BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1799 (PAB1799) DE:AMINO ACID TRANSPORTER
(425 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||D75130 amino acid transporter PAB1799 - Pyrococcus abyssi (... 815 0.0
pir||E71075 probable proton glutamate symport protein - Pyrococc... 749 0.0
pir||H72492 probable proton/sodium-glutamate symport protein APE... 505 e-142
gb|AAG20941.1| (AE005160) proton/sodium-glutamate symport protei... 343 2e-93
pir||F82503 proton/glutamate symporter VCA0088 [imported] - Vibr... 307 1e-82
dbj|BAB07539.1| (AP001520) H(+)/sodium-glutamate symporter [Baci... 302 4e-81
pir||A82962 proton-glutamate symporter PA5479 [imported] - Pseud... 294 2e-78
pir||D69635 H+/Na+-glutamate symport protein gltT - Bacillus sub... 280 1e-74
sp|P24943|GLTT_BACST PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN (GL... 276 4e-73
sp|P24944|GLTT_BACCA PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN (GL... 273 3e-72
pir||D71728 proton/sodium-glutamate symport protein (gltP) RP176... 272 4e-72
pir||B70415 proton/sodium-glutamate symport protein - Aquifex ae... 265 6e-70
pir||G72068 glutamate symport - Chlamydophila pneumoniae (strain... 262 5e-69
sp|P21345|GLTP_ECOLI PROTON GLUTAMATE SYMPORT PROTEIN (GLUTAMATE... 259 3e-68
pir||B75491 proton/sodium-glutamate symport protein - Deinococcu... 252 5e-66
pir||D71519 probable glutamate symport - Chlamydia trachomatis (... 250 2e-65
gb|AAF73590.1| (AE002337) sodium:dicarboxylate symporter family ... 249 5e-65
pir||G82777 glutamate symport protein XF0656 [imported] - Xylell... 248 1e-64
pir||C82232 proton/glutamate symporter VC1168 [imported] - Vibri... 238 1e-61
sp|P39817|GLTP_BACSU PROTON GLUTAMATE SYMPORT PROTEIN (GLUTAMATE... 231 9e-60
sp|Q01857|DCTA_RHILE C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|6285... 231 1e-59
pir||S71005 glutamate transport protein homolog - Saccharopolysp... 227 2e-58
emb|CAB77289.1| (AL160312) putative proton transport protein [St... 226 4e-58
gb|AAF27647.1|AF218211_2 (AF218211) GltP [Vibrio proteolyticus] 224 1e-57
pir||A33597 C4-dicarboxylate transport protein - Rhizobium melil... 224 2e-57
sp|P20672|DCTA_RHIME C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|1521... 224 2e-57
sp|P51907|EAT3_RAT EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-D... 224 2e-57
pir||C69771 C4-dicarboxylate transport protein homolog ydbH - Ba... 224 2e-57
dbj|BAA09849.1| (D63772) neuronal high affinity glutamate transp... 224 2e-57
pir||F82619 proton glutamate symport protein XF1937 [imported] -... 224 2e-57
gb|AAF34319.1|U21104_1 (U21104) neuronal glutamate transporter [... 223 3e-57
gb|AAB09773.1| (U39555) EAAC1 [Rattus norvegicus] 222 4e-57
emb|CAA70413.1| (Y09212) proton /sodium-glutamate symport protei... 221 1e-56
sp|P51906|EAT3_MOUSE EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM... 220 3e-56
sp|P50334|DCTA_SALTY C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|9930... 220 3e-56
gi|6678001 solute carrier family 1, member 1 [Mus musculus] >gi|... 220 3e-56
sp|P31601|DCTA_RHISN C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|1486... 218 9e-56
gb|AAF14541.2|AF167075_1 (AF167075) glutamate transporter [Canis... 218 1e-55
gb|AAB22401.1| (S38912) NGRDCTA2=47 kda C4-dicarboxylate transpo... 217 3e-55
gb|AAB22400.1| (S38912) NGRDCTA1=47.8 kda C4-dicarboxylate trans... 217 3e-55
sp|P24942|EAT1_RAT EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-D... 216 3e-55
gi|9507115 solute carrier family 1, member 3 [Rattus sp.] >gi|21... 216 3e-55
prf||1922355A Glu transporter [Mus musculus] 216 3e-55
sp|P56564|EAT1_MOUSE EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM... 216 3e-55
sp|Q95135|EAT3_BOVIN EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM... 216 4e-55
sp|P31597|EAT3_RABIT EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM... 215 6e-55
sp|P37312|DCTA_ECOLI C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|1073... 215 6e-55
gi|4759126 solute carrier family 1 (glial high affinity glutamat... 215 7e-55
gb|AAD45401.1|AF067847_1 (AF067847) Na+-dependent glutamate tran... 215 7e-55
sp|P46411|EAT1_BOVIN EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM... 215 1e-54
pir||D75262 C4-dicarboxylate transport protein - Deinococcus rad... 214 1e-54
pir||D83498 C4-dicarboxylate transport protein PA1183 [imported]... 214 1e-54
pir||I38560 glutamate transporter - human >gi|507898|gb|AAA68628... 214 2e-54
gb|AAF71701.1|AF208521_1 (AF208521) high-affinity Na+-dependent ... 213 2e-54
gb|AAC27511.3| (AF074911) neuronal and epithelial glutamate tran... 213 3e-54
gi|4759122 solute carrier family 1 (neuronal/epithelial high aff... 212 8e-54
pir||T29633 hypothetical protein C12D12.2 - Caenorhabditis elega... 212 8e-54
sp|Q10901|EAT1_CAEEL EXCITATORY AMINO ACID TRANSPORTER (SODIUM-D... 212 8e-54
sp|O57321|EAT1_AMBTI EXCITATORY AMINO ACID TRANSPORTER 1 (SEAAT1... 212 8e-54
sp|P43005|EAT3_HUMAN EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM... 212 8e-54
emb|CAB40566.1| (AJ132912) putative C-4-dicarboxylate carrier [R... 210 3e-53
pir||S38353 glutamate transporter protein - human 209 4e-53
gb|AAB41909.1| (U35250) CeGlt-2 [Caenorhabditis elegans] 208 7e-53
gb|AAB41910.1| (U35250) CeGlt-1 [Caenorhabditis elegans] 208 7e-53
pir||A54856 high affinity glutamate transporter - human >gi|5170... 208 7e-53
sp|Q25605|EAT_ONCVO EXCITATORY AMINO ACID TRANSPORTER (SODIUM-DE... 206 3e-52
sp|P31596|EAT2_RAT EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM-D... 206 5e-52
gb|AAA93061.1| (U15098) GluT [Rattus norvegicus] 206 5e-52
gb|AAG13411.1|AF297648_1 (AF297648) sodium-dependent high affini... 206 5e-52
pir||T27128 hypothetical protein Y53C12A.2 - Caenorhabditis eleg... 206 5e-52
gb|AAA19438.1| (L19444) neutral amino acid transporter [Homo sap... 205 1e-51
gi|11430506 solute carrier family 1 (glutamate/neutral amino aci... 205 1e-51
dbj|BAA94861.1| (AB026689) hASCT1 [Homo sapiens] 205 1e-51
gi|4506995 solute carrier family 1 (glutamate/neutral amino acid... 204 2e-51
gi|9256644 neutral amino acid transporter [Mus musculus] >gi|302... 203 3e-51
gb|AAG02179.1|AF246129_1 (AF246129) neutral amino acid transport... 203 3e-51
gb|AAB84380.1| (AF003006) high-affinity Na+-dependent glutamate ... 202 6e-51
sp|P43006|EAT2_MOUSE EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM... 202 6e-51
dbj|BAA23771.1| (AB007811) mGLT-1A [Mus musculus] 202 6e-51
gi|7106409 solute carrier family 1, member 2; glial high affinit... 202 6e-51
pir||JV0092 glutamate-aspartate carrier protein - Escherichia coli 202 6e-51
gb|AAA23832.1| (M32488) glutamate and aspartate carrier (gltP) [... 202 7e-51
sp|Q22682|EAT4_CAEEL PUTATIVE SODIUM-DEPENDENT EXCITATORY AMINO ... 201 9e-51
gb|AAB71737.1| (U75372) glutamate transporter [Mus musculus] 201 9e-51
pir||JC4262 glutamate transporter 2 - mouse >gi|882343|gb|AAA916... 201 9e-51
gi|10835252 solute carrier family 1 (glutamate transporter), mem... 200 2e-50
prf||2206275A neuronal Glu transporter EAAC1 [Rattus norvegicus] 200 2e-50
gb|AAF14542.2|AF167076_1 (AF167076) glutamate transporter [Canis... 200 2e-50
emb|CAB72412.1| (AL138978) putative sodium:dicarboxylate symport... 200 2e-50
sp|P43004|EAT2_HUMAN EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM... 200 3e-50
emb|CAC10342.1| (AL133330) dJ68D18.1.2 (solute carrier family 1 ... 200 3e-50
emb|CAC10343.1| (AL133330) dJ68D18.1.1 (solute carrier family 1 ... 200 3e-50
gi|11435951 solute carrier family 1 (glial high affinity glutama... 200 3e-50
gi|6678003 solute carrier family 1, member 6 [Mus musculus] >gi|... 199 5e-50
emb|CAA10803.1| (AJ132846) sodium-dependent neutral amino acid t... 199 6e-50
pir||I38399 glutamate/aspartate transporter II - human >gi|49825... 198 8e-50
gb|AAB88287.1| (AF018257) glutamate transporter 2A [Ambystoma ti... 198 1e-49
gi|4759124 solute carrier family 1 (glial high affinity glutamat... 197 2e-49
sp|Q15758|AAAT_HUMAN NEUTRAL AMINO ACID TRANSPORTER B(0) (ATB(0)... 197 2e-49
gi|4827012 solute carrier family 1 (high affinity aspartate/glut... 197 2e-49
pir||E82740 C4-dicarboxylate transport protein XF0976 [imported]... 196 3e-49
sp|O35921|EAT4_RAT EXCITATORY AMINO ACID TRANSPORTER 4 (SODIUM-D... 196 3e-49
gb|AAB88290.1| (AF018260) glutamate transporter 5B [Ambystoma ti... 196 4e-49
gb|AAD09814.1| (AF105230) neutral amino acid transporter [Homo s... 196 4e-49
gi|5032093 solute carrier family 1 (neutral amino acid transport... 196 4e-49
sp|O19105|AAAT_RABIT NEUTRAL AMINO ACID TRANSPORTER B(0) (ATB(0)... 195 7e-49
gb|AAG02180.1|AF246130_1 (AF246130) neutral amino acid transport... 193 3e-48
gb|AAD09812.1| (AF102826) RD114/simian type D retrovirus recepto... 193 4e-48
gb|AAB88288.1| (AF018258) glutamate transporter 2B [Ambystoma ti... 192 5e-48
gb|AAD09142.1| (AF001784) sodium-dependent glutamate transporter... 192 5e-48
gi|8394286 solute carrier family 1, member 2 [Rattus norvegicus]... 192 8e-48
gb|AAB88289.1| (AF018259) glutamate transporter 5A [Ambystoma ti... 191 1e-47
gb|AAF73069.1|AF265360_1 (AF265360) GLAST-1a [Rattus norvegicus] 189 5e-47
pir||H83629 probable dicarboxylate transporter PA0119 [imported]... 188 1e-46
pir||A47131 Na+-dependent neutral amino acid transporter SATT - ... 186 4e-46
pir||A70681 probable dctA protein - Mycobacterium tuberculosis (... 185 8e-46
gb|AAD22406.1|AF079997_3 (AF079997) DctA [Pseudomonas putida] 183 3e-45
gi|11429149 solute carrier family 1 (neuronal/epithelial high af... 182 5e-45
gb|AAD47830.1|AF166000_1 (AF166000) sodium-dependent excitatory ... 180 2e-44
gb|AAF51466.1| (AE003588) Eaat2 gene product [Drosophila melanog... 180 2e-44
emb|CAC12702.1| (AL136231) bA6J24.1 (solute carrier family 1 (ne... 180 2e-44
sp|P77529|YDJN_ECOLI HYPOTHETICAL SYMPORTER YDJN >gi|7451170|pir... 178 8e-44
gb|AAB71739.1| (U75214) mEAAC2 [Mus musculus] 177 2e-43
pir||B81325 probable C4-dicarboxylate transport protein Cj1192 [... 176 4e-43
gb|AAD34586.1|AF144379_1 (AF144379) glutamate transporter Am-EAA... 175 7e-43
gb|AAF14543.2|AF167077_1 (AF167077) glutamate transporter [Canis... 170 2e-41
sp|P54596|YHCL_BACSU HYPOTHETICAL SYMPORTER YHCL >gi|7451171|pir... 169 5e-41
gb|AAB32664.1| (S75687) glutamate/aspartate transporter, GLAST [... 167 2e-40
pir||D81418 probable transmembrane symporter Cj0025c [imported] ... 166 3e-40
gb|AAA93062.1| (U15098) GluT-R glutamate transporter [Rattus nor... 166 6e-40
sp|P45079|YDJN_HAEIN HYPOTHETICAL SYMPORTER HI1154 >gi|1075186|p... 162 5e-39
pir||F82223 sodium/dicarboxylate symporter VC1235 [imported] - V... 160 3e-38
sp|Q21751|EAT3_CAEEL PUTATIVE SODIUM-DEPENDENT EXCITATORY AMINO ... 158 1e-37
pir||C83391 probable transporter (membrane subunit) PA2042 [impo... 151 1e-35
pir||H70190 glutamate transporter (gltP) homolog - Lyme disease ... 150 3e-35
pir||D81313 probable transmembrane transport protein Cj1097 [imp... 148 1e-34
sp|P42602|YGJU_ECOLI HYPOTHETICAL SYMPORTER YGJU >gi|7466002|pir... 147 2e-34
pir||F81003 sodium/dicarboxylate symporter family protein NMB213... 145 7e-34
pir||B82025 probable symport protein NMA0298 [imported] - Neisse... 145 1e-33
gi|11423908 solute carrier family 1 (glutamate transporter), mem... 143 5e-33
dbj|BAA85981.1| (AB034153) unnamed protein product [Shewanella v... 142 8e-33
sp|P45246|YGJU_HAEIN HYPOTHETICAL SYMPORTER HI1545 >gi|1073914|p... 138 1e-31
pir||B82509 sodium/dicarboxylate symporter VCA0036 [imported] - ... 137 2e-31
pir||E72095 neutral amino acid (glutamate) transporter - Chlamyd... 129 5e-29
gb|AAF73673.1| (AE002208) sodium:dicarboxylate symporter family ... 129 5e-29
pir||T34005 hypothetical protein W03G1.1 - Caenorhabditis elegan... 129 8e-29
gb|AAF73565.1| (AE002318) sodium:dicarboxylate symporter family ... 120 2e-26
pir||B71541 probable amino acid (glutamate) transporter - Chlamy... 120 4e-26
gb|AAC46376.1| (AF017105) amino acid transporter [Chlamydophila ... 119 5e-26
pir||G71309 probable glutamate/ aspartate transporter - syphilis... 80 4e-14
gb|AAB71742.1| (U75217) glutamate transporter mEAAC1 [Mus musculus] 72 1e-11
>pir||D75130 amino acid transporter PAB1799 - Pyrococcus abyssi (strain Orsay)
>gi|5458268|emb|CAB49757.1| (AJ248285) AMINO ACID
TRANSPORTER [Pyrococcus abyssi]
Length = 425
Score = 815 bits (2083), Expect = 0.0
Identities = 425/425 (100%), Positives = 425/425 (100%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP
Sbjct: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK
Sbjct: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
Query: 121 QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA
Sbjct: 121 QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
Query: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA 240
ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA
Sbjct: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA 240
Query: 241 LQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYS 300
LQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYS
Sbjct: 241 LQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYS 300
Query: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA
Sbjct: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
Query: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELK 420
IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELK
Sbjct: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELK 420
Query: 421 EGIIY 425
EGIIY
Sbjct: 421 EGIIY 425
>pir||E71075 probable proton glutamate symport protein - Pyrococcus horikoshii
>gi|3257716|dbj|BAA30399.1| (AP000005) 425aa long
hypothetical proton glutamate symport protein
[Pyrococcus horikoshii]
Length = 425
Score = 749 bits (1913), Expect = 0.0
Identities = 385/424 (90%), Positives = 409/424 (95%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
MG +KY+E+PVLQKILIGLILGAIVGLILGHYGYADAVKTY+KPFGDLFVRLLKMLVMP
Sbjct: 1 MGLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMP 60
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMAR+FNPGAGI LA G+
Sbjct: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQ 120
Query: 121 QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
QFQPKQAPPLV+ LL+I+PTNPFGALANG+VLPTIFFAI+LGIAITYLMNS++E+VRKSA
Sbjct: 121 QFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSA 180
Query: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA 240
ETLL+AINGLAEAMYKIV GVMQYAPIGVFALIA VMA QGVKVVGELAKVT AVYVGL
Sbjct: 181 ETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLT 240
Query: 241 LQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYS 300
LQILLVYFVLLK++GIDPI FI KAKDAMLTAFVTRSSSGTLPVTMRVA++MGIS+GIYS
Sbjct: 241 LQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYS 300
Query: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
FTLPLGATINMDGTALYQGVCTFFIANALG HLT+GQQLTIVLTAVLASIGTAGVPGAGA
Sbjct: 301 FTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGA 360
Query: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELK 420
IMLAMVLESVGLPLTD NVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL+
Sbjct: 361 IMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELE 420
Query: 421 EGII 424
+G+I
Sbjct: 421 KGVI 424
>pir||H72492 probable proton/sodium-glutamate symport protein APE2583 -
Aeropyrum pernix (strain K1) >gi|5106289|dbj|BAA81600.1|
(AP000064) 421aa long hypothetical
proton/sodium-glutamate symport protein [Aeropyrum
pernix]
Length = 421
Score = 505 bits (1287), Expect = e-142
Identities = 259/422 (61%), Positives = 323/422 (76%), Gaps = 9/422 (2%)
Query: 5 KKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFA 64
++Y+E PVL KI +G +LG I G+++G V +KP GDLF+RLLKMLV PIVF
Sbjct: 3 RRYIEIPVLYKIAVGFVLGIIAGIVIG------GVMVDLKPLGDLFIRLLKMLVAPIVFF 56
Query: 65 SLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQP 124
SL VGAASIS + LGRVGVKI VYYL T+AFA+T+G+I+A I PG G+ LA K+ Q
Sbjct: 57 SLAVGAASISASLLGRVGVKIFVYYLFTTAFAITIGLIVANIIQPGRGLELAGEAKEIQV 116
Query: 125 KQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLL 184
K PP+ + LLNI+PTNPF ALA G VL IFFAIVLG+A+ L +S+D+R+R ET+
Sbjct: 117 KPPPPISEVLLNIVPTNPFKALAEGNVLQIIFFAIVLGVAVALLRSSRDDRLRSGGETVY 176
Query: 185 NAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQIL 244
+GLAE+MYKIV GV++YAPIGVFALI V+A+ G V+G LA V + +Y+GLA+ +L
Sbjct: 177 RVFDGLAESMYKIVRGVLEYAPIGVFALIGYVVATAGPGVLGPLAVVVITLYIGLAIHVL 236
Query: 245 LVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVA-EDMGISKGIYSFTL 303
VY ++L++FG P+KF A +AM TAFVTRSSSGTLPVTM+VA E++ I + I+SFTL
Sbjct: 237 GVYSLILRLFGFSPLKFFKGALEAMATAFVTRSSSGTLPVTMKVAEEELAIDRRIFSFTL 296
Query: 304 PLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIML 363
PLGATINMDGTA+YQ V FIAN LG+ L++GQQL+I+L A LASIGTAGVPGAG IML
Sbjct: 297 PLGATINMDGTAMYQAVAALFIANTLGIDLSIGQQLSIILAATLASIGTAGVPGAGLIML 356
Query: 364 AMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEG--ELKE 421
A+VLE++GL LTD VA AY +I GID ILDMGRTMVNVTGDL GT IVAKTE + K+
Sbjct: 357 AIVLEALGLSLTDPTVALAYGLIAGIDVILDMGRTMVNVTGDLVGTTIVAKTENAVDTKK 416
Query: 422 GI 423
G+
Sbjct: 417 GV 418
>gb|AAG20941.1| (AE005160) proton/sodium-glutamate symport protein; GltP
[Halobacterium sp. NRC-1]
Length = 491
Score = 343 bits (871), Expect = 2e-93
Identities = 185/413 (44%), Positives = 266/413 (63%), Gaps = 21/413 (5%)
Query: 7 YLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASL 66
Y ++ +I + +LG++ GL +G A ++P G LFVRLLKM+++P+V +L
Sbjct: 76 YRSVAIIYRIAVAFVLGSVCGLAVG------APAAQLEPLGTLFVRLLKMIIIPVVVFTL 129
Query: 67 VVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQ 126
++GA +SP R+G++G +++ YL T+A A+ +G++ + NPG G+ +A+A + Q
Sbjct: 130 LMGARQLSPTRIGKIGGEVIALYLGTTAVAIAIGLLAGNLINPGVGLEVADAA--VETTQ 187
Query: 127 APPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDER--VRKSAETLL 184
AP L L+N++PTNP GA+ANG VLPTIFF I LGI+ L + + V A+ +
Sbjct: 188 APDLGTVLMNVVPTNPIGAMANGDVLPTIFFTIALGISFAILQDEFEPGTPVHDGAQAVF 247
Query: 185 NAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQIL 244
+EAM+ +V GVM+Y IGVFAL+A GV + AK+ A+ + + L I
Sbjct: 248 KIAEAGSEAMFNVVWGVMEYGVIGVFALMATTFGEAGVDAILPFAKLIGALALAVVLHIG 307
Query: 245 LVYFVLLKVFGI---DPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVA-EDMGISKGIYS 300
+ Y +++ +G+ P F++ AK+AM+TA RSSSGTLPVTM A E+ GI + +YS
Sbjct: 308 VTYLFVIQ-WGLLRESPRAFLAGAKEAMVTALSIRSSSGTLPVTMNNADENFGIDEEVYS 366
Query: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
F+LPLGATINMDGTA+YQGV F AN +G LTL +Q T+++TA+LAS+GTAGVPG+G
Sbjct: 367 FSLPLGATINMDGTAMYQGVAAIFAANLVGQTLTLAEQATVIVTALLASVGTAGVPGSGL 426
Query: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVA 413
IML +VL +GLPL M+ G+D ILD RTM NVTGDL T +VA
Sbjct: 427 IMLTLVLTQLGLPL------EVVGMVAGVDPILDRLRTMNNVTGDLAVTTLVA 473
>pir||F82503 proton/glutamate symporter VCA0088 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657473|gb|AAF96002.1|
(AE004351) proton/glutamate symporter [Vibrio cholerae]
Length = 424
Score = 307 bits (779), Expect = 1e-82
Identities = 176/430 (40%), Positives = 253/430 (57%), Gaps = 24/430 (5%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGL----ILGHYGYADA--VKTYIKPFGDLFVRLL 54
M W+ + K+++G++ G + G + G+ DA V G +F+ L
Sbjct: 1 MFWMNTKKPLSLTAKVILGMVAGILTGFAIRALFAGNGFVDAYIVNGLFDVGGKIFIASL 60
Query: 55 KMLVMPIVFASLVVGAASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI 113
KMLV+P+VF SLV G +S+ + LGR+G K + +YL T+A A+TL + M +F PGAG
Sbjct: 61 KMLVVPLVFVSLVCGTSSLKDLSTLGRMGSKTLGFYLATTAIAITLALTMGSLFQPGAGA 120
Query: 114 TLAEAGKQFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKD 173
L A F +AP L + ++++ PTNP A+A G L I FA++ G+AI+
Sbjct: 121 DLT-AASNFTSAEAPSLGKVIVDMFPTNPISAMAQGNTLQIIIFAVLFGVAIS------- 172
Query: 174 ERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTV 233
K E + N L E + K+VA +M AP GVF L+A + G+ + LA+ V
Sbjct: 173 -AAGKPGERIAQVFNDLNEVIMKLVAMLMHLAPYGVFFLMAKLFTGLGLGAILNLAEYFV 231
Query: 234 AVYVGLALQILLVYFVLLKVF-GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED- 291
+ L L + Y ++LK F G++P+ F K +DA++ AF T SS+ T+PVTM ++
Sbjct: 232 VLAGTLLLHAFVTYGLMLKTFAGLNPMVFFRKMEDAIMFAFSTASSNATIPVTMETVKNR 291
Query: 292 MGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIG 351
+G+ + SFT+PLGAT+NMDGTA+ QGV T FIA A + LT+ L ++LTA LAS+G
Sbjct: 292 LGVDNKVASFTVPLGATVNMDGTAIMQGVATAFIAQAFNIDLTMTDYLMVILTATLASVG 351
Query: 352 TAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAI 411
TAGVPG G +MLAMVL VGLPL A+I+G+D +LDM RT VN+TGD + I
Sbjct: 352 TAGVPGVGLVMLAMVLNQVGLPL------EGIALIMGVDRLLDMIRTAVNITGDACVSCI 405
Query: 412 VAKTEGELKE 421
VAK+E E
Sbjct: 406 VAKSENAFDE 415
>dbj|BAB07539.1| (AP001520) H(+)/sodium-glutamate symporter [Bacillus halodurans]
Length = 413
Score = 302 bits (766), Expect = 4e-81
Identities = 170/413 (41%), Positives = 255/413 (61%), Gaps = 20/413 (4%)
Query: 14 QKILIGLILGAIVGLILGHYG--YADAVKTYI-KPFGDLFVRLLKMLVMPIVFASLVVGA 70
+KI+I L+LG +VGL + + + TY+ P G LF+RL+ MLV+P+V S+++G
Sbjct: 5 KKIIIALVLGILVGLGMNKFAPDLFVPIDTYVFTPVGQLFLRLIMMLVVPLVLFSIILGT 64
Query: 71 ASIS-PARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPP 129
A + P +LG++G K V +YLLT+ A+ +G+ +A + PG + ++F+ +APP
Sbjct: 65 AGLGDPKKLGKLGSKTVGFYLLTTMIALVIGLSIAYVLQPGEPGLMGTVEEEFEATEAPP 124
Query: 130 LVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAING 189
+++T+LNIIP NP ALA+G++L I FA+++G+A+ R+ + +L +
Sbjct: 125 VMETILNIIPRNPIEALASGQMLQIIAFAVLVGLALG--------RLGEKTSGILKLVEQ 176
Query: 190 LAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFV 249
E M +V+ M+ AP G F LIA+ + G +G +A +AV + L L ++ Y
Sbjct: 177 GNEVMMYLVSLAMKLAPYGAFGLIASALGKLGFDALGSMAMYVIAVLLALLLHAVITYGG 236
Query: 250 LLK-VFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
L V +P++F+ AM AF T SSS LPV+M+ A++ +G+SK + SF PLGA
Sbjct: 237 FLAFVAKRNPLEFLRNFFPAMALAFGTSSSSAVLPVSMKTAQEKLGVSKPVSSFVQPLGA 296
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTA+ Q V T FIA L++G LT+VLTA LASIGTAGVPG G IMLAMVL
Sbjct: 297 TINMDGTAIMQAVATVFIAQVYAQQLSMGDLLTVVLTATLASIGTAGVPGVGLIMLAMVL 356
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELK 420
+S+GLP+ A++L +D ILDM RT +N+TGD T ++ ++E K
Sbjct: 357 QSIGLPV------EGIALVLAVDRILDMSRTAINITGDATCAVVIDESEKRSK 403
>pir||A82962 proton-glutamate symporter PA5479 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951812|gb|AAG08864.1|AE004960_7 (AE004960)
proton-glutamate symporter [Pseudomonas aeruginosa]
Length = 444
Score = 294 bits (744), Expect = 2e-78
Identities = 158/415 (38%), Positives = 249/415 (59%), Gaps = 25/415 (6%)
Query: 15 KILIGLILGAIVGLILGHYGYADA--VKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAAS 72
+I+IGL LG VG +L H+ A + ++P GD+F+RL+KM+V+PIV +SLVVG A
Sbjct: 11 QIVIGLALGIAVGAVLNHFSAEKAWWIANVLQPAGDIFIRLIKMIVVPIVISSLVVGIAG 70
Query: 73 ISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG----KQFQP--- 124
+ A+ LGR+G+K ++Y+ + + A+ +G+++A +F PG GI ++ G Q+Q
Sbjct: 71 VGDAKKLGRIGLKTIIYFEIVTTVAIVVGLLLANLFQPGTGIDMSTLGTVDISQYQKTTQ 130
Query: 125 --KQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
+ + T+LN+IP+N F A+A G++LP IFF+++ G+ ++ L N E
Sbjct: 131 EVQHDHAFIATILNLIPSNVFAAIARGEMLPIIFFSVMFGLGLSSLPNDL-------REP 183
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
L+ G++E M+K+ +M+YAPIGVFALIA +A+ G + LAK+ + VYV +
Sbjct: 184 LVKVFQGVSETMFKVTHMIMKYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAIVFF 243
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
L+V ++ ++FG ++ I KD ++ A+ T SS LP + E G K I SF
Sbjct: 244 ALVVLGLIARMFGFSIMRLIRIFKDDLVLAYSTASSETVLPRIIEKMEAYGAPKAISSFV 303
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DG+ LYQ + FIA G+ L++GQQ+ +VLT ++ S G AGVPG ++
Sbjct: 304 VPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIGQQIMLVLTLMVTSKGIAGVPGVSFVV 363
Query: 363 LAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEG 417
L L SVG+PL A I G+D I+DM RT +NV G+ +++K EG
Sbjct: 364 LLATLGSVGIPL------EGLAFIAGVDRIMDMARTALNVIGNALAVLVISKWEG 412
>pir||D69635 H+/Na+-glutamate symport protein gltT - Bacillus subtilis
>gi|2226240|emb|CAA74528.1| (Y14083) Hypothetical
protein [Bacillus subtilis] >gi|2633358|emb|CAB12862.1|
(Z99109) proton/sodium-glutamate symport protein
[Bacillus subtilis]
Length = 429
Score = 280 bits (710), Expect = 1e-74
Identities = 156/421 (37%), Positives = 252/421 (59%), Gaps = 26/421 (6%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFAS 65
K ++F + +I +GLILG IVG+I YG A+ TY++P GDLF+RL+KM+V+PIV +S
Sbjct: 2 KRIKFGLATQIFVGLILGVIVGVIW--YGNP-ALPTYLQPIGDLFLRLIKMIVIPIVVSS 58
Query: 66 LVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK---- 120
L++G A + +G++G + ++Y+ + + FA+ LG+ +A IF+PG G+ + EA K
Sbjct: 59 LIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFHPGTGVNIHEAQKSDIS 118
Query: 121 ---QFQPKQAPPLV-QTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERV 176
+ + +Q+ V +T L+I+PTN F +L G +L I F ++ + I+ +
Sbjct: 119 QYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFTVLFALGIS--------AI 170
Query: 177 RKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVY 236
+ + +L G++ AM+ +V VM+ AP GVFALI ++ G+ + L K+ VY
Sbjct: 171 GERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGSLISLGKLVGLVY 230
Query: 237 VGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISK 296
V LA +++++ ++ K+ GI KF++ KD +L AF T SS LP M E +G K
Sbjct: 231 VALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVLPRIMEKMEKIGCPK 290
Query: 297 GIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVP 356
GI SF +P+G T N+DG+ LYQ + F+A G+ LT+ Q+T+VL ++ S G A VP
Sbjct: 291 GIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQITLVLVLMVTSKGMAAVP 350
Query: 357 GAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 416
G ++L L ++G+P A A I G+D I+DM RT+VN+TG+ +++K E
Sbjct: 351 GTSFVVLLATLGTIGVP------AEGLAFIAGVDRIMDMARTVVNLTGNALAAVVMSKWE 404
Query: 417 G 417
G
Sbjct: 405 G 405
>sp|P24943|GLTT_BACST PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE
CARRIER PROTEIN) >gi|282381|pir||S26247
glutamate/aspartate transport protein [validated] -
Bacillus stearothermophilus >gi|143000|gb|AAA22492.1|
(M86508) proton glutamate symport protein [Bacillus
stearothermophilus]
Length = 421
Score = 276 bits (698), Expect = 4e-73
Identities = 155/416 (37%), Positives = 238/416 (56%), Gaps = 26/416 (6%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+I IGLILG IVG I YG V TY++P GD+F+RL+KM+V+PIV +SLVVG AS+
Sbjct: 9 QIFIGLILGIIVGAIF--YGNPK-VATYLQPIGDIFLRLIKMIVIPIVISSLVVGVASVG 65
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ--------FQPK 125
+ LG++G K ++Y+ + + A+ +G++ A IF PG G+ + K
Sbjct: 66 DLKKLGKLGGKTIIYFEIITTIAIVVGLLAANIFQPGTGVNMKSLEKTDIQSYVDTTNEV 125
Query: 126 QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
Q +V+T +NI+P N F +L G +LP IFF+++ G+ + + + + +L
Sbjct: 126 QHHSMVETFVNIVPKNIFESLTKGDMLPIIFFSVMFGLGVA--------AIGEKGKPVLQ 177
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILL 245
G AEAM+ + +M++AP GVFALI ++ GV+ + L+K+ + VY + I +
Sbjct: 178 FFQGTAEAMFYVTNQIMKFAPFGVFALIGVTVSKFGVESLIPLSKLVIVVYATMVFFIFV 237
Query: 246 VYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPL 305
V + K+FGI+ I KD ++ A+ T SS LP M E+ G K I SF +P
Sbjct: 238 VLGGVAKLFGINIFHIIKILKDELILAYSTASSETVLPKIMEKMENFGCPKAITSFVIPT 297
Query: 306 GATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAM 365
G + N+DG+ LYQ + FIA G+ + + QQ++++L ++ S G AGVPG ++L
Sbjct: 298 GYSFNLDGSTLYQALAAIFIAQLYGIDMPISQQISLLLVLMVTSKGIAGVPGVSFVVLLA 357
Query: 366 VLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
L +VG+P+ A I GID ILDM RT VNV G+ I++K EG+ E
Sbjct: 358 TLGTVGIPI------EGLAFIAGIDRILDMARTAVNVIGNSLAAIIMSKWEGQYNE 407
>sp|P24944|GLTT_BACCA PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE
CARRIER PROTEIN) >gi|282347|pir||S26246
glutamate/aspartate transport protein - Bacillus
caldotenax >gi|143002|gb|AAA22493.1| (M86509) proton
glutamate symport protein [Bacillus caldotenax]
Length = 421
Score = 273 bits (690), Expect = 3e-72
Identities = 155/416 (37%), Positives = 238/416 (56%), Gaps = 26/416 (6%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+I IGLILG IVG I YG V Y++P GD+F+RL+KM+V+PIV +SLVVG AS+
Sbjct: 9 QIFIGLILGIIVGAIF--YGNPK-VAAYLQPIGDIFLRLIKMIVIPIVISSLVVGVASVG 65
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ--------FQPK 125
+ LG++G K ++Y+ + + A+ +G++ A IF PGAG+ + K
Sbjct: 66 DLKKLGKLGGKTIIYFEIITTIAIVVGLLAANIFQPGAGVNMKSLEKTDIQSYVDTTNEV 125
Query: 126 QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
Q +V+T +NI+P N F +L+ G +LP IFF+++ G+ + + + + +L
Sbjct: 126 QHHSMVETFVNIVPKNIFESLSTGDMLPIIFFSVMFGLGVA--------AIGEKGKPVLQ 177
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILL 245
G AEAM+ + +M++AP GVFALI ++ GV+ + L+K+ + VY + I
Sbjct: 178 FFQGTAEAMFYVTNQIMKFAPFGVFALIGVTVSKFGVESLIPLSKLVIVVYATMLFFIFA 237
Query: 246 VYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPL 305
V + K+FGI+ I KD ++ A+ T SS LP M E G K I SF +P
Sbjct: 238 VLGGVAKLFGINIFHIIKILKDELILAYSTASSETVLPRIMDKMEKFGCPKAITSFVIPT 297
Query: 306 GATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAM 365
G + N+DG+ LYQ + FIA G+ +++ QQ++++L ++ S G AGVPG ++L
Sbjct: 298 GYSFNLDGSTLYQALAAIFIAQLYGIDMSVSQQISLLLVLMVTSKGIAGVPGVSFVVLLA 357
Query: 366 VLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
L +VG+P+ A I GID ILDM RT VNV G+ I++K EG+ E
Sbjct: 358 TLGTVGIPV------EGLAFIAGIDRILDMARTAVNVIGNSLAAIIMSKWEGQYNE 407
>pir||D71728 proton/sodium-glutamate symport protein (gltP) RP176 - Rickettsia
prowazekii >gi|3860742|emb|CAA14643.1| (AJ235270)
PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN (gltP)
[Rickettsia prowazekii]
Length = 399
Score = 272 bits (689), Expect = 4e-72
Identities = 162/413 (39%), Positives = 242/413 (58%), Gaps = 24/413 (5%)
Query: 14 QKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASI 73
QK+ +GLILG I G+ L Y YIKP GD+F+RL+KM++ P++F SLV G S+
Sbjct: 5 QKVTLGLILGIIFGIYLPQY------VNYIKPIGDIFLRLIKMIITPLIFFSLVSGITSM 58
Query: 74 SP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPPLVQ 132
+ + LGRVG+K V +L T+ FA G+ +A + PG GI + + + ++
Sbjct: 59 NDTSALGRVGMKAVAAFLGTTFFATIFGLTIALVLKPGVGIHIDFTSLSTTDRTSFNIID 118
Query: 133 TLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAE 192
+NI+P N A ANG VL +FFAI +GI + +++ + + + I+ +++
Sbjct: 119 FFVNIVPENAVRAFANGNVLQVVFFAIFVGITLN--------KMKSIGKPITDLIHAMSK 170
Query: 193 AMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVLLK 252
+ K+++ V++ +P G FAL ++ QG V+ L+K+ VAV V + Q L V+ +L+
Sbjct: 171 LILKMISFVIKLSPYGAFALTGWIVGMQGFSVMISLSKLVVAVVVAMTCQYL-VFGLLIY 229
Query: 253 VF-GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVA-EDMGISKGIYSFTLPLGATIN 310
+F + PI F K+ + + AF T SS TL TM+V E +GIS+ SF LP+GA+IN
Sbjct: 230 IFCRVSPIPFYKKSFEYQILAFSTSSSKATLATTMQVCREKLGISESSTSFVLPIGASIN 289
Query: 311 MDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESV 370
MDG A+ + T F A +G+ L L I+LT+ L SIG AG+PGA IML MVL SV
Sbjct: 290 MDGFAINLSLTTIFFAQMMGITLAPHDYLVIILTSTLGSIGGAGIPGASLIMLPMVLSSV 349
Query: 371 GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKEGI 423
LP+ A+I GID ILDM RT +N+TGD T T I+ +E L + +
Sbjct: 350 HLPI------EGVAIIAGIDRILDMLRTTINITGDATITMIIDNSEDTLDKKV 396
>pir||B70415 proton/sodium-glutamate symport protein - Aquifex aeolicus
>gi|2983758|gb|AAC07318.1| (AE000735)
proton/sodium-glutamate symport protein [Aquifex
aeolicus]
Length = 398
Score = 265 bits (671), Expect = 6e-70
Identities = 158/413 (38%), Positives = 238/413 (57%), Gaps = 25/413 (6%)
Query: 4 LKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVF 63
+KK L L L+ LIL G+ Y + IK FGD+F+ LLKM+++P+VF
Sbjct: 1 MKKLLSLENLT--LLSLILAVFFGI------YFKEIALNIKLFGDVFLSLLKMIIVPLVF 52
Query: 64 ASLVVGAASI-SPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQF 122
S+ ++ S A+ +G+K +YY T+ AV G+++ I PG G + A +
Sbjct: 53 TSVFTAILNLESLAKFRDLGLKAFLYYFTTTGMAVFTGLVLVNIIQPGKGASGVSAKPEE 112
Query: 123 QPK-QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAE 181
PK Q L +L +IP NPF A + GKVL I FA+ +G+A+ + K E ++
Sbjct: 113 IPKVQEFSLENLILGLIPQNPFEAFSEGKVLQIIVFAVFIGLAVLTIDKFKQEIIK---- 168
Query: 182 TLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLAL 241
N G EA+ ++ V+ P+GVFAL++ ++A G +V+ L + + V +GL +
Sbjct: 169 ---NFFEGFNEALIRLTKWVIVLTPVGVFALVSYLIAKVGYQVLISLWEYALTVLLGLLI 225
Query: 242 QILLVYFVLLKVFG-IDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIY 299
+ ++ +FG +P K+ + ++A+L AF T SS+ TLPV++ +A + G + K +
Sbjct: 226 HAFVNLPLIAYIFGRYNPYKYFIQVREALLLAFSTASSAATLPVSLELAIERGKVKKEVA 285
Query: 300 SFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAG 359
F LPLGATINMDGTALY+ V +IAN G+ L++ Q +TI LTA LASIG A +PGAG
Sbjct: 286 GFVLPLGATINMDGTALYESVAAVYIANLYGIDLSISQMVTIFLTATLASIGAAAIPGAG 345
Query: 360 AIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
++L +VL SVG+PL +I+ +D LDM RT VNV GDL G I+
Sbjct: 346 LVLLTLVLSSVGIPL------EGIGLIIAVDRFLDMLRTAVNVWGDLNGAKIL 392
>pir||G72068 glutamate symport - Chlamydophila pneumoniae (strain CWL029)
>gi|4376817|gb|AAD18668.1| (AE001637) Glutamate Symport
[Chlamydophila pneumoniae CWL029]
>gi|8163390|gb|AAF73644.1| (AE002183)
sodium:dicarboxylate symporter family protein
[Chlamydophila pneumoniae AR39]
>gi|8978899|dbj|BAA98734.1| (AP002547) glutamate symport
[Chlamydophila pneumoniae J138]
Length = 414
Score = 262 bits (663), Expect = 5e-69
Identities = 164/416 (39%), Positives = 238/416 (56%), Gaps = 32/416 (7%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
KI IGL +G +GL+L + + KP GD+F+ LL M+V P+VF S+V+G ASIS
Sbjct: 6 KIFIGLFVGVTLGLVL------EDKAIFFKPIGDIFLNLLSMVVYPLVFCSMVLGIASIS 59
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQP-------KQ 126
+ LGR+G+K V YL T+A A+ +G+ A IF+PG G A+A K
Sbjct: 60 DMKKLGRIGIKSVGLYLGTTALAIVIGLCFAWIFSPGNGCDFAQAQSMDSAVTVIDSNKT 119
Query: 127 APPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNA 186
A + + + P+NP + A G +L I FAI LGIA+ L + V +
Sbjct: 120 AAYFLSIIAQVFPSNPVRSFAEGNILQIIIFAIFLGIALR-LSGERGRPVERF------- 171
Query: 187 INGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLV 246
I+G +E M ++V +M +AP GV A +A + + G+ V+ +L K +A Y+ LV
Sbjct: 172 IDGFSEIMLRMVNMIMSFAPYGVGASMAWISGNHGLGVLWQLGKFIIAYYLACLFHATLV 231
Query: 247 YFVLLKVFG--IDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTL 303
+ L++ FG + KF+S DA+ A T SSS TLPVTMR V++++G+S + F L
Sbjct: 232 FGGLVR-FGCKMSFSKFLSSMMDAISCAVSTASSSATLPVTMRCVSKNLGVSAEVSGFVL 290
Query: 304 PLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIML 363
PLGAT+NM+GTA++QG+ FIA A L+L L +V+TA +++G+AGVPG G I L
Sbjct: 291 PLGATVNMNGTAIFQGMAAVFIAQAYNCPLSLSSLLLLVVTATFSAVGSAGVPGGGMITL 350
Query: 364 AMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
VL SVGLP+ A++ GID + D+ T +N+ GD VA EGEL
Sbjct: 351 GSVLASVGLPI------QGIAILAGIDRLRDIVGTPMNILGDAVVATYVASGEGEL 400
>sp|P21345|GLTP_ECOLI PROTON GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE CARRIER
PROTEIN) >gi|95900|pir||A42384 glutamate-aspartate
carrier protein - Escherichia coli
>gi|147160|gb|AAA24323.1| (M84805) proton-glutamate
[Escherichia coli] >gi|396412|gb|AAC43171.1| (U00006)
gltP [Escherichia coli] >gi|1790514|gb|AAD13460.1|
(AE000481) glutamate-aspartate symport protein
[Escherichia coli K12]
Length = 437
Score = 259 bits (656), Expect = 3e-68
Identities = 147/426 (34%), Positives = 246/426 (57%), Gaps = 30/426 (7%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADA----VKTYIKPFGDLFVRLLKMLVMPI 61
K ++F + +IL ++LG ++G L HY ++D+ V + P GD+F+ L+KM+V+PI
Sbjct: 2 KNIKFSLAWQILFAMVLGILLGSYL-HY-HSDSRDWLVVNLLSPAGDIFIHLIKMIVVPI 59
Query: 62 VFASLVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG- 119
V ++LVVG A + A+ LGR+G K ++Y+ + + A+ LGI +A +F PGAG+ +++
Sbjct: 60 VISTLVVGIAGVGDAKQLGRIGAKTIIYFEVITTVAIILGITLANVFQPGAGVDMSQLAT 119
Query: 120 ---KQFQP------KQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMN 170
++Q + ++ T+L+++PTN ++A G++LP IFF+++ G+ ++ L
Sbjct: 120 VDISKYQSTTEAVQSSSHGIMGTILSLVPTNIVASMAKGEMLPIIFFSVLFGLGLSSLPA 179
Query: 171 SKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAK 230
+ E L+ ++E M+K+ VM+YAP+GVFALIA +A+ G + LAK
Sbjct: 180 TH-------REPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFSSLWPLAK 232
Query: 231 VTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAE 290
+ + V+ + L+V ++ ++ G+ I KD ++ A+ T SS LP + E
Sbjct: 233 LVLLVHFAILFFALVVLGIVARLCGLSVWILIRILKDELILAYSTASSESVLPRIIEKME 292
Query: 291 DMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASI 350
G I SF +P G + N+DG+ LYQ + FIA G+ L++ Q++ +VLT ++ S
Sbjct: 293 AYGAPVSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSK 352
Query: 351 GTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTA 410
G AGVPG ++L L SVG+PL A I G+D ILDM RT +NV G+
Sbjct: 353 GIAGVPGVSFVVLLATLGSVGIPL------EGLAFIAGVDRILDMARTALNVVGNALAVL 406
Query: 411 IVAKTE 416
++AK E
Sbjct: 407 VIAKWE 412
>pir||B75491 proton/sodium-glutamate symport protein - Deinococcus radiodurans
(strain R1) >gi|6458359|gb|AAF10235.1|AE001923_2
(AE001923) proton/sodium-glutamate symport protein
[Deinococcus radiodurans]
Length = 431
Score = 252 bits (637), Expect = 5e-66
Identities = 145/416 (34%), Positives = 231/416 (54%), Gaps = 26/416 (6%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+ILIGL+LG IVG + YG V ++++P GD+F+RL+KM+V+PIV ++L+VG A +
Sbjct: 9 QILIGLVLGVIVGAVF--YGNPTVV-SWLQPLGDIFIRLIKMIVVPIVLSTLIVGVAGVG 65
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ--------FQPK 125
+ LG++G ++Y+ + + A+ G++M +F PGAG+ L + K Q
Sbjct: 66 DMKKLGKLGGLTLIYFEVVTTGAILFGLLMGNLFQPGAGVNLGDLTKTDITKYTEGAQAA 125
Query: 126 QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
+ T +NI+PTN A A G +L IFFA+ G+ + L + + LLN
Sbjct: 126 TSHSFADTFVNIVPTNVVDAFARGDMLAIIFFAVFFGLGLGAL--------GERGKPLLN 177
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILL 245
+A+ M+ + +M+ APIGVFALI ++ GV+ + L K+ + VY + +L+
Sbjct: 178 IFQLVADTMFWVTNQIMKLAPIGVFALIGVTVSKFGVQSLIPLGKLVLVVYGAMLAFVLV 237
Query: 246 VYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPL 305
+ + ++ G I ++ + A+ T SS LP M+ E G + I SF +P
Sbjct: 238 ILGGVARLAGTSIFTLIQVLREELTLAYSTASSESVLPRLMQKMEAFGCPRYITSFVIPT 297
Query: 306 GATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAM 365
G + N+DG+ LYQ + FIA G+H+ L +QL +V+T +L S G AGVPG ++L
Sbjct: 298 GYSFNLDGSTLYQTIAALFIAQLYGIHMPLEKQLLLVVTLMLTSKGIAGVPGVSFVVLLA 357
Query: 366 VLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
L +VG+P+ A I GID ILDM RT VNV G+ ++++ EGE +
Sbjct: 358 TLGTVGIPV------EGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSRFEGEFDD 407
>pir||D71519 probable glutamate symport - Chlamydia trachomatis (serotype D,
strain UW3/Cx) >gi|3328828|gb|AAC67998.1| (AE001313)
Glutamate Symport [Chlamydia trachomatis]
Length = 412
Score = 250 bits (632), Expect = 2e-65
Identities = 153/415 (36%), Positives = 234/415 (55%), Gaps = 35/415 (8%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
KI IGLI+G + GLIL + ++KPFGD+F+ LL M+V P+VF S+V+G ASIS
Sbjct: 6 KIFIGLIIGVVSGLIL------EDKAVFVKPFGDIFLNLLSMVVYPLVFCSMVLGIASIS 59
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG--------ITLAEAGKQFQPK 125
+ LGR+G++ + YL T++ A+ +G+ A F+PG G + LA +G
Sbjct: 60 DMKKLGRIGLRSLGLYLATTSVAIGIGLAFALFFSPGKGCDLQGFNAVDLASSGSS---- 115
Query: 126 QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
+ T + P+NP + G +L I FA+ GIA+ ++A +
Sbjct: 116 GGMNFLATFAQVFPSNPLRSFVEGNILQIIIFALFTGIAMRL--------AGEAARPVER 167
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILL 245
++G E M ++V +M +AP GV A +A + + G+ V+ +L K V Y+ +L
Sbjct: 168 FVHGCNEIMLRMVNMIMSFAPYGVAASMAWISGNHGLTVLLQLGKFLVVYYLACICHAIL 227
Query: 246 VYFVLLKVFGIDPI-KFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTL 303
++ L+++ KF+S DA+ A T SSS TLPVTMR V++++G+S + F L
Sbjct: 228 IFGGLVRLGCRSSFSKFLSSMMDAISCAVSTASSSATLPVTMRCVSKNLGVSSEVSGFVL 287
Query: 304 PLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIML 363
PLGAT+NM+GTA++QG+ FIA A L+L L +V+TA +++G+AGVPG G I L
Sbjct: 288 PLGATVNMNGTAIFQGMAAVFIAQAYNCPLSLTSLLLLVVTATFSAVGSAGVPGGGMITL 347
Query: 364 AMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGE 418
VL SVGLP+ A++ GID + D+ T +N+ GD +A EGE
Sbjct: 348 GSVLTSVGLPI------QGIAVLAGIDRLRDIIGTPMNILGDAVVALYIADGEGE 396
>gb|AAF73590.1| (AE002337) sodium:dicarboxylate symporter family protein [Chlamydia
muridarum]
Length = 409
Score = 249 bits (629), Expect = 5e-65
Identities = 157/411 (38%), Positives = 231/411 (56%), Gaps = 26/411 (6%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
KI IGLI+G + GL+L + ++KPFGD+F+ LL M+V P+VF S+V+G ASIS
Sbjct: 6 KIFIGLIIGVVSGLVL------EDKAVFVKPFGDIFLNLLSMVVYPLVFCSMVLGIASIS 59
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEA-GKQFQPKQAPPL-- 130
+ LGR+G++ + YL T+A A+ +G+ A F PG G L G F Q +
Sbjct: 60 DMKKLGRIGLRSLGLYLGTTAVAIGIGLAFALFFCPGRGCDLQGFNGIDFSAGQPSEINF 119
Query: 131 VQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGL 190
+ + P+NP + G +L I FA+ GIA+ + A + I+G
Sbjct: 120 LTAFAQVFPSNPMRSFVEGNILQIIIFALFTGIALRL--------AGEVARPVEQVIHGC 171
Query: 191 AEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVL 250
E M ++V +M +AP GV A +A + + G+ V+ +L K V Y+ +LV+ L
Sbjct: 172 NEIMLRMVNMIMSFAPYGVAASMAWISGNHGLTVLLQLGKFLVVYYIACICHAVLVFGGL 231
Query: 251 LKVFGIDPIK-FISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGAT 308
+++ F+S DA+ A T SSS TLPVTMR V++++G+S I F LPLGAT
Sbjct: 232 VRLGCRRSFSGFLSSMMDAISCAVSTASSSATLPVTMRCVSKNLGVSSEISGFVLPLGAT 291
Query: 309 INMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLE 368
+NM+GTA++QG+ FIA A L+L L +V+TA +++G+AGVPG G I L VL
Sbjct: 292 VNMNGTAIFQGMAAVFIAQAYNCPLSLTSLLLLVVTATFSAVGSAGVPGGGMITLGSVLA 351
Query: 369 SVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
SVGLP+ A++ GID + D+ T +N+ GD VA EGEL
Sbjct: 352 SVGLPI------QGIAVLAGIDRLRDIIGTPMNILGDSVVALYVANGEGEL 396
>pir||G82777 glutamate symport protein XF0656 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9105534|gb|AAF83466.1|AE003910_2
(AE003910) glutamate symport protein [Xylella
fastidiosa]
Length = 437
Score = 248 bits (626), Expect = 1e-64
Identities = 149/443 (33%), Positives = 234/443 (52%), Gaps = 39/443 (8%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
M + +L P Q+++ G +LGA+VG ++G A KT+ P G L+V L+KM+ +P
Sbjct: 1 MKLISAWLGIPFWQRVVAGFVLGALVGWVMG-----PAAKTWFGPLGTLYVTLIKMIAIP 55
Query: 61 IVFASLVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG 119
+VF +++ A++ R + +G + +++++T+A AV +G+ + + PG G
Sbjct: 56 LVFFAVINAIAALHGQRSVAMLGGRTFLWFIVTAALAVCVGLGVGTLLKPGNGDFTVSVD 115
Query: 120 KQFQPKQAPPLVQTLLNIIPTNPFGALAN-----------------GKVLPTIFFAIVLG 162
+ P + P V LL+++P+NPF AL G +LP IFFA +LG
Sbjct: 116 AAWAPPEVPSPVHVLLDVVPSNPFYALTGIGTRSNSTGETTLAAGRGSILPVIFFAALLG 175
Query: 163 IAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGV 222
+AI L E VRK I ++E M +I V++ P+G F LIA ++ S G
Sbjct: 176 LAIVKLGERVTE-VRK-------LIGQMSEIMIQITRFVLEMTPLGTFGLIATLVGSYGF 227
Query: 223 KVVGELAKVTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTL 282
+ + +A+Y+ A I++VY LL G+ P+KF M AFV+ SS +
Sbjct: 228 QKLLPFGHFVLALYLACAFHIVVVYSGLLLAHGLSPLKFFRGVAPGMQVAFVSSSSFAAM 287
Query: 283 PVTMR-VAEDMGISKGIYSFTLPLGATINMDGT-ALYQGVCTFFIANALGMHLTLGQQLT 340
PV +R + ++G++K +F +PLG++I MDG A++ +C FIA G+ LT Q
Sbjct: 288 PVALRAITHNLGVNKDYAAFAVPLGSSIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFV 347
Query: 341 IVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMV 400
I + +VL S GTAGVPG +M +VL + LPL + ID +LDM RTM
Sbjct: 348 IFIASVLGSFGTAGVPGTAVVMATVVLSAAHLPL------EVIGYLYAIDRVLDMMRTMT 401
Query: 401 NVTGDLTGTAIVAKTEGELKEGI 423
NVTG + +VAK G L +
Sbjct: 402 NVTGQMLVPVLVAKETGLLNTAV 424
>pir||C82232 proton/glutamate symporter VC1168 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9655644|gb|AAF94327.1|
(AE004197) proton/glutamate symporter [Vibrio cholerae]
Length = 458
Score = 238 bits (600), Expect = 1e-61
Identities = 141/406 (34%), Positives = 224/406 (54%), Gaps = 28/406 (6%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+++I ++ G VG +GH DA T P G +F+ L+KMLV+P+V +L+ GAA +
Sbjct: 56 QVVIAMLAGTAVGAAMGH----DA--TLFAPLGAIFINLIKMLVIPLVAVALISGAAGLG 109
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQA-----P 128
+ G+VG + Y+ +TSA AV L +IM +F PG G+ ++ F + A P
Sbjct: 110 DSHSAGKVGAVTLSYFAITSAAAVALALIMGELFQPGVGVDVSGVESMFSSEYAAQGELP 169
Query: 129 PLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAIN 188
T++ +IPTN F +L +L + F + LGIAI+ ++ ++ + ++NA+N
Sbjct: 170 TFWATIIGMIPTNVFQSLNEANILQILVFCLFLGIAIS-------KQAKEKRDPVINAVN 222
Query: 189 GLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYF 248
+ +AM ++ VM APIGVF L+A+ + + G + + K+ V +A+ + Y
Sbjct: 223 TIVDAMVWMINKVMLIAPIGVFGLMADAVGTFGFSALMVVFKLFVVYVAAIAIFGFVAYP 282
Query: 249 VLLKVFG-IDPIKFISKAKDAMLTAFVTRSSSGTLPVTM-RVAEDMGISKGIYSFTLPLG 306
V++++F KFI K A T SS TLPVTM V D+G+ SF LPLG
Sbjct: 283 VMIQLFSKTSAKKFIQAMKKPQAVALSTASSMATLPVTMDTVKNDLGVRNSTASFVLPLG 342
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
ATINM G A+Y G+ F A + L++G + I++TA L ++G AGVPG +++A++
Sbjct: 343 ATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYIAIIVTATLGAVGQAGVPGPSFLVVAVL 402
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
L S G+P+ ++ +D I DM RT +N+TGD IV
Sbjct: 403 L-SAGIPI------EGLPLLFALDRIFDMIRTALNITGDAACAVIV 441
>sp|P39817|GLTP_BACSU PROTON GLUTAMATE SYMPORT PROTEIN (GLUTAMATE-ASPARTATE CARRIER
PROTEIN) >gi|2126946|pir||B57142 H+/glutamate symport
protein gltP - Bacillus subtilis
>gi|558840|gb|AAA82878.1| (U15147) proton/glutamate
symport protein [Bacillus subtilis]
>gi|2632520|emb|CAB12028.1| (Z99105) proton/glutamate
symport protein [Bacillus subtilis]
>gi|3599656|dbj|BAA33131.1| (AB006424) PROTON GLUTAMATE
SYMPORT PROTEIN [Bacillus subtilis]
Length = 414
Score = 231 bits (584), Expect = 9e-60
Identities = 139/425 (32%), Positives = 232/425 (53%), Gaps = 31/425 (7%)
Query: 4 LKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVF 63
+KK + F +ILI L +GA++G +G A ++P GD F+RL+KM+V+PIVF
Sbjct: 1 MKKLIAF----QILIALAVGAVIGHFFPDFGMA------LRPVGDGFIRLIKMIVVPIVF 50
Query: 64 ASLVVGAA-SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQF 122
+++V+GAA S S ++G +G+K ++++ + + + LG+++A + PG G+ L+ K+
Sbjct: 51 STIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLDLSHLAKKD 110
Query: 123 ------QPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERV 176
+ Q +L+IIPTN +A +L IFFAI+ G+A +
Sbjct: 111 IHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA--------GI 162
Query: 177 RKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVY 236
K++E ++ A+ M+K+ VM APIGV AL+A + G++++ + K+ V+
Sbjct: 163 GKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLVGTVF 222
Query: 237 VGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISK 296
+GL L + +++ ++ +F I + + D L AF T S+ LP M E G K
Sbjct: 223 LGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRMEKYGCPK 282
Query: 297 GIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVP 356
+ SF +P G ++N DG++LY V F+A A + +TL QQL ++L V+ S G A VP
Sbjct: 283 RVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMTSKGIAAVP 342
Query: 357 GAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 416
++L +VGLP A A+I G+D ++DM RT VNV G +V+K E
Sbjct: 343 SGSLVVLLATANAVGLP------AEGVAIIAGVDRVMDMARTGVNVPGHAIACIVVSKWE 396
Query: 417 GELKE 421
++
Sbjct: 397 KAFRQ 401
>sp|Q01857|DCTA_RHILE C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|628567|pir||S27384
C4-dicarboxylate transport protein - Rhizobium
leguminosarum >gi|46178|emb|CAA77618.1| (Z11529)
C4-dicarboxylate permease [Rhizobium leguminosarum]
Length = 444
Score = 231 bits (583), Expect = 1e-59
Identities = 136/418 (32%), Positives = 223/418 (52%), Gaps = 25/418 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P + + +++ G++LGH+ Y + + T +KP GD F++L+KM++ P++F ++ G
Sbjct: 17 PFYSHLYVQVLVAIAAGILLGHF-YPE-LGTQLKPLGDAFIKLVKMIIAPVIFLTVATGI 74
Query: 71 ASISPA-RLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ------FQ 123
A +S ++GRV K ++Y+L S A+ +G+I+A + PGAG+ + A F
Sbjct: 75 AGMSDLQKVGRVAGKAMLYFLTFSTLALIIGLIVANVVQPGAGMNIDPASLDPAAVATFA 134
Query: 124 PK-QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
K +V L NIIPT GA A+G +L +FF+++ GIA+ V + E
Sbjct: 135 AKAHEQSIVGFLTNIIPTTIVGAFADGDILQVLFFSVLFGIALAM--------VGEKGEQ 186
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
++N +N L ++K+VA +M+ APIG F +A + GV + LA + Y+ L
Sbjct: 187 VVNFLNSLTAPVFKLVAILMKAAPIGAFGAMAFTIGKYGVGSIANLAMLIGTFYITSLLF 246
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+ +V + + G + + K+ +L T SS LP M E G + +
Sbjct: 247 VFIVLGAVARYNGFSIVALLRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLV 306
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT +Y + FIA A G+HL+ G Q+ ++L A+L+S G AG+ GAG I
Sbjct: 307 IPTGYSFNLDGTNIYMTLAALFIAQATGIHLSWGDQILLLLVAMLSSKGAAGITGAGFIT 366
Query: 363 LAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
LA L V +P+ A A+ILGID + R + N+ G+ T +VA+ E EL
Sbjct: 367 LAATLSVVPSVPV------AGMALILGIDRFMSECRALTNLVGNAVATIVVARWENEL 418
>pir||S71005 glutamate transport protein homolog - Saccharopolyspora erythraea
>gi|1177648|emb|CAA63307.1| (X92556) similar to GltP
glutamate transporters [Saccharopolyspora erythraea]
Length = 449
Score = 227 bits (572), Expect = 2e-58
Identities = 142/418 (33%), Positives = 226/418 (53%), Gaps = 21/418 (5%)
Query: 16 ILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISP 75
++ L+LGA++G I G A + T + G +F LL V+P++F ++VVG S+
Sbjct: 24 VVASLVLGALLGWIAKTTG-ASWLVTVLDTIGSVFTSLLTFTVLPLIFTAIVVGINSLRS 82
Query: 76 ARLGR----VGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQP---KQAP 128
GR +G K +++ TS AV +GI +A +F PG G+ + + K
Sbjct: 83 VGGGRTAARLGGKTALWFAATSLVAVLIGIALAALFQPGRGLVIEPDPAKLSAIGEKTHG 142
Query: 129 PLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAIN 188
+ + ++P N A A G+ L +F A+++G A +Y + K AE +N
Sbjct: 143 SWLDLVNGLVPQNLVSAFAEGETLQVVFVALLIGAA-SYSLGDK-------AEPFVNFNR 194
Query: 189 GLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYF 248
E + +++ +++ APIG LI N +A+ G + L K+ AVYV AL + +VY
Sbjct: 195 SAFEVIQRVLGWIIRLAPIGTLGLIGNAVATYGNEFFTPLLKLIAAVYVACALVLFVVYP 254
Query: 249 VLLK-VFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGA 307
+LL+ V G+ P++F +K + AFV+RSSS TLP++ + AE++G+ + +F +PL
Sbjct: 255 LLLRFVAGVSPVRFFAKTWTVLQFAFVSRSSSATLPLSRQAAENLGVDRSYANFAVPLAT 314
Query: 308 TINMDG-TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
T MDG A+Y + + FIAN G+HL Q LTI+ AV +I TAGV G ML +
Sbjct: 315 TTKMDGCAAIYPAIGSMFIANLFGIHLGPAQYLTIIAVAVFGAIATAGVTG-WFTMLTLT 373
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKEGII 424
+ ++G P VA A+ +D ILDM RT NV G + +VA+TEG L + ++
Sbjct: 374 VGALGFP--PEVVATGIAIAYAVDPILDMMRTATNVAGQIVVPTVVARTEGLLDDEVL 429
>emb|CAB77289.1| (AL160312) putative proton transport protein [Streptomyces
coelicolor A3(2)]
Length = 440
Score = 226 bits (570), Expect = 4e-58
Identities = 143/419 (34%), Positives = 223/419 (53%), Gaps = 24/419 (5%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFAS 65
KYL+ P +IL GL+LG ++G + + V T ++ GD F+ LLK+ V P+VF +
Sbjct: 11 KYLKVPFWAQILAGLVLGVLLGWLARSQDISWLVTT-LEKVGDTFIGLLKLAVAPLVFFA 69
Query: 66 LVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG--ITLAEAGKQF 122
++V ++ R+ + ++++++TS AV +G+++ + NPGAG +T A+ K
Sbjct: 70 ILVSITNLRKVNNAARLASRTLLWFMITSLIAVAIGLVIGLVTNPGAGTGLTAADGAK-- 127
Query: 123 QPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
P+ + L I+PT+ VL +F A V GIA L + A+
Sbjct: 128 -PEHTGSWIDFLTGIVPTDVITPFTELNVLQIVFMAAVAGIAALQL--------GEKAQP 178
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+LN + E + K + V++ AP+G LI +A+ G ++G+ A T +YVG AL
Sbjct: 179 ILNLSESILELLQKALWWVIRLAPLGTVGLIGKAIATYGWDLIGKYATFTADIYVGCALV 238
Query: 243 ILLVYFVLLK-VFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSF 301
+ +VY LL V P++F A A+ AFV+RSS GT+P+T +V E +G+ K SF
Sbjct: 239 MFVVYPTLLATVAKASPLQFFKGAWPAIQLAFVSRSSVGTMPLTQKVTERLGVPKEYASF 298
Query: 302 TLPLGATINMDG-TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
+P GAT MDG A+Y + F+A + L +G L I +V+ S TAG+ GA
Sbjct: 299 AVPFGATTKMDGCAAIYPAIAAIFVAQIFDIQLGVGDYLLIAFVSVVGSAATAGLTGA-T 357
Query: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
+ML + L ++GLP+ ++L ID ILDM RT NV G IV+ EG L
Sbjct: 358 VMLTLTLSTLGLPM------EGVGLLLAIDPILDMMRTATNVAGQALVPVIVSAREGLL 410
>gb|AAF27647.1|AF218211_2 (AF218211) GltP [Vibrio proteolyticus]
Length = 425
Score = 224 bits (566), Expect = 1e-57
Identities = 146/423 (34%), Positives = 219/423 (51%), Gaps = 34/423 (8%)
Query: 15 KILIGLILGAIVGLILGH-YGYADAVKTYI----KPFGDLFVRLLKMLVMPIVFASLVVG 69
KI IGL G ++G + + + TY+ + G +FV L+K+LV+P+V+ S+V G
Sbjct: 8 KIFIGLFAGLLIGTAIQYLFSGVTIFDTYLLGAAEGAGGMFVSLIKLLVVPLVYVSIVCG 67
Query: 70 AASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLA---EAGKQFQPK 125
+ + GR+G K Y++ + A+ + + IF PGA LA +
Sbjct: 68 IVDLKDISAFGRLGGKTFALYIINTIIAIAAALTVGLIFQPGADAHLAGTISESVKLTTT 127
Query: 126 QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
+ P + ++NI+P+NP A ANG +L IF AI+ G+AI L D R + T
Sbjct: 128 ETPDIFSLVVNIVPSNPVQAFANGDMLQIIFMAILTGLAIQAL----DSRGGPAIRTFKM 183
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILL 245
A E M K+V VM AP GVFAL M G + ++VA YV L + +L+
Sbjct: 184 A----NEIMMKLVGLVMSLAPYGVFAL----MIQLGATLNANTYHLSVAGYVALVVAMLV 235
Query: 246 VYFVLLKVF------GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGI 298
+ + G+ P +F+ ++ +L + T SS+ T+PVTMR + E + +SK +
Sbjct: 236 FWIFVFYPMAVGLSTGVTPKQFLRATREQILFSLSTASSNATIPVTMRTLTEKLNVSKSV 295
Query: 299 YSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGA 358
F +PLGAT+NM G ++Y + T F+ANA G + T+ LT +L SIG GVPG
Sbjct: 296 AGFGVPLGATMNMSGVSIYIALATMFVANAFGQPINTADIFTLGLTILLLSIGAGGVPGG 355
Query: 359 GAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGE 418
G M+ ++L +GLP A+I +D I DM T NV GD IVAKTEGE
Sbjct: 356 GVFMVGVLLHQLGLP------PEGLAIIAAVDRINDMFCTSSNVVGDTAVNTIVAKTEGE 409
Query: 419 LKE 421
+ +
Sbjct: 410 ISD 412
>pir||A33597 C4-dicarboxylate transport protein - Rhizobium meliloti
>gi|152163|gb|AAA26252.1| (M26399) C4-dicarboxylate
carrier A (put.); putative [Sinorhizobium meliloti]
>gi|152169|gb|AAA63509.1| (J03683) membrane-associated
dicarboxylate transport protein [Sinorhizobium meliloti]
Length = 453
Score = 224 bits (565), Expect = 2e-57
Identities = 133/420 (31%), Positives = 223/420 (52%), Gaps = 25/420 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P+ + + + ++ G++LGH+ Y D + T +KP GD F+RL+KM++ P++F ++ G
Sbjct: 26 PLYRHLYVQVLAAIAAGILLGHF-YPD-IGTELKPLGDAFIRLVKMIIAPVIFLTVATGI 83
Query: 71 ASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL------AEAGKQFQ 123
A ++ A++GRV K ++Y+L S A+ +G+++A + PGAG+ + A+A +
Sbjct: 84 AGMTDLAKVGRVAGKAMIYFLAFSTLALVVGLVVANVVQPGAGMHIDPASLDAKAVATYA 143
Query: 124 PK-QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
K + L+NIIPT GA A G +L +F +++ GI++ V K AE
Sbjct: 144 EKAHEQSITGFLMNIIPTTLVGAFAEGDILQVLFISVLFGISLAI--------VGKKAEP 195
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+++ + L ++++VA +M+ APIG F +A + G+ + LA + Y+ L
Sbjct: 196 VVDFLQALTLPIFRLVAILMKAAPIGAFGAMAFTIGKYGIASIANLAMLIGTFYLTSFLF 255
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+ +V + + G + I K+ +L T SS LP M E G + +
Sbjct: 256 VFIVLGAVARYNGFSILSLIRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLV 315
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT +Y + FIA A L+ G Q+ ++L A+L+S G AG+ GAG I
Sbjct: 316 IPTGYSFNLDGTNIYMTLAALFIAQATDTPLSYGDQILLLLVAMLSSKGAAGITGAGFIT 375
Query: 363 LAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
LA L V +P+ A A+ILGID + R + N G+ T +VAK EGEL +
Sbjct: 376 LAATLSVVPSVPV------AGMALILGIDRFMSECRALTNFVGNAVATIVVAKWEGELDQ 429
>sp|P20672|DCTA_RHIME C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|152164|gb|AAA26253.1|
(M26399) C4-dicarboxylate carrier A' (put.); putative
[Sinorhizobium meliloti] >gi|152168|gb|AAA63508.1|
(J03683) membrane-associated dicarboxylate transport
protein [Sinorhizobium meliloti]
>gi|455348|gb|AAA26248.1| (M26531) dctA protein
[Sinorhizobium meliloti]
Length = 441
Score = 224 bits (565), Expect = 2e-57
Identities = 133/420 (31%), Positives = 223/420 (52%), Gaps = 25/420 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P+ + + + ++ G++LGH+ Y D + T +KP GD F+RL+KM++ P++F ++ G
Sbjct: 14 PLYRHLYVQVLAAIAAGILLGHF-YPD-IGTELKPLGDAFIRLVKMIIAPVIFLTVATGI 71
Query: 71 ASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL------AEAGKQFQ 123
A ++ A++GRV K ++Y+L S A+ +G+++A + PGAG+ + A+A +
Sbjct: 72 AGMTDLAKVGRVAGKAMIYFLAFSTLALVVGLVVANVVQPGAGMHIDPASLDAKAVATYA 131
Query: 124 PK-QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
K + L+NIIPT GA A G +L +F +++ GI++ V K AE
Sbjct: 132 EKAHEQSITGFLMNIIPTTLVGAFAEGDILQVLFISVLFGISLAI--------VGKKAEP 183
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+++ + L ++++VA +M+ APIG F +A + G+ + LA + Y+ L
Sbjct: 184 VVDFLQALTLPIFRLVAILMKAAPIGAFGAMAFTIGKYGIASIANLAMLIGTFYLTSFLF 243
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+ +V + + G + I K+ +L T SS LP M E G + +
Sbjct: 244 VFIVLGAVARYNGFSILSLIRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLV 303
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT +Y + FIA A L+ G Q+ ++L A+L+S G AG+ GAG I
Sbjct: 304 IPTGYSFNLDGTNIYMTLAALFIAQATDTPLSYGDQILLLLVAMLSSKGAAGITGAGFIT 363
Query: 363 LAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
LA L V +P+ A A+ILGID + R + N G+ T +VAK EGEL +
Sbjct: 364 LAATLSVVPSVPV------AGMALILGIDRFMSECRALTNFVGNAVATIVVAKWEGELDQ 417
>sp|P51907|EAT3_RAT EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY
AMINO-ACID CARRIER 1) >gi|1124986|emb|CAA63937.1|
(X94255) glutamate transporter REAAC1 [Rattus
norvegicus]
Length = 523
Score = 224 bits (565), Expect = 2e-57
Identities = 152/461 (32%), Positives = 234/461 (49%), Gaps = 75/461 (16%)
Query: 12 VLQKILIGLILGAIVG-LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
+L + ++LG +VG L+ GH ++ K Y G++ +R+LK++++P++ +S++ G
Sbjct: 20 LLLSTVAAVVLGIVVGVLVRGHSELSNLDKFYFAFPGEILMRMLKLVILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ VVYY T+ AV LGI++ PG + E GK +
Sbjct: 80 AALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEY 199
Query: 144 ---GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVA 199
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 KIVGLYSDGINVLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIVQ 251
Query: 200 GVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKVF 254
+M Y PIG+ LIA ++ + ++ +L V GLA+ L L+YF++++
Sbjct: 252 IIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRK- 310
Query: 255 GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDG 313
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMDG
Sbjct: 311 --NPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPVGATINMDG 368
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ V FIA GM L++GQ +TI +TA ASIG AGVP AG + + +VL +VGLP
Sbjct: 369 TALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSAVGLP 428
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 AEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 463
>pir||C69771 C4-dicarboxylate transport protein homolog ydbH - Bacillus subtilis
>gi|1881257|dbj|BAA19284.1| (AB001488) PROBABLE
C4-DICARBOXYLATE TRANSPORT PROTEIN. [Bacillus subtilis]
>gi|2632747|emb|CAB12254.1| (Z99106) similar to
C4-dicarboxylate transport protein [Bacillus subtilis]
Length = 421
Score = 224 bits (565), Expect = 2e-57
Identities = 126/415 (30%), Positives = 227/415 (54%), Gaps = 28/415 (6%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+++ +I+G IVGL+ G +KP GD F+ +KM++ PI+F ++V+G A +
Sbjct: 10 QVITAVIIGVIVGLVWPDVGKE------MKPLGDTFINAVKMVIAPIIFFTIVLGIAKMG 63
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK----QFQPK--QA 127
+ +G+VG K +Y+ + + A+ +G+ + I PGAG+ ++ K Q+ Q
Sbjct: 64 DMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAGLDYSKLEKGDVSQYTQNGGQG 123
Query: 128 PPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAI 187
++ + +I+P+N A A G +L +FF+I+ G+ + L + +++++
Sbjct: 124 IDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVGLAAL--------GEKGKSVIDFF 175
Query: 188 NGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVY 247
+ ++ +KI+ +M+ APIG F +A + G+ + LA + ++VY+ + L + +
Sbjct: 176 DKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLASLMMSVYITMFLFVFVAL 235
Query: 248 FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGA 307
++ K++G ++ KD +L T SS LP M E G SK + +P G
Sbjct: 236 NIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDKMERYGCSKSVVGLVIPTGY 295
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
+ N+DGT++Y + T F+A G+ L++GQQ+TI+L +L S G AGV G+G I+LA L
Sbjct: 296 SFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLMLTSKGAAGVTGSGFIVLASTL 355
Query: 368 ESVG-LPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
++ +PL A++LG+D + GR +VN+ G+ T IVAK+E E E
Sbjct: 356 SALQVIPL------EGLALLLGVDRFMSEGRAIVNLIGNGIATIIVAKSENEFDE 404
>dbj|BAA09849.1| (D63772) neuronal high affinity glutamate transporter [Rattus
norvegicus]
Length = 523
Score = 224 bits (564), Expect = 2e-57
Identities = 153/461 (33%), Positives = 233/461 (50%), Gaps = 75/461 (16%)
Query: 12 VLQKILIGLILGAIVG-LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
+L + ++LG +VG L+ GH ++ K Y G++ +R+LK+++MP++ +S++ G
Sbjct: 20 LLLSTVAAVVLGIVVGVLVRGHSELSNLDKFYFAFPGEILMRMLKLVIMPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G+ VVYY T+ AV LGI++ PG + E GK +
Sbjct: 80 AALDSNVSGKIGLCAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEY 199
Query: 144 ---GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVA 199
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 KIVGLYSDGINVLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIVQ 251
Query: 200 GVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKVF 254
+M Y PIG+ LIA ++ + ++ +L V GLA+ L L+YF++++
Sbjct: 252 IIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRK- 310
Query: 255 GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDG 313
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMDG
Sbjct: 311 --NPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPVGATINMDG 368
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ V FIA GM L++GQ +TI +TA ASIG AGVP AG + + +VL +VGLP
Sbjct: 369 TALYEAVAAVFIAQVNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSAVGLP 428
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 AEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 463
>pir||F82619 proton glutamate symport protein XF1937 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107035|gb|AAF84739.1|AE004013_5 (AE004013) proton
glutamate symport protein [Xylella fastidiosa]
Length = 447
Score = 224 bits (564), Expect = 2e-57
Identities = 139/433 (32%), Positives = 231/433 (53%), Gaps = 33/433 (7%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTY------IKPFGDLFVRLLKMLVMPIVFA 64
P+ K+ IG + G ++GL ++ AD V PF LF+ L+ ML++P++F+
Sbjct: 28 PMHWKMSIGFLGGLLIGLAAHYWVGADVVWVQHATHYLTTPFSKLFLNLIFMLIVPLMFS 87
Query: 65 SLVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL-------- 115
+LVVG A + R LGR+G + + Y ++ S+ AV +G+++ + PG G+
Sbjct: 88 ALVVGVAEMGDIRALGRIGWRTLGYTVVLSSVAVLVGLVLVNVLKPGVGVDPQLAQQLLS 147
Query: 116 --AEAGKQFQPKQAPPL--VQTLLNIIPTNPFGALA-NGKVLPTIFFAIVLGIAITYLMN 170
AE +Q + + LL+I+P+N A + N +L +FF I+ GI + +
Sbjct: 148 ENAERSRQIVASTDTQIHGMDMLLSIVPSNVVAAASSNDAILSLMFFTIMFGIGMVLVPQ 207
Query: 171 SKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAK 230
K ETL AI G+ E ++ V++ AP V + N+ + G++++ LA
Sbjct: 208 EK-------VETLKRAIEGVFEVSMVLIGLVIRLAPYAVACFMFNLTSLFGLELLIRLAA 260
Query: 231 VTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAE 290
V +GL+L + + Y + + G P++F + ++A L AF T SS+ TLP +RVA+
Sbjct: 261 YVGVVVLGLSLHMFVTYGLAVWWAGRSPLRFFRETQEATLMAFSTASSNATLPTALRVAD 320
Query: 291 DMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASI 350
+M + K I F L +GAT N +GTAL++G+ F+A G+ L+ QQ ++ +L I
Sbjct: 321 EMKLPKQISRFVLTIGATANQNGTALFEGLTVIFLAQFFGVDLSFSQQAMVMAVCILGGI 380
Query: 351 GTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTA 410
GTAGVP ++A++ VG+ +ILG++ LDM RT +NVTGDL T
Sbjct: 381 GTAGVPSGSLPVVALICAMVGID------PVGIGLILGVNHFLDMCRTALNVTGDLALTT 434
Query: 411 IVAKTEGELKEGI 423
+V + E + K +
Sbjct: 435 LVCRGEPQPKGSV 447
>gb|AAF34319.1|U21104_1 (U21104) neuronal glutamate transporter [Rattus norvegicus]
Length = 523
Score = 223 bits (563), Expect = 3e-57
Identities = 152/461 (32%), Positives = 233/461 (49%), Gaps = 75/461 (16%)
Query: 12 VLQKILIGLILGAIVG-LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
+L + ++LG +VG L+ GH ++ K Y G++ +R+LK++++P++ +S++ G
Sbjct: 20 LLLSTVAAVVLGIVVGVLVRGHSELSNLDKFYFAFPGEILMRMLKLVILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ VVYY T+ AV LGI++ PG + E GK +
Sbjct: 80 AALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEY 199
Query: 144 ---GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVA 199
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 KIVGLYSDGINVLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIVQ 251
Query: 200 GVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKVF 254
+M Y PIG+ LIA ++ + ++ +L V GLA+ L L+YF++++
Sbjct: 252 IIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRK- 310
Query: 255 GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDG 313
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMDG
Sbjct: 311 --NPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPVGATINMDG 368
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ V FIA GM L++GQ +TI +TA ASIG AGVP AG + + +VL VGLP
Sbjct: 369 TALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSPVGLP 428
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 AEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 463
>gb|AAB09773.1| (U39555) EAAC1 [Rattus norvegicus]
Length = 523
Score = 222 bits (561), Expect = 4e-57
Identities = 152/461 (32%), Positives = 234/461 (49%), Gaps = 75/461 (16%)
Query: 12 VLQKILIGLILGAIVG-LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
+L + ++LG +VG L+ GH ++ K Y G++ +R+LK++++P++ +S++ G
Sbjct: 20 LLLSTVAAVVLGIVVGVLVRGHSELSNLDKFYFAFPGEILMRMLKLVILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ VVYY T+ AV LGI++ PG + E GK +
Sbjct: 80 AALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + NI+ N
Sbjct: 140 DAMLDLIRNILGENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEY 199
Query: 144 ---GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVA 199
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 KIVGLYSDGINVLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIVQ 251
Query: 200 GVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKVF 254
+M Y PIG+ LIA ++ + ++ +L V GLA+ L L+YF++++
Sbjct: 252 IIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRK- 310
Query: 255 GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDG 313
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMDG
Sbjct: 311 --NPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPVGATINMDG 368
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ V FIA GM L++GQ +TI +TA ASIG AGVP AG + + +VL +VGLP
Sbjct: 369 TALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSAVGLP 428
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 AEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 463
>emb|CAA70413.1| (Y09212) proton /sodium-glutamate symport protein [Bacillus cereus]
Length = 355
Score = 221 bits (557), Expect = 1e-56
Identities = 118/350 (33%), Positives = 200/350 (56%), Gaps = 22/350 (6%)
Query: 77 RLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL-----AEAGKQFQPKQAPP-- 129
+LG++G K ++Y+ + + A+ +G++ A IF PG G+ + ++ Q A
Sbjct: 1 KLGKLGGKTILYFEIITTIAILMGLLAANIFQPGTGVDMNNLQQSDISSYKQTADATEKQ 60
Query: 130 -LVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAIN 188
+T+++I+P N F ++A G +LP IFF+++ G+ + + + + + N
Sbjct: 61 GFAETIVHIVPKNVFESIAQGDLLPIIFFSVLFGLGVA--------AIGEKGKPVFNFFE 112
Query: 189 GLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYF 248
G+ EAM+ + VM++AP GVFALIA +A GV + L K+ +AVYV + L +++V
Sbjct: 113 GVLEAMFWVTNQVMKFAPFGVFALIAVTVAKFGVATLLPLGKLVLAVYVTVILFVVIVLG 172
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGAT 308
+ ++ G++ + K+ ++ +F T SS LP MR E+ G K + SF +P G T
Sbjct: 173 INARMVGVNIFTLMKILKEELILSFTTASSEAVLPNIMRKMEEFGCPKAVASFVIPTGYT 232
Query: 309 INMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLE 368
N+ G+A+YQ + F+A G+H++L +Q+T++ +L S G AGVPGA +++ L
Sbjct: 233 FNLTGSAIYQALAALFVAQMYGVHMSLTEQITLLFVLMLTSKGMAGVPGASFVVVLATLG 292
Query: 369 SVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGE 418
S+GLPL A+I GID ILDM R+ VNV G+ +++K EGE
Sbjct: 293 SMGLPL------EGIALIAGIDRILDMIRSSVNVLGNALAAIVMSKWEGE 336
>sp|P51906|EAT3_MOUSE EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY
AMINO-ACID CARRIER 1) >gi|1363137|pir||S55677 glutamate
transporter MEAAC1 - mouse >gi|984640|dbj|BAA07855.1|
(D43797) glutamate transporter MEAAC1 [Mus musculus]
>gi|1098051|prf||2115216B Glu transporter:ISOTYPE=MEAAC1
[Mus musculus]
Length = 523
Score = 220 bits (554), Expect = 3e-56
Identities = 150/465 (32%), Positives = 236/465 (50%), Gaps = 77/465 (16%)
Query: 7 YLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASL 66
+L + +++G++LG +V GH ++ K Y G++ +R+LK++++P++ +S+
Sbjct: 19 WLLLSTVAAVVLGIVLGVVVR---GHSELSNLDKFYFAFPGEILMRMLKLVILPLIVSSM 75
Query: 67 VVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQ 123
+ G A++ G++G++ VVYY T+ AV LGI++ PG + + GK +
Sbjct: 76 ITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNDINRTGKTPE 135
Query: 124 PKQAPPLVQTLLNIIPTN-----------------PFG----------------ALANGK 150
++ + N+ P N P G ++ K
Sbjct: 136 VSTIDAMLDLIRNMFPENLVQACFQQYKTKREEVKPVGDPGGNATEVSVTTAMTTMSENK 195
Query: 151 ---------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
VL I F +V G+ I ++ + + L++ N L++A
Sbjct: 196 TKEYKIVGLYSDGINVLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATM 247
Query: 196 KIVAGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQILLV----YFVL 250
KIV +M Y PIG+ LIA ++ + ++ +L V GLA+ L+V YF++
Sbjct: 248 KIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLIVLPLLYFIV 307
Query: 251 LKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATI 309
++ +P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATI
Sbjct: 308 VRK---NPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATI 364
Query: 310 NMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLES 369
NMDGTALY+ V FIA G+ L++GQ +TI +TA ASIG AGVP AG + + +VL +
Sbjct: 365 NMDGTALYEAVAAVFIAQLNGLDLSIGQIVTISITATAASIGAAGVPQAGLVTMVIVLSA 424
Query: 370 VGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
VGLP D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 425 VGLPAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 463
>sp|P50334|DCTA_SALTY C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|993024|emb|CAA62742.1|
(X91397) DctA [Salmonella typhimurium]
Length = 428
Score = 220 bits (554), Expect = 3e-56
Identities = 128/417 (30%), Positives = 224/417 (53%), Gaps = 26/417 (6%)
Query: 13 LQKILIGLILGAI-VGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
L K L +L AI +G++LGHY Y + + +KP GD FV+L+KM++ P++F ++V G A
Sbjct: 5 LFKSLYFQVLTAIAIGILLGHY-YPE-LGAQMKPLGDAFVKLIKMIIAPVIFCTVVTGIA 62
Query: 72 SISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQP------ 124
+ + +GR G ++Y+ + S A+ +G+I+ + PGAG+ + A Q
Sbjct: 63 GMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAQAVAVYAA 122
Query: 125 -KQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETL 183
+ ++ L+++IP + GA A+G +L + FA++ G A+ R+ + +
Sbjct: 123 QAKEQGIIAFLMDVIPGSVIGAFASGNILQVLLFAVLFGFAL--------HRLGSKGQLI 174
Query: 184 LNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQI 243
N I ++ ++ I+ +M+ APIG F +A + GV + +L ++ + Y+ L +
Sbjct: 175 FNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGSLVQLGQLIICFYITCILFV 234
Query: 244 LLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTL 303
++V + +V G KFI ++ +L T SS LP + E +G K + +
Sbjct: 235 VVVLGTIARVTGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVI 294
Query: 304 PLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIML 363
P G + N+DGT++Y + FIA A H+ + Q+T+++ +L+S G AGV G+G I+L
Sbjct: 295 PTGYSFNLDGTSIYLTMAAVFIAQATNSHMDIFHQITLLVVLLLSSKGAAGVTGSGFIVL 354
Query: 364 AMVLESVG-LPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
A + +VG LP+ A A+ILGID + R + N+ G+ T +VAK EL
Sbjct: 355 AATISAVGHLPV------AGLALILGIDRFMSEARALTNLVGNGVATVVVAKWVKEL 405
>gi|6678001 solute carrier family 1, member 1 [Mus musculus]
>gi|2459552|gb|AAB80694.1| (U73521) glutamate
transporter [Mus musculus]
Length = 523
Score = 220 bits (554), Expect = 3e-56
Identities = 150/465 (32%), Positives = 236/465 (50%), Gaps = 77/465 (16%)
Query: 7 YLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASL 66
+L + +++G++LG +V GH ++ K Y G++ +R+LK++++P++ +S+
Sbjct: 19 WLLLSTVAAVVLGIVLGVVVR---GHSELSNLDKFYFAFPGEILMRMLKLVILPLIVSSM 75
Query: 67 VVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQ 123
+ G A++ G++G++ VVYY T+ AV LGI++ PG + + GK +
Sbjct: 76 ITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNDINRTGKTPE 135
Query: 124 PKQAPPLVQTLLNIIPTN-----------------PFG----------------ALANGK 150
++ + N+ P N P G ++ K
Sbjct: 136 VSTMDAMLDLIRNMFPENLVQACFQQYKTKREEVKPVGDPGGNATEVSVTTAMTTMSENK 195
Query: 151 ---------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
VL I F +V G+ I ++ + + L++ N L++A
Sbjct: 196 TKEYKIVGLYSDGINVLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATM 247
Query: 196 KIVAGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQILLV----YFVL 250
KIV +M Y PIG+ LIA ++ + ++ +L V GLA+ L+V YF++
Sbjct: 248 KIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLIVLPLLYFIV 307
Query: 251 LKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATI 309
++ +P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATI
Sbjct: 308 VRK---NPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATI 364
Query: 310 NMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLES 369
NMDGTALY+ V FIA G+ L++GQ +TI +TA ASIG AGVP AG + + +VL +
Sbjct: 365 NMDGTALYEAVAAVFIAQLNGLDLSIGQIVTISITATAASIGAAGVPQAGLVTMVIVLSA 424
Query: 370 VGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
VGLP D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 425 VGLPAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 463
>sp|P31601|DCTA_RHISN C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|1486443|emb|CAA92421.1|
(Z68203) C4-dicarboxylate transporter [Rhizobium sp.]
>gi|2182674|gb|AAB91894.1| (AE000101) DctA1 [Rhizobium
sp. NGR234]
Length = 504
Score = 218 bits (550), Expect = 9e-56
Identities = 133/418 (31%), Positives = 224/418 (52%), Gaps = 25/418 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P + + + ++ VG++LG++ Y D V + +KP GD F+ L+KM++ P++F ++ G
Sbjct: 29 PHYRHLYVQVLAAIAVGILLGYF-YPD-VGSKMKPLGDAFIMLVKMIIAPVIFLTVATGI 86
Query: 71 ASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL------AEAGKQFQ 123
A ++ A++GRV K ++Y+L S A+ +G+++A + PGAG+ + A+A +
Sbjct: 87 AGMTDLAKVGRVAGKAMIYFLTFSTLALLVGLVVANVVQPGAGMHIDPASLDAKAIATYA 146
Query: 124 PKQAPPLVQT-LLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
K V L+NIIPT GA A G +L +F +++ GI++ V K AE
Sbjct: 147 EKAHEQSVTGFLMNIIPTTLVGAFAEGDILQVLFISVLFGISLAI--------VGKKAEA 198
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+++ ++ L ++++VA +M+ APIG F +A + GV + LA + Y+ L
Sbjct: 199 VVDFLHALTLPIFRLVAILMKAAPIGAFGAMAFTIGKYGVASIANLAMLIGTFYLTSFLF 258
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+ +V + + G + I K+ +L T SS LP M E G + +
Sbjct: 259 VFMVLGAVARYNGFSIVALIRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLV 318
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT +Y + FIA A ++ G Q+ ++L A+L+S G AG+ GAG I
Sbjct: 319 IPTGYSFNLDGTNIYMTLAALFIAQATDTPISYGDQILLLLIAMLSSKGAAGITGAGFIT 378
Query: 363 LAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
LA L +V +P+ A A+ILGID + R + N+ G+ T +VAK EGEL
Sbjct: 379 LAATLSAVPSVPV------AGMALILGIDRFMSECRAITNIIGNAVATIVVAKWEGEL 430
>gb|AAF14541.2|AF167075_1 (AF167075) glutamate transporter [Canis familiaris]
Length = 524
Score = 218 bits (549), Expect = 1e-55
Identities = 143/462 (30%), Positives = 233/462 (49%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
+L + ++LG +G+++ Y +++ + F G++ +R+LK++++P++ +S++ G
Sbjct: 20 LLLSTVAAVVLGIAIGVLVREYSKLSSLEKFYFAFPGEILMRMLKLIILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ + G++G++ V+YY T+ AV LGI++ PG + E G +
Sbjct: 80 AALDSSVSGKIGLRAVIYYFCTTVIAVVLGIVLVVSIKPGVSQKVDEIDRTGSSPEVSTV 139
Query: 128 PPLVQTLLNIIPTN---------------------------------------------- 141
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVSSPSEPGMNMTEASVTAIMTTAISKNKTKE 199
Query: 142 --PFGALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 YKVVGMYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQVLVDFFNALSDATMKIV 251
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y P+G+ LIA ++ + ++ +L V GLA+ + L+YF++++
Sbjct: 252 QIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSIIILPLIYFIVVRK 311
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 312 ---NPFRFAMGMAQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATINMD 368
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA G+ L +GQ +TI +TA ASIG AGVP AG + + +VL +VGL
Sbjct: 369 GTALYEAVAAVFIAQLDGLDLGIGQIITISVTATAASIGAAGVPQAGLVTMVIVLSAVGL 428
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 PPEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 464
>gb|AAB22401.1| (S38912) NGRDCTA2=47 kda C4-dicarboxylate transport protein
[Rhizobium leguminosarum, NGR234, symbiotic megaplasmid
pSym, Peptide Plasmid, 449 aa]
Length = 449
Score = 217 bits (546), Expect = 3e-55
Identities = 132/418 (31%), Positives = 223/418 (52%), Gaps = 25/418 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P + + + ++ VG++LG++ Y D V + +KP GD F+ L+KM++ P++F ++ G
Sbjct: 22 PHYRHLYVQVLAAIAVGILLGYF-YPD-VGSKMKPLGDAFIMLVKMIIAPVIFLTVATGI 79
Query: 71 ASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL------AEAGKQFQ 123
A ++ A++GRV K ++Y+L S A+ +G+++A + PGAG+ + A+A +
Sbjct: 80 AGMTDLAKVGRVAGKAMIYFLAFSTLALLVGLVVANVVQPGAGMHIDPASLDAKAIATYA 139
Query: 124 PKQAPPLVQT-LLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
K V L+NIIPT GA A G +L +F +++ GI++ V K AE
Sbjct: 140 EKAHEQSVTGFLMNIIPTTLVGAFAEGDILQVLFISVLFGISLAI--------VGKKAEA 191
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+++ ++ L ++++VA +M+ APIG F +A + GV + LA + Y+ L
Sbjct: 192 VVDFLHALTLPIFRLVAILMKAAPIGAFGAMAFTIGKYGVASIANLAMLIGTFYLTSFLF 251
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+ +V + + G + I K+ +L T SS LP M E G + +
Sbjct: 252 VFMVLGAVARYNGFSIVALIRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLV 311
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT +Y + FIA ++ G Q+ ++L A+L+S G AG+ GAG I
Sbjct: 312 IPTGYSFNLDGTNIYMTLAALFIAQGTDTPISYGDQILLLLIAMLSSKGAAGITGAGFIT 371
Query: 363 LAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
LA L +V +P+ A A+ILGID + R + N+ G+ T +VAK EGEL
Sbjct: 372 LAATLSAVPSVPV------AGMALILGIDRFMSECRAITNIIGNAVATIVVAKWEGEL 423
>gb|AAB22400.1| (S38912) NGRDCTA1=47.8 kda C4-dicarboxylate transport protein
[Rhizobium leguminosarum, NGR234, symbiotic megaplasmid
pSym, Peptide Plasmid, 456 aa]
Length = 456
Score = 217 bits (546), Expect = 3e-55
Identities = 132/418 (31%), Positives = 223/418 (52%), Gaps = 25/418 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P + + + ++ VG++LG++ Y D V + +KP GD F+ L+KM++ P++F ++ G
Sbjct: 29 PHYRHLYVQVLAAIAVGILLGYF-YPD-VGSKMKPLGDAFIMLVKMIIAPVIFLTVATGI 86
Query: 71 ASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL------AEAGKQFQ 123
A ++ A++GRV K ++Y+L S A+ +G+++A + PGAG+ + A+A +
Sbjct: 87 AGMTDLAKVGRVAGKAMIYFLAFSTLALLVGLVVANVVQPGAGMHIDPASLDAKAIATYA 146
Query: 124 PKQAPPLVQT-LLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
K V L+NIIPT GA A G +L +F +++ GI++ V K AE
Sbjct: 147 EKAHEQSVTGFLMNIIPTTLVGAFAEGDILQVLFISVLFGISLAI--------VGKKAEA 198
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+++ ++ L ++++VA +M+ APIG F +A + GV + LA + Y+ L
Sbjct: 199 VVDFLHALTLPIFRLVAILMKAAPIGAFGAMAFTIGKYGVASIANLAMLIGTFYLTSFLF 258
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+ +V + + G + I K+ +L T SS LP M E G + +
Sbjct: 259 VFMVLGAVARYNGFSIVALIRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLV 318
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT +Y + FIA ++ G Q+ ++L A+L+S G AG+ GAG I
Sbjct: 319 IPTGYSFNLDGTNIYMTLAALFIAQGTDTPISYGDQILLLLIAMLSSKGAAGITGAGFIT 378
Query: 363 LAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
LA L +V +P+ A A+ILGID + R + N+ G+ T +VAK EGEL
Sbjct: 379 LAATLSAVPSVPV------AGMALILGIDRFMSECRAITNIIGNAVATIVVAKWEGEL 430
>sp|P24942|EAT1_RAT EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 1) (GLAST)
>gi|285094|pir||S26609 glutamate/aspartate transport
protein - rat >gi|56269|emb|CAA45276.1| (X63744)
glutamate/aspartate transporter [Rattus norvegicus]
Length = 543
Score = 216 bits (545), Expect = 3e-55
Identities = 152/447 (34%), Positives = 225/447 (50%), Gaps = 64/447 (14%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI--TLAEAGKQFQPKQAPPLVQTLLNI 137
++G++ VVYY+ T+ AV +GII+ I +PG G + GK Q A + + N+
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNM 177
Query: 138 IPTNPFGALANG--------------KVLPTIFFAIVLGI--AITYLMNSKDERV----- 176
P N A + T+ A++ + A+ L ++E V
Sbjct: 178 FPPNLVEACFKQFKTSYEKRSFKVPIQANETLLGAVINNVSEAMETLTRIREEMVPVPGS 237
Query: 177 -----------------------RKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALI 213
++ + L + L EA+ ++VA +M YAP+G+ LI
Sbjct: 238 VNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLI 297
Query: 214 ANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVFGIDPIKFISKAK 266
A M GV + G+LA TV V VGL + ++V YF++ + +P FI
Sbjct: 298 AGKILEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK---NPWVFIGGLL 353
Query: 267 DAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFI 325
A++TA T SSS TLP+T + + E+ G+ K I F LP+GATINMDGTALY+ + FI
Sbjct: 354 QALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFI 413
Query: 326 ANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAM 385
A L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP D +
Sbjct: 414 AQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ITL 467
Query: 386 ILGIDAILDMGRTMVNVTGDLTGTAIV 412
I+ +D LD RT NV GD G IV
Sbjct: 468 IIAVDWFLDRLRTTTNVLGDSLGAGIV 494
>gi|9507115 solute carrier family 1, member 3 [Rattus sp.]
>gi|2144072|pir||I58189 glutamate transporter - rat
>gi|299942|gb|AAB26422.1| (S59158) glutamate
transporter, GluT-1 [rats, forebrain, Peptide, 543 aa]
[Rattus sp.]
Length = 543
Score = 216 bits (545), Expect = 3e-55
Identities = 152/447 (34%), Positives = 225/447 (50%), Gaps = 64/447 (14%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI--TLAEAGKQFQPKQAPPLVQTLLNI 137
++G++ VVYY+ T+ AV +GII+ I +PG G + GK Q A + + N+
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNM 177
Query: 138 IPTNPFGALANG--------------KVLPTIFFAIVLGI--AITYLMNSKDERV----- 176
P N A + T+ A++ + A+ L ++E V
Sbjct: 178 FPPNLVEACFKQFKTSYEKRSFKVPIQANETLLGAVINNVSEAMETLTRIREEMVPVPGS 237
Query: 177 -----------------------RKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALI 213
++ + L + L EA+ ++VA +M YAP+G+ LI
Sbjct: 238 VNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLI 297
Query: 214 ANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVFGIDPIKFISKAK 266
A M GV + G+LA TV V VGL + ++V YF++ + +P FI
Sbjct: 298 AGKIVEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK---NPWVFIGGLL 353
Query: 267 DAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFI 325
A++TA T SSS TLP+T + + E+ G+ K I F LP+GATINMDGTALY+ + FI
Sbjct: 354 QALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFI 413
Query: 326 ANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAM 385
A L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP D +
Sbjct: 414 AQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ITL 467
Query: 386 ILGIDAILDMGRTMVNVTGDLTGTAIV 412
I+ +D LD RT NV GD G IV
Sbjct: 468 IIAVDWFLDRLRTTTNVLGDSLGAGIV 494
>prf||1922355A Glu transporter [Mus musculus]
Length = 543
Score = 216 bits (545), Expect = 3e-55
Identities = 153/447 (34%), Positives = 224/447 (49%), Gaps = 64/447 (14%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI--TLAEAGKQFQPKQAPPLVQTLLNI 137
++G++ VVYY+ T+ AV +GII+ I +PG G + GK Q A + + N+
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNM 177
Query: 138 IPTNPFGAL---------ANGKVLPTIFFAIVLGIAITYLMNSKDE--RVRKSAETLLNA 186
P N A +P +LG I + + + R+R+ + +
Sbjct: 178 FPPNLVEACFKQFKTSYEKRSFKVPIQSNETLLGAVINNVSEAMETLTRIREEMVPVPGS 237
Query: 187 ING---------------------------------LAEAMYKIVAGVMQYAPIGVFALI 213
+NG L EA+ ++VA +M YAP+G+ LI
Sbjct: 238 VNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLI 297
Query: 214 ANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVFGIDPIKFISKAK 266
A M GV + G+LA TV V VGL + ++V YF++ + +P FI
Sbjct: 298 AGKIVEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK---NPWVFIGGLL 353
Query: 267 DAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFI 325
A++TA T SSS TLP+T + + E+ G+ K I F LP+GATINMDGTALY+ + FI
Sbjct: 354 QALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFI 413
Query: 326 ANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAM 385
A L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP D +
Sbjct: 414 AQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ITL 467
Query: 386 ILGIDAILDMGRTMVNVTGDLTGTAIV 412
I+ +D LD RT NV GD G IV
Sbjct: 468 IIAVDWFLDRLRTTTNVLGDSLGAGIV 494
>sp|P56564|EAT1_MOUSE EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER) (HIGH-AFFINITY NEURONAL
GLUTAMATE TRANSPORTER) (GLIAL HIGH AFFINITY GLUTAMATE
TRANSPORTER) (GLAST)
Length = 543
Score = 216 bits (545), Expect = 3e-55
Identities = 153/447 (34%), Positives = 224/447 (49%), Gaps = 64/447 (14%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI--TLAEAGKQFQPKQAPPLVQTLLNI 137
++G++ VVYY+ T+ AV +GII+ I +PG G + GK Q A + + N+
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNM 177
Query: 138 IPTNPFGAL---------ANGKVLPTIFFAIVLGIAITYLMNSKDE--RVRKSAETLLNA 186
P N A +P +LG I + + + R+R+ + +
Sbjct: 178 FPPNLVEACFKQFKTSYEKRSFKVPIQSNETLLGAVINNVSEAMETLTRIREEMVPVPGS 237
Query: 187 ING---------------------------------LAEAMYKIVAGVMQYAPIGVFALI 213
+NG L EA+ ++VA +M YAP+G+ LI
Sbjct: 238 VNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLI 297
Query: 214 ANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVFGIDPIKFISKAK 266
A M GV + G+LA TV V VGL + ++V YF++ + +P FI
Sbjct: 298 AGKILEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK---NPWVFIGGLL 353
Query: 267 DAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFI 325
A++TA T SSS TLP+T + + E+ G+ K I F LP+GATINMDGTALY+ + FI
Sbjct: 354 QALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFI 413
Query: 326 ANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAM 385
A L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP D +
Sbjct: 414 AQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ITL 467
Query: 386 ILGIDAILDMGRTMVNVTGDLTGTAIV 412
I+ +D LD RT NV GD G IV
Sbjct: 468 IIAVDWFLDRLRTTTNVLGDSLGAGIV 494
>sp|Q95135|EAT3_BOVIN EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY
AMINO-ACID CARRIER 1) (RENAL HIGH AFFINITY GLUTAMATE
TRANSPORTER EAAC1) >gi|1613882|gb|AAB16815.1| (U72534)
renal high affinity glutamate transporter BEAAC1 [Bos
taurus]
Length = 524
Score = 216 bits (544), Expect = 4e-55
Identities = 146/462 (31%), Positives = 232/462 (49%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
+L ++ ++LG ++G+++ Y ++ + F G++ +R+LK++++P++ +S++ G
Sbjct: 20 LLLSTVVAVVLGIVIGVLVREYSKLSNLEKFYFSFPGEILMRMLKLVILPLIVSSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ VVYY T+ AV LGI++ PG + E G +
Sbjct: 80 ATLDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVNEIDRTGNTPEVSTV 139
Query: 128 PPLVQTLLNIIPTN---------------------------------------------- 141
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTTREEVELSEEPGTNSTEATVTAIMTTAISKNKTKE 199
Query: 142 --PFGALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +VLGI I R + + L++ N L++A KIV
Sbjct: 200 YKVVGMYSDGINVLGLIVFCLVLGIVIG--------RKWEKGQILVDFFNALSDATMKIV 251
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y PIG+ LIA ++ + ++ +L V GLA+ + L+YF++++
Sbjct: 252 QIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSIVILPLIYFIIVRK 311
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 312 ---NPFQFAMGMAQALLTALMISSSSATLPVTFRCAEEKNRVDKRITRFVLPVGATINMD 368
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA + L++GQ +TI +TA ASIG AGVP G + + +VL +VGL
Sbjct: 369 GTALYEAVAAVFIAQLNDLDLSVGQIITISVTATAASIGAAGVPQPGLVTMVIVLSAVGL 428
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 PAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 464
>sp|P31597|EAT3_RABIT EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY
AMINO-ACID CARRIER 1) >gi|7447028|pir||S28902 glutamate
transport protein, high-affinity - rabbit
>gi|294480|gb|AAA31257.1| (L12411) high-affinity
glutamate transporter [Oryctolagus cuniculus]
>gi|383572|prf||1903293A Glu transporter [Oryctolagus
cuniculus]
Length = 524
Score = 215 bits (543), Expect = 6e-55
Identities = 143/462 (30%), Positives = 233/462 (49%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
+L ++ ++LG ++G+++ Y + + F G++ +R+LK++++P++ +S++ G
Sbjct: 20 LLLSTVVAVVLGIVIGVLVREYSNLSTLDKFYFAFPGEILMRMLKLVILPLIVSSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ V+YY T+ AV LGI++ PG + E G +
Sbjct: 80 AALDSNVSGKIGLRAVLYYFCTTIIAVILGIVLVVSIKPGVTQKVDEIDRTGSTPEVSTV 139
Query: 128 PPLVQTLLNIIPTN---------------------------------------------- 141
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTTREEVTASDDTGKNGTEESVTAVMTTAVSENRTKE 199
Query: 142 --PFGALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 YRVVGLYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIV 251
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y P+G+ LIA ++ + ++ +L V V GLA+ + L+YF++++
Sbjct: 252 QIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMVTVLSGLAIHSIVILPLIYFIVVRK 311
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 312 ---NPFRFAMGMTQALLTALMISSSSATLPVTFRCAEEKNRVDKRITRFVLPVGATINMD 368
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA M L++GQ +TI +TA ASIG AGVP AG + + +VL +VGL
Sbjct: 369 GTALYEAVAAVFIAQLNDMDLSIGQIITISVTATAASIGAAGVPQAGLVTMVIVLSAVGL 428
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RT+VNV GD GT IV K
Sbjct: 429 PAEDV------TLIIAVDWLLDRFRTVVNVLGDAFGTGIVEK 464
>sp|P37312|DCTA_ECOLI C4-DICARBOXYLATE TRANSPORT PROTEIN >gi|1073358|pir||S47749
C4-dicarboxylate transport protein dctA - Escherichia
coli >gi|466666|gb|AAB18505.1| (U00039) CG site No. 872
[Escherichia coli] >gi|1789947|gb|AAC76553.1| (AE000429)
uptake of C4-dicarboxylic acids [Escherichia coli K12]
Length = 428
Score = 215 bits (543), Expect = 6e-55
Identities = 130/417 (31%), Positives = 222/417 (53%), Gaps = 26/417 (6%)
Query: 13 LQKILIGLILGAI-VGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
L K L +L AI +G++LGH+ Y + + +KP GD FV+L+KM++ P++F ++V G A
Sbjct: 5 LFKSLYFQVLTAIAIGILLGHF-YPE-IGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIA 62
Query: 72 SISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI-----TLAEAGKQFQPK 125
+ + +GR G ++Y+ + S A+ +G+I+ + PGAG+ TL
Sbjct: 63 GMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYAD 122
Query: 126 QAPP--LVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETL 183
QA +V ++++IP + GA A+G +L + FA++ G A+ R+ + +
Sbjct: 123 QAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFAL--------HRLGSKGQLI 174
Query: 184 LNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQI 243
N I ++ ++ I+ +M+ APIG F +A + GV + +L ++ + Y+ L +
Sbjct: 175 FNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFV 234
Query: 244 LLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTL 303
+LV + K G KFI ++ +L T SS LP + E +G K + +
Sbjct: 235 VLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVI 294
Query: 304 PLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIML 363
P G + N+DGT++Y + FIA A + + Q+T+++ +L+S G AGV G+G I+L
Sbjct: 295 PTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVL 354
Query: 364 AMVLESVG-LPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
A L +VG LP+ A A+ILGID + R + N+ G+ T +VAK EL
Sbjct: 355 AATLSAVGHLPV------AGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKEL 405
>gi|4759126 solute carrier family 1 (glial high affinity glutamate
transporter), member 3; Solute carrier family 1 (glial
high affinity glutamate transporter), [Homo sapiens]
>gi|11416969|ref|XP_003876.1| solute carrier family 1
(glial high affinity glutamate transporter), member 3
[Homo sapiens] >gi|1169458|sp|P43003|EAT1_HUMAN
EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 1) (GLIAL GLUTAMATE
TRANSPORTER) (GLAST-1) >gi|542831|pir||JC2084
L-glutamate transport protein GLAST-1 (EAAT-1) - human
>gi|2135542|pir||S68860 L-glutamate transport protein
GLAST-1 (EAAT-1) - human >gi|487339|gb|AAA50428.1|
(U03504) excitatory amino acid transporter1 [Homo
sapiens] >gi|825504|dbj|BAA05462.1| (D26443) glutamate
transporter [Homo sapiens] >gi|825663|emb|CAA83507.1|
(Z31713) GLAST1 [Homo sapiens] >gi|746198|prf||2017269A
excitatory AA transporter:ISOTYPE=1 [Homo sapiens]
Length = 542
Score = 215 bits (542), Expect = 7e-55
Identities = 157/459 (34%), Positives = 231/459 (50%), Gaps = 88/459 (19%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG-------------ITLAEAG------- 119
++G++ VVYY+ T+ AV +GII+ I +PG G +T A+A
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNM 177
Query: 120 ----------KQFQ----------PKQA------------PPLVQTLLNI------IPTN 141
KQF+ P QA ++TL I +P +
Sbjct: 178 FPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGS 237
Query: 142 PFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGV 201
G A G V+ ++ F V+G +++ + L + L EA+ ++VA +
Sbjct: 238 VNGVNALGLVVFSMCFGFVIG------------NMKEQGQALREFFDSLNEAIMRLVAVI 285
Query: 202 MQYAPIGVFALIANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVF 254
M YAP+G+ LIA M GV + G+LA TV V VGL + ++V YF++ +
Sbjct: 286 MWYAPVGILFLIAGKIVEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK- 343
Query: 255 GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDG 313
+P FI A++TA T SSS TLP+T + + E+ G+ K + F LP+GATINMDG
Sbjct: 344 --NPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDG 401
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ + FIA L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP
Sbjct: 402 TALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLP 461
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
D +I+ +D LD RT NV GD G IV
Sbjct: 462 TDD------ITLIIAVDWFLDRLRTTTNVLGDSLGAGIV 494
>gb|AAD45401.1|AF067847_1 (AF067847) Na+-dependent glutamate transporter; GLAST [Canis
familiaris]
Length = 542
Score = 215 bits (542), Expect = 7e-55
Identities = 153/459 (33%), Positives = 227/459 (49%), Gaps = 88/459 (19%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG-------------ITLAEAGKQFQPKQ 126
++G++ VVYY+ T+ AV +GII+ I +PG G +T A+A
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVQVTAADAFLDLIRNM 177
Query: 127 APP---------------------------------------LVQTLLNI------IPTN 141
PP ++TL I +P +
Sbjct: 178 FPPNLVEACFKQFKTNYEKRSFKVPIQSNETLMAAVINNVSEAMETLTRITEELIPVPGS 237
Query: 142 PFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGV 201
G A G V+ ++ F +V+G +++ + L + L EA+ ++VA +
Sbjct: 238 VNGVNALGLVVFSMCFGLVIG------------NMKEQGQALREFFDSLNEAIMRLVAVI 285
Query: 202 MQYAPIGVFALIANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVF 254
M YAP+G+ LIA M GV + G+LA TV V VGL + ++V YF++ +
Sbjct: 286 MWYAPLGILFLIAGKIVEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK- 343
Query: 255 GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDG 313
+P FI A++TA T SSS TLP+T + + E+ G+ K + F LP+GATINMDG
Sbjct: 344 --NPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDG 401
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ + FIA L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP
Sbjct: 402 TALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLP 461
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
D +I+ +D LD RT NV GD G IV
Sbjct: 462 TDD------ITLIIAVDWFLDRLRTTTNVLGDSLGAGIV 494
>sp|P46411|EAT1_BOVIN EXCITATORY AMINO ACID TRANSPORTER 1 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 1) (GLAST1)
>gi|517081|dbj|BAA11527.1| (D82056) neuronal
sodium-dependent glutamate aspartate transporter [Bos
taurus]
Length = 542
Score = 215 bits (541), Expect = 1e-54
Identities = 156/459 (33%), Positives = 230/459 (49%), Gaps = 88/459 (19%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG-------------ITLAEAG------- 119
++G++ VVYY+ T+ AV +GII+ I +PG G +T A+A
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVQVTAADAFLDLIRNM 177
Query: 120 ----------KQF-------------QPKQA---------PPLVQTLLNI------IPTN 141
KQF QP + ++TL I +P +
Sbjct: 178 FPPNLVEACFKQFKTNYEKRSFKVPIQPNETLVGAVINNVSEAMETLTRITEELVPVPGS 237
Query: 142 PFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGV 201
G A G V+ ++ F V+G +++ + L + L EA+ ++VA +
Sbjct: 238 VNGVNALGLVVFSMCFGFVIG------------NMKEQGQALREFFDSLNEAIMRLVAVI 285
Query: 202 MQYAPIGVFALIANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVF 254
M YAP+G+ LIA M GV + G+LA TV V VGL + ++V YF++ +
Sbjct: 286 MWYAPLGILFLIAGKIVEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK- 343
Query: 255 GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDG 313
+P FI A++TA T SSS TLP+T + + E+ G+ K + F LP+GATINMDG
Sbjct: 344 --NPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDG 401
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ + FIA L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP
Sbjct: 402 TALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLP 461
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
D +I+ +D LD RT NV GD G IV
Sbjct: 462 TDD------ITLIIAVDWFLDRLRTTTNVLGDSLGAGIV 494
>pir||D75262 C4-dicarboxylate transport protein - Deinococcus radiodurans
(strain R1) >gi|6460349|gb|AAF12066.1|AE002082_2
(AE002082) C4-dicarboxylate transport protein
[Deinococcus radiodurans]
Length = 463
Score = 214 bits (540), Expect = 1e-54
Identities = 131/411 (31%), Positives = 217/411 (51%), Gaps = 29/411 (7%)
Query: 15 KILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+++I ++LG +VG + +G A +KP GD+FV+L+KM++ PI+FA++V G A +
Sbjct: 31 QVIIAIVLGILVGALFPKFGEA------LKPLGDIFVKLIKMVIAPIIFATVVSGVAHMR 84
Query: 75 PAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI-----TLAEAGKQFQPKQAP 128
R +GRVG K ++Y+ + S A+ +G+++ + PGAG+ TL AG + A
Sbjct: 85 DTRKVGRVGGKALIYFEVVSTLALIIGMVVMNVLRPGAGMNVDPATLDTAGLTKYTEAAG 144
Query: 129 PLV--QTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNA 186
+ +L IIP A G++LP + A++ G A+ R+ K + +L
Sbjct: 145 EMTVWDHILKIIPDTLVSAFTGGELLPVLLVALLFGFALM--------RLGKLGDQILYG 196
Query: 187 INGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLV 246
I+ L + ++ I+ +M+ APIG F +A + G+K + L + + Y+ L I +V
Sbjct: 197 IDALNQVVFVILGFIMRLAPIGAFGAMAFTVGKYGLKSLTSLGYLMGSFYLTCLLFIFVV 256
Query: 247 YFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLG 306
++ + G K I ++ +L T SS LP M E G K + +P G
Sbjct: 257 LGLIARAAGFSIFKLIRYIREELLIVLGTSSSESALPRLMMKLEHAGAEKSVVGLVVPTG 316
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
+ N+DGT++Y + FIA A L LG+QL+++ +L S G AGV G+G I LA
Sbjct: 317 YSFNLDGTSIYLTMAALFIAQATNTPLGLGEQLSLLAVLLLTSKGAAGVTGSGFITLAAT 376
Query: 367 LESVG-LPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 416
L +VG +P+ A A+ILGID + R + N G+ T +VA++E
Sbjct: 377 LGAVGHVPV------AGMALILGIDRFMSEARALTNFIGNAVATLVVARSE 421
>pir||D83498 C4-dicarboxylate transport protein PA1183 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9947108|gb|AAG04572.1|AE004548_6 (AE004548)
C4-dicarboxylate transport protein [Pseudomonas
aeruginosa]
Length = 436
Score = 214 bits (540), Expect = 1e-54
Identities = 124/423 (29%), Positives = 224/423 (52%), Gaps = 25/423 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P + + + +++ +G+ LGH+ AV +KPFGD FV+L+KM + PI+F ++V G
Sbjct: 5 PFYKSLYVQVLVAIAIGIALGHWYPETAVA--MKPFGDGFVKLIKMAIAPIIFCTVVTGI 62
Query: 71 ASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL-------AEAGKQF 122
A + + +G+ G ++Y+ + S A+ +G+++ + PGAG+ + ++
Sbjct: 63 AGMQSMKSVGKTGGMALLYFEVVSTVALIIGLVVVNVVQPGAGMHVDPNTLDTSKIAAYA 122
Query: 123 QPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
+ V L+N+IP GA ANG +L +FF+++ G A+ R+ +
Sbjct: 123 AAGEKQSTVDFLMNVIPGTVVGAFANGDILQVLFFSVLFGYAL--------HRLGSYGKP 174
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+ I ++ M+ I+ +M+ APIG F +A + + GV + +L ++ + Y+ L
Sbjct: 175 VFEFIERVSHVMFNIINVIMKVAPIGAFGAMAFTIGAYGVGSLVQLGQLMLCFYITCILF 234
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+L+V + + G ++FI ++ +L T SS LP + E +G +K +
Sbjct: 235 VLIVLGGIARAHGFSILRFIRYIREELLIVLGTSSSESALPRMIDKMEKLGCNKSVVGLV 294
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT++Y + FIA A + + Q+T++L ++AS G AGV G+G I+
Sbjct: 295 IPTGYSFNLDGTSIYLTMAAVFIAQATDTPMDITHQITLLLVLLIASKGAAGVTGSGFIV 354
Query: 363 LAMVLESVG-LPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
LA L +VG LP+ A A+ILGID + R + N+ G+ T +V+K +L E
Sbjct: 355 LAATLSAVGHLPV------AGLALILGIDRFMSEARALTNLVGNGVATVVVSKWCKQLDE 408
Query: 422 GII 424
G +
Sbjct: 409 GTL 411
>pir||I38560 glutamate transporter - human >gi|507898|gb|AAA68628.1| (U08989)
glutamate transporter [Homo sapiens]
>gi|1092518|prf||2024230A neuron-specific Glu
transporter III [Homo sapiens]
Length = 524
Score = 214 bits (539), Expect = 2e-54
Identities = 143/462 (30%), Positives = 230/462 (48%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
VL + ++LG G+++ + ++ + F G++ +R+LK++++P++ +S++ G
Sbjct: 20 VLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G+++VVYY T+ AV LGI++ PG + E G +
Sbjct: 80 AALDSNVSGKIGLRVVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKE 199
Query: 144 ----GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 YKIVGMYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIV 251
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y P+G+ LIA ++ + ++ +L V GLA+ + L+YF++++
Sbjct: 252 QIIMCYMPLGILFLIAGKIIEVEDWEIFAKLGLYMATVLTGLAIHSIVILPLIYFIVVRK 311
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 312 ---NPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMD 368
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA + L +GQ +TI +TA ASIG AGVP AG + + +VL +VGL
Sbjct: 369 GTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGL 428
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 PAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 464
>gb|AAF71701.1|AF208521_1 (AF208521) high-affinity Na+-dependent glutamate transporter
[Diploptera punctata]
Length = 481
Score = 213 bits (538), Expect = 2e-54
Identities = 140/438 (31%), Positives = 222/438 (49%), Gaps = 56/438 (12%)
Query: 17 LIGLILGAIVGLILGHY---GYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASI 73
+IG+ G +VG+I+ + G+ Y+ GD+F+++LK L++P++ AS++ +
Sbjct: 23 VIGVFGGVVVGVIMRNSREEGWTKREIMYVSYVGDIFLQMLKSLILPLIVASIITAIGGL 82
Query: 74 SPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG--ITLAEAGKQFQPKQAPPLV 131
+ G++G + + YY +T+ AV LG+I+ I +PG G ++ ++G L+
Sbjct: 83 DLSLSGKIGARAIAYYFITTVSAVILGMILVSIIHPGEGDVSSIHKSGTSRNVTTVDTLL 142
Query: 132 QTLLNIIPTNPFGALA---------------------------------NGKVLPTIFFA 158
+ N+ P N A + +L + FA
Sbjct: 143 DLIRNMFPPNLVQACTAQYQTQLIPPSDTEIIEKNLTLHDWEISHNFTTSSNILGLVVFA 202
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIA-NVM 217
V+GI + ++ + + LL L AM I V+ +PIG+F L+A ++
Sbjct: 203 TVMGITLA--------KMAEQGKPLLIFFETLGAAMLMITYWVIWVSPIGIFFLVAAKIL 254
Query: 218 ASQGVK-VVGELAKVTVAVYVGLALQILLVYFVLLKVFGID-PIKFISKAKDAMLTAFVT 275
+ + +VG+L + V VGL + +V V + P +FI A+ TAF T
Sbjct: 255 EMESFEAIVGQLGMYFMTVLVGLFIHGFIVIPVYYTICTRKLPFRFIVNMSQALFTAFGT 314
Query: 276 RSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLT 334
SS+ TLP++M E+ I K + F +P+GATINMDGTALY+ V FI+ GM L+
Sbjct: 315 GSSNATLPISMGCLEERNNIDKRVVRFVMPIGATINMDGTALYEAVAAIFISQVRGMALS 374
Query: 335 LGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILD 394
LGQ L I +TA ASIG AG+P AG + + MVL++VGLP D +I+ +D +LD
Sbjct: 375 LGQLLAISVTATAASIGAAGIPQAGLVTMVMVLDTVGLPPEDV------TLIITVDWLLD 428
Query: 395 MGRTMVNVTGDLTGTAIV 412
RTM+NV GD G IV
Sbjct: 429 RFRTMINVLGDSIGAGIV 446
>gb|AAC27511.3| (AF074911) neuronal and epithelial glutamate transporter [Homo
sapiens]
Length = 524
Score = 213 bits (537), Expect = 3e-54
Identities = 143/462 (30%), Positives = 230/462 (48%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
VL + ++LG G+++ + ++ + F G++ +R+LK++++P++ +S++ G
Sbjct: 20 VLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G+++VVYY T+ AV LGI++ PG + E G +
Sbjct: 80 AALDSNVSGKIGLRVVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKE 199
Query: 144 ----GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 YKIVGMYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIV 251
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y P+G+ LIA ++ + ++ +L V GLA+ + L+YF++++
Sbjct: 252 QIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRK 311
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 312 ---NPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMD 368
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA + L +GQ +TI +TA ASIG AGVP AG + + +VL +VGL
Sbjct: 369 GTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGL 428
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 PAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 464
>gi|4759122 solute carrier family 1 (neuronal/epithelial high affinity
glutamate transporter, system Xag), member 1; Human
glutamate transporter mRNA, complete cds; Solute carrier
family 1, member 1 (high-affinity glutamate transporter;
excitatory amino acid carri> >gi|2135092|pir||I38433
excitatory amino acid transporter3 - human
>gi|487343|gb|AAA50430.1| (U03506) excitatory amino acid
transporter3 [Homo sapiens] >gi|746200|prf||2017269C
excitatory AA transporter:ISOTYPE=3 [Homo sapiens]
Length = 525
Score = 212 bits (533), Expect = 8e-54
Identities = 143/462 (30%), Positives = 229/462 (48%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
VL + ++LG G+++ + ++ + F G++ +R+LK++++P++ +S++ G
Sbjct: 21 VLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGV 80
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ VVYY T+ AV LGI++ PG + E G +
Sbjct: 81 AALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTV 140
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 141 DAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKE 200
Query: 144 ----GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 201 YKIVGMYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIV 252
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y P+G+ LIA ++ + ++ +L V GLA+ + L+YF++++
Sbjct: 253 QIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRK 312
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 313 ---NPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMD 369
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA + L +GQ +TI +TA ASIG AGVP AG + + +VL +VGL
Sbjct: 370 GTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGL 429
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 430 PAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 465
>pir||T29633 hypothetical protein C12D12.2 - Caenorhabditis elegans
>gi|1255318|gb|AAA96079.1| (U51998) coded for by C.
elegans cDNA cm08h9; coded for by C. elegans cDNA cm9d6;
Similar to excitatory amino acid transporter
[Caenorhabditis elegans]
Length = 518
Score = 212 bits (533), Expect = 8e-54
Identities = 150/464 (32%), Positives = 226/464 (48%), Gaps = 72/464 (15%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
+ W++K L +L + ++LGA+ G +L + YI G+L + +LKM+++P
Sbjct: 48 VSWIRKNL---LLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILP 104
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
++ +SL+ G A + + G++G V YY+ T+A AV GI + + +PG E G
Sbjct: 105 LIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGT 164
Query: 121 QFQPKQAPP---LVQTLLNIIPTN---------------------------PFGALANGK 150
+ K L+ L N+ P N AL NG
Sbjct: 165 GTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGS 224
Query: 151 ---------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
VL I F I +GI+++ L + A ++ + + +
Sbjct: 225 LDYVKASVEYTSGMNVLGVIVFCIAIGISLSQL--------GQEAHVMVQFFVIMDKVIM 276
Query: 196 KIVAGVMQYAPIGVFALIANVMAS--QGVKVVGELAKVTVAVYVGLALQIL----LVYFV 249
K+V VM Y+P G+F LI + LA V V GLA+ L L++FV
Sbjct: 277 KLVMTVMWYSPFGIFCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFV 336
Query: 250 LLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGAT 308
K +P F+ A +TA T SSS TLP+T + E++G+ + + F LP+GAT
Sbjct: 337 TTKK---NPYVFMRGLFQAWITALGTASSSATLPITFNCLEENLGVDRRVTRFVLPVGAT 393
Query: 309 INMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLE 368
INMDGTALY+ V FIA G+HL+ GQ +T+ LTA LASIG A VP AG + + +VL
Sbjct: 394 INMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLT 453
Query: 369 SVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP+ D ++I+ +D +LD RT +NV GD G IV
Sbjct: 454 AVGLPVKDV------SLIVAVDWLLDRIRTSINVLGDAMGAGIV 491
>sp|Q10901|EAT1_CAEEL EXCITATORY AMINO ACID TRANSPORTER (SODIUM-DEPENDENT GLUTAMATE/
ASPARTATE TRANSPORTER) >gi|2133458|pir||JC5078 glutamate
transporter glut-2 - Caenorhabditis elegans
>gi|2340835|dbj|BAA21840.1| (D86741) glutamate
transporter [Caenorhabditis elegans]
>gi|4432967|dbj|BAA13164.1| (D86740) glutamate
transporter [Caenorhabditis elegans]
Length = 503
Score = 212 bits (533), Expect = 8e-54
Identities = 150/464 (32%), Positives = 226/464 (48%), Gaps = 72/464 (15%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
+ W++K L +L + ++LGA+ G +L + YI G+L + +LKM+++P
Sbjct: 13 VSWIRKNL---LLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILP 69
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
++ +SL+ G A + + G++G V YY+ T+A AV GI + + +PG E G
Sbjct: 70 LIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGT 129
Query: 121 QFQPKQAPP---LVQTLLNIIPTN---------------------------PFGALANGK 150
+ K L+ L N+ P N AL NG
Sbjct: 130 GTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGS 189
Query: 151 ---------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
VL I F I +GI+++ L + A ++ + + +
Sbjct: 190 LDYVKASVEYTSGMNVLGVIVFCIAIGISLSQL--------GQEAHVMVQFFVIMDKVIM 241
Query: 196 KIVAGVMQYAPIGVFALIANVMAS--QGVKVVGELAKVTVAVYVGLALQIL----LVYFV 249
K+V VM Y+P G+F LI + LA V V GLA+ L L++FV
Sbjct: 242 KLVMTVMWYSPFGIFCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFV 301
Query: 250 LLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGAT 308
K +P F+ A +TA T SSS TLP+T + E++G+ + + F LP+GAT
Sbjct: 302 TTKK---NPYVFMRGLFQAWITALGTASSSATLPITFNCLEENLGVDRRVTRFVLPVGAT 358
Query: 309 INMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLE 368
INMDGTALY+ V FIA G+HL+ GQ +T+ LTA LASIG A VP AG + + +VL
Sbjct: 359 INMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLT 418
Query: 369 SVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP+ D ++I+ +D +LD RT +NV GD G IV
Sbjct: 419 AVGLPVKDV------SLIVAVDWLLDRIRTSINVLGDAMGAGIV 456
>sp|O57321|EAT1_AMBTI EXCITATORY AMINO ACID TRANSPORTER 1 (SEAAT1)
>gi|2655015|gb|AAB88286.1| (AF018256) glutamate
transporter 1 [Ambystoma tigrinum]
Length = 543
Score = 212 bits (533), Expect = 8e-54
Identities = 157/461 (34%), Positives = 228/461 (49%), Gaps = 64/461 (13%)
Query: 17 LIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPA 76
+I +++G+I+G + Y Y G+L +R+L+MLV+P++ +SLV G A++
Sbjct: 55 VIAVVVGSILGFSVRSYHMTFRELKYFSFPGELLMRMLQMLVLPLIVSSLVTGMAALDSK 114
Query: 77 RLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGIT--LAEAGKQFQPKQAPPLVQTL 134
G++G++ VVYY+ T+ AV +GI++ I +PG G + GK A + +
Sbjct: 115 ASGKMGLRAVVYYMTTTVIAVFIGIVIVIIVHPGKGTKEHMHREGKIEPVTAADAFLDLI 174
Query: 135 LNIIPTNPFGALANGKVLPTIF----FAIVLGIAITYLMNSKDERVRKSAETLLN----- 185
N+ P N A K T + F + + T +M S V ++ ETL
Sbjct: 175 RNMFPPNMVEACF--KQFKTSYEKKIFKVTMPANETAVMTSVLNNVSEAMETLTKMREEM 232
Query: 186 -----AING---------------------------------LAEAMYKIVAGVMQYAPI 207
A+NG L EA+ ++VA +M YAPI
Sbjct: 233 IPVPGAVNGVNALGLVVFSMCFGLVIGNMKEQGKALKDFFDSLNEAIMRLVAVIMWYAPI 292
Query: 208 GVFALIANVMASQ---GVKVVGELAKVTVAVYVGLALQILLVYFVL-LKVFGIDPIKFIS 263
G+ LIA +A GV V G+L TV V +GL + ++V +L V +P FI
Sbjct: 293 GILFLIAGKIAEMEDMGV-VGGQLGMYTVTVIIGLLIHAVIVLPLLYFAVTRKNPWVFIG 351
Query: 264 KAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDGTALYQGVCT 322
A++TA T SSS TLP+T + E+ + K + F LP+GATINMDGTALY+ +
Sbjct: 352 GILQALITALGTSSSSATLPITFKCLEENNKVDKRVTRFVLPVGATINMDGTALYEALAA 411
Query: 323 FFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAA 382
FIA L GQ LTI +TA ASIG AG+P AG + + +VL SVGLP D
Sbjct: 412 IFIAQVNNYDLNFGQILTISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ 465
Query: 383 YAMILGIDAILDMGRTMVNVTGDLTGTAIVAK-TEGELKEG 422
+I+ +D LD RT NV GD G IV + EL+ G
Sbjct: 466 ITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELQSG 506
>sp|P43005|EAT3_HUMAN EXCITATORY AMINO ACID TRANSPORTER 3 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 3) (EXCITATORY
AMINO-ACID CARRIER 1)
Length = 524
Score = 212 bits (533), Expect = 8e-54
Identities = 143/462 (30%), Positives = 229/462 (48%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
VL + ++LG G+++ + ++ + F G++ +R+LK++++P++ +S++ G
Sbjct: 20 VLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ VVYY T+ AV LGI++ PG + E G +
Sbjct: 80 AALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKE 199
Query: 144 ----GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 YKIVGMYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIV 251
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y P+G+ LIA ++ + ++ +L V GLA+ + L+YF++++
Sbjct: 252 QIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRK 311
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 312 ---NPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMD 368
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA + L +GQ +TI +TA ASIG AGVP AG + + +VL +VGL
Sbjct: 369 GTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGL 428
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 PAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 464
>emb|CAB40566.1| (AJ132912) putative C-4-dicarboxylate carrier [Rhizobium galegae]
Length = 461
Score = 210 bits (529), Expect = 3e-53
Identities = 128/423 (30%), Positives = 219/423 (51%), Gaps = 29/423 (6%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P + + + ++ + G+++G++ Y D + +KP GD F++L+ M++ P++F ++ G
Sbjct: 14 PFYRHLYVQVLTAIVAGIMVGNF-YPD-LGASLKPLGDAFIKLVSMIIAPVIFLTVTTGI 71
Query: 71 ASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPK---- 125
A ++ + +GRV K ++Y+ + S A+ +G+++A I PGAG+ + A PK
Sbjct: 72 AGMADLKKVGRVAGKAILYFTVFSTLALAVGLLVANILRPGAGMHINPA--TLDPKAVAA 129
Query: 126 -----QAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
V L+ IIP GA A+G +L +F +I+ GI+I V
Sbjct: 130 YATNAHGTTAVSFLMKIIPNTIVGAFADGNILQVLFISILFGISIAM--------VGDRG 181
Query: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA 240
+ ++ ++ L E M+K+ A +M+ APIG F +A G+ + L + Y+
Sbjct: 182 QPVVRFLDALTEPMFKLTAVLMKAAPIGAFGAMAFTNGKYGIASLINLVMLIGTFYLTSL 241
Query: 241 LQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYS 300
L +L+V + + G I I+ K+ +L T SS LP M E +G + +
Sbjct: 242 LFVLVVLGAVARCNGFSVIALIAYIKEEILLVLGTSSSEAALPGLMAKMEQVGCKRSVVG 301
Query: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
+P G + N+DGT +Y + + FIA A LTL Q+ ++L A+L+S G+AG+ GAG
Sbjct: 302 LVVPTGYSFNLDGTNIYMTLASLFIAQATDTPLTLADQILLLLVAMLSSKGSAGITGAGF 361
Query: 361 IMLAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
I LA L +V +P+ A A+ILGID + R + N+ G+ T +VA EG+L
Sbjct: 362 ITLAATLSAVPSVPV------AGMALILGIDRFMSESRAITNLIGNAIATLVVANWEGDL 415
Query: 420 KEG 422
G
Sbjct: 416 DRG 418
>pir||S38353 glutamate transporter protein - human
Length = 543
Score = 209 bits (527), Expect = 4e-53
Identities = 156/460 (33%), Positives = 231/460 (49%), Gaps = 89/460 (19%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G I+G L Y + Y G+L +R+L+MLV+P++ +SLV G A++ G
Sbjct: 58 VIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASG 117
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG-------------ITLAEAG------- 119
++G++ VVYY+ T+ AV +GII+ I +PG G +T A+A
Sbjct: 118 KMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNM 177
Query: 120 ----------KQFQ----------PKQA------------PPLVQTLLNI------IPTN 141
KQF+ P QA ++TL I +P +
Sbjct: 178 FPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGS 237
Query: 142 PFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGV 201
G A G V+ ++ F V+G +++ + L + L EA+ ++VA +
Sbjct: 238 VNGVNALGLVVFSMCFGFVIG------------NMKEQGQALREFFDSLNEAIMRLVAVI 285
Query: 202 MQYAPIGVFALIANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVF 254
M YAP+G+ LIA M GV + G+LA TV V VGL + ++V YF++ +
Sbjct: 286 MWYAPVGILFLIAGKIVEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRK- 343
Query: 255 GIDPIKFISKAKDAMLTAFVTRSS-SGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMD 312
+P FI A++TA T SS + TLP+T + + E+ G+ K + F LP+GATINMD
Sbjct: 344 --NPWVFIGGLLQALITALGTSSSCTATLPITFKCLEENNGVDKRVTRFVLPVGATINMD 401
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ + FIA L GQ +TI +TA ASIG AG+P AG + + +VL SVGL
Sbjct: 402 GTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGL 461
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
P D +I+ +D LD RT NV GD G IV
Sbjct: 462 PTDD------ITLIIAVDWFLDRLRTTTNVLGDSLGAGIV 495
>gb|AAB41909.1| (U35250) CeGlt-2 [Caenorhabditis elegans]
Length = 503
Score = 208 bits (525), Expect = 7e-53
Identities = 149/464 (32%), Positives = 227/464 (48%), Gaps = 72/464 (15%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
+ W++K L +L + ++LGA+ G +L + YI G+L + +LKM++ P
Sbjct: 13 VSWIRKNL---LLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMIPP 69
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
++ +SL+ G A + + G++G V YY+ T+A AV GI + + +PG E G
Sbjct: 70 LIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGT 129
Query: 121 QFQPKQAPP---LVQTLLNIIPTN---------------------------PFGALANGK 150
+ K L+ L N+ P N AL NG
Sbjct: 130 GTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGS 189
Query: 151 ---------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
VL I F I +GI+++ L + A ++ + + +
Sbjct: 190 LDYVKASVEYTSGMNVLGVIVFCIAIGISLSQL--------GQEAHVMVQFFVIMDKVIM 241
Query: 196 KIVAGVMQYAPIGVFALI-ANVMASQGVK-VVGELAKVTVAVYVGLALQIL----LVYFV 249
K+V VM Y+P G+F LI ++ ++ LA V V GLA+ L L++FV
Sbjct: 242 KLVMTVMWYSPFGIFCLIMGKILEIHDLENTTRMLAMYMVTVLSGLAIHSLISLPLIFFV 301
Query: 250 LLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGAT 308
K +P F+ A +T T SSS TLP+T + E++G+ + + F LP+GAT
Sbjct: 302 TTKK---NPYVFMRGLFQAWITGLGTASSSATLPITFNCLEENLGVDRRVTRFVLPVGAT 358
Query: 309 INMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLE 368
INMDGTALY+ V FIA G+HL+ GQ +T+ LTA LASIG A VP AG + + +VL
Sbjct: 359 INMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLT 418
Query: 369 SVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP+ D ++I+ +D +LD RT +NV GD G IV
Sbjct: 419 AVGLPVKDV------SLIVAVDWLLDRIRTSINVLGDAMGAGIV 456
>gb|AAB41910.1| (U35250) CeGlt-1 [Caenorhabditis elegans]
Length = 492
Score = 208 bits (525), Expect = 7e-53
Identities = 149/464 (32%), Positives = 227/464 (48%), Gaps = 72/464 (15%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
+ W++K L +L + ++LGA+ G +L + YI G+L + +LKM++ P
Sbjct: 2 VSWIRKNL---LLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMIPP 58
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
++ +SL+ G A + + G++G V YY+ T+A AV GI + + +PG E G
Sbjct: 59 LIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGT 118
Query: 121 QFQPKQAPP---LVQTLLNIIPTN---------------------------PFGALANGK 150
+ K L+ L N+ P N AL NG
Sbjct: 119 GTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGS 178
Query: 151 ---------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
VL I F I +GI+++ L + A ++ + + +
Sbjct: 179 LDYVKASVEYTSGMNVLGVIVFCIAIGISLSQL--------GQEAHVMVQFFVIMDKVIM 230
Query: 196 KIVAGVMQYAPIGVFALI-ANVMASQGVK-VVGELAKVTVAVYVGLALQIL----LVYFV 249
K+V VM Y+P G+F LI ++ ++ LA V V GLA+ L L++FV
Sbjct: 231 KLVMTVMWYSPFGIFCLIMGKILEIHDLENTTRMLAMYMVTVLSGLAIHSLISLPLIFFV 290
Query: 250 LLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGAT 308
K +P F+ A +T T SSS TLP+T + E++G+ + + F LP+GAT
Sbjct: 291 TTKK---NPYVFMRGLFQAWITGLGTASSSATLPITFNCLEENLGVDRRVTRFVLPVGAT 347
Query: 309 INMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLE 368
INMDGTALY+ V FIA G+HL+ GQ +T+ LTA LASIG A VP AG + + +VL
Sbjct: 348 INMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLT 407
Query: 369 SVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP+ D ++I+ +D +LD RT +NV GD G IV
Sbjct: 408 AVGLPVKDV------SLIVAVDWLLDRIRTSINVLGDAMGAGIV 445
>pir||A54856 high affinity glutamate transporter - human
>gi|517021|gb|AAA53215.1| (U06469) HEAAC1 [Homo sapiens]
Length = 524
Score = 208 bits (525), Expect = 7e-53
Identities = 142/462 (30%), Positives = 228/462 (48%), Gaps = 76/462 (16%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMPIVFASLVVGA 70
VL + ++LG G+++ + ++ + F G++ +R+LK++++P++ +S++ G
Sbjct: 20 VLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGV 79
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQA 127
A++ G++G++ V+YY T+ AV LGI++ PG + E G +
Sbjct: 80 AALDSNVSGKIGLRAVLYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTV 139
Query: 128 PPLVQTLLNIIPTNPF-------------------------------------------- 143
++ + N+ P N
Sbjct: 140 DAMLDLIRNMFPENLVQACFQQYKTKREEVNPASDPEMNMTEESFTAVMTTAISKNKTKE 199
Query: 144 ----GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
G ++G VL I F +V G+ I ++ + + L++ N L++A KIV
Sbjct: 200 YKIVGMYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIV 251
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKV 253
+M Y P G+ LIA ++ + ++ +L V GLA+ + L+YF++++
Sbjct: 252 QIIMCYMPHGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRK 311
Query: 254 FGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMD 312
+P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMD
Sbjct: 312 ---NPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMD 368
Query: 313 GTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGL 372
GTALY+ V FIA + L +GQ +TI +TA ASIG AGVP AG + + +VL +VGL
Sbjct: 369 GTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGL 428
Query: 373 PLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
P D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 429 PAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 464
>sp|Q25605|EAT_ONCVO EXCITATORY AMINO ACID TRANSPORTER (SODIUM-DEPENDENT GLUTAMATE/
ASPARTATE TRANSPORTER) >gi|1045482|gb|AAB41937.1|
(U35251) OvGlt-1 [Onchocerca volvulus]
Length = 492
Score = 206 bits (520), Expect = 3e-52
Identities = 148/464 (31%), Positives = 225/464 (47%), Gaps = 72/464 (15%)
Query: 1 MGWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMP 60
+ W++K L +L + ++LGA+ G +L + YI G+L + +LKM+++P
Sbjct: 2 VSWIRKNL---LLVLTVSSVVLGALCGFLLRGLQLSPQNIMYISFPGELLMHMLKMMILP 58
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
++ +SL+ G A + + G++G V YY+ T+A AV GI + + +PG E G
Sbjct: 59 LIMSSLISGLAQLDARQSGKLGSLAVTYYMFTTAVAVVTGIFLVLVIHPGDPTIKKEIGT 118
Query: 121 QFQPKQAPP---LVQTLLNIIPTN---------------------------PFGALANGK 150
+ K L+ L N+ P N AL NG
Sbjct: 119 GTEGKTVSTVDTLLDLLRNMFPENVVQATFQQVQTKYIKVRPKVVKNNDSATLAALNNGS 178
Query: 151 ---------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
VL I F I +GI+++ L + A ++ + + +
Sbjct: 179 LDYVKASVEYTSGMNVLGVIVFCIAIGISLSQL--------GQEAHVMVQFFVIMDKVIM 230
Query: 196 KIVAGVMQYAPIGVFALIANVMAS--QGVKVVGELAKVTVAVYVGLALQIL----LVYFV 249
K+V VM Y+P G+ LI + LA V V GLA+ L L++FV
Sbjct: 231 KLVMTVMWYSPFGILCLIMGKILEIHDLADTARMLAMYMVTVLSGLAIHSLISLPLIFFV 290
Query: 250 LLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVT-MRVAEDMGISKGIYSFTLPLGAT 308
K +P F+ A +T T SSS TLP+T + + E++G+ + + F LP+GAT
Sbjct: 291 TTKK---NPYVFMRGLFQAWITGLGTASSSDTLPITYICLEENLGVDRRVTRFVLPVGAT 347
Query: 309 INMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLE 368
INMDGTALY+ V FIA G+HL+ GQ +T+ LTA LASIG A VP AG + + +VL
Sbjct: 348 INMDGTALYEAVAAIFIAQINGVHLSFGQVVTVSLTATLASIGAASVPSAGLVTMLLVLT 407
Query: 369 SVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP+ D ++I+ +D +LD RT +NV GD G IV
Sbjct: 408 AVGLPVKDV------SLIVAVDWLLDRIRTSINVLGDAMGAGIV 445
>sp|P31596|EAT2_RAT EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 2) (GLUT-R) (GLT-1)
>gi|386355|gb|AAB27233.1| L-glutamate transporter, GLT-1
[rats, brain, Peptide, 573 aa]
Length = 573
Score = 206 bits (518), Expect = 5e-52
Identities = 154/465 (33%), Positives = 230/465 (49%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ-------- 121
+ + GR+G + +VYY+ T+ A LG+I+ +PG + G
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP L+ +N P
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNEAPEE 224
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 225 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 276
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 277 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 336
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 337 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 393
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 394 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 453
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 454 TAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 492
>gb|AAA93061.1| (U15098) GluT [Rattus norvegicus]
Length = 573
Score = 206 bits (518), Expect = 5e-52
Identities = 154/465 (33%), Positives = 230/465 (49%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ-------- 121
+ + GR+G + +VYY+ T+ A LG+I+ +PG + G
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP L+ +N P
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNEAPEE 224
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 225 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 276
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 277 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 336
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 337 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 393
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 394 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 453
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 454 TAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 492
>gb|AAG13411.1|AF297648_1 (AF297648) sodium-dependent high affinity glutamate transporter
GLT-1A [Rattus norvegicus]
Length = 570
Score = 206 bits (518), Expect = 5e-52
Identities = 154/465 (33%), Positives = 230/465 (49%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 43 LLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 101
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ-------- 121
+ + GR+G + +VYY+ T+ A LG+I+ +PG + G
Sbjct: 102 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 161
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP L+ +N P
Sbjct: 162 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNEAPEE 221
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 222 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 273
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 274 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 333
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 334 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 390
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 391 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 450
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 451 TAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 489
>pir||T27128 hypothetical protein Y53C12A.2 - Caenorhabditis elegans
>gi|3881128|emb|CAB16485.1| (Z99277) predicted using
Genefinder~Similarity to Human excitatory amino acid
transporter 2 (SW:P43004), contains similarity to Pfam
domain: PF00375 (Sodium:dicarboxylate symporter family),
Score=559.5, E-value=7.1e-165, N=1~cDNA EST yk11d10.5
comes fr>
Length = 491
Score = 206 bits (518), Expect = 5e-52
Identities = 144/448 (32%), Positives = 222/448 (49%), Gaps = 58/448 (12%)
Query: 3 WLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIV 62
WL K + +L + G+++G I+G +L + V Y+ G+LF+ +LK +V+P++
Sbjct: 15 WLTKNM---LLLMTMAGIVMGVIIGGVLRTADPSPDVIRYVGFPGELFMNMLKAMVLPLI 71
Query: 63 FASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPG-----AGITLAE 117
AS+V G + + GR+G + V+YY +T+ AV LGII+ I PG + +
Sbjct: 72 AASIVSGLSQLDGKTSGRLGSRAVMYYAITTTHAVILGIIVVSIIQPGDPTIKQKMGYDK 131
Query: 118 AGKQFQPKQAPPLVQTLLNIIPTNPFGAL-------------ANG--------------K 150
G+ A + N P N A +NG
Sbjct: 132 EGEAANVSAAQKFLDLFRNAFPENIMRATFSQVQTNYINQTHSNGATHEVLHTGYVDGMN 191
Query: 151 VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVF 210
VL I F IV+G+ ++ R+ + A+ L N + L + ++V +M PIG+
Sbjct: 192 VLGIIVFCIVMGLVVS--------RIGEEAKALANLFHALDVVITRMVMLIMWLGPIGIP 243
Query: 211 ALIANVM--ASQGVKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISK 264
+LIA M S L V +GLA+Q + L+YF+ + +P F+
Sbjct: 244 SLIAQKMLEVSDLWLTARMLGLFVFTVILGLAIQAFITLPLIYFIGTR---HNPYTFLKG 300
Query: 265 AKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFF 324
A++TA T SS+ +LPVT R +GI + F LP+GA +NMDGTALY+ + F
Sbjct: 301 LGQAIMTALGTSSSAASLPVTFRCLNKLGIDPRVTKFVLPVGAMVNMDGTALYEATASIF 360
Query: 325 IANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYA 384
IA G+ L++GQ +T+ +TA LASIG A +P AG + + +VL ++GLP D +
Sbjct: 361 IAQMNGLELSIGQIVTVSITATLASIGAASIPSAGLVTMLIVLTALGLPAND------IS 414
Query: 385 MILGIDAILDMGRTMVNVTGDLTGTAIV 412
+IL +D LD RT VNV GD G V
Sbjct: 415 LILAVDWFLDRLRTSVNVIGDALGCGFV 442
>gb|AAA19438.1| (L19444) neutral amino acid transporter [Homo sapiens]
Length = 532
Score = 205 bits (515), Expect = 1e-51
Identities = 140/441 (31%), Positives = 220/441 (49%), Gaps = 64/441 (14%)
Query: 19 GLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARL 78
G++ GA +G L + TY+ G++ +R+L+M+++P+V SLV GAAS+ + L
Sbjct: 51 GVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCL 110
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI-TLAEAGKQFQPKQAPPLVQTLL-- 135
GR+G V Y+ LT+ A L + +A I PG+G TL + + PP+ + +
Sbjct: 111 GRLGGIAVAYFGLTTLTASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDS 170
Query: 136 ------NIIPTN------------------------------PFGALANG-KVLPTIFFA 158
N+ P+N P G G +L + FA
Sbjct: 171 FLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFA 230
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMA 218
+VLG+A+ +++ E L+ N L EA +V+ +M Y P+G+ L+ + +
Sbjct: 231 LVLGVAL--------KKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV 282
Query: 219 SQG--VKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTA 272
+ +V L K A +G + + L+YFV + +P +F+ TA
Sbjct: 283 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRK---NPFRFLLGLLAPFATA 339
Query: 273 FVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGM 331
F T SSS TLP M+ + E+ G+ K I F LP+GAT+NMDG A++Q V FIA +
Sbjct: 340 FATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNV 399
Query: 332 HLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDA 391
L GQ TI++TA +S+G AGVP G + +A++LE++GLP D +IL +D
Sbjct: 400 ELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHD------LPLILAVDW 453
Query: 392 ILDMGRTMVNVTGDLTGTAIV 412
I+D T+VNV GD G I+
Sbjct: 454 IVDRTTTVVNVEGDALGAGIL 474
>gi|11430506 solute carrier family 1 (glutamate/neutral amino acid transporter),
member 4 [Homo sapiens] >gi|1173365|sp|P43007|SATT_HUMAN
NEUTRAL AMINO ACID TRANSPORTER A (SATT)
(ALANINE/SERINE/CYSTEINE/ THREONINE TRANSPORTER) (ASCT1)
>gi|2135823|pir||I37188 neutral amino acid transporter
ASCT1 - human >gi|603656|gb|AAC51349.1| (U05235) neutral
amino acid transporter [Homo sapiens]
>gi|6094667|gb|AAF03519.1|AC007386_2 (AC007386) match to
neutral amino acid transporter, ASCT1 [Homo sapiens]
Length = 532
Score = 205 bits (515), Expect = 1e-51
Identities = 140/441 (31%), Positives = 220/441 (49%), Gaps = 64/441 (14%)
Query: 19 GLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARL 78
G++ GA +G L + TY+ G++ +R+L+M+++P+V SLV GAAS+ + L
Sbjct: 51 GVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCL 110
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI-TLAEAGKQFQPKQAPPLVQTLL-- 135
GR+G V Y+ LT+ A L + +A I PG+G TL + + PP+ + +
Sbjct: 111 GRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDS 170
Query: 136 ------NIIPTN------------------------------PFGALANG-KVLPTIFFA 158
N+ P+N P G G +L + FA
Sbjct: 171 FLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFA 230
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMA 218
+VLG+A+ +++ E L+ N L EA +V+ +M Y P+G+ L+ + +
Sbjct: 231 LVLGVAL--------KKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV 282
Query: 219 SQG--VKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTA 272
+ +V L K A +G + + L+YFV + +P +F+ TA
Sbjct: 283 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRK---NPFRFLLGLLAPFATA 339
Query: 273 FVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGM 331
F T SSS TLP M+ + E+ G+ K I F LP+GAT+NMDG A++Q V FIA +
Sbjct: 340 FATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNV 399
Query: 332 HLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDA 391
L GQ TI++TA +S+G AGVP G + +A++LE++GLP D +IL +D
Sbjct: 400 ELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHD------LPLILAVDW 453
Query: 392 ILDMGRTMVNVTGDLTGTAIV 412
I+D T+VNV GD G I+
Sbjct: 454 IVDRTTTVVNVEGDALGAGIL 474
>dbj|BAA94861.1| (AB026689) hASCT1 [Homo sapiens]
Length = 532
Score = 205 bits (515), Expect = 1e-51
Identities = 140/441 (31%), Positives = 220/441 (49%), Gaps = 64/441 (14%)
Query: 19 GLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARL 78
G++ GA +G L + TY+ G++ +R+L+M+++P+V SLV GAAS+ + L
Sbjct: 51 GVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCL 110
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG--------ITLAEAGKQFQPKQA-PP 129
GR+G V Y+ LT+ A L + +A I PG+G + L ++G PK+
Sbjct: 111 GRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPSPVPKETVDS 170
Query: 130 LVQTLLNIIPTN------------------------------PFGALANG-KVLPTIFFA 158
+ N+ P+N P G G +L + FA
Sbjct: 171 FLDLARNLFPSNLGVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFA 230
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMA 218
+VLG+A+ +++ E L+ N L EA +V+ +M Y P+G+ L+ + +
Sbjct: 231 LVLGVAL--------KKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV 282
Query: 219 SQG--VKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTA 272
+ +V L K A +G + + L+YFV + +P +F+ TA
Sbjct: 283 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRK---NPFRFLLGLLAPFATA 339
Query: 273 FVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGM 331
F T SSS TLP M+ + E+ G+ K I F LP+GAT+NMDG A++Q V FIA +
Sbjct: 340 FATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNV 399
Query: 332 HLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDA 391
L GQ TI++TA +S+G AGVP G + +A++LE++GLP D +IL +D
Sbjct: 400 ELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHD------LPLILAVDW 453
Query: 392 ILDMGRTMVNVTGDLTGTAIV 412
I+D T+VNV GD G I+
Sbjct: 454 IVDRTTTVVNVEGDALGAGIL 474
>gi|4506995 solute carrier family 1 (glutamate/neutral amino acid transporter),
member 4; Solute carrier family 1 (glutamate/neutral
amino acid transporter), [Homo sapiens]
>gi|2135822|pir||I55389 neutral amino acid transporter -
human >gi|348012|gb|AAA02761.1| (L14595) neutral amino
acid transporter [Homo sapiens]
Length = 532
Score = 204 bits (513), Expect = 2e-51
Identities = 140/441 (31%), Positives = 220/441 (49%), Gaps = 64/441 (14%)
Query: 19 GLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARL 78
G++ GA +G L + TY+ G++ +R+L+M+++P+V SLV GAAS+ + L
Sbjct: 51 GVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCL 110
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI-TLAEAGKQFQPKQAPPLVQTLL-- 135
GR+G V Y+ LT+ A L + +A I PG+G TL + + PP+ + +
Sbjct: 111 GRLGGIRVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDS 170
Query: 136 ------NIIPTN------------------------------PFGALANG-KVLPTIFFA 158
N+ P+N P G G +L + FA
Sbjct: 171 FLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFA 230
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMA 218
+VLG+A+ +++ E L+ N L EA +V+ +M Y P+G+ L+ + +
Sbjct: 231 LVLGVAL--------KKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIV 282
Query: 219 SQG--VKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTA 272
+ +V L K A +G + + L+YFV + +P +F+ TA
Sbjct: 283 EMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRK---NPFRFLLGLLAPFATA 339
Query: 273 FVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGM 331
F T SSS TLP M+ + E+ G+ K I F LP+GAT+NMDG A++Q V FIA +
Sbjct: 340 FATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNI 399
Query: 332 HLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDA 391
L GQ TI++TA +S+G AGVP G + +A++LE++GLP D +IL +D
Sbjct: 400 ELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHD------LPLILAVDW 453
Query: 392 ILDMGRTMVNVTGDLTGTAIV 412
I+D T+VNV GD G I+
Sbjct: 454 IVDRTTTVVNVEGDALGAGIL 474
>gi|9256644 neutral amino acid transporter [Mus musculus]
>gi|3024586|sp|O35874|SATT_MOUSE NEUTRAL AMINO ACID
TRANSPORTER A (SATT) (ALANINE/SERINE/CYSTEINE/ THREONINE
TRANSPORTER) (ASCT1) >gi|2459561|gb|AAB71740.1| (U75215)
mASCT1 [Mus musculus]
Length = 532
Score = 203 bits (511), Expect = 3e-51
Identities = 149/458 (32%), Positives = 222/458 (47%), Gaps = 72/458 (15%)
Query: 19 GLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARL 78
G+++GA +G L TY+ G++ +R+L+M+++P+V SLV GAAS+ + L
Sbjct: 51 GVLVGAGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASSL 110
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPPLVQT----- 133
GR+G V Y+ LT+ A L + +A I PGAG ++ PP V
Sbjct: 111 GRLGGIAVAYFGLTTLSASALAVALAFIIKPGAGAQTLQSSSLGLENSGPPPVSKETVDS 170
Query: 134 ----LLNIIPTNPFGAL---------------ANGKV----------------LPTIFFA 158
L N+ P+N A ++G V L + FA
Sbjct: 171 FLDLLRNLFPSNLVVAAFTTSATDYTVVTHNTSSGNVTKEKIPVVTDVEGMNILGLVLFA 230
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMA 218
+VLG+A+ +++ E L+ N EA +V+ +M Y PIG+ LI + +
Sbjct: 231 LVLGVAL--------KKLGPEGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGSKIV 282
Query: 219 SQG--VKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTA 272
V +V L K A +G + + LVYF + +P F+ TA
Sbjct: 283 EMKDIVMLVTSLGKYIFASMLGHVIHGGIVLPLVYFAFTRK---NPFTFLLGLLTPFATA 339
Query: 273 FVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGM 331
F T SSS TLP M+ + E+ G+ K I F LP+GAT+NMDG A++Q V FIA +
Sbjct: 340 FATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNV 399
Query: 332 HLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDA 391
L GQ TI++TA +S+G AGVP G + +A++LE++GLP D ++IL +D
Sbjct: 400 DLNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHD------LSLILAVDW 453
Query: 392 ILDMGRTMVNVTGDLTGTAI--------VAKTEGELKE 421
I+D T+VNV GD G I V K E EL+E
Sbjct: 454 IVDRTTTVVNVEGDALGAGILNHLNQKVVKKGEQELQE 491
>gb|AAG02179.1|AF246129_1 (AF246129) neutral amino acid transporter ASCT1 [Mus musculus]
Length = 532
Score = 203 bits (511), Expect = 3e-51
Identities = 149/458 (32%), Positives = 222/458 (47%), Gaps = 72/458 (15%)
Query: 19 GLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARL 78
G+++GA +G L TY+ G++ +R+L+M+++P+V SLV GAAS+ + L
Sbjct: 51 GVLVGAGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASSL 110
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPPLVQT----- 133
GR+G V Y+ LT+ A L + +A I PGAG ++ PP V
Sbjct: 111 GRLGGIAVAYFGLTTLSASALAVALAFIIKPGAGAQTLQSSSLGLENSGPPPVSKETVDS 170
Query: 134 ----LLNIIPTNPFGAL---------------ANGKV----------------LPTIFFA 158
L N+ P+N A ++G V L + FA
Sbjct: 171 FLDLLRNLFPSNLVVAAFTTSATDYTVVTHNTSSGNVTKEKIPVVTDVEGMNILGLVLFA 230
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMA 218
+VLG+A+ +++ E L+ N EA +V+ +M Y PIG+ LI + +
Sbjct: 231 LVLGVAL--------KKLGPEGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGSKIV 282
Query: 219 SQG--VKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTA 272
V +V L K A +G + + LVYF + +P F+ TA
Sbjct: 283 EMKDIVMLVTSLGKYIFASMLGHVIHGGIVLPLVYFAFTRK---NPFTFLLGLLTPFATA 339
Query: 273 FVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGM 331
F T SSS TLP M+ + E+ G+ K I F LP+GAT+NMDG A++Q V FIA +
Sbjct: 340 FATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNV 399
Query: 332 HLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDA 391
L GQ TI++TA +S+G AGVP G + +A++LE++GLP D ++IL +D
Sbjct: 400 DLNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHD------LSLILAVDW 453
Query: 392 ILDMGRTMVNVTGDLTGTAI--------VAKTEGELKE 421
I+D T+VNV GD G I V K E EL+E
Sbjct: 454 IVDRTTTVVNVEGDALGAGILNHLNQKVVKKGEQELQE 491
>gb|AAB84380.1| (AF003006) high-affinity Na+-dependent glutamate transporter
[Trichoplusia ni]
Length = 479
Score = 202 bits (509), Expect = 6e-51
Identities = 142/448 (31%), Positives = 226/448 (49%), Gaps = 62/448 (13%)
Query: 17 LIGLILGAIVGLILGHYGYADAVKT--YIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+IG+I G+++G L G+ + + Y + G+LF+R+LK L++P++ +S+V S+
Sbjct: 24 IIGVIAGSLLGCGLRFSGHEWSRRDVMYFQYPGELFLRMLKSLIVPLLVSSIVSAIGSLD 83
Query: 75 PARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPPLVQTL 134
+ G+VG++ ++YY+ T+ AV LGI + PG T + + TL
Sbjct: 84 LSLSGKVGLRAIIYYMTTTICAVMLGIALVTTIKPGKETTYTQPNATKVISKDTLTSDTL 143
Query: 135 L----NIIPTNPFGAL--------------------------------ANGKVLPTIFFA 158
L N+ P N A + VL + F+
Sbjct: 144 LDLIRNVFPENLAQATIASYRTKLIYDKNDTKSRLGELETYQIQGEYQSGSNVLGLVCFS 203
Query: 159 IVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALI-ANVM 217
IVLGI + ++ + A L + + L+EAM I V+ +P+GVF L+ A +M
Sbjct: 204 IVLGITLG--------KMGEKARPLQDFFHSLSEAMMIITGWVIWLSPLGVFFLVTAKIM 255
Query: 218 ASQGV-KVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTA 272
+VG L K V +GL L + +++ + K P K+I+K M TA
Sbjct: 256 EIDDFGDLVGRLGKYFFTVLLGLFLHGFGTLRILFILATKKL---PCKYIAKMGQVMATA 312
Query: 273 FVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMH 332
F T SSS T+P+T+ +DMG+ I F +P+GATINMDGTALY+ V FIA +
Sbjct: 313 FGTASSSATMPITIGCCDDMGLDPRITRFVIPIGATINMDGTALYEAVAAIFIAQLRKVE 372
Query: 333 LTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAI 392
++ G+ + + +TA ASIG AG+P AG + + MVL++V LP D ++IL +D +
Sbjct: 373 MSFGKIIAVSVTATAASIGAAGIPQAGLVTMVMVLDTVNLPAEDV------SLILAVDWL 426
Query: 393 LDMGRTMVNVTGDLTGTAIVAK-TEGEL 419
LD RT +NV D G IV ++G++
Sbjct: 427 LDRFRTTINVVCDALGAIIVTSLSQGDI 454
>sp|P43006|EAT2_MOUSE EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 2)
>gi|1083314|pir||A55676 excitatory amino acid
transporter EEAT2 - mouse >gi|607866|gb|AAA77673.1|
(U11763) excitatory amino acid transporter 2 [Mus
musculus] >gi|984638|dbj|BAA07854.1| (D43796) glutamate
transporter MGLT1 [Mus musculus]
>gi|2668398|dbj|BAA23770.1| (AB007810) mGLT-1 [Mus
musculus] >gi|1098050|prf||2115216A Glu
transporter:ISOTYPE=MGLT1 [Mus musculus]
Length = 572
Score = 202 bits (509), Expect = 6e-51
Identities = 154/465 (33%), Positives = 229/465 (49%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP ++ +N P
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEE 224
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 225 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 276
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 277 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 336
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 337 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 393
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 394 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 453
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 454 TAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 492
>dbj|BAA23771.1| (AB007811) mGLT-1A [Mus musculus]
Length = 569
Score = 202 bits (509), Expect = 6e-51
Identities = 154/465 (33%), Positives = 229/465 (49%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 43 LLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 101
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 102 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 161
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP ++ +N P
Sbjct: 162 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEE 221
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 222 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 273
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 274 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 333
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 334 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 390
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 391 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 450
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 451 TAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 489
>gi|7106409 solute carrier family 1, member 2; glial high affinity glutamate
transporter [Mus musculus] >gi|2668402|dbj|BAA23772.1|
(AB007812) mGLT-1B [Mus musculus]
Length = 558
Score = 202 bits (509), Expect = 6e-51
Identities = 154/465 (33%), Positives = 229/465 (49%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 43 LLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 101
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 102 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 161
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP ++ +N P
Sbjct: 162 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEE 221
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 222 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 273
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 274 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 333
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 334 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 390
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 391 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 450
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 451 TAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 489
>pir||JV0092 glutamate-aspartate carrier protein - Escherichia coli
Length = 395
Score = 202 bits (509), Expect = 6e-51
Identities = 121/383 (31%), Positives = 218/383 (56%), Gaps = 26/383 (6%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADA----VKTYIKPFGDLFVRLLKMLVMPI 61
K ++F + +IL ++LG ++G L HY ++D+ V + P GD+F+ L+KM+V+PI
Sbjct: 2 KNIKFSLAWQILFAMVLGILLGSYL-HY-HSDSRDWLVVNLLSPAGDIFIHLIKMIVVPI 59
Query: 62 VFASLVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG- 119
V ++LVVG A + A+ LGR+G K ++Y+ + + A+ LG + +F PGAG+ +++
Sbjct: 60 VISTLVVGIAGVGDAKQLGRIGAKTIIYFEVITTVAIILGSLWRTVFQPGAGVDMSQLAT 119
Query: 120 ---KQFQP------KQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMN 170
++Q + ++ T+L+++PTN ++A G++LP IFF+++ G+ ++ L
Sbjct: 120 VDISKYQSTTEAVQSSSHGIMGTILSLVPTNIVASMAKGEMLPIIFFSVLFGLGLSSLPA 179
Query: 171 SKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAK 230
+ E L+ ++E M+K+ VM+YAP+GVFALIA +A+ G + LAK
Sbjct: 180 TH-------REPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFSSLWPLAK 232
Query: 231 VTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAE 290
+ + V+ + L+V ++ ++ G+ I KD ++ A+ T SS +P MR +
Sbjct: 233 LVLLVHFAILFFALVVLGIVARLCGLSVWILIRILKDELILAYSTASSESVVPRHMRRWK 292
Query: 291 DM-GISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLAS 349
+ S+ P+ +DG+ LYQ + FIA G+ L++ Q++ +V+T ++ S
Sbjct: 293 PTEHRCRSPVSWCRPVN-LFYLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVVTLMVTS 351
Query: 350 IGTAGVPGAGAIMLAMVLESVGL 372
G AGVPG ++L L SVG+
Sbjct: 352 KGIAGVPGVSFVVLLATLGSVGI 374
>gb|AAA23832.1| (M32488) glutamate and aspartate carrier (gltP) [Escherichia coli]
Length = 395
Score = 202 bits (508), Expect = 7e-51
Identities = 121/383 (31%), Positives = 217/383 (56%), Gaps = 26/383 (6%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADA----VKTYIKPFGDLFVRLLKMLVMPI 61
K + F + +IL ++LG ++G L HY ++D+ V + P GD+F+ L+KM+V+PI
Sbjct: 2 KNINFSLAWQILFAMVLGILLGSYL-HY-HSDSRDWLVVNLLSPAGDIFIHLIKMIVVPI 59
Query: 62 VFASLVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG- 119
V ++LVVG A + A+ LGR+G K ++Y+ + + A+ LG + +F PGAG+ +++
Sbjct: 60 VISTLVVGIAGVGDAKQLGRIGAKTIIYFEVITTVAIILGSLWRTVFQPGAGVDMSQLAT 119
Query: 120 ---KQFQP------KQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMN 170
++Q + ++ T+L+++PTN ++A G++LP IFF+++ G+ ++ L
Sbjct: 120 VDISKYQSTTEAVQSSSHGIMGTILSLVPTNIVASMAKGEMLPIIFFSVLFGLGLSSLPA 179
Query: 171 SKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAK 230
+ E L+ ++E M+K+ VM+YAP+GVFALIA +A+ G + LAK
Sbjct: 180 TH-------REPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFSSLWPLAK 232
Query: 231 VTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAE 290
+ + V+ + L+V ++ ++ G+ I KD ++ A+ T SS +P MR +
Sbjct: 233 LVLLVHFAILFFALVVLGIVARLCGLSVWILIRILKDELILAYSTASSESVVPRHMRRWK 292
Query: 291 DM-GISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLAS 349
+ S+ P+ +DG+ LYQ + FIA G+ L++ Q++ +V+T ++ S
Sbjct: 293 PTEHRCRSPVSWCRPVN-LFYLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVVTLMVTS 351
Query: 350 IGTAGVPGAGAIMLAMVLESVGL 372
G AGVPG ++L L SVG+
Sbjct: 352 KGIAGVPGVSFVVLLATLGSVGI 374
>sp|Q22682|EAT4_CAEEL PUTATIVE SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER T22E5.2
>gi|7447031|pir||T16921 hypothetical protein T22E5.2 -
Caenorhabditis elegans >gi|1125827|gb|AAA83614.1|
(U43282) Similar to sodium-dependent glutamate/aspartate
transporter [Caenorhabditis elegans]
Length = 502
Score = 201 bits (507), Expect = 9e-51
Identities = 140/461 (30%), Positives = 231/461 (49%), Gaps = 79/461 (17%)
Query: 16 ILIGLILGAIVGLILGHYGYADAVK-------TYIKPFGDLFVRLLKMLVMPIVFASLVV 68
+L+ +LG +VG+ LG + D K +Y++ GDLFV++LKML++P++ +S++
Sbjct: 34 LLLFTVLGVVVGIGLG-FSLRDPSKAWSKRHLSYLRFPGDLFVQMLKMLILPMIMSSIIT 92
Query: 69 GAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAP 128
AS+ GR+G+ ++YY LT+ FAV LGI++ + PG T K P
Sbjct: 93 SLASLDSGTAGRLGMVSMIYYTLTTFFAVFLGIVLVSVIKPGKWTTTNIEDLVGHVKTTP 152
Query: 129 PL---VQTLLNII----PTN---------------------------------------- 141
+ V T+++++ P N
Sbjct: 153 CVATAVDTIIDLMKSCFPENLIEATFRSQKICLKFFNGTTEIPPEIAMTMSPEQRAQFTE 212
Query: 142 -PFGALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVA 199
P +++G +L + F++ LGI I + + + + N L K++
Sbjct: 213 VPEKIVSDGMNILGLVVFSVALGIVIGV--------IGEDGKPMKNFFKSLEACSMKLIG 264
Query: 200 GVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVLLKVFGI--- 256
V+ Y+P+G+ LIA + G+K G+ + + + L +L+ FV++ + +
Sbjct: 265 WVIIYSPVGITFLIAAQIV--GMKDPGQELHRLMGYVITVILGLLIHAFVVIPLLCVVLA 322
Query: 257 --DPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDG 313
+PIKF+ A+LTA T SSS TLP++++ E+ + + F LPLGATINMDG
Sbjct: 323 RRNPIKFVGGMAQALLTALATSSSSATLPLSIKCCEENNKVDPRVTRFVLPLGATINMDG 382
Query: 314 TALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLP 373
TALY+ V +I+ G L+LG+ + + LTA LASIG AG+P AG + + MVL ++GLP
Sbjct: 383 TALYEAVAAIYISQCYGNDLSLGEVVLVSLTATLASIGAAGIPQAGIVTMIMVLIAIGLP 442
Query: 374 LTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
+ +I +D +LD RT VNV GD TA++ +
Sbjct: 443 TN------LFILIFPVDFMLDRLRTTVNVHGDSIATAVIER 477
>gb|AAB71737.1| (U75372) glutamate transporter [Mus musculus]
Length = 572
Score = 201 bits (507), Expect = 9e-51
Identities = 154/465 (33%), Positives = 229/465 (49%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP ++ +N P
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEE 224
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 225 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 276
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 277 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 336
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 337 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 393
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 394 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 453
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 454 IAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 492
>pir||JC4262 glutamate transporter 2 - mouse >gi|882343|gb|AAA91643.1| (U24699)
high affinity glutamate trasporter [Mus musculus]
Length = 574
Score = 201 bits (507), Expect = 9e-51
Identities = 153/465 (32%), Positives = 229/465 (48%), Gaps = 82/465 (17%)
Query: 12 VLQKILIGLILGAIVGLILGHYG--YADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G +L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLSLTVFGVILGAVCGRLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 105 LSGLDAKVSGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 122 --------------------FQPKQ--------APP------------LVQTLLNIIPTN 141
FQ Q APP ++ +N P
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEE 224
Query: 142 PFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAM 194
+ G VL I F I GIA+ ++ + A+ ++ N L E +
Sbjct: 225 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIV 276
Query: 195 YKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYF 248
K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+YF
Sbjct: 277 MKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYF 336
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
V+ + +P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GA
Sbjct: 337 VVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGA 393
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
TINMDGTALY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L
Sbjct: 394 TINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLIL 453
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 454 TAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 492
>gi|10835252 solute carrier family 1 (glutamate transporter), member 7;
excitatory amino acid transporter 5 (retinal glutamate
transporter) [Homo sapiens]
>gi|3023686|sp|O00341|EAT5_HUMAN EXCITATORY AMINO ACID
TRANSPORTER 5 (RETINAL GLUTAMATE TRANSPORTER)
>gi|2076762|gb|AAB53971.1| (U76362) retinal glutamate
transporter EAAT5 [Homo sapiens]
Length = 560
Score = 200 bits (504), Expect = 2e-50
Identities = 157/473 (33%), Positives = 224/473 (47%), Gaps = 92/473 (19%)
Query: 16 ILIGLILGAIVGLILGHYGYADAVK----TYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
+LI +L IVG +LG + + +Y + G+L +R+LKM+++P+VF+SL+ G A
Sbjct: 19 LLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRMLKMMILPLVFSSLMSGLA 78
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI---TLAEAGKQFQ----- 123
S+ R+GV V YYL T+ AV +GI M I +PG+ T ++GK
Sbjct: 79 SLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADA 138
Query: 124 -----------------------------------PKQAPPL--------------VQTL 134
P++APP VQ
Sbjct: 139 LLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPRRILIYGVQEENGSHVQNF 198
Query: 135 L-------NIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAI 187
++ + G VL +FF+ +GI + R+ S L++
Sbjct: 199 ALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLG--------RMGDSGGPLVSFC 250
Query: 188 NGLAEAMYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVGE-LAKVTVAVYVGLALQIL- 244
L E++ KIVA + Y P G+ LIA ++ + VG+ L +V V GL L L
Sbjct: 251 QCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLF 310
Query: 245 ---LVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYS 300
L+YF + K +PI FI A+L A T SSS TLP+T + + E+ I + I
Sbjct: 311 ILPLLYFFITKK---NPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIAR 367
Query: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
F LP+GATINMDGTALY+ V FIA L GQ +TI +T ASIG AG+P AG
Sbjct: 368 FVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITGTAASIGAAGIPQAGL 427
Query: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVA 413
+ + +VL SVGLP D +I+G+D LD RTM+NV GD I+A
Sbjct: 428 VTMVIVLTSVGLPTDD------ITLIIGVDWALDRFRTMINVLGDALAAGIMA 474
>prf||2206275A neuronal Glu transporter EAAC1 [Rattus norvegicus]
Length = 513
Score = 200 bits (504), Expect = 2e-50
Identities = 149/457 (32%), Positives = 231/457 (49%), Gaps = 76/457 (16%)
Query: 12 VLQKILIGLILGAIVG-LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
+L + ++LG +VG L+ GH ++ K + P G++ +R+LK++++P++ +S++ G
Sbjct: 20 LLLSTVAAVVLGIVVGVLVRGHSELSNLDKYFAFP-GEILMRMLKLVILPLIISSMITGV 78
Query: 71 ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK---------- 120
A++ G++G++ VVYY T+ AV LGI++ PG + E +
Sbjct: 79 AALDSNVSGKIGLRAVVYYF-TTVIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTV 137
Query: 121 --------------------QFQPK-------------QAPPLVQTLLNIIPTNP----- 142
Q++ K Q V T + + N
Sbjct: 138 DAMLDLIRNMPENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEKI 197
Query: 143 FGALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGV 201
G ++G VL I F +V G+ I ++ + + L++ N L++A K+ +
Sbjct: 198 VGLYSDGINVLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKVQI-I 248
Query: 202 MQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL---LVYFVLLKVFGID 257
M Y PIG+ LIA ++ + ++ +L V GLA+ L L+YF++++ +
Sbjct: 249 MCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVLPLIYFIVVRK---N 305
Query: 258 PIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGATINMDGTALY 317
P +F A+LTA + SSS TLPVT R AE+ K I F LP+GATINMDGTALY
Sbjct: 306 PFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHDKRITRFVLPVGATINMDGTALY 365
Query: 318 QGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDA 377
+ V FIA GM L++GQ +TI + A ASIG AGVP AG + + +VL VGLP D
Sbjct: 366 EAVAAVFIAQLNGMDLSIGQIITISI-ATAASIGAAGVPQAGLVTMVIVLSPVGLPAEDV 424
Query: 378 NVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
+I+ +D +LD RTM NV GD GT IV K
Sbjct: 425 ------TLIIAVDWLLDRFRTM-NVLGDAFGTGIVEK 454
>gb|AAF14542.2|AF167076_1 (AF167076) glutamate transporter [Canis familiaris]
Length = 564
Score = 200 bits (504), Expect = 2e-50
Identities = 148/466 (31%), Positives = 228/466 (48%), Gaps = 83/466 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 37 LLTLTVFGVILGAVCGGLLRLASPLHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 95
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQFQPKQ 126
+ + GR+G + +VYY+ T+ A LG+I+ NP L K +
Sbjct: 96 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 155
Query: 127 APPLVQTLLNIIP------------------------------TNPFGALANG------- 149
+ + N+ P TN +L N
Sbjct: 156 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSDEDSNATNAVISLLNETVTEAPE 215
Query: 150 ----------------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEA 193
VL I F I GIA+ ++ + A+ ++ N L E
Sbjct: 216 EVKVVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEI 267
Query: 194 MYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVY 247
+ K+V +M Y+P+G+ LI ++A + ++VV +L + V VGL + + L+Y
Sbjct: 268 VMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIY 327
Query: 248 FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLG 306
F++ + +P F + A +TA T SS+GTLPVT R + E++GI K + F LP+G
Sbjct: 328 FLVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVG 384
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
ATINMDGTALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++
Sbjct: 385 ATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASVGAASIPSAGLVTMLLI 444
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
L +VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 445 LTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 484
>emb|CAB72412.1| (AL138978) putative sodium:dicarboxylate symporter [Streptomyces
coelicolor A3(2)]
Length = 466
Score = 200 bits (504), Expect = 2e-50
Identities = 126/410 (30%), Positives = 210/410 (50%), Gaps = 25/410 (6%)
Query: 16 ILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASI-S 74
++I + LG VGL + T +KP G FV L+KM++ PI+F ++V+G S+
Sbjct: 26 VIIAVALGIAVGLAAPDFA------TELKPLGTGFVNLIKMMISPIIFCTIVLGIGSVRK 79
Query: 75 PARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQ----APPL 130
A++G VG + Y+L+ S A+ +G+I+ I +PG G+ + +A K+ Q A
Sbjct: 80 AAKVGAVGGIALGYFLVMSLVALAIGLIVGNILDPGTGLAVTDAVKETGQAQVDAEAKGT 139
Query: 131 VQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGL 190
V L+ IIPT A G+VL T+ A++ G A+ + N+ + +L I +
Sbjct: 140 VDFLMGIIPTTIVSAFTAGEVLQTLLIALLCGFALQAMGNA--------GQPVLRGIEHI 191
Query: 191 AEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVL 250
+++++A +M AP+G F IA V S GV + LA + + Y + + +V +
Sbjct: 192 QRLVFRVLAMIMWAAPVGAFGAIAAVTGSAGVDALKSLAVLMLGFYATCVIFLFVVLGTV 251
Query: 251 LKVF-GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGATI 309
L+V GI+ L T SS LP + E +GISK + T+P G +
Sbjct: 252 LRVVAGINVFSLFKYLGREFLLILSTSSSESALPRLIAKMEHLGISKPVVGITVPTGYSF 311
Query: 310 NMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLES 369
N+DGT +Y + + FI++A+G +++G+Q+ ++L ++AS G AGV GAG LA L+S
Sbjct: 312 NLDGTMIYMTMASLFISDAMGTPMSIGEQIPLLLFLLVASKGAAGVSGAGLATLAGGLQS 371
Query: 370 VGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
L D +I+GID + R + N G+ T ++ E+
Sbjct: 372 HKPALVD-----GIGLIVGIDRFMSEARALTNFGGNAVATVLIGTWTKEI 416
>sp|P43004|EAT2_HUMAN EXCITATORY AMINO ACID TRANSPORTER 2 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER 2)
>gi|3184391|dbj|BAA28706.1| (D85884) glutamate
transporter [Homo sapiens]
Length = 574
Score = 200 bits (503), Expect = 3e-50
Identities = 155/466 (33%), Positives = 232/466 (49%), Gaps = 83/466 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 122 --------------------FQPKQ--------APP---------LVQTLLNI----IPT 140
FQ Q APP V +LLN +P
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPE 224
Query: 141 NPFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEA 193
+ G VL I F I GIA+ ++ A+ +++ N L E
Sbjct: 225 ETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEI 276
Query: 194 MYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVY 247
+ K+V +M Y+P+G+ LI ++A + ++VV +L V V +GL + + L+Y
Sbjct: 277 VMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIY 336
Query: 248 FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLG 306
FV+ + +P F + A +TA T SS+GTLPVT R + E++GI K + F LP+G
Sbjct: 337 FVVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVG 393
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
ATINMDGTALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++
Sbjct: 394 ATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLI 453
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
L +VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 454 LTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 493
>emb|CAC10342.1| (AL133330) dJ68D18.1.2 (solute carrier family 1 (glial high
affinity glutamate transporter) member 2) [Homo sapiens]
Length = 608
Score = 200 bits (503), Expect = 3e-50
Identities = 155/466 (33%), Positives = 232/466 (49%), Gaps = 83/466 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 80 LLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 138
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 139 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 198
Query: 122 --------------------FQPKQ--------APP---------LVQTLLNI----IPT 140
FQ Q APP V +LLN +P
Sbjct: 199 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPE 258
Query: 141 NPFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEA 193
+ G VL I F I GIA+ ++ A+ +++ N L E
Sbjct: 259 ETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEI 310
Query: 194 MYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVY 247
+ K+V +M Y+P+G+ LI ++A + ++VV +L V V +GL + + L+Y
Sbjct: 311 VMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIY 370
Query: 248 FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLG 306
FV+ + +P F + A +TA T SS+GTLPVT R + E++GI K + F LP+G
Sbjct: 371 FVVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVG 427
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
ATINMDGTALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++
Sbjct: 428 ATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLI 487
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
L +VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 488 LTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 527
>emb|CAC10343.1| (AL133330) dJ68D18.1.1 (solute carrier family 1 (glial high
affinity glutamate transporter) member 2) [Homo sapiens]
Length = 568
Score = 200 bits (503), Expect = 3e-50
Identities = 155/466 (33%), Positives = 232/466 (49%), Gaps = 83/466 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 40 LLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 98
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 99 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 158
Query: 122 --------------------FQPKQ--------APP---------LVQTLLNI----IPT 140
FQ Q APP V +LLN +P
Sbjct: 159 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPE 218
Query: 141 NPFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEA 193
+ G VL I F I GIA+ ++ A+ +++ N L E
Sbjct: 219 ETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEI 270
Query: 194 MYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVY 247
+ K+V +M Y+P+G+ LI ++A + ++VV +L V V +GL + + L+Y
Sbjct: 271 VMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIY 330
Query: 248 FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLG 306
FV+ + +P F + A +TA T SS+GTLPVT R + E++GI K + F LP+G
Sbjct: 331 FVVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVG 387
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
ATINMDGTALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++
Sbjct: 388 ATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLI 447
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
L +VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 448 LTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 487
>gi|11435951 solute carrier family 1 (glial high affinity glutamate
transporter), member 2 [Homo sapiens]
Length = 565
Score = 200 bits (503), Expect = 3e-50
Identities = 155/466 (33%), Positives = 232/466 (49%), Gaps = 83/466 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 37 LLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 95
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 96 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 155
Query: 122 --------------------FQPKQ--------APP---------LVQTLLNI----IPT 140
FQ Q APP V +LLN +P
Sbjct: 156 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPE 215
Query: 141 NPFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEA 193
+ G VL I F I GIA+ ++ A+ +++ N L E
Sbjct: 216 ETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEI 267
Query: 194 MYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVY 247
+ K+V +M Y+P+G+ LI ++A + ++VV +L V V +GL + + L+Y
Sbjct: 268 VMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIY 327
Query: 248 FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLG 306
FV+ + +P F + A +TA T SS+GTLPVT R + E++GI K + F LP+G
Sbjct: 328 FVVTRK---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVG 384
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
ATINMDGTALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++
Sbjct: 385 ATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLI 444
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
L +VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 445 LTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 484
>gi|6678003 solute carrier family 1, member 6 [Mus musculus]
>gi|3023688|sp|O35544|EAT4_MOUSE EXCITATORY AMINO ACID
TRANSPORTER 4 (SODIUM-DEPENDENT GLUTAMATE/ASPARTATE
TRANSPORTER) (HIGH-AFFINITY NEURONAL GLUTAMATE
TRANSPORTER) >gi|2648172|dbj|BAA23640.1| (D83262)
neuronal glutamate transporter EAAT4 [Mus musculus]
Length = 561
Score = 199 bits (501), Expect = 5e-50
Identities = 152/477 (31%), Positives = 226/477 (46%), Gaps = 86/477 (18%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G + L Y + Y G+L +R+L+MLV+P++ +SLV G AS+ G
Sbjct: 63 VIIGVSLAFALRPYQLSYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATG 122
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGIT--LAEAGKQFQPKQAPPLVQTLLNI 137
R+G++ VYY++T+ AV +GI+M I +PG G L G+ A + + N+
Sbjct: 123 RMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVRNM 182
Query: 138 IPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKD------------------ERVRKS 179
P N A K T + V+ I N + E V ++
Sbjct: 183 FPPNLVEACF--KQFKTQYSTRVVTRTIVRTDNGSELGASMSPTSSVENETSILENVTRA 240
Query: 180 AETL---------------LNAINGLAEAMYKIVAG------------------------ 200
TL N IN L ++ + G
Sbjct: 241 LGTLQEVISFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAI 300
Query: 201 ------VMQYAPIGVFALIA-NVMASQGVKVV-GELAKVTVAVYVGLALQ----ILLVYF 248
++ YAP+G+ LIA ++ + + V+ G+L T+ V VGL L + L+YF
Sbjct: 301 MRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYF 360
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
+ V +P FI A++TA T SSS TLP+T R E+ +G+ + I F LP+GA
Sbjct: 361 L---VTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA 417
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
T+NMDGTALY+ + FIA L LGQ TI +TA AS+G AG+P AG + + +VL
Sbjct: 418 TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL 477
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV---AKTEGELKE 421
SVGLP D +I+ +D LD RTM NV GD G A++ ++ E EL+E
Sbjct: 478 TSVGLPTED------ITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQE 528
>emb|CAA10803.1| (AJ132846) sodium-dependent neutral amino acid transporter, ASCT2
[Rattus norvegicus]
Length = 539
Score = 199 bits (500), Expect = 6e-50
Identities = 136/432 (31%), Positives = 225/432 (51%), Gaps = 55/432 (12%)
Query: 21 ILGAIVGLILGHYGYADAVK----TYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPA 76
+ G ++GL + G A+A+ T G+L +RLL+M+++P+V SL+ GAAS+ P+
Sbjct: 64 VAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLEMIILPLVVCSLIGGAASLDPS 123
Query: 77 RLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPP------- 129
LGR+G ++++L+T+ + LG+ +A PGA + P
Sbjct: 124 ALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAFAAINSSVVDSSVHRAPTKEVLDS 183
Query: 130 LVQTLLNIIPTN----------PFGALANGK--------------VLPTIFFAIVLGIAI 165
++ L N+ P+N P GA +L + FAIV G+A+
Sbjct: 184 FLELLRNMFPSNLVSASAAFRIPCGACPQRSNATMDQPHCEMKMNILGLVVFAIVFGVAL 243
Query: 166 TYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIAN-VMASQGVK- 223
++ E L+ N +A +V+ +M YAPIG+ L+A ++ + ++
Sbjct: 244 --------RKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPIGILFLVAGKIVEMKDIRQ 295
Query: 224 -VVGELAKVTVAVYVGLALQILLVYFVLLKVFGI-DPIKFISKAKDAMLTAFVTRSSSGT 281
+G L K V +G A+ LLV ++ +F +P +F+ + TAF T SSS T
Sbjct: 296 LFIG-LGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSAT 354
Query: 282 LPVTMRVAEDM-GISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLT 340
LP+ M+ E+ G++K I F LP+GAT+NMDG AL+Q V FIA GM L + +T
Sbjct: 355 LPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGMSLDFVKIIT 414
Query: 341 IVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMV 400
I++TA +S+G AG+P G + LA++LE++ LP+ D ++IL +D ++D T++
Sbjct: 415 ILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKD------ISLILAVDWLVDRSCTVL 468
Query: 401 NVTGDLTGTAIV 412
NV GD G ++
Sbjct: 469 NVEGDAFGAGLL 480
>pir||I38399 glutamate/aspartate transporter II - human
>gi|498251|gb|AAA18900.1| (U01824) glutamate/aspartate
transporter II [Homo sapiens]
Length = 565
Score = 198 bits (499), Expect = 8e-50
Identities = 153/461 (33%), Positives = 230/461 (49%), Gaps = 83/461 (18%)
Query: 17 LIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASIS 74
+ G+ILG++ G L L + D V P GD+ +R+LKML++P++ +SL+ G + +
Sbjct: 42 VFGVILGSVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITGLSGLD 100
Query: 75 PARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ---------- 121
GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 101 AKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFL 160
Query: 122 ---------------FQPKQ--------APP---------LVQTLLNI----IPTNPFGA 145
FQ Q APP V +LLN +P
Sbjct: 161 DLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMV 220
Query: 146 LANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
+ G VL I F I GIA+ ++ A+ +++ N L E + K+V
Sbjct: 221 IKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEIVMKLV 272
Query: 199 AGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYFVLLK 252
+M Y+P+G+ LI ++A + ++VV +L V V +GL + + L+YFV+ +
Sbjct: 273 IMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTR 332
Query: 253 VFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINM 311
+P F + A +TA T SS+GTLPVT R + E++GI K + F LP+GATINM
Sbjct: 333 K---NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINM 389
Query: 312 DGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVG 371
DGTALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++L +VG
Sbjct: 390 DGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVG 449
Query: 372 LPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
LP D ++++ +D +LD RT VNV GD G IV
Sbjct: 450 LPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 484
>gb|AAB88287.1| (AF018257) glutamate transporter 2A [Ambystoma tigrinum]
Length = 579
Score = 198 bits (497), Expect = 1e-49
Identities = 147/468 (31%), Positives = 234/468 (49%), Gaps = 68/468 (14%)
Query: 12 VLQKILIGLILGAIVGLILGHYG--YADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L ++G+I+GA+ G +L + D V P GD+ +R+LKML++P+V +SL+ G
Sbjct: 46 LLTLTVLGVIMGALCGGLLRMASPIHPDIVMVIGFP-GDILMRMLKMLILPLVISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG---KQFQPKQ 126
+ + GR+G + +VYY++T+ A LG+I+ +PG + G K +
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMVTTVIAAILGVILVLAIHPGNPKLREQMGQGQKNDEVSS 164
Query: 127 APPLVQTLLNIIPTNPFGAL------ANGKVL-------PTIFFAIVLGIAITYLMNSKD 173
+ + N+ P N A KV+ P+ +L + T L + +
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVVVQPPPEEPSNITESLLALVNTTLNETTE 224
Query: 174 E--------------------------------RVRKSAETLLNAINGLAEAMYKIVAGV 201
E ++ + A +++ N L E + K+V +
Sbjct: 225 EVKVILKKGLEFKDGMNVLGLIGFFIAFGISMGKMGEQARLMVDFFNILNEIVMKLVTMI 284
Query: 202 MQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGL----ALQILLVYFVLLKVFG 255
M Y+P+G+ LI ++A +++V +L V V VGL A+ + L+YF + +
Sbjct: 285 MWYSPLGIACLICGKIIAIADLELVARQLGMYMVTVIVGLIIHGAIFLPLIYFAITRK-- 342
Query: 256 IDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGT 314
+P F A +TA T SS+GTLPVT R + E++ I K + F LP+GATINMDGT
Sbjct: 343 -NPFTFFVGIFQAWITALGTASSAGTLPVTFRCLEENLHIDKRVTRFVLPVGATINMDGT 401
Query: 315 ALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPL 374
ALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++L +VGLP
Sbjct: 402 ALYEAVAAIFIAQMNGIVLDGGQIITVSLTATLASVGAASIPSAGLVTMLLILTAVGLPT 461
Query: 375 TDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK-TEGELKE 421
D ++++ +D LD RT VNV GD G IV + EL+E
Sbjct: 462 QD------ISLLVAVDWFLDRMRTSVNVVGDSFGAGIVYHLSRAELEE 503
>gi|4759124 solute carrier family 1 (glial high affinity glutamate
transporter), member 2; Solute carrier family 1 (glial
high affinity glutamate transporter),; H.sapiens mRNA
for glutamate transporter [Homo sapiens]
>gi|2135091|pir||I38432 excitatory amino acid
transporter2 - human >gi|487341|gb|AAA50429.1| (U03505)
excitatory amino acid transporter2 [Homo sapiens]
>gi|746199|prf||2017269B excitatory AA
transporter:ISOTYPE=2 [Homo sapiens]
Length = 574
Score = 197 bits (496), Expect = 2e-49
Identities = 151/466 (32%), Positives = 229/466 (48%), Gaps = 83/466 (17%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF---NPGAGITLAEAGKQ----- 121
+ + GR+G + +VYY+ T+ A LG+I+ NP L K
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 122 --------------------FQPKQ--------APP-------------LVQTLLNIIPT 140
FQ Q APP L+ + +P
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAEVSLLNETVTEVPE 224
Query: 141 NPFGALANG-------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEA 193
+ G VL I F I GIA+ ++ A+ +++ N L E
Sbjct: 225 ETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEI 276
Query: 194 MYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVY 247
+ K+V +M Y+P+G+ LI ++A + ++VV +L V V +GL + + L+Y
Sbjct: 277 VMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIY 336
Query: 248 FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLG 306
FV+ + +P + A +TA T SS+GTLPVT R + E++GI K + F LP+G
Sbjct: 337 FVVTRK---NPFSLFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVG 393
Query: 307 ATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMV 366
ATINMDGTALY+ V FIA G+ L GQ +T+ LTA LAS+G A +P AG + + ++
Sbjct: 394 ATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLI 453
Query: 367 LESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
L +VGLP D ++++ +D +LD RT VNV GD G IV
Sbjct: 454 LTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 493
>sp|Q15758|AAAT_HUMAN NEUTRAL AMINO ACID TRANSPORTER B(0) (ATB(0))
>gi|1478281|gb|AAC50629.1| (U53347) neutral amino acid
transporter B [Homo sapiens]
Length = 541
Score = 197 bits (496), Expect = 2e-49
Identities = 138/439 (31%), Positives = 226/439 (51%), Gaps = 58/439 (13%)
Query: 17 LIGLILGAIVGLILGHYGYA-----DAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
++ ++ G +GL + G A A++ ++ P G+L +RLL+M+++P+V SL+ GAA
Sbjct: 59 VVAVVAGVALGLGVSGAGGALALGPGALEAFVFP-GELLLRLLRMIILPLVVCSLIGGAA 117
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL--AEAGKQFQPKQAPP 129
S+ P LGR+G ++++L+T+ A LG+ +A PGA A G + AP
Sbjct: 118 SLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPS 177
Query: 130 ------LVQTLLNIIPTN-------------------------PFGALANG-KVLPTIFF 157
+ NI P+N P G G +L + F
Sbjct: 178 KEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVF 237
Query: 158 AIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIAN-V 216
AIV G+A+ ++ E L+ N EA +V+ +M YAP+G+ L+A +
Sbjct: 238 AIVFGVAL--------RKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKI 289
Query: 217 MASQGVKVV-GELAKVTVAVYVGLALQILLVYFVLLKVFGI-DPIKFISKAKDAMLTAFV 274
+ + V ++ L K + +G A+ LLV ++ +F +P +F+ + TAF
Sbjct: 290 VEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFG 349
Query: 275 TRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHL 333
T SSS TLP+ M+ V E+ G++K I F LP+GAT+NMDG AL+Q V FIA L
Sbjct: 350 TSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSL 409
Query: 334 TLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAIL 393
+ +TI++TA +S+G AG+P G + LA++LE+V LP+ ++IL +D ++
Sbjct: 410 DFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDH------ISLILAVDWLV 463
Query: 394 DMGRTMVNVTGDLTGTAIV 412
D T++NV GD G ++
Sbjct: 464 DRSCTVLNVEGDALGAGLL 482
>gi|4827012 solute carrier family 1 (high affinity aspartate/glutamate
transporter), member 6; excitatory amino acid
transporter 4 [Homo sapiens]
>gi|11426759|ref|XP_009353.1| solute carrier family 1
(high affinity aspartate/glutamate transporter), member
6 [Homo sapiens] >gi|1352333|sp|P48664|EAT4_HUMAN
EXCITATORY AMINO ACID TRANSPORTER 4 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER) >gi|7447030|pir||S58398
excitatory amino acid transporter 4 - human
>gi|930337|gb|AAA75314.1| (U18244) excitatory amino acid
transporter 4 [Homo sapiens] >gi|3108022|gb|AAC15754.1|
(AC004659) EAT4_HUMAN [Homo sapiens]
>gi|1097862|prf||2114371A Asp/Glu transporter [Homo
sapiens]
Length = 564
Score = 197 bits (496), Expect = 2e-49
Identities = 150/477 (31%), Positives = 225/477 (46%), Gaps = 86/477 (18%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+++G + L Y Y G+L +R+L+MLV+P++ +SLV G AS+ G
Sbjct: 66 VVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATG 125
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGIT--LAEAGKQFQPKQAPPLVQTLLNI 137
R+G++ VYY++T+ AV +GI+M I +PG G L G+ A + + N+
Sbjct: 126 RMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMDLIRNM 185
Query: 138 IPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKD------------------ERVRKS 179
P N A K T + V+ + N + E V ++
Sbjct: 186 FPPNLVEACF--KQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENVTRA 243
Query: 180 AETL---------------LNAINGLAEAMYKIVAG------------------------ 200
TL N IN L ++ + G
Sbjct: 244 LGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAI 303
Query: 201 ------VMQYAPIGVFALIA-NVMASQGVKVV-GELAKVTVAVYVGLALQ----ILLVYF 248
++ YAP+G+ LIA ++ + + V+ G+L T+ V VGL L + L+YF
Sbjct: 304 MRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYF 363
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
+ V +P FI A++TA T SSS TLP+T R E+ +G+ + I F LP+GA
Sbjct: 364 L---VTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA 420
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
T+NMDGTALY+ + FIA L LGQ TI +TA AS+G AG+P AG + + +VL
Sbjct: 421 TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL 480
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV---AKTEGELKE 421
SVGLP D +I+ +D LD RTM NV GD G A++ ++ E EL+E
Sbjct: 481 TSVGLPTED------ITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQE 531
>pir||E82740 C4-dicarboxylate transport protein XF0976 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9105906|gb|AAF83786.1|AE003935_12 (AE003935)
C4-dicarboxylate transport protein [Xylella fastidiosa]
Length = 490
Score = 196 bits (494), Expect = 3e-49
Identities = 126/418 (30%), Positives = 204/418 (48%), Gaps = 25/418 (5%)
Query: 11 PVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
P ++ +I+ I+G +LGH V +KP GD F++L+KM++ P++F ++V G
Sbjct: 59 PFYLQLYFWVIIAIILGALLGHC--YPVVGQQLKPLGDAFIKLVKMIISPVIFLTIVTGI 116
Query: 71 ASISPA-RLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL-------AEAGKQF 122
AS++ + RV K +VY+L S A+ LG+++A + +PG G+ + E
Sbjct: 117 ASVAHVGTVARVFGKAMVYFLFFSTLALLLGLVVAHVVHPGVGMNINPADLHQGEIASYV 176
Query: 123 QPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAET 182
+ LV L++IIP +L +F A++ GIA+ + +
Sbjct: 177 EKSHDLTLVGFLMDIIPKTLLSPFVGDNILQVLFVAVLFGIALAL--------AGERGKP 228
Query: 183 LLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQ 242
+LN ++ L ++K+V +M+ APIG F IA + GV + L + + Y+ L
Sbjct: 229 VLNLLDALTLPVFKLVQMLMKMAPIGAFGAIAFTIGKYGVDSLVNLGWLVGSFYLTSLLF 288
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFT 302
+L++ + G +K I K +L T SS LP M G K +
Sbjct: 289 VLVILGAVSWFSGFSILKLIRYLKSELLLVLGTSSSEAALPSLMEKMVQAGCKKSVVGLV 348
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
+P G + N+DGT +Y + FIA A LT QL + L A+L+S G AGV GAG I
Sbjct: 349 VPTGYSFNLDGTNIYMTLAALFIAQATNTELTPAHQLALFLVAMLSSKGAAGVSGAGFIT 408
Query: 363 LAMVLESV-GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
LA L V +P+ A A+ILG+D + R++ N G+ T +V++ E L
Sbjct: 409 LAATLTVVPEVPI------AGMALILGVDRFMSECRSLTNFIGNAVATLVVSRWENAL 460
>sp|O35921|EAT4_RAT EXCITATORY AMINO ACID TRANSPORTER 4 (SODIUM-DEPENDENT
GLUTAMATE/ASPARTATE TRANSPORTER) (HIGH-AFFINITY NEURONAL
GLUTAMATE TRANSPORTER) >gi|2465213|gb|AAB72086.1|
(U89608) EAAT4 [Rattus norvegicus]
Length = 561
Score = 196 bits (494), Expect = 3e-49
Identities = 151/477 (31%), Positives = 224/477 (46%), Gaps = 86/477 (18%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+I+G + L Y Y G+L +R+L+MLV+P++ +S V G AS+ G
Sbjct: 63 VIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSRVTGMASLDNKATG 122
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGIT--LAEAGKQFQPKQAPPLVQTLLNI 137
R+G++ VYY++T+ AV +GI+M I +PG G L G+ A + + N+
Sbjct: 123 RMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVRNM 182
Query: 138 IPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKD------------------ERVRKS 179
P N A K T + V+ I N + E V ++
Sbjct: 183 FPPNLVEACF--KQFKTQYSTRVVTRTIVRTDNGSELGASISPPSSAENETSILENVTRA 240
Query: 180 AETL---------------LNAINGLAEAMYKIVAG------------------------ 200
TL N IN L ++ + G
Sbjct: 241 LGTLQEVISFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAI 300
Query: 201 ------VMQYAPIGVFALIA-NVMASQGVKVV-GELAKVTVAVYVGLALQ----ILLVYF 248
++ YAP+G+ LIA ++ + + V+ G+L T+ V VGL L + L+YF
Sbjct: 301 MRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYF 360
Query: 249 VLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGA 307
+ V +P FI A++TA T SSS TLP+T R E+ +G+ + I F LP+GA
Sbjct: 361 L---VTHRNPFPFIGGILQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA 417
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
T+NMDGTALY+ + FIA L LGQ TI +TA AS+G AG+P AG + + +VL
Sbjct: 418 TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL 477
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV---AKTEGELKE 421
SVGLP D +I+ +D LD RTM NV GD G A++ ++ E EL+E
Sbjct: 478 TSVGLPTED------ITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQE 528
>gb|AAB88290.1| (AF018260) glutamate transporter 5B [Ambystoma tigrinum]
Length = 544
Score = 196 bits (493), Expect = 4e-49
Identities = 151/479 (31%), Positives = 226/479 (46%), Gaps = 83/479 (17%)
Query: 3 WLKKYLEFPVLQKI-LIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPI 61
WL+ Y + L + ++ +I G ++G +L +D K Y G+L +R+LKML++P+
Sbjct: 23 WLRNYWKKNGLLTLSMLSVITGCLIGFLLRALELSDQEKQYFSFPGELLMRMLKMLILPL 82
Query: 62 VFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI-------- 113
+ +SL+ G A++ G++G+ + YYL T+ AV +GII+ +PGA
Sbjct: 83 ITSSLMSGLATMDSKVCGKMGLITITYYLWTTFLAVAVGIILVICIHPGAAAQKEEHLGG 142
Query: 114 --------------------TLAEAGKQ--------------------------FQPKQA 127
L EA Q F P
Sbjct: 143 KPILSSADALLDLIRNMFPANLIEASFQQYRTVLIPVVKSQDTKFLKKSLSFIYFAPDDK 202
Query: 128 PPLVQ--TLLNIIP-------TNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRK 178
P + LL I P T P G VL + F+ +G+ L+ +R
Sbjct: 203 NPEIHRPVLLEITPSPQMSYKTRP-GTNTEMNVLGIVIFSATIGL----LLGKMGDR--- 254
Query: 179 SAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVGE-LAKVTVAVY 236
L+N L EA+ KIV+ + Y P G+ LIA ++ + +G+ L + V
Sbjct: 255 -GAPLVNVCQCLNEAVMKIVSVAVWYFPFGIVFLIAGKILDMEDPATIGKKLGLYAITVM 313
Query: 237 VGLALQILLVYFVLLKVFGI-DPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGI 294
GL + +++ +L +F +P FI A+L A T SSS TLP+T++ + E+ GI
Sbjct: 314 AGLFIHGVILLPLLYLIFTKKNPFPFIQGILQALLIALATSSSSATLPITLKCLLENNGI 373
Query: 295 SKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAG 354
+ + F LP+GATINMDGTALY+ V FIA L +GQ +TI +TA ASIG AG
Sbjct: 374 DRRVARFVLPVGATINMDGTALYEAVAAIFIAQVNEYDLDMGQIITISITATAASIGAAG 433
Query: 355 VPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVA 413
+P +G + + +VL SVGLP D +I+ +D LD RTM NV GD IVA
Sbjct: 434 IPQSGLVTMVIVLTSVGLPTDD------ITLIVAVDWALDRFRTMTNVLGDALAAGIVA 486
>gb|AAD09814.1| (AF105230) neutral amino acid transporter [Homo sapiens]
Length = 541
Score = 196 bits (493), Expect = 4e-49
Identities = 137/439 (31%), Positives = 225/439 (51%), Gaps = 58/439 (13%)
Query: 17 LIGLILGAIVGLILGHYGYA-----DAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
++ ++ G +GL + G A + + ++ P G+L +RLL+M+++P+V SL+ GAA
Sbjct: 59 VVAVVAGVALGLGVSGAGGALALGPERLSAFVFP-GELLLRLLRMIILPLVVCSLIGGAA 117
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL--AEAGKQFQPKQAPP 129
S+ P LGR+G ++++L+T+ A LG+ +A PGA A G + AP
Sbjct: 118 SLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPS 177
Query: 130 ------LVQTLLNIIPTN-------------------------PFGALANG-KVLPTIFF 157
+ NI P+N P G G +L + F
Sbjct: 178 KEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVF 237
Query: 158 AIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIAN-V 216
AIV G+A+ ++ E L+ N EA +V+ +M YAP+G+ L+A +
Sbjct: 238 AIVFGVAL--------RKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKI 289
Query: 217 MASQGVKVV-GELAKVTVAVYVGLALQILLVYFVLLKVFGI-DPIKFISKAKDAMLTAFV 274
+ + V ++ L K + +G A+ LLV ++ +F +P +F+ + TAF
Sbjct: 290 VEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFG 349
Query: 275 TRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHL 333
T SSS TLP+ M+ V E+ G++K I F LP+GAT+NMDG AL+Q V FIA L
Sbjct: 350 TSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSL 409
Query: 334 TLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAIL 393
+ +TI++TA +S+G AG+P G + LA++LE+V LP+ ++IL +D ++
Sbjct: 410 DFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDH------ISLILAVDWLV 463
Query: 394 DMGRTMVNVTGDLTGTAIV 412
D T++NV GD G ++
Sbjct: 464 DRSCTVLNVEGDALGAGLL 482
>gi|5032093 solute carrier family 1 (neutral amino acid transporter), member 5;
baboon M7 virus receptor; RD114 virus receptor; neutral
amino acid transporter B [Homo sapiens]
>gi|4689195|gb|AAD27806.1|AF105423_1 (AF105423)
sodium-dependent neutral amino acid transporter [Homo
sapiens]
Length = 541
Score = 196 bits (493), Expect = 4e-49
Identities = 137/439 (31%), Positives = 225/439 (51%), Gaps = 58/439 (13%)
Query: 17 LIGLILGAIVGLILGHYGYA-----DAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
++ ++ G +GL + G A + + ++ P G+L +RLL+M+++P+V SL+ GAA
Sbjct: 59 VVAVVAGVALGLGVSGAGGALALGPERLSAFVFP-GELLLRLLRMIILPLVVCSLIGGAA 117
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL--AEAGKQFQPKQAPP 129
S+ P LGR+G ++++L+T+ A LG+ +A PGA A G + AP
Sbjct: 118 SLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPS 177
Query: 130 ------LVQTLLNIIPTN-------------------------PFGALANG-KVLPTIFF 157
+ NI P+N P G G +L + F
Sbjct: 178 KEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVF 237
Query: 158 AIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIAN-V 216
AIV G+A+ ++ E L+ N EA +V+ +M YAP+G+ L+A +
Sbjct: 238 AIVFGVAL--------RKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKI 289
Query: 217 MASQGVKVV-GELAKVTVAVYVGLALQILLVYFVLLKVFGI-DPIKFISKAKDAMLTAFV 274
+ + V ++ L K + +G A+ LLV ++ +F +P +F+ + TAF
Sbjct: 290 VEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFG 349
Query: 275 TRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHL 333
T SSS TLP+ M+ V E+ G++K I F LP+GAT+NMDG AL+Q V FIA L
Sbjct: 350 TSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSL 409
Query: 334 TLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAIL 393
+ +TI++TA +S+G AG+P G + LA++LE+V LP+ ++IL +D ++
Sbjct: 410 DFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDH------ISLILAVDWLV 463
Query: 394 DMGRTMVNVTGDLTGTAIV 412
D T++NV GD G ++
Sbjct: 464 DRSCTVLNVEGDALGAGLL 482
>sp|O19105|AAAT_RABIT NEUTRAL AMINO ACID TRANSPORTER B(0) (ATB(0))
>gi|2315861|gb|AAB66298.1| (U75284) neutral amino acid
transporter B0. [Oryctolagus cuniculus]
Length = 541
Score = 195 bits (491), Expect = 7e-49
Identities = 139/439 (31%), Positives = 226/439 (50%), Gaps = 58/439 (13%)
Query: 17 LIGLILGAIVGLILGHYGYADAVK-----TYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
++ ++ G +GL + G A A+ + P G+L +RLLKM+++P+V SLV GAA
Sbjct: 60 VVAVVAGVALGLAVSGAGGALALGPARLIAFAFP-GELLLRLLKMIILPLVVCSLVGGAA 118
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG-------KQFQP 124
S+ P+ LGR+G ++++L+T+ A LG+ +A PGA A +Q
Sbjct: 119 SLDPSALGRLGAWALLFFLVTTLLASALGVGLALALQPGAAFAAMNASLSSTGAVEQTPS 178
Query: 125 KQA-PPLVQTLLNIIPTNPFGALA------------NG--------------KVLPTIFF 157
KQ + L NI P+N A NG +L + F
Sbjct: 179 KQVLDSFLDLLRNIFPSNLVSAAFRSYSTSYEEKNFNGTLVKVPVAHEEEGMNILGLVVF 238
Query: 158 AIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIAN-V 216
AIV G+A+ ++ E L+ N +A +V+ +M YAP+G+ L+A+ +
Sbjct: 239 AIVFGVAL--------RKLGPEGEPLIRFFNSFNDATMVLVSWIMWYAPVGILFLVASKI 290
Query: 217 MASQGVKVV-GELAKVTVAVYVGLALQILLVYFVLLKVFGI-DPIKFISKAKDAMLTAFV 274
+ V V+ L K + +G A+ LLV ++ +F +P +F+ + AF
Sbjct: 291 VEMDDVGVLFASLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGILTPLAMAFG 350
Query: 275 TRSSSGTLPVTMRVAEDM-GISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHL 333
T SSS TLP+ M+ E+ G++K I F LP+GAT+NMDG AL+Q V FIA L
Sbjct: 351 TSSSSATLPLMMKCVEERNGVAKHISRFVLPIGATVNMDGAALFQCVAAVFIAQLNRQSL 410
Query: 334 TLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAIL 393
+ +TI++TA +S+G AG+P G + LA++LE+V LP+++ ++IL +D ++
Sbjct: 411 DFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVSLPVSE------ISLILAVDWLV 464
Query: 394 DMGRTMVNVTGDLTGTAIV 412
D T++NV GD G ++
Sbjct: 465 DRSCTIINVEGDAFGAGLL 483
>gb|AAG02180.1|AF246130_1 (AF246130) neutral amino acid transporter ASCT2 [Mus musculus]
Length = 555
Score = 193 bits (486), Expect = 3e-48
Identities = 139/448 (31%), Positives = 227/448 (50%), Gaps = 69/448 (15%)
Query: 20 LILGAIVGLILGHYGYADAVK----TYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISP 75
++ G +GL + G ADA+ T G+L +RLLKM+++P+V SL+ GAAS+ P
Sbjct: 63 VVAGVGLGLGVSAAGGADALGPARLTAFAFPGELLLRLLKMIILPLVVCSLIGGAASLDP 122
Query: 76 ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEA--GKQFQP--KQAPP-- 129
+ LGRVG ++++L+T+ A LG+ +A PGA +T + P + AP
Sbjct: 123 SALGRVGAWALLFFLVTTLLASALGVGLALALKPGAAVTAITSINDSVVDPCARSAPTKE 182
Query: 130 ----LVQTLLNIIPTNPFGALANG------------------------------------ 149
+ + NI P+N A
Sbjct: 183 VLDSFLDLVRNIFPSNLVSAAFRSFATSYEPKDNSCKIPQSCIQREINSTMVQLLCEVEG 242
Query: 150 -KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIG 208
+L + FAIV G+A+ ++ E L+ N +A +V+ +M YAP+G
Sbjct: 243 MNILGLVVFAIVFGVAL--------RKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPVG 294
Query: 209 VFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQILLVYFVLLKVFGI-DPIKFISKA 265
+ L+A+ ++ + V+ + L K + +G A+ LLV ++ +F +P +F+
Sbjct: 295 ILFLVASKIVEMKDVRQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGI 354
Query: 266 KDAMLTAFVTRSSSGTLPVTMRVAEDM-GISKGIYSFTLPLGATINMDGTALYQGVCTFF 324
+ TAF T SSS TLP+ M+ E+ G++K I F LP+GAT+NMDG AL+Q V F
Sbjct: 355 MTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVF 414
Query: 325 IANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYA 384
IA G+ L + +TI++TA +S+G AG+P G + LA++LE+V LP+ D +
Sbjct: 415 IAQLNGVSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVSLPVKD------IS 468
Query: 385 MILGIDAILDMGRTMVNVTGDLTGTAIV 412
+IL +D ++D T++NV GD G ++
Sbjct: 469 LILAVDWLVDRSCTVLNVEGDAFGAGLL 496
>gb|AAD09812.1| (AF102826) RD114/simian type D retrovirus receptor [Homo sapiens]
Length = 541
Score = 193 bits (485), Expect = 4e-48
Identities = 136/439 (30%), Positives = 223/439 (49%), Gaps = 58/439 (13%)
Query: 17 LIGLILGAIVGLILGHYGYA-----DAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
++ ++ G +GL + G A + + ++ P G+L +RLL+M+++P+V SL+ GAA
Sbjct: 59 VVAVVAGVALGLGVSGAGGALALGPERLSAFVFP-GELLLRLLRMIILPLVVCSLIGGAA 117
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL--AEAGKQFQPKQAPP 129
S+ P LGR+G ++++L+T+ A LG+ +A PGA A G + AP
Sbjct: 118 SLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPS 177
Query: 130 ------LVQTLLNIIPTN-------------------------PFGALANG-KVLPTIFF 157
+ NI P+N P G G +L + F
Sbjct: 178 KEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVF 237
Query: 158 AIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIAN-V 216
AIV G+A+ ++ E L+ N EA +V+ +M YAP+G+ L+A +
Sbjct: 238 AIVFGVAL--------RKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKI 289
Query: 217 MASQGVKVV-GELAKVTVAVYVGLALQILLVYFVLLKVFGI-DPIKFISKAKDAMLTAFV 274
+ + V ++ L K + +G A+ LLV ++ +F +P +F+ + TAF
Sbjct: 290 VEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFG 349
Query: 275 TRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHL 333
T SSS TLP+ M+ V E+ G++K I F LP+GAT+NMDG AL+Q V FIA L
Sbjct: 350 TSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSL 409
Query: 334 TLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAIL 393
+ +TI++TA +S+G AG+P G + LA++LE+V LP+ ++IL + +
Sbjct: 410 DFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHV------SLILAVGWLA 463
Query: 394 DMGRTMVNVTGDLTGTAIV 412
D T++NV GD G ++
Sbjct: 464 DRSCTVLNVEGDALGAGLL 482
>gb|AAB88288.1| (AF018258) glutamate transporter 2B [Ambystoma tigrinum]
Length = 581
Score = 192 bits (484), Expect = 5e-48
Identities = 146/480 (30%), Positives = 227/480 (46%), Gaps = 89/480 (18%)
Query: 2 GWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPF-GDLFVRLLKMLVMP 60
GWL + L +L + G+ILG++ G +L D+ + F GD+ +R+LKML++P
Sbjct: 33 GWLTRNL---LLILTIGGVILGSVFGTLLRLLPPLDSNIVLLISFPGDILMRMLKMLILP 89
Query: 61 IVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
+V +SL+ G A + GR+G + +VYY+ T+ A LG+I+ +PG +
Sbjct: 90 LVISSLISGLAGLDAKSSGRMGTRAMVYYMSTTILAAVLGVILVLSIHPGNPKLKKQVSI 149
Query: 121 QFQPKQAPPL----------------------VQTLLNIIPTNPF--------------- 143
+ ++ L +QT+ +P P
Sbjct: 150 STKNEEVSSLDAFLDLIRNLFPENLVQACFQQIQTVSKKVPVTPSPHELLNQVNISVSQS 209
Query: 144 ------GALANGKVLPT------------------IFFAIVLGIAITYLMNSKDERVRKS 179
A G PT I F I GIA+ ++ +
Sbjct: 210 NSSMLNSTTAEGNAGPTMVTQKKLEFKAGMNVLGLIGFFIAFGIAM--------GKMGEQ 261
Query: 180 AETLLNAINGLAEAMYKIVAGVMQYAPIGVFALI-ANVMASQGVKVVG-ELAKVTVAVYV 237
A + + N L E + K+V +M Y+P G+ LI + A + ++VV +L V V V
Sbjct: 262 ARLMADFFNILNEIIMKLVNMIMWYSPFGIACLICGKIAAIKDLEVVARQLGMYMVTVIV 321
Query: 238 GLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDM 292
GL + + L++F + + +P F A +TA T SS+GTLPVT R + E++
Sbjct: 322 GLVIHGGIVLPLIFFSITRT---NPYTFYGGIFQAWITALGTASSAGTLPVTFRCLEENL 378
Query: 293 GISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGT 352
I K + F LP+GATINMDGTALY+ V FIA + L GQ T+ LTA LAS+G
Sbjct: 379 KIDKRVTRFVLPIGATINMDGTALYEAVAAIFIAQMNDVSLDGGQIATVSLTATLASVGA 438
Query: 353 AGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
A +P AG + + ++L +VGLP D ++++ +D +LD RT +NV GD G I+
Sbjct: 439 ASIPSAGLVTMLLILTAVGLPTQD------ISLLIAVDWLLDRMRTSINVVGDSFGAGII 492
>gb|AAD09142.1| (AF001784) sodium-dependent glutamate transporter [Drosophila
melanogaster] >gi|4887628|dbj|BAA77814.1| (AB027469)
glutamate transporter DGLT-1 [Drosophila melanogaster]
>gi|5033823|dbj|BAA78032.2| (D86739) glutamate
transporter [Drosophila melanogaster]
>gi|5713154|gb|AAD47829.1|AF165999_1 (AF165999)
sodium-dependent excitatory amino acid transporter 1
[Drosophila melanogaster] >gi|7297508|gb|AAF52764.1|
(AE003624) Eaat1 gene product [Drosophila melanogaster]
Length = 479
Score = 192 bits (484), Expect = 5e-48
Identities = 134/457 (29%), Positives = 225/457 (48%), Gaps = 65/457 (14%)
Query: 2 GWLKKYLEFPVL-QKILIGLILGAIVGLIL----GHYGYADAVKTYIKPFGDLFVRLLKM 56
G K +++ VL +IG+ +G ++G I+ G + + + YI G++F+R+LK
Sbjct: 9 GKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIM--YISFPGEIFLRMLKC 66
Query: 57 LVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLA 116
L++P++ +S+ + + ++ + + YY +T+ AV LGI + PG G +
Sbjct: 67 LIVPLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIV 126
Query: 117 E--------AGKQFQPKQAPPLVQTLL--NIIPTNPF----------------------- 143
E A K P LV+ + NII + F
Sbjct: 127 ETQTESIDKASKVLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSISPAQPMENWEF 186
Query: 144 --GALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGV 201
VL + F+++LG I R+R+ + L + L+EAM I + V
Sbjct: 187 KSAQREGSNVLGLVMFSVILGTTIG--------RMREKGQLLQDFFTTLSEAMMTITSWV 238
Query: 202 MQYAPIGV-FALIANVMASQGVKV-VGELAKVTVAVYVGLALQ----ILLVYFVLLKVFG 255
+ +P+GV F + A ++ + + + L + V +GL L I +++F+ +
Sbjct: 239 IWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRL- 297
Query: 256 IDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGATINMDGTA 315
P ++I+K + TAF T SSS T+P+T++ ++MGI + F +P+GATINMDGTA
Sbjct: 298 --PYRYIAKLSQVLATAFGTGSSSATMPLTIKCLDNMGIDPRVTRFVIPVGATINMDGTA 355
Query: 316 LYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLT 375
LY+ V FIA M + G + + +TA ASIG AG+P AG + + MVL++VGL
Sbjct: 356 LYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPK 415
Query: 376 DANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
D ++I+ +D +LD RT +NV D GT +V
Sbjct: 416 DV------SLIIAVDWLLDRFRTTINVMCDALGTILV 446
>gi|8394286 solute carrier family 1, member 2 [Rattus norvegicus]
>gi|347029|pir||S28901 glutamate transport protein - rat
>gi|56263|emb|CAA48042.1| (X67857) Glutamate transporter
[Rattus norvegicus] >gi|383571|prf||1903292A Glu
transporter [Rattus norvegicus]
Length = 573
Score = 192 bits (482), Expect = 8e-48
Identities = 151/457 (33%), Positives = 224/457 (48%), Gaps = 66/457 (14%)
Query: 12 VLQKILIGLILGAIVG--LILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
+L + G+ILGA+ G L L + D V P GD+ +R+LKML++P++ +SL+ G
Sbjct: 46 LLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFP-GDILMRMLKMLILPLIISSLITG 104
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAG---KQFQPKQ 126
+ + GR+G + +VYY+ T+ A LG+I+ +PG + G K +
Sbjct: 105 LSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSS 164
Query: 127 APPLVQTLLNIIPTNPFGAL------ANGKVL--PTIFFAIVLGIAITYL---MNSKDER 175
+ + N+ P N A KVL P A I+ L MN E
Sbjct: 165 LDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNEAPEE 224
Query: 176 VR---------KSAETLLNAIN-----GLAEAMYKIVA----GVMQYA------------ 205
+ K +L I G+A + GV+Q++
Sbjct: 225 TKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGVAGQADGGVLQHSERDCHEVSDHDH 284
Query: 206 ---PIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYFVLLKVFGI 256
P G+ LI ++A + ++VV +L + V VGL + + L+YFV+ +
Sbjct: 285 VVFPAGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRK--- 341
Query: 257 DPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGATINMDGTA 315
+P F + A +TA T SS+GTLPVT R ED +GI K + F LP+GATINMDGTA
Sbjct: 342 NPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTA 401
Query: 316 LYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLT 375
LY+ V FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L +VGLP
Sbjct: 402 LYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTE 461
Query: 376 DANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
D ++++ +D +LD RT VNV GD G IV
Sbjct: 462 D------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIV 492
>gb|AAB88289.1| (AF018259) glutamate transporter 5A [Ambystoma tigrinum]
Length = 564
Score = 191 bits (481), Expect = 1e-47
Identities = 145/457 (31%), Positives = 218/457 (46%), Gaps = 66/457 (14%)
Query: 17 LIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPA 76
++ +I+G ++G L + +Y + G+L +R+LKML++P+V +SL+ G A++
Sbjct: 26 VLSVIIGCLLGFFLRTRRLSQQEISYFQFPGELLMRMLKMLILPLVVSSLMSGLAALDAK 85
Query: 77 RLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQP--KQAPPLVQTL 134
R+G+ + YYL T+ AV +GI+M I +PG + +P A L+ +
Sbjct: 86 TSSRLGIITIAYYLWTTFVAVIVGIVMVSIIHPGGAAQKENTDQSGKPIMSSADALLDLI 145
Query: 135 LNIIPTNPFGA------------LANGKVLPT-------IFFAI---------------- 159
N+ P N A + GKV P+ + + I
Sbjct: 146 RNMFPANLVEATFKQYRTKNTPIVKTGKVPPSESITHRILVYGIQDENGSNIQNFALDIT 205
Query: 160 ------------------VLGIAI-TYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAG 200
VLGI I + M R+ S +++ L E++ KIVA
Sbjct: 206 PPPEVIYKSEPGTSEGMNVLGIVIFSATMGIMLGRMGTSGVPVVSFCQCLNESVMKIVAV 265
Query: 201 VMQYAPIGVFALIAN-VMASQGVKVVGE-LAKVTVAVYVGLALQILLVY-FVLLKVFGID 257
+ Y P G+ LIA ++ +G+ L + V GL + L + + L + +
Sbjct: 266 SVWYFPFGIVFLIAGKILEMDDPTAIGKKLGFYAITVVCGLVVHGLFILPMMYLFITKKN 325
Query: 258 PIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTAL 316
PI FI A+L A T SSS TLP+T + + E+ I + I F LP+GATINMDGTAL
Sbjct: 326 PIVFIRGVLQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTAL 385
Query: 317 YQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTD 376
Y+ V FIA L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP D
Sbjct: 386 YEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD 445
Query: 377 ANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVA 413
+I+ +D LD RTM+NV GD I+A
Sbjct: 446 ------ITLIIAVDWALDRFRTMINVLGDALAAGIMA 476
>gb|AAF73069.1|AF265360_1 (AF265360) GLAST-1a [Rattus norvegicus]
Length = 497
Score = 189 bits (475), Expect = 5e-47
Identities = 142/428 (33%), Positives = 210/428 (48%), Gaps = 74/428 (17%)
Query: 39 VKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVT 98
VK+Y+ F + FV L ++++VG A++ G++G++ VVYY+ T+ AV
Sbjct: 41 VKSYL--FRNAFVLL--------TVSAVIVGMAALDSKASGKMGMRAVVYYMTTTIIAVV 90
Query: 99 LGIIMARIFNPGAGI--TLAEAGKQFQPKQAPPLVQTLLNIIPTNPFGALANG------- 149
+GII+ I +PG G + GK Q A + + N+ P N A
Sbjct: 91 IGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTSYEK 150
Query: 150 -------KVLPTIFFAIVLGI--AITYLMNSKDERV------------------------ 176
+ T+ A++ + A+ L ++E V
Sbjct: 151 RSFKVPIQANETLLGAVINNVSEAMETLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFV 210
Query: 177 ----RKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANV---MASQGVKVVGELA 229
++ + L + L EA+ ++VA +M YAP+G+ LIA M GV + G+LA
Sbjct: 211 IGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLIAGKIVEMEDMGV-IGGQLA 269
Query: 230 KVTVAVYVGLALQILLV----YFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVT 285
TV V VGL + ++V YF++ + +P FI A++TA T SSS TLP+T
Sbjct: 270 MYTVTVIVGLLIHAVIVLPLLYFLVTRK---NPWVFIGGLLQALITALGTSSSSATLPIT 326
Query: 286 MR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLT 344
+ + E+ G+ K I F LP+GATINMDGTALY+ + FIA L GQ +TI +T
Sbjct: 327 FKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFDLNFGQIITISIT 386
Query: 345 AVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTG 404
A ASIG AG+P AG + + +VL SVGLP D +I+ +D LD RT NV G
Sbjct: 387 ATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ITLIIAVDWFLDRLRTTTNVLG 440
Query: 405 DLTGTAIV 412
D G IV
Sbjct: 441 DSLGAGIV 448
>pir||H83629 probable dicarboxylate transporter PA0119 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9945947|gb|AAG03509.1|AE004450_4 (AE004450) probable
dicarboxylate transporter [Pseudomonas aeruginosa]
Length = 449
Score = 188 bits (472), Expect = 1e-46
Identities = 116/419 (27%), Positives = 212/419 (49%), Gaps = 32/419 (7%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
+ +++IGL++G I G+ G D + +KP GD F++L+KML+ IVF +V G +
Sbjct: 15 IFLQVVIGLVIGVICGV-----GIPD-LAVQMKPLGDGFIKLIKMLIALIVFCVVVNGIS 68
Query: 72 SISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL----AEAGK------ 120
++GR+G+K V+Y+ + + A+ LG+++A G+G + AG
Sbjct: 69 GAGDLKKVGRIGLKSVIYFEILTTIALVLGLVVAYSLGLGSGANIHLNELPAGDVALYTG 128
Query: 121 QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
+ Q P V L+ +IPT+ F A A +L + F+++ G A+ V + A
Sbjct: 129 RTQEIHGP--VAFLMGLIPTSVFSAFAENDILQVLLFSVLFGSALNL--------VGEQA 178
Query: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA 240
+ IN + +++I+ +++ AP+GVF +A A GV + L + + Y
Sbjct: 179 SGVARLINEFSHIVFRIMGMIVRLAPLGVFGAVAFTTARYGVDSLSHLGALVLVFYATCL 238
Query: 241 LQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYS 300
+ ++ V +L++ G+ + F+ ++ +L T SS LP MR E MGI
Sbjct: 239 VFVMAVLGSVLRLSGVRMLPFLRYFREELLIVMGTASSDAVLPQVMRKLEHMGIRSSTVG 298
Query: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
+P G + N+DG ++Y + FIA+ G L + +TI+L +++ S G G+PG+
Sbjct: 299 LVIPTGYSFNLDGFSIYLTLAVVFIAHVTGTPLAMTDLITILLVSLVTSKGAHGIPGSAL 358
Query: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGEL 419
++LA L +V A A ++L +D + +GR + N+ G+ T +A+ E ++
Sbjct: 359 VILAATLTAV-----PAIPVAGLVLVLSVDWFMGIGRALTNLIGNCVATVTIARWENDI 412
>pir||A47131 Na+-dependent neutral amino acid transporter SATT - human
Length = 529
Score = 186 bits (468), Expect = 4e-46
Identities = 135/442 (30%), Positives = 217/442 (48%), Gaps = 67/442 (15%)
Query: 19 GLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARL 78
G++ GA +G L + TY+ G++ +R+++M+++P+V SLV +A ++ +L
Sbjct: 49 GVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRIVRMIILPLVVCSLV--SARLARCQL 106
Query: 79 GRV-GVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI-TLAEAGKQFQPKQAPPLVQTLL- 135
R G V Y+ LT+ A L + +A I PG+G TL + + PP+ + +
Sbjct: 107 PRASGRHRVAYFGLTTLTASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVD 166
Query: 136 -------NIIPTN------------------------------PFGALANG-KVLPTIFF 157
N+ P+N P G G +L + F
Sbjct: 167 SFLDLARNLFPSNLVVAAFRTYATDYEVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLF 226
Query: 158 AIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVM 217
A+VLG+A+ +++ E L+ N L EA +V+ +M Y P+G+ L+ + +
Sbjct: 227 ALVLGVAL--------KKLGSEGEDLIRFFNSLNEASMVLVSWIMWYVPVGIMFLVGSKI 278
Query: 218 ASQG--VKVVGELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISKAKDAMLT 271
+ +V L K A +G + + L+YFV + +P +F+ T
Sbjct: 279 VEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRK---NPFRFLLGLLAPFAT 335
Query: 272 AFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALG 330
AF T SSS TLP M+ + E+ G+ K I F LP+GAT+NMDG A++Q V FIA
Sbjct: 336 AFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNN 395
Query: 331 MHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGID 390
+ L GQ TI++TA +S+G AGVP G + +A++LE++GLP D +IL +D
Sbjct: 396 VELNAGQIFTILVTATASSVGAAGVPAPGVLTIAIILEAIGLPTHD------LPLILAVD 449
Query: 391 AILDMGRTMVNVTGDLTGTAIV 412
I+D T+VNV GD G I+
Sbjct: 450 WIVDRTTTVVNVEGDALGAGIL 471
>pir||A70681 probable dctA protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1666141|emb|CAB03776.1| (Z81451) dctA [Mycobacterium
tuberculosis]
Length = 491
Score = 185 bits (465), Expect = 8e-46
Identities = 118/406 (29%), Positives = 207/406 (50%), Gaps = 27/406 (6%)
Query: 16 ILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASI-S 74
++ +I G IVGL G + V G +FV L+KM++ P++F ++V+G S+
Sbjct: 30 VIFAVIAGVIVGLTAPSTGKSLTV------LGTVFVNLIKMMIAPVIFCTIVLGIGSVRK 83
Query: 75 PARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITL------AEAGKQFQPKQAP 128
A +G+VG + Y+L S+ A+ +G+I+ + +PG + L + A Q ++
Sbjct: 84 AAAVGKVGGLALAYFLTMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESH 143
Query: 129 PLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAIN 188
+ + IIP + AL G VL + A+++G A+ + + + E++L A+
Sbjct: 144 GIAGFIQQIIPRSLPSALTEGNVLQVLLVALLVGFAV--------QGLGPAGESILRAVE 195
Query: 189 GLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYF 248
L + ++K++ V+ APIG F IAN++A+ G V L + Y+ + + V
Sbjct: 196 NLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMAGFYLTCVVFVFGVLG 255
Query: 249 VLLKVF-GIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLPLGA 307
VLL++ G+ + + L F T SS LP + + +G+ +P G
Sbjct: 256 VLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHLGVQSSTVGVVVPTGY 315
Query: 308 TINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
+ N+DGTA+Y + + FIA+A+G LT G+Q+ ++ ++AS G AGV GAG LA L
Sbjct: 316 SFNLDGTAIYLTMASLFIADAMGHRLTWGEQIALLAFMIIASKGAAGVSGAGLATLAGGL 375
Query: 368 ESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVA 413
++ L D +I+GID + R++ N +G+ T +VA
Sbjct: 376 QAHRPELLD-----GVGLIVGIDRFMSEARSLTNFSGNAVATILVA 416
>gb|AAD22406.1|AF079997_3 (AF079997) DctA [Pseudomonas putida]
Length = 441
Score = 183 bits (460), Expect = 3e-45
Identities = 117/432 (27%), Positives = 213/432 (49%), Gaps = 42/432 (9%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFAS 65
K+ + ++++GL LG GL + D + +KP GD F++L+KML+ IVF
Sbjct: 3 KWCSRSIFLQVVLGLALGIACGL-----SFPD-LSLQLKPLGDGFIKLIKMLIGLIVFCV 56
Query: 66 LVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGIT---------- 114
+V G + + +GR+G+K V+Y+ + + A+ +G++ +F +GI
Sbjct: 57 VVSGISGAGDLKKVGRIGLKSVIYFEVLTTLALVIGLVFGLVFAFSSGIGSGANIHLDQL 116
Query: 115 -------LAEAGKQFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITY 167
LAE G+ A +++IPT+ GA A+ +L + F+++ G A+
Sbjct: 117 SSADANGLAERGQHIHGATA-----FFMDLIPTSVVGAFADNNILQVLLFSVLFGSALNL 171
Query: 168 LMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGE 227
V SA + IN L+ +++I+ +++ APIGVF IA + G++ +
Sbjct: 172 --------VGDSAAGISRLINELSHVIFRIMGMIVRLAPIGVFGAIAFTTSKYGLESLQH 223
Query: 228 LAKVTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR 287
L + Y+ A +L+V ++++ G+ + I ++ + T SS LP MR
Sbjct: 224 LGGLVALFYLTCAGFVLIVLGTVMRLSGLKLLPLIKYLREELTIVLGTASSDAVLPQIMR 283
Query: 288 VAEDMGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVL 347
E +GI +P G + N+DG ++Y + FIANA G L + LTI+L +++
Sbjct: 284 KLEHLGIGSSTVGLVIPTGYSFNLDGFSIYLTLAIVFIANATGTPLEMTDLLTILLVSLV 343
Query: 348 ASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLT 407
S G G+PG+ ++LA L +V A ++L +D + +GR + N+ G+
Sbjct: 344 TSKGAHGIPGSALVILAATLTAV-----PAIPVVGLVLVLAVDWFMGIGRALTNLIGNCV 398
Query: 408 GTAIVAKTEGEL 419
T +A+ E ++
Sbjct: 399 ATVAIARWEKDI 410
>gi|11429149 solute carrier family 1 (neuronal/epithelial high affinity
glutamate transporter, system Xag), member 1 [Homo
sapiens]
Length = 449
Score = 182 bits (458), Expect = 5e-45
Identities = 131/404 (32%), Positives = 194/404 (47%), Gaps = 75/404 (18%)
Query: 69 GAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPK 125
G A++ G++G++ VVYY T+ AV LGI++ PG + E G +
Sbjct: 3 GVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVS 62
Query: 126 QAPPLVQTLLNIIPTNPF------------------------------------------ 143
++ + N+ P N
Sbjct: 63 TVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKT 122
Query: 144 ------GALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYK 196
G ++G VL I F +V G+ I ++ + + L++ N L++A K
Sbjct: 123 KEYKIVGMYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMK 174
Query: 197 IVAGVMQYAPIGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLL 251
IV +M Y P+G+ LIA ++ + ++ +L V GLA+ + L+YF+++
Sbjct: 175 IVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVV 234
Query: 252 KVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATIN 310
+ +P +F A+LTA + SSS TLPVT R AE+ + K I F LP+GATIN
Sbjct: 235 RK---NPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATIN 291
Query: 311 MDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESV 370
MDGTALY+ V FIA + L +GQ +TI +TA ASIG AGVP AG + + +VL +V
Sbjct: 292 MDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAV 351
Query: 371 GLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
GLP D +I+ +D +LD RTMVNV GD GT IV K
Sbjct: 352 GLPAEDV------TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 389
>gb|AAD47830.1|AF166000_1 (AF166000) sodium-dependent excitatory amino acid transporter 2
[Drosophila melanogaster]
Length = 561
Score = 180 bits (453), Expect = 2e-44
Identities = 139/471 (29%), Positives = 230/471 (48%), Gaps = 80/471 (16%)
Query: 3 WLKKYLEFPVLQKILIGLILGAIVGLILGHYG-YADAVKTYIKPFGDLFVRLLKMLVMPI 61
WL + L +L L G++LG I+GL L + D++ P G+LF+R+LK++++P+
Sbjct: 29 WLSENL---MLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYP-GELFMRVLKLMILPL 84
Query: 62 VFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ 121
V +SL+ G+AS++ G++ ++ +VY+ TS F LGI + + +PG L A +
Sbjct: 85 VISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPG-NPDLHNADDR 143
Query: 122 FQPKQAPPLVQTLL----NIIPTNPFGA--------------------------LANGK- 150
++A L+ +LL N+ P N F A LA+G
Sbjct: 144 STDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNETMNDTLASGSE 203
Query: 151 -------------------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
L +FF +V G T+L + + + +++
Sbjct: 204 AQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFG---TFLGT-----IGQKGQVVVD 255
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVK--VVGELAKVTVAVYVGLAL-Q 242
+ E + K+V VM P+G+ ++IA + S G V+ +L V V +G+ + Q
Sbjct: 256 FFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQ 315
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSF 301
+++ + V +P KF + AMLTAF T S++ LP+T R + E + + I F
Sbjct: 316 FVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMDEKLKVDPRITRF 375
Query: 302 TLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAI 361
LP+G INMDGTALY V + FIA GM L G+ LT++LT+ AS+ +A VP A +
Sbjct: 376 VLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALV 435
Query: 362 MLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+L +VL ++ P+ D ++ +D +D RT N+ GD A+V
Sbjct: 436 LLLVVLTAIDAPVQDV------TLLFAVDWFVDRIRTTNNMLGDCYTAAVV 480
>gb|AAF51466.1| (AE003588) Eaat2 gene product [Drosophila melanogaster]
Length = 563
Score = 180 bits (453), Expect = 2e-44
Identities = 139/471 (29%), Positives = 230/471 (48%), Gaps = 80/471 (16%)
Query: 3 WLKKYLEFPVLQKILIGLILGAIVGLILGHYG-YADAVKTYIKPFGDLFVRLLKMLVMPI 61
WL + L +L L G++LG I+GL L + D++ P G+LF+R+LK++++P+
Sbjct: 29 WLSENL---MLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYP-GELFMRVLKLMILPL 84
Query: 62 VFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQ 121
V +SL+ G+AS++ G++ ++ +VY+ TS F LGI + + +PG L A +
Sbjct: 85 VISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPG-NPDLHNADDR 143
Query: 122 FQPKQAPPLVQTLL----NIIPTNPFGA--------------------------LANGK- 150
++A L+ +LL N+ P N F A LA+G
Sbjct: 144 STDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNETMNDTLASGSE 203
Query: 151 -------------------------VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
L +FF +V G T+L + + + +++
Sbjct: 204 AQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFG---TFLGT-----IGQKGQVVVD 255
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVK--VVGELAKVTVAVYVGLAL-Q 242
+ E + K+V VM P+G+ ++IA + S G V+ +L V V +G+ + Q
Sbjct: 256 FFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQ 315
Query: 243 ILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSF 301
+++ + V +P KF + AMLTAF T S++ LP+T R + E + + I F
Sbjct: 316 FVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRF 375
Query: 302 TLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAI 361
LP+G INMDGTALY V + FIA GM L G+ LT++LT+ AS+ +A VP A +
Sbjct: 376 VLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALV 435
Query: 362 MLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
+L +VL ++ P+ D ++ +D +D RT N+ GD A+V
Sbjct: 436 LLLVVLTAIDAPVQDV------TLLFAVDWFVDRIRTTNNMLGDCYTAAVV 480
>emb|CAC12702.1| (AL136231) bA6J24.1 (solute carrier family 1 (neuronal/epithelial
high affinity glutamate transporter, system Xag), member
1) [Homo sapiens]
Length = 446
Score = 180 bits (453), Expect = 2e-44
Identities = 129/394 (32%), Positives = 190/394 (47%), Gaps = 75/394 (19%)
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQPKQAPPLVQTLL 135
G++G++ VVYY T+ AV LGI++ PG + E G + ++ +
Sbjct: 10 GKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIR 69
Query: 136 NIIPTNPF------------------------------------------------GALA 147
N+ P N G +
Sbjct: 70 NMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYS 129
Query: 148 NG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAP 206
+G VL I F +V G+ I ++ + + L++ N L++A KIV +M Y P
Sbjct: 130 DGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIVQIIMCYMP 181
Query: 207 IGVFALIAN-VMASQGVKVVGELAKVTVAVYVGLALQIL----LVYFVLLKVFGIDPIKF 261
+G+ LIA ++ + ++ +L V GLA+ + L+YF++++ +P +F
Sbjct: 182 LGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRK---NPFRF 238
Query: 262 ISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDGTALYQGV 320
A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMDGTALY+ V
Sbjct: 239 AMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAV 298
Query: 321 CTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVA 380
FIA + L +GQ +TI +TA ASIG AGVP AG + + +VL +VGLP D
Sbjct: 299 AAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDV--- 355
Query: 381 AAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
+I+ +D +LD RTMVNV GD GT IV K
Sbjct: 356 ---TLIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 386
>sp|P77529|YDJN_ECOLI HYPOTHETICAL SYMPORTER YDJN >gi|7451170|pir||A64932 hypothetical
protein b1729 - Escherichia coli (strain K-12)
>gi|1742823|dbj|BAA15509.1| (D90815)
Proton/sodium-glutamate symport protein
(Glutamate-aspartate carrier protein). [Escherichia
coli] >gi|1742828|dbj|BAA15512.1| (D90816)
Proton/sodium-glutamate symport protein
(Glutamate-aspartate carrier protein). [Escherichia
coli] >gi|1788024|gb|AAC74799.1| (AE000268) part of a
kinase [Escherichia coli K12]
Length = 463
Score = 178 bits (448), Expect = 8e-44
Identities = 129/435 (29%), Positives = 231/435 (52%), Gaps = 41/435 (9%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADA--VKTYIKPF---GDLFVRLLKMLVMP 60
++ ++ + +K+L+GL++G + GL L +D+ +K ++ F G+ +V+LL+M+VMP
Sbjct: 23 RHKQWSLAKKVLVGLVMGVVFGLALHTIYGSDSQVLKDSVQWFNIVGNGYVQLLQMIVMP 82
Query: 61 IVFASLVVGAASISPA-RLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGIT---LA 116
+VFAS++ A + A +LG++ + L T+ A +G+++ +F G+T L
Sbjct: 83 LVFASILSAVARLHNASQLGKISFLTIGTLLFTTLIAALVGVLVTNLF----GLTAEGLV 138
Query: 117 EAGKQFQPKQAPP-----------LVQTLLNIIPTNPFGALANGK---VLPTIFFAIVLG 162
+ G + A + Q +L+ IP NPF L ++ + FA LG
Sbjct: 139 QGGAETARLNAIESNYVGKVSDLSVPQLVLSFIPKNPFADLTGANPTSIISVVIFAAFLG 198
Query: 163 IAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGV 222
+A L+ KD+ + E +L AI+ L + K+V VMQ P GV AL+ V+A +
Sbjct: 199 VAALKLL--KDDAPK--GERVLAAIDTLQSWVMKLVRLVMQLTPYGVLALMTKVVAGSNL 254
Query: 223 KVVGELAKVTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTL 282
+ + +L VA Y+GL L + V+ +LL + G+ P+K+ K + AF +RSS+ ++
Sbjct: 255 QDIIKLGSFVVASYLGL-LIMFAVHGILLGINGVSPLKYFRKVWPVLTFAFTSRSSAASI 313
Query: 283 PVTMRV-AEDMGISKGIYSFTLPLGATINMDGTA-LYQGVCTFFIANALGMH-LTLGQQL 339
P+ + +G+ + I SF GATI +G A LY + +A +G++ L
Sbjct: 314 PLNVEAQTRRLGVPESIASFAASFGATIGQNGCAGLYPAMLAVMVAPTVGINPLDPMWIA 373
Query: 340 TIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTM 399
T+V ++S G AGV G +VL ++GLP+T A+++ ++ ++DMGRT
Sbjct: 374 TLVGIVTVSSAGVAGVGGGATFAALIVLPAMGLPVT------LVALLISVEPLIDMGRTA 427
Query: 400 VNVTGDLTGTAIVAK 414
+NV+G +T + ++
Sbjct: 428 LNVSGSMTAGTLTSQ 442
>gb|AAB71739.1| (U75214) mEAAC2 [Mus musculus]
Length = 375
Score = 177 bits (444), Expect = 2e-43
Identities = 111/270 (41%), Positives = 156/270 (57%), Gaps = 23/270 (8%)
Query: 151 VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVF 210
VL I F +V G+ I ++ + + L++ N L++A KIV +M Y PIG+
Sbjct: 63 VLGLIIFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIVQIIMCYMPIGIL 114
Query: 211 ALIAN-VMASQGVKVVGELAKVTVAVYVGLALQILLV----YFVLLKVFGIDPIKFISKA 265
LIA ++ + ++ +L V GLA+ L+V YF++++ +P +F
Sbjct: 115 FLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLIVLPLLYFIVVRK---NPFRFALGM 171
Query: 266 KDAMLTAFVTRSSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDGTALYQGVCTFF 324
A+LTA + SSS TLPVT R AE+ + K I F LP+GATINMDGTALY+ V F
Sbjct: 172 AQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATINMDGTALYEAVAAVF 231
Query: 325 IANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYA 384
IA G+ L++GQ +TI +TA ASIG AGVP AG + + +VL +VGLP D
Sbjct: 232 IAQLNGLDLSIGQIVTISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDV------T 285
Query: 385 MILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
+I+ +D +LD RTMVNV GD GT IV K
Sbjct: 286 LIIAVDWLLDRFRTMVNVLGDAFGTGIVEK 315
>pir||B81325 probable C4-dicarboxylate transport protein Cj1192 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968625|emb|CAB73446.1| (AL139077) putative
C4-dicarboxylate transport protein [Campylobacter
jejuni]
Length = 458
Score = 176 bits (442), Expect = 4e-43
Identities = 116/427 (27%), Positives = 218/427 (50%), Gaps = 39/427 (9%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
+++ + +I+G I G++LG+ A+ + KP D F+ LK+L+ PI+F +LV+G
Sbjct: 19 IIKSLGFWVIIGIITGIVLGYTDKELAIAS--KPGVDYFIGALKVLIGPIIFVTLVLGII 76
Query: 72 SI-SPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQ---- 126
S+ S ++G +G K V+Y+ + S A+ +GI MA + PG G+ L + + Q
Sbjct: 77 SLESLKKVGSIGAKAVIYFEVVSTLALAIGIFMANVMQPGHGMNLDPSQLDTKSVQKYIS 136
Query: 127 -------APPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKS 179
+ ++ L + +PT+ GK + + AI+ + I+ + + +++
Sbjct: 137 QTTEVSASSEIMHILKDAMPTDIITPFTEGKTIQVLVIAIITALIISLMRIEDKQAIQRV 196
Query: 180 AETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGL 239
E + N + +KI+ +M ++PI F+ +A ++A G+ + LA + + + +
Sbjct: 197 FEVVQNFV-------FKILQIIMYFSPIAAFSAMAVLIAQYGIGSLINLAYLLLVMLISC 249
Query: 240 ALQI-----LLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGI 294
+ I L+ YF + +F ++FIS+ +L F T SS L MR E G+
Sbjct: 250 LVFIFGILGLICYFAKVNIFKF--MRFISRE---VLIVFATSSSESALAPLMRKLEKAGL 304
Query: 295 SKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAG 354
SK LP G + N+D T +Y + F+A A ++L+L +++I++ ++AS G G
Sbjct: 305 SKATVGLVLPTGYSFNLDCTNIYLAMSLIFLAQAFNVNLSLAHEISILIVLMIASKGAVG 364
Query: 355 VPGAGAIMLAMVLESVG-LPLTDANV-------AAAYAMILGIDAILDMGRTMVNVTGDL 406
V G+G I+L L ++G + +++AN AA ++LG+D + R + N+ G+
Sbjct: 365 VTGSGFIVLGSTLAALGNMEISEANATLAQVLPVAAIGVLLGVDKFMSEMRAVGNLCGNS 424
Query: 407 TGTAIVA 413
IVA
Sbjct: 425 VAALIVA 431
>gb|AAD34586.1|AF144379_1 (AF144379) glutamate transporter Am-EAAT [Apis mellifera]
Length = 543
Score = 175 bits (440), Expect = 7e-43
Identities = 131/437 (29%), Positives = 205/437 (45%), Gaps = 49/437 (11%)
Query: 16 ILIGLILGAIVGLILGHYGY----ADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
+L+ I +VGLILG G T I G+L +RLLKM ++P++ +SL+ G A
Sbjct: 65 LLVFTIAAVLVGLILGFLGRLANPTPQSITLISFPGELLMRLLKMFILPLIVSSLISGMA 124
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPG----AGITLAEAGKQFQPKQA 127
+ P GR+G + ++YY +T+ A +GI+M I +PG + A +
Sbjct: 125 QLDPKGSGRMGYRALLYYTVTTILAAIVGIVMVLIIHPGDPRIKSVVTAYKADYTKISTL 184
Query: 128 PPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAI 187
++ + N++P N A + + G A + V K ++ I
Sbjct: 185 DAILDIIRNMVPENLVQACFQQAQTTYVTKEVATGTASEITQIQEATLVYKDGTNVMGMI 244
Query: 188 ---------------NG---------LAEAMYKIVAGV-MQYAPIGVFALIAN-VMASQG 221
G L E + K+V + M Y+P G+ LIA +M+
Sbjct: 245 VFCITFGLVAGQFGAQGKLIVDFFMILNEIIMKLVGIIIMWYSPFGIMCLIAGKIMSINN 304
Query: 222 VKVVGE-LAKVTVAVYVGLALQILL----VYFVLLKVFGIDPIKFISKAKDAMLTAFVTR 276
+ + L V V +GL L+ +++ L + +P F A +TA T
Sbjct: 305 LTATAQMLGLYMVTVILGLLFHALITLPTIFWFLTRQ---NPAAFFRGMMQAWMTALGTA 361
Query: 277 SSSGTLPVTMRVAEDMG-ISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTL 335
SS+ TLP+T R E+ I + F + +GAT+NMDGTALY+ V FIA G+ L +
Sbjct: 362 SSAATLPITFRCLEENNKIDSRVTRFVVAVGATVNMDGTALYEAVAAIFIAQMNGISLGI 421
Query: 336 GQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDM 395
G+ +T+ TA LASIG A +P A I + +VL ++GLP D +++ +D +LD
Sbjct: 422 GEVITVSFTATLASIGAASIPSAALITMLIVLTALGLPTND------ISLLFAVDWMLDR 475
Query: 396 GRTMVNVTGDLTGTAIV 412
RT +NV GD G IV
Sbjct: 476 IRTSINVLGDGYGAGIV 492
>gb|AAF14543.2|AF167077_1 (AF167077) glutamate transporter [Canis familiaris]
Length = 564
Score = 170 bits (427), Expect = 2e-41
Identities = 112/302 (37%), Positives = 166/302 (54%), Gaps = 28/302 (9%)
Query: 131 VQTLLNIIPTNPFGALANG-KVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAING 189
+Q +L+ T P ANG L + F++ G+ I V+ L + +
Sbjct: 247 LQEVLSFEETVPVPGSANGINALGLVVFSVAFGLVIG--------GVKHKGRVLRDFFDS 298
Query: 190 LAEAMYKIVAGVMQYAPIGVFALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----I 243
L EA+ ++V ++ YAP+G+ LIA ++ + + V+G +L T+ V VGL L +
Sbjct: 299 LNEAIMRMVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVL 358
Query: 244 LLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFT 302
L+YF++ +P FI A++TA T SSS TLP+T R E+ +G+ + I F
Sbjct: 359 PLIYFLITHR---NPFPFIGGVLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFV 415
Query: 303 LPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIM 362
LP+GAT+NMDGTALY+ + FIA L LGQ TI +TA AS+G AG+P AG +
Sbjct: 416 LPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVT 475
Query: 363 LAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV---AKTEGEL 419
+ +VL SVGLP D +I+ +D LD RTM NV GD G A++ ++ E EL
Sbjct: 476 MVIVLTSVGLPTED------ITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELEL 529
Query: 420 KE 421
+E
Sbjct: 530 QE 531
Score = 71.4 bits (172), Expect = 2e-11
Identities = 40/124 (32%), Positives = 66/124 (52%), Gaps = 2/124 (1%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
+++G + L Y Y G+L +R+L+MLV+P++ +SLV G AS+ G
Sbjct: 66 VVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATG 125
Query: 80 RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGIT--LAEAGKQFQPKQAPPLVQTLLNI 137
R+G++ VYY++T+ AV +GI+M I +PG G L G+ A + + N+
Sbjct: 126 RMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMDLVRNM 185
Query: 138 IPTN 141
P N
Sbjct: 186 FPPN 189
>sp|P54596|YHCL_BACSU HYPOTHETICAL SYMPORTER YHCL >gi|7451171|pir||H69822
sodium-glutamate symporter homolog yhcL - Bacillus
subtilis >gi|1239988|emb|CAA65696.1| (X96983)
hypothetical protein [Bacillus subtilis]
>gi|2633236|emb|CAB12741.1| (Z99108) similar to
sodium-glutamate symporter [Bacillus subtilis]
Length = 463
Score = 169 bits (424), Expect = 5e-41
Identities = 118/440 (26%), Positives = 222/440 (49%), Gaps = 31/440 (7%)
Query: 5 KKYLEFP--VLQKILIGLILGAIVGLILGHYGYADAVKT--YIKPFGDLFVRLLKMLVMP 60
KK++ F V + +G++ G + LI G ++T + G +V+LL+M+VMP
Sbjct: 25 KKHVSFSKRVFTALGLGIVFGFALQLIYGPTSNI-VIQTADWFNIAGGGYVKLLQMVVMP 83
Query: 61 IVFASLVVGAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGA-----GIT 114
+VF S++ + + LG++ I+ + T+A A +GI A F+ A G T
Sbjct: 84 LVFISILGAFTKLKLTKNLGKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGST 143
Query: 115 LAEAGKQFQPKQ----APPLVQTLLNIIPTNPFGALANGKVLPTI---FFAIVLGIAITY 167
G++ Q K A L Q ++ ++P NPF + TI FA LG+A
Sbjct: 144 ELSRGQELQQKSEDMTAKTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLG 203
Query: 168 LMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGE 227
+ + + E+ AET ++ + + ++V +++ P GV A++ +A+ + + +
Sbjct: 204 VKHKQPEQ----AETFKKLVDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILK 259
Query: 228 LAKVTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR 287
L +A Y L + + +++ +LL G++P+ ++ KA ++ AF +RSS+G LP+ ++
Sbjct: 260 LGMFVIASYAAL-ITMFIIHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIK 318
Query: 288 VAEDMGISKGIYSFTLPLGATINMDGTA-LYQGVCTFFIANALGMH-LTLGQQLTIVLTA 345
MG+ +GI +F G +I +G A +Y + IA +G + +T++
Sbjct: 319 TQRSMGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVV 378
Query: 346 VLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGD 405
++S G AGV G +VL S+ +P+ A +++ I+ ++DMGRT +NV+G
Sbjct: 379 AISSFGVAGVGGGATFAALLVLSSLNMPV------ALAGLLISIEPLIDMGRTALNVSGS 432
Query: 406 LTGTAIVAKTEGELKEGIIY 425
+T I +K E+ +G +
Sbjct: 433 MTSGLITSKVTKEIDQGAFH 452
>gb|AAB32664.1| (S75687) glutamate/aspartate transporter, GLAST [rats,
Sprague-Dawley, cochleae, Peptide Partial, 330 aa]
[Rattus sp.]
Length = 330
Score = 167 bits (419), Expect = 2e-40
Identities = 110/283 (38%), Positives = 155/283 (53%), Gaps = 30/283 (10%)
Query: 138 IPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKI 197
+P + G A G V+ ++ F V+G +++ + L + L EA+ ++
Sbjct: 63 VPGSVNGVNALGLVVFSMCFGFVIG------------NMKEQGQALREFFDSLNEAIMRL 110
Query: 198 VAGVMQYAPIGVFALIANV---MASQGVKVVGELAKVTVAVYVGLALQILLV----YFVL 250
VA +M YAP+G+ LIA M GV + G+LA TV V VGL + ++V YF++
Sbjct: 111 VAVIMWYAPLGILFLIAGKILEMEDMGV-IGGQLAMYTVTVIVGLLIHAVIVLPLLYFLV 169
Query: 251 LKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATI 309
+ +P FI A++TA T SSS TLP+T + + E+ G+ K I F LP+GATI
Sbjct: 170 TRK---NPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATI 226
Query: 310 NMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLES 369
NMDGTALY+ + FIA L GQ +TI +TA ASIG AG+P AG + + +VL S
Sbjct: 227 NMDGTALYEALAAIFIAQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTS 286
Query: 370 VGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
VGLP D +I+ +D LD RT NV GD G IV
Sbjct: 287 VGLPTDD------ITLIIAVDWFLDRLRTTTNVLGDSLGAGIV 323
>pir||D81418 probable transmembrane symporter Cj0025c [imported] - Campylobacter
jejuni (strain NCTC 11168) >gi|6967530|emb|CAB72518.1|
(AL139074) putative transmembrane symporter
[Campylobacter jejuni]
Length = 461
Score = 166 bits (417), Expect = 3e-40
Identities = 110/369 (29%), Positives = 189/369 (50%), Gaps = 12/369 (3%)
Query: 49 LFVRLLKMLVMPIVFASLVVGAASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIF 107
+FV +KMLV+P+V ++ I ++ + + + L ++A A TLGI + F
Sbjct: 90 VFVAFIKMLVVPLVSICIIKVIIEIDKNIKISSLLGISLFWILFSTAIAATLGIFLGYSF 149
Query: 108 NPGAGITLAEAGKQFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITY 167
+ G+ + E KQ + Q +L +IP+N A+ ++ + F+ +GI+
Sbjct: 150 DLGSNFAIYEGDKQIREIQT--FSNIILGLIPSNIITAINKENIIAIVIFSFFIGISAKK 207
Query: 168 LMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGE 227
+ SK E ++ ++ N I M + A V+++ P V ++ANV+ S G + +
Sbjct: 208 I--SKKEEYEQAFKSFHNFILTFYNIMMNMTATVIRFMPYAVVCMMANVLLSNGFEAIKT 265
Query: 228 LAKVTVAVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMR 287
+ +Y+ + + + V+F+LL G++PIK+ KA L AF +RSS GTLP+T
Sbjct: 266 AGLFIMLIYIAMFI-MFGVHFLLLASQGLNPIKYAKKAFPVWLFAFSSRSSLGTLPMTTS 324
Query: 288 VAED-MGISKGIYSFTLPLGATINMDGTALY-QGVCTFFIANALGMHLTLGQQLTIVLTA 345
++ G++ I +F +G T ++G A Y + F+A A H+ L IVL A
Sbjct: 325 TLQNKFGVNSAIANFVASIGTTTGLNGCAGYFPALAAVFVAFATHTHIDFTFALMIVLVA 384
Query: 346 VLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGD 405
V+ S+G AGVPG+ + +++L +G N ++IL ID I+DM RT NV+G
Sbjct: 385 VIGSLGIAGVPGSATMAASIMLAGIGF----GNNFVMLSLILAIDPIIDMARTASNVSGA 440
Query: 406 LTGTAIVAK 414
+T AK
Sbjct: 441 MTSALCTAK 449
>gb|AAA93062.1| (U15098) GluT-R glutamate transporter [Rattus norvegicus]
Length = 453
Score = 166 bits (415), Expect = 6e-40
Identities = 107/269 (39%), Positives = 155/269 (56%), Gaps = 24/269 (8%)
Query: 151 VLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVF 210
VL I F I GIA+ ++ + A+ ++ N L E + K+V +M Y+P+G+
Sbjct: 121 VLGLIGFFIAFGIAMG--------KMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIA 172
Query: 211 ALIAN-VMASQGVKVVG-ELAKVTVAVYVGLALQ----ILLVYFVLLKVFGIDPIKFISK 264
LI ++A + ++VV +L + V VGL + + L+YFV+ + +P F +
Sbjct: 173 CLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRK---NPFSFFAG 229
Query: 265 AKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGATINMDGTALYQGVCTF 323
A +TA T SS+GTLPVT R ED +GI K + F LP+GATINMDGTALY+ V
Sbjct: 230 IFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAI 289
Query: 324 FIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAY 383
FIA G+ L GQ +T+ LTA LASIG A +P AG + + ++L +VGLP D
Sbjct: 290 FIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTED------I 343
Query: 384 AMILGIDAILDMGRTMVNVTGDLTGTAIV 412
++++ +D +LD RT VNV GD G IV
Sbjct: 344 SLLVAVDWLLDRMRTSVNVVGDSFGAGIV 372
>sp|P45079|YDJN_HAEIN HYPOTHETICAL SYMPORTER HI1154 >gi|1075186|pir||D64186 conserved
hypothetical protein HI1154 - Haemophilus influenzae
(strain Rd KW20) >gi|1574711|gb|AAC22809.1| (U32795)
proton glutamate symport protein, putative [Haemophilus
influenzae Rd]
Length = 440
Score = 162 bits (407), Expect = 5e-39
Identities = 118/417 (28%), Positives = 205/417 (48%), Gaps = 30/417 (7%)
Query: 14 QKILIGLILGAIVGLILG---HYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGA 70
Q + IGL+LG + G +L D +I + +VRLL+M+VMP+VF S++
Sbjct: 28 QTVFIGLLLGLLFGAVLQSAFEKPLLDKTLDWINVVSNGYVRLLQMIVMPLVFVSILSAI 87
Query: 71 ASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFN-PGAGITLAEAGKQFQPKQAP 128
A I+ R LG+V V ++ L+T+A + +GI M +F+ AG+ + + Q K
Sbjct: 88 ARINQTRSLGKVSVGVLSTLLITTAISAAIGIAMVHLFDVSAAGLIVGDRELAAQGKVLD 147
Query: 129 PLVQT--------LLNIIPTNPFGALANG---KVLPTIFFAIVLGIAITYLMNSKDERVR 177
Q L++ IP NPF L ++ + F+ +LG+A L +D+ +
Sbjct: 148 KAGQVSNLTVPAMLVSFIPKNPFADLTGANPTSIISVVIFSALLGVAALSL-GKEDQAL- 205
Query: 178 KSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYV 237
E + + L + + ++V V++ P GVFAL+ + A+ + L VA Y
Sbjct: 206 --GERIAQGVETLNKLVMRLVRFVIRLTPYGVFALMIKMAATSKWADIVNLGNFIVASYA 263
Query: 238 GLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRV-AEDMGISK 296
+AL + +V+ +LL ++P+ + K + AF +RSS+ T+P+ + +G +
Sbjct: 264 AIAL-MFVVHGILLFFVKVNPVDYYKKVLPTLSFAFTSRSSAATIPLNIETQTAKLGNNN 322
Query: 297 GIYSFTLPLGATINMDGT-ALYQGVCTFFIANALGMH-LTLGQQLTIVLTAVLASIGTAG 354
I +F GATI +G +Y + +A +G+ + LT++ ++S G AG
Sbjct: 323 VIANFAATFGATIGQNGCGGIYPAMLAVMVAPMVGIDPFSFSYILTLIFVVAISSFGIAG 382
Query: 355 VPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAI 411
V G +VL ++GLPL +++ I+ I+DMGRT +NV G + I
Sbjct: 383 VGGGATFAAIVVLSTLGLPL------ELIGLLISIEPIIDMGRTALNVNGAMVAGTI 433
>pir||F82223 sodium/dicarboxylate symporter VC1235 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9655717|gb|AAF94394.1|
(AE004203) sodium/dicarboxylate symporter [Vibrio
cholerae]
Length = 471
Score = 160 bits (401), Expect = 3e-38
Identities = 116/431 (26%), Positives = 217/431 (49%), Gaps = 36/431 (8%)
Query: 14 QKILIGLILGAIVGLIL------GHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLV 67
+++L GL+LG+ GL L GH + + +++ G+ +V LLKM++MP+V S++
Sbjct: 45 RQVLFGLVLGSAFGLALQVVLGEGHPAIQETL-SWVAIVGNGYVGLLKMVIMPLVLVSMI 103
Query: 68 VGAASISP-ARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFN-------PGAGITLAEAG 119
+ LG++ + L+T+A + +GI++ + F GA T A
Sbjct: 104 SAVVRLDKNGSLGKISSLTIGILLVTTAISALIGILITQAFGLTAEGLVEGARETARIAA 163
Query: 120 KQFQPKQAPPLV--QTLLNIIPTNPFGALANGK---VLPTIFFAIVLGIAITYLMNSKDE 174
+ + L Q LL+ IPTNPF L + ++ + F ++ GIA ++ K E
Sbjct: 164 LESRASTVADLTIPQILLSFIPTNPFADLTGARSTSIIAVVIFGVLTGIAARKVIADKQE 223
Query: 175 RVRKSAETLLNAINGLAEAMY-KIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTV 233
ET + A+A+ ++V +M P G+ AL+A V+A+ + L V
Sbjct: 224 -----LETPIRTFVEAAQAIVMRLVKMIMALTPYGIAALMAKVVATSSATDILNLLGFIV 278
Query: 234 AVYVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVA-EDM 292
A YV +AL + +V+ +L+ + G++P ++ + AF +RSS+ T+P+ + +
Sbjct: 279 ASYVAIAL-MFVVHGLLVAMVGVNPTRYFKNIWPVLTFAFTSRSSAATIPLNVEAQITKL 337
Query: 293 GISKGIYSFTLPLGATINMDGTA-LYQGVCTFFIANALGMH-LTLGQQLTIVLTAVLASI 350
+ I + + GATI +G A +Y + +A +G++ L + ++++ ++S
Sbjct: 338 NVPPAIANLSASFGATIGQNGCAGIYPAMLAVMVAPTVGINPLDIHFIVSLIAMITISSF 397
Query: 351 GTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTA 410
G AGV G +VL ++GLP+T A A+++ I+ ++DM RT +NV+G +T
Sbjct: 398 GIAGVGGGATFAALIVLPAMGLPVTIA------ALLISIEPLIDMARTALNVSGSMTAGT 451
Query: 411 IVAKTEGELKE 421
+ ++ E E
Sbjct: 452 VTSRLLKETNE 462
>sp|Q21751|EAT3_CAEEL PUTATIVE SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER R05G6.6
>gi|7506319|pir||T29354 hypothetical protein R05G6.6 -
Caenorhabditis elegans >gi|1326334|gb|AAB00621.1|
(U58746) similar to the sodium:dicarboxylate symporter
family [Caenorhabditis elegans]
Length = 575
Score = 158 bits (396), Expect = 1e-37
Identities = 136/484 (28%), Positives = 215/484 (44%), Gaps = 100/484 (20%)
Query: 9 EFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVV 68
E +L + + LG ++G L + I G++F+++LKM+++P++F+SL+
Sbjct: 15 ENTLLVMTMFSVFLGVVLGFGLRPLNLSQETLQLINFPGEIFMQVLKMMILPLIFSSLIS 74
Query: 69 GA-----------------ASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPG- 110
G A + G++G V+YYL T+ A LGI + + +PG
Sbjct: 75 GELKLKQLQAFEVQKSVTLAQMDAKESGQMGASTVLYYLSTAVLATILGIFLVTVIHPGD 134
Query: 111 ---AGITLAEAGKQFQPKQAPPLVQTLLNIIPTN-----------------PFGALANG- 149
G ++EA + + N+ P N P A NG
Sbjct: 135 PSIKGTDISEAPSDGNVSPLDTFLDLVRNMFPENIIQATFERMQTTYVAIRPKIASKNGT 194
Query: 150 ----------------KVLPTIFFAIVLGIAITYLMNSKDERVRKSAE--TLLNAINGLA 191
+L I F GI I+ L ER R + +L+A+
Sbjct: 195 SGNIIVKRSIGMTKGMNILGIIVFCTGFGIVISQL----GERARIVVDFFVILDAV---- 246
Query: 192 EAMYKIVAGVMQYAPIGVFALIA-NVMASQGVK-VVGELAKVTVAVYVGLALQIL----L 245
+ + V +M +AP+G+ LI N++ + + LA V GL L + L
Sbjct: 247 --IMRWVVTLMWFAPLGITCLICGNLLELDDISDIASVLALYVFTVCAGLILHTIITVPL 304
Query: 246 VYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSS----------------GTLPVTMRVA 289
+YF + + +P+ A +TAF T S S TLP++M+
Sbjct: 305 MYFFITRE---NPLPIFKGMIQAAVTAFGTASGSPKNIRKLTITKNDYVGATLPMSMQCL 361
Query: 290 ED-MGISKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLA 348
ED G+ + I F LPLG+TINMDG ALY+ V FIA + L+L + LT+ +TA +A
Sbjct: 362 EDHCGVDRRISRFVLPLGSTINMDGNALYEAVAVIFIAQLNNVQLSLAEVLTVSITATIA 421
Query: 349 SIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTG 408
SIG VP AG + + ++L +VGLP+ D +M+ +D +LD RT VNV GD
Sbjct: 422 SIGLGSVP-AGLVSILLILNTVGLPVRDV------SMLFTVDWLLDRVRTAVNVLGDAFA 474
Query: 409 TAIV 412
++V
Sbjct: 475 ASMV 478
>pir||C83391 probable transporter (membrane subunit) PA2042 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9948048|gb|AAG05430.1|AE004630_7 (AE004630) probable
transporter (membrane subunit) [Pseudomonas aeruginosa]
Length = 409
Score = 151 bits (378), Expect = 1e-35
Identities = 116/419 (27%), Positives = 209/419 (49%), Gaps = 28/419 (6%)
Query: 7 YLEFPVLQKI----LIG-LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPI 61
Y E P+L + L+G +I+G I GL+L + A A+K G +FV LK + +
Sbjct: 3 YPERPLLHLLTRTSLVGQIIVGLIAGLLLASFFPAAALKVGF--IGKVFVSALKAVAPVL 60
Query: 62 VFASLVVGAASISPARLGR-VGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
VF V+ ASI+ + G+ ++ ++ L F+ + ++A P + + + G+
Sbjct: 61 VF---VLVMASIANHKQGQQTHIRPILLLYLVGTFSAAVVAVIASFAFPSSLVLASHPGE 117
Query: 121 QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
P ++Q+LL + NP AL + + + +AI LGIA R ++
Sbjct: 118 MSPPGGIAEVLQSLLLSVVDNPVNALISANFIGILAWAIGLGIAF-----------RHAS 166
Query: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA 240
+T N ++ L+ + IV V+++AP+G+F L+A+ A GV+ + A + V V +G
Sbjct: 167 DTTRNLLSELSNGVSLIVKVVIRFAPLGIFGLVASTFAESGVEALKGYAHLLV-VLLGCM 225
Query: 241 LQILLVY---FVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKG 297
L + V V LK+ ++ +++ +TAF TRSS+ +PV +++ E +G+ +
Sbjct: 226 LFVAFVVNPLIVFLKIRRNPYPLVLTCLRESGMTAFFTRSSAANIPVNLQLCERLGLHED 285
Query: 298 IYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPG 357
YS ++PLGATINM G A+ V T + LG+ + + + + + A + + G +GV G
Sbjct: 286 TYSVSIPLGATINMAGAAITITVLTLAAVHTLGIAVDVPTAILLSVVASICACGASGVAG 345
Query: 358 AGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 416
+++ + G+P A A I+ I + D T +N + D+ TA + E
Sbjct: 346 GSLLLIPLACSLFGIPSEVAMQVVAVGFIIAI--LQDSAETALNSSTDVLFTAAACEAE 402
>pir||H70190 glutamate transporter (gltP) homolog - Lyme disease spirochete
>gi|2688655|gb|AAC67068.1| (AE001172) glutamate
transporter (gltP) [Borrelia burgdorferi]
Length = 463
Score = 150 bits (375), Expect = 3e-35
Identities = 99/422 (23%), Positives = 208/422 (48%), Gaps = 32/422 (7%)
Query: 14 QKILIGLILGAIVGLILGHYGYADAVKT-----YIKPFGDLFVRLLKMLVMPIVFASLVV 68
+++ I L +G + G+ + ++ ++ T +I GD +VRLLKM+++P++ S++
Sbjct: 35 KRVFIALAIGIVFGMTIQYFYGTNSEITNETINWISILGDGYVRLLKMIIIPLIITSIIS 94
Query: 69 GAASISPAR-LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAG---------ITLAEA 118
++ ++ +G++ + +++ + T+ A +GI A A + +
Sbjct: 95 AIIKLTNSKDVGKMSLLVILTLVFTAGIAAIIGIFTALALGLTAEGLQAGTIEILQSEKL 154
Query: 119 GKQFQPKQAPPLVQTLLNIIPTN---PFGALANGKVLPTIFFAIVLGIAITYLMNSKDER 175
K + + + + ++IP N F L + + F+ ++GIA K E
Sbjct: 155 QKGLEILNQTTITKKITDLIPQNIFEDFAGLRKNSTIGVVIFSAIIGIAALKTSIKKPES 214
Query: 176 VRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAV 235
+ + +L L + + +V +++ P + AL+ + A+ +K + +L + +A
Sbjct: 215 IEFFKKIILT----LQDIILGVVTLILKLTPYAILALMTKITATSEIKSIIKLGEFVIAS 270
Query: 236 YVGLALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRV-AEDMGI 294
Y+ + L L+ + L+ + ++PI FI K A+ AF++RSS+ T+P+ + + +++G+
Sbjct: 271 YIAIGLTFLM-HMTLIAINKLNPITFIKKIFPALSFAFISRSSAATIPINIEIQTKNLGV 329
Query: 295 SKGIYSFTLPLGATINMDG-TALYQGVCTFFIANALGMHLT-LGQQLTIVLTAVLASIGT 352
S+GI + + G +I +G AL+ + IA G++ T + LT++ ++ S G
Sbjct: 330 SEGIANLSSSFGTSIGQNGCAALHPAMLAIMIAPTQGINPTDISFILTLIGLIIITSFGA 389
Query: 353 AGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV 412
AG G MVL ++ P+ +++ ++ I+DMGRT VNV G + I
Sbjct: 390 AGAGGGATTASLMVLSAMNFPV------GLVGLVISVEPIIDMGRTAVNVGGSMLAGVIS 443
Query: 413 AK 414
AK
Sbjct: 444 AK 445
>pir||D81313 probable transmembrane transport protein Cj1097 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968531|emb|CAB73352.1| (AL139077) putative
transmembrane transport protein [Campylobacter jejuni]
Length = 407
Score = 148 bits (369), Expect = 1e-34
Identities = 112/418 (26%), Positives = 192/418 (45%), Gaps = 27/418 (6%)
Query: 4 LKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVF 63
++ Y + ++ +I IG+ LG ++G+ + + G LF LK + +VF
Sbjct: 6 IQSYAKGNLIVQICIGIALGILIGIS------SKEISEIANLLGILFTSALKAIAPMLVF 59
Query: 64 ASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQ 123
++ + ++ G I++ Y++ + FA ++ F + +
Sbjct: 60 ILILTSICTKDFSQSGAKIKNIIILYIVGTFFASACAVLANFFFPVKLVLDGVQTATNSS 119
Query: 124 PKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETL 183
P + + LL I NP AL++G L + +AI GIA+ + N A+ +
Sbjct: 120 PTHMSDIFKDLLFKIVDNPINALSSGNYLGILTWAIAGGIALKHCSNE--------AKQV 171
Query: 184 LNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAK-----VTVAVYVG 238
IN E + KIV V++ AP G+F L+AN +A G + + K V ++V
Sbjct: 172 FIDIN---EGVLKIVKFVVKLAPFGIFGLVANSVAQTGAQGLLSYVKLLILLVATMLFVT 228
Query: 239 LALQILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGI 298
+ L+V+F K P+ FI A AF TRSS+ +PV M + +GI K
Sbjct: 229 FVINALIVFFYTRK--NPFPLIFICLRHSAFF-AFFTRSSAANIPVNMALCAKLGIDKEF 285
Query: 299 YSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGA 358
Y ++PLGATINM G A+ + + AN +G+ ++L Q + + A A+ G +GV G
Sbjct: 286 YGISIPLGATINMAGAAVTIAILSLTAANTVGIEISLLQAFLLSIIATFAACGASGVAGG 345
Query: 359 GAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 416
+++ + + A A I+G+ I D T +N + D+ TAI +K E
Sbjct: 346 SLLLIPLACSLFNIDYDIAMKVVAIGFIIGV--IQDSVETALNSSTDVLFTAICSKNE 401
>sp|P42602|YGJU_ECOLI HYPOTHETICAL SYMPORTER YGJU >gi|7466002|pir||F65097 hypothetical
43.5 kD protein in ebgC-exuT intergenic region -
Escherichia coli (strain K-12) >gi|606028|gb|AAA57891.1|
(U18997) ORF_o414; Geneplot suggests frameshift near
start but none found [Escherichia coli]
>gi|1789473|gb|AAC76124.1| (AE000391) putative transport
protein [Escherichia coli K12]
Length = 414
Score = 147 bits (368), Expect = 2e-34
Identities = 116/421 (27%), Positives = 205/421 (48%), Gaps = 27/421 (6%)
Query: 2 GWLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPI 61
G ++ ++++IL+GL+LG ++ I + + G LFV LK V PI
Sbjct: 8 GLFRRLAHGSLVKQILVGLVLGILLAWI------SKPAAEAVGLLGTLFVGALKA-VAPI 60
Query: 62 VFASLVVGAASISPARLG-RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
+ LV+ ASI+ + G + ++ +++ L F+ L ++ P + AG
Sbjct: 61 LVLMLVM--ASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGD 118
Query: 121 QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
P +++ L+ + +NP AL G + + +AI LG A+ R
Sbjct: 119 ISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLGFAL-----------RHGN 167
Query: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLA 240
ET N +N ++ A+ +V V+++APIG+F L+++ +A+ G + A++ V V VG
Sbjct: 168 ETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLV-VLVGCM 226
Query: 241 LQILLVYFVLLKVFGI--DPIKFISKA-KDAMLTAFVTRSSSGTLPVTMRVAEDMGISKG 297
L + LV LL + I +P + +++ + AF TRSS+ +PV M + E + + +
Sbjct: 227 LLVALVVNPLLVWWKIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRD 286
Query: 298 IYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPG 357
YS ++PLGATINM G A+ V T N LG+ + L L + + A L + G +GV G
Sbjct: 287 TYSVSIPLGATINMAGAAITITVLTLAAVNTLGIPVDLPTALLLSVVASLCACGASGVAG 346
Query: 358 AGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEG 417
+++ + G+ A A I+G+ + D T +N + D+ TA + E
Sbjct: 347 GSLLLIPLACNMFGISNDIAMQVVAVGFIIGV--LQDSCETALNSSTDVLFTAAACQAED 404
Query: 418 E 418
+
Sbjct: 405 D 405
>pir||F81003 sodium/dicarboxylate symporter family protein NMB2133 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7227389|gb|AAF42441.1| (AE002561)
sodium/dicarboxylate symporter family protein [Neisseria
meningitidis MC58]
Length = 409
Score = 145 bits (363), Expect = 7e-34
Identities = 109/411 (26%), Positives = 204/411 (49%), Gaps = 41/411 (9%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
++++I GL LG ++G + G A + FG LFV LK + +VF ++ AA
Sbjct: 16 LVRQIAAGLALGIVIGSVSPQLGLAAGL------FGSLFVGALKAVAPVLVF---ILVAA 66
Query: 72 SISPARLG-RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPP- 129
+I+ + G + ++ ++ L F+ L ++A + P I LA AG APP
Sbjct: 67 TIAQHQKGNKAHIRPIIVLYLIGTFSAALTAVIAGMVFP-THIVLAGAG---DVSAAPPS 122
Query: 130 ----LVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
++++LL + NP A+AN + + +A+VLG A+ ++
Sbjct: 123 GIVEVLKSLLMNLVANPINAIANANYIGILAWALVLGAALR----------NHGSDVTRQ 172
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAV-----YVGLA 240
+ LAEA+ +V ++++AP+G+F L+++ +A G + AK+ + ++ LA
Sbjct: 173 VVADLAEAVSTVVKWIIRFAPLGIFGLVSSTIAETGFGALAGYAKLLAVLLGCMAFIALA 232
Query: 241 LQILLVYFVLLKVFGIDPIKFISKA-KDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIY 299
+ +V++ + + +P + +++ + AF TRSS+ +PV M +A+ +G+ + Y
Sbjct: 233 VNPAIVWWKIRR----NPFPLVFTCLRESGVYAFFTRSSAANIPVNMALAKKLGLHEDTY 288
Query: 300 SFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAG 359
S ++PLGATINM G A+ V A+ G+ + L + L A +++ G +GV G
Sbjct: 289 SISIPLGATINMAGAAITITVLAMAAAHTQGITVDFATALLLSLVATVSACGASGVAGGS 348
Query: 360 AIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTA 410
+++ + G+ A A I+G+ I D T +N + D+ TA
Sbjct: 349 LLLIPLACSLFGIDNDVAMQVVAVGFIIGV--IQDSAETALNSSTDVLFTA 397
>pir||B82025 probable symport protein NMA0298 [imported] - Neisseria
meningitidis (group A strain Z2491)
>gi|7379056|emb|CAB83603.1| (AL162752) putative symport
protein [Neisseria meningitidis Z2491]
Length = 409
Score = 145 bits (362), Expect = 1e-33
Identities = 113/409 (27%), Positives = 203/409 (49%), Gaps = 37/409 (9%)
Query: 12 VLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
++++I GL LG ++G + G A + FG LFV LK + +VF ++ AA
Sbjct: 16 LVRQIAAGLALGIVIGSVSPQLGLAAGL------FGSLFVGALKAVAPVLVF---ILVAA 66
Query: 72 SISPARLG-RVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPP- 129
+I+ + G + ++ ++ L F+ L ++A + P I LA AG APP
Sbjct: 67 TIAQHQKGNKAHIRPIIVLYLIGTFSAALTAVIAGMVFP-THIVLAGAG---DVSAAPPS 122
Query: 130 ----LVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLN 185
++++LL + NP A+AN + + +A+VLG A+ ++
Sbjct: 123 GIVEVLKSLLMNLVANPINAIANANYIGILAWALVLGAALR----------NHGSDVTRQ 172
Query: 186 AINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILL 245
+ LAEA+ +V ++++AP+G+F L+++ +A G + AK+ +AV +G + I L
Sbjct: 173 VVADLAEAVSTVVKWIIRFAPLGIFGLVSSTIAETGFGALAGYAKL-LAVLLGCMVFIAL 231
Query: 246 VYFVLLKVFGID----PIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSF 301
V + + I P+ F +++ + AF TRSS+ +PV M +A+ +G+ + YS
Sbjct: 232 VVNPAIVWWKIRRNPYPLVFTC-LRESGVYAFFTRSSAANIPVNMALAKKLGLHEDTYSI 290
Query: 302 TLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAI 361
++PLGAT+NM G A+ V A G+ + L + L A +++ G +GV G +
Sbjct: 291 SIPLGATVNMGGAAITITVLAMAAAYTQGIQVDFATALLLSLVATVSACGASGVAGGSLL 350
Query: 362 MLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTA 410
++ + G+ A A I+G+ I D T +N + D+ TA
Sbjct: 351 LIPLACSLFGISNDVAMQVVAVGFIIGV--IQDSAETALNSSTDVLFTA 397
>gi|11423908 solute carrier family 1 (glutamate transporter), member 7 [Homo
sapiens]
Length = 594
Score = 143 bits (356), Expect = 5e-33
Identities = 93/218 (42%), Positives = 122/218 (55%), Gaps = 16/218 (7%)
Query: 203 QYAPIGVFALIAN-VMASQGVKVVGE-LAKVTVAVYVGLALQIL----LVYFVLLKVFGI 256
+Y P G+ LIA ++ + VG+ L +V V GL L L L+YF + K
Sbjct: 345 RYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKK--- 401
Query: 257 DPIKFISKAKDAMLTAFVTRSSSGTLPVTMR-VAEDMGISKGIYSFTLPLGATINMDGTA 315
+PI FI A+L A T SSS TLP+T + + E+ I + I F LP+GATINMDGTA
Sbjct: 402 NPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTA 461
Query: 316 LYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLT 375
LY+ V FIA L GQ +TI +TA ASIG AG+P AG + + +VL SVGLP
Sbjct: 462 LYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTD 521
Query: 376 DANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVA 413
D +I+ +D LD RTM+NV GD I+A
Sbjct: 522 D------ITLIIAVDWALDRFRTMINVLGDALAAGIMA 553
Score = 72.6 bits (175), Expect = 8e-12
Identities = 46/133 (34%), Positives = 72/133 (53%), Gaps = 8/133 (6%)
Query: 16 ILIGLILGAIVGLILGHYGYADAVK----TYIKPFGDLFVRLLKMLVMPIVFASLVVGAA 71
+LI +L IVG +LG + + +Y + G+L +R+LKM+++P+V SL+ G A
Sbjct: 19 LLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRMLKMMILPLVPPSLMSGLA 78
Query: 72 SISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGI---TLAEAGKQFQPKQAP 128
S+ R+GV V YYL T+ AV +GI M I +PG+ T ++GK A
Sbjct: 79 SLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPIM-SSAD 137
Query: 129 PLVQTLLNIIPTN 141
L+ + N+ P N
Sbjct: 138 ALLDLIRNMFPAN 150
>dbj|BAA85981.1| (AB034153) unnamed protein product [Shewanella violacea]
>gi|9857268|dbj|BAB11927.1| (AB038389) ORF3 [Shewanella
violacea]
Length = 407
Score = 142 bits (354), Expect = 8e-33
Identities = 117/414 (28%), Positives = 206/414 (49%), Gaps = 42/414 (10%)
Query: 16 ILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISP 75
+L L++G +GL+ + A+K +KP G +F+ LL M+++P+V S+ A ++
Sbjct: 14 LLAALLIGGSLGLLAPEF----ALK--LKPIGQIFLNLLFMIIVPLVAISVTSSIARMTD 67
Query: 76 ARLGRVGVKIVVYYLLTSAFAV--TLGII-MARIFNPGAGITLAEAGKQFQPKQAPPLVQ 132
L ++GV +V +++ A+ L I+ +A F+P G+ L Q +A
Sbjct: 68 --LKKLGVILVTILMVSIVMAIIPALSIVGLALAFDPAQGVIL----DLNQSIEAGSGTM 121
Query: 133 TLLNIIPTNPF-GALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLA 191
+ ++ TN F G L+ +L I +++ GIAI S ++ V+ S +L+++N +
Sbjct: 122 DFVGLLTTNDFVGLLSKSNILALIIMSVISGIAIG---QSGEDGVKVSR--MLDSLNTV- 175
Query: 192 EAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVLL 251
+ KI++ +M AP+G+ A A+ MASQ ++G A+ +GL + YF L
Sbjct: 176 --IMKIISILMVAAPVGLGAYFASTMASQDTHLLGTFARA-----IGLFFIAAITYFTLG 228
Query: 252 KVF------GIDPIK-FISKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLP 304
F G+ ++ F A + +TA T SS TLPV +R A MGI + I LP
Sbjct: 229 STFYAWLGGGVKGVRQFWKHAIEPSVTALGTSSSLATLPVNIRAANKMGIKEEIADICLP 288
Query: 305 LGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLA 364
L +N G ++ + FI + LG+ T +L +VL++ GVPG +
Sbjct: 289 LLVNLNKGGASMTTALKIVFIYSLLGLEFTPDVFAITILISVLSAFVIGGVPGGAFLGEI 348
Query: 365 MVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGE 418
++ ++GLP+ +++ I A+ D T++NV DL T I+ + G+
Sbjct: 349 FIVTTLGLPI------EVIPILVIIGAVTDAPATLINVIHDLNATQIIERINGK 396
>sp|P45246|YGJU_HAEIN HYPOTHETICAL SYMPORTER HI1545 >gi|1073914|pir||H64128 hypothetical
protein HI1545 - Haemophilus influenzae (strain Rd KW20)
>gi|1574390|gb|AAC23195.1| (U32830) sodium:dicarboxylate
symporter protein [Haemophilus influenzae Rd]
Length = 414
Score = 138 bits (344), Expect = 1e-31
Identities = 108/412 (26%), Positives = 200/412 (48%), Gaps = 25/412 (6%)
Query: 12 VLQKILIGLILGAIVGLILGHY----GYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLV 67
++++I GL+LG +V LI G+ A K + G +FV+ L+ V PI+ LV
Sbjct: 15 LVKRIAAGLVLGIVVALISAPLQETIGFNLAEKVGV--LGTIFVKALRA-VAPILIFFLV 71
Query: 68 VGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQA 127
+ A + +I+V YLL + A + +I F P + A+ P+
Sbjct: 72 MAALANRKIGTKSNMKEIIVLYLLGTFLAAFVAVIAGFAF-PTEVVLAAKEDSSSAPQAV 130
Query: 128 PPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAI 187
++ TL+ + +P A+ + + ++I LG+A+ R +++ N +
Sbjct: 131 GQVLLTLILNVVDDPLNAIFKANFIGVLAWSIGLGLAL-----------RHASDATKNVL 179
Query: 188 NGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVY 247
+ AE + KIV ++ +AP GVF L+A ++ +G+ +G ++ +AV +G L V
Sbjct: 180 SDFAEGVSKIVHVIISFAPFGVFGLVAETLSDKGLVALGGYVQL-LAVLIGTMLFTAFVV 238
Query: 248 FVLLKVFGI--DPIKFI-SKAKDAMLTAFVTRSSSGTLPVTMRVAEDMGISKGIYSFTLP 304
+L + I +P + + +++ +TAF TRSS+ +PV + +A+ + + + YS ++P
Sbjct: 239 NPILVYWKIRRNPYPLVWTCVRESGVTAFFTRSSAANIPVNIELAKRLNLDEETYSVSIP 298
Query: 305 LGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLA 364
LGA INM G A+ + T + LG+ ++ L + + A L + G +GV G +++
Sbjct: 299 LGANINMAGAAITITILTLAAVHTLGLEVSFVSALLLSIVAALCACGASGVAGGSLLLIP 358
Query: 365 MVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 416
+ G+ A I+GI + D T +N + D+ TA V E
Sbjct: 359 LACSLFGISDDVAAQMIGVGFIIGI--LQDSTETALNSSTDVLFTAAVCMEE 408
>pir||B82509 sodium/dicarboxylate symporter VCA0036 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657417|gb|AAF95950.1|
(AE004347) sodium/dicarboxylate symporter [Vibrio
cholerae]
Length = 405
Score = 137 bits (342), Expect = 2e-31
Identities = 107/424 (25%), Positives = 203/424 (47%), Gaps = 35/424 (8%)
Query: 3 WLKKYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIV 62
+L + + ++ +IL G++LGA + Y + G+LFV LK + +V
Sbjct: 6 FLARLVRGNLVLQILAGILLGAAMATFSPEYAQKVGL------IGNLFVGALKAVAPVLV 59
Query: 63 FASLVVGAASISPARLGRVGVK--IVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGK 120
F ++ A+SI+ + + IVV YL + A +I++ +F P + A
Sbjct: 60 F---ILVASSIANQKKNQHTYMRPIVVLYLFGTFSAALTAVILSFLF-PTTLVLATGAEG 115
Query: 121 QFQPKQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSA 180
P+ ++ TLL + NP AL N + + + + LG+A+ + S+
Sbjct: 116 ATPPQGIAEVLNTLLFKLVDNPVSALMNANYIGILAWGVGLGLALHH-----------SS 164
Query: 181 ETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAV----- 235
T L+ + +IV +++ AP G+F L+A+ A+ G + A++ +
Sbjct: 165 STTKAVFEDLSHGISQIVRFIIRLAPFGIFGLVASTFATTGFDALAGYAQLLAVLLGAMA 224
Query: 236 YVGLALQILLVYFVLLKVFGIDPIKFISKA-KDAMLTAFVTRSSSGTLPVTMRVAEDMGI 294
++ L + ++VY+ + + +P + + +++ +TAF TRSS+ +PV M + E + +
Sbjct: 225 FIALVVNPMIVYYKIRR----NPFPLVLQCLRESGVTAFFTRSSAANIPVNMALCEKLKL 280
Query: 295 SKGIYSFTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAG 354
+ YS ++PLGATINM G A+ V T + +G+ + L L + + A +++ G +G
Sbjct: 281 DEDTYSVSIPLGATINMAGAAITITVLTLAAVHTMGIEVDLMTALLLSVVAAVSACGASG 340
Query: 355 VPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
V G +++ + G+ A A I+G+ I D T +N + D+ TA V +
Sbjct: 341 VAGGSLLLIPLACGLFGISNDIAMQVVAVGFIIGV--IQDSAETALNSSTDVLFTAAVCQ 398
Query: 415 TEGE 418
E E
Sbjct: 399 AEHE 402
>pir||E72095 neutral amino acid (glutamate) transporter - Chlamydophila
pneumoniae (strain CWL029) >gi|4376564|gb|AAD18438.1|
(AE001614) Neutral Amino Acid (Glutamate) Transporter
[Chlamydophila pneumoniae CWL029]
Length = 395
Score = 129 bits (322), Expect = 5e-29
Identities = 107/390 (27%), Positives = 186/390 (47%), Gaps = 21/390 (5%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPAR-L 78
L+L +VGL LG V + + + F++ L++L +P+VF +L SI +
Sbjct: 15 LLLSILVGLGLGSVQSPWIVYS-AECIANTFLKFLRLLSIPLVFCALGSTITSIQNFNTM 73
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPPL--VQTLLN 136
+G +I+ Y LLT+ A ++G+++ + P A A + PL + L +
Sbjct: 74 VTLGKRILYYTLLTTVIAASIGLLLFFLLRPQMITQDALA----TTTKCNPLGYLDVLSD 129
Query: 137 IIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYK 196
+P N F G V+ A++LG A +L + V + + + LA K
Sbjct: 130 TLPENIFKPFLQGNVISAACLAVLLGTASLFLQEKEKHFVNQFFNSFFSIFLNLARGGLK 189
Query: 197 IVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVLLKVFGI 256
+ + A +G ++ + Q + A+ + V Q +V +LLK+ +
Sbjct: 190 L----LPIAMLGFSVILFKELKDQSNLTM--FAEYLLCVIGANLAQGFIVLPILLKINKV 243
Query: 257 DPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGATINMDGTA 315
P+K A++TAF ++SS+ TLP+TM +AED + I+K + F+ PL + INM+G A
Sbjct: 244 SPLKVAKAMSPALVTAFFSKSSAATLPLTMELAEDDLKINKNLSRFSFPLCSVINMNGCA 303
Query: 316 LYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLT 375
+ + F+A + GM ++ L + A LA+IG AGVP + +L S+ +PL
Sbjct: 304 AFILITVLFVATSNGMIISPLMSLGWIFIATLAAIGNAGVPMGCYFLTLSLLTSMNVPL- 362
Query: 376 DANVAAAYAMILGIDAILDMGRTMVNVTGD 405
+ +IL ++DM T +NV D
Sbjct: 363 -----SILGLILPFYTVIDMIETSLNVWSD 387
>gb|AAF73673.1| (AE002208) sodium:dicarboxylate symporter family protein
[Chlamydophila pneumoniae AR39]
>gi|8978663|dbj|BAA98499.1| (AP002546) neutral amino
acid (glutamate) transporter [Chlamydophila pneumoniae
J138]
Length = 395
Score = 129 bits (322), Expect = 5e-29
Identities = 107/390 (27%), Positives = 186/390 (47%), Gaps = 21/390 (5%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPAR-L 78
L+L +VGL LG V + + + F++ L++L +P+VF +L SI +
Sbjct: 15 LLLSILVGLGLGSVQSPWIVYS-AECIANTFLKFLRLLSIPLVFCALGSTITSIQNFNTM 73
Query: 79 GRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPPL--VQTLLN 136
+G +I+ Y LLT+ A ++G+++ + P A A + PL + L +
Sbjct: 74 VTLGKRILYYTLLTTVIAASIGLLLFFLLRPQMITQDALA----TTTKCNPLGYLDVLSD 129
Query: 137 IIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYK 196
+P N F G V+ A++LG A +L + V + + + LA K
Sbjct: 130 TLPENIFKPFLQGNVISAACLAVLLGTASLFLQEKEKHFVNQFFNSFFSIFLNLARGGLK 189
Query: 197 IVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVLLKVFGI 256
+ + A +G ++ + Q + A+ + V Q +V +LLK+ +
Sbjct: 190 L----LPIAMLGFSVILFKELKDQSNLTM--FAEYLLCVIGANLAQGFIVLPILLKINKV 243
Query: 257 DPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGATINMDGTA 315
P+K A++TAF ++SS+ TLP+TM +AED + I+K + F+ PL + INM+G A
Sbjct: 244 SPLKVAKAMSPALVTAFFSKSSAATLPLTMELAEDDLKINKNLSRFSFPLCSVINMNGCA 303
Query: 316 LYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLT 375
+ + F+A + GM ++ L + A LA+IG AGVP + +L S+ +PL
Sbjct: 304 AFILITVLFVATSNGMIISPLMSLGWIFIATLAAIGNAGVPMGCYFLTLSLLTSMNVPL- 362
Query: 376 DANVAAAYAMILGIDAILDMGRTMVNVTGD 405
+ +IL ++DM T +NV D
Sbjct: 363 -----SILGLILPFYTVIDMIETSLNVWSD 387
>pir||T34005 hypothetical protein W03G1.1 - Caenorhabditis elegans
>gi|4262633|gb|AAD14749.1| (AF125964) similar to the
sodium:dicarboxylate symporter family [Caenorhabditis
elegans]
Length = 507
Score = 129 bits (320), Expect = 8e-29
Identities = 110/430 (25%), Positives = 196/430 (45%), Gaps = 58/430 (13%)
Query: 9 EFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVV 68
E +L LI + +G G++L + +D + + G++F+++LK++V+P++F+SL+
Sbjct: 8 ESQLLVFTLIAVGIGFASGILLRQFDLSDNARNLVGFPGEIFMQVLKLMVLPLIFSSLIS 67
Query: 69 GAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQ-- 126
+ +R G++ + YYL T A +G+ M +F+PG + + ++
Sbjct: 68 SLGQMDASRSGKMSFIAIAYYLTTVIIASCIGVAMVFLFHPGDPDMRSHRPEDVVIREDN 127
Query: 127 ----APPLVQTLLNIIPTN-----------PFGALANGKVLPTIFF--AIVLGIAITYLM 169
++ + N+ P N F + +PTIFF IV ++
Sbjct: 128 NISALDSILDLIRNMFPQNIVEATMYRSQTAFVVVGLRTYMPTIFFPGLIVFCTGFGIVI 187
Query: 170 NSKDERVRKSAETLLNAINGLAEAMYKIVAGVMQYAPIGVFALIANVM--ASQGVKVVGE 227
+ +VR E + L + + K ++ +M +AP G+ +LIA+ + K+V
Sbjct: 188 SKLGGKVRVIVEFFI----VLDKVVMKFISVLMLFAPFGIVSLIASSVLDIDDLYKMVTT 243
Query: 228 LAKVTVAVYVGLALQILL----VYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLP 283
+A + L L ++ +YF + K ID K + + +TA T SS +LP
Sbjct: 244 MALYVFTIMCSLFLHCVIAVPTLYFFITKKSPIDVAKGMVQ---PFVTAIGTASSGASLP 300
Query: 284 VTMRVAEDMGISKGIYSFTLPLGATINM-DGTALYQGVCTFFIANALGMHLTLGQQLTIV 342
M E+ N+ DG ALY+ V F+A + L+ +TI
Sbjct: 301 QAMSSVEE------------------NLHDGNALYEAVAVIFVAQLNNVTLSFADVITIC 342
Query: 343 LTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNV 402
+TA ASIG VP AG + + ++L SV LP++D A++ +D +D RT +NV
Sbjct: 343 VTATFASIGLNAVP-AGLVSMFVILSSVNLPVSD------IALLFTVDWFIDRVRTALNV 395
Query: 403 TGDLTGTAIV 412
GD +V
Sbjct: 396 LGDAYCACVV 405
>gb|AAF73565.1| (AE002318) sodium:dicarboxylate symporter family protein [Chlamydia
muridarum]
Length = 415
Score = 120 bits (299), Expect = 2e-26
Identities = 107/407 (26%), Positives = 184/407 (44%), Gaps = 23/407 (5%)
Query: 20 LILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLG 79
L L ++GLILG + + + + F++LLK+L +P+VF ++ SI+ R
Sbjct: 18 LSLSILLGLILG-WPHLPFISFSAEIVSAAFLKLLKLLSLPLVFFAIGSTITSINDLRSM 76
Query: 80 RVGVKIVVYY-LLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPPLVQTLLNII 138
V+ +YY LLT+ + + + + + P +T + + L I
Sbjct: 77 IAVVRASLYYTLLTTIISAGIALALFILIKPSVNLTGLNLNVG---ANSTGYLAVLSKTI 133
Query: 139 PTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMYKIV 198
P N V+ F + +L L ++ER+ + NA N L + I
Sbjct: 134 PGNILEPFLESNVIAAAFLSFLLSFFSLSL--PEEERL-----FIRNAFNTLFSLLLNIA 186
Query: 199 AGVMQYAPIGVFA---LIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVLLKVFG 255
G+++ P+ F+ L M + +++ + LQ ++ +LLK+ G
Sbjct: 187 KGILKMLPLATFSFSLLFVREMRTGSLEL-SSFGGYLFCIVGANCLQGFVILPLLLKIKG 245
Query: 256 IDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGATINMDGT 314
I PI+ + TAF ++SS+ TLP+TM VAE+ + I I F PL + INM+
Sbjct: 246 ISPIRTFRLMSRPLATAFFSKSSAATLPLTMEVAEENLHIQPTISRFVFPLCSVINMNAC 305
Query: 315 ALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPL 374
A + + FI + G+ + ++ V A LA++G AGVP + + +L S+ +PL
Sbjct: 306 AAFILITVLFIGVSNGVVFSPLSLISWVFIATLAAVGNAGVPMGCYFLASSLLSSMNIPL 365
Query: 375 TDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELKE 421
+IL A+LDM T++NV D +I+ K KE
Sbjct: 366 ------GLLGLILPAYALLDMLETLINVWSDCCVVSIINKKFTNTKE 406
>pir||B71541 probable amino acid (glutamate) transporter - Chlamydia trachomatis
(serotype D, strain UW3/Cx) >gi|3328639|gb|AAC67822.1|
(AE001296) Neutral Amino Acid (Glutamate) Transporter
[Chlamydia trachomatis]
Length = 415
Score = 120 bits (297), Expect = 4e-26
Identities = 107/421 (25%), Positives = 192/421 (45%), Gaps = 25/421 (5%)
Query: 6 KYLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFAS 65
K L P +++GL + ++GL+LG + + V + +F++LL++L +P+VF +
Sbjct: 6 KLLFSPEKSNMMLGLSI--LLGLLLG-WPHLSFVSLSAEVISAVFLKLLRLLSLPLVFFA 62
Query: 66 LVVGAASISPARLGRVGVKIVVYY-LLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQP 124
+ SI+ + V+ +YY LLT+ + + +++ P ++ A +
Sbjct: 63 IGSTITSINNLKSMVSVVRSSLYYTLLTTLISAAMALVLFIFIKPSVPLSGFNAATE--- 119
Query: 125 KQAPPLVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLL 184
A + L IP N V+ F + +L L ++ VR
Sbjct: 120 TNATGYLSVLSKTIPGNILEPFLESNVIAAAFLSALLATFSLSLPENERLFVR------- 172
Query: 185 NAINGLAEAMYKIVAGVMQYAPIGVFA---LIANVMASQGVKVVGELAKVTVAVYVGLAL 241
NA N L + I G+++ + FA L M + +++ + + L
Sbjct: 173 NAFNTLFSLLLSISKGILKMLLLATFAFSLLFVREMRTGNLEL-SSFGEYLFCIVTANCL 231
Query: 242 QILLVYFVLLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYS 300
Q LV +LLK+ GI P++ + TAF ++SS+ TLP+TM VAE+ + I I
Sbjct: 232 QGFLVLPLLLKMKGISPLRTFKLMSRPLATAFFSKSSAATLPLTMEVAEENLHIRPTISR 291
Query: 301 FTLPLGATINMDGTALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGA 360
F PL + INM+ A + F+ + G+ + ++ V A LA++G AGVP
Sbjct: 292 FVFPLCSVINMNACAAFILTTVLFVGVSNGIVFSPLSLISWVFIATLAAVGNAGVPMGCY 351
Query: 361 IMLAMVLESVGLPLTDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGELK 420
+ + +L S+ +PL +IL A+LDM T++NV D +++ K E +
Sbjct: 352 FLTSSLLASMNVPL------CLLGLILPAYALLDMLETLINVWSDCCVVSVINKKFSETE 405
Query: 421 E 421
+
Sbjct: 406 D 406
>gb|AAC46376.1| (AF017105) amino acid transporter [Chlamydophila caviae]
Length = 406
Score = 119 bits (296), Expect = 5e-26
Identities = 101/400 (25%), Positives = 187/400 (46%), Gaps = 21/400 (5%)
Query: 20 LILGAI-VGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVGAASISPAR- 77
L+LG++ +GL L + + + + +F++LL+ L +P+VF ++ SI +
Sbjct: 13 LLLGSMFIGLALASFN-SPLIFQSAEIISGIFLKLLRFLSLPLVFFAIGSTITSIKNFQT 71
Query: 78 LGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQ--APPLVQTLL 135
+ +G KI+ Y LLT+ + T+G+ + I P + G P + ++ L
Sbjct: 72 MLSLGRKILYYTLLTTVISATVGLGLFIIIYPAMPLE----GSLETPATTCSTGYLKVLS 127
Query: 136 NIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAINGLAEAMY 195
+ IP N + V+ F A++LGIA +L + T + + +A+ +
Sbjct: 128 DTIPGNILEPFIDNNVISATFLAVILGIASLFLPEKEKNLTHNLFSTFFSILLNIAKGVL 187
Query: 196 KIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFVLLKVFG 255
K++ F+++ A+Q + +K + V +Q L+V LLK
Sbjct: 188 KLLVPATL-----AFSILFYKEATQNQGNLVIFSKYLLCVVGANLIQGLIVLPWLLKANK 242
Query: 256 IDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVAED-MGISKGIYSFTLPLGATINMDGT 314
+ P+ + A++TAF ++SS+ TLP+TM +AE+ + I + PL + INM+G
Sbjct: 243 LSPLNIAKRMSPALITAFFSKSSASTLPLTMELAEEELKIKPSLSRLAFPLCSVINMNGC 302
Query: 315 ALYQGVCTFFIANALGMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPL 374
A + + F+ + G+ +L + V A L ++G AGVP + + ++ S+ +PL
Sbjct: 303 AAFILITVLFLGISNGISFSLFSMIGWVFIATLCAVGNAGVPMGCFFLASSLITSMHIPL 362
Query: 375 TDANVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK 414
+IL ILDM T +NV D ++ K
Sbjct: 363 ------HLLGLILPFYTILDMIETSLNVWSDCCVVSLTDK 396
>pir||G71309 probable glutamate/ aspartate transporter - syphilis spirochete
>gi|3322849|gb|AAC26559.1| (AE001231) glutamate/
aspartate transporter, putative [Treponema pallidum]
Length = 396
Score = 80.4 bits (195), Expect = 4e-14
Identities = 96/399 (24%), Positives = 167/399 (41%), Gaps = 36/399 (9%)
Query: 10 FPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASLVVG 69
F +L K+ G++ G +GL + ++V I G + + V+P+V +
Sbjct: 7 FWLLAKLSGGMVCGVALGLCVN-----ESVMAIIHT-GKTLIGGVVFFVIPLVIFGFIAP 60
Query: 70 AASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAEAGKQFQPKQAPP 129
A GR+ +V L+S A M R+ P I G + PK
Sbjct: 61 TVLSLKASAGRMLGSFLVLSYLSSVGASLFATAMGRVVIPYLRIPRTVEGLRTIPK---- 116
Query: 130 LVQTLLNIIPTNPFGALANGKVLPTIFFAIVLGIAITYLMNSKDERVRKSAETLLNAING 189
V L I P V+ + FA+++G++ ++ + R + L
Sbjct: 117 -VIFTLEIPSLMP--------VVTALAFALLVGLSALWV------KARAVEQVLYEFRRM 161
Query: 190 LAEAMYKIVAGVMQYAPIGVFALIANVMASQGVKVVGELAKVTVAVYVGLALQILLVYFV 249
+ EA+ +++ ++ + FA +A + + + AKV V VG L + ++Y V
Sbjct: 162 MGEAISRVLVPLLPFFVAATFAELA--YSGSLTRQLPLFAKVVAVVIVGHLLWLCVLYLV 219
Query: 250 LLKVFGIDPIKFISKAKDAMLTAFVTRSSSGTLPVTMRVA-EDMGISKGIYSFTLPLGAT 308
+ +P + + A TA T SS+ TLPV+++ A + + I F +PLGAT
Sbjct: 220 GWILSRKNPFEVLRHYGAAYATALGTMSSAATLPVSLQCAHKSRALPAEIVDFAIPLGAT 279
Query: 309 INMDGTALYQGVCTFFIANAL-GMHLTLGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVL 367
++ G+ L + IA L G +L + + ++G GVPG VL
Sbjct: 280 THLCGSVLTETFFCLTIAQMLYGSMPSLADMVLFSCLFGIFAVGAPGVPG------GTVL 333
Query: 368 ESVGLPLTDANV-AAAYAMILGIDAILDMGRTMVNVTGD 405
S+GL L + +++ I A+ D T N+TGD
Sbjct: 334 ASLGLVLDVLHFDTTGTGLLIAIFALQDSFGTACNITGD 372
>gb|AAB71742.1| (U75217) glutamate transporter mEAAC1 [Mus musculus]
Length = 182
Score = 71.8 bits (173), Expect = 1e-11
Identities = 36/138 (26%), Positives = 75/138 (54%), Gaps = 6/138 (4%)
Query: 7 YLEFPVLQKILIGLILGAIVGLILGHYGYADAVKTYIKPFGDLFVRLLKMLVMPIVFASL 66
+L + +++G++LG +V GH ++ K Y G++ +R+LK++++P++ +S+
Sbjct: 19 WLLLSTVAAVVLGIVLGVVVR---GHSELSNLDKFYFAFPGEILMRMLKLVILPLIVSSM 75
Query: 67 VVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARIFNPGAGITLAE---AGKQFQ 123
+ G A++ G++G++ VVYY T+ AV LGI++ PG + + GK +
Sbjct: 76 ITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVAQKVNDINRTGKTPE 135
Query: 124 PKQAPPLVQTLLNIIPTN 141
++ + N+ P N
Sbjct: 136 VSTMDAMLDLIRNMFPEN 153
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.325 0.142 0.396
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 135805628
Number of Sequences: 2977
Number of extensions: 5364179
Number of successful extensions: 20967
Number of sequences better than 1.0e-10: 160
Number of HSP's better than 0.0 without gapping: 135
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 20130
Number of HSP's gapped (non-prelim): 259
length of query: 425
length of database: 189,106,746
effective HSP length: 57
effective length of query: 368
effective length of database: 154,992,987
effective search space: 57037419216
effective search space used: 57037419216
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.6 bits)
S2: 166 (69.1 bits)