BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1800 (mcmA1) DE:methylmalonyl-CoA mutase, subunit alpha,
N-terminus (mcmA1)
(562 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||C75130 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [simi... 1133 0.0
pir||B71001 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [simi... 1113 0.0
gi|11499797 methylmalonyl-CoA mutase, subunit alpha, N-terminus ... 823 0.0
gi|11500022 Methylmalonyl-CoA mutase, N-terminal domain/subunit ... 718 0.0
gb|AAK42569.1| Methylmalonyl-CoA mutase, alpha-subunit, chain A ... 695 0.0
pir||C72550 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [simi... 692 0.0
gb|AAG19017.1| (AE005001) methylmalonyl-CoA mutase, subunit alph... 685 0.0
emb|CAB71920.1| (AL138668) methylmalonyll-CoA mutase. [Streptomy... 660 0.0
emb|CAC11604.1| (AL445064) probable methylmalonyl-CoA mutase, al... 658 0.0
emb|CAC17657.1| (AL450450) methylmalonyl CoA mutase [Streptomyce... 651 0.0
pir||D75425 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [simi... 598 e-170
gb|AAG19151.1| (AE005013) methylmalonyl-CoA mutase, subunit alph... 591 e-168
pir||S13043 methylmalonyl-CoA mutase (EC 5.4.99.2) - mouse 551 e-156
gi|4557767 methylmalonyl Coenzyme A mutase precursor [Homo sapie... 547 e-154
gi|6678970 methylmalonyl-Coenzyme A mutase [Mus musculus] >gi|12... 544 e-154
pir||T46549 isobutyryl-CoA mutase (EC 5.4.99.13) chain A [valida... 543 e-153
emb|CAC17595.1| (AJ300476) methylmalonyl-CoA mutase [Bos taurus] 542 e-153
pir||F75440 methylmalonyl-CoA mutase, beta subunit - Deinococcus... 538 e-152
gb|AAA99226.1| (M37510) methylmalonyl-CoA mutase [Homo sapiens] 536 e-151
sp|O86028|MUTB_RHIME METHYLMALONYL-COA MUTASE (MCM) >gi|3549312|... 536 e-151
sp|Q23381|MUTA_CAEEL PROBABLE METHYLMALONYL-COA MUTASE, MITOCHON... 535 e-151
sp|Q05065|MUTB_STRCM METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM... 534 e-151
pir||D65076 sbm protein - Escherichia coli >gi|882446|gb|AAA6908... 533 e-150
dbj|BAB06674.1| (AP001517) methylmalonyl-CoA mutase alpha subuni... 533 e-150
sp|P27253|SBM_ECOLI SBM PROTEIN >gi|96094|pir||S22099 sbm protei... 532 e-150
pir||T43706 isobutyryl-CoA mutase (EC 5.4.99.13) chain A [simila... 531 e-150
pir||S40622 methylmalonyl CoA mutase precursor - human 528 e-149
sp|P11653|MUTB_PROFR METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM... 511 e-144
pdb|6REQ|A Chain A, Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Co... 511 e-144
pdb|5REQ|A Chain A, Methylmalonyl-Coa Mutase, Y89f Mutant, Subst... 510 e-143
pdb|1E1C|A Chain A, Methylmalonyl-Coa Mutase H244a Mutant >gi|85... 507 e-142
sp|Q59677|MUTA_PORGI METHYLMALONYL-COA MUTASE BETA-SUBUNIT (MCB-... 500 e-140
sp|P71774|MUTB_MYCTU PROBABLE METHYLMALONYL-COA MUTASE LARGE SUB... 500 e-140
pir||T35959 methylmalonyl-CoA mutase, coenzyme B12-dependent - S... 397 e-109
gb|AAC45598.1| (AF008569) coenzyme B12-dependent mutase [Strepto... 391 e-107
sp|Q49115|MEAA_METEX MEAA PROTEIN >gi|1098584|gb|AAC44087.1| (U2... 384 e-105
dbj|BAB07515.1| (AP001520) unknown [Bacillus halodurans] 312 5e-84
gb|AAD53916.1|AF178673_2 (AF178673) MeaA [Streptomyces cinnamone... 215 1e-54
dbj|BAB06675.1| (AP001517) methylmalonyl-CoA mutase beta subunit... 181 2e-44
sp|Q05064|MUTA_STRCM METHYLMALONYL-COA MUTASE SMALL SUBUNIT (MCM... 177 3e-43
pdb|1E1C|B Chain B, Methylmalonyl-Coa Mutase H244a Mutant >gi|85... 148 1e-34
sp|P11652|MUTA_PROFR METHYLMALONYL-COA MUTASE SMALL SUBUNIT (MCB... 147 3e-34
sp|Q59676|MUTB_PORGI METHYLMALONYL-COA MUTASE ALPHA-SUBUNIT (MCM... 144 2e-33
sp|P71773|MUTA_MYCTU PROBABLE METHYLMALONYL-COA MUTASE SMALL SUB... 118 1e-25
gb|AAB31158.1| methylmalonyl CoA mutase, MCM {EC 5.4.99.2} [huma... 77 4e-13
>pir||C75130 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [similarity] -
Pyrococcus abyssi (strain Orsay)
>gi|5458267|emb|CAB49756.1| (AJ248285) methylmalonyl-CoA
mutase, subunit alpha, N-terminus (mcmA1) [Pyrococcus
abyssi]
Length = 562
Score = 1133 bits (2899), Expect = 0.0
Identities = 562/562 (100%), Positives = 562/562 (100%)
Query: 1 MTFDVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDY 60
MTFDVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDY
Sbjct: 1 MTFDVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDY 60
Query: 61 LEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD 120
LEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD
Sbjct: 61 LEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD 120
Query: 121 LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMY 180
LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMY
Sbjct: 121 LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMY 180
Query: 181 ILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI 240
ILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI
Sbjct: 181 ILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI 240
Query: 241 SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI 300
SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI
Sbjct: 241 SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI 300
Query: 301 AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVL 360
AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVL
Sbjct: 301 AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVL 360
Query: 361 GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIF 420
GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIF
Sbjct: 361 GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIF 420
Query: 421 EEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIE 480
EEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIE
Sbjct: 421 EEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIE 480
Query: 481 VEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLA 540
VEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLA
Sbjct: 481 VEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLA 540
Query: 541 TLQEVTDVLREIWGEYRAPLIF 562
TLQEVTDVLREIWGEYRAPLIF
Sbjct: 541 TLQEVTDVLREIWGEYRAPLIF 562
>pir||B71001 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [similarity] -
Pyrococcus horikoshii >gi|3257727|dbj|BAA30410.1|
(AP000006) 563aa long hypothetical methylmalonyl-CoA
mutase [Pyrococcus horikoshii]
Length = 563
Score = 1113 bits (2846), Expect = 0.0
Identities = 550/562 (97%), Positives = 558/562 (98%)
Query: 1 MTFDVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDY 60
MTFD E LKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGE+W+Y
Sbjct: 2 MTFDKEVLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGEDWNY 61
Query: 61 LEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD 120
+EKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD
Sbjct: 62 MEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD 121
Query: 121 LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMY 180
LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTIN+TAANLLAMY
Sbjct: 122 LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINSTAANLLAMY 181
Query: 181 ILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI 240
ILVAEEQGV QEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI
Sbjct: 182 ILVAEEQGVSQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI 241
Query: 241 SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI 300
SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI
Sbjct: 242 SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI 301
Query: 301 AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVL 360
AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNI+RVAIQALAAVL
Sbjct: 302 AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVL 361
Query: 361 GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIF 420
GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHI+
Sbjct: 362 GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIY 421
Query: 421 EEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIE 480
EEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVN FVTDEPIE
Sbjct: 422 EEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNAFVTDEPIE 481
Query: 481 VEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLA 540
VEILKVDPSIR+KQIERLKKLRSERDNKKV+EALDKLRNAAEKEDENLMPYIIEAHRHLA
Sbjct: 482 VEILKVDPSIREKQIERLKKLRSERDNKKVQEALDKLRNAAEKEDENLMPYIIEAHRHLA 541
Query: 541 TLQEVTDVLREIWGEYRAPLIF 562
TLQEVTDVLREIWGEYRAPLIF
Sbjct: 542 TLQEVTDVLREIWGEYRAPLIF 563
>gi|11499797 methylmalonyl-CoA mutase, subunit alpha, N-terminus (mcmA1)
[Archaeoglobus fulgidus] >gi|7483870|pir||G69526
methylmalonyl-CoA mutase (EC 5.4.99.2) chain A
[similarity] - Archaeoglobus fulgidus
>gi|2648308|gb|AAB89037.1| (AE000952) methylmalonyl-CoA
mutase, subunit alpha, N-terminus (mcmA1) [Archaeoglobus
fulgidus]
Length = 548
Score = 823 bits (2104), Expect = 0.0
Identities = 401/548 (73%), Positives = 471/548 (85%), Gaps = 2/548 (0%)
Query: 15 EKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTR 74
+K WEE VK LE++PERK++F T G + R+YTP D+ DY KLG+PG YPFTR
Sbjct: 3 KKEWEEKYVKPLLERSPERKKEFKTSSGIVVDRLYTPEDV--EIDYENKLGYPGVYPFTR 60
Query: 75 GVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLA 134
GVY TMYRGR+WTMRQYAG+ TAEE+N+RY+YLL QGQTGLSVAFDLPTQ+GYDSDHP+A
Sbjct: 61 GVYPTMYRGRLWTMRQYAGFGTAEETNRRYRYLLEQGQTGLSVAFDLPTQIGYDSDHPMA 120
Query: 135 EGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKL 194
GEVGKVGVAID++ DM ILF+GIPL KVSTSMTIN+T A +L+MY+ VAE+QGV + L
Sbjct: 121 LGEVGKVGVAIDTIEDMEILFNGIPLGKVSTSMTINSTCAQILSMYVAVAEKQGVERANL 180
Query: 195 RGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANA 254
RGTVQND+LKEYIARGTYIFPP+PS+RL TDIIM+CA+ +PKWN ISISGYH+ EAGA
Sbjct: 181 RGTVQNDMLKEYIARGTYIFPPEPSLRLATDIIMFCAKEMPKWNSISISGYHMEEAGATP 240
Query: 255 VQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIM 314
VQEVAFTLADGI YV+ VIERGMDVD FAPRLSFFFAA NNFLEEIAKFRAARRLWA IM
Sbjct: 241 VQEVAFTLADGITYVEKVIERGMDVDSFAPRLSFFFAAGNNFLEEIAKFRAARRLWARIM 300
Query: 315 KEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEA 374
KE FNAKNPRSMMLRFH QTAG TLTAQQPENNI+RVA+QALAAVLGG QSLHTNS+DEA
Sbjct: 301 KERFNAKNPRSMMLRFHVQTAGCTLTAQQPENNIVRVALQALAAVLGGCQSLHTNSFDEA 360
Query: 375 LSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMG 434
L LPTEK+VRIALRTQQIIA ESGV D VDPLGG+YYIEWLTD I EEA+KYIEKI +MG
Sbjct: 361 LCLPTEKAVRIALRTQQIIAEESGVADVVDPLGGSYYIEWLTDRIEEEAMKYIEKIDEMG 420
Query: 435 GMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVDPSIRDKQ 494
GM++AIE GYVQ+EI ++AY+ QK I+EG+ +VGVNK+ +E I++E+L+VD ++ +KQ
Sbjct: 421 GMIKAIESGYVQREIQKSAYEKQKAIDEGEITVVGVNKYQIEEEIQIELLRVDKAVVEKQ 480
Query: 495 IERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWG 554
I RL++ R RD KKVEEALD+LR AAEKEDENLMPY+++A + ATL E+TD LR+++G
Sbjct: 481 IRRLQEFRKNRDAKKVEEALDRLRKAAEKEDENLMPYVLDAVKARATLGEMTDALRDVFG 540
Query: 555 EYRAPLIF 562
E+RAP IF
Sbjct: 541 EFRAPEIF 548
>gi|11500022 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Archaeoglobus
fulgidus]
Length = 559
Score = 718 bits (1832), Expect = 0.0
Identities = 341/560 (60%), Positives = 455/560 (80%), Gaps = 8/560 (1%)
Query: 8 LKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFP 67
+ I E+ K WEE +K +L+KA +R+EKF T G E+ +Y P D+ E+ D++ +G+P
Sbjct: 1 MTNINEKRKEWEEKCLKPWLQKAGQREEKFETLSGIEVNTVYDPTDI-EHIDFVRDIGYP 59
Query: 68 GEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGY 127
GE+PFTRGVY MYRGR+WTMRQ++G+ TAE++N+R+K LL +G+TGLS AFD PT +G
Sbjct: 60 GEFPFTRGVYPNMYRGRLWTMRQFSGFGTAEDTNRRWKMLLEEGETGLSTAFDFPTLMGV 119
Query: 128 DSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQ 187
DSD PLA+GEVGKVGVA+D+L D ILFDGIPLDKVSTS TIN A +LAMY+ +AE+Q
Sbjct: 120 DSDDPLADGEVGKVGVAVDTLKDFEILFDGIPLDKVSTSFTINPPAGIILAMYVAIAEKQ 179
Query: 188 GVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHI 247
GVP+EK+RGT+QND+LKE+ A+ T + PP+PS+++ DI + ENVPK+N ISISGYHI
Sbjct: 180 GVPKEKIRGTIQNDMLKEFHAQNTLVLPPEPSLKIIVDIFEWGIENVPKFNLISISGYHI 239
Query: 248 REAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAAR 307
REAG+ AVQE+AFT+ADG+ YV+A +ERG+D+D+ AP+LSFFF +HN+F EEIAKFRAAR
Sbjct: 240 REAGSTAVQELAFTIADGMAYVEAAMERGIDIDRLAPQLSFFFNSHNDFFEEIAKFRAAR 299
Query: 308 RLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLH 367
R+WA IM++ + AKNPRS L+FHTQTAG +LTAQQP NNI+R IQA+AAVLGGTQSLH
Sbjct: 300 RMWAKIMRDEYGAKNPRSWWLKFHTQTAGCSLTAQQPLNNIVRTTIQAMAAVLGGTQSLH 359
Query: 368 TNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYI 427
TNS+DEA +LP+E++VR+ALRTQQIIAYESG+ + VDPL G+YY+EWLTD + + A KYI
Sbjct: 360 TNSFDEAWALPSEEAVRVALRTQQIIAYESGIPNVVDPLAGSYYVEWLTDKMEKLAWKYI 419
Query: 428 EKIQKMG------GMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEV 481
E I+KMG G+++ IE G+ +EI++AA +YQ+EIEEGKRI+VGVNKF +E +++
Sbjct: 420 EDIRKMGEGSMLRGVLKGIENGFFVREISDAAARYQREIEEGKRIVVGVNKFTIEEELKI 479
Query: 482 EILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLAT 541
ILKVDP ++ +QIERL+K+++ERDN+ V+EAL+ LRNAAE DEN+MP I+EA + AT
Sbjct: 480 PILKVDPEVQRRQIERLRKVKAERDNEAVKEALEWLRNAAE-NDENVMPPIMEAVKAYAT 538
Query: 542 LQEVTDVLREIWGEYRAPLI 561
+ E+ VL+E++G Y+ P+I
Sbjct: 539 IGEIMGVLKEVYGTYKKPII 558
>gb|AAK42569.1| Methylmalonyl-CoA mutase, alpha-subunit, chain A (mcmA1)
[Sulfolobus solfataricus]
Length = 561
Score = 695 bits (1775), Expect = 0.0
Identities = 347/553 (62%), Positives = 426/553 (76%), Gaps = 3/553 (0%)
Query: 11 IKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEY 70
+++ K WEE +++K ERK++F T G IK +YTP D+ N Y+EKLG PGEY
Sbjct: 11 VEDRIKEWEEKVYSSWVKKRGERKKEFKTFSGIHIKPVYTPLDVKGN--YMEKLGLPGEY 68
Query: 71 PFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSD 130
PFTRG+Y MYRGRIWT+RQYAG+ +AEE+N R++ LL GQTGLS+AFDLPTQLG D D
Sbjct: 69 PFTRGIYPNMYRGRIWTIRQYAGFGSAEETNSRFRKLLEAGQTGLSMAFDLPTQLGLDPD 128
Query: 131 HPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVP 190
H LA E+G VGV++ +M I+ GIPLDKV+TSMTINATA LL+M I +E + +
Sbjct: 129 HELAYTEIGVVGVSMFHWKEMDIVMSGIPLDKVTTSMTINATAMELLSMLIATSESRNIN 188
Query: 191 QEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREA 250
+ L GTVQNDILKEYIAR +I+PP PSMR DII Y A+ +PKW+PISISGYHIREA
Sbjct: 189 KSVLDGTVQNDILKEYIARKNFIYPPSPSMRYAIDIIEYSAKYLPKWHPISISGYHIREA 248
Query: 251 GANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLW 310
GA+AV EVAFTLADG+EYV+ +ERG++VD+FAP LSFFFAA+++ EE+AKFRAARR+W
Sbjct: 249 GADAVLEVAFTLADGMEYVRKTMERGINVDEFAPHLSFFFAAYSDIFEEVAKFRAARRMW 308
Query: 311 AYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNS 370
A IMKE FNAK P SMMLRFHTQT G+ LTAQQPE NIIR +QALAAVLGGTQSLH NS
Sbjct: 309 AKIMKEVFNAKKPESMMLRFHTQTGGAELTAQQPEINIIRTTLQALAAVLGGTQSLHVNS 368
Query: 371 YDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKI 430
YDEAL+LPTEK+ +IA+R QQIIA ESG D VDPLGG+YYIEWLTD I E A K I+++
Sbjct: 369 YDEALALPTEKAAKIAIRVQQIIANESGAADVVDPLGGSYYIEWLTDEIEERAWKIIDQV 428
Query: 431 QKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPI-EVEILKVDPS 489
+KMGGM++AIE GY Q +IAE+AYK QK IEEG VGVN + E I EI +V+P
Sbjct: 429 EKMGGMIKAIENGYPQAQIAESAYKIQKRIEEGDLGKVGVNMYYEPEWIGTTEIFRVNPE 488
Query: 490 IRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVL 549
+R++ I RLKK + ERD K+ E+L+ LR AEKE+ENL PY+I+A R AT+ E + VL
Sbjct: 489 VRERVISRLKKYKQERDEMKLRESLNNLRKIAEKENENLFPYMIDAIRAGATVGETSGVL 548
Query: 550 REIWGEYRAPLIF 562
R+IWGEY+ P IF
Sbjct: 549 RDIWGEYKEPSIF 561
>pir||C72550 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [similarity] -
Aeropyrum pernix (strain K1) >gi|5105375|dbj|BAA80688.1|
(AP000062) 565aa long hypothetical methylmalonyl-CoA
mutase alpha-subunit [Aeropyrum pernix]
Length = 565
Score = 692 bits (1767), Expect = 0.0
Identities = 334/561 (59%), Positives = 434/561 (76%), Gaps = 6/561 (1%)
Query: 3 FDVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLE 62
FD E +K+++ K+WE T+ ++LE+ PER E F T ++R+YTP DL ++WDYLE
Sbjct: 4 FDPEYVKRLEASLKKWESETLPQWLERMPERMESFTTLSDIPVRRLYTPLDL-KDWDYLE 62
Query: 63 KLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLP 122
KLGFPGEYPFTRG++ATMYR ++WTMR ++GY EE+NKR K+L+ G+TGLS+AFD P
Sbjct: 63 KLGFPGEYPFTRGIHATMYRAKLWTMRMFSGYGGPEETNKRLKFLIEHGETGLSLAFDEP 122
Query: 123 TQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYIL 182
T +G D D PLAEG VG GV + SL DM I+FDGI + +V+T+MTIN A LL+ Y+
Sbjct: 123 TLVGIDPDDPLAEGHVGIEGVNVASLKDMEIIFDGIDMGRVTTNMTINPPAPVLLSYYVA 182
Query: 183 VAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISI 242
VAE+QGVP K+ GT QND LKE+IA+ TY+FPP+ ++++ D+I + +N+PKWNPISI
Sbjct: 183 VAEKQGVPYHKIGGTTQNDPLKEFIAQKTYVFPPEAAVKIAIDVIEWSVKNLPKWNPISI 242
Query: 243 SGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAK 302
SGYHIREAGA AVQE+AFTLADGIEYV+ ++ RG+DVD FAPRLSFFF +H NF EEIAK
Sbjct: 243 SGYHIREAGATAVQELAFTLADGIEYVRQLLARGLDVDTFAPRLSFFFDSHINFFEEIAK 302
Query: 303 FRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGG 362
FRAARR+WA IMKEWF AK RSM LRFHTQTAG +L Q+P NNI+R AI+ALAAVLGG
Sbjct: 303 FRAARRMWAKIMKEWFGAKKKRSMWLRFHTQTAGVSLVVQEPYNNIVRTAIEALAAVLGG 362
Query: 363 TQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEE 422
TQSLHTNS+DE +P+E + +IALRTQQIIAYE+GV DT+DPLGG+YY+EWLTD I E
Sbjct: 363 TQSLHTNSFDEPFRVPSEFAAKIALRTQQIIAYETGVADTIDPLGGSYYVEWLTDEIEER 422
Query: 423 ALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVT---DEPI 479
A KYI+KI+ MGGM+ A++RGY QKE+ E+AYK+Q+++EEG++ IVGVN F + DE
Sbjct: 423 AWKYIDKIEAMGGMLEAVKRGYPQKEVTESAYKFQRDLEEGRKFIVGVNIFRSESIDEAR 482
Query: 480 EVEILKVD-PSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRH 538
V +L+ D I ++Q R+K++R R+ ++ ALD LR AAE+ EN+MPY++EA R
Sbjct: 483 NVPLLEFDQEEIEERQKRRVKEVRKMRNQERWRRALDNLRKAAER-GENIMPYVLEAARA 541
Query: 539 LATLQEVTDVLREIWGEYRAP 559
ATL E+ L+E++G Y P
Sbjct: 542 YATLGEIMGTLKEVYGVYVEP 562
>gb|AAG19017.1| (AE005001) methylmalonyl-CoA mutase, subunit alpha; McmA1
[Halobacterium sp. NRC-1]
Length = 653
Score = 685 bits (1748), Expect = 0.0
Identities = 342/557 (61%), Positives = 436/557 (77%), Gaps = 4/557 (0%)
Query: 3 FDVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFE-IKRIYTPADLGENWDYL 61
+D + L I++ + WEE T+ L++ ERKE F TD G + + R+YTP D+ + DY
Sbjct: 94 YDEDDLAAIRDGREDWEEETLGPTLDRFGERKESFETDTGGQSVDRLYTPDDVADR-DYD 152
Query: 62 EKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDL 121
+GFPGE P+TRGVY TMYRGR+WTMRQYAG TA E+N+R+ YLL +GQTGLS+AFDL
Sbjct: 153 ADIGFPGEEPYTRGVYPTMYRGRLWTMRQYAGMGTAAETNERFNYLLDEGQTGLSMAFDL 212
Query: 122 PTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYI 181
PTQ+GYDSD +A+GEVGK GVAID+L DM +FDGIPLD+VSTSMTINA A+ LLAMYI
Sbjct: 213 PTQMGYDSDATMAQGEVGKSGVAIDTLADMETVFDGIPLDEVSTSMTINAPASVLLAMYI 272
Query: 182 LVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPIS 241
V ++QGV +E+LRGT+QNDILKEYIAR TYIFPP+PSMR+ TDI +CA PK+N IS
Sbjct: 273 AVGDQQGVDREELRGTIQNDILKEYIARNTYIFPPEPSMRVITDIFEFCAAETPKFNTIS 332
Query: 242 ISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIA 301
ISGYHIREAGA A QE+AFTL DGIEYV+ ++ G+DVD+FAP+LSFFF AHNN LEE+A
Sbjct: 333 ISGYHIREAGATAAQEIAFTLGDGIEYVQTALDAGLDVDEFAPQLSFFFNAHNNILEEVA 392
Query: 302 KFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLG 361
KFRAARR+WA IM+E F+A+NP+S L+FHTQTAGSTLTAQQ +NNI+RVA QALAAVLG
Sbjct: 393 KFRAARRMWATIMEERFDAQNPKSKQLKFHTQTAGSTLTAQQIDNNIVRVAYQALAAVLG 452
Query: 362 GTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFE 421
GTQSLHTN DEALS+PTE+SVR ALRTQQI+A+ESG DT+DPL G+YY+E LTD I
Sbjct: 453 GTQSLHTNGKDEALSIPTEESVRTALRTQQILAHESGAADTIDPLAGSYYVEGLTDDIEA 512
Query: 422 EALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKF-VTDEPIE 480
EA ++++ GGM RA+E +VQ++I + A+ Q+EIEE +R+IVGVN+F V DE E
Sbjct: 513 EAQAILDEVDSRGGMRRAVEDQWVQRQIQDVAFDRQQEIEEKERVIVGVNEFEVDDEEPE 572
Query: 481 VEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLA 540
+I +V +QIE L ++ +RD++ VE AL LR AA DEN+MPYI+ A + A
Sbjct: 573 ADIEEVTADDERRQIEHLNDVKGDRDSEAVEAALADLR-AAAAGDENVMPYIVAAVKAYA 631
Query: 541 TLQEVTDVLREIWGEYR 557
++ E+ + LR+++GE++
Sbjct: 632 SVGEICNTLRDVFGEHQ 648
>emb|CAB71920.1| (AL138668) methylmalonyll-CoA mutase. [Streptomyces coelicolor
A3(2)]
Length = 531
Score = 660 bits (1685), Expect = 0.0
Identities = 325/518 (62%), Positives = 400/518 (76%), Gaps = 2/518 (0%)
Query: 39 TDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAE 98
++ G I+ +Y P L + WD EKLG PG+YPFTRGVY +MY GR WTMRQYAG+ TA
Sbjct: 11 SESGLPIEPVYGPDALAD-WDAAEKLGEPGKYPFTRGVYPSMYTGRPWTMRQYAGFGTAT 69
Query: 99 ESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGI 158
ESN RYK L++ G GLSVAFDLPTQ+G+DSD P+A GEVGKVGVAIDS+ DMR+LF GI
Sbjct: 70 ESNARYKQLIANGTMGLSVAFDLPTQMGHDSDAPIASGEVGKVGVAIDSIDDMRVLFGGI 129
Query: 159 PLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQP 218
PLDKVSTSMTINA A+ LL +Y LVAEEQGV +KL GT+QND+LKEYIARGTYIFPP+P
Sbjct: 130 PLDKVSTSMTINAPASLLLLLYQLVAEEQGVSADKLTGTIQNDVLKEYIARGTYIFPPKP 189
Query: 219 SMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMD 278
S+RL DI YC +PKWN ISISGYH+ EAGA+ QE+AFTLADGIEYV+ + GMD
Sbjct: 190 SLRLIADIFKYCRAEIPKWNTISISGYHMAEAGASPAQEIAFTLADGIEYVRTAVAAGMD 249
Query: 279 VDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGST 338
VD FAPRLSFFF A LEE+AKFRAARR+WA +MKE F AKNP+S+MLRFHTQTAG
Sbjct: 250 VDDFAPRLSFFFVARTTILEEVAKFRAARRIWARVMKEEFGAKNPKSLMLRFHTQTAGVQ 309
Query: 339 LTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESG 398
LTAQQPE N++RVA+Q L AVLGGTQSLHTNS+DEA++LPT+KS R+ALRTQQ++AYE+
Sbjct: 310 LTAQQPEVNLVRVAVQGLGAVLGGTQSLHTNSFDEAIALPTDKSARLALRTQQVLAYETD 369
Query: 399 VVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQK 458
V TVDP G+Y +E +TD + AL+ + K++ +GG + AIE G+ + EI +AY+ +
Sbjct: 370 VTATVDPFAGSYVVERMTDDVEAAALELMGKVEDLGGAVNAIEHGFQKNEIERSAYRIAQ 429
Query: 459 EIEEGKRIIVGVNKFVTDEPIEVEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLR 518
E + G+R++VGVN+F DE E L+VDP+I +Q ERL KLR+ERD + V+ AL LR
Sbjct: 430 ETDSGERVVVGVNRFQLDEEEPYEPLRVDPAIEAQQAERLAKLRAERDQQAVDSALAALR 489
Query: 519 NAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
AAE ED L P + +A R AT+ EV + LRE+WG Y
Sbjct: 490 KAAEGEDNVLYP-MKDALRARATVGEVCNALREVWGTY 526
>emb|CAC11604.1| (AL445064) probable methylmalonyl-CoA mutase, alpha subunit,
N-terminus [Thermoplasma acidophilum]
Length = 568
Score = 658 bits (1678), Expect = 0.0
Identities = 314/558 (56%), Positives = 424/558 (75%), Gaps = 3/558 (0%)
Query: 4 DVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEK 63
D K K EE +RW +T+ + + +++K+ +K +YT D+ D K
Sbjct: 13 DEFKTVKKNEEYERWVSSTLAPWNRQTGYKEKKYQNSSEITLKEVYTKEDVP---DLDRK 69
Query: 64 LGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPT 123
LG PGEYPFTRG+Y MYRG++WTMR ++G+ T E++N+R YL+ G+TGLS+AFD+PT
Sbjct: 70 LGMPGEYPFTRGIYPNMYRGKLWTMRMFSGFGTPEDTNRRLHYLIENGETGLSIAFDMPT 129
Query: 124 QLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILV 183
GYD+D+P +EGE+GK GV + +L DM +F GI L KVSTSMTINA AA L AMY+ +
Sbjct: 130 LYGYDADNPRSEGEIGKCGVNVSTLKDMETIFKGIDLSKVSTSMTINAPAAILTAMYLAI 189
Query: 184 AEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISIS 243
A++QGVP +K+ GTVQ DILKEYIA+ +++PP+ +R+ D+++YC +NVPKWN ISIS
Sbjct: 190 AKKQGVPFDKVSGTVQADILKEYIAQKEWMYPPEAHIRIIRDMMVYCTKNVPKWNYISIS 249
Query: 244 GYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKF 303
GYHIREAG++AVQE+AFTLADG YV I+ G++VD+FAPRLSFFF + NF EEIAK
Sbjct: 250 GYHIREAGSSAVQELAFTLADGFYYVDLGIKAGLNVDEFAPRLSFFFNSSINFFEEIAKM 309
Query: 304 RAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGT 363
RAARR+WA ++KE + AKNPRSMMLRFHTQT+G TLT QQP NNIIR I+A+AAVLGGT
Sbjct: 310 RAARRIWATVLKEKYGAKNPRSMMLRFHTQTSGYTLTWQQPLNNIIRTTIEAMAAVLGGT 369
Query: 364 QSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEA 423
QSLHTNSYDEA +LP++++V++ALRTQQIIA ESG+ D +DPLGG+YY+EWLTD + EEA
Sbjct: 370 QSLHTNSYDEAWALPSDQAVKVALRTQQIIAEESGIPDVIDPLGGSYYVEWLTDRMEEEA 429
Query: 424 LKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEI 483
+Y ++I+ MGG++ AI++GY+QKEIA+ +YK QK +E G+ I+VGVNK++ + +
Sbjct: 430 YRYFDRIESMGGILEAIKKGYIQKEIADTSYKRQKRLESGEEIMVGVNKYIEEGEEPINY 489
Query: 484 LKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQ 543
LK+D + QI RLK+++S RD +KV +AL+ LR A E+ENLMPY I A AT+Q
Sbjct: 490 LKIDKKAEEAQIARLKEVKSTRDEEKVRKALEDLRKAMLDENENLMPYYIRAVEAYATVQ 549
Query: 544 EVTDVLREIWGEYRAPLI 561
E++DV REI+G ++ P+I
Sbjct: 550 EISDVGREIFGSWKEPVI 567
>emb|CAC17657.1| (AL450450) methylmalonyl CoA mutase [Streptomyces coelicolor]
Length = 534
Score = 651 bits (1661), Expect = 0.0
Identities = 319/518 (61%), Positives = 398/518 (76%), Gaps = 2/518 (0%)
Query: 39 TDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAE 98
++ G I+ +Y P L + W+ EKLG PG+YPFTRGVY +MY GR WTMRQYAG+ TA
Sbjct: 13 SESGLPIEPVYGPEALAD-WEAAEKLGEPGKYPFTRGVYPSMYTGRPWTMRQYAGFGTAT 71
Query: 99 ESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGI 158
ESN RYK L++ G GLSVAFDLPTQ+G+DSD P+A GEVGKVGVAIDS+ DMR+LF GI
Sbjct: 72 ESNARYKQLIANGTMGLSVAFDLPTQMGHDSDAPIASGEVGKVGVAIDSIDDMRVLFGGI 131
Query: 159 PLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQP 218
PLDKVSTSMTINA A+ LL +Y LVAEEQGV ++L GT+QND+LKEYIARGTYIFPP+P
Sbjct: 132 PLDKVSTSMTINAPASLLLLLYQLVAEEQGVSADQLTGTIQNDVLKEYIARGTYIFPPKP 191
Query: 219 SMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMD 278
S+RL DI YC +PKWN ISISGYH+ EAGA+ QE+AFTLADGIEYV+ + GMD
Sbjct: 192 SLRLIADIFKYCRAEIPKWNTISISGYHMAEAGASPAQEIAFTLADGIEYVRTAVAAGMD 251
Query: 279 VDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGST 338
VD FAPRLSFFF A LEE+AKFRAARR+WA +MKE F AKNP+S+MLRFHTQTAG
Sbjct: 252 VDDFAPRLSFFFVARTTILEEVAKFRAARRIWARVMKEEFGAKNPKSLMLRFHTQTAGVQ 311
Query: 339 LTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESG 398
LTAQQPE N++RVA+Q L AVLGGTQSLHTNS+DEA++LPT+KS R+ALRTQQ++AYE+
Sbjct: 312 LTAQQPEVNLVRVAVQGLGAVLGGTQSLHTNSFDEAIALPTDKSARLALRTQQVLAYETD 371
Query: 399 VVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQK 458
V TVDP G+Y +E +TD + AL+ + K++ +GG + AIE G+ + EI +AY+ +
Sbjct: 372 VTATVDPFAGSYVVEKMTDDVEAAALELMGKVEDLGGAVNAIEHGFQKSEIERSAYRIAQ 431
Query: 459 EIEEGKRIIVGVNKFVTDEPIEVEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLR 518
E + G+R++VGVN++ DE E L+VDP+I +Q +RL LR+ERD V+ AL L+
Sbjct: 432 ETDSGERVVVGVNRYQLDEEEPYEPLRVDPAIEAQQADRLAALRAERDQTAVDSALAALK 491
Query: 519 NAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
AAE ED L P + +A R AT+ EV + LRE+WG Y
Sbjct: 492 KAAEGEDNVLYP-MKDALRARATVGEVCNALREVWGTY 528
>pir||D75425 methylmalonyl-CoA mutase (EC 5.4.99.2) chain A [similarity] -
Deinococcus radiodurans (strain R1)
>gi|6458931|gb|AAF10762.1|AE001968_1 (AE001968)
methylmalonyl-CoA mutase, alpha subunit, chain A
[Deinococcus radiodurans]
Length = 561
Score = 598 bits (1525), Expect = e-170
Identities = 300/547 (54%), Positives = 398/547 (71%), Gaps = 3/547 (0%)
Query: 15 EKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTR 74
+ W ++ + +K PERK F + + IYT DL + WD LG+PGE+P+TR
Sbjct: 17 KNEWMQSVYQPATQKFPERKYNFKNLSDMDPEPIYTADDLTD-WDAERDLGYPGEFPYTR 75
Query: 75 GVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLA 134
GV +++YRG++WTMR +AG+ +AE++N+R+ LL GQTGLS AFDLPT +GYDSDHP +
Sbjct: 76 GVQSSVYRGKLWTMRMFAGFXSAEQTNERFHSLLKAGQTGLSTAFDLPTLMGYDSDHPFS 135
Query: 135 EGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKL 194
+GEVGK GVA+ SL DM ILF GI V+TSMTIN+ A + AMYI A++QG K+
Sbjct: 136 KGEVGKCGVAVSSLADMEILFQGIDPTAVTTSMTINSPANAVWAMYIANAQKQGKDLGKV 195
Query: 195 RGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANA 254
GT+QNDILKE+IA+ +I+PP PS++L D + + +PKWN IS+SGYHIREAGA
Sbjct: 196 GGTIQNDILKEFIAQKEFIYPPAPSVKLVIDTFEWGPKMLPKWNFISVSGYHIREAGATG 255
Query: 255 VQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIM 314
VQE+AFTLADG YV+ +ERG+D+D+FAPR+SFF+ HN+F EEIAK RAARR+WA M
Sbjct: 256 VQELAFTLADGFHYVEKALERGLDIDEFAPRISFFWDIHNDFFEEIAKLRAARRIWARQM 315
Query: 315 KEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEA 374
++ + AKNP+S MLR H+QTAG +L AQQP NNI RVAIQALAAVLGGTQSLHT+++DEA
Sbjct: 316 RDRYGAKNPKSWMLRTHSQTAGVSLPAQQPLNNIARVAIQALAAVLGGTQSLHTDAFDEA 375
Query: 375 LSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMG 434
L+LPTE+S IALRTQQIIAYE+GV VDPL G+YY+E LT+ I A+ YIE+I+ MG
Sbjct: 376 LALPTEESAAIALRTQQIIAYETGVAGVVDPLAGSYYVEKLTNDIEAAAMGYIEQIRMMG 435
Query: 435 GMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVDPSIRDKQ 494
G+ I+ G+ Q E+AEAAY+YQ+E+E RIIVGVN++V D +EV I +DP + + Q
Sbjct: 436 GVEAGIDNGFFQLEMAEAAYRYQREVETKDRIIVGVNEYVQD-AVEVPIQIIDPKVEELQ 494
Query: 495 IERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWG 554
RL ++R ERD ++ E+AL+ LR+ A N MP +E TL E D L+ ++G
Sbjct: 495 ASRLAQVRRERDPQRAEKALEALRDTA-VTGANSMPAFLECAHAYCTLGEQMDTLKAVYG 553
Query: 555 EYRAPLI 561
EY P++
Sbjct: 554 EYTEPVM 560
>gb|AAG19151.1| (AE005013) methylmalonyl-CoA mutase, subunit alpha; McmA1
[Halobacterium sp. NRC-1]
Length = 526
Score = 591 bits (1506), Expect = e-168
Identities = 287/521 (55%), Positives = 393/521 (75%), Gaps = 9/521 (1%)
Query: 44 EIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKR 103
E+ R+YTPAD+ + DY E LGFPGE+P+TRGVY T YRGR WTMRQ+AG+ TAEE+N+R
Sbjct: 2 EVDRLYTPADVADT-DYNEDLGFPGEFPYTRGVYPTGYRGRTWTMRQFAGFGTAEETNER 60
Query: 104 YKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKV 163
+ YL+ GQTGLS AFD+P+ +G DSDH ++ GEVGK GVA+D+L DM ILFDGI L V
Sbjct: 61 FHYLIDNGQTGLSTAFDMPSLMGLDSDHRMSLGEVGKEGVAVDTLRDMEILFDGIDLAAV 120
Query: 164 STSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLT 223
STS TIN +A + AMY+ +A++QGVP+E +RGT+QND+LKE+IA+ ++ PP PS+ L
Sbjct: 121 STSFTINPSAPVIYAMYLALADQQGVPREDIRGTLQNDMLKEFIAQKEWVVPPTPSLDLV 180
Query: 224 TDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFA 283
TD++ YC P ++PIS+SGYHIREAG+ AVQE+AFTLADG YV+ I+RG+DVD FA
Sbjct: 181 TDVVEYCVAETPNFHPISVSGYHIREAGSTAVQELAFTLADGFAYVEDAIDRGLDVDAFA 240
Query: 284 PRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQ 343
P+LSFFF +HN EE+AKFRAARR++A +M +W+ A+ + L+FHTQTAG +LTAQQ
Sbjct: 241 PQLSFFFNSHNAIFEEVAKFRAARRIYATLMDDWYGAEADAATQLKFHTQTAGQSLTAQQ 300
Query: 344 PENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTV 403
P+NNI RV +QALAAVLGG+QS+HTNS+DEAL+LP+E++VR+ALRTQQIIA ESG D V
Sbjct: 301 PKNNIARVTLQALAAVLGGSQSIHTNSFDEALALPSEEAVRVALRTQQIIAEESGAADIV 360
Query: 404 DPLGGAYYIEWLTDHIFEEALKYIEKIQKMG------GMMRAIERGYVQKEIAEAAYKYQ 457
DPLGG++ +E LT+ I EA+ Y+ +I+++G G++ I GY +EI E+AY+YQ
Sbjct: 361 DPLGGSFAVESLTNEIEAEAMAYLTEIKELGDGSVRDGVLAGIADGYFHREIQESAYEYQ 420
Query: 458 KEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIERLKKLRSERDNKKVEEALDK 516
+++G+ +VGVN+ D + L VD + RD+Q+ RL +++ERD+ VE L +
Sbjct: 421 SRVDDGEETVVGVNEHEMDADTSPDTLHVDAEATRDRQLGRLSDVKAERDDDAVEATLAE 480
Query: 517 LRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEYR 557
LR A + DEN +PYI+ A + AT+ E+ V ++ +G Y+
Sbjct: 481 LR-AGIRADENTIPYIVAAVKAYATMGEIMAVFKDEFGGYQ 520
>pir||S13043 methylmalonyl-CoA mutase (EC 5.4.99.2) - mouse
Length = 748
Score = 551 bits (1404), Expect = e-156
Identities = 278/542 (51%), Positives = 378/542 (69%), Gaps = 7/542 (1%)
Query: 18 WEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVY 77
W K+ K PE + T +G IK +Y+ AD D E+L PG PFTRG Y
Sbjct: 41 WAVLAKKQLKGKNPEDLI-WHTPEGISIKPLYSRAD---TLDLPEEL--PGVKPFTRGPY 94
Query: 78 ATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGE 137
TMY R WT+RQYAG++T EESNK YK + GQ GLSVAFDL T GYDSD+P G+
Sbjct: 95 PTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGD 154
Query: 138 VGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGT 197
VG GVAID++ D +ILFDGIPL+K+S SMT+N +LA +I+ EEQGVP+EKL GT
Sbjct: 155 VGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGT 214
Query: 198 VQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQE 257
+QNDILKE++ R TYIFPP+PSM++ DI Y A+++PK+NPISISGYH++EAG +A+ E
Sbjct: 215 IQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNPISISGYHMQEAGTDAILE 274
Query: 258 VAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEW 317
+A+T+ADG+EY + ++ G+ +D+FAPRLSFF+ NF EIAK RA RRLWA+++++
Sbjct: 275 LAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKM 334
Query: 318 FNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSL 377
F KN +S++LR H QT+G +LT Q P NNI+R AI+A+AAV GGTQSLH+NS+DEAL L
Sbjct: 335 FQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHSNSFDEALGL 394
Query: 378 PTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMM 437
PT KS RIA TQ II ESG+ DP GG+Y +E LT+ ++E ALK I ++++MGGM
Sbjct: 395 PTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMA 454
Query: 438 RAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIE 496
+A+ G + I E A + Q I+ G +IVGVNK+ ++ VE+L +D S+R KQIE
Sbjct: 455 KAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDSVEVLAIDNTSVRKKQIE 514
Query: 497 RLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
+LKK++S RD E+ L L A D N++ ++A R T+ E+TD L++++GE+
Sbjct: 515 KLKKIKSSRDQALAEQCLSALTQCAASGDGNILALAVDAARARCTVGEITDALKKVFGEH 574
Query: 557 RA 558
+A
Sbjct: 575 KA 576
>gi|4557767 methylmalonyl Coenzyme A mutase precursor [Homo sapiens]
>gi|547946|sp|P22033|MUTA_HUMAN METHYLMALONYL-COA
MUTASE, MITOCHONDRIAL PRECURSOR (MCM)
>gi|7513150|pir||A59145 methylmalonyl-CoA mutase (EC
5.4.99.2) precursor [validated] - human
>gi|187452|gb|AAA59569.1| (M65131) methylmalonyl-CoA
mutase [Homo sapiens]
Length = 750
Score = 547 bits (1395), Expect = e-154
Identities = 278/542 (51%), Positives = 377/542 (69%), Gaps = 7/542 (1%)
Query: 18 WEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVY 77
W K+ K PE + T +G IK +Y+ D D E+L PG PFTRG Y
Sbjct: 43 WAALAKKQLKGKNPEDLI-WHTPEGISIKPLYSKRD---TMDLPEEL--PGVKPFTRGPY 96
Query: 78 ATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGE 137
TMY R WT+RQYAG++T EESNK YK + GQ GLSVAFDL T GYDSD+P G+
Sbjct: 97 PTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGD 156
Query: 138 VGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGT 197
VG GVAID++ D +ILFDGIPL+K+S SMT+N +LA +I+ EEQGVP+EKL GT
Sbjct: 157 VGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGT 216
Query: 198 VQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQE 257
+QNDILKE++ R TYIFPP+PSM++ DI Y A+++PK+N ISISGYH++EAGA+A+ E
Sbjct: 217 IQNDILKEFMVRNTYIFPPEPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILE 276
Query: 258 VAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEW 317
+A+TLADG+EY + ++ G+ +D+FAPRLSFF+ NF EIAK RA RRLWA+++++
Sbjct: 277 LAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKM 336
Query: 318 FNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSL 377
F KN +S++LR H QT+G +LT Q P NNI+R AI+A+AAV GGTQSLHTNS+DEAL L
Sbjct: 337 FQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGL 396
Query: 378 PTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMM 437
PT KS RIA TQ II ESG+ DP GG+Y +E LT+ +++ ALK I +I++MGGM
Sbjct: 397 PTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMA 456
Query: 438 RAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIE 496
+A+ G + I E A + Q I+ G +IVGVNK+ ++ VE+L +D S+R++QIE
Sbjct: 457 KAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDAVEVLAIDNTSVRNRQIE 516
Query: 497 RLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
+LKK++S RD E L L A D N++ ++A R T+ E+TD L++++GE+
Sbjct: 517 KLKKIKSSRDQALAEHCLAALTECAASGDGNILALAVDASRARCTVGEITDALKKVFGEH 576
Query: 557 RA 558
+A
Sbjct: 577 KA 578
>gi|6678970 methylmalonyl-Coenzyme A mutase [Mus musculus]
>gi|127548|sp|P16332|MUTA_MOUSE METHYLMALONYL-COA
MUTASE, MITOCHONDRIAL PRECURSOR (MCM)
>gi|91084|pir||S08680 methylmalonyl-CoA mutase (EC
5.4.99.2) precursor - mouse >gi|53151|emb|CAA36204.1|
(X51941) precursor polypeptide (AA -30 to 718) [Mus
musculus]
Length = 748
Score = 544 bits (1387), Expect = e-154
Identities = 275/542 (50%), Positives = 376/542 (68%), Gaps = 7/542 (1%)
Query: 18 WEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVY 77
W K+ K PE + T +G IK +Y+ AD D E+L PG PFTRG Y
Sbjct: 41 WAVLAKKQLKGKNPEDLI-WHTPEGISIKPLYSRAD---TLDLPEEL--PGVKPFTRGPY 94
Query: 78 ATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGE 137
TMY R WT+RQYAG++T EESNK YK + GQ GLSVAFDL T GYDSD+P G+
Sbjct: 95 PTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGD 154
Query: 138 VGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGT 197
VG GVAID++ D +ILFDGIPL+K+S SMT+N +LA +I+ EEQGVP+EKL GT
Sbjct: 155 VGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGT 214
Query: 198 VQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQE 257
+QNDILKE++ R TYIFPP+PSM++ DI Y A+++PK+NPISISGYH++EAG +A+ E
Sbjct: 215 IQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNPISISGYHMQEAGTDAILE 274
Query: 258 VAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEW 317
+A+T+ADG+EY + ++ G+ +D+FAPRLSFF+ NF EIAK RA RRLWA+++++
Sbjct: 275 LAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKM 334
Query: 318 FNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSL 377
F KN +S++LR H QT+G +LT Q P NNI+R AI+A+AAV GGTQSLH+NS+DEAL L
Sbjct: 335 FQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHSNSFDEALGL 394
Query: 378 PTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMM 437
PT KS RIA T+ II ESG+ DP GG+Y +E LT+ ++E ALK I ++++MGGM
Sbjct: 395 PTVKSARIARNTRIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMA 454
Query: 438 RAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIE 496
+A+ G + I E A + Q I+ G +IVGVNK+ ++ V +L +D S+R KQIE
Sbjct: 455 KAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYHLEKEDSVHLLAIDIISLRKKQIE 514
Query: 497 RLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
+LKK++S RD E+ L L A D N++ ++A R T+ E+TD ++++GE+
Sbjct: 515 KLKKIKSSRDQALAEQCLSALTQCAASGDGNILALAVDAARARCTVPEITDAFKKVFGEH 574
Query: 557 RA 558
+A
Sbjct: 575 KA 576
>pir||T46549 isobutyryl-CoA mutase (EC 5.4.99.13) chain A [validated] -
Streptomyces cinnamonensis >gi|3002492|gb|AAC08713.1|
(U67612) coenzyme B12-dependent isobutyrylCoA mutase
[Streptomyces cinnamonensis]
Length = 566
Score = 543 bits (1384), Expect = e-153
Identities = 277/565 (49%), Positives = 384/565 (67%), Gaps = 23/565 (4%)
Query: 11 IKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEY 70
I+E +RW+ +KA +R F T G + +Y P G+ +D E++G+PGEY
Sbjct: 6 IEEGRRRWQAR-----YDKARKRDADFTTLSGDPVDPVYGPRP-GDTYDGFERIGWPGEY 59
Query: 71 PFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSD 130
PFTRG+YAT YRGR WT+RQ+AG+ AE++N+RYK +L+ G GLSVAFD+PT +G DSD
Sbjct: 60 PFTRGLYATGYRGRTWTIRQFAGFGNAEQTNERYKMILANGGGGLSVAFDMPTLMGRDSD 119
Query: 131 HPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVP 190
P + GEVG GVAIDS DM +LF IPL V+TSMTI+ A + MY++ AE QGV
Sbjct: 120 DPRSLGEVGHCGVAIDSAADMEVLFKDIPLGDVTTSMTISGPAVPVFCMYLVAAERQGVD 179
Query: 191 QEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREA 250
L GT+Q DI KEYIA+ ++F P+P +RL D++ +CA ++P + P+S+SGYHIREA
Sbjct: 180 PAVLNGTLQTDIFKEYIAQKEWLFQPEPHLRLIGDLMEHCARDIPAYKPLSVSGYHIREA 239
Query: 251 GANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLW 310
GA A QE+A+TLADG YV+ + RG+DVD FAP LSFFF AH +F EEIAKFRAARR+W
Sbjct: 240 GATAAQELAYTLADGFGYVELGLSRGLDVDVFAPGLSFFFDAHVDFFEEIAKFRAARRIW 299
Query: 311 AYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNS 370
A +++ + AK ++ LRFHTQTAG +LTAQQP NN++R A++ALAAVLGGT SLHTN+
Sbjct: 300 ARWLRDEYGAKTEKAQWLRFHTQTAGVSLTAQQPYNNVVRTAVEALAAVLGGTNSLHTNA 359
Query: 371 YDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKI 430
DE L+LP+E++ IALRTQQ++ E+GV + DPLGG++YIE LTD I +A K E+I
Sbjct: 360 LDETLALPSEQAAEIALRTQQVLMEETGVANVADPLGGSWYIEQLTDRIEADAEKIFEQI 419
Query: 431 QKMG----------------GMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFV 474
++ G G++R IE G+ EIAE+A++YQ+ +E+G + +VGVN
Sbjct: 420 RERGRRACPDGQHPIGPITSGILRGIEDGWFTGEIAESAFQYQRSLEKGDKRVVGVNCLE 479
Query: 475 TDEPIEVEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIE 534
++EIL+V + +Q+ L + RD+ +V +LD + AA ++ N++ ++E
Sbjct: 480 GSVTGDLEILRVSHEVEREQVRELAGRKGRRDDARVRASLDAML-AAARDGSNMIAPMLE 538
Query: 535 AHRHLATLQEVTDVLREIWGEYRAP 559
A R ATL E+ VLR+ WG Y P
Sbjct: 539 AVRAEATLGEICGVLRDEWGVYVEP 563
>emb|CAC17595.1| (AJ300476) methylmalonyl-CoA mutase [Bos taurus]
Length = 750
Score = 542 bits (1381), Expect = e-153
Identities = 276/542 (50%), Positives = 375/542 (68%), Gaps = 7/542 (1%)
Query: 18 WEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVY 77
W K+ K PE + T +G IK +Y+ D D E+L PG PFTRG Y
Sbjct: 43 WAALAKKQLKGKNPEDLI-WHTPEGISIKPLYSKRD---TMDLPEEL--PGVKPFTRGPY 96
Query: 78 ATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGE 137
TMY R WT+RQYAG++T EESNK YK + GQ GLSVAFDL T GYDSD+P G+
Sbjct: 97 PTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRLRGD 156
Query: 138 VGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGT 197
VG GVAID++ D +ILFDGIPL+K+S SMT+N +LA +I+ EEQGVP+EKL GT
Sbjct: 157 VGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGT 216
Query: 198 VQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQE 257
+QNDILKE++ R TYIFPP+PSM++ DI Y A+++PK+N ISISGYH++EAGA+A+ E
Sbjct: 217 IQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAKHMPKFNSISISGYHMQEAGADAILE 276
Query: 258 VAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEW 317
+A+T+ADG+EY + ++ G+ +D+FAPRLSFF+ NF EIAK RA RRLWA+++++
Sbjct: 277 LAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKM 336
Query: 318 FNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSL 377
KN +S++LR H QT+G +LT Q P NNIIR I+A+AAV GGTQSLHTNS+DEAL L
Sbjct: 337 LQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIIRTTIEAMAAVFGGTQSLHTNSFDEALGL 396
Query: 378 PTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMM 437
PT KS RIA TQ II ESG+ DP GG+Y +E LT+ I++ ALK I +I++MGGM
Sbjct: 397 PTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDIYDAALKLINEIEEMGGMA 456
Query: 438 RAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIE 496
+A+ G + I E A + Q I+ G +IVGVNK+ ++ V++L +D S+R+KQIE
Sbjct: 457 KAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEESVDVLAIDNTSVRNKQIE 516
Query: 497 RLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
+LKK++S RD E LD L A D N++ ++A R T+ E+T +++++GE+
Sbjct: 517 KLKKVKSSRDQALAERCLDALTACAASGDGNILALAVDATRARCTVGEITYAMKKVFGEH 576
Query: 557 RA 558
+A
Sbjct: 577 KA 578
>pir||F75440 methylmalonyl-CoA mutase, beta subunit - Deinococcus radiodurans
(strain R1) >gi|6458814|gb|AAF10655.1|AE001958_9
(AE001958) methylmalonyl-CoA mutase, beta subunit
[Deinococcus radiodurans]
Length = 711
Score = 538 bits (1372), Expect = e-152
Identities = 278/522 (53%), Positives = 366/522 (69%), Gaps = 8/522 (1%)
Query: 39 TDDGFEIKRIYTPADL-GENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATA 97
T +G +K +YT AD G N D L PG P+TRG ATMY R WT+RQYAG++TA
Sbjct: 33 TPEGLTLKPLYTRADTAGLNTDTL-----PGLPPYTRGPRATMYAARPWTIRQYAGFSTA 87
Query: 98 EESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDG 157
EESN Y+ L+ GQ GLSVAFDL T GYDSDHP G+VGK GVAIDS+ DM+ILFDG
Sbjct: 88 EESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVEDMKILFDG 147
Query: 158 IPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQ 217
IPL+++S SMT+N +LA YI+V EQG E+L GT+QNDILKE++ R TYI+PP+
Sbjct: 148 IPLNEMSVSMTMNGAVLPILAGYIVVGLEQGAKLEELSGTIQNDILKEFMVRNTYIYPPE 207
Query: 218 PSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGM 277
PSMR+ DII Y A+N+P++N ISISGYH++EAGANA E+A+TL+DG+EYV+A + +G+
Sbjct: 208 PSMRIIADIIEYTAQNMPRFNSISISGYHLQEAGANAALELAYTLSDGLEYVRAALGKGL 267
Query: 278 DVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGS 337
DVD FAPRLSFFFA NF E+AK RAAR LW IM + F+ KNP S LR H QT+G
Sbjct: 268 DVDAFAPRLSFFFAIGMNFYTEVAKLRAARLLWDEIMAQ-FSPKNPMSRALRTHCQTSGW 326
Query: 338 TLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYES 397
+LT Q P NN++R A++A+AAV GGTQSLHTNS+DEA+ LPT+ S RIA TQ II E+
Sbjct: 327 SLTEQDPYNNVVRTAVEAMAAVFGGTQSLHTNSFDEAIGLPTDFSARIARNTQLIIQEET 386
Query: 398 GVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQ 457
G+ VDP GG+Y +E LT + E+A + + +++ +GGM +AIE G + I E+A + Q
Sbjct: 387 GIPQVVDPWGGSYLMERLTHDLAEKARELMREVESLGGMAKAIESGVPKLRIEESAARKQ 446
Query: 458 KEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIERLKKLRSERDNKKVEEALDK 516
I+ G+ +IVGVNK+ V++L +D ++R+ QI RL KLR ERD + V+ AL
Sbjct: 447 ARIDRGEDVIVGVNKYRPTAETPVDVLDIDNAAVRESQIARLNKLRGERDGEAVQAALSA 506
Query: 517 LRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEYRA 558
L A+ NL+ +EA + TL EV+D L ++WG + A
Sbjct: 507 LTECAKTGQGNLLALSVEAMKVRCTLGEVSDALEKVWGRHSA 548
>gb|AAA99226.1| (M37510) methylmalonyl-CoA mutase [Homo sapiens]
Length = 750
Score = 536 bits (1367), Expect = e-151
Identities = 276/542 (50%), Positives = 371/542 (67%), Gaps = 7/542 (1%)
Query: 18 WEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVY 77
W K+ K PE + T +G IK +Y+ D D E+L PG PFTRG Y
Sbjct: 43 WAALAKKQLKGKNPEDLI-WHTPEGISIKPLYSKRD---TMDLPEEL--PGVKPFTRGPY 96
Query: 78 ATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGE 137
TMY R WT+RQYAG++T EESNK YK + GQ GLSVAFDL T GYDSD+P G+
Sbjct: 97 PTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRLRGD 156
Query: 138 VGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGT 197
VG GVAID++ D +ILFDGIPL+K+S SMT+N +LA +I+ EEQGVP+EKL GT
Sbjct: 157 VGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGT 216
Query: 198 VQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQE 257
+QNDILKE++ R TYIFPP PSM++ DI Y A+++PK+N ISISGYH++EAGA+A
Sbjct: 217 IQNDILKEFMVRNTYIFPPDPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAFWS 276
Query: 258 VAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEW 317
A+TLADG+EY + ++ G+ +D+FAPRLSFF+ NF EIAK RA RRLWA+++++
Sbjct: 277 WAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFHMEIAKMRAGRRLWAHLIEKM 336
Query: 318 FNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSL 377
F KN +S++LR H QT+G +LT Q P NNI+R AI+A+AAV GGTQSLHTNS+DEAL L
Sbjct: 337 FQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGL 396
Query: 378 PTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMM 437
PT KS RIA TQ II ESG+ DP GG+Y +E LT+ +++ ALK I +I++MGGM
Sbjct: 397 PTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMA 456
Query: 438 RAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIE 496
+A+ G + I E A + Q I+ G +IVGVNK+ ++ VE+L D S+R++QI
Sbjct: 457 KAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDAVEVLATDNTSVRNRQIG 516
Query: 497 RLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
+LKK++S RD E L L A D N++ ++A R T+ E+TD L++++GE+
Sbjct: 517 KLKKIKSSRDQALAEHCLAALTECAASGDGNILALAVDASRARCTVGEITDALKKVFGEH 576
Query: 557 RA 558
+A
Sbjct: 577 KA 578
>sp|O86028|MUTB_RHIME METHYLMALONYL-COA MUTASE (MCM) >gi|3549312|gb|AAD13665.1|
(AF080073) methylmalonyl-CoA mutase [Sinorhizobium
meliloti]
Length = 712
Score = 536 bits (1366), Expect = e-151
Identities = 277/544 (50%), Positives = 381/544 (69%), Gaps = 7/544 (1%)
Query: 16 KRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRG 75
K WE K+ L +PE + T +G ++K +YT D+ +L L PG PF R
Sbjct: 7 KDWEALAEKE-LRVSPEGLV-WHTPEGIDVKPLYTSDDMS-GIRHLNSL--PGFEPFVRR 61
Query: 76 VYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAE 135
ATMY GR WT+RQYAG++TAE SN Y+ L+ GQ G+SVAFDL T GYDSDHP +
Sbjct: 62 PRATMYAGRPWTVRQYAGFSTAEASNAFYRRNLAAGQQGVSVAFDLATHRGYDSDHPRVQ 121
Query: 136 GEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLR 195
G+VGK GVAIDS+ DM+ILFDGIPLD++S SMT+ +LA +I+ EEQGV ++KL
Sbjct: 122 GDVGKAGVAIDSVEDMKILFDGIPLDRISVSMTMKGAVIPILASFIVAGEEQGVSRDKLS 181
Query: 196 GTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAV 255
GT+QNDILKE++ R TYI+PP+PSMR+ DII Y A+ +PK+N ISISGYH++EAGA V
Sbjct: 182 GTIQNDILKEFMVRNTYIYPPEPSMRIVADIIEYTAKEMPKFNSISISGYHMQEAGATLV 241
Query: 256 QEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMK 315
QE+AFTLADG EYV+A + +G++VD FA RLSFFFA NF E AK RAAR LW IM+
Sbjct: 242 QELAFTLADGREYVRAALAKGLNVDDFAGRLSFFFAIGMNFFMEAAKLRAARLLWTRIMQ 301
Query: 316 EWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEAL 375
E F + S+MLR H QT+G +L Q P NNI+R A +A++AVLGGTQSLHTNS+DEA+
Sbjct: 302 E-FKPEKASSLMLRTHCQTSGVSLQEQDPYNNIVRTAFEAMSAVLGGTQSLHTNSFDEAM 360
Query: 376 SLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGG 435
+LPT+ S RIA TQ I+ +E+GV VDPL G+YY+E LT+ + E+A IE+++ +GG
Sbjct: 361 ALPTDFSARIARNTQLILQHETGVTKVVDPLAGSYYVESLTNELAEKAWGLIEEVEALGG 420
Query: 436 MMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQ 494
M +A+ G ++ I EAA + Q ++ + +IVGVNK+ + ++IL++D ++R Q
Sbjct: 421 MTKAVNAGLPKRLIEEAATRRQAAVDRAEEVIVGVNKYRLENEQPIDILQIDNAAVRTAQ 480
Query: 495 IERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWG 554
++R+++ R RD++K+++ALD L + A NL+ +EA R AT+ E+TD +RE +G
Sbjct: 481 VKRIEETRRRRDSQKMKQALDALADVARSGKGNLLAAAVEAARARATVGEITDAMREAFG 540
Query: 555 EYRA 558
+Y A
Sbjct: 541 DYTA 544
>sp|Q23381|MUTA_CAEEL PROBABLE METHYLMALONYL-COA MUTASE, MITOCHONDRIAL PRECURSOR (MCM)
>gi|7510897|pir||T27674 hypothetical protein ZK1058.1 -
Caenorhabditis elegans >gi|3881495|emb|CAA84676.1|
(Z35604) contains similarity to Pfam domain: PF01642
(Methylmalonyl-CoA mutase), Score=1148.4, E-value=0,
N=1~cDNA EST EMBL:M89407 comes from this gene~cDNA EST
CEMSB12F comes from this gene~cDNA EST yk20d12.3 comes
from this gene~cDNA EST yk23a1.3 com>
Length = 744
Score = 535 bits (1364), Expect = e-151
Identities = 275/545 (50%), Positives = 377/545 (68%), Gaps = 5/545 (0%)
Query: 15 EKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTR 74
+++W KK ++ + T +G IK +Y +D + D + PG++PFTR
Sbjct: 29 DQKWA-AMAKKAMKGREATTLTWNTPEGIPIKPLYLRSD--RDCDAQRSVELPGQFPFTR 85
Query: 75 GVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLA 134
G Y TMY R WT+RQYAG++T EESNK YK + GQ GLSVAFDL T GYDSD+P
Sbjct: 86 GPYPTMYTQRPWTIRQYAGFSTVEESNKFYKENIKAGQQGLSVAFDLATHRGYDSDNPRV 145
Query: 135 EGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKL 194
G+VG GVA+DS+ DMR LFDGI L+K+S SMT+N +LAMY++ AEE GV ++ L
Sbjct: 146 FGDVGMAGVAVDSVEDMRQLFDGINLEKMSVSMTMNGAVVPVLAMYVVAAEEAGVSRKLL 205
Query: 195 RGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANA 254
GT+QNDILKE++ R TYI+PP+PSMR+ DI Y + +PK+N ISISGYH++EAGA+A
Sbjct: 206 AGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIFAYTSREMPKFNSISISGYHMQEAGADA 265
Query: 255 VQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIM 314
V E+AFT+ADGI+Y + + G+ +D FAPRLSFF+ NF EIAK RAARRLWA ++
Sbjct: 266 VLEMAFTIADGIQYCETGLNAGLTIDAFAPRLSFFWGISMNFYMEIAKMRAARRLWANLI 325
Query: 315 KEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEA 374
KE F+ K+ +SMMLR H+QT+G +LT Q P NNIIR I+A+A+V GGTQSLHTNS+DEA
Sbjct: 326 KERFSPKSDKSMMLRTHSQTSGWSLTEQDPYNNIIRTTIEAMASVFGGTQSLHTNSFDEA 385
Query: 375 LSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMG 434
L LPT+ S RIA TQ II ESG+ + DP GG+Y +E LTD I+E+AL I++I ++G
Sbjct: 386 LGLPTKFSARIARNTQIIIQEESGICNVADPWGGSYMMESLTDEIYEKALAVIKEIDELG 445
Query: 435 GMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDK 493
GM +A+ G + +I EAA K Q I+ GK +IVGVNK+ D +VE+LK+D +R++
Sbjct: 446 GMAKAVASGMTKLKIEEAAAKKQARIDAGKDVIVGVNKYRLDHEQQVEVLKIDNAKVREE 505
Query: 494 QIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIW 553
Q +L +R+ RD +K ++ALD + A + + NLM IEA R T+ E++D + +++
Sbjct: 506 QCAKLNHIRATRDAEKAQKALDAITEGA-RGNGNLMELAIEAARARCTVGEISDAMEKVF 564
Query: 554 GEYRA 558
+ A
Sbjct: 565 NRHAA 569
>sp|Q05065|MUTB_STRCM METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM-ALPHA)
>gi|538979|pir||B40595 methylmalonyl-CoA mutase (EC
5.4.99.2) mutB chain - Streptomyces cinnamonensis
>gi|153367|gb|AAA03041.1| (L10064) methylmalonyl-CoA
large subunit [Streptomyces cinnamonensis]
Length = 733
Score = 534 bits (1362), Expect = e-151
Identities = 272/524 (51%), Positives = 375/524 (70%), Gaps = 10/524 (1%)
Query: 39 TDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAE 98
T +G +K +YT AD+ E D+LE +PG P+ RG Y TMY + WT+RQYAG++TAE
Sbjct: 43 TPEGIAVKPLYTGADV-EGLDFLET--YPGVAPYLRGPYPTMYVNQPWTIRQYAGFSTAE 99
Query: 99 ESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGI 158
ESN Y+ L+ GQ GLSVAFDLPT GYDSDHP G+VG GVAIDS++DMR LFDGI
Sbjct: 100 ESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGI 159
Query: 159 PLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQP 218
PLDK++ SMT+N +LA+YI+ AEEQGVP EKL GT+QNDILKE++ R TYI+PP+P
Sbjct: 160 PLDKMTVSMTMNGAVLPVLALYIVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKP 219
Query: 219 SMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMD 278
SMR+ +DI Y ++ +P++N ISISGYHI+EAGA A E+A+TLADG+EY++A E G+D
Sbjct: 220 SMRIISDIFAYTSQKMPRYNSISISGYHIQEAGATADLELAYTLADGVEYLRAGQEAGLD 279
Query: 279 VDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGST 338
VD FAPRLSFF+A NF E+AK RAAR LWA ++K+ F+ KN +S+ LR H+QT+G +
Sbjct: 280 VDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWAKLVKQ-FDPKNAKSLSLRTHSQTSGWS 338
Query: 339 LTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESG 398
LTAQ NN+ R ++A+AA G TQSLHTN+ DEAL+LPT+ S RIA TQ +I ESG
Sbjct: 339 LTAQDVFNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLIQQESG 398
Query: 399 VVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQK 458
T+DP GG+ Y+E LT + A ++IE+++ GGM +AI+ G + + EAA + Q
Sbjct: 399 TTRTIDPWGGSAYVEKLTYDLARRAWQHIEEVEAAGGMAQAIDAGIPKLRVEEAAARTQA 458
Query: 459 EIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIERLKKLRSERDNKKVEEALDKL 517
I+ G++ ++GVNK+ D ++++LKVD S+R +QIE+L++LR ERD+ ++AL L
Sbjct: 459 RIDSGRQPVIGVNKYRVDTDEQIDVLKVDNSSVRAQQIEKLRRLREERDDAACQDALRAL 518
Query: 518 RNAAEKE-----DENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
AAE+ + NL+ ++A R AT+ E++D L ++G +
Sbjct: 519 TAAAERGPGQGLEGNLLALAVDAARAKATVGEISDALESVYGRH 562
>pir||D65076 sbm protein - Escherichia coli >gi|882446|gb|AAA69084.1| (U28377)
sbm gene product [Escherichia coli]
>gi|1789284|gb|AAC75954.1| (AE000375) methylmalonyl-CoA
mutase (MCM) [Escherichia coli K12]
Length = 714
Score = 533 bits (1359), Expect = e-150
Identities = 285/558 (51%), Positives = 382/558 (68%), Gaps = 17/558 (3%)
Query: 4 DVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEK 63
+V++ +++ +E E TV + + T +G IK +YT ADL D LE
Sbjct: 3 NVQEWQQLANKELSRREKTVDSLVHQ---------TAEGIAIKPLYTEADL----DNLEV 49
Query: 64 LG-FPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLP 122
G PG P+ RG ATMY + WT+RQYAG++TA+ESN Y+ L+ GQ GLSVAFDL
Sbjct: 50 TGTLPGLPPYVRGPRATMYTAQPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLA 109
Query: 123 TQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYIL 182
T GYDSD+P G+VGK GVAID++ DM++LFD IPLDK+S SMT+N +LA YI+
Sbjct: 110 THRGYDSDNPRVAGDVGKAGVAIDTVEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIV 169
Query: 183 VAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISI 242
AEEQGV +KL GT+QNDILKEY+ R TYI+PP+PSMR+ DII +C+ N+P++N ISI
Sbjct: 170 AAEEQGVTPDKLTGTIQNDILKEYLCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISI 229
Query: 243 SGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAK 302
SGYH+ EAGAN VQ+VAFTLADGIEY+KA I G+ +D FAPRLSFFF + +A
Sbjct: 230 SGYHMGEAGANCVQQVAFTLADGIEYIKAAISAGLKIDDFAPRLSFFFGIGMDLFMNVAM 289
Query: 303 FRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGG 362
RAAR LW+ + F A++P+S+ LR H QT+G +LT Q P NN+IR I+ALAA LGG
Sbjct: 290 LRAARYLWSEAV-SGFGAQDPKSLALRTHCQTSGWSLTEQDPYNNVIRTTIEALAATLGG 348
Query: 363 TQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEE 422
TQSLHTN++DEAL LPT+ S RIA TQ II ES + TVDPL G+YYIE LTD I ++
Sbjct: 349 TQSLHTNAFDEALGLPTDFSARIARNTQIIIQEESELCRTVDPLAGSYYIESLTDQIVKQ 408
Query: 423 ALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVE 482
A I++I + GGM +AIE G ++ I EA+ + Q I++GKR+IVGVNK+ D E +
Sbjct: 409 ARAIIQQIDEAGGMAKAIEAGLPKRMIEEASAREQSLIDQGKRVIVGVNKYKLDHEDETD 468
Query: 483 ILKVD-PSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLAT 541
+L++D +R++QI L+++R+ RD+ V AL+ L +AA+ +ENL+ + A R AT
Sbjct: 469 VLEIDNVMVRNEQIASLERIRATRDDAAVTAALNALTHAAQ-HNENLLAAAVNAARVRAT 527
Query: 542 LQEVTDVLREIWGEYRAP 559
L E++D L + Y P
Sbjct: 528 LGEISDALEVAFDRYLVP 545
>dbj|BAB06674.1| (AP001517) methylmalonyl-CoA mutase alpha subunit [Bacillus
halodurans]
Length = 716
Score = 533 bits (1358), Expect = e-150
Identities = 268/531 (50%), Positives = 374/531 (69%), Gaps = 5/531 (0%)
Query: 29 KAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTM 88
K+ E F T++ +K YT D+ G P PF RG Y TMY+ R WT+
Sbjct: 19 KSKEANVAFETNEQIPVKTFYTKEDIHGMKHLNYVAGIP---PFFRGPYPTMYKTRPWTI 75
Query: 89 RQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSL 148
RQYAG++TAEESN Y+ L+ GQ GLS+AFDL T GYDSDHP G+VGK GVA+DS+
Sbjct: 76 RQYAGFSTAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVVGDVGKAGVAVDSI 135
Query: 149 WDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIA 208
DM+ILFDGIPLD++S SMT+N ++A YI+ AEEQGV QE+L GT+QNDILKEY+
Sbjct: 136 LDMKILFDGIPLDQMSVSMTMNGAILPVMAFYIVAAEEQGVKQEQLTGTIQNDILKEYMV 195
Query: 209 RGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEY 268
R TYI+PP+ SM++ DI Y + +PK+N ISISGYH++EAGA A E+A+TLADG+EY
Sbjct: 196 RNTYIYPPEASMKVIADIFEYTSNYMPKFNSISISGYHMQEAGATADLELAYTLADGLEY 255
Query: 269 VKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMML 328
V+ ++ G+D+D FAPRLSFF+A N E+AK RAAR +WA +MK FN KNP+S+ L
Sbjct: 256 VRTGMKAGLDIDAFAPRLSFFWAIGMNHFMEVAKMRAARLIWAKLMKR-FNPKNPKSLAL 314
Query: 329 RFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALR 388
R H+QT+G +LT Q P NN++R ++ALAA LG TQSLHTN+ DEA++LPT+ S RIA
Sbjct: 315 RTHSQTSGWSLTEQDPYNNVVRTCVEALAAALGHTQSLHTNALDEAIALPTDFSARIARN 374
Query: 389 TQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKE 448
TQ + E+G+ + +DP GG+YY+E LT + ++A IE+I+++GGM +AI+ G +
Sbjct: 375 TQLYLQDETGITNVLDPWGGSYYVESLTAELLQKAWANIEEIEELGGMAKAIDTGLPKMR 434
Query: 449 IAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIERLKKLRSERDN 507
I EAA + Q +I+ GK I+GVNK+ D ++IL +D ++R+ QI RL+KL++ERD
Sbjct: 435 IEEAAARRQAKIDSGKEAIIGVNKYRPDTEEPLDILDIDNTAVREAQIRRLEKLKAERDE 494
Query: 508 KKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEYRA 558
++V++AL+++ AAE E ENL+ +EA R A+L E++ ++ G ++A
Sbjct: 495 ERVQQALNRITKAAETEKENLLTCAVEAARARASLGEISMAYEKVVGRHKA 545
>sp|P27253|SBM_ECOLI SBM PROTEIN >gi|96094|pir||S22099 sbm protein - Escherichia coli
>gi|42945|emb|CAA47311.1| (X66836) sbm orf [Escherichia
coli]
Length = 714
Score = 532 bits (1356), Expect = e-150
Identities = 285/558 (51%), Positives = 381/558 (68%), Gaps = 17/558 (3%)
Query: 4 DVEKLKKIKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEK 63
+V++ +++ +E E TV + + T +G IK +YT ADL D LE
Sbjct: 3 NVQEWQQLANKELSRREKTVDSLVHQ---------TAEGIAIKPLYTEADL----DNLEV 49
Query: 64 LG-FPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLP 122
G PG P+ RG ATMY + WT+RQYAG++TA+ESN Y+ L+ GQ GLSVAFDL
Sbjct: 50 TGTLPGLPPYVRGPRATMYTAQPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLA 109
Query: 123 TQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYIL 182
T GYDSD+P G+VGK GVAID++ DM++LFD IPLDK+S SMT+N +LA YI+
Sbjct: 110 THRGYDSDNPRVAGDVGKAGVAIDTVEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIV 169
Query: 183 VAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISI 242
AEEQGV +KL GT+QNDILKEY+ R TYI+PP+PSMR+ DII +C+ N+P++N ISI
Sbjct: 170 AAEEQGVTPDKLTGTIQNDILKEYLCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISI 229
Query: 243 SGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAK 302
SGYH+ EAGAN VQ+VAFTLADGIEY+KA I G+ +D FAPRLSFFF + +A
Sbjct: 230 SGYHMGEAGANCVQQVAFTLADGIEYIKAAISAGLKIDDFAPRLSFFFGIGMDLFMNVAM 289
Query: 303 FRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGG 362
RAAR LW+ + F A++P+S+ LR H QT+G +LT Q P NN+IR I+ALAA LGG
Sbjct: 290 LRAARYLWSEAV-SGFGAQDPKSLALRTHCQTSGWSLTEQDPYNNVIRTTIEALAATLGG 348
Query: 363 TQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEE 422
TQSLHTN +DEAL LPT+ S RIA TQ II ES + TVDPL G+YYIE LTD I ++
Sbjct: 349 TQSLHTNVFDEALGLPTDFSARIARNTQIIIQEESELCRTVDPLAGSYYIESLTDQIVKQ 408
Query: 423 ALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVE 482
A I++I + GGM +AIE G ++ I EA+ + Q I++GKR+IVGVNK+ D E +
Sbjct: 409 ARAIIQQIDEAGGMAKAIEAGLPKRMIEEASAREQSLIDQGKRVIVGVNKYKLDHEDETD 468
Query: 483 ILKVD-PSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLAT 541
+L++D +R++QI L+++R+ RD+ V AL+ L +AA+ +ENL+ + A R AT
Sbjct: 469 VLEIDNVMVRNEQIASLERIRATRDDAAVTAALNALTHAAQ-HNENLLAAAVNAARVRAT 527
Query: 542 LQEVTDVLREIWGEYRAP 559
L E++D L + Y P
Sbjct: 528 LGEISDALEVAFDRYLVP 545
>pir||T43706 isobutyryl-CoA mutase (EC 5.4.99.13) chain A [similarity] -
Streptomyces coelicolor >gi|4585853|emb|CAB40912.1|
(AJ237976) isobutyryl-CoA mutase A [Streptomyces
coelicolor] >gi|6808408|emb|CAB70645.1| (AL137242)
isobutyryl-coA mutase A [Streptomyces coelicolor A3(2)]
Length = 566
Score = 531 bits (1353), Expect = e-150
Identities = 274/568 (48%), Positives = 379/568 (66%), Gaps = 23/568 (4%)
Query: 11 IKEEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEY 70
I+E RW+ + A +R F T G ++ +Y P G+ ++ E++G+PGEY
Sbjct: 6 IEEGRLRWQAR-----YDAARKRDADFTTLSGDPVEPVYGPRP-GDEYEGFERIGWPGEY 59
Query: 71 PFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSD 130
PFTRG+Y T YRGR WT+RQ+AG+ AE++N+RYK +L G GLSVAFD+PT +G DSD
Sbjct: 60 PFTRGLYPTGYRGRTWTIRQFAGFGNAEQTNERYKMILRNGGGGLSVAFDMPTLMGRDSD 119
Query: 131 HPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVP 190
P + GEVG GVAIDS DM +LF IPL V+TSMTI+ A + MY++ AE QGV
Sbjct: 120 DPRSLGEVGHCGVAIDSAADMEVLFKDIPLGDVTTSMTISGPAVPVFCMYLVAAERQGVD 179
Query: 191 QEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREA 250
L GT+Q DI KEYIA+ ++F P+P +RL D++ YCA +P + P+S+SGYHIREA
Sbjct: 180 ASVLNGTLQTDIFKEYIAQKEWLFQPEPHLRLIGDLMEYCAAGIPAYKPLSVSGYHIREA 239
Query: 251 GANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLW 310
GA A QE+A+TLADG YV+ + RG+DVD FAP LSFFF AH +F EEIAKFRAARR+W
Sbjct: 240 GATAAQELAYTLADGFGYVELGLSRGLDVDVFAPGLSFFFDAHLDFFEEIAKFRAARRIW 299
Query: 311 AYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNS 370
A M++ + A+ ++ LRFHTQTAG +LTAQQP NN++R A++ALAAVLGGT SLHTN+
Sbjct: 300 ARWMRDVYGARTDKAQWLRFHTQTAGVSLTAQQPYNNVVRTAVEALAAVLGGTNSLHTNA 359
Query: 371 YDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKI 430
DE L+LP+E++ IALRTQQ++ E+GV + DPLGG+++IE LTD I +A K E+I
Sbjct: 360 LDETLALPSEQAAEIALRTQQVLMEETGVANVADPLGGSWFIEQLTDRIEADAEKIFEQI 419
Query: 431 QKMG----------------GMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFV 474
++ G G++R IE G+ EIAE+A++YQ+ +E+ + +VGVN
Sbjct: 420 KERGLRAHPDGQHPVGPITSGLLRGIEDGWFTGEIAESAFRYQQSLEKDDKKVVGVNVHT 479
Query: 475 TDEPIEVEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIE 534
++EIL+V + +Q+ L + + RD+ V ALD + AA + N++ +++
Sbjct: 480 GSVTGDLEILRVSHEVEREQVRVLGERKDARDDAAVRGALDAML-AAARSGGNMIGPMLD 538
Query: 535 AHRHLATLQEVTDVLREIWGEYRAPLIF 562
A R ATL E+ VLR+ WG Y P F
Sbjct: 539 AVRAEATLGEICGVLRDEWGVYTEPAGF 566
>pir||S40622 methylmalonyl CoA mutase precursor - human
Length = 742
Score = 528 bits (1346), Expect = e-149
Identities = 275/542 (50%), Positives = 368/542 (67%), Gaps = 15/542 (2%)
Query: 18 WEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVY 77
W K+ K PE + T +G IK +Y+ D D E+L PG PFTRG Y
Sbjct: 43 WAALAKKQLKGKNPEDLI-WHTPEGISIKPLYSKRD---TMDLPEEL--PGVKPFTRGPY 96
Query: 78 ATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGE 137
TMY R WT+RQYAG++T EESNK YK + GQ GLSVAFDL T GYDSD+P G+
Sbjct: 97 PTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRLRGD 156
Query: 138 VGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGT 197
VG GVAID++ D +ILFDGIPL+K+S SMT+N +LA +I+ EEQGVP+EKL GT
Sbjct: 157 VGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGT 216
Query: 198 VQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQE 257
+QNDILKE++ R TYIFPP PSM++ DI Y A+++PK+N ISISGYH++EAGA+A+ E
Sbjct: 217 IQNDILKEFMVRNTYIFPPDPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILE 276
Query: 258 VAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEW 317
+A+TLADG+EY + ++ G+ +D+FAPRLSFF+ NF EIAK RA RRLWA+++++
Sbjct: 277 LAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFHMEIAKMRAGRRLWAHLIEKM 336
Query: 318 FNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSL 377
F KN +S++LR H QT+G +LT Q P NNI+R AI+A+AAV GGTQSLHTNS+DEAL L
Sbjct: 337 FQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGL 396
Query: 378 PTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMM 437
PT KS RIA TQ II ESG+ DP GG+Y +E LT K I +I++MGGM
Sbjct: 397 PTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLT--------KLINEIEEMGGMA 448
Query: 438 RAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIE 496
+A+ G + I E A + Q I+ G +IVGVNK+ ++ VE+L D S+R++QI
Sbjct: 449 KAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDAVEVLATDNTSVRNRQIG 508
Query: 497 RLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEY 556
+LKK++S RD E L L A D N++ ++A R T+ E+TD L++++GE+
Sbjct: 509 KLKKIKSSRDQALAEHCLAALTECAASGDGNILALAVDASRARCTVGEITDALKKVFGEH 568
Query: 557 RA 558
+A
Sbjct: 569 KA 570
>sp|P11653|MUTB_PROFR METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM-ALPHA)
>gi|80621|pir||S04641 methylmalonyl-CoA mutase (EC
5.4.99.2) alpha chain - Propionibacterium freudenreichii
subsp. shermanii >gi|581476|emb|CAA33090.1| (X14965)
mutB product, methylmalonyl-CoA mutase alpha-subunit (AA
1-728) [Propionibacterium freudenreichii subsp.
shermanii]
Length = 728
Score = 511 bits (1302), Expect = e-144
Identities = 269/551 (48%), Positives = 377/551 (67%), Gaps = 16/551 (2%)
Query: 16 KRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRG 75
+R+EE K +A E E+ F D+ ++ D+L+ + G PF G
Sbjct: 23 RRFEELAAKAGTGEAWETAEQIPVGTLFN-------EDVYKDMDWLDT--YAGIPPFVHG 73
Query: 76 VYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAE 135
YATMY R WT+RQYAG++TA+ESN Y+ L+ GQ GLSVAFDLPT GYDSD+P
Sbjct: 74 PYATMYAFRPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVA 133
Query: 136 GEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLR 195
G+VG GVAIDS++DMR LF GIPLD++S SMT+N +LA+Y++ AEEQGV E+L
Sbjct: 134 GDVGMAGVAIDSIYDMRELFAGIPLDQMSVSMTMNGAVLPILALYVVTAEEQGVKPEQLA 193
Query: 196 GTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAV 255
GT+QNDILKE++ R TYI+PPQPSMR+ ++I Y + N+PKWN ISISGYH++EAGA A
Sbjct: 194 GTIQNDILKEFMVRNTYIYPPQPSMRIISEIFAYTSANMPKWNSISISGYHMQEAGATAD 253
Query: 256 QEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMK 315
E+A+TLADG++Y++A G++VD+FAPRLSFF+ NF E+AK RAAR LWA ++
Sbjct: 254 IEMAYTLADGVDYIRAGESVGLNVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVH 313
Query: 316 EWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEAL 375
+ F KNP+SM LR H+QT+G +LTAQ NN++R I+A+AA G TQSLHTNS DEA+
Sbjct: 314 Q-FGPKNPKSMSLRTHSQTSGWSLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAI 372
Query: 376 SLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGG 435
+LPT+ S RIA TQ + ESG +DP G+ Y+E LT + +A +I++++K+GG
Sbjct: 373 ALPTDFSARIARNTQLFLQQESGTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVGG 432
Query: 436 MMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVDPS-IRDKQ 494
M +AIE+G + I EAA + Q I+ G++ ++GVNK+ + +++LKVD S + +Q
Sbjct: 433 MAKAIEKGIPKMRIEEAAARTQARIDSGRQPLIGVNKYRLEHEPPLDVLKVDNSTVLAEQ 492
Query: 495 IERLKKLRSERDNKKVEEALDKLRNAA-----EKEDENLMPYIIEAHRHLATLQEVTDVL 549
+L KLR+ERD +KV+ ALDK+ AA + D NL+ I+A R +AT+ E++D L
Sbjct: 493 KAKLVKLRAERDPEKVKAALDKITWAAGNPDDKDPDRNLLKLCIDAGRAMATVGEMSDAL 552
Query: 550 REIWGEYRAPL 560
+++G Y A +
Sbjct: 553 EKVFGRYTAQI 563
>pdb|6REQ|A Chain A, Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Coa Inhibitor
Complex >gi|3660443|pdb|6REQ|C Chain C,
Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Coa Inhibitor
Complex >gi|4389055|pdb|4REQ|A Chain A,
Methylmalonyl-Coa Mutase Substrate Complex
>gi|4389057|pdb|4REQ|C Chain C, Methylmalonyl-Coa Mutase
Substrate Complex >gi|1942488|pdb|1REQ|A Chain A,
Methylmalonyl-Coa Mutase >gi|1942490|pdb|1REQ|C Chain C,
Methylmalonyl-Coa Mutase >gi|2914199|pdb|2REQ|A Chain A,
Methylmalonyl-Coa Mutase, Non-Productive Coa Complex, In
Open Conformation Representing Substrate-Free State
>gi|2914201|pdb|2REQ|C Chain C, Methylmalonyl-Coa
Mutase, Non-Productive Coa Complex, In Open Conformation
Representing Substrate-Free State >gi|2981906|pdb|3REQ|A
Chain A, Methylmalonyl-Coa Mutase, Substrate-Free State
(Poor Quality Structure) >gi|3660449|pdb|7REQ|A Chain A,
Methylmalonyl-Coa Mutase, 2-Carboxypropyl-Coa Inhibitor
Complex >gi|3660451|pdb|7REQ|C Chain C,
Methylmalonyl-Coa Mutase, 2-Carboxypropyl-Coa Inhibitor
Complex
Length = 727
Score = 511 bits (1302), Expect = e-144
Identities = 269/551 (48%), Positives = 377/551 (67%), Gaps = 16/551 (2%)
Query: 16 KRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRG 75
+R+EE K +A E E+ F D+ ++ D+L+ + G PF G
Sbjct: 22 RRFEELAAKAGTGEAWETAEQIPVGTLFN-------EDVYKDMDWLDT--YAGIPPFVHG 72
Query: 76 VYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAE 135
YATMY R WT+RQYAG++TA+ESN Y+ L+ GQ GLSVAFDLPT GYDSD+P
Sbjct: 73 PYATMYAFRPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVA 132
Query: 136 GEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLR 195
G+VG GVAIDS++DMR LF GIPLD++S SMT+N +LA+Y++ AEEQGV E+L
Sbjct: 133 GDVGMAGVAIDSIYDMRELFAGIPLDQMSVSMTMNGAVLPILALYVVTAEEQGVKPEQLA 192
Query: 196 GTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAV 255
GT+QNDILKE++ R TYI+PPQPSMR+ ++I Y + N+PKWN ISISGYH++EAGA A
Sbjct: 193 GTIQNDILKEFMVRNTYIYPPQPSMRIISEIFAYTSANMPKWNSISISGYHMQEAGATAD 252
Query: 256 QEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMK 315
E+A+TLADG++Y++A G++VD+FAPRLSFF+ NF E+AK RAAR LWA ++
Sbjct: 253 IEMAYTLADGVDYIRAGESVGLNVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVH 312
Query: 316 EWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEAL 375
+ F KNP+SM LR H+QT+G +LTAQ NN++R I+A+AA G TQSLHTNS DEA+
Sbjct: 313 Q-FGPKNPKSMSLRTHSQTSGWSLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAI 371
Query: 376 SLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGG 435
+LPT+ S RIA TQ + ESG +DP G+ Y+E LT + +A +I++++K+GG
Sbjct: 372 ALPTDFSARIARNTQLFLQQESGTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVGG 431
Query: 436 MMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVDPS-IRDKQ 494
M +AIE+G + I EAA + Q I+ G++ ++GVNK+ + +++LKVD S + +Q
Sbjct: 432 MAKAIEKGIPKMRIEEAAARTQARIDSGRQPLIGVNKYRLEHEPPLDVLKVDNSTVLAEQ 491
Query: 495 IERLKKLRSERDNKKVEEALDKLRNAA-----EKEDENLMPYIIEAHRHLATLQEVTDVL 549
+L KLR+ERD +KV+ ALDK+ AA + D NL+ I+A R +AT+ E++D L
Sbjct: 492 KAKLVKLRAERDPEKVKAALDKITWAAGNPDDKDPDRNLLKLCIDAGRAMATVGEMSDAL 551
Query: 550 REIWGEYRAPL 560
+++G Y A +
Sbjct: 552 EKVFGRYTAQI 562
>pdb|5REQ|A Chain A, Methylmalonyl-Coa Mutase, Y89f Mutant, Substrate Complex
>gi|7546643|pdb|5REQ|C Chain C, Methylmalonyl-Coa
Mutase, Y89f Mutant, Substrate Complex
Length = 727
Score = 510 bits (1298), Expect = e-143
Identities = 268/551 (48%), Positives = 377/551 (67%), Gaps = 16/551 (2%)
Query: 16 KRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRG 75
+R+EE K +A E E+ F D+ ++ D+L+ + G PF G
Sbjct: 22 RRFEELAAKAGTGEAWETAEQIPVGTLFN-------EDVYKDMDWLDT--YAGIPPFVHG 72
Query: 76 VYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAE 135
YATMY R WT+RQ+AG++TA+ESN Y+ L+ GQ GLSVAFDLPT GYDSD+P
Sbjct: 73 PYATMYAFRPWTIRQFAGFSTAKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVA 132
Query: 136 GEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLR 195
G+VG GVAIDS++DMR LF GIPLD++S SMT+N +LA+Y++ AEEQGV E+L
Sbjct: 133 GDVGMAGVAIDSIYDMRELFAGIPLDQMSVSMTMNGAVLPILALYVVTAEEQGVKPEQLA 192
Query: 196 GTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAV 255
GT+QNDILKE++ R TYI+PPQPSMR+ ++I Y + N+PKWN ISISGYH++EAGA A
Sbjct: 193 GTIQNDILKEFMVRNTYIYPPQPSMRIISEIFAYTSANMPKWNSISISGYHMQEAGATAD 252
Query: 256 QEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMK 315
E+A+TLADG++Y++A G++VD+FAPRLSFF+ NF E+AK RAAR LWA ++
Sbjct: 253 IEMAYTLADGVDYIRAGESVGLNVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVH 312
Query: 316 EWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEAL 375
+ F KNP+SM LR H+QT+G +LTAQ NN++R I+A+AA G TQSLHTNS DEA+
Sbjct: 313 Q-FGPKNPKSMSLRTHSQTSGWSLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAI 371
Query: 376 SLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGG 435
+LPT+ S RIA TQ + ESG +DP G+ Y+E LT + +A +I++++K+GG
Sbjct: 372 ALPTDFSARIARNTQLFLQQESGTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVGG 431
Query: 436 MMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVDPS-IRDKQ 494
M +AIE+G + I EAA + Q I+ G++ ++GVNK+ + +++LKVD S + +Q
Sbjct: 432 MAKAIEKGIPKMRIEEAAARTQARIDSGRQPLIGVNKYRLEHEPPLDVLKVDNSTVLAEQ 491
Query: 495 IERLKKLRSERDNKKVEEALDKLRNAA-----EKEDENLMPYIIEAHRHLATLQEVTDVL 549
+L KLR+ERD +KV+ ALDK+ AA + D NL+ I+A R +AT+ E++D L
Sbjct: 492 KAKLVKLRAERDPEKVKAALDKITWAAGNPDDKDPDRNLLKLCIDAGRAMATVGEMSDAL 551
Query: 550 REIWGEYRAPL 560
+++G Y A +
Sbjct: 552 EKVFGRYTAQI 562
>pdb|1E1C|A Chain A, Methylmalonyl-Coa Mutase H244a Mutant
>gi|8569649|pdb|1E1C|C Chain C, Methylmalonyl-Coa Mutase
H244a Mutant
Length = 727
Score = 507 bits (1292), Expect = e-142
Identities = 268/551 (48%), Positives = 376/551 (67%), Gaps = 16/551 (2%)
Query: 16 KRWEETTVKKFLEKAPERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRG 75
+R+EE K +A E E+ F D+ ++ D+L+ + G PF G
Sbjct: 22 RRFEELAAKAGTGEAWETAEQIPVGTLFN-------EDVYKDMDWLDT--YAGIPPFVHG 72
Query: 76 VYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAE 135
YATMY R WT+RQYAG++TA+ESN Y+ L+ GQ GLSVAFDLPT GYDSD+P
Sbjct: 73 PYATMYAFRPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVA 132
Query: 136 GEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLR 195
G+VG GVAIDS++DMR LF GIPLD++S SMT+N +LA+Y++ AEEQGV E+L
Sbjct: 133 GDVGMAGVAIDSIYDMRELFAGIPLDQMSVSMTMNGAVLPILALYVVTAEEQGVKPEQLA 192
Query: 196 GTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAV 255
GT+QNDILKE++ R TYI+PPQPSMR+ ++I Y + N+PKWN ISISGY ++EAGA A
Sbjct: 193 GTIQNDILKEFMVRNTYIYPPQPSMRIISEIFAYTSANMPKWNSISISGYAMQEAGATAD 252
Query: 256 QEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMK 315
E+A+TLADG++Y++A G++VD+FAPRLSFF+ NF E+AK RAAR LWA ++
Sbjct: 253 IEMAYTLADGVDYIRAGESVGLNVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVH 312
Query: 316 EWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEAL 375
+ F KNP+SM LR H+QT+G +LTAQ NN++R I+A+AA G TQSLHTNS DEA+
Sbjct: 313 Q-FGPKNPKSMSLRTHSQTSGWSLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAI 371
Query: 376 SLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGG 435
+LPT+ S RIA TQ + ESG +DP G+ Y+E LT + +A +I++++K+GG
Sbjct: 372 ALPTDFSARIARNTQLFLQQESGTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVGG 431
Query: 436 MMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEVEILKVDPS-IRDKQ 494
M +AIE+G + I EAA + Q I+ G++ ++GVNK+ + +++LKVD S + +Q
Sbjct: 432 MAKAIEKGIPKMRIEEAAARTQARIDSGRQPLIGVNKYRLEHEPPLDVLKVDNSTVLAEQ 491
Query: 495 IERLKKLRSERDNKKVEEALDKLRNAA-----EKEDENLMPYIIEAHRHLATLQEVTDVL 549
+L KLR+ERD +KV+ ALDK+ AA + D NL+ I+A R +AT+ E++D L
Sbjct: 492 KAKLVKLRAERDPEKVKAALDKITWAAGNPDDKDPDRNLLKLCIDAGRAMATVGEMSDAL 551
Query: 550 REIWGEYRAPL 560
+++G Y A +
Sbjct: 552 EKVFGRYTAQI 562
>sp|Q59677|MUTA_PORGI METHYLMALONYL-COA MUTASE BETA-SUBUNIT (MCB-BETA)
>gi|2126435|pir||JC4560 methylmalonyl-CoA mutase (EC
5.4.99.2) large chain - Porphyromonas gingivalis
>gi|463175|gb|AAB51084.1| (L30136) methylmalonyl-CoA
mutase beta-subunit [Porphyromonas gingivalis]
>gi|1586535|prf||2204234B methylmalonyl-CoA
mutase:SUBUNIT=large [Porphyromonas gingivalis]
Length = 715
Score = 500 bits (1274), Expect = e-140
Identities = 266/523 (50%), Positives = 361/523 (68%), Gaps = 9/523 (1%)
Query: 39 TDDGFEIKRIYTPADLG--ENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYAT 96
T + +K +YT DL E+ DY+ G P PF RG Y+ MY R WT+RQYAG++T
Sbjct: 35 TPEQIMVKPLYTKDDLEGMEHLDYVS--GLP---PFLRGPYSGMYPMRPWTIRQYAGFST 89
Query: 97 AEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFD 156
AEESN Y+ L+ GQ GLSVAFDL T GYD+DH G+VGK GV+I SL DM++LFD
Sbjct: 90 AEESNAFYRRNLASGQKGLSVAFDLATHRGYDADHSRVVGDVGKAGVSICSLEDMKVLFD 149
Query: 157 GIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPP 216
GIPL K+S SMT+N +LA YI EQG E++ GT+QNDILKE++ R TYI+PP
Sbjct: 150 GIPLSKMSVSMTMNGAVLPILAFYINAGLEQGAKLEEMAGTIQNDILKEFMVRNTYIYPP 209
Query: 217 QPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERG 276
+ SMR+ DI Y ++N+PK+N ISISGYH++EAGA A E+A+TLADG++Y+KA I+ G
Sbjct: 210 EFSMRIIADIFEYTSQNMPKFNSISISGYHMQEAGATADIEMAYTLADGMQYLKAGIDAG 269
Query: 277 MDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAG 336
+DVD FAPRLSFF+A N EIAK RAAR LWA I+K F AKNP+S+ LR H+QT+G
Sbjct: 270 IDVDAFAPRLSFFWAIGVNHFMEIAKMRAARLLWAKIVKS-FGAKNPKSLALRTHSQTSG 328
Query: 337 STLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYE 396
+LT Q P NN+ R I+A+AA LG TQSLHTN+ DEA++LPT+ S RIA TQ I E
Sbjct: 329 WSLTEQDPFNNVGRTCIEAMAAALGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQEE 388
Query: 397 SGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKY 456
+ V +DP GG+YY+E LT+ + +A I+++Q+MGGM +AIE G + I EAA +
Sbjct: 389 TLVCKEIDPWGGSYYVESLTNELVHKAWTLIKEVQEMGGMAKAIETGLPKLRIEEAAART 448
Query: 457 QKEIEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIERLKKLRSERDNKKVEEALD 515
Q I+ +++IVGVNK+ + ++IL++D ++R +QIERL LRS RD K V+EAL+
Sbjct: 449 QARIDSHQQVIVGVNKYRLPKEDPIDILEIDNTAVRKQQIERLNDLRSHRDEKAVQEALE 508
Query: 516 KLRNAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEYRA 558
+ E ++ NL+ ++A A+L E++D ++ G Y+A
Sbjct: 509 AITKCVETKEGNLLDLAVKAAGLRASLGEISDACEKVVGRYKA 551
>sp|P71774|MUTB_MYCTU PROBABLE METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM)
>gi|7478453|pir||H70711 probable mutB protein -
Mycobacterium tuberculosis (strain H37RV)
>gi|1524240|emb|CAB02043.1| (Z79701) mutB [Mycobacterium
tuberculosis]
Length = 750
Score = 500 bits (1274), Expect = e-140
Identities = 257/532 (48%), Positives = 358/532 (66%), Gaps = 11/532 (2%)
Query: 39 TDDGFEIKRIYTPAD-LGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATA 97
T +G ++ +Y AD + FPGE PF RG Y TMY + WT+RQYAG++TA
Sbjct: 52 TPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQYAGFSTA 111
Query: 98 EESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDG 157
+SN Y+ L+ GQ GLSVAFDL T GYDSDHP +G+VG GVAIDS+ DMR LFDG
Sbjct: 112 ADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDG 171
Query: 158 IPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQ 217
I L VS SMT+N +LA+Y++ AEEQGV E+L GT+QNDILKE++ R TYI+PP+
Sbjct: 172 IDLSTVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPK 231
Query: 218 PSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGM 277
PSMR+ +DI Y + +PK+N ISISGYHI+EAGA A E+A+TLADG++Y++A + G+
Sbjct: 232 PSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIRAGLNAGL 291
Query: 278 DVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGS 337
D+D FAPRLSFF+ NF E+AK RA R LW+ ++ + F K+ +S+ LR H+QT+G
Sbjct: 292 DIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQ-FAPKSAKSLSLRTHSQTSGW 350
Query: 338 TLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYES 397
+LTAQ NN+ R I+A+AA G TQSLHTN+ DEAL+LPT+ S RIA TQ ++ ES
Sbjct: 351 SLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQES 410
Query: 398 GVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQ 457
G +DP GG+YY+EWLT + A +I ++ + GGM +AI G + I EAA + Q
Sbjct: 411 GTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQ 470
Query: 458 KEIEEGKRIIVGVNKFVTDEPIEVEILKVDPS-IRDKQIERLKKLRSERDNKKVEEALDK 516
I+ G++ +VGVNK+ E E+E+LKV+ S +R +Q+ +L++LR+ RD V AL +
Sbjct: 471 ARIDSGQQPVVGVNKYQVPEDHEIEVLKVENSRVRAEQLAKLQRLRAGRDEPAVRAALAE 530
Query: 517 LRNAAEKE--------DENLMPYIIEAHRHLATLQEVTDVLREIWGEYRAPL 560
L AA ++ NL+ I+A R AT+ E+++ L +++G +RA +
Sbjct: 531 LTRAAAEQGRAGADGLGNNLLALAIDAARAQATVGEISEALEKVYGRHRAEI 582
>pir||T35959 methylmalonyl-CoA mutase, coenzyme B12-dependent - Streptomyces
coelicolor >gi|4154067|emb|CAA22720.1| (AL035161)
coenzyme B12-dependent mutase [Streptomyces coelicolor
A3(2)]
Length = 675
Score = 397 bits (1008), Expect = e-109
Identities = 217/497 (43%), Positives = 313/497 (62%), Gaps = 19/497 (3%)
Query: 81 YRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGK 140
++ R W MR YAG++TAE SN+ Y+ L++GQTGLSVAFDLPTQ GYDSDH LA GEVG+
Sbjct: 5 HKDRPWLMRTYAGHSTAEASNELYRRNLAKGQTGLSVAFDLPTQTGYDSDHVLARGEVGR 64
Query: 141 VGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQN 200
VGV + L DMR LF IPL++++TSMTINATA LLA+Y +VAEEQG KL+GT QN
Sbjct: 65 VGVPVAHLGDMRRLFQDIPLEQMNTSMTINATAMWLLALYQVVAEEQGADLTKLQGTTQN 124
Query: 201 DILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAF 260
DI+KEY++RGT++FPP PS+RLTTD+I Y ++PKWNPI+I YH++EAGA VQE+A+
Sbjct: 125 DIVKEYLSRGTHVFPPGPSLRLTTDMIAYTVSHLPKWNPINICSYHLQEAGATPVQEIAY 184
Query: 261 TLADGIEYVKAVIERGM----DVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKE 316
++ I + AV + G + R+SFF A F+EE+ K RA R+W + +E
Sbjct: 185 AMSTAIAVLDAVRDSGQVPQERMGDVVGRISFFVNAGVRFVEEMCKMRAFGRIWDRVTRE 244
Query: 317 WFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVL---GGTQSLHTNSYDE 373
+ +NP+ R+ Q LT QPENN+ R+ ++ LA L +++ +++E
Sbjct: 245 RYGIENPKHRRFRYGVQVNSLGLTEAQPENNVQRIVLEMLAVTLSKDARARAVQLPAWNE 304
Query: 374 ALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKM 433
AL LP + +LR QQ++A+ES +++ D G+ +E D + E A IE+IQ+M
Sbjct: 305 ALGLPRPWDQQWSLRIQQVLAHESDLLEYEDLFEGSKVVEAKVDELVEAAFAEIERIQEM 364
Query: 434 GGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEP------IEVEILKVD 487
GG M A+E GY++ ++ + + + IE G+ I+GVN F EP ++ I VD
Sbjct: 365 GGAMAAVESGYLKSQLVASHAERRARIESGEEKIIGVNAFEGTEPNPLTADLDTAIQTVD 424
Query: 488 PSIRDKQIERLKKLRSER-----DNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATL 542
P++ + I L+ R R ++ + +AL+KL+ AA + NLM +E R AT
Sbjct: 425 PAVEARVIASLQSWRDTRYQPPFNHPRPCKALEKLKEAA-RGTGNLMEATLECARAGATT 483
Query: 543 QEVTDVLREIWGEYRAP 559
E LRE++GE+RAP
Sbjct: 484 GEWAGALREVFGEFRAP 500
>gb|AAC45598.1| (AF008569) coenzyme B12-dependent mutase [Streptomyces collinus]
Length = 674
Score = 391 bits (993), Expect = e-107
Identities = 213/496 (42%), Positives = 310/496 (61%), Gaps = 19/496 (3%)
Query: 82 RGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKV 141
+ R W MR YAG++TA SN+ Y+ L++GQTGLSVAFDLPTQ GYD DH LA GEVG+V
Sbjct: 6 KDRPWLMRTYAGHSTAAVSNELYRRNLAKGQTGLSVAFDLPTQTGYDPDHILARGEVGRV 65
Query: 142 GVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQND 201
GV + L DM LF IPL++++TSMTINATA LLA+Y +VAEEQG KL+GT QND
Sbjct: 66 GVPVAHLGDMCRLFQDIPLEQMNTSMTINATAMWLLALYQVVAEEQGADITKLQGTTQND 125
Query: 202 ILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFT 261
I+KEY++RGT++FPP PS+RLTTD+I Y ++PKWNPI+I YH++EAGA VQE+A+
Sbjct: 126 IVKEYLSRGTHVFPPGPSLRLTTDMIAYTCSHIPKWNPINICSYHLQEAGATPVQEIAYA 185
Query: 262 LADGIEYVKAVIERGM----DVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEW 317
++ I + AV + G + R+SFF A F+EE+ K RA R+W + +E
Sbjct: 186 MSTAIAVLDAVRDSGQVPQERMGDVVARISFFVNAGVRFIEEMCKMRAFGRIWDKVTRER 245
Query: 318 FNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVL---GGTQSLHTNSYDEA 374
+ +NP+ R+ Q LT QPENN+ R+ ++ LA L +++ +++EA
Sbjct: 246 YGIENPKQRRFRYGVQVTSLGLTEAQPENNVQRIVLEMLAVTLSKDARARAVQLPAWNEA 305
Query: 375 LSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMG 434
L LP + +LR QQ++AYES +++ D G+ IE D + + L +++IQ+MG
Sbjct: 306 LGLPRPWDQQWSLRIQQVLAYESDLLEYEDIFEGSKVIEAKVDQLVTDVLAEMDRIQEMG 365
Query: 435 GMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEP------IEVEILKVDP 488
G M A+E GY++ ++ + + + IE G+ IVGVN F EP ++ I VDP
Sbjct: 366 GAMAAVESGYLKSQLVASHAERRARIESGQEKIVGVNVFEGTEPNPLTADLDTAIQTVDP 425
Query: 489 SIRDKQIERLKKLRSER-----DNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQ 543
++ ++ +E L+ R ++ + +AL++L+ AA K +NLM +E R T
Sbjct: 426 AVENRVVESLRHWRDTPYQPPFNHPRPCKALERLKEAA-KGTDNLMEATLECARAGVTTG 484
Query: 544 EVTDVLREIWGEYRAP 559
E LRE++GEYRAP
Sbjct: 485 EWAGALREVFGEYRAP 500
>sp|Q49115|MEAA_METEX MEAA PROTEIN >gi|1098584|gb|AAC44087.1| (U28335) MeaA
[Methylobacterium extorquens]
Length = 688
Score = 384 bits (975), Expect = e-105
Identities = 213/495 (43%), Positives = 311/495 (62%), Gaps = 15/495 (3%)
Query: 78 ATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGE 137
A + R + W +R YAG++TA ESNK Y+ L++GQTGLSVAFDLPTQ GYD DH LA GE
Sbjct: 8 AEVKRDKPWIIRTYAGHSTAAESNKLYRGNLAKGQTGLSVAFDLPTQTGYDPDHELARGE 67
Query: 138 VGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGT 197
VGKVGV+I L DMR LFD IPL +++TSMTINATA LL++Y+ VAEEQG P L+GT
Sbjct: 68 VGKVGVSIAHLGDMRALFDQIPLAQMNTSMTINATAPWLLSLYLAVAEEQGAPLAALQGT 127
Query: 198 VQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQE 257
QNDI+KEY++RGTY+FPP PS+RLT D+I++ +NVPKWNP+++ YH++EAGA VQE
Sbjct: 128 TQNDIIKEYLSRGTYVFPPAPSLRLTKDVILFTTKNVPKWNPMNVCSYHLQEAGATPVQE 187
Query: 258 VAFTLADGIEYVKAV-----IERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAY 312
+++ LA I + V + D F+ R+SFF A F+ EI K RA LW
Sbjct: 188 LSYALAIAIAVLDTVRDDPDFDEASFSDVFS-RISFFVNAGMRFVTEICKMRAFAELWDE 246
Query: 313 IMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVL---GGTQSLHTN 369
I +E + + + + R+ Q LT QQPENN+ R+ I+ LA L +++
Sbjct: 247 IAQERYGITDAKKRIFRYGVQVNSLGLTEQQPENNVHRILIEMLAVTLSKRARARAVQLP 306
Query: 370 SYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEK 429
+++EAL LP + ++R QQI+A+E+ +++ D G+ IE + + E+ + +
Sbjct: 307 AWNEALGLPRPWDQQWSMRMQQILAFETDLLEYDDIFDGSTVIEARVEALKEQTRAELTR 366
Query: 430 IQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVTDEPIEV-----EIL 484
I ++GG + A+E G +++ + E+ + IE+G++I+VGVNK+ EP + I
Sbjct: 367 IAEIGGAVTAVEAGELKRALVESNARRISAIEKGEQIVVGVNKWQQGEPSPLTAGDGAIF 426
Query: 485 KVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQE 544
V ++ + R+++ RS+RD + V +AL L AA + N+MP I A + T E
Sbjct: 427 TVSETVEMEAETRIREWRSKRDERAVGQALADLEQAA-RSGANIMPPSIAAAKAGVTTGE 485
Query: 545 VTDVLREIWGEYRAP 559
LRE++GEYRAP
Sbjct: 486 WGQRLREVFGEYRAP 500
>dbj|BAB07515.1| (AP001520) unknown [Bacillus halodurans]
Length = 1087
Score = 312 bits (792), Expect = 5e-84
Identities = 211/553 (38%), Positives = 312/553 (56%), Gaps = 46/553 (8%)
Query: 42 GFEIKRIYTP--ADLGE--NWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATA 97
G +I ++ P AD GE W LE + PG +PFT GV+ +G RQ+AG T
Sbjct: 541 GLKIPKVVLPKFADWGEILRWSMLENV--PGSFPFTAGVFPFKRKGED-PKRQFAGEGTP 597
Query: 98 EESNKRYKYLLSQGQTG-LSVAFDLPTQLGYDSDH-PLAEGEVGKVGVAIDSLWDMRILF 155
E +N+R+ YL + LS AFD T G D D+ P G+VG+ GV+I +L DM+ L+
Sbjct: 598 ERTNRRFHYLSKDDEAKRLSTAFDSVTLYGEDPDYRPDIYGKVGESGVSICTLDDMKKLY 657
Query: 156 DGIPLDKVSTS--MTINATAANLLAMYILVA----------EEQGVPQEK---------- 193
G L STS MTIN A +LAM++ A E VP E+
Sbjct: 658 AGFDLCAPSTSVSMTINGPAPIILAMFLNTAIDQQVEAFQRENDRVPSEEELADIKARTL 717
Query: 194 --LRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAEN-VPKWNPISISGYHIREA 250
+RGTVQ DILKE + T IF + ++R+ DI Y ++ V + +SISGYHI EA
Sbjct: 718 ATVRGTVQADILKEDQGQNTCIFSTEFALRMMGDIQQYFIDHHVRNYYSVSISGYHIAEA 777
Query: 251 GANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKF-RAARRL 309
GAN + ++AFTLA+G YV+ + RGMD++ FAP LSFFF+ N E R ARR+
Sbjct: 778 GANPISQLAFTLANGFTYVEYYLSRGMDINDFAPNLSFFFS--NGLDPEYTVIGRVARRI 835
Query: 310 WAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTN 369
W+ +MK + A N RS L++H QT+G +L AQ+ + N IR +QAL A+ SLHTN
Sbjct: 836 WSTVMKHKYGA-NERSQKLKYHIQTSGRSLHAQEIDFNDIRTTLQALMAIYDHCNSLHTN 894
Query: 370 SYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEK 429
+YDEA++ PTE+SVR A+ Q II E G+ + L G++ IE LT+ + E L +E+
Sbjct: 895 AYDEAITTPTEQSVRRAMAIQMIITKELGLAKNENSLQGSFIIEELTELVEEAVLAELEQ 954
Query: 430 IQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVT-----DEPIEVEIL 484
I GG++ A+E Y + +I E + Y+ + G+ I+GVN ++ +E ++E+
Sbjct: 955 INDRGGVLGAMETQYQRSKIQEESMHYEMKKHSGELPIIGVNTYMNPNEQDEEAFDLELA 1014
Query: 485 KVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEKEDENLMPYIIEAHRHLATLQE 544
+ +++QI LK + ER + EAL L+ A D N+ ++E + +A+L +
Sbjct: 1015 RATKEEKEQQIANLKAFQ-ERHKEIAPEALKALQETA-VNDGNIFAELMETVK-VASLGQ 1071
Query: 545 VTDVLREIWGEYR 557
+T L ++ G+YR
Sbjct: 1072 ITRALYQVGGQYR 1084
>gb|AAD53916.1|AF178673_2 (AF178673) MeaA [Streptomyces cinnamonensis]
Length = 167
Score = 215 bits (541), Expect = 1e-54
Identities = 103/161 (63%), Positives = 129/161 (79%)
Query: 82 RGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKV 141
+ R W MR YAG++TAE SN+ Y+ L++GQTGLSVAFDLPTQ GYD DH LA GEVG+V
Sbjct: 6 KDRPWLMRTYAGHSTAEASNELYRRNLAKGQTGLSVAFDLPTQTGYDPDHILARGEVGRV 65
Query: 142 GVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQND 201
GV + L DMR LF IPL++++TSMTINATA LLA+Y +VAEEQG KL+GT QND
Sbjct: 66 GVPVSHLGDMRRLFQDIPLEQMNTSMTINATAMWLLALYQVVAEEQGADITKLQGTTQND 125
Query: 202 ILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISI 242
I+KEY++RGT++FPP PS+RLTTD+I Y ++PKWNPI+I
Sbjct: 126 IVKEYLSRGTHVFPPGPSLRLTTDMITYTVAHIPKWNPINI 166
>dbj|BAB06675.1| (AP001517) methylmalonyl-CoA mutase beta subunit [Bacillus
halodurans]
Length = 681
Score = 181 bits (455), Expect = 2e-44
Identities = 122/432 (28%), Positives = 207/432 (47%), Gaps = 16/432 (3%)
Query: 74 RGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPL 133
R V+ + W + Q T E N+ K L++GQT L + D + G
Sbjct: 65 RHVHPVKRKNGKWLVSQELTQGTPESFNRTAKNDLARGQTALHMVIDQTVRDGLSPADQ- 123
Query: 134 AEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMYILVAEEQGVPQEK 193
+GE G+ G+ + + DM +GI + V + A LA + +A
Sbjct: 124 -KGETGRTGLLLYNHEDMETALEGIDVSSVPIHLNGGAVQTPFLASLLAIAPTS------ 176
Query: 194 LRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGAN 253
L G V D + E++ +G+ + + + + E I + + GA
Sbjct: 177 LHGVVGADPIHEWVKKGSLSYSWRTVFDELSHSVQVVNERALDLKTILVQSHVYHNGGAT 236
Query: 254 AVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYI 313
A +E+AF LA G++YV+A++ER + +D + ++ +EIAK RA R LWA I
Sbjct: 237 ATEELAFLLATGVQYVRALLERDIAIDDIGRSFCMSVSVGSDLFKEIAKLRALRLLWANI 296
Query: 314 MKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDE 373
M+ + K R++ L H +T+ T T P N++R +A AA +GG SLH + +DE
Sbjct: 297 MEAFGAEKEGRNIWL--HARTSFYTKTVYDPYVNMLRGTGEAFAAAVGGADSLHVSPFDE 354
Query: 374 ALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKM 433
+ P+ S RIA T I+ E+ + DP G++Y+E LT+ + E A + I+
Sbjct: 355 PIQKPSPFSRRIARNTSIILQEEAHIGQVEDPAAGSWYVEVLTEKLGEAAWSLFQTIESE 414
Query: 434 GGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKFVT--DEPI----EVEILKVD 487
GGM+ ++E+G Q+ + + + ++ E K ++VG N++V ++P+ E I
Sbjct: 415 GGMIASLEKGLPQQWVERSRQRQEQAAEVRKTVMVGTNRYVAIDEKPLTKQEEEPIAPYR 474
Query: 488 PSIRDKQIERLK 499
+IR KQ + LK
Sbjct: 475 EAIRTKQEKHLK 486
>sp|Q05064|MUTA_STRCM METHYLMALONYL-COA MUTASE SMALL SUBUNIT (MCM-BETA)
>gi|538978|pir||A40595 methylmalonyl-CoA mutase (EC
5.4.99.2) mutA chain - Streptomyces cinnamonensis
>gi|153366|gb|AAA03040.1| (L10064) methylmalonyl-CoA
small subunit [Streptomyces cinnamonensis]
Length = 616
Score = 177 bits (444), Expect = 3e-43
Identities = 132/472 (27%), Positives = 213/472 (44%), Gaps = 40/472 (8%)
Query: 40 DDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEE 99
+DG + +YT D + GFPG PF RG W +RQ A
Sbjct: 52 EDGLTTRPLYTARDAAPD------AGFPGFAPFVRGSVPEGNTPGGWDVRQRYASADPAR 105
Query: 100 SNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIP 159
+N+ L G T L + +G G+ + L DG+
Sbjct: 106 TNEAVLTDLENGVTSLWLT-------------------LGSAGLPVTGL---ERALDGVY 143
Query: 160 LDKVSTSMTINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPS 219
LD V ++ + AA + + E GV + +RGT+ D L G S
Sbjct: 144 LDLVPVALDAGSEAATAARELLRLYEAAGVADDAVRGTLGADPLGHEARTGE----KSTS 199
Query: 220 MRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDV 279
++ C E P +++ EAGA+A QE+ +LA G+EY++A+ ++G+ V
Sbjct: 200 FAAVAELARLCGERYPGLRALTVDALPYHEAGASAAQELGASLATGVEYLRALHDKGLGV 259
Query: 280 DKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTL 339
+K +L F FAA + IAK RAARRLWA + + + P + R H T+ +
Sbjct: 260 EKAFAQLEFRFAATADQFLTIAKLRAARRLWARVAEV---SGVPAAGAQRQHAVTSPVMM 316
Query: 340 TAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGV 399
T + P N++R + L A +GG ++ +D L LP + RIA T I+ ES +
Sbjct: 317 TRRDPWVNMLRTTVACLGAGVGGADAVTVLPFDHELGLPDAFARRIARNTSTILLEESHL 376
Query: 400 VDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKE 459
+DP GG++Y+E LTD + A + ++I++ G + A+ G V IA + +K+
Sbjct: 377 ARVIDPAGGSWYVERLTDELAHAAWDFFKEIERADGQVAALRSGLVGDRIAATWAERRKK 436
Query: 460 IEEGKRIIVGVNKF--VTDEPIEVEILKVDPS---IRDKQIERLKKLRSERD 506
+ + I GV++F +T+ P+E E P R ++ E ++LR D
Sbjct: 437 LARRREPITGVSEFPLLTERPVEREPAPAAPPGGLPRVRRDEAYEELRGRSD 488
>pdb|1E1C|B Chain B, Methylmalonyl-Coa Mutase H244a Mutant
>gi|8569650|pdb|1E1C|D Chain D, Methylmalonyl-Coa Mutase
H244a Mutant >gi|3660442|pdb|6REQ|B Chain B,
Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Coa Inhibitor
Complex >gi|3660444|pdb|6REQ|D Chain D,
Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Coa Inhibitor
Complex >gi|4389056|pdb|4REQ|B Chain B,
Methylmalonyl-Coa Mutase Substrate Complex
>gi|4389058|pdb|4REQ|D Chain D, Methylmalonyl-Coa Mutase
Substrate Complex >gi|7546642|pdb|5REQ|B Chain B,
Methylmalonyl-Coa Mutase, Y89f Mutant, Substrate Complex
>gi|7546644|pdb|5REQ|D Chain D, Methylmalonyl-Coa
Mutase, Y89f Mutant, Substrate Complex
>gi|3660450|pdb|7REQ|B Chain B, Methylmalonyl-Coa
Mutase, 2-Carboxypropyl-Coa Inhibitor Complex
>gi|3660452|pdb|7REQ|D Chain D, Methylmalonyl-Coa
Mutase, 2-Carboxypropyl-Coa Inhibitor Complex
>gi|1942489|pdb|1REQ|B Chain B, Methylmalonyl-Coa Mutase
>gi|1942491|pdb|1REQ|D Chain D, Methylmalonyl-Coa Mutase
>gi|2981907|pdb|3REQ|B Chain B, Methylmalonyl-Coa
Mutase, Substrate-Free State (Poor Quality Structure)
>gi|2914200|pdb|2REQ|B Chain B, Methylmalonyl-Coa
Mutase, Non-Productive Coa Complex, In Open Conformation
Representing Substrate-Free State >gi|2914202|pdb|2REQ|D
Chain D, Methylmalonyl-Coa Mutase, Non-Productive Coa
Complex, In Open Conformation Representing
Substrate-Free State
Length = 637
Score = 148 bits (370), Expect = 1e-34
Identities = 141/527 (26%), Positives = 235/527 (43%), Gaps = 60/527 (11%)
Query: 12 KEEEKRWEETTVKKFLEKA--PERKEKFM---------TDDGFEIKRIYTPADLGENWDY 60
K E++WE V+K L + PE++ F T DG +I +Y P D +
Sbjct: 28 KATEEQWERE-VEKVLNRGRPPEKQLTFAECLKRLTVHTVDGIDIVPMYRPKDAPK---- 82
Query: 61 LEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD 120
KLG+PG PFTRG W +R + + K L +G T L + D
Sbjct: 83 --KLGYPGVAPFTRGTTVRNGDMDAWDVRALHEDPDEKFTRKAILEGLERGVTSLLLRVD 140
Query: 121 LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMY 180
D L++ + V + S +D A A L+++Y
Sbjct: 141 PDAIAPEHLDEVLSDVLLEMTKVEVFSRYDQ------------------GAAAEALVSVY 182
Query: 181 ILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI 240
E P + L + D + +GT +P + + D + A+ P +
Sbjct: 183 ----ERSDKPAKDLALNLGLDPIGFAALQGT-----EPDLTVLGDWVRRLAKFSPDSRAV 233
Query: 241 SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSF-FFAAHNNFLEE 299
+I AGA V E+A+ LA G EYV+A++E+G + ++F A H+ FL
Sbjct: 234 TIDANIYHNAGAGDVAELAWALATGAEYVRALVEQGFTATEAFDTINFRVTATHDQFLT- 292
Query: 300 IAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAV 359
IA+ RA R WA I + + ++ R R + T+ LT + P NI+R +I +A
Sbjct: 293 IARLRALREAWARIGEVFGVDEDKRGA--RQNAITSWRELTREDPYVNILRGSIATFSAS 350
Query: 360 LGGTQSLHTNSYDEALSLPTEK-SVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDH 418
+GG +S+ T + +AL LP + +RIA T ++A E + DP GG+YY+E LT
Sbjct: 351 VGGAESITTLPFTQALGLPEDDFPLRIARNTGIVLAEEVNIGRVNDPAGGSYYVESLTRS 410
Query: 419 IFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKF--VTD 476
+ + A K ++++K+GGM +A+ +V K + + K + K+ I V++F +
Sbjct: 411 LADAAWKEFQEVEKLGGMSKAVMTEHVTKVLDACNAERAKRLANRKQPITAVSEFPMIGA 470
Query: 477 EPIEVEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEK 523
IE + P+ K L RD++ E+ +D+ + +E+
Sbjct: 471 RSIETKPFPAAPA--------RKGLAWHRDSEVFEQLMDRSTSVSER 509
>sp|P11652|MUTA_PROFR METHYLMALONYL-COA MUTASE SMALL SUBUNIT (MCB-BETA)
>gi|80622|pir||S04640 methylmalonyl-CoA mutase (EC
5.4.99.2) beta chain - Propionibacterium freudenreichii
subsp. shermanii >gi|45834|emb|CAA33089.1| (X14965) mutA
product, methylmalonyl-CoA mutase beta-subunit (AA
1-638) [Propionibacterium freudenreichii subsp.
shermanii]
Length = 638
Score = 147 bits (368), Expect = 3e-34
Identities = 140/527 (26%), Positives = 235/527 (44%), Gaps = 60/527 (11%)
Query: 12 KEEEKRWEETTVKKFLEKA--PERKEKFM---------TDDGFEIKRIYTPADLGENWDY 60
K E++WE V+K L + PE++ F T DG +I +Y P D +
Sbjct: 29 KATEEQWERE-VEKVLNRGRPPEKQLTFAECLKRLTVHTVDGIDIVPMYRPKDAPK---- 83
Query: 61 LEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD 120
KLG+PG PFTRG W +R + + K L +G T L + D
Sbjct: 84 --KLGYPGVAPFTRGTTVRNGDMDAWDVRALHEDPDEKFTRKAILEGLERGVTSLLLRVD 141
Query: 121 LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSMTINATAANLLAMY 180
D L++ + V + S +D A A L+++Y
Sbjct: 142 PDAIAPEHLDEVLSDVLLEMTKVEVFSRYDQ------------------GAAAEALVSVY 183
Query: 181 ILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI 240
E P + L + D + +GT +P + + D + A+ P +
Sbjct: 184 ----ERSDKPAKDLALNLGLDPIAFAALQGT-----EPDLTVLGDWVRRLAKFSPDSRAV 234
Query: 241 SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSF-FFAAHNNFLEE 299
+I AGA V E+A+ LA G EYV+A++E+G + ++F A H+ FL
Sbjct: 235 TIDANIYHNAGAGDVAELAWALATGAEYVRALVEQGFTATEAFDTINFRVTATHDQFLT- 293
Query: 300 IAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIIRVAIQALAAV 359
IA+ RA R WA I + + ++ R R + T+ +T + P NI+R +I +A
Sbjct: 294 IARLRALREAWARIGEVFGVDEDKRGA--RQNAITSWRDVTREDPYVNILRGSIATFSAS 351
Query: 360 LGGTQSLHTNSYDEALSLPTEK-SVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDH 418
+GG +S+ T + +AL LP + +RIA T ++A E + DP GG+YY+E LT
Sbjct: 352 VGGAESITTLPFTQALGLPEDDFPLRIARNTGIVLAEEVNIGRVNDPAGGSYYVESLTRS 411
Query: 419 IFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEEGKRIIVGVNKF--VTD 476
+ + A K ++++K+GGM +A+ +V K + + K + K+ I V++F +
Sbjct: 412 LADAAWKEFQEVEKLGGMSKAVMTEHVTKVLDACNAERAKRLANRKQPITAVSEFPMIGA 471
Query: 477 EPIEVEILKVDPSIRDKQIERLKKLRSERDNKKVEEALDKLRNAAEK 523
IE + P+ K L RD++ E+ +D+ + +E+
Sbjct: 472 RSIETKPFPAAPA--------RKGLAWHRDSEVFEQLMDRSTSVSER 510
>sp|Q59676|MUTB_PORGI METHYLMALONYL-COA MUTASE ALPHA-SUBUNIT (MCM-ALPHA)
>gi|2126436|pir||JC4559 methylmalonyl-CoA mutase (EC
5.4.99.2) small chain - Porphyromonas gingivalis
>gi|463174|gb|AAB51083.1| (L30136) methylmalonyl-CoA
mutase alpha-subunit [Porphyromonas gingivalis]
>gi|1586534|prf||2204234A methylmalonyl-CoA
mutase:SUBUNIT=small [Porphyromonas gingivalis]
Length = 617
Score = 144 bits (360), Expect = 2e-33
Identities = 117/444 (26%), Positives = 192/444 (42%), Gaps = 36/444 (8%)
Query: 32 ERKEKFMTDDGFEIKRIYTPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQY 91
E+K + T++GF + Y D+ D P EYP+ R M+ W +RQ
Sbjct: 34 EKKLVWRTNEGFNVNPFYRREDIE---DLKTTTSLPDEYPYVRST--RMHNE--WLVRQD 86
Query: 92 AGYA-TAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWD 150
E+N++ LL++G L KV + +D+L
Sbjct: 87 IVVGDNVAEANEKALDLLNKGVDSLGFYLK-------------------KVHINVDTL-- 125
Query: 151 MRILFDGIPLDKVSTSMTINAT-AANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIAR 209
L I L V + T AA+LL+ + ++ G K G+V D K+ + R
Sbjct: 126 -AALLKDIELTAVELNFNCCITRAADLLSAFSAYVKKVGADPNKCHGSVSYDPFKKQLVR 184
Query: 210 GTYIFPPQPSMRLTTDIIMYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYV 269
G P T +M A +P + ++++ ++ +AGA QE+ + LA G E +
Sbjct: 185 GV----SNPDWVKMTLPVMDAARELPAFRVLNVNAVNLSDAGAFITQELGYALAWGAELL 240
Query: 270 KAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLR 329
+ + G ++ A R+ F F +N+ EIAKFRAAR LWA I+ + + + +
Sbjct: 241 DKLTDAGYKPEEIASRIKFNFGIGSNYFMEIAKFRAARWLWAQIVGSYGDQYKNETAKIH 300
Query: 330 FHTQTAGSTLTAQQPENNIIRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRT 389
H T+ T N++R + ++A + G S+ +D + S RIA
Sbjct: 301 QHATTSMWNKTVFDAHVNLLRTQTETMSAAIRGVDSITVLPFDVTYQQSDDFSERIARNQ 360
Query: 390 QQIIAYESGVVDTVDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEI 449
Q ++ E +DP G+YYIE LT+ I EEA K ++ GG +A E +QK +
Sbjct: 361 QLLLKEECHFDKVIDPSAGSYYIETLTNSIGEEAWKLFLSVEDAGGFTQAAETASIQKAV 420
Query: 450 AEAAYKYQKEIEEGKRIIVGVNKF 473
+ K + I +G N+F
Sbjct: 421 NASNIKRPVGATR-REIFLGTNQF 443
>sp|P71773|MUTA_MYCTU PROBABLE METHYLMALONYL-COA MUTASE SMALL SUBUNIT (MCM)
>gi|7449060|pir||G70711 probable mutA protein -
Mycobacterium tuberculosis (strain H37RV)
>gi|1524239|emb|CAB02042.1| (Z79701) mutA [Mycobacterium
tuberculosis]
Length = 615
Score = 118 bits (294), Expect = 1e-25
Identities = 121/491 (24%), Positives = 206/491 (41%), Gaps = 58/491 (11%)
Query: 1 MTFDVEKLKKIKEEEKRWEETTVKKFLEKA-----------PERKEKFMTDDGFEIKRIY 49
M+ DV + +++ RW V L K+ PER T DGF I+ +Y
Sbjct: 1 MSIDVPERADLEQVRGRWRNA-VAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALY 59
Query: 50 TPADLGENWDYLEKLGFPGEYPFTRGVYATMYRGRIWTMRQY--AGYATAEESNKRYKYL 107
T +D L + PG++PF RG W + + A ATA+ +N
Sbjct: 60 TA------FDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATAD-TNAAVLAA 112
Query: 108 LSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMRILFDGIPLDKVSTSM 167
L +G + L + VG+ GVA D L L G+ L+ +
Sbjct: 113 LGEGVSALLI-------------------RVGESGVAPDRL---TALLSGVYLNLAPVIL 150
Query: 168 TINATAANLLAMYILVAEEQGVPQEKLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDII 227
A + + + + Q R T+ D+ + + P P +
Sbjct: 151 DAGADYRPACDVMLALVAQLDPGQ---RDTLSIDLGADPLTASLRDRPAPPIEEVVAVAS 207
Query: 228 MYCAENVPKWNPISISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLS 287
E + I++ G GA A E+A T+A + Y++ + E G+ V ++S
Sbjct: 208 RAAGERGLR--AITVDGPAFHNLGATAATELAATVAAAVAYLRVLTESGLVVSDALRQIS 265
Query: 288 FFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENN 347
F AA ++ +AK RA R+LWA + + +P H +T+ +T + P N
Sbjct: 266 FRLAADDDQFMTLAKMRALRQLWARVAEV---VGDPGGGAAVVHAETSLPMMTQRDPWVN 322
Query: 348 IIRVAIQALAAVLGGTQSLHTNSYDEAL-----SLPTEKSVRIALRTQQIIAYESGVVDT 402
++R + A A +GG ++ + +D A+ + RIA TQ ++ ES V
Sbjct: 323 MLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRV 382
Query: 403 VDPLGGAYYIEWLTDHIFEEALKYIEKIQKMGGMMRAIERGYVQKEIAEAAYKYQKEIEE 462
+DP GG++++E LTD + A + + I+ GG + A ++ +IAE A + +I
Sbjct: 383 LDPAGGSWFVEELTDRLARRAWQRFQAIEARGGFVEA--HDFLAGQIAECAARRADDIAH 440
Query: 463 GKRIIVGVNKF 473
+ I GVN++
Sbjct: 441 RRLAITGVNEY 451
>gb|AAB31158.1| methylmalonyl CoA mutase, MCM {EC 5.4.99.2} [human, mut-
methylmalonic acidemia patient, Peptide Partial Mutant,
274 aa]
Length = 274
Score = 77.3 bits (187), Expect = 4e-13
Identities = 38/100 (38%), Positives = 62/100 (62%), Gaps = 1/100 (1%)
Query: 460 IEEGKRIIVGVNKFVTDEPIEVEILKVD-PSIRDKQIERLKKLRSERDNKKVEEALDKLR 518
I+ G +IVGVNK+ ++ VE+L D S+R++QI +LKK++S RD E L L
Sbjct: 3 IDSGSEVIVGVNKYQLEKEDAVEVLATDNTSVRNRQIGKLKKIKSSRDQALAEHCLAALT 62
Query: 519 NAAEKEDENLMPYIIEAHRHLATLQEVTDVLREIWGEYRA 558
A D N++ ++A R T+ E+TD L++++GE++A
Sbjct: 63 ECAASGDGNILALAVDASRARCTVGEITDALKKVFGEHKA 102
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.136 0.391
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 206148087
Number of Sequences: 2977
Number of extensions: 8770051
Number of successful extensions: 31945
Number of sequences better than 1.0e-10: 45
Number of HSP's better than 0.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 31796
Number of HSP's gapped (non-prelim): 51
length of query: 562
length of database: 189,106,746
effective HSP length: 59
effective length of query: 503
effective length of database: 153,796,013
effective search space: 77359394539
effective search space used: 77359394539
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 167 (69.5 bits)