BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB1791 (mdh) DE:MALATE DEHYDROGENASE
         (362 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||H75131 malate dehydrogenase PAB1791 - Pyrococcus abyssi (st...   731  0.0
sp|O59028|MDH_PYRHO MALATE DEHYDROGENASE >gi|7449808|pir||B71073...   657  0.0
sp|Q58820|MDH1_METJA MALATE DEHYDROGENASE I >gi|2129100|pir||H64...   260  2e-68
pir||S08689 malate dehydrogenase (EC 1.1.1.37) - Methanothermus ...   260  2e-68
sp|P16142|MDH_METFE MALATE DEHYDROGENASE >gi|99123|pir||S08981 m...   260  2e-68
pir||H69027 malate dehydrogenase - Methanobacterium thermoautotr...   240  3e-62
gb|AAF51687.1| (AE003593) CG10512 gene product [Drosophila melan...   236  2e-61
pir||T20396 hypothetical protein F36A2.3 - Caenorhabditis elegan...   236  2e-61
pir||E69852 malate dehydrogenase homolog yjmC - Bacillus subtili...   232  4e-60
pir||T18570 probable malate dehydrogenase (EC 1.1.1.37) - Caenor...   232  4e-60
gi|10956557 hypothetical protein [Lactobacillus helveticus] >gi|...   219  6e-56
sp|P77555|ALLD_ECOLI UREIDOGLYCOLATE DEHYDROGENASE >gi|7449805|p...   185  7e-46
sp|P30178|YBIC_ECOLI HYPOTHETICAL 38.9 KDA PROTEIN IN DING-GLNQ ...   177  2e-43
emb|CAB45039.1| (AL078635) putative carboxylic acid dehydrogenas...   177  2e-43
gb|AAA53657.1| (L02123) YbiC [Escherichia coli]                       174  2e-42
gb|AAG22250.1| (AE003482) CG18808 gene product [Drosophila melan...   171  1e-41
sp|Q07251|LDH_ALCEU L-LACTATE DEHYDROGENASE >gi|2120947|pir||I39...   152  6e-36
gb|AAF55744.1| (AE003729) CG17199 gene product [Drosophila melan...   152  8e-36
sp|P44995|YIAK_HAEIN HYPOTHETICAL PROTEIN HI1031 >gi|1074616|pir...   140  3e-32
pir||S47796 hypothetical protein o332 - Escherichia coli >gi|466...   137  2e-31
sp|P37672|YIAK_ECOLI HYPOTHETICAL 36.6 KDA PROTEIN IN AVTA-SELB ...   136  3e-31
pir||B83488 probable L-malate dehydrogenase PA1252 [imported] - ...   133  3e-30
pir||T20825 hypothetical protein F13D12.1 - Caenorhabditis elegans     89  1e-16

>pir||H75131 malate dehydrogenase PAB1791 - Pyrococcus abyssi (strain Orsay)
           >gi|5458280|emb|CAB49769.1| (AJ248285) MALATE
           DEHYDROGENASE [Pyrococcus abyssi]
           Length = 362
           
 Score =  731 bits (1867), Expect = 0.0
 Identities = 362/362 (100%), Positives = 362/362 (100%)

Query: 1   MFEKGYVDENYVRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRL 60
           MFEKGYVDENYVRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRL
Sbjct: 1   MFEKGYVDENYVRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRL 60

Query: 61  KRYVDGILSGGINLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIV 120
           KRYVDGILSGGINLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIV
Sbjct: 61  KRYVDGILSGGINLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIV 120

Query: 121 AVRNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKP 180
           AVRNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKP
Sbjct: 121 AVRNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKP 180

Query: 181 FLLDMATSVVPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELL 240
           FLLDMATSVVPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELL
Sbjct: 181 FLLDMATSVVPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELL 240

Query: 241 GGHKGYGLSLMVDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRM 300
           GGHKGYGLSLMVDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRM
Sbjct: 241 GGHKGYGLSLMVDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRM 300

Query: 301 SEMINEIKNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGVKGL 360
           SEMINEIKNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGVKGL
Sbjct: 301 SEMINEIKNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGVKGL 360

Query: 361 EV 362
           EV
Sbjct: 361 EV 362


>sp|O59028|MDH_PYRHO MALATE DEHYDROGENASE >gi|7449808|pir||B71073 probable malate
           dehydrogenase - Pyrococcus horikoshii
           >gi|3257697|dbj|BAA30380.1| (AP000005) 360aa long
           hypothetical malate dehydrogenase [Pyrococcus
           horikoshii]
           Length = 360
           
 Score =  657 bits (1676), Expect = 0.0
 Identities = 312/360 (86%), Positives = 344/360 (94%)

Query: 1   MFEKGYVDENYVRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRL 60
           MFEKGYVDENY+R+PKD LFSF+VRVLTKLG PEEDAKIVADNL+MADLRG+ESHGVQRL
Sbjct: 1   MFEKGYVDENYIRVPKDRLFSFIVRVLTKLGVPEEDAKIVADNLVMADLRGVESHGVQRL 60

Query: 61  KRYVDGILSGGINLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIV 120
           KRYVDGI+SGG+NLHP+I++IREGPSYAL+DGDEG GQVVGY++MKLAI+KA+ TGIGIV
Sbjct: 61  KRYVDGIISGGVNLHPKIRVIREGPSYALIDGDEGLGQVVGYRSMKLAIKKAKDTGIGIV 120

Query: 121 AVRNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKP 180
             RNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGG+ERILGTNPIALAAPTK KP
Sbjct: 121 IARNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGIERILGTNPIALAAPTKDKP 180

Query: 181 FLLDMATSVVPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELL 240
           FLLDMATSVVPIGKLEVYRRKG++IPEGWAIN +G IT  VEEVFNGG+LLPLGGFGELL
Sbjct: 181 FLLDMATSVVPIGKLEVYRRKGKDIPEGWAINREGNITTKVEEVFNGGALLPLGGFGELL 240

Query: 241 GGHKGYGLSLMVDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRM 300
           GGHKGYGLSLMVDILSGILSGGTWSK+VKNT+EK SNVCHFFM I+IEHF PLEEFK ++
Sbjct: 241 GGHKGYGLSLMVDILSGILSGGTWSKYVKNTSEKGSNVCHFFMVIDIEHFIPLEEFKEKI 300

Query: 301 SEMINEIKNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGVKGL 360
           S+MI EIK+SRKHP+FERIWIHGEKGFLTMETRLKLGIPIY+KVL+ELNEIA+RVGV+GL
Sbjct: 301 SQMIEEIKSSRKHPEFERIWIHGEKGFLTMETRLKLGIPIYRKVLEELNEIAKRVGVEGL 360


>sp|Q58820|MDH1_METJA MALATE DEHYDROGENASE I >gi|2129100|pir||H64477 malate dehydrogenase
           (EC 1.1.1.37) - Methanococcus jannaschii
           >gi|1592075|gb|AAB99436.1| (U67583) malate dehydrogenase
           [Methanococcus jannaschii]
           Length = 344
           
 Score =  260 bits (657), Expect = 2e-68
 Identities = 153/341 (44%), Positives = 209/341 (60%), Gaps = 21/341 (6%)

Query: 23  VVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLHPRIKIIR 82
           ++ VL K G PEEDAKI AD  + ADL+G  SHG+ R  +Y+  +  G IN  P IKI++
Sbjct: 12  IIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGNINPKPDIKIVK 71

Query: 83  EGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGYYALMAAEEG 142
           E P+ A++DGD G GQVVG KAM+LAI+KA+  G+G+VA RN+NH+GIAGYY+ +A  + 
Sbjct: 72  ESPATAVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIAGYYSELAMNQD 131

Query: 143 MIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVPIGKLEVYRRKG 202
           MIGI++TN+ P +AP GG E+ILGTNPIA+A       F LDMAT+ +  GK+    RK 
Sbjct: 132 MIGITITNTEPAMAPFGGKEKILGTNPIAIAFKGNKYKFSLDMATASIARGKILEALRKK 191

Query: 203 EEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVDILSGILSGG 262
            +IPEG A++  G+ T    +    G +LP        GG KGYGL+L +++LS I  G 
Sbjct: 192 IKIPEGCAVDKDGKPTTDPAKALE-GCILP-------FGGPKGYGLALAIEMLSAI-GGA 242

Query: 263 TWSKHVKNT--NEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSRKHPDFERIW 320
                VK T   E+       F+AIN E F   EEFK ++ E+++EIKNS     FE I 
Sbjct: 243 EVGTKVKGTANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEGFE-IL 301

Query: 321 IHGEKGFLTMETRLKL----GIPIYKKVLDELNEIARRVGV 357
           I GE     +E R K+    G  I K + ++L EI   +G+
Sbjct: 302 IPGE-----IEERNKMKRKDGFEIDKNLYNQLKEICNELGL 337


>pir||S08689 malate dehydrogenase (EC 1.1.1.37) - Methanothermus fervidus
           (fragment) >gi|44278|emb|CAA36133.1| (X51840) L-malate
           dehydrogenase (AA 339) [Methanothermus fervidus]
           Length = 339
           
 Score =  260 bits (657), Expect = 2e-68
 Identities = 149/348 (42%), Positives = 212/348 (60%), Gaps = 17/348 (4%)

Query: 14  IPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGIN 73
           I  +E  S ++++L  LG  EE AKI AD ++ ADL+G  SHG+ R  +YV+GI  G I 
Sbjct: 3   ISPEEERSLIIKILNALGVSEEHAKITADVIVDADLKGFTSHGIGRFPQYVEGIKLGTIK 62

Query: 74  LHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGY 133
               I+I +E  S AL++G+   GQVV YK MKLAIEKA+ TG+GIV + +SNH+GIAGY
Sbjct: 63  TSGNIEIEKETDSVALINGNHLLGQVVAYKGMKLAIEKAKNTGVGIVGIHDSNHFGIAGY 122

Query: 134 YALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVPIG 193
           Y+ MA +  MIGI+MTN+ P VAP GG   +LGTNPIA++ P+      +DM+T+ V  G
Sbjct: 123 YSDMAMKNDMIGITMTNTEPAVAPLGGKIPVLGTNPIAISIPSNEYYVAVDMSTAAVARG 182

Query: 194 KLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVD 253
           KL    RK E+IPEG A++  G  T    E  N GS+LP        GGHKGY L  M++
Sbjct: 183 KLLEAARKNEKIPEGIAVDKNGNPTTDPNEALN-GSILP-------FGGHKGYALCFMIE 234

Query: 254 ILSGILSGGTWSKHVKNTNEKNSNVC---HFFMAINIEHFTPLEEFKGRMSEMINEIKNS 310
           IL+G L    +   VK T +  S +C      +AI+   F  +EEFK  + E + EIK++
Sbjct: 235 ILAGPLVKAEFGSKVKGTVDP-SQMCTKGDLLIAIDPSKFYDIEEFKRNVDEFVKEIKST 293

Query: 311 RKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGVK 358
            K      + I G++  + ++ R K GI + KK++++L EIA  + ++
Sbjct: 294 GKD-----VLIPGDRERMNIKKREKEGIELDKKLVEKLKEIADELNIE 336


>sp|P16142|MDH_METFE MALATE DEHYDROGENASE >gi|99123|pir||S08981 malate dehydrogenase (EC
           1.1.1.37) - Methanothermus fervidus
           >gi|809713|emb|CAA36010.1| (X51714) L-malate
           dehydrogenase (AA 1-339) [Methanothermus fervidus]
           Length = 339
           
 Score =  260 bits (657), Expect = 2e-68
 Identities = 149/348 (42%), Positives = 212/348 (60%), Gaps = 17/348 (4%)

Query: 14  IPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGIN 73
           I  +E  S ++++L  LG  EE AKI AD ++ ADL+G  SHG+ R  +YV+GI  G I 
Sbjct: 3   ISPEEERSLIIKILNALGVSEEHAKITADVIVDADLKGFTSHGIGRFPQYVEGIKLGTIK 62

Query: 74  LHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGY 133
               I+I +E  S AL++G+   GQVV YK MKLAIEKA+ TG+GIV + +SNH+GIAGY
Sbjct: 63  TSGNIEIEKETDSVALINGNHLLGQVVAYKGMKLAIEKAKNTGVGIVGIHDSNHFGIAGY 122

Query: 134 YALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVPIG 193
           Y+ MA +  MIGI+MTN+ P VAP GG   +LGTNPIA++ P+      +DM+T+ V  G
Sbjct: 123 YSDMAMKNDMIGITMTNTEPAVAPLGGKIPVLGTNPIAISIPSNEYYVAVDMSTAAVARG 182

Query: 194 KLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVD 253
           KL    RK E+IPEG A++  G  T    E  N GS+LP        GGHKGY L  M++
Sbjct: 183 KLLEAARKNEKIPEGIAVDKNGNPTTDPNEALN-GSILP-------FGGHKGYALCFMIE 234

Query: 254 ILSGILSGGTWSKHVKNTNEKNSNVC---HFFMAINIEHFTPLEEFKGRMSEMINEIKNS 310
           IL+G L    +   VK T +  S +C      +AI+   F  +EEFK  + E + EIK++
Sbjct: 235 ILAGPLVKAEFGSKVKGTVDP-SQMCTKGDLLIAIDPSKFYDIEEFKRNVDEFVKEIKST 293

Query: 311 RKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGVK 358
            K      + I G++  + ++ R K GI + KK++++L EIA  + ++
Sbjct: 294 GKD-----VLIPGDRERMNIKKREKEGIELDKKLVEKLKEIADELNIE 336


>pir||H69027 malate dehydrogenase - Methanobacterium thermoautotrophicum
           (strain Delta H) >gi|2622314|gb|AAB85694.1| (AE000888)
           malate dehydrogenase [Methanobacterium
           thermoautotrophicum]
           Length = 341
           
 Score =  240 bits (605), Expect = 3e-62
 Identities = 141/348 (40%), Positives = 201/348 (57%), Gaps = 16/348 (4%)

Query: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71
           +RI  +E    +  +LT +  PEE + IVAD  + ADL+G  SHG+ R  +YVDG+  G 
Sbjct: 1   MRISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGT 60

Query: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131
           I     I I RE  S AL++G+  FG VV Y+AM+LAIEKAR TG+G+V V +SNH+G+A
Sbjct: 61  IRADGDITIERETESTALINGNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVA 120

Query: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVP 191
           GYY+ MA    MIG+ + N+ P VAP GG + ILGTNP+A+  P+      +DMATS   
Sbjct: 121 GYYSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVAIGIPSNRYYVSVDMATSASA 180

Query: 192 IGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLM 251
            GKL    RKGE IPE  A++++G+ T   E     GS+LP        GGHKGY LS M
Sbjct: 181 RGKLLEAARKGESIPENVALDAEGKPTTDPEMALK-GSILP-------FGGHKGYALSFM 232

Query: 252 VDILSGILSGGTWSKHVKNT--NEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKN 309
           ++IL+G L G  +   V  T   E+        MAI+       +EF+ ++ E I E+K+
Sbjct: 233 IEILAGPLVGAAFGTAVTGTANPEEMCTKGDLMMAIDPSKMVDPDEFRAQVDEFIEEVKS 292

Query: 310 SRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGV 357
           S        + I G+   + ++ R   GI + +K+L+ +  IAR + +
Sbjct: 293 SGD------VLIPGDIESMNIKRRRAEGIELDEKLLERILGIARELDI 334


>gb|AAF51687.1| (AE003593) CG10512 gene product [Drosophila melanogaster]
           Length = 446
           
 Score =  236 bits (597), Expect = 2e-61
 Identities = 126/309 (40%), Positives = 191/309 (61%), Gaps = 8/309 (2%)

Query: 22  FVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLHPRIKII 81
           F++     +  P+  A+  AD L+ AD RG  SHG+ RL+ Y++ +     +     KI+
Sbjct: 102 FMIDCFKAVKVPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTDGAAVPKIL 161

Query: 82  REGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGYYALMAAEE 141
           +E P+ A +DG  G G VVG   M LAI+KA+  G+G V  + SNHYG+AG+YA+ A ++
Sbjct: 162 KETPATAWVDGLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGWYAIRAMDQ 221

Query: 142 GMIGISMTNSRPLVAPTGGVERILGTNPIALAA-PTKGKPFLLDMATSVVPIGKLEVYRR 200
           G++G+SMTN+ PL+APT   E  LGTNP++L A  T G  FLLDMAT+ V +GK+E+ RR
Sbjct: 222 GLVGMSMTNTSPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAVGKIEIQRR 281

Query: 201 KGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVDILSGILS 260
           KG  +P+GWA +  GE+T   E  F+ G L+PLGG  EL  G+KGYGL  MVDILSG++S
Sbjct: 282 KGAPLPDGWAQDPSGEVTNDAELGFSTGCLMPLGG-SELTSGYKGYGLGAMVDILSGVMS 340

Query: 261 GGTWSKHVKNTN----EKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSRKHPDF 316
           G  +S  V+       +  +++   F+A++   F P   F+ RM++  + ++ +      
Sbjct: 341 GANYSTQVRKWTHAGADSAADLGQVFIAVDPNCFAP--NFEERMADFNSRLRGATPTDPS 398

Query: 317 ERIWIHGEK 325
           + + + G+K
Sbjct: 399 KPVLLAGDK 407


>pir||T20396 hypothetical protein F36A2.3 - Caenorhabditis elegans
           >gi|3875353|emb|CAB09417.1| (Z96047) cDNA EST
           EMBL:M88984 comes from this gene~cDNA EST EMBL:T01848
           comes from this gene~cDNA EST yk592h12.3 comes from this
           gene~cDNA EST yk592h12.5 comes from this gene
           [Caenorhabditis elegans] >gi|3876781|emb|CAB03073.1|
           (Z81077) cDNA EST EMBL:M88984 comes from this gene~cDNA
           EST EMBL:T01848 comes from this gene~cDNA EST yk592h12.3
           comes from this gene~cDNA EST yk592h12.5 comes from this
           gene [Caenorhabditis elegans]
           Length = 372
           
 Score =  236 bits (597), Expect = 2e-61
 Identities = 140/360 (38%), Positives = 211/360 (57%), Gaps = 8/360 (2%)

Query: 3   EKGYVDENYVRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKR 62
           ++ + + + + I K++L SFV+  L K G   + A+ +A+ L+ +D RG  SHG+ RL  
Sbjct: 6   KREFNETDEIVISKEKLDSFVLECLAKAGCTGDHAQQLAETLLCSDYRGHYSHGINRLHI 65

Query: 63  YVDGILSGGINLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAV 122
           YV  ++     +    ++++   S A +DG+   G VVG   M+LA+EKA++ GIG V  
Sbjct: 66  YVHDLMMKSTAVTGTPQVLKSKGSTAWVDGNNLLGPVVGNFCMQLAVEKAKEFGIGWVVC 125

Query: 123 RNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAP-TKGKPF 181
           RNSNH+GIAG+YA  A   G++G++ TN+ P V PTG  E+ LG+NPI +AAP  +G  F
Sbjct: 126 RNSNHFGIAGWYADFACRNGLVGMAFTNTSPCVFPTGSREKSLGSNPICMAAPGMEGDSF 185

Query: 182 LLDMATSVVPIGKLEVYRRKGEE-IPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELL 240
            LDMA++ V  GK+EV  RKGE  IP  W  +  G+ T + +EV +GG L PLGG  E+ 
Sbjct: 186 FLDMASTTVAYGKIEVVDRKGETYIPGSWGADKNGDETHNPKEVLDGGGLQPLGG-SEIT 244

Query: 241 GGHKGYGLSLMVDILSGILSGGTWSKHVK--NTNEKNSNVCHFFMAINIEHFTPLEEFKG 298
           GG+KG GL +MV++L GI+ G  + K+++   T  K +++   F+AI+ E F P   F  
Sbjct: 245 GGYKGTGLCMMVEVLCGIMGGSAFGKNIRQWQTTSKTADLGQCFVAIDPECFAP--GFSN 302

Query: 299 RMSEMINEIKNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIY-KKVLDELNEIARRVGV 357
           R+ E  +E +N           + G+     M     LG  +Y KK LD L  +A R+GV
Sbjct: 303 RLQEFCDETRNLNPINPSRPPQVPGDPERAHMNMCDDLGGIVYKKKQLDHLKNLADRLGV 362


>pir||E69852 malate dehydrogenase homolog yjmC - Bacillus subtilis
           >gi|2612904|gb|AAC46328.1| (AF015825) malate
           dehydrogenase-like protein [Bacillus subtilis]
           >gi|2633586|emb|CAB13089.1| (Z99110) similar to malate
           dehydrogenase [Bacillus subtilis]
           Length = 337
           
 Score =  232 bits (586), Expect = 4e-60
 Identities = 136/341 (39%), Positives = 193/341 (55%), Gaps = 14/341 (4%)

Query: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71
           + I  +E    V + L   G  E DA+ VAD L+ ADLR + SHGV   + YV+ +L+GG
Sbjct: 4   ITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNVHSHGVLHTEHYVNRLLAGG 63

Query: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131
           IN   +      GP   +LDGD+GFG V    AM  AI+ A+K G+G+V   NS+H G  
Sbjct: 64  INPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAIDMAKKKGVGMVTAVNSSHCGAL 123

Query: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTK-GKPFLLDMATSVV 190
            Y+   AA+E +IG++MT++  +V P GG   ILGTNPIA   P K  KPF+LDMATS V
Sbjct: 124 SYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTNPIAYGVPAKHKKPFILDMATSKV 183

Query: 191 PIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSL 250
             GK+   R +G+EIPEGW ++  GE     ++V +  +           GG KGYGLS+
Sbjct: 184 AFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVVSLST----------FGGPKGYGLSI 233

Query: 251 MVDILSGILSGGTWSKHVK---NTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEI 307
           +VD+ SG+L+G  +  H+    N  ++   + H+  AIN   FT  + F  +M  MI+E+
Sbjct: 234 VVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFFTDWDTFLEQMDAMIDEL 293

Query: 308 KNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDEL 348
           + S     FER+++ GE   L  E   K GI I + V + L
Sbjct: 294 QQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL 334


>pir||T18570 probable malate dehydrogenase (EC 1.1.1.37) - Caenorhabditis
           elegans >gi|3947447|emb|CAA22133.1| (AL033535) predicted
           using Genefinder~cDNA EST EMBL:M88999 comes from this
           gene~cDNA EST yk268h6.3 comes from this gene~cDNA EST
           yk264b4.3 comes from this gene~cDNA EST yk331d3.3 comes
           from this gene~cDNA EST yk465f2.3 comes from this
           gene~cDNA EST yk3> >gi|3947542|emb|CAA88951.1| (Z49127)
           predicted using Genefinder~cDNA EST EMBL:M88999 comes
           from this gene~cDNA EST yk268h6.3 comes from this
           gene~cDNA EST yk264b4.3 comes from this gene~cDNA EST
           yk331d3.3 comes from this gene~cDNA EST yk465f2.3 comes
           from this gene~cDNA EST yk393>
           Length = 400
           
 Score =  232 bits (586), Expect = 4e-60
 Identities = 140/358 (39%), Positives = 205/358 (57%), Gaps = 17/358 (4%)

Query: 14  IPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGIN 73
           + KDE+  F+V  +TK+G  E  A  +A  L+  D+RG  SHG+ RL  YV  I      
Sbjct: 49  VAKDEMKRFMVECMTKVGATESHATQLALVLLEGDIRGHYSHGLNRLDMYVRDIEQNVCK 108

Query: 74  LHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGY 133
                 I++E    A +DG+   G VVG   M LAIEKA+  GIG V  + SNHYGIAG+
Sbjct: 109 GDGEPIILKEKAGTAWVDGNNLLGPVVGNFCMDLAIEKAKNAGIGWVVAKGSNHYGIAGW 168

Query: 134 YALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKG-KPFLLDMATSVVPI 192
           YAL A ++GM+G+SMTN+ P+  PT      LGTNPI+LAAP  G   F+LDMA++ V I
Sbjct: 169 YALRAMKKGMLGMSMTNTSPISFPTRSAVPALGTNPISLAAPGTGDDSFVLDMASTTVAI 228

Query: 193 GKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMV 252
           GK+E+  RK   +P  W +   G+ T    +V  GG LLPLGG  E+ GG+KGYGLS M+
Sbjct: 229 GKVELAARKENPVPLSWGVGEGGKETTDPTKVLYGGGLLPLGGV-EVSGGYKGYGLSSMI 287

Query: 253 DILSGILSGGTWSKHVKN--TNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNS 310
           +I  GIL+G  W  HV+   + +  +++   F+AI+ E F P   F  R+ + +  ++  
Sbjct: 288 EIFCGILAGAHWGPHVRKWMSTKSEADLGQCFVAIDPEAFAP--GFADRLQDFMQTMRAL 345

Query: 311 RKHPDFERIWIHGEKGFLTMETRLKL------GIPIYKKVLDELNEIARRVGVKGLEV 362
                  ++ + G+     ME R +       GIP +K  +  +N++A ++GVK +++
Sbjct: 346 PTSSPSFKVEVAGD-----MERRHEALVEQLGGIPYHKNQITFVNDLAAKLGVKTVDL 398


>gi|10956557 hypothetical protein [Lactobacillus helveticus]
           >gi|11280078|pir||T46704 hypothetical protein orf-361
           [imported] - Lactobacillus helveticus plasmid pLH1
           >gi|2687745|emb|CAA10971.1| (AJ222725) hypothetical
           protein [Lactobacillus helveticus]
           Length = 361
           
 Score =  219 bits (551), Expect = 6e-56
 Identities = 123/349 (35%), Positives = 194/349 (55%), Gaps = 17/349 (4%)

Query: 22  FVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLHPRIKII 81
           F+ +V       + D  ++AD L+ ADLRGI SHG+QRL  Y   I    I    ++K+I
Sbjct: 11  FLEKVFAARQFSKSDGALLADTLVDADLRGISSHGIQRLAWYTSMIKEHIIEPQNKLKVI 70

Query: 82  REGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGYYALMAAEE 141
           +E P+  L+D ++  GQ+    A K  I+K +K G+ +  +RNSNH+G AGYYA MAA++
Sbjct: 71  KETPTSLLIDANKNMGQIATAFAEKQLIKKTQKLGLSVAVIRNSNHFGTAGYYARMAAKQ 130

Query: 142 GMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVPIGKLEVYRRK 201
           G+IGI++TN+RPLV P    E  LG+N  A   P +  PF+ D ATS+V  GK+++  + 
Sbjct: 131 GLIGIALTNTRPLVVPPNATEAFLGSNAFAFPLPAEPHPFVFDGATSIVSSGKIQLLAKN 190

Query: 202 GEEIPEGWAINSKGEITRSVEEVFN------------GGSLLPLGGFGELLGGHKGYGLS 249
            + IP  WA+++   +    ++V N            GG +L LGG  +    +KG+G S
Sbjct: 191 NQPIPGDWAVDNHRRVMHDAQKVENNLAKVAFTEKQPGGGVLTLGGLLQSNSNYKGFGNS 250

Query: 250 LMVDILSGILSGGTWSKHVKNTNEK-NSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIK 308
           L+V++L+GIL+ G+ S    +TN+  + +   F + IN E F  L+  K    EM + ++
Sbjct: 251 LVVELLTGILAQGSIS---ADTNKPGHHDFSQFLLTINPELFGNLDNLKNSAEEMFDRLR 307

Query: 309 NSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGV 357
           + +  P  E I I G++ +      LK G+ I  K + EL  I   + +
Sbjct: 308 HLKHLPGAE-IMIPGDREYRRYAENLKQGVVIDDKTVAELKTIGEELAI 355


>sp|P77555|ALLD_ECOLI UREIDOGLYCOLATE DEHYDROGENASE >gi|7449805|pir||D64783 malate
           dehydrogenase homolog ylbC - Escherichia coli
           >gi|1773197|gb|AAB40269.1| (U82664) similar to M.
           fervidus malate dehydrogenase [Escherichia coli]
           >gi|1786727|gb|AAC73619.1| (AE000157) putative malate
           dehydrogenase (EC 1.1.1.37) [Escherichia coli K12]
           >gi|2735243|gb|AAB93858.1| (U89279) GlxB8 [Escherichia
           coli]
           Length = 349
           
 Score =  185 bits (465), Expect = 7e-46
 Identities = 113/341 (33%), Positives = 168/341 (49%), Gaps = 14/341 (4%)

Query: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71
           ++I ++ L   +   L + G   E A  VA+ L+ AD RGI SHG  R++ Y + I  GG
Sbjct: 1   MKISRETLHQLIENKLCQAGLKREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGG 60

Query: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131
            N  P  ++   GP  A+L  D   GQV     M+ AI+ A++ G+ +V +    H G  
Sbjct: 61  TNREPEFRLEETGPCSAILHADNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSGAI 120

Query: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFL-LDMATSVV 190
            Y+   AA  G IGISM  S P+V P GG E   GTNP+A AAP +G   L  DMAT+V 
Sbjct: 121 SYFVQQAARAGFIGISMCQSDPMVVPFGGAEIYYGTNPLAFAAPGEGDEILTFDMATTVQ 180

Query: 191 PIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSL 250
             GK+   R +   IP+ WA++  G  T    + F   +LLP         G KGYGL +
Sbjct: 181 AWGKVLDARSRNMSIPDTWAVDKNGVPT---TDPFAVHALLP-------AAGPKGYGLMM 230

Query: 251 MVDILSGILSGGTWSKHVKNTNE---KNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEI 307
           M+D+LSG+L G  + + V +  +      N+    + IN   F+  E F+  +S+ + E+
Sbjct: 231 MIDVLSGVLLGLPFGRQVSSMYDDLHAGRNLGQLHIVINPNFFSSSELFRQHLSQTMREL 290

Query: 308 KNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDEL 348
                 P F +++  G+   +        GI I   +   L
Sbjct: 291 NAITPAPGFNQVYYPGQDQDIKQRKAAVEGIEIVDDIYQYL 331


>sp|P30178|YBIC_ECOLI HYPOTHETICAL 38.9 KDA PROTEIN IN DING-GLNQ INTERGENIC REGION (O361)
           >gi|7449094|pir||A64817 malate dehydrogenase homolog
           ybiC - Escherichia coli >gi|1787020|gb|AAC73888.1|
           (AE000182) putative dehydrogenase [Escherichia coli K12]
           >gi|4062362|dbj|BAA35467.1| (D90717) Hypothetical 38.9
           kd protein in ding/rarB 3'region (o361). [Escherichia
           coli]
           Length = 361
           
 Score =  177 bits (444), Expect = 2e-43
 Identities = 123/349 (35%), Positives = 172/349 (49%), Gaps = 11/349 (3%)

Query: 13  RIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGI 72
           R     L SF+  V  ++G+ E++AK+VAD+LI A+L G +SHG+  +  YV     G +
Sbjct: 6   RFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHL 65

Query: 73  NLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAG 132
            ++   K ++E  +   LDGD  FGQV  ++AM L IEKA + GI  VA+ NS+H G  G
Sbjct: 66  QINHHAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIG 125

Query: 133 YYALMAAEEGMIGISMTN--SRPLVAPTGGVERILGTNPIALAAPTKGK-PFLLDMATSV 189
           Y+A   A  G + I   +    P+VAP  G +   GTNP  +  P K   P LLD ATS 
Sbjct: 126 YWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLDYATSA 185

Query: 190 VPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLS 249
           +  GK  V   KG  +P G  I+  G  T +   V     L  L  F E    HKGY L+
Sbjct: 186 IAFGKTRVAWHKGVPVPPGCLIDVNGVPTTN-PAVMQESPLGSLLTFAE----HKGYALA 240

Query: 250 LMVDILSGILSGG-TWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIK 308
            M +IL G LSGG T  +    T+      C   + IN E F   +      +E   E  
Sbjct: 241 AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPD--CNAQTEAFAEWV 298

Query: 309 NSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGV 357
            +  H D + I + GE    T   R K GIP+       + + AR++G+
Sbjct: 299 KASPHDDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAICDAARQIGM 347


>emb|CAB45039.1| (AL078635) putative carboxylic acid dehydrogenase [Amycolatopsis
           orientalis]
           Length = 337
           
 Score =  177 bits (444), Expect = 2e-43
 Identities = 114/339 (33%), Positives = 174/339 (50%), Gaps = 15/339 (4%)

Query: 18  ELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLHPR 77
           EL +   R+L   G+   DA+ VA +L+ +DL G +SHGV+R+  YV  I +G I+    
Sbjct: 7   ELEALATRILVAAGSSTVDAETVARSLVGSDLLGHDSHGVRRVIDYVKRIHTGLIDPRAE 66

Query: 78  IKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGYYALM 137
            K     P   ++ G   FGQ+   +A++  +      G G+  VR  NH G  G Y  M
Sbjct: 67  PKAETTRPGTVVVHGRRAFGQLAVRRAVRELLSLVPHQGSGVAVVRECNHIGRLGEYVAM 126

Query: 138 AAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAP--TKGKPFLLDMATSVVPIGKL 195
            A++ +IG++  N+ P VAP GG ER LGTNP+A A P      P ++D ATS +  GKL
Sbjct: 127 LADQDLIGLAFGNADPTVAPYGGRERRLGTNPLAWAVPRGPGQPPIVMDWATSGIAEGKL 186

Query: 196 EVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVDIL 255
            V R +GE++ EG  +++ G  + +  + + GG+LLP        GGHKGYGLS++++I+
Sbjct: 187 RVARDRGEQVAEGLVLDAAGRPSTTPADFYQGGALLP-------FGGHKGYGLSVLIEIV 239

Query: 256 SGILSG-GTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSRKHP 314
            G+LSG G  S  +    E    V    +A +I  F P+ EF+ +       +  +    
Sbjct: 240 GGLLSGIGIGS--MPGFREGWGTV---LVAFDIAAFLPVPEFRAQTERFCQALAETPLAE 294

Query: 315 DFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIAR 353
               + + GE        R + GIP+      ELN + R
Sbjct: 295 GASEVLVPGEPEERIRLERARDGIPVTANTWRELNALLR 333


>gb|AAA53657.1| (L02123) YbiC [Escherichia coli]
           Length = 361
           
 Score =  174 bits (436), Expect = 2e-42
 Identities = 122/349 (34%), Positives = 171/349 (48%), Gaps = 11/349 (3%)

Query: 13  RIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGI 72
           R     L SF+  V  ++ + E++AK+VAD+LI A+L G +SHG+  +  YV     G +
Sbjct: 6   RFDAQTLHSFIQAVFRQIPSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHL 65

Query: 73  NLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAG 132
            ++   K ++E  +   LDGD  FGQV  ++AM L IEKA + GI  VA+ NS+H G  G
Sbjct: 66  QINHHAKTVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIG 125

Query: 133 YYALMAAEEGMIGISMTN--SRPLVAPTGGVERILGTNPIALAAPTKGK-PFLLDMATSV 189
           Y+A   A  G + I   +    P+VAP  G +   GTNP  +  P K   P LLD ATS 
Sbjct: 126 YWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLDYATSA 185

Query: 190 VPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLS 249
           +  GK  V   KG  +P G  I+  G  T +   V     L  L  F E    HKGY L+
Sbjct: 186 IAFGKTRVAWHKGVPVPPGCLIDVNGVPTTN-PAVMQESPLGSLLTFAE----HKGYALA 240

Query: 250 LMVDILSGILSGG-TWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIK 308
            M +IL G LSGG T  +    T+      C   + IN E F   +      +E   E  
Sbjct: 241 AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPD--CNAQTEAFAEWV 298

Query: 309 NSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEIARRVGV 357
            +  H D + I + GE    T   R K GIP+       + + AR++G+
Sbjct: 299 KASPHDDDKPILLPGEWEVNTRRERQKQGIPLDAGSWQAICDAARQIGM 347


>gb|AAG22250.1| (AE003482) CG18808 gene product [Drosophila melanogaster]
           Length = 385
           
 Score =  171 bits (428), Expect = 1e-41
 Identities = 114/347 (32%), Positives = 169/347 (47%), Gaps = 10/347 (2%)

Query: 17  DELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLHP 76
           DE   F+   L ++G      + +++ L++AD RG    G+ RL  Y+  + SG   +  
Sbjct: 37  DEARRFIQDCLLRVGVSPSKVRCISEFLVVADYRGNYGSGLNRLDYYLSDLQSGHAKVGA 96

Query: 77  RIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGYYAL 136
              II E  S A ++G+   G  VG   M LA++KA  +GIG V  + S+  G+A ++  
Sbjct: 97  EPSIISETVSTAHVNGNSALGVFVGNFCMDLAVKKAEDSGIGFVVAQQSHDIGMASWFTF 156

Query: 137 MAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVPIGKLE 196
            AA +G+ GI M+NS P +         +G+N  A     +   F+LDMATSV  IG +E
Sbjct: 157 RAAGKGLAGIVMSNSAPTMMGPNSKSASIGSNCFAFCVKGEEYHFVLDMATSVKDIGAVE 216

Query: 197 VYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVDILS 256
                 E IP GWA N  G  T           L P        GGHKGY LS ++DIL 
Sbjct: 217 WAWANDEYIPHGWAANEGGLSTCFPSLALRTPLLFP-------AGGHKGYCLSAVIDILC 269

Query: 257 GILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSRKHPDF 316
           G+LSG  ++ H+     + SN+   F+A++ E F P   F  R  +    I+NS+   D 
Sbjct: 270 GVLSGAQYATHITMDQNQPSNLGQVFIALDPEFFLP--NFMERFDDFCGRIQNSQPADDS 327

Query: 317 ERIWIHGEKGFLTMETRLKLGIPIY-KKVLDELNEIARRVGVKGLEV 362
           E I + GE   + M     L    Y   +L +  E+A R+ VK +E+
Sbjct: 328 EPIRLPGELERMHMNYVEDLRALAYPNSLLTKYKEVAERLCVKPIEL 374


>sp|Q07251|LDH_ALCEU L-LACTATE DEHYDROGENASE >gi|2120947|pir||I39535 probable L-lactate
           dehydrogenase (EC 1.1.1.27) - Alcaligenes eutrophus
           >gi|311310|emb|CAA80432.1| (Z22737) lactate
           dehydrogenase [Ralstonia eutropha]
           Length = 349
           
 Score =  152 bits (380), Expect = 6e-36
 Identities = 93/244 (38%), Positives = 130/244 (53%), Gaps = 14/244 (5%)

Query: 26  VLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLHPRIKIIREGP 85
           +L     P + A  VA++L+ +D  G  SHG+  L  Y   +    +N   R K + +  
Sbjct: 15  ILAAQQVPADIADDVAEHLVESDRCGYISHGLSILPNYRTALDGHSVNPQGRAKCVLDQG 74

Query: 86  SYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGYYALMAAEEGMIG 145
           +  + DGD GFGQ VG   M+ AIE+ R+ G  IV +R S+H G  G+Y  MAA  G + 
Sbjct: 75  TLMVFDGDGGFGQHVGKSVMQAAIERVRQHGHCIVTLRRSHHLGRMGHYGEMAAAAGFVL 134

Query: 146 ISMT---NSRPLVAPTGGVERILGTNPIALAAPTKG--KPFLLDMATSVVPIGKLEVYRR 200
           +S T   N  P+VAP GG    L TNP+  A P      P ++D+ATS + I K  V   
Sbjct: 135 LSFTNVINRAPVVAPFGGRVARLTTNPLCFAGPMPNGRPPLVVDIATSAIAINKARVLAE 194

Query: 201 KGEEIPEGWAINSKGEITRSVEEVF--NGGSLLPLGGFGELLGGHKGYGLSLMVDILSGI 258
           KGE  PEG  I + G  T     +F  + G+LLP        GGHKGY L ++ ++L+G+
Sbjct: 195 KGEPAPEGSIIGADGNPTTDASTMFGEHPGALLP-------FGGHKGYALGVVAELLAGV 247

Query: 259 LSGG 262
           LSGG
Sbjct: 248 LSGG 251


>gb|AAF55744.1| (AE003729) CG17199 gene product [Drosophila melanogaster]
           Length = 461
           
 Score =  152 bits (379), Expect = 8e-36
 Identities = 105/349 (30%), Positives = 177/349 (50%), Gaps = 16/349 (4%)

Query: 22  FVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGGINLHPRIKII 81
           FV +V + +  P++ A  +AD LI AD  G  S G+ RL      +L+  +       I+
Sbjct: 104 FVSQVFSAMQVPKQAASEMADALIAADYMGQRSMGIHRLPSIAADLLNCTVAGDATPGIV 163

Query: 82  REGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIAGYYALMAAEE 141
            E  + AL+DG    G VV    M LA++KAR+ GIG V+ R+SN  G A +YA  A E+
Sbjct: 164 SEKKAIALVDGHNAPGPVVANFCMDLALQKAREVGIGWVSARSSNCIGFASWYACQALEQ 223

Query: 142 GMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVPIGKLEVYRRK 201
            MIG+ MTN+ P + P GG+E +LG NPIA AA    + F+ D   +   + +LE+    
Sbjct: 224 RMIGLCMTNAAPTLLPAGGIEPVLGENPIACAASGVHEQFVADFGMAACSVDELELSYCN 283

Query: 202 G--EEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVDILSGIL 259
           G  +E+P+  A++  G+ T S EE      +            HKG+GL+  VDIL G++
Sbjct: 284 GWSKEVPKLVALDRNGKETTSTEEALRAQRI------RAFQPEHKGFGLAAAVDILCGVM 337

Query: 260 SGGTWSKHVK-----NTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSRKHP 314
           +G  ++  ++     +T    +N+   ++AI+   F P   F+ R+++    ++ +    
Sbjct: 338 TGARYANQIQRRGVYSTENAPANLGQVYVAIDPMRFCP--TFEDRLADFHRLLRQAVPSK 395

Query: 315 DFERIWIHGEKGFLTME-TRLKLGIPIYKKVLDELNEIARRVGVKGLEV 362
             +   + G+K    M+    + G+ +    L  L E+A    ++ L++
Sbjct: 396 VGKPPMVPGDKELQHMKMVDEQGGLTMSSCTLSVLEELATEFDIEPLKM 444


>sp|P44995|YIAK_HAEIN HYPOTHETICAL PROTEIN HI1031 >gi|1074616|pir||C64165 hypothetical
           protein HI1031 - Haemophilus influenzae (strain Rd KW20)
           >gi|1574063|gb|AAC22691.1| (U32783) conserved
           hypothetical protein [Haemophilus influenzae Rd]
           Length = 332
           
 Score =  140 bits (349), Expect = 3e-32
 Identities = 101/344 (29%), Positives = 169/344 (48%), Gaps = 16/344 (4%)

Query: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71
           +R+  DEL +   RVL      EE A+  A         G  SHG+ R  R++  +  G 
Sbjct: 1   MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGD 60

Query: 72  I--NLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYG 129
           I  N  P  K++  G S    D  +  G +   K M  AIE A + G+G++A+RN+NH+ 
Sbjct: 61  IVPNAIPT-KVLSLG-SIEQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWM 118

Query: 130 IAGYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSV 189
             G Y   AAE+G IGI  TN+  ++ P G  E  +GTNP+ +A PT     ++DM+ S+
Sbjct: 119 RGGSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLIIAVPTT-PITMVDMSCSM 177

Query: 190 VPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLS 249
              G LEV+R  G +       + +G +TR    V     LLP+G +       KG GLS
Sbjct: 178 YSYGMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFW-------KGSGLS 230

Query: 250 LMVDILSGILSGGTWSKHVKNTNEKNSNVC--HFFMAINIEHFTPLEEFKGRMSEMINEI 307
           +++D+++ +LS G     V  T +KN   C    F+AI ++     +    +++ +++ +
Sbjct: 231 IVLDMIATLLSNG--ESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYV 288

Query: 308 KNSRKHPDFERIWIHGEKGFLTMETRLKLGIPIYKKVLDELNEI 351
           K + +    + + + G +    +      GIP+ ++V  +L  +
Sbjct: 289 KTAERSDPTQAVRLPGHEFTTILSDNQTNGIPVDERVWAKLKTL 332


>pir||S47796 hypothetical protein o332 - Escherichia coli
           >gi|466713|gb|AAB18552.1| (U00039) No definition line
           found [Escherichia coli]
           Length = 332
           
 Score =  137 bits (341), Expect = 2e-31
 Identities = 89/329 (27%), Positives = 157/329 (47%), Gaps = 8/329 (2%)

Query: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71
           +++  ++L +   RVL   G   E A   A+        G+ SHGV R  R++  + +G 
Sbjct: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60

Query: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131
           I    + K I    +    D     G +   K M  AIE A   GIG+VA+RN+NH+   
Sbjct: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120

Query: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVP 191
           G Y   AAE+G IGI  TNS  ++ P G  E  +GTNP+ +A P+     ++DM+ S+  
Sbjct: 121 GXYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST-PITMVDMSMSMFS 179

Query: 192 IGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLM 251
            G LEV R  G ++P     + +G +T+    +     +LP+G +       KG G+S++
Sbjct: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYW-------KGSGMSIV 232

Query: 252 VDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSR 311
           +D+++ +LS G     V   N     +   F+AI ++          ++  +++ + ++ 
Sbjct: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292

Query: 312 KHPDFERIWIHGEKGFLTMETRLKLGIPI 340
           +  + + I + G +    +    + GI +
Sbjct: 293 RADENQAIRLPGHEFTTLLAENRRNGITV 321


>sp|P37672|YIAK_ECOLI HYPOTHETICAL 36.6 KDA PROTEIN IN AVTA-SELB INTERGENIC REGION (O332)
           >gi|7449809|pir||A65157 hypothetical protein b3575 -
           Escherichia coli (strain K-12)
           >gi|1790000|gb|AAC76599.1| (AE000435) putative
           dehydrogenase [Escherichia coli K12]
           Length = 332
           
 Score =  136 bits (340), Expect = 3e-31
 Identities = 89/329 (27%), Positives = 157/329 (47%), Gaps = 8/329 (2%)

Query: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71
           +++  ++L +   RVL   G   E A   A+        G+ SHGV R  R++  + +G 
Sbjct: 1   MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD 60

Query: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131
           I    + K I    +    D     G +   K M  AIE A   GIG+VA+RN+NH+   
Sbjct: 61  IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG 120

Query: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAPTKGKPFLLDMATSVVP 191
           G Y   AAE+G IGI  TNS  ++ P G  E  +GTNP+ +A P+     ++DM+ S+  
Sbjct: 121 GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPST-PITMVDMSMSMFS 179

Query: 192 IGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLM 251
            G LEV R  G ++P     + +G +T+    +     +LP+G +       KG G+S++
Sbjct: 180 YGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYW-------KGSGMSIV 232

Query: 252 VDILSGILSGGTWSKHVKNTNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSR 311
           +D+++ +LS G     V   N     +   F+AI ++          ++  +++ + ++ 
Sbjct: 233 LDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAE 292

Query: 312 KHPDFERIWIHGEKGFLTMETRLKLGIPI 340
           +  + + I + G +    +    + GI +
Sbjct: 293 RADENQAIRLPGHEFTTLLAENRRNGITV 321


>pir||B83488 probable L-malate dehydrogenase PA1252 [imported] - Pseudomonas
           aeruginosa (strain PAO1)
           >gi|9947184|gb|AAG04641.1|AE004555_1 (AE004555) probable
           L-malate dehydrogenase [Pseudomonas aeruginosa]
           Length = 334
           
 Score =  133 bits (332), Expect = 3e-30
 Identities = 80/251 (31%), Positives = 120/251 (46%), Gaps = 9/251 (3%)

Query: 12  VRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLKRYVDGILSGG 71
           +R+  DE+    VR+L +    E   + VAD L+  +     SHG+ RL   +  + +G 
Sbjct: 2   IRMTLDEVRELAVRILRRHAFSEAHVQAVADTLVAGERDECASHGIWRLLGCIATLKAGK 61

Query: 72  INLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVAVRNSNHYGIA 131
           ++     ++    P    +D   GF Q      +   +EKAR  GI  +AV    H+   
Sbjct: 62  VSADAEPELHDIAPGLLRVDAHGGFSQCAFRLGLPHLLEKARSQGIAAMAVNRCVHFSAL 121

Query: 132 GYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAP-TKGKPFLLDMATSVV 190
                   E G++ ++ T S   VAP GG + I GTNPIA   P   G PF+ D ATS V
Sbjct: 122 WVEVEALTEAGLVALATTPSHAWVAPAGGRKPIFGTNPIAFGWPRPDGPPFVFDFATSAV 181

Query: 191 PIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSL 250
             G+++++ R G+ IP GW ++ +GE T        G  L          GGHKG  L+ 
Sbjct: 182 ARGEIQLHERAGKPIPLGWGVDEQGEPTTDASAALRGAML--------TFGGHKGSALAA 233

Query: 251 MVDILSGILSG 261
           MV++L+G L G
Sbjct: 234 MVELLAGPLIG 244


>pir||T20825 hypothetical protein F13D12.1 - Caenorhabditis elegans
           Length = 355
           
 Score = 88.5 bits (216), Expect = 1e-16
 Identities = 55/176 (31%), Positives = 94/176 (53%), Gaps = 16/176 (9%)

Query: 195 LEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGELLGGHKGYGLSLMVDI 254
           +E+  RK   +P  W +   G+ T    +V  GG LLPLGG  E+ GG+KGYGLS M++I
Sbjct: 22  VELAARKENPVPLSWGVGEGGKETTDPTKVLYGGGLLPLGGV-EVSGGYKGYGLSSMIEI 80

Query: 255 LSGILSGGTWSKHVKN--TNEKNSNVCHFFMAINIEHFTPLEEFKGRMSEMINEIKNSRK 312
             GIL+G  W  HV+   + +  +++   F+AI+ E F P   F  R+ + +  ++    
Sbjct: 81  FCGILAGAHWGPHVRKWMSTKSEADLGQCFVAIDPEAFAP--GFADRLQDFMQTMRALPT 138

Query: 313 HPDFERIWIHGEKGFLTMETRLKL------GIPIYKKVLDELNEIARRVGVKGLEV 362
                ++ + G+     ME R +       GIP +K  +  +N++A ++GVK +++
Sbjct: 139 SSPSFKVEVAGD-----MERRHEALVEQLGGIPYHKNQITFVNDLAAKLGVKTVDL 189


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.318    0.141    0.408 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 141535649
Number of Sequences: 2977
Number of extensions: 6471448
Number of successful extensions: 15109
Number of sequences better than 1.0e-10: 23
Number of HSP's better than  0.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 15029
Number of HSP's gapped (non-prelim): 23
length of query: 362
length of database: 189,106,746
effective HSP length: 55
effective length of query: 307
effective length of database: 156,189,961
effective search space: 47950318027
effective search space used: 47950318027
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 166 (69.1 bits)