNFRFLQKVWN-IYRFAERHIKDFDYEKYKDIELEPLDRWILSRLHRIIKFATE 633
Query: 743 ALEEFR----TRTAVQWAFYSIMND-LRWYMRRTEGRDDEAK---RFVLRKLADIWVRLM 794
LE +R TR + + ++ + +D + R G D+E+K + L +L + L+
Sbjct: 634 ELERYRFNLITRELMTFIWHEVADDYIEMVKYRLYGDDEESKLKAKVALYELLYNVMLLL 693
Query: 795 APFTPHICEELWEKLG----GEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKE 848
APF PHI EE++ + GE V L WPE ++ +E+ E + + ++ ++++
Sbjct: 694 APFVPHITEEIYHAMFKDKIGEKSVHLLSWPEYREDRIDEKAEKLGELARKVVSEMRK 751
>sp|P57447|SYV_BUCAI VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|10039036|dbj|BAB13070.1| (AP001119) valyl-tRNA
synthetase [Buchnera sp. APS]
Length = 955
Score = 124 bits (309), Expect = 4e-27
Identities = 204/935 (21%), Positives = 366/935 (38%), Gaps = 200/935 (21%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N + IEE W + F+PN +K F I + P ++G LH+GHA TI D++
Sbjct: 6 NPKHIEESLYFFWEKNGFFKPNHLEK---STFCIMMPPPNITGSLHMGHAFQQTIMDILI 62
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIY-RDVYKVPEEILWTF-ED 121
R+ RMQG N + +G G + ER I ++ T Y RD + + +W + +
Sbjct: 63 RYHRMQGKNTFWQVGTDHAGIATQILVERQIFEKEQKTKKDYSRDDF---IKKIWEWKKQ 119
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAH 181
NI+ M+ R G SVDW E +T L P S + F+ L + I +
Sbjct: 120 SSNIITKQMR-------RLGISVDWDYEKFT--LDPDISNSVREAFIILYKNNLIYQKKK 170
Query: 182 RVRWDPVVGTPLGD----HDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYG 237
V WD + T + D H L++G+ + Y II+ ++ + YL +T RPET+ G
Sbjct: 171 LVHWDSKLETVISDLEVEHRLIKGKKW-FIRYPIIENDMSLRSKVKYLIVSTTRPETLLG 229
Query: 238 VTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVR 297
T + +NP E++K + IG +V
Sbjct: 230 DTAIAVNP--------------------------------------EDYKYNQFIGNHVS 251
Query: 298 NPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVE 357
P+T + I+ + D + TG V PAH D+ L + ++ + D RI
Sbjct: 252 CPLTNRIIPIIKDRYADLEKGTGCVKITPAHDFNDYKV--GLHHKLPMINIFTFDGRIK- 308
Query: 358 EITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDG 417
S ++ Y EK Q + I H I
Sbjct: 309 -----STAEVYNY------------------KGEKSNQYSTCIPMQFQHLDILSA----- 340
Query: 418 KPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKI---IHDQWFIDYGNSEW 474
++ +KE+ +EK E NV + R+ + I + +QW++ S
Sbjct: 341 -RIEIIKEITKLGFLEK--------IEECNVTVPYSERSGVIIEPMLTNQWYLK--TSTL 389
Query: 475 KEKARKAL--ARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP-W--DPEWVIESL 529
+ A A+ ++K P+ + + + ++ ++ +R++ G +P W D + +
Sbjct: 390 AKVALNAVKDKKIKFIPQQYESMYSSWMNNIEDWCISRQLWWGHRIPVWYDDQKNIYIGQ 449
Query: 530 SDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAE 589
++ I A Y+IS ++ L++E + D F KKT
Sbjct: 450 NEKEIRQA-YSISENV-LLKQEN---------DVLDTWFSSGLWTFSSLGWPKKTTF--- 495
Query: 590 IIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWP-----KGIAVNGFG 644
+ ++P + SG D+I + I + +++H K I + G
Sbjct: 496 --------LKTFHPTNVLVSGFDIIFFWIARMIMLTMYFMKDKHNNPEVPFKNIYITGLI 547
Query: 645 TLE-GQKMSKSKGNVLN-------------------------------------FIDAIE 666
E G+KMSKSKGNV++ F + I+
Sbjct: 548 RDEFGKKMSKSKGNVIDPLDMIDGISLSELIKKRTNNLLQPNLSDKIIQRTIKQFPEGIK 607
Query: 667 ENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRR------QLERFYELISQ---FAEYEAK 717
G D +R +LA D W + R RF + +Q F++++ K
Sbjct: 608 STGTDALRFTFSALASSTRDIQWDMNRLKGYRNFCNKLWNASRFVLINTQDHNFSKFDVK 667
Query: 718 ENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RWYM-------R 769
+ L I+KW+L N ++ ++L+ +R A + I N WY+ +
Sbjct: 668 RKMLL--INKWILIEFNNTVKLYRESLDTYRFDIAANILYDFIWNIFCDWYLEFVKIVIK 725
Query: 770 RTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLG-----GEGFVSLAKWPEPV 824
++ + VL + ++ ++L P P I E +W+++ E + L +PE
Sbjct: 726 LGSSKEVYCTKNVLVYVLELLLKLAHPIMPFITETIWQRIKLIQNISEKTIMLQDFPEYN 785
Query: 825 DEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPK 859
+ +++++ V+ +++K +I ++ I + S K
Sbjct: 786 HKLFDKKILVQMNWMKKIIVFLRNIRTNMNVSSTK 820
>sp|O51680|SYV_BORBU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437647|pir||A70192 valine--tRNA ligase (EC 6.1.1.9)
valS - Lyme disease spirochete
>gi|2688666|gb|AAC67078.1| (AE001173) valyl-tRNA
synthetase (valS) [Borrelia burgdorferi]
Length = 875
Score = 124 bits (309), Expect = 4e-27
Identities = 179/855 (20%), Positives = 335/855 (38%), Gaps = 171/855 (20%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARF 66
+A E++ +WL+ VF P D +KF + P ++G LH+GHA + + DV+ R+
Sbjct: 12 KAFEDEIYTKWLKNNVFLP---DNSLFEKFSMVAPPPNVTGVLHMGHALNFVLQDVLVRY 68
Query: 67 KRMQGYNVLFPMGWHITGSPIVGIAERIKNR------DPHTIWIYRDVYKVPEEILWTFE 120
KRM+ +N L+ G G + ER + D + ++++K+ +
Sbjct: 69 KRMKRHNTLWLFGTDHAGIATQAVFERHLKKIGKSKDDFEREELVQEIFKLKDRHRGIIV 128
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
+ +N + G S D SRE +T L K + F L KG I +G
Sbjct: 129 NQIN--------------KLGASYDHSRERFT--LDENLCKAVNKVFKDLYFKGLIYRGE 172
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
+ V DP G+ + D ++ E ++V Y + F D + ++ AT RPET++G T
Sbjct: 173 YLVNLDPGSGSVVSDEEI-EYKEVDGKLYFVKYFI----DNSSFIEVATTRPETMFGDTA 227
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
+ +NPN + YK L+GK V P+
Sbjct: 228 IAVNPN---------------------DERYK-----------------SLVGKEVTIPL 249
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEIT 360
T ++ ++ +VD TG + PAH P D ++I R I+
Sbjct: 250 TTKKIKVIADFYVDSAFGTGALKVTPAHDPND----------------FEISKR--HNIS 291
Query: 361 YISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVP-PYDGKP 419
++++ +G KL + VP Y G
Sbjct: 292 KVNILTQDG----------------------KLNK---------------NVPLQYQGLS 314
Query: 420 VQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKAR 479
++ + I E+MEKG + + + ++ + + QWF+ +KA
Sbjct: 315 AKDARFKIETELMEKGFLQDVKKHKQQVGHCYRSGEVIEPYLSTQWFVRM--KPLADKAL 372
Query: 480 KAL--ARMKIYPE----TRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDST 533
KAL +K YP+ T + I DW +R++ G +P V ++ S
Sbjct: 373 KALENGELKFYPKKWENTYKYWLSNIRDW----CISRQLVWGHRIP-----VWYNVDTSE 423
Query: 534 IYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHE 593
+ ++ S + + DP+ L F +++ FS G P
Sbjct: 424 LIVSDTDPSLDEKNMGKRFVQDPDVLDTWFSSWLW--PFS---------SLGWP-----N 467
Query: 594 MKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSK 653
+ +F+ +YP + + D+I + + + + + +G+KMSK
Sbjct: 468 VDVDFKNYYPTNTLITAYDIIFFWVARMVMAGLEFTGQVPFKDVYITPLLRDKQGKKMSK 527
Query: 654 SKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE----LIS 709
S GN ++ +D I E G+D +R + L+ D + K+ + + + ++
Sbjct: 528 SLGNGIDPLDIINEYGSDSLRFTLSFLSVQGQDLNIDAKDFMFGAKFANKVFNASKFILL 587
Query: 710 QFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RWYM 768
+ +++ IDKWLL LN I G + ++ A ++ + ND WY+
Sbjct: 588 NLKNRKILNDLKFNDIDKWLLTSLNSTILGVESSFANYKYNEASKFVYEFFWNDFCDWYI 647
Query: 769 RRTE----GRDDEAKRFVLRKLADIWVR---LMAPFTPHICEELWEKLG-GEGFVSLAKW 820
++ + + + + KL + ++ PF P + E+++ + E ++L ++
Sbjct: 648 EISKIDLNNENVDIQNMAISKLLFFLKKSLLILHPFIPFVTEKIYSEFAEKEDILALNEY 707
Query: 821 PE-PVDEWWNEEVEV 834
P + + EE E+
Sbjct: 708 PNFDIANNFQEEFEI 722
>pir||G82260 leucyl-tRNA synthetase VC0956 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9655415|gb|AAF94118.1| (AE004177)
leucyl-tRNA synthetase [Vibrio cholerae]
Length = 894
Score = 124 bits (309), Expect = 4e-27
Identities = 115/400 (28%), Positives = 157/400 (38%), Gaps = 98/400 (24%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
+ N + IE K Q+ W K F + + P ++KFY FPY SG LH+GH R YTI DV
Sbjct: 40 QYNPQDIEHKVQQHWDNNKTFV--VSEDPNKEKFYCLSMFPYPSGRLHMGHVRNYTIGDV 97
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDP 122
++RF+R+QG NVL P+GW G P A +KN W Y ++
Sbjct: 98 VSRFQRLQGKNVLQPIGWDAFGLPAENAA--VKNNTAPAPWTYENI-------------- 141
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
+ K GF DW+REF T P + ++ + F KL KG + K
Sbjct: 142 --------EYMKNQLKLLGFGYDWNREFATCR--PEYYRWEQEFFTKLFAKGLVYKKTSS 191
Query: 183 VRWDPVVGTPLGDHDLMEG----EDVPI-------------------------------- 206
V W P T L + + +G D P+
Sbjct: 192 VNWCPNDQTVLANEQVEDGCCWRCDTPVEQKEIPQWFIKITAYAQELLDDLDNLDGWPEM 251
Query: 207 -----------LEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWI---NPNATYVKA 252
E V +KF +K E L T RP+T+ GVT + I +P AT
Sbjct: 252 VKTMQRNWIGRSEGVELKFAVK--GENTDLEVYTTRPDTLMGVTYVGIAAGHPLAT---- 305
Query: 253 KVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEF 312
K + + EI +E K G +P+ G EV I A F
Sbjct: 306 --KAAANNPALAAFIDECKNTKVAEAEIATME--KKGMATGLTAIHPLNGREVPIYIANF 361
Query: 313 VDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDID 352
V D TG VM+VPAH +R+ E KY +D
Sbjct: 362 VLMDYGTGAVMAVPAHD----------QRDFEFATKYGLD 391
Score = 71.4 bits (172), Expect = 5e-11
Identities = 52/175 (29%), Positives = 81/175 (45%), Gaps = 9/175 (5%)
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKSK N ++ + +++ GAD VRL++M + D +W+ V R L R ++L+
Sbjct: 654 KMSKSKNNGIDPQEMVDKYGADTVRLFMMFASPADMTLEWQESGVEGANRFLRRVWKLVR 713
Query: 710 QFAEY---EAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW 766
+ E A + L K L ++K I T + +T A +MN L
Sbjct: 714 EHTELGQAPALDASALNADQKALRRDVHKTIAKVTDDVARRQTFNTAIAAIMELMNKLT- 772
Query: 767 YMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
TE +D R +L + ++ P TPHIC E+W L G+ + A WP
Sbjct: 773 KAPMTEAQD----RAILDEALKAITLMLYPITPHICFEMWVAL-GQSNIDTASWP 822
>pir||E75554 valyl-tRNA synthetase - Deinococcus radiodurans (strain R1)
>gi|6457813|gb|AAF09735.1|AE001877_2 (AE001877)
valyl-tRNA synthetase [Deinococcus radiodurans]
Length = 913
Score = 122 bits (302), Expect = 3e-26
Identities = 196/897 (21%), Positives = 339/897 (36%), Gaps = 188/897 (20%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKK-FYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
IE KW RW EP D K F I + P ++G+LH+GHA T+ D + R+K
Sbjct: 18 IEPKWAARWRS----EPFRADATSGKDPFTIVIPPPNVTGNLHLGHALDNTLIDTLIRYK 73
Query: 68 RMQGYNVLFPMGWHITG-SPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIV 126
RM G+ L+ G G S V + ++K+ + R+ + E +W ++
Sbjct: 74 RMAGFEALYLPGMDHAGISTQVVVERQLKDAGTSRHDLGREAFL---EKVWEWKGKSG-- 128
Query: 127 KYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWD 186
+ R G S DW+RE +T + S+ + QF+KL G +G V WD
Sbjct: 129 ----GMILDQLTRLGVSADWTRERFT--MDEGLSRAVRTQFVKLYHDGLAYRGERIVNWD 182
Query: 187 PVVGTPLG----DHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMW 242
P T L D ++ +G+ + + E ET + AT+RPET++ +
Sbjct: 183 PASQTTLSELEIDREVRKGKMYTLSYKLENSAERGSNGETGEIRIATVRPETIFADQAIA 242
Query: 243 INPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTG 302
++P E+ + L+G+ R P+T
Sbjct: 243 VHP--------------------------------------EDERFRHLVGQKARIPLTD 264
Query: 303 DEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALE--DLKRESEILVKYDIDPRIVEEIT 360
V I+ E V+ + G + PAH P D E L+R S I D+D + +
Sbjct: 265 RWVPIIADEAVEMEFGVGALKITPAHDPTDFEVGERHGLERPSVI----DLDGNLTRD-- 318
Query: 361 YISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGI-----FKVPPY 415
+ + +G F A + V K LE++ + + ++ I KVP
Sbjct: 319 ELVPAEFQGLERFAARKAVVK----------ALEESGDLLEQKDHDTAIGLSERTKVP-- 366
Query: 416 DGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWK 475
V+ +I+++ K M FA++ + ++ IK++ +++ N +W
Sbjct: 367 -------VEPIISEQWFVK-----MKPFADQ--VLEGLDKGEIKLVPERY--TKVNRDWL 410
Query: 476 EKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIY 535
E R +++ I W DK+ + P P +PE ++ D
Sbjct: 411 ENIRDWNISRQLW------WGHQIPAWYDKEG-----NIYVPDPENPE--LDCDQDPRY- 456
Query: 536 MAYYTISRHINRLREEGRLDPEKLTPEFFDYIF---LEEFSEEREKELEKKTGIPAEIIH 592
H+N R+ P+ FD F L FS + +
Sbjct: 457 -------AHLNLRRD----------PDVFDTWFSSNLWPFSTLGWPDTD----------- 488
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMS 652
E+F +YP +G D++ + + + + + + +GQKMS
Sbjct: 489 --SEDFRKFYPTQVLVTGYDILFFWVARMQMAGYGLTGQAPFSTVMLHGLYLDAKGQKMS 546
Query: 653 KSKGNVLNFIDAIEENGADVVR--LYIMSLAEHDSDFDWRRKEVGK-------------L 697
KSKGN ++ ++ + G D R +S D D RR E G+ L
Sbjct: 547 KSKGNGIDPLELFGQYGVDACRFAFTFLSTGGQDIKHDARRFEQGRNFANKLWNATRFAL 606
Query: 698 RRQLERFYELISQFAEY--------------------EAKENVELKTIDKWLLHRLNKAI 737
R E E + Y + KE +L D+W++ RLN
Sbjct: 607 MRLGEARIEGSDDLSAYVRAAVTLPDGVLLRSKDVLAQLKERDDLTLADRWIISRLNDVT 666
Query: 738 EGTTKALEEFRTRTAVQWAFYSIMND--LRWYMRRTE---GRDDEAKRFVLRKLADIWVR 792
+ L+ F A++ YS D WY+ + + L+ + + ++
Sbjct: 667 AEASAQLDAFDIGAAIR-TLYSFTWDEFCDWYIEAAKPELASGNLGTMATLKVVLEHVLK 725
Query: 793 LMAPFTPHICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEI 849
L+ PF P I EL+ LG +++ WP+P + E D ++S ++ + +
Sbjct: 726 LLHPFMPFITSELYAALGHRRQIAVHSWPQPDAALHDAEATKAFDALRSAVDSARSL 782
>sp|Q9ZJ63|SYL_HELPJ LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437531|pir||G71805 leucine--tRNA ligase (EC
6.1.1.4) - Helicobacter pylori (strain J99)
>gi|4156066|gb|AAD07021.1| (AE001567) LEUCYL-TRNA
SYNTHETASE [Helicobacter pylori J99]
Length = 806
Score = 121 bits (301), Expect = 3e-26
Identities = 103/377 (27%), Positives = 164/377 (43%), Gaps = 88/377 (23%)
Query: 4 LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
++F IE+KWQ+ W + K FEP KD K YI PY SG +H+GH R YTI D +
Sbjct: 1 MDFINIEKKWQEFWWKNKSFEP--KDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDAL 58
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
AR+ R+ YNVL PMG+ G P A + P T WT+E+
Sbjct: 59 ARYYRLHHYNVLHPMGFDSFGMPAENAAIK-HGIHPKT---------------WTYEN-- 100
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
++A ++ F GFS +REF T+ P ++KF + F+ L EKG I + +
Sbjct: 101 ------IEAMQKEFEALGFSFSKNREFATSD--PDYTKFEQQFFIDLWEKGLIYRKKAML 152
Query: 184 RWDPVVGTPLGDHDLMEGE----DVPILEYVI---------------------------- 211
W P T L + +++G D +++ +
Sbjct: 153 NWCPNDKTVLANEQVIDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLETLENHWPSQ 212
Query: 212 --------------IKFELKEGDETI-------YLPAATLRPETVYGVTNMWINPNATYV 250
++F K DE + + T R +T+YGVT + I P V
Sbjct: 213 VLTMQKNWIGKSSGLQFGFKIADECLKACNNIQEIEVFTTRADTIYGVTYIAIAPEHPLV 272
Query: 251 KAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPA 310
+ +KR +E++ +I +A + ++R +E K +G Y +P+T ++ + A
Sbjct: 273 EHAIKRVSQEDSKMI--KAILNTTQRERALE-----KKGAFLGIYAIHPLTKQKIPVWVA 325
Query: 311 EFVDPDNATGVVMSVPA 327
F + +G +M VPA
Sbjct: 326 NFALANYGSGALMGVPA 342
>pir||T04047 isoleucine--tRNA ligase homolog F24G24.120 - Arabidopsis thaliana
>gi|4538961|emb|CAB39785.1| (AL049488) isoleucine-tRNA
ligase-like protein [Arabidopsis thaliana]
>gi|7267729|emb|CAB78155.1| (AL161517) isoleucine-tRNA
ligase-like protein [Arabidopsis thaliana]
Length = 1254
Score = 121 bits (301), Expect = 3e-26
Identities = 226/1031 (21%), Positives = 393/1031 (37%), Gaps = 195/1031 (18%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
E +F EE W E F+ +K ++ P+ +G H GH TI D+
Sbjct: 9 EFSFPRQEEDVLSFWTEIDAFKTQLKRTENLPEYIFYDGPPFATGLPHYGHILAGTIKDI 68
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWTF 119
+ R++ M G++V GW G P+ +R IK RD I + D Y
Sbjct: 69 VTRYQTMTGHHVTRRFGWDCHGLPVENEIDRKLNIKRRD-EVIKMGIDKYN--------- 118
Query: 120 EDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKG 179
E+ +IV ++ ++ R G +D+ ++ T L PF + + W F +L EK + +G
Sbjct: 119 EECRSIVTRYVAEWEKVITRCGRWIDFKNDYKTMDL--PFMESVWWVFSQLWEKNLVYRG 176
Query: 180 AHRVRWDPVVGTPLGDHDLMEG-EDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGV 238
+ + TPL + + + ++VP E +++ F + + A T P T+
Sbjct: 177 FKVMPYSTGCKTPLSNFEAGQNYKEVPDPE-IMVTFPVIGDQDNAAFVAWTTTPWTLPSN 235
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREI------------------ 280
+ +N YVK + K GK S+ +A ++
Sbjct: 236 LALCVNAKFVYVKVRNKNTGKVYIVAESRLSALPTDKPKAKLSNGPAGDTKKANPKAKGA 295
Query: 281 ---------EVIEEFKGEKLIGKYVR------NPVTGDEVIILPAEFVDPDNATGVVMSV 325
EV+E+F G L+GK + + + ++ ++V D+ TG+V
Sbjct: 296 KPESAADSYEVLEKFNGASLVGKKYEPLFDYFSDFSSEAFRVVADDYVTDDSGTGIVHCA 355
Query: 326 PAHAPFDH---VALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKL 382
PA D+ + + +K+ ++V D D E IT+ S G + V++ K
Sbjct: 356 PAFGEDDYRVCLLNKIIKKGENLVVAVDDDGLFTERITHFS-------GRY--VKDADKD 406
Query: 383 GIKSQKDREKLEQATKTIYKAEY-----HKGIFKVPPYDGKPVQEVKELIAKEMMEKGIA 437
I++ K + +L + + + I++ P V+++KE + K
Sbjct: 407 IIEAVKAKGRLVKTGSFTHSYPFCWRSDTPLIYRAVPSWFVRVEQLKEKLLK-------- 458
Query: 438 EIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALARMKIYPETRRAQFE 497
S V + D+ F W E AR
Sbjct: 459 ------------SNEQTEWVPGYVKDKRF-----HNWLENAR------------------ 483
Query: 498 AIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTISRHINRLREEGRLDPE 557
DW A +R GTPL P W+ + + I + +L + +
Sbjct: 484 ---DW----AISRSRFWGTPL---PIWISDDGEE-------VVIMDSVEKLEKLSGVKVF 526
Query: 558 KLTPEFFDYIFL-----EEFSEEREKE-----LEKKTGIPAEIIH---EMKEEFEYWYPL 604
L D+I + +EF R E + +P IH E KE FE +P
Sbjct: 527 DLHRHHIDHITIPSSRGDEFGVLRRVEDVFDCWFESGSMPYAYIHYPFENKELFEKNFPG 586
Query: 605 DWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLE-GQKMSKSKGNVLNFID 663
D+ G D + A+F + + K + NG E G+KM+K N ++
Sbjct: 587 DFVAEGLDQTRGWFYTLMVLSTALFEKPAF-KNLICNGLVLAEDGKKMAKKLRNYPPPLE 645
Query: 664 AIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERF------YELISQFAEYEAK 717
I+E GAD VRLY+++ ++ R K+ G L + F Y + Q A+
Sbjct: 646 VIDEYGADAVRLYLINSPVVRAE-PLRFKKEGVLGVVKDVFLPWYNAYRFLVQNAKRLET 704
Query: 718 EN------VELKTI------DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLR 765
E +L TI D+W+ + + ++ +R T V + N
Sbjct: 705 EGGVPFVPTDLATIQSANILDQWIHSATQSLVRFVREEMDAYRLYTVVPRLLKFLDNLTN 764
Query: 766 WYMR----RTEGRDDEAK-RFVLRKLADIWV---RLMAPFTPHICEELWEKL-----GGE 812
Y+R R +GR E L L ++ + ++MAPFTP E L++ L G E
Sbjct: 765 IYVRFNRKRLKGRTGEDDCHTALSTLFNVLLTSCKVMAPFTPFFTETLYQNLRKACKGSE 824
Query: 813 GFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAK--IESPKRAYIYTAPEWK 870
V P P + E +E+ + +I+ + I E K +++P + I P+
Sbjct: 825 ESVHYCSIP-PREGMEGERIELSVTRMMKIIDLARNIRERNKLPLKTPLKEMIVVHPDAD 883
Query: 871 W------KVYEVVAEKREFKSAM--------AELMKDEEIRKHGKEVAKLVQAIIKERAF 916
+ + E V E+ +S + A L + + GK + K + + KE
Sbjct: 884 FLNDITGVLREYVLEELNVRSLVPCNDTLKYASLKAEPDFSVLGKRLGKSMGLVAKE--- 940
Query: 917 DVKRIDEEKVL 927
VK + ++ +L
Sbjct: 941 -VKEMSQKDIL 950
>emb|CAC11189.1| (AL445063) valyl-tRNA synthetase related protein [Thermoplasma
acidophilum]
Length = 791
Score = 120 bits (299), Expect = 6e-26
Identities = 204/929 (21%), Positives = 366/929 (38%), Gaps = 197/929 (21%)
Query: 3 ELNFRAIEEKWQKRWLEAKV--FEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
+++ +EEKW + W E V FEP +DK F I P +SG +H+GH+ +Y
Sbjct: 2 DIDVNQMEEKWIRYWDEKDVYRFEPADRDKV----FAIDTPPPTVSGKMHMGHSFSYPHI 57
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILW 117
D IAR+KRM+GY+V FP G+ G P E+ IK D + + ++ +EI
Sbjct: 58 DFIARYKRMRGYHVFFPWGFDDNGLPTERYVEKETGIKPSDSNV----EEFIRLCKEISE 113
Query: 118 TFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
+ E K+ E + R G S + +++Y TS P + + FL L KG +
Sbjct: 114 SSE----------KSLLEGWKRIGMSC-YFKDYYVTS-SPESIRISQSMFLDLVRKGRVY 161
Query: 178 KGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYG 237
+ P T + ++ + E L Y+ GD L AT RPE +
Sbjct: 162 RDLAPSIRCPTCKTSISQIEMKDQEMHTKLVYI----NFSVGDRP--LTIATTRPEMLGS 215
Query: 238 VTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVR 297
+++NP+ +A Y+ LIGK
Sbjct: 216 CVAVFVNPD---------------------DARYR-----------------DLIGKEAT 237
Query: 298 NPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVE 357
P+ G+ V I+ VD + TG M V + + ++ KY++
Sbjct: 238 VPIFGNHVRIMADASVDMNFGTGAEM----------VCTFGDQNDLDLWKKYNL------ 281
Query: 358 EITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDG 417
L I KD E+A P G
Sbjct: 282 -----------------------PLKISIDKDGRMTEEA----------------GPLKG 302
Query: 418 KPVQEVKELIAKEMMEKGIAEIMYEFAEK---NVISRFGNRAVIKIIHDQWFIDYGNSEW 474
+ + ++ I + + E G ++ E + K N R G I I QWFI Y +
Sbjct: 303 LSISDARKKIVEILREGG--HVVKEESIKHSVNTHERCGTPIEI-FIEKQWFIKY--LDL 357
Query: 475 KEKARKALARMKIYPETRRAQFEAII-----DWLDKKACARKVGLGTPLPWDPEWVIESL 529
K+ + +++ PE R ++E + DWL +R+ G P P W
Sbjct: 358 KDAFIENGRKIEWTPEYMRVRYENWVNGLKWDWL----ISRQRYYGVPF---PVWYCADC 410
Query: 530 SDSTIYMAYYTISRHINRLREEGRLDPEKLTP-EFFDYIFLEEFSEERE-KELEKKTGIP 587
+T+Y E +DP P + D ER+ + + +
Sbjct: 411 G-NTVYAD-----------ESELPVDPRIQKPSKKCDRCGSTNLVPERDVMDTWATSSLT 458
Query: 588 AEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEH----WPKGIAVNGF 643
I F+ +YP D R G D+I +F+ F +A + W + +
Sbjct: 459 PRIALTHFGLFDKYYPEDLRGQGHDII----SFWAFTTIARSKIHDDRIPWFRIMISGNV 514
Query: 644 GTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAE------HDSDFDWRRKEVGKL 697
+ G+KMSKSKGN+++ I++ GAD +R + ++++ D DF R+ V K+
Sbjct: 515 YDMYGEKMSKSKGNIVDIYSMIDKYGADALRFWASTVSQGDDIRIKDQDFTRGRRTVIKM 574
Query: 698 RRQLERFYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEF---RTRTAVQ 754
++ +++ + E+V+ +++W+L ++ +E T ++ + + RTA+
Sbjct: 575 -YNAKKLIDILKGDRKIRLFEDVK-HPVNRWILTEDSRIMETITTHMDNYEVSKARTALD 632
Query: 755 WAFYSIMND-----LRWYMRRTEGRD-----DEAKRFVLRKLADIWVRLMAPFTPHICEE 804
F+++ D ++ +++ DE + + D+ + AP P I EE
Sbjct: 633 TFFWNVFCDNYLEMIKPIIQKASAAGDYDTVDETVYTASKVMLDV-AKAYAPIMPFIAEE 691
Query: 805 LWEKL---GGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRA 861
+++ + G + + + WP+ + + EV +I S+I+ I+ AK+ R
Sbjct: 692 IYQTIDFPGRKISIHVDSWPDEKRRYSDANEEV--SYIVSVIDAIRSAKSAAKVSVGTRV 749
Query: 862 YIYTAPEWKWKVYEVVAEKREFKSAMAEL 890
+ + K +++ + R+ S M +
Sbjct: 750 KVASVKGRK----DLIEKYRDLLSGMLRI 774
>pir||SYBSVS valine--tRNA ligase (EC 6.1.1.9) - Bacillus stearothermophilus
Length = 880
Score = 119 bits (296), Expect = 1e-25
Identities = 92/332 (27%), Positives = 155/332 (45%), Gaps = 56/332 (16%)
Query: 2 PELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
P+ + RA+E + WL+ K FE P ++ F I + P ++G LH+GHA T+ D
Sbjct: 10 PKYDHRAVEAGRYEWWLKGKFFEAT--GDPNKRPFTIVIPPPNVTGKLHLGHAWDTTLQD 67
Query: 62 VIARFKRMQGYNVLFPMGWHITG-SPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
+I R KRMQGY+VL+ G G + + E+++ + + R+ + E W ++
Sbjct: 68 IITRMKRMQGYDVLWLPGMDHAGIATQAKVEEKLRQQGLSRYDLGREKFL---EETWKWK 124
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
+ + + + + G +D++RE +T L SK + F+ L KG I +G
Sbjct: 125 EE------YAGHIRSQWAKLGLGLDYTRERFT--LDEGLSKAVREVFVSLYRKGLIYRGE 176
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
+ + WDPV T L D +++ E L + +++ L +G ++ AT RPET+ G T
Sbjct: 177 YIINWDPVTKTALSDIEVVYKEVKGALYH--MRYPLADGSG--FIEVATTRPETMLGDTA 232
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
+ ++P+ + YK LIGK V+ P+
Sbjct: 233 VAVHPD---------------------DERYK-----------------HLIGKMVKLPI 254
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFD 332
G E+ I+ E+VD + +G V PAH P D
Sbjct: 255 VGREIPIIADEYVDMEFGSGAVKITPAHDPND 286
Score = 99.1 bits (243), Expect = 2e-19
Identities = 78/271 (28%), Positives = 136/271 (49%), Gaps = 20/271 (7%)
Query: 597 EFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGF-GTLEGQKMSKSK 655
+++ +YP D +G D+I ++ IF + + + K + ++G +G+KMSKS
Sbjct: 472 DYKRYYPTDVLVTGYDIIFFWVSRMIFQGLEFTGKRPF-KDVLIHGLVRDAQGRKMSKSL 530
Query: 656 GNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFA--- 712
GN ++ +D I++ GAD +R ++ + + D + ++V + + S+FA
Sbjct: 531 GNGVDPMDVIDQYGADALRYFLATGSSPGQDLRFSTEKVEATWNFANKIWN-ASRFALMN 589
Query: 713 ----EYEAKENVELKTI-DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RW 766
YE + KT+ D W+L RLN+ IE TK E++ + + I +DL W
Sbjct: 590 MGGMTYEELDLSGEKTVADHWILTRLNETIETVTKLAEKYEFGERGRTLYNFIWDDLCDW 649
Query: 767 YMRRTE----GRDDEAK---RFVLRKLADIWVRLMAPFTPHICEELWEKLGGEG-FVSLA 818
Y+ + G D+ AK R VL + D +RL+ PF P I EE+W+ L EG +++A
Sbjct: 650 YIEMAKLPLYGDDEAAKKTTRSVLAYVLDNTMRLLHPFMPFITEEIWQNLPHEGESITVA 709
Query: 819 KWPEPVDEWWNEEVEVEEDFIKSLIEDIKEI 849
WP+ E NEE E + +I ++ +
Sbjct: 710 PWPQVRPELSNEEAAEEMRMLVDIIRAVRNV 740
>sp|P11931|SYV_BACST VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|143797|gb|AAA22879.1| (M16318) valyl-tRNA synthetase
[Bacillus stearothermophilus]
Length = 880
Score = 119 bits (296), Expect = 1e-25
Identities = 92/332 (27%), Positives = 155/332 (45%), Gaps = 56/332 (16%)
Query: 2 PELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
P+ + RA+E + WL+ K FE P ++ F I + P ++G LH+GHA T+ D
Sbjct: 10 PKYDHRAVEAGRYEWWLKGKFFEAT--GDPNKRPFTIVIPPPNVTGKLHLGHAWDTTLQD 67
Query: 62 VIARFKRMQGYNVLFPMGWHITG-SPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFE 120
+I R KRMQGY+VL+ G G + + E+++ + + R+ + E W ++
Sbjct: 68 IITRMKRMQGYDVLWLPGMDHAGIATQAKVEEKLRQQGLSRYDLGREKFL---EETWKWK 124
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
+ + + + + G +D++RE +T L SK + F+ L KG I +G
Sbjct: 125 EE------YAGHIRSQWAKLGLGLDYTRERFT--LDEGLSKAVREVFVSLYRKGLIYRGE 176
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
+ + WDPV T L D +++ E L + +++ L +G ++ AT RPET+ G T
Sbjct: 177 YIINWDPVTKTALSDIEVVYKEVKGALYH--MRYPLADGSG--FIEVATTRPETMLGDTA 232
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
+ ++P+ + YK LIGK V+ P+
Sbjct: 233 VAVHPD---------------------DERYK-----------------HLIGKMVKLPI 254
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFD 332
G E+ I+ E+VD + +G V PAH P D
Sbjct: 255 VGREIPIIADEYVDMEFGSGAVKITPAHDPND 286
Score = 99.1 bits (243), Expect = 2e-19
Identities = 78/271 (28%), Positives = 136/271 (49%), Gaps = 20/271 (7%)
Query: 597 EFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGF-GTLEGQKMSKSK 655
+++ +YP D +G D+I ++ IF + + + K + ++G +G+KMSKS
Sbjct: 472 DYKRYYPTDVLVTGYDIIFFWVSRMIFQGLEFTGKRPF-KDVLIHGLVRDAQGRKMSKSL 530
Query: 656 GNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFA--- 712
GN ++ +D I++ GAD +R ++ + + D + ++V + + S+FA
Sbjct: 531 GNGVDPMDVIDQYGADALRYFLATGSSPGQDLRFSTEKVEATWNFANKIWN-ASRFALMN 589
Query: 713 ----EYEAKENVELKTI-DKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RW 766
YE + KT+ D W+L RLN+ IE TK E++ + + I +DL W
Sbjct: 590 MGGMTYEELDLSGEKTVADHWILTRLNETIETVTKLAEKYEFGERGRTLYNFIWDDLCDW 649
Query: 767 YMRRTE----GRDDEAK---RFVLRKLADIWVRLMAPFTPHICEELWEKLGGEG-FVSLA 818
Y+ + G D+ AK R VL + D +RL+ PF P I EE+W+ L EG +++A
Sbjct: 650 YIEMAKLPLYGDDEAAKKTTRSVLAYVLDNTMRLLHPFMPFITEEIWQNLPHEGESITVA 709
Query: 819 KWPEPVDEWWNEEVEVEEDFIKSLIEDIKEI 849
WP+ E NEE E + +I ++ +
Sbjct: 710 PWPQVRPELSNEEAAEEMRMLVDIIRAVRNV 740
>sp|P57519|SYL_BUCAI LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|10039108|dbj|BAB13142.1| (AP001119) leucyl-tRNA
synthetase [Buchnera sp. APS]
Length = 859
Score = 118 bits (294), Expect = 2e-25
Identities = 125/448 (27%), Positives = 191/448 (41%), Gaps = 82/448 (18%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
E + + IE Q+ W + K FE +K+ PK++K+Y PY SG LH+GH R YTI DV
Sbjct: 4 EYSPKKIENYVQEFWKKNKTFE--VKEDPKKEKYYCLPMLPYPSGKLHMGHVRNYTISDV 61
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDP 122
I+R++RM G NVL PMGW G P A R N DP + WT ++
Sbjct: 62 ISRYQRMLGKNVLQPMGWDAFGLPAEEAAIR-NNTDPFS---------------WTQKN- 104
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
+KY K + GFS DWSRE T+ P + + +W F KL EK + K
Sbjct: 105 ---IKYMKKQLQS----LGFSYDWSREI--TTCHPEYYHWEQWFFTKLYEKKLVYKKNSL 155
Query: 183 VRWDPVVGTPLGDHDLMEG------EDVPILEYVIIKFELKEGDETIY--LPAATLRPET 234
V W T L + +++G + I + +++ E++Y L T PE
Sbjct: 156 VNWCSYDKTVLANEQVIDGCCWRCQNKIRIKQIPQWFIKIRNYAESLYQDLKKLTHWPEN 215
Query: 235 VYGVTNMWI----------NPNATYVKAKVKRGGKE---ETWIISKEAAYKLSFQ-DREI 280
V + WI N T K KV + IS + +KLS ++
Sbjct: 216 VKNMQRNWIGRIKGFEITLNVFNTCQKLKVFTQRLDLLMGVTYISISSCHKLSINLSKKN 275
Query: 281 EVIEEF-KGEKLIGK---------------YVRNPVTGDEVIILPAEFVDPDNATGVVMS 324
E+I++F K + I + +V +P+T + I + + T V+S
Sbjct: 276 ELIKKFIKKYRYISQEEQYKVKYTGINTNLFVVHPITKKTIPIWISNATHIEYGTNAVLS 335
Query: 325 VPAHAPFDHVALEDLKRESEILVKYDI-DPRIVEEITYISLIKLEGYGEFPAVEEVQKLG 383
+P H D + ++ + +KY I +P E Y S + ++G L
Sbjct: 336 IPGHNENDW----NFAVKNNLKIKYVIFNPDHQEPKLYTSFLDIKG-----------TLF 380
Query: 384 IKSQKDREKLEQATKTIYKAEYHKGIFK 411
+ + L+ T+ I K Y K I K
Sbjct: 381 NSQEFNGLNLKDGTEKIKKILYKKKILK 408
>sp|P56457|SYL_HELPY LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437532|pir||C64713 leucine--tRNA ligase (EC
6.1.1.4) - Helicobacter pylori (strain 26695)
>gi|2314727|gb|AAD08585.1| (AE000652) leucyl-tRNA
synthetase (leuS) [Helicobacter pylori 26695]
Length = 806
Score = 118 bits (292), Expect = 4e-25
Identities = 105/377 (27%), Positives = 162/377 (42%), Gaps = 88/377 (23%)
Query: 4 LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
++F IE+KWQ+ W + K FEP KD K YI PY SG +H+GH R YTI D +
Sbjct: 1 MDFINIEKKWQEFWWKNKSFEP--KDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDAL 58
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
AR+ R+ YNVL PMG+ G P A IK+ W Y ++ + +E
Sbjct: 59 ARYYRLHHYNVLHPMGFDSFGMPAENAA--IKHGIHPKTWTYENIENMQKE--------- 107
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
F GFS +REF T+ P ++KF + F+ L EKG I + +
Sbjct: 108 -------------FEALGFSFSKNREFATSD--PDYTKFEQRFFIDLWEKGLIYRKKAML 152
Query: 184 RWDPVVGTPLGDHDLMEG-----------------------------EDVPILE-----Y 209
W P T L + +++G +D+ LE
Sbjct: 153 NWCPNDKTVLANEQVIDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLEALEDHWPSQ 212
Query: 210 VII------------KFELKEGDETI-------YLPAATLRPETVYGVTNMWINPNATYV 250
V+I +F K DE + + T R +T+YGVT + I P V
Sbjct: 213 VLIMQKNWIGKSSGLQFGFKIADECLKACNGIQEIEVFTTRADTIYGVTYIAIAPEHPLV 272
Query: 251 KAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPA 310
+ +K+ +E + +I +A + ++R +E K +G Y +P+T ++ + A
Sbjct: 273 EHAIKQVSQEVSKMI--KAILNTTQRERALE-----KKGAFLGIYAIHPLTKQKIPVWVA 325
Query: 311 EFVDPDNATGVVMSVPA 327
F + +G +M VPA
Sbjct: 326 NFALANYGSGALMGVPA 342
>sp|Q09828|SYLM_SCHPO PUTATIVE LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR
(LEUCINE--TRNA LIGASE) >gi|2130436|pir||S62486 probable
leucyl trna synthetase - fission yeast
(Schizosaccharomyces pombe) >gi|1022354|emb|CAA91210.1|
(Z56276) putative leucyl trna synthetase
[Schizosaccharomyces pombe]
Length = 874
Score = 118 bits (292), Expect = 4e-25
Identities = 109/374 (29%), Positives = 159/374 (42%), Gaps = 63/374 (16%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+F AI E W+ W F N K K K YI FPY SG LH+GH R YTI D+++
Sbjct: 33 DFLAIAENWKSYWKSHYPFVKNDKGKKK----YILSMFPYPSGLLHIGHVRVYTISDILS 88
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
R+ RM+GY V+ PMGW G P A I+N + W Y ++ K+ E+ T+ +N
Sbjct: 89 RYYRMKGYKVIHPMGWDAFGLPAENAA--IENGISASSWTYENIKKMKEQ---TYH--MN 141
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
I YF DW RE T + P + K+ ++ FL++ KG + V
Sbjct: 142 I--YF---------------DWDREISTCN--PDYYKWSQYLFLQMFHKGLAYQAEATVN 182
Query: 185 WDPVVGTPLGDHDL----MEGEDVPILEYVIIK---FELKEGDETIYLPAATLR--PETV 235
WDPV T L + + I+E ++ ++ + + + TL P+ V
Sbjct: 183 WDPVDCTVLANEQVDSHGRSWRSGAIVEKKNLRQWFLKISDYSDQLLDDLETLPKWPDKV 242
Query: 236 YGVTNMWINPNATYVKAKVKRGGKE---------ETWI------ISKEAAYKLSFQDREI 280
+ WI + + KE ET I +SK L ++
Sbjct: 243 KKMQRNWIGRTTGFEISFPLLNDKETLTVFTTKPETIIDVSFIALSKNHKLVLLESQKDP 302
Query: 281 EVIEEFKGEKLIGK------YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHV 334
+ E + E L+ K + +NPVTG + I A +V TG VM P H D
Sbjct: 303 SLAEHLRNESLLDKGYQLPCFAKNPVTGKALPIFYAPYVLDCYGTGAVMGAPIH---DRR 359
Query: 335 ALEDLKRESEILVK 348
E KR + I K
Sbjct: 360 DFEFAKRNNIIFSK 373
>pir||F82899 leucyl-tRNA synthetase UU371 [imported] - Ureaplasma urealyticum
>gi|6899353|gb|AAF30780.1|AE002134_4 (AE002134)
leucyl-tRNA synthetase [Ureaplasma urealyticum]
Length = 806
Score = 117 bits (291), Expect = 5e-25
Identities = 108/384 (28%), Positives = 167/384 (43%), Gaps = 91/384 (23%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKE-KKFYITVAFPYLSGH-LHVGHARTYTIPDV 62
N IE+KWQK WL+ K F+ D P KKFY+ FPY SG LHVGH + YT DV
Sbjct: 3 NHNKIEKKWQKYWLDNKTFK--FVDNPNNPKKFYVLDMFPYPSGKGLHVGHPKGYTATDV 60
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDP 122
I+RFKR+ GY+VL P+GW G P A N PHT +T ++
Sbjct: 61 ISRFKRLNGYDVLHPIGWDAFGLPAEQYALETNNH-PHT---------------FTQQN- 103
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
+K F K + GF D+ +E TT P F ++ +W F++L +
Sbjct: 104 ---IKIFRKQLQ----MIGFDFDYDKEVDTTD--PQFYQWTQWIFVQLYKHNLAEIQDID 154
Query: 183 VRWDPVVGTPLGDHDLM---EGEDV-----------PILEYVI----------------- 211
V W +GT L + +++ + E V P+ ++V+
Sbjct: 155 VNWCENLGTVLSNEEVVLNDKNERVSERGGHPVVRKPMKQWVLKIVDYADKLLDGLNEVE 214
Query: 212 --------------------IKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVK 251
++F++K D + L T R +T+YGV + + P +K
Sbjct: 215 FSESLKSLQRNWIGKSIGTSVQFKIK--DSLLTLDVFTTRIDTIYGVQYLVVAPEHPILK 272
Query: 252 AKVKRGGKEETWIISK--EAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILP 309
+ +++ ++ E K+S DR + + K G Y NP+ + + I
Sbjct: 273 SIT---SEQQINVVQSYIEQTKKISDLDR---IADTNKTGVFSGAYAINPINQEIIPIWV 326
Query: 310 AEFVDPDNATGVVMSVPAHAPFDH 333
+++V + ATG VM VPAH D+
Sbjct: 327 SDYVLMNFATGAVMGVPAHDERDY 350
Score = 76.5 bits (185), Expect = 1e-12
Identities = 62/237 (26%), Positives = 106/237 (44%), Gaps = 26/237 (10%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIF------REEHWPKGIAVNGFGTL 646
E K+ F W P+D G++ HL + F H ++ +E + K I
Sbjct: 517 EAKKRFAKWLPVDVYIGGQEHAVLHLLYSRFWHRFLYDIGVVPTKEPFYKVINQGMILGE 576
Query: 647 EGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE 706
+KMSKSKGNV+N D I +GAD +R+Y M + + W + +R+ L+R Y
Sbjct: 577 NNEKMSKSKGNVINPDDIIASHGADTLRIYEMFMGPLTASLPWNPDGLDAMRKWLDRVYR 636
Query: 707 LISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEE--FRTRTAVQWAFYSIMNDL 764
L +E E E +L +++ ++ + I+ TKA+ E F + F +++
Sbjct: 637 LYHNLSELEVVE--DLNKLNEEIIIAYHTLIKNYTKAINEQAFNIAISEMMVFVNVL--- 691
Query: 765 RWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
+ + +L D ++ L++ + PH+ EEL+ L V L K P
Sbjct: 692 ------------YKNKVINYELLDNFLILLSCYAPHLAEELY-SLNHSESVCLQKMP 735
>gb|AAB40843.1| (U82598) leucine tRNA synthetase [Escherichia coli]
Length = 907
Score = 116 bits (289), Expect = 9e-25
Identities = 107/372 (28%), Positives = 156/372 (41%), Gaps = 82/372 (22%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE K Q W E + FE +D+ KEK +Y PY SG LH+GH R YTI DVIAR++R
Sbjct: 57 IESKVQLHWDEKRTFEVT-EDESKEK-YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQR 114
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M G NVL P+GW G P G A +KN W Y D + +K
Sbjct: 115 MLGKNVLQPIGWDAFGLPAEGAA--VKNNTAPAPWTY---------------DNIAYMKN 157
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+K GF DWSRE T + P + ++ + F +L +KG + K V W P
Sbjct: 158 QLK-------MLGFGYDWSRELATCT--PEYYRWEQKFFTELYKKGLVYKKTSAVNWCPN 208
Query: 189 VGTPLGDHDLMEG-----------EDVP-----ILEY----------------------- 209
T L + +++G +++P I Y
Sbjct: 209 DQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQR 268
Query: 210 --------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEE 261
V I F + + D T L T RP+T G T + + + + +
Sbjct: 269 NWIGRSEGVEITFNVNDYDNT--LTVYTTRPDTFMGCTYLAVRAGHPLAQKAAENNPELA 326
Query: 262 TWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGV 321
+I + + E+ +E+ KG K V +P+TG+E+ + A FV + TG
Sbjct: 327 AFI---DECRNTKVAEAEMATMEK-KGVDTGFKAV-HPLTGEEIPVWAANFVLMEYGTGA 381
Query: 322 VMSVPAHAPFDH 333
VM+VP H D+
Sbjct: 382 VMAVPGHDQRDY 393
Score = 85.0 bits (207), Expect = 4e-15
Identities = 59/178 (33%), Positives = 89/178 (49%), Gaps = 14/178 (7%)
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKSK N ++ +E GAD VRL++M + D +W+ V R L+R ++L+
Sbjct: 666 KMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVY 725
Query: 710 QFAEYEAKENVELKTID------KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
E+ AK +V +D K L ++K I T + +T A +MN
Sbjct: 726 ---EHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNK 782
Query: 764 LRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
L T+G D A ++++ VR++ PFTPHIC LW++L GEG + A WP
Sbjct: 783 LA--KAPTDGEQDRA---LMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWP 835
>pir||E82590 leucyl-tRNA synthetase XF2176 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9107316|gb|AAF84975.1|AE004031_7
(AE004031) leucyl-tRNA synthetase [Xylella fastidiosa]
Length = 887
Score = 116 bits (288), Expect = 1e-24
Identities = 108/410 (26%), Positives = 162/410 (39%), Gaps = 118/410 (28%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE Q W FE N + + K+Y PY SG LH+GH R YTI DVI+R+KR
Sbjct: 21 IESTAQHYWDSTHAFEVN--EHSNKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKR 78
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M G+NVL PMGW G P A IKN+ W Y+++ ++ ++
Sbjct: 79 MTGHNVLQPMGWDAFGLPAENAA--IKNKVAPAQWTYKNIERMRTQLK------------ 124
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
G+++DWSREF T P + + F +L KG + V WDPV
Sbjct: 125 ----------SLGYAIDWSREFATCQ--PDYYVHEQHMFTRLMRKGLAYRRNALVNWDPV 172
Query: 189 VGTPLGDHDLMEG-----------EDVP-----ILEY----------------------- 209
T L + +++G ++P I +Y
Sbjct: 173 DQTVLANEQVIDGRGWRSGAPVEKREIPQWFLRITDYAQELLDGLNTLDDWPEPVKTMQR 232
Query: 210 --------VIIKFELKEGDETIY--LPAATLRPETVYGVTNMWI-------------NPN 246
+ I+FE+++ D L T RP+T+ GVT + I NP
Sbjct: 233 NWIGRSEGLEIQFEVRDADNNALEALRVFTTRPDTLLGVTFVSIAAEHPLALHAAKSNPA 292
Query: 247 ATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVI 306
+ ++K+GG E + ++E K G +P+T +++
Sbjct: 293 LAGLLTEMKQGGLSEAELKTQE------------------KRGMDTGLKAIHPITNEQLP 334
Query: 307 ILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIV 356
+ A FV TG VM+VP H +R+ E KY + R V
Sbjct: 335 VWVANFVLMAYGTGAVMAVPGHD----------QRDQEFANKYGLPIRQV 374
>sp|P07813|SYL_ECOLI LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7428464|pir||SYECL leucine--tRNA ligase (EC 6.1.1.4)
[validated] - Escherichia coli
>gi|1651269|dbj|BAA35289.1| (D90704) Leucine-tRNA ligase
(EC 6.1.1.4). [Escherichia coli]
>gi|1786861|gb|AAC73743.1| (AE000168) leucine tRNA
synthetase [Escherichia coli K12]
Length = 860
Score = 116 bits (287), Expect = 1e-24
Identities = 107/372 (28%), Positives = 156/372 (41%), Gaps = 82/372 (22%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE K Q W E + FE +D+ KEK +Y PY SG LH+GH R YTI DVIAR++R
Sbjct: 10 IESKVQLHWDEKRTFEVT-EDESKEK-YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQR 67
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M G NVL P+GW G P G A +KN W Y D + +K
Sbjct: 68 MLGKNVLQPIGWDAFGLPAEGAA--VKNNTAPAPWTY---------------DNIAYMKN 110
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+K GF DWSRE T + P + ++ + F +L +KG + K V W P
Sbjct: 111 QLK-------MLGFGYDWSRELATCT--PEYYRWEQKFFTELYKKGLVYKKTSAVNWCPN 161
Query: 189 VGTPLGDHDLMEG-----------EDVP-----ILEY----------------------- 209
T L + +++G +++P I Y
Sbjct: 162 DQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQR 221
Query: 210 --------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEE 261
V I F + + D T L T RP+T G T + + + + +
Sbjct: 222 NWIGRSEGVEITFNVNDYDNT--LTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELA 279
Query: 262 TWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGV 321
+I + + E+ +E+ KG K V +P+TG+E+ + A FV + TG
Sbjct: 280 AFI---DECRNTKVAEAEMATMEK-KGVDTGFKAV-HPLTGEEIPVWAANFVLMEYGTGA 334
Query: 322 VMSVPAHAPFDH 333
VM+VP H D+
Sbjct: 335 VMAVPGHDQRDY 346
Score = 85.0 bits (207), Expect = 4e-15
Identities = 59/178 (33%), Positives = 89/178 (49%), Gaps = 14/178 (7%)
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKSK N ++ +E GAD VRL++M + D +W+ V R L+R ++L+
Sbjct: 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVY 678
Query: 710 QFAEYEAKENVELKTID------KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
E+ AK +V +D K L ++K I T + +T A +MN
Sbjct: 679 ---EHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNK 735
Query: 764 LRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
L T+G D A ++++ VR++ PFTPHIC LW++L GEG + A WP
Sbjct: 736 LA--KAPTDGEQDRA---LMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWP 788
>sp|O26861|SYV_METTH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437639|pir||E69202 valine--tRNA ligase (EC 6.1.1.9)
MTH767 - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2621857|gb|AAB85270.1| (AE000855)
valyl-tRNA synthetase [Methanobacterium
thermoautotrophicum]
Length = 897
Score = 115 bits (285), Expect = 3e-24
Identities = 130/477 (27%), Positives = 216/477 (45%), Gaps = 49/477 (10%)
Query: 415 YDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKI-IHDQWFIDYGNSE 473
Y G + E KE I +++ +G + E +NV + + + I+I + QWF+
Sbjct: 328 YQGLTIAECKEKIVEDLENEGFL-LKKEPVRQNVGTCWRCKTPIEILVKKQWFV------ 380
Query: 474 WKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVI--ESLSD 531
A K+ P+ R A E + W+ R + + WD W I + +
Sbjct: 381 ---------AVKKLIPQVREAAEE--MKWVPGHMKTRLLNWTGSMDWD--WCISRQRIFA 427
Query: 532 STIYMAYYTISRHINRLREEGR-LDPEKLTPEFFDYIFLEEF-SEEREKELEKKTGI-PA 588
+ I + Y + ++ EE +DP + P EF EE + + I P
Sbjct: 428 TPIPVWYCSECGRVHVADEEMLPVDPTRDGPGITCECGSTEFIGEEDVLDTWMDSSISPL 487
Query: 589 EIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNG--FGTL 646
+ E + +P D R G D+I + I +A+ E+ + + I +NG FG
Sbjct: 488 SVAGWPDESYRELFPADLRPQGHDIIRTWAFYTILRCMALTGEKPFSE-IVINGMVFGE- 545
Query: 647 EGQKMSKSKGNVLNFIDAIEENGADVVRLYIM-SLAEHDSDFDWRRKEVGKLRRQLERFY 705
+G KMSKS+GNV+ + +E+ GAD +RL+ S+ D F W+ + G + L +F+
Sbjct: 546 DGHKMSKSRGNVIAPEEVLEDYGADALRLWAAGSVPGSDVPFAWKDVKYG--YKFLRKFW 603
Query: 706 ELISQFAEYEAKEN--VELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
+F EN VE + +D+W+L RL + T++L+++ AV I +D
Sbjct: 604 NAF-RFISIHLTENPEVEARPMDRWILSRLMNLVAEVTESLDDYNFAAAVNRVQTFIWHD 662
Query: 764 L-RWYMRRTEGR--DDE------AKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGF 814
Y+ + R DE A + LR + D +RL+AP PH EE+ + + GEG
Sbjct: 663 FCDEYIEAVKYRLYSDEDPESRMAAQNTLRMVLDTCLRLLAPVAPHFTEEVHQHV-GEGS 721
Query: 815 VSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAK--IESP-KRAYIYTAPE 868
+ L WPE + E + E+E D +I +I+ +K + +P K A IYT E
Sbjct: 722 IHLRGWPEHIPEIVDPEIERSGDLAVEIIGEIRRFKSSSKMPLNAPLKAATIYTDNE 778
Score = 113 bits (281), Expect = 7e-24
Identities = 88/314 (28%), Positives = 139/314 (44%), Gaps = 57/314 (18%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
E KWQK+W E ++ + ++ I PY +G +H+GH + D+IARFKRM
Sbjct: 35 EVKWQKKWQEEDIYR--FIGSGTKPRYIIDTPPPYPTGSIHMGHVLNWVYMDIIARFKRM 92
Query: 70 QGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYF 129
+G++VLFP GW G P +K + H I DV + L V + +
Sbjct: 93 RGFDVLFPQGWDCHGLP-----TEVKVEETHNI-KKSDVSREEFRRLC-----VELTQEN 141
Query: 130 MKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVV 189
++ KE R GFS DW+ EF T + P + + + FL++ G I +G H V W P
Sbjct: 142 IRMMKEQMQRLGFSQDWNHEFVT--MTPEYMRRTQLSFLRMYRDGLIYQGVHPVNWCPRC 199
Query: 190 GTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATY 249
T + ++ E+ L YV +F ++ DE ++ AT RPE + + ++P+
Sbjct: 200 ETAIAFAEVEYIENETNLNYV--RFPVEGADE--HITIATTRPELMAACVAVVVHPDDER 255
Query: 250 VKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILP 309
+ F+D+ IEV P+ G +V ++
Sbjct: 256 FR----------------------EFEDKLIEV----------------PLFGQKVKLIK 277
Query: 310 AEFVDPDNATGVVM 323
VDP+ TG VM
Sbjct: 278 DPEVDPEFGTGAVM 291
>emb|CAA29642.1| (X06331) leucyl-tRNA synthetase [Escherichia coli]
Length = 860
Score = 115 bits (284), Expect = 3e-24
Identities = 105/372 (28%), Positives = 154/372 (41%), Gaps = 82/372 (22%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE K Q W E + FE +D+ KEK +Y PY SG LH+GH R YTI DVIAR++
Sbjct: 10 IESKVQLHWDEKRTFEVT-EDESKEK-YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQH 67
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M G NVL P+GW G P G A +KN W Y D + +K
Sbjct: 68 MLGKNVLQPIGWDAFGLPAEGAA--VKNNTAPAPWTY---------------DNIAYMKN 110
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+K GF DWSRE T + P + ++ + F +L +KG + K V W P
Sbjct: 111 QLK-------MLGFGYDWSRELATCT--PEYYRWEQKFFTELYKKGLVYKKTSAVNWCPN 161
Query: 189 VGTPLGDHDLMEG-----------------------------EDVPILEY---------- 209
T L + +++G D+ L++
Sbjct: 162 DQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKINAYADELLNDLDKLDHWPDTVKTMQR 221
Query: 210 --------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEE 261
V I F + + D T L T RP+T G T + + + + +
Sbjct: 222 NWIGRSEGVEITFNVNDYDNT--LTVYTTRPDTFMGCTYLAVRAGHPLAQKAAENNPELA 279
Query: 262 TWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGV 321
+I + + E+ +E+ KG K V +P+TG+E+ + A FV + TG
Sbjct: 280 AFI---DECRNTKVAEAEMATMEK-KGVDTGFKAV-HPLTGEEIPVWAANFVLMEYGTGA 334
Query: 322 VMSVPAHAPFDH 333
VM+VP H D+
Sbjct: 335 VMAVPGHDQRDY 346
Score = 85.0 bits (207), Expect = 4e-15
Identities = 59/178 (33%), Positives = 89/178 (49%), Gaps = 14/178 (7%)
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELIS 709
KMSKSK N ++ +E GAD VRL++M + D +W+ V R L+R ++L+
Sbjct: 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVY 678
Query: 710 QFAEYEAKENVELKTID------KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
E+ AK +V +D K L ++K I T + +T A +MN
Sbjct: 679 ---EHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNK 735
Query: 764 LRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
L T+G D A ++++ VR++ PFTPHIC LW++L GEG + A WP
Sbjct: 736 LA--KAPTDGEQDRA---LMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWP 788
>sp|O51267|SYL_BORBU LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437538|pir||C70131 leucine--tRNA ligase (EC
6.1.1.4) leuS - Lyme disease spirochete
>gi|2688147|gb|AAB91495.1| (AE001135) leucyl-tRNA
synthetase (leuS) [Borrelia burgdorferi]
Length = 840
Score = 113 bits (281), Expect = 7e-24
Identities = 121/481 (25%), Positives = 193/481 (39%), Gaps = 103/481 (21%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVF----EPNIKDKPKEKKFYITVAFPYLSGH-LHVGHAR 55
M + F IE+KWQ+ W K + +P+I PKEK+ YI FPY S + LHVGH
Sbjct: 1 MSKYEFIKIEKKWQEFWDNNKTYKVEEDPSI---PKEKRLYILDMFPYPSANGLHVGHPE 57
Query: 56 TYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEI 115
YT D+ R+K + G++VL P+G+ G P A + P++
Sbjct: 58 GYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTGTH--------------PQK- 102
Query: 116 LWTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGY 175
+ E+ +N K +KA GF+ DW RE T + K+ +W FL+L +KG
Sbjct: 103 --STEENINKFKKQIKA-------LGFAYDWDREIRTHE--ENYYKWTQWIFLQLYKKGL 151
Query: 176 IVKGAHRVRWDPVVGTPLGDHDLMEGEDVP--------------------ILEY------ 209
V + P +GT L + ++++ D P I +Y
Sbjct: 152 AYVKEMPVWYCPELGTVLANEEIIQTSDGPKSERGSYSVEKKYLRQWVLKITKYAERLLD 211
Query: 210 ------------------------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINP 245
V I+FE++ + I T RP+T++G+T + I P
Sbjct: 212 DLEELEWPESVKEMQRNWIGKSTGVEIEFEIEGHSDKI--KVFTTRPDTIFGITYLVIAP 269
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEV 305
++ K K+ K K D +E+ K G Y +P+T +++
Sbjct: 270 ENKLIEKITKNNFKQNVLKYVKHEELK---SDLNRTSLEKDKSGVFTGSYAFHPITNEKI 326
Query: 306 IILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLI 365
I +V TG VM VPAH D + + + ++ I+E+ I
Sbjct: 327 PIWVGSYVLGTYGTGAVMGVPAHDERDFQFAKKYQLKILPVISKSGKNEILEKAFVDDGI 386
Query: 366 KLEGYGEF------PAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKP 419
+ EF ++V K K++K +EK+ YK IF Y G+P
Sbjct: 387 SINSPNEFNNLKNSEVKDKVIKWLTKNKKGKEKV------AYK--LRDWIFSRQRYWGEP 438
Query: 420 V 420
+
Sbjct: 439 I 439
>sp|O84211|SYL_CHLTR LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437540|pir||C71544 leucine--tRNA ligase (EC
6.1.1.4) - Chlamydia trachomatis (serotype D, strain
UW3/Cx) >gi|3328616|gb|AAC67801.1| (AE001294) Leucyl
tRNA Synthetase [Chlamydia trachomatis]
Length = 819
Score = 113 bits (280), Expect = 1e-23
Identities = 108/363 (29%), Positives = 149/363 (40%), Gaps = 74/363 (20%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIARFK 67
IEEKWQK W +VF+ +D+ K K +Y+ FPY SG LHVGH YT D++AR+K
Sbjct: 8 IEEKWQKFWENEQVFKAE-EDETKTK-YYVLDMFPYPSGAGLHVGHLIGYTATDIVARYK 65
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
R QG++VL PMGW G P A R T NI
Sbjct: 66 RAQGFSVLHPMGWDSFGLPAEQYAIRTGTHPRET-------------------TEKNIAN 106
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+ K+ GFS D SREF T+ P + K+ + FL L EKG V + P
Sbjct: 107 F-----KKQLTAMGFSYDESREFATSD--PEYYKWTQKLFLILYEKGLAYMADMAVNYCP 159
Query: 188 VVGTPLGDHDLMEGEDVP-------------ILEYVIIKFELKEGDETIYLPAA------ 228
+GT L + ++ G V +L +L EG + + P +
Sbjct: 160 ELGTVLSNEEIENGFSVDGGYPVERRMLRQWVLRITAFADQLLEGLDELDWPESVKQLQK 219
Query: 229 -----------------------TLRPETVYGVTNMWINPNATYVKAKVKRGGKEETWII 265
T RP+T+ GV+ + + P V K
Sbjct: 220 NWIGKSSGASVNFATEHGVIEVFTTRPDTLIGVSFLALAPEHPLVDLLTSDEQKAVVAQY 279
Query: 266 SKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSV 325
KE K S +DR E+ + K G Y ++PVT + I A++V +G VM V
Sbjct: 280 IKETQSK-SERDRISEM--KTKSGVFTGSYAKHPVTHKLIPIWIADYVLIGFGSGAVMGV 336
Query: 326 PAH 328
PAH
Sbjct: 337 PAH 339
Score = 76.5 bits (185), Expect = 1e-12
Identities = 75/272 (27%), Positives = 111/272 (40%), Gaps = 61/272 (22%)
Query: 595 KEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFR------------------------ 630
KE+ +YW P+D G + HL + F H +
Sbjct: 507 KEKEQYWMPVDLYIGGAEHAVLHLLYARFWHQVFYEAGIVSTPEPFKKLVNQGLVLATSY 566
Query: 631 -------------EEHWPKGIAVNGFGT-LEGQKMSKSKGNVLNFIDAIEENGADVVRLY 676
+E K +A +G + +KMSKSK N ++ I+E GAD VR+Y
Sbjct: 567 RIPGKGYIYPEIAKEENGKWVAPSGEELDVRQEKMSKSKLNGVDPQILIDEFGADAVRMY 626
Query: 677 IMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEYEAKENVELKTIDKWLLHRLNKA 736
M D + W + V RR L RFYE++S KE+ + + L H+L
Sbjct: 627 AMFSGPLDKNKLWSNQGVAGCRRFLNRFYEMVS---SDRVKEDNNFEGLS--LAHKL--- 678
Query: 737 IEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLA-DIWVRLMA 795
++ T A+E+ T + +F +ND K V K A ++ VR +A
Sbjct: 679 VQRVTDAIEKLSLNT-IPSSFMEFINDF-------------VKLAVYPKSAVEMAVRALA 724
Query: 796 PFTPHICEELWEKLGGEGFVSLAKWPEPVDEW 827
P PHI EELW LG V + WP + E+
Sbjct: 725 PIAPHISEELWVLLGNSPGVQKSGWPSVLPEY 756
>sp|O67411|SYV_AQUAE VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437657|pir||A70423 valine--tRNA ligase (EC 6.1.1.9)
- Aquifex aeolicus >gi|2983819|gb|AAC07375.1| (AE000739)
valyl-tRNA synthetase [Aquifex aeolicus]
Length = 1165
Score = 112 bits (278), Expect = 2e-23
Identities = 93/332 (28%), Positives = 148/332 (44%), Gaps = 41/332 (12%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
E N R IEEKW + W+E ++ +++ K KKF + + P ++G LH+GHA T+ DV
Sbjct: 5 EYNPREIEEKWSRYWIEKALY--HVEKPDKRKKFSVVIPPPNVTGSLHMGHALNATLQDV 62
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFED 121
I R++RM+G ++ G+ G + E+ + + + R+ + + +W +
Sbjct: 63 IVRWQRMRGRECVWVPGFDHAGIATQYVVEKQLAKEGKSRLELGREEFL---KKVWEW-- 117
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAH 181
V A + + G SVDW RE +T L FS+ + F L E+G I + +
Sbjct: 118 ----VPKSRNAIRTQLTKLGVSVDWKRERFT--LDEGFSRAVRKAFRTLFEEGLIYRAEY 171
Query: 182 RVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDET-IYLPAATLRPETVYGVTN 240
V W P T L D ++ E+ L Y+ + G +T ++ AT RPET+ G T
Sbjct: 172 IVNWCPNDRTALSDLEVEYEEEKGSLWYIKYPIVDENGKDTGEFITVATTRPETMLGDTA 231
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
+ +NPN K ++ K A L +R K +R
Sbjct: 232 VAVNPNDDRYK-----------HLVGKRARLPLVNWER---------------KDLRGNS 265
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFD 332
+ + I+ E V D TG V PAH P D
Sbjct: 266 VSNLIPIIADERVKMDFGTGAVKITPAHDPLD 297
Score = 90.1 bits (220), Expect = 1e-16
Identities = 99/399 (24%), Positives = 179/399 (44%), Gaps = 63/399 (15%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLE----- 647
E E+ + YP D +G D+I F + I H+ K I
Sbjct: 743 ESTEDLKNLYPTDLLVTGFDII------FFWVARMIMMGTHFMKDIPFYDVYVHALVRDK 796
Query: 648 -GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERF-- 704
G+KMSK+ GNV++ +D IE GAD +R + L D ++ + +
Sbjct: 797 YGRKMSKTIGNVIDPLDIIERYGADALRFTLAILTVQGRDIKLAEEKFEGYKHFANKIWN 856
Query: 705 ---YELISQFAEYEAK--ENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYS 759
Y L++ ++ A+ LK DKW++ +LN+ E KALE ++ A +
Sbjct: 857 AARYVLMNTPEDFIARIPYMAPLKPEDKWIITKLNETAEEVNKALENYQYSQAAHAIYEF 916
Query: 760 IMND-LRWYMRRTEGR-------DDEAKR-----------FVLRKLADIWVRLMAPFTPH 800
+D WY+ T+ R D+E ++ + L + + +R++ PF P+
Sbjct: 917 FWSDYCDWYIEFTKERIYKKAPEDNEEEKAKVENERTTALYTLHYVLEKALRILHPFMPY 976
Query: 801 ICEELWEKL-GGEG-FVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESP 858
I EELW KL EG +SLA++P+ ++ EE + + + +K +I I+ I +I+
Sbjct: 977 ITEELWHKLPNAEGESISLAEFPQKNEDEIYEEDKQKVERLKEIISAIRAIRSDLQIKPS 1036
Query: 859 K--RAYIYTAPEWKWKV----------------YEVVAEKREFKSAMAELMKDEEIRKHG 900
+ +A T E+ +V +E V+++ + + +A KD EI H
Sbjct: 1037 EKIKASFKTESEFSRRVIQEFKNHILNLAKLESFEEVSQRPQ--NTVATFSKDTEIYVHI 1094
Query: 901 K---EVAKLVQAIIKERAFDVKRIDEEKVLRESKDFLEK 936
+ ++ KL+Q+ K+R +K ++ +++FL+K
Sbjct: 1095 EGHVDLDKLIQSYEKKREKLLKELERVNKKLSNENFLKK 1133
>sp|P73505|SYI_SYNY3 ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437554|pir||S77211 isoleucine--tRNA ligase (EC
6.1.1.5) - Synechocystis sp. (strain PCC 6803)
>gi|1652625|dbj|BAA17545.1| (D90907) isoleucyl-tRNA
synthetase [Synechocystis sp.]
Length = 988
Score = 112 bits (277), Expect = 2e-23
Identities = 195/904 (21%), Positives = 357/904 (38%), Gaps = 148/904 (16%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
I++ WQ++ + A + + N KD F + PY +G LH+GHA + D+I ++K
Sbjct: 31 IQQYWQEKGIYADLADNNPKDL-----FVLHDGPPYANGALHMGHALNKVLKDIINKYKL 85
Query: 69 MQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
+QG+ V + GW G PI + + + +K+ + + +K +
Sbjct: 86 LQGHKVHYVPGWDCHGLPIELKVLQSLKSSERAELTPLTLRHKARD-------------- 131
Query: 128 YFMKAAKET---FIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
+ +KA +E F R G DW + + T L P + F + KGYI +G V
Sbjct: 132 FALKAQQEQAVGFQRYGIWGDWKKPYLT--LTPEYEAAQIGVFGAMALKGYIYRGLKPVH 189
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDE-----------TIYLPAATLRPE 233
W P T L + +L E + + + F + + E + + T P
Sbjct: 190 WSPSSRTALAEAEL-EYPEGHTSRSIYVSFPITQAGEKAAEILAPYIDDLAVAIWTTTPW 248
Query: 234 TVYGVTNMWINPNATYVKAKVKRGGKEETW-IISKEAAYKLSFQ-DREIEVIEEFKGEKL 291
T+ G + +NP TY + + ++ I++ + KLS ++ V +GE L
Sbjct: 249 TLPGNLAVALNPELTYAVVETESHIFHRSYLIVALDLVEKLSETFGVKLTVKVTLQGESL 308
Query: 292 IGKYVRNPVTGDEV--IILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKY 349
++P+ D V I++ ++V ++ TG+V + P H D+V + + IL
Sbjct: 309 ENTCYQHPLF-DRVSPIVIGGDYVTTESGTGLVHTAPGHGQEDYVVGQ--RYGLPILSPV 365
Query: 350 DIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGI 409
D + EE G+F + L A + I A
Sbjct: 366 DAAGNLTEEA-----------GKFAGL--------------NVLNDANEAIINA------ 394
Query: 410 FKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDY 469
+Q+ K L+ +E E + Y++ K + I +QWF
Sbjct: 395 ----------LQDQKVLLKEEAYEH---KYPYDWRTK--------KPTIFRATEQWFASV 433
Query: 470 GNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP--WDPEWVIE 527
++++A KA+ + P + ++ +R+ G P+P +D E
Sbjct: 434 --EGFRDQALKAIKEVTWIPTQGENRITPMVGDRSDWCISRQRAWGVPIPVFYDEETSEP 491
Query: 528 SLSDSTIYMAYYTISRHINR-LREEG-----RLDPEKLTPEFFDYIFLEEFSEEREKELE 581
L++ TI H+ + + E+G L E+L PE + E ++
Sbjct: 492 LLTEETI--------NHVQQIIAEKGSDAWWELTVEELLPEAYRNNGRTYRKGEDTMDVW 543
Query: 582 KKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVN 641
+G + K YP+D G D + VA+ + K + +
Sbjct: 544 FDSGSSWAAVANAKNR-PLKYPVDMYLEGSDQHRGWFQSSLLTSVAVNGIAPY-KTVLTH 601
Query: 642 GFGTLE-GQKMSKSKGNVLNFIDAIEEN---------GADVVRLYIMSLAEHDSDFDWRR 691
GF E G KMSKS GNV++ I GADV+RL++ S+ ++ +D +
Sbjct: 602 GFVLDEKGHKMSKSLGNVVDPYQIINGGKNQKQEPAYGADVLRLWVASV-DYANDVPIGQ 660
Query: 692 ---KEVGKLR---RQLERFY--ELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKA 743
K++ +R R RF L E +A +L +D+++LHR+ + T+A
Sbjct: 661 GILKQLVDIRNKIRNTARFLLGNLHDFNPETDAVAYEDLPELDRYMLHRMTEVFTEVTEA 720
Query: 744 LEEFRTRTAVQWA----------FYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRL 793
E F+ Q FY + R Y+ + + +L+ + +
Sbjct: 721 YESFQFFKFFQTVQNFCVVDLSNFYLDIAKDRLYISAPNAPRRRSCQTILQLALENLTKA 780
Query: 794 MAPFTPHICEELWEKLGGE---GFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEII 850
+AP H+ E++W+ L E V + W +W ++ + ++ L + I +++
Sbjct: 781 IAPVLCHLAEDIWQFLPYEKPTESVFQSGWVNLDAQWQQPQLAQKWVSLRQLRDGINQLL 840
Query: 851 EVAK 854
E A+
Sbjct: 841 EQAR 844
>gi|11499806 valyl-tRNA synthetase (valS) [Archaeoglobus fulgidus]
>gi|3122909|sp|O28059|SYV_ARCFU VALYL-TRNA SYNTHETASE
(VALINE--TRNA LIGASE) (VALRS) >gi|7437638|pir||H69527
valyl-tRNA synthetase (valS) homolog - Archaeoglobus
fulgidus >gi|2648303|gb|AAB89032.1| (AE000952)
valyl-tRNA synthetase (valS) [Archaeoglobus fulgidus]
Length = 863
Score = 112 bits (277), Expect = 2e-23
Identities = 96/318 (30%), Positives = 143/318 (44%), Gaps = 69/318 (21%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
+EEKW K W + + +KP + I PY +G H+GHA + I D IAR+KR
Sbjct: 12 VEEKWLKLWKDEMYYFDWNSEKPH---YIIDTPPPYPTGSFHIGHALNWCIIDFIARYKR 68
Query: 69 MQGYNVLFPMGWHITGSPI-VGIAER--IKNRDPHTIWIYRDVYKVPEEILWTFEDPVNI 125
M GY V+FP GW G P V + E+ IK D I RD ++ + F + NI
Sbjct: 69 MNGYEVMFPQGWDCHGLPTEVKVEEKYGIKKGD-----IPRDEFR---RLCVEFTEE-NI 119
Query: 126 VKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRW 185
K +ET R G+S+DWS+E+ T ++P + + F+++ KG I + H V +
Sbjct: 120 AK-----MRETARRMGYSIDWSKEYIT--MYPEYYSKTQLSFVRMYNKGLIYRDYHPVVF 172
Query: 186 DPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINP 245
P T + ++ + L Y IKF+ D+ I AT RPE + + ++P
Sbjct: 173 CPRCETTIALAEIEYRQGKTKLNY--IKFD----DDVI---IATTRPELIPACVAIAVHP 223
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEV 305
++ + + LIGK VR P T EV
Sbjct: 224 --------------------------------------DDERNKHLIGKKVRVPTTPYEV 245
Query: 306 IILPAEFVDPDNATGVVM 323
++ E VDP+ TGVVM
Sbjct: 246 EVIADEEVDPEFGTGVVM 263
Score = 105 bits (260), Expect = 2e-21
Identities = 146/573 (25%), Positives = 244/573 (42%), Gaps = 105/573 (18%)
Query: 411 KVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIH-DQWFIDY 469
K Y G + E +E I +++ ++G E + NV + + + ++II +QWF+
Sbjct: 296 KAGRYAGMTIPEAREAILEDLKKEGKLLKQVEI-DHNVGTCWRCKTPVEIIPAEQWFVKV 354
Query: 470 GNSEWKEKARKALARMKIYPETRRAQFEAII-----DWLDKKACARKVGLGTPLPWDPEW 524
KEK +A R+K PE ++ E+ + DW+ +R+ TP+P W
Sbjct: 355 E----KEKILEAAKRIKWVPEHMYSRLESWVQSMEWDWV----ISRQRIFATPIP---AW 403
Query: 525 VIESLSDSTIYMAYYTISRHINRLREEGR-LDPEKLTP-EFFDYIFLEEFSEEREK-ELE 581
++ + + +EE +DP P E EF E + +
Sbjct: 404 YCKNCGEVVV-------------AKEEWLPVDPTATQPPEPCPKCGSTEFRGETDVLDTW 450
Query: 582 KKTGIPAEII---HEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGI 638
+ I +I +KE YP R G D+I + I +A+ + W + I
Sbjct: 451 MDSSITPLMICGWPSLKE-----YPTHLRPQGHDIIRTWAFYTILRSLALEGQIPWYE-I 504
Query: 639 AVNG--FGTLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMS-LAEHDSDFDWRRKEVG 695
+NG FG +G+KMSKS GNV+ + +E+ G D +R + S + D F+W K+V
Sbjct: 505 VINGMVFGE-DGRKMSKSLGNVIVPEEVVEKYGVDALRQWAASGVIGDDIIFNW--KDVI 561
Query: 696 KLRRQLERFYEL----ISQFAEYEAKENVE--LKTIDKWLLHRLNKAIEGTTKALEEFRT 749
R ++F+ + + ++Y E + L+ D+W+L +LN+ + K ++E+R
Sbjct: 562 AASRFQQKFWSITRFTLMHISDYTPSEEDKKLLRDADRWILSKLNRLVGEVRKHMDEYRF 621
Query: 750 RTAVQ------WAFYSIMNDLRWYMRRTEGRDDEAKR---FVLRKLADIWVRLMAPFTPH 800
A++ W Y+ N L R +E KR FVL D+ RL+AP TP
Sbjct: 622 DEAIKAIRTFTWYEYAD-NYLEIVKNRLYSGSEEEKRAAKFVLSYALDVLTRLLAPITPF 680
Query: 801 ICEELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKR 860
+ EE W EG V L +P +E+ +E E E+IKEI+ + +
Sbjct: 681 MAEECWSHF-REGSVHLQSYPVVEEEFLDERAE-------KAGEEIKEIVAAVRKFKHDK 732
Query: 861 AYIYTAPEWKWKVY-------------------EVVAEKREFKSAMAELMKDEEI----- 896
AP K VY E+V E E + + EL I
Sbjct: 733 GLALNAPLKKLIVYSKLDGLDVRDIAGATNSEVEIVTEMPEVRERVKELKPKFAIIGPMF 792
Query: 897 RKHGKEVAKLVQAIIKERAFDVKRIDEEKVLRE 929
R+ K + K V ++ KE ++E++L+E
Sbjct: 793 REKAKTLIKAVGSLSKE--------EKERLLKE 817
>pir||G81698 leucyl-tRNA synthetase TC0481 [imported] - Chlamydia muridarum
(strain Nigg) >gi|7190521|gb|AAF39327.1| (AE002316)
leucyl-tRNA synthetase [Chlamydia muridarum]
Length = 819
Score = 111 bits (274), Expect = 5e-23
Identities = 103/367 (28%), Positives = 150/367 (40%), Gaps = 82/367 (22%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIARFK 67
IEEKWQK W E + F +D+ K K +Y+ FPY SG LHVGH YT D++AR+K
Sbjct: 8 IEEKWQKFWKEEQTFRAE-EDETKTK-YYVLDMFPYPSGAGLHVGHLIGYTATDIVARYK 65
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
R +G++VL PMGW G P A R T NI
Sbjct: 66 RAKGFSVLHPMGWDSFGLPAEQYAIRTGTHPRET-------------------TEKNIAN 106
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+ K+ GFS D SREF T+ P + K+ + FL L EKG V + P
Sbjct: 107 F-----KQQLTSMGFSYDESREFATSD--PEYYKWTQKLFLILYEKGLAYMADMAVNYCP 159
Query: 188 VVGTPLGDHDLMEGEDVP---------ILEYVI--------------------------- 211
+GT L + ++ G V + ++V+
Sbjct: 160 ELGTVLSNEEVENGFSVEGGYPVERRMLRQWVLRITAFADQLLGGLDELDWPESVKQLQR 219
Query: 212 ----------IKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEE 261
+ FE + G L T RP+T+ GV+ + + P V E+
Sbjct: 220 NWIGKSVGASVHFETEHG----VLEVFTTRPDTLIGVSFLVLAPEHPLVDLLT---SDEQ 272
Query: 262 TWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGV 321
I+++ S +R+ + K G Y ++PVT + + I A++V +G
Sbjct: 273 KTIVAQYVKETQSKSERDRISEMKTKSGVFTGAYAKHPVTQNPIPIWIADYVLMGYGSGA 332
Query: 322 VMSVPAH 328
VM VPAH
Sbjct: 333 VMGVPAH 339
Score = 71.0 bits (171), Expect = 6e-11
Identities = 64/220 (29%), Positives = 98/220 (44%), Gaps = 40/220 (18%)
Query: 649 QKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELI 708
+KMSKSK N ++ I+E GAD VR+Y M D + W + V RR L RFYE+
Sbjct: 599 EKMSKSKLNGVDPKVLIDEFGADAVRMYAMFSGPLDKNKLWSNQGVAGCRRFLNRFYEMA 658
Query: 709 --SQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW 766
S+ + + E + L +K ++ T +E+ T + +F +N+
Sbjct: 659 TSSRVKDEDIFEGMSL----------AHKLVQRVTDDIEKLSLNT-ITSSFMEFINEF-- 705
Query: 767 YMRRTEGRDDEAKRFVLRKLA-DIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVD 825
K V K A ++ VR +AP PHI EELW LG + A WP+ +
Sbjct: 706 -----------VKLPVYPKNAVEMAVRALAPIAPHISEELWVLLGNASGIEKAGWPKALP 754
Query: 826 EWW-----------NEEVEVEEDFIKSLIEDIKEIIEVAK 854
E+ N ++ D K IE+ E++ +AK
Sbjct: 755 EYLEGKIVTIVVQVNGKLRARLDISKDAIEE--EVVALAK 792
>sp|Q9ZCN6|SYV_RICPR VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437655|pir||B71675 valine--tRNA ligase (EC 6.1.1.9)
(valS) RP687 - Rickettsia prowazekii
>gi|3861224|emb|CAA15124.1| (AJ235272) VALYL-TRNA
SYNTHETASE (valS) [Rickettsia prowazekii]
Length = 814
Score = 110 bits (273), Expect = 6e-23
Identities = 74/244 (30%), Positives = 119/244 (48%), Gaps = 23/244 (9%)
Query: 5 NFRAIEEKWQKRWLEAKVF--EPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
NF E+KWQ W E +++ +PNI K + + + P +SG LH+GH +YT D
Sbjct: 9 NFTENEKKWQNIWQELQIYAYDPNIS---KAEIYIVDTPPPTVSGQLHIGHIYSYTQTDF 65
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDP 122
I RF+RM G N+ +P+G+ G P + E+ K + + RD + +
Sbjct: 66 IVRFQRMIGKNIFYPIGFDDNGLPTERLVEKQKQIKAYN--MERDEF---------IKIC 114
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
+ +VK + F + SVDWS E+ T S P K + FL L KG + +
Sbjct: 115 LEVVKNEEAKFRSLFKQIALSVDWSLEYQTIS--PLSRKISQMSFLDLLHKGEVYRANQP 172
Query: 183 VRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMW 242
+ WD V GT L D+ + + + + Y I F+ ++GD+ L AT RPE + ++
Sbjct: 173 ILWDTVDGTALAQADIEDKQKISSMNY--ITFKTEQGDQ---LTIATTRPELLPACVAVF 227
Query: 243 INPN 246
+P+
Sbjct: 228 YHPD 231
>sp|O83595|SYL_TREPA LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437534|pir||C71305 leucine--tRNA ligase (EC
6.1.1.4) - syphilis spirochete
>gi|3322882|gb|AAC65562.1| (AE001234) leucyl-tRNA
synthetase (leuS) [Treponema pallidum]
Length = 878
Score = 109 bits (270), Expect = 1e-22
Identities = 102/381 (26%), Positives = 151/381 (38%), Gaps = 91/381 (23%)
Query: 6 FRAIEEKWQKRWLEAKVFEPNIKDK-PKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVI 63
FRA+E+KWQ W + +VF + ++ P E++ Y+ FPY S LHVGH YT D+
Sbjct: 5 FRALEKKWQAYWRDKRVFCVSEDERFPPERRAYVLDMFPYPSAQGLHVGHPEGYTATDIY 64
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R+ RM GYNVL PMG+ G P A L T P
Sbjct: 65 CRYLRMGGYNVLHPMGFDAFGLPAENFA------------------------LKTGTHP- 99
Query: 124 NIVKYFMKAAKETFIRA----GFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKG 179
+ A +TF R GFS DW RE T P + ++ +W FLKL EKG +
Sbjct: 100 ---RVSTSANCDTFRRQIQSFGFSYDWEREISTAD--PEYYRWTQWLFLKLYEKGLAYEA 154
Query: 180 AHRVRWDPVVGTPLGDHDLMEG-----------------------------EDVPILEYV 210
+ W P T L + ++ + D+ L++
Sbjct: 155 TAPINWCPSCKTGLANEEVRDACCERCGAEVTRRGVRQWMVRITAYAERLLSDLDELDWP 214
Query: 211 IIKFELK----------EGDETIYLPAATLR---PETV----------YGVTNMWINPNA 247
+++ E D + PA ++ P+T+ +GVT + + P
Sbjct: 215 ESVKQMQRNWIGKSCGAEIDFPVDAPACSVHDKLPQTIRVYTTRADTLFGVTYLVLAPEH 274
Query: 248 TYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVII 307
V A + + AA K D E + + K G YVRNP+ + +
Sbjct: 275 EAVTALTTHAQRAAVQAYVQRAAKK---NDLERTDLAKEKTGVFTGAYVRNPINDMRIPV 331
Query: 308 LPAEFVDPDNATGVVMSVPAH 328
++V TG VM+VPAH
Sbjct: 332 WVGDYVLVSYGTGAVMAVPAH 352
>sp|P43834|SYV_HAEIN VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|1075441|pir||G64121 valine--tRNA ligase (EC 6.1.1.9)
- Haemophilus influenzae (strain Rd KW20)
>gi|1574225|gb|AAC23038.1| (U32819) valyl-tRNA
synthetase (valS) [Haemophilus influenzae Rd]
Length = 954
Score = 108 bits (266), Expect = 4e-22
Identities = 90/328 (27%), Positives = 143/328 (43%), Gaps = 55/328 (16%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N A+E+ +RW E+ F+P+ + + I + P ++G LH+GHA T+ D +
Sbjct: 12 NPSAVEQALYQRWEESGYFKPS--ENENAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLI 69
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIY-RDVYKVPEEILWTFEDP 122
RF RM+G+N L+ G G + ER I + T Y R+ + +W ++
Sbjct: 70 RFNRMEGHNTLWQTGTDHAGIATQMVVERKIAAEEGKTRHDYGREAF---INKIWDWK-- 124
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
Y + R G S+DW RE +T + S ++ F++L E+G I +G
Sbjct: 125 ----AYSGGTISQQMRRLGNSIDWERERFT--MDDGLSNAVKEVFVRLHEEGLIYRGKRL 178
Query: 183 VRWDPVVGTPLGDHDLMEGEDVPILEY--VIIKFELKEGDETIYLPAATLRPETVYGVTN 240
V WDP + T + D ++ E L + + + K D YL AT RPET+ G T
Sbjct: 179 VNWDPKLHTAISDLEVENKESKGSLWHFRYPLANDAKTADGKDYLVVATTRPETMLGDTA 238
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
+ ++P E+ + + LIGK V P+
Sbjct: 239 VAVHP--------------------------------------EDERYQSLIGKTVVLPL 260
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAH 328
E+ I+ E+VD + TGVV PAH
Sbjct: 261 ANREIPIIADEYVDREFGTGVVKITPAH 288
>sp|Q9Z930|SYL_CHLPN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|7437542|pir||C72113 leucine--tRNA ligase (EC
6.1.1.4) [similarity] - Chlamydophila pneumoniae
(strains CWL029 and AR39) >gi|4376420|gb|AAD18306.1|
(AE001602) Leucyl tRNA Synthetase [Chlamydophila
pneumoniae CWL029] >gi|7189530|gb|AAF38433.1| (AE002219)
leucyl-tRNA synthetase [Chlamydophila pneumoniae AR39]
>gi|8978526|dbj|BAA98363.1| (AP002545) leucyl tRNA
synthetase [Chlamydophila pneumoniae J138]
Length = 820
Score = 107 bits (264), Expect = 7e-22
Identities = 102/364 (28%), Positives = 155/364 (42%), Gaps = 75/364 (20%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVIARFK 67
IE+KWQ+ W E + F+ N +D+ K K +Y+ FPY SG LHVGH YT D++AR+K
Sbjct: 8 IEKKWQQFWKEHRSFQAN-EDEDKVK-YYVLDMFPYPSGAGLHVGHLIGYTATDIVARYK 65
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
R +G++VL PMGW G P A R T NI
Sbjct: 66 RARGFSVLHPMGWDSFGLPAEQYAIRTGTHPKVT-------------------TQKNIAN 106
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+ K+ GFS D REF T+ P + + + FL L ++G V + P
Sbjct: 107 F-----KKQLSAMGFSYDEGREFATSD--PDYYHWTQKLFLFLYDQGLAYMADMAVNYCP 159
Query: 188 VVGTPLGDHDLMEGEDVP-------------ILEYVIIKFELKEGDETIYLP-------- 226
+GT L + ++ G + IL+ +L EG + + P
Sbjct: 160 ELGTVLSNEEVENGFSIEGGYPVERKMLRQWILKITAYADKLLEGLDALDWPENVKQLQK 219
Query: 227 ----------------------AATLRPETVYGVTNMWINPNATYVKAKVKRGGKEETWI 264
A T R +T+ GV+ + I P + + V ++E
Sbjct: 220 NWIGKSEGALVTFHLTQEGSLEAFTTRLDTLLGVSFLVIAPEHPDLDSIVSEEQRDEVTA 279
Query: 265 ISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMS 324
+E+ K S +DR V + K G Y ++P+TG+ + + +++V TGVVM
Sbjct: 280 YVQESLRK-SERDRISSV--KTKTGVFTGNYAKHPITGNLLPVWISDYVVLGYGTGVVMG 336
Query: 325 VPAH 328
VPAH
Sbjct: 337 VPAH 340
Score = 78.4 bits (190), Expect = 4e-13
Identities = 78/266 (29%), Positives = 124/266 (46%), Gaps = 48/266 (18%)
Query: 649 QKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELI 708
+KMSKSK N ++ IEE GAD +R+Y M D + W + VG RR L RFY+L+
Sbjct: 600 EKMSKSKLNGVDPQVLIEEYGADALRMYAMFSGPLDKNKTWSNEGVGGCRRFLNRFYDLV 659
Query: 709 --SQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW 766
S+ + E ++ + L +K + T+ +E+ T + +F +ND
Sbjct: 660 TSSEVQDIEDRDGLVL----------AHKLVFRITEHIEKMSLNT-IPSSFMEFLNDF-- 706
Query: 767 YMRRTEGRDDEAKRFVLRKLA-DIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVD 825
+K V K A + VR++ P PHI EELW LG + A WP+ +D
Sbjct: 707 -----------SKLPVYSKRALSMAVRVLEPIAPHISEELWVILGNPPGIDQAAWPQ-ID 754
Query: 826 EWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKS 885
E + V F+ + ++ +EVAK E+PK EV++ R S
Sbjct: 755 E--SYLVAQTVTFVVQVNGKLRGRLEVAK-EAPKE--------------EVLSLSR---S 794
Query: 886 AMAELMKDEEIRKHGKEVAKLVQAII 911
+A+ +++ +IRK KLV ++
Sbjct: 795 VVAKYLENAQIRKEIYVPNKLVNFVL 820
>sp|P36420|SYV_LACCA VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|541449|pir||A49856 valine--tRNA ligase (EC 6.1.1.9)
- Lactobacillus casei >gi|409360|gb|AAA57558.1| (L08854)
valyl-tRNA synthetase [Lactobacillus casei]
Length = 901
Score = 107 bits (264), Expect = 7e-22
Identities = 93/345 (26%), Positives = 153/345 (43%), Gaps = 62/345 (17%)
Query: 2 PELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
P+ + +A+EE + WL+ VF+P+ DK K K + I + P ++G LH+GHA T+ D
Sbjct: 29 PKYDHKAVEEGRYQEWLDEDVFKPS-GDK-KAKPYSIVIPPPNVTGKLHMGHAWDTTLQD 86
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAE---RIKNRDPHTIWIYRDVYKVPEEILWT 118
++ R KR++G++ L+ G G E R + + + + V KV W
Sbjct: 87 IVIRQKRIEGFDTLWLPGMDHAGIATQAKVEAKLRKEGISRYDLGREKFVQKV-----WE 141
Query: 119 FEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVK 178
++D F K + + G S+D+SRE +T L ++ + F+ L +G I +
Sbjct: 142 WKDE------FAKTIHGQWAKMGLSLDYSRERFT--LDKGLNQAVRRVFVDLYNQGLIYR 193
Query: 179 GAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGV 238
G + V WDP T L D +++ +D +V F D + Y+ AT RPET+ G
Sbjct: 194 GEYIVNWDPQARTALSDIEVIHKDDKGAFYHVKYPF----ADGSGYIEIATTRPETMMGD 249
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRN 298
T + ++P + YK ++G +
Sbjct: 250 TAVAVHPG---------------------DERYK-----------------DMVGTELIL 271
Query: 299 PVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVA--LEDLKR 341
P+ ++ I+ +VDP+ TG V PAH P D DLKR
Sbjct: 272 PLANRKIPIIEDAYVDPEFGTGAVKITPAHDPNDFQVGNRHDLKR 316
>sp|Q05873|SYV_BACSU VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|541424|pir||S41420 valine--tRNA ligase (EC 6.1.1.9)
valS - Bacillus subtilis >gi|452309|emb|CAA54458.1|
(X77239) valyl-tRNA synthetase [Bacillus subtilis]
>gi|2635274|emb|CAB14769.1| (Z99118) valyl-tRNA
synthetase [Bacillus subtilis]
Length = 880
Score = 106 bits (263), Expect = 1e-21
Identities = 89/326 (27%), Positives = 150/326 (45%), Gaps = 56/326 (17%)
Query: 8 AIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
A+E+ WL+ K FE D+ KE + + + P ++G LH+GHA T+ D++ R K
Sbjct: 16 AVEKDRYDFWLKGKFFEAG-SDQTKEP-YSVVIPPPNVTGRLHLGHAWDTTLQDIVTRMK 73
Query: 68 RMQGYNVLFPMGWHITG-SPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIV 126
RMQGY+VL+ G G + + +++ + R+ + E W +++
Sbjct: 74 RMQGYDVLWLPGMDHAGIATQAKVEAKLREEGKSRYDLGREKFL---EETWKWKEE---- 126
Query: 127 KYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWD 186
+ + + + G +D+SRE +T L SK + F+KL EKG I +G + + WD
Sbjct: 127 --YADFIRSQWAKLGLGLDYSRERFT--LDEGLSKAVREVFVKLYEKGLIYRGEYIINWD 182
Query: 187 PVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPN 246
P T L D +++ +DV Y + + L +G +I + AT RPET+ G T + ++P
Sbjct: 183 PATKTALSDIEVIY-KDVQGAFY-HMSYPLADGSGSIEI--ATTRPETMLGDTAVAVHP- 237
Query: 247 ATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVI 306
E+ + + LIGK V P+ E+
Sbjct: 238 -------------------------------------EDERYKHLIGKTVILPIVNREIP 260
Query: 307 ILPAEFVDPDNATGVVMSVPAHAPFD 332
I+ ++VD + +G V PAH P D
Sbjct: 261 IVGDDYVDMEFGSGAVKITPAHDPND 286
Score = 99.1 bits (243), Expect = 2e-19
Identities = 82/333 (24%), Positives = 154/333 (45%), Gaps = 25/333 (7%)
Query: 596 EEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLE-GQKMSKS 654
E+F+ +YP D +G D+I ++ IF + E + K + ++G E G+KMSKS
Sbjct: 471 EDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERPF-KDVLIHGLIRDEQGRKMSKS 529
Query: 655 KGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFAEY 714
GN ++ +D I++ GAD +R ++ + + D + ++V + + S+FA
Sbjct: 530 LGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSYEKVESTWNFANKIWN-ASRFALM 588
Query: 715 --------EAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL-R 765
E + E DKW+L RLN+ IE T+ + + + + I +D
Sbjct: 589 NMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQLADRYEFGEVGRHLYNFIWDDFCD 648
Query: 766 WYMRRTE----GRDDEAK---RFVLRKLADIWVRLMAPFTPHICEELWEKLGGEG-FVSL 817
WY+ + G D+ AK R +L + D +RL+ PF P + EE+W+ L +G +++
Sbjct: 649 WYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMRLLHPFMPFLTEEIWQHLPHQGESITV 708
Query: 818 AKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVV 877
++WP V E + E + + LI ++ I K+ +Y + +
Sbjct: 709 SQWPAVVPEHTDTEAAADMKLLVELIRSVRNIRSEVNTPMSKQVELYIKTS-----TDEI 763
Query: 878 AEKREFKSAMAELMKDEEIRKHGKEVAKLVQAI 910
A + E + E + + K G ++ + +A+
Sbjct: 764 ASRLEANRSYVERFTNPSVLKIGTDIEAVDKAM 796
>sp|O13651|SYIC_SCHPO ISOLEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (ISOLEUCINE--TRNA LIGASE)
(ILERS) >gi|7492116|pir||T40751 isoleucyl-trna
synthetase, cytoplasmic - fission yeast
(Schizosaccharomyces pombe) >gi|2257546|dbj|BAA21439.1|
(AB004538) ISOLEUCYL-TRNA SYNTHETASE ,CYTOPLASMIC
[Schizosaccharomyces pombe] >gi|2950493|emb|CAA17821.1|
(AL022072) isoleucyl-trna synthetase, cytoplasmic
[Schizosaccharomyces pombe]
Length = 1064
Score = 106 bits (262), Expect = 1e-21
Identities = 187/854 (21%), Positives = 330/854 (37%), Gaps = 136/854 (15%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
EEK + W E F +K + P+ +G H GH TI D + R+ +
Sbjct: 9 EEKIVEFWREIDAFHTQLKLSQGRPTYTFFDGPPFATGRPHHGHLLASTIKDSVTRYACL 68
Query: 70 QGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYF 129
+GY+V GW G P+ ++ + + K E IV +
Sbjct: 69 KGYHVERRFGWDTHGLPVEHEIDKKLGITGSDDVMAMGIDKYNAECR-------KIVMTY 121
Query: 130 MKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVV 189
+ T R G +D+ ++ T L+P F + + W F +L KG + +G + +
Sbjct: 122 ASEWRATVERLGRWIDFDNDYKT--LYPSFMESVWWVFKELHTKGKVYRGYRVMPYSTAC 179
Query: 190 GTPLGDHDLMEG-EDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNAT 248
TPL + + + ++VP +++ F+ E +L A T P T+ + ++P+
Sbjct: 180 TTPLSNFEAQQNYKEVPD-PAIVVAFQSISDPEVSFL-AWTTTPWTLPSNLALAVHPDLQ 237
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGK-------YVRNPVT 301
Y+K K K+ + S + + E++E F+G+ L G+ Y ++
Sbjct: 238 YIKILDKDSNKKYILMESCLGILYKNPKKANFEILERFQGKALDGQKYEPLFPYFKSTFG 297
Query: 302 GDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITY 361
+ A++V+ + TG+V PA D+ D + I+ P V+E
Sbjct: 298 ERAFKLYSADYVEEGSGTGIVHQAPAFGEADY----DAAWAAGIIDADHQPPCPVDEQGL 353
Query: 362 ISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQ 421
++ + G++ V++ K I+S K L + H IF P+ +
Sbjct: 354 LTSEITDFAGQY--VKDADKEIIRSLKASGHLVK----------HSQIFHSYPFCWRSDT 401
Query: 422 EVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKA 481
+ + + EI E E NV+S V + I D+ F + W + AR
Sbjct: 402 PLIYRAVPSWFVR-VKEITNEMVE-NVMS---THWVPQNIRDKRF-----ANWLKNAR-- 449
Query: 482 LARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP-W---DPEWVI--------ESL 529
DW +R GTP+P W D E V+ E L
Sbjct: 450 -------------------DW----NISRNRYWGTPIPLWVSDDYEEVVCIGSIKELEEL 486
Query: 530 SD-STIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIF--------LEEFSEEREKEL 580
S S I + HI ++G+ +++ E FD F + ER +E
Sbjct: 487 SGVSNITDIHRDSIDHITIPSKKGKGTLHRVS-EVFDCWFESGSMPYASRHYPFERIEEF 545
Query: 581 EKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAV 640
K G PA+ I E ++ W+ T + + + + K + V
Sbjct: 546 --KHGFPADFISEGVDQTRGWF---------------YTLTVLGTLLFDKAPY--KNVIV 586
Query: 641 NGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDF-----DWRRKEV 694
+G E G+KMSK N IE+ G+D +RLY+++ ++ D R+ V
Sbjct: 587 SGLVMAEDGKKMSKRLKNYPEPNLIIEKYGSDALRLYLINSPVVRAEILKFKEDGVREVV 646
Query: 695 GKL-----------RRQLERFYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKA 743
++ Q + ++ + ++ + +D+W+L R I +
Sbjct: 647 TRVLIPWWNSYKFFEAQAALYKKVTGKDFVFDDAATLSSNVMDRWILARCQSLIGFVDEE 706
Query: 744 LEEFRTRTAVQWAFYSIMNDLRWYM----RRTEGRDDEAKRF----VLRKLADIWVRLMA 795
++++R T V I WY+ RR +G D E + VL ++ VR+M
Sbjct: 707 MKQYRLYTVVPQLLGLIEEMTNWYIRFNRRRLKGEDGEIETINALNVLFEVLFTLVRIMG 766
Query: 796 PFTPHICEELWEKL 809
PFTP I E +++ L
Sbjct: 767 PFTPFITENIYQHL 780
>pir||G81036 isoleucyl-tRNA synthetase NMB1833 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7227088|gb|AAF42168.1| (AE002533) isoleucyl-tRNA
synthetase [Neisseria meningitidis MC58]
Length = 929
Score = 105 bits (260), Expect = 2e-21
Identities = 206/962 (21%), Positives = 358/962 (36%), Gaps = 152/962 (15%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N E W K W E K ++ + KF + PY +G +H+GHA + D+I
Sbjct: 20 NLAKREPAWLKSWYEQKRYQKLREIAKGRPKFILHDGPPYANGDIHIGHAVNKILKDIII 79
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYK--VPEEILWTFEDP 122
R K G++ + GW G PI + E++ +D +R++ + E+I
Sbjct: 80 RSKTQAGFDAPYVPGWDCHGLPIEVMVEKLHGKDMPKAR-FRELCREYAAEQIA------ 132
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
K+ FIR G DW + T F + + ++ + GY+ +GA
Sbjct: 133 ---------RQKKDFIRLGVLGDWDHPYLTMD-FKTEADTVR-MLGEIYKSGYLYRGAKP 181
Query: 183 VRWDPVVGTPLGDHDLMEGEDV-PILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNM 241
V++ G+ L + ++ + + P ++ + + L + V T
Sbjct: 182 VQFCLDCGSSLAEAEVEYKDKISPAIDVAYLFKDTAALAAAFGLAGFEGKAFAVIWTTTP 241
Query: 242 WINPNATYVKA---------KVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLI 292
W P + V A +G ++++A + F D I ++ E G+KL
Sbjct: 242 WTLPASQAVSAGADVVYQLIDTPKGKLVLAKDLAEDALKRYGFSDG-IAILAETTGDKLE 300
Query: 293 GKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDID 352
++ +P ++ +L E V D TG+V + PAH LED + KY I+
Sbjct: 301 NLHMNHPFLERDIPMLNGEHVTTDAGTGLVHTAPAH------GLEDY----AVCNKYGIE 350
Query: 353 PRIVEEITYISLIKLEG--YGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIF 410
+ + EG GE P V ++ ++
Sbjct: 351 --------LYNPVNAEGRYIGETPRVAGMR----------------------------VW 374
Query: 411 KVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFI--D 468
+ P + ++E L+A +E A +I QWF+ D
Sbjct: 375 EANPVILQWLEETGNLLASSKIEHSYAHCWRH-----------KTPLIYRATGQWFVGMD 423
Query: 469 YGNSEWK---EKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWV 525
++ K +KA KA+ + +P RA+ EA+I+ +R+ GTP+
Sbjct: 424 KAGADGKTLRDKAIKAVDDTEFFPSWGRARLEAMIEGRPDWVVSRQRYWGTPM------- 476
Query: 526 IESLSDSTIYMAYYTISRHIN--RLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKK 583
T ++ T H N L E+ L E+ E + + E + E K
Sbjct: 477 -------TFFVHKETGELHPNSAELLEKVALKIEEKGIEAWFSLDKSELLSAEDCENYDK 529
Query: 584 TGIPAEIIHE--------MKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWP 635
++ + +K+ E +P D G D + A
Sbjct: 530 LSDTMDVWFDSGSTHYSVVKQREELEWPADLYLEGSDQHRGWFQSSMLTGCASSMGRAPY 589
Query: 636 KGIAVNGFGT-LEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMS------LAEHDSDFD 688
K + +GF EG+KMSKS GNV+ + E GAD++RL+ S LA
Sbjct: 590 KQLLTHGFVVDGEGKKMSKSIGNVVAPQEVYNEFGADILRLWAASTDYSGELAISKEILK 649
Query: 689 WRRKEVGKLRRQLERFYELISQFAEYE-AKENVELKTIDKW---LLHRLNKAIEGT--TK 742
+ ++R L + +S F E A + ++ ID++ L +L + + G +
Sbjct: 650 RVTESYRRIRNTLSFLFANLSDFNPIEDAVQQADMVEIDRYAVVLARQLQECLAGDYYPR 709
Query: 743 ALEEFRTRTAVQW------AFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAP 796
F + V + AFY + R Y + + + + L + V L+AP
Sbjct: 710 YAFHFAVKDIVSFCSEDLGAFYLDILKDRLYTTKADSHARRSAQTALYHITRSLVLLIAP 769
Query: 797 FTPHICEELWEKLGG--EGFVSLAKWPE--PVDEWWNEEVEVEEDFIKSLIEDIKEIIEV 852
EE W+ +GG E V W E ++E E+ + I+ E + IE
Sbjct: 770 ILCFTGEEAWDIIGGGEEDSVLFHTWHEFPTINEKTEAELVKKWTAIREAREAVTAAIEP 829
Query: 853 AKIESPKRAYI-----YTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHGKEVAKLV 907
+ + + + TAPE + E+ F A L+ E+ K G E+A
Sbjct: 830 LRADKTVGSSLQAEAEITAPEEMAGYLNALGEELRF----ALLVSKAEV-KVGSELAVAA 884
Query: 908 QA 909
+A
Sbjct: 885 KA 886
>sp|P15181|SYLM_NEUCR LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA
LIGASE) (LEURS) >gi|68520|pir||SYNCLM leucine--tRNA
ligase (EC 6.1.1.4) precursor, mitochondrial -
Neurospora crassa >gi|168830|gb|AAA33599.1| (M30472)
leucyl-tRNA synthetase [Neurospora crassa]
>gi|11595633|emb|CAC18253.1| (AL451018) leucine--tRNA
ligase precursor, mitochondrial [Neurospora crassa]
Length = 994
Score = 105 bits (259), Expect = 3e-21
Identities = 71/196 (36%), Positives = 95/196 (48%), Gaps = 29/196 (14%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
+L+ A+++KW+++W E+ + N +D EK Y+ FPY SGHLH+GH R YTI DV
Sbjct: 56 KLDLLALDQKWRQKWAESSREKGNKED---EKNKYVLPMFPYPSGHLHLGHLRVYTIADV 112
Query: 63 IARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDP 122
IARF+ +QG+ VL PMGW G P A + +P T WT
Sbjct: 113 IARFQTLQGHKVLLPMGWDAFGLPAENAAIE-RGINPAT---------------WT---K 153
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
NI K KE S DW+ E T P F K + FL L EKG +
Sbjct: 154 ANIAK-----MKEQLGHMNGSWDWNCELATCD--PDFYKHTQKIFLALHEKGLAYQAEAE 206
Query: 183 VRWDPVVGTPLGDHDL 198
V +DPV T L + +
Sbjct: 207 VNYDPVDKTVLANEQV 222
>pir||B81982 probable isoleucine--tRNA ligase (EC 6.1.1.5) NMA0622 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379357|emb|CAB83912.1| (AL162753) putative
isoleucyl-tRNA synthetase [Neisseria meningitidis Z2491]
Length = 929
Score = 105 bits (259), Expect = 3e-21
Identities = 211/958 (22%), Positives = 364/958 (37%), Gaps = 144/958 (15%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N E W K W E K ++ + KF + PY +G +H+GHA + D+I
Sbjct: 20 NLAKREPAWLKSWYEQKRYQKLREIAKGRPKFILHDGPPYANGDIHIGHAVNKILKDIII 79
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYK--VPEEILWTFEDP 122
R K G++ + GW G PI + E++ +D +R++ + E+I
Sbjct: 80 RSKTQAGFDAPYVPGWDCHGLPIEVMVEKLHGKDMPKAR-FRELCREYAAEQIA------ 132
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
K+ FIR G DW + T F + + ++ + GY+ +GA
Sbjct: 133 ---------RQKKDFIRLGVLGDWDNPYLTMD-FKTEADTVR-MLGEIYKSGYLYRGAKP 181
Query: 183 VRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIY-LPAATLRPETVYGVTNM 241
V++ G+ L + ++ + V V F+ T + L + V T
Sbjct: 182 VQFCLDCGSSLAEAEVEYKDKVSPAIDVGYPFKDTAALATAFGLAGIEGKAFAVIWTTTP 241
Query: 242 WINPNATYVKA---------KVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLI 292
W P + V A G ++++A + F D I ++ E G+KL
Sbjct: 242 WTLPASQAVSAGADVVYQLIDTPTGKLVLAKDLAEDALKRYGFSDG-IAILAETTGDKLE 300
Query: 293 GKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDID 352
++ +P ++ +L E V D TG+V + PAH LED + KY I+
Sbjct: 301 NLHMNHPFLERDIPMLNGEHVTTDAGTGLVHTAPAH------GLEDY----AVCNKYGIE 350
Query: 353 PRIVEEITYISLIKLEG--YGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIF 410
+ + EG GE P V + ++ +A I +
Sbjct: 351 --------LYNPVNAEGKYIGETPRVAGM------------RVWEANSVILQW------- 383
Query: 411 KVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFI--D 468
++E L+A +E A +I QWF+ D
Sbjct: 384 ---------LEETGNLLASSKIEHSYAHCWRH-----------KTPLIYRATGQWFVGMD 423
Query: 469 YGNSEWK---EKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWV 525
++ K +KA KA+ + +P RA+ EA+I+ +R+ GTP+ +
Sbjct: 424 KAGADGKTLRDKAIKAVDDTEFFPSWGRARLEAMIEGRPDWVVSRQRYWGTPMTFFVHKE 483
Query: 526 IESLSDSTIYMAYYTISRHINRLREEG-----RLDP-EKLTPEFFDYIFLEEFSEEREKE 579
L ++ + + + R+ E+G LD E L+ E D ++ S+ +
Sbjct: 484 TGELHPNSAEL----LEKVAQRIEEKGIEAWFSLDKGELLSAE--DCEHYDKLSDTMDVW 537
Query: 580 LEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIA 639
+ +G + + +EE + +P D G D + A K +
Sbjct: 538 FD--SGSTHYSVLKQREELD--WPADLYLEGSDQHRGWFQSSMLTGCASSMGRAPYKQLL 593
Query: 640 VNGFGT-LEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMS------LAEHDSDFDWRRK 692
+GF G+KMSKS GNV+ + E GAD++RL+ S LA +
Sbjct: 594 THGFVVDQNGRKMSKSIGNVVAPQEVYNEFGADILRLWAASTDYSGELAISKEILKRVTE 653
Query: 693 EVGKLRRQLERFYELISQFAEYE-AKENVELKTIDKW---LLHRLNKAIEGT--TKALEE 746
++R L + +S F E A + ++ ID++ L RL + + G +
Sbjct: 654 SYRRIRNTLSFLFANLSDFNPIEDAVQQADMVEIDRYALVLARRLQERVAGDFYPRYAFH 713
Query: 747 FRTRTAVQW------AFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPH 800
F + V + AFY + R Y + + R + + L + V L+AP
Sbjct: 714 FAVKEMVSFCSEDLGAFYLDILKDRLYTTKADSRARRSAQTALYHITRSLVLLIAPILCF 773
Query: 801 ICEELWEKLGG--EGFVSLAKWPE--PVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIE 856
EE W+ +GG E V W E ++E E+ + I+ E + IE + +
Sbjct: 774 TGEEAWDIIGGGAEDSVLFHTWHEFPTINEKAEAELVKKWTAIREAREAVTAAIEPLRAD 833
Query: 857 SPKRAYI-----YTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRKHGKEVAKLVQA 909
+ + TAPE + E+ F A L+ E+ K G E+A +A
Sbjct: 834 KTVGSSLQAEAEITAPEEMAGYLNALGEELRF----ALLVSKAEV-KVGSELAVAAKA 886
>pir||G83167 valyl-tRNA synthetase PA3834 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950009|gb|AAG07221.1|AE004800_10
(AE004800) valyl-tRNA synthetase [Pseudomonas
aeruginosa]
Length = 950
Score = 104 bits (256), Expect = 6e-21
Identities = 88/328 (26%), Positives = 140/328 (41%), Gaps = 64/328 (19%)
Query: 8 AIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
AIE W + W F P+ + +P + I + P ++G LH+GH I D + R++
Sbjct: 9 AIETSWYETWESNDYFAPSGEGQP----YTIMIPPPNVTGSLHMGHGFNNAIMDALIRYR 64
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
RMQG N L+ G G + ER + H + + + KV E W + N
Sbjct: 65 RMQGRNTLWQPGTDHAGIATQMVVERQLGAQGVSRHDLGREKFLEKVWE---WKEQSGGN 121
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
I + R G SVDWSRE +T + S+ ++ F++L E G I +G V
Sbjct: 122 ITRQIR--------RLGSSVDWSRERFT--MDDGLSEAVKEAFVRLHEDGLIYRGKRLVN 171
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETI----YLPAATLRPETVYGVTN 240
WD + T + D ++ ++ L + +++ L G +T YL AT RPET+ G
Sbjct: 172 WDTKLHTAISDLEVENHDEKGHLWH--LRYPLVNGAKTSEGLDYLVVATTRPETLLGDAA 229
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
+ ++P E+ + KLIG++ P+
Sbjct: 230 VAVHP--------------------------------------EDERYAKLIGQFAELPI 251
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAH 328
G + I+ E+VD + TG V PAH
Sbjct: 252 VGRHIPIIADEYVDREFGTGCVKITPAH 279
>emb|CAA29322.1| (X05891) valyl-tRNA synthetase [Escherichia coli]
Length = 951
Score = 104 bits (256), Expect = 6e-21
Identities = 90/329 (27%), Positives = 141/329 (42%), Gaps = 57/329 (17%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N + IE+ + W + F+PN + ++ F I + P ++G LH+GHA TI D +
Sbjct: 6 NPQDIEQPLYEHWEKQGYFKPNGDES--QESFCIMIPPPNVTGSLHMGHAFQQTIMDTMI 63
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R++RMQG N L+ +G G + ER I + T Y + + W E
Sbjct: 64 RYQRMQGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGG 123
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
I + R G SVDW RE +T + S ++ F++L ++ I +G V
Sbjct: 124 TITRQMR--------RLGNSVDWERERFT--MDEGLSNAVKEVFVRLYKEDLIYRGKRLV 173
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETI----YLPAATLRPETVYGVT 239
WDP + T + D ++ E + + I++ L +G +T YL AT RPET+ G T
Sbjct: 174 NWDPKLRTAISDLEVENRESKGSMWH--IRYPLADGAKTADGKDYLVVATTRPETLLGDT 231
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
+ +NP E+ + + LIGKYV P
Sbjct: 232 GVAVNP--------------------------------------EDPRYKDLIGKYVILP 253
Query: 300 VTGDEVIILPAEFVDPDNATGVVMSVPAH 328
+ + I+ E D + TG V PAH
Sbjct: 254 LVNRRIPIVGDEHADMEKGTGCVKITPAH 282
>gb|AAA24657.1| (J03497) valyl tRNA synthetase [Escherichia coli]
Length = 951
Score = 104 bits (256), Expect = 6e-21
Identities = 90/329 (27%), Positives = 141/329 (42%), Gaps = 57/329 (17%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N + IE+ + W + F+PN + ++ F I + P ++G LH+GHA TI D +
Sbjct: 6 NPQDIEQPLYEHWEKQGYFKPNGDES--QESFCIMIPPPNVTGSLHMGHAFQQTIMDTMI 63
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R++RMQG N L+ +G G + ER I + T Y + + W E
Sbjct: 64 RYQRMQGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTRHDYGAEAFIDKIWEWKAESGG 123
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
I + R G SVDW RE +T + S ++ F++L ++ I +G V
Sbjct: 124 TITRQMR--------RLGNSVDWERERFT--MDEGLSNAVKEVFVRLYKEDLIYRGKRLV 173
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETI----YLPAATLRPETVYGVT 239
WDP + T + D ++ E + + I++ L +G +T YL AT RPET+ G T
Sbjct: 174 NWDPKLRTAISDLEVENRESKGSMWH--IRYPLADGAKTADGKDYLVVATTRPETLLGDT 231
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
+ +NP E+ + + LIGKYV P
Sbjct: 232 GVAVNP--------------------------------------EDPRYKDLIGKYVILP 253
Query: 300 VTGDEVIILPAEFVDPDNATGVVMSVPAH 328
+ + I+ E D + TG V PAH
Sbjct: 254 LVNRRIPIVGDEHADMEKGTGCVKITPAH 282
>gb|AAA97155.1| (U14003) valyl-tRNA synthetase [Escherichia coli]
Length = 951
Score = 104 bits (256), Expect = 6e-21
Identities = 90/329 (27%), Positives = 141/329 (42%), Gaps = 57/329 (17%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N + IE+ + W + F+PN + ++ F I + P ++G LH+GHA TI D +
Sbjct: 6 NPQDIEQPLYEHWEKQGYFKPNGDES--QESFCIMIPPPNVTGSLHMGHAFQQTIMDTMI 63
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R++RMQG N L+ +G G + ER I + T Y + + W E
Sbjct: 64 RYQRMQGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGG 123
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
I + R G SVDW RE +T + S ++ F++L ++ I +G V
Sbjct: 124 TITRQMR--------RLGNSVDWERERFT--MDEGLSNAVKEVFVRLYKEDLIYRGKRLV 173
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETI----YLPAATLRPETVYGVT 239
WDP + T + D ++ E + + I++ L +G +T YL AT RPET+ G T
Sbjct: 174 NWDPKLRTAISDLEVENRESKGSMWH--IRYPLADGAKTADGKDYLVVATTRPETLLGDT 231
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
+ +NP E+ + + LIGKYV P
Sbjct: 232 GVAVNP--------------------------------------EDPRYKDLIGKYVILP 253
Query: 300 VTGDEVIILPAEFVDPDNATGVVMSVPAH 328
+ + I+ E D + TG V PAH
Sbjct: 254 LVNRRIPIVGDEHADMEKGTGCVKITPAH 282
>sp|P07118|SYV_ECOLI VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7428469|pir||SYECVT valine--tRNA ligase (EC 6.1.1.9)
- Escherichia coli (strain K-12)
>gi|1790708|gb|AAC77215.1| (AE000496) valine tRNA
synthetase [Escherichia coli K12]
Length = 951
Score = 104 bits (256), Expect = 6e-21
Identities = 90/329 (27%), Positives = 141/329 (42%), Gaps = 57/329 (17%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N + IE+ + W + F+PN + ++ F I + P ++G LH+GHA TI D +
Sbjct: 6 NPQDIEQPLYEHWEKQGYFKPNGDES--QESFCIMIPPPNVTGSLHMGHAFQQTIMDTMI 63
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R++RMQG N L+ +G G + ER I + T Y + + W E
Sbjct: 64 RYQRMQGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGG 123
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
I + R G SVDW RE +T + S ++ F++L ++ I +G V
Sbjct: 124 TITRQMR--------RLGNSVDWERERFT--MDEGLSNAVKEVFVRLYKEDLIYRGKRLV 173
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETI----YLPAATLRPETVYGVT 239
WDP + T + D ++ E + + I++ L +G +T YL AT RPET+ G T
Sbjct: 174 NWDPKLRTAISDLEVENRESKGSMWH--IRYPLADGAKTADGKDYLVVATTRPETLLGDT 231
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
+ +NP E+ + + LIGKYV P
Sbjct: 232 GVAVNP--------------------------------------EDPRYKDLIGKYVILP 253
Query: 300 VTGDEVIILPAEFVDPDNATGVVMSVPAH 328
+ + I+ E D + TG V PAH
Sbjct: 254 LVNRRIPIVGDEHADMEKGTGCVKITPAH 282
>sp|O84022|SYI_CHLTR ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437566|pir||F71565 probable isoleucine--tRNA ligase
(EC 6.1.1.5) - Chlamydia trachomatis (serotype D, strain
UW3/Cx) >gi|3328409|gb|AAC67609.1| (AE001277)
Isoleucyl-tRNA Synthetase [Chlamydia trachomatis]
Length = 1036
Score = 104 bits (256), Expect = 6e-21
Identities = 95/348 (27%), Positives = 158/348 (45%), Gaps = 30/348 (8%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
+++ A EEK W E +F+ + ++ F P+ +G H GH TI DV
Sbjct: 6 KISISAKEEKILSFWKEQDIFQKTLDNREGCPTFSFYDGPPFATGLPHYGHLLAGTIKDV 65
Query: 63 IARFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEE---ILWT 118
+ R+ M G+ V GW G P+ + + + +P I + V EE I++
Sbjct: 66 VCRYASMDGHYVPRRFGWDCHGVPVEYEVEKSLGLTEPGAIERF-GVANFNEECRKIVFR 124
Query: 119 FEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVK 178
+ D KYF+ R G VD+S + T L F + + W F L ++G + +
Sbjct: 125 YADE---WKYFVD-------RIGRWVDFSATWRTMDL--SFMESVWWVFRSLYDQGLVYE 172
Query: 179 GAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGV 238
G V + +GTPL + + + V++KF L+ D +L A T P T+
Sbjct: 173 GTKVVPFSTKLGTPLSNFEAGQNYKEVDDPSVVVKFALQ--DNQGFLLAWTTTPWTLVSN 230
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDRE-IEVIEEFKGEKLIGK--- 294
+ ++P TYV+ K K G E +I+ +E+ + F DRE E I + G+ L+G+
Sbjct: 231 MALAVHPELTYVRIKDKESGDE--YILGQESLPRW-FPDRESYEWIGQLSGKSLVGQSYE 287
Query: 295 ----YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALED 338
Y ++ + ILPA+F++ TG+V PA D A ++
Sbjct: 288 PLFPYFQDKKELEAFRILPADFIEESEGTGIVHMAPAFGEADFFACQE 335
Score = 83.1 bits (202), Expect = 1e-14
Identities = 86/321 (26%), Positives = 152/321 (46%), Gaps = 36/321 (11%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLE-GQKM 651
E EE E +P D+ G D A+F + + K + VNG E G KM
Sbjct: 532 ERAEETEACFPADFIAEGLDQTRGWFYTLTVIAAALFDQPAF-KNVIVNGIILAEDGNKM 590
Query: 652 SKSKGNVLNFIDAIEENGADVVRLYIM-SLAEHDSDFDWRRKEVGKLRRQLE-------R 703
SK N + ++ GAD +RLY++ S+ D + K V + +Q+
Sbjct: 591 SKRLNNYPSPKMIMDAYGADALRLYLLNSVVVKAEDLRFSDKGVESVLKQVLLPLSNALA 650
Query: 704 FYELISQFAEYEAKE--NVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIM 761
FY+ ++ ++ KE N+EL ID+W+L L + T +++ ++ AV F +
Sbjct: 651 FYKTYAELYGFDPKETDNIELAEIDRWILSSLYSLVGKTRESMSQYDLHAAVN-PFVDFI 709
Query: 762 NDL-RWYMRRTEGR----DDEAKR----FVLRKLADIWVRLMAPFTPHICEELWEKLGGE 812
DL WY+RR+ R +D A R L ++ ++ +++APF P I E+++++L GE
Sbjct: 710 EDLTNWYIRRSRRRFWDAEDSADRRAAFSTLYEVLVVFSKVIAPFIPFIAEDMYQQLRGE 769
Query: 813 ---GFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEW 869
V L +P V E ++E + ++DI+EI+ + S ++ + +
Sbjct: 770 TDPESVHLCDFPHVVLEKILPDLERK-------MQDIREIVALG--HSLRKEHKLKVRQP 820
Query: 870 KWKVYEVVAEKREFKSAMAEL 890
VY V +++R K A+A++
Sbjct: 821 LQNVYIVGSKER--KEALAQV 839
>pir||F81719 isoleucyl-tRNA synthetase TC0288 [imported] - Chlamydia muridarum
(strain Nigg) >gi|7190330|gb|AAF39156.1| (AE002296)
isoleucyl-tRNA synthetase [Chlamydia muridarum]
Length = 1036
Score = 104 bits (256), Expect = 6e-21
Identities = 93/345 (26%), Positives = 158/345 (44%), Gaps = 24/345 (6%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
+++F A EEK W E +F+ ++++ F P+ +G H GH TI DV
Sbjct: 6 KVSFPAKEEKVLTFWKEQNIFQKTLENRDGSPTFSFYDGPPFATGLPHYGHLLAGTIKDV 65
Query: 63 IARFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFED 121
+ R+ M G+ V GW G P+ + + + +P I + + EE
Sbjct: 66 VCRYATMDGHYVPRRFGWDCHGVPVEYEVEKSLGLTEPGAIDRF-GIANFNEECRKIVFR 124
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAH 181
V+ KYF+ R G VD+S + T L F + + W F L ++G + +G
Sbjct: 125 YVDEWKYFVD-------RIGRWVDFSATWKTMDL--SFMESVWWVFHSLYKQGLVYEGTK 175
Query: 182 RVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNM 241
V + +GTPL + + + V+ KF L++ D+ I L A T P T+ +
Sbjct: 176 VVPFSTKLGTPLSNFEAGQNYKEVDDPSVVAKFALQD-DQGILL-AWTTTPWTLVSNMAL 233
Query: 242 WINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDRE-IEVIEEFKGEKLIGK------ 294
++P TYV+ + K G+E +I+ +E+ + F DRE + I + GE L+G+
Sbjct: 234 AVHPGLTYVRIQDKESGEE--YILGQESLARW-FPDRESYKWIGQLSGESLVGRRYCPLF 290
Query: 295 -YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALED 338
Y ++ ++PA+F++ TGVV PA D A ++
Sbjct: 291 PYFQDQQDRGAFRVIPADFIEESEGTGVVHMAPAFGEADFFACQE 335
Score = 72.2 bits (174), Expect = 3e-11
Identities = 82/327 (25%), Positives = 145/327 (44%), Gaps = 34/327 (10%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLE-GQKM 651
E EE E +P D+ G D A+F + + K + VNG E G KM
Sbjct: 532 ERAEETEARFPADFIAEGLDQTRGWFYTLTVIAAALFDQPAF-KNVIVNGIVLAEDGNKM 590
Query: 652 SKSKGNVLNFIDAIEENGADVVRLYIM-SLAEHDSDFDWRRKEVGKLRRQLE-------R 703
SK N + ++ GAD +RLY++ S+ D + K V + +Q+
Sbjct: 591 SKRLNNYPSPKKIMDTYGADALRLYLLNSVVVKAEDLRFSDKGVEAVLKQVLLPLSNALA 650
Query: 704 FYELISQFAEYEAKE--NVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIM 761
FY+ ++ + E ++EL ID+W+L L + T + + ++ AV F +
Sbjct: 651 FYKTYAELYGFSPNETTDLELAEIDRWILSSLYSLVGKTRENMAQYDLHAAVS-PFIDFI 709
Query: 762 NDL-RWYMRRTEGR--------DDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGE 812
DL WY+RR+ R D A L ++ ++ +++APF P E+++++L E
Sbjct: 710 EDLTNWYIRRSRRRFWESEDSPDRRAAFATLYEVLMVFSKIIAPFIPFTAEDMYQQLRVE 769
Query: 813 ---GFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEW 869
V L +P V E ++ D K + +DI+EI+ + S ++ + +
Sbjct: 770 TDPESVHLCDFPHVVLE------KILPDLEKKM-QDIREIVALG--HSLRKEHKLKVRQP 820
Query: 870 KWKVYEVVAEKREFKSAMAELMKDEEI 896
+Y V A++R A + + EE+
Sbjct: 821 LQHMYIVGAKERMAALAQVDSLIGEEL 847
>pir||F81312 leucine--tRNA ligase (EC 6.1.1.4) Cj1091c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968525|emb|CAB73346.1| (AL139077) leucyl-tRNA
synthetase [Campylobacter jejuni]
Length = 809
Score = 103 bits (255), Expect = 8e-21
Identities = 107/391 (27%), Positives = 158/391 (40%), Gaps = 86/391 (21%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE+KWQK W E + FEP KD K YI FPY SG +H+GH R YTI D +AR+ R
Sbjct: 8 IEKKWQKIWDENEYFEP--KDDLNLPKKYILSMFPYPSGRIHMGHVRNYTIGDALARYYR 65
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
G+NVL P+G+ G P A IK++ W Y ++ + +E+
Sbjct: 66 KIGFNVLHPIGFDSFGMPAENAA--IKHKIHPKSWTYENIAYMKKEL------------- 110
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
GFS R T+ P ++KF + F+K+ EKG I V W
Sbjct: 111 ---------FSLGFSFSKKRMLATSD--PLYTKFEQEFFIKMFEKGLIYTKEANVNWCEQ 159
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIK------FELKEGDETIYLPAATLR---PETVYGVT 239
T L + + +G+ V+ K ++ E + L+ P V +
Sbjct: 160 DQTVLANEQVEDGKCWRCGHEVVQKKMPGYYVKITAYAEELLKDLEELKDKWPNQVLTMQ 219
Query: 240 NMWINPNA---------TYVKAKVKRGGKE-------------------ETWIISKEAAY 271
WI + K K K E E I+ +
Sbjct: 220 ENWIGKSEGLEFSLNLDEESKQKTKESSLEVFTTRADTIYGVSYIALAPEHKIVQNLLSQ 279
Query: 272 KLSFQD--REIEVI------EEFKGEK---LIGKYVRNPVTGDEVIILPAEFVDPDNATG 320
L QD +I+VI E EK +G Y +P++G+++ + A FV D +G
Sbjct: 280 NLLNQDVLNKIKVIQNQSPRERQSSEKEGYFLGIYAIHPLSGEKIPLWVANFVLADYGSG 339
Query: 321 VVMSVPAHAPFDHVALEDLKRESEILVKYDI 351
VM+VPAH +R+ E KY++
Sbjct: 340 AVMAVPAHD----------ERDFEFATKYNL 360
>sp|Q55522|SYV_SYNY3 VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437643|pir||S76034 hypothetical protein -
Synechocystis sp. (strain PCC 6803)
>gi|1001391|dbj|BAA10881.1| (D64006) valyl-tRNA
synthetase [Synechocystis sp.]
Length = 910
Score = 103 bits (255), Expect = 8e-21
Identities = 90/333 (27%), Positives = 138/333 (41%), Gaps = 54/333 (16%)
Query: 2 PELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
P+ E KWQ W E+ F+ + D+P E + + + P ++G LH+GHA ++ D
Sbjct: 7 PQYEPTVTEAKWQTAWEESHAFKAD-PDRPGEP-YCVVIPPPNVTGSLHMGHAFESSLID 64
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFED 121
+ R+ RM+G N L+ G + I ER + T + W E
Sbjct: 65 TLVRYHRMRGDNTLWLPGTDHASIAVQTILERQLKAEGKTRDDLGREKFLERAWQWKAES 124
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAH 181
IV R G SVDW+RE +T + S+ ++ F+KL E+G I +G +
Sbjct: 125 GSTIVNQLR--------RLGVSVDWTRERFT--MDEGLSQAVKTAFIKLYEEGLIYRGNY 174
Query: 182 RVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNM 241
V W P + + D ++ E L Y ++ L +G L AT RPET+ G T +
Sbjct: 175 LVNWCPASQSAVSDLEVENQEVDGHLWY--FRYPLTDGSGE--LVVATTRPETMLGDTGV 230
Query: 242 WINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVT 301
+NP+ A ++GK + P+
Sbjct: 231 AVNPHDERYAA--------------------------------------MVGKTITLPLV 252
Query: 302 GDEVIILPAEFVDPDNATGVVMSVPAHAPFDHV 334
E+ I+ E VDP+ TG V PAH P D V
Sbjct: 253 NREIPIVADELVDPEFGTGCVKVTPAHDPNDFV 285
>sp|O51773|SYI_BORBU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437557|pir||H70203 isoleucine--tRNA ligase (EC
6.1.1.5) ileS - Lyme disease spirochete
>gi|2688775|gb|AAC67179.1| (AE001181) isoleucyl-tRNA
synthetase (ileS) [Borrelia burgdorferi]
Length = 1042
Score = 103 bits (255), Expect = 8e-21
Identities = 97/358 (27%), Positives = 158/358 (44%), Gaps = 30/358 (8%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
NF IEEK K W + K+FE +IK + ++F P+ +G H GH TI D+I
Sbjct: 10 NFPKIEEKILKFWNDNKIFEKSIKQREGCEEFTFYDGPPFATGLPHFGHFVPNTIKDIIP 69
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTF-EDPV 123
R++ MQG V GW G P+ E+ Y++ + F ++
Sbjct: 70 RYQTMQGKYVKRNFGWDTHGLPVEYEVEKKLG--------ISGKYEIENYGIENFNKECR 121
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
IV + + K +R G VD+ + + T + F + + W F L EKG I + + +
Sbjct: 122 KIVLRYTEEWKNIILRLGRWVDFEKGYKTMDI--SFMESVWWVFKNLYEKGLIYESYYVL 179
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILE-YVIIKFELKEGDETIYLPAATLRPETVYGVTNMW 242
+ P + TPL + ++ GE + + + IKF++K+ +E YL T P T+ +N+
Sbjct: 180 PYSPKLATPLSNFEVNLGEYKEVNDPSLTIKFKIKDKNE--YLLVWTTTPWTL--PSNLG 235
Query: 243 INPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIG-------KY 295
I +K+ KEE I+ + + +IE+FKG KL G Y
Sbjct: 236 IAVGQEIEYSKIFDKTKEEILILGSKKLNSYYDDENSYTIIEKFKGSKLEGIEYEPIFNY 295
Query: 296 VRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDP 353
+ A++V D+ TG+V APF LK+ + + + IDP
Sbjct: 296 FLEQKDKGAFKVHTADYVTTDDGTGIVHI----APFGEEDYRILKKHTNVDI---IDP 346
>pir||T01656 leucyl-tRNA synthetase homolog K12CC - maize (fragment)
>gi|3264609|gb|AAC24575.1| (AF061510) putative
leucyl-tRNA synthetase [Zea mays]
Length = 100
Score = 103 bits (255), Expect = 8e-21
Identities = 44/80 (55%), Positives = 59/80 (73%)
Query: 463 DQWFIDYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDP 522
DQW+I YG +EWK+KA K L RM + R FE + WL++ AC+R GLGT +PWD
Sbjct: 7 DQWYITYGEAEWKQKAVKCLDRMNTFSTETRNGFEHTLGWLNQWACSRSFGLGTRIPWDE 66
Query: 523 EWVIESLSDSTIYMAYYTIS 542
++++ESLSDST+YMAYYT+S
Sbjct: 67 QFLVESLSDSTLYMAYYTVS 86
>gb|AAA34712.1| (M19992) isoleucyl-tRNA synthetase (EC 6.1.1.5) [Saccharomyces
cerevisiae]
Length = 1073
Score = 102 bits (252), Expect = 2e-20
Identities = 192/921 (20%), Positives = 354/921 (37%), Gaps = 177/921 (19%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNI---KDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
+F EEK W E F ++ KDKP+ F P+ +G H GH TI D
Sbjct: 9 SFPKEEEKVLSLWDEIDAFHTSLELTKDKPE---FSFFDGPPFATGTPHYGHILASTIKD 65
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWT 118
++ R+ M G++V GW G PI I ++ I +D DV+K E
Sbjct: 66 IVPRYATMTGHHVERRFGWDTHGVPIEHIIDKKLGITGKD--------DVFKYGLENY-- 115
Query: 119 FEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVK 178
+ +IV + ++T R G +D+ ++ T ++P F + W F +L EKG + +
Sbjct: 116 NNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKT--MYPSFMESTWWAFKQLHEKGQVYR 173
Query: 179 GAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGV 238
G + + + TPL + + + V I F + G E L A T P T+
Sbjct: 174 GFKVMPYSTGLTTPLSNFEAQQNYKDVNDPAVTIGFNV-IGQEKTQLVAWTTTPWTLPSN 232
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSF---QDREIEVIEEFKGEKLIG-- 293
++ +N + YVK + + + I E+ K + ++ + +++E+ KG L+G
Sbjct: 233 LSLCVNADFEYVKIYDE---TRDRYFILLESLIKTLYKKPKNEKYKIVEKIKGSDLVGLK 289
Query: 294 -----KYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVK 348
Y ++ ++V D+ TG+V + PA D+ A ++ ++ +
Sbjct: 290 YEPLFPYFAEQFHETAFRVISDDYVTSDSGTGIVHNAPAFGEEDNAAC----LKNGVISE 345
Query: 349 YDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKG 408
+ P ++++ G F KD
Sbjct: 346 DSVLPNAIDDL-----------GRF-------------TKD------------------- 362
Query: 409 IFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFID 468
VP ++G V++ +LI K + G + + + ++ WF+
Sbjct: 363 ---VPDFEGVYVKDADKLIIKYLTNTGNLLLASQIRHSYPFCWRSDTPLLYRSVPAWFVR 419
Query: 469 YGN--SEWKEKARKALARMKIYPETRRAQFEA-IIDWLDKKACARKVGLGTPLPWDPEWV 525
N + + K+ E R A + A DW +R GTP+P WV
Sbjct: 420 VKNIVPQMLDSVMKSHWVPNTIKEKRFANWIANARDW----NVSRNRYWGTPIPL---WV 472
Query: 526 IESLSD-----STIYMAYYTISRHINRLR-----------EEGRLDPEKLTPEFFDYIF- 568
+ + S + T R+I L ++G+ D +++ E FD F
Sbjct: 473 SDDFEEVVCVGSIKELEELTGVRNITDLHRDVIDKLTIPSKQGKGDLKRI-EEVFDCWFE 531
Query: 569 -------LEEFSEEREKELEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFF 621
+ + E ++ E++ +PA I E ++ W+ +
Sbjct: 532 SGSMPYASQHYPFENTEKFEER--VPANFISEGLDQTRGWF--------------YTLAV 575
Query: 622 IFNHVAIFREEHWPKGIAVNGFG-TLEGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSL 680
+ H +F + K + V+G +G+KMSKS N + + + GAD +RLY+++
Sbjct: 576 LGTH--LFGSVPYKKSVIVSGIVLAADGRKMSKSLKNYPDPSIVLNKYGADALRLYLINS 633
Query: 681 AEHDSDFDWRRKEVG-------KLRRQLERFYELISQFAEYEAKENVELKTID------- 726
++ + KE G L F L Q A + N++ + D
Sbjct: 634 PVLKAE-SLKFKEEGVKEVVSKVLLPWWNSFKFLDGQIALLKKMSNIDFQYDDSVKSDNV 692
Query: 727 --KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYMR--RTEGRDDEAKRFV 782
+ +L + ++ + + +++ T V I WY+R R + +
Sbjct: 693 MAEMILASMQSLVQVIHEEMGQYKLYTVVPKLLNFIDELTNWYIRFNRRRLKGENVVEDC 752
Query: 783 LRKLADI------WVRLMAPFTPHICEELW------------EKLGGEG-FVSLAKWPEP 823
L+ L + +VR MAPFTP + E ++ K G +G V +P
Sbjct: 753 LKALNSLFDALFTFVRAMAPFTPFLSESIYLRLKEYIPEAVLAKYGKDGRSVHFLSYPVV 812
Query: 824 VDEWWNEEVEVEEDFIKSLIE 844
E+++E +E ++S+I+
Sbjct: 813 KKEYFDEAIETAVSRMQSVID 833
>emb|CAB60428.1| (AL110500) contains similarity to Pfam domain: PF00133 (tRNA
synthetases class I (I, L, M and V)), Score=910.6,
E-value=1.5e-270, N=1~cDNA EST yk4g12.5 comes from this
gene~cDNA EST yk4g12.3 comes from this gene~cDNA EST
yk49e5.3 comes from this gene~c>
Length = 1050
Score = 102 bits (252), Expect = 2e-20
Identities = 203/939 (21%), Positives = 347/939 (36%), Gaps = 219/939 (23%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKE-----KKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
+E W W + F+P DK F + + P ++G+LHVGHA T+ D I
Sbjct: 88 VESGWYSWWEKEGFFKPEYIDKLNPGSNPADSFTVCIPPPNVTGNLHVGHALATTVEDTI 147
Query: 64 ARFKRMQGYNVLFPMGWHITG-SPIVGIAERIKNRDPHTIW-IYRDVYKVPEEILWTFED 121
RF RM G LF G G + V + +R+K T + RD + + +W +++
Sbjct: 148 TRFNRMHGKRTLFNPGCDHAGIATQVVVEKRLKRERGLTRHDLGRDRF---NQEVWHWKN 204
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAH 181
V Y + F + G SVDW R +T + P + + F+++ E G I +
Sbjct: 205 EKGDVIY------DQFRKLGASVDWDRAVFT--MDPKMCRAVTEAFIRMHESGTIYRSNR 256
Query: 182 RVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKE--GDETIYLPAATLRPETVYGVT 239
V W + + + D I+ + KE G I +P + E +GV
Sbjct: 257 LVNWSCALRSAISD----------------IEVDKKELTGSTLIAVPGYDKKIE--FGVL 298
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
N + K G +E ++S + ++ + + L+GK +P
Sbjct: 299 NSF----------AYKIQGSDEEIVVSTTRIETMLGDSGVAVHPDDQRYKHLVGKQCIHP 348
Query: 300 -VTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEE 358
+ + I FV+ + TG V PAH DH + E+ ++ ++
Sbjct: 349 FIPTRNLPIFADSFVEMEFGTGAVKITPAH---DH-------NDYEVGIRQNLP--FHNC 396
Query: 359 ITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGK 418
IT LI +G GEF + K A + +A KG+ Y GK
Sbjct: 397 ITDDGLIS-QGCGEFSGM---------------KRFDARTAVIEALKEKGL-----YRGK 435
Query: 419 PVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKA 478
++ ++ K + E I+ QW++ + K A
Sbjct: 436 --EDNPMVVPTCSRSKDVIE--------------------PILKPQWYVKCAHMAEKAVA 473
Query: 479 RKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAY 538
A ++I PE +A + ++ +R++ G +P AY
Sbjct: 474 AVANGDLQIIPEFHKATWNRWLESSRDWCISRQLWWGHRIP-----------------AY 516
Query: 539 YTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEE- 597
Y +GR P PE ++ E K +K AEI+ + E+
Sbjct: 517 YISF-------ADGREQP---LPEENYWVSARTEQEALAKAAQKFQVPEAEILLKWDEDV 566
Query: 598 FEYWYP--------LDWRCSGKD---------LIPNHLTFFIFNHVAIFREEHWP----- 635
+ W+ W + KD L H F + +F +
Sbjct: 567 LDTWFSSGMWPFAVFGWPDATKDMDLFFPGAVLETGHDILFFWVARMVFMAQELTGKLPF 626
Query: 636 KGIAVNG-FGTLEGQKMSKSKGNVLN---------------------------------- 660
K I ++ G+KMSKS GNV++
Sbjct: 627 KEILLHAMIRDAHGRKMSKSLGNVIDPLDVIRGISLNDLQAQLLGGNLDEKEIAVAKEGQ 686
Query: 661 ---FIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYEL-------ISQ 710
+ D I E G D +R ++S D + V R+ + +++ IS
Sbjct: 687 ARDYPDGIPECGVDALRFALLSYTSQGRDINLDVLRVHGYRKFCNKLWQVVRFALARISD 746
Query: 711 FAEYEAKENVELKT---IDKWLLHRLNKAIEGTTKALE--EFRTRTAVQWAF--YSIMND 763
E + + LK+ D W+L RL KA++ T +AL+ F T V + F Y +
Sbjct: 747 KPEQKPTFEINLKSATPTDLWILSRLAKAVKETNEALKAYNFTQATTVTYNFWLYDFCDV 806
Query: 764 LRWYMRRTEGRDDEAKR----FVLRKLADIWVRLMAPFTPHICEELWE---KLGGEGFVS 816
++ D+ R VL K D +RL++P P I EELW+ +L + S
Sbjct: 807 YVETIKPVLYGDNTTLRQVAISVLHKCIDTGLRLISPLMPFISEELWQRMPRLDDSDYTS 866
Query: 817 ----LAKWP--EPVDEWWNEEVEVEEDFIKSLIEDIKEI 849
+A++P + +++ NE++E +F + LI ++ +
Sbjct: 867 PSIIVAQYPLTQKYEKYQNEKLEAAFEFAQELIGKVRSL 905
>gb|AAF58412.1| (AE003819) CG4062 gene product [Drosophila melanogaster]
Length = 1049
Score = 100 bits (246), Expect = 1e-19
Identities = 184/933 (19%), Positives = 333/933 (34%), Gaps = 214/933 (22%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIK----DKPKEK-KFYITVAFPYLSGHLHVGHARTYTIPD 61
R +E +W W + F P D P KF + + P ++G LH+GHA T I D
Sbjct: 97 RYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIED 156
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDP----HTIWIYRDVYKVPEEILW 117
I R+ RM+G L+ G G + E++ RD H + + + ++ + W
Sbjct: 157 AITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWD---W 213
Query: 118 TFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
E I E G S DW+R +T + P + + F++L E+G I
Sbjct: 214 RREKGGRIY--------EQLKSLGSSYDWTRVAFT--MDPKLCRAVTEAFVRLHEEGSIY 263
Query: 178 KGAHRVRWDPVVGTPLGDHDL------------MEGEDVPILEYVIIKFELKEGDETIYL 225
+ + V W + + + D ++ + G + + V+IKF K +
Sbjct: 264 RSSRLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEI 323
Query: 226 PAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEE 285
AT R ET+ G T + ++P ++
Sbjct: 324 IVATTRIETMLGDTAVAVHP--------------------------------------QD 345
Query: 286 FKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEI 345
+ + L GK+V +P + + I+ EFVD TG V PAH P D
Sbjct: 346 DRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPND------------- 392
Query: 346 LVKYDIDPRIVEEITYISLIKLEG-----YGEFPAVEEVQKLGIKSQKDREKLEQATKTI 400
Y++ R + +I++ +G YGEF G+K + R+K+ + K +
Sbjct: 393 ---YEVGKRC--NLPFITIFNDDGYIIGDYGEF--------TGMKRFECRKKILEKLKAL 439
Query: 401 YKAEYHKGIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKI 460
+E + M+ + SR V +
Sbjct: 440 --------------------NLYRETLNNPMVVP-------------ICSR-SKDVVEPL 465
Query: 461 IHDQWFIDYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLP- 519
I QW++ + +KI PE + +D + +R++ G +P
Sbjct: 466 IKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPA 525
Query: 520 -----WDPEWVIESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSE 574
DP S D ++ + + + + E +D K+ + + + FS
Sbjct: 526 YHVSFTDPSLQTGSNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFS- 584
Query: 575 EREKELEKKTGI-PAEII--HEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFRE 631
+GI P + + ++ + +YP +G D++ + +F + +
Sbjct: 585 ---------SGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGK 635
Query: 632 EHWPKGIAVNGFGTLEGQKMSKSKGNVLNFIDAIE------------------------- 666
+ + G+KMSKS GNV++ +D I
Sbjct: 636 LPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAK 695
Query: 667 ------------ENGADVVRLYIMSLAEHDSDFDWRRKEVGKLR---------RQLERFY 705
E G+D +R + + D + V R + Y
Sbjct: 696 AGQKQDYPQGIPECGSDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLY 755
Query: 706 ELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALE--EFRTRTAVQWAFY----- 758
S+ + E + + +D W+L RL AIE E +F T+ +AF+
Sbjct: 756 FTGSEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLC 815
Query: 759 -SIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKL---GGEGF 814
+ L+ + A R L D +RL++PF P I EEL+++L
Sbjct: 816 DVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPS 875
Query: 815 VSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIK 847
+ +A +P W + ++E + +F++ I+
Sbjct: 876 ICVASYPSNT-SWRSTKIESDVEFVQKAARIIR 907
>pir||B81309 isoleucine--tRNA ligase (EC 6.1.1.5) Cj1061c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968497|emb|CAB73317.1| (AL139077) isoleucyl-tRNA
synthetase [Campylobacter jejuni]
Length = 917
Score = 100 bits (246), Expect = 1e-19
Identities = 170/793 (21%), Positives = 304/793 (37%), Gaps = 159/793 (20%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPK--EKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
N +E + K+W E +K+ K +K F + PY +GH+H+GHA + +
Sbjct: 19 NLAELEPQRFKKWFEQNYAYEKMKENRKNAKKSFTLHDGPPYANGHIHIGHALNKILKET 78
Query: 63 IARFKRMQGYNVLFPMGWHITGSPI-----VGIAERIKNRDPHTIWIYRDVYKVPEEILW 117
I + +G +V F GW G PI V + E+ K+ I R+ +
Sbjct: 79 IIKTHYFKGESVRFTPGWDCHGLPIEQQVEVKLGEKKKSLSKKEI---REFCR------- 128
Query: 118 TFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
F+ +E F G DW + + T F I ++ +KG +
Sbjct: 129 ------QHASEFVDIQREEFKDLGIIADWDKPYLTMKF--EFEAAIYRTLCEIAKKGLLC 180
Query: 178 KGAHRVRWDPVVGTPLGDHDL--MEGEDVPILEYVIIKFELKEGDETIYLPAA----TLR 231
+ + V W + L + ++ + ED I +V ++K ++ A+ T
Sbjct: 181 ERSKPVFWSWAAKSALAEAEVEYQDKEDYSI--FVAFDLDVKACEKLGVSKASAVIWTTT 238
Query: 232 PETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREI---EVIEEFKG 288
P T+ + +NPN YV K +I A K S ++ + E+ +E
Sbjct: 239 PWTLVANQAIALNPNENYVITK--------EGLIFASALLK-SMVEKGLTSGEIQKELNA 289
Query: 289 EKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVK 348
++ NP+ G + +++ E V D +G+V + P H D+ A LK E+L+
Sbjct: 290 KEFEKLEAINPLNGRKSVLIMGEHVLMDGGSGLVHTAPGHGEDDYYAC--LKYGIEVLMP 347
Query: 349 YDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKG 408
D + Y ++ +G +EE +G+ I+KA
Sbjct: 348 VD------DSGCYDETLRAKGLLPSHLLEEF--IGLH--------------IFKAN---- 381
Query: 409 IFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFI- 467
+++ EL+ ++++ Y F + ++ VI QWFI
Sbjct: 382 ------------EKILELLGEKLLHSSKFIHSYPFCWRT------HKPVIYRATKQWFIL 423
Query: 468 ----DYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPE 523
+E A++ L + YP++ + +G+ + P+
Sbjct: 424 MDEPKLQGKTLRECAKEQLLKTTFYPQSGVKR------------------IGSMVENRPD 465
Query: 524 WVIESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYI--FLEEFSEEREKELE 581
W I D +A++ ++ +E D E FD++ E+ + E E
Sbjct: 466 WCISRQRDWGTPIAFFR-----DKNTKEVIFD-----DELFDFVAAIFEKHGADAWWEFE 515
Query: 582 KKTGIP------AEIIHEMKEEFEYWYP--------------------LDWRCSGKDLIP 615
K IP AE + ++ + + W+ G D
Sbjct: 516 IKDLIPTNSKYKAENLEKVYDILDVWFDSGSTFNAVLNSGLYDAGEKRASMYLEGSDQHR 575
Query: 616 NHLTFFIFNHVAIFREEHWPKGIAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVR 674
+ AI E + I +GF T E GQKMSKSKGNV+ + G +++R
Sbjct: 576 GWFQSSLLVGTAI-NESAPYESILTHGFTTDEKGQKMSKSKGNVIASEYVAKTYGVEILR 634
Query: 675 LYIMSLAEHDSDF---DWRRKEVGKLRRQLERFYE-LISQFAEYEAKENVELKTIDKWLL 730
L+I+ L+++ SD D K+VG+ R++ L++ + + E E IDKW+L
Sbjct: 635 LWIL-LSDYSSDLKISDNILKQVGEQYRKIRNTIRFLLANTNDLKDLEVKEFSFIDKWIL 693
Query: 731 HRLNKAIEGTTKA 743
R K + + +A
Sbjct: 694 SRATKVFKASKEA 706
>sp|Q9ZHB3|SYI_STRPN ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|4009476|gb|AAC95446.1| (AF068901) isoleucine-tRNA
synthetase [Streptococcus pneumoniae]
Length = 930
Score = 99.5 bits (244), Expect = 2e-19
Identities = 83/331 (25%), Positives = 145/331 (43%), Gaps = 25/331 (7%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
E WQK W +AK+++ + + F + PY +G++HVGHA D+I R K M
Sbjct: 24 EPVWQKEWEDAKLYQRRQELNQGKPHFTLHDGPPYANGNIHVGHAMNKISKDIIVRSKSM 83
Query: 70 QGYNVLFPMGWHITGSPIVGIAER--IKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
G+ F GW G PI + + +K ++ + + K+ E + D
Sbjct: 84 SGFYAPFIPGWDTHGLPIEQVLSKQGVKRKEMDLV----EYLKLCREYALSQVD------ 133
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+E F R G S DW + T L P + F ++ KGYI +GA V W
Sbjct: 134 ----KQREDFKRLGVSGDWENPYVT--LTPDYEAAQIRVFGEMANKGYIYRGAKPVYWSW 187
Query: 188 VVGTPLGDHDLMEGEDVPILEYVIIKFELKEG--DETIYLPAATLRPETVYGVTNMWINP 245
+ L + ++ + V Y K + +G D Y+ T P T+ + +
Sbjct: 188 SSESALAEAEIEYHDLVSTSLYYANKVKDGKGVLDTDTYIVVWTTTPFTITASRGLTVGA 247
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLS--FQDREIEVIEEFKGEKLIGKYVRNP-VTG 302
+ YV V+ G+ ++++ E LS F +++V+E ++G++L +P T
Sbjct: 248 DIDYV--LVQPVGEARKFVVAAELLTSLSEKFGWADVQVLETYRGQELNHIVTEHPWDTA 305
Query: 303 DEVIILPAEFVDPDNATGVVMSVPAHAPFDH 333
E +++ + V D+ TG+V + P D+
Sbjct: 306 VEELVILGDHVTTDSGTGIVHTAPGFGEDDY 336
>gi|7661872 leucyl-tRNA synthetase, mitochondrial; KIAA0028 protein [Homo
sapiens] >gi|11449914|ref|XP_003255.1| leucyl-tRNA
synthetase, mitochondrial [Homo sapiens]
>gi|2501029|sp|Q15031|SYLM_HUMAN PROBABLE LEUCYL-TRNA
SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA
LIGASE) (LEURS) (KIAA0028) >gi|2104217|dbj|BAA04877.1|
(D21851) KIAA0028 [Homo sapiens]
Length = 903
Score = 98.7 bits (242), Expect = 3e-19
Identities = 65/197 (32%), Positives = 92/197 (45%), Gaps = 27/197 (13%)
Query: 4 LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
L R EKW + ++ + + + DK K K FY+ FPY SG LH+GH R YTI D I
Sbjct: 53 LQTRKDVEKWWHQRIKEQASKISEADKSKPK-FYVLSMFPYPSGKLHMGHVRVYTISDTI 111
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
ARF++M+G V+ PMGW G P A +N P + WT +
Sbjct: 112 ARFQKMRGMQVINPMGWDAFGLPAENAAVE-RNLHPQS---------------WTQSN-- 153
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
+K ++ R G W RE T+ P + K+ ++ F+KL E G + V
Sbjct: 154 ------IKHMRKQLDRLGLCFSWDREI--TTCLPDYYKWTQYLFIKLYEAGLAYQKEALV 205
Query: 184 RWDPVVGTPLGDHDLME 200
WDPV T L + + E
Sbjct: 206 NWDPVDQTVLANEQVDE 222
>pir||E82068 valyl-tRNA synthetase VC2503 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9657085|gb|AAF95645.1| (AE004320)
valyl-tRNA synthetase [Vibrio cholerae]
Length = 953
Score = 98.3 bits (241), Expect = 4e-19
Identities = 92/330 (27%), Positives = 142/330 (42%), Gaps = 59/330 (17%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N +IE+ K W E F+P+ D K+ + I + P ++G LH+GHA TI D +
Sbjct: 6 NPTSIEQDLYKTWEEQGYFKPH-GDTSKDA-YSIMIPPPNVTGSLHMGHAFQDTIMDTLI 63
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIY-RDVYKVPEEILWTFEDP 122
R +RM+G N L+ +G G + ER I + T Y RD + + + W E
Sbjct: 64 RCQRMKGKNTLWQVGTDHAGIATQMVVERKIAAEEGKTKHDYGRDAF-IDKIWEWKAESG 122
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
I K R G SVDW RE +T + F K ++ F++L + I +G
Sbjct: 123 GTITKQLR--------RLGASVDWDRERFT--MDDGFYKAVQEVFVRLYKDDLIYRGKRL 172
Query: 183 VRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETI----YLPAATLRPETVYGV 238
V WDP + T + D ++ E + + ++ L +G +T Y+ AT RPET+ G
Sbjct: 173 VNWDPKLHTAISDLEVENKETKGHMWH--FRYPLADGVKTADGKDYIVVATTRPETMLGD 230
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRN 298
T + +NP E+ + + LIGK +
Sbjct: 231 TGVAVNP--------------------------------------EDPRYKDLIGKEIIL 252
Query: 299 PVTGDEVIILPAEFVDPDNATGVVMSVPAH 328
P+ G + I+ E D + TG V PAH
Sbjct: 253 PIVGRRIPIVGDEHADMEKGTGCVKITPAH 282
>pir||E82001 valyl-tRNA synthetase NMA0094 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7378867|emb|CAB83410.1|
(AL162752) valyl-tRNA synthetase [Neisseria meningitidis
Z2491]
Length = 945
Score = 97.9 bits (240), Expect = 5e-19
Identities = 93/353 (26%), Positives = 154/353 (43%), Gaps = 65/353 (18%)
Query: 9 IEEKWQKRWLEAKVFEPNIK-DKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
IE K + W E F+P++ KP F I + P ++G LH+GHA TI D + R+
Sbjct: 10 IESKHYQNWEEQGYFQPDMDLTKPS---FSIQLPPPNVTGTLHMGHAFNQTIMDGLTRYY 66
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
RM+G N + G G + ER +N H + + + KV W +++
Sbjct: 67 RMKGCNTAWIPGTDHAGIATQIVVERQLAAQNVSRHDLGREKFLEKV-----WEWKEVSG 121
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
+ R G S DW+RE++T + ++ + F++L E+G I +G V
Sbjct: 122 ------GTITQQMRRVGCSADWTREYFT--MDDVRAETVTEVFVRLYEQGLIYRGKRLVN 173
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWIN 244
WDPV+GT + D ++ E+ + + I++ L + + AT RPET+ G + +N
Sbjct: 174 WDPVLGTAVSDLEVESVEEQGSMWH--IRYPLADNPAEAVI-VATTRPETLLGDVAVAVN 230
Query: 245 PNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDE 304
P E+ + LIGK + P+TG
Sbjct: 231 P--------------------------------------EDERYTHLIGKELILPLTGRT 252
Query: 305 VIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVK-YDIDPRIV 356
+ ++ E+V+ D TG V PAH D E KR LV +D++ +++
Sbjct: 253 IPVIADEYVEKDFGTGCVKITPAH---DFNDYEVGKRHDTRLVNVFDLEAKVL 302
>sp|P13503|SYLM_SACDO LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA
LIGASE) (LEURS) >gi|68519|pir||SYBYMX leucine--tRNA
ligase (EC 6.1.1.4) precursor, mitochondrial - yeast
(Saccharomyces sp.) >gi|4842|emb|CAA31343.1| (X12864)
leucyl tRNA synthetase (AA 1-894) [Saccharomyces
douglasii]
Length = 894
Score = 97.9 bits (240), Expect = 5e-19
Identities = 65/191 (34%), Positives = 90/191 (47%), Gaps = 30/191 (15%)
Query: 8 AIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
AI EKW+++ + + ++ K YI FPY SG LH+GH R Y I D + RF
Sbjct: 25 AIGEKWKQKTTRGPPKQGTLNNRSK----YILCQFPYPSGVLHIGHLRVYVISDSLNRFY 80
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
+ +GYNV+ PMGW G P A I R + +WT + NI K
Sbjct: 81 KQRGYNVIHPMGWDAFGLPAENAA------------IERGI----NPAIWTRD---NIAK 121
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
MK E+ + + DW RE T+ P + KF +W FLKL E G + + WDP
Sbjct: 122 --MKQQMESMLA---NFDWDRE--VTTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDP 174
Query: 188 VVGTPLGDHDL 198
V T L + +
Sbjct: 175 VDKTVLANEQV 185
>gb|AAF47943.1| (AE003482) CG7479 gene product [Drosophila melanogaster]
Length = 869
Score = 97.9 bits (240), Expect = 5e-19
Identities = 67/190 (35%), Positives = 88/190 (46%), Gaps = 31/190 (16%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
IE W+++ L F P K + K+Y+ FPY SG+LH+GH R YTI D +ARF+R
Sbjct: 42 IEAHWREQ-LSGGQFNP----KDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQR 96
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
M G NV PMGW G P AE N+ + E WT ++
Sbjct: 97 MCGKNVFQPMGWDSFGLP----AENAANQ------------RGVEPASWTEQN------- 133
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+ KE R G S DW+ E T S P + K+ + FL L G + V WDPV
Sbjct: 134 -IAQMKEQLKRLGCSFDWNHELSTCS--PKYYKWTQHLFLMLHRHGLAYQNEALVNWDPV 190
Query: 189 VGTPLGDHDL 198
T L D +
Sbjct: 191 DKTVLADEQV 200
>pir||T27887 hypothetical protein ZK524.3 - Caenorhabditis elegans
>gi|5596660|emb|CAA98144.2| (Z73912) predicted using
Genefinder~Similarity to Yeast leucyl-tRNA synthetase
(mitochonrial) (SW:SYLM_YEAST), contains similarity to
Pfam domain: PF00133 (tRNA synthetases class I (I, L, M
and V)), Score=118.5, E-value=4.1e-32, N=1~cDNA EST
yk132g5.3 >
Length = 835
Score = 97.5 bits (239), Expect = 6e-19
Identities = 62/187 (33%), Positives = 89/187 (47%), Gaps = 31/187 (16%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEK--KFYITVAFPYLSGHLHVGHARTYTIPDVIARF 66
+E+ W K +++ FE + K+KP K YI FPY SG LH+GH R YTI D AR+
Sbjct: 2 LEKHWSKSLVDS--FESS-KNKPSNLNGKKYILSMFPYPSGRLHIGHMRVYTISDATARY 58
Query: 67 KRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIV 126
R+ GY V+ P+GW G P A R K DP WT +
Sbjct: 59 YRLNGYEVIHPIGWDSFGLPAEN-AARDKGVDPRE---------------WTINN----- 97
Query: 127 KYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWD 186
+++ K+ ++ DW +E T P F ++ +W F KL E G + + + V WD
Sbjct: 98 ---IESMKQQLLKTKILFDWEKEISTCE--PEFFRWTQWIFCKLFEYGLVKRTSSEVNWD 152
Query: 187 PVVGTPL 193
P+ T L
Sbjct: 153 PIDKTVL 159
>pir||F81230 valyl-tRNA synthetase NMB0174 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225392|gb|AAF40631.1|
(AE002374) valyl-tRNA synthetase [Neisseria meningitidis
MC58]
Length = 945
Score = 97.1 bits (238), Expect = 8e-19
Identities = 87/332 (26%), Positives = 144/332 (43%), Gaps = 61/332 (18%)
Query: 1 MPELNFRAIEEKWQKRWLEAKVFEPNIK-DKPKEKKFYITVAFPYLSGHLHVGHARTYTI 59
+ + N IE K + W E F+P++ KP F I + P ++G LH+GHA TI
Sbjct: 2 LDKYNPAEIESKHYQNWEEQGYFQPDMDLTKPS---FSIQLPPPNVTGTLHMGHAFNQTI 58
Query: 60 PDVIARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEIL 116
D + R+ RM+G N + G G + ER +N H + + + KV
Sbjct: 59 MDGLTRYYRMKGCNTAWIPGTDHAGIATQIVVERQLAAQNVSRHDLGREKFLEKV----- 113
Query: 117 WTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYI 176
W +++ + R G S DW+RE++T + ++ + F++L E+G I
Sbjct: 114 WEWKEVSG------GTITQQMRRVGCSADWTREYFT--MDDVRAETVTEVFVRLYEQGLI 165
Query: 177 VKGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVY 236
+G V WDPV+GT + D ++ E+ + + I++ L + + AT RPET+
Sbjct: 166 YRGKRLVNWDPVLGTAVSDLEVESVEEQGSMWH--IRYPLADNPAEAVI-VATTRPETLL 222
Query: 237 GVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYV 296
G + +NP E+ + LIGK +
Sbjct: 223 GDVAVAVNP--------------------------------------EDERYTHLIGKEL 244
Query: 297 RNPVTGDEVIILPAEFVDPDNATGVVMSVPAH 328
P+TG + ++ E+V+ D TG V PAH
Sbjct: 245 ILPLTGRTIPVIADEYVEKDFGTGCVKITPAH 276
>gb|AAA35207.1| (J02719) valyl-tRNA synthetase [Saccharomyces cerevisiae]
Length = 1104
Score = 97.1 bits (238), Expect = 8e-19
Identities = 92/343 (26%), Positives = 140/343 (39%), Gaps = 67/343 (19%)
Query: 9 IEEKWQKRWLEAKVFEPNI----KDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+E W W++ VFEP K KP E F I P ++G LH+GHA T I D +
Sbjct: 153 VESSWYDWWIKTGVFEPEFTADGKVKP-EGVFCIPAPPPNVTGALHIGHALTIAIQDSLI 211
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R+ RM+G VLF G+ G + E+ I +D T Y V + W E
Sbjct: 212 RYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEE--- 268
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
+ K + G S DWSRE +T S P +K +E F++L ++G I + + V
Sbjct: 269 -----YHSRIKNQIQKLGASYDWSREAFTLS--PELTKSVEEAFVRLHDEGVIYRASRLV 321
Query: 184 RWDPVVGTPLGDHDL------------MEGEDVPILEYVIIKFELKEGDETIYLPAATLR 231
W + T + + ++ + G D + V+ F L AT R
Sbjct: 322 NWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYPVIGSDEKLIIATTR 381
Query: 232 PETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKL 291
PET++G T + ++P+ + YK L
Sbjct: 382 PETIFGDTAVAVHPD---------------------DDRYK-----------------HL 403
Query: 292 IGKYVRNPVTGDEV-IILPAEFVDPDNATGVVMSVPAHAPFDH 333
GK++++P ++ II E VD + TG V PAH D+
Sbjct: 404 HGKFIQHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDY 446
>gi|6321531 mitochondrial and cytoplasmic valyl-tRNA synthetase; Vas1p
[Saccharomyces cerevisiae]
>gi|1711655|sp|P07806|SYV_YEAST VALYL-TRNA SYNTHETASE,
MITOCHONDRIAL PRECURSOR (VALINE--TRNA LIGASE) (VALRS)
>gi|2144552|pir||SYBYVT valine--tRNA ligase (EC 6.1.1.9)
- yeast (Saccharomyces cerevisiae)
>gi|1323141|emb|CAA97097.1| (Z72879) ORF YGR094w
[Saccharomyces cerevisiae]
Length = 1104
Score = 97.1 bits (238), Expect = 8e-19
Identities = 92/343 (26%), Positives = 140/343 (39%), Gaps = 67/343 (19%)
Query: 9 IEEKWQKRWLEAKVFEPNI----KDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+E W W++ VFEP K KP E F I P ++G LH+GHA T I D +
Sbjct: 153 VESSWYDWWIKTGVFEPEFTADGKVKP-EGVFCIPAPPPNVTGALHIGHALTIAIQDSLI 211
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
R+ RM+G VLF G+ G + E+ I +D T Y V + W E
Sbjct: 212 RYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEE--- 268
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
+ K + G S DWSRE +T S P +K +E F++L ++G I + + V
Sbjct: 269 -----YHSRIKNQIQKLGASYDWSREAFTLS--PELTKSVEEAFVRLHDEGVIYRASRLV 321
Query: 184 RWDPVVGTPLGDHDL------------MEGEDVPILEYVIIKFELKEGDETIYLPAATLR 231
W + T + + ++ + G D + V+ F L AT R
Sbjct: 322 NWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYPVIGSDEKLIIATTR 381
Query: 232 PETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKL 291
PET++G T + ++P+ + YK L
Sbjct: 382 PETIFGDTAVAVHPD---------------------DDRYK-----------------HL 403
Query: 292 IGKYVRNPVTGDEV-IILPAEFVDPDNATGVVMSVPAHAPFDH 333
GK++++P ++ II E VD + TG V PAH D+
Sbjct: 404 HGKFIQHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDY 446
>pir||T39630 valine-tRNA ligase precursor, mitochondrial - fission yeast
(Schizosaccharomyces pombe) >gi|7493608|pir||T39665
valine-tRNA ligase precursor, mitochondrial - fission
yeast (Schizosaccharomyces pombe)
>gi|3738140|emb|CAA21241.1| (AL031852) valyl-trna
synthetase, mitochondrial [Schizosaccharomyces pombe]
>gi|3738176|emb|CAA21312.1| (AL031856) valyl-trna
synthetase, mitochondrial precursor [Schizosaccharomyces
pombe]
Length = 980
Score = 96.7 bits (237), Expect = 1e-18
Identities = 94/351 (26%), Positives = 148/351 (41%), Gaps = 75/351 (21%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKK---FYITVAFPYLSGHLHVGHARTYTIPD 61
N +A+E W W+++ FEP K KK F IT P ++G LH+GHA T I D
Sbjct: 98 NPKAVESAWYDWWVKSGFFEPEFGPDGKPKKEGVFVITSPPPNVTGALHIGHALTIAIQD 157
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAER----IKNRDPHTIWIYRDVYKVPEEILW 117
+AR+ RM G VLF G+ G + E+ + + H RD + +I+W
Sbjct: 158 SLARWNRMLGKTVLFLGGFDHAGLSTQSVVEKKLWYTQKKTRHD--YPRDKF---VDIVW 212
Query: 118 TFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
+++ + K R G S DW+RE +T + S+ + F++L E+ I
Sbjct: 213 EWKEE------YHNRIKNQMSRLGGSFDWTREAFT--MDENLSRAVVETFVRLHEENIIY 264
Query: 178 KGAHRVRWDPVVGTPLGDHDL------------MEGEDVPILEYVI--IKFELKEGDETI 223
+ V W + T L + ++ + G D P+ V+ I + ++ DE I
Sbjct: 265 RANRLVNWCTALQTTLSNLEVENVDVPGRTLLKVPGYDEPVEVGVLTSIAYAVEGSDERI 324
Query: 224 YLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVI 283
+ AT RPET+ G T + ++P ++ YK
Sbjct: 325 VI--ATTRPETLLGDTAVAVHP---------------------QDPRYK----------- 350
Query: 284 EEFKGEKLIGKYVRNPVTGDEV-IILPAEFVDPDNATGVVMSVPAHAPFDH 333
L GK+V++P + II VD + TG V PAH P D+
Sbjct: 351 ------HLHGKFVKHPFCNRSIPIICDDIIVDMEFGTGAVKITPAHDPNDY 395
>sp|P43824|SYI_HAEIN ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437547|pir||S78633 isoleucine--tRNA ligase (EC
6.1.1.5) - Haemophilus influenzae (strain Rd KW20)
Length = 941
Score = 96.7 bits (237), Expect = 1e-18
Identities = 171/853 (20%), Positives = 319/853 (37%), Gaps = 162/853 (18%)
Query: 15 KRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNV 74
K W E +++ K +K F + PY +G++H+GHA + D+I + K G++
Sbjct: 31 KNWYEKNLYQKIRKASKGKKSFILHDGPPYANGNIHIGHAVNKILKDIIIKSKTALGFDS 90
Query: 75 LFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYF---MK 131
+ GW G PI E + + P E + E +Y ++
Sbjct: 91 PYIPGWDCHGLPIELKVEGLVGK--------------PNEKISAAEFRQKCREYAAEQVE 136
Query: 132 AAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGT 191
K+ FIR G DW Y T F + I K+ E G++ KG+ V W G+
Sbjct: 137 GQKKDFIRLGVLGDWDNP-YLTMNFDTEANIIR-TLGKVIENGHLYKGSKPVHWCLDCGS 194
Query: 192 PLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPE----TVYGVTNMWINP-- 245
L + + +E ED + + ++F + DE +A R + + T W P
Sbjct: 195 SLAEAE-VEYED-KVSPSIYVRFPAESADEIEAKFSAQGRGQGKLSAIIWTTTPWTMPSN 252
Query: 246 -----NATYVKAKVKRGGKEETWIISKEAAYKL--SFQDREIEVIEEFKGEKLIGKYVRN 298
NA V+ G +E I++ E + + IE++ KG+ L +
Sbjct: 253 RAIAVNADLEYNLVQLG--DERVILAAELVESVAKAVGIEHIEILGSVKGDDLELSRFHH 310
Query: 299 PVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEE 358
P V ++ + V D TG+V + P H D + + +YD
Sbjct: 311 PFYDFTVPVILGDHVTTDGGTGLVHTAPDHGLDDFI----------VGKQYD-------- 352
Query: 359 ITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYH--KGIFKVPPYD 416
+ L+ +G K I E+ KG+F+ P
Sbjct: 353 LPMAGLVSNDG----------------------------KFISTTEFFAGKGVFEANPLV 384
Query: 417 GKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKE 476
+ +QEV L+ E ++ +I QWFI ++
Sbjct: 385 IEKLQEVGNLLKVEKIKHSYPHCWRH-----------KTPIIFRATPQWFIGMETQGLRQ 433
Query: 477 KARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYM 536
+A + +++ P+ +A+ E +++ +R+ G P+ E L T+ +
Sbjct: 434 QALGEIKQVRWIPDWGQARIEKMVENRPDWCISRQRTWGVPMTLFVHKETEELHPRTLDL 493
Query: 537 AYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKE 596
+ R+ G ++ + + EKEL G AE ++ +
Sbjct: 494 ----LEEVAKRVERAG----------------IQAWWDLDEKEL---LGADAETYRKVPD 530
Query: 597 EFEYWY-------------------PLDWRCSGKDLIPNHLTFFIFN-HVAIFREEHWP- 635
+ W+ +D G D H +F+ + ++ + P
Sbjct: 531 TLDVWFDSGSTYSSVVANRLEFNGQDIDMYLEGSD---QHRGWFMSSLMLSTATDSKAPY 587
Query: 636 KGIAVNGFGTLEGQ--KMSKSKGNVLNFIDAIEENGADVVRLYIMS---LAEHDSDFDWR 690
K + +GF T++GQ KMSKS GN++ + +++ G D++RL++ S E +
Sbjct: 588 KQVLTHGF-TVDGQGRKMSKSIGNIVTPQEVMDKFGGDILRLWVASTDYTGEMTVSDEIL 646
Query: 691 RKEVGKLRRQLERFYELISQFAEYEAKENV----ELKTIDKWLLHRLNKAIEGTTKALEE 746
++ RR L++ ++ K ++ ++ ++D+W + A A +
Sbjct: 647 KRAADSYRRIRNTARFLLANLNGFDPKRDLVKPEKMISLDRWAVACALDAQNEIKDAYDN 706
Query: 747 FRTRTAVQ----------WAFYSIMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAP 796
++ T VQ +FY + R Y + + + + L +A+ VR MAP
Sbjct: 707 YQFHTVVQRLMRFCSVEMGSFYLDIIKDRQYTTKADSLARRSCQTALWHIAEALVRWMAP 766
Query: 797 FTPHICEELWEKL 809
+E+W+ L
Sbjct: 767 ILSFTADEIWQHL 779
>emb|CAB75396.1| (AL139298) valyl tRNA synthetase [Streptomyces coelicolor A3(2)]
Length = 874
Score = 96.3 bits (236), Expect = 1e-18
Identities = 86/328 (26%), Positives = 141/328 (42%), Gaps = 64/328 (19%)
Query: 9 IEEKWQKRWLEAKVFEPNIK-DKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
+E + +RW+E FE + K DKP + + + P ++G LH+GHA +T+ D + R K
Sbjct: 25 VEGQLYERWVERGYFEADAKSDKPP---YTVVIPPPNVTGSLHLGHAFEHTLIDALTRRK 81
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
RMQGY L+ G G + ER + + H + V +V + W E
Sbjct: 82 RMQGYETLWQPGMDHAGIATQNVVERELGKEGKSRHDLGREAFVERVWQ---WKSESGGQ 138
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
I R G +V WSRE +T + S+ ++ F +L + I + +
Sbjct: 139 I--------SGQMRRLGDAVAWSRERFT--MDEGLSQAVQTIFKRLYDDELIYRAERIIN 188
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWIN 244
W P T + D ++ +D + ++ + EGDETI + AT R ET+ G T + ++
Sbjct: 189 WCPRCLTAISDIEVEYQDD----DGELVSMKYGEGDETIVV--ATTRAETMLGDTAVAVH 242
Query: 245 PNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDE 304
P E+ + + L+GK ++ P+T
Sbjct: 243 P--------------------------------------EDERYKHLVGKLIKLPLTDRS 264
Query: 305 VIILPAEFVDPDNATGVVMSVPAHAPFD 332
+ ++ E VDP+ TG V PAH P D
Sbjct: 265 IPVVADEHVDPEFGTGAVKVTPAHDPND 292
Score = 72.2 bits (174), Expect = 3e-11
Identities = 56/215 (26%), Positives = 101/215 (46%), Gaps = 18/215 (8%)
Query: 648 GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDF----DW---RRKEVGKLRRQ 700
G+KMSKS GNV+N +D +++ G+D +R + A D DW R K+
Sbjct: 529 GKKMSKSFGNVVNPLDWMDKYGSDALRFTLARGANPGVDVPIGEDWVQGSRNFANKIWNA 588
Query: 701 LERFYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSI 760
RF + E + + + D+W+L RLN + E+++ F+
Sbjct: 589 T-RFALMNGATVEGPLPDASRMSSTDRWILSRLNSVVAEVDAYYEDYQFAKLSDALFHFA 647
Query: 761 MNDL-RWYMRRTE------GRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEG 813
+++ WY+ ++ G E + VL ++ D+ +RL+ P P + E LW L G
Sbjct: 648 WDEVFDWYVELSKTTFQAGGEAAEVSKRVLGEVLDVTLRLLHPVVPFVTETLWTTLTGGE 707
Query: 814 FVSLAKWPEPVDEWWNEE-VEVEEDFIKSLIEDIK 847
V +A+W P D + + E E + ++S+I +++
Sbjct: 708 SVVIAEW--PTDSGFRDAGAEREIETVQSVITEVR 740
>dbj|BAA24690.1| (AB010832) ORF3; putative leucyl-tRNA synthase [Symbiobacterium
thermophilum]
Length = 143
Score = 96.3 bits (236), Expect = 1e-18
Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 28/165 (16%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+FR E +WQ+RW E +++ ++ K+Y FPY SG LH+GH R YTI DVIA
Sbjct: 7 DFREAEPRWQRRWDEEGIYK--VERDLSRPKYYALAMFPYPSGKLHMGHVRNYTIVDVIA 64
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
R++RM+GYNVL PMG+ G P A I++ +W ++ ++ ++
Sbjct: 65 RYRRMKGYNVLHPMGFDSFGMPAENAA--IQHGANPAVWTRENIAEMTAQLK-------- 114
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLK 169
+ G+S DWSR YT + ++ +W FL+
Sbjct: 115 --------------QMGYSYDWSRAVYTYR--EDYYRWTQWLFLQ 143
>sp|P56456|SYI_HELPY ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437556|pir||F64697 isoleucine--tRNA ligase (EC
6.1.1.5) - Helicobacter pylori (strain 26695)
>gi|2314596|gb|AAD08464.1| (AE000642) isoleucyl-tRNA
synthetase (ileS) [Helicobacter pylori 26695]
Length = 920
Score = 96.0 bits (235), Expect = 2e-18
Identities = 185/847 (21%), Positives = 328/847 (37%), Gaps = 127/847 (14%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N E K +W E + F+ K F + PY +GHLH+GHA + D++
Sbjct: 20 NLSVNEPKTYAKWQEQQAFKRMQARKDNHGDFTLHDGPPYANGHLHLGHALNKILKDIVV 79
Query: 65 RFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
+ + +G + + GW G PI I ER++ K E F +
Sbjct: 80 KREYFKGKKIYYTPGWDCHGLPIEQQILERLEKE------------KTSLENPTLFREKC 127
Query: 124 -NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
+ K F++ K F++ G D+ + T F I +++ +KG ++K H+
Sbjct: 128 RDHAKKFLEIQKNEFLQLGVLGDFEDPYKTMDF--KFEASIYRALVEVAKKG-LLKERHK 184
Query: 183 VRWDPVVGTPLGDHDLMEGEDVPILEY-------VIIKFEL-KEGDETIYLPAATL---- 230
P+ + + L E E +EY + + F L KE E + + A+L
Sbjct: 185 ----PIYWSYACESALAEAE----VEYKMKKSPSIFVAFGLKKESLEKLKVKKASLVIWT 236
Query: 231 -RPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKL-SFQDREIEVIEEFKG 288
P T+Y + + +A Y A ++G ++++K KL + + E+ EF
Sbjct: 237 TTPWTLYANVAIALKKDAVY--ALTQKG-----YLVAKALHEKLAALGVVDNEITHEFNS 289
Query: 289 EKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVK 348
L NP+ + ++ E V ++ TG V + P H D+ L+ E+L+
Sbjct: 290 NDLEYLVATNPLNQRDSLVALGEHVGLEDGTGAVHTAPGHGEEDYYL--GLRYNLEVLMS 347
Query: 349 YDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKA--EYH 406
D E I + L+ GE V + QK I+ D LEQ + Y H
Sbjct: 348 VDEKGCYDEGIIHNQLLDESYLGEH--VFKAQKRIIEQLGDSLLLEQEIEHSYPHCWRTH 405
Query: 407 KGIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEK-NVISRFGNRAVIKIIHDQ- 464
K + + + + I + +K + E+ + EK + G + +I ++
Sbjct: 406 KPVIYRATTQWFILMD-EPFIQNDGSQKTLREVALDAIEKVEFVPSSGKNRLKTMIENRP 464
Query: 465 -WFIDYGNSEWKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWDPE 523
W + +W + + P E + + +KK C
Sbjct: 465 DWCLS-RQRKWGVPLAFFIDKRTNKPCFESEVLEHVANLFEKKGC-------------DV 510
Query: 524 WVIESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSEEREKELEKK 583
W S+ D + +Y ++H ++ LD + F + LE++ E+ +
Sbjct: 511 WWEYSVKD-LLPPSYQEDAKHYEKIMH--ILDVWFDSGSTFKAV-LEDYHGEKGQS---- 562
Query: 584 TGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGF 643
P+++I E ++ W+ + L + N+ A F K + +GF
Sbjct: 563 ---PSDVILEGSDQHRGWFQ-----------SSLLIGCVLNNQAPF------KKVITHGF 602
Query: 644 GTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLE 702
E G+KMSKSKGNV++ ++ +G+DVVRL++ A +D D R + Q E
Sbjct: 603 IVDEKGEKMSKSKGNVVSLDKLLKTHGSDVVRLWV---AFNDYQNDLRVSQT--FFTQTE 657
Query: 703 RFYE--------LISQFAEYEAKENVE----LKTIDKWLLHRLNKAIEGTTKALEEFRTR 750
+ Y+ L++ F++ + K N+E +D ++L L G A EE
Sbjct: 658 QHYKKFRNTLKFLLANFSDMDLK-NLERPHNFSPLDHFMLETLETISAGVNSAFEEHDFV 716
Query: 751 TAVQWAFYSIMNDL----------RWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPH 800
+ + N+L Y +A + VL A +AP H
Sbjct: 717 KGLNILMAFVTNELSGIYLDACKDSLYCDSKNNEKRQAIQMVLLATASKLCYFLAPILTH 776
Query: 801 ICEELWE 807
EE+ E
Sbjct: 777 TIEEVLE 783
>sp|O66651|SYI_AQUAE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437546|pir||G70327 isoleucine--tRNA ligase (EC
6.1.1.5) - Aquifex aeolicus >gi|2983002|gb|AAC06614.1|
(AE000683) isoleucyl-tRNA synthetase [Aquifex aeolicus]
Length = 956
Score = 95.6 bits (234), Expect = 2e-18
Identities = 93/353 (26%), Positives = 146/353 (41%), Gaps = 54/353 (15%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
I EKW+ ++E K++ + F + PY +GH+HVGHA + DVI ++
Sbjct: 32 ILEKWKG------LYEKIQKERKGREVFVLHDGPPYANGHIHVGHALNKILKDVINKYNL 85
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV---NI 125
+ G NV F GW G PI E+ ++ K+ +E L E
Sbjct: 86 LIGKNVNFIPGWDCHGLPIERAVEKELSKK-----------KIKKESLPKTEFRELCREY 134
Query: 126 VKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRW 185
K ++ +E F+R G DW + T + P + + K E+G + V W
Sbjct: 135 AKKYVNIQREDFVRLGVLGDWEHPYLT--MDPKYEAQEIRELGKFFERGLAYRSKKPVYW 192
Query: 186 DPVVGTPLGDHDL--MEGEDVPILEYVIIKFELKEG------DETIYLPAATLRPETVYG 237
T + ++ E ED I +KF LK G D+ ++ T P T+
Sbjct: 193 CIYDKTAEAEAEVEYYEKEDPSI----YVKFPLKSGEKFGIKDKKVFAIIWTTTPWTLPA 248
Query: 238 VTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKL--SFQDREIEVIEEFKGEKLIGKY 295
+ + +A YV +V ++E WI++KE K + E V+E KG+ L+G
Sbjct: 249 NLGIMVKEDADYVLVEV----EDEVWIVAKELMDKFFETVNRPEGLVLETVKGKDLVGLE 304
Query: 296 VRNPVTGDEVI--------------ILPAEFVDPDNATGVVMSVPAHAPFDHV 334
+P E + I P+EFV D TG+V P H D+V
Sbjct: 305 YTHPFVEKEKLKGHLSEETLKNMWKIYPSEFVSLDTGTGLVHMAPGHGQEDYV 357
>gb|AAG20602.1| (AE005130) valyl-tRNA synthetase; ValS [Halobacterium sp. NRC-1]
Length = 881
Score = 95.6 bits (234), Expect = 2e-18
Identities = 71/241 (29%), Positives = 114/241 (46%), Gaps = 24/241 (9%)
Query: 8 AIEEKWQKRWLEAKV--FEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIAR 65
+IE KWQ W E V F+P+ D ++ I PY SG+LH+GHA ++ D +AR
Sbjct: 12 SIEPKWQDEWQERDVYRFDPSESDT----QYVIDTPPPYPSGNLHLGHALGWSYIDFVAR 67
Query: 66 FKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNI 125
++R++G VLFP GW G P E + D H + D ++ I WT ED ++
Sbjct: 68 YRRLKGDAVLFPQGWDCHGLPTEVKVEEV--NDIHRTDVPSDEFR-EMCIDWT-EDRIDE 123
Query: 126 VKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRW 185
+K M+ GFS DW E+ T + P + + F ++ + G + + H V W
Sbjct: 124 MKATMQ-------ELGFSQDWDSEYRT--MDPEYWGKTQESFSEMADAGMVYRDEHPVNW 174
Query: 186 DPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINP 245
P T + D ++ + L YV +G + + AT RPE + + ++P
Sbjct: 175 CPRCETAIADAEVENIDREGTLHYVTF-----DGVDNGDIEIATTRPELLAACVGIVVSP 229
Query: 246 N 246
+
Sbjct: 230 D 230
Score = 87.4 bits (213), Expect = 7e-16
Identities = 79/272 (29%), Positives = 129/272 (47%), Gaps = 31/272 (11%)
Query: 596 EEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNG--FGTLEGQKMSK 653
+EFE +D R G D+I + + A+ E+ W + VNG FG +G KMSK
Sbjct: 477 DEFE---SVDLRPQGHDIIRTWAFYTLLRTGALTDEQPWDD-VLVNGMVFGE-DGNKMSK 531
Query: 654 SKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYELISQFA- 712
S+GN + +AI E AD VR + SD ++ KEV R L + + I++F+
Sbjct: 532 SRGNFVQPDEAIAEYSADAVRQALALGGRPGSDVQFQWKEVKSASRFLTKLWN-ITKFST 590
Query: 713 -----EYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFR----TRTAVQWAFYSIMND 763
+ A ++ + D+WLL L+ E +A+ E+R R+ ++A+ + +D
Sbjct: 591 GHFDEDTPAIQDPAYRDADRWLLSELSTVCEDVDEAMSEYRFDRALRSLREFAWEDLADD 650
Query: 764 LRWYMRRTEGR-------DDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKL-GGEGFV 815
Y+ +GR + A L RL+APF+PH EE+W+ L G EG V
Sbjct: 651 ---YVELVKGRLYNGRPGERAAAEHTLYTAVTAVTRLLAPFSPHTTEEIWQSLPGTEGSV 707
Query: 816 SLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIK 847
A +P E+ + + E+ I + +I+
Sbjct: 708 HAATFPSV--EYRDADAELAGKRIAEVAREIR 737
>gi|6323414 mitochondrial leucyl tRNA synthetase; Nam2p [Saccharomyces
cerevisiae] >gi|135144|sp|P11325|SYLM_YEAST LEUCYL-TRNA
SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--TRNA
LIGASE) (LEURS) >gi|68518|pir||SYBYLM leucine--tRNA
ligase (EC 6.1.1.4) precursor, mitochondrial - yeast
(Saccharomyces cerevisiae) >gi|4021|emb|CAA28791.1|
(X05143) ORF2 (AA 1-894) for mitochon- drial leucyl tRNA
synthetase [Saccharomyces cerevisiae]
>gi|172008|gb|AAA34805.1| (J03495) leucyl-tRNA
synthetase [Saccharomyces cerevisiae]
>gi|609429|gb|AAB67277.1| (U19104) Nam2p: mitochondrial
leucyl-tRNA synthetase [Saccharomyces cerevisiae]
Length = 894
Score = 95.2 bits (233), Expect = 3e-18
Identities = 64/191 (33%), Positives = 88/191 (45%), Gaps = 30/191 (15%)
Query: 8 AIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFK 67
AI EKW+++ + + K YI FPY SG LH+GH R Y I D + RF
Sbjct: 25 AIGEKWKQKTTRGLPKQDTLNSGSK----YILCQFPYPSGALHIGHLRVYVISDSLNRFY 80
Query: 68 RMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
+ +GYNV+ PMGW G P A I R + +WT + NI K
Sbjct: 81 KQKGYNVIHPMGWDAFGLPAENAA------------IERSI----NPAIWTRD---NIAK 121
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
MK ++ + + DW RE T+ P + KF +W FLKL E G + + WDP
Sbjct: 122 --MKQQMQSMLA---NFDWDREI--TTCDPEYYKFTQWIFLKLFENGLAYRKEAEINWDP 174
Query: 188 VVGTPLGDHDL 198
V T L + +
Sbjct: 175 VDMTVLANEQV 185
>sp|Q9ZJJ1|SYI_HELPJ ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|7437555|pir||F71823 isoleucine--tRNA ligase (EC
6.1.1.5) - Helicobacter pylori (strain J99)
>gi|4155922|gb|AAD06890.1| (AE001554) ISOLEUCYL-TRNA
SYNTHETASE [Helicobacter pylori J99]
Length = 920
Score = 95.2 bits (233), Expect = 3e-18
Identities = 183/871 (21%), Positives = 333/871 (38%), Gaps = 175/871 (20%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N E K +W E + F+ K F + PY +GHLH+GHA + D++
Sbjct: 20 NLSVNEPKTYAKWQEQQAFKRMQNRKDNHGDFTLHDGPPYANGHLHLGHALNKILKDIVI 79
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV- 123
+ + +G + + GW D H + I + + + E+ + E+P
Sbjct: 80 KREYFKGKKIYYTPGW-----------------DCHGLPIEQQILEQLEKEKTSLENPTL 122
Query: 124 ------NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
+ K F++ K F++ G D+ + T F I + + +KG ++
Sbjct: 123 FREKCRDHAKKFLEIQKNEFLQLGVLGDFEDPYKTMDF--KFEASIYRALVGVAKKG-LL 179
Query: 178 KGAHRVRWDPVVGTPLGDHDLMEGEDVPILEY-------VIIKFEL-KEGDETIYLPAAT 229
K H+ P+ + + L E E +EY + + F+L KEG E + + A+
Sbjct: 180 KERHK----PIYWSYACESALAEAE----VEYKMKKSPSIFVAFDLKKEGLEKLKVKKAS 231
Query: 230 L-----RPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKL-SFQDREIEVI 283
L P T+Y + + +A Y A ++G ++++K KL + + +
Sbjct: 232 LVIWTTTPWTLYANVAIALKKDAVY--ALTQKG-----YLVAKALHEKLAALGVVDNAIT 284
Query: 284 EEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRES 343
EF L NP+ + +++ + V ++ TG V + P H D+ LK
Sbjct: 285 HEFNSNDLEYLVATNPLNQRDSLVVLGDHVSLEDGTGAVHTAPGHGEEDYYL--GLKYHL 342
Query: 344 EILVKYDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDREKLEQATKTIYKA 403
E+L+ D E I + L+ GE + + QK I+ D LE+ + Y
Sbjct: 343 EVLMSVDEKGCYDEGIIHNQLLDKSYLGEH--IFKAQKRIIEQLGDSLLLEREIEHSYPH 400
Query: 404 EYHKGIFKVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRAVIKIIHD 463
+ K VI R + I+ D
Sbjct: 401 CWR-------------------------------------THKPVIYRATTQWF--ILMD 421
Query: 464 QWFIDYGNSE--WKEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLGTPLPWD 521
+ FI S+ +E A A+ +++ P + + + + +I+ +R+ G PL
Sbjct: 422 EPFIQNDGSQKTLREVALDAIEKVEFVPSSGKNRLKTMIENRPDWCLSRQRKWGVPL--- 478
Query: 522 PEWVIESLSDSTIYMAYYTISRHINRLREEGRLD-------PEKLTPEFFDYIFLEE--- 571
+ I+ ++ + + + H+ L EE D + L P + D E
Sbjct: 479 -AFFIDKRTNKPCFES--EVLEHVANLFEEKGCDVWWEYNIKDLLPPSYQDNAKHYEKVM 535
Query: 572 ------------FSEEREKELEKKTGIPAEIIHEMKEEFEYWYPLDWRCSGKDLIPNHLT 619
F E +K P++++ E ++ W+ + L
Sbjct: 536 HILDVWFDSGSTFKAVLEDYHGEKGQSPSDVVLEGSDQHRGWFQ-----------SSLLI 584
Query: 620 FFIFNHVAIFREEHWPKGIAVNGFGTLE-GQKMSKSKGNVLNFIDAIEENGADVVRLYIM 678
+ N+ A F K + +GF E G+KMSKSKGNV++ + ++++G+DVVRL++
Sbjct: 585 GCVLNNQAPF------KKVITHGFIVDEKGEKMSKSKGNVVSLDNLLKKHGSDVVRLWV- 637
Query: 679 SLAEHDSDFDWRRKEVGKLRRQLERFYE--------LISQFAEYEAKENVE----LKTID 726
A +D D R + + Q E+ Y+ L++ F++ + K N+E +D
Sbjct: 638 --AFNDYQNDLRVSQTFFI--QTEQHYKKFRNTLKFLLANFSDMDLK-NLERPHDFSPLD 692
Query: 727 KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL----------RWYMRRTEGRDD 776
++L L G A EE + + N+L Y
Sbjct: 693 HFILEALETISAGVNSAFEEHDLVKGLNILMAFVTNELSGIYLDACKDSLYCDSKNNEKR 752
Query: 777 EAKRFVLRKLADIWVRLMAPFTPHICEELWE 807
+A + VL +A +AP H EE+ E
Sbjct: 753 QAIQMVLLAVASQLCYFLAPILTHTIEEVLE 783
>sp|O67646|SYLB_AQUAE LEUCYL-TRNA SYNTHETASE BETA SUBUNIT (LEUCINE--TRNA LIGASE BETA
SUBUNIT) (LEURS) >gi|7519892|pir||D70452 leucine--tRNA
ligase (EC 6.1.1.4) beta chain - Aquifex aeolicus
>gi|2984068|gb|AAC07608.1| (AE000755) leucyl-tRNA
synthetase beta subunit [Aquifex aeolicus]
Length = 289
Score = 94.8 bits (232), Expect = 4e-18
Identities = 65/196 (33%), Positives = 107/196 (54%), Gaps = 14/196 (7%)
Query: 647 EGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE 706
E KMSKSK NV++ +A+E+ GAD VRLYI+ A + DF+W + + R L+R++
Sbjct: 42 ESAKMSKSKANVVDPEEAVEKYGADTVRLYILFAAPPEQDFEWTDEGIQGAYRFLQRYWN 101
Query: 707 LISQFAE------YEAKENVELKTIDKWLLHRLNKAIEGTTKALEE-FRTRTAVQWAFYS 759
+++ E Y +E ++ K + +++ I + EE ++ TA+
Sbjct: 102 FVNKHLEKIKNLTYTVEELRNVQGKAKEVRREIHQTIADYRRDFEERYQFNTAIA-KIMK 160
Query: 760 IMNDLRWYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAK 819
++N L+ + +TE +D + VLR+ + L++P TPHI EE+WE LG EGF+
Sbjct: 161 LLNTLQDFSPQTE-QDYK----VLREGIETITLLLSPITPHIAEEVWEMLGNEGFIINQP 215
Query: 820 WPEPVDEWWN-EEVEV 834
PEP E EE+E+
Sbjct: 216 IPEPDPEALKVEEIEI 231
>sp|Q9Z987|SYV_CHLPN VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437658|pir||B72120 valine--tRNA ligase (EC 6.1.1.9)
[similarity] - Chlamydophila pneumoniae (strains CWL029
and AR39) >gi|4376354|gb|AAD18247.1| (AE001595) Valyl
tRNA Synthetase [Chlamydophila pneumoniae CWL029]
>gi|7189594|gb|AAF38490.1| (AE002226) valyl-tRNA
synthetase [Chlamydophila pneumoniae AR39]
>gi|8978467|dbj|BAA98304.1| (AP002545) alyl tRNA
synthetase [Chlamydophila pneumoniae J138]
Length = 940
Score = 94.0 bits (230), Expect = 7e-18
Identities = 90/334 (26%), Positives = 143/334 (41%), Gaps = 61/334 (18%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIK-DKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
NF+ E + W + +F+ DKP + + + P ++G LH+GHA T+ DV+
Sbjct: 11 NFQDTEPELYVFWEKNGMFKAEASSDKPP---YSVIMPPPNVTGVLHMGHALVNTLQDVL 67
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWTFE 120
R+KRM G+ V + G G + ER T + D K +W ++
Sbjct: 68 VRYKRMSGFEVCWIPGTDHAGIATQAVVERHLQASEGKRRTDYSREDFLK----HIWAWK 123
Query: 121 DPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
+ K + G S DW R+ +T + P ++ ++ F L E GYI +G
Sbjct: 124 EKSE------KVVLSQLRQLGCSCDWDRKRFT--MEPLANRAVKKAFKTLFENGYIYRGY 175
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTN 240
+ V WDPV+ T L D ++ E L Y I++ + E+I + AT RPET G T
Sbjct: 176 YLVNWDPVLQTALADDEVEYEEKDGWLYY--IRYRMVGSQESIVV--ATTRPETSLGDTG 231
Query: 241 MWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPV 300
+ ++PN + +WI A+ ++ F +R+I P+
Sbjct: 232 IAVSPN----------DERYASWI---GASVEVPFVNRQI------------------PI 260
Query: 301 TGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHV 334
GD VDP TG V PAH D++
Sbjct: 261 IGD-------ASVDPTFGTGAVKVTPAHDKDDYL 287
>dbj|BAB10327.1| (AB017061) isoleucyl-tRNA synthetase [Arabidopsis thaliana]
Length = 988
Score = 92.4 bits (226), Expect = 2e-17
Identities = 93/386 (24%), Positives = 163/386 (42%), Gaps = 42/386 (10%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
E + QK W E +VF+ + D F + PY +G LH+GHA + D+I R+K +
Sbjct: 38 EPELQKLWEENQVFK-RVSDNNNGGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLL 96
Query: 70 QGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEI--LWTFEDPVNIVK 127
Q Y V + GW G PI + +++ D +V +E+ L K
Sbjct: 97 QNYKVQYVPGWDCHGLPIE--LKVLQSLD----------QEVRKELTPLKLRAKAAKFAK 144
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
+K E+F R G DW+ + T L P + F ++ KGYI +G V W P
Sbjct: 145 ATVKTQMESFKRFGVWADWNNPYLT--LDPEYEAAQIEVFGQMALKGYIYRGRKPVHWSP 202
Query: 188 VVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDET---------IYLPAATLRPETVYGV 238
T L + +L E + I + + F+L G +T IYL T P T+
Sbjct: 203 SSRTALAEAEL-EYPEGHISKSIYAIFKLVGGAKTSLLDEFIPNIYLAVWTTTPWTMPAN 261
Query: 239 TNMWINPNATYVKAKVKRGGKEETWII-------SKEAAYKLSFQDREIEVIEEFKGEKL 291
+ +N Y +V+ +++ ++I + EA + + ++ + + F G L
Sbjct: 262 AAVAVNAKLQYSVVEVQSFNQQKLFVIVATDLVPALEAKWGV-----KLSISKTFLGSDL 316
Query: 292 IGKYVRNPVTG-DEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYD 350
+P+ D +++ +++ ++ TG+V + P H D+ LK ++ D
Sbjct: 317 ENCRYTHPIDNRDCPVVIGGDYITTESGTGLVHTAPGHGQEDYAT--GLKYGLPLVSPVD 374
Query: 351 IDPRIVEEITYISLIKLEGYGEFPAV 376
+ + EE + + G G V
Sbjct: 375 DEGKFTEEAGQFRGLSVLGEGNTAVV 400
>pir||T51503 valine--tRNA ligase-like protein - Arabidopsis thaliana
>gi|9755723|emb|CAC01835.1| (AL391147) valine--tRNA
ligase-like protein [Arabidopsis thaliana]
Length = 1093
Score = 91.7 bits (224), Expect = 4e-17
Identities = 86/332 (25%), Positives = 143/332 (42%), Gaps = 57/332 (17%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
EEK K W F+PN F I + P ++G LH+GHA T+ D++ R+ RM
Sbjct: 287 EEKIYKWWESQGYFKPNFDQGGSP--FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRM 344
Query: 70 QGYNVLFPMGWHITGSPIVGIAER-IKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
G L+ G G + E+ + + + + RD + + +W +++ KY
Sbjct: 345 NGRPTLWLPGTDHAGIATQLVVEKMLASEGIKRVDLGRDEF---TKRVWEWKE-----KY 396
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+ R G S DWSRE +T L S+ + F+KL +KG I +G++ V W P
Sbjct: 397 GGTITNQ-IKRLGASCDWSRERFT--LDEQLSRAVVEAFVKLHDKGLIYQGSYMVNWSPN 453
Query: 189 VGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNAT 248
+ T + D ++ E+ L + IK+ + + +L AT RPET++G + ++P
Sbjct: 454 LQTAVSDLEVEYSEEPGFLYH--IKYRVAGSPD--FLTIATTRPETLFGDVALAVHP--- 506
Query: 249 YVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVT-GDEVII 307
E+ + K +G+ P+T G V I
Sbjct: 507 -----------------------------------EDDRYSKYVGQTAIVPMTYGRHVPI 531
Query: 308 LPAEFVDPDNATGVVMSVPAHAPFDHVALEDL 339
+ ++VD D TGV+ P H D++ L
Sbjct: 532 IADKYVDKDFGTGVLKISPGHDHNDYLLARKL 563
>sp|P47508|SYL_MYCGE LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|1361707|pir||D64229 leucine--tRNA ligase (EC
6.1.1.4) - Mycoplasma genitalium
>gi|3844862|gb|AAC71488.1| (U39706) leucyl-tRNA
synthetase (leuS) [Mycoplasma genitalium]
Length = 792
Score = 91.3 bits (223), Expect = 5e-17
Identities = 99/416 (23%), Positives = 163/416 (38%), Gaps = 90/416 (21%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVI 63
N IEEKW K+W V + +KK+Y+ FPY S LH+GH R YTI DVI
Sbjct: 3 NHNLIEEKWLKKWKNKDV--NRFESDSNKKKYYVLDMFPYPSAAGLHLGHVRAYTITDVI 60
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
+R+ + +G+NV+ P+G+ G P A N++P + WT ++
Sbjct: 61 SRYYKAKGFNVIHPIGFDAFGLPAEQYAIN-SNQNPGS---------------WTDQNIN 104
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
N + GF D+ TT P + K+ +W F +L + V
Sbjct: 105 NFINQLTS--------FGFDYDYHLSLKTTD--PRYYKYTQWIFSELFKANLAELVDIDV 154
Query: 184 RWDPVVGTPLGDHD------------------------------------LMEGEDV--- 204
W +GT L + + L+EG D
Sbjct: 155 NWCEQLGTVLANEEVLIDSNGNAVSERGSFSVEKRKMKQWVLKITTFADALLEGLDTLDW 214
Query: 205 --PILEY----------VIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKA 252
PI E V I F+LK+ E I + T +P+T++GV+ + ++ N K
Sbjct: 215 PEPIKEMQRNWIGKSKGVTINFQLKDHKEAIAI--FTTKPQTIFGVSFLAVSTNHWLAK- 271
Query: 253 KVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEF 312
K+ K+ + K+ + + + + G L+ + +P+T + + + A +
Sbjct: 272 KIAETNKKVASFLKKQLQKTTTLKQK----ATLYDGIDLLTNAI-HPLTNELIPVYVANY 326
Query: 313 VDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLE 368
V T +M V AH D+ K++ +I+ D R+ Y L E
Sbjct: 327 VIEGYGTDAIMGVGAHNENDNFFAR--KQKLKIINVIDKKERLQNSFAYNGLTTKE 380
>sp|P93736|SYV_ARATH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|1890130|gb|AAB49704.1| (U89986) valyl tRNA
synthetase [Arabidopsis thaliana]
Length = 1107
Score = 90.5 bits (221), Expect = 8e-17
Identities = 93/344 (27%), Positives = 145/344 (42%), Gaps = 77/344 (22%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
+E+ W W ++ +F+ + K + F I + P ++G LH+GHA T I D I R+KR
Sbjct: 145 VEKSWYAWWEKSDLFKADAKSS--KPPFVIVLPPPNVTGALHIGHALTSAIEDTIIRWKR 202
Query: 69 MQGYNVLFPMGWHITGSPIVGIAER--IKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIV 126
M GYN L+ G G + E+ +++R + R+ + V E W + I+
Sbjct: 203 MSGYNALWVPGVDHAGIATQVVVEKKIMRDRGMTRHDVGREEF-VKEVWKWKNQYGGTIL 261
Query: 127 KYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWD 186
R G S+DWSRE +T + SK + F++L ++G I + V WD
Sbjct: 262 TQLR--------RLGASLDWSRECFT--MDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWD 311
Query: 187 PVVGTPLGDHDLMEGEDVPILEYVIIK-----------------FELKEGDETIYLPAAT 229
++ T + D +E E + I E ++K + L+E I AT
Sbjct: 312 CILRTAISD---VEVEYIDIKEKTLLKVPGYEKPVEFGLLTSFAYPLEELGRVI---VAT 365
Query: 230 LRPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGE 289
R ET+ G T + I+P+ +A YK
Sbjct: 366 TRVETMLGDTAIAIHPD---------------------DARYK----------------- 387
Query: 290 KLIGKYVRNPVTGDEV-IILPAEFVDPDNATGVVMSVPAHAPFD 332
L GK+ +P G ++ II VDP+ TG V PAH P D
Sbjct: 388 HLHGKFAVHPFNGRKLPIICDGILVDPNFGTGCVKITPAHDPND 431
>sp|P28350|SYV_NEUCR VALYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (VALINE--TRNA
LIGASE) (VALRS) >gi|101878|pir||A41251 valine--tRNA
ligase (EC 6.1.1.9) - Neurospora crassa
Length = 1093
Score = 90.1 bits (220), Expect = 1e-16
Identities = 84/346 (24%), Positives = 143/346 (41%), Gaps = 79/346 (22%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N A+E W + W +A F+P KP KF I + P ++G LH GHA ++ D +
Sbjct: 141 NPSAVEAAWYQWWEKAGYFKPESCRKPSAGKFVIPLPPPNVTGALHCGHALANSLQDTLI 200
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEE--------IL 116
R+ RM+GY L+ G G + E++ +++ K+ +E ++
Sbjct: 201 RWYRMKGYETLWVPGCDHAGISTQSVVEKM---------LWKKEKKIRQELGREKFTDLV 251
Query: 117 WTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYI 176
W ++ +Y + + G S+DWSRE +T + + F +L ++G I
Sbjct: 252 WEWKG-----EYHQRINNAQKLMGG-SMDWSREAFT--MDKNLTAATMETFCRLHDEGLI 303
Query: 177 VKGAHRVRWDPVVGTPLGDHDLMEGE-------DVP----ILEYVII---KFELKEGDET 222
+ V W + T L ++ E DVP +E+ ++ K+++ +ET
Sbjct: 304 YRSNRLVNWCTHLNTALSGLEVETKEITGRTLLDVPGYDKKVEFGVLTHFKYQIDGSEET 363
Query: 223 IYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEV 282
I AT RPET+ G T + +NP
Sbjct: 364 I--EVATTRPETMLGDTGIAVNP------------------------------------- 384
Query: 283 IEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAH 328
E+ + L+GK+ R+P + I+ +VD + TG V PAH
Sbjct: 385 -EDPRYTHLVGKFARHPFVDRLLPIVTDNYVDKEFGTGAVKLTPAH 429
>gi|6319395 cytoplasmic isoleucyl-tRNA synthetase; Ils1p [Saccharomyces
cerevisiae] >gi|135134|sp|P09436|SYIC_YEAST
ISOLEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (ISOLEUCINE--TRNA
LIGASE) (ILERS) >gi|68524|pir||SYBYI4 isoleucine--tRNA
ligase (EC 6.1.1.5) - yeast (Saccharomyces cerevisiae)
>gi|3820|emb|CAA30733.1| (X07886) ILSI (AA 1-1072)
[Saccharomyces cerevisiae] >gi|498991|emb|CAA56034.1|
(X79489) ILS1 protein [Saccharomyces cerevisiae]
>gi|536123|emb|CAA84898.1| (Z35838) ORF YBL076c
[Saccharomyces cerevisiae]
Length = 1072
Score = 89.7 bits (219), Expect = 1e-16
Identities = 87/347 (25%), Positives = 150/347 (43%), Gaps = 35/347 (10%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNI---KDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
+F EEK W E F ++ KDKP+ F P+ +G H GH TI D
Sbjct: 9 SFPKEEEKVLSLWDEIDAFHTSLELTKDKPE---FSFFDGPPFATGTPHYGHILASTIKD 65
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWT 118
++ R+ M G++V GW G PI I ++ I +D DV+K E
Sbjct: 66 IVPRYATMTGHHVERRFGWDTHGVPIEHIIDKKLGITGKD--------DVFKYGLENY-- 115
Query: 119 FEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVK 178
+ +IV + ++T R G +D+ ++ T ++P F + W F +L EKG + +
Sbjct: 116 NNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKT--MYPSFMESTWWAFKQLHEKGQVYR 173
Query: 179 GAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGV 238
G + + + TPL + + + V I F + G E L A T P T+
Sbjct: 174 GFKVMPYSTGLTTPLSNFEAQQNYKDVNDPAVTIGFNV-IGQEKTQLVAWTTTPWTLPSN 232
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSF---QDREIEVIEEFKGEKLIG-- 293
++ +N + YVK + + + I E+ K + ++ + +++E+ KG L+G
Sbjct: 233 LSLCVNADFEYVKIYDE---TRDRYFILLESLIKTLYKKPKNEKYKIVEKIKGSDLVGLK 289
Query: 294 -----KYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVA 335
Y ++ ++V D+ TG+V + PA D+ A
Sbjct: 290 YEPLFPYFAEQFHETAFRVISDDYVTSDSGTGIVHNAPAFGEEDNAA 336
>gb|AAF51821.1| (AE003597) CG11471 gene product [alt 1] [Drosophila melanogaster]
>gi|7296538|gb|AAF51822.1| (AE003597) CG11471 gene
product [alt 2] [Drosophila melanogaster]
>gi|7296539|gb|AAF51823.1| (AE003597) CG11471 gene
product [alt 3] [Drosophila melanogaster]
Length = 1081
Score = 88.2 bits (215), Expect = 4e-16
Identities = 89/375 (23%), Positives = 157/375 (41%), Gaps = 34/375 (9%)
Query: 1 MPE-LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTI 59
+PE +NF A EE ++W +FE + + K+ P+ +G H GH TI
Sbjct: 13 VPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTI 72
Query: 60 PDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTF 119
D++ R+ QGY+V GW G P+ +++ N K PE++
Sbjct: 73 KDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLN------------IKGPEDVAKMG 120
Query: 120 EDPVN-----IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKG 174
N IV + + R G +D+ ++ T L+P + + I W F +L +KG
Sbjct: 121 IAAYNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKT--LYPWYMESIWWIFKQLFDKG 178
Query: 175 YIVKGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPET 234
+ +G + + T L + + + + V++ E T +L T P T
Sbjct: 179 LVYQGVKVMPYSTACTTSLSNFEANQNYKEVVDPCVVVALEAVSLPNTFFL-VWTTTPWT 237
Query: 235 VYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGK 294
+ ++P TYV KV+ + +++++ + + E EV E+F G+ L
Sbjct: 238 LPSNFACCVHPTMTYV--KVRDVKSDRLFVLAESRLSYVYKSETEYEVKEKFVGKTLKDL 295
Query: 295 YVRN-----PVTGDEV---IILPAEFVDPDNATGVVMSVPAHAPFDH---VALEDLKRES 343
+ + G EV +L E+V D+ TG+V + P D+ +A + + S
Sbjct: 296 HYKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSS 355
Query: 344 EILVKYDIDPRIVEE 358
E+L D R E
Sbjct: 356 EVLCPVDEAGRFTNE 370
>gb|AAD50458.1|AF169967_1 (AF169967) LeuS [Flavobacterium johnsoniae]
Length = 233
Score = 87.8 bits (214), Expect = 5e-16
Identities = 62/177 (35%), Positives = 84/177 (47%), Gaps = 22/177 (12%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVI 63
N IE KWQK W E + F K+ ++ K Y+ FPY SG LHVGH Y DV
Sbjct: 4 NPNEIEAKWQKYWAENQTFAA--KNNSEKPKHYVLDMFPYPSGAGLHVGHPLGYIASDVY 61
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRD--VYKVPEEILWTFED 121
+RFKR QG+NVL PMG+ G P A + R T + D V K ++I
Sbjct: 62 SRFKRHQGFNVLHPMGYDSFGLPAEQYAIQTGQRPEDTTRVNIDGGVDKEGKQI------ 115
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVK 178
++ + GFS DW+RE T++ P + K +W F++L Y K
Sbjct: 116 ---------AGYRKQLDKIGFSFDWAREVRTSN--PDYYKHTQWIFIQLFNSWYCRK 161
>pir||S77840 probable leucine--tRNA ligase (EC 6.1.1.4) - Mycoplasma capricolum
(fragment) >gi|530407|emb|CAA83690.1| (Z33008) Leu-tRNA
synthetase [Mycoplasma capricolum]
Length = 132
Score = 87.0 bits (212), Expect = 9e-16
Identities = 53/151 (35%), Positives = 73/151 (48%), Gaps = 28/151 (18%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPD 61
+ + +AIE+KWQK W E V++ + KK Y+ FPY SG LHVGH + YT D
Sbjct: 2 DFSHKAIEKKWQKYWKENNVYKTTDSN---HKKAYVLDMFPYPSGAGLHVGHIKGYTATD 58
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFED 121
V +RFKRMQGY+VL P+GW G P + L T D
Sbjct: 59 VYSRFKRMQGYDVLHPIGWDAFGLP------------------------AEQYALKTGND 94
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYT 152
P + ++ K ++ GFS D+ +E T
Sbjct: 95 PRDFTLKNIENFKAQLVKMGFSYDYDKEINT 125
>sp|P47576|SYV_MYCGE VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|1361896|pir||I64236 valine--tRNA ligase (EC 6.1.1.9)
- Mycoplasma genitalium >gi|3844913|gb|AAC71557.1|
(U39714) valyl-tRNA synthetase (valS) [Mycoplasma
genitalium]
Length = 837
Score = 87.0 bits (212), Expect = 9e-16
Identities = 85/348 (24%), Positives = 136/348 (38%), Gaps = 65/348 (18%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+F + + + W A F+P K K F + P L+G LH+GHA +I D I
Sbjct: 12 DFNLVSDGLYEIWNNAGFFKP----KDKNNSFTAILPPPNLTGTLHIGHAFEVSITDQIM 67
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVN 124
RFK+MQG+++ + G+ G E+I ++ + D K + W
Sbjct: 68 RFKKMQGFSINWIPGFDHAGIATQTKYEKIALKENQKYFDADDDKKSEMIMNWALNQS-E 126
Query: 125 IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVR 184
I+K +K+ G ++WS +T S +K + F L E G+I + V
Sbjct: 127 IIKNQLKS-------LGVCLNWSETKFTLS--EQANKIVNNCFKNLYENGFIYQAYTLVN 177
Query: 185 WDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWIN 244
WD + T + + +++ L YV+ K E I AT RPET++ + +N
Sbjct: 178 WDTKLNTAISNIEVINKPVNQHLHYVVYKLANDSKQELI---VATTRPETIFADVCLLVN 234
Query: 245 PNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDE 304
P K+ Y K V NP+TG +
Sbjct: 235 P---------------------KDKRY-----------------TNFWNKLVVNPLTGKQ 256
Query: 305 VIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDID 352
+ ++ +VD TG++ PAH D+ EI KY D
Sbjct: 257 IPVVTDSYVDIKFGTGILKCTPAHDFNDY----------EINTKYKFD 294
>pir||H81686 valyl-tRNA synthetase TC0576 [imported] - Chlamydia muridarum
(strain Nigg) >gi|7190615|gb|AAF39411.1| (AE002326)
valyl-tRNA synthetase [Chlamydia muridarum]
Length = 939
Score = 86.2 bits (210), Expect = 2e-15
Identities = 85/300 (28%), Positives = 142/300 (47%), Gaps = 45/300 (15%)
Query: 32 KEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIA 91
K+ + I + P ++G LH+GHA T+ D++ R+KRM+G+ V + + G+ GIA
Sbjct: 36 KKPAYSIVMPPPNVTGILHMGHALVNTLQDMLIRYKRMKGFEVCW-----VPGTDHAGIA 90
Query: 92 -ERIKNRDPHTIWIYRDVYKVPEEIL---WTF-EDPVNIVKYFMKAAKETFIRAGFSVDW 146
+ + R + R EE L W + E N++ ++ + G S DW
Sbjct: 91 TQTVVERHLRSSLGKRRTDFSREEFLKHVWEWKEKSQNVILSQLR-------QLGCSCDW 143
Query: 147 SREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGEDVPI 206
SR+ +T + P ++ ++ F L +KG I +G + V WDP++ T L D ++ E
Sbjct: 144 SRQRFT--MDPEANRAVKKAFKVLFDKGVIYRGYYLVNWDPILQTALADDEVEYEEREGW 201
Query: 207 LEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEETWIIS 266
L Y I++ + +E ++ AT RPET+ G T + ++P ++E +
Sbjct: 202 LYY--IRYPVVNSEE--FITVATTRPETLLGDTAIAVSP-------------EDERYSHL 244
Query: 267 KEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVP 326
A + F DREI +I +F + G TG V I PA D D TG+ +P
Sbjct: 245 IGAKVIVPFVDREIPIIGDFSVDASFG-------TG-AVKITPAHDKD-DYRTGMNHRLP 295
>sp|P96142|SYV_THETH VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|1814011|emb|CAA71837.1| (Y10900) valyl-tRNA
synthetase [Thermus thermophilus]
Length = 854
Score = 86.2 bits (210), Expect = 2e-15
Identities = 92/375 (24%), Positives = 152/375 (40%), Gaps = 88/375 (23%)
Query: 7 RAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARF 66
+++E KW ++W + KP F I + P ++G LH+GHA ++ D + R+
Sbjct: 10 KSVEPKWAEKWAKNPFVANPKSGKPP---FVIFMPPPNVTGSLHMGHALDNSLQDALIRY 66
Query: 67 KRMQGYNVLFPMGWHITGSPIVGIAERI---KNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
KRM+G+ ++ G G + ER+ + + H + + + +V + W E
Sbjct: 67 KRMRGFEAVWLPGTDHAGIATQVVVERLLLKEGKTRHDLGREKFLERVWQ---WKEESGG 123
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
I+K R G S DWSRE +T P + + F + +G + V
Sbjct: 124 TILKQLK--------RLGASADWSREAFTMDENAP---AVPYAFSRYYHEGLAYRAPRLV 172
Query: 184 RWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWI 243
W P T L D + +E E P Y +++E++ G ++ AT+RPETV+ + +
Sbjct: 173 NWCPRCETTLSDLE-VETEPTPGKLYT-LRYEVEGGG---FIEIATVRPETVFADQAIAV 227
Query: 244 NPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGD 303
+P E+ + L+GK R P+ D
Sbjct: 228 HP--------------------------------------EDERYRHLLGKRARIPILAD 249
Query: 304 EVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYIS 363
PA V+ D TG + PAH P D+ EI ++ + P +S
Sbjct: 250 -----PA--VEKDFGTGALKVTPAHDPLDY----------EIGERHGLKP--------VS 284
Query: 364 LIKLEGYGEFPAVEE 378
+I LEG E V E
Sbjct: 285 VINLEGRMEGERVPE 299
Score = 79.6 bits (193), Expect = 2e-13
Identities = 83/357 (23%), Positives = 160/357 (44%), Gaps = 36/357 (10%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAI----FREEHWPKGIAVNGFGTLE- 647
E E+ + +YP D +G D++ F + + + F E K + ++G E
Sbjct: 463 EETEDLKAFYPGDVLVTGYDIL-----FLWVSRMEVSGYHFMGERPFKTVLLHGLVLDEK 517
Query: 648 GQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE- 706
GQKMSKSKGNV++ ++ +E GAD +R ++ LA D + + R + Y
Sbjct: 518 GQKMSKSKGNVIDPLEMVERYGADALRFALIYLATGGQDIRLDLRWLEMARNFANKLYNA 577
Query: 707 ---LISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
++ ++AKE+ D+++ RL++ +E T E A + + + ++
Sbjct: 578 ARFVLLSREGFQAKEDTP-TLADRFMRTRLSRGVEEITALYEALDLAQAAREVYELVWSE 636
Query: 764 L-RWYMRRTEGRDDEAKRFVLRKLAD---IWVRLMAPFTPHICEELWEKLGGEGFVSLAK 819
WY+ + LR L + + ++L+ P P + EL++ L G+ ++L
Sbjct: 637 FCDWYLEAAKPALKAGNAHTLRTLEEVLAVLLKLLHPMMPFLTSELYQALTGKEELALEA 696
Query: 820 WPEPVDEWWNEEVEVEEDFIKSLIEDIKEIIEVAKIESPKRAYIY----TAP-EWKWKVY 874
WPEP +EE E + +K + ++ + A + + +Y TAP E +V+
Sbjct: 697 WPEPGGR--DEEAERAFEALKQAVTAVRALKAEAGLPPAQEVRVYLEGETAPVEENLEVF 754
Query: 875 EVVAEKREFKSAMAELMKDEEIRKHGKEVAKLVQAIIKERAFDVK--RIDEEKVLRE 929
++ A+L+ + + K + ++ + E DV+ R +EK L+E
Sbjct: 755 RFLSR--------ADLLPERPAKALVKAMPRVTARMPLEGLLDVEEWRRRQEKRLKE 803
>sp|Q21926|SYI_CAEEL PROBABLE ISOLEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (ISOLEUCINE--TRNA
LIGASE) (ILERS) >gi|7506619|pir||T24176 hypothetical
protein R11A8.6 - Caenorhabditis elegans
>gi|3879120|emb|CAA94369.1| (Z70310) predicted using
Genefinder~Similarity to Human isoleucyl-tRNA synthetase
(SW:SYI_HUMAN), contains similarity to Pfam domain:
PF00133 (tRNA synthetases class I (I, L, M and V)),
Score=1059.9, E-value=0, N=1~cDNA EST yk26b10.3 comes
from this ge>
Length = 1141
Score = 85.8 bits (209), Expect = 2e-15
Identities = 89/368 (24%), Positives = 156/368 (42%), Gaps = 27/368 (7%)
Query: 4 LNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
+NF E+K ++W + F+ +++ F P+ +G H GH T TI DV+
Sbjct: 11 INFAREEDKVAQKWQDENTFQRSVELSKDRPHFTFYDGPPFATGLPHYGHMLTSTIKDVV 70
Query: 64 ARFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDP 122
R+ G+ V GW G P+ I + + P +DV K+ I +
Sbjct: 71 GRWAHQNGHYVERRFGWDTHGLPVEYEIDKTLGISGP------QDVMKM--GIANYNNEC 122
Query: 123 VNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHR 182
IV + ++T R G VD+ ++ T L+P F + + W F +L +KG + KG
Sbjct: 123 RKIVMRYSGEWEKTMGRLGRWVDFKHDYKT--LYPWFMESVWWAFSELHKKGLVYKGVKV 180
Query: 183 VRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMW 242
+ + TPL + + + + V + F+L + L A T P T+ +
Sbjct: 181 MPFSTACSTPLSNFEAGQNYKDVVDPAVFVGFKLLDCPNR-QLVAWTTTPWTLPSNLALV 239
Query: 243 INPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKG--------EKLIGK 294
++P+ YV K K G E +++ +E +L ++ +EVIE+ G E L
Sbjct: 240 VHPDMLYVVTKDKTTGIE--YVVLEERLGEL--KNDNLEVIEKLAGSQLKDLRYEPLFPY 295
Query: 295 YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDH---VALEDLKRESEILVKYDI 351
+ + +L FV D+ TGVV P D VA + ++ +++ D
Sbjct: 296 FAYMREERNAFRVLNDTFVTSDSGTGVVHQAPYFGEIDFQVCVANGVIAKDQKMICPVDE 355
Query: 352 DPRIVEEI 359
+ E+
Sbjct: 356 SGKYTSEV 363
>sp|O84304|SYV_CHLTR VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437659|pir||H71532 valine--tRNA ligase (EC 6.1.1.9)
- Chlamydia trachomatis (serotype D, strain UW3/Cx)
>gi|3328717|gb|AAC67895.1| (AE001302) Valyl tRNA
Synthetase [Chlamydia trachomatis]
Length = 939
Score = 85.8 bits (209), Expect = 2e-15
Identities = 81/320 (25%), Positives = 136/320 (42%), Gaps = 59/320 (18%)
Query: 17 WLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLF 76
W + +F N + + + I + P ++G LH+GHA T+ D + R+KRMQG+ V +
Sbjct: 23 WERSGMFVANASSE--KPAYSIVMPPPNVTGILHMGHALVNTLQDTLIRYKRMQGFEVCW 80
Query: 77 PMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEI--LWTF-EDPVNIVKYFMKAA 133
G G + ER ++ R + E + +W + E N++ ++
Sbjct: 81 VPGTDHAGIATQTVVERHLKA---SLGKQRTDFSREEFLKHVWDWKEKSQNVILSQLR-- 135
Query: 134 KETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPL 193
+ G S DWSR+ +T P ++ ++ F L +KG I +G + V WDP++ T L
Sbjct: 136 -----QLGCSCDWSRQRFTMD--PGANRAVKKAFKILFDKGVIYRGYYLVNWDPILQTAL 188
Query: 194 GDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAK 253
D ++ E L Y I++++ +E ++ AT RPET+ G T + ++P
Sbjct: 189 ADDEVEYEERDGWLYY--IRYQVVNSEE--FITVATTRPETLLGDTAIAVSP-------- 236
Query: 254 VKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEFV 313
E+ + LIG V P E+ I+ V
Sbjct: 237 ------------------------------EDLRYSHLIGAKVVVPFVNREIPIIGDFSV 266
Query: 314 DPDNATGVVMSVPAHAPFDH 333
D TG V PAH D+
Sbjct: 267 DASFGTGAVKITPAHDKDDY 286
>gi|6325217 nuclear encoded mitochondrial isoleucyl-tRNA synthetase; Ism1p
[Saccharomyces cerevisiae]
>gi|1711634|sp|P48526|SYIM_YEAST ISOLEUCYL-TRNA
SYNTHETASE, MITOCHONDRIAL (ISOLEUCINE--TRNA LIGASE)
(ILERS) >gi|2132320|pir||S62035 isoleucine--tRNA ligase
(EC 6.1.1.5), mitochondrial - yeast (Saccharomyces
cerevisiae) >gi|1171418|gb|AAB68180.1| (U44030) Ism1p:
mitochondrial isoleucyl-tRNA synthetase [Saccharomyces
cerevisiae]
Length = 1002
Score = 85.0 bits (207), Expect = 4e-15
Identities = 173/880 (19%), Positives = 331/880 (36%), Gaps = 140/880 (15%)
Query: 32 KEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIA 91
KEK F + PY +G LH+GHA + D+I R++ QG + + GW G PI
Sbjct: 83 KEKLFILHDGPPYANGELHLGHALNKILKDIINRYQLSQGKYIFYKPGWDCHGLPI---- 138
Query: 92 ERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYFMKAAK---ETFIRAGFSVDWSR 148
I +D+ E + + +K+ KA K ETF DW
Sbjct: 139 ---------EIKALKDLSAQQIESISPLKIRSMALKHAQKAIKRQRETFQHFAILTDWET 189
Query: 149 EFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGED-VPIL 207
+ T ++ F ++ E+G I + V W T L + +L E+ I
Sbjct: 190 PYLTMDKDYEINQLN--IFKEMYERGLIKRQNKPVYWGTETRTALAEGELEYNENHKSIA 247
Query: 208 EYVIIKFELKE-----------GDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKR 256
YV E K + IY T P T+ + N + +Y ++
Sbjct: 248 AYVKFPLEKKSQMDLCKKLGITNNLPIYCLIWTSTPWTLLSNRAICFNQDFSYSLLRL-- 305
Query: 257 GGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEV--IILPAEFVD 314
E ++ + KL E I++F+G L G Y +N + D+V +L V
Sbjct: 306 --NSELILVETGSIDKLGLTTNSFETIKQFQGTHLNGLYYQNLLVDDKVGRPLLHGAHVT 363
Query: 315 PDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEFP 374
TG+V + P H D++ I + S + +G +
Sbjct: 364 SGTGTGLVHTAPGHGQDDYLI------------------GIQNGLEIYSPVDHQGRYQLN 405
Query: 375 AVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQEVKELIAKEMMEK 434
+ + + ++ + D K Q E ++I ++ +
Sbjct: 406 ELPQSVRSIVRDEGDLTKGRQVLDA----------------------ETAKIILCKLSDL 443
Query: 435 GIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALARMKIYPETRRA 494
+ +E+ + VI QWF D + K A ++++R+K P+ +
Sbjct: 444 NLLYKSHEYTHSYPYDWRSKKPVIIRATPQWFADL--HDVKNLALESISRVKFCPKRGYS 501
Query: 495 QFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTISRHINRLREEG-- 552
+ + + ++ +R+ G P+ + +S DS + M ++ I +++++G
Sbjct: 502 RLSSFMKSRNEWCISRQRSWGIPI---LSFYKKSEPDS-VLMNSEILAHAIEKIKQKGIN 557
Query: 553 ------RLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEE----FEYWY 602
D ++ PE + + E + ++ +G +I + E+ +
Sbjct: 558 AWFNDKDNDMKEWLPEKYHDVAHEYCRSQDTMDVWFDSGSSWSVIKDFYEKSLKLSKLPS 617
Query: 603 PLDWRC-SGKDLIPNHLTFFIFNHVAIFREEHWP-KGIAVNGFGTLE--GQKMSKSKGNV 658
PL C G D + VA P + + +GF TL+ G KMSKS GN
Sbjct: 618 PLYQVCLEGSDQHRGWFQSSLLTKVASSNVPVAPYEEVITHGF-TLDENGLKMSKSVGNT 676
Query: 659 LN--FIDAIEEN------GADVVRLYIMSLAEHDSDF---DWRRKEVG----KLRRQLER 703
++ I +EN G D +R Y+++ + +D K VG K+R
Sbjct: 677 ISPEAIIRGDENLGLPALGVDGLR-YLIAQSNFTTDIVAGPTVMKHVGEALKKVRLTFRY 735
Query: 704 FYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
+ + ++ +L+ +D++ L+++N+ +E T + +++ + Y + N+
Sbjct: 736 LLSNLQKSQDFNLLPIEQLRRVDQYTLYKINELLETTREHYQKYNFSKVLITLQYHLNNE 795
Query: 764 LR----------WYMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEK----- 808
L Y + + L + + + ++AP P + +E+W+
Sbjct: 796 LSAFYFDISKDILYSNQISSLARRQVQTTLVHILNAYRAILAPILPVMVQEVWKYIPEGW 855
Query: 809 LGGEGFVSL----AKWP------EPVDEWWNEEVEVEEDF 838
L G+ + + KWP E V + N E+++ + F
Sbjct: 856 LQGQEHIDINPMRGKWPFLDSNTEIVTSFENFELKILKQF 895
>sp|P75398|SYL_MYCPN LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|2146327|pir||S73779 leucine--tRNA ligase (EC
6.1.1.4) leuS - Mycoplasma pneumoniae (strain ATCC
29342) >gi|1674141|gb|AAB96101.1| (AE000044) leucyl-tRNA
synthetase [Mycoplasma pneumoniae]
Length = 793
Score = 85.0 bits (207), Expect = 4e-15
Identities = 109/467 (23%), Positives = 180/467 (38%), Gaps = 104/467 (22%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGH-LHVGHARTYTIPDVI 63
N +EEKW + W + K DK K K +YI FPY S LH+GH R YTI DV+
Sbjct: 3 NHNLLEEKWLQLW-KTKQVNRFFDDKTKPK-YYILDMFPYPSAAGLHLGHVRAYTITDVL 60
Query: 64 ARFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
+R+ + +G+NV+ P+G+ G P A N+ P WT ++
Sbjct: 61 SRYHKAKGFNVIHPIGFDAFGLPAEQYA-IASNKHPGD---------------WTDKNIT 104
Query: 124 NIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRV 183
N + E GF D+ TT P + ++ +W F +L E G V
Sbjct: 105 NFI--------EQLTAFGFDYDYQLSLKTTD--PRYYQYTQWIFGQLFEAGLAEVKEIDV 154
Query: 184 RWDPVVGTPLGDHDLM---------EGEDVPIL--------------------------- 207
W +GT L + +++ E + P+
Sbjct: 155 NWCAELGTVLANEEVLIDSNGNAVSERGEFPVTKRKMKQWVLKITAFAESLLNGLAELDW 214
Query: 208 ---------------EYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKA 252
E V + F+++ ETI + T + +T++GVT + ++ + VK
Sbjct: 215 HQSIKEMQTNWIGKSEGVEVTFDIENSKETITI--FTTKVQTIFGVTFLALSNSHPLVKE 272
Query: 253 KVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVIILPAEF 312
K K + + K+A + ++ E + + KL NP T + + A +
Sbjct: 273 VAKTNPKIAQF-LQKQAQKTTTV--KQPETLHDGVDLKL---KAINPATNTAIPLYVANY 326
Query: 313 VDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGE 372
V T VM VPAH D+ K++ I+ D R+ + G
Sbjct: 327 VVEGYGTDAVMGVPAHNENDNFFAR--KQKLPIITVIDKQERLQHSGQF------SGLNS 378
Query: 373 FPAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKP 419
A ++ ++ ++ QK ++ T+YK IF Y G+P
Sbjct: 379 QTANTQITQMLVERQKAKK------TTVYK--LRDWIFSRQRYWGEP 417
Score = 72.6 bits (175), Expect = 2e-11
Identities = 62/235 (26%), Positives = 108/235 (45%), Gaps = 26/235 (11%)
Query: 593 EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFRE------EHWPKGIAVNGFGTL 646
E K+ FE + P+D G + HL + F H ++++ E + K I
Sbjct: 506 EAKDLFERYLPVDLYVGGAEHAVLHLLYARFWHQFLYQKGIVTTKEPFKKLINQGMVLGP 565
Query: 647 EGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE 706
+G+KMSKSKGN +N I+ +GAD +RLY+M + + W + +RR L+R +
Sbjct: 566 DGKKMSKSKGNTINPTPLIDSHGADALRLYLMFMGPISAALTWLDDGLNGMRRWLDRVHN 625
Query: 707 LISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW 766
KEN+ +T+D+ ++ N ++ + + LE+ + +M L
Sbjct: 626 FFH-------KENIIKETVDQETVYGYNLFLKRSFEHLEKQELNLVIS----QMMIFLNL 674
Query: 767 YMRRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
+ + AK F + +++ F P++ EEL KLG E F+ A+ P
Sbjct: 675 LYKTKQLTLAYAKGF---------LTVLSFFAPYLAEELNAKLGMEPFIVHAQLP 720
>gb|AAA64890.1| (L38957) mitochondrial isoleucyl-tRNA synthetase [Saccharomyces
cerevisiae]
Length = 1002
Score = 83.9 bits (204), Expect = 8e-15
Identities = 177/880 (20%), Positives = 335/880 (37%), Gaps = 140/880 (15%)
Query: 32 KEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIA 91
KEK F + PY +G LH+GHA + D+I R++ QG + + GW G PI
Sbjct: 83 KEKLFILHDGPPYANGELHLGHALNKILKDIINRYQLSQGKYIFYKPGWDCHGLPI---- 138
Query: 92 ERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYFMKAAK---ETFIRAGFSVDWSR 148
I +D+ E + + +K+ KA K ETF DW
Sbjct: 139 ---------EIKALKDLSAQQIESISPLKIRSMALKHAQKAIKRQRETFQHFAILTDWET 189
Query: 149 EFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGED-VPIL 207
+ T ++ F ++ E+G I + V W T L + +L E+ I
Sbjct: 190 PYLTMDKDYEINQLN--IFKEMYERGLIKRQNKPVYWGTETRTALAEGELEYNENHKSIA 247
Query: 208 EYVIIKFELKE-----------GDETIYLPAATLRPETVYGVTNMWINPNATYVKAKVKR 256
YV E K + IY T P T+ + N + +Y ++
Sbjct: 248 AYVKFPLEKKSQMDLCKKLGITNNLPIYCLIWTSTPWTLLSNRAICFNQDFSYSLLRL-- 305
Query: 257 GGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEV--IILPAEFVD 314
E ++ + KL E I++F+G L G Y +N + D+V +L V
Sbjct: 306 --NSELILVETGSIDKLGLTTNSFETIKQFQGTHLNGLYYQNLLVDDKVGRPLLHGAHVT 363
Query: 315 PDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEFP 374
TG+V + P H D++ I + S + +G +
Sbjct: 364 SGTGTGLVHTAPGHGQDDYLI------------------GIQNGLEIYSPVDHQGRYQLN 405
Query: 375 AVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQEVKELIAKEMMEK 434
+ + + ++ + D K Q E ++I ++ +
Sbjct: 406 ELPQSVRSIVRDEGDLTKGRQVLDA----------------------ETAKIIPCKLSDL 443
Query: 435 GIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALARMKIYPETRRA 494
+ +E+ + VI QWF D + K A ++++R+K P+ +
Sbjct: 444 NLLYKSHEYTHSYPYDWRSKKPVIIRATPQWFADL--HDVKNLALESISRVKFCPKRGYS 501
Query: 495 QFEAIIDWLDKKACARKVGLGTPLPWDPEWVIESLSDSTIYMAYYTISRHINRLREEG-- 552
+ + + ++ +R+ G P+ + +S DS + M ++ I +++++G
Sbjct: 502 RLSSFMKSRNEWCISRQRSWGIPI---LSFYKKSEPDS-VLMNSEILAHAIEKIKQKGIN 557
Query: 553 ------RLDPEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEE----FEYWY 602
D ++ PE + + E + ++ +G +I + E+ +
Sbjct: 558 AWFNDKDNDMKEWLPEKYHDVAHEYCRSQDTMDVWFDSGSSWSVIKDFYEKSLKLSKLPS 617
Query: 603 PLDWRC-SGKDLIPNHLTFFIFNHVAIFREEHWP-KGIAVNGFGTLE--GQKMSKSKGNV 658
PL C G D + VA P + + +GF TL+ G KMSK GN
Sbjct: 618 PLYQVCLEGSDQHRGWFQSSLLTKVASSNVPVAPYEEVITHGF-TLDENGLKMSKLVGNT 676
Query: 659 LN--FIDAIEEN------GADVVRLYIMSLAEHDSDF---DWRRKEVG----KLRRQLER 703
++ I +EN G D +R Y+++ + +D K VG K+R
Sbjct: 677 ISPEAIIRGDENLGLPALGVDGLR-YLIAQSNFTTDIVAGPTVMKHVGEALKKVRLTFRY 735
Query: 704 FYELISQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMND 763
+ + ++ +L+ +D++ L+++N+ +E T + +++ + Y + N+
Sbjct: 736 LLSNLQKSQDFNLLPIEQLRRVDQYTLYKINELLETTREHYQKYNFSKVLITLQYHLNNE 795
Query: 764 L-RWYMRRTEG------RDDEAKRFVLRKLADI---WVRLMAPFTPHICEELWEK----- 808
L +Y ++G A+R V L I + ++AP P + +E+W+
Sbjct: 796 LSAFYFDISKGILYSNQISSLARRQVQTTLVHILNAYRAILAPILPVMVQEVWKYIPEGW 855
Query: 809 LGGEGFVSL----AKWP------EPVDEWWNEEVEVEEDF 838
L G+ + + KWP E V + N E+++ + F
Sbjct: 856 LQGQEHIDINPMRGKWPFLDSNTEIVTSFENFELKILKQF 895
>pir||E75407 isoleucyl-tRNA synthetase - Deinococcus radiodurans (strain R1)
>gi|6459088|gb|AAF10907.1|AE001980_2 (AE001980)
isoleucyl-tRNA synthetase [Deinococcus radiodurans]
Length = 1078
Score = 83.5 bits (203), Expect = 1e-14
Identities = 68/268 (25%), Positives = 116/268 (42%), Gaps = 20/268 (7%)
Query: 596 EEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKMSKSK 655
E+F YP D+ C D ++ + + I + +G KMSKSK
Sbjct: 583 EQFAKHYPADYICEAIDQTRGWFYSLHAISTMLYDQPAYKNVICLGHIVDEKGLKMSKSK 642
Query: 656 GNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQ-LERFYELISQFAEY 714
GNV+ + ++ GAD VR Y+ ++ + + V + +R + + + S F Y
Sbjct: 643 GNVVAPLPLFDQYGADSVRWYMFMASDPGDQKRFSERLVAEAQRSYVNTLWNVYSFFVLY 702
Query: 715 EAKENVELKT---------IDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL- 764
+ +L +D+WLL RL + + T ALE + R+ + A ++DL
Sbjct: 703 ANLDQPDLAAAPAVAERPEMDRWLLARLEETVRDVTAALESYDARSGGR-ALEGFVDDLS 761
Query: 765 RWYMRRTE-------GRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGG-EGFVS 816
WY+RR+ G D A L + + +L APFTP + + L+ L G E V
Sbjct: 762 NWYVRRSRSRFWGEGGTVDTAAYATLHEALLVVSQLTAPFTPFLADALYRNLSGEESSVH 821
Query: 817 LAKWPEPVDEWWNEEVEVEEDFIKSLIE 844
L WP E + ++ + + ++E
Sbjct: 822 LTPWPTVRAERLDRKLTADMAAVMKVVE 849
>sp|P41368|SYIP_STAAU ISOLEUCYL-TRNA SYNTHETASE, MUPIROCIN RESISTANT (ISOLEUCINE--TRNA
LIGASE) (ILERS) (MUPIROCIN RESISTANCE PROTEIN)
>gi|581558|emb|CAA53189.1| (X75439) isoleucyl tRNA
synthetase [Staphylococcus aureus]
Length = 1024
Score = 83.1 bits (202), Expect = 1e-14
Identities = 85/339 (25%), Positives = 148/339 (43%), Gaps = 32/339 (9%)
Query: 17 WLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLF 76
W K+F+ +I ++ ++ F P +G H GH I D++AR K MQG+ V
Sbjct: 16 WNTQKIFKKSIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVER 75
Query: 77 PMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYFMKAAKE 135
GW G P+ + + ++I + I + Y + I + N K + +K+
Sbjct: 76 KAGWDTHGLPVELEVEKKIGIKGKQDI----EKYGIENFINECKKSVFNYEKEWRDFSKD 131
Query: 136 TFIRAGFSVDWSREFYTTSLFPPFSKFIE--WQFLK-LKEKGYIVKGAHRVRWDPVVGTP 192
G+ VD + T + +IE W L +KG + KG + T
Sbjct: 132 ----LGYWVDMDSPYITLE-----NNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQTA 182
Query: 193 LGDHDLMEG-EDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVK 251
L H++ +G ++V L ++KF+L +T +L + T P T+ + IN + Y K
Sbjct: 183 LSSHEVAQGYKNVKDLS-AVVKFQLTNSKDTYFL-SWTTTPWTLPANVALAINKDLNYSK 240
Query: 252 AKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVI----I 307
+V + E +I++ + S + E+I+ F G LI P D ++ +
Sbjct: 241 IRV----ENEYYILATDLIN--SIITEKYEIIDTFSGSNLINLKYIPPFESDGLVNAYYV 294
Query: 308 LPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEIL 346
+ EFV TG+V PAH D+ + L+R+ + L
Sbjct: 295 VDGEFVTNSEGTGIVHIAPAHGEDDYQLV--LERDLDFL 331
>pir||T38777 probable valyl trna synthetase - fission yeast
(Schizosaccharomyces pombe) >gi|4490646|emb|CAB38577.1|
(Z98762) putative valyl trna synthetase
[Schizosaccharomyces pombe]
Length = 950
Score = 82.3 bits (200), Expect = 2e-14
Identities = 197/1008 (19%), Positives = 379/1008 (37%), Gaps = 253/1008 (25%)
Query: 30 KPKEKK---FYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGSP 86
KPK + F I + P ++G LH+GHA T TI D +ARF M GY V F G G
Sbjct: 51 KPKSIEAPMFPILLPPPNITGKLHIGHALTITIQDALARFYAMHGYKVSFRPGTDHAGIA 110
Query: 87 IVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYFMKAAKETFIRAGFSVDW 146
+ E+ + +YR+ E + V K + K A F DW
Sbjct: 111 TQSVVEKYLQKK----GVYRNQLSKDELLSSIHSWQVKYQKSIINQLKS--FEAIF--DW 162
Query: 147 SREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGE-DVP 205
FYT + S+ + F+ L G I + V W P + + + D ++ + + P
Sbjct: 163 DNIFYT--MDQNRSEAVNEAFISLFNAGLIYRANRFVNWCPKLESAVSDIEVESQQINKP 220
Query: 206 ILEYV-----------IIKFELKEGDETIYLPAATLRPETVYGVTNMWINPNATYVKAKV 254
+ +YV I ++L EG + L +T RPET++G + ++P+
Sbjct: 221 VTKYVDNTPVEFGWLYEISYQL-EGSDNEQLNVSTTRPETIFGDRAIAVSPH-------- 271
Query: 255 KRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEVI-ILPAEFV 313
+ YK K +G++V++P+ D +I ++ V
Sbjct: 272 -------------DERYK-----------------KYVGRFVKHPLIDDLLIPVICDNAV 301
Query: 314 DPDNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEF 373
D TGV+ P H+ D+ EI +++ID +S++ G
Sbjct: 302 DRHFGTGVLKITPMHSIVDY----------EIAKRHNID--------CVSIMDKSG-NLI 342
Query: 374 PAVEEVQKLGIKSQKDREKLEQATKTIYKAEYHKGIFKVPPYDGKPVQEVKELIAKEMME 433
+EV G+ K R K I ++ + V++V +
Sbjct: 343 NCSKEVN--GMNRLKARSK----------------IVRLLQQRNRLVEQVPHSLI----- 379
Query: 434 KGIAEIMYEFAEKNVISRFGNRAVIKIIHDQWFIDYGNSEWKEKARKALARMKIYPETRR 493
+V SR G+ + ++ QW++ K++ K+ ++K+ P R
Sbjct: 380 ------------LSVCSRTGD-VIEPVMVPQWYLSV--DSLKKEVLKSSNKLKLVPSLAR 424
Query: 494 AQFEAIIDWLDKKACARKVGLGTPLP-W----DPEWVIESLSDSTIYMAYYTISRHINRL 548
++++ + +R++ G +P W + +W+ + + + ++ + +++
Sbjct: 425 KEWDSWFKKMGDWCISRQIWWGHQIPVWKILEEDKWIAAPNYEKALQL---SVGKSVSQ- 480
Query: 549 REEGRLDPEKLTPEFFDYIF-LEEFSEEREKELEKKTGIPAEIIHEMKEEFEYWYPLDWR 607
D + L F + L F + K+++ PL +
Sbjct: 481 ------DSDVLDTWFSSALLPLSAFGWPKSKDIQ---------------------PLPFI 513
Query: 608 CSGKDLIPNHLTFFIFNHVAI----FREEHWPKGIAVNGF-GTLEGQKMSKSKGNVLN-- 660
SG+D++ FF +A+ F E K I ++ EG+KMSKS GNV++
Sbjct: 514 ESGQDIL-----FFWIARMALLCKYFSNELPFKEIILHPLVRDSEGRKMSKSLGNVIDPM 568
Query: 661 -----------------------------------FIDAIEENGADVVRLYIMSLAEHDS 685
F + I G D+ R + H+
Sbjct: 569 DIINGVTLENMKKALLEGNLPISEVHKSSKQMEKAFPNGIPAQGIDIFRYGLFLCLHHEQ 628
Query: 686 DFDWRRKEVGKLRRQLERFYELISQFAEYEAKENVELKTIDKW----------LLHRLNK 735
R + + + L F +Y+ KEN LK D +L+
Sbjct: 629 RILLDMNSFSDAHRFVSKLWNLARYFNQYKDKEN-PLKLTDSQRQRISLLKMATYSKLHH 687
Query: 736 AIEGTTKALEEFRTRTAVQWAFYSIMNDLRWY---MRRTEGRDDEAKRF----VLRKLAD 788
A+EG ++ E+ + A ++NDL + R + +D ++ + V +
Sbjct: 688 AVEGVKESFEQRKFFNAADIMKNFLLNDLSSVYVELTRFDVKDSKSSAYEVYRVFSDILH 747
Query: 789 IWVRLMAPFTPHIC-----EELWEKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLI 843
I+++L+ P P I ++ + F+S P + E + V ++ + ++
Sbjct: 748 IFLKLIHPIVPCISGVMLHSKIIPERKNSEFLSF-----PTSQ--QECLLVHDNQAEVVV 800
Query: 844 EDIKEI-IEVAKIESP--------KRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDE 894
++ ++ I++ K+ESP YI T+ E Y+ + + K
Sbjct: 801 QNAYDVLIQLRKLESPLNKSPSREHTVYISTSLEPLKYFYDAIEQSTNLKLKSISQEDTI 860
Query: 895 EIRKHGKEVAKLVQA----IIKERAFDVKRIDEEKVLRESKDFLEKEL 938
++ ++ + + + ++ ++ + KR K LR++ D L+K+L
Sbjct: 861 DLMRNQTFILSRISSDTILLVPKKLYPSKR----KKLRKNLDDLQKKL 904
>gb|AAF63175.1|AC010657_11 (AC010657) T5E21.11 [Arabidopsis thaliana]
Length = 1115
Score = 82.3 bits (200), Expect = 2e-14
Identities = 92/351 (26%), Positives = 145/351 (41%), Gaps = 83/351 (23%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP-------D 61
+E+ W W ++ +F+ + K + F I + P ++G LH+GHA T I D
Sbjct: 145 VEKSWYAWWEKSDLFKADAKSS--KPPFVIVLPPPNVTGALHIGHALTSAIEVSLAYCLD 202
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAER--IKNRDPHTIWIYRDVYKVPEEILWTF 119
I R+KRM GYN L+ G G + E+ +++R + R+ + V E W
Sbjct: 203 TIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKIMRDRGMTRHDVGREEF-VKEVWKWKN 261
Query: 120 EDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKG 179
+ I+ R G S+DWSRE +T SK + F++L ++G I +
Sbjct: 262 QYGGTILTQLR--------RLGASLDWSRECFTMD--EQRSKAVTEAFVRLYKEGLIYRD 311
Query: 180 AHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIK-----------------FELKEGDET 222
V WD ++ T + D +E E + I E ++K + L+ G
Sbjct: 312 IRLVNWDCILRTAISD---VEVEYIDIKEKTLLKVPGYEKPVEFGLLTSFAYPLEGGLGE 368
Query: 223 IYLPAATLRPETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEV 282
+ + AT R ET+ G T + I+P+ +A YK
Sbjct: 369 VIV--ATTRVETMLGDTAIAIHPD---------------------DARYK---------- 395
Query: 283 IEEFKGEKLIGKYVRNPVTGDEV-IILPAEFVDPDNATGVVMSVPAHAPFD 332
L GK+ +P G ++ II VDP+ TG V PAH P D
Sbjct: 396 -------HLHGKFAVHPFNGRKLPIICDGILVDPNFGTGCVKITPAHDPND 439
>pir||T34946 probable isoleucyl-tRNA synthetase - Streptomyces coelicolor
>gi|5689948|emb|CAB51985.1| (AL109663) putative
isoleucyl-tRNA synthetase [Streptomyces coelicolor
A3(2)]
Length = 1047
Score = 81.9 bits (199), Expect = 3e-14
Identities = 66/278 (23%), Positives = 120/278 (42%), Gaps = 30/278 (10%)
Query: 592 HEMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVAIFREEHWPKGIAVNGFGTLEGQKM 651
++ KE FE YP + D + +F + + + + +G+KM
Sbjct: 542 YKNKELFESRYPAQFISEAIDQTRGWFYTLMAVGTLVFDKSSYENVVCLGHILAEDGRKM 601
Query: 652 SKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGK------LRRQLERFY 705
SK GN+L I ++++GAD VR ++ + W + VG +R+ L ++
Sbjct: 602 SKHLGNILQPIPLMDQHGADAVRWFMAA-----GGSPWAARRVGHGTIQEVVRKTLLTYW 656
Query: 706 ELISQFAEYEAKEN----------VELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQW 755
++ A Y + +D+WLL L+ + T+AL+ + T+ A +
Sbjct: 657 NTVAFQALYARTTGWAPSEADPAPADRPVLDRWLLSELHALTDQVTQALDAYDTQRAGKL 716
Query: 756 AFYSIMNDLRWYMRRTEGR---DDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKL--- 809
+ + WY+RR+ R D+A L ++ + +LMAP TP I E +W+ L
Sbjct: 717 LSAFVDDLSNWYVRRSRRRFWQGDKAALRTLHEVVETVTKLMAPLTPFITERVWQDLVVP 776
Query: 810 ---GGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIE 844
G V L+ WPE + E+ + ++ L+E
Sbjct: 777 VTPGAPESVHLSSWPEADLTAIDPELSKQMVLVRRLVE 814
Score = 71.0 bits (171), Expect = 6e-11
Identities = 76/338 (22%), Positives = 133/338 (38%), Gaps = 23/338 (6%)
Query: 3 ELNFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
+++ A+E W E K+F +++ ++ P +G H DV
Sbjct: 12 QVDLPALEHAVLDFWREQKIFAKSLEQSEGRPEWVFYEGPPTANGMPGAHHIEARVFKDV 71
Query: 63 IARFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFED 121
RF+ M+GY+V GW G P+ + + + + I + Y + E E
Sbjct: 72 FPRFRTMRGYHVGRKAGWDCHGLPVELAVEKELGFSGKQDI----EAYGIAEFNAKCRES 127
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAH 181
V A +E R G+ D + T P + + + W ++ KG +V+
Sbjct: 128 ----VTRHTDAFEELTTRMGYWADLQDPYRTMD--PEYIESVWWSLKEIFNKGLLVQDHR 181
Query: 182 RVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGD--ETIYLPAATLRPETVYGVT 239
W P GT L DH+L +G + + V ++F L G L T P T+ T
Sbjct: 182 VAPWCPRCGTGLSDHELAQGYETVVDPSVYVRFPLTSGPLAGEAALVVWTTTPWTLVSNT 241
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
+ +P+ TYV A EE ++++ K + E + F G ++ + P
Sbjct: 242 AVAAHPDVTYVVAT----DGEEKLVVAEPLLAKALGEGWE-TTGQSFTGAEMERWTYQRP 296
Query: 300 VTGDEV-----IILPAEFVDPDNATGVVMSVPAHAPFD 332
E ++ A++V ++ TG+V PA D
Sbjct: 297 FELVEFPEPAHYVVNADYVTTEDGTGLVHQSPAFGEDD 334
>pdb|1FFY|A Chain A, Insights Into Editing From An Ile-Trna Synthetase
Structure With Trna(Ile) And Mupirocin
>gi|6137708|pdb|1QU2|A Chain A, Insights Into Editing
From An Ile-Trna Synthetase Structure With Trna(Ile) And
Mupirocin >gi|6137710|pdb|1QU3|A Chain A, Insights Into
Editing From An Ile-Trna Synthetase Structure With
Trna(Ile) And Mupirocin
Length = 917
Score = 81.5 bits (198), Expect = 4e-14
Identities = 79/329 (24%), Positives = 133/329 (40%), Gaps = 22/329 (6%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
I+EKW K E N + F + PY +G+LH+GHA + D I R+K
Sbjct: 27 IQEKWDAEDQYHKALEKN----KGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKT 82
Query: 69 MQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
MQG+ + GW G PI + ++ +R + +R+ K E L E
Sbjct: 83 MQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEFRE--KCKEFALEQIE------- 133
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
K+ F R G D++ + T L P + F ++ +KG I KG V W P
Sbjct: 134 ----LQKKDFRRLGVRGDFNDPYIT--LKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSP 187
Query: 188 VVGTPLGDHDLMEGEDVPILEYVIIKFELKEG--DETIYLPAATLRPETVYGVTNMWINP 245
+ L + ++ + YV + +G D T P T+ + ++P
Sbjct: 188 SSESSLAEAEIEYHDKRSASIYVAFNVKDDKGVVDADAKFIIWTTTPWTIPSNVAITVHP 247
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEV 305
Y + V +S A L + I++ +E+ G++L ++P E
Sbjct: 248 ELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEWVVAQHPFLDRES 307
Query: 306 IILPAEFVDPDNATGVVMSVPAHAPFDHV 334
+++ + V D TG V + P H D++
Sbjct: 308 LVINGDHVTTDAGTGCVHTAPGHGEDDYI 336
>sp|P41972|SYI_STAAU ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|541337|pir||S40178 isoleucine--tRNA ligase (EC
6.1.1.5) - Staphylococcus aureus
>gi|437916|emb|CAA52296.1| (X74219) isoleucyl-tRNA
synthetase [Staphylococcus aureus]
Length = 917
Score = 81.1 bits (197), Expect = 5e-14
Identities = 79/329 (24%), Positives = 133/329 (40%), Gaps = 22/329 (6%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
I+EKW K E N + F + PY +G+LH+GHA + D I R+K
Sbjct: 27 IQEKWDAEDQYHKALEKN----KGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKT 82
Query: 69 MQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVK 127
MQG+ + GW G PI + ++ +R + +R+ K E L E
Sbjct: 83 MQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEFRE--KCKEFALEQIE------- 133
Query: 128 YFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDP 187
K+ F R G D++ + T L P + F ++ +KG I KG V W P
Sbjct: 134 ----LQKKDFRRLGVRGDFNDPYIT--LKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSP 187
Query: 188 VVGTPLGDHDLMEGEDVPILEYVIIKFELKEG--DETIYLPAATLRPETVYGVTNMWINP 245
+ L + ++ + YV + +G D T P T+ + ++P
Sbjct: 188 SSESSLAEAEIEYHDKRSASIYVAFNVKDDKGVVDADAKFIIWTTTPWTIPSNVAITVHP 247
Query: 246 NATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVTGDEV 305
Y + V +S A L + I++ +E+ G++L ++P E
Sbjct: 248 ELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEYVVAQHPFLDRES 307
Query: 306 IILPAEFVDPDNATGVVMSVPAHAPFDHV 334
+++ + V D TG V + P H D++
Sbjct: 308 LVINGDHVTTDAGTGCVHTAPGHGEDDYI 336
>sp|Q9ZK61|SYV_HELPJ VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437644|pir||E71852 valine--tRNA ligase (EC 6.1.1.9)
- Helicobacter pylori (strain J99)
>gi|4155674|gb|AAD06660.1| (AE001535) VALYL-TRNA
SYNTHETASE [Helicobacter pylori J99]
Length = 872
Score = 81.1 bits (197), Expect = 5e-14
Identities = 70/251 (27%), Positives = 114/251 (44%), Gaps = 38/251 (15%)
Query: 13 WQKRWLEAKVFE-----------PNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPD 61
+Q +E K++E N K + K K+F + + P ++G LH+GHA T ++ D
Sbjct: 8 YQPEEIEKKIYEICSHRGYFEINGNEKIQEKGKRFCLMMPPPNVTGILHIGHALTLSLQD 67
Query: 62 VIARFKRMQGYNVLFPMGWHITGSPIVGIAER------IKNRDPHTIWIYRDVYKVPEEI 115
++ R+KRM GY L+ G G + E+ +K D + + + KV
Sbjct: 68 ILVRYKRMDGYKTLYQPGLDHAGIATQNVVEKQLLSQGVKKED---LGREKFIQKV---- 120
Query: 116 LWTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGY 175
W +++ A E R G S +SR +T + + ++ FLK EKG
Sbjct: 121 -WEWKEKSG------GAILEQMKRLGVSTAFSRTRFT--MDKGLQRAVKLAFLKWYEKGL 171
Query: 176 IVKGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETV 235
IV+ + V W G L D ++ E L Y+ E ++ YL AT RPET+
Sbjct: 172 IVQDNYMVNWCTKDGA-LSDIEVEYEERKGALYYIRYYLE----NQKDYLVVATTRPETL 226
Query: 236 YGVTNMWINPN 246
+G + + +NPN
Sbjct: 227 FGDSAIMVNPN 237
>sp|P56000|SYV_HELPY VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)
>gi|7437645|pir||A64664 valine--tRNA ligase (EC 6.1.1.9)
- Helicobacter pylori (strain 26695)
>gi|2314306|gb|AAD08195.1| (AE000621) valyl-tRNA
synthetase (valS) [Helicobacter pylori 26695]
Length = 874
Score = 80.8 bits (196), Expect = 7e-14
Identities = 64/221 (28%), Positives = 101/221 (44%), Gaps = 27/221 (12%)
Query: 32 KEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIA 91
K K+F + + P ++G LH+GHA T ++ D++AR+KRM GY L+ G G +
Sbjct: 40 KNKRFCLMMPPPNVTGVLHIGHALTLSLQDILARYKRMDGYKTLYQPGLDHAGIATQNVV 99
Query: 92 ER------IKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYFMKAAKETFIRAGFSVD 145
E+ IK D + V++ E+ A E R G S
Sbjct: 100 EKQLLSQGIKKEDLGREEFIKKVWEWKEK--------------SGGAILEQMKRLGVSAA 145
Query: 146 WSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVVGTPLGDHDLMEGEDVP 205
+SR +T + + ++ FLK EKG I++ + V W G L D ++ E
Sbjct: 146 FSRTRFT--MDKGLQRAVKLAFLKWYEKGLIIQDNYMVNWCTKDGA-LSDIEVEYEERKG 202
Query: 206 ILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPN 246
L Y+ E ++ YL AT RPET++G + + +NPN
Sbjct: 203 ALYYIRYYLE----NQKDYLVVATTRPETLFGDSALMVNPN 239
>pir||E82913 valyl-tRNA synthetase UU267 [imported] - Ureaplasma urealyticum
>gi|6899238|gb|AAF30676.1|AE002123_9 (AE002123)
valyl-tRNA synthetase [Ureaplasma urealyticum]
Length = 874
Score = 80.0 bits (194), Expect = 1e-13
Identities = 75/330 (22%), Positives = 138/330 (41%), Gaps = 65/330 (19%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+F+ +E W E +F+ I +K F I + P ++GHLH+GHA +T+ D++
Sbjct: 10 SFKEVEANKLLFWQENNLFKAQINST--KKPFTIVLPPPNVTGHLHIGHAYDFTLSDILM 67
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEI------LWT 118
R+K+++GY+ + I G+ GIA + K + + + + E+ +W
Sbjct: 68 RYKKLKGYD-----SFIIPGTDHAGIATQTKFEKNLKVNAQTNRFNLGRELFLEKLKIWK 122
Query: 119 FEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVK 178
E + Y K + G +D+S +T L P + + F+K+ + I +
Sbjct: 123 DEQ----INYIHK----QWNALGLGLDYSNYLFT--LDPIVVQTVREVFVKMFNEHIIYR 172
Query: 179 GAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVYGV 238
V WD + T + + +++ E L Y+ + D+ ++ AT RPET++G
Sbjct: 173 DKKLVNWDIQLKTAISNIEVIHKEVEQKLYYI----KYLSQDQKDFVVVATSRPETMFGD 228
Query: 239 TNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRN 298
+ INP K+ Y L K N
Sbjct: 229 KYLVINP---------------------KDKRY-----------------FHLHNKIFIN 250
Query: 299 PVTGDEVIILPAEFVDPDNATGVVMSVPAH 328
P+ E+ ++ +++D + TGV+ PAH
Sbjct: 251 PINNIEMTVILDDYIDIEFGTGVMKCTPAH 280
>gb|AAG20324.1| (AE005106) isoleucyl-tRNA synthetase; IleS [Halobacterium sp.
NRC-1]
Length = 1070
Score = 79.2 bits (192), Expect = 2e-13
Identities = 102/469 (21%), Positives = 194/469 (40%), Gaps = 61/469 (13%)
Query: 457 VIKIIHDQWFIDYGNSEWKEKARKALARMKIYPE-TRRAQFEAIIDWLDKKACARKVGLG 515
+I+I+ DQWFI ++ K++ + + +PE R +F ++ +R+ G
Sbjct: 408 IIQIVTDQWFITI--TDVKDELLANMDTSEWHPEWARDNRFRDFVENAPDWNVSRQRYWG 465
Query: 516 TPLP-WDPEWVIESLSDSTIYMAYYTISRHINRLREEGRLDPEKLTPEFFDYIFLEEFSE 574
P+P W PE D + ++ ++ + +D K T + D E+ +E
Sbjct: 466 IPVPIWTPEDWSGDAEDVLVVGTREELAALADQDVDPASVDLHKPTVD--DITITEDGTE 523
Query: 575 EREKELEKKTGIPAEIIH-------EMKEEFEYWYPLDWRCSGKDLIPNHLTFFIFNHVA 627
+ + + E +++F+ +P D D + A
Sbjct: 524 YTRVPDVFDVWLDSSVASWGTLNYPEQEDDFDELWPADLIMEAHDQTRGWFWSQLGMGTA 583
Query: 628 IFREEHWPKGIAVNGFGTL-EGQKMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSD 686
+ + + + ++G+ + +G+ MSKSKG + + I+E GAD +R++++S+ D
Sbjct: 584 ALGDVPYEE-VLMHGYANMPDGRGMSKSKGITIEPNEVIDEYGADPMRMFLLSVTPQGDD 642
Query: 687 FDWRRKEVGKLRRQLE------RFYELISQFAEYEAK--------------ENVELKTID 726
+ E ++R L RF +++A + +L+T+D
Sbjct: 643 MSFSWDETENMQRDLNILWNVFRFPRPYMALDDFDANVPAAFGGDDAGVGIADADLETVD 702
Query: 727 KWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDL-RWYMRRTEGR--DDEAK---- 779
+WLL RL T E+F A+ ++ DL R+Y++ R +D+A
Sbjct: 703 EWLLSRLQHVKADATAHWEDFEQHRALDAVLEFVVEDLSRYYVQVVRERMWEDDASASKT 762
Query: 780 ---RFVLRKLADIWVRLMAPFTPHICEELWEKLGGE-GF--VSLAKWPEPVDEWWNEEVE 833
+ R L ++ V L+AP+ P + EEL+ L G+ G+ V +A WP
Sbjct: 763 AAYATMQRVLLEV-VALLAPYAPFVTEELYSHLTGDRGYDTVHMADWP-----------T 810
Query: 834 VEEDFIKSLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEKRE 882
VEE +E ++ A+ E+ A + +W V VV + E
Sbjct: 811 VEESLRAPALEADVAVLRAAE-EAGSHARQQAGRKLRWPVTRVVVDAAE 858
Score = 73.0 bits (176), Expect = 2e-11
Identities = 84/357 (23%), Positives = 143/357 (39%), Gaps = 47/357 (13%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKR 68
+EE+ W +E + + + F+ PY SG H+G T+ D R+ R
Sbjct: 16 VEERVFSYWEAVDAYEQTVDHRADAETFFFVDGPPYTSGAAHMGTTWNKTLKDAYIRYHR 75
Query: 69 MQGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKY 128
MQGY+V G+ + G PI K + +D+ + EE E+
Sbjct: 76 MQGYDVTDRPGYDMHGLPI-----ETKVEEQLGFESKKDIQEFGEEAF--IEECKRFADD 128
Query: 129 FMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPV 188
+ + F G +DW + T P + + W F ++ + G + +G + P
Sbjct: 129 NLDGLQSDFQSFGVWMDWDNPYKTVD--PSYMEAAWWAFSEVHDNGLVERGQRSISQCPR 186
Query: 189 VGTPLGDHDLMEGEDV--PILEYVIIKFELKEGDETIYLPAATLRPETVYGVTNMWINPN 246
T + +++ +E EDV P + YV + +EG ++ T P T+ + ++ +
Sbjct: 187 CETAIANNE-VEYEDVTDPSI-YVRFDLDDREGSLVVW----TTTPWTIPANQFVAVDED 240
Query: 247 ATY--VKAKVKRGGKEETWIISKEAAYKLS---FQDREIEVIEEFKGEKLIGKYVRNPVT 301
Y V+A G + ++ S+ LS + D EI + + G LIG + P
Sbjct: 241 GDYQQVRATTPDGETDVLYVASECVEDVLSAGGYSDHEI--VADHSGSDLIG-WSYTPPL 297
Query: 302 GDEVIILPAEFVDPD-------------NATGVVMSVPAHAPFDHVALEDLKRESEI 345
D V PA D D + TG+V S P H ED +R +E+
Sbjct: 298 ADAV---PANPTDADGTHEVYHGDWVEADRTGLVHSAPGHGE------EDFERGAEL 345
>pir||T30889 valine--tRNA ligase (EC 6.1.1.9) - Giardia lamblia
>gi|3219290|dbj|BAA28839.1| (AB008525) Valyl tRNA
Synthetase [Giardia intestinalis]
Length = 1218
Score = 76.5 bits (185), Expect = 1e-12
Identities = 58/199 (29%), Positives = 86/199 (43%), Gaps = 21/199 (10%)
Query: 5 NFRAIEEKWQKRWLEAKVFEP----NIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIP 60
N IE+ W + W A F P NI+ K KF + + P ++G LH+GHA T +I
Sbjct: 62 NPSVIEKSWYEWWEAAGFFSPDMQKNIRSKDSRCKFTLLIPPPNVTGSLHIGHALTNSIQ 121
Query: 61 DVIARFKRMQGYNVLFPMGWHITGSPIVGIAER----IKNRDPHTIWIYRDVYKVPEEIL 116
D + R+ RM GY L+ G G + ER + + H + R + E
Sbjct: 122 DALVRWYRMMGYRTLYLPGLDHAGIATQSVVERNIMKTEGKTRHDLGRERFL-----ERA 176
Query: 117 WTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYI 176
W +++ F G S DWSR +T L P S+ F+KL +G I
Sbjct: 177 WAWKEQ------FGGRILSQLRILGSSFDWSRSVFT--LDPARSRVHNESFVKLFNRGLI 228
Query: 177 VKGAHRVRWDPVVGTPLGD 195
+ + V WD + T + D
Sbjct: 229 YRDSRLVNWDCSLQTAVSD 247
>sp|P36422|SYI_TETTH ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|283498|pir||A42399 isoleucine--tRNA ligase (EC
6.1.1.5) - Tetrahymena thermophila
>gi|161801|gb|AAA30122.1| (M30942) transfer RNA-Ile
synthetase [Tetrahymena thermophila]
Length = 1081
Score = 75.3 bits (182), Expect = 3e-12
Identities = 93/402 (23%), Positives = 166/402 (41%), Gaps = 43/402 (10%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
+F EE K W E F+ ++ F P+ +G H G+ TI DV+
Sbjct: 15 DFPKEEENILKFWDEINAFKQQLEKTKDCPPFTFYDGPPFATGLPHYGNLLAGTIKDVVC 74
Query: 65 RFKRMQGYNVLFPMGWHITGSPIVGIAER---IKNRDPHTIWIYRDVYKVPEEILWTFED 121
R+ G V GW G P+ ++ I NR +E+L D
Sbjct: 75 RYASQNGKYVERRFGWDCHGLPVEYEIDKKLGITNR---------------QEVLKMGVD 119
Query: 122 PVN-----IVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYI 176
N IV + + + R G VD+ ++ T L F + + W F ++ +KG +
Sbjct: 120 KYNAECRSIVMRYAQEWRSIVNRFGRWVDFDNDYKTLDL--KFMESVWWVFKQMFDKGLV 177
Query: 177 VKGAHRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEGDETIYLPAATLRPETVY 236
+G + + T L + + + + I F+ E +T ++ A T P T+
Sbjct: 178 YRGCKVMPYSNGCATVLSNFETQQNYKEVDDPSLFIAFKTAEDPKTKFI-AWTTTPWTLP 236
Query: 237 GVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDRE-IEVIEEFKGEKLIGK- 294
+ IN + YV KV +E +I+++ +L +D++ +++E+FKG +L+G+
Sbjct: 237 SNLALVINKDFDYV--KVLDAKTQEHYILAECRLPELYKKDKDGYKILEKFKGSELVGRE 294
Query: 295 ------YVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVK 348
Y + IL +FV D TG+V P D+ + ++K
Sbjct: 295 YEPLFPYFLSRKQDGCFRILAGDFVTADAGTGIVHCAPGFGDDDYKV-----SVANNIIK 349
Query: 349 YDIDPRIVEEITYISLIKLEGYGEFPAVEEVQKLGIKSQKDR 390
D P V+E + + + + G + ++E KL K+ K+R
Sbjct: 350 PDDPPVPVDENGHFTNVVSDFAGVY--IKEADKLIRKNLKER 389
>pir||T27465 hypothetical protein Y87G2A.m - Caenorhabditis elegans
Length = 634
Score = 74.9 bits (181), Expect = 4e-12
Identities = 81/335 (24%), Positives = 135/335 (40%), Gaps = 49/335 (14%)
Query: 9 IEEKWQKRWLEAKVFEPNIKDKPKE-----KKFYITVAFPYLSGHLHVGHARTYTIPDVI 63
+E W W + F+P DK F + + P ++G+LHVGHA T+ D I
Sbjct: 88 VESGWYSWWEKEGFFKPEYIDKLNPGSNPADSFTVCIPPPNVTGNLHVGHALATTVEDTI 147
Query: 64 ARFKRMQGYNVLFPMGWHITG-SPIVGIAERIKNRDPHTIW-IYRDVYKVPEEILWTFED 121
RF RM G LF G G + V + +R+K T + RD + + +W +++
Sbjct: 148 TRFNRMHGKRTLFNPGCDHAGIATQVVVEKRLKRERGLTRHDLGRDRF---NQEVWHWKN 204
Query: 122 PVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAH 181
V Y + F + G SVDW R +T + P + + F+++ E G I +
Sbjct: 205 EKGDVIY------DQFRKLGASVDWDRAVFT--MDPKMCRAVTEAFIRMHESGTIYRSNR 256
Query: 182 RVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKE--GDETIYLPAATLRPETVYGVT 239
V W + + + D I+ + KE G I +P + E +GV
Sbjct: 257 LVNWSCALRSAISD----------------IEVDKKELTGSTLIAVPGYDKKIE--FGVL 298
Query: 240 NMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNP 299
N + K G +E ++S + ++ + + L+GK +P
Sbjct: 299 NSF----------AYKIQGSDEEIVVSTTRIETMLGDSGVAVHPDDQRYKHLVGKQCIHP 348
Query: 300 -VTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDH 333
+ + I FV+ + TG V PAH D+
Sbjct: 349 FIPTRNLPIFADSFVEMEFGTGAVKITPAHDHNDY 383
>sp|O33768|SYL_SULSO LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)
>gi|2253617|gb|AAB63016.1| (U82227) leucyl-tRNA
synthetase [Sulfolobus solfataricus]
Length = 183
Score = 74.9 bits (181), Expect = 4e-12
Identities = 54/189 (28%), Positives = 99/189 (51%), Gaps = 19/189 (10%)
Query: 792 RLMAPFTPHICEELW-EKLGGEGFVSLAKWPEPVDEWWNEEVEVEEDFIKSLIEDIKEII 850
+L+ PF PH+ EE+W E L + ++ WPE +E +E +++K ++EDI+ I+
Sbjct: 1 KLITPFAPHLAEEIWHEILKQKTYIVNEGWPEVEGSKMDELTLLEHEYMKRIVEDIRSIL 60
Query: 851 EVAKIESPKRAYIYTAPEWKWKVYEVVAEKREFKSAMAELMKDEEIRK-HGKEVAKLVQA 909
+ K +PK IY + ++ + R+ A ++ K +I K +E A+++Q
Sbjct: 61 NIFK-GTPKLIKIYALNDSRY-----MELLRDAIVANGQMKKFMDIHKPKSREDARILQK 114
Query: 910 IIKER-AFDVK--------RIDEEKVLRESKDFLEKELGLEVIINP--EEDKGGKKRQAI 958
I E D K I+E VL + ++ ++L ++++I P EE K ++A+
Sbjct: 115 IFNESLEIDDKMKKLVTNYNINEVDVLNKLSKYIRRKLNVDILIEPYDEEVKKTYNKEAM 174
Query: 959 PLKPAVFIE 967
PL+PA+ IE
Sbjct: 175 PLRPAIIIE 183
>pir||G82894 isoleucyl-tRNA synthetase UU410 [imported] - Ureaplasma urealyticum
>gi|6899398|gb|AAF30821.1|AE002138_8 (AE002138)
isoleucyl-tRNA synthetase [Ureaplasma urealyticum]
Length = 900
Score = 74.5 bits (180), Expect = 5e-12
Identities = 78/354 (22%), Positives = 144/354 (40%), Gaps = 36/354 (10%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIA 64
N E K Q+ W+E +++E + +K F + PY +G++H+GHA + D +
Sbjct: 20 NLNVKEPKIQQFWVEHQIYEKLLTKNKDKKPFILHDGPPYANGNIHIGHALNKILKDFVV 79
Query: 65 RFKRMQGYNVLFPMGWHITGSPI-VGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPV 123
+ M Y + GW G PI V ++++IK + L E
Sbjct: 80 SYHNMNNYYSPYIPGWDTHGLPIEVALSKKIKLSN-----------------LSVNERRE 122
Query: 124 NIVKYFMKAAK---ETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGA 180
KY ++ + F+R G D+ + + T + F + +KG+I +
Sbjct: 123 QCKKYALEQVNNQIQQFLRLGMISDFKQRYLTLDHNYEIDQL--KLFTYMLKKGFIYQDF 180
Query: 181 HRVRWDPVVGTPLGDHDLMEGEDVPILEYVIIKFELKEG---DETIYLPAATLRPETVYG 237
V W T L + ++ + YV +K D+ L T P T+
Sbjct: 181 KPVFWSWSSQTALAESEIEYADRQSSAIYVKMKVVDHNDLFTDKPTSLVIWTTTPWTLPA 240
Query: 238 VTNMWINPNATYVKAKVKRGGKEETWIISKEA----AYKLSFQDREIEVIEEFKGEKLIG 293
+ I+P Y + K E +II+K K+ F+D + I++FK L
Sbjct: 241 NLAIAIHPELVYSLIEY----KNENYIIAKPLVETFVKKVGFED--YKWIKDFKANTLEK 294
Query: 294 KYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILV 347
+P++ ++ E+V ++ TG+V + PA D+ A + E+ +++
Sbjct: 295 IKYISPISKKHAFVIMDEYVSANDGTGLVHNAPAFGLEDYYACKKYGIETVVMI 348
>sp|P41257|SYI_CAMJE ISOLEUCYL-TRNA SYNTHETASE (ISOLEUCINE--TRNA LIGASE) (ILERS)
>gi|558850|gb|AAA91296.1| (U15295) isoleucyl-tRNA
synthetase [Campylobacter jejuni]
Length = 917
Score = 74.5 bits (180), Expect = 5e-12
Identities = 83/362 (22%), Positives = 145/362 (39%), Gaps = 47/362 (12%)
Query: 5 NFRAIEEKWQKRWLEAKVFEPNIKDKPK--EKKFYITVAFPYLSGHLHVGHARTYTIPDV 62
N +E + K+W E +K+ K +K F + PY +GH+H+GHA + +
Sbjct: 19 NLAELEPQRFKKWFEQNYAYEKMKENRKNAKKSFTLHDGPPYANGHIHIGHALNKILKET 78
Query: 63 IARFKRMQGYNVLFPMGWHITGSPI-----VGIAERIKNRDPHTIWIYRDVYKVPEEILW 117
I + +G +V F GW G PI V + E+ K+ I R+ +
Sbjct: 79 IIKTHYFKGESVRFTPGWDCHGLPIEQQVEVKLGEKKKSLSKKEI---REFCR------- 128
Query: 118 TFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIV 177
F+ +E F G DW + + T F I ++ +KG +
Sbjct: 129 ------QHASEFVDIQREEFKNLGIIADWDKPYLTMKF--EFEAAIYRTLCEIAKKGLLC 180
Query: 178 KGAHRVRWDPVVGTPLGDHDL--MEGEDVPILEYVIIKFELKEGDETIYLPAA----TLR 231
+ + V W + L + ++ + ED I +V ++K + A+ T
Sbjct: 181 ERSKPVFWSWAAKSALAEAEVEYQDKEDYSI--FVAFDLDVKACKKLGVSKASAVIWTTT 238
Query: 232 PETVYGVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREI---EVIEEFKG 288
P T+ + +NPN YV K +I A K S ++ + E+ +E
Sbjct: 239 PWTLVANQAIALNPNENYVITK--------EGLIFASALLK-SMVEKGLTSGEIQKELNA 289
Query: 289 EKLIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFDHVALEDLKRESEILVK 348
++ NP+ G + +++ E V D +G+V + P H D+ A LK E+L+
Sbjct: 290 KEFEKLEAINPLNGRKSVLIMGEHVLMDGGSGLVHTAPGHGEDDYYAC--LKYGIEVLMP 347
Query: 349 YD 350
D
Sbjct: 348 VD 349
>pir||D82293 isoleucyl-tRNA synthetase VC0682 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9655121|gb|AAF93847.1|
(AE004154) isoleucyl-tRNA synthetase [Vibrio cholerae]
Length = 949
Score = 71.0 bits (171), Expect = 6e-11
Identities = 83/342 (24%), Positives = 137/342 (39%), Gaps = 37/342 (10%)
Query: 10 EEKWQKRWLEAKVFEPNIKDKPKEKKFYITVAFPYLSGHLHVGHARTYTIPDVIARFKRM 69
E + +RW + ++ + K +K F + PY +G +H+GHA + DVI + K +
Sbjct: 25 EPEMLQRWYQEDLYGAIRQAKKGKKSFVLHDGPPYANGDIHIGHALNKILKDVIIKSKTL 84
Query: 70 QGYNVLFPMGWHITGSPIVGIAERIKNRDPHTIWIYRDVYKVPEEILWTFEDPVNIVKYF 129
G++ + GW G PI + E+ + + K E E
Sbjct: 85 SGFDAPYIPGWDCHGLPIELMVEKKVGKPGQKVTAAEFREKCREYAAGQVE--------- 135
Query: 130 MKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKLKEKGYIVKGAHRVRWDPVV 189
KE+F R G +W + Y T F + I K+ + G+++KG V W
Sbjct: 136 --GQKESFKRLGILGEWDKP-YRTMDFVTEANIIR-ALGKIADNGHLLKGFKPVHWCTDC 191
Query: 190 GTPLGDHDLMEGEDV-PILEY---------VIIKFELKEGDE---TIYLPAATLRPETVY 236
G+ L + ++ V P ++ V+ KF L G E + + T P T+
Sbjct: 192 GSALAEAEVEYKNKVSPSIDVRFKAADEAAVLAKFGLAAGHEGKGDVSIVIWTTTPWTLP 251
Query: 237 GVTNMWINPNATYVKAKVKRGGKEETWIISKEAAYKLSFQDREIEVIEEF------KGEK 290
+ + + YV +V+ G + E I++ E A S DR IE F G
Sbjct: 252 ANRAVCLRADLEYVLIQVE-GEQPERIIVASELA--KSVMDR--AGIEHFHNLGFATGAD 306
Query: 291 LIGKYVRNPVTGDEVIILPAEFVDPDNATGVVMSVPAHAPFD 332
L ++P V + + V D+ TGVV + P H D
Sbjct: 307 LELVQFQHPFYSFTVPAILGDHVTTDSGTGVVHTAPGHGQED 348
>emb|CAB66249.1| (AL136518) leucyl-tRNA synthetase. [Streptomyces coelicolor A3(2)]
Length = 966
Score = 70.6 bits (170), Expect = 8e-11
Identities = 53/173 (30%), Positives = 82/173 (46%), Gaps = 13/173 (7%)
Query: 650 KMSKSKGNVLNFIDAIEENGADVVRLYIMSLAEHDSDFDWRRKEVGKLRRQLERFYE-LI 708
KM KS N + + E GAD +RLY M++ D W + V R L+R + ++
Sbjct: 734 KMGKSLKNAVTPDEICAEYGADTLRLYEMAMGPLDVSRPWDTRAVVGQFRLLQRLWRNVV 793
Query: 709 SQFAEYEAKENVELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRWYM 768
+ + +V ID L L+KA++G + LE R TA+ + + +L ++
Sbjct: 794 DEDTGELSVADVAESDIDAGTLRALHKAVDGVRQDLEGMRFNTAI-----AKVTELNNHL 848
Query: 769 RRTEGRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWP 821
+ G V R +A+ V L+AP PH+ EELW KLG E V +P
Sbjct: 849 TKAGGP-------VPRSVAERLVLLVAPLAPHVAEELWRKLGHESSVVHEDFP 894
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.139 0.419
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 385727603
Number of Sequences: 2977
Number of extensions: 17677556
Number of successful extensions: 49554
Number of sequences better than 1.0e-10: 166
Number of HSP's better than 0.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 48461
Number of HSP's gapped (non-prelim): 502
length of query: 967
length of database: 189,106,746
effective HSP length: 56
effective length of query: 911
effective length of database: 155,591,474
effective search space: 141743832814
effective search space used: 141743832814
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 170 (70.6 bits)