BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1850 (PAB1850) DE:sodium- and chloride-dependent transporter
(527 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||A75122 sodium- and chloride-dependent transporter PAB1850 -... 1074 0.0
pir||F71009 probable sodium-dependent transporter - Pyrococcus h... 1009 0.0
pir||B70478 probable sodium symporter snf [similarity] - Aquifex... 333 2e-90
sp|Q58715|YD19_METJA HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER M... 190 4e-47
gi|11499577 sodium- and chloride-dependent transporter [Archaeog... 188 1e-46
gb|AAG19815.1| (AE005066) daunorubicin resistance ABC transporte... 178 1e-43
pir||E82127 sodium-dependent transporter VC2012 [imported] - Vib... 177 2e-43
sp|P44849|Y736_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER H... 176 4e-43
dbj|BAB04847.1| (AP001511) sodium-dependent transporter [Bacillu... 169 5e-41
pir||G82096 sodium-dependent transporter VC2283 [imported] - Vib... 166 8e-40
pir||B82171 probable sodium-dependent transporter VC1669 [import... 161 2e-38
pir||E81964 probable sodium-dependent inner membrane transport p... 156 7e-37
pir||H81019 sodium- and chloride-dependent transporter NMB1975 [... 156 7e-37
pir||F81050 sodium- and chloride-dependent transporter NMB1707 [... 155 1e-36
pir||G81824 probable integral membrane ion transporter NMA1961 [... 154 2e-36
gb|AAG19816.1| (AE005066) sodium- and chloride-dependent transpo... 152 8e-36
pir||T46663 probable sodium/chloride ion channel [imported] - Ne... 152 1e-35
pir||D69902 sodium-dependent transporter homolog yocR - Bacillus... 150 3e-35
pir||F69825 sodium-dependent transporter homolog yhdH - Bacillus... 150 4e-35
dbj|BAB03936.1| (AP001507) sodium-dependent transporter [Bacillu... 148 1e-34
dbj|BAB07158.1| (AP001518) sodium-dependent transporter [Bacillu... 148 1e-34
pir||F81367 probable transmembrane transport protein Cj0935c [im... 145 2e-33
pir||G71930 probable transporter - Helicobacter pylori (strain J... 140 4e-32
sp|P45320|YG90_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER H... 140 4e-32
pir||B64582 sodium- and chloride-dependent transporter - Helicob... 138 1e-31
pir||E81367 probable transmembrane transport protein Cj0934c [im... 136 5e-31
dbj|BAA24689.1| (AB010832) putative tryptophan tranporter; simil... 131 3e-29
pir||H81407 probable sodium-dependent transmembrane transport pr... 130 4e-29
gb|AAF73566.1| (AE002319) sodium-dependent transporter, putative... 123 6e-27
gb|AAC46377.1| (AF017105) sodium-dependent transporter [Chlamydo... 121 2e-26
pir||C71541 probable na-dependent transporter - Chlamydia tracho... 121 2e-26
pir||F72095 na-dependent transporter - Chlamydophila pneumoniae ... 120 4e-26
gb|AAF73672.1| (AE002208) sodium-dependent transporter, putative... 120 4e-26
dbj|BAA89537.1| (AB006986) taurine transporter [Cyprinus carpio] 119 9e-26
pir||A64582 sodium- and chloride-dependent transporter - Helicob... 117 4e-25
dbj|BAB18038.1| (AB033497) taurine transporter [Tilapia mossambica] 114 3e-24
gi|6678223 taurine/beta-alanine transporter [Mus musculus] >gi|6... 114 3e-24
pir||F71930 probable transporter - Helicobacter pylori (strain J... 114 3e-24
gi|8394318 taurine/beta-alanine transporter [Rattus norvegicus] ... 113 4e-24
sp|O35316|NTTA_MOUSE SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND ... 113 7e-24
gb|AAF76147.1|AF260239_1 (AF260239) taurine transporter [Bos tau... 111 2e-23
gb|AAF57986.1| (AE003806) DAT gene product [Drosophila melanogas... 111 2e-23
pir||S46487 taurine transporter - human >gi|559853|gb|AAA50842.1... 110 3e-23
gi|11433499 solute carrier family 6 (neurotransmitter transporte... 110 3e-23
sp|P31641|NTTA_HUMAN SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRAN... 110 3e-23
gi|4507045 solute carrier family 6 (neurotransmitter transporter... 110 5e-23
sp|P31652|NTSE_RAT SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT T... 109 6e-23
pir||S19585 serotonin transport protein - rat >gi|228225|prf||17... 109 6e-23
pir||A47194 taurine and beta-alanine transporter, TAUT - mouse 109 8e-23
sp|P31642|NTTA_MUSCO SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND ... 109 8e-23
sp|Q00589|NTTA_CANFA SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRAN... 109 1e-22
pir||A46270 Na and Cl dependent taurine transporter - dog 109 1e-22
sp|Q60857|NTSE_MOUSE SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT... 108 1e-22
gb|AAD26262.1|AF119122_1 (AF119122) serotonin transporter [Bos t... 108 1e-22
gi|8394200 GABA transporter [Rattus norvegicus] >gi|881598|gb|AA... 108 2e-22
sp|P48056|NTBE_RAT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSP... 108 2e-22
gi|7110639 5-hydroxytryptamine (serotonin) transporter [Mus musc... 107 3e-22
pir||S63539 GABA/beta-alanine transporter - marbled electric ray... 106 9e-22
sp|P31651|NTBE_MOUSE SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRAN... 105 2e-21
gi|6981554 solute carrier family 6 (neurotransmitter transporter... 105 2e-21
gb|AAC05185.1| (AF049108) GABA transporter [Raja sp.] 104 2e-21
gb|AAF97247.1|AF285761_1 (AF285761) serotonin transporter [Macac... 104 2e-21
gi|4507039 solute carrier family 6 (neurotransmitter transporter... 104 3e-21
sp|O35899|NTSE_CAVPO SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT... 104 3e-21
sp|P23978|NTG1_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORT... 104 3e-21
sp|P48057|NTG1_MUSCO SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO... 103 4e-21
pir||S65673 GABA transport protein - tobacco hornworm >gi|695378... 103 6e-21
pir||S68236 betaine/GABA transport protein BGT-1 - human >gi|881... 102 8e-21
gi|4507037 solute carrier family 6 (neurotransmitter transporter... 102 8e-21
gb|AAG01287.1|AF246893_1 (AF246893) serotonin transporter [Ovis ... 101 2e-20
sp|P31646|NTG2_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORT... 101 3e-20
sp|P48055|NTBE_RABIT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRAN... 101 3e-20
sp|P31648|NTG1_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO... 100 4e-20
pir||I51368 gamma-aminobutyric acid transport protein GAT-1 - Pa... 99 9e-20
gb|AAG20907.1| (AE005157) sodium-dependent transporter; YocR [Ha... 99 9e-20
gi|4507043 solute carrier family 6 (neurotransmitter transporter... 99 1e-19
gi|7657587 solute carrier family 6 (neurotransmitter transporter... 99 1e-19
gi|11428196 solute carrier family 6 (neurotransmitter transporte... 99 1e-19
sp|P27799|NTBE_CANFA SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRAN... 98 3e-19
gb|AAF21642.1|AF032873_1 (AF032873) inebriated protein [Manduca ... 98 3e-19
sp|P31649|NTG3_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO... 97 4e-19
pir||I56506 Na+/Cl(-)-dependent neurotransmitter transporter, br... 96 8e-19
sp|P31662|NTT4_RAT SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER NT... 96 1e-18
pir||C71376 probable sodium- and chloride- dependent transporter... 95 2e-18
gb|AAD10615.1| (U02296) cocaine-sensitive serotonin transporter ... 94 4e-18
sp|P51905|NTSE_DROME SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT... 94 4e-18
pir||JH0674 L-proline transport protein - rat 93 9e-18
sp|P28573|NTPR_RAT SODIUM-DEPENDENT PROLINE TRANSPORTER >gi|2052... 93 9e-18
sp|P31647|NTG3_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORT... 93 9e-18
sp|P31650|NTG4_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO... 90 4e-17
gi|7657589 solute carrier family 6 (neurotransmitter transporter... 90 4e-17
gi|11416778 solute carrier family 6 (neurotransmitter transporte... 90 4e-17
gi|11434830 solute carrier family 6 (neurotransmitter transporte... 90 6e-17
gb|AAF45873.2| (AE003427) CG10804 gene product [Drosophila melan... 89 1e-16
gb|AAC47292.1| (U66460) inebriated [Drosophila melanogaster] 89 1e-16
emb|CAA69649.1| (Y08362) neurotransmitter transporter [Drosophil... 89 1e-16
gb|AAF51001.1| (AE003576) ine gene product [Drosophila melanogas... 89 1e-16
gi|8394204 X transporter protein 2 [Rattus norvegicus] >gi|53146... 89 1e-16
gb|AAF98299.1|AF237673_1 (AF237673) norepinephrine transporter [... 89 2e-16
gb|AAC27757.1| (AF075262) orphan transporter isoform A12 [Mus mu... 88 3e-16
gb|AAC27758.1| (AF075263) orphan transporter isoform A11 [Mus mu... 88 3e-16
gb|AAC27759.1| (AF075264) orphan transporter isoform B11 [Mus mu... 88 3e-16
gb|AAC27760.1| (AF075265) orphan transporter isoform A10 [Mus mu... 88 3e-16
gb|AAC27761.1| (AF075266) orphan transporter isoform B9 [Mus mus... 88 3e-16
gi|6756029 X transporter protein 2 [Mus musculus] >gi|3347932|gb... 88 3e-16
gb|AAF89166.1|AF230787_1 (AF230787) norepinephrine transporter [... 87 6e-16
pir||S46260 creatine transporter - marbled electric ray >gi|5417... 83 7e-15
pir||T20052 hypothetical protein C49C3.1 - Caenorhabditis elegan... 82 1e-14
gi|11436405 solute carrier family 6 (neurotransmitter transporte... 82 2e-14
gi|11436403 solute carrier family 6 (neurotransmitter transporte... 82 2e-14
emb|CAB60372.1| (AL110485) contains similarity to Pfam domain: P... 81 3e-14
gb|AAF70819.1|AF141930_1 (AF141930) high affinity GABA transport... 81 4e-14
gi|7705539 solute carrier family 6 (neurotransmitter transporter... 79 1e-13
emb|CAB42788.1| (AL034411) dJ808P6.1 (novel Sodium:neurotransmit... 76 1e-12
gb|AAF59549.1| (AC024812) contains similarity to SW:NTSE_DROME [... 75 3e-12
gi|11181770 X transporter protein 3 [Homo sapiens] >gi|8980368|e... 73 8e-12
gi|6756031 X transporter protein 3 [Mus musculus] >gi|3347920|gb... 71 3e-11
pir||S50998 transporter protein (clone rB21a) - rat >gi|914028|g... 70 7e-11
gb|AAC27755.1| (AF075260) orphan transporter [Homo sapiens] 69 9e-11
>pir||A75122 sodium- and chloride-dependent transporter PAB1850 - Pyrococcus
abyssi (strain Orsay) >gi|5458201|emb|CAB49690.1|
(AJ248285) sodium-and chloride-dependent transporter
[Pyrococcus abyssi]
Length = 527
Score = 1074 bits (2747), Expect = 0.0
Identities = 527/527 (100%), Positives = 527/527 (100%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL
Sbjct: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
Query: 61 GIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNS 120
GIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNS
Sbjct: 61 GIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNS 120
Query: 121 YYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGV 180
YYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGV
Sbjct: 121 YYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGV 180
Query: 181 SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW 240
SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW
Sbjct: 181 SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW 240
Query: 241 SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPL 300
SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPL
Sbjct: 241 SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPL 300
Query: 301 AVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLL 360
AVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLL
Sbjct: 301 AVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLL 360
Query: 361 WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS 420
WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS
Sbjct: 361 WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS 420
Query: 421 FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFT 480
FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFT
Sbjct: 421 FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFT 480
Query: 481 DLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL 527
DLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL
Sbjct: 481 DLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL 527
>pir||F71009 probable sodium-dependent transporter - Pyrococcus horikoshii
>gi|3257795|dbj|BAA30478.1| (AP000006) 521aa long
hypothetical sodium-dependent transporter [Pyrococcus
horikoshii]
Length = 521
Score = 1009 bits (2580), Expect = 0.0
Identities = 490/522 (93%), Positives = 506/522 (96%), Gaps = 1/522 (0%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
+ MEQR++WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM
Sbjct: 1 MDMEQRERWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 60
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSAL FGLIGGALAFATTTLLNSYYLHL
Sbjct: 61 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALWFGLIGGALAFATTTLLNSYYLHL 120
Query: 126 IGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIE 185
IGWSAAYSWFSI+GAY+ ++TA+FF YLSNHGLVFLFWGITVVLL IAVGQGVSKGIE
Sbjct: 121 IGWSAAYSWFSITGAYYG-KNTAQFFSQYLSNHGLVFLFWGITVVLLGIAVGQGVSKGIE 179
Query: 186 RWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLA 245
RWVKVMMPLLYVFA+ILVIYVFALGSPLGQPQWSTIKGFEFIWSPNW YLK+HLW VMLA
Sbjct: 180 RWVKVMMPLLYVFAIILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWGYLKDHLWKVMLA 239
Query: 246 ASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYA 305
ASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYA
Sbjct: 240 ASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYA 299
Query: 306 PKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGF 365
PKIVPP+VLAKGS+AAL WISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGF
Sbjct: 300 PKIVPPDVLAKGSDAALAWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGF 359
Query: 366 TSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLAL 425
TSAIAMYNYLTALLEEDLGI R GTW+VFIIYFLLGIPVVYINGYLDQVDAWISFQLAL
Sbjct: 360 TSAIAMYNYLTALLEEDLGIKRSVGTWVVFIIYFLLGIPVVYINGYLDQVDAWISFQLAL 419
Query: 426 LALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSK 485
LALFDIIV VWLFKPDNFW+ELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSK
Sbjct: 420 LALFDIIVSVWLFKPDNFWRELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSK 479
Query: 486 TLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL 527
TLGWPAKIAI+ ML IGAIEAYYAIKKKYGEELEKNEVIIK+
Sbjct: 480 TLGWPAKIAILTMLTIGAIEAYYAIKKKYGEELEKNEVIIKV 521
>pir||B70478 probable sodium symporter snf [similarity] - Aquifex aeolicus
>gi|2984293|gb|AAC07817.1| (AE000771)
Na(+):neurotransmitter symporter (Snf family) [Aquifex
aeolicus]
Length = 513
Score = 333 bits (846), Expect = 2e-90
Identities = 199/536 (37%), Positives = 296/536 (55%), Gaps = 57/536 (10%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ WAT++GLILAMAGNA+GLGNF+RFP Q A NGGGAFM+PY +A L+GIP+MW+EW
Sbjct: 4 KREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEW 63
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
GRYGG GHGT FYL+ R R A I G+ G + YY+++ W+
Sbjct: 64 AMGRYGGAQGHGTTPAIFYLLWRN----RFAKILGVFGLWIPLVVAI----YYVYIESWT 115
Query: 130 AAYSWFSISGAY-------FNVESTAKFFESYLSNH--------------GLVFLFWGIT 168
++ + G + +S + F+ +L ++ ++ + IT
Sbjct: 116 LGFAIKFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLIT 175
Query: 169 VVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIW 228
+ + + +G+SKGIER+ K+ MP L++ AV LVI VF L +P G + G F+W
Sbjct: 176 MFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNG----TAADGLNFLW 231
Query: 229 SPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFA 288
+P++ LK+ V +AA GQIFFTLSLG G I YASY+ D+ LSGL +LNE A
Sbjct: 232 TPDFEKLKDP--GVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKA 289
Query: 289 EVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA 348
EV+LGGSI++P AVA+ + G+ F LGF +LP IF Q
Sbjct: 290 EVILGGSISIPAAVAFFGVANAVAIAKAGA----------FNLGF--ITLPAIFSQT-AG 336
Query: 349 GRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGT-WIVFIIYFLLGIPVVY 407
G F G LWF LL+FAG TS+IA+ + A LE++L +SRK W I++F + V++
Sbjct: 337 GTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHL-VMF 395
Query: 408 INGYLDQVDAWI-SFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVII 466
+N LD++D W + + L ++I+ W+F D W+E++ G +I VP Y ++ I
Sbjct: 396 LNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYI 455
Query: 467 APIFIALPLFGTFTDLVSKTLG------WPAKIAIIAMLIIGAIEAYYAIKKKYGE 516
P F+A+ L + + K + W + II + + + A +++ E
Sbjct: 456 TPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE 511
>sp|Q58715|YD19_METJA HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER MJ1319
>gi|2129285|pir||F64464 sodium-dependent noradrenaline
transporter homolog - Methanococcus jannaschii
>gi|1591959|gb|AAB99329.1| (U67572) sodium-dependent
transporter [Methanococcus jannaschii]
Length = 492
Score = 190 bits (477), Expect = 4e-47
Identities = 142/512 (27%), Positives = 246/512 (47%), Gaps = 63/512 (12%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ W++ +G ILA G+AIGLGN RF V NGGGAF++PY +AL +GIP+M +E+
Sbjct: 5 ERESWSSNLGFILASVGSAIGLGNIWRFGYMVYTNGGGAFLIPYIVALLCVGIPLMILEF 64
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G Y K +A E L S G A + ++ SYY+ +I W
Sbjct: 65 AIGHYTKKSAP---------LALEKLHKGSEWT-----GWFAVISGFIITSYYVVIIAWC 110
Query: 130 AAYSWFSISGAYFNVESTAKFFESYLS-----------NHGLV---FLFWGITVVLLAIA 175
Y + Y + + A FF + L ++G++ WGI ++L+
Sbjct: 111 LYYLIILVIYGYPS-DPNAYFFHNILQISSGVEDIGGVSYGILVSTLAVWGIVALILS-- 167
Query: 176 VGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYL 235
G+ G+E+ K+M+P L ++LV+ L L +W F +++
Sbjct: 168 --AGIKNGLEKANKIMIPFLLFLIILLVLNALTLPGALTGIEWYLTPDFSALFN------ 219
Query: 236 KEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGS 295
++V L+A QIFF+LSLG GI+ YASYL K D+ ++ + LN + G +
Sbjct: 220 ----YNVWLSAFSQIFFSLSLGFGILIAYASYLPKKSDLTINAVTVSLLNCGFSFLAGFA 275
Query: 296 IAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGAL 355
+ L +P + + +SE G+G ++ + P + A R FG +
Sbjct: 276 VFGTLGYMSYTSGIPLD----------KAVSE--GIGLAFVTFPKALSLLPFASRLFGIV 323
Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING----Y 411
+FL L FAG +SA+++ + + + +SRK V ++ + I ++ G Y
Sbjct: 324 FFLALVFAGISSAVSIVEASVSAIIDKFSLSRKKALLAVLALFII--ISPIFTTGAGLYY 381
Query: 412 LDQVDAWIS-FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIF 470
LD +D + S + L + A+ +II+ +WLF D + +++ + I + ++K++ +++PI
Sbjct: 382 LDIIDHFASGYLLPIAAILEIIIAIWLFGGDKLREHVNKLSEIKLGVWWKYLAGVVSPII 441
Query: 471 IALPLFGTFTD-LVSKTLGWPAKIAIIAMLII 501
+ +F ++ L S G+ I LII
Sbjct: 442 LTAVVFLDASNVLTSGYGGYKTTYVIFGALII 473
>gi|11499577 sodium- and chloride-dependent transporter [Archaeoglobus fulgidus]
>gi|7441661|pir||B69499 sodium- and chloride-dependent
transporter homolog - Archaeoglobus fulgidus
>gi|2648543|gb|AAB89259.1| (AE000965) sodium- and
chloride-dependent transporter [Archaeoglobus fulgidus]
Length = 491
Score = 188 bits (473), Expect = 1e-46
Identities = 155/517 (29%), Positives = 258/517 (48%), Gaps = 60/517 (11%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ WAT+ G +LA G+AIGLGN RF V NGGGAF++PYF+ALF+ GI +M +E+
Sbjct: 4 ERENWATRAGFVLAAIGSAIGLGNIWRFGYLVYKNGGGAFLIPYFVALFVAGISLMILEF 63
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+G F A S++ F IG A ++ YY +IGW+
Sbjct: 64 ------------AIGHRFRGSAPASMRKLGGRGFEWIGW-WAVTGGLIITMYYTVVIGWA 110
Query: 130 AAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGI-TVVLLAIAV---------GQG 179
Y S++ A+ ++ FF + L + F G T VL+A + +G
Sbjct: 111 IVYFTKSLTLAW-GEDTGGYFFGTVLQLSDNPWDFGGFATEVLIATIIVWALNWLVDFRG 169
Query: 180 VSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHL 239
+ KGIE+ ++MPLL++ AVILVI L ++G E+ P+++ L +
Sbjct: 170 IRKGIEKANLLLMPLLWLLAVILVIRAVTLP--------GAMEGIEWYLKPDFSKLGD-- 219
Query: 240 WSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVP 299
+++ LAA GQIFFTLSLGMGI+ YASYL K D+A + N ++G ++
Sbjct: 220 YNIWLAAFGQIFFTLSLGMGIMIAYASYLPEKSDIANNAFIVSLANCAFSFLVGFAVFGT 279
Query: 300 LA-VAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFL 358
L +AYA + +V+A+ +G ++ P + F A++FL
Sbjct: 280 LGYMAYATQSDISDVVAQ-------------SVGLAFVVFPKALNMLPALKVFTAAVFFL 326
Query: 359 LLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING--YLDQVD 416
L AG +S+I++ +++ L + G+ R+ IV ++ FL I G +LD VD
Sbjct: 327 ALVVAGLSSSISLVEAVSSALMDKFGMERRKAVNIVVLVGFLGSIVYTTKAGLYWLDVVD 386
Query: 417 AWISFQ-LALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFY----KWITVIIAPIFI 471
+I++ L L+ L ++I WLF ++ + I V ++ K+ T +I + +
Sbjct: 387 HFINYYGLVLVGLLEVIAAAWLFDLTVLKNHINSVSEIKVGMWWDLAVKFATPLILAVLL 446
Query: 472 ALPLFGTFTDLVSKTLGWPAKIAI--IAMLIIGAIEA 506
L + G T+ G+P ++ + ++++++G I A
Sbjct: 447 ILDIRGNLTENYG---GYPTEVLLTGLSIIVLGMIVA 480
>gb|AAG19815.1| (AE005066) daunorubicin resistance ABC transporter ATP-binding
protein; Trp6 [Halobacterium sp. NRC-1]
Length = 447
Score = 178 bits (448), Expect = 1e-43
Identities = 142/476 (29%), Positives = 221/476 (45%), Gaps = 51/476 (10%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
M +R+ WA+++G ILA G+A+GLGN +FP + A GG AF+V Y +A LLG+P +
Sbjct: 1 MAERETWASRLGFILAAVGSAVGLGNIWQFPFKTATEGGAAFVVVYLVAALLLGLPAILG 60
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
E+V GR L A E+ + ++ GA+ T + SYY + G
Sbjct: 61 EFVIGRRAN------------LNAVEAFDRLDHPAWTIV-GAMGLLTGLWILSYYSVVGG 107
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
W Y S +GAYF + A +F S +S F G + A V G+ GIE+
Sbjct: 108 WVTRYLLGSATGAYF--AAPAAYFGS-VSMGWEAVAFHGAFMAATAGIVAFGIEDGIEKA 164
Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKG----FEFIWSPNWTYLKEHLWSVM 243
K+M+P + V V L +Y ST+ G +EF SP++ ++ +++ S++
Sbjct: 165 TKLMVPSILVMLVGLAVYA------------STLNGVGAAYEFYLSPDFGFIADNIGSIV 212
Query: 244 LAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVA 303
A Q FF+LSLGMG + YASYLG D + G V LN + +L G + +PL
Sbjct: 213 PYAVSQAFFSLSLGMGAMITYASYLGDDDSLFADGGLIVVLNT-SVGLLAGLVVIPLLFV 271
Query: 304 YAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFA 363
+ P+ A G G G + S+ F +G AGR G L+F ++ A
Sbjct: 272 QFGTV--PDAAAGG------------GAGALFISVAQAFATLGVAGRVLGVLFFGVVLVA 317
Query: 364 GFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAW-ISFQ 422
+SAI++ +TA + ++ G SR + + F LG + +LD D+
Sbjct: 318 ALSSAISLLEVVTAYVVDNYGYSRPATAFSFGGVLFALGTLSAWNTAWLDWFDSLAYGVL 377
Query: 423 LALLALFDIIVGVWLFKP---DNFWKELHEGALINVPEFYKWITVIIAPIFIALPL 475
L L L ++ W++ P D K G + T ++ +F+ L L
Sbjct: 378 LPLSVLLGVVFVGWVYGPAAVDEIKKGSGTGTTFATAWLWSVRTYVLIGVFVTLYL 433
>pir||E82127 sodium-dependent transporter VC2012 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9656556|gb|AAF95160.1|
(AE004276) sodium-dependent transporter [Vibrio
cholerae]
Length = 527
Score = 177 bits (445), Expect = 2e-43
Identities = 153/529 (28%), Positives = 253/529 (46%), Gaps = 68/529 (12%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R++W +++G +LA G+AIGLGN RFP NGGGAF +PY A+ GIP M +E+
Sbjct: 43 KREQWGSRVGFVLAAVGSAIGLGNIWRFPYMAYENGGGAFFIPYLFAMVTAGIPFMILEF 102
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+ H PT + G+ ++ YY+ +IGW+
Sbjct: 103 SMGQ-----KHRGSAPTTLAKIHSKFEWLGWFQVGI---------AAVIAVYYVAVIGWA 148
Query: 130 AAYSWFSISGAYFNVESTAKFFESYL-----SNHGLVFLFWGITVVLLA------IAVGQ 178
+Y S + ++ ++ A FF YL S L + W I +L A+
Sbjct: 149 ISYFGMSFTQSW-GSDTNAYFFSEYLKLGDNSPTNLGSIQWHIAFAMLIAWVITYAAIVG 207
Query: 179 GVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEH 238
GV KGIER K+MMP+L++ +IL+ + L L G +++ P+++
Sbjct: 208 GVKKGIERASKIMMPILFIMVLILIARMIFLPGAL--------DGVNYMFQPDFS----K 255
Query: 239 LWSVML--AASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSI 296
+W V + AA GQIFFTLS+G I+ Y+SYL K D+ + TV +N V+ G I
Sbjct: 256 IWDVKVWAAAYGQIFFTLSIGFAIMLAYSSYLPEKSDITNNAFMTVLINCGFSVLAG--I 313
Query: 297 AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALW 356
+ + Y +A+ L + + G+G ++ +LP + + G L+
Sbjct: 314 MIFSVLGY---------MAQEQGKPLTEV-VSAGVGLAFVTLP-AAINLLPIPYILGPLF 362
Query: 357 FLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING--YLDQ 414
FL L AG +S I++ +T+ L + LG SRK IV I FL+ + G LD
Sbjct: 363 FLALVVAGLSSHISIMEAVTSALIDKLGWSRKKAANIVIGIGFLVSMAFATNGGLLLLDL 422
Query: 415 VDAWISFQLALLA--LFDIIVGVWLFKPDNFWKELHEGALINVPEFY----KWITVIIAP 468
VD + + + ++A L ++++ WL K + K ++ + +V ++ ++++ +I
Sbjct: 423 VDHFAN-NVGIMASCLVELVLMTWLLKISDVRKYVNSISDFSVGVWFDICLRFVSPVILA 481
Query: 469 IFIALPLFGTFTD---LVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKY 514
I +A L FT+ TLGW I A+L+IG + + K+ Y
Sbjct: 482 IIVATKLQALFTEGYGGYDLTLGW---AIIAALLVIGILINASSRKEAY 527
>sp|P44849|Y736_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER HI0736
>gi|1075315|pir||E64089 probable transport protein
HI0736 - Haemophilus influenzae (strain Rd KW20)
>gi|1573742|gb|AAC22395.1| (U32757) sodium-dependent
transporter, putative [Haemophilus influenzae Rd]
Length = 508
Score = 176 bits (443), Expect = 4e-43
Identities = 144/518 (27%), Positives = 241/518 (45%), Gaps = 69/518 (13%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
++R+ ++ + ILA G+A+GLGN RFP NGGGAF++PY +AL GIP+++++
Sbjct: 9 QKRETFSGRRAFILAAIGSAVGLGNIWRFPYTTYENGGGAFIIPYLIALLTAGIPLLFLD 68
Query: 69 WVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
+ G R G + P F + G ++ YY +
Sbjct: 69 YAIGHRHRGGAPLSYRRFSPHFEVF-----------------GWWQMMVNVIIGLYYAVV 111
Query: 126 IGWSAAYSWFSISGAYFNVE---STAKFFESYLSNHGLVFLFWG-ITVVLLA---IAVG- 177
+GW+A+Y++FS +GA+ + KF + +G+ F F G +T L+A +A+G
Sbjct: 112 LGWAASYTYFSFTGAWGDKPIDFFIGKFLKMGDIKNGISFEFVGMVTAPLIAMWIVALGV 171
Query: 178 --QGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYL 235
GV KGI + V+MP+L V ++LVIY L KG + +++P+W+ L
Sbjct: 172 LSMGVQKGIAKVSSVLMPVLVVMFMVLVIYSLFLP--------GAAKGLDALFTPDWSKL 223
Query: 236 KEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGS 295
SV +AA GQIFF+LS+G GI+ YASYL + D+ SGL N EV+ G
Sbjct: 224 SNP--SVWIAAYGQIFFSLSIGFGIMVTYASYLKKESDLTGSGLVVGFANSSFEVLAGIG 281
Query: 296 IAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGAL 355
+ L + +AKG G+G ++ + P I + G G L
Sbjct: 282 VFAALGFIATAQGQEVSEVAKG------------GIGLAFFAFPTI-INKAPFGEVLGML 328
Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQV 415
+F L FA TS I++ + + +++ + ISR T+IV + L+ + + L +
Sbjct: 329 FFGSLTFAALTSFISVIEVIISAIQDKIRISRGKVTFIVGVPMMLVSVILFGTTTGLPML 388
Query: 416 DAWIS----FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
D + F + +A +I V K L+E + V F++ + +++ +
Sbjct: 389 DVFDKFVNYFGIVAVAFASLIAIVANEKLGLLGNHLNETSSFKVGFFWR-LCIVLTSGVL 447
Query: 472 ALPLFGTFTDLVSK-----------TLGWPAKIAIIAM 498
A LF + S+ T GW I+++ +
Sbjct: 448 AFMLFSEGAKVFSEGYEGYPNWFVNTFGWGMSISLLVV 485
>dbj|BAB04847.1| (AP001511) sodium-dependent transporter [Bacillus halodurans]
Length = 453
Score = 169 bits (425), Expect = 5e-41
Identities = 133/413 (32%), Positives = 197/413 (47%), Gaps = 49/413 (11%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
Q R++WA+++G ILA G+A+GLGN RF NGG AF++ Y + L+GIP++
Sbjct: 5 QQTGREQWASRLGFILAAMGSAVGLGNIWRFSYVTGENGGAAFLLVYLGFIALIGIPIVL 64
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKP-RSALIFGLIGGALAFATTTLLNSYYLHL 125
E+ GR G+ E L P + + GL+G A F L+ S+Y +
Sbjct: 65 AEFTIGRRAQSDAVGSF---------EKLAPGKPWKVAGLMGVAAGF----LILSFYGVI 111
Query: 126 IGWSAAYSWFSISGAYFN--VESTAKFFESYLSNHGLVFLFWGITVVLLAI-AVGQGVSK 182
GW Y + I+G ++ E FFE +++N L LFW ++ I V GV K
Sbjct: 112 AGWILFYLFNYITGQLWSAPAEGFGGFFEGFIANPTLP-LFWQALFMIATIWIVAIGVKK 170
Query: 183 GIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSV 242
GIER K++MPLL V + L IY LG +G F++SP+W+ LK+ V
Sbjct: 171 GIERSNKILMPLLGVLLIALAIYSLTLG--------GAKEGLAFLFSPDWSALKDP--GV 220
Query: 243 MLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAV 302
LAA Q FFTLSLGMG + Y SY+ + + ++ L+ ++ G
Sbjct: 221 YLAAISQAFFTLSLGMGALITYGSYVSKDSRLPGAAVSVAGLDTAFAIIAG--------- 271
Query: 303 AYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWF 362
++ P V A G +S + G G + LP+IF + G G +F+LL
Sbjct: 272 ----IMIFPAVFALG-------LSPSGGPGLVFVVLPDIFDSI-RLGPIVGIAFFILLGA 319
Query: 363 AGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQV 415
A +SA+++ A SRK + +I LLGIP G L +V
Sbjct: 320 AALSSAVSLLEVPVAYFMRKFDWSRKQAAITLGVIITLLGIPSSLSFGVLGEV 372
>pir||G82096 sodium-dependent transporter VC2283 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9656846|gb|AAF95427.1|
(AE004299) sodium-dependent transporter [Vibrio
cholerae]
Length = 451
Score = 166 bits (415), Expect = 8e-40
Identities = 130/489 (26%), Positives = 230/489 (46%), Gaps = 57/489 (11%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
Q R+ +++++G ILA AG A+GLGN FPTQ A NGGGAF++ Y + +F++ P++
Sbjct: 3 QSNSRETFSSRLGFILAAAGAAVGLGNIWGFPTQAASNGGGAFLLVYLILIFVVAFPMLV 62
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
VE GRY G P + + S +P + + G +G + + + + ++Y +
Sbjct: 63 VEMAIGRY------GQANPVDSMRSLTS-QPAAKKVGGFVGW-VGLSVPSAVLAFYSIVG 114
Query: 127 GWSAAYSWFSISGAYFNVESTAKFFESYLSNHGL--VFLFWGITVVLLAIAVGQGVSKGI 184
GW + +++ F + + + + + L +F+ +T+++ V GV +GI
Sbjct: 115 GWIICFLLGAMTD-LFGFTAASAWLKGFSVERNLFGTLIFYVLTILI----VQGGVKQGI 169
Query: 185 ERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVML 244
ERW +MP L+V +L IY+ + I FE +W ++L
Sbjct: 170 ERWSTRLMPALFVLFAVLFIYIMTQQGAWEGLKHYLIPDFEKVWDR----------KLIL 219
Query: 245 AASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAY 304
AA GQ FF+L++G + Y SYL K+++ + +V+L + A + G + +P
Sbjct: 220 AAMGQGFFSLTIGGCSMLIYGSYLSKKENLPKMAM-SVTLVDTAVAFIAGLVVLP----- 273
Query: 305 APKIVPPEVLAKGSNAALQWISENFGLGFS----YTSLPNIFVQMGTAGRFFGALWFLLL 360
+ N +Q +++ L S +T LP +F +G G+ F ++FLLL
Sbjct: 274 --------AMFVAMNKGVQIYAQDGSLLSSDTLVFTVLPLMFDSLGLLGQIFAMVFFLLL 325
Query: 361 WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS 420
A TS+I+M AL+ E R +W++ + L + +VY G L + A ++
Sbjct: 326 TIAALTSSISMLECPVALVGERFNTRRTPTSWVLGGLIALFSVVIVYNFGALFGLVATLA 385
Query: 421 FQL--ALLALFDIIVGVWLFKPDNFWKELHEGALINVPE--------FYKWITVIIAPIF 470
Q AL + G W+++ D KEL G PE + W + P+
Sbjct: 386 TQYLQPTAALMFCLFGGWVWQRDAKMKELQAG----FPELQQSLFGKIWPWYVKFVCPVL 441
Query: 471 IALPLFGTF 479
+A ++ +F
Sbjct: 442 VATVIWASF 450
>pir||B82171 probable sodium-dependent transporter VC1669 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9656184|gb|AAF94819.1| (AE004245) sodium-dependent
transporter, putative [Vibrio cholerae]
Length = 448
Score = 161 bits (404), Expect = 2e-38
Identities = 125/475 (26%), Positives = 224/475 (46%), Gaps = 46/475 (9%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R ++ ++ G I+A AG+A+GLGN FPTQ A NGG F++ Y +FLL P++ E
Sbjct: 10 RGQFTSRFGFIMAAAGSAVGLGNVWGFPTQAASNGGAVFLLVYLCMVFLLAYPMLVAELT 69
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPR---SALIFGLIGGALAFATTTLLNSYYLHLIG 127
GRY G + + A S+ P+ A++ G+IG +L+ S+Y + G
Sbjct: 70 IGRY---------GQSNPIRAFRSVWPQGKWGAILLGVIG----MVVVSLILSFYAIVAG 116
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
W S F +S +++ S+ + L+ + +VL V GV+ GIE+W
Sbjct: 117 WLVG-SLFGSGLTLIGADSASQWLTSFSTERNLILMV--SFMVLTMFVVRNGVANGIEKW 173
Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
+MPLL+V +L +Y+F Q + G + P+ ++ V+++A
Sbjct: 174 STRLMPLLFVLFGLLTVYIFT--------QEGALDGLKMYLVPDLSHFTP---DVVVSAM 222
Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
GQ FF+LSLG+ ++ Y SYL + ++ + A V+L + + G + +P + K
Sbjct: 223 GQAFFSLSLGVCVMTTYGSYLNKEANLPKTA-AQVALIDTGVAFIAGLMVLP--AMFVAK 279
Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
E+ + + ++ + +T LP +F MG G G ++FLL+ A TS
Sbjct: 280 HNGVEIFSSSG----ELLNSD---TLVFTVLPAMFDTMGAVGAVIGIIFFLLMIIAALTS 332
Query: 368 AIAMYNYLTALLEEDLGISRKTGT-WIVFIIYFLLGIPVVYINGYLDQVDAWIS-FQLAL 425
+I+M A E+L R + WI ++ + G+ V+ + V + + + +
Sbjct: 333 SISMLEVPVACAVEELQQKRSSAVLWIGGLVTIISGVIVLNFSSLFGLVINFTTVYSQPI 392
Query: 426 LALFDIIVGVWLFKPDNFWKELHEGAL-INVPEFYK---WITVIIAPIFIALPLF 476
+AL ++ W++ + EL +G I F+K W ++ P+ + + F
Sbjct: 393 IALLITLIAGWIWNRNQILSELKQGCPDIENSLFWKIWPWYVRLVCPVLMLMVFF 447
>pir||E81964 probable sodium-dependent inner membrane transport protein NMA0470
[imported] - Neisseria meningitidis (group A strain
Z2491) >gi|7379216|emb|CAB83765.1| (AL162753) putative
sodium-dependent inner membrane transport protein
[Neisseria meningitidis Z2491]
Length = 511
Score = 156 bits (390), Expect = 7e-37
Identities = 137/508 (26%), Positives = 237/508 (45%), Gaps = 76/508 (14%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
++R + T+ ++A G+A+GLGN RFP NGGGAF++PY +AL GIP++ ++
Sbjct: 7 KERATFGTRRAFMIAAIGSAVGLGNIWRFPYIAFENGGGAFILPYLVALLTAGIPLLLLD 66
Query: 69 WVQG-RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
+ G RY G P + +P G T ++ YY +IG
Sbjct: 67 YAIGHRYRGS------APLAFRRLGRWFEP---------VGWWNVMTNIVICIYYAVIIG 111
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFL--------------FWGITVVLLA 173
W+A+Y+++S++ A+ + FF+ +L G L W T ++A
Sbjct: 112 WAASYTYYSVNAAW-GADPQGFFFKDFLQMAGPEALGLDFVGKVAGPLAGVWVFTAAIMA 170
Query: 174 IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWT 233
+ GV KG+ R MPLL LV+++ +G L P KG + +++P+W+
Sbjct: 171 L----GVQKGVARASSFFMPLL------LVMFLIMVGISLTLP--GAAKGLDALFTPDWS 218
Query: 234 YLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLG 293
L + V +AA GQIFF+LS+ GI+ Y+SYL K D+ +GL N E++ G
Sbjct: 219 KLADS--KVWVAAYGQIFFSLSICFGIMVTYSSYLKKKTDLGGTGLVVGFANSSFELLAG 276
Query: 294 GSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFG 353
I V A+ + +A+ A+ ++ G+G ++ + P I + G G
Sbjct: 277 --IGVFAALGF---------MAQAGGKAVNEVASG-GIGLAFIAFPTI-INQAPMGWLIG 323
Query: 354 ALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLL---------GIP 404
L+F L FAG TS I++ + A +++ L I R T +V I ++ G+P
Sbjct: 324 ILFFGSLVFAGVTSMISILEVIVAAIQDKLNIGRVNATLLVCIPMGIVSTLLFGTATGLP 383
Query: 405 VVYINGYLDQVDAWISFQLALLALFDIIVGVWLF-KPDNFWKELHEGALINVPEFYKWIT 463
V LD +D +++ + A F + + + + K L+ + I + + +
Sbjct: 384 V------LDVMDKFVNTYGIVAAGFVYVAAIIISGRLPELRKHLNALSSIRIGGLWT-VC 436
Query: 464 VIIAPIFIALPLFGTFTDLVSKTL-GWP 490
V++ + + LF + L+ K G+P
Sbjct: 437 VVVTVVMLGYMLFKDTSGLMEKNYEGYP 464
>pir||H81019 sodium- and chloride-dependent transporter NMB1975 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7227236|gb|AAF42303.1| (AE002546) sodium- and
chloride-dependent transporter [Neisseria meningitidis
MC58]
Length = 511
Score = 156 bits (390), Expect = 7e-37
Identities = 137/508 (26%), Positives = 237/508 (45%), Gaps = 76/508 (14%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
++R + T+ ++A G+A+GLGN RFP NGGGAF++PY +AL GIP++ ++
Sbjct: 7 KERATFGTRRAFMIAAIGSAVGLGNIWRFPYIAFENGGGAFILPYLVALLTAGIPLLLLD 66
Query: 69 WVQG-RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
+ G RY G P + +P G T ++ YY +IG
Sbjct: 67 YAIGHRYRGS------APLAFRRLGRWFEP---------VGWWNVMTNIVICIYYAVIIG 111
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFL--------------FWGITVVLLA 173
W+A+Y+++S++ A+ + FF+ +L G L W T ++A
Sbjct: 112 WAASYTYYSVNAAW-GADPQGFFFKDFLQMAGPEALGLDFVGKVAGPLAGVWVFTAAIMA 170
Query: 174 IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWT 233
+ GV KG+ R MPLL LV+++ +G L P KG + +++P+W+
Sbjct: 171 L----GVQKGVARASSFFMPLL------LVMFLIMVGISLTLP--GAAKGLDALFTPDWS 218
Query: 234 YLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLG 293
L + V +AA GQIFF+LS+ GI+ Y+SYL K D+ +GL N E++ G
Sbjct: 219 KLADS--KVWVAAYGQIFFSLSICFGIMVTYSSYLKKKTDLGGTGLVVGFANSSFELLAG 276
Query: 294 GSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFG 353
I V A+ + +A+ A+ ++ G+G ++ + P I + G G
Sbjct: 277 --IGVFAALGF---------MAQAGGKAVNEVASG-GIGLAFIAFPTI-INQAPMGWLIG 323
Query: 354 ALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLL---------GIP 404
L+F L FAG TS I++ + A +++ L I R T +V I ++ G+P
Sbjct: 324 ILFFGSLVFAGVTSMISILEVIVAAIQDKLNIGRVNATLLVCIPMGIVSTLLFGTATGLP 383
Query: 405 VVYINGYLDQVDAWISFQLALLALFDIIVGVWLF-KPDNFWKELHEGALINVPEFYKWIT 463
V LD +D +++ + A F + + + + K L+ + I + + +
Sbjct: 384 V------LDVMDKFVNTYGIVAAGFVYVAAIIISGRLPELRKHLNALSSIRIGGLWT-VC 436
Query: 464 VIIAPIFIALPLFGTFTDLVSKTL-GWP 490
V++ + + LF + L+ K G+P
Sbjct: 437 VVVTVVMLGYMLFKDTSGLMEKNYEGYP 464
>pir||F81050 sodium- and chloride-dependent transporter NMB1707 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226963|gb|AAF42055.1| (AE002521) sodium- and
chloride-dependent transporter [Neisseria meningitidis
MC58]
Length = 445
Score = 155 bits (387), Expect = 1e-36
Identities = 127/486 (26%), Positives = 204/486 (41%), Gaps = 70/486 (14%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
M W++KIG +LA AG+AIGLG +FP NGG F + + + L+ +PV
Sbjct: 1 MSNHTSWSSKIGFVLAAAGSAIGLGAIWKFPYTAGTNGGAVFFLLFLIFTILVALPVQLA 60
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
E+ GR GGK + L+P + ++ G + A +L S+Y + G
Sbjct: 61 EFYIGRTGGKNAVDSF---------RVLRPGTQWLW---VGRMGVAACFILLSFYSVVGG 108
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
W Y S +GA F + +SN + + +++ V G+S GIE+
Sbjct: 109 WVLNYVVHSFTGAVHTGADFEALFGATISNPAGSLSYQALFMLITVWVVKGGISDGIEKA 168
Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
+ +MP L++ + L I L ++G F+ PNW+Y K M+ A
Sbjct: 169 NRYLMPGLFILFIALAIRSLTLP--------GAMEGVSFLLKPNWSYFKA---DTMITAL 217
Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
GQ FF LS+G+ + YASYLG D+ SG + +N ++ G
Sbjct: 218 GQAFFALSIGVSAMITYASYLGKDQDMFRSGHTIMWMNLLVSLLAG-------------L 264
Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
++ P V A G + G G + LP +F++M G A++ LL+ FA TS
Sbjct: 265 VIFPAVFAFG-------FEPSQGPGLIFIVLPAVFMKM-PFGTVLFAVFMLLVVFATLTS 316
Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
A +M + A RK TW++ F++GIP G W F++
Sbjct: 317 AFSMLETVIASTIRQDERKRKKHTWLIGTAIFIIGIPSALSFG------VWGEFKVFGKT 370
Query: 428 LFDI------------------IVGVWLFKPDNFWKELHEGALINVPEFYKWITVI--IA 467
+FD+ I W+ + K+ G+ + W+ + +A
Sbjct: 371 IFDLWDYVISAVIMPIGALSVSIFTAWIQDKQSVLKDAGAGSTVPRAVLLLWLNTLRYLA 430
Query: 468 PIFIAL 473
PI I +
Sbjct: 431 PIAIII 436
>pir||G81824 probable integral membrane ion transporter NMA1961 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7380593|emb|CAB85181.1| (AL162757) putative integral
membrane ion transporter [Neisseria meningitidis Z2491]
Length = 445
Score = 154 bits (386), Expect = 2e-36
Identities = 118/424 (27%), Positives = 186/424 (43%), Gaps = 50/424 (11%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
M W++KIG +LA AG+AIGLG +FP NGG F + + + L+ +PV
Sbjct: 1 MSNHTSWSSKIGFVLAAAGSAIGLGAIWKFPYTAGTNGGAVFFLLFLIFTILVALPVQLA 60
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
E+ GR GGK + L+P + ++ G + A +L S+Y + G
Sbjct: 61 EFYIGRTGGKNAVDSF---------RVLRPGTQWLW---VGRMGVAACFILLSFYSVVGG 108
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
W Y S +GA F + +SN + + +++ V G+S GIE+
Sbjct: 109 WVLNYVVHSFTGAVHTGADFEALFGATISNPAGSLSYQALFMLITVWVVKGGISDGIEKA 168
Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
+ +MP L++ + L I L ++G F+ PNW+Y K M+ A
Sbjct: 169 NRYLMPGLFILFIALAIRSLTLP--------GAMEGVSFLLKPNWSYFKA---DTMITAL 217
Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
GQ FF LS+G+ + YASYLG D+ SG + +N ++ G
Sbjct: 218 GQAFFALSIGVSAMITYASYLGKDQDMFRSGHTIMWMNLLVSLLAG-------------L 264
Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
++ P V A G + G G + LP +F++M G A++ LL+ FA TS
Sbjct: 265 VIFPAVFAFG-------FEPSQGPGLIFIVLPAVFMKM-PFGTVLFAVFMLLVVFATLTS 316
Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
A +M + A RK TW++ F++GIP G W F++
Sbjct: 317 AFSMLETVIAATIRQDERKRKKHTWLIGTAIFIVGIPSALSFG------VWGEFKVFGKT 370
Query: 428 LFDI 431
+FD+
Sbjct: 371 IFDL 374
>gb|AAG19816.1| (AE005066) sodium- and chloride-dependent transporter; Nac
[Halobacterium sp. NRC-1]
Length = 477
Score = 152 bits (381), Expect = 8e-36
Identities = 139/516 (26%), Positives = 221/516 (41%), Gaps = 60/516 (11%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
RD W +++G I+A G+A+GLGN RFP + NGG AF++ Y + +G+P + E+V
Sbjct: 3 RDVWHSRLGFIMAAVGSAVGLGNLWRFPWMTSENGGAAFLLVYLGVVLCVGVPGLLAEFV 62
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
GR + G + S + G L+ +L S+Y + GW
Sbjct: 63 IGRRSRRSPVG------------AFSSLSDSTLWRVFGHLSVVIAVVLLSFYSVVGGWIL 110
Query: 131 AYSWFSISGAYFNVESTAKFFESY-LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVK 189
Y S++GAYF+ SY L G LF IT + V +G+ +GIE K
Sbjct: 111 RYFGASLTGAYFSNPGQYFATVSYGLDAVGFHLLFLAIT----GLIVVRGIKRGIENATK 166
Query: 190 VMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQ 249
+MMP + V ++L + L G F SP+ L+ L ++ AA+GQ
Sbjct: 167 LMMPAVVVLLIVLAAWASTLD--------GAGAGLAFYLSPDVELLEADLLGILPAAAGQ 218
Query: 250 IFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIV 309
FTLSLG G + YASYL + +A G A LN VL G + PL
Sbjct: 219 ALFTLSLGSGTMITYASYLDEERSLAADGAAIAVLNTCIG-VLAGLVVFPLLF------- 270
Query: 310 PPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI 369
AL + G G + L N FV + GR GA++F ++ A +S+I
Sbjct: 271 -----------ALVGDAGTGGPGALFVGLANAFVAV-PYGRAVGAVFFAVVSLAAISSSI 318
Query: 370 AMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALF 429
+M + L ++ G+SR+ T + ++ + G G D V + L L
Sbjct: 319 SMLELPVSFLVDEYGVSRRRATALFVGVFTVTGSATALSPGLFDFVAGTLVDLLMTAGLI 378
Query: 430 DIIVGVWLFKPDNFWKELHEGA-----LINVPEFYK--------WITVIIAPIFIALPLF 476
++ N E GA ++ P Y I +++ I AL +
Sbjct: 379 GFLLFTGWVVGQNAVTEYELGAGAVASALSTPWLYAVGVVIPVFLIFTLVSGIAAALGVS 438
Query: 477 GTFTDLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKK 512
T +L T+ P A ++++I A+ ++ +++
Sbjct: 439 ITAVELWGVTISQPRLFAGLSVVI--AVVSFLGLRR 472
>pir||T46663 probable sodium/chloride ion channel [imported] - Neisseria
meningitidis >gi|4433817|gb|AAD20893.1| (U58765)
putative sodium/chloride ion channel [Neisseria
meningitidis]
Length = 445
Score = 152 bits (380), Expect = 1e-35
Identities = 116/424 (27%), Positives = 187/424 (43%), Gaps = 50/424 (11%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
M W++KIG +LA AG+AIGLG +FP NGG F + + + L+ +PV
Sbjct: 1 MSNHTSWSSKIGFVLAAAGSAIGLGAIWKFPYTAGTNGGAVFFLLFLIFTVLVALPVQLA 60
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
E+ GR GG+ + +L+P + ++ G + + +L S+Y + G
Sbjct: 61 EFYIGRTGGQNAVDSF---------RALRPSTQWLW---VGRMGVSACFILLSFYSVVGG 108
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
W Y S +GA F + +SN + + +++ V G+S GIE+
Sbjct: 109 WVLNYVVHSFTGAVHTGADFEALFGATISNPAGSLSYQALFMLITVWVVKGGISDGIEKA 168
Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
+ +MP L++ + L I L ++G F+ PNW+Y K M+ A
Sbjct: 169 NRYLMPGLFILFIALAIRSLTLP--------GAMEGVSFLLKPNWSYFKA---DTMITAL 217
Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
GQ FF LS+G+ + YASYLG D+ SG + +N ++ G
Sbjct: 218 GQAFFALSIGVSAMITYASYLGKDQDMFRSGHTIMWMNLLVSLLAG-------------L 264
Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
++ P V A G + G G + LP +F++M G A++ LL+ FA TS
Sbjct: 265 VIFPAVFAFG-------FEPSQGPGLIFIVLPAVFMKM-PFGTVLFAVFMLLVVFATLTS 316
Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
A +M + A RK TW++ F++GIP G W F++
Sbjct: 317 AFSMLETVIASTIRQDERKRKKHTWLIGTAIFIVGIPSALSFG------IWGEFKVFGKT 370
Query: 428 LFDI 431
+FD+
Sbjct: 371 IFDL 374
>pir||D69902 sodium-dependent transporter homolog yocR - Bacillus subtilis
>gi|2619056|gb|AAB84480.1| (AF027868) putative
transporter [Bacillus subtilis]
>gi|2634327|emb|CAB13826.1| (Z99114) similar to
sodium-dependent transporter [Bacillus subtilis]
Length = 445
Score = 150 bits (376), Expect = 3e-35
Identities = 131/492 (26%), Positives = 223/492 (44%), Gaps = 67/492 (13%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
M++ ++W++K+G ILA AG+AIGLG +FP +GGGAF++ + L L+G+P++
Sbjct: 1 MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLLIFILFTVLIGLPLLLG 60
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
E++ GR K + + ++L P + + G L T +L S+Y + G
Sbjct: 61 EFIIGRRTQKDA---------VQSYKTLAPGTKWHW---IGYLGMVTCFILLSFYSVVGG 108
Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
W Y +G F S +SN L + +V+ + V +GVS GIE+
Sbjct: 109 WILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKGVSSGIEKA 168
Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
+V+MP L++ +IL++ L ++G +F P+ T + + +L A
Sbjct: 169 SQVLMPALFLLFIILMVRSVTLD--------GAMEGIKFFLMPDLTAIDA---NTILYAM 217
Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
GQ FF LS+G+ ++ Y++YL ++++ S ++ +N V+ G +I
Sbjct: 218 GQSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIF---------- 267
Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
P V + G + + G + LP +F QM G F + LL FA TS
Sbjct: 268 ---PAVFSFG-------LKPDQGPVLLFNVLPTVFNQM-PFGIIFLLAFLLLFLFAALTS 316
Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
A +M L A+L + RK W+ I F++G+P G L V F L++
Sbjct: 317 AFSMLEILVAVLSKGDINKRKRFAWLGGIAIFIVGVPSALSYGVLSDVTI---FHLSIFD 373
Query: 428 LFDIIVG----------VWLFKP-----DNFWKELHEGALINVPEFYKWITVI-----IA 467
D +V + +F P + + EL G+ + F W+ +I +A
Sbjct: 374 AADYLVSNILMPLGALLISIFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVA 433
Query: 468 PIFIALPLFGTF 479
I + L + G F
Sbjct: 434 IIIVFLHVIGIF 445
>pir||F69825 sodium-dependent transporter homolog yhdH - Bacillus subtilis
>gi|2226203|emb|CAA74492.1| (Y14082) hypothetical
protein [Bacillus subtilis] >gi|2633282|emb|CAB12786.1|
(Z99109) similar to sodium-dependent transporter
[Bacillus subtilis]
Length = 451
Score = 150 bits (375), Expect = 4e-35
Identities = 139/486 (28%), Positives = 219/486 (44%), Gaps = 67/486 (13%)
Query: 13 KWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQG 72
+WA+KIG ++A AG+AIGLG +FP NGGGAF + + L LLG P++ E++ G
Sbjct: 8 QWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAFFLIFVLFTILLGYPLLVGEFIFG 67
Query: 73 RYGGKYGHGTLGPTFYLMARESLKPRSA-LIFGLIGGALAFATTTLLNSYYLHLIGWSAA 131
R T + A + PRSA + G IG A F L+ S+Y + GW
Sbjct: 68 R---------RNQTNAIDAYKKEAPRSAWFLTGWIGVAACF----LVLSFYSVIGGWILL 114
Query: 132 YSWFSISGAYFNVEST--AKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVK 189
Y + SG+ + F S + N + + L + V +GV KGIER
Sbjct: 115 YIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLVVARGVQKGIERVSA 174
Query: 190 VMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQ 249
VMMP+L++ ++LV+ L ++G +F+ P++ L +L A GQ
Sbjct: 175 VMMPILFLLFILLVLRSLTLN--------GAMEGVKFLLVPHFGDLTP---ESILFALGQ 223
Query: 250 IFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIV 309
FFTL+LG+ ++ Y+SYL ++ S + V +N ++ G +I
Sbjct: 224 AFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIF------------ 271
Query: 310 PPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLW-FAGFTSA 368
P V + G N G +T LP +F Q+ FF + FL+ + FA TSA
Sbjct: 272 -PAVFSFG-------FQPNEGPTLLFTVLPAVFEQLPFGTLFF--IGFLVAFLFAALTSA 321
Query: 369 IAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAW--ISFQLALL 426
+M + A + + RK +W ++ FL+GIP G L V + F +A
Sbjct: 322 FSMVEIIVATIGKGDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADF 381
Query: 427 ALFDIIVG-----VWLFKPDNFWK-----ELHEGALINVPEFYKWITVI-----IAPIFI 471
+ ++++ + LF P K E+ G+ FY W ++ +A I +
Sbjct: 382 TVSNVLMPSGALLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIV 441
Query: 472 ALPLFG 477
L L G
Sbjct: 442 FLNLIG 447
>dbj|BAB03936.1| (AP001507) sodium-dependent transporter [Bacillus halodurans]
Length = 457
Score = 148 bits (370), Expect = 1e-34
Identities = 131/479 (27%), Positives = 213/479 (44%), Gaps = 60/479 (12%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
+ +W++K+ ILA AG+A+GLG +FP +GGGAF + + L L+G+P++ E+V
Sbjct: 2 KQQWSSKLAFILAAAGSAVGLGAIWKFPYVTGTSGGGAFFLIFILFTLLIGLPLLIGEFV 61
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
GR K + + ++ P S+ +G + G L T LL S+Y + GW
Sbjct: 62 IGRSTQKNA---------IESYRAIAPNSS--WGGV-GKLGIFTCFLLLSFYSVIGGWII 109
Query: 131 AYSWFSISGAYFNVES--TAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWV 188
Y +I+G ++ + F +SN L + ++ V +GV KGIER
Sbjct: 110 IYFLKAITGQLSGLDEGRYGEIFAETISNPILAISSQFAFLAIVMYVVSRGVKKGIERAS 169
Query: 189 KVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASG 248
+MMP L+V + +VI L +G F P+++ + +L A G
Sbjct: 170 VIMMPALFVLFLAIVIRGLTLD--------GATEGLAFFLVPDFSTITS---ETLLYAMG 218
Query: 249 QIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKI 308
Q FF LS+G+ ++ Y+SYL + + S L+ V L F L G P ++
Sbjct: 219 QSFFALSVGVSVMVTYSSYLSRDESIVQSALSIVMLT-FVVAFLAGVAIFPAVFSFG--- 274
Query: 309 VPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA 368
+S + G + LP++F QM G FF + LL FA TSA
Sbjct: 275 ----------------MSPDEGPVLLFNVLPSVFDQM-PYGAFFLVTFLLLFLFATLTSA 317
Query: 369 IAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP-----------VVYINGYLDQVDA 417
+M + A + + R TW++ + F +GIP +++ D D
Sbjct: 318 FSMLEVVVAAITKGDVSQRPKVTWLIGLAIFAVGIPSALSYGVWSDVLLFGRTVFDTADF 377
Query: 418 WISFQLALLALFDIIVGVWL-FKPDNFWKELHEGALINVPEFYKWITVI--IAPIFIAL 473
+S L + I + V L + ++E+ GA I F W +I +API IA+
Sbjct: 378 LVSNILMPIGALLIAIFVPLKISKERLYEEIKAGASIGKRLFAIWFILIRYVAPIVIAI 436
>dbj|BAB07158.1| (AP001518) sodium-dependent transporter [Bacillus halodurans]
Length = 505
Score = 148 bits (370), Expect = 1e-34
Identities = 149/515 (28%), Positives = 232/515 (44%), Gaps = 62/515 (12%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R++W T+ G ILA G+A+GLGN RFP NGGGAF +PY AL GIP++ +E+
Sbjct: 2 REQWGTRAGFILAAVGSAVGLGNIWRFPYVAYENGGGAFFIPYLFALLTAGIPLLIMEFT 61
Query: 71 QG-RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G +Y G P Y + A G A++F T YY +I W+
Sbjct: 62 IGQKYRGS------APLSYARLN-----KKAEWIGWWQVAISFVIAT----YYAVIIAWA 106
Query: 130 AAYSWFSISGAYFNVESTAKF-FESYLS---NHGLV-FLFWGITVVLL---AIAVG---Q 178
+YS F+I+ ++ E T F F YL + G + L G+ + L+ +A+G
Sbjct: 107 MSYSVFAINLSW--GEDTGGFLFGEYLKLDVDPGQIGSLVPGVFIPLVLVWIVALGVLFA 164
Query: 179 GVSKGIERWVKVMMPLLYVFAVILVIYVFAL-GSPLGQPQWSTIKGFEFIWSPNWTYLKE 237
GV KGIE ++ +P L + +I+VI L G+ + G + + P+W+ +
Sbjct: 165 GVKKGIELANRIFIPTLVIMFLIIVIRAVTLEGAAI---------GLDAFFKPDWSEILS 215
Query: 238 HLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLG-GSI 296
V +AA GQIFF+LS+ I+ Y+SYL K DV + N E++ G G
Sbjct: 216 P--GVWVAAYGQIFFSLSIAFAIMITYSSYLPRKADVNNNAFIAGFSNSGFELLAGIGVF 273
Query: 297 AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALW 356
AV +A EV A G+G ++ P I + FG L+
Sbjct: 274 AVLGFMATQAGTTVGEVAAG-------------GIGLAFVVFPQIINSLPGLNGLFGFLF 320
Query: 357 FLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING--YLDQ 414
F L FAG +S I++ + L++ ISR + L+ + G LD
Sbjct: 321 FASLVFAGLSSLISIVETFVSALQDKFKISRTKAVLFGGGLSALISLLFATQGGLFLLDA 380
Query: 415 VDAWI-SFQLALLALFDIIVGVWLFKPDN-FWKELHEGALINVPEFYKWITVIIAPIFIA 472
D +I SF +AL L ++ W FK N K +E + + ++K +I PI +
Sbjct: 381 ADHFINSFGVALAGLVSVVAVSWFFKQLNPLQKHGNEVSDLRTGTWWKVCLGVITPIVLG 440
Query: 473 LPLFGTFTDLVSKTL-GWPAKIAIIA--MLIIGAI 504
+ +S+ G+P + + + +GAI
Sbjct: 441 YMAVQNIINSISENYEGYPTSFLLYSGWGVAVGAI 475
>pir||F81367 probable transmembrane transport protein Cj0935c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968372|emb|CAB73192.1| (AL139076) putative
transmembrane transport protein [Campylobacter jejuni]
Length = 444
Score = 145 bits (361), Expect = 2e-33
Identities = 112/390 (28%), Positives = 189/390 (47%), Gaps = 43/390 (11%)
Query: 16 TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
+KIG ILA+AG+A+GLGN +FPT V +GG AF++ Y + +G + E G+
Sbjct: 6 SKIGFILAVAGSAVGLGNAWKFPTLVGQSGGSAFILLYIILTLGVGFVIFLAELSIGKIS 65
Query: 76 GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
K + A E L P + + +G + A L+ S+Y +IGW Y +
Sbjct: 66 EKDP---------VNAYEKLAPSNKKAWSYVGFTMVGAI--LIVSFYTLVIGWIVKYVFL 114
Query: 136 SISGAY-FNVESTAKFFESYLSNHGLV-FLFWGITVVLLAIAVGQGVSKGIERWVKVMMP 193
SI+G ++E + F ++S L F+ + + + + V +GV GIE+ MMP
Sbjct: 115 SITGNLPMDLEVSKAQFGFFISEDFLSQFICFTLVFLCVFYIVSKGVKNGIEKLNVWMMP 174
Query: 194 LLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFT 253
L++ +++++Y + I +F++ P+++ + S +L A G FF+
Sbjct: 175 SLFILLILMLVYAISKDG--------FIMAVKFLFVPDFSKINT---SNVLEALGLAFFS 223
Query: 254 LSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEV 313
LSLG+G I Y++ L K + S L + +N +++G +V +
Sbjct: 224 LSLGVGTIITYSASLPDKTNFITSTLNIIFINLLVGLLMG-------------LVVFTFI 270
Query: 314 LAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYN 373
G N Q G G + SL +F ++G G FGA +F+ L FAG TSA++M
Sbjct: 271 FEFGYNPNQQ------GPGLVFISLATLFEKIGVIGCIFGAAFFISLIFAGITSAVSMIE 324
Query: 374 YLTALLEEDLGISRKTGTWIVFIIYFLLGI 403
T L G+SRK ++ I+ ++LG+
Sbjct: 325 PFTFYLINTFGMSRKKALILIGIVVYILGM 354
>pir||G71930 probable transporter - Helicobacter pylori (strain J99)
>gi|4154986|gb|AAD06028.1| (AE001479) putative
transporter [Helicobacter pylori J99]
Length = 442
Score = 140 bits (349), Expect = 4e-32
Identities = 128/474 (27%), Positives = 213/474 (44%), Gaps = 63/474 (13%)
Query: 16 TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
+K+G ILA G++IGLG+ RFP V NGG AF++ Y LGI ++ VE + G G
Sbjct: 5 SKLGFILATLGSSIGLGHIWRFPYMVGHNGGSAFVLLYLALTLSLGIAMLLVEMLIGNLG 64
Query: 76 GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
K + + ++ + K F ++GG L+ S+Y ++GW Y +
Sbjct: 65 KK----DVVSNYQILDPKRKKYYPFTSFFILGG-------PLILSFYAVVLGWVLYYLFV 113
Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIA--VGQGVSKGIERWVKVMMP 193
++E AK S L N L++ G + LL V +G+ KGIE+ V+MP
Sbjct: 114 VTFDLPKDLEQ-AKMQFSMLQNGSLIWPVIGFSACLLPTIWFVSRGIEKGIEKLNVVLMP 172
Query: 194 LLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFT 253
LL+V + L+IY L S K F+++ +++ + V++ A GQ+FF+
Sbjct: 173 LLFVIFIGLLIYAMTLE--------SMPKALRFLFN---FEIQKIDFKVVMDALGQMFFS 221
Query: 254 LSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEV 313
LSLG+G I Y+++ K+++ S L V ++ G I + +A
Sbjct: 222 LSLGVGTIITYSAFTPKKENLLKSSLFIVLPGILISLIAGVMIFTFVFEYHAD------- 274
Query: 314 LAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYN 373
+S+ G G + SLP F +MG +G+ +F+ L FAG TS +++
Sbjct: 275 -----------VSQ--GPGLVFISLPLTFAKMGISGQIVSLFFFMALVFAGITSTVSLIE 321
Query: 374 YLTALLEEDLGISR-KTGTWIVFIIYFLLGIPVVYIN---------------GYLDQVDA 417
L L SR K WI ++Y L + ++ +N G+LD + +
Sbjct: 322 PLALYLINRFNFSRLKASLWIGVVVYVLGVLVILSMNERYAKFLSFAHKSVFGWLDFITS 381
Query: 418 WISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
SF + L LF ++ W+ + N + + + IAP+ I
Sbjct: 382 --SFLMPLGGLFSVLFIGWILNKKRSFLATKHFFSANAFKAWHFSVRFIAPVVI 433
>sp|P45320|YG90_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER HI1690
>gi|1075054|pir||H64136 neurotransmitter transport
protein homolog - Haemophilus influenzae (strain Rd
KW20) >gi|1574543|gb|AAC23336.1| (U32842)
sodium-dependent transporter, putative [Haemophilus
influenzae Rd]
Length = 457
Score = 140 bits (349), Expect = 4e-32
Identities = 112/405 (27%), Positives = 192/405 (46%), Gaps = 45/405 (11%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
+QR W++++ ++ +AG +G G RFP V NGGGA+++ + +A+ ++GIP++ VE
Sbjct: 6 KQRQTWSSRLTYVMTVAGATVGFGATWRFPYLVGENGGGAYVLLFCIAMIVIGIPMILVE 65
Query: 69 WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
V GR G ++ + + I G +G AF + +YY+ L GW
Sbjct: 66 NVIGRRLRVNSIDAFGDK--ILDKGKGISKYWKILGYMGLLGAFG----IMAYYMVLGGW 119
Query: 129 SAAYSWFSISGAY-----FNVESTAKFFESYLSNHGLVFLFWGITVVLL-AIAVGQGVSK 182
+Y ISG + F++ ++ N +F+ + V++ I + +G+
Sbjct: 120 VISYIISLISGTLDISTPITKDIAKNFYDLHIGNSPYEIIFYTLLFVIVNYIILAKGIIG 179
Query: 183 GIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSV 242
GIER VK +MPLL++F + +VI L ++G F P+++ + L+
Sbjct: 180 GIERSVKYLMPLLFIFLIGMVIRNVTLP--------GAMEGITFYLKPDFSKITPQLFIF 231
Query: 243 MLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAV 302
+L GQ+FF LSLG G++ +SYL ++++ + + T N V+ G I
Sbjct: 232 VL---GQVFFALSLGFGVLITLSSYLNKEENLIHTAVITGFTNTIIAVLAGFMIF----- 283
Query: 303 AYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWF 362
P + G I N G + SLP +F + AG+FF ++F LL
Sbjct: 284 --------PSLFTFG-------IEPNAGPTLVFQSLPIVFSHL-WAGKFFAIIFFGLLLI 327
Query: 363 AGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLG-IPVV 406
A T++I +Y + L+E L + R + FLLG IP +
Sbjct: 328 AALTTSITIYEVIITALQEKLRMCRGKAIVLTLSGIFLLGNIPAI 372
>pir||B64582 sodium- and chloride-dependent transporter - Helicobacter pylori
(strain 26695) >gi|2313608|gb|AAD07563.1| (AE000564)
sodium- and chloride-dependent transporter [Helicobacter
pylori 26695]
Length = 442
Score = 138 bits (345), Expect = 1e-31
Identities = 129/477 (27%), Positives = 217/477 (45%), Gaps = 69/477 (14%)
Query: 16 TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
+K+G ILA G++IGLG+ RFP V NGG AF++ Y + LGI ++ VE + G G
Sbjct: 5 SKLGFILATLGSSIGLGHIWRFPYMVGHNGGSAFVLLYLVLTLSLGIAMLLVEMLIGNLG 64
Query: 76 GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
K + + ++ + K F ++GG L+ S+Y ++GW Y +
Sbjct: 65 KK----DVVSNYQILDPKRKKYYPFTSFFILGG-------PLILSFYAVVLGWVLYYLFV 113
Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIA--VGQGVSKGIERWVKVMMP 193
++E AK S L N L++ G + LL V +G+ +GIE+ V+MP
Sbjct: 114 VTFDLPKDLEQ-AKMQFSMLQNGSLIWPVIGFSACLLPTIWFVSRGIEEGIEKLNVVLMP 172
Query: 194 LLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFT 253
LL+V + L+IY L S K F+++ +++ + V++ A GQ+FF+
Sbjct: 173 LLFVIFIGLLIYAMTLE--------SMPKALHFLFN---FEIQKIDFKVVMDALGQMFFS 221
Query: 254 LSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEV 313
LSLG+G I Y+++ K+++ S L V ++ G I + +A
Sbjct: 222 LSLGVGTIITYSAFTPKKENLFKSSLFIVLPGILISLIAGVMIFTFVFEYHAD------- 274
Query: 314 LAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYN 373
+S+ G G + SLP F +MG +G+ +F+ L FAG TS +++
Sbjct: 275 -----------VSQ--GPGLVFISLPLTFAKMGMSGQIVSLFFFMALVFAGITSTVSLIE 321
Query: 374 YLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVY----------------INGYLDQVDA 417
L L SR + + ++ ++LG+ V+ + G+LD + +
Sbjct: 322 PLALYLINRFNFSRLQASLWIGVVVYVLGVLVILSMNERYAKFLSFAHKSVFGWLDFITS 381
Query: 418 WISFQLALLALFDIIVGVWLF-KPDNFWKELHEGALINVPEFYKWITVI--IAPIFI 471
SF + L LF ++ W+ K +F H N F W + IAP+ I
Sbjct: 382 --SFLMPLGGLFSVLFIGWILNKKRSFLATKH---FFNANAFKAWHFSVRFIAPVVI 433
>pir||E81367 probable transmembrane transport protein Cj0934c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968371|emb|CAB73191.1| (AL139076) putative
transmembrane transport protein [Campylobacter jejuni]
Length = 446
Score = 136 bits (340), Expect = 5e-31
Identities = 120/464 (25%), Positives = 207/464 (43%), Gaps = 46/464 (9%)
Query: 16 TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
+KIG +L +AG A+GLGN +FPT A NGG F++ Y +G + E GR
Sbjct: 6 SKIGFVLTVAGGAVGLGNAWKFPTLSAENGGFVFVLLYLFFTLTIGFSIFLAEVAMGRLS 65
Query: 76 GKYGHGTLGPTFYLMA-RESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSW 134
L + +A + + R +F ++GG S+YL ++GW Y+
Sbjct: 66 ----KSDLANAYSNLAIKYGNRWRYGGVF-MLGGIFVL-------SFYLVIMGWVLKYTV 113
Query: 135 FSISGAYFNVESTAKFFESYLSNH--GLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMM 192
S+ ++ A F++ ++ + VF F+ ++ L + V +G+ KGIE+ V+M
Sbjct: 114 VSLYYLPKTLDEAASNFQNLITTNLTSSVF-FFTLSFFLTLLIVSKGLIKGIEKLNVVIM 172
Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFF 252
P L++ V ++ Y F +++ P++ + K +S + A G FF
Sbjct: 173 PSLFLMLVFMLFYCMGFKQGFAN-------AFSYLFYPDFLHFK---FSSIAEALGLAFF 222
Query: 253 TLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPE 312
TL LG+G I Y+S L K + S + V +N ++G IV
Sbjct: 223 TLCLGIGCIVTYSSALDKKTNFIKSSVYIVLINLLISFIMG-------------LIVFTF 269
Query: 313 VLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMY 372
+ G++ Q G+G + SL ++F Q+G G F +FL L+FAG TSA++M
Sbjct: 270 IFEFGADPHTQ------GVGIVFISLMSLFNQLGALGYIFAFCFFLALFFAGITSAVSMI 323
Query: 373 NYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALFDII 432
LT + + ISR +++ + F+ GI + ++ L+ + F L D +
Sbjct: 324 EPLTFYMINNYQISRVKALFLIGLFVFVFGICCI-LSLNLNFFSMFSFFGKDFFTLLDKL 382
Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLF 476
+L + G +N + YK + I+ + LF
Sbjct: 383 TSNFLLPLGAIVCSIFVGFFMNKKQIYKIFSKFISRKIFLIWLF 426
>dbj|BAA24689.1| (AB010832) putative tryptophan tranporter; similar to
sodium-dependent neurotransmitter symporter familly
(SNF) [Symbiobacterium thermophilum]
Length = 500
Score = 131 bits (325), Expect = 3e-29
Identities = 129/489 (26%), Positives = 213/489 (43%), Gaps = 60/489 (12%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QRD+W ++ G I A G A+GLGNF RFP NGGGAF++PYF+AL G+P+M +E
Sbjct: 4 QRDQWKSRSGFIFATIGAAVGLGNFWRFPFMAYQNGGGAFLLPYFVALLTAGVPLMILE- 62
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+G G T + A + L R I G ++ ++Y +I WS
Sbjct: 63 --------FGFGHKMRTATITAFKKLNRRFEWI-----GWWQITVPVVVVTFYSVIISWS 109
Query: 130 AAYSWFSISGAYFNVESTAKFFES-YLSNHG----LVFLFWGITVVLLAI------AVGQ 178
Y FS + A+ + T FF S +L L L WGI + + Q
Sbjct: 110 LRYLIFSFTQAWGDDPGT--FFSSDFLGITSGPLELGGLRWGIFAAVAVVWFANYYISAQ 167
Query: 179 GVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEH 238
G+S GIE+ K+M P L V +I VI L G + +P+++ + +
Sbjct: 168 GISGGIEKACKIMTPFLIVAMLIFVIRGITLP--------GATYGLNYFLNPDFSKIMDP 219
Query: 239 LWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAV 298
V +AA Q+FF+ +L +G++ YASY+ P+ + L N + + G ++
Sbjct: 220 --GVWVAAYSQVFFSTTLAVGVMIAYASYV-PETRTWPTTLHYRLRNSSFDFMAGLAVFS 276
Query: 299 PLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQM---GTAGRFFGAL 355
L A VP E +A G G ++ + P + FG L
Sbjct: 277 TLGYAAVTAGVPFEEMAVA------------GPGVAFVAFPKAISMLPGPTWLQSLFGIL 324
Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING----Y 411
+F L AG +S+I+ + + + G+ RK +I F ++ G
Sbjct: 325 FFSALLLAGISSSISQMESFASAVIDRFGVDRKKLLGWFSLIGF--AFSALFATGAGVHI 382
Query: 412 LDQVDAWI-SFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIF 470
LD VD ++ S+ +A+L L + IV ++ + ++ + I V ++ + + P+
Sbjct: 383 LDIVDHFVGSYAIAILGLVEAIVLGYIMGTARIREHVNLTSDIRVGMWWDVLVKYVTPVL 442
Query: 471 IALPLFGTF 479
+ + F
Sbjct: 443 LGYNILSNF 451
>pir||H81407 probable sodium-dependent transmembrane transport protein Cj0601c
[imported] - Campylobacter jejuni (strain NCTC 11168)
>gi|6968068|emb|CAB75237.1| (AL139075) putative
sodium-dependent transmembrane transport protein
[Campylobacter jejuni]
Length = 447
Score = 130 bits (324), Expect = 4e-29
Identities = 133/488 (27%), Positives = 214/488 (43%), Gaps = 74/488 (15%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR W++ + IL +AG IG G RFP V NGGGA+++ + +A+ ++GIPV+ VE
Sbjct: 2 QRQTWSSTLTYILTVAGATIGFGATWRFPYLVGENGGGAYVLVFCIAMIIIGIPVILVEN 61
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
V GR K +S GL+G +F + +YY+ L GW
Sbjct: 62 VIGRKAMTNSVDAF----------KQKWQSIGYMGLLG---SFG----IMAYYMVLGGWV 104
Query: 130 AAYSW------FSISGAYFNVESTAKFFESYLSNHGL-VFLFWGITVVLLAIAVGQGVSK 182
Y W FS++ + E T +FF ++ + L V +F + V++ I + +G+
Sbjct: 105 LVYIWELTLGNFSLANV-VSKEFTHQFFNDKIAFNPLGVGIFTTVFVIINYIILKRGIID 163
Query: 183 GIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSV 242
GIE+ VK +MPLL++ +I+V L + ++ F I SP +
Sbjct: 164 GIEKSVKFLMPLLFICLIIVVGRNLTLDGAMAGVKFYLEPDFSKILSP----------KL 213
Query: 243 MLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAV 302
++ GQ+FF LSLG G++ +S+L +++A + + T LN V+ G I L
Sbjct: 214 LIDVLGQVFFALSLGFGVMITLSSHLNKNENMAKTAIYTGVLNTIIAVLAGFMIFPALFS 273
Query: 303 AYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWF 362
A LA S +L + E + FS+ G L+F+LL
Sbjct: 274 A---------GLAPDSGPSL--VFETLPIAFSHIHF----------GTIVCILFFVLLLI 312
Query: 363 AGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLG-IP----------VVYING- 410
A T+++ +Y + ++LEE S+ + F+LG +P +V I G
Sbjct: 313 AALTTSLPIYQVIISVLEEKFKYSKNLSINLTLGFIFILGNLPCILTYGPWRDIVIIKGK 372
Query: 411 -YLDQVDAWISFQL--ALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVI-- 465
D D +IS + L A F I W+ KEL + F W +
Sbjct: 373 NIFDSFD-FISGNILFVLTAFFCCIYVGWILGKQESLKELSNNNTLKSSWFGIWFYYVKY 431
Query: 466 IAPIFIAL 473
I P+ I +
Sbjct: 432 IVPLIILI 439
>gb|AAF73566.1| (AE002319) sodium-dependent transporter, putative [Chlamydia
muridarum]
Length = 490
Score = 123 bits (305), Expect = 6e-27
Identities = 121/472 (25%), Positives = 206/472 (43%), Gaps = 54/472 (11%)
Query: 14 WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
+++++G IL+M G AIG GN RFP VA NGGG+F++ + L L + IP++ VE G+
Sbjct: 8 FSSRLGFILSMMGVAIGAGNIWRFPRMVAQNGGGSFIILWLLFLLIWSIPLIIVELSLGK 67
Query: 74 YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
K GTL T P++A +GG + T +L YY +++GW +YS
Sbjct: 68 LTKKAPVGTLIRT--------AGPKAA----WLGGFVVLVATCIL-GYYSNIVGWGFSYS 114
Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWG---ITVVLLAIAVGQGVSKGIERWVKV 190
++++SG S F +NH ++ + + L + +G+ GIE K+
Sbjct: 115 FYALSGKI----SPGNNFPQLWANHCQSWMPLSCHCLALFLSYCVIRKGIVNGIESCNKI 170
Query: 191 MMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHL--WSVMLAASG 248
++PL + +++L+ +L + W I+ + + KE L + V + A
Sbjct: 171 LIPLFCICSLVLLARAVSLPN-----AWEGIRLL-------FVFNKESLSNYKVWIEALT 218
Query: 249 QIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKI 308
Q + G G++ YA + + + +G T N ++ + A + ++
Sbjct: 219 QNAWDTGAGWGLLLVYAGFTSKRTSLVTNGTITAVTNNLISFLMAVIVFSACASLDSTEM 278
Query: 309 VPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGF 365
+ L +G A+ N G+ F Y LP +F ++ A F A++FL A
Sbjct: 279 LG---LKEGVGAS------NIGMAFIY--LPELFTRLPQAHLLSTVFSAIFFLAFSMAAL 327
Query: 366 TSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLAL 425
+S I+M L+ L E GI + II FL+G+P + D D L L
Sbjct: 328 SSMISMLFLLSQTLTE-FGIKKHIAESSATIIAFLIGVPSALSLKFFDNQDTVWGIALIL 386
Query: 426 LALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFG 477
+ I + P L + + +VP YK + LPL G
Sbjct: 387 NGMIFIYAAISYGIP-----SLRKEVINSVPGDYKLKAYFDVLVKFLLPLEG 433
>gb|AAC46377.1| (AF017105) sodium-dependent transporter [Chlamydophila caviae]
Length = 386
Score = 121 bits (300), Expect = 2e-26
Identities = 103/396 (26%), Positives = 189/396 (47%), Gaps = 43/396 (10%)
Query: 14 WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
+++++G I +M G A+G GN RFP A NG GAF++ + L LF+ IP++ +E G+
Sbjct: 8 FSSRLGFIFSMMGIAVGAGNIWRFPRIAAQNGNGAFILIWLLFLFIWSIPLIIIELSLGK 67
Query: 74 YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
GTL T P+ A +GG + TT +L +YY +++GW +Y
Sbjct: 68 LTKNAPIGTLIKT--------AGPKRA----WLGGFVTLVTTCIL-AYYSNIVGWGLSYF 114
Query: 134 WFSISGAYFNVESTAKFFES-YLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMM 192
++SISG + + + +E+ Y S+ L+F F +++ L + + +G+ +GIE+ K+++
Sbjct: 115 YYSISGKIYAGNNFCQLWEAHYQSSFPLLFHF--LSLFLAYMIIRKGIVQGIEKCNKILI 172
Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEH-LWSVMLAASGQIF 251
P V ++L++ L + ++G + +++ ++ L + LW + A Q
Sbjct: 173 PSFCVCTLVLLVRAVTLP--------NAMQGIKQLFTFDFASLSSYKLW---IEALTQNA 221
Query: 252 FTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPP 311
+ G G++ Y+ + K V +G T N +++G + A
Sbjct: 222 WDTGAGWGLLLVYSGFASKKTGVVSNGALTAISNNXVSLIMGIIVFATCA---------- 271
Query: 312 EVLAKGSNAALQWISENFGLGFSYTSLPNIFVQM-GTA--GRFFGALWFLLLWFAGFTSA 368
L N + F S+ LP +F ++ G+A F +++FL A +S
Sbjct: 272 -SLDVXRNNTVTTRCGFFKHRHSFYYLPELFTRVPGSAYLPAIFSSIFFLAFAMAALSSM 330
Query: 369 IAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP 404
I+M L+ L E GI + + II F+LG+P
Sbjct: 331 ISMLFLLSQTLSE-FGIKKHVAEYSATIIAFILGVP 365
>pir||C71541 probable na-dependent transporter - Chlamydia trachomatis
(serotype D, strain UW3/Cx) >gi|3328640|gb|AAC67823.1|
(AE001296) Sodium-dependent amino acid transporter
[Chlamydia trachomatis]
Length = 490
Score = 121 bits (300), Expect = 2e-26
Identities = 120/471 (25%), Positives = 208/471 (43%), Gaps = 52/471 (11%)
Query: 14 WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
+++++G IL+M G AIG GN RFP VA NGGG F++ + L L + IP++ VE G+
Sbjct: 8 FSSRLGFILSMMGVAIGAGNIWRFPRMVAQNGGGTFILLWLLFLIIWSIPLIIVELSIGK 67
Query: 74 YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
K G L T P+SA +GG + T +L YY +++GW +Y
Sbjct: 68 LTRKAPIGALIRT--------AGPKSA----WLGGFIVLVATCIL-GYYSNIVGWGFSYF 114
Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIA---VGQGVSKGIERWVKV 190
++S+SG F ++H ++ + L +A + +G+ GIE K+
Sbjct: 115 FYSLSGKIV----PGNHFPQLWAHHCQSWMPLSCHCLALFLAYCIIRKGIVNGIETCNKI 170
Query: 191 MMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQI 250
++P ++ A++L+ +L W +G ++ N L + + V + A Q
Sbjct: 171 LIPFFFICALVLLARAVSL-----PHAW---EGIRLLFVFNKASLCD--YKVWIEALTQN 220
Query: 251 FFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVP 310
+ G G++ YA + + + +G T N F ++ + A + +++
Sbjct: 221 AWDTGAGWGLLLVYAGFASKQTSLVTNGAITAITNNFISFLMAVIVFSACASLDSTEMLG 280
Query: 311 PEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGFTS 367
L +G A+ N G+ F Y LP +F ++ A FF A++FL A +S
Sbjct: 281 ---LREGVGAS------NIGMAFIY--LPELFTRLPHAHILSTFFSAIFFLAFSMAALSS 329
Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
I+M L+ L E GI + I FL+G+P + D D L L
Sbjct: 330 MISMLFLLSQTLTE-FGIKKHIAESSATIAAFLIGVPSALNLQFFDNQDIVWGIALILNG 388
Query: 428 LFDIIVGVWLFKPDNFW-KELHEGALINVPEFYKWITVIIAPIFIALPLFG 477
+ ++++ ++ K L + + +VP YK T + LPL G
Sbjct: 389 M------IFIYSALSYGIKRLRQDVINSVPGDYKLKTYFDILVKFLLPLEG 433
>pir||F72095 na-dependent transporter - Chlamydophila pneumoniae (strain CWL029)
>gi|4376565|gb|AAD18439.1| (AE001614) Na-dependent
Transporter [Chlamydophila pneumoniae CWL029]
Length = 494
Score = 120 bits (298), Expect = 4e-26
Identities = 99/395 (25%), Positives = 181/395 (45%), Gaps = 41/395 (10%)
Query: 14 WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
+++++G I +M G A+G GN RFP A NGGGAF++ + LFL IP++ +E G+
Sbjct: 8 FSSRLGFIFSMIGIAVGAGNIWRFPRVAAQNGGGAFLILWLCFLFLWSIPLIIIELSIGK 67
Query: 74 YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
K G L T + F GG + TT +L +YY ++GW +Y
Sbjct: 68 LTKKAPIGALIKT------------AGKKFAWAGGFITLVTTCIL-AYYSTIVGWGLSYF 114
Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLA-IAVGQGVSKGIERWVKVMM 192
++++SG AK + S+ + + L+ +T + LA + + +G+ GIE+ K+++
Sbjct: 115 YYAVSGKIHLGNDFAKLWTSHYQSS--IPLWAHLTSLGLAYLVIRKGIVHGIEKCNKILI 172
Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFF 252
P ++ + L++ L ++G + ++S + + + V + A Q +
Sbjct: 173 PAFFLCTIALLLRAVTLP--------GAVQGIKQLFSCDKSCFSN--YKVWIEALTQNAW 222
Query: 253 TLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPE 312
G G++ YA + K V +G T N +++G + + + I+
Sbjct: 223 DTGAGWGLLLVYAGFASKKTGVVSNGALTAICNNLVSLIMG---IIIFSTCASLDILGTT 279
Query: 313 VLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGFTSAI 369
L G+ A+ +G ++ LP +F ++ F +++FL A +S I
Sbjct: 280 QLQDGAGAS--------SIGITFIYLPELFTRLPGGIYLTTLFSSIFFLAFSMAALSSMI 331
Query: 370 AMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP 404
+M L+ L E GI + II F+LGIP
Sbjct: 332 SMLFLLSQTLAE-FGIKPYISETLATIIAFVLGIP 365
>gb|AAF73672.1| (AE002208) sodium-dependent transporter, putative [Chlamydophila
pneumoniae AR39] >gi|8978664|dbj|BAA98500.1| (AP002546)
Na-dependent transporter [Chlamydophila pneumoniae J138]
Length = 494
Score = 120 bits (298), Expect = 4e-26
Identities = 99/395 (25%), Positives = 181/395 (45%), Gaps = 41/395 (10%)
Query: 14 WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
+++++G I +M G A+G GN RFP A NGGGAF++ + LFL IP++ +E G+
Sbjct: 8 FSSRLGFIFSMIGIAVGAGNIWRFPRVAAQNGGGAFLILWLCFLFLWSIPLIIIELSIGK 67
Query: 74 YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
K G L T + F GG + TT +L +YY ++GW +Y
Sbjct: 68 LTKKAPIGALIKT------------AGKKFAWAGGFITLVTTCIL-AYYSTIVGWGLSYF 114
Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLA-IAVGQGVSKGIERWVKVMM 192
++++SG AK + S+ + + L+ +T + LA + + +G+ GIE+ K+++
Sbjct: 115 YYAVSGKIHLGNDFAKLWTSHYQSS--IPLWAHLTSLGLAYLVIRKGIVHGIEKCNKILI 172
Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFF 252
P ++ + L++ L ++G + ++S + + + V + A Q +
Sbjct: 173 PAFFLCTIALLLRAVTLP--------GAVQGIKQLFSCDKSCFSN--YKVWIEALTQNAW 222
Query: 253 TLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPE 312
G G++ YA + K V +G T N +++G + + + I+
Sbjct: 223 DTGAGWGLLLVYAGFASKKTGVVSNGALTAICNNLVSLIMG---IIIFSTCASLDILGTT 279
Query: 313 VLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGFTSAI 369
L G+ A+ +G ++ LP +F ++ F +++FL A +S I
Sbjct: 280 QLQDGAGAS--------SIGITFIYLPELFTRLPGGIYLTTLFSSIFFLAFSMAALSSMI 331
Query: 370 AMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP 404
+M L+ L E GI + II F+LGIP
Sbjct: 332 SMLFLLSQTLAE-FGIKPYISETLATIIAFVLGIP 365
>dbj|BAA89537.1| (AB006986) taurine transporter [Cyprinus carpio]
Length = 625
Score = 119 bits (295), Expect = 9e-26
Identities = 131/509 (25%), Positives = 223/509 (43%), Gaps = 85/509 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KWA+K+ +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G++ + G + E L P IF IG A + +LLN YY+ ++ W
Sbjct: 100 ALGQFTSEGG---------ITCWEKLCP----IFTGIGYA-SIVIVSLLNIYYIVILAWG 145
Query: 130 AAY---------------------------------SWFSISGAYFNVESTAKFFESYLS 156
Y W +++ F T + + LS
Sbjct: 146 LYYLFQCFQPELPWASCNNKWNTENCIEDTLRKNKTLWGAVNATNFTSPVTEFWERNVLS 205
Query: 157 -NHGLV---FLFWGITVVLLAIAV--GQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
+ G+ + W + + LLA+ V + KG++ KV+ + + F +++V+ V +
Sbjct: 206 ISDGIEDVGHVKWDLALCLLAVWVICFFCIWKGVKSTGKVVYVTATFPFVMLIVLLVRGV 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F PN T L + V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAAEGIKFYLYPNLTRLGDP--EVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + L LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNCYRDCLLLGGLNSATSFVSGFAIFSVLG-----------FMAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLE-----EDL 383
G G ++ + P V M F+ L+F++L G S + + +T+L++
Sbjct: 366 GPGLAFIAYPKA-VSMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 384 GISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
G R+ IV + +LLG+ +V G Y+ Q+ D + + + LL A F+ I W++
Sbjct: 425 GYRREIFIAIVCFLSYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
DNF+ + E + KW +I P
Sbjct: 485 ADNFYDAIEEMIGYRPNPWMKWSWTVITP 513
>pir||A64582 sodium- and chloride-dependent transporter - Helicobacter pylori
(strain 26695) >gi|2313607|gb|AAD07562.1| (AE000564)
sodium- and chloride-dependent transporter [Helicobacter
pylori 26695]
Length = 442
Score = 117 bits (290), Expect = 4e-25
Identities = 103/392 (26%), Positives = 173/392 (43%), Gaps = 42/392 (10%)
Query: 16 TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
+K+G +LA G+AIGLG+ RFP +GGGAF++ + +G + E + G+
Sbjct: 6 SKLGFVLAALGSAIGLGHIWRFPYMTGVSGGGAFVLLFLFLSLSVGAAMFIAEMLLGQ-- 63
Query: 76 GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
T + P+ + L + L+ ++Y ++GW Y
Sbjct: 64 -----STQKNVTEAFKELDINPKKRWKYA----GLLLVSGPLILTFYGTILGWVLYYLVS 114
Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLL 195
N++ + + F L + GL + +++ V +G+ +GIE+ V+MPLL
Sbjct: 115 VSFNLPNNIQESEQIFTQTLQSIGLQSIGLFSVLLITGWIVSRGIKEGIEKLNLVLMPLL 174
Query: 196 YVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLS 255
+ L+ Y ++ S +S F F + P K+ V + GQ+FF+LS
Sbjct: 175 FATFFGLLFYAMSMDS------FSKAFHFMFDFKP-----KDLTSQVFTYSLGQVFFSLS 223
Query: 256 LGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLA 315
+G+GI YA+ ++ S + VVL G I + L A ++ V
Sbjct: 224 IGLGINITYAAVTDKTQNLLKSTIW---------VVLSG-ILISLV---AGLMIFTFVFE 270
Query: 316 KGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL 375
G+N + G G +TSLP +F QMG G L+ L L FAG TS +A+
Sbjct: 271 YGANVSQ-------GTGLIFTSLPVVFGQMGAIGILVSILFLLALAFAGITSTVALLEPS 323
Query: 376 TALLEEDLGISRKTGTWIVFIIYFLLGIPVVY 407
L E SR TW + + F++G+ +++
Sbjct: 324 VMYLTERYQYSRFKVTWGLVALIFVVGVVLIF 355
>dbj|BAB18038.1| (AB033497) taurine transporter [Tilapia mossambica]
Length = 629
Score = 114 bits (282), Expect = 3e-24
Identities = 129/510 (25%), Positives = 221/510 (43%), Gaps = 85/510 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KWA+K+ +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 44 QREKWASKLDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 103
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + G + L P IF IG A + +LLN YY+ ++ W
Sbjct: 104 ALGQYTSEGG---------ITCWAKLCP----IFTGIGYA-SIVIVSLLNIYYIVILAWG 149
Query: 130 AAY---------------------------------SWFSISGAYFNVESTAKFFESYLS 156
Y W + + F T + + LS
Sbjct: 150 LYYLFQCFQPELPWAKCKQPWNTEHCVEDTVRKNKTLWLAANATNFTSPVTEFWERNVLS 209
Query: 157 ----NHGLVFLFWGITVVLLAIAV--GQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
+ L W + + LLA+ V + KG++ KV+ + + F +++V+ V +
Sbjct: 210 ISTGIEDIGPLKWDLALCLLAVWVICFFCIWKGVKSTGKVVYITATFPFVMLIVLLVRGV 269
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F PN T L++ V + A QIFF+ ++ +G + + SY
Sbjct: 270 TLP------GAREGIKFYLYPNVTRLQDP--EVWIDAGTQIFFSYAICLGAMTSLGSYNK 321
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + L LN V G +I L +A+ + ++E+
Sbjct: 322 YKYNCYRDCLLLGGLNSGTSFVSGFAIFSVLG-----------FMAQEQGVDIADVAES- 369
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M + L+F++L G S + + +T++++ + RK
Sbjct: 370 GPGLAFIAYPKA-VSMMPLPTLWAILFFIMLLLLGLDSQFVEVEGQITSIVDLYPAVLRK 428
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI + +LLG+ +V G Y+ Q+ D + + + LL A F+ I W++
Sbjct: 429 GYRREIFIAVMCFMSYLLGLAMVTKGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYG 488
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
DNF+ + + + KW II P+
Sbjct: 489 VDNFYDAVEDMIGYRPNPWMKWSWSIITPV 518
>gi|6678223 taurine/beta-alanine transporter [Mus musculus]
>gi|6019476|gb|AAB70922.2| (AF020194) retinal taurine
transporter [Mus musculus]
Length = 621
Score = 114 bits (282), Expect = 3e-24
Identities = 128/509 (25%), Positives = 220/509 (43%), Gaps = 85/509 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNVYYIVILAWA 145
Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
Y W S+S A F E
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205
Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
S + N G + + ++L+ + + KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F P+ + L + V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN VLG +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVLGFAIFSILG-----------FMAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI I +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
DN + + + + K+ +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513
>pir||F71930 probable transporter - Helicobacter pylori (strain J99)
>gi|4154985|gb|AAD06027.1| (AE001479) putative
transporter [Helicobacter pylori J99]
Length = 442
Score = 114 bits (282), Expect = 3e-24
Identities = 101/392 (25%), Positives = 172/392 (43%), Gaps = 42/392 (10%)
Query: 16 TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
+K+G +LA G+AIGLG+ RFP +GGGAF++ + +G + E + G+
Sbjct: 6 SKLGFVLAALGSAIGLGHIWRFPYMTGVSGGGAFVLLFLFLSLSVGAAMFIAEMLLGQ-- 63
Query: 76 GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
T + P+ + + + L+ ++Y ++GW Y
Sbjct: 64 -----STQKNVTEAFKELDINPKKRWKYA----GIMLISGPLILTFYGTILGWVLYYLVS 114
Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLL 195
+++ + + F L + GL + + + V +G+ +GIE+ V+MPLL
Sbjct: 115 ISFNLPSSIQESEQIFTQTLQSIGLQSIGLFSVLFITGWIVSRGIKEGIEKLNLVLMPLL 174
Query: 196 YVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLS 255
+ L+ Y ++ S +S F F + P K+ V + GQ+FF+LS
Sbjct: 175 FATFFGLLFYAMSMDS------FSKAFHFMFDFKP-----KDLTSQVFTYSLGQVFFSLS 223
Query: 256 LGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLA 315
+G+GI YA+ ++ S + VVL G I + L A ++ V
Sbjct: 224 IGLGINITYAAVTDKTQNLLKSTIW---------VVLSG-ILISLV---AGLMIFTFVFE 270
Query: 316 KGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL 375
G+N + G G +TSLP +F QMG G L+ L L FAG TS +A+
Sbjct: 271 YGANVSQ-------GTGLIFTSLPVVFGQMGAIGVLVSILFLLALAFAGITSTVALLEPS 323
Query: 376 TALLEEDLGISRKTGTWIVFIIYFLLGIPVVY 407
L E SR TW + + F++G+ +++
Sbjct: 324 VMYLTEKYQYSRFKVTWGLVALIFVVGVVLIF 355
>gi|8394318 taurine/beta-alanine transporter [Rattus norvegicus]
>gi|400635|sp|P31643|NTTA_RAT SODIUM- AND
CHLORIDE-DEPENDENT TAURINE TRANSPORTER
>gi|2119582|pir||I57939 taurine transporter - rat
>gi|207542|gb|AAA42304.1| (M96601) taurine transporter
[Rattus norvegicus]
Length = 621
Score = 113 bits (281), Expect = 4e-24
Identities = 127/509 (24%), Positives = 220/509 (42%), Gaps = 85/509 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNVYYIVILAWA 145
Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
Y W S+S A F E
Sbjct: 146 TYYLFQSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSAANFTSPVIEFWERNVLS 205
Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
S + + G + + ++L+ + + KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F PN + L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGEGIKFYLYPNISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI I +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAIVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
DN + + + + K+ +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513
>sp|O35316|NTTA_MOUSE SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND BETA-ALANINE TRANSPORTER
Length = 621
Score = 113 bits (279), Expect = 7e-24
Identities = 128/510 (25%), Positives = 217/510 (42%), Gaps = 87/510 (17%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNVYYIVILAWA 145
Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
Y W S+S A F E
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205
Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
S + N G + + ++L+ + + KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F P+ + L + V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN VLG +I L + V I+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVLGFAIFSILGFMAQEQGVD--------------IAAES 363
Query: 330 GLGFSYTSLPN-IFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISR 387
G G ++ + P + V M F+ L+F++L G S + + +T+L++ R
Sbjct: 364 GPGLAFIAYPKAVDVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLR 423
Query: 388 KTGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLF 438
K +FI I +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 424 KGYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIY 483
Query: 439 KPDNFWKELHEGALINVPEFYKWITVIIAP 468
DN + + + + K+ +I P
Sbjct: 484 GGDNLYDGIEDMIGYRPGPWMKYSWAVITP 513
>gb|AAF76147.1|AF260239_1 (AF260239) taurine transporter [Bos taurus]
Length = 620
Score = 111 bits (276), Expect = 2e-23
Identities = 127/510 (24%), Positives = 221/510 (42%), Gaps = 85/510 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KWA++I +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWASRIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFAGIGYA-SIVIVSLLNIYYIIILAWA 145
Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
Y W S S A F T + LS
Sbjct: 146 MYYLFQSFQSELPWAKCNHSWNTPHCLEDTLRRNRSLWISNSTANFTSPVTEFWERKVLS 205
Query: 157 NHGLV----FLFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
+ L W + + LL + + KG++ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDEPGALKWDLALCLLLVWLVCFFCIWKGVKSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P G +F P+ + L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGAGIKFYLYPDISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ + RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLHPSLLRK 424
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI + +LLG+ +V G Y+ Q+ D + + + LL A F+ W++
Sbjct: 425 GFHREIFIASICCVTYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFAIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
DNF+ + + + K+ ++ P+
Sbjct: 485 SDNFYDGIEDMIGYRPGPWMKYCWAVVTPL 514
>gb|AAF57986.1| (AE003806) DAT gene product [Drosophila melanogaster]
Length = 576
Score = 111 bits (276), Expect = 2e-23
Identities = 130/538 (24%), Positives = 233/538 (43%), Gaps = 83/538 (15%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
++R+ W+ K+ +L++ G A+ L N RFP NGGGAF+VPY + L + GIP+ ++E
Sbjct: 25 DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYME 84
Query: 69 WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
G++ K G R +F IG A+ ++ YY +I W
Sbjct: 85 LALGQHNRKGAITCWG-------------RLVPLFKGIGYAVVL-IAFYVDFYYNVIIAW 130
Query: 129 SAAYSWFSISGA--------YFNVESTAKFFESYLSN-------HGLVFLFWGITVVLLA 173
S + + S + + +N + Y+ H L + W + + LL
Sbjct: 131 SLRFFFASFTNSLPWTSCNNIWNTPNCRPVTSRYILELNRSEGIHDLGAIKWDMALCLLI 190
Query: 174 IAVGQGVS--KGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSP 230
+ + S KGI KV+ L+ +AV+L++ + L P + G ++ +P
Sbjct: 191 VYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLP------GSFLGIQYYLTP 244
Query: 231 NWTYL-KEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAE 289
N++ + K +W + A+ Q+FF+L G G++ YASY ++V L T +N
Sbjct: 245 NFSAIYKAEVW---VDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATS 301
Query: 290 VVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA 348
+ G I L +A+ + +V +G G + P M A
Sbjct: 302 FIAGFVIFSVLGYMAHTLGVRIEDVATEGP-------------GLVFVVYPAAIATM-PA 347
Query: 349 GRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEEDLGISRKTGTWI--VFIIYFLLGIPV 405
F+ ++F++L G S+ +TAL +E I R ++ +F +YF++G+
Sbjct: 348 STFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLAS 407
Query: 406 VYINGY-----LDQVDAWISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYK 460
G+ LD+ A S +A+ F+ I W++ + F +++ + +I P
Sbjct: 408 CTQGGFYFFHLLDRYAAGYSILVAV--FFEAIAVSWIYGTNRFSEDIRD--MIGFPPGRY 463
Query: 461 WITV--IIAPIFIA-LPLFG-------TFTDLV----SKTLGWPAKIAIIAMLIIGAI 504
W +APIF+ + ++G T+ D V + LGW + + M+ AI
Sbjct: 464 WQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAI 521
>pir||S46487 taurine transporter - human >gi|559853|gb|AAA50842.1| (U16120)
placental taurine transporter [Homo sapiens]
Length = 620
Score = 110 bits (273), Expect = 3e-23
Identities = 128/510 (25%), Positives = 223/510 (43%), Gaps = 85/510 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145
Query: 130 AAYSWFS----ISGAYFNVE-STAKFFESYLSNHGLVFL-------------FWGITVVL 171
Y + S + A+ N +T E + + V++ FW V+
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205
Query: 172 LAIAVGQGVS---------------------KGIERWVKVM-MPLLYVFAVILVIYVFAL 209
L+ + S KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P G +F P+ T L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGAGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI + +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
DN + + + + K+ +I P+
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITPV 514
>gi|11433499 solute carrier family 6 (neurotransmitter transporter, taurine),
member 6 [Homo sapiens]
Length = 619
Score = 110 bits (273), Expect = 3e-23
Identities = 132/511 (25%), Positives = 223/511 (42%), Gaps = 87/511 (17%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145
Query: 130 AAYSWFS----ISGAYFNVE-STAKFFESYLSNHGLVFL-------------FWGITVVL 171
Y + S + A+ N +T E + + V++ FW V+
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205
Query: 172 LAIAVGQGVS---------------------KGIERWVKVM-MPLLYVFAVILVIYVFAL 209
L+ + S KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P G +F P+ T L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGAGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI I +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHE--GALINVPEFYKWITVIIAP 468
DN + + + G Y W T I+P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWATAPISP 515
>sp|P31641|NTTA_HUMAN SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER
>gi|7441660|pir||G01426 taurine transporter - human
>gi|799339|gb|AAC50443.1| (U09220) taurine transporter
[Homo sapiens]
Length = 620
Score = 110 bits (273), Expect = 3e-23
Identities = 128/510 (25%), Positives = 223/510 (43%), Gaps = 85/510 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145
Query: 130 AAYSWFS----ISGAYFNVE-STAKFFESYLSNHGLVFL-------------FWGITVVL 171
Y + S + A+ N +T E + + V++ FW V+
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205
Query: 172 LAIAVGQGVS---------------------KGIERWVKVM-MPLLYVFAVILVIYVFAL 209
L+ + S KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P G +F P+ T L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGAGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI + +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
DN + + + + K+ +I P+
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITPV 514
>gi|4507045 solute carrier family 6 (neurotransmitter transporter, taurine),
member 6; Solute carrier family 6 (neurotransmitter
transporter, taurine), [Homo sapiens]
>gi|346388|pir||S29839 taurine transport protein - human
>gi|36727|emb|CAA79481.1| (Z18956) taurine transporter
[Homo sapiens] >gi|266092|gb|AAB25509.1| taurine
transporter, HTAU [human, thyroid cells, Peptide, 619
aa]
Length = 619
Score = 110 bits (272), Expect = 5e-23
Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 85/490 (17%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145
Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
Y W +IS F + + LS
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205
Query: 157 -NHGLVF---LFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
+ G+ L W + + LL + + KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCICKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F P+ T L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGRGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI I +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHE 449
DN + + +
Sbjct: 485 GDNLYDGIED 494
>sp|P31652|NTSE_RAT SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
>gi|478853|pir||S30604 neurotransmitter transport
protein - rat >gi|56780|emb|CAA45401.1| (X63995)
neurotransmitter transporter [Rattus norvegicus]
>gi|57743|emb|CAA44913.1| (X63253) serotonin transporter
[Rattus rattus] >gi|1841938|emb|CAA71909.1| (Y11024)
serotonin transporter [Rattus norvegicus]
>gi|228364|prf||1803245A neurotransmitter transporter
NTT [Rattus norvegicus]
Length = 630
Score = 109 bits (271), Expect = 6e-23
Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
I+ +R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+
Sbjct: 74 IRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
++E G+Y + +G + S+ + IF IG A+ + SYY +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179
Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
I W+ Y SW F+ + + ST+ E YL +
Sbjct: 180 IAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239
Query: 158 ------HGLVFLFWGIT--VVLLAIAVGQGVSKGIER-----WVKVMMPLLYVFAVILVI 204
L + W +T +VL+ + + KG++ WV P + V +V+LV
Sbjct: 240 HQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298
Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
G+ W +G F PNW L E V + A+ QIFF+L G G++ +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347
Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
ASY ++ L T +N V G I L +A+ N +
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 396
Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
++++ G + + M A FF ++FL+L G S A + +TA+L+E
Sbjct: 397 VAKDAGPSLLFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455
Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
I K W V I+ +LG + +G V + + +AL + + W
Sbjct: 456 HIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWF 515
Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
+ F ++ E + F++ V I+P+F+
Sbjct: 516 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 549
>pir||S19585 serotonin transport protein - rat >gi|228225|prf||1718346A
serotonin transporter [Rattus rattus]
Length = 607
Score = 109 bits (271), Expect = 6e-23
Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
I+ +R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+
Sbjct: 51 IRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 110
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
++E G+Y + +G + S+ + IF IG A+ + SYY +
Sbjct: 111 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 156
Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
I W+ Y SW F+ + + ST+ E YL +
Sbjct: 157 IAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 216
Query: 158 ------HGLVFLFWGIT--VVLLAIAVGQGVSKGIER-----WVKVMMPLLYVFAVILVI 204
L + W +T +VL+ + + KG++ WV P + V +V+LV
Sbjct: 217 HQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 275
Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
G+ W +G F PNW L E V + A+ QIFF+L G G++ +
Sbjct: 276 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 324
Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
ASY ++ L T +N V G I L +A+ N +
Sbjct: 325 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 373
Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
++++ G + + M A FF ++FL+L G S A + +TA+L+E
Sbjct: 374 VAKDAGPSLLFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 432
Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
I K W V I+ +LG + +G V + + +AL + + W
Sbjct: 433 HIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWF 492
Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
+ F ++ E + F++ V I+P+F+
Sbjct: 493 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 526
>pir||A47194 taurine and beta-alanine transporter, TAUT - mouse
Length = 590
Score = 109 bits (270), Expect = 8e-23
Identities = 126/509 (24%), Positives = 218/509 (42%), Gaps = 85/509 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F I A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIAYA-SIVIVSLLNVYYIVILAWA 145
Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
Y W S+S A F E
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205
Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
S + N G + + ++L+ + + KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F P+ + L + V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI I +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
DN + + + + K+ +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513
>sp|P31642|NTTA_MUSCO SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND BETA-ALANINE TRANSPORTER
>gi|2078449|gb|AAB54039.1| (L03292) taurine/beta-alanine
transporter [Mus cookii]
Length = 621
Score = 109 bits (270), Expect = 8e-23
Identities = 126/509 (24%), Positives = 218/509 (42%), Gaps = 85/509 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F I A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIAYA-SIVIVSLLNVYYIVILAWA 145
Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
Y W S+S A F E
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205
Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
S + N G + + ++L+ + + KG+ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P +G +F P+ + L + V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424
Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI I +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
DN + + + + K+ +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513
>sp|Q00589|NTTA_CANFA SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER
>gi|290092|gb|AAA30876.1| (M95495) Na/Cl-dependent
taurine transporter [Canis familiaris]
Length = 620
Score = 109 bits (269), Expect = 1e-22
Identities = 125/510 (24%), Positives = 221/510 (42%), Gaps = 85/510 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNIYYVIILAWA 145
Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
Y W ++S F T + + LS
Sbjct: 146 TYYLFQSFQSELPWAHCNHSWNTPQCMEDTMRKNKSLWITLSTKNFTSPVTEFWERNVLS 205
Query: 157 NHGLV----FLFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
+ L W + + LL + + KG++ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDDPGSLKWDLALCLLLVWLVCFFCIWKGVKSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P G +F P+ + L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGAGIKFYLYPDISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQVTSLVDLYPSFLRK 424
Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI + +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GFRREIFIAFMCSISYLLGLSMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
DN + + + + K+ ++ P+
Sbjct: 485 SDNLYDGIEDMIGYRPGPWMKYSWAVVTPV 514
>pir||A46270 Na and Cl dependent taurine transporter - dog
Length = 655
Score = 109 bits (269), Expect = 1e-22
Identities = 125/510 (24%), Positives = 221/510 (42%), Gaps = 85/510 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
QR+KW++KI +L++AG +GLGN RFP NGGGAF++PYF+ LF G+PV ++E
Sbjct: 40 QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
+ G+Y + G + E + P +F IG A + +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNIYYVIILAWA 145
Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
Y W ++S F T + + LS
Sbjct: 146 TYYLFQSFQSELPWAHCNHSWNTPQCMEDTMRKNKSLWITLSTKNFTSPVTEFWERNVLS 205
Query: 157 NHGLV----FLFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
+ L W + + LL + + KG++ KV+ + FA++LV+ V L
Sbjct: 206 LSSGIDDPGSLKWDLALCLLLVWLVCFFCIWKGVKSTGKVVYFTATFPFAMLLVLLVRGL 265
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
P G +F P+ + L++ V + A QIFF+ ++ +G + + SY
Sbjct: 266 TLP------GAGAGIKFYLYPDISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
K + + LN V G +I L +A+ + ++E+
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M F+ L+F++L G S + + +T+L++ RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQVTSLVDLYPSFLRK 424
Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
+FI + +LLG+ +V G Y+ Q+ D + + + LL A F+ V W++
Sbjct: 425 GFRREIFIAFMCSISYLLGLSMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484
Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
DN + + + + K+ ++ P+
Sbjct: 485 SDNLYDGIEDMIGYRPGPWMKYSWAVVTPV 514
>sp|Q60857|NTSE_MOUSE SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
>gi|2338560|gb|AAB67172.1| (AF013604) serotonin
transporter [Mus musculus]
Length = 630
Score = 108 bits (268), Expect = 1e-22
Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
I +R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+
Sbjct: 74 IHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
++E G+Y + +G + S+ + IF IG A+ + SYY +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179
Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
I W+ Y SW F+ + + ST+ E YL +
Sbjct: 180 IAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239
Query: 158 ------HGLVFLFWGITVVLLAI------AVGQGV-SKGIERWVKVMMPLLYVFAVILVI 204
L + W + + ++ I ++ +GV + G WV P + V +V+LV
Sbjct: 240 HQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298
Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
G+ W +G F PNW L E V + A+ QIFF+L G G++ +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347
Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
ASY ++ L T +N V G I L +A+ N +
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 396
Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
++++ G + + M A FF ++FL+L G S A + +TA+L+E
Sbjct: 397 VAKDAGPSLLFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455
Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
I K W V I+ +LG + +G V + + +AL + +V W
Sbjct: 456 HIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWF 515
Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
+ F ++ E + F++ V I+P+F+
Sbjct: 516 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 549
>gb|AAD26262.1|AF119122_1 (AF119122) serotonin transporter [Bos taurus]
Length = 630
Score = 108 bits (268), Expect = 1e-22
Identities = 125/511 (24%), Positives = 213/511 (41%), Gaps = 88/511 (17%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ WA K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+ ++E
Sbjct: 78 ERETWAKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + +G + S+ + IF IG A+ + SYY +I W+
Sbjct: 138 ALGQY---HRNGCI----------SIWTKICPIFKGIGCAICL-IAFYIASYYNTIIAWA 183
Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESYLSN-------- 157
Y SW FS + + ST+ E Y +
Sbjct: 184 LYYLISSFTEQLPWTSCENSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 243
Query: 158 --HGLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
L L W + + ++ I + + KG++ KV+ + F I+++ + G+ L
Sbjct: 244 GLQDLGGLSWQLVLCIMFIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILLILLVRGATL 302
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
W +G F PNW L E V + A+ QIFF+L G G++ +ASY ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNN 356
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
L T ++N V G I L + +AK + +L +I+
Sbjct: 357 CYQDALVTSAVNCMTSFVSGFVIFTVLGYMAEMRKEDVSEVAKDAGPSLLFIT----YAE 412
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISRKTGTW 392
+ ++P A FF ++FL+L G S A + +TA+L+E + K W
Sbjct: 413 AIANMP--------ASTFFAIVFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRREW 464
Query: 393 IVFIIYFLLGIPVVYINGYLDQVDAWISFQLALL------------ALFDIIVGVWLFKP 440
F+LG+ + G L + ++ + LL AL + + W +
Sbjct: 465 ------FVLGVVITCFFGSLVTLTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGI 518
Query: 441 DNFWKELHEGALINVPEFYKWITVIIAPIFI 471
+ F ++ E + F+K V I+P+F+
Sbjct: 519 NQFCSDVKEMLGFSPGWFWKICWVAISPLFL 549
>gi|8394200 GABA transporter [Rattus norvegicus] >gi|881598|gb|AAC52867.1|
(U28927) Na+/Cl- betaine/GABA transporter [Rattus
norvegicus]
Length = 628
Score = 108 bits (267), Expect = 2e-22
Identities = 124/490 (25%), Positives = 206/490 (41%), Gaps = 81/490 (16%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
Q++ R +W K+ +L++AG IGLGN RFP NGGGAF +PYF+ F GIPV +
Sbjct: 46 QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFF 105
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
+E G+Y + + A + P L+ G+ G + + LN YY+ ++
Sbjct: 106 LEVALGQYSSQGS---------VTAWRKICP---LLQGI--GMASVVIESYLNIYYIIIL 151
Query: 127 GWSAAYSWFSISGA-----------------YFNVEST--AKFFESYLSN---------- 157
W+ Y + S + + N ST A + E++ S
Sbjct: 152 AWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVL 211
Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFAL 209
H L L W + + LL I + KG++ KV+ F +++I +
Sbjct: 212 GITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY-FTATFPYLMLIILLIR 270
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
G L +G F P+ LK+ V + A QIFF+ ++ G + SY
Sbjct: 271 GVTLP----GAYQGIVFYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYNK 324
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
++ +A LN V G + L + VP +A+
Sbjct: 325 YHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAES------------ 372
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M + + L+FL+L F G S + M +TA ++ RK
Sbjct: 373 GPGLAFIAFPKA-VTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRK 431
Query: 389 TGT-----WIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
G V I+ +L+G+ +V G Y+ Q+ D + S + LL +LF++I W++
Sbjct: 432 RGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYG 491
Query: 440 PDNFWKELHE 449
D F+ + +
Sbjct: 492 ADRFYDNVED 501
>sp|P48056|NTBE_RAT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
(NA+/CL-BETAINE/GABA TRANSPORTER)
Length = 614
Score = 108 bits (267), Expect = 2e-22
Identities = 124/490 (25%), Positives = 206/490 (41%), Gaps = 81/490 (16%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
Q++ R +W K+ +L++AG IGLGN RFP NGGGAF +PYF+ F GIPV +
Sbjct: 32 QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFF 91
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
+E G+Y + + A + P L+ G+ G + + LN YY+ ++
Sbjct: 92 LEVALGQYSSQGS---------VTAWRKICP---LLQGI--GMASVVIESYLNIYYIIIL 137
Query: 127 GWSAAYSWFSISGA-----------------YFNVEST--AKFFESYLSN---------- 157
W+ Y + S + + N ST A + E++ S
Sbjct: 138 AWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVL 197
Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFAL 209
H L L W + + LL I + KG++ KV+ F +++I +
Sbjct: 198 GITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY-FTATFPYLMLIILLIR 256
Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
G L +G F P+ LK+ V + A QIFF+ ++ G + SY
Sbjct: 257 GVTLP----GAYQGIVFYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYNK 310
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
++ +A LN V G + L + VP +A+
Sbjct: 311 YHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAES------------ 358
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
G G ++ + P V M + + L+FL+L F G S + M +TA ++ RK
Sbjct: 359 GPGLAFIAFPKA-VTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRK 417
Query: 389 TGT-----WIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
G V I+ +L+G+ +V G Y+ Q+ D + S + LL +LF++I W++
Sbjct: 418 RGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYG 477
Query: 440 PDNFWKELHE 449
D F+ + +
Sbjct: 478 ADRFYDNVED 487
>gi|7110639 5-hydroxytryptamine (serotonin) transporter [Mus musculus]
>gi|1771316|emb|CAA70092.1| (Y08870) serotonin
transporter [Mus musculus]
Length = 630
Score = 107 bits (265), Expect = 3e-22
Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
I +R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+
Sbjct: 74 IHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
++E G+Y + +G + S+ + IF IG A+ + SYY +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179
Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
I W+ Y SW F+ + + ST+ E YL +
Sbjct: 180 IAWALYYLISSFTDQLQWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239
Query: 158 ------HGLVFLFWGITVVLLAI------AVGQGV-SKGIERWVKVMMPLLYVFAVILVI 204
L + W + + ++ I ++ +GV + G WV P + V +V+LV
Sbjct: 240 HQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298
Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
G+ W +G F PNW L E V + A+ QIFF+L G G++ +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347
Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
ASY ++ L T +N V G I L +A+ N +
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 396
Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
++++ G + + M A FF ++FL+L G S A + +TA+L+E
Sbjct: 397 VAKDAGPSLLFITYAEAIRNM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455
Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
I K W V I+ +LG + +G V + + +AL + +V W
Sbjct: 456 HIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWF 515
Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
+ F ++ E + F++ V I+P+F+
Sbjct: 516 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 549
>pir||S63539 GABA/beta-alanine transporter - marbled electric ray
>gi|1171630|emb|CAA60635.1| (X87170) GABA/beta-alanine
transporter [Torpedo marmorata]
Length = 622
Score = 106 bits (261), Expect = 9e-22
Identities = 141/582 (24%), Positives = 243/582 (41%), Gaps = 109/582 (18%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
+M +R W KI +L++AG IGLGN RFP NGGGAF++PY + GIPV +
Sbjct: 34 RMSERGHWNNKIEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVIFFIGCGIPVFF 93
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYL 123
+E G+Y + G + + P +F IG +AT + LN +Y+
Sbjct: 94 LETALGQYTSEGG---------ITCWRKICP----LFEGIG----YATQVIEAHLNMFYI 136
Query: 124 HLIGWSAAYSW--------FSISGAYFNVESTAKF--FESYLSNHGLV-------FLFWG 166
++ W+ Y + ++ G Y+N E+ +F S NH V FW
Sbjct: 137 IVLAWAIFYLFNCFTSELPWATCGHYWNTENCLEFQKLNSTNCNHTAVPNATSPVIEFWE 196
Query: 167 ITVVLLAIAVGQGVSKGIE-----RWVKVMMPLLYVFAVIL------------VIYVFAL 209
V+ G+S+GIE RW ++ + LL + + V+YV A
Sbjct: 197 RRVL--------GLSRGIEHIGRVRW-ELALCLLAAWIICYFCIWKGPKSTGKVVYVTAT 247
Query: 210 GSPL--------GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGII 261
L G +G +F P+ + L + V L A QIFF+ ++ +G +
Sbjct: 248 FPYLMLLVLLIRGVTLPGAAEGIKFYLYPDVSRLSDP--QVWLDAGTQIFFSYAICLGCL 305
Query: 262 QNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAA 321
SY ++ + LN V G +I L + VP +A+
Sbjct: 306 TALGSYNPYHNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAFEQGVPIAEVAES---- 361
Query: 322 LQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLE 380
G G ++ + P M A + L+FL+L F G S + M + +TA+++
Sbjct: 362 --------GPGLTFIAYPKAVTMMPLA-PLWAFLFFLMLIFLGLDSQFVCMESLVTAIID 412
Query: 381 E-----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDI 431
G R+ +++ + +L+G+ +V G Y+ Q+ DA+ S + LL A+F+
Sbjct: 413 MYPSIFRRGYRREQLIFVIALASYLMGLVMVTEGGMYIFQLFDAYASSGMCLLFVAIFEC 472
Query: 432 IVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP-IFIALPLFGTFTDLVSK----- 485
I W++ + F+ + + KW + I P I A+ +F K
Sbjct: 473 ICIGWVYGGNRFYDNIEDMIGYRPFVLIKWCWIFITPGICAAIFIFFIVRYQPLKYNNVY 532
Query: 486 -------TLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEK 520
LGW ++ + + +G I ++ + + E+++K
Sbjct: 533 VYPDWGYALGWALALSSMICIPLGFIFKMWSTEGTFLEKIKK 574
>sp|P31651|NTBE_MOUSE SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
(NA+/CL-BETAINE/GABA TRANSPORTER) (SODIUM- AND
CHLORIDE-DEPENDENT GABA TRANSPORTER 2) (GAT2)
>gi|346711|pir||A43390 gamma-aminobutyric acid
transporter protein GAT2 - mouse
Length = 614
Score = 105 bits (259), Expect = 2e-21
Identities = 122/494 (24%), Positives = 207/494 (41%), Gaps = 81/494 (16%)
Query: 3 RGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGI 62
+G Q++ R +W K+ +L++AG IGLGN RFP NGGGAF +PYF+ F GI
Sbjct: 28 KGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGI 87
Query: 63 PVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYY 122
PV ++E G+Y + + A + P L+ G+ G + + LN YY
Sbjct: 88 PVFFLEVALGQYSSQGS---------VTAWRKICP---LLQGI--GMASVVIESYLNIYY 133
Query: 123 LHLIGWSAAYSWFSISGAY--------FNVESTAKFF-----------ESYLSN------ 157
+ ++ W+ Y + S + +N E F E++ S
Sbjct: 134 IIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWE 193
Query: 158 ----------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVMMPLLYVFAVILVIY 205
H L L W + + LL I + KG++ KV+ F +++I
Sbjct: 194 RRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY-FTATFPYLMLII 252
Query: 206 VFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYA 265
+ G L +G F P+ LK+ V + A QIFF+ ++ G +
Sbjct: 253 LLIRGVTLP----GAYQGIVFYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALG 306
Query: 266 SYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWI 325
SY ++ +A LN V G + L + +P +A+
Sbjct: 307 SYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAES-------- 358
Query: 326 SENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLG 384
G G ++ + P V M + + L+F++L F G S + M +TA ++
Sbjct: 359 ----GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQ 413
Query: 385 ISRKTGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGV 435
RK+G V I+ +L+G+ +V G Y+ Q+ D + S + LL +LF++I
Sbjct: 414 QLRKSGRRDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIG 473
Query: 436 WLFKPDNFWKELHE 449
W++ D F+ + +
Sbjct: 474 WVYGADRFYDNVED 487
>gi|6981554 solute carrier family 6 (neurotransmitter transporter, serotonin),
member 4 (5-hydroxytryptamine (serotonin) transporter)
[Rattus norvegicus] >gi|207087|gb|AAA42186.1| (M79450)
serotonin transporter [Rattus norvegicus]
Length = 653
Score = 105 bits (259), Expect = 2e-21
Identities = 114/434 (26%), Positives = 182/434 (41%), Gaps = 80/434 (18%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
I+ +R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+
Sbjct: 74 IRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
++E G+Y + +G + S+ + IF IG A+ + SYY +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179
Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
I W+ Y SW F+ + + ST+ E YL +
Sbjct: 180 IAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239
Query: 158 ------HGLVFLFWGIT--VVLLAIAVGQGVSKGIER-----WVKVMMPLLYVFAVILVI 204
L + W +T +VL+ + + KG++ WV P + V +V+LV
Sbjct: 240 HQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298
Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
G+ W +G F PNW L E V + A+ QIFF+L G G++ +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347
Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
ASY ++ L T +N V G I L + +AK + +L +
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLF 407
Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
I+ +G ++P A FF ++FL+L G S A + +TA+L+E
Sbjct: 408 ITYAEAIG----NMP--------ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455
Query: 384 GISRKTGTWIVFII 397
I K W V I+
Sbjct: 456 HIWAKRREWFVLIV 469
>gb|AAC05185.1| (AF049108) GABA transporter [Raja sp.]
Length = 598
Score = 104 bits (258), Expect = 2e-21
Identities = 117/483 (24%), Positives = 197/483 (40%), Gaps = 82/483 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+KW K +L+ G AIGLGN RFP NGGGAF++PYFL L G+P+ +E
Sbjct: 42 EREKWGGKYEFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGMPIFLLEC 101
Query: 70 VQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
G+Y G G L P F + GL L+F LN YY+ +I
Sbjct: 102 SLGQYTSVGGLGIWRLAPMFKGV-------------GLAAAVLSF----WLNIYYVVIIA 144
Query: 128 WSAAY---------SWFSISGAYFNVESTAKFFESYLSNH-GLVFLFW------------ 165
W+ Y W S A+ ++ + S +N + FW
Sbjct: 145 WAIYYLYNSFTSELPWQSCGNAWNTERCSSNYSMSNTTNFTNPIVEFWERNMHQLSDGLD 204
Query: 166 ---------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQP 216
IT+ + + V + KG+ W ++ ++ I+++ +F G L
Sbjct: 205 QPGQIRAPLAITLAIAWVLVYFCIWKGVS-WTGKVVYFSAIYPYIMLLTLFFRGVTLPGA 263
Query: 217 QWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL 276
+ +G F +P+++ L + V L A+ QIFF+ LG+G + SY +++
Sbjct: 264 R----EGILFYITPDFSRLTDS--EVWLDAATQIFFSYGLGLGSLVALGSYNTFHNNIYR 317
Query: 277 SGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSY 335
+ +N + G I ++ +A+ +V A G G ++
Sbjct: 318 DSIIVCCINSTTSMFAGFVIFSIVGFMAHVTNRPIADVAASGP-------------GLAF 364
Query: 336 TSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKTGT 391
+ P Q+ F+ L+F +L G S + ++TAL++E L R+
Sbjct: 365 LAYPEAVTQL-PISPFWSILFFSMLLMLGIDSQFCTVEGFITALVDEFPKLLRGRREIFI 423
Query: 392 WIVFIIYFLLGIPVV-----YINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFWKE 446
+V II +L+G+ + Y+ D A L L F+ I W + + F+
Sbjct: 424 AVVCIISYLIGLSNITQGGLYVFKLFDYYSA-SGMSLLFLVFFETISISWCYGVNRFFGN 482
Query: 447 LHE 449
+ E
Sbjct: 483 IEE 485
>gb|AAF97247.1|AF285761_1 (AF285761) serotonin transporter [Macaca mulatta]
Length = 630
Score = 104 bits (258), Expect = 2e-21
Identities = 119/505 (23%), Positives = 210/505 (41%), Gaps = 76/505 (15%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+ ++E
Sbjct: 78 ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMEL 137
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + +G + S+ + IF IG A+ + SYY ++ W+
Sbjct: 138 ALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTIMAWA 183
Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESY----------- 154
Y SW FS + + ST+ E Y
Sbjct: 184 LYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 243
Query: 155 -LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
L + G + + ++L+ + + KG++ KV+ + F I++ + G+ L
Sbjct: 244 GLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILSVLLVRGATL 302
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
W +G F PNW L E V + A+ QIFF+L G G++ +ASY ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNN 356
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
L T +N V G I L +A+ N + ++++ G
Sbjct: 357 CYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSEVAKDAGPSL 405
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISRKTGTW 392
+ + M A FF ++FL+L G S A + +TA+L+E I K W
Sbjct: 406 LFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREW 464
Query: 393 IVFII----YFLLGIPVVYINGYLDQVDAWISFQLALL--ALFDIIVGVWLFKPDNFWKE 446
V + +F + + + Y+ ++ + A+L AL + + W + F ++
Sbjct: 465 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRD 524
Query: 447 LHEGALINVPEFYKWITVIIAPIFI 471
+ E + F++ V I+P+F+
Sbjct: 525 VKEMLGFSPGWFWRICWVAISPLFL 549
>gi|4507039 solute carrier family 6 (neurotransmitter transporter, GABA),
member 1 [Homo sapiens] >gi|266666|sp|P30531|NTG1_HUMAN
SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
>gi|106051|pir||S11073 gamma-aminobutyric acid transport
protein - human >gi|31658|emb|CAA38484.1| (X54673) GABA
transporter [Homo sapiens]
Length = 599
Score = 104 bits (257), Expect = 3e-21
Identities = 134/572 (23%), Positives = 227/572 (39%), Gaps = 93/572 (16%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ RD W + +++ G AIGLGN RFP NGGGAF++PYFL L G+P+ +
Sbjct: 41 LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100
Query: 68 EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
E G+Y G G L P F + GL L+F LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWKLAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143
Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
I W+ Y + S + N +T + F +Y + V FW
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDG 203
Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
IT+ + I V + KG+ W ++ + I++I +F G L
Sbjct: 204 LDKPGQIRWPLAITLAIAWILVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 262
Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
+ +G F +PN+ L + V L A+ QIFF+ LG+G + SY ++V
Sbjct: 263 GAK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNV 316
Query: 275 ALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
+ +N + G I ++ +A+ K +V A G G
Sbjct: 317 YRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GL 363
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKT 389
++ + P Q+ + L+F +L G S + ++TAL++E L R+
Sbjct: 364 AFLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRREL 422
Query: 390 GTWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFW 444
V II +L+G+ +Y+ D A L L F+ + W + + F+
Sbjct: 423 FIAAVCIISYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFY 481
Query: 445 KELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----A 494
+ E ++K PI +A + + T+G W + A
Sbjct: 482 DNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMA 541
Query: 495 IIAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
+ +M++I AY + K G ++ +V+++
Sbjct: 542 LSSMVLIPGYMAYMFLALK-GSLKQRIQVMVQ 572
>sp|O35899|NTSE_CAVPO SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
>gi|2584855|gb|AAB82737.1| (U84498) transmembrane 5-HT
transporter [Cavia porcellus]
Length = 630
Score = 104 bits (256), Expect = 3e-21
Identities = 123/510 (24%), Positives = 210/510 (41%), Gaps = 86/510 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+ ++E
Sbjct: 78 ERETWGKKVDFLLSVIGYAVDLGNIWRFPYVCYQNGGGAFLLPYIIMAIFGGIPLFYMEL 137
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + +G + S+ + IF IG + + SYY +I W+
Sbjct: 138 ALGQY---HRNGCI----------SIWRKICPIFKGIGYTICI-IAFYIASYYNTIIAWA 183
Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESYLSN-------- 157
Y SW FS + + ST+ E Y+ +
Sbjct: 184 LYYLISSFTDRLPWTSCRNSWNTANCTNYFSEDNITWTLHSTSPAEEFYIRHILQIHRSK 243
Query: 158 --HGLVFLFWGITVVLLAI------AVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFA 208
+ + W +T+ ++ I ++ +GV + G WV P + V +V+LV
Sbjct: 244 GLQDVGGVSWQLTLCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVRGATL 302
Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYL 268
G+ W KG F PNW L E V + A+ QIFF+L G G++ +ASY
Sbjct: 303 PGA------W---KGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYN 351
Query: 269 GPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISEN 328
++ L T ++N V G I L + +AK + +L +I+
Sbjct: 352 KFNNNCYQDALVTSAVNCMTSFVSGFVIFTVLGYMAEMRSEDVSEVAKDAGPSLLFIT-- 409
Query: 329 FGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISR 387
+ ++P A FF ++FL+L G S A + +TA+L+E I
Sbjct: 410 --YAEAIANMP--------ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWA 459
Query: 388 KTGTWIVF---IIYFLLGIPVVYING--YLDQVDAWISFQLALLALF-DIIVGVWLFKPD 441
K W V I F + + G + ++ + + L +F + I W +
Sbjct: 460 KHREWFVLAVVITCFFGSLTTLTFGGAYVVKLLEEYATGPAVLTVVFIEAIAVSWFYGVT 519
Query: 442 NFWKELHEGALINVPEFYKWITVIIAPIFI 471
F ++ E + F++ V ++P+F+
Sbjct: 520 QFCSDVKEMLGFSPGWFWRICWVAVSPVFL 549
>sp|P23978|NTG1_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
>gi|72010|pir||ACRTGT gamma-aminobutyric acid transport
protein - rat >gi|204222|gb|AAA63487.1| (M59742) GABA
transporter protein [Rattus norvegicus]
Length = 599
Score = 104 bits (256), Expect = 3e-21
Identities = 133/572 (23%), Positives = 227/572 (39%), Gaps = 93/572 (16%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ RD W + +++ G AIGLGN RFP NGGGAF++PYFL L G+P+ +
Sbjct: 41 LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100
Query: 68 EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
E G+Y G G L P F + GL L+F LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWKLAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143
Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
I W+ Y + S + N +T + F +Y + V FW
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDG 203
Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
IT+ + + V + KG+ W ++ + I++I +F G L
Sbjct: 204 LDKPGQIRWPLAITLAIAWVLVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 262
Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
+ +G F +PN+ L + V L A+ QIFF+ LG+G + SY ++V
Sbjct: 263 GAK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNV 316
Query: 275 ALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
+ +N + G I ++ +A+ K +V A G G
Sbjct: 317 YRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GL 363
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKT 389
++ + P Q+ + L+F +L G S + ++TAL++E L R+
Sbjct: 364 AFLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRREL 422
Query: 390 GTWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFW 444
V I+ +L+G+ +Y+ D A L L F+ + W + + F+
Sbjct: 423 FIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFY 481
Query: 445 KELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----A 494
+ E ++K PI +A + + T+G W + A
Sbjct: 482 DNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMA 541
Query: 495 IIAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
+ +M++I AY + K G ++ +V+I+
Sbjct: 542 LSSMVLIPGYMAYMFLTLK-GSLKQRLQVMIQ 572
>sp|P48057|NTG1_MUSCO SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
>gi|533226|gb|AAA37663.1| (L32178) GABA transporter [Mus
cookii]
Length = 598
Score = 103 bits (255), Expect = 4e-21
Identities = 132/571 (23%), Positives = 227/571 (39%), Gaps = 92/571 (16%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ RD W + +++ G AIGLGN RFP NGGGAF++PYFL L G+P+ +
Sbjct: 41 LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100
Query: 68 EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
E G+Y G G + P F + GL L+F LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWNVAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143
Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
I W+ Y + S + N +T + F +Y + V FW
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDG 203
Query: 166 ----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQ 215
IT+ + + V + KG+ W ++ + I++I +F G L
Sbjct: 204 LDKPGQIRCLAITLAIAWVLVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLPG 262
Query: 216 PQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVA 275
+ +G F +PN+ L + V L A+ QIFF+ LG+G + SY ++V
Sbjct: 263 AK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVY 316
Query: 276 LSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFS 334
+ +N + G I ++ +A+ K +V A G G +
Sbjct: 317 RDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GLA 363
Query: 335 YTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKTG 390
+ + P Q+ + L+F +L G S + ++TAL++E L R+
Sbjct: 364 FLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYSRLLRNRRELF 422
Query: 391 TWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFWK 445
V I+ +L+G+ +Y+ D A L L F+ + W + + F+
Sbjct: 423 IAAVCIVSYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFYD 481
Query: 446 ELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----AI 495
+ E ++K PI +A + + T+G W + A+
Sbjct: 482 NIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMAL 541
Query: 496 IAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
+M++I AY + K G ++ +V+I+
Sbjct: 542 SSMVLIPGYMAYMFLTLK-GSLKQRLQVMIQ 571
>pir||S65673 GABA transport protein - tobacco hornworm >gi|695378|gb|AAA92342.1|
(L40373) GABA neurotransmitter transporter [Manduca
sexta]
Length = 597
Score = 103 bits (254), Expect = 6e-21
Identities = 123/498 (24%), Positives = 211/498 (41%), Gaps = 86/498 (17%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ +R WA+K+ IL++ G AIGLGN RFP NGGGAF++PYFL LFL GIP+ ++
Sbjct: 32 LPERGSWASKLDFILSVIGLAIGLGNVWRFPYLCYKNGGGAFLIPYFLTLFLAGIPMFFM 91
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
E G+ G G + A IF IG A A + +N YY+ ++
Sbjct: 92 ELAMGQMLTIGGLGVF--------------KIAPIFKGIGYAAA-VMSCWMNVYYIVILA 136
Query: 128 WSAAYSWFSISG--------AYFNVESTAKFFE----SYLSNHGLVFLFW-----GITVV 170
W+ Y + S+ Y+N + ++ + S+ G + F ++
Sbjct: 137 WAIFYFFMSMRSDVPWRNCDNYWNTATCVNPYDRKNLTCWSSLGDMSTFCTLNGRNVSKA 196
Query: 171 LLAIAVGQ-------GVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL---GQPQWST 220
+L+ V + +S GIE + L ++ V+ F + + G+ + T
Sbjct: 197 VLSDPVKEFWERRALQISSGIEHIGNIRWELAGTLLLVWVLCYFCIWKGVRWTGKVVYFT 256
Query: 221 ---------------------IKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMG 259
++G +F PN + L E V + A QIFF+ LG+G
Sbjct: 257 ALFPYFLLTVLLIRGITLPGAMEGIKFYVMPNMSKLLES--EVWIDAVTQIFFSYGLGLG 314
Query: 260 IIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGS 318
+ SY ++V L S+N + G I +V +A+ + EV A G
Sbjct: 315 TLVALGSYNKFTNNVYKDALIVCSVNSSTSMFAGFVIFSVVGFMAHEQQRPVAEVAASGP 374
Query: 319 NAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTAL 378
G ++ + P+ +Q+ A + +F+LL + M ++TA+
Sbjct: 375 -------------GLAFLAYPSAVLQLPGAPLWSCLFFFMLLLIGLDSQFCTMEGFITAV 421
Query: 379 LEEDLGISRKTG---TWIVFIIYFLLGIPVVYING-YLDQV-DAWI--SFQLALLALFDI 431
++E + R+ I II +L+G+ + G Y+ Q+ D++ F L L F+
Sbjct: 422 IDEWPKLLRRRKEIFIAITCIISYLVGLSCISEGGMYVFQILDSYAVSGFCLLFLIFFEC 481
Query: 432 IVGVWLFKPDNFWKELHE 449
+ W F + F+ + E
Sbjct: 482 VSISWAFGVNRFYDGIKE 499
>pir||S68236 betaine/GABA transport protein BGT-1 - human
>gi|881475|gb|AAA87029.1| (U27699) pephBGT-1
betaine-GABA transporter [Homo sapiens]
Length = 614
Score = 102 bits (253), Expect = 8e-21
Identities = 124/528 (23%), Positives = 222/528 (41%), Gaps = 89/528 (16%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
Q++ R +W K+ +L++AG IGLGN RFP NGGGAF +PYF+ F+ GIPV +
Sbjct: 32 QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFF 91
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
+E G+Y + + A + P L G+ G + + LN YY+ ++
Sbjct: 92 LEVALGQYTSQGS---------VTAWRKICP---LFQGI--GLASVVIESYLNVYYIIIL 137
Query: 127 GWSAAYSWFSISGA--------YFNVESTAKF-----------FESYLSN---------- 157
W+ Y + S + ++N E F FE++ S
Sbjct: 138 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVL 197
Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFA 208
H L L W + + LL + + KG++ KV+ + + +++++ +
Sbjct: 198 GITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRG 257
Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYL 268
+ P +G + P+ LK+ V + A QIFF+ ++ G + SY
Sbjct: 258 VTLP------GAYQGIIYYLKPDLFRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYN 309
Query: 269 GPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISEN 328
++ +A LN V G + L + VP +A+
Sbjct: 310 KYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAES----------- 358
Query: 329 FGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL-TALLEEDLGISR 387
G G ++ + P V M + + L+F++L F G S L TA ++ R
Sbjct: 359 -GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLR 416
Query: 388 KTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLAL--LALFDIIVGVWLF 438
K+G + ++ +L+G+ +V G Y+ Q+ D + S + L L+LF+++ W++
Sbjct: 417 KSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVY 476
Query: 439 KPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPL-FGTFTDLVSK 485
D F+ + + + + W V I+ +F+ L TF +SK
Sbjct: 477 GADRFYDNIED-----MIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519
>gi|4507037 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12; Solute carrier family 6
(neurotransmitter transporter, betaine/GABA), [Homo
sapiens] >gi|1352525|sp|P48065|NTBE_HUMAN SODIUM- AND
CHLORIDE-DEPENDENT BETAINE TRANSPORTER
(NA+/CL-BETAINE/GABA TRANSPORTER) (BGT-1)
>gi|2119583|pir||I56522 betaine/GABA transporter - human
>gi|808696|gb|AAA66574.1| (L42300) betaine/GABA
transporter [Homo sapiens]
Length = 614
Score = 102 bits (253), Expect = 8e-21
Identities = 124/528 (23%), Positives = 222/528 (41%), Gaps = 89/528 (16%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
Q++ R +W K+ +L++AG IGLGN RFP NGGGAF +PYF+ F+ GIPV +
Sbjct: 32 QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFF 91
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
+E G+Y + + A + P L G+ G + + LN YY+ ++
Sbjct: 92 LEVALGQYTSQGS---------VTAWRKICP---LFQGI--GLASVVIESYLNVYYIIIL 137
Query: 127 GWSAAYSWFSISGA--------YFNVESTAKF-----------FESYLSN---------- 157
W+ Y + S + ++N E F FE++ S
Sbjct: 138 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVL 197
Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFA 208
H L L W + + LL + + KG++ KV+ + + +++++ +
Sbjct: 198 GITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRG 257
Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYL 268
+ P +G + P+ LK+ V + A QIFF+ ++ G + SY
Sbjct: 258 VTLP------GAYQGIIYYLKPDLFRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYN 309
Query: 269 GPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISEN 328
++ +A LN V G + L + VP +A+
Sbjct: 310 KYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAES----------- 358
Query: 329 FGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL-TALLEEDLGISR 387
G G ++ + P V M + + L+F++L F G S L TA ++ R
Sbjct: 359 -GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLR 416
Query: 388 KTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLAL--LALFDIIVGVWLF 438
K+G + ++ +L+G+ +V G Y+ Q+ D + S + L L+LF+++ W++
Sbjct: 417 KSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVY 476
Query: 439 KPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPL-FGTFTDLVSK 485
D F+ + + + + W V I+ +F+ L TF +SK
Sbjct: 477 GADRFYDNIED-----MIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519
>gb|AAG01287.1|AF246893_1 (AF246893) serotonin transporter [Ovis aries]
Length = 631
Score = 101 bits (250), Expect = 2e-20
Identities = 122/511 (23%), Positives = 212/511 (40%), Gaps = 88/511 (17%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+ ++E
Sbjct: 78 ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + +G + S+ + IF IG A+ + SYY ++ W+
Sbjct: 138 PLGQY---HRNGCI----------SIWTKICPIFKGIGCAICL-IAFYIASYYNTIMAWA 183
Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESYLSN-------- 157
Y SW FS + + ST+ E Y +
Sbjct: 184 LYYLISSFTEQLPWTSCENSWNTGNCTNYFSEDNITWMLHSTSPAEEFYTRHVLQIHRSK 243
Query: 158 --HGLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
L L W + + ++ I + + KG++ KV+ + +F I+++ + G+ L
Sbjct: 244 GLQDLGGLSWQLVLCIMFIFTIIYFSIWKGVKTSGKVVW-VTAIFPYIILLILLVRGATL 302
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
W +G F PNW L E V + A+ QIFF+L G G++ +ASY ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNN 356
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
L T ++N V G I L + +AK + +L +I+
Sbjct: 357 CYQDALVTSAVNCMTSFVSGFVIFTVLGYMAEMRKEDVSEVAKDAGPSLLFIT----YAE 412
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISRKTGTW 392
+ ++P A FF ++FL+L G A + +TA+L+E + K W
Sbjct: 413 AIANMP--------ASTFFAIVFFLMLITLGLDFTFAGLEGVITAVLDEFPHVWAKRREW 464
Query: 393 IVFIIYFLLGIPVVYINGYLDQVDAWISFQLALL------------ALFDIIVGVWLFKP 440
F+LG+ + G L + ++ + LL AL + + W +
Sbjct: 465 ------FVLGVVITCFFGSLVTLTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGI 518
Query: 441 DNFWKELHEGALINVPEFYKWITVIIAPIFI 471
+ F ++ E + F+K V I+P+F+
Sbjct: 519 NQFCIDVKEMLGFSPGWFWKICWVAISPLFL 549
>sp|P31646|NTG2_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 2
>gi|348413|pir||A45078 gamma-aminobutyric acid
transporter protein 2 - rat >gi|202523|gb|AAA40602.1|
(M95762) GABA transporter [Rattus norvegicus]
Length = 602
Score = 101 bits (248), Expect = 3e-20
Identities = 115/492 (23%), Positives = 207/492 (41%), Gaps = 92/492 (18%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R++W K+ +L++AG IGLGN RFP NGGGAF +PY + LF GIPV ++E
Sbjct: 31 EREQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLET 90
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + G + A + P IF IG A + +LLN YY+ ++ W+
Sbjct: 91 ALGQYTNQGG---------ITAWRKICP----IFEGIGYA-SQMIVSLLNVYYIVVLAWA 136
Query: 130 AAYSWFSIS-----GAYFNVESTAKFFESYLSNHGL----------VFLFWGITVVLLAI 174
Y + S + G+ + +T E +N+ L V FW V +
Sbjct: 137 LFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENATSPVIEFWERRV----L 192
Query: 175 AVGQGVSK-GIERWVKVMMPLL-------------------------YVFAVILVIYVFA 208
+ G+ G RW V+ LL + + +++V+ +
Sbjct: 193 KISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRG 252
Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW--SVMLAASGQIFFTLSLGMGIIQNYAS 266
+ P +G +F PN T LW V + A QIFF+ ++ +G + S
Sbjct: 253 VTLP------GAAQGIQFYLYPNIT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGS 302
Query: 267 YLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWIS 326
Y ++ +A LN V G +I L + VP +A+
Sbjct: 303 YNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVPISEVAES--------- 353
Query: 327 ENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGIS 386
G G ++ + P V + + + +F+++ + + + + +TAL++ +
Sbjct: 354 ---GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVF 410
Query: 387 RKTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWL 437
RK IV ++ F +G+ ++ G Y+ Q+ D + + + LL A+F+ + W+
Sbjct: 411 RKKNRREILILIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWV 470
Query: 438 FKPDNFWKELHE 449
+ F+ + +
Sbjct: 471 YGASRFYDNIED 482
>sp|P48055|NTBE_RABIT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
(NA+/CL-BETAINE/GABA TRANSPORTER)
>gi|847860|gb|AAA67953.1| (U26341) Na and Cl dependent
betaine transporter [Oryctolagus cuniculus]
>gi|1587626|prf||2207167A betaine transporter
[Oryctolagus cuniculus]
Length = 614
Score = 101 bits (248), Expect = 3e-20
Identities = 123/519 (23%), Positives = 222/519 (42%), Gaps = 65/519 (12%)
Query: 4 GVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIP 63
G Q + R +W K+ +L++AG IGL N RFP NGGGAF VPYF+ F GIP
Sbjct: 29 GEDQAKDRGQWTNKMEFVLSVAGEIIGLSNVWRFPYLCYKNGGGAFFVPYFIFFFSCGIP 88
Query: 64 VMWVEWVQGRY---GGKYGHGTLGPTFYLMARESLKPRSAL-IFGLIGGALAFATTTLLN 119
V ++E G+Y G + P F + S+ S L ++ +I LA+A L +
Sbjct: 89 VFFLEVALGQYTSQGSVTAWKKICPLFQGIGLASVVIESYLNVYYII--ILAWALFYLFS 146
Query: 120 SYYLHL------IGWSAAYSWFSISGAYFNVESTAKFFESYLSN-------------HGL 160
S+ L W+ Y +++ + + S+ + F S + H L
Sbjct: 147 SFTSELPWTTCTNSWNTEYCQHALNHSGAGIGSSTENFTSPVMEFWERRVLGITAGIHDL 206
Query: 161 VFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQ 217
L W + + LL I + KG++ KV+ + + +++++ + + P
Sbjct: 207 GALRWELALCLLLAWIVCYFCIWKGVKYTGKVVYFTATFPYLMLVILLIRGVTLP----- 261
Query: 218 WSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALS 277
+G + P+ LK+ V + A QIFF+ ++ G + SY ++
Sbjct: 262 -GAYQGIVYYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRD 318
Query: 278 GLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTS 337
+A LN V G + L + VP +A+ G G ++ +
Sbjct: 319 SIALCFLNSATSFVAGFVVFSVLGFMSQEQGVPISEVAES------------GPGLAFIA 366
Query: 338 LPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRKTG-----T 391
P V M + + L+F++L F G S + M +TA ++ RK+G
Sbjct: 367 FPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCMECLVTASVDMFPRQLRKSGRRELLI 425
Query: 392 WIVFIIYFLLGIPVVYING-YLDQVDAWISFQ---LALLALFDIIVGVWLFKPDNFWKEL 447
+ ++ +L+G+ +V G Y+ Q+ + + L L++F+++ W++ D F+ +
Sbjct: 426 LAIAVLCYLIGLLLVTEGGMYIFQLFDYYACSGICLLFLSVFEVVSISWVYGADRFYDNI 485
Query: 448 HEGALINVPEFYKWITVIIAPIFIALPL-FGTFTDLVSK 485
+ + + W V I+ +F+ L TF +SK
Sbjct: 486 QD-----MIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519
>sp|P31648|NTG1_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
>gi|423439|pir||F46027 gamma-aminobutyric acid
transporter - mouse
Length = 598
Score = 100 bits (247), Expect = 4e-20
Identities = 131/572 (22%), Positives = 226/572 (38%), Gaps = 94/572 (16%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ RD W + +++ G AIGLGN RFP NGGGAF++PYFL L G+P+ +
Sbjct: 41 LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100
Query: 68 EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL-LNSYYLH 124
E G+Y G G P F G A+A A + LN YY+
Sbjct: 101 ECSLGQYTSIGGLGVWNWAPMFK------------------GVAVAAAVLSFWLNIYYIV 142
Query: 125 LIGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW--------- 165
+I W+ Y + S + N +T + F +Y + V FW
Sbjct: 143 IISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTD 202
Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
IT+ + + V + KG+ W ++ + I++I +F G L
Sbjct: 203 GLDKPGQIRCLAITLAIAWVLVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 261
Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
+ +G F +PN+ L + V+ A+ QIFF+ LG+G + SY ++V
Sbjct: 262 GAK----EGILFYITPNFRKLSDS--EVIFDAATQIFFSYGLGLGSLIALGSYNSFHNNV 315
Query: 275 ALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
+ +N + G I ++ +A+ K +V A G G
Sbjct: 316 YRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GL 362
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKT 389
++ + P Q+ + L+F +L G S + ++TAL++E L R+
Sbjct: 363 AFLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRREL 421
Query: 390 GTWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFW 444
V I+ +L+G+ +Y+ D A L L F+ + W + + F+
Sbjct: 422 FIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFY 480
Query: 445 KELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----A 494
+ E ++K PI +A + + T+G W + A
Sbjct: 481 DNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMA 540
Query: 495 IIAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
+ +M++I AY + K G ++ +V+I+
Sbjct: 541 LSSMVLIPGYMAYMFLTLK-GSLKQRLQVMIQ 571
>pir||I51368 gamma-aminobutyric acid transport protein GAT-1 - Pacific electric
ray >gi|444010|emb|CAA54394.1| (X77139) GAT-1 GABA
transporter [Torpedo californica]
Length = 598
Score = 99.5 bits (244), Expect = 9e-20
Identities = 113/486 (23%), Positives = 199/486 (40%), Gaps = 82/486 (16%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
++ +R+KW + +L+ G AIGLGN RFP NGGGAF++PYF+ L G+P+
Sbjct: 39 KIPEREKWGGRYDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFMTLIFAGMPIFL 98
Query: 67 VEWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLH 124
+E G+Y G G L P F + GL L+F LN YY+
Sbjct: 99 LECSLGQYTSVGGLGIWRLAPMFKGV-------------GLAAAVLSF----WLNIYYVV 141
Query: 125 LIGWSAAYSWFSISG-----AYFNVESTAKFFESYLSNHGL-----VFLFW--------- 165
+I W+ Y + S + + N +T + F +Y + + FW
Sbjct: 142 IIAWAIYYLYNSFTSELPWQSCGNSWNTDRCFSNYSMTNSTNLSSPIVEFWERNMHQLTD 201
Query: 166 ------------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
IT+ + + V + KG+ W ++ ++ I+++ +F G L
Sbjct: 202 GLDQPGQIRAPLAITLAIAWVLVYFCIWKGVS-WTGKVVYFSAIYPYIMLLTLFFRGVTL 260
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
+ +G F +P++ L + V L A+ QIFF+ LG+G + SY ++
Sbjct: 261 PGAR----EGILFYITPDFRRLSDS--EVWLDAATQIFFSYGLGLGSLVALGSYNKFHNN 314
Query: 274 VALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLG 332
V + +N + G I ++ +A+ +V A G G
Sbjct: 315 VYRDSIIVCCINSTTSMFAGFVIFSIVGFMAHVTNRPIADVAASGP-------------G 361
Query: 333 FSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRK 388
++ + P Q+ + L+F +L G S + ++TAL++E L R+
Sbjct: 362 LAFLAYPEAVTQL-PISPLWSILFFSMLLMLGIDSQFCTVEGFITALVDEFPKLLRGRRE 420
Query: 389 TGTWIVFIIYFLLGIPVV-----YINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNF 443
+V I+ +L+G+ + Y+ D A L L F+ + W + + F
Sbjct: 421 IFIAMVCIVSYLIGLSNITQGGLYVFKLFDYYSA-SGMSLLFLVFFETVSISWCYGVNRF 479
Query: 444 WKELHE 449
+ + E
Sbjct: 480 FVNIEE 485
>gb|AAG20907.1| (AE005157) sodium-dependent transporter; YocR [Halobacterium sp.
NRC-1]
Length = 419
Score = 99.5 bits (244), Expect = 9e-20
Identities = 100/352 (28%), Positives = 159/352 (44%), Gaps = 47/352 (13%)
Query: 53 YFLALFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAF 112
Y L + +G+P + E+V GR G + G L R + R +G G
Sbjct: 2 YLLLVVGIGVPGLLAEFVLGRRGRQTPIGAL--------RSLIGSR----WGTAVGTFNV 49
Query: 113 ATTTLLNSYYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFL-FWGITVVL 171
TT ++ S+Y + GW Y+ S +GAYF ++F ++HGL + F + + +
Sbjct: 50 ITTVVMLSFYSVVGGWILRYTLLSPTGAYF--AQPQQYFSH--ASHGLPAVGFHLLFLGI 105
Query: 172 LAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPN 231
+A+ V GVS+GIER KVM+P + V L ++ Q +T G+ F +
Sbjct: 106 IALIVFFGVSQGIERVSKVMLPAVVVLLGGLAVWTAT--------QPNTAAGYAFYLGFD 157
Query: 232 WTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL-SGLATVSLNEFAEV 290
YL + +SV+ A+GQ FTLSLG G + YASYL DD +L ++++ A
Sbjct: 158 PDYLAANFFSVLGPAAGQALFTLSLGAGAMLTYASYL--DDDASLPRDTVVIAISNTAIG 215
Query: 291 VLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGR 350
VL G + +PL ++ I P +G AL L ++ +LP G
Sbjct: 216 VLAGLVVLPLLISQG--ITP----GQGGPGAL-----FVALATAFGALP--------GGN 256
Query: 351 FFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLG 402
++F + A TS I + A L ++ SR+ T V ++ G
Sbjct: 257 VVATVFFFTVLLAAVTSGINLLETPVATLVDNYNASRRVATAAVTLLLAATG 308
>gi|4507043 solute carrier family 6 (neurotransmitter transporter, serotonin),
member 4; Solute carrier family 6 (neurotransmitter
transporter, serotonin), [Homo sapiens]
>gi|400630|sp|P31645|NTSE_HUMAN SODIUM-DEPENDENT
SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
>gi|476966|pir||A47398 serotonin transporter - human
>gi|36433|emb|CAA50029.1| (X70697) serotonin transporter
[Homo sapiens] >gi|291820|gb|AAA35492.1| (L05568)
Na+/Cl- dependent serotonin transporter [Homo sapiens]
>gi|300444|gb|AAB26687.1| serotonin transporter,
serotonin uptake site, 5-HT uptake site [human,
platelets, Peptide, 630 aa]
Length = 630
Score = 98.7 bits (242), Expect = 1e-19
Identities = 117/505 (23%), Positives = 210/505 (41%), Gaps = 76/505 (15%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+ ++E
Sbjct: 78 ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + +G + S+ + IF IG A+ + SYY ++ W+
Sbjct: 138 ALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTIMAWA 183
Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESY----------- 154
Y SW FS + + ST+ E Y
Sbjct: 184 LYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 243
Query: 155 -LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
L + G + + ++L+ + + KG++ KV+ + F I++ + G+ L
Sbjct: 244 GLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILSVLLVRGATL 302
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
W +G F PNW L E V + A+ QIFF+L G G++ +ASY ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNN 356
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
L T +N V G I L +A+ N + ++++ G
Sbjct: 357 CYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSEVAKDAGPSL 405
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE--DLGISRKTG 390
+ + M A FF ++FL+L G S A + +TA+L+E + R+
Sbjct: 406 LFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRER 464
Query: 391 TWIVFIIYFLLG--IPVVYINGYLDQVDAWISFQLALL--ALFDIIVGVWLFKPDNFWKE 446
+ +I G + + + Y+ ++ + A+L AL + + W + F ++
Sbjct: 465 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRD 524
Query: 447 LHEGALINVPEFYKWITVIIAPIFI 471
+ E + F++ V I+P+F+
Sbjct: 525 VKEMLGFSPGWFWRICWVAISPLFL 549
>gi|7657587 solute carrier family 6 (neurotransmitter transporter, GABA),
member 11 [Homo sapiens]
>gi|1352531|sp|P48066|NTG3_HUMAN SODIUM- AND
CHLORIDE-DEPENDENT GABA TRANSPORTER 3
>gi|913242|gb|AAB33570.1| (S75989) gamma-aminobutyric
acid transporter type 3, GABA transporter type 3, GAT-3
[human, fetal brain, Peptide, 632 aa] [Homo sapiens]
Length = 632
Score = 98.7 bits (242), Expect = 1e-19
Identities = 121/516 (23%), Positives = 215/516 (41%), Gaps = 96/516 (18%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ +R W K+ +L++AG IGLGN RFP NGGGAF++PY + GIPV ++
Sbjct: 47 VHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFL 106
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYLH 124
E G++ + G + + P +F IG +AT + LN YY+
Sbjct: 107 ETALGQFTSEGG---------ITCWRKVCP----LFEGIG----YATQVIEAHLNVYYII 149
Query: 125 LIGWSAAY---------SWFSISGAYFNVESTAKFFESYLSNHGLVFL---------FWG 166
++ W+ Y W + G +N E+ +F + +SN+ V L FW
Sbjct: 150 ILAWAIFYLSNCFTTELPW-ATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWE 208
Query: 167 ITVVLLAIAVGQGVSK-GIERW--------------------VKVMMPLLYV---FAVIL 202
V +A+ G+ G RW K ++YV F I+
Sbjct: 209 HRV----LAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIM 264
Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
++ + G L +G +F P+ + L + V + A QIFF+ ++ +G +
Sbjct: 265 LLILLIRGVTLP----GASEGIKFYLYPDLSRLSDP--QVWVDAGTQIFFSYAICLGCLT 318
Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
SY ++ + LN V G +I L + VP +A+
Sbjct: 319 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAES----- 373
Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEE 381
G G ++ + P V M + L+F++L F G S + + + +TA+++
Sbjct: 374 -------GPGLAFIAYPKA-VTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM 425
Query: 382 -----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDII 432
G R+ + +I + LG+ ++ G Y+ Q+ D++ + + LL A+F+ I
Sbjct: 426 YPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECI 485
Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP 468
W++ + F+ + + P KW +I+ P
Sbjct: 486 CIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTP 521
>gi|11428196 solute carrier family 6 (neurotransmitter transporter, serotonin),
member 4 [Homo sapiens]
Length = 654
Score = 98.7 bits (242), Expect = 1e-19
Identities = 117/505 (23%), Positives = 210/505 (41%), Gaps = 76/505 (15%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ W K+ +L++ G A+ LGN RFP NGGGAF++PY + GIP+ ++E
Sbjct: 102 ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 161
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + +G + S+ + IF IG A+ + SYY ++ W+
Sbjct: 162 ALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTIMAWA 207
Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESY----------- 154
Y SW FS + + ST+ E Y
Sbjct: 208 LYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 267
Query: 155 -LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
L + G + + ++L+ + + KG++ KV+ + F I++ + G+ L
Sbjct: 268 GLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILSVLLVRGATL 326
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
W +G F PNW L E V + A+ QIFF+L G G++ +ASY ++
Sbjct: 327 -PGAW---RGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNN 380
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
L T +N V G I L +A+ N + ++++ G
Sbjct: 381 CYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSEVAKDAGPSL 429
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE--DLGISRKTG 390
+ + M A FF ++FL+L G S A + +TA+L+E + R+
Sbjct: 430 LFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRER 488
Query: 391 TWIVFIIYFLLG--IPVVYINGYLDQVDAWISFQLALL--ALFDIIVGVWLFKPDNFWKE 446
+ +I G + + + Y+ ++ + A+L AL + + W + F ++
Sbjct: 489 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRD 548
Query: 447 LHEGALINVPEFYKWITVIIAPIFI 471
+ E + F++ V I+P+F+
Sbjct: 549 VKEMLGFSPGWFWRICWVAISPLFL 573
>sp|P27799|NTBE_CANFA SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
(NA+/CL-BETAINE/GABA TRANSPORTER) >gi|89018|pir||A41757
betaine transport protein, renal - dog
>gi|455158|gb|AAA30877.1| (M80403) Na+- and Cl-
dependent betaine transporter [Canis familiaris]
>gi|2463606|dbj|BAA22547.1| (D42037) Betain-GABA
transporter [Canis familiaris]
Length = 614
Score = 97.5 bits (239), Expect = 3e-19
Identities = 115/494 (23%), Positives = 204/494 (41%), Gaps = 83/494 (16%)
Query: 4 GVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIP 63
G Q++ R +W K+ +L++AG IGLGN RFP NGGGAF +PYF+ F GIP
Sbjct: 29 GEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFTCGIP 88
Query: 64 VMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYL 123
V ++E G+Y + + A + P L+ G+ G + + LN YY+
Sbjct: 89 VFFLEVALGQYTSQGS---------VTAWRKICP---LLQGI--GLASVVIESYLNIYYI 134
Query: 124 HLIGWSAAYSWFSISGAY--------FNVE-----------STAKFFESYLSN------- 157
++ W+ Y + S + +N E TA E++ S
Sbjct: 135 IILAWALFYLFSSFTSELPWTTCTNTWNTEHCMDFLNHSGARTATSSENFTSPVMEFWER 194
Query: 158 ---------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIY 205
H L L W + + LL + + KG++ KV+ + + +++++
Sbjct: 195 RVLGITSGIHDLGALRWELALCLLLAWLICYFCIWKGVKTTGKVVYFTATFPYLMLVILL 254
Query: 206 VFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYA 265
+ + P +G + P+ LK+ V + A QIFF+ ++ G +
Sbjct: 255 IRGITLP------GAYQGVIYYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALG 306
Query: 266 SYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWI 325
SY ++ +A LN G + L + +P +A+
Sbjct: 307 SYNKYHNNCYRDSIALCFLNSATSFAAGFVVFSILGFMAQEQGLPISEVAES-------- 358
Query: 326 SENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL-TALLEEDLG 384
G G ++ + P V M + + L+F++L F G S L TA ++
Sbjct: 359 ----GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASMDMFPS 413
Query: 385 ISRKTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLAL--LALFDIIVGV 435
RK+G + + +L G+ +V G Y+ Q+ D + S + L LA+F++I
Sbjct: 414 QLRKSGRRELLILAIAVFCYLAGLFLVTEGGMYIFQLFDYYASSGICLLFLAMFEVICIS 473
Query: 436 WLFKPDNFWKELHE 449
W++ D F+ + +
Sbjct: 474 WVYGADRFYDNIED 487
>gb|AAF21642.1|AF032873_1 (AF032873) inebriated protein [Manduca sexta]
Length = 727
Score = 97.5 bits (239), Expect = 3e-19
Identities = 131/568 (23%), Positives = 224/568 (39%), Gaps = 103/568 (18%)
Query: 2 DRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLG 61
D V +R WA KI +LA G ++GLGN RFP +GGGAF++PYF+ L + G
Sbjct: 156 DAAVHLKPRRPFWANKIQFVLACVGYSVGLGNVWRFPYLCYKSGGGAFLIPYFIILLICG 215
Query: 62 IPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSY 121
+P++++E G+Y HG +G +L L G G + + L+++Y
Sbjct: 216 VPMLFMELAIGQY---TAHGPIG---------ALSQICPLFKG--AGLASVVISFLMSTY 261
Query: 122 YLHLIGWSAAY---------SWFSISGAYFNVE----------------STAKFFESYLS 156
Y +I W+ Y W S S + + T +FFE +
Sbjct: 262 YAVIIAWAIYYFFTSFKTEVPWASCSNRWNTDQCWVPNHNHTKPNGSQTPTEQFFERKVL 321
Query: 157 NHGLVFLF-WGITVVLLAIAVGQGVSKGIERW--VKVMMPLLYVFAVI--LVIYVFALGS 211
N + G+ L A V V W +K + Y+ + L+I VF LG
Sbjct: 322 NMSAGIEYPGGMRWELAACLVCAWVLVYFALWKSIKSSAKVRYITTTLPFLLIIVF-LGR 380
Query: 212 PLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPK 271
L G F + P+W LK+ + A+ QIF ++ + G + +ASY
Sbjct: 381 SLTLD--GADGGLRFFFKPDWELLKQS--RPWVNAASQIFNSIGIAFGSMIMFASY---- 432
Query: 272 DDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW------- 324
N F L ++AV L A IV A N A +
Sbjct: 433 -------------NRFDNNFLHDTVAVTLVNAITSLIVGIFTFATIGNIAFEQNTPVKDV 479
Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL- 383
I+++ GL F P +M A + + L+F + G S A+ + +++
Sbjct: 480 IADSPGLLF--VVYPQAIAKM-PASQLWAVLFFFMFLCLGLNSQFAIVEVVVTSIQDGFP 536
Query: 384 GISRKTGTW------IVFIIYFLLGIPVVYING-YLDQVDAWISFQLAL--LALFDIIVG 434
+ RK + +V + L G+P + +G Y+ Q+ + + L++ LA F+++
Sbjct: 537 DMIRKRLVYHELLVLLVCAVSLLCGLPHIIHSGIYVFQLMDYYAASLSITYLAFFEVVAI 596
Query: 435 VWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLV----------- 483
W + + + + ++++ +I +P + + D
Sbjct: 597 AWFYGVGRLSRNIKQMTGRQPSLYFRFCWLIASPALLLALWVASMVDYTPPSYRQYQYPA 656
Query: 484 -SKTLGWPAKIAIIAMLIIGAIEAYYAI 510
++ LGW I+A L + I Y I
Sbjct: 657 WAQALGW-----IMASLSLLCIPVYAVI 679
>sp|P31649|NTG3_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3 (GAT3)
>gi|346709|pir||A44409 gamma-aminobutyric acid transport
protein 3 - mouse
Length = 602
Score = 97.1 bits (238), Expect = 4e-19
Identities = 115/489 (23%), Positives = 202/489 (40%), Gaps = 86/489 (17%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
+R+ W K+ +L++AG IGLGN RFP NGGGAF +PY + LF GIPV ++E
Sbjct: 31 EREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLET 90
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y + G + A + P IF IG A + LLN YY+ ++ W+
Sbjct: 91 ALGQYTNQGG---------ITAWRRICP----IFEGIGYASQMIVS-LLNVYYIVVLAWA 136
Query: 130 AAYSWFSIS-----GAYFNVESTAKFFESYLSNHGL----------VFLFWGITVVLLAI 174
Y + S + G+ + +T E +N + V FW V+ L+
Sbjct: 137 LFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSD 196
Query: 175 AVGQGVSKGIERWVKVMMPLLY-----------------------VFAVILVIYVFALGS 211
+ G RW V+ LL F ++++ + G
Sbjct: 197 GIQH---LGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGV 253
Query: 212 PLGQPQWSTIKGFEFIWSPNWTYLKEHLWS--VMLAASGQIFFTLSLGMGIIQNYASYLG 269
L +G +F PN T LW V + A QIFF+ ++ +G + SY
Sbjct: 254 TLP----GAAQGIQFYLYPNIT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNK 305
Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
++ +A LN + G +I L + VP +A+
Sbjct: 306 YHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAES------------ 353
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKT 389
G G ++ + P V + + + +F+++ + + + + +TAL++ + RK
Sbjct: 354 GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKK 413
Query: 390 G-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFKP 440
IV +I F +G+ ++ G Y+ Q+ D + + + LL A+F+ + W++
Sbjct: 414 NRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGA 473
Query: 441 DNFWKELHE 449
F+ + +
Sbjct: 474 GRFYDNIED 482
>pir||I56506 Na+/Cl(-)-dependent neurotransmitter transporter, brain - rat
>gi|545078|gb|AAC60673.1| (S68944) Na+/Cl(-)-dependent
neurotransmitter transporter [rats, brain, Peptide, 727
aa] [Rattus sp.]
Length = 727
Score = 96.3 bits (236), Expect = 8e-19
Identities = 131/573 (22%), Positives = 225/573 (38%), Gaps = 110/573 (19%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
+ E R W +K+ ILA G ++GLGN RFP NGGGA++VPY + L ++GIP+
Sbjct: 55 LDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLF 114
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
++E G+ + G++G Y+ R S+ I L G YY +
Sbjct: 115 FLELAVGQ---RIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGL-----------YYNVI 160
Query: 126 IGWSAAYSWFSI-------------SGAYFNVE------STAKFF--------ESYLSNH 158
IGWS Y + S +G VE S +F + +S
Sbjct: 161 IGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISES 220
Query: 159 GLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQP 216
G L W +TV LL VG V KGI+ KVM F+ + V A G
Sbjct: 221 G--GLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVM-----YFSSLFPCVVLACFLVRGLL 273
Query: 217 QWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL 276
+ G +++P + + V A+ Q+FF L LG G + ++SY +D+
Sbjct: 274 LRGAVDGILHMFTPKLDKMLDP--QVWREAATQVFFALGLGFGGVIAFSSY-NKQDNNCH 330
Query: 277 SGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF------- 329
A VS F VL ++ V + + I+ + + + + L +++ N
Sbjct: 331 FDAALVSFINFFTSVL-ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIP 389
Query: 330 -GLGFS------YTSLPNIFVQM------------------------GT----------- 347
+ FS Y+ + N+ + + GT
Sbjct: 390 PHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAM 449
Query: 348 ----AGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGI 403
A F+ ++FL+L G S I +T + + + ++ T + F +G+
Sbjct: 450 THFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVSCCVFAFFVGL 509
Query: 404 PVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYK 460
V +G ++ D + + L ++ + + I W++ F +EL E FY
Sbjct: 510 LFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYF 569
Query: 461 WITVIIAPIFIALPLFGTFTDLVSKTLGWPAKI 493
++ ++P+ +A+ + L G+ A I
Sbjct: 570 YMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWI 602
>sp|P31662|NTT4_RAT SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER NTT4
>gi|285126|pir||S27043 neurotransmitter transport
protein - rat >gi|262843|gb|AAB24776.1| (L06434)
neurotransmitter transporter [Rattus sp.]
Length = 727
Score = 95.6 bits (234), Expect = 1e-18
Identities = 131/573 (22%), Positives = 225/573 (38%), Gaps = 110/573 (19%)
Query: 6 IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
+ E R W +K+ ILA G ++GLGN RFP NGGGA++VPY + L ++GIP+
Sbjct: 55 LDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLF 114
Query: 66 WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
++E G+ + G++G Y+ R S+ I L G YY +
Sbjct: 115 FLELAVGQ---RIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGL-----------YYNVI 160
Query: 126 IGWSAAYSWFSI-------------SGAYFNVE------STAKFF--------ESYLSNH 158
IGWS Y + S +G VE S +F + +S
Sbjct: 161 IGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISES 220
Query: 159 GLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQP 216
G L W +TV LL VG V KGI+ KVM F+ + V A G
Sbjct: 221 G--GLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVM-----YFSSLFPYVVLACFLVRGLL 273
Query: 217 QWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL 276
+ G +++P + + V A+ Q+FF L LG G + ++SY +D+
Sbjct: 274 LRGAVDGILHMFTPKLDKMLDP--QVWREAATQVFFALGLGFGGVIAFSSY-NKQDNNCH 330
Query: 277 SGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF------- 329
A VS F VL ++ V + + I+ + + + + L +++ N
Sbjct: 331 FDAALVSFINFFTSVL-ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIP 389
Query: 330 -GLGFS------YTSLPNIFVQM------------------------GT----------- 347
+ FS Y+ + N+ + + GT
Sbjct: 390 PHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAM 449
Query: 348 ----AGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGI 403
A F+ ++FL+L G S I +T + + + ++ T + F +G+
Sbjct: 450 THFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVGL 509
Query: 404 PVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYK 460
V +G ++ D + + L ++ + + I W++ F +EL E FY
Sbjct: 510 LFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYF 569
Query: 461 WITVIIAPIFIALPLFGTFTDLVSKTLGWPAKI 493
++ ++P+ +A+ + L G+ A I
Sbjct: 570 YMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWI 602
>pir||C71376 probable sodium- and chloride- dependent transporter - syphilis
spirochete >gi|3322276|gb|AAC65017.1| (AE001187) sodium-
and chloride- dependent transporter [Treponema pallidum]
Length = 443
Score = 94.8 bits (232), Expect = 2e-18
Identities = 102/430 (23%), Positives = 179/430 (40%), Gaps = 54/430 (12%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R+ + + +G++L+ G A+GL N FP ++ GG F++PYF+ LF L
Sbjct: 8 RELFNSHVGVVLSCVGAAMGLANVWLFPGRLVEFGGVTFLIPYFIFLFGL---------- 57
Query: 71 QGRYG--GKYGHG---TLGPTFYLMARESLKPRSALIFGLIG-GALAFATTTLLNSYYLH 124
R+G G+Y G GP R S + L G G S+Y+
Sbjct: 58 -SRFGLMGEYAFGKTLRCGPV-RAFTRVCETHPSCFLRALRGSGWFPVGVLLATCSFYVV 115
Query: 125 LIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGI 184
+IGW Y FS + A ++ F++ ++ + + + L A V GV KG+
Sbjct: 116 IIGWILRYVVFSCTNALAGTQAHDLFYQVAGTSANVPWTL--AAIALTACVVSAGVQKGV 173
Query: 185 ERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVML 244
ER +MM L Y + Y+F L + W ++ + + + LW L
Sbjct: 174 ERGNIIMMVLFYGVLAFITGYIFTLPN-----AWIGMR--RMLAFQSSSLCNPRLW---L 223
Query: 245 AASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAY 304
A G FF+LSLG + Y SY+ D+ + T +L+ A G A+ L
Sbjct: 224 YALGMSFFSLSLGGAAMVLYGSYMPDTVDIPRTAFQTATLDFLA----SGMSALCL---- 275
Query: 305 APKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAG 364
+P +A + + + G F + ++ + Q+ G L+FL + A
Sbjct: 276 ----IP--------SAWVLGMDVSSGPEFLFVTITRVASQI-PMGVMISVLFFLCVLCAA 322
Query: 365 FTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLA 424
+SAIAM + + R+T TW + ++ + +P +N + + + +
Sbjct: 323 LSSAIAMLEVILESFVHTCTVGRRTLTWSLALVVAFVSLP---LNASMRVFETFTDIVVV 379
Query: 425 LLALFDIIVG 434
+L+ ++G
Sbjct: 380 ILSPLSALMG 389
>gb|AAD10615.1| (U02296) cocaine-sensitive serotonin transporter [Drosophila
melanogaster] >gi|740251|prf||2004470A cocaine-sensitive
serotonin transporter [Drosophila melanogaster]
Length = 581
Score = 94.0 bits (230), Expect = 4e-18
Identities = 127/510 (24%), Positives = 205/510 (39%), Gaps = 92/510 (18%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R+ W K +LA+ G A+ LGN RFP NGGGAF+VPY L L G+P+ ++E
Sbjct: 33 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELA 92
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
G+ F+ S+ R +G A+ + YY +IGW+
Sbjct: 93 LGQ-------------FHRCGCLSIWKRICPALKGVGYAICL-IDIYMGMYYNTIIGWAV 138
Query: 131 AYSWFSISGAY--------FNVE---------------STAKFF------ESYLSNHGLV 161
Y + S + +N E S AK F ESY N GL
Sbjct: 139 YYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERKVLESYKGN-GLD 197
Query: 162 FL----------FWGITVVLLAIAVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALG 210
F+ +G+ VL+ ++ +GV S G WV + P + V++++ V +
Sbjct: 198 FMGPVKPTLALCVFGV-FVLVYFSLWKGVRSAGKVVWVTALAP----YVVLIILLVRGVS 252
Query: 211 SPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGP 270
P +G ++ +P W LK V + A+ QIFF+L G G + +SY
Sbjct: 253 LP------GADEGIKYYLTPEWHKLKNS--KVWIDAASQIFFSLGPGFGTLLALSSYNKF 304
Query: 271 KDDVALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENF 329
++ L T S+N + G I L +AY K +V +G
Sbjct: 305 NNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGP----------- 353
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEE---DLGI 385
G + P M + F+ ++FL+L G S + +TAL +E +G
Sbjct: 354 --GLVFIVYPEAIATM-SGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGR 410
Query: 386 SRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALFDIIV---GV-WLFKPD 441
R+ ++ FL +P + G + V+ + L LF + V GV W + D
Sbjct: 411 RRELFVLLLLAFIFLCALPTMTYGGVV-LVNFLNVYGPGLAILFVVFVEAAGVFWFYGVD 469
Query: 442 NFWKELHEGALINVPEFYKWITVIIAPIFI 471
F ++ + F++ I+P+F+
Sbjct: 470 RFSSDVEQMLGSKPGLFWRICWTYISPVFL 499
>sp|P51905|NTSE_DROME SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
(COCAINE-SENSITIVE SEROTONIN TRANSPORTER)
>gi|506640|gb|AAA19430.1| (U04809) cocaine-sensitive
serotonin transporter [Drosophila melanogaster]
>gi|7291780|gb|AAF47200.1| (AE003464) SerT gene product
[Drosophila melanogaster]
Length = 622
Score = 94.0 bits (230), Expect = 4e-18
Identities = 127/510 (24%), Positives = 205/510 (39%), Gaps = 92/510 (18%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R+ W K +LA+ G A+ LGN RFP NGGGAF+VPY L L G+P+ ++E
Sbjct: 74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELA 133
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
G+ F+ S+ R +G A+ + YY +IGW+
Sbjct: 134 LGQ-------------FHRCGCLSIWKRICPALKGVGYAICL-IDIYMGMYYNTIIGWAV 179
Query: 131 AYSWFSISGAY--------FNVE---------------STAKFF------ESYLSNHGLV 161
Y + S + +N E S AK F ESY N GL
Sbjct: 180 YYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERKVLESYKGN-GLD 238
Query: 162 FL----------FWGITVVLLAIAVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALG 210
F+ +G+ VL+ ++ +GV S G WV + P + V++++ V +
Sbjct: 239 FMGPVKPTLALCVFGV-FVLVYFSLWKGVRSAGKVVWVTALAP----YVVLIILLVRGVS 293
Query: 211 SPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGP 270
P +G ++ +P W LK V + A+ QIFF+L G G + +SY
Sbjct: 294 LP------GADEGIKYYLTPEWHKLKNS--KVWIDAASQIFFSLGPGFGTLLALSSYNKF 345
Query: 271 KDDVALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENF 329
++ L T S+N + G I L +AY K +V +G
Sbjct: 346 NNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGP----------- 394
Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEE---DLGI 385
G + P M + F+ ++FL+L G S + +TAL +E +G
Sbjct: 395 --GLVFIVYPEAIATM-SGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGR 451
Query: 386 SRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALFDIIV---GV-WLFKPD 441
R+ ++ FL +P + G + V+ + L LF + V GV W + D
Sbjct: 452 RRELFVLLLLAFIFLCALPTMTYGGVV-LVNFLNVYGPGLAILFVVFVEAAGVFWFYGVD 510
Query: 442 NFWKELHEGALINVPEFYKWITVIIAPIFI 471
F ++ + F++ I+P+F+
Sbjct: 511 RFSSDVEQMLGSKPGLFWRICWTYISPVFL 540
>pir||JH0674 L-proline transport protein - rat
Length = 637
Score = 92.8 bits (227), Expect = 9e-18
Identities = 112/495 (22%), Positives = 202/495 (40%), Gaps = 78/495 (15%)
Query: 2 DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
D+G + ++ R W K+ +L+ G +GLGN RFP + NGGGAF+VPYFL
Sbjct: 23 DQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82
Query: 57 LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
L + GIP+ ++E G++ +LGP K A + LI G +A
Sbjct: 83 LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135
Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
++ +L + W +W++ +GA N+ ST E Y S
Sbjct: 136 IIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWS 195
Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
+ L + W + + LL + V + KG++ KV+ + + ++L
Sbjct: 196 RYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255
Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
++ V + P KG +F +P + +L V + A+ QIF++L +G G +
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307
Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
+ASY ++ N ++ G +I L VP + +AK
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362
Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
G G ++ P + F+ L+F +L G S A + +TA+ +E
Sbjct: 363 -------GPGLAFVIYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414
Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
L + + ++ + +L+G+ + G LD A SF L ++ + +
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472
Query: 434 GVWLFKPDNFWKELH 448
++ F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487
>sp|P28573|NTPR_RAT SODIUM-DEPENDENT PROLINE TRANSPORTER >gi|205235|gb|AAA41541.1|
(M88111) high affinity L-proline transporter [Rattus
norvegicus]
Length = 661
Score = 92.8 bits (227), Expect = 9e-18
Identities = 112/495 (22%), Positives = 202/495 (40%), Gaps = 78/495 (15%)
Query: 2 DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
D+G + ++ R W K+ +L+ G +GLGN RFP + NGGGAF+VPYFL
Sbjct: 23 DQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82
Query: 57 LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
L + GIP+ ++E G++ +LGP K A + LI G +A
Sbjct: 83 LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135
Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
++ +L + W +W++ +GA N+ ST E Y S
Sbjct: 136 IIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWS 195
Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
+ L + W + + LL + V + KG++ KV+ + + ++L
Sbjct: 196 RYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255
Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
++ V + P KG +F +P + +L V + A+ QIF++L +G G +
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307
Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
+ASY ++ N ++ G +I L VP + +AK
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362
Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
G G ++ P + F+ L+F +L G S A + +TA+ +E
Sbjct: 363 -------GPGLAFVIYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414
Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
L + + ++ + +L+G+ + G LD A SF L ++ + +
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472
Query: 434 GVWLFKPDNFWKELH 448
++ F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487
>sp|P31647|NTG3_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3
>gi|285089|pir||JH0695 gamma-aminobutyric acid
transporter protein 3 - rat >gi|202535|gb|AAA40607.1|
(M95763) GABA transporter [Rattus norvegicus]
>gi|204220|gb|AAA41183.1| (M95738)
beta-alanine-sensitive neuronal GABA transporter [Rattus
norvegicus] >gi|253467|gb|AAB22850.1| (S42358) GABA
transporter, GAT-B=beta-alanine-sensitive protein [rats,
midbrain, neurons, Peptide, 627 aa] [Rattus sp.]
Length = 627
Score = 92.8 bits (227), Expect = 9e-18
Identities = 118/516 (22%), Positives = 210/516 (39%), Gaps = 96/516 (18%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ +R W K+ +L++AG IGLGN RFP NGGGAF++PY + GIPV ++
Sbjct: 42 VHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFL 101
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYLH 124
E G++ + G + R +F IG +AT + LN YY+
Sbjct: 102 ETALGQFTSEGG-------------ITCWRRVCPLFEGIG----YATQVIEAHLNVYYII 144
Query: 125 LIGWSAAY---------SWFSISGAYFNVESTAKFFESYLSNHGLVFL---------FWG 166
++ W+ Y W + G +N E +F + SN+ V L FW
Sbjct: 145 ILAWAIFYLSNCFTTELPW-ATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWE 203
Query: 167 ITVVLLAIAVGQGVSK-GIERW--------------------VKVMMPLLYV---FAVIL 202
V +A+ G+ G RW K ++YV F I+
Sbjct: 204 RRV----LAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIM 259
Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
++ + G L +G +F P+ + L + V + A QIFF+ ++ +G +
Sbjct: 260 LLILLIRGVTLP----GASEGIKFYLYPDLSRLSDP--QVWVDAGTQIFFSYAICLGCLT 313
Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
SY ++ + LN V G +I L + VP +A+
Sbjct: 314 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAES----- 368
Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEE 381
G G ++ + P V M + L+F++L F G S + + + +TA+++
Sbjct: 369 -------GPGLAFIAYPKA-VTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM 420
Query: 382 -----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDII 432
G R+ + I+ + LG+ ++ G Y+ Q+ D++ + + LL A+F+ +
Sbjct: 421 YPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECV 480
Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP 468
W++ + F+ + + KW ++ P
Sbjct: 481 CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTP 516
>sp|P31650|NTG4_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 4 (GAT4)
>gi|346710|pir||B44409 gamma-aminobutyric acid
transporter 4, GAT4 - mouse
Length = 627
Score = 90.5 bits (221), Expect = 4e-17
Identities = 118/516 (22%), Positives = 206/516 (39%), Gaps = 96/516 (18%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ +R W K+ +L++AG IGLGN RFP NGGGAF++PY + GIPV ++
Sbjct: 42 VHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFL 101
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYLH 124
E G++ + G + R +F IG +AT + LN YY+
Sbjct: 102 ETALGQFTSEGG-------------ITCWRRVCPLFEGIG----YATQVIEAHLNVYYII 144
Query: 125 LIGWSAAY---------SWFSISGAYFNVESTAKFFESYLSNHGLVFL---------FWG 166
++ W+ Y W + G +N E +F + SN+ V L FW
Sbjct: 145 ILAWAIFYLSNCFTTELPW-ATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWE 203
Query: 167 ITVVLLAIAVGQGVSK-GIERW--------------------VKVMMPLLYV---FAVIL 202
V +A+ G+ G RW K ++YV F I+
Sbjct: 204 RRV----LAISDGIEHIGNLRWELALCLLAGWTICYFCIWKGTKSTGKVVYVTATFPYIM 259
Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
++ + G L +G +F P+ + L + V + A QIFF+ ++ +G +
Sbjct: 260 LLILLIRGVTLP----GASEGIKFYLYPDLSRLSDP--QVWVDAGTQIFFSYAICLGCLT 313
Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
SY ++ + LN V G +I L + VP +A+
Sbjct: 314 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAES----- 368
Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEE 381
G G ++ + P V M + L+F++L F G S + + + +TA+++
Sbjct: 369 -------GPGLAFIAYPKA-VTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM 420
Query: 382 -----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV---DAWISFQLALLALFDII 432
G R+ + II + LG+ ++ G Y+ Q+ A L +A+F+ +
Sbjct: 421 YPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFGSYAASGMCLLFVAIFECV 480
Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP 468
W++ + F+ + + KW ++ P
Sbjct: 481 CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTP 516
>gi|7657589 solute carrier family 6 (neurotransmitter transporter, L-proline),
member 7; brain-specific L-proline transporter [Homo
sapiens] >gi|3024229|sp|Q99884|NTPR_HUMAN
SODIUM-DEPENDENT PROLINE TRANSPORTER
>gi|8176779|gb|AAB47007.2| (S80071) brain-specific
L-proline transporter [Homo sapiens]
Length = 636
Score = 90.5 bits (221), Expect = 4e-17
Identities = 111/495 (22%), Positives = 201/495 (40%), Gaps = 78/495 (15%)
Query: 2 DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
D+G + ++ R W K+ +L+ G +GLGN RFP + NGGGAF+VPYFL
Sbjct: 23 DQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82
Query: 57 LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
L + GIP+ ++E G++ +LGP K A + LI G +A
Sbjct: 83 LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135
Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
++ +L + W +W++ +GA N+ T E Y S
Sbjct: 136 IIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWS 195
Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
+ L + W + + LL + V + KG++ KV+ + + ++L
Sbjct: 196 RYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255
Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
++ V + P KG +F +P + +L V + A+ QIF++L +G G +
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307
Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
+ASY ++ N ++ G +I L VP + +AK
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362
Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
G G ++ P + F+ L+F +L G S A + +TA+ +E
Sbjct: 363 -------GPGLAFVVYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414
Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
L + + ++ + +L+G+ + G LD A SF L ++ + +
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472
Query: 434 GVWLFKPDNFWKELH 448
++ F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487
>gi|11416778 solute carrier family 6 (neurotransmitter transporter, L-proline),
member 7 [Homo sapiens]
Length = 636
Score = 90.5 bits (221), Expect = 4e-17
Identities = 111/495 (22%), Positives = 201/495 (40%), Gaps = 78/495 (15%)
Query: 2 DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
D+G + ++ R W K+ +L+ G +GLGN RFP + NGGGAF+VPYFL
Sbjct: 23 DQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82
Query: 57 LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
L + GIP+ ++E G++ +LGP K A + LI G +A
Sbjct: 83 LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135
Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
++ +L + W +W++ +GA N+ T E Y S
Sbjct: 136 IIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWS 195
Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
+ L + W + + LL + V + KG++ KV+ + + ++L
Sbjct: 196 RYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255
Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
++ V + P KG +F +P + +L V + A+ QIF++L +G G +
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307
Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
+ASY ++ N ++ G +I L VP + +AK
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362
Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
G G ++ P + F+ L+F +L G S A + +TA+ +E
Sbjct: 363 -------GPGLAFVVYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414
Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
L + + ++ + +L+G+ + G LD A SF L ++ + +
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472
Query: 434 GVWLFKPDNFWKELH 448
++ F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487
>gi|11434830 solute carrier family 6 (neurotransmitter transporter, GABA),
member 1 [Homo sapiens]
Length = 358
Score = 90.1 bits (220), Expect = 6e-17
Identities = 85/319 (26%), Positives = 131/319 (40%), Gaps = 57/319 (17%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ RD W + +++ G AIGLGN RFP NGGGAF++PYFL L G+P+ +
Sbjct: 41 LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100
Query: 68 EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
E G+Y G G L P F + GL L+F LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWKLAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143
Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
I W+ Y + S + N +T + F +Y + V FW
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDG 203
Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
IT+ + I V + KG+ W ++ + I++I +F G L
Sbjct: 204 LDKPGQIRWPLAITLAIAWILVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 262
Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
+ +G F +PN+ L + V L A+ QIFF+ LG+G + SY ++V
Sbjct: 263 GAK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNV 316
Query: 275 ALSGLATVSLNEFAEVVLG 293
+ +N + G
Sbjct: 317 YRDSIIVCCINSCTSMFAG 335
>gb|AAF45873.2| (AE003427) CG10804 gene product [Drosophila melanogaster]
Length = 662
Score = 89.3 bits (218), Expect = 1e-16
Identities = 125/540 (23%), Positives = 216/540 (39%), Gaps = 86/540 (15%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
E+R+ W +KI +LA G A+GLGN RFP NGGGAF+VPYF+ L + GIP+ ++E
Sbjct: 52 EERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLE 111
Query: 69 WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
G+ + G +G + S + G+ G + + ++ YY +I W
Sbjct: 112 LAIGQ---RLRKGAIGVWSQV---------SPYLGGI--GISSAVVSYIVALYYNTIIAW 157
Query: 129 SAAYSWFSISGAYFNVESTAKFFESYLSNH-------GLVFLFWGITVV----------- 170
Y S + + ++++ +H +W T +
Sbjct: 158 CLIYLLHSFESPLPWADCPTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPEN 217
Query: 171 --------------LLAIAVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQ 215
L+ I + QG+ S G ++ + P V+L+I+ F G
Sbjct: 218 FNYHMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPY-----VVLIIFFFR-----GI 267
Query: 216 PQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKD--- 272
G +++P W L + + V L A QIFF+L L G + ++SY +
Sbjct: 268 TLKGAADGVAHLFTPRWETLLDPV--VWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCY 325
Query: 273 -DVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLA---KGSNAALQWISEN 328
D L L + FA VV+ I + L K N + +
Sbjct: 326 RDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTE 385
Query: 329 FGLGFSYTSLPNIF----VQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEEDL 383
S T L I + + + L+FL+L+ G S + +T+L++ L
Sbjct: 386 LANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKL 445
Query: 384 GISRKTGTWIVFIIYFLLGIPVVYING---YLDQ-VDAWI-SFQLALLALFD-----IIV 433
+ + + + I + + NG Y+ Q +D++ +F L ++ALF+ I
Sbjct: 446 FPNLPKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIY 505
Query: 434 GVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLGWPAKI 493
GV F D E+ G+ N + W ++P + L +F L+++ +PA I
Sbjct: 506 GVRRFSDD---IEMMTGSRPNFYWMFCW--KYLSPCAMVTILLASFYQLLTEGSSYPAWI 560
>gb|AAC47292.1| (U66460) inebriated [Drosophila melanogaster]
Length = 658
Score = 89.3 bits (218), Expect = 1e-16
Identities = 111/496 (22%), Positives = 200/496 (39%), Gaps = 82/496 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
++ WA K+ +LA G ++GLGN RFP +GGG F+VPY + LF+ IP++++E
Sbjct: 51 RQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMEL 110
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y G+ G LG L G + + L+++YY +IG+S
Sbjct: 111 SVGQYTGRGPIGALGQLCPLFKG--------------AGLASVVVSFLMSTYYSVIIGYS 156
Query: 130 AAYSWFSI-----------------------SGAYFNVESTAK-----FFESYL--SNHG 159
Y + S G + T++ FFE+ + + G
Sbjct: 157 IYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGG 216
Query: 160 LVF---LFWGITVVLLA--IAVGQGVSKGIERWVKV-MMPLLYVFAVILVIYVFALGSPL 213
L + + W + L+ + V K I+ KV + F +I+++ V A+
Sbjct: 217 LEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLD- 275
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
+G F + P W+ LK +V + A+ Q F +L + G + ++ASY ++
Sbjct: 276 -----GAAEGLRFFFRPKWSELKNA--NVWINAASQNFNSLGITFGSMISFASYNKYNNN 328
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
+ +A ++N +++G +A + L + +N I + G G
Sbjct: 329 ILRDTVAVSAVNMITSLLVG---------IFAFSTLGNLALEQNTNVR-DVIGD--GPGM 376
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL--GISRKTG- 390
+ P +M A + + ++F +L G S A+ + +++ I R G
Sbjct: 377 IFVVYPQAMAKMPYA-QLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 435
Query: 391 ----TWIVFIIYFLLGIPVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNF 443
V +I L G+P + G Y +D + S + LA +I W +
Sbjct: 436 HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 495
Query: 444 WKELHEGALINVPEFY 459
K + + P FY
Sbjct: 496 SKNVKQ-MTGKAPSFY 510
>emb|CAA69649.1| (Y08362) neurotransmitter transporter [Drosophila melanogaster]
Length = 943
Score = 89.3 bits (218), Expect = 1e-16
Identities = 111/496 (22%), Positives = 200/496 (39%), Gaps = 82/496 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
++ WA K+ +LA G ++GLGN RFP +GGG F+VPY + LF+ IP++++E
Sbjct: 336 RQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMEL 395
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y G+ G LG L G + + L+++YY +IG+S
Sbjct: 396 SVGQYTGRGPIGALGQLCPLFKG--------------AGLASVVVSFLMSTYYSVIIGYS 441
Query: 130 AAYSWFSI-----------------------SGAYFNVESTAK-----FFESYL--SNHG 159
Y + S G + T++ FFE+ + + G
Sbjct: 442 IYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGG 501
Query: 160 LVF---LFWGITVVLLA--IAVGQGVSKGIERWVKV-MMPLLYVFAVILVIYVFALGSPL 213
L + + W + L+ + V K I+ KV + F +I+++ V A+
Sbjct: 502 LEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLD- 560
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
+G F + P W+ LK +V + A+ Q F +L + G + ++ASY ++
Sbjct: 561 -----GAAEGLRFFFRPKWSELKNA--NVWINAASQNFNSLGITFGSMISFASYNKYNNN 613
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
+ +A ++N +++G +A + L + +N I + G G
Sbjct: 614 ILRDTVAVSAVNMITSLLVG---------IFAFSTLGNLALEQNTNVR-DVIGD--GPGM 661
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL--GISRKTG- 390
+ P +M A + + ++F +L G S A+ + +++ I R G
Sbjct: 662 IFVVYPQAMAKMPYA-QLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 720
Query: 391 ----TWIVFIIYFLLGIPVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNF 443
V +I L G+P + G Y +D + S + LA +I W +
Sbjct: 721 HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 780
Query: 444 WKELHEGALINVPEFY 459
K + + P FY
Sbjct: 781 SKNVKQ-MTGKAPSFY 795
>gb|AAF51001.1| (AE003576) ine gene product [Drosophila melanogaster]
Length = 943
Score = 89.3 bits (218), Expect = 1e-16
Identities = 111/496 (22%), Positives = 200/496 (39%), Gaps = 82/496 (16%)
Query: 10 QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
++ WA K+ +LA G ++GLGN RFP +GGG F+VPY + LF+ IP++++E
Sbjct: 336 RQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMEL 395
Query: 70 VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
G+Y G+ G LG L G + + L+++YY +IG+S
Sbjct: 396 SVGQYTGRGPIGALGQLCPLFKG--------------AGLASVVVSFLMSTYYSVIIGYS 441
Query: 130 AAYSWFSI-----------------------SGAYFNVESTAK-----FFESYL--SNHG 159
Y + S G + T++ FFE+ + + G
Sbjct: 442 IYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGG 501
Query: 160 LVF---LFWGITVVLLA--IAVGQGVSKGIERWVKV-MMPLLYVFAVILVIYVFALGSPL 213
L + + W + L+ + V K I+ KV + F +I+++ V A+
Sbjct: 502 LEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLD- 560
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
+G F + P W+ LK +V + A+ Q F +L + G + ++ASY ++
Sbjct: 561 -----GAAEGLRFFFRPKWSELKNA--NVWINAASQNFNSLGITFGSMISFASYNKYNNN 613
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
+ +A ++N +++G +A + L + +N I + G G
Sbjct: 614 ILRDTVAVSAVNMITSLLVG---------IFAFSTLGNLALEQNTNVR-DVIGD--GPGM 661
Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL--GISRKTG- 390
+ P +M A + + ++F +L G S A+ + +++ I R G
Sbjct: 662 IFVVYPQAMAKMPYA-QLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 720
Query: 391 ----TWIVFIIYFLLGIPVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNF 443
V +I L G+P + G Y +D + S + LA +I W +
Sbjct: 721 HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 780
Query: 444 WKELHEGALINVPEFY 459
K + + P FY
Sbjct: 781 SKNVKQ-MTGKAPSFY 795
>gi|8394204 X transporter protein 2 [Rattus norvegicus]
>gi|531469|gb|AAC13771.1| (U12973) renal osmotic
stress-induced Na-Cl organic solute cotransporter
[Rattus norvegicus] >gi|1092855|prf||2102185A ROSIT
[Rattus norvegicus]
Length = 615
Score = 88.9 bits (217), Expect = 1e-16
Identities = 88/318 (27%), Positives = 140/318 (43%), Gaps = 52/318 (16%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MD V ++R KW K+ +L+ G A+GLGN RFP +GGGAF++PYF+AL
Sbjct: 7 MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFE 66
Query: 61 GIPVMWVEWVQGR---------------YGGKYGHGTLGPTFYLMARESLKPRSALIFGL 105
GIP+ ++E G+ Y G G G +F + +L +
Sbjct: 67 GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLV----------SLYYNT 116
Query: 106 IGGALAFATTTLLNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYL 155
I L + LNS+ H + WS + +G +S T +F S +
Sbjct: 117 I---LLWVLWFFLNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDI 172
Query: 156 SNHGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSP 212
SN G + W + + L+A V V +GIE KV+ L+ + V+ + + L P
Sbjct: 173 SNTGTI--QWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP 230
Query: 213 LGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKD 272
+G ++++PN L+ V L A+ QIFF+LSL G +ASY P++
Sbjct: 231 ------GATEGLTYLFTPNMKILQNS--RVWLDAATQIFFSLSLAFGGHIAFASYNQPRN 282
Query: 273 DVALSGLATVSLNEFAEV 290
+ + +N +
Sbjct: 283 NCEKDAVTIALVNSMTSL 300
>gb|AAF98299.1|AF237673_1 (AF237673) norepinephrine transporter [Gallus gallus]
Length = 635
Score = 88.5 bits (216), Expect = 2e-16
Identities = 125/555 (22%), Positives = 230/555 (40%), Gaps = 89/555 (16%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
+ R+ W KI +L++ G A+ L N RFP NGGGAF++PY L L + G+P+ ++E
Sbjct: 72 QDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYILFLIIAGMPLFYME 131
Query: 69 WVQGRYGGKYGHGT---LGPTFYLMARESLKPRSALIFGLIGGA-LAFATTTLLNSYYLH 124
G+Y + G T + P F + + AL G +A++ L +S+
Sbjct: 132 LALGQY-NREGAATVWKICPVFKGVGYAVI--LIALYVGFYYNVIIAWSLYYLFSSFTFE 188
Query: 125 LIGWSAAYSW------------FSISG-----AYFNVESTAKFFESYLSN-------HGL 160
L + SW S+ G + + + A+F+E + + H L
Sbjct: 189 LPWTNCDNSWNSPNCTDPKLFNASVLGNGTKYSKYKLTPAAEFYERGVLHLHESRGIHDL 248
Query: 161 VFLFWGITVVLLAIAV------GQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
W +++ LL + + +GV + G W+ +P YV +L+I+ L
Sbjct: 249 GLPRWQLSLCLLVVVIILFFSLWKGVKTSGKVVWITATLP--YVVLFVLLIHGITLP--- 303
Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
G ++ LKE +V + A+ QIF++L G G++ +ASY ++
Sbjct: 304 -----GAYNGINAYLHIDFRRLKEA--TVWIDAATQIFYSLGAGFGVLIAFASYNKFDNN 356
Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENFGLG 332
L T ++N + G +I L +A+ K+ +V +G+ G
Sbjct: 357 CYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGA-------------G 403
Query: 333 FSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGI---SRKT 389
+ P + + F+ ++F++L G S++ + L +D I RK
Sbjct: 404 LVFILYPEAISTL-SGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFHILKQHRKL 462
Query: 390 GTWIVFIIYFLLGIPVVYING--YLDQVDAWISFQLALLALFDIIVGV-WLFKPDNFWKE 446
T+ V FLL + + G L +D + + L A+ +GV W + D F ++
Sbjct: 463 FTFGVSFGTFLLALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSED 522
Query: 447 LHEGALINVPEFYKWITVIIAPIFIAL----------PLFGTFTDLV----SKTLGWPAK 492
+ + +++ ++P F+ PL T+ D + +GW
Sbjct: 523 IQQMMGFKPGLYWRLCWKFVSPAFLLFVVIVSIINFKPL--TYDDYTFPFWANRIGW--G 578
Query: 493 IAIIAMLIIGAIEAY 507
IA+ +M+++ A Y
Sbjct: 579 IALSSMILVPAYVIY 593
>gb|AAC27757.1| (AF075262) orphan transporter isoform A12 [Mus musculus]
Length = 615
Score = 87.8 bits (214), Expect = 3e-16
Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MD V ++R KW K+ +L+ G A+GLGN RFP +GGGAF++PYF+AL
Sbjct: 7 MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66
Query: 61 GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
GIP+ ++E G R G T+ P + S L+ L +
Sbjct: 67 GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125
Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
LNS+ H + WS + +G +S T +F S +SN G + W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182
Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
+ L+A V V +GIE KV+ L+ + V+ + + L P +G
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236
Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
++++PN L+ V L A+ QIFF+LSL G +ASY P+++ + +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294
Query: 285 NEFAEVVLGGSIAV 298
N L SIA+
Sbjct: 295 NSMTS--LYASIAI 306
>gb|AAC27758.1| (AF075263) orphan transporter isoform A11 [Mus musculus]
Length = 605
Score = 87.8 bits (214), Expect = 3e-16
Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MD V ++R KW K+ +L+ G A+GLGN RFP +GGGAF++PYF+AL
Sbjct: 7 MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66
Query: 61 GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
GIP+ ++E G R G T+ P + S L+ L +
Sbjct: 67 GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125
Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
LNS+ H + WS + +G +S T +F S +SN G + W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182
Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
+ L+A V V +GIE KV+ L+ + V+ + + L P +G
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236
Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
++++PN L+ V L A+ QIFF+LSL G +ASY P+++ + +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294
Query: 285 NEFAEVVLGGSIAV 298
N L SIA+
Sbjct: 295 NSMTS--LYASIAI 306
>gb|AAC27759.1| (AF075264) orphan transporter isoform B11 [Mus musculus]
Length = 577
Score = 87.8 bits (214), Expect = 3e-16
Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MD V ++R KW K+ +L+ G A+GLGN RFP +GGGAF++PYF+AL
Sbjct: 7 MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66
Query: 61 GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
GIP+ ++E G R G T+ P + S L+ L +
Sbjct: 67 GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125
Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
LNS+ H + WS + +G +S T +F S +SN G + W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182
Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
+ L+A V V +GIE KV+ L+ + V+ + + L P +G
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236
Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
++++PN L+ V L A+ QIFF+LSL G +ASY P+++ + +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294
Query: 285 NEFAEVVLGGSIAV 298
N L SIA+
Sbjct: 295 NSMTS--LYASIAI 306
>gb|AAC27760.1| (AF075265) orphan transporter isoform A10 [Mus musculus]
Length = 552
Score = 87.8 bits (214), Expect = 3e-16
Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MD V ++R KW K+ +L+ G A+GLGN RFP +GGGAF++PYF+AL
Sbjct: 7 MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66
Query: 61 GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
GIP+ ++E G R G T+ P + S L+ L +
Sbjct: 67 GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125
Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
LNS+ H + WS + +G +S T +F S +SN G + W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182
Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
+ L+A V V +GIE KV+ L+ + V+ + + L P +G
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236
Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
++++PN L+ V L A+ QIFF+LSL G +ASY P+++ + +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294
Query: 285 NEFAEVVLGGSIAV 298
N L SIA+
Sbjct: 295 NSMTS--LYASIAI 306
>gb|AAC27761.1| (AF075266) orphan transporter isoform B9 [Mus musculus]
Length = 514
Score = 87.8 bits (214), Expect = 3e-16
Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MD V ++R KW K+ +L+ G A+GLGN RFP +GGGAF++PYF+AL
Sbjct: 7 MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66
Query: 61 GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
GIP+ ++E G R G T+ P + S L+ L +
Sbjct: 67 GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125
Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
LNS+ H + WS + +G +S T +F S +SN G + W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182
Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
+ L+A V V +GIE KV+ L+ + V+ + + L P +G
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236
Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
++++PN L+ V L A+ QIFF+LSL G +ASY P+++ + +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294
Query: 285 NEFAEVVLGGSIAV 298
N L SIA+
Sbjct: 295 NSMTS--LYASIAI 306
>gi|6756029 X transporter protein 2 [Mus musculus] >gi|3347932|gb|AAC27762.1|
(AF075267) orphan transporter isoform A8 [Mus musculus]
Length = 422
Score = 87.8 bits (214), Expect = 3e-16
Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)
Query: 1 MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
MD V ++R KW K+ +L+ G A+GLGN RFP +GGGAF++PYF+AL
Sbjct: 7 MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66
Query: 61 GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
GIP+ ++E G R G T+ P + S L+ L +
Sbjct: 67 GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125
Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
LNS+ H + WS + +G +S T +F S +SN G + W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182
Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
+ L+A V V +GIE KV+ L+ + V+ + + L P +G
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236
Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
++++PN L+ V L A+ QIFF+LSL G +ASY P+++ + +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294
Query: 285 NEFAEVVLGGSIAV 298
N L SIA+
Sbjct: 295 NSMTS--LYASIAI 306
>gb|AAF89166.1|AF230787_1 (AF230787) norepinephrine transporter [Coturnix japonica]
Length = 515
Score = 86.6 bits (211), Expect = 6e-16
Identities = 122/553 (22%), Positives = 224/553 (40%), Gaps = 99/553 (17%)
Query: 12 DKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQ 71
+ W KI +L++ G A+ L N RFP NGGGAF++PY L L + G+P+ ++E
Sbjct: 1 ENWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYILFLIIAGMPLFYMELAL 60
Query: 72 GRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAA 131
G+Y + G T+ + +F +G A+ + YY +I WS
Sbjct: 61 GQY-NREGAATVW-------------KICPVFKGVGYAV-ILIALYVGFYYNVIIAWSLY 105
Query: 132 Y---------SWFSISGAYFNVEST-AKFFESYLSNHGLVFLFWGITVV-------LLAI 174
Y W + ++ N T K F + + +G + + +T +L +
Sbjct: 106 YLFSSFTFELPWTNCDNSWNNPNCTNPKLFNASVLGNGTKYSKYKLTPAAEFYERGVLHL 165
Query: 175 AVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALGSPL---GQPQWST---------- 220
+G+ G+ RW L V+++I F+L + G+ W T
Sbjct: 166 HESRGIHDLGLPRW-----QLSLCLLVVVIILFFSLWKGVKTSGKVVWITATLPYVVLFV 220
Query: 221 --IKGFEFIWSPNWTYLKEHL-------WSVMLAASGQIFFTLSLGMGIIQNYASYLGPK 271
I G + N H+ +V + A+ QIF++L G G++ +ASY
Sbjct: 221 LLIHGITLPGAYNGINAYLHIDFRRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNRFD 280
Query: 272 DDVALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENFG 330
++ L T ++N + G +I L +A+ K+ +V +G+
Sbjct: 281 NNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGA------------ 328
Query: 331 LGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGI---SR 387
G + P + + F+ ++F++L G S++ + L +D I R
Sbjct: 329 -GLVFILYPEAISTL-SGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFHILKQHR 386
Query: 388 KTGTWIVFIIYFLLGIPVVYING--YLDQVDAWISFQLALLALFDIIVGV-WLFKPDNFW 444
K T+ V FLL + + G L +D + + L A+ +G+ W + D F
Sbjct: 387 KLFTFGVSFGTFLLALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGISWFYGVDRFS 446
Query: 445 KELHEGALINVPEFYKWITVIIAPIFIAL----------PLFGTFTD----LVSKTLGWP 490
+++ + +++ ++P F+ PL T+ D L + +GW
Sbjct: 447 EDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVIVSIINFKPL--TYDDYTFPLWANRIGW- 503
Query: 491 AKIAIIAMLIIGA 503
IA+ +ML++ A
Sbjct: 504 -GIALSSMLLVPA 515
>pir||S46260 creatine transporter - marbled electric ray
>gi|541754|emb|CAA54512.1| (X77306) creatine transporter
[Torpedo marmorata]
Length = 611
Score = 83.1 bits (202), Expect = 7e-15
Identities = 103/507 (20%), Positives = 194/507 (37%), Gaps = 84/507 (16%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R W+ ++ I++ G A+GLGN RFP NGGG F++PY L GIP+ ++E
Sbjct: 36 RVTWSRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLVAVFGGIPIFFLEIS 95
Query: 71 QGRY--GGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
G++ G + P F + S+ ++F N+YY+ ++ W
Sbjct: 96 LGQFMKAGGINAWNIAPLFKGLGYASM----VIVF-------------FCNTYYILVLTW 138
Query: 129 SAAY----------------SWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLL 172
S+ Y +W + + ++ + + + FW V+ L
Sbjct: 139 SSFYLVQSFSSPLPWASCNNTWNTAACYEAGANASTEIYPPTAPAQSSIVQFWERRVLRL 198
Query: 173 AIAVGQGVSKGIE-----------------RWVKVMMPLLYV---FAVILVIYVFALGSP 212
+ +G G E + VK ++YV F I+++ + G
Sbjct: 199 SSGLGDVGEIGWELTLCLTATWMLVYFCIWKGVKTSGKVVYVTATFPYIILVILLVRGVT 258
Query: 213 LGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKD 272
L ++G + P+W L E V + A QIFF+ ++G+G + SY +
Sbjct: 259 L----HGAVQGIVYYLQPDWGKLGEA--QVWIDAGTQIFFSYAIGLGTLTALGSYNQLHN 312
Query: 273 DVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLG 332
D +N G + L + V V+A+ G G
Sbjct: 313 DCYKDAFILSLVNSATSFFAGLVVFSILGFMAVEEGVDISVVAES------------GPG 360
Query: 333 FSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLE-----EDLGIS 386
++ + P V + + + L+F++L G S + + ++TA+L+
Sbjct: 361 LAFIAYPKA-VTLMPFPQVWAVLFFIMLLCLGLGSQFVGVEGFVTAILDLWPSKFSFRYL 419
Query: 387 RKTGTWIVFIIYFLLGIPVVYING-YLDQVDAWISFQ---LALLALFDIIVGVWLFKPDN 442
R+ +V + FL+ + ++ G Y+ Q+ + S L A ++ + W++ D
Sbjct: 420 REVVVAMVICLSFLIDLSMITEGGMYIFQIFDYYSASGTTLLWTAFWECVAVAWVYGGDR 479
Query: 443 FWKELHEGALINVPEFYKWITVIIAPI 469
+ +L KW +I P+
Sbjct: 480 YLDDLAWMLGYRPWALVKWCWSVITPL 506
>pir||T20052 hypothetical protein C49C3.1 - Caenorhabditis elegans
>gi|3875071|emb|CAB05153.1| (Z82264) predicted using
Genefinder~contains similarity to Pfam domain: PF00209
(Sodium:neurotransmitter symporter family), Score=403.1,
E-value=8.9e-118, N=2~cDNA EST yk7b9.5 comes from this
gene~cDNA EST yk7b9.3 comes from this gene~cDNA EST
yk133e6.>
Length = 706
Score = 82.3 bits (200), Expect = 1e-14
Identities = 43/122 (35%), Positives = 68/122 (55%), Gaps = 14/122 (11%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R W +I +L+ G A+GLGN RFPT+ NGG AF+VPY L G+P +++E++
Sbjct: 44 RGAWGNQIEFLLSTLGMAVGLGNIWRFPTRAYNNGGSAFLVPYVACALLFGLPAVYLEFL 103
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
G+Y H T P + + + ++ G+ G +A A ++L+ YY+ +IGWS
Sbjct: 104 LGQY-----HRTTAPIIF-------RRFAPILQGV--GWMAVAVSSLVAIYYIIIIGWST 149
Query: 131 AY 132
Y
Sbjct: 150 VY 151
>gi|11436405 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 [Homo sapiens]
Length = 733
Score = 81.9 bits (199), Expect = 2e-14
Identities = 74/299 (24%), Positives = 128/299 (42%), Gaps = 60/299 (20%)
Query: 7 QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
Q++ R +W K+ +L++AG IGLGN RFP NGGGAF +PYF+ F+ GIPV +
Sbjct: 52 QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFF 111
Query: 67 VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
+E G+Y + + A + P L G+ G + + LN YY+ ++
Sbjct: 112 LEVALGQYTSQGS---------VTAWRKICP---LFQGI--GLASVVIESYLNVYYIIIL 157
Query: 127 GWSAAYSWFSISGA--------YFNVESTAKF-----------FESYLSN---------- 157
W+ Y + S + ++N E F FE++ S
Sbjct: 158 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVL 217
Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFA 208
H L L W + + LL + + KG++ KV+ + + +++++ +
Sbjct: 218 GITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRG 277
Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASY 267
+ P +G + P+ LK+ V + A QIFF+ ++ G + SY
Sbjct: 278 VTLP------GAYQGIIYYLKPDLFRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSY 328
>gi|11436403 solute carrier family 6 (neurotransmitter transporter, GABA),
member 13 [Homo sapiens]
Length = 574
Score = 81.5 bits (198), Expect = 2e-14
Identities = 112/481 (23%), Positives = 202/481 (41%), Gaps = 94/481 (19%)
Query: 17 KIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYGG 76
K+ +L++AG IGLGN RFP NGGGAF +PY + LF GIPV +E G+Y
Sbjct: 20 KMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTS 79
Query: 77 KYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWFS 136
+ G + A + P IF IG A + LLN YY+ ++ W+ Y + S
Sbjct: 80 QGG---------VTAWRKICP----IFEGIGYA-SQMIVILLNVYYIIVLAWALFYLFSS 125
Query: 137 IS------GAY--FNVESTAKFFESYLSNHGL-------VFLFW---------------- 165
+ G Y +N E +F ++ S +G V FW
Sbjct: 126 FTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGA 185
Query: 166 -----GITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWS 219
+ ++L + + KG++ KV+ + + +++V+ + + P
Sbjct: 186 LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLP------G 239
Query: 220 TIKGFEFIWSPNWTYLKEHLW--SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALS 277
+G +F PN T LW V + A QIFF+ ++ +G + SY + S
Sbjct: 240 AAQGIQFYLYPNLT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGSY-NKYHNNCYS 294
Query: 278 GLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTS 337
G + V+ G +I L + VP +A+ G G ++ +
Sbjct: 295 GTSFVA---------GFAIFSILGFMSQEQGVPISEVAES------------GPGLAFIA 333
Query: 338 LPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFI- 396
P V + + + +F+++ + + + + +TAL++ + RK V I
Sbjct: 334 YPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLIL 393
Query: 397 ----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFKPDNFWKELH 448
+ FL+G+ ++ G Y+ Q+ D + + + LL A+F+ + W++ F+ +
Sbjct: 394 GVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIE 453
Query: 449 E 449
+
Sbjct: 454 D 454
>emb|CAB60372.1| (AL110485) contains similarity to Pfam domain: PF00209
(Sodium:neurotransmitter symporter family), Score=325.2,
E-value=2.4e-94, N=2~cDNA EST yk129c9.5 comes from this
gene; cDNA EST yk144g8.5 comes from this gene~cDNA EST
yk161h5.5 comes from this gen>
Length = 714
Score = 81.1 bits (197), Expect = 3e-14
Identities = 103/463 (22%), Positives = 178/463 (38%), Gaps = 116/463 (25%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
E+RD + +L G A+GLGN RFPT+ NGG AF++PY FL G+P ++ E
Sbjct: 70 EKRDGFGNSFEFVLTSLGLAVGLGNIWRFPTRAYNNGGSAFLIPYLTCAFLFGLPAVYFE 129
Query: 69 WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
++ G+Y GK P + R L+ G+ G + L+ YY+ ++ W
Sbjct: 130 FLTGQYQGK-----SPPVIFRRVRPILE-------GV--GWMGVFVAALVAIYYIVIVSW 175
Query: 129 SAAYS----------WFSISGAYFNVESTAKFFESYL-SNHGLVF---LFWGITVVL--- 171
+ Y W + + N S + YL NH V W ++ +
Sbjct: 176 ISIYMINICRGHFALWSHCNNDWNNGTSCITMADQYLCKNHTKVMANSTLWNSSLPIPDK 235
Query: 172 -------LAIAVGQGVSKGIERW------------------------------------- 187
A G VS E++
Sbjct: 236 MVYFNGACQDANGTDVSTATEQYFMTYIVQPSSGMLDFGGFNWPVFAAMSVCWLLTGLGI 295
Query: 188 ---VKVMMPLLYV-----FAVILVIY---VFALGSPLGQPQWSTIKGFEFIWSPNWTYLK 236
K+M + YV + +++V++ VF GS +G + +PN+T L
Sbjct: 296 LKGAKIMGKISYVSVLVPYVLVVVLFINGVFQDGSGVGLEM--------YFGTPNYTKLY 347
Query: 237 EH-LWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGS 295
E W+ L Q+ F+LS+G G + + +SY ++++ L + + +V GG+
Sbjct: 348 EQDTWTEALK---QLCFSLSVGHGGLISLSSYSPKRNNIFRDALIVIIGDTTMSLVGGGA 404
Query: 296 IAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGAL 355
+ L Y K V V + GL ++ P +M + +
Sbjct: 405 VFATL--GYLAKDVKDVVKS--------------GLSLAFVVYPEAMTRMPVPW-LWCFI 447
Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIY 398
+FL+L+ G ++ IA+ + + + + R WIV I +
Sbjct: 448 FFLMLFLLGASTEIALVDVFCSCIYDQYPRFRNR-KWIVVIAW 489
>gb|AAF70819.1|AF141930_1 (AF141930) high affinity GABA transporter [Trichoplusia ni]
Length = 608
Score = 80.8 bits (196), Expect = 4e-14
Identities = 48/130 (36%), Positives = 69/130 (52%), Gaps = 15/130 (11%)
Query: 8 MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
+ +R W +K+ IL++ G AIGLGN RFP NGGGAF++PYFL LFL GIP+ ++
Sbjct: 32 LPERGSWGSKLDFILSVIGLAIGLGNVWRFPYLCYKNGGGAFLIPYFLTLFLAGIPMFFM 91
Query: 68 EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
E G+ G G + A IF IG A A + +N YY+ ++
Sbjct: 92 ELAMGQMLTIGGLGVF--------------KIAPIFKGIGYAAA-VMSCWMNVYYIVILA 136
Query: 128 WSAAYSWFSI 137
W+ Y + S+
Sbjct: 137 WAIFYFFMSM 146
>gi|7705539 solute carrier family 6 (neurotransmitter transporter, GABA),
member 13; GABA transport protein [Homo sapiens]
>gi|7579920|gb|AAF64247.1| (U76343) GABA transport
protein [Homo sapiens]
Length = 569
Score = 78.8 bits (191), Expect = 1e-13
Identities = 111/481 (23%), Positives = 201/481 (41%), Gaps = 94/481 (19%)
Query: 17 KIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYGG 76
K+ +L++AG IGLGN RFP NGGGAF +PY + LF GIPV +E G+Y
Sbjct: 20 KMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTS 79
Query: 77 KYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWFS 136
+ G + A + P IF IG A + LLN YY+ ++ W+ Y + S
Sbjct: 80 QGG---------VTAWRKICP----IFEGIGYA-SQMIVILLNVYYIIVLAWALFYLFSS 125
Query: 137 IS------GAY--FNVESTAKFFESYLSNHGL-------VFLFW---------------- 165
+ G Y +N E +F ++ S +G V FW
Sbjct: 126 FTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGA 185
Query: 166 -----GITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWS 219
+ ++L + + KG++ KV+ + + +++V+ + + P
Sbjct: 186 LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLP------G 239
Query: 220 TIKGFEFIWSPNWTYLKEHLW--SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALS 277
+G +F PN T LW V + A QIFF+ ++ +G + SY + S
Sbjct: 240 AAQGIQFYLYPNLT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGSY-NKYHNNCYS 294
Query: 278 GLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTS 337
G + V+ G +I L + VP +A+ G G ++ +
Sbjct: 295 GTSFVA---------GFAIFSILGFMSQEQGVPISEVAES------------GPGLAFIA 333
Query: 338 LPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFI- 396
P V + + + +F+++ + + + + +TAL++ + RK V I
Sbjct: 334 YPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLIL 393
Query: 397 ----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFKPDNFWKELH 448
+ F +G+ ++ G Y+ Q+ D + + + LL A+F+ + W++ F+ +
Sbjct: 394 GVSVVSFPVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIE 453
Query: 449 E 449
+
Sbjct: 454 D 454
>emb|CAB42788.1| (AL034411) dJ808P6.1 (novel Sodium:neurotransmitter symporter
family protein) [Homo sapiens]
Length = 245
Score = 75.7 bits (183), Expect = 1e-12
Identities = 56/199 (28%), Positives = 98/199 (49%), Gaps = 17/199 (8%)
Query: 9 EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
+ R W+ K +L+M G A+GLGN RFP NGGGAF++PY + L L G+P+ ++E
Sbjct: 34 QDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLE 93
Query: 69 WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
G++ +LGP S+ L G+ G + + YY +I +
Sbjct: 94 CSLGQF------ASLGPV-------SVWRILPLFQGV--GITMVLISIFVTIYYNVIIAY 138
Query: 129 SAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWV 188
S Y + S + ++ A S ++ G++ + + ++L + VG + KGI+
Sbjct: 139 SLYYMFASFQ-SELPWKNLALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSG 197
Query: 189 KVM-MPLLYVFAVILVIYV 206
KV+ L+ + V+L++ V
Sbjct: 198 KVVYFTALFPYVVLLILLV 216
>gb|AAF59549.1| (AC024812) contains similarity to SW:NTSE_DROME [Caenorhabditis
elegans]
Length = 645
Score = 74.5 bits (180), Expect = 3e-12
Identities = 76/303 (25%), Positives = 130/303 (42%), Gaps = 73/303 (24%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
RDKWATK+ +LA+ G A+ LGN RFP+ +GGGAF++PYF+ L + G+P+ ++E V
Sbjct: 75 RDKWATKMEFLLAVVGYAVDLGNIWRFPSVCYKHGGGAFLIPYFIMLMIGGLPMFYMELV 134
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALA--------FATTTLLNSYY 122
G+ F+ S+ + +F IG + F + + Y
Sbjct: 135 LGQ-------------FHRSGCVSIWRKVCPLFRGIGYGICCICTFIAIFYNAIIAQAVY 181
Query: 123 LHLIG----WSAAYSWFSISGAYFNVESTAKFFESYLSNHGL--------VFLF------ 164
++ W + W S G +N + +S +G +L+
Sbjct: 182 FAIVSLSKIWDSEVPWAS-CGNPWNTPRCSDDLNVTISRNGTPLTTPSEEYYLYKVLEVQ 240
Query: 165 ------------WGITVVLLAI------AVGQG-VSKGIERWVKVMMPLLYVFAVILVIY 205
+ V LLA+ A+ +G S G WV P + + +++L+
Sbjct: 241 KSTGFDDLGGVKTSMAVCLLAVFIMVYFALWKGPQSSGKIVWVTATAPYI-ILSILLIRG 299
Query: 206 VFALGSPLGQPQWSTIKGFEFIWSPNWTYLKE-HLWSVMLAASGQIFFTLSLGMGIIQNY 264
+ G+ G + +P++ LK+ +WS AA+ QIFF+L G G++
Sbjct: 300 LLLPGAK---------NGLYYYVTPDFEKLKDPAVWS---AAATQIFFSLGPGFGVLLAL 347
Query: 265 ASY 267
+SY
Sbjct: 348 SSY 350
>gi|11181770 X transporter protein 3 [Homo sapiens] >gi|8980368|emb|CAB96872.1|
(AJ289880) orphan transporter XT3 [Homo sapiens]
>gi|9408102|emb|CAB99310.1| (AJ276207) orphan
transporter XT3 [Homo sapiens]
Length = 592
Score = 73.0 bits (176), Expect = 8e-12
Identities = 71/308 (23%), Positives = 123/308 (39%), Gaps = 52/308 (16%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R WA + + A A+GLGN RFP GGG+F+VPY + L + G+P++++E
Sbjct: 5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
G+ + G++G A ++ P + + G + + L+ YY + W+
Sbjct: 65 VGQ---RMRQGSIG------AWRTISPYLSGV-----GVASVVVSFFLSMYYNVINAWAF 110
Query: 131 AYSWFSI--------------------------SGAYFNVESTAKFFESYLSNHGLVFLF 164
Y + S S YF T S N G+
Sbjct: 111 WYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQ--- 167
Query: 165 W--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIK 222
W + ++L + V + +G E KV+ + +L+IY+ G
Sbjct: 168 WEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIR-----GLTLHGATN 222
Query: 223 GFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATV 282
G ++++P L + A+ QIFF+L LG G + +ASY P ++ +
Sbjct: 223 GLMYMFTPKIEQLANP--KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 280
Query: 283 SLNEFAEV 290
+N F +
Sbjct: 281 LINSFTSI 288
>gi|6756031 X transporter protein 3 [Mus musculus] >gi|3347920|gb|AAC27756.1|
(AF075261) orphan transporter [Mus musculus]
Length = 635
Score = 71.0 bits (171), Expect = 3e-11
Identities = 77/311 (24%), Positives = 126/311 (39%), Gaps = 55/311 (17%)
Query: 4 GVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIP 63
GV++ + R KW + +L A+GLGN RFP GGG+F+VPY + L + G+P
Sbjct: 42 GVVE-KVRPKWDNPLQFLLVCISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMP 100
Query: 64 VMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYL 123
++++E G+ + G++G A ++ P L G +A + L S Y
Sbjct: 101 LLYLELAVGQ---RMRXGSIG------AWRTISPY------LSGVGIASLVVSFLASVYF 145
Query: 124 HLIG-WSAAYSWFSI--------------------------SGAYFNVESTAKFFESYLS 156
++I W+ Y + S S YF T S
Sbjct: 146 NVINTWALWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQE 205
Query: 157 NHGLVFLFW--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
N G+ W + + L + V + +G E KV+ + +L+IY+ G
Sbjct: 206 NGGVQ---WEPALCLTLAWLMVYLCILRGTESTGKVVYFTTSLPYFVLIIYLVR-----G 257
Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
G ++++P L + A+ QIFF+L LG G + +ASY P +D
Sbjct: 258 LTLHGATNGLAYMFTPKIEQLANP--KAWINAATQIFFSLGLGCGGLIAFASYNEPSNDC 315
Query: 275 ALSGLATVSLN 285
L +N
Sbjct: 316 QKHALIVSVIN 326
>pir||S50998 transporter protein (clone rB21a) - rat >gi|914028|gb|AAB32806.1|
(S76742) neurotransmitter transporter rB21a [rats,
brain, Peptide, 616 aa] [Rattus sp.]
Length = 616
Score = 69.9 bits (168), Expect = 7e-11
Identities = 73/313 (23%), Positives = 124/313 (39%), Gaps = 56/313 (17%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R +W + + A A+GLGN RFP GGG+F+VPY + L + G+P++++E
Sbjct: 29 RPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEGMPLLYLELA 88
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
G+ + G++G A ++ P + + G + + L+ YY + W
Sbjct: 89 VGQ---RMRQGSIG------AWRTISPYLSGV-----GVASVVVSFFLSMYYNVINAWGF 134
Query: 131 AYSWFSI--------------------------SGAYFNVESTAKFFESYLSNHGLVFLF 164
Y + S S YF T S N G+
Sbjct: 135 WYLFHSFQDPLPWSVCPLNSNRTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQ--- 191
Query: 165 W--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIK 222
W + + L + V + +G E KV+ + +L+IY+ G
Sbjct: 192 WEPALCLTLAWLMVYLCILRGTESTGKVVYFTALMPYCVLIIYLVR-----GLTLHGATN 246
Query: 223 GFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD----VALSG 278
G ++++P L + A+ QIFF+L LG G + +ASY P +D +
Sbjct: 247 GLMYMFTPKIEQLANP--KAWINAATQIFFSLGLGFGSLIAFASYNEPSNDCQKHAVIVS 304
Query: 279 LATVSLNEFAEVV 291
+ S + FA +V
Sbjct: 305 VINSSTSIFASIV 317
>gb|AAC27755.1| (AF075260) orphan transporter [Homo sapiens]
Length = 315
Score = 69.5 bits (167), Expect = 9e-11
Identities = 70/308 (22%), Positives = 122/308 (38%), Gaps = 52/308 (16%)
Query: 11 RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
R WA + + A A+GLGN R P GGG+F+VPY + L + G+P++++E
Sbjct: 5 RPLWANSLQFVFACISYAVGLGNVWRNPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64
Query: 71 QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
G+ + G++G A ++ P + + G + + L+ YY + W+
Sbjct: 65 VGQ---RMRQGSIG------AWRTISPYLSGV-----GVASVVVSFFLSMYYNVINAWAF 110
Query: 131 AYSWFSI--------------------------SGAYFNVESTAKFFESYLSNHGLVFLF 164
Y + S S YF T S N G+
Sbjct: 111 WYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQ--- 167
Query: 165 W--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIK 222
W + ++L + V + +G E KV+ + +L+IY+ G
Sbjct: 168 WEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIR-----GLTVHGATN 222
Query: 223 GFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATV 282
G ++++P L + A+ QIFF+L LG G + +ASY P ++ +
Sbjct: 223 GLMYMFTPKIEQLANP--KAWINAATQIFFSLXLGFGSLIAFASYNEPSNNCQKHAIIVS 280
Query: 283 SLNEFAEV 290
+N F +
Sbjct: 281 LINSFTSI 288
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.326 0.143 0.454
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 209026083
Number of Sequences: 2977
Number of extensions: 9456337
Number of successful extensions: 30940
Number of sequences better than 1.0e-10: 119
Number of HSP's better than 0.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 30539
Number of HSP's gapped (non-prelim): 168
length of query: 527
length of database: 189,106,746
effective HSP length: 50
effective length of query: 477
effective length of database: 159,182,396
effective search space: 75930002892
effective search space used: 75930002892
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.6 bits)
S2: 167 (69.5 bits)