BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB1850 (PAB1850) DE:sodium- and chloride-dependent transporter
         (527 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||A75122 sodium- and chloride-dependent transporter PAB1850 -...  1074  0.0
pir||F71009 probable sodium-dependent transporter - Pyrococcus h...  1009  0.0
pir||B70478 probable sodium symporter snf [similarity] - Aquifex...   333  2e-90
sp|Q58715|YD19_METJA HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER M...   190  4e-47
gi|11499577 sodium- and chloride-dependent transporter [Archaeog...   188  1e-46
gb|AAG19815.1| (AE005066) daunorubicin resistance ABC transporte...   178  1e-43
pir||E82127 sodium-dependent transporter VC2012 [imported] - Vib...   177  2e-43
sp|P44849|Y736_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER H...   176  4e-43
dbj|BAB04847.1| (AP001511) sodium-dependent transporter [Bacillu...   169  5e-41
pir||G82096 sodium-dependent transporter VC2283 [imported] - Vib...   166  8e-40
pir||B82171 probable sodium-dependent transporter VC1669 [import...   161  2e-38
pir||E81964 probable sodium-dependent inner membrane transport p...   156  7e-37
pir||H81019 sodium- and chloride-dependent transporter NMB1975 [...   156  7e-37
pir||F81050 sodium- and chloride-dependent transporter NMB1707 [...   155  1e-36
pir||G81824 probable integral membrane ion transporter NMA1961 [...   154  2e-36
gb|AAG19816.1| (AE005066) sodium- and chloride-dependent transpo...   152  8e-36
pir||T46663 probable sodium/chloride ion channel [imported] - Ne...   152  1e-35
pir||D69902 sodium-dependent transporter homolog yocR - Bacillus...   150  3e-35
pir||F69825 sodium-dependent transporter homolog yhdH - Bacillus...   150  4e-35
dbj|BAB03936.1| (AP001507) sodium-dependent transporter [Bacillu...   148  1e-34
dbj|BAB07158.1| (AP001518) sodium-dependent transporter [Bacillu...   148  1e-34
pir||F81367 probable transmembrane transport protein Cj0935c [im...   145  2e-33
pir||G71930 probable transporter - Helicobacter pylori (strain J...   140  4e-32
sp|P45320|YG90_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER H...   140  4e-32
pir||B64582 sodium- and chloride-dependent transporter - Helicob...   138  1e-31
pir||E81367 probable transmembrane transport protein Cj0934c [im...   136  5e-31
dbj|BAA24689.1| (AB010832) putative tryptophan tranporter; simil...   131  3e-29
pir||H81407 probable sodium-dependent transmembrane transport pr...   130  4e-29
gb|AAF73566.1| (AE002319) sodium-dependent transporter, putative...   123  6e-27
gb|AAC46377.1| (AF017105) sodium-dependent transporter [Chlamydo...   121  2e-26
pir||C71541 probable na-dependent transporter - Chlamydia tracho...   121  2e-26
pir||F72095 na-dependent transporter - Chlamydophila pneumoniae ...   120  4e-26
gb|AAF73672.1| (AE002208) sodium-dependent transporter, putative...   120  4e-26
dbj|BAA89537.1| (AB006986) taurine transporter [Cyprinus carpio]      119  9e-26
pir||A64582 sodium- and chloride-dependent transporter - Helicob...   117  4e-25
dbj|BAB18038.1| (AB033497) taurine transporter [Tilapia mossambica]   114  3e-24
gi|6678223 taurine/beta-alanine transporter [Mus musculus] >gi|6...   114  3e-24
pir||F71930 probable transporter - Helicobacter pylori (strain J...   114  3e-24
gi|8394318 taurine/beta-alanine transporter [Rattus norvegicus] ...   113  4e-24
sp|O35316|NTTA_MOUSE SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND ...   113  7e-24
gb|AAF76147.1|AF260239_1 (AF260239) taurine transporter [Bos tau...   111  2e-23
gb|AAF57986.1| (AE003806) DAT gene product [Drosophila melanogas...   111  2e-23
pir||S46487 taurine transporter - human >gi|559853|gb|AAA50842.1...   110  3e-23
gi|11433499 solute carrier family 6 (neurotransmitter transporte...   110  3e-23
sp|P31641|NTTA_HUMAN SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRAN...   110  3e-23
gi|4507045 solute carrier family 6 (neurotransmitter transporter...   110  5e-23
sp|P31652|NTSE_RAT SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT T...   109  6e-23
pir||S19585 serotonin transport protein - rat >gi|228225|prf||17...   109  6e-23
pir||A47194 taurine and beta-alanine transporter, TAUT - mouse        109  8e-23
sp|P31642|NTTA_MUSCO SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND ...   109  8e-23
sp|Q00589|NTTA_CANFA SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRAN...   109  1e-22
pir||A46270 Na and Cl dependent taurine transporter - dog             109  1e-22
sp|Q60857|NTSE_MOUSE SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT...   108  1e-22
gb|AAD26262.1|AF119122_1 (AF119122) serotonin transporter [Bos t...   108  1e-22
gi|8394200 GABA transporter [Rattus norvegicus] >gi|881598|gb|AA...   108  2e-22
sp|P48056|NTBE_RAT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSP...   108  2e-22
gi|7110639 5-hydroxytryptamine (serotonin) transporter [Mus musc...   107  3e-22
pir||S63539 GABA/beta-alanine transporter - marbled electric ray...   106  9e-22
sp|P31651|NTBE_MOUSE SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRAN...   105  2e-21
gi|6981554 solute carrier family 6 (neurotransmitter transporter...   105  2e-21
gb|AAC05185.1| (AF049108) GABA transporter [Raja sp.]                 104  2e-21
gb|AAF97247.1|AF285761_1 (AF285761) serotonin transporter [Macac...   104  2e-21
gi|4507039 solute carrier family 6 (neurotransmitter transporter...   104  3e-21
sp|O35899|NTSE_CAVPO SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT...   104  3e-21
sp|P23978|NTG1_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORT...   104  3e-21
sp|P48057|NTG1_MUSCO SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO...   103  4e-21
pir||S65673 GABA transport protein - tobacco hornworm >gi|695378...   103  6e-21
pir||S68236 betaine/GABA transport protein BGT-1 - human >gi|881...   102  8e-21
gi|4507037 solute carrier family 6 (neurotransmitter transporter...   102  8e-21
gb|AAG01287.1|AF246893_1 (AF246893) serotonin transporter [Ovis ...   101  2e-20
sp|P31646|NTG2_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORT...   101  3e-20
sp|P48055|NTBE_RABIT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRAN...   101  3e-20
sp|P31648|NTG1_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO...   100  4e-20
pir||I51368 gamma-aminobutyric acid transport protein GAT-1 - Pa...    99  9e-20
gb|AAG20907.1| (AE005157) sodium-dependent transporter; YocR [Ha...    99  9e-20
gi|4507043 solute carrier family 6 (neurotransmitter transporter...    99  1e-19
gi|7657587 solute carrier family 6 (neurotransmitter transporter...    99  1e-19
gi|11428196 solute carrier family 6 (neurotransmitter transporte...    99  1e-19
sp|P27799|NTBE_CANFA SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRAN...    98  3e-19
gb|AAF21642.1|AF032873_1 (AF032873) inebriated protein [Manduca ...    98  3e-19
sp|P31649|NTG3_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO...    97  4e-19
pir||I56506 Na+/Cl(-)-dependent neurotransmitter transporter, br...    96  8e-19
sp|P31662|NTT4_RAT SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER NT...    96  1e-18
pir||C71376 probable sodium- and chloride- dependent transporter...    95  2e-18
gb|AAD10615.1| (U02296) cocaine-sensitive serotonin transporter ...    94  4e-18
sp|P51905|NTSE_DROME SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT...    94  4e-18
pir||JH0674 L-proline transport protein - rat                          93  9e-18
sp|P28573|NTPR_RAT SODIUM-DEPENDENT PROLINE TRANSPORTER >gi|2052...    93  9e-18
sp|P31647|NTG3_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORT...    93  9e-18
sp|P31650|NTG4_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPO...    90  4e-17
gi|7657589 solute carrier family 6 (neurotransmitter transporter...    90  4e-17
gi|11416778 solute carrier family 6 (neurotransmitter transporte...    90  4e-17
gi|11434830 solute carrier family 6 (neurotransmitter transporte...    90  6e-17
gb|AAF45873.2| (AE003427) CG10804 gene product [Drosophila melan...    89  1e-16
gb|AAC47292.1| (U66460) inebriated [Drosophila melanogaster]           89  1e-16
emb|CAA69649.1| (Y08362) neurotransmitter transporter [Drosophil...    89  1e-16
gb|AAF51001.1| (AE003576) ine gene product [Drosophila melanogas...    89  1e-16
gi|8394204 X transporter protein 2 [Rattus norvegicus] >gi|53146...    89  1e-16
gb|AAF98299.1|AF237673_1 (AF237673) norepinephrine transporter [...    89  2e-16
gb|AAC27757.1| (AF075262) orphan transporter isoform A12 [Mus mu...    88  3e-16
gb|AAC27758.1| (AF075263) orphan transporter isoform A11 [Mus mu...    88  3e-16
gb|AAC27759.1| (AF075264) orphan transporter isoform B11 [Mus mu...    88  3e-16
gb|AAC27760.1| (AF075265) orphan transporter isoform A10 [Mus mu...    88  3e-16
gb|AAC27761.1| (AF075266) orphan transporter isoform B9 [Mus mus...    88  3e-16
gi|6756029 X transporter protein 2 [Mus musculus] >gi|3347932|gb...    88  3e-16
gb|AAF89166.1|AF230787_1 (AF230787) norepinephrine transporter [...    87  6e-16
pir||S46260 creatine transporter - marbled electric ray >gi|5417...    83  7e-15
pir||T20052 hypothetical protein C49C3.1 - Caenorhabditis elegan...    82  1e-14
gi|11436405 solute carrier family 6 (neurotransmitter transporte...    82  2e-14
gi|11436403 solute carrier family 6 (neurotransmitter transporte...    82  2e-14
emb|CAB60372.1| (AL110485) contains similarity to Pfam domain: P...    81  3e-14
gb|AAF70819.1|AF141930_1 (AF141930) high affinity GABA transport...    81  4e-14
gi|7705539 solute carrier family 6 (neurotransmitter transporter...    79  1e-13
emb|CAB42788.1| (AL034411) dJ808P6.1 (novel Sodium:neurotransmit...    76  1e-12
gb|AAF59549.1| (AC024812) contains similarity to SW:NTSE_DROME [...    75  3e-12
gi|11181770 X transporter protein 3 [Homo sapiens] >gi|8980368|e...    73  8e-12
gi|6756031 X transporter protein 3 [Mus musculus] >gi|3347920|gb...    71  3e-11
pir||S50998 transporter protein (clone rB21a) - rat >gi|914028|g...    70  7e-11
gb|AAC27755.1| (AF075260) orphan transporter [Homo sapiens]            69  9e-11

>pir||A75122 sodium- and chloride-dependent transporter PAB1850 - Pyrococcus
           abyssi (strain Orsay) >gi|5458201|emb|CAB49690.1|
           (AJ248285) sodium-and chloride-dependent transporter
           [Pyrococcus abyssi]
           Length = 527
           
 Score = 1074 bits (2747), Expect = 0.0
 Identities = 527/527 (100%), Positives = 527/527 (100%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL
Sbjct: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60

Query: 61  GIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNS 120
           GIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNS
Sbjct: 61  GIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNS 120

Query: 121 YYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGV 180
           YYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGV
Sbjct: 121 YYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGV 180

Query: 181 SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW 240
           SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW
Sbjct: 181 SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW 240

Query: 241 SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPL 300
           SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPL
Sbjct: 241 SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPL 300

Query: 301 AVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLL 360
           AVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLL
Sbjct: 301 AVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLL 360

Query: 361 WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS 420
           WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS
Sbjct: 361 WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS 420

Query: 421 FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFT 480
           FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFT
Sbjct: 421 FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFT 480

Query: 481 DLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL 527
           DLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL
Sbjct: 481 DLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL 527


>pir||F71009 probable sodium-dependent transporter - Pyrococcus horikoshii
           >gi|3257795|dbj|BAA30478.1| (AP000006) 521aa long
           hypothetical sodium-dependent transporter [Pyrococcus
           horikoshii]
           Length = 521
           
 Score = 1009 bits (2580), Expect = 0.0
 Identities = 490/522 (93%), Positives = 506/522 (96%), Gaps = 1/522 (0%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           + MEQR++WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM
Sbjct: 1   MDMEQRERWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 60

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSAL FGLIGGALAFATTTLLNSYYLHL
Sbjct: 61  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALWFGLIGGALAFATTTLLNSYYLHL 120

Query: 126 IGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIE 185
           IGWSAAYSWFSI+GAY+  ++TA+FF  YLSNHGLVFLFWGITVVLL IAVGQGVSKGIE
Sbjct: 121 IGWSAAYSWFSITGAYYG-KNTAQFFSQYLSNHGLVFLFWGITVVLLGIAVGQGVSKGIE 179

Query: 186 RWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLA 245
           RWVKVMMPLLYVFA+ILVIYVFALGSPLGQPQWSTIKGFEFIWSPNW YLK+HLW VMLA
Sbjct: 180 RWVKVMMPLLYVFAIILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWGYLKDHLWKVMLA 239

Query: 246 ASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYA 305
           ASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYA
Sbjct: 240 ASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYA 299

Query: 306 PKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGF 365
           PKIVPP+VLAKGS+AAL WISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGF
Sbjct: 300 PKIVPPDVLAKGSDAALAWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGF 359

Query: 366 TSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLAL 425
           TSAIAMYNYLTALLEEDLGI R  GTW+VFIIYFLLGIPVVYINGYLDQVDAWISFQLAL
Sbjct: 360 TSAIAMYNYLTALLEEDLGIKRSVGTWVVFIIYFLLGIPVVYINGYLDQVDAWISFQLAL 419

Query: 426 LALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSK 485
           LALFDIIV VWLFKPDNFW+ELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSK
Sbjct: 420 LALFDIIVSVWLFKPDNFWRELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSK 479

Query: 486 TLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEKNEVIIKL 527
           TLGWPAKIAI+ ML IGAIEAYYAIKKKYGEELEKNEVIIK+
Sbjct: 480 TLGWPAKIAILTMLTIGAIEAYYAIKKKYGEELEKNEVIIKV 521


>pir||B70478 probable sodium symporter snf [similarity] - Aquifex aeolicus
           >gi|2984293|gb|AAC07817.1| (AE000771)
           Na(+):neurotransmitter symporter (Snf family) [Aquifex
           aeolicus]
           Length = 513
           
 Score =  333 bits (846), Expect = 2e-90
 Identities = 199/536 (37%), Positives = 296/536 (55%), Gaps = 57/536 (10%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ WAT++GLILAMAGNA+GLGNF+RFP Q A NGGGAFM+PY +A  L+GIP+MW+EW
Sbjct: 4   KREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEW 63

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             GRYGG  GHGT    FYL+ R     R A I G+ G  +          YY+++  W+
Sbjct: 64  AMGRYGGAQGHGTTPAIFYLLWRN----RFAKILGVFGLWIPLVVAI----YYVYIESWT 115

Query: 130 AAYSWFSISGAY-------FNVESTAKFFESYLSNH--------------GLVFLFWGIT 168
             ++   + G          + +S  + F+ +L ++                 ++ + IT
Sbjct: 116 LGFAIKFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLIT 175

Query: 169 VVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIW 228
           + +    + +G+SKGIER+ K+ MP L++ AV LVI VF L +P G    +   G  F+W
Sbjct: 176 MFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNG----TAADGLNFLW 231

Query: 229 SPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFA 288
           +P++  LK+    V +AA GQIFFTLSLG G I  YASY+    D+ LSGL   +LNE A
Sbjct: 232 TPDFEKLKDP--GVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKA 289

Query: 289 EVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA 348
           EV+LGGSI++P AVA+        +   G+          F LGF   +LP IF Q    
Sbjct: 290 EVILGGSISIPAAVAFFGVANAVAIAKAGA----------FNLGF--ITLPAIFSQT-AG 336

Query: 349 GRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGT-WIVFIIYFLLGIPVVY 407
           G F G LWF LL+FAG TS+IA+   + A LE++L +SRK    W   I++F   + V++
Sbjct: 337 GTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHL-VMF 395

Query: 408 INGYLDQVDAWI-SFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVII 466
           +N  LD++D W  +  +    L ++I+  W+F  D  W+E++ G +I VP  Y ++   I
Sbjct: 396 LNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYI 455

Query: 467 APIFIALPLFGTFTDLVSKTLG------WPAKIAIIAMLIIGAIEAYYAIKKKYGE 516
            P F+A+ L     + + K +       W  +  II + +      + A +++  E
Sbjct: 456 TPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE 511


>sp|Q58715|YD19_METJA HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER MJ1319
           >gi|2129285|pir||F64464 sodium-dependent noradrenaline
           transporter homolog - Methanococcus jannaschii
           >gi|1591959|gb|AAB99329.1| (U67572) sodium-dependent
           transporter [Methanococcus jannaschii]
           Length = 492
           
 Score =  190 bits (477), Expect = 4e-47
 Identities = 142/512 (27%), Positives = 246/512 (47%), Gaps = 63/512 (12%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ W++ +G ILA  G+AIGLGN  RF   V  NGGGAF++PY +AL  +GIP+M +E+
Sbjct: 5   ERESWSSNLGFILASVGSAIGLGNIWRFGYMVYTNGGGAFLIPYIVALLCVGIPLMILEF 64

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G Y  K            +A E L   S        G  A  +  ++ SYY+ +I W 
Sbjct: 65  AIGHYTKKSAP---------LALEKLHKGSEWT-----GWFAVISGFIITSYYVVIIAWC 110

Query: 130 AAYSWFSISGAYFNVESTAKFFESYLS-----------NHGLV---FLFWGITVVLLAIA 175
             Y    +   Y + +  A FF + L            ++G++      WGI  ++L+  
Sbjct: 111 LYYLIILVIYGYPS-DPNAYFFHNILQISSGVEDIGGVSYGILVSTLAVWGIVALILS-- 167

Query: 176 VGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYL 235
              G+  G+E+  K+M+P L    ++LV+    L   L   +W     F  +++      
Sbjct: 168 --AGIKNGLEKANKIMIPFLLFLIILLVLNALTLPGALTGIEWYLTPDFSALFN------ 219

Query: 236 KEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGS 295
               ++V L+A  QIFF+LSLG GI+  YASYL  K D+ ++ +    LN     + G +
Sbjct: 220 ----YNVWLSAFSQIFFSLSLGFGILIAYASYLPKKSDLTINAVTVSLLNCGFSFLAGFA 275

Query: 296 IAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGAL 355
           +   L        +P +          + +SE  G+G ++ + P     +  A R FG +
Sbjct: 276 VFGTLGYMSYTSGIPLD----------KAVSE--GIGLAFVTFPKALSLLPFASRLFGIV 323

Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING----Y 411
           +FL L FAG +SA+++     + + +   +SRK     V  ++ +  I  ++  G    Y
Sbjct: 324 FFLALVFAGISSAVSIVEASVSAIIDKFSLSRKKALLAVLALFII--ISPIFTTGAGLYY 381

Query: 412 LDQVDAWIS-FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIF 470
           LD +D + S + L + A+ +II+ +WLF  D   + +++ + I +  ++K++  +++PI 
Sbjct: 382 LDIIDHFASGYLLPIAAILEIIIAIWLFGGDKLREHVNKLSEIKLGVWWKYLAGVVSPII 441

Query: 471 IALPLFGTFTD-LVSKTLGWPAKIAIIAMLII 501
           +   +F   ++ L S   G+     I   LII
Sbjct: 442 LTAVVFLDASNVLTSGYGGYKTTYVIFGALII 473


>gi|11499577 sodium- and chloride-dependent transporter [Archaeoglobus fulgidus]
           >gi|7441661|pir||B69499 sodium- and chloride-dependent
           transporter homolog - Archaeoglobus fulgidus
           >gi|2648543|gb|AAB89259.1| (AE000965) sodium- and
           chloride-dependent transporter [Archaeoglobus fulgidus]
           Length = 491
           
 Score =  188 bits (473), Expect = 1e-46
 Identities = 155/517 (29%), Positives = 258/517 (48%), Gaps = 60/517 (11%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ WAT+ G +LA  G+AIGLGN  RF   V  NGGGAF++PYF+ALF+ GI +M +E+
Sbjct: 4   ERENWATRAGFVLAAIGSAIGLGNIWRFGYLVYKNGGGAFLIPYFVALFVAGISLMILEF 63

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
                        +G  F   A  S++      F  IG   A     ++  YY  +IGW+
Sbjct: 64  ------------AIGHRFRGSAPASMRKLGGRGFEWIGW-WAVTGGLIITMYYTVVIGWA 110

Query: 130 AAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGI-TVVLLAIAV---------GQG 179
             Y   S++ A+   ++   FF + L      + F G  T VL+A  +          +G
Sbjct: 111 IVYFTKSLTLAW-GEDTGGYFFGTVLQLSDNPWDFGGFATEVLIATIIVWALNWLVDFRG 169

Query: 180 VSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHL 239
           + KGIE+   ++MPLL++ AVILVI    L           ++G E+   P+++ L +  
Sbjct: 170 IRKGIEKANLLLMPLLWLLAVILVIRAVTLP--------GAMEGIEWYLKPDFSKLGD-- 219

Query: 240 WSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVP 299
           +++ LAA GQIFFTLSLGMGI+  YASYL  K D+A +       N     ++G ++   
Sbjct: 220 YNIWLAAFGQIFFTLSLGMGIMIAYASYLPEKSDIANNAFIVSLANCAFSFLVGFAVFGT 279

Query: 300 LA-VAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFL 358
           L  +AYA +    +V+A+              +G ++   P     +     F  A++FL
Sbjct: 280 LGYMAYATQSDISDVVAQ-------------SVGLAFVVFPKALNMLPALKVFTAAVFFL 326

Query: 359 LLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING--YLDQVD 416
            L  AG +S+I++   +++ L +  G+ R+    IV ++ FL  I      G  +LD VD
Sbjct: 327 ALVVAGLSSSISLVEAVSSALMDKFGMERRKAVNIVVLVGFLGSIVYTTKAGLYWLDVVD 386

Query: 417 AWISFQ-LALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFY----KWITVIIAPIFI 471
            +I++  L L+ L ++I   WLF        ++  + I V  ++    K+ T +I  + +
Sbjct: 387 HFINYYGLVLVGLLEVIAAAWLFDLTVLKNHINSVSEIKVGMWWDLAVKFATPLILAVLL 446

Query: 472 ALPLFGTFTDLVSKTLGWPAKIAI--IAMLIIGAIEA 506
            L + G  T+      G+P ++ +  ++++++G I A
Sbjct: 447 ILDIRGNLTENYG---GYPTEVLLTGLSIIVLGMIVA 480


>gb|AAG19815.1| (AE005066) daunorubicin resistance ABC transporter ATP-binding
           protein; Trp6 [Halobacterium sp. NRC-1]
           Length = 447
           
 Score =  178 bits (448), Expect = 1e-43
 Identities = 142/476 (29%), Positives = 221/476 (45%), Gaps = 51/476 (10%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           M +R+ WA+++G ILA  G+A+GLGN  +FP + A  GG AF+V Y +A  LLG+P +  
Sbjct: 1   MAERETWASRLGFILAAVGSAVGLGNIWQFPFKTATEGGAAFVVVYLVAALLLGLPAILG 60

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           E+V GR               L A E+        + ++ GA+   T   + SYY  + G
Sbjct: 61  EFVIGRRAN------------LNAVEAFDRLDHPAWTIV-GAMGLLTGLWILSYYSVVGG 107

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
           W   Y   S +GAYF   + A +F S +S       F G  +   A  V  G+  GIE+ 
Sbjct: 108 WVTRYLLGSATGAYF--AAPAAYFGS-VSMGWEAVAFHGAFMAATAGIVAFGIEDGIEKA 164

Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKG----FEFIWSPNWTYLKEHLWSVM 243
            K+M+P + V  V L +Y             ST+ G    +EF  SP++ ++ +++ S++
Sbjct: 165 TKLMVPSILVMLVGLAVYA------------STLNGVGAAYEFYLSPDFGFIADNIGSIV 212

Query: 244 LAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVA 303
             A  Q FF+LSLGMG +  YASYLG  D +   G   V LN  +  +L G + +PL   
Sbjct: 213 PYAVSQAFFSLSLGMGAMITYASYLGDDDSLFADGGLIVVLNT-SVGLLAGLVVIPLLFV 271

Query: 304 YAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFA 363
               +  P+  A G            G G  + S+   F  +G AGR  G L+F ++  A
Sbjct: 272 QFGTV--PDAAAGG------------GAGALFISVAQAFATLGVAGRVLGVLFFGVVLVA 317

Query: 364 GFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAW-ISFQ 422
             +SAI++   +TA + ++ G SR    +    + F LG    +   +LD  D+      
Sbjct: 318 ALSSAISLLEVVTAYVVDNYGYSRPATAFSFGGVLFALGTLSAWNTAWLDWFDSLAYGVL 377

Query: 423 LALLALFDIIVGVWLFKP---DNFWKELHEGALINVPEFYKWITVIIAPIFIALPL 475
           L L  L  ++   W++ P   D   K    G        +   T ++  +F+ L L
Sbjct: 378 LPLSVLLGVVFVGWVYGPAAVDEIKKGSGTGTTFATAWLWSVRTYVLIGVFVTLYL 433


>pir||E82127 sodium-dependent transporter VC2012 [imported] - Vibrio cholerae
           (group O1 strain N16961) >gi|9656556|gb|AAF95160.1|
           (AE004276) sodium-dependent transporter [Vibrio
           cholerae]
           Length = 527
           
 Score =  177 bits (445), Expect = 2e-43
 Identities = 153/529 (28%), Positives = 253/529 (46%), Gaps = 68/529 (12%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R++W +++G +LA  G+AIGLGN  RFP     NGGGAF +PY  A+   GIP M +E+
Sbjct: 43  KREQWGSRVGFVLAAVGSAIGLGNIWRFPYMAYENGGGAFFIPYLFAMVTAGIPFMILEF 102

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+      H    PT         +       G+           ++  YY+ +IGW+
Sbjct: 103 SMGQ-----KHRGSAPTTLAKIHSKFEWLGWFQVGI---------AAVIAVYYVAVIGWA 148

Query: 130 AAYSWFSISGAYFNVESTAKFFESYL-----SNHGLVFLFWGITVVLLA------IAVGQ 178
            +Y   S + ++   ++ A FF  YL     S   L  + W I   +L        A+  
Sbjct: 149 ISYFGMSFTQSW-GSDTNAYFFSEYLKLGDNSPTNLGSIQWHIAFAMLIAWVITYAAIVG 207

Query: 179 GVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEH 238
           GV KGIER  K+MMP+L++  +IL+  +  L   L         G  +++ P+++     
Sbjct: 208 GVKKGIERASKIMMPILFIMVLILIARMIFLPGAL--------DGVNYMFQPDFS----K 255

Query: 239 LWSVML--AASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSI 296
           +W V +  AA GQIFFTLS+G  I+  Y+SYL  K D+  +   TV +N    V+ G  I
Sbjct: 256 IWDVKVWAAAYGQIFFTLSIGFAIMLAYSSYLPEKSDITNNAFMTVLINCGFSVLAG--I 313

Query: 297 AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALW 356
            +   + Y         +A+     L  +  + G+G ++ +LP   + +       G L+
Sbjct: 314 MIFSVLGY---------MAQEQGKPLTEV-VSAGVGLAFVTLP-AAINLLPIPYILGPLF 362

Query: 357 FLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING--YLDQ 414
           FL L  AG +S I++   +T+ L + LG SRK    IV  I FL+ +      G   LD 
Sbjct: 363 FLALVVAGLSSHISIMEAVTSALIDKLGWSRKKAANIVIGIGFLVSMAFATNGGLLLLDL 422

Query: 415 VDAWISFQLALLA--LFDIIVGVWLFKPDNFWKELHEGALINVPEFY----KWITVIIAP 468
           VD + +  + ++A  L ++++  WL K  +  K ++  +  +V  ++    ++++ +I  
Sbjct: 423 VDHFAN-NVGIMASCLVELVLMTWLLKISDVRKYVNSISDFSVGVWFDICLRFVSPVILA 481

Query: 469 IFIALPLFGTFTD---LVSKTLGWPAKIAIIAMLIIGAIEAYYAIKKKY 514
           I +A  L   FT+       TLGW     I A+L+IG +    + K+ Y
Sbjct: 482 IIVATKLQALFTEGYGGYDLTLGW---AIIAALLVIGILINASSRKEAY 527


>sp|P44849|Y736_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER HI0736
           >gi|1075315|pir||E64089 probable transport protein
           HI0736 - Haemophilus influenzae  (strain Rd KW20)
           >gi|1573742|gb|AAC22395.1| (U32757) sodium-dependent
           transporter, putative [Haemophilus influenzae Rd]
           Length = 508
           
 Score =  176 bits (443), Expect = 4e-43
 Identities = 144/518 (27%), Positives = 241/518 (45%), Gaps = 69/518 (13%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           ++R+ ++ +   ILA  G+A+GLGN  RFP     NGGGAF++PY +AL   GIP+++++
Sbjct: 9   QKRETFSGRRAFILAAIGSAVGLGNIWRFPYTTYENGGGAFIIPYLIALLTAGIPLLFLD 68

Query: 69  WVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           +  G   R G    +    P F +                  G        ++  YY  +
Sbjct: 69  YAIGHRHRGGAPLSYRRFSPHFEVF-----------------GWWQMMVNVIIGLYYAVV 111

Query: 126 IGWSAAYSWFSISGAYFNVE---STAKFFESYLSNHGLVFLFWG-ITVVLLA---IAVG- 177
           +GW+A+Y++FS +GA+ +        KF +     +G+ F F G +T  L+A   +A+G 
Sbjct: 112 LGWAASYTYFSFTGAWGDKPIDFFIGKFLKMGDIKNGISFEFVGMVTAPLIAMWIVALGV 171

Query: 178 --QGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYL 235
              GV KGI +   V+MP+L V  ++LVIY   L            KG + +++P+W+ L
Sbjct: 172 LSMGVQKGIAKVSSVLMPVLVVMFMVLVIYSLFLP--------GAAKGLDALFTPDWSKL 223

Query: 236 KEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGS 295
                SV +AA GQIFF+LS+G GI+  YASYL  + D+  SGL     N   EV+ G  
Sbjct: 224 SNP--SVWIAAYGQIFFSLSIGFGIMVTYASYLKKESDLTGSGLVVGFANSSFEVLAGIG 281

Query: 296 IAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGAL 355
           +   L      +      +AKG            G+G ++ + P I +     G   G L
Sbjct: 282 VFAALGFIATAQGQEVSEVAKG------------GIGLAFFAFPTI-INKAPFGEVLGML 328

Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQV 415
           +F  L FA  TS I++   + + +++ + ISR   T+IV +   L+ + +      L  +
Sbjct: 329 FFGSLTFAALTSFISVIEVIISAIQDKIRISRGKVTFIVGVPMMLVSVILFGTTTGLPML 388

Query: 416 DAWIS----FQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
           D +      F +  +A   +I  V   K       L+E +   V  F++ + +++    +
Sbjct: 389 DVFDKFVNYFGIVAVAFASLIAIVANEKLGLLGNHLNETSSFKVGFFWR-LCIVLTSGVL 447

Query: 472 ALPLFGTFTDLVSK-----------TLGWPAKIAIIAM 498
           A  LF     + S+           T GW   I+++ +
Sbjct: 448 AFMLFSEGAKVFSEGYEGYPNWFVNTFGWGMSISLLVV 485


>dbj|BAB04847.1| (AP001511) sodium-dependent transporter [Bacillus halodurans]
           Length = 453
           
 Score =  169 bits (425), Expect = 5e-41
 Identities = 133/413 (32%), Positives = 197/413 (47%), Gaps = 49/413 (11%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           Q   R++WA+++G ILA  G+A+GLGN  RF      NGG AF++ Y   + L+GIP++ 
Sbjct: 5   QQTGREQWASRLGFILAAMGSAVGLGNIWRFSYVTGENGGAAFLLVYLGFIALIGIPIVL 64

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKP-RSALIFGLIGGALAFATTTLLNSYYLHL 125
            E+  GR       G+          E L P +   + GL+G A  F    L+ S+Y  +
Sbjct: 65  AEFTIGRRAQSDAVGSF---------EKLAPGKPWKVAGLMGVAAGF----LILSFYGVI 111

Query: 126 IGWSAAYSWFSISGAYFN--VESTAKFFESYLSNHGLVFLFWGITVVLLAI-AVGQGVSK 182
            GW   Y +  I+G  ++   E    FFE +++N  L  LFW    ++  I  V  GV K
Sbjct: 112 AGWILFYLFNYITGQLWSAPAEGFGGFFEGFIANPTLP-LFWQALFMIATIWIVAIGVKK 170

Query: 183 GIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSV 242
           GIER  K++MPLL V  + L IY   LG           +G  F++SP+W+ LK+    V
Sbjct: 171 GIERSNKILMPLLGVLLIALAIYSLTLG--------GAKEGLAFLFSPDWSALKDP--GV 220

Query: 243 MLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAV 302
            LAA  Q FFTLSLGMG +  Y SY+     +  + ++   L+    ++ G         
Sbjct: 221 YLAAISQAFFTLSLGMGALITYGSYVSKDSRLPGAAVSVAGLDTAFAIIAG--------- 271

Query: 303 AYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWF 362
                ++ P V A G       +S + G G  +  LP+IF  +   G   G  +F+LL  
Sbjct: 272 ----IMIFPAVFALG-------LSPSGGPGLVFVVLPDIFDSI-RLGPIVGIAFFILLGA 319

Query: 363 AGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQV 415
           A  +SA+++     A        SRK     + +I  LLGIP     G L +V
Sbjct: 320 AALSSAVSLLEVPVAYFMRKFDWSRKQAAITLGVIITLLGIPSSLSFGVLGEV 372


>pir||G82096 sodium-dependent transporter VC2283 [imported] - Vibrio cholerae
           (group O1 strain N16961) >gi|9656846|gb|AAF95427.1|
           (AE004299) sodium-dependent transporter [Vibrio
           cholerae]
           Length = 451
           
 Score =  166 bits (415), Expect = 8e-40
 Identities = 130/489 (26%), Positives = 230/489 (46%), Gaps = 57/489 (11%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           Q   R+ +++++G ILA AG A+GLGN   FPTQ A NGGGAF++ Y + +F++  P++ 
Sbjct: 3   QSNSRETFSSRLGFILAAAGAAVGLGNIWGFPTQAASNGGGAFLLVYLILIFVVAFPMLV 62

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
           VE   GRY      G   P   + +  S +P +  + G +G  +  +  + + ++Y  + 
Sbjct: 63  VEMAIGRY------GQANPVDSMRSLTS-QPAAKKVGGFVGW-VGLSVPSAVLAFYSIVG 114

Query: 127 GWSAAYSWFSISGAYFNVESTAKFFESYLSNHGL--VFLFWGITVVLLAIAVGQGVSKGI 184
           GW   +   +++   F   + + + + +     L    +F+ +T+++    V  GV +GI
Sbjct: 115 GWIICFLLGAMTD-LFGFTAASAWLKGFSVERNLFGTLIFYVLTILI----VQGGVKQGI 169

Query: 185 ERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVML 244
           ERW   +MP L+V   +L IY+          +   I  FE +W             ++L
Sbjct: 170 ERWSTRLMPALFVLFAVLFIYIMTQQGAWEGLKHYLIPDFEKVWDR----------KLIL 219

Query: 245 AASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAY 304
           AA GQ FF+L++G   +  Y SYL  K+++    + +V+L + A   + G + +P     
Sbjct: 220 AAMGQGFFSLTIGGCSMLIYGSYLSKKENLPKMAM-SVTLVDTAVAFIAGLVVLP----- 273

Query: 305 APKIVPPEVLAKGSNAALQWISENFGLGFS----YTSLPNIFVQMGTAGRFFGALWFLLL 360
                    +    N  +Q  +++  L  S    +T LP +F  +G  G+ F  ++FLLL
Sbjct: 274 --------AMFVAMNKGVQIYAQDGSLLSSDTLVFTVLPLMFDSLGLLGQIFAMVFFLLL 325

Query: 361 WFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWIS 420
             A  TS+I+M     AL+ E     R   +W++  +  L  + +VY  G L  + A ++
Sbjct: 326 TIAALTSSISMLECPVALVGERFNTRRTPTSWVLGGLIALFSVVIVYNFGALFGLVATLA 385

Query: 421 FQL--ALLALFDIIVGVWLFKPDNFWKELHEGALINVPE--------FYKWITVIIAPIF 470
            Q      AL   + G W+++ D   KEL  G     PE         + W    + P+ 
Sbjct: 386 TQYLQPTAALMFCLFGGWVWQRDAKMKELQAG----FPELQQSLFGKIWPWYVKFVCPVL 441

Query: 471 IALPLFGTF 479
           +A  ++ +F
Sbjct: 442 VATVIWASF 450


>pir||B82171 probable sodium-dependent transporter VC1669 [imported] - Vibrio
           cholerae (group O1 strain N16961)
           >gi|9656184|gb|AAF94819.1| (AE004245) sodium-dependent
           transporter, putative [Vibrio cholerae]
           Length = 448
           
 Score =  161 bits (404), Expect = 2e-38
 Identities = 125/475 (26%), Positives = 224/475 (46%), Gaps = 46/475 (9%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R ++ ++ G I+A AG+A+GLGN   FPTQ A NGG  F++ Y   +FLL  P++  E  
Sbjct: 10  RGQFTSRFGFIMAAAGSAVGLGNVWGFPTQAASNGGAVFLLVYLCMVFLLAYPMLVAELT 69

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPR---SALIFGLIGGALAFATTTLLNSYYLHLIG 127
            GRY         G +  + A  S+ P+    A++ G+IG        +L+ S+Y  + G
Sbjct: 70  IGRY---------GQSNPIRAFRSVWPQGKWGAILLGVIG----MVVVSLILSFYAIVAG 116

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
           W    S F         +S +++  S+ +   L+ +     +VL    V  GV+ GIE+W
Sbjct: 117 WLVG-SLFGSGLTLIGADSASQWLTSFSTERNLILMV--SFMVLTMFVVRNGVANGIEKW 173

Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
              +MPLL+V   +L +Y+F         Q   + G +    P+ ++       V+++A 
Sbjct: 174 STRLMPLLFVLFGLLTVYIFT--------QEGALDGLKMYLVPDLSHFTP---DVVVSAM 222

Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
           GQ FF+LSLG+ ++  Y SYL  + ++  +  A V+L +     + G + +P    +  K
Sbjct: 223 GQAFFSLSLGVCVMTTYGSYLNKEANLPKTA-AQVALIDTGVAFIAGLMVLP--AMFVAK 279

Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
               E+ +       + ++ +      +T LP +F  MG  G   G ++FLL+  A  TS
Sbjct: 280 HNGVEIFSSSG----ELLNSD---TLVFTVLPAMFDTMGAVGAVIGIIFFLLMIIAALTS 332

Query: 368 AIAMYNYLTALLEEDLGISRKTGT-WIVFIIYFLLGIPVVYINGYLDQVDAWIS-FQLAL 425
           +I+M     A   E+L   R +   WI  ++  + G+ V+  +     V  + + +   +
Sbjct: 333 SISMLEVPVACAVEELQQKRSSAVLWIGGLVTIISGVIVLNFSSLFGLVINFTTVYSQPI 392

Query: 426 LALFDIIVGVWLFKPDNFWKELHEGAL-INVPEFYK---WITVIIAPIFIALPLF 476
           +AL   ++  W++  +    EL +G   I    F+K   W   ++ P+ + +  F
Sbjct: 393 IALLITLIAGWIWNRNQILSELKQGCPDIENSLFWKIWPWYVRLVCPVLMLMVFF 447


>pir||E81964 probable sodium-dependent inner membrane transport protein NMA0470
           [imported] - Neisseria meningitidis (group A strain
           Z2491) >gi|7379216|emb|CAB83765.1| (AL162753) putative
           sodium-dependent inner membrane transport protein
           [Neisseria meningitidis Z2491]
           Length = 511
           
 Score =  156 bits (390), Expect = 7e-37
 Identities = 137/508 (26%), Positives = 237/508 (45%), Gaps = 76/508 (14%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           ++R  + T+   ++A  G+A+GLGN  RFP     NGGGAF++PY +AL   GIP++ ++
Sbjct: 7   KERATFGTRRAFMIAAIGSAVGLGNIWRFPYIAFENGGGAFILPYLVALLTAGIPLLLLD 66

Query: 69  WVQG-RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           +  G RY G        P  +       +P          G     T  ++  YY  +IG
Sbjct: 67  YAIGHRYRGS------APLAFRRLGRWFEP---------VGWWNVMTNIVICIYYAVIIG 111

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFL--------------FWGITVVLLA 173
           W+A+Y+++S++ A+   +    FF+ +L   G   L               W  T  ++A
Sbjct: 112 WAASYTYYSVNAAW-GADPQGFFFKDFLQMAGPEALGLDFVGKVAGPLAGVWVFTAAIMA 170

Query: 174 IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWT 233
           +    GV KG+ R     MPLL      LV+++  +G  L  P     KG + +++P+W+
Sbjct: 171 L----GVQKGVARASSFFMPLL------LVMFLIMVGISLTLP--GAAKGLDALFTPDWS 218

Query: 234 YLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLG 293
            L +    V +AA GQIFF+LS+  GI+  Y+SYL  K D+  +GL     N   E++ G
Sbjct: 219 KLADS--KVWVAAYGQIFFSLSICFGIMVTYSSYLKKKTDLGGTGLVVGFANSSFELLAG 276

Query: 294 GSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFG 353
             I V  A+ +         +A+    A+  ++   G+G ++ + P I +     G   G
Sbjct: 277 --IGVFAALGF---------MAQAGGKAVNEVASG-GIGLAFIAFPTI-INQAPMGWLIG 323

Query: 354 ALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLL---------GIP 404
            L+F  L FAG TS I++   + A +++ L I R   T +V I   ++         G+P
Sbjct: 324 ILFFGSLVFAGVTSMISILEVIVAAIQDKLNIGRVNATLLVCIPMGIVSTLLFGTATGLP 383

Query: 405 VVYINGYLDQVDAWISFQLALLALFDIIVGVWLF-KPDNFWKELHEGALINVPEFYKWIT 463
           V      LD +D +++    + A F  +  + +  +     K L+  + I +   +  + 
Sbjct: 384 V------LDVMDKFVNTYGIVAAGFVYVAAIIISGRLPELRKHLNALSSIRIGGLWT-VC 436

Query: 464 VIIAPIFIALPLFGTFTDLVSKTL-GWP 490
           V++  + +   LF   + L+ K   G+P
Sbjct: 437 VVVTVVMLGYMLFKDTSGLMEKNYEGYP 464


>pir||H81019 sodium- and chloride-dependent transporter NMB1975 [imported] -
           Neisseria meningitidis (group B strain MD58)
           >gi|7227236|gb|AAF42303.1| (AE002546) sodium- and
           chloride-dependent transporter [Neisseria meningitidis
           MC58]
           Length = 511
           
 Score =  156 bits (390), Expect = 7e-37
 Identities = 137/508 (26%), Positives = 237/508 (45%), Gaps = 76/508 (14%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           ++R  + T+   ++A  G+A+GLGN  RFP     NGGGAF++PY +AL   GIP++ ++
Sbjct: 7   KERATFGTRRAFMIAAIGSAVGLGNIWRFPYIAFENGGGAFILPYLVALLTAGIPLLLLD 66

Query: 69  WVQG-RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           +  G RY G        P  +       +P          G     T  ++  YY  +IG
Sbjct: 67  YAIGHRYRGS------APLAFRRLGRWFEP---------VGWWNVMTNIVICIYYAVIIG 111

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFL--------------FWGITVVLLA 173
           W+A+Y+++S++ A+   +    FF+ +L   G   L               W  T  ++A
Sbjct: 112 WAASYTYYSVNAAW-GADPQGFFFKDFLQMAGPEALGLDFVGKVAGPLAGVWVFTAAIMA 170

Query: 174 IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWT 233
           +    GV KG+ R     MPLL      LV+++  +G  L  P     KG + +++P+W+
Sbjct: 171 L----GVQKGVARASSFFMPLL------LVMFLIMVGISLTLP--GAAKGLDALFTPDWS 218

Query: 234 YLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLG 293
            L +    V +AA GQIFF+LS+  GI+  Y+SYL  K D+  +GL     N   E++ G
Sbjct: 219 KLADS--KVWVAAYGQIFFSLSICFGIMVTYSSYLKKKTDLGGTGLVVGFANSSFELLAG 276

Query: 294 GSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFG 353
             I V  A+ +         +A+    A+  ++   G+G ++ + P I +     G   G
Sbjct: 277 --IGVFAALGF---------MAQAGGKAVNEVASG-GIGLAFIAFPTI-INQAPMGWLIG 323

Query: 354 ALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLL---------GIP 404
            L+F  L FAG TS I++   + A +++ L I R   T +V I   ++         G+P
Sbjct: 324 ILFFGSLVFAGVTSMISILEVIVAAIQDKLNIGRVNATLLVCIPMGIVSTLLFGTATGLP 383

Query: 405 VVYINGYLDQVDAWISFQLALLALFDIIVGVWLF-KPDNFWKELHEGALINVPEFYKWIT 463
           V      LD +D +++    + A F  +  + +  +     K L+  + I +   +  + 
Sbjct: 384 V------LDVMDKFVNTYGIVAAGFVYVAAIIISGRLPELRKHLNALSSIRIGGLWT-VC 436

Query: 464 VIIAPIFIALPLFGTFTDLVSKTL-GWP 490
           V++  + +   LF   + L+ K   G+P
Sbjct: 437 VVVTVVMLGYMLFKDTSGLMEKNYEGYP 464


>pir||F81050 sodium- and chloride-dependent transporter NMB1707 [imported] -
           Neisseria meningitidis (group B strain MD58)
           >gi|7226963|gb|AAF42055.1| (AE002521) sodium- and
           chloride-dependent transporter [Neisseria meningitidis
           MC58]
           Length = 445
           
 Score =  155 bits (387), Expect = 1e-36
 Identities = 127/486 (26%), Positives = 204/486 (41%), Gaps = 70/486 (14%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           M     W++KIG +LA AG+AIGLG   +FP     NGG  F + + +   L+ +PV   
Sbjct: 1   MSNHTSWSSKIGFVLAAAGSAIGLGAIWKFPYTAGTNGGAVFFLLFLIFTILVALPVQLA 60

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           E+  GR GGK    +            L+P +  ++    G +  A   +L S+Y  + G
Sbjct: 61  EFYIGRTGGKNAVDSF---------RVLRPGTQWLW---VGRMGVAACFILLSFYSVVGG 108

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
           W   Y   S +GA          F + +SN      +  + +++    V  G+S GIE+ 
Sbjct: 109 WVLNYVVHSFTGAVHTGADFEALFGATISNPAGSLSYQALFMLITVWVVKGGISDGIEKA 168

Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
            + +MP L++  + L I    L           ++G  F+  PNW+Y K      M+ A 
Sbjct: 169 NRYLMPGLFILFIALAIRSLTLP--------GAMEGVSFLLKPNWSYFKA---DTMITAL 217

Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
           GQ FF LS+G+  +  YASYLG   D+  SG   + +N    ++ G              
Sbjct: 218 GQAFFALSIGVSAMITYASYLGKDQDMFRSGHTIMWMNLLVSLLAG-------------L 264

Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
           ++ P V A G          + G G  +  LP +F++M   G    A++ LL+ FA  TS
Sbjct: 265 VIFPAVFAFG-------FEPSQGPGLIFIVLPAVFMKM-PFGTVLFAVFMLLVVFATLTS 316

Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
           A +M   + A         RK  TW++    F++GIP     G       W  F++    
Sbjct: 317 AFSMLETVIASTIRQDERKRKKHTWLIGTAIFIIGIPSALSFG------VWGEFKVFGKT 370

Query: 428 LFDI------------------IVGVWLFKPDNFWKELHEGALINVPEFYKWITVI--IA 467
           +FD+                  I   W+    +  K+   G+ +       W+  +  +A
Sbjct: 371 IFDLWDYVISAVIMPIGALSVSIFTAWIQDKQSVLKDAGAGSTVPRAVLLLWLNTLRYLA 430

Query: 468 PIFIAL 473
           PI I +
Sbjct: 431 PIAIII 436


>pir||G81824 probable integral membrane ion transporter NMA1961 [imported] -
           Neisseria meningitidis (group A strain Z2491)
           >gi|7380593|emb|CAB85181.1| (AL162757) putative integral
           membrane ion transporter [Neisseria meningitidis Z2491]
           Length = 445
           
 Score =  154 bits (386), Expect = 2e-36
 Identities = 118/424 (27%), Positives = 186/424 (43%), Gaps = 50/424 (11%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           M     W++KIG +LA AG+AIGLG   +FP     NGG  F + + +   L+ +PV   
Sbjct: 1   MSNHTSWSSKIGFVLAAAGSAIGLGAIWKFPYTAGTNGGAVFFLLFLIFTILVALPVQLA 60

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           E+  GR GGK    +            L+P +  ++    G +  A   +L S+Y  + G
Sbjct: 61  EFYIGRTGGKNAVDSF---------RVLRPGTQWLW---VGRMGVAACFILLSFYSVVGG 108

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
           W   Y   S +GA          F + +SN      +  + +++    V  G+S GIE+ 
Sbjct: 109 WVLNYVVHSFTGAVHTGADFEALFGATISNPAGSLSYQALFMLITVWVVKGGISDGIEKA 168

Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
            + +MP L++  + L I    L           ++G  F+  PNW+Y K      M+ A 
Sbjct: 169 NRYLMPGLFILFIALAIRSLTLP--------GAMEGVSFLLKPNWSYFKA---DTMITAL 217

Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
           GQ FF LS+G+  +  YASYLG   D+  SG   + +N    ++ G              
Sbjct: 218 GQAFFALSIGVSAMITYASYLGKDQDMFRSGHTIMWMNLLVSLLAG-------------L 264

Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
           ++ P V A G          + G G  +  LP +F++M   G    A++ LL+ FA  TS
Sbjct: 265 VIFPAVFAFG-------FEPSQGPGLIFIVLPAVFMKM-PFGTVLFAVFMLLVVFATLTS 316

Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
           A +M   + A         RK  TW++    F++GIP     G       W  F++    
Sbjct: 317 AFSMLETVIAATIRQDERKRKKHTWLIGTAIFIVGIPSALSFG------VWGEFKVFGKT 370

Query: 428 LFDI 431
           +FD+
Sbjct: 371 IFDL 374


>gb|AAG19816.1| (AE005066) sodium- and chloride-dependent transporter; Nac
           [Halobacterium sp. NRC-1]
           Length = 477
           
 Score =  152 bits (381), Expect = 8e-36
 Identities = 139/516 (26%), Positives = 221/516 (41%), Gaps = 60/516 (11%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           RD W +++G I+A  G+A+GLGN  RFP   + NGG AF++ Y   +  +G+P +  E+V
Sbjct: 3   RDVWHSRLGFIMAAVGSAVGLGNLWRFPWMTSENGGAAFLLVYLGVVLCVGVPGLLAEFV 62

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            GR   +   G            +    S      + G L+     +L S+Y  + GW  
Sbjct: 63  IGRRSRRSPVG------------AFSSLSDSTLWRVFGHLSVVIAVVLLSFYSVVGGWIL 110

Query: 131 AYSWFSISGAYFNVESTAKFFESY-LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVK 189
            Y   S++GAYF+         SY L   G   LF  IT     + V +G+ +GIE   K
Sbjct: 111 RYFGASLTGAYFSNPGQYFATVSYGLDAVGFHLLFLAIT----GLIVVRGIKRGIENATK 166

Query: 190 VMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQ 249
           +MMP + V  ++L  +   L             G  F  SP+   L+  L  ++ AA+GQ
Sbjct: 167 LMMPAVVVLLIVLAAWASTLD--------GAGAGLAFYLSPDVELLEADLLGILPAAAGQ 218

Query: 250 IFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIV 309
             FTLSLG G +  YASYL  +  +A  G A   LN     VL G +  PL         
Sbjct: 219 ALFTLSLGSGTMITYASYLDEERSLAADGAAIAVLNTCIG-VLAGLVVFPLLF------- 270

Query: 310 PPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI 369
                      AL   +   G G  +  L N FV +   GR  GA++F ++  A  +S+I
Sbjct: 271 -----------ALVGDAGTGGPGALFVGLANAFVAV-PYGRAVGAVFFAVVSLAAISSSI 318

Query: 370 AMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALF 429
           +M     + L ++ G+SR+  T +   ++ + G       G  D V   +   L    L 
Sbjct: 319 SMLELPVSFLVDEYGVSRRRATALFVGVFTVTGSATALSPGLFDFVAGTLVDLLMTAGLI 378

Query: 430 DIIVGVWLFKPDNFWKELHEGA-----LINVPEFYK--------WITVIIAPIFIALPLF 476
             ++        N   E   GA      ++ P  Y          I  +++ I  AL + 
Sbjct: 379 GFLLFTGWVVGQNAVTEYELGAGAVASALSTPWLYAVGVVIPVFLIFTLVSGIAAALGVS 438

Query: 477 GTFTDLVSKTLGWPAKIAIIAMLIIGAIEAYYAIKK 512
            T  +L   T+  P   A ++++I  A+ ++  +++
Sbjct: 439 ITAVELWGVTISQPRLFAGLSVVI--AVVSFLGLRR 472


>pir||T46663 probable sodium/chloride ion channel [imported] - Neisseria
           meningitidis >gi|4433817|gb|AAD20893.1| (U58765)
           putative sodium/chloride ion channel [Neisseria
           meningitidis]
           Length = 445
           
 Score =  152 bits (380), Expect = 1e-35
 Identities = 116/424 (27%), Positives = 187/424 (43%), Gaps = 50/424 (11%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           M     W++KIG +LA AG+AIGLG   +FP     NGG  F + + +   L+ +PV   
Sbjct: 1   MSNHTSWSSKIGFVLAAAGSAIGLGAIWKFPYTAGTNGGAVFFLLFLIFTVLVALPVQLA 60

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           E+  GR GG+    +           +L+P +  ++    G +  +   +L S+Y  + G
Sbjct: 61  EFYIGRTGGQNAVDSF---------RALRPSTQWLW---VGRMGVSACFILLSFYSVVGG 108

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
           W   Y   S +GA          F + +SN      +  + +++    V  G+S GIE+ 
Sbjct: 109 WVLNYVVHSFTGAVHTGADFEALFGATISNPAGSLSYQALFMLITVWVVKGGISDGIEKA 168

Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
            + +MP L++  + L I    L           ++G  F+  PNW+Y K      M+ A 
Sbjct: 169 NRYLMPGLFILFIALAIRSLTLP--------GAMEGVSFLLKPNWSYFKA---DTMITAL 217

Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
           GQ FF LS+G+  +  YASYLG   D+  SG   + +N    ++ G              
Sbjct: 218 GQAFFALSIGVSAMITYASYLGKDQDMFRSGHTIMWMNLLVSLLAG-------------L 264

Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
           ++ P V A G          + G G  +  LP +F++M   G    A++ LL+ FA  TS
Sbjct: 265 VIFPAVFAFG-------FEPSQGPGLIFIVLPAVFMKM-PFGTVLFAVFMLLVVFATLTS 316

Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
           A +M   + A         RK  TW++    F++GIP     G       W  F++    
Sbjct: 317 AFSMLETVIASTIRQDERKRKKHTWLIGTAIFIVGIPSALSFG------IWGEFKVFGKT 370

Query: 428 LFDI 431
           +FD+
Sbjct: 371 IFDL 374


>pir||D69902 sodium-dependent transporter homolog yocR - Bacillus subtilis
           >gi|2619056|gb|AAB84480.1| (AF027868) putative
           transporter [Bacillus subtilis]
           >gi|2634327|emb|CAB13826.1| (Z99114) similar to
           sodium-dependent transporter [Bacillus subtilis]
           Length = 445
           
 Score =  150 bits (376), Expect = 3e-35
 Identities = 131/492 (26%), Positives = 223/492 (44%), Gaps = 67/492 (13%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           M++ ++W++K+G ILA AG+AIGLG   +FP     +GGGAF++ + L   L+G+P++  
Sbjct: 1   MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLLIFILFTVLIGLPLLLG 60

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           E++ GR   K           + + ++L P +   +    G L   T  +L S+Y  + G
Sbjct: 61  EFIIGRRTQKDA---------VQSYKTLAPGTKWHW---IGYLGMVTCFILLSFYSVVGG 108

Query: 128 WSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERW 187
           W   Y     +G           F S +SN  L      + +V+  + V +GVS GIE+ 
Sbjct: 109 WILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKGVSSGIEKA 168

Query: 188 VKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAAS 247
            +V+MP L++  +IL++    L           ++G +F   P+ T +     + +L A 
Sbjct: 169 SQVLMPALFLLFIILMVRSVTLD--------GAMEGIKFFLMPDLTAIDA---NTILYAM 217

Query: 248 GQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPK 307
           GQ FF LS+G+ ++  Y++YL  ++++  S ++   +N    V+ G +I           
Sbjct: 218 GQSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIF---------- 267

Query: 308 IVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTS 367
              P V + G       +  + G    +  LP +F QM   G  F   + LL  FA  TS
Sbjct: 268 ---PAVFSFG-------LKPDQGPVLLFNVLPTVFNQM-PFGIIFLLAFLLLFLFAALTS 316

Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
           A +M   L A+L +     RK   W+  I  F++G+P     G L  V     F L++  
Sbjct: 317 AFSMLEILVAVLSKGDINKRKRFAWLGGIAIFIVGVPSALSYGVLSDVTI---FHLSIFD 373

Query: 428 LFDIIVG----------VWLFKP-----DNFWKELHEGALINVPEFYKWITVI-----IA 467
             D +V           + +F P      + + EL  G+ +    F  W+ +I     +A
Sbjct: 374 AADYLVSNILMPLGALLISIFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVA 433

Query: 468 PIFIALPLFGTF 479
            I + L + G F
Sbjct: 434 IIIVFLHVIGIF 445


>pir||F69825 sodium-dependent transporter homolog yhdH - Bacillus subtilis
           >gi|2226203|emb|CAA74492.1| (Y14082) hypothetical
           protein [Bacillus subtilis] >gi|2633282|emb|CAB12786.1|
           (Z99109) similar to sodium-dependent transporter
           [Bacillus subtilis]
           Length = 451
           
 Score =  150 bits (375), Expect = 4e-35
 Identities = 139/486 (28%), Positives = 219/486 (44%), Gaps = 67/486 (13%)

Query: 13  KWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQG 72
           +WA+KIG ++A AG+AIGLG   +FP     NGGGAF + + L   LLG P++  E++ G
Sbjct: 8   QWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAFFLIFVLFTILLGYPLLVGEFIFG 67

Query: 73  RYGGKYGHGTLGPTFYLMARESLKPRSA-LIFGLIGGALAFATTTLLNSYYLHLIGWSAA 131
           R            T  + A +   PRSA  + G IG A  F    L+ S+Y  + GW   
Sbjct: 68  R---------RNQTNAIDAYKKEAPRSAWFLTGWIGVAACF----LVLSFYSVIGGWILL 114

Query: 132 YSWFSISGAYFNVEST--AKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVK 189
           Y   + SG+   +        F S + N         + + L  + V +GV KGIER   
Sbjct: 115 YIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLVVARGVQKGIERVSA 174

Query: 190 VMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQ 249
           VMMP+L++  ++LV+    L           ++G +F+  P++  L       +L A GQ
Sbjct: 175 VMMPILFLLFILLVLRSLTLN--------GAMEGVKFLLVPHFGDLTP---ESILFALGQ 223

Query: 250 IFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIV 309
            FFTL+LG+ ++  Y+SYL    ++  S  + V +N    ++ G +I             
Sbjct: 224 AFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIF------------ 271

Query: 310 PPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLW-FAGFTSA 368
            P V + G          N G    +T LP +F Q+     FF  + FL+ + FA  TSA
Sbjct: 272 -PAVFSFG-------FQPNEGPTLLFTVLPAVFEQLPFGTLFF--IGFLVAFLFAALTSA 321

Query: 369 IAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAW--ISFQLALL 426
            +M   + A + +     RK  +W   ++ FL+GIP     G L  V  +    F +A  
Sbjct: 322 FSMVEIIVATIGKGDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADF 381

Query: 427 ALFDIIVG-----VWLFKPDNFWK-----ELHEGALINVPEFYKWITVI-----IAPIFI 471
            + ++++      + LF P    K     E+  G+      FY W  ++     +A I +
Sbjct: 382 TVSNVLMPSGALLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIV 441

Query: 472 ALPLFG 477
            L L G
Sbjct: 442 FLNLIG 447


>dbj|BAB03936.1| (AP001507) sodium-dependent transporter [Bacillus halodurans]
           Length = 457
           
 Score =  148 bits (370), Expect = 1e-34
 Identities = 131/479 (27%), Positives = 213/479 (44%), Gaps = 60/479 (12%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           + +W++K+  ILA AG+A+GLG   +FP     +GGGAF + + L   L+G+P++  E+V
Sbjct: 2   KQQWSSKLAFILAAAGSAVGLGAIWKFPYVTGTSGGGAFFLIFILFTLLIGLPLLIGEFV 61

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            GR   K           + +  ++ P S+  +G + G L   T  LL S+Y  + GW  
Sbjct: 62  IGRSTQKNA---------IESYRAIAPNSS--WGGV-GKLGIFTCFLLLSFYSVIGGWII 109

Query: 131 AYSWFSISGAYFNVES--TAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWV 188
            Y   +I+G    ++     + F   +SN  L        + ++   V +GV KGIER  
Sbjct: 110 IYFLKAITGQLSGLDEGRYGEIFAETISNPILAISSQFAFLAIVMYVVSRGVKKGIERAS 169

Query: 189 KVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASG 248
            +MMP L+V  + +VI    L            +G  F   P+++ +       +L A G
Sbjct: 170 VIMMPALFVLFLAIVIRGLTLD--------GATEGLAFFLVPDFSTITS---ETLLYAMG 218

Query: 249 QIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKI 308
           Q FF LS+G+ ++  Y+SYL   + +  S L+ V L  F    L G    P   ++    
Sbjct: 219 QSFFALSVGVSVMVTYSSYLSRDESIVQSALSIVMLT-FVVAFLAGVAIFPAVFSFG--- 274

Query: 309 VPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA 368
                           +S + G    +  LP++F QM   G FF   + LL  FA  TSA
Sbjct: 275 ----------------MSPDEGPVLLFNVLPSVFDQM-PYGAFFLVTFLLLFLFATLTSA 317

Query: 369 IAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP-----------VVYINGYLDQVDA 417
            +M   + A + +     R   TW++ +  F +GIP           +++     D  D 
Sbjct: 318 FSMLEVVVAAITKGDVSQRPKVTWLIGLAIFAVGIPSALSYGVWSDVLLFGRTVFDTADF 377

Query: 418 WISFQLALLALFDIIVGVWL-FKPDNFWKELHEGALINVPEFYKWITVI--IAPIFIAL 473
            +S  L  +    I + V L    +  ++E+  GA I    F  W  +I  +API IA+
Sbjct: 378 LVSNILMPIGALLIAIFVPLKISKERLYEEIKAGASIGKRLFAIWFILIRYVAPIVIAI 436


>dbj|BAB07158.1| (AP001518) sodium-dependent transporter [Bacillus halodurans]
           Length = 505
           
 Score =  148 bits (370), Expect = 1e-34
 Identities = 149/515 (28%), Positives = 232/515 (44%), Gaps = 62/515 (12%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R++W T+ G ILA  G+A+GLGN  RFP     NGGGAF +PY  AL   GIP++ +E+ 
Sbjct: 2   REQWGTRAGFILAAVGSAVGLGNIWRFPYVAYENGGGAFFIPYLFALLTAGIPLLIMEFT 61

Query: 71  QG-RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
            G +Y G        P  Y         + A   G    A++F   T    YY  +I W+
Sbjct: 62  IGQKYRGS------APLSYARLN-----KKAEWIGWWQVAISFVIAT----YYAVIIAWA 106

Query: 130 AAYSWFSISGAYFNVESTAKF-FESYLS---NHGLV-FLFWGITVVLL---AIAVG---Q 178
            +YS F+I+ ++   E T  F F  YL    + G +  L  G+ + L+    +A+G    
Sbjct: 107 MSYSVFAINLSW--GEDTGGFLFGEYLKLDVDPGQIGSLVPGVFIPLVLVWIVALGVLFA 164

Query: 179 GVSKGIERWVKVMMPLLYVFAVILVIYVFAL-GSPLGQPQWSTIKGFEFIWSPNWTYLKE 237
           GV KGIE   ++ +P L +  +I+VI    L G+ +         G +  + P+W+ +  
Sbjct: 165 GVKKGIELANRIFIPTLVIMFLIIVIRAVTLEGAAI---------GLDAFFKPDWSEILS 215

Query: 238 HLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLG-GSI 296
               V +AA GQIFF+LS+   I+  Y+SYL  K DV  +       N   E++ G G  
Sbjct: 216 P--GVWVAAYGQIFFSLSIAFAIMITYSSYLPRKADVNNNAFIAGFSNSGFELLAGIGVF 273

Query: 297 AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALW 356
           AV   +A        EV A              G+G ++   P I   +      FG L+
Sbjct: 274 AVLGFMATQAGTTVGEVAAG-------------GIGLAFVVFPQIINSLPGLNGLFGFLF 320

Query: 357 FLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING--YLDQ 414
           F  L FAG +S I++     + L++   ISR         +  L+ +      G   LD 
Sbjct: 321 FASLVFAGLSSLISIVETFVSALQDKFKISRTKAVLFGGGLSALISLLFATQGGLFLLDA 380

Query: 415 VDAWI-SFQLALLALFDIIVGVWLFKPDN-FWKELHEGALINVPEFYKWITVIIAPIFIA 472
            D +I SF +AL  L  ++   W FK  N   K  +E + +    ++K    +I PI + 
Sbjct: 381 ADHFINSFGVALAGLVSVVAVSWFFKQLNPLQKHGNEVSDLRTGTWWKVCLGVITPIVLG 440

Query: 473 LPLFGTFTDLVSKTL-GWPAKIAIIA--MLIIGAI 504
                   + +S+   G+P    + +   + +GAI
Sbjct: 441 YMAVQNIINSISENYEGYPTSFLLYSGWGVAVGAI 475


>pir||F81367 probable transmembrane transport protein Cj0935c [imported] -
           Campylobacter jejuni (strain NCTC 11168)
           >gi|6968372|emb|CAB73192.1| (AL139076) putative
           transmembrane transport protein [Campylobacter jejuni]
           Length = 444
           
 Score =  145 bits (361), Expect = 2e-33
 Identities = 112/390 (28%), Positives = 189/390 (47%), Gaps = 43/390 (11%)

Query: 16  TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
           +KIG ILA+AG+A+GLGN  +FPT V  +GG AF++ Y +    +G  +   E   G+  
Sbjct: 6   SKIGFILAVAGSAVGLGNAWKFPTLVGQSGGSAFILLYIILTLGVGFVIFLAELSIGKIS 65

Query: 76  GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
            K           + A E L P +   +  +G  +  A   L+ S+Y  +IGW   Y + 
Sbjct: 66  EKDP---------VNAYEKLAPSNKKAWSYVGFTMVGAI--LIVSFYTLVIGWIVKYVFL 114

Query: 136 SISGAY-FNVESTAKFFESYLSNHGLV-FLFWGITVVLLAIAVGQGVSKGIERWVKVMMP 193
           SI+G    ++E +   F  ++S   L  F+ + +  + +   V +GV  GIE+    MMP
Sbjct: 115 SITGNLPMDLEVSKAQFGFFISEDFLSQFICFTLVFLCVFYIVSKGVKNGIEKLNVWMMP 174

Query: 194 LLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFT 253
            L++  +++++Y  +            I   +F++ P+++ +     S +L A G  FF+
Sbjct: 175 SLFILLILMLVYAISKDG--------FIMAVKFLFVPDFSKINT---SNVLEALGLAFFS 223

Query: 254 LSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEV 313
           LSLG+G I  Y++ L  K +   S L  + +N    +++G              +V   +
Sbjct: 224 LSLGVGTIITYSASLPDKTNFITSTLNIIFINLLVGLLMG-------------LVVFTFI 270

Query: 314 LAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYN 373
              G N   Q      G G  + SL  +F ++G  G  FGA +F+ L FAG TSA++M  
Sbjct: 271 FEFGYNPNQQ------GPGLVFISLATLFEKIGVIGCIFGAAFFISLIFAGITSAVSMIE 324

Query: 374 YLTALLEEDLGISRKTGTWIVFIIYFLLGI 403
             T  L    G+SRK    ++ I+ ++LG+
Sbjct: 325 PFTFYLINTFGMSRKKALILIGIVVYILGM 354


>pir||G71930 probable transporter - Helicobacter pylori (strain J99)
           >gi|4154986|gb|AAD06028.1| (AE001479) putative
           transporter [Helicobacter pylori J99]
           Length = 442
           
 Score =  140 bits (349), Expect = 4e-32
 Identities = 128/474 (27%), Positives = 213/474 (44%), Gaps = 63/474 (13%)

Query: 16  TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
           +K+G ILA  G++IGLG+  RFP  V  NGG AF++ Y      LGI ++ VE + G  G
Sbjct: 5   SKLGFILATLGSSIGLGHIWRFPYMVGHNGGSAFVLLYLALTLSLGIAMLLVEMLIGNLG 64

Query: 76  GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
            K     +   + ++  +  K      F ++GG        L+ S+Y  ++GW   Y + 
Sbjct: 65  KK----DVVSNYQILDPKRKKYYPFTSFFILGG-------PLILSFYAVVLGWVLYYLFV 113

Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIA--VGQGVSKGIERWVKVMMP 193
                  ++E  AK   S L N  L++   G +  LL     V +G+ KGIE+   V+MP
Sbjct: 114 VTFDLPKDLEQ-AKMQFSMLQNGSLIWPVIGFSACLLPTIWFVSRGIEKGIEKLNVVLMP 172

Query: 194 LLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFT 253
           LL+V  + L+IY   L         S  K   F+++     +++  + V++ A GQ+FF+
Sbjct: 173 LLFVIFIGLLIYAMTLE--------SMPKALRFLFN---FEIQKIDFKVVMDALGQMFFS 221

Query: 254 LSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEV 313
           LSLG+G I  Y+++   K+++  S L  V       ++ G  I   +   +A        
Sbjct: 222 LSLGVGTIITYSAFTPKKENLLKSSLFIVLPGILISLIAGVMIFTFVFEYHAD------- 274

Query: 314 LAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYN 373
                      +S+  G G  + SLP  F +MG +G+     +F+ L FAG TS +++  
Sbjct: 275 -----------VSQ--GPGLVFISLPLTFAKMGISGQIVSLFFFMALVFAGITSTVSLIE 321

Query: 374 YLTALLEEDLGISR-KTGTWIVFIIYFLLGIPVVYIN---------------GYLDQVDA 417
            L   L      SR K   WI  ++Y L  + ++ +N               G+LD + +
Sbjct: 322 PLALYLINRFNFSRLKASLWIGVVVYVLGVLVILSMNERYAKFLSFAHKSVFGWLDFITS 381

Query: 418 WISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
             SF + L  LF ++   W+      +         N  + + +    IAP+ I
Sbjct: 382 --SFLMPLGGLFSVLFIGWILNKKRSFLATKHFFSANAFKAWHFSVRFIAPVVI 433


>sp|P45320|YG90_HAEIN HYPOTHETICAL SODIUM-DEPENDENT TRANSPORTER HI1690
           >gi|1075054|pir||H64136 neurotransmitter transport
           protein homolog - Haemophilus influenzae (strain Rd
           KW20) >gi|1574543|gb|AAC23336.1| (U32842)
           sodium-dependent transporter, putative [Haemophilus
           influenzae Rd]
           Length = 457
           
 Score =  140 bits (349), Expect = 4e-32
 Identities = 112/405 (27%), Positives = 192/405 (46%), Gaps = 45/405 (11%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           +QR  W++++  ++ +AG  +G G   RFP  V  NGGGA+++ + +A+ ++GIP++ VE
Sbjct: 6   KQRQTWSSRLTYVMTVAGATVGFGATWRFPYLVGENGGGAYVLLFCIAMIVIGIPMILVE 65

Query: 69  WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
            V GR          G    ++ +     +   I G +G   AF     + +YY+ L GW
Sbjct: 66  NVIGRRLRVNSIDAFGDK--ILDKGKGISKYWKILGYMGLLGAFG----IMAYYMVLGGW 119

Query: 129 SAAYSWFSISGAY-----FNVESTAKFFESYLSNHGLVFLFWGITVVLL-AIAVGQGVSK 182
             +Y    ISG          +    F++ ++ N     +F+ +  V++  I + +G+  
Sbjct: 120 VISYIISLISGTLDISTPITKDIAKNFYDLHIGNSPYEIIFYTLLFVIVNYIILAKGIIG 179

Query: 183 GIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSV 242
           GIER VK +MPLL++F + +VI    L           ++G  F   P+++ +   L+  
Sbjct: 180 GIERSVKYLMPLLFIFLIGMVIRNVTLP--------GAMEGITFYLKPDFSKITPQLFIF 231

Query: 243 MLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAV 302
           +L   GQ+FF LSLG G++   +SYL  ++++  + + T   N    V+ G  I      
Sbjct: 232 VL---GQVFFALSLGFGVLITLSSYLNKEENLIHTAVITGFTNTIIAVLAGFMIF----- 283

Query: 303 AYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWF 362
                   P +   G       I  N G    + SLP +F  +  AG+FF  ++F LL  
Sbjct: 284 --------PSLFTFG-------IEPNAGPTLVFQSLPIVFSHL-WAGKFFAIIFFGLLLI 327

Query: 363 AGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLG-IPVV 406
           A  T++I +Y  +   L+E L + R     +     FLLG IP +
Sbjct: 328 AALTTSITIYEVIITALQEKLRMCRGKAIVLTLSGIFLLGNIPAI 372


>pir||B64582 sodium- and chloride-dependent transporter - Helicobacter pylori
           (strain 26695) >gi|2313608|gb|AAD07563.1| (AE000564)
           sodium- and chloride-dependent transporter [Helicobacter
           pylori 26695]
           Length = 442
           
 Score =  138 bits (345), Expect = 1e-31
 Identities = 129/477 (27%), Positives = 217/477 (45%), Gaps = 69/477 (14%)

Query: 16  TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
           +K+G ILA  G++IGLG+  RFP  V  NGG AF++ Y +    LGI ++ VE + G  G
Sbjct: 5   SKLGFILATLGSSIGLGHIWRFPYMVGHNGGSAFVLLYLVLTLSLGIAMLLVEMLIGNLG 64

Query: 76  GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
            K     +   + ++  +  K      F ++GG        L+ S+Y  ++GW   Y + 
Sbjct: 65  KK----DVVSNYQILDPKRKKYYPFTSFFILGG-------PLILSFYAVVLGWVLYYLFV 113

Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIA--VGQGVSKGIERWVKVMMP 193
                  ++E  AK   S L N  L++   G +  LL     V +G+ +GIE+   V+MP
Sbjct: 114 VTFDLPKDLEQ-AKMQFSMLQNGSLIWPVIGFSACLLPTIWFVSRGIEEGIEKLNVVLMP 172

Query: 194 LLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFT 253
           LL+V  + L+IY   L         S  K   F+++     +++  + V++ A GQ+FF+
Sbjct: 173 LLFVIFIGLLIYAMTLE--------SMPKALHFLFN---FEIQKIDFKVVMDALGQMFFS 221

Query: 254 LSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEV 313
           LSLG+G I  Y+++   K+++  S L  V       ++ G  I   +   +A        
Sbjct: 222 LSLGVGTIITYSAFTPKKENLFKSSLFIVLPGILISLIAGVMIFTFVFEYHAD------- 274

Query: 314 LAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYN 373
                      +S+  G G  + SLP  F +MG +G+     +F+ L FAG TS +++  
Sbjct: 275 -----------VSQ--GPGLVFISLPLTFAKMGMSGQIVSLFFFMALVFAGITSTVSLIE 321

Query: 374 YLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVY----------------INGYLDQVDA 417
            L   L      SR   +  + ++ ++LG+ V+                 + G+LD + +
Sbjct: 322 PLALYLINRFNFSRLQASLWIGVVVYVLGVLVILSMNERYAKFLSFAHKSVFGWLDFITS 381

Query: 418 WISFQLALLALFDIIVGVWLF-KPDNFWKELHEGALINVPEFYKWITVI--IAPIFI 471
             SF + L  LF ++   W+  K  +F    H     N   F  W   +  IAP+ I
Sbjct: 382 --SFLMPLGGLFSVLFIGWILNKKRSFLATKH---FFNANAFKAWHFSVRFIAPVVI 433


>pir||E81367 probable transmembrane transport protein Cj0934c [imported] -
           Campylobacter jejuni (strain NCTC 11168)
           >gi|6968371|emb|CAB73191.1| (AL139076) putative
           transmembrane transport protein [Campylobacter jejuni]
           Length = 446
           
 Score =  136 bits (340), Expect = 5e-31
 Identities = 120/464 (25%), Positives = 207/464 (43%), Gaps = 46/464 (9%)

Query: 16  TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
           +KIG +L +AG A+GLGN  +FPT  A NGG  F++ Y      +G  +   E   GR  
Sbjct: 6   SKIGFVLTVAGGAVGLGNAWKFPTLSAENGGFVFVLLYLFFTLTIGFSIFLAEVAMGRLS 65

Query: 76  GKYGHGTLGPTFYLMA-RESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSW 134
                  L   +  +A +   + R   +F ++GG           S+YL ++GW   Y+ 
Sbjct: 66  ----KSDLANAYSNLAIKYGNRWRYGGVF-MLGGIFVL-------SFYLVIMGWVLKYTV 113

Query: 135 FSISGAYFNVESTAKFFESYLSNH--GLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMM 192
            S+      ++  A  F++ ++ +    VF F+ ++  L  + V +G+ KGIE+   V+M
Sbjct: 114 VSLYYLPKTLDEAASNFQNLITTNLTSSVF-FFTLSFFLTLLIVSKGLIKGIEKLNVVIM 172

Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFF 252
           P L++  V ++ Y                  F +++ P++ + K   +S +  A G  FF
Sbjct: 173 PSLFLMLVFMLFYCMGFKQGFAN-------AFSYLFYPDFLHFK---FSSIAEALGLAFF 222

Query: 253 TLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPE 312
           TL LG+G I  Y+S L  K +   S +  V +N     ++G              IV   
Sbjct: 223 TLCLGIGCIVTYSSALDKKTNFIKSSVYIVLINLLISFIMG-------------LIVFTF 269

Query: 313 VLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMY 372
           +   G++   Q      G+G  + SL ++F Q+G  G  F   +FL L+FAG TSA++M 
Sbjct: 270 IFEFGADPHTQ------GVGIVFISLMSLFNQLGALGYIFAFCFFLALFFAGITSAVSMI 323

Query: 373 NYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALFDII 432
             LT  +  +  ISR    +++ +  F+ GI  + ++  L+    +  F      L D +
Sbjct: 324 EPLTFYMINNYQISRVKALFLIGLFVFVFGICCI-LSLNLNFFSMFSFFGKDFFTLLDKL 382

Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLF 476
              +L         +  G  +N  + YK  +  I+     + LF
Sbjct: 383 TSNFLLPLGAIVCSIFVGFFMNKKQIYKIFSKFISRKIFLIWLF 426


>dbj|BAA24689.1| (AB010832) putative tryptophan tranporter; similar to
           sodium-dependent neurotransmitter symporter familly
           (SNF) [Symbiobacterium thermophilum]
           Length = 500
           
 Score =  131 bits (325), Expect = 3e-29
 Identities = 129/489 (26%), Positives = 213/489 (43%), Gaps = 60/489 (12%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QRD+W ++ G I A  G A+GLGNF RFP     NGGGAF++PYF+AL   G+P+M +E 
Sbjct: 4   QRDQWKSRSGFIFATIGAAVGLGNFWRFPFMAYQNGGGAFLLPYFVALLTAGVPLMILE- 62

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
                   +G G    T  + A + L  R   I     G        ++ ++Y  +I WS
Sbjct: 63  --------FGFGHKMRTATITAFKKLNRRFEWI-----GWWQITVPVVVVTFYSVIISWS 109

Query: 130 AAYSWFSISGAYFNVESTAKFFES-YLSNHG----LVFLFWGITVVLLAI------AVGQ 178
             Y  FS + A+ +   T  FF S +L        L  L WGI   +  +         Q
Sbjct: 110 LRYLIFSFTQAWGDDPGT--FFSSDFLGITSGPLELGGLRWGIFAAVAVVWFANYYISAQ 167

Query: 179 GVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEH 238
           G+S GIE+  K+M P L V  +I VI    L             G  +  +P+++ + + 
Sbjct: 168 GISGGIEKACKIMTPFLIVAMLIFVIRGITLP--------GATYGLNYFLNPDFSKIMDP 219

Query: 239 LWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAV 298
              V +AA  Q+FF+ +L +G++  YASY+ P+     + L     N   + + G ++  
Sbjct: 220 --GVWVAAYSQVFFSTTLAVGVMIAYASYV-PETRTWPTTLHYRLRNSSFDFMAGLAVFS 276

Query: 299 PLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQM---GTAGRFFGAL 355
            L  A     VP E +A              G G ++ + P     +         FG L
Sbjct: 277 TLGYAAVTAGVPFEEMAVA------------GPGVAFVAFPKAISMLPGPTWLQSLFGIL 324

Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYING----Y 411
           +F  L  AG +S+I+      + + +  G+ RK       +I F      ++  G     
Sbjct: 325 FFSALLLAGISSSISQMESFASAVIDRFGVDRKKLLGWFSLIGF--AFSALFATGAGVHI 382

Query: 412 LDQVDAWI-SFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIF 470
           LD VD ++ S+ +A+L L + IV  ++       + ++  + I V  ++  +   + P+ 
Sbjct: 383 LDIVDHFVGSYAIAILGLVEAIVLGYIMGTARIREHVNLTSDIRVGMWWDVLVKYVTPVL 442

Query: 471 IALPLFGTF 479
           +   +   F
Sbjct: 443 LGYNILSNF 451


>pir||H81407 probable sodium-dependent transmembrane transport protein Cj0601c
           [imported] - Campylobacter jejuni (strain NCTC 11168)
           >gi|6968068|emb|CAB75237.1| (AL139075) putative
           sodium-dependent transmembrane transport protein
           [Campylobacter jejuni]
           Length = 447
           
 Score =  130 bits (324), Expect = 4e-29
 Identities = 133/488 (27%), Positives = 214/488 (43%), Gaps = 74/488 (15%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR  W++ +  IL +AG  IG G   RFP  V  NGGGA+++ + +A+ ++GIPV+ VE 
Sbjct: 2   QRQTWSSTLTYILTVAGATIGFGATWRFPYLVGENGGGAYVLVFCIAMIIIGIPVILVEN 61

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           V GR                      K +S    GL+G   +F     + +YY+ L GW 
Sbjct: 62  VIGRKAMTNSVDAF----------KQKWQSIGYMGLLG---SFG----IMAYYMVLGGWV 104

Query: 130 AAYSW------FSISGAYFNVESTAKFFESYLSNHGL-VFLFWGITVVLLAIAVGQGVSK 182
             Y W      FS++    + E T +FF   ++ + L V +F  + V++  I + +G+  
Sbjct: 105 LVYIWELTLGNFSLANV-VSKEFTHQFFNDKIAFNPLGVGIFTTVFVIINYIILKRGIID 163

Query: 183 GIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSV 242
           GIE+ VK +MPLL++  +I+V     L   +   ++     F  I SP           +
Sbjct: 164 GIEKSVKFLMPLLFICLIIVVGRNLTLDGAMAGVKFYLEPDFSKILSP----------KL 213

Query: 243 MLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAV 302
           ++   GQ+FF LSLG G++   +S+L   +++A + + T  LN    V+ G  I   L  
Sbjct: 214 LIDVLGQVFFALSLGFGVMITLSSHLNKNENMAKTAIYTGVLNTIIAVLAGFMIFPALFS 273

Query: 303 AYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWF 362
           A          LA  S  +L  + E   + FS+             G     L+F+LL  
Sbjct: 274 A---------GLAPDSGPSL--VFETLPIAFSHIHF----------GTIVCILFFVLLLI 312

Query: 363 AGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLG-IP----------VVYING- 410
           A  T+++ +Y  + ++LEE    S+     +     F+LG +P          +V I G 
Sbjct: 313 AALTTSLPIYQVIISVLEEKFKYSKNLSINLTLGFIFILGNLPCILTYGPWRDIVIIKGK 372

Query: 411 -YLDQVDAWISFQL--ALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVI-- 465
              D  D +IS  +   L A F  I   W+       KEL     +    F  W   +  
Sbjct: 373 NIFDSFD-FISGNILFVLTAFFCCIYVGWILGKQESLKELSNNNTLKSSWFGIWFYYVKY 431

Query: 466 IAPIFIAL 473
           I P+ I +
Sbjct: 432 IVPLIILI 439


>gb|AAF73566.1| (AE002319) sodium-dependent transporter, putative [Chlamydia
           muridarum]
           Length = 490
           
 Score =  123 bits (305), Expect = 6e-27
 Identities = 121/472 (25%), Positives = 206/472 (43%), Gaps = 54/472 (11%)

Query: 14  WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
           +++++G IL+M G AIG GN  RFP  VA NGGG+F++ + L L +  IP++ VE   G+
Sbjct: 8   FSSRLGFILSMMGVAIGAGNIWRFPRMVAQNGGGSFIILWLLFLLIWSIPLIIVELSLGK 67

Query: 74  YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
              K   GTL  T          P++A     +GG +    T +L  YY +++GW  +YS
Sbjct: 68  LTKKAPVGTLIRT--------AGPKAA----WLGGFVVLVATCIL-GYYSNIVGWGFSYS 114

Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWG---ITVVLLAIAVGQGVSKGIERWVKV 190
           ++++SG      S    F    +NH   ++      + + L    + +G+  GIE   K+
Sbjct: 115 FYALSGKI----SPGNNFPQLWANHCQSWMPLSCHCLALFLSYCVIRKGIVNGIESCNKI 170

Query: 191 MMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHL--WSVMLAASG 248
           ++PL  + +++L+    +L +      W  I+         + + KE L  + V + A  
Sbjct: 171 LIPLFCICSLVLLARAVSLPN-----AWEGIRLL-------FVFNKESLSNYKVWIEALT 218

Query: 249 QIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKI 308
           Q  +    G G++  YA +   +  +  +G  T   N     ++   +    A   + ++
Sbjct: 219 QNAWDTGAGWGLLLVYAGFTSKRTSLVTNGTITAVTNNLISFLMAVIVFSACASLDSTEM 278

Query: 309 VPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGF 365
           +    L +G  A+      N G+ F Y  LP +F ++  A      F A++FL    A  
Sbjct: 279 LG---LKEGVGAS------NIGMAFIY--LPELFTRLPQAHLLSTVFSAIFFLAFSMAAL 327

Query: 366 TSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLAL 425
           +S I+M   L+  L E  GI +        II FL+G+P      + D  D      L L
Sbjct: 328 SSMISMLFLLSQTLTE-FGIKKHIAESSATIIAFLIGVPSALSLKFFDNQDTVWGIALIL 386

Query: 426 LALFDIIVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFG 477
             +  I   +    P      L +  + +VP  YK        +   LPL G
Sbjct: 387 NGMIFIYAAISYGIP-----SLRKEVINSVPGDYKLKAYFDVLVKFLLPLEG 433


>gb|AAC46377.1| (AF017105) sodium-dependent transporter [Chlamydophila caviae]
           Length = 386
           
 Score =  121 bits (300), Expect = 2e-26
 Identities = 103/396 (26%), Positives = 189/396 (47%), Gaps = 43/396 (10%)

Query: 14  WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
           +++++G I +M G A+G GN  RFP   A NG GAF++ + L LF+  IP++ +E   G+
Sbjct: 8   FSSRLGFIFSMMGIAVGAGNIWRFPRIAAQNGNGAFILIWLLFLFIWSIPLIIIELSLGK 67

Query: 74  YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
                  GTL  T          P+ A     +GG +   TT +L +YY +++GW  +Y 
Sbjct: 68  LTKNAPIGTLIKT--------AGPKRA----WLGGFVTLVTTCIL-AYYSNIVGWGLSYF 114

Query: 134 WFSISGAYFNVESTAKFFES-YLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMM 192
           ++SISG  +   +  + +E+ Y S+  L+F F  +++ L  + + +G+ +GIE+  K+++
Sbjct: 115 YYSISGKIYAGNNFCQLWEAHYQSSFPLLFHF--LSLFLAYMIIRKGIVQGIEKCNKILI 172

Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEH-LWSVMLAASGQIF 251
           P   V  ++L++    L         + ++G + +++ ++  L  + LW   + A  Q  
Sbjct: 173 PSFCVCTLVLLVRAVTLP--------NAMQGIKQLFTFDFASLSSYKLW---IEALTQNA 221

Query: 252 FTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPP 311
           +    G G++  Y+ +   K  V  +G  T   N    +++G  +    A          
Sbjct: 222 WDTGAGWGLLLVYSGFASKKTGVVSNGALTAISNNXVSLIMGIIVFATCA---------- 271

Query: 312 EVLAKGSNAALQWISENFGLGFSYTSLPNIFVQM-GTA--GRFFGALWFLLLWFAGFTSA 368
             L    N  +      F    S+  LP +F ++ G+A     F +++FL    A  +S 
Sbjct: 272 -SLDVXRNNTVTTRCGFFKHRHSFYYLPELFTRVPGSAYLPAIFSSIFFLAFAMAALSSM 330

Query: 369 IAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP 404
           I+M   L+  L E  GI +    +   II F+LG+P
Sbjct: 331 ISMLFLLSQTLSE-FGIKKHVAEYSATIIAFILGVP 365


>pir||C71541 probable na-dependent transporter - Chlamydia trachomatis
           (serotype D, strain UW3/Cx) >gi|3328640|gb|AAC67823.1|
           (AE001296) Sodium-dependent amino acid transporter
           [Chlamydia trachomatis]
           Length = 490
           
 Score =  121 bits (300), Expect = 2e-26
 Identities = 120/471 (25%), Positives = 208/471 (43%), Gaps = 52/471 (11%)

Query: 14  WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
           +++++G IL+M G AIG GN  RFP  VA NGGG F++ + L L +  IP++ VE   G+
Sbjct: 8   FSSRLGFILSMMGVAIGAGNIWRFPRMVAQNGGGTFILLWLLFLIIWSIPLIIVELSIGK 67

Query: 74  YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
              K   G L  T          P+SA     +GG +    T +L  YY +++GW  +Y 
Sbjct: 68  LTRKAPIGALIRT--------AGPKSA----WLGGFIVLVATCIL-GYYSNIVGWGFSYF 114

Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIA---VGQGVSKGIERWVKV 190
           ++S+SG           F    ++H   ++      + L +A   + +G+  GIE   K+
Sbjct: 115 FYSLSGKIV----PGNHFPQLWAHHCQSWMPLSCHCLALFLAYCIIRKGIVNGIETCNKI 170

Query: 191 MMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQI 250
           ++P  ++ A++L+    +L        W   +G   ++  N   L +  + V + A  Q 
Sbjct: 171 LIPFFFICALVLLARAVSL-----PHAW---EGIRLLFVFNKASLCD--YKVWIEALTQN 220

Query: 251 FFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVP 310
            +    G G++  YA +   +  +  +G  T   N F   ++   +    A   + +++ 
Sbjct: 221 AWDTGAGWGLLLVYAGFASKQTSLVTNGAITAITNNFISFLMAVIVFSACASLDSTEMLG 280

Query: 311 PEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGFTS 367
              L +G  A+      N G+ F Y  LP +F ++  A     FF A++FL    A  +S
Sbjct: 281 ---LREGVGAS------NIGMAFIY--LPELFTRLPHAHILSTFFSAIFFLAFSMAALSS 329

Query: 368 AIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLA 427
            I+M   L+  L E  GI +        I  FL+G+P      + D  D      L L  
Sbjct: 330 MISMLFLLSQTLTE-FGIKKHIAESSATIAAFLIGVPSALNLQFFDNQDIVWGIALILNG 388

Query: 428 LFDIIVGVWLFKPDNFW-KELHEGALINVPEFYKWITVIIAPIFIALPLFG 477
           +      ++++   ++  K L +  + +VP  YK  T     +   LPL G
Sbjct: 389 M------IFIYSALSYGIKRLRQDVINSVPGDYKLKTYFDILVKFLLPLEG 433


>pir||F72095 na-dependent transporter - Chlamydophila pneumoniae (strain CWL029)
           >gi|4376565|gb|AAD18439.1| (AE001614) Na-dependent
           Transporter [Chlamydophila pneumoniae CWL029]
           Length = 494
           
 Score =  120 bits (298), Expect = 4e-26
 Identities = 99/395 (25%), Positives = 181/395 (45%), Gaps = 41/395 (10%)

Query: 14  WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
           +++++G I +M G A+G GN  RFP   A NGGGAF++ +   LFL  IP++ +E   G+
Sbjct: 8   FSSRLGFIFSMIGIAVGAGNIWRFPRVAAQNGGGAFLILWLCFLFLWSIPLIIIELSIGK 67

Query: 74  YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
              K   G L  T            +   F   GG +   TT +L +YY  ++GW  +Y 
Sbjct: 68  LTKKAPIGALIKT------------AGKKFAWAGGFITLVTTCIL-AYYSTIVGWGLSYF 114

Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLA-IAVGQGVSKGIERWVKVMM 192
           ++++SG        AK + S+  +   + L+  +T + LA + + +G+  GIE+  K+++
Sbjct: 115 YYAVSGKIHLGNDFAKLWTSHYQSS--IPLWAHLTSLGLAYLVIRKGIVHGIEKCNKILI 172

Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFF 252
           P  ++  + L++    L           ++G + ++S + +      + V + A  Q  +
Sbjct: 173 PAFFLCTIALLLRAVTLP--------GAVQGIKQLFSCDKSCFSN--YKVWIEALTQNAW 222

Query: 253 TLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPE 312
               G G++  YA +   K  V  +G  T   N    +++G    +  +   +  I+   
Sbjct: 223 DTGAGWGLLLVYAGFASKKTGVVSNGALTAICNNLVSLIMG---IIIFSTCASLDILGTT 279

Query: 313 VLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGFTSAI 369
            L  G+ A+         +G ++  LP +F ++         F +++FL    A  +S I
Sbjct: 280 QLQDGAGAS--------SIGITFIYLPELFTRLPGGIYLTTLFSSIFFLAFSMAALSSMI 331

Query: 370 AMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP 404
           +M   L+  L E  GI       +  II F+LGIP
Sbjct: 332 SMLFLLSQTLAE-FGIKPYISETLATIIAFVLGIP 365


>gb|AAF73672.1| (AE002208) sodium-dependent transporter, putative [Chlamydophila
           pneumoniae AR39] >gi|8978664|dbj|BAA98500.1| (AP002546)
           Na-dependent transporter [Chlamydophila pneumoniae J138]
           Length = 494
           
 Score =  120 bits (298), Expect = 4e-26
 Identities = 99/395 (25%), Positives = 181/395 (45%), Gaps = 41/395 (10%)

Query: 14  WATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGR 73
           +++++G I +M G A+G GN  RFP   A NGGGAF++ +   LFL  IP++ +E   G+
Sbjct: 8   FSSRLGFIFSMIGIAVGAGNIWRFPRVAAQNGGGAFLILWLCFLFLWSIPLIIIELSIGK 67

Query: 74  YGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYS 133
              K   G L  T            +   F   GG +   TT +L +YY  ++GW  +Y 
Sbjct: 68  LTKKAPIGALIKT------------AGKKFAWAGGFITLVTTCIL-AYYSTIVGWGLSYF 114

Query: 134 WFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLA-IAVGQGVSKGIERWVKVMM 192
           ++++SG        AK + S+  +   + L+  +T + LA + + +G+  GIE+  K+++
Sbjct: 115 YYAVSGKIHLGNDFAKLWTSHYQSS--IPLWAHLTSLGLAYLVIRKGIVHGIEKCNKILI 172

Query: 193 PLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFF 252
           P  ++  + L++    L           ++G + ++S + +      + V + A  Q  +
Sbjct: 173 PAFFLCTIALLLRAVTLP--------GAVQGIKQLFSCDKSCFSN--YKVWIEALTQNAW 222

Query: 253 TLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPE 312
               G G++  YA +   K  V  +G  T   N    +++G    +  +   +  I+   
Sbjct: 223 DTGAGWGLLLVYAGFASKKTGVVSNGALTAICNNLVSLIMG---IIIFSTCASLDILGTT 279

Query: 313 VLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA---GRFFGALWFLLLWFAGFTSAI 369
            L  G+ A+         +G ++  LP +F ++         F +++FL    A  +S I
Sbjct: 280 QLQDGAGAS--------SIGITFIYLPELFTRLPGGIYLTTLFSSIFFLAFSMAALSSMI 331

Query: 370 AMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIP 404
           +M   L+  L E  GI       +  II F+LGIP
Sbjct: 332 SMLFLLSQTLAE-FGIKPYISETLATIIAFVLGIP 365


>dbj|BAA89537.1| (AB006986) taurine transporter [Cyprinus carpio]
           Length = 625
           
 Score =  119 bits (295), Expect = 9e-26
 Identities = 131/509 (25%), Positives = 223/509 (43%), Gaps = 85/509 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KWA+K+  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G++  + G         +   E L P    IF  IG A +    +LLN YY+ ++ W 
Sbjct: 100 ALGQFTSEGG---------ITCWEKLCP----IFTGIGYA-SIVIVSLLNIYYIVILAWG 145

Query: 130 AAY---------------------------------SWFSISGAYFNVESTAKFFESYLS 156
             Y                                  W +++   F    T  +  + LS
Sbjct: 146 LYYLFQCFQPELPWASCNNKWNTENCIEDTLRKNKTLWGAVNATNFTSPVTEFWERNVLS 205

Query: 157 -NHGLV---FLFWGITVVLLAIAV--GQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
            + G+     + W + + LLA+ V     + KG++   KV+ +   + F +++V+ V  +
Sbjct: 206 ISDGIEDVGHVKWDLALCLLAVWVICFFCIWKGVKSTGKVVYVTATFPFVMLIVLLVRGV 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   PN T L +    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAAEGIKFYLYPNLTRLGDP--EVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     L    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNCYRDCLLLGGLNSATSFVSGFAIFSVLG-----------FMAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLE-----EDL 383
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++        
Sbjct: 366 GPGLAFIAYPKA-VSMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 384 GISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
           G  R+    IV  + +LLG+ +V   G Y+ Q+ D + +  + LL  A F+ I   W++ 
Sbjct: 425 GYRREIFIAIVCFLSYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
            DNF+  + E        + KW   +I P
Sbjct: 485 ADNFYDAIEEMIGYRPNPWMKWSWTVITP 513


>pir||A64582 sodium- and chloride-dependent transporter - Helicobacter pylori
           (strain 26695) >gi|2313607|gb|AAD07562.1| (AE000564)
           sodium- and chloride-dependent transporter [Helicobacter
           pylori 26695]
           Length = 442
           
 Score =  117 bits (290), Expect = 4e-25
 Identities = 103/392 (26%), Positives = 173/392 (43%), Gaps = 42/392 (10%)

Query: 16  TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
           +K+G +LA  G+AIGLG+  RFP     +GGGAF++ +      +G  +   E + G+  
Sbjct: 6   SKLGFVLAALGSAIGLGHIWRFPYMTGVSGGGAFVLLFLFLSLSVGAAMFIAEMLLGQ-- 63

Query: 76  GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
                 T            + P+    +      L   +  L+ ++Y  ++GW   Y   
Sbjct: 64  -----STQKNVTEAFKELDINPKKRWKYA----GLLLVSGPLILTFYGTILGWVLYYLVS 114

Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLL 195
                  N++ + + F   L + GL  +     +++    V +G+ +GIE+   V+MPLL
Sbjct: 115 VSFNLPNNIQESEQIFTQTLQSIGLQSIGLFSVLLITGWIVSRGIKEGIEKLNLVLMPLL 174

Query: 196 YVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLS 255
           +     L+ Y  ++ S      +S    F F + P     K+    V   + GQ+FF+LS
Sbjct: 175 FATFFGLLFYAMSMDS------FSKAFHFMFDFKP-----KDLTSQVFTYSLGQVFFSLS 223

Query: 256 LGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLA 315
           +G+GI   YA+      ++  S +          VVL G I + L    A  ++   V  
Sbjct: 224 IGLGINITYAAVTDKTQNLLKSTIW---------VVLSG-ILISLV---AGLMIFTFVFE 270

Query: 316 KGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL 375
            G+N +        G G  +TSLP +F QMG  G     L+ L L FAG TS +A+    
Sbjct: 271 YGANVSQ-------GTGLIFTSLPVVFGQMGAIGILVSILFLLALAFAGITSTVALLEPS 323

Query: 376 TALLEEDLGISRKTGTWIVFIIYFLLGIPVVY 407
              L E    SR   TW +  + F++G+ +++
Sbjct: 324 VMYLTERYQYSRFKVTWGLVALIFVVGVVLIF 355


>dbj|BAB18038.1| (AB033497) taurine transporter [Tilapia mossambica]
           Length = 629
           
 Score =  114 bits (282), Expect = 3e-24
 Identities = 129/510 (25%), Positives = 221/510 (43%), Gaps = 85/510 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KWA+K+  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 44  QREKWASKLDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 103

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y  + G         +     L P    IF  IG A +    +LLN YY+ ++ W 
Sbjct: 104 ALGQYTSEGG---------ITCWAKLCP----IFTGIGYA-SIVIVSLLNIYYIVILAWG 149

Query: 130 AAY---------------------------------SWFSISGAYFNVESTAKFFESYLS 156
             Y                                  W + +   F    T  +  + LS
Sbjct: 150 LYYLFQCFQPELPWAKCKQPWNTEHCVEDTVRKNKTLWLAANATNFTSPVTEFWERNVLS 209

Query: 157 ----NHGLVFLFWGITVVLLAIAV--GQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
                  +  L W + + LLA+ V     + KG++   KV+ +   + F +++V+ V  +
Sbjct: 210 ISTGIEDIGPLKWDLALCLLAVWVICFFCIWKGVKSTGKVVYITATFPFVMLIVLLVRGV 269

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   PN T L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 270 TLP------GAREGIKFYLYPNVTRLQDP--EVWIDAGTQIFFSYAICLGAMTSLGSYNK 321

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     L    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 322 YKYNCYRDCLLLGGLNSGTSFVSGFAIFSVLG-----------FMAQEQGVDIADVAES- 369

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M      +  L+F++L   G  S  + +   +T++++    + RK
Sbjct: 370 GPGLAFIAYPKA-VSMMPLPTLWAILFFIMLLLLGLDSQFVEVEGQITSIVDLYPAVLRK 428

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     + +LLG+ +V   G Y+ Q+ D + +  + LL  A F+ I   W++ 
Sbjct: 429 GYRREIFIAVMCFMSYLLGLAMVTKGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYG 488

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
            DNF+  + +        + KW   II P+
Sbjct: 489 VDNFYDAVEDMIGYRPNPWMKWSWSIITPV 518


>gi|6678223 taurine/beta-alanine transporter [Mus musculus]
           >gi|6019476|gb|AAB70922.2| (AF020194) retinal taurine
           transporter [Mus musculus]
           Length = 621
           
 Score =  114 bits (282), Expect = 3e-24
 Identities = 128/509 (25%), Positives = 220/509 (43%), Gaps = 85/509 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNVYYIVILAWA 145

Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
             Y                                  W S+S A F        E     
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205

Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
             S + N G +     + ++L+ +     + KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   P+ + L +    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     VLG +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVLGFAIFSILG-----------FMAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     I +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
            DN +  + +        + K+   +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513


>pir||F71930 probable transporter - Helicobacter pylori (strain J99)
           >gi|4154985|gb|AAD06027.1| (AE001479) putative
           transporter [Helicobacter pylori J99]
           Length = 442
           
 Score =  114 bits (282), Expect = 3e-24
 Identities = 101/392 (25%), Positives = 172/392 (43%), Gaps = 42/392 (10%)

Query: 16  TKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYG 75
           +K+G +LA  G+AIGLG+  RFP     +GGGAF++ +      +G  +   E + G+  
Sbjct: 6   SKLGFVLAALGSAIGLGHIWRFPYMTGVSGGGAFVLLFLFLSLSVGAAMFIAEMLLGQ-- 63

Query: 76  GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWF 135
                 T            + P+    +      +   +  L+ ++Y  ++GW   Y   
Sbjct: 64  -----STQKNVTEAFKELDINPKKRWKYA----GIMLISGPLILTFYGTILGWVLYYLVS 114

Query: 136 SISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLL 195
                  +++ + + F   L + GL  +     + +    V +G+ +GIE+   V+MPLL
Sbjct: 115 ISFNLPSSIQESEQIFTQTLQSIGLQSIGLFSVLFITGWIVSRGIKEGIEKLNLVLMPLL 174

Query: 196 YVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLS 255
           +     L+ Y  ++ S      +S    F F + P     K+    V   + GQ+FF+LS
Sbjct: 175 FATFFGLLFYAMSMDS------FSKAFHFMFDFKP-----KDLTSQVFTYSLGQVFFSLS 223

Query: 256 LGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLA 315
           +G+GI   YA+      ++  S +          VVL G I + L    A  ++   V  
Sbjct: 224 IGLGINITYAAVTDKTQNLLKSTIW---------VVLSG-ILISLV---AGLMIFTFVFE 270

Query: 316 KGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL 375
            G+N +        G G  +TSLP +F QMG  G     L+ L L FAG TS +A+    
Sbjct: 271 YGANVSQ-------GTGLIFTSLPVVFGQMGAIGVLVSILFLLALAFAGITSTVALLEPS 323

Query: 376 TALLEEDLGISRKTGTWIVFIIYFLLGIPVVY 407
              L E    SR   TW +  + F++G+ +++
Sbjct: 324 VMYLTEKYQYSRFKVTWGLVALIFVVGVVLIF 355


>gi|8394318 taurine/beta-alanine transporter [Rattus norvegicus]
           >gi|400635|sp|P31643|NTTA_RAT SODIUM- AND
           CHLORIDE-DEPENDENT TAURINE TRANSPORTER
           >gi|2119582|pir||I57939 taurine transporter - rat
           >gi|207542|gb|AAA42304.1| (M96601) taurine transporter
           [Rattus norvegicus]
           Length = 621
           
 Score =  113 bits (281), Expect = 4e-24
 Identities = 127/509 (24%), Positives = 220/509 (42%), Gaps = 85/509 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNVYYIVILAWA 145

Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
             Y                                  W S+S A F        E     
Sbjct: 146 TYYLFQSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSAANFTSPVIEFWERNVLS 205

Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
             S + + G +     + ++L+ +     + KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   PN + L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGEGIKFYLYPNISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     I +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAIVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
            DN +  + +        + K+   +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513


>sp|O35316|NTTA_MOUSE SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND BETA-ALANINE TRANSPORTER
           Length = 621
           
 Score =  113 bits (279), Expect = 7e-24
 Identities = 128/510 (25%), Positives = 217/510 (42%), Gaps = 87/510 (17%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNVYYIVILAWA 145

Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
             Y                                  W S+S A F        E     
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205

Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
             S + N G +     + ++L+ +     + KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   P+ + L +    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     VLG +I   L      + V               I+   
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVLGFAIFSILGFMAQEQGVD--------------IAAES 363

Query: 330 GLGFSYTSLPN-IFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISR 387
           G G ++ + P  + V M     F+  L+F++L   G  S  + +   +T+L++      R
Sbjct: 364 GPGLAFIAYPKAVDVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLR 423

Query: 388 KTGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLF 438
           K     +FI     I +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++
Sbjct: 424 KGYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIY 483

Query: 439 KPDNFWKELHEGALINVPEFYKWITVIIAP 468
             DN +  + +        + K+   +I P
Sbjct: 484 GGDNLYDGIEDMIGYRPGPWMKYSWAVITP 513


>gb|AAF76147.1|AF260239_1 (AF260239) taurine transporter [Bos taurus]
           Length = 620
           
 Score =  111 bits (276), Expect = 2e-23
 Identities = 127/510 (24%), Positives = 221/510 (42%), Gaps = 85/510 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KWA++I  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWASRIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFAGIGYA-SIVIVSLLNIYYIIILAWA 145

Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
             Y                                  W S S A F    T  +    LS
Sbjct: 146 MYYLFQSFQSELPWAKCNHSWNTPHCLEDTLRRNRSLWISNSTANFTSPVTEFWERKVLS 205

Query: 157 NHGLV----FLFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
               +     L W + + LL +       + KG++   KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDEPGALKWDLALCLLLVWLVCFFCIWKGVKSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P          G +F   P+ + L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGAGIKFYLYPDISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++    + RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLHPSLLRK 424

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     + +LLG+ +V   G Y+ Q+ D + +  + LL  A F+     W++ 
Sbjct: 425 GFHREIFIASICCVTYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFAIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
            DNF+  + +        + K+   ++ P+
Sbjct: 485 SDNFYDGIEDMIGYRPGPWMKYCWAVVTPL 514


>gb|AAF57986.1| (AE003806) DAT gene product [Drosophila melanogaster]
           Length = 576
           
 Score =  111 bits (276), Expect = 2e-23
 Identities = 130/538 (24%), Positives = 233/538 (43%), Gaps = 83/538 (15%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           ++R+ W+ K+  +L++ G A+ L N  RFP     NGGGAF+VPY + L + GIP+ ++E
Sbjct: 25  DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYME 84

Query: 69  WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
              G++  K      G             R   +F  IG A+       ++ YY  +I W
Sbjct: 85  LALGQHNRKGAITCWG-------------RLVPLFKGIGYAVVL-IAFYVDFYYNVIIAW 130

Query: 129 SAAYSWFSISGA--------YFNVESTAKFFESYLSN-------HGLVFLFWGITVVLLA 173
           S  + + S + +         +N  +       Y+         H L  + W + + LL 
Sbjct: 131 SLRFFFASFTNSLPWTSCNNIWNTPNCRPVTSRYILELNRSEGIHDLGAIKWDMALCLLI 190

Query: 174 IAVGQGVS--KGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSP 230
           + +    S  KGI    KV+    L+ +AV+L++ +  L  P       +  G ++  +P
Sbjct: 191 VYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLP------GSFLGIQYYLTP 244

Query: 231 NWTYL-KEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAE 289
           N++ + K  +W   + A+ Q+FF+L  G G++  YASY    ++V    L T  +N    
Sbjct: 245 NFSAIYKAEVW---VDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATS 301

Query: 290 VVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTA 348
            + G  I   L  +A+   +   +V  +G              G  +   P     M  A
Sbjct: 302 FIAGFVIFSVLGYMAHTLGVRIEDVATEGP-------------GLVFVVYPAAIATM-PA 347

Query: 349 GRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEEDLGISRKTGTWI--VFIIYFLLGIPV 405
             F+  ++F++L   G  S+       +TAL +E   I R    ++  +F +YF++G+  
Sbjct: 348 STFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLAS 407

Query: 406 VYINGY-----LDQVDAWISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYK 460
               G+     LD+  A  S  +A+   F+ I   W++  + F +++ +  +I  P    
Sbjct: 408 CTQGGFYFFHLLDRYAAGYSILVAV--FFEAIAVSWIYGTNRFSEDIRD--MIGFPPGRY 463

Query: 461 WITV--IIAPIFIA-LPLFG-------TFTDLV----SKTLGWPAKIAIIAMLIIGAI 504
           W      +APIF+  + ++G       T+ D V    +  LGW    + + M+   AI
Sbjct: 464 WQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAI 521


>pir||S46487 taurine transporter - human >gi|559853|gb|AAA50842.1| (U16120)
           placental taurine transporter [Homo sapiens]
           Length = 620
           
 Score =  110 bits (273), Expect = 3e-23
 Identities = 128/510 (25%), Positives = 223/510 (43%), Gaps = 85/510 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145

Query: 130 AAYSWFS----ISGAYFNVE-STAKFFESYLSNHGLVFL-------------FWGITVVL 171
             Y + S    +  A+ N   +T    E  +  +  V++             FW   V+ 
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205

Query: 172 LAIAVGQGVS---------------------KGIERWVKVM-MPLLYVFAVILVIYVFAL 209
           L+  +    S                     KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P          G +F   P+ T L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGAGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI +     +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
            DN +  + +        + K+   +I P+
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITPV 514


>gi|11433499 solute carrier family 6 (neurotransmitter transporter, taurine),
           member 6 [Homo sapiens]
           Length = 619
           
 Score =  110 bits (273), Expect = 3e-23
 Identities = 132/511 (25%), Positives = 223/511 (42%), Gaps = 87/511 (17%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145

Query: 130 AAYSWFS----ISGAYFNVE-STAKFFESYLSNHGLVFL-------------FWGITVVL 171
             Y + S    +  A+ N   +T    E  +  +  V++             FW   V+ 
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205

Query: 172 LAIAVGQGVS---------------------KGIERWVKVM-MPLLYVFAVILVIYVFAL 209
           L+  +    S                     KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P          G +F   P+ T L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGAGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     I +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHE--GALINVPEFYKWITVIIAP 468
            DN +  + +  G        Y W T  I+P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWATAPISP 515


>sp|P31641|NTTA_HUMAN SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER
           >gi|7441660|pir||G01426 taurine transporter - human
           >gi|799339|gb|AAC50443.1| (U09220) taurine transporter
           [Homo sapiens]
           Length = 620
           
 Score =  110 bits (273), Expect = 3e-23
 Identities = 128/510 (25%), Positives = 223/510 (43%), Gaps = 85/510 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145

Query: 130 AAYSWFS----ISGAYFNVE-STAKFFESYLSNHGLVFL-------------FWGITVVL 171
             Y + S    +  A+ N   +T    E  +  +  V++             FW   V+ 
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205

Query: 172 LAIAVGQGVS---------------------KGIERWVKVM-MPLLYVFAVILVIYVFAL 209
           L+  +    S                     KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P          G +F   P+ T L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGAGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI +     +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
            DN +  + +        + K+   +I P+
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITPV 514


>gi|4507045 solute carrier family 6 (neurotransmitter transporter, taurine),
           member 6; Solute carrier family 6 (neurotransmitter
           transporter, taurine), [Homo sapiens]
           >gi|346388|pir||S29839 taurine transport protein - human
           >gi|36727|emb|CAA79481.1| (Z18956) taurine transporter
           [Homo sapiens] >gi|266092|gb|AAB25509.1| taurine
           transporter, HTAU [human, thyroid cells, Peptide, 619
           aa]
           Length = 619
           
 Score =  110 bits (272), Expect = 5e-23
 Identities = 126/490 (25%), Positives = 215/490 (43%), Gaps = 85/490 (17%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEI 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SVVIVSLLNVYYIVILAWA 145

Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
             Y                                  W +IS   F       +  + LS
Sbjct: 146 TYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLS 205

Query: 157 -NHGLVF---LFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
            + G+     L W + + LL +       + KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSPGIDHPGSLKWDLALCLLLVWLVCFFCICKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   P+ T L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGRGIKFYLYPDITRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     I +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHE 449
            DN +  + +
Sbjct: 485 GDNLYDGIED 494


>sp|P31652|NTSE_RAT SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
           >gi|478853|pir||S30604 neurotransmitter transport
           protein - rat >gi|56780|emb|CAA45401.1| (X63995)
           neurotransmitter transporter [Rattus norvegicus]
           >gi|57743|emb|CAA44913.1| (X63253) serotonin transporter
           [Rattus rattus] >gi|1841938|emb|CAA71909.1| (Y11024)
           serotonin transporter [Rattus norvegicus]
           >gi|228364|prf||1803245A neurotransmitter transporter
           NTT [Rattus norvegicus]
           Length = 630
           
 Score =  109 bits (271), Expect = 6e-23
 Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           I+  +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ 
Sbjct: 74  IRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           ++E   G+Y   + +G +          S+  +   IF  IG A+       + SYY  +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179

Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
           I W+  Y                SW        F+     + + ST+   E YL +    
Sbjct: 180 IAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239

Query: 158 ------HGLVFLFWGIT--VVLLAIAVGQGVSKGIER-----WVKVMMPLLYVFAVILVI 204
                   L  + W +T  +VL+   +   + KG++      WV    P + V +V+LV 
Sbjct: 240 HQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298

Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
                G+      W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347

Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
           ASY    ++     L T  +N     V G  I   L             +A+  N  +  
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 396

Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
           ++++ G    + +       M  A  FF  ++FL+L   G  S  A +   +TA+L+E  
Sbjct: 397 VAKDAGPSLLFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455

Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
            I  K   W V I+    +LG  +   +G    V     +     +  +AL + +   W 
Sbjct: 456 HIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWF 515

Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
           +    F  ++ E    +   F++   V I+P+F+
Sbjct: 516 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 549


>pir||S19585 serotonin transport protein - rat >gi|228225|prf||1718346A
           serotonin transporter [Rattus rattus]
           Length = 607
           
 Score =  109 bits (271), Expect = 6e-23
 Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           I+  +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ 
Sbjct: 51  IRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 110

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           ++E   G+Y   + +G +          S+  +   IF  IG A+       + SYY  +
Sbjct: 111 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 156

Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
           I W+  Y                SW        F+     + + ST+   E YL +    
Sbjct: 157 IAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 216

Query: 158 ------HGLVFLFWGIT--VVLLAIAVGQGVSKGIER-----WVKVMMPLLYVFAVILVI 204
                   L  + W +T  +VL+   +   + KG++      WV    P + V +V+LV 
Sbjct: 217 HQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 275

Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
                G+      W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +
Sbjct: 276 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 324

Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
           ASY    ++     L T  +N     V G  I   L             +A+  N  +  
Sbjct: 325 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 373

Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
           ++++ G    + +       M  A  FF  ++FL+L   G  S  A +   +TA+L+E  
Sbjct: 374 VAKDAGPSLLFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 432

Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
            I  K   W V I+    +LG  +   +G    V     +     +  +AL + +   W 
Sbjct: 433 HIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWF 492

Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
           +    F  ++ E    +   F++   V I+P+F+
Sbjct: 493 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 526


>pir||A47194 taurine and beta-alanine transporter, TAUT - mouse
           Length = 590
           
 Score =  109 bits (270), Expect = 8e-23
 Identities = 126/509 (24%), Positives = 218/509 (42%), Gaps = 85/509 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  I  A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIAYA-SIVIVSLLNVYYIVILAWA 145

Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
             Y                                  W S+S A F        E     
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205

Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
             S + N G +     + ++L+ +     + KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   P+ + L +    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     I +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
            DN +  + +        + K+   +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513


>sp|P31642|NTTA_MUSCO SODIUM- AND CHLORIDE-DEPENDENT TAURINE AND BETA-ALANINE TRANSPORTER
           >gi|2078449|gb|AAB54039.1| (L03292) taurine/beta-alanine
           transporter [Mus cookii]
           Length = 621
           
 Score =  109 bits (270), Expect = 8e-23
 Identities = 126/509 (24%), Positives = 218/509 (42%), Gaps = 85/509 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  I  A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIAYA-SIVIVSLLNVYYIVILAWA 145

Query: 130 AAY---------------------------------SWFSISGAYFNV------ESTAKF 150
             Y                                  W S+S A F        E     
Sbjct: 146 TYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLS 205

Query: 151 FESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
             S + N G +     + ++L+ +     + KG+    KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P         +G +F   P+ + L +    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGEGIKFYLYPDISRLGDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILG-----------FMAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRK 424

Query: 389 TGTWIVFI-----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI     I +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAP 468
            DN +  + +        + K+   +I P
Sbjct: 485 GDNLYDGIEDMIGYRPGPWMKYSWAVITP 513


>sp|Q00589|NTTA_CANFA SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER
           >gi|290092|gb|AAA30876.1| (M95495) Na/Cl-dependent
           taurine transporter [Canis familiaris]
           Length = 620
           
 Score =  109 bits (269), Expect = 1e-22
 Identities = 125/510 (24%), Positives = 221/510 (42%), Gaps = 85/510 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNIYYVIILAWA 145

Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
             Y                                  W ++S   F    T  +  + LS
Sbjct: 146 TYYLFQSFQSELPWAHCNHSWNTPQCMEDTMRKNKSLWITLSTKNFTSPVTEFWERNVLS 205

Query: 157 NHGLV----FLFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
               +     L W + + LL +       + KG++   KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDDPGSLKWDLALCLLLVWLVCFFCIWKGVKSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P          G +F   P+ + L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGAGIKFYLYPDISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQVTSLVDLYPSFLRK 424

Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI +     +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GFRREIFIAFMCSISYLLGLSMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
            DN +  + +        + K+   ++ P+
Sbjct: 485 SDNLYDGIEDMIGYRPGPWMKYSWAVVTPV 514


>pir||A46270 Na and Cl dependent taurine transporter - dog
           Length = 655
           
 Score =  109 bits (269), Expect = 1e-22
 Identities = 125/510 (24%), Positives = 221/510 (42%), Gaps = 85/510 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           QR+KW++KI  +L++AG  +GLGN  RFP     NGGGAF++PYF+ LF  G+PV ++E 
Sbjct: 40  QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEV 99

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
           + G+Y  + G         +   E + P    +F  IG A +    +LLN YY+ ++ W+
Sbjct: 100 IIGQYTSEGG---------ITCWEKICP----LFSGIGYA-SIVIVSLLNIYYVIILAWA 145

Query: 130 AAYS---------------------------------WFSISGAYFNVESTAKFFESYLS 156
             Y                                  W ++S   F    T  +  + LS
Sbjct: 146 TYYLFQSFQSELPWAHCNHSWNTPQCMEDTMRKNKSLWITLSTKNFTSPVTEFWERNVLS 205

Query: 157 NHGLV----FLFWGITVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFAL 209
               +     L W + + LL +       + KG++   KV+     + FA++LV+ V  L
Sbjct: 206 LSSGIDDPGSLKWDLALCLLLVWLVCFFCIWKGVKSTGKVVYFTATFPFAMLLVLLVRGL 265

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
             P          G +F   P+ + L++    V + A  QIFF+ ++ +G + +  SY  
Sbjct: 266 TLP------GAGAGIKFYLYPDISRLEDP--QVWIDAGTQIFFSYAICLGAMTSLGSYNK 317

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
            K +     +    LN     V G +I   L             +A+     +  ++E+ 
Sbjct: 318 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGF-----------MAQEQGVDIADVAES- 365

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M     F+  L+F++L   G  S  + +   +T+L++      RK
Sbjct: 366 GPGLAFIAYPKA-VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQVTSLVDLYPSFLRK 424

Query: 389 TGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
                +FI +     +LLG+ +V   G Y+ Q+ D + +  + LL  A F+  V  W++ 
Sbjct: 425 GFRREIFIAFMCSISYLLGLSMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYG 484

Query: 440 PDNFWKELHEGALINVPEFYKWITVIIAPI 469
            DN +  + +        + K+   ++ P+
Sbjct: 485 SDNLYDGIEDMIGYRPGPWMKYSWAVVTPV 514


>sp|Q60857|NTSE_MOUSE SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
           >gi|2338560|gb|AAB67172.1| (AF013604) serotonin
           transporter [Mus musculus]
           Length = 630
           
 Score =  108 bits (268), Expect = 1e-22
 Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           I   +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ 
Sbjct: 74  IHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           ++E   G+Y   + +G +          S+  +   IF  IG A+       + SYY  +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179

Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
           I W+  Y                SW        F+     + + ST+   E YL +    
Sbjct: 180 IAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239

Query: 158 ------HGLVFLFWGITVVLLAI------AVGQGV-SKGIERWVKVMMPLLYVFAVILVI 204
                   L  + W + + ++ I      ++ +GV + G   WV    P + V +V+LV 
Sbjct: 240 HQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298

Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
                G+      W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347

Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
           ASY    ++     L T  +N     V G  I   L             +A+  N  +  
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 396

Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
           ++++ G    + +       M  A  FF  ++FL+L   G  S  A +   +TA+L+E  
Sbjct: 397 VAKDAGPSLLFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455

Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
            I  K   W V I+    +LG  +   +G    V     +     +  +AL + +V  W 
Sbjct: 456 HIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWF 515

Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
           +    F  ++ E    +   F++   V I+P+F+
Sbjct: 516 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 549


>gb|AAD26262.1|AF119122_1 (AF119122) serotonin transporter [Bos taurus]
           Length = 630
           
 Score =  108 bits (268), Expect = 1e-22
 Identities = 125/511 (24%), Positives = 213/511 (41%), Gaps = 88/511 (17%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ WA K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ ++E 
Sbjct: 78  ERETWAKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y   + +G +          S+  +   IF  IG A+       + SYY  +I W+
Sbjct: 138 ALGQY---HRNGCI----------SIWTKICPIFKGIGCAICL-IAFYIASYYNTIIAWA 183

Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESYLSN-------- 157
             Y                SW        FS     + + ST+   E Y  +        
Sbjct: 184 LYYLISSFTEQLPWTSCENSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 243

Query: 158 --HGLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
               L  L W + + ++ I   +   + KG++   KV+  +   F  I+++ +   G+ L
Sbjct: 244 GLQDLGGLSWQLVLCIMFIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILLILLVRGATL 302

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
               W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +ASY    ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNN 356

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
                L T ++N     V G  I   L      +      +AK +  +L +I+       
Sbjct: 357 CYQDALVTSAVNCMTSFVSGFVIFTVLGYMAEMRKEDVSEVAKDAGPSLLFIT----YAE 412

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISRKTGTW 392
           +  ++P        A  FF  ++FL+L   G  S  A +   +TA+L+E   +  K   W
Sbjct: 413 AIANMP--------ASTFFAIVFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRREW 464

Query: 393 IVFIIYFLLGIPVVYINGYLDQVDAWISFQLALL------------ALFDIIVGVWLFKP 440
                 F+LG+ +    G L  +    ++ + LL            AL + +   W +  
Sbjct: 465 ------FVLGVVITCFFGSLVTLTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGI 518

Query: 441 DNFWKELHEGALINVPEFYKWITVIIAPIFI 471
           + F  ++ E    +   F+K   V I+P+F+
Sbjct: 519 NQFCSDVKEMLGFSPGWFWKICWVAISPLFL 549


>gi|8394200 GABA transporter [Rattus norvegicus] >gi|881598|gb|AAC52867.1|
           (U28927) Na+/Cl- betaine/GABA transporter [Rattus
           norvegicus]
           Length = 628
           
 Score =  108 bits (267), Expect = 2e-22
 Identities = 124/490 (25%), Positives = 206/490 (41%), Gaps = 81/490 (16%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           Q++ R +W  K+  +L++AG  IGLGN  RFP     NGGGAF +PYF+  F  GIPV +
Sbjct: 46  QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFF 105

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
           +E   G+Y  +           + A   + P   L+ G+  G  +    + LN YY+ ++
Sbjct: 106 LEVALGQYSSQGS---------VTAWRKICP---LLQGI--GMASVVIESYLNIYYIIIL 151

Query: 127 GWSAAYSWFSISGA-----------------YFNVEST--AKFFESYLSN---------- 157
            W+  Y + S +                   + N  ST  A + E++ S           
Sbjct: 152 AWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVL 211

Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFAL 209
                 H L  L W + + LL   I     + KG++   KV+      F  +++I +   
Sbjct: 212 GITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY-FTATFPYLMLIILLIR 270

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
           G  L        +G  F   P+   LK+    V + A  QIFF+ ++  G +    SY  
Sbjct: 271 GVTLP----GAYQGIVFYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYNK 324

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
             ++     +A   LN     V G  +   L      + VP   +A+             
Sbjct: 325 YHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAES------------ 372

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M    + +  L+FL+L F G  S  + M   +TA ++      RK
Sbjct: 373 GPGLAFIAFPKA-VTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRK 431

Query: 389 TGT-----WIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
            G        V I+ +L+G+ +V   G Y+ Q+ D + S  + LL  +LF++I   W++ 
Sbjct: 432 RGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYG 491

Query: 440 PDNFWKELHE 449
            D F+  + +
Sbjct: 492 ADRFYDNVED 501


>sp|P48056|NTBE_RAT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
           (NA+/CL-BETAINE/GABA TRANSPORTER)
           Length = 614
           
 Score =  108 bits (267), Expect = 2e-22
 Identities = 124/490 (25%), Positives = 206/490 (41%), Gaps = 81/490 (16%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           Q++ R +W  K+  +L++AG  IGLGN  RFP     NGGGAF +PYF+  F  GIPV +
Sbjct: 32  QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFF 91

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
           +E   G+Y  +           + A   + P   L+ G+  G  +    + LN YY+ ++
Sbjct: 92  LEVALGQYSSQGS---------VTAWRKICP---LLQGI--GMASVVIESYLNIYYIIIL 137

Query: 127 GWSAAYSWFSISGA-----------------YFNVEST--AKFFESYLSN---------- 157
            W+  Y + S +                   + N  ST  A + E++ S           
Sbjct: 138 AWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVL 197

Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFAL 209
                 H L  L W + + LL   I     + KG++   KV+      F  +++I +   
Sbjct: 198 GITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY-FTATFPYLMLIILLIR 256

Query: 210 GSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLG 269
           G  L        +G  F   P+   LK+    V + A  QIFF+ ++  G +    SY  
Sbjct: 257 GVTLP----GAYQGIVFYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYNK 310

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
             ++     +A   LN     V G  +   L      + VP   +A+             
Sbjct: 311 YHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAES------------ 358

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRK 388
           G G ++ + P   V M    + +  L+FL+L F G  S  + M   +TA ++      RK
Sbjct: 359 GPGLAFIAFPKA-VTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRK 417

Query: 389 TGT-----WIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFK 439
            G        V I+ +L+G+ +V   G Y+ Q+ D + S  + LL  +LF++I   W++ 
Sbjct: 418 RGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYG 477

Query: 440 PDNFWKELHE 449
            D F+  + +
Sbjct: 478 ADRFYDNVED 487


>gi|7110639 5-hydroxytryptamine (serotonin) transporter [Mus musculus]
           >gi|1771316|emb|CAA70092.1| (Y08870) serotonin
           transporter [Mus musculus]
           Length = 630
           
 Score =  107 bits (265), Expect = 3e-22
 Identities = 126/514 (24%), Positives = 211/514 (40%), Gaps = 86/514 (16%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           I   +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ 
Sbjct: 74  IHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           ++E   G+Y   + +G +          S+  +   IF  IG A+       + SYY  +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179

Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
           I W+  Y                SW        F+     + + ST+   E YL +    
Sbjct: 180 IAWALYYLISSFTDQLQWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239

Query: 158 ------HGLVFLFWGITVVLLAI------AVGQGV-SKGIERWVKVMMPLLYVFAVILVI 204
                   L  + W + + ++ I      ++ +GV + G   WV    P + V +V+LV 
Sbjct: 240 HQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298

Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
                G+      W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347

Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
           ASY    ++     L T  +N     V G  I   L             +A+  N  +  
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSE 396

Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
           ++++ G    + +       M  A  FF  ++FL+L   G  S  A +   +TA+L+E  
Sbjct: 397 VAKDAGPSLLFITYAEAIRNM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455

Query: 384 GISRKTGTWIVFIIYF--LLGIPVVYINGYLDQVDAWISF----QLALLALFDIIVGVWL 437
            I  K   W V I+    +LG  +   +G    V     +     +  +AL + +V  W 
Sbjct: 456 HIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWF 515

Query: 438 FKPDNFWKELHEGALINVPEFYKWITVIIAPIFI 471
           +    F  ++ E    +   F++   V I+P+F+
Sbjct: 516 YGITQFCSDVKEMLGFSPGWFWRICWVAISPLFL 549


>pir||S63539 GABA/beta-alanine transporter - marbled electric ray
           >gi|1171630|emb|CAA60635.1| (X87170) GABA/beta-alanine
           transporter [Torpedo marmorata]
           Length = 622
           
 Score =  106 bits (261), Expect = 9e-22
 Identities = 141/582 (24%), Positives = 243/582 (41%), Gaps = 109/582 (18%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           +M +R  W  KI  +L++AG  IGLGN  RFP     NGGGAF++PY +     GIPV +
Sbjct: 34  RMSERGHWNNKIEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVIFFIGCGIPVFF 93

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYL 123
           +E   G+Y  + G         +     + P    +F  IG    +AT  +   LN +Y+
Sbjct: 94  LETALGQYTSEGG---------ITCWRKICP----LFEGIG----YATQVIEAHLNMFYI 136

Query: 124 HLIGWSAAYSW--------FSISGAYFNVESTAKF--FESYLSNHGLV-------FLFWG 166
            ++ W+  Y +        ++  G Y+N E+  +F    S   NH  V         FW 
Sbjct: 137 IVLAWAIFYLFNCFTSELPWATCGHYWNTENCLEFQKLNSTNCNHTAVPNATSPVIEFWE 196

Query: 167 ITVVLLAIAVGQGVSKGIE-----RWVKVMMPLLYVFAVIL------------VIYVFAL 209
             V+        G+S+GIE     RW ++ + LL  + +              V+YV A 
Sbjct: 197 RRVL--------GLSRGIEHIGRVRW-ELALCLLAAWIICYFCIWKGPKSTGKVVYVTAT 247

Query: 210 GSPL--------GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGII 261
              L        G       +G +F   P+ + L +    V L A  QIFF+ ++ +G +
Sbjct: 248 FPYLMLLVLLIRGVTLPGAAEGIKFYLYPDVSRLSDP--QVWLDAGTQIFFSYAICLGCL 305

Query: 262 QNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAA 321
               SY    ++     +    LN     V G +I   L      + VP   +A+     
Sbjct: 306 TALGSYNPYHNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAFEQGVPIAEVAES---- 361

Query: 322 LQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLE 380
                   G G ++ + P     M  A   +  L+FL+L F G  S  + M + +TA+++
Sbjct: 362 --------GPGLTFIAYPKAVTMMPLA-PLWAFLFFLMLIFLGLDSQFVCMESLVTAIID 412

Query: 381 E-----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDI 431
                   G  R+   +++ +  +L+G+ +V   G Y+ Q+ DA+ S  + LL  A+F+ 
Sbjct: 413 MYPSIFRRGYRREQLIFVIALASYLMGLVMVTEGGMYIFQLFDAYASSGMCLLFVAIFEC 472

Query: 432 IVGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP-IFIALPLFGTFTDLVSK----- 485
           I   W++  + F+  + +          KW  + I P I  A+ +F        K     
Sbjct: 473 ICIGWVYGGNRFYDNIEDMIGYRPFVLIKWCWIFITPGICAAIFIFFIVRYQPLKYNNVY 532

Query: 486 -------TLGWPAKIAIIAMLIIGAIEAYYAIKKKYGEELEK 520
                   LGW   ++ +  + +G I   ++ +  + E+++K
Sbjct: 533 VYPDWGYALGWALALSSMICIPLGFIFKMWSTEGTFLEKIKK 574


>sp|P31651|NTBE_MOUSE SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
           (NA+/CL-BETAINE/GABA TRANSPORTER) (SODIUM- AND
           CHLORIDE-DEPENDENT GABA TRANSPORTER 2) (GAT2)
           >gi|346711|pir||A43390 gamma-aminobutyric acid
           transporter protein GAT2 - mouse
           Length = 614
           
 Score =  105 bits (259), Expect = 2e-21
 Identities = 122/494 (24%), Positives = 207/494 (41%), Gaps = 81/494 (16%)

Query: 3   RGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGI 62
           +G  Q++ R +W  K+  +L++AG  IGLGN  RFP     NGGGAF +PYF+  F  GI
Sbjct: 28  KGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGI 87

Query: 63  PVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYY 122
           PV ++E   G+Y  +           + A   + P   L+ G+  G  +    + LN YY
Sbjct: 88  PVFFLEVALGQYSSQGS---------VTAWRKICP---LLQGI--GMASVVIESYLNIYY 133

Query: 123 LHLIGWSAAYSWFSISGAY--------FNVESTAKFF-----------ESYLSN------ 157
           + ++ W+  Y + S +           +N E    F            E++ S       
Sbjct: 134 IIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWE 193

Query: 158 ----------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVMMPLLYVFAVILVIY 205
                     H L  L W + + LL   I     + KG++   KV+      F  +++I 
Sbjct: 194 RRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY-FTATFPYLMLII 252

Query: 206 VFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYA 265
           +   G  L        +G  F   P+   LK+    V + A  QIFF+ ++  G +    
Sbjct: 253 LLIRGVTLP----GAYQGIVFYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALG 306

Query: 266 SYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWI 325
           SY    ++     +A   LN     V G  +   L      + +P   +A+         
Sbjct: 307 SYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAES-------- 358

Query: 326 SENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLG 384
               G G ++ + P   V M    + +  L+F++L F G  S  + M   +TA ++    
Sbjct: 359 ----GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQ 413

Query: 385 ISRKTGTWIVFIIY-----FLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGV 435
             RK+G   V I+      +L+G+ +V   G Y+ Q+ D + S  + LL  +LF++I   
Sbjct: 414 QLRKSGRRDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIG 473

Query: 436 WLFKPDNFWKELHE 449
           W++  D F+  + +
Sbjct: 474 WVYGADRFYDNVED 487


>gi|6981554 solute carrier family 6 (neurotransmitter transporter, serotonin),
           member 4  (5-hydroxytryptamine (serotonin) transporter)
           [Rattus norvegicus] >gi|207087|gb|AAA42186.1| (M79450)
           serotonin transporter [Rattus norvegicus]
           Length = 653
           
 Score =  105 bits (259), Expect = 2e-21
 Identities = 114/434 (26%), Positives = 182/434 (41%), Gaps = 80/434 (18%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           I+  +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ 
Sbjct: 74  IRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLF 133

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           ++E   G+Y   + +G +          S+  +   IF  IG A+       + SYY  +
Sbjct: 134 YMELALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTI 179

Query: 126 IGWSAAY----------------SW--------FSISGAYFNVESTAKFFESYLSN---- 157
           I W+  Y                SW        F+     + + ST+   E YL +    
Sbjct: 180 IAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQI 239

Query: 158 ------HGLVFLFWGIT--VVLLAIAVGQGVSKGIER-----WVKVMMPLLYVFAVILVI 204
                   L  + W +T  +VL+   +   + KG++      WV    P + V +V+LV 
Sbjct: 240 HQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVR 298

Query: 205 YVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNY 264
                G+      W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +
Sbjct: 299 GATLPGA------W---RGVVFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAF 347

Query: 265 ASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW 324
           ASY    ++     L T  +N     V G  I   L      +      +AK +  +L +
Sbjct: 348 ASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLF 407

Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDL 383
           I+    +G    ++P        A  FF  ++FL+L   G  S  A +   +TA+L+E  
Sbjct: 408 ITYAEAIG----NMP--------ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFP 455

Query: 384 GISRKTGTWIVFII 397
            I  K   W V I+
Sbjct: 456 HIWAKRREWFVLIV 469


>gb|AAC05185.1| (AF049108) GABA transporter [Raja sp.]
           Length = 598
           
 Score =  104 bits (258), Expect = 2e-21
 Identities = 117/483 (24%), Positives = 197/483 (40%), Gaps = 82/483 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+KW  K   +L+  G AIGLGN  RFP     NGGGAF++PYFL L   G+P+  +E 
Sbjct: 42  EREKWGGKYEFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGMPIFLLEC 101

Query: 70  VQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
             G+Y   G  G   L P F  +             GL    L+F     LN YY+ +I 
Sbjct: 102 SLGQYTSVGGLGIWRLAPMFKGV-------------GLAAAVLSF----WLNIYYVVIIA 144

Query: 128 WSAAY---------SWFSISGAYFNVESTAKFFESYLSNH-GLVFLFW------------ 165
           W+  Y          W S   A+     ++ +  S  +N    +  FW            
Sbjct: 145 WAIYYLYNSFTSELPWQSCGNAWNTERCSSNYSMSNTTNFTNPIVEFWERNMHQLSDGLD 204

Query: 166 ---------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQP 216
                     IT+ +  + V   + KG+  W   ++    ++  I+++ +F  G  L   
Sbjct: 205 QPGQIRAPLAITLAIAWVLVYFCIWKGVS-WTGKVVYFSAIYPYIMLLTLFFRGVTLPGA 263

Query: 217 QWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL 276
           +    +G  F  +P+++ L +    V L A+ QIFF+  LG+G +    SY    +++  
Sbjct: 264 R----EGILFYITPDFSRLTDS--EVWLDAATQIFFSYGLGLGSLVALGSYNTFHNNIYR 317

Query: 277 SGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSY 335
             +    +N    +  G  I ++   +A+       +V A G              G ++
Sbjct: 318 DSIIVCCINSTTSMFAGFVIFSIVGFMAHVTNRPIADVAASGP-------------GLAF 364

Query: 336 TSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKTGT 391
            + P    Q+     F+  L+F +L   G  S    +  ++TAL++E    L   R+   
Sbjct: 365 LAYPEAVTQL-PISPFWSILFFSMLLMLGIDSQFCTVEGFITALVDEFPKLLRGRREIFI 423

Query: 392 WIVFIIYFLLGIPVV-----YINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFWKE 446
            +V II +L+G+  +     Y+    D   A     L  L  F+ I   W +  + F+  
Sbjct: 424 AVVCIISYLIGLSNITQGGLYVFKLFDYYSA-SGMSLLFLVFFETISISWCYGVNRFFGN 482

Query: 447 LHE 449
           + E
Sbjct: 483 IEE 485


>gb|AAF97247.1|AF285761_1 (AF285761) serotonin transporter [Macaca mulatta]
           Length = 630
           
 Score =  104 bits (258), Expect = 2e-21
 Identities = 119/505 (23%), Positives = 210/505 (41%), Gaps = 76/505 (15%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ ++E 
Sbjct: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMEL 137

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y   + +G +          S+  +   IF  IG A+       + SYY  ++ W+
Sbjct: 138 ALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTIMAWA 183

Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESY----------- 154
             Y                SW        FS     + + ST+   E Y           
Sbjct: 184 LYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 243

Query: 155 -LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
            L + G +     + ++L+   +   + KG++   KV+  +   F  I++  +   G+ L
Sbjct: 244 GLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILSVLLVRGATL 302

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
               W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +ASY    ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNN 356

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
                L T  +N     V G  I   L             +A+  N  +  ++++ G   
Sbjct: 357 CYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSEVAKDAGPSL 405

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISRKTGTW 392
            + +       M  A  FF  ++FL+L   G  S  A +   +TA+L+E   I  K   W
Sbjct: 406 LFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREW 464

Query: 393 IVFII----YFLLGIPVVYINGYLDQVDAWISFQLALL--ALFDIIVGVWLFKPDNFWKE 446
            V  +    +F   + + +   Y+ ++    +   A+L  AL + +   W +    F ++
Sbjct: 465 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRD 524

Query: 447 LHEGALINVPEFYKWITVIIAPIFI 471
           + E    +   F++   V I+P+F+
Sbjct: 525 VKEMLGFSPGWFWRICWVAISPLFL 549


>gi|4507039 solute carrier family 6 (neurotransmitter transporter, GABA),
           member 1 [Homo sapiens] >gi|266666|sp|P30531|NTG1_HUMAN
           SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
           >gi|106051|pir||S11073 gamma-aminobutyric acid transport
           protein - human >gi|31658|emb|CAA38484.1| (X54673) GABA
           transporter [Homo sapiens]
           Length = 599
           
 Score =  104 bits (257), Expect = 3e-21
 Identities = 134/572 (23%), Positives = 227/572 (39%), Gaps = 93/572 (16%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           +  RD W  +   +++  G AIGLGN  RFP     NGGGAF++PYFL L   G+P+  +
Sbjct: 41  LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100

Query: 68  EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           E   G+Y   G  G   L P F  +             GL    L+F     LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWKLAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143

Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
           I W+  Y + S +         N  +T + F +Y      +    V  FW          
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDG 203

Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
                       IT+ +  I V   + KG+  W   ++     +  I++I +F  G  L 
Sbjct: 204 LDKPGQIRWPLAITLAIAWILVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 262

Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
             +    +G  F  +PN+  L +    V L A+ QIFF+  LG+G +    SY    ++V
Sbjct: 263 GAK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNV 316

Query: 275 ALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
               +    +N    +  G  I ++   +A+  K    +V A G              G 
Sbjct: 317 YRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GL 363

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKT 389
           ++ + P    Q+      +  L+F +L   G  S    +  ++TAL++E    L   R+ 
Sbjct: 364 AFLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRREL 422

Query: 390 GTWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFW 444
               V II +L+G+       +Y+    D   A     L  L  F+ +   W +  + F+
Sbjct: 423 FIAAVCIISYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFY 481

Query: 445 KELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----A 494
             + E        ++K       PI +A     +   +   T+G      W   +    A
Sbjct: 482 DNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMA 541

Query: 495 IIAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
           + +M++I    AY  +  K G   ++ +V+++
Sbjct: 542 LSSMVLIPGYMAYMFLALK-GSLKQRIQVMVQ 572


>sp|O35899|NTSE_CAVPO SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
           >gi|2584855|gb|AAB82737.1| (U84498) transmembrane 5-HT
           transporter [Cavia porcellus]
           Length = 630
           
 Score =  104 bits (256), Expect = 3e-21
 Identities = 123/510 (24%), Positives = 210/510 (41%), Gaps = 86/510 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ ++E 
Sbjct: 78  ERETWGKKVDFLLSVIGYAVDLGNIWRFPYVCYQNGGGAFLLPYIIMAIFGGIPLFYMEL 137

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y   + +G +          S+  +   IF  IG  +       + SYY  +I W+
Sbjct: 138 ALGQY---HRNGCI----------SIWRKICPIFKGIGYTICI-IAFYIASYYNTIIAWA 183

Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESYLSN-------- 157
             Y                SW        FS     + + ST+   E Y+ +        
Sbjct: 184 LYYLISSFTDRLPWTSCRNSWNTANCTNYFSEDNITWTLHSTSPAEEFYIRHILQIHRSK 243

Query: 158 --HGLVFLFWGITVVLLAI------AVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFA 208
               +  + W +T+ ++ I      ++ +GV + G   WV    P + V +V+LV     
Sbjct: 244 GLQDVGGVSWQLTLCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYI-VLSVLLVRGATL 302

Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYL 268
            G+      W   KG  F   PNW  L E    V + A+ QIFF+L  G G++  +ASY 
Sbjct: 303 PGA------W---KGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYN 351

Query: 269 GPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISEN 328
              ++     L T ++N     V G  I   L      +      +AK +  +L +I+  
Sbjct: 352 KFNNNCYQDALVTSAVNCMTSFVSGFVIFTVLGYMAEMRSEDVSEVAKDAGPSLLFIT-- 409

Query: 329 FGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISR 387
                +  ++P        A  FF  ++FL+L   G  S  A +   +TA+L+E   I  
Sbjct: 410 --YAEAIANMP--------ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWA 459

Query: 388 KTGTWIVF---IIYFLLGIPVVYING--YLDQVDAWISFQLALLALF-DIIVGVWLFKPD 441
           K   W V    I  F   +  +   G   +  ++ + +    L  +F + I   W +   
Sbjct: 460 KHREWFVLAVVITCFFGSLTTLTFGGAYVVKLLEEYATGPAVLTVVFIEAIAVSWFYGVT 519

Query: 442 NFWKELHEGALINVPEFYKWITVIIAPIFI 471
            F  ++ E    +   F++   V ++P+F+
Sbjct: 520 QFCSDVKEMLGFSPGWFWRICWVAVSPVFL 549


>sp|P23978|NTG1_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
           >gi|72010|pir||ACRTGT gamma-aminobutyric acid transport
           protein - rat >gi|204222|gb|AAA63487.1| (M59742) GABA
           transporter protein [Rattus norvegicus]
           Length = 599
           
 Score =  104 bits (256), Expect = 3e-21
 Identities = 133/572 (23%), Positives = 227/572 (39%), Gaps = 93/572 (16%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           +  RD W  +   +++  G AIGLGN  RFP     NGGGAF++PYFL L   G+P+  +
Sbjct: 41  LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100

Query: 68  EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           E   G+Y   G  G   L P F  +             GL    L+F     LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWKLAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143

Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
           I W+  Y + S +         N  +T + F +Y      +    V  FW          
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDG 203

Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
                       IT+ +  + V   + KG+  W   ++     +  I++I +F  G  L 
Sbjct: 204 LDKPGQIRWPLAITLAIAWVLVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 262

Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
             +    +G  F  +PN+  L +    V L A+ QIFF+  LG+G +    SY    ++V
Sbjct: 263 GAK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNV 316

Query: 275 ALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
               +    +N    +  G  I ++   +A+  K    +V A G              G 
Sbjct: 317 YRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GL 363

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKT 389
           ++ + P    Q+      +  L+F +L   G  S    +  ++TAL++E    L   R+ 
Sbjct: 364 AFLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRREL 422

Query: 390 GTWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFW 444
               V I+ +L+G+       +Y+    D   A     L  L  F+ +   W +  + F+
Sbjct: 423 FIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFY 481

Query: 445 KELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----A 494
             + E        ++K       PI +A     +   +   T+G      W   +    A
Sbjct: 482 DNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMA 541

Query: 495 IIAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
           + +M++I    AY  +  K G   ++ +V+I+
Sbjct: 542 LSSMVLIPGYMAYMFLTLK-GSLKQRLQVMIQ 572


>sp|P48057|NTG1_MUSCO SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
           >gi|533226|gb|AAA37663.1| (L32178) GABA transporter [Mus
           cookii]
           Length = 598
           
 Score =  103 bits (255), Expect = 4e-21
 Identities = 132/571 (23%), Positives = 227/571 (39%), Gaps = 92/571 (16%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           +  RD W  +   +++  G AIGLGN  RFP     NGGGAF++PYFL L   G+P+  +
Sbjct: 41  LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100

Query: 68  EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           E   G+Y   G  G   + P F  +             GL    L+F     LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWNVAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143

Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
           I W+  Y + S +         N  +T + F +Y      +    V  FW          
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDG 203

Query: 166 ----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQ 215
                      IT+ +  + V   + KG+  W   ++     +  I++I +F  G  L  
Sbjct: 204 LDKPGQIRCLAITLAIAWVLVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLPG 262

Query: 216 PQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVA 275
            +    +G  F  +PN+  L +    V L A+ QIFF+  LG+G +    SY    ++V 
Sbjct: 263 AK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVY 316

Query: 276 LSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFS 334
              +    +N    +  G  I ++   +A+  K    +V A G              G +
Sbjct: 317 RDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GLA 363

Query: 335 YTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKTG 390
           + + P    Q+      +  L+F +L   G  S    +  ++TAL++E    L   R+  
Sbjct: 364 FLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYSRLLRNRRELF 422

Query: 391 TWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFWK 445
              V I+ +L+G+       +Y+    D   A     L  L  F+ +   W +  + F+ 
Sbjct: 423 IAAVCIVSYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFYD 481

Query: 446 ELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----AI 495
            + E        ++K       PI +A     +   +   T+G      W   +    A+
Sbjct: 482 NIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMAL 541

Query: 496 IAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
            +M++I    AY  +  K G   ++ +V+I+
Sbjct: 542 SSMVLIPGYMAYMFLTLK-GSLKQRLQVMIQ 571


>pir||S65673 GABA transport protein - tobacco hornworm >gi|695378|gb|AAA92342.1|
           (L40373) GABA neurotransmitter transporter [Manduca
           sexta]
           Length = 597
           
 Score =  103 bits (254), Expect = 6e-21
 Identities = 123/498 (24%), Positives = 211/498 (41%), Gaps = 86/498 (17%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           + +R  WA+K+  IL++ G AIGLGN  RFP     NGGGAF++PYFL LFL GIP+ ++
Sbjct: 32  LPERGSWASKLDFILSVIGLAIGLGNVWRFPYLCYKNGGGAFLIPYFLTLFLAGIPMFFM 91

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           E   G+     G G                + A IF  IG A A   +  +N YY+ ++ 
Sbjct: 92  ELAMGQMLTIGGLGVF--------------KIAPIFKGIGYAAA-VMSCWMNVYYIVILA 136

Query: 128 WSAAYSWFSISG--------AYFNVESTAKFFE----SYLSNHGLVFLFW-----GITVV 170
           W+  Y + S+           Y+N  +    ++    +  S+ G +  F       ++  
Sbjct: 137 WAIFYFFMSMRSDVPWRNCDNYWNTATCVNPYDRKNLTCWSSLGDMSTFCTLNGRNVSKA 196

Query: 171 LLAIAVGQ-------GVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL---GQPQWST 220
           +L+  V +        +S GIE    +   L     ++ V+  F +   +   G+  + T
Sbjct: 197 VLSDPVKEFWERRALQISSGIEHIGNIRWELAGTLLLVWVLCYFCIWKGVRWTGKVVYFT 256

Query: 221 ---------------------IKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMG 259
                                ++G +F   PN + L E    V + A  QIFF+  LG+G
Sbjct: 257 ALFPYFLLTVLLIRGITLPGAMEGIKFYVMPNMSKLLES--EVWIDAVTQIFFSYGLGLG 314

Query: 260 IIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGS 318
            +    SY    ++V    L   S+N    +  G  I +V   +A+  +    EV A G 
Sbjct: 315 TLVALGSYNKFTNNVYKDALIVCSVNSSTSMFAGFVIFSVVGFMAHEQQRPVAEVAASGP 374

Query: 319 NAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTAL 378
                        G ++ + P+  +Q+  A  +    +F+LL     +    M  ++TA+
Sbjct: 375 -------------GLAFLAYPSAVLQLPGAPLWSCLFFFMLLLIGLDSQFCTMEGFITAV 421

Query: 379 LEEDLGISRKTG---TWIVFIIYFLLGIPVVYING-YLDQV-DAWI--SFQLALLALFDI 431
           ++E   + R+       I  II +L+G+  +   G Y+ Q+ D++    F L  L  F+ 
Sbjct: 422 IDEWPKLLRRRKEIFIAITCIISYLVGLSCISEGGMYVFQILDSYAVSGFCLLFLIFFEC 481

Query: 432 IVGVWLFKPDNFWKELHE 449
           +   W F  + F+  + E
Sbjct: 482 VSISWAFGVNRFYDGIKE 499


>pir||S68236 betaine/GABA transport protein BGT-1 - human
           >gi|881475|gb|AAA87029.1| (U27699) pephBGT-1
           betaine-GABA transporter [Homo sapiens]
           Length = 614
           
 Score =  102 bits (253), Expect = 8e-21
 Identities = 124/528 (23%), Positives = 222/528 (41%), Gaps = 89/528 (16%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           Q++ R +W  K+  +L++AG  IGLGN  RFP     NGGGAF +PYF+  F+ GIPV +
Sbjct: 32  QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFF 91

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
           +E   G+Y  +           + A   + P   L  G+  G  +    + LN YY+ ++
Sbjct: 92  LEVALGQYTSQGS---------VTAWRKICP---LFQGI--GLASVVIESYLNVYYIIIL 137

Query: 127 GWSAAYSWFSISGA--------YFNVESTAKF-----------FESYLSN---------- 157
            W+  Y + S +          ++N E    F           FE++ S           
Sbjct: 138 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVL 197

Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFA 208
                 H L  L W + + LL   +     + KG++   KV+     + + +++++ +  
Sbjct: 198 GITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRG 257

Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYL 268
           +  P         +G  +   P+   LK+    V + A  QIFF+ ++  G +    SY 
Sbjct: 258 VTLP------GAYQGIIYYLKPDLFRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYN 309

Query: 269 GPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISEN 328
              ++     +A   LN     V G  +   L      + VP   +A+            
Sbjct: 310 KYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAES----------- 358

Query: 329 FGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL-TALLEEDLGISR 387
            G G ++ + P   V M    + +  L+F++L F G  S       L TA ++      R
Sbjct: 359 -GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLR 416

Query: 388 KTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLAL--LALFDIIVGVWLF 438
           K+G        + ++ +L+G+ +V   G Y+ Q+ D + S  + L  L+LF+++   W++
Sbjct: 417 KSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVY 476

Query: 439 KPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPL-FGTFTDLVSK 485
             D F+  + +     +  +  W  V I+ +F+   L   TF   +SK
Sbjct: 477 GADRFYDNIED-----MIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519


>gi|4507037 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12; Solute carrier family 6
           (neurotransmitter transporter, betaine/GABA), [Homo
           sapiens] >gi|1352525|sp|P48065|NTBE_HUMAN SODIUM- AND
           CHLORIDE-DEPENDENT BETAINE TRANSPORTER
           (NA+/CL-BETAINE/GABA TRANSPORTER) (BGT-1)
           >gi|2119583|pir||I56522 betaine/GABA transporter - human
           >gi|808696|gb|AAA66574.1| (L42300) betaine/GABA
           transporter [Homo sapiens]
           Length = 614
           
 Score =  102 bits (253), Expect = 8e-21
 Identities = 124/528 (23%), Positives = 222/528 (41%), Gaps = 89/528 (16%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           Q++ R +W  K+  +L++AG  IGLGN  RFP     NGGGAF +PYF+  F+ GIPV +
Sbjct: 32  QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFF 91

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
           +E   G+Y  +           + A   + P   L  G+  G  +    + LN YY+ ++
Sbjct: 92  LEVALGQYTSQGS---------VTAWRKICP---LFQGI--GLASVVIESYLNVYYIIIL 137

Query: 127 GWSAAYSWFSISGA--------YFNVESTAKF-----------FESYLSN---------- 157
            W+  Y + S +          ++N E    F           FE++ S           
Sbjct: 138 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVL 197

Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFA 208
                 H L  L W + + LL   +     + KG++   KV+     + + +++++ +  
Sbjct: 198 GITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRG 257

Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYL 268
           +  P         +G  +   P+   LK+    V + A  QIFF+ ++  G +    SY 
Sbjct: 258 VTLP------GAYQGIIYYLKPDLFRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYN 309

Query: 269 GPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISEN 328
              ++     +A   LN     V G  +   L      + VP   +A+            
Sbjct: 310 KYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAES----------- 358

Query: 329 FGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL-TALLEEDLGISR 387
            G G ++ + P   V M    + +  L+F++L F G  S       L TA ++      R
Sbjct: 359 -GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLR 416

Query: 388 KTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLAL--LALFDIIVGVWLF 438
           K+G        + ++ +L+G+ +V   G Y+ Q+ D + S  + L  L+LF+++   W++
Sbjct: 417 KSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVY 476

Query: 439 KPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPL-FGTFTDLVSK 485
             D F+  + +     +  +  W  V I+ +F+   L   TF   +SK
Sbjct: 477 GADRFYDNIED-----MIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519


>gb|AAG01287.1|AF246893_1 (AF246893) serotonin transporter [Ovis aries]
           Length = 631
           
 Score =  101 bits (250), Expect = 2e-20
 Identities = 122/511 (23%), Positives = 212/511 (40%), Gaps = 88/511 (17%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ ++E 
Sbjct: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y   + +G +          S+  +   IF  IG A+       + SYY  ++ W+
Sbjct: 138 PLGQY---HRNGCI----------SIWTKICPIFKGIGCAICL-IAFYIASYYNTIMAWA 183

Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESYLSN-------- 157
             Y                SW        FS     + + ST+   E Y  +        
Sbjct: 184 LYYLISSFTEQLPWTSCENSWNTGNCTNYFSEDNITWMLHSTSPAEEFYTRHVLQIHRSK 243

Query: 158 --HGLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
               L  L W + + ++ I   +   + KG++   KV+  +  +F  I+++ +   G+ L
Sbjct: 244 GLQDLGGLSWQLVLCIMFIFTIIYFSIWKGVKTSGKVVW-VTAIFPYIILLILLVRGATL 302

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
               W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +ASY    ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNN 356

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
                L T ++N     V G  I   L      +      +AK +  +L +I+       
Sbjct: 357 CYQDALVTSAVNCMTSFVSGFVIFTVLGYMAEMRKEDVSEVAKDAGPSLLFIT----YAE 412

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEEDLGISRKTGTW 392
           +  ++P        A  FF  ++FL+L   G     A +   +TA+L+E   +  K   W
Sbjct: 413 AIANMP--------ASTFFAIVFFLMLITLGLDFTFAGLEGVITAVLDEFPHVWAKRREW 464

Query: 393 IVFIIYFLLGIPVVYINGYLDQVDAWISFQLALL------------ALFDIIVGVWLFKP 440
                 F+LG+ +    G L  +    ++ + LL            AL + +   W +  
Sbjct: 465 ------FVLGVVITCFFGSLVTLTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGI 518

Query: 441 DNFWKELHEGALINVPEFYKWITVIIAPIFI 471
           + F  ++ E    +   F+K   V I+P+F+
Sbjct: 519 NQFCIDVKEMLGFSPGWFWKICWVAISPLFL 549


>sp|P31646|NTG2_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 2
           >gi|348413|pir||A45078 gamma-aminobutyric acid
           transporter protein 2 - rat >gi|202523|gb|AAA40602.1|
           (M95762) GABA transporter [Rattus norvegicus]
           Length = 602
           
 Score =  101 bits (248), Expect = 3e-20
 Identities = 115/492 (23%), Positives = 207/492 (41%), Gaps = 92/492 (18%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R++W  K+  +L++AG  IGLGN  RFP     NGGGAF +PY + LF  GIPV ++E 
Sbjct: 31  EREQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLET 90

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y  + G         + A   + P    IF  IG A +    +LLN YY+ ++ W+
Sbjct: 91  ALGQYTNQGG---------ITAWRKICP----IFEGIGYA-SQMIVSLLNVYYIVVLAWA 136

Query: 130 AAYSWFSIS-----GAYFNVESTAKFFESYLSNHGL----------VFLFWGITVVLLAI 174
             Y + S +     G+  +  +T    E   +N+ L          V  FW   V    +
Sbjct: 137 LFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENATSPVIEFWERRV----L 192

Query: 175 AVGQGVSK-GIERWVKVMMPLL-------------------------YVFAVILVIYVFA 208
            +  G+   G  RW  V+  LL                         + + +++V+ +  
Sbjct: 193 KISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRG 252

Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLW--SVMLAASGQIFFTLSLGMGIIQNYAS 266
           +  P         +G +F   PN T     LW   V + A  QIFF+ ++ +G +    S
Sbjct: 253 VTLP------GAAQGIQFYLYPNIT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGS 302

Query: 267 YLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWIS 326
           Y    ++     +A   LN     V G +I   L      + VP   +A+          
Sbjct: 303 YNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVPISEVAES--------- 353

Query: 327 ENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGIS 386
              G G ++ + P   V +  +  +    +F+++     +  + + + +TAL++    + 
Sbjct: 354 ---GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVF 410

Query: 387 RKTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWL 437
           RK         IV ++ F +G+ ++   G Y+ Q+ D + +  + LL  A+F+ +   W+
Sbjct: 411 RKKNRREILILIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWV 470

Query: 438 FKPDNFWKELHE 449
           +    F+  + +
Sbjct: 471 YGASRFYDNIED 482


>sp|P48055|NTBE_RABIT SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
           (NA+/CL-BETAINE/GABA TRANSPORTER)
           >gi|847860|gb|AAA67953.1| (U26341) Na and Cl dependent
           betaine transporter [Oryctolagus cuniculus]
           >gi|1587626|prf||2207167A betaine transporter
           [Oryctolagus cuniculus]
           Length = 614
           
 Score =  101 bits (248), Expect = 3e-20
 Identities = 123/519 (23%), Positives = 222/519 (42%), Gaps = 65/519 (12%)

Query: 4   GVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIP 63
           G  Q + R +W  K+  +L++AG  IGL N  RFP     NGGGAF VPYF+  F  GIP
Sbjct: 29  GEDQAKDRGQWTNKMEFVLSVAGEIIGLSNVWRFPYLCYKNGGGAFFVPYFIFFFSCGIP 88

Query: 64  VMWVEWVQGRY---GGKYGHGTLGPTFYLMARESLKPRSAL-IFGLIGGALAFATTTLLN 119
           V ++E   G+Y   G       + P F  +   S+   S L ++ +I   LA+A   L +
Sbjct: 89  VFFLEVALGQYTSQGSVTAWKKICPLFQGIGLASVVIESYLNVYYII--ILAWALFYLFS 146

Query: 120 SYYLHL------IGWSAAYSWFSISGAYFNVESTAKFFESYLSN-------------HGL 160
           S+   L        W+  Y   +++ +   + S+ + F S +               H L
Sbjct: 147 SFTSELPWTTCTNSWNTEYCQHALNHSGAGIGSSTENFTSPVMEFWERRVLGITAGIHDL 206

Query: 161 VFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQ 217
             L W + + LL   I     + KG++   KV+     + + +++++ +  +  P     
Sbjct: 207 GALRWELALCLLLAWIVCYFCIWKGVKYTGKVVYFTATFPYLMLVILLIRGVTLP----- 261

Query: 218 WSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALS 277
               +G  +   P+   LK+    V + A  QIFF+ ++  G +    SY    ++    
Sbjct: 262 -GAYQGIVYYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRD 318

Query: 278 GLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTS 337
            +A   LN     V G  +   L      + VP   +A+             G G ++ +
Sbjct: 319 SIALCFLNSATSFVAGFVVFSVLGFMSQEQGVPISEVAES------------GPGLAFIA 366

Query: 338 LPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEEDLGISRKTG-----T 391
            P   V M    + +  L+F++L F G  S  + M   +TA ++      RK+G      
Sbjct: 367 FPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCMECLVTASVDMFPRQLRKSGRRELLI 425

Query: 392 WIVFIIYFLLGIPVVYING-YLDQVDAWISFQ---LALLALFDIIVGVWLFKPDNFWKEL 447
             + ++ +L+G+ +V   G Y+ Q+  + +     L  L++F+++   W++  D F+  +
Sbjct: 426 LAIAVLCYLIGLLLVTEGGMYIFQLFDYYACSGICLLFLSVFEVVSISWVYGADRFYDNI 485

Query: 448 HEGALINVPEFYKWITVIIAPIFIALPL-FGTFTDLVSK 485
            +     +  +  W  V I+ +F+   L   TF   +SK
Sbjct: 486 QD-----MIGYRPWPLVKISWLFLTPGLCLATFLFSLSK 519


>sp|P31648|NTG1_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1
           >gi|423439|pir||F46027 gamma-aminobutyric acid
           transporter - mouse
           Length = 598
           
 Score =  100 bits (247), Expect = 4e-20
 Identities = 131/572 (22%), Positives = 226/572 (38%), Gaps = 94/572 (16%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           +  RD W  +   +++  G AIGLGN  RFP     NGGGAF++PYFL L   G+P+  +
Sbjct: 41  LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100

Query: 68  EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL-LNSYYLH 124
           E   G+Y   G  G     P F                   G A+A A  +  LN YY+ 
Sbjct: 101 ECSLGQYTSIGGLGVWNWAPMFK------------------GVAVAAAVLSFWLNIYYIV 142

Query: 125 LIGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW--------- 165
           +I W+  Y + S +         N  +T + F +Y      +    V  FW         
Sbjct: 143 IISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTD 202

Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
                       IT+ +  + V   + KG+  W   ++     +  I++I +F  G  L 
Sbjct: 203 GLDKPGQIRCLAITLAIAWVLVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 261

Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
             +    +G  F  +PN+  L +    V+  A+ QIFF+  LG+G +    SY    ++V
Sbjct: 262 GAK----EGILFYITPNFRKLSDS--EVIFDAATQIFFSYGLGLGSLIALGSYNSFHNNV 315

Query: 275 ALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
               +    +N    +  G  I ++   +A+  K    +V A G              G 
Sbjct: 316 YRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGP-------------GL 362

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRKT 389
           ++ + P    Q+      +  L+F +L   G  S    +  ++TAL++E    L   R+ 
Sbjct: 363 AFLAYPEAVTQL-PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRREL 421

Query: 390 GTWIVFIIYFLLGIP-----VVYINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNFW 444
               V I+ +L+G+       +Y+    D   A     L  L  F+ +   W +  + F+
Sbjct: 422 FIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSA-SGMSLLFLVFFECVSISWFYGVNRFY 480

Query: 445 KELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLG------WPAKI----A 494
             + E        ++K       PI +A     +   +   T+G      W   +    A
Sbjct: 481 DNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMA 540

Query: 495 IIAMLIIGAIEAYYAIKKKYGEELEKNEVIIK 526
           + +M++I    AY  +  K G   ++ +V+I+
Sbjct: 541 LSSMVLIPGYMAYMFLTLK-GSLKQRLQVMIQ 571


>pir||I51368 gamma-aminobutyric acid transport protein GAT-1 - Pacific electric
           ray >gi|444010|emb|CAA54394.1| (X77139) GAT-1 GABA
           transporter [Torpedo californica]
           Length = 598
           
 Score = 99.5 bits (244), Expect = 9e-20
 Identities = 113/486 (23%), Positives = 199/486 (40%), Gaps = 82/486 (16%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           ++ +R+KW  +   +L+  G AIGLGN  RFP     NGGGAF++PYF+ L   G+P+  
Sbjct: 39  KIPEREKWGGRYDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFMTLIFAGMPIFL 98

Query: 67  VEWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLH 124
           +E   G+Y   G  G   L P F  +             GL    L+F     LN YY+ 
Sbjct: 99  LECSLGQYTSVGGLGIWRLAPMFKGV-------------GLAAAVLSF----WLNIYYVV 141

Query: 125 LIGWSAAYSWFSISG-----AYFNVESTAKFFESYLSNHGL-----VFLFW--------- 165
           +I W+  Y + S +      +  N  +T + F +Y   +       +  FW         
Sbjct: 142 IIAWAIYYLYNSFTSELPWQSCGNSWNTDRCFSNYSMTNSTNLSSPIVEFWERNMHQLTD 201

Query: 166 ------------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
                        IT+ +  + V   + KG+  W   ++    ++  I+++ +F  G  L
Sbjct: 202 GLDQPGQIRAPLAITLAIAWVLVYFCIWKGVS-WTGKVVYFSAIYPYIMLLTLFFRGVTL 260

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
              +    +G  F  +P++  L +    V L A+ QIFF+  LG+G +    SY    ++
Sbjct: 261 PGAR----EGILFYITPDFRRLSDS--EVWLDAATQIFFSYGLGLGSLVALGSYNKFHNN 314

Query: 274 VALSGLATVSLNEFAEVVLGGSI-AVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLG 332
           V    +    +N    +  G  I ++   +A+       +V A G              G
Sbjct: 315 VYRDSIIVCCINSTTSMFAGFVIFSIVGFMAHVTNRPIADVAASGP-------------G 361

Query: 333 FSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEED---LGISRK 388
            ++ + P    Q+      +  L+F +L   G  S    +  ++TAL++E    L   R+
Sbjct: 362 LAFLAYPEAVTQL-PISPLWSILFFSMLLMLGIDSQFCTVEGFITALVDEFPKLLRGRRE 420

Query: 389 TGTWIVFIIYFLLGIPVV-----YINGYLDQVDAWISFQLALLALFDIIVGVWLFKPDNF 443
               +V I+ +L+G+  +     Y+    D   A     L  L  F+ +   W +  + F
Sbjct: 421 IFIAMVCIVSYLIGLSNITQGGLYVFKLFDYYSA-SGMSLLFLVFFETVSISWCYGVNRF 479

Query: 444 WKELHE 449
           +  + E
Sbjct: 480 FVNIEE 485


>gb|AAG20907.1| (AE005157) sodium-dependent transporter; YocR [Halobacterium sp.
           NRC-1]
           Length = 419
           
 Score = 99.5 bits (244), Expect = 9e-20
 Identities = 100/352 (28%), Positives = 159/352 (44%), Gaps = 47/352 (13%)

Query: 53  YFLALFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAF 112
           Y L +  +G+P +  E+V GR G +   G L        R  +  R    +G   G    
Sbjct: 2   YLLLVVGIGVPGLLAEFVLGRRGRQTPIGAL--------RSLIGSR----WGTAVGTFNV 49

Query: 113 ATTTLLNSYYLHLIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFL-FWGITVVL 171
            TT ++ S+Y  + GW   Y+  S +GAYF      ++F    ++HGL  + F  + + +
Sbjct: 50  ITTVVMLSFYSVVGGWILRYTLLSPTGAYF--AQPQQYFSH--ASHGLPAVGFHLLFLGI 105

Query: 172 LAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPN 231
           +A+ V  GVS+GIER  KVM+P + V    L ++           Q +T  G+ F    +
Sbjct: 106 IALIVFFGVSQGIERVSKVMLPAVVVLLGGLAVWTAT--------QPNTAAGYAFYLGFD 157

Query: 232 WTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL-SGLATVSLNEFAEV 290
             YL  + +SV+  A+GQ  FTLSLG G +  YASYL   DD +L      ++++  A  
Sbjct: 158 PDYLAANFFSVLGPAAGQALFTLSLGAGAMLTYASYL--DDDASLPRDTVVIAISNTAIG 215

Query: 291 VLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGR 350
           VL G + +PL ++    I P     +G   AL        L  ++ +LP         G 
Sbjct: 216 VLAGLVVLPLLISQG--ITP----GQGGPGAL-----FVALATAFGALP--------GGN 256

Query: 351 FFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLG 402
               ++F  +  A  TS I +     A L ++   SR+  T  V ++    G
Sbjct: 257 VVATVFFFTVLLAAVTSGINLLETPVATLVDNYNASRRVATAAVTLLLAATG 308


>gi|4507043 solute carrier family 6 (neurotransmitter transporter, serotonin),
           member 4; Solute carrier family 6 (neurotransmitter
           transporter, serotonin), [Homo sapiens]
           >gi|400630|sp|P31645|NTSE_HUMAN SODIUM-DEPENDENT
           SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
           >gi|476966|pir||A47398 serotonin transporter - human
           >gi|36433|emb|CAA50029.1| (X70697) serotonin transporter
           [Homo sapiens] >gi|291820|gb|AAA35492.1| (L05568)
           Na+/Cl- dependent serotonin transporter [Homo sapiens]
           >gi|300444|gb|AAB26687.1| serotonin transporter,
           serotonin uptake site, 5-HT uptake site [human,
           platelets, Peptide, 630 aa]
           Length = 630
           
 Score = 98.7 bits (242), Expect = 1e-19
 Identities = 117/505 (23%), Positives = 210/505 (41%), Gaps = 76/505 (15%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ ++E 
Sbjct: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y   + +G +          S+  +   IF  IG A+       + SYY  ++ W+
Sbjct: 138 ALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTIMAWA 183

Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESY----------- 154
             Y                SW        FS     + + ST+   E Y           
Sbjct: 184 LYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 243

Query: 155 -LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
            L + G +     + ++L+   +   + KG++   KV+  +   F  I++  +   G+ L
Sbjct: 244 GLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILSVLLVRGATL 302

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
               W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +ASY    ++
Sbjct: 303 -PGAW---RGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNN 356

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
                L T  +N     V G  I   L             +A+  N  +  ++++ G   
Sbjct: 357 CYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSEVAKDAGPSL 405

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE--DLGISRKTG 390
            + +       M  A  FF  ++FL+L   G  S  A +   +TA+L+E   +   R+  
Sbjct: 406 LFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRER 464

Query: 391 TWIVFIIYFLLG--IPVVYINGYLDQVDAWISFQLALL--ALFDIIVGVWLFKPDNFWKE 446
             +  +I    G  + + +   Y+ ++    +   A+L  AL + +   W +    F ++
Sbjct: 465 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRD 524

Query: 447 LHEGALINVPEFYKWITVIIAPIFI 471
           + E    +   F++   V I+P+F+
Sbjct: 525 VKEMLGFSPGWFWRICWVAISPLFL 549


>gi|7657587 solute carrier family 6 (neurotransmitter transporter, GABA),
           member 11 [Homo sapiens]
           >gi|1352531|sp|P48066|NTG3_HUMAN SODIUM- AND
           CHLORIDE-DEPENDENT GABA TRANSPORTER 3
           >gi|913242|gb|AAB33570.1| (S75989) gamma-aminobutyric
           acid transporter type 3, GABA transporter type 3, GAT-3
           [human, fetal brain, Peptide, 632 aa] [Homo sapiens]
           Length = 632
           
 Score = 98.7 bits (242), Expect = 1e-19
 Identities = 121/516 (23%), Positives = 215/516 (41%), Gaps = 96/516 (18%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           + +R  W  K+  +L++AG  IGLGN  RFP     NGGGAF++PY +     GIPV ++
Sbjct: 47  VHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFL 106

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYLH 124
           E   G++  + G         +     + P    +F  IG    +AT  +   LN YY+ 
Sbjct: 107 ETALGQFTSEGG---------ITCWRKVCP----LFEGIG----YATQVIEAHLNVYYII 149

Query: 125 LIGWSAAY---------SWFSISGAYFNVESTAKFFESYLSNHGLVFL---------FWG 166
           ++ W+  Y          W +  G  +N E+  +F +  +SN+  V L         FW 
Sbjct: 150 ILAWAIFYLSNCFTTELPW-ATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWE 208

Query: 167 ITVVLLAIAVGQGVSK-GIERW--------------------VKVMMPLLYV---FAVIL 202
             V    +A+  G+   G  RW                     K    ++YV   F  I+
Sbjct: 209 HRV----LAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIM 264

Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
           ++ +   G  L        +G +F   P+ + L +    V + A  QIFF+ ++ +G + 
Sbjct: 265 LLILLIRGVTLP----GASEGIKFYLYPDLSRLSDP--QVWVDAGTQIFFSYAICLGCLT 318

Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
              SY    ++     +    LN     V G +I   L      + VP   +A+      
Sbjct: 319 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAES----- 373

Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEE 381
                  G G ++ + P   V M      +  L+F++L F G  S  + + + +TA+++ 
Sbjct: 374 -------GPGLAFIAYPKA-VTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM 425

Query: 382 -----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDII 432
                  G  R+     + +I + LG+ ++   G Y+ Q+ D++ +  + LL  A+F+ I
Sbjct: 426 YPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECI 485

Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP 468
              W++  + F+  + +      P   KW  +I+ P
Sbjct: 486 CIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTP 521


>gi|11428196 solute carrier family 6 (neurotransmitter transporter, serotonin),
           member 4 [Homo sapiens]
           Length = 654
           
 Score = 98.7 bits (242), Expect = 1e-19
 Identities = 117/505 (23%), Positives = 210/505 (41%), Gaps = 76/505 (15%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ W  K+  +L++ G A+ LGN  RFP     NGGGAF++PY +     GIP+ ++E 
Sbjct: 102 ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 161

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y   + +G +          S+  +   IF  IG A+       + SYY  ++ W+
Sbjct: 162 ALGQY---HRNGCI----------SIWRKICPIFKGIGYAICI-IAFYIASYYNTIMAWA 207

Query: 130 AAY----------------SW--------FSISGAYFNVESTAKFFESY----------- 154
             Y                SW        FS     + + ST+   E Y           
Sbjct: 208 LYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSK 267

Query: 155 -LSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
            L + G +     + ++L+   +   + KG++   KV+  +   F  I++  +   G+ L
Sbjct: 268 GLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVW-VTATFPYIILSVLLVRGATL 326

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
               W   +G  F   PNW  L E    V + A+ QIFF+L  G G++  +ASY    ++
Sbjct: 327 -PGAW---RGVLFYLKPNWQKLLE--TGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNN 380

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
                L T  +N     V G  I   L             +A+  N  +  ++++ G   
Sbjct: 381 CYQDALVTSVVNCMTSFVSGFVIFTVLG-----------YMAEMRNEDVSEVAKDAGPSL 429

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE--DLGISRKTG 390
            + +       M  A  FF  ++FL+L   G  S  A +   +TA+L+E   +   R+  
Sbjct: 430 LFITYAEAIANM-PASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRER 488

Query: 391 TWIVFIIYFLLG--IPVVYINGYLDQVDAWISFQLALL--ALFDIIVGVWLFKPDNFWKE 446
             +  +I    G  + + +   Y+ ++    +   A+L  AL + +   W +    F ++
Sbjct: 489 FVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRD 548

Query: 447 LHEGALINVPEFYKWITVIIAPIFI 471
           + E    +   F++   V I+P+F+
Sbjct: 549 VKEMLGFSPGWFWRICWVAISPLFL 573


>sp|P27799|NTBE_CANFA SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER
           (NA+/CL-BETAINE/GABA TRANSPORTER) >gi|89018|pir||A41757
           betaine transport protein, renal - dog
           >gi|455158|gb|AAA30877.1| (M80403) Na+- and Cl-
           dependent betaine transporter [Canis familiaris]
           >gi|2463606|dbj|BAA22547.1| (D42037) Betain-GABA
           transporter [Canis familiaris]
           Length = 614
           
 Score = 97.5 bits (239), Expect = 3e-19
 Identities = 115/494 (23%), Positives = 204/494 (41%), Gaps = 83/494 (16%)

Query: 4   GVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIP 63
           G  Q++ R +W  K+  +L++AG  IGLGN  RFP     NGGGAF +PYF+  F  GIP
Sbjct: 29  GEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFTCGIP 88

Query: 64  VMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYL 123
           V ++E   G+Y  +           + A   + P   L+ G+  G  +    + LN YY+
Sbjct: 89  VFFLEVALGQYTSQGS---------VTAWRKICP---LLQGI--GLASVVIESYLNIYYI 134

Query: 124 HLIGWSAAYSWFSISGAY--------FNVE-----------STAKFFESYLSN------- 157
            ++ W+  Y + S +           +N E            TA   E++ S        
Sbjct: 135 IILAWALFYLFSSFTSELPWTTCTNTWNTEHCMDFLNHSGARTATSSENFTSPVMEFWER 194

Query: 158 ---------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIY 205
                    H L  L W + + LL   +     + KG++   KV+     + + +++++ 
Sbjct: 195 RVLGITSGIHDLGALRWELALCLLLAWLICYFCIWKGVKTTGKVVYFTATFPYLMLVILL 254

Query: 206 VFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYA 265
           +  +  P         +G  +   P+   LK+    V + A  QIFF+ ++  G +    
Sbjct: 255 IRGITLP------GAYQGVIYYLKPDLLRLKDP--QVWMDAGTQIFFSFAICQGCLTALG 306

Query: 266 SYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWI 325
           SY    ++     +A   LN       G  +   L      + +P   +A+         
Sbjct: 307 SYNKYHNNCYRDSIALCFLNSATSFAAGFVVFSILGFMAQEQGLPISEVAES-------- 358

Query: 326 SENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYL-TALLEEDLG 384
               G G ++ + P   V M    + +  L+F++L F G  S       L TA ++    
Sbjct: 359 ----GPGLAFIAFPKA-VTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASMDMFPS 413

Query: 385 ISRKTG-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLAL--LALFDIIVGV 435
             RK+G        + +  +L G+ +V   G Y+ Q+ D + S  + L  LA+F++I   
Sbjct: 414 QLRKSGRRELLILAIAVFCYLAGLFLVTEGGMYIFQLFDYYASSGICLLFLAMFEVICIS 473

Query: 436 WLFKPDNFWKELHE 449
           W++  D F+  + +
Sbjct: 474 WVYGADRFYDNIED 487


>gb|AAF21642.1|AF032873_1 (AF032873) inebriated protein [Manduca sexta]
           Length = 727
           
 Score = 97.5 bits (239), Expect = 3e-19
 Identities = 131/568 (23%), Positives = 224/568 (39%), Gaps = 103/568 (18%)

Query: 2   DRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLG 61
           D  V    +R  WA KI  +LA  G ++GLGN  RFP     +GGGAF++PYF+ L + G
Sbjct: 156 DAAVHLKPRRPFWANKIQFVLACVGYSVGLGNVWRFPYLCYKSGGGAFLIPYFIILLICG 215

Query: 62  IPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSY 121
           +P++++E   G+Y     HG +G         +L     L  G   G  +   + L+++Y
Sbjct: 216 VPMLFMELAIGQY---TAHGPIG---------ALSQICPLFKG--AGLASVVISFLMSTY 261

Query: 122 YLHLIGWSAAY---------SWFSISGAYFNVE----------------STAKFFESYLS 156
           Y  +I W+  Y          W S S  +   +                 T +FFE  + 
Sbjct: 262 YAVIIAWAIYYFFTSFKTEVPWASCSNRWNTDQCWVPNHNHTKPNGSQTPTEQFFERKVL 321

Query: 157 NHGLVFLF-WGITVVLLAIAVGQGVSKGIERW--VKVMMPLLYVFAVI--LVIYVFALGS 211
           N      +  G+   L A  V   V      W  +K    + Y+   +  L+I VF LG 
Sbjct: 322 NMSAGIEYPGGMRWELAACLVCAWVLVYFALWKSIKSSAKVRYITTTLPFLLIIVF-LGR 380

Query: 212 PLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPK 271
            L         G  F + P+W  LK+      + A+ QIF ++ +  G +  +ASY    
Sbjct: 381 SLTLD--GADGGLRFFFKPDWELLKQS--RPWVNAASQIFNSIGIAFGSMIMFASY---- 432

Query: 272 DDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQW------- 324
                        N F    L  ++AV L  A    IV     A   N A +        
Sbjct: 433 -------------NRFDNNFLHDTVAVTLVNAITSLIVGIFTFATIGNIAFEQNTPVKDV 479

Query: 325 ISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL- 383
           I+++ GL F     P    +M  A + +  L+F +    G  S  A+   +   +++   
Sbjct: 480 IADSPGLLF--VVYPQAIAKM-PASQLWAVLFFFMFLCLGLNSQFAIVEVVVTSIQDGFP 536

Query: 384 GISRKTGTW------IVFIIYFLLGIPVVYING-YLDQVDAWISFQLAL--LALFDIIVG 434
            + RK   +      +V  +  L G+P +  +G Y+ Q+  + +  L++  LA F+++  
Sbjct: 537 DMIRKRLVYHELLVLLVCAVSLLCGLPHIIHSGIYVFQLMDYYAASLSITYLAFFEVVAI 596

Query: 435 VWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLV----------- 483
            W +      + + +        ++++  +I +P  +      +  D             
Sbjct: 597 AWFYGVGRLSRNIKQMTGRQPSLYFRFCWLIASPALLLALWVASMVDYTPPSYRQYQYPA 656

Query: 484 -SKTLGWPAKIAIIAMLIIGAIEAYYAI 510
            ++ LGW     I+A L +  I  Y  I
Sbjct: 657 WAQALGW-----IMASLSLLCIPVYAVI 679


>sp|P31649|NTG3_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3 (GAT3)
           >gi|346709|pir||A44409 gamma-aminobutyric acid transport
           protein 3 - mouse
           Length = 602
           
 Score = 97.1 bits (238), Expect = 4e-19
 Identities = 115/489 (23%), Positives = 202/489 (40%), Gaps = 86/489 (17%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           +R+ W  K+  +L++AG  IGLGN  RFP     NGGGAF +PY + LF  GIPV ++E 
Sbjct: 31  EREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLET 90

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y  + G         + A   + P    IF  IG A     + LLN YY+ ++ W+
Sbjct: 91  ALGQYTNQGG---------ITAWRRICP----IFEGIGYASQMIVS-LLNVYYIVVLAWA 136

Query: 130 AAYSWFSIS-----GAYFNVESTAKFFESYLSNHGL----------VFLFWGITVVLLAI 174
             Y + S +     G+  +  +T    E   +N  +          V  FW   V+ L+ 
Sbjct: 137 LFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSD 196

Query: 175 AVGQGVSKGIERWVKVMMPLLY-----------------------VFAVILVIYVFALGS 211
            +      G  RW  V+  LL                         F  ++++ +   G 
Sbjct: 197 GIQH---LGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGV 253

Query: 212 PLGQPQWSTIKGFEFIWSPNWTYLKEHLWS--VMLAASGQIFFTLSLGMGIIQNYASYLG 269
            L        +G +F   PN T     LW   V + A  QIFF+ ++ +G +    SY  
Sbjct: 254 TLP----GAAQGIQFYLYPNIT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNK 305

Query: 270 PKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF 329
             ++     +A   LN     + G +I   L      + VP   +A+             
Sbjct: 306 YHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAES------------ 353

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKT 389
           G G ++ + P   V +  +  +    +F+++     +  + + + +TAL++    + RK 
Sbjct: 354 GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKK 413

Query: 390 G-----TWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFKP 440
                   IV +I F +G+ ++   G Y+ Q+ D + +  + LL  A+F+ +   W++  
Sbjct: 414 NRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGA 473

Query: 441 DNFWKELHE 449
             F+  + +
Sbjct: 474 GRFYDNIED 482


>pir||I56506 Na+/Cl(-)-dependent neurotransmitter transporter, brain - rat
           >gi|545078|gb|AAC60673.1| (S68944) Na+/Cl(-)-dependent
           neurotransmitter transporter [rats, brain, Peptide, 727
           aa] [Rattus sp.]
           Length = 727
           
 Score = 96.3 bits (236), Expect = 8e-19
 Identities = 131/573 (22%), Positives = 225/573 (38%), Gaps = 110/573 (19%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           +  E R  W +K+  ILA  G ++GLGN  RFP     NGGGA++VPY + L ++GIP+ 
Sbjct: 55  LDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLF 114

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           ++E   G+   +   G++G   Y+  R      S+ I  L  G            YY  +
Sbjct: 115 FLELAVGQ---RIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGL-----------YYNVI 160

Query: 126 IGWSAAYSWFSI-------------SGAYFNVE------STAKFF--------ESYLSNH 158
           IGWS  Y + S              +G    VE      S   +F         + +S  
Sbjct: 161 IGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISES 220

Query: 159 GLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQP 216
           G   L W +TV LL     VG  V KGI+   KVM      F+ +    V A     G  
Sbjct: 221 G--GLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVM-----YFSSLFPCVVLACFLVRGLL 273

Query: 217 QWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL 276
               + G   +++P    + +    V   A+ Q+FF L LG G +  ++SY   +D+   
Sbjct: 274 LRGAVDGILHMFTPKLDKMLDP--QVWREAATQVFFALGLGFGGVIAFSSY-NKQDNNCH 330

Query: 277 SGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF------- 329
              A VS   F   VL  ++ V   + +   I+  + + + +   L +++ N        
Sbjct: 331 FDAALVSFINFFTSVL-ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIP 389

Query: 330 -GLGFS------YTSLPNIFVQM------------------------GT----------- 347
             + FS      Y+ + N+ + +                        GT           
Sbjct: 390 PHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAM 449

Query: 348 ----AGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGI 403
               A  F+  ++FL+L   G  S I     +T  + +   + ++  T    +  F +G+
Sbjct: 450 THFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVSCCVFAFFVGL 509

Query: 404 PVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYK 460
             V  +G  ++   D +  +  L ++ + + I   W++    F +EL E        FY 
Sbjct: 510 LFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYF 569

Query: 461 WITVIIAPIFIALPLFGTFTDLVSKTLGWPAKI 493
           ++   ++P+ +A+    +   L     G+ A I
Sbjct: 570 YMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWI 602


>sp|P31662|NTT4_RAT SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER NTT4
           >gi|285126|pir||S27043 neurotransmitter transport
           protein - rat >gi|262843|gb|AAB24776.1| (L06434)
           neurotransmitter transporter [Rattus sp.]
           Length = 727
           
 Score = 95.6 bits (234), Expect = 1e-18
 Identities = 131/573 (22%), Positives = 225/573 (38%), Gaps = 110/573 (19%)

Query: 6   IQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVM 65
           +  E R  W +K+  ILA  G ++GLGN  RFP     NGGGA++VPY + L ++GIP+ 
Sbjct: 55  LDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLF 114

Query: 66  WVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           ++E   G+   +   G++G   Y+  R      S+ I  L  G            YY  +
Sbjct: 115 FLELAVGQ---RIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGL-----------YYNVI 160

Query: 126 IGWSAAYSWFSI-------------SGAYFNVE------STAKFF--------ESYLSNH 158
           IGWS  Y + S              +G    VE      S   +F         + +S  
Sbjct: 161 IGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISES 220

Query: 159 GLVFLFWGITVVLLAI--AVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQP 216
           G   L W +TV LL     VG  V KGI+   KVM      F+ +    V A     G  
Sbjct: 221 G--GLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVM-----YFSSLFPYVVLACFLVRGLL 273

Query: 217 QWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVAL 276
               + G   +++P    + +    V   A+ Q+FF L LG G +  ++SY   +D+   
Sbjct: 274 LRGAVDGILHMFTPKLDKMLDP--QVWREAATQVFFALGLGFGGVIAFSSY-NKQDNNCH 330

Query: 277 SGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENF------- 329
              A VS   F   VL  ++ V   + +   I+  + + + +   L +++ N        
Sbjct: 331 FDAALVSFINFFTSVL-ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIP 389

Query: 330 -GLGFS------YTSLPNIFVQM------------------------GT----------- 347
             + FS      Y+ + N+ + +                        GT           
Sbjct: 390 PHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAM 449

Query: 348 ----AGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGI 403
               A  F+  ++FL+L   G  S I     +T  + +   + ++  T    +  F +G+
Sbjct: 450 THFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVGL 509

Query: 404 PVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNFWKELHEGALINVPEFYK 460
             V  +G  ++   D +  +  L ++ + + I   W++    F +EL E        FY 
Sbjct: 510 LFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYF 569

Query: 461 WITVIIAPIFIALPLFGTFTDLVSKTLGWPAKI 493
           ++   ++P+ +A+    +   L     G+ A I
Sbjct: 570 YMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWI 602


>pir||C71376 probable sodium- and chloride- dependent transporter - syphilis
           spirochete >gi|3322276|gb|AAC65017.1| (AE001187) sodium-
           and chloride- dependent transporter [Treponema pallidum]
           Length = 443
           
 Score = 94.8 bits (232), Expect = 2e-18
 Identities = 102/430 (23%), Positives = 179/430 (40%), Gaps = 54/430 (12%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R+ + + +G++L+  G A+GL N   FP ++   GG  F++PYF+ LF L          
Sbjct: 8   RELFNSHVGVVLSCVGAAMGLANVWLFPGRLVEFGGVTFLIPYFIFLFGL---------- 57

Query: 71  QGRYG--GKYGHG---TLGPTFYLMARESLKPRSALIFGLIG-GALAFATTTLLNSYYLH 124
             R+G  G+Y  G     GP      R      S  +  L G G           S+Y+ 
Sbjct: 58  -SRFGLMGEYAFGKTLRCGPV-RAFTRVCETHPSCFLRALRGSGWFPVGVLLATCSFYVV 115

Query: 125 LIGWSAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGI 184
           +IGW   Y  FS + A    ++   F++   ++  + +      + L A  V  GV KG+
Sbjct: 116 IIGWILRYVVFSCTNALAGTQAHDLFYQVAGTSANVPWTL--AAIALTACVVSAGVQKGV 173

Query: 185 ERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVML 244
           ER   +MM L Y     +  Y+F L +      W  ++    +   + +     LW   L
Sbjct: 174 ERGNIIMMVLFYGVLAFITGYIFTLPN-----AWIGMR--RMLAFQSSSLCNPRLW---L 223

Query: 245 AASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAY 304
            A G  FF+LSLG   +  Y SY+    D+  +   T +L+  A     G  A+ L    
Sbjct: 224 YALGMSFFSLSLGGAAMVLYGSYMPDTVDIPRTAFQTATLDFLA----SGMSALCL---- 275

Query: 305 APKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAG 364
               +P        +A +  +  + G  F + ++  +  Q+   G     L+FL +  A 
Sbjct: 276 ----IP--------SAWVLGMDVSSGPEFLFVTITRVASQI-PMGVMISVLFFLCVLCAA 322

Query: 365 FTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLA 424
            +SAIAM   +         + R+T TW + ++   + +P   +N  +   + +    + 
Sbjct: 323 LSSAIAMLEVILESFVHTCTVGRRTLTWSLALVVAFVSLP---LNASMRVFETFTDIVVV 379

Query: 425 LLALFDIIVG 434
           +L+    ++G
Sbjct: 380 ILSPLSALMG 389


>gb|AAD10615.1| (U02296) cocaine-sensitive serotonin transporter [Drosophila
           melanogaster] >gi|740251|prf||2004470A cocaine-sensitive
           serotonin transporter [Drosophila melanogaster]
           Length = 581
           
 Score = 94.0 bits (230), Expect = 4e-18
 Identities = 127/510 (24%), Positives = 205/510 (39%), Gaps = 92/510 (18%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R+ W  K   +LA+ G A+ LGN  RFP     NGGGAF+VPY L L   G+P+ ++E  
Sbjct: 33  RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELA 92

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            G+             F+     S+  R       +G A+       +  YY  +IGW+ 
Sbjct: 93  LGQ-------------FHRCGCLSIWKRICPALKGVGYAICL-IDIYMGMYYNTIIGWAV 138

Query: 131 AYSWFSISGAY--------FNVE---------------STAKFF------ESYLSNHGLV 161
            Y + S +           +N E               S AK F      ESY  N GL 
Sbjct: 139 YYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERKVLESYKGN-GLD 197

Query: 162 FL----------FWGITVVLLAIAVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALG 210
           F+           +G+  VL+  ++ +GV S G   WV  + P    + V++++ V  + 
Sbjct: 198 FMGPVKPTLALCVFGV-FVLVYFSLWKGVRSAGKVVWVTALAP----YVVLIILLVRGVS 252

Query: 211 SPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGP 270
            P         +G ++  +P W  LK     V + A+ QIFF+L  G G +   +SY   
Sbjct: 253 LP------GADEGIKYYLTPEWHKLKNS--KVWIDAASQIFFSLGPGFGTLLALSSYNKF 304

Query: 271 KDDVALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENF 329
            ++     L T S+N     + G  I   L  +AY  K    +V  +G            
Sbjct: 305 NNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGP----------- 353

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEE---DLGI 385
             G  +   P     M +   F+  ++FL+L   G  S    +   +TAL +E    +G 
Sbjct: 354 --GLVFIVYPEAIATM-SGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGR 410

Query: 386 SRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALFDIIV---GV-WLFKPD 441
            R+    ++    FL  +P +   G +  V+    +   L  LF + V   GV W +  D
Sbjct: 411 RRELFVLLLLAFIFLCALPTMTYGGVV-LVNFLNVYGPGLAILFVVFVEAAGVFWFYGVD 469

Query: 442 NFWKELHEGALINVPEFYKWITVIIAPIFI 471
            F  ++ +        F++     I+P+F+
Sbjct: 470 RFSSDVEQMLGSKPGLFWRICWTYISPVFL 499


>sp|P51905|NTSE_DROME SODIUM-DEPENDENT SEROTONIN TRANSPORTER (5HT TRANSPORTER) (5HTT)
           (COCAINE-SENSITIVE SEROTONIN TRANSPORTER)
           >gi|506640|gb|AAA19430.1| (U04809) cocaine-sensitive
           serotonin transporter [Drosophila melanogaster]
           >gi|7291780|gb|AAF47200.1| (AE003464) SerT gene product
           [Drosophila melanogaster]
           Length = 622
           
 Score = 94.0 bits (230), Expect = 4e-18
 Identities = 127/510 (24%), Positives = 205/510 (39%), Gaps = 92/510 (18%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R+ W  K   +LA+ G A+ LGN  RFP     NGGGAF+VPY L L   G+P+ ++E  
Sbjct: 74  RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELA 133

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            G+             F+     S+  R       +G A+       +  YY  +IGW+ 
Sbjct: 134 LGQ-------------FHRCGCLSIWKRICPALKGVGYAICL-IDIYMGMYYNTIIGWAV 179

Query: 131 AYSWFSISGAY--------FNVE---------------STAKFF------ESYLSNHGLV 161
            Y + S +           +N E               S AK F      ESY  N GL 
Sbjct: 180 YYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERKVLESYKGN-GLD 238

Query: 162 FL----------FWGITVVLLAIAVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALG 210
           F+           +G+  VL+  ++ +GV S G   WV  + P    + V++++ V  + 
Sbjct: 239 FMGPVKPTLALCVFGV-FVLVYFSLWKGVRSAGKVVWVTALAP----YVVLIILLVRGVS 293

Query: 211 SPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGP 270
            P         +G ++  +P W  LK     V + A+ QIFF+L  G G +   +SY   
Sbjct: 294 LP------GADEGIKYYLTPEWHKLKNS--KVWIDAASQIFFSLGPGFGTLLALSSYNKF 345

Query: 271 KDDVALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENF 329
            ++     L T S+N     + G  I   L  +AY  K    +V  +G            
Sbjct: 346 NNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGP----------- 394

Query: 330 GLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEE---DLGI 385
             G  +   P     M +   F+  ++FL+L   G  S    +   +TAL +E    +G 
Sbjct: 395 --GLVFIVYPEAIATM-SGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGR 451

Query: 386 SRKTGTWIVFIIYFLLGIPVVYINGYLDQVDAWISFQLALLALFDIIV---GV-WLFKPD 441
            R+    ++    FL  +P +   G +  V+    +   L  LF + V   GV W +  D
Sbjct: 452 RRELFVLLLLAFIFLCALPTMTYGGVV-LVNFLNVYGPGLAILFVVFVEAAGVFWFYGVD 510

Query: 442 NFWKELHEGALINVPEFYKWITVIIAPIFI 471
            F  ++ +        F++     I+P+F+
Sbjct: 511 RFSSDVEQMLGSKPGLFWRICWTYISPVFL 540


>pir||JH0674 L-proline transport protein - rat
           Length = 637
           
 Score = 92.8 bits (227), Expect = 9e-18
 Identities = 112/495 (22%), Positives = 202/495 (40%), Gaps = 78/495 (15%)

Query: 2   DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
           D+G + ++      R  W  K+  +L+  G  +GLGN  RFP +   NGGGAF+VPYFL 
Sbjct: 23  DQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82

Query: 57  LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
           L + GIP+ ++E   G++       +LGP          K   A +  LI G +A     
Sbjct: 83  LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135

Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
           ++     +L       + W    +W++             +GA   N+ ST    E Y S
Sbjct: 136 IIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWS 195

Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
            + L             + W + + LL   + V   + KG++   KV+     + + ++L
Sbjct: 196 RYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255

Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
           ++ V  +  P         KG +F  +P + +L      V + A+ QIF++L +G G + 
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307

Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
            +ASY     ++          N    ++ G +I   L        VP + +AK      
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362

Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
                  G G ++   P     +     F+  L+F +L   G  S  A +   +TA+ +E
Sbjct: 363 -------GPGLAFVIYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414

Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
               L   +   + ++ +  +L+G+ +    G      LD   A  SF L ++ +   + 
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472

Query: 434 GVWLFKPDNFWKELH 448
              ++    F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487


>sp|P28573|NTPR_RAT SODIUM-DEPENDENT PROLINE TRANSPORTER >gi|205235|gb|AAA41541.1|
           (M88111) high affinity L-proline transporter [Rattus
           norvegicus]
           Length = 661
           
 Score = 92.8 bits (227), Expect = 9e-18
 Identities = 112/495 (22%), Positives = 202/495 (40%), Gaps = 78/495 (15%)

Query: 2   DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
           D+G + ++      R  W  K+  +L+  G  +GLGN  RFP +   NGGGAF+VPYFL 
Sbjct: 23  DQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82

Query: 57  LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
           L + GIP+ ++E   G++       +LGP          K   A +  LI G +A     
Sbjct: 83  LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135

Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
           ++     +L       + W    +W++             +GA   N+ ST    E Y S
Sbjct: 136 IIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWS 195

Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
            + L             + W + + LL   + V   + KG++   KV+     + + ++L
Sbjct: 196 RYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255

Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
           ++ V  +  P         KG +F  +P + +L      V + A+ QIF++L +G G + 
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307

Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
            +ASY     ++          N    ++ G +I   L        VP + +AK      
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362

Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
                  G G ++   P     +     F+  L+F +L   G  S  A +   +TA+ +E
Sbjct: 363 -------GPGLAFVIYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414

Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
               L   +   + ++ +  +L+G+ +    G      LD   A  SF L ++ +   + 
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472

Query: 434 GVWLFKPDNFWKELH 448
              ++    F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487


>sp|P31647|NTG3_RAT SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3
           >gi|285089|pir||JH0695 gamma-aminobutyric acid
           transporter protein 3 - rat >gi|202535|gb|AAA40607.1|
           (M95763) GABA transporter [Rattus norvegicus]
           >gi|204220|gb|AAA41183.1| (M95738)
           beta-alanine-sensitive neuronal GABA transporter [Rattus
           norvegicus] >gi|253467|gb|AAB22850.1| (S42358) GABA
           transporter, GAT-B=beta-alanine-sensitive protein [rats,
           midbrain, neurons, Peptide, 627 aa] [Rattus sp.]
           Length = 627
           
 Score = 92.8 bits (227), Expect = 9e-18
 Identities = 118/516 (22%), Positives = 210/516 (39%), Gaps = 96/516 (18%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           + +R  W  K+  +L++AG  IGLGN  RFP     NGGGAF++PY +     GIPV ++
Sbjct: 42  VHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFL 101

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYLH 124
           E   G++  + G              +   R   +F  IG    +AT  +   LN YY+ 
Sbjct: 102 ETALGQFTSEGG-------------ITCWRRVCPLFEGIG----YATQVIEAHLNVYYII 144

Query: 125 LIGWSAAY---------SWFSISGAYFNVESTAKFFESYLSNHGLVFL---------FWG 166
           ++ W+  Y          W +  G  +N E   +F +   SN+  V L         FW 
Sbjct: 145 ILAWAIFYLSNCFTTELPW-ATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWE 203

Query: 167 ITVVLLAIAVGQGVSK-GIERW--------------------VKVMMPLLYV---FAVIL 202
             V    +A+  G+   G  RW                     K    ++YV   F  I+
Sbjct: 204 RRV----LAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIM 259

Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
           ++ +   G  L        +G +F   P+ + L +    V + A  QIFF+ ++ +G + 
Sbjct: 260 LLILLIRGVTLP----GASEGIKFYLYPDLSRLSDP--QVWVDAGTQIFFSYAICLGCLT 313

Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
              SY    ++     +    LN     V G +I   L      + VP   +A+      
Sbjct: 314 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAES----- 368

Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEE 381
                  G G ++ + P   V M      +  L+F++L F G  S  + + + +TA+++ 
Sbjct: 369 -------GPGLAFIAYPKA-VTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM 420

Query: 382 -----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDII 432
                  G  R+     + I+ + LG+ ++   G Y+ Q+ D++ +  + LL  A+F+ +
Sbjct: 421 YPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECV 480

Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP 468
              W++  + F+  + +          KW   ++ P
Sbjct: 481 CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTP 516


>sp|P31650|NTG4_MOUSE SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 4 (GAT4)
           >gi|346710|pir||B44409 gamma-aminobutyric acid
           transporter 4, GAT4 - mouse
           Length = 627
           
 Score = 90.5 bits (221), Expect = 4e-17
 Identities = 118/516 (22%), Positives = 206/516 (39%), Gaps = 96/516 (18%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           + +R  W  K+  +L++AG  IGLGN  RFP     NGGGAF++PY +     GIPV ++
Sbjct: 42  VHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFL 101

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL---LNSYYLH 124
           E   G++  + G              +   R   +F  IG    +AT  +   LN YY+ 
Sbjct: 102 ETALGQFTSEGG-------------ITCWRRVCPLFEGIG----YATQVIEAHLNVYYII 144

Query: 125 LIGWSAAY---------SWFSISGAYFNVESTAKFFESYLSNHGLVFL---------FWG 166
           ++ W+  Y          W +  G  +N E   +F +   SN+  V L         FW 
Sbjct: 145 ILAWAIFYLSNCFTTELPW-ATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWE 203

Query: 167 ITVVLLAIAVGQGVSK-GIERW--------------------VKVMMPLLYV---FAVIL 202
             V    +A+  G+   G  RW                     K    ++YV   F  I+
Sbjct: 204 RRV----LAISDGIEHIGNLRWELALCLLAGWTICYFCIWKGTKSTGKVVYVTATFPYIM 259

Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
           ++ +   G  L        +G +F   P+ + L +    V + A  QIFF+ ++ +G + 
Sbjct: 260 LLILLIRGVTLP----GASEGIKFYLYPDLSRLSDP--QVWVDAGTQIFFSYAICLGCLT 313

Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
              SY    ++     +    LN     V G +I   L      + VP   +A+      
Sbjct: 314 ALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAES----- 368

Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLEE 381
                  G G ++ + P   V M      +  L+F++L F G  S  + + + +TA+++ 
Sbjct: 369 -------GPGLAFIAYPKA-VTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM 420

Query: 382 -----DLGISRKTGTWIVFIIYFLLGIPVVYING-YLDQV---DAWISFQLALLALFDII 432
                  G  R+     + II + LG+ ++   G Y+ Q+    A     L  +A+F+ +
Sbjct: 421 YPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFGSYAASGMCLLFVAIFECV 480

Query: 433 VGVWLFKPDNFWKELHEGALINVPEFYKWITVIIAP 468
              W++  + F+  + +          KW   ++ P
Sbjct: 481 CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTP 516


>gi|7657589 solute carrier family 6 (neurotransmitter transporter, L-proline),
           member 7; brain-specific L-proline transporter [Homo
           sapiens] >gi|3024229|sp|Q99884|NTPR_HUMAN
           SODIUM-DEPENDENT PROLINE TRANSPORTER
           >gi|8176779|gb|AAB47007.2| (S80071) brain-specific
           L-proline transporter [Homo sapiens]
           Length = 636
           
 Score = 90.5 bits (221), Expect = 4e-17
 Identities = 111/495 (22%), Positives = 201/495 (40%), Gaps = 78/495 (15%)

Query: 2   DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
           D+G + ++      R  W  K+  +L+  G  +GLGN  RFP +   NGGGAF+VPYFL 
Sbjct: 23  DQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82

Query: 57  LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
           L + GIP+ ++E   G++       +LGP          K   A +  LI G +A     
Sbjct: 83  LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135

Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
           ++     +L       + W    +W++             +GA   N+  T    E Y S
Sbjct: 136 IIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWS 195

Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
            + L             + W + + LL   + V   + KG++   KV+     + + ++L
Sbjct: 196 RYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255

Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
           ++ V  +  P         KG +F  +P + +L      V + A+ QIF++L +G G + 
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307

Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
            +ASY     ++          N    ++ G +I   L        VP + +AK      
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362

Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
                  G G ++   P     +     F+  L+F +L   G  S  A +   +TA+ +E
Sbjct: 363 -------GPGLAFVVYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414

Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
               L   +   + ++ +  +L+G+ +    G      LD   A  SF L ++ +   + 
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472

Query: 434 GVWLFKPDNFWKELH 448
              ++    F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487


>gi|11416778 solute carrier family 6 (neurotransmitter transporter, L-proline),
           member 7 [Homo sapiens]
           Length = 636
           
 Score = 90.5 bits (221), Expect = 4e-17
 Identities = 111/495 (22%), Positives = 201/495 (40%), Gaps = 78/495 (15%)

Query: 2   DRGVIQME-----QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLA 56
           D+G + ++      R  W  K+  +L+  G  +GLGN  RFP +   NGGGAF+VPYFL 
Sbjct: 23  DQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLM 82

Query: 57  LFLLGIPVMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTT 116
           L + GIP+ ++E   G++       +LGP          K   A +  LI G +A     
Sbjct: 83  LAICGIPLFFLELSLGQF------SSLGPLAVWKISPLFKGAGAAML-LIVGLVAIYYNM 135

Query: 117 LLNSYYLHL-------IGWSAAYSWFSI------------SGAY-FNVESTAKFFESYLS 156
           ++     +L       + W    +W++             +GA   N+  T    E Y S
Sbjct: 136 IIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWS 195

Query: 157 NHGLVF-----------LFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVIL 202
            + L             + W + + LL   + V   + KG++   KV+     + + ++L
Sbjct: 196 RYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILL 255

Query: 203 VIYVFALGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQ 262
           ++ V  +  P         KG +F  +P + +L      V + A+ QIF++L +G G + 
Sbjct: 256 MLLVRGVTLP------GAWKGIQFYLTPQFHHLLSS--KVWIEAALQIFYSLGVGFGGLL 307

Query: 263 NYASYLGPKDDVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAAL 322
            +ASY     ++          N    ++ G +I   L        VP + +AK      
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKA----- 362

Query: 323 QWISENFGLGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIA-MYNYLTALLEE 381
                  G G ++   P     +     F+  L+F +L   G  S  A +   +TA+ +E
Sbjct: 363 -------GPGLAFVVYPQAMTML-PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414

Query: 382 ---DLGISRKTGTWIVFIIYFLLGIPVVYING-----YLDQVDAWISFQLALLALFDIIV 433
               L   +   + ++ +  +L+G+ +    G      LD   A  SF L ++ +   + 
Sbjct: 415 FPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSA--SFGLMVVVITTCLA 472

Query: 434 GVWLFKPDNFWKELH 448
              ++    F +++H
Sbjct: 473 VTRVYGIQRFCRDIH 487


>gi|11434830 solute carrier family 6 (neurotransmitter transporter, GABA),
           member 1 [Homo sapiens]
           Length = 358
           
 Score = 90.1 bits (220), Expect = 6e-17
 Identities = 85/319 (26%), Positives = 131/319 (40%), Gaps = 57/319 (17%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           +  RD W  +   +++  G AIGLGN  RFP     NGGGAF++PYFL L   G+P+  +
Sbjct: 41  LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLL 100

Query: 68  EWVQGRYG--GKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHL 125
           E   G+Y   G  G   L P F  +             GL    L+F     LN YY+ +
Sbjct: 101 ECSLGQYTSIGGLGVWKLAPMFKGV-------------GLAAAVLSF----WLNIYYIVI 143

Query: 126 IGWSAAYSWFSISGAY-----FNVESTAKFFESY-----LSNHGLVFLFW---------- 165
           I W+  Y + S +         N  +T + F +Y      +    V  FW          
Sbjct: 144 ISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDG 203

Query: 166 -----------GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
                       IT+ +  I V   + KG+  W   ++     +  I++I +F  G  L 
Sbjct: 204 LDKPGQIRWPLAITLAIAWILVYFCIWKGV-GWTGKVVYFSATYPYIMLIILFFRGVTLP 262

Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
             +    +G  F  +PN+  L +    V L A+ QIFF+  LG+G +    SY    ++V
Sbjct: 263 GAK----EGILFYITPNFRKLSDS--EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNV 316

Query: 275 ALSGLATVSLNEFAEVVLG 293
               +    +N    +  G
Sbjct: 317 YRDSIIVCCINSCTSMFAG 335


>gb|AAF45873.2| (AE003427) CG10804 gene product [Drosophila melanogaster]
           Length = 662
           
 Score = 89.3 bits (218), Expect = 1e-16
 Identities = 125/540 (23%), Positives = 216/540 (39%), Gaps = 86/540 (15%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           E+R+ W +KI  +LA  G A+GLGN  RFP     NGGGAF+VPYF+ L + GIP+ ++E
Sbjct: 52  EERESWDSKIMFLLATIGYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLE 111

Query: 69  WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
              G+   +   G +G    +         S  + G+  G  +   + ++  YY  +I W
Sbjct: 112 LAIGQ---RLRKGAIGVWSQV---------SPYLGGI--GISSAVVSYIVALYYNTIIAW 157

Query: 129 SAAYSWFSISGAYFNVESTAKFFESYLSNH-------GLVFLFWGITVV----------- 170
              Y   S        +   + ++++  +H            +W  T +           
Sbjct: 158 CLIYLLHSFESPLPWADCPTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPEN 217

Query: 171 --------------LLAIAVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQ 215
                         L+ I + QG+ S G   ++  + P      V+L+I+ F      G 
Sbjct: 218 FNYHMAIALIVSWFLVYICMVQGITSSGKIVYMTAIFPY-----VVLIIFFFR-----GI 267

Query: 216 PQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKD--- 272
                  G   +++P W  L + +  V L A  QIFF+L L  G +  ++SY    +   
Sbjct: 268 TLKGAADGVAHLFTPRWETLLDPV--VWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCY 325

Query: 273 -DVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLA---KGSNAALQWISEN 328
            D  L  L     + FA VV+   I       +         L    K  N  +  +   
Sbjct: 326 RDAILVSLTNCGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTE 385

Query: 329 FGLGFSYTSLPNIF----VQMGTAGRFFGALWFLLLWFAGFTSAI-AMYNYLTALLEEDL 383
                S T L  I     +      + +  L+FL+L+  G  S    +   +T+L++  L
Sbjct: 386 LANSASGTGLAFIIFTEAINQFPGAQLWAVLFFLMLFTLGIDSQFGTLEGVVTSLVDMKL 445

Query: 384 GISRKTGTWIVFIIYFLLGIPVVYING---YLDQ-VDAWI-SFQLALLALFD-----IIV 433
             +      +  + +    I + + NG   Y+ Q +D++  +F L ++ALF+      I 
Sbjct: 446 FPNLPKEYIVGALCFSCCTISMCFANGAGSYIFQLMDSFAGNFPLLIIALFECLSISYIY 505

Query: 434 GVWLFKPDNFWKELHEGALINVPEFYKWITVIIAPIFIALPLFGTFTDLVSKTLGWPAKI 493
           GV  F  D    E+  G+  N    + W    ++P  +   L  +F  L+++   +PA I
Sbjct: 506 GVRRFSDD---IEMMTGSRPNFYWMFCW--KYLSPCAMVTILLASFYQLLTEGSSYPAWI 560


>gb|AAC47292.1| (U66460) inebriated [Drosophila melanogaster]
           Length = 658
           
 Score = 89.3 bits (218), Expect = 1e-16
 Identities = 111/496 (22%), Positives = 200/496 (39%), Gaps = 82/496 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           ++  WA K+  +LA  G ++GLGN  RFP     +GGG F+VPY + LF+  IP++++E 
Sbjct: 51  RQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMEL 110

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y G+   G LG    L                  G  +   + L+++YY  +IG+S
Sbjct: 111 SVGQYTGRGPIGALGQLCPLFKG--------------AGLASVVVSFLMSTYYSVIIGYS 156

Query: 130 AAYSWFSI-----------------------SGAYFNVESTAK-----FFESYL--SNHG 159
             Y + S                         G   +   T++     FFE+ +   + G
Sbjct: 157 IYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGG 216

Query: 160 LVF---LFWGITVVLLA--IAVGQGVSKGIERWVKV-MMPLLYVFAVILVIYVFALGSPL 213
           L +   + W +   L+   + V     K I+   KV      + F +I+++ V A+    
Sbjct: 217 LEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLD- 275

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
                   +G  F + P W+ LK    +V + A+ Q F +L +  G + ++ASY    ++
Sbjct: 276 -----GAAEGLRFFFRPKWSELKNA--NVWINAASQNFNSLGITFGSMISFASYNKYNNN 328

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
           +    +A  ++N    +++G          +A   +    L + +N     I +  G G 
Sbjct: 329 ILRDTVAVSAVNMITSLLVG---------IFAFSTLGNLALEQNTNVR-DVIGD--GPGM 376

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL--GISRKTG- 390
            +   P    +M  A + +  ++F +L   G  S  A+   +   +++     I R  G 
Sbjct: 377 IFVVYPQAMAKMPYA-QLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 435

Query: 391 ----TWIVFIIYFLLGIPVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNF 443
                  V +I  L G+P +   G  Y   +D +  S  +  LA   +I   W +     
Sbjct: 436 HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 495

Query: 444 WKELHEGALINVPEFY 459
            K + +      P FY
Sbjct: 496 SKNVKQ-MTGKAPSFY 510


>emb|CAA69649.1| (Y08362) neurotransmitter transporter [Drosophila melanogaster]
           Length = 943
           
 Score = 89.3 bits (218), Expect = 1e-16
 Identities = 111/496 (22%), Positives = 200/496 (39%), Gaps = 82/496 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           ++  WA K+  +LA  G ++GLGN  RFP     +GGG F+VPY + LF+  IP++++E 
Sbjct: 336 RQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMEL 395

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y G+   G LG    L                  G  +   + L+++YY  +IG+S
Sbjct: 396 SVGQYTGRGPIGALGQLCPLFKG--------------AGLASVVVSFLMSTYYSVIIGYS 441

Query: 130 AAYSWFSI-----------------------SGAYFNVESTAK-----FFESYL--SNHG 159
             Y + S                         G   +   T++     FFE+ +   + G
Sbjct: 442 IYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGG 501

Query: 160 LVF---LFWGITVVLLA--IAVGQGVSKGIERWVKV-MMPLLYVFAVILVIYVFALGSPL 213
           L +   + W +   L+   + V     K I+   KV      + F +I+++ V A+    
Sbjct: 502 LEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLD- 560

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
                   +G  F + P W+ LK    +V + A+ Q F +L +  G + ++ASY    ++
Sbjct: 561 -----GAAEGLRFFFRPKWSELKNA--NVWINAASQNFNSLGITFGSMISFASYNKYNNN 613

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
           +    +A  ++N    +++G          +A   +    L + +N     I +  G G 
Sbjct: 614 ILRDTVAVSAVNMITSLLVG---------IFAFSTLGNLALEQNTNVR-DVIGD--GPGM 661

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL--GISRKTG- 390
            +   P    +M  A + +  ++F +L   G  S  A+   +   +++     I R  G 
Sbjct: 662 IFVVYPQAMAKMPYA-QLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 720

Query: 391 ----TWIVFIIYFLLGIPVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNF 443
                  V +I  L G+P +   G  Y   +D +  S  +  LA   +I   W +     
Sbjct: 721 HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 780

Query: 444 WKELHEGALINVPEFY 459
            K + +      P FY
Sbjct: 781 SKNVKQ-MTGKAPSFY 795


>gb|AAF51001.1| (AE003576) ine gene product [Drosophila melanogaster]
           Length = 943
           
 Score = 89.3 bits (218), Expect = 1e-16
 Identities = 111/496 (22%), Positives = 200/496 (39%), Gaps = 82/496 (16%)

Query: 10  QRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEW 69
           ++  WA K+  +LA  G ++GLGN  RFP     +GGG F+VPY + LF+  IP++++E 
Sbjct: 336 RQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMEL 395

Query: 70  VQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWS 129
             G+Y G+   G LG    L                  G  +   + L+++YY  +IG+S
Sbjct: 396 SVGQYTGRGPIGALGQLCPLFKG--------------AGLASVVVSFLMSTYYSVIIGYS 441

Query: 130 AAYSWFSI-----------------------SGAYFNVESTAK-----FFESYL--SNHG 159
             Y + S                         G   +   T++     FFE+ +   + G
Sbjct: 442 IYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGG 501

Query: 160 LVF---LFWGITVVLLA--IAVGQGVSKGIERWVKV-MMPLLYVFAVILVIYVFALGSPL 213
           L +   + W +   L+   + V     K I+   KV      + F +I+++ V A+    
Sbjct: 502 LEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLD- 560

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
                   +G  F + P W+ LK    +V + A+ Q F +L +  G + ++ASY    ++
Sbjct: 561 -----GAAEGLRFFFRPKWSELKNA--NVWINAASQNFNSLGITFGSMISFASYNKYNNN 613

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGF 333
           +    +A  ++N    +++G          +A   +    L + +N     I +  G G 
Sbjct: 614 ILRDTVAVSAVNMITSLLVG---------IFAFSTLGNLALEQNTNVR-DVIGD--GPGM 661

Query: 334 SYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDL--GISRKTG- 390
            +   P    +M  A + +  ++F +L   G  S  A+   +   +++     I R  G 
Sbjct: 662 IFVVYPQAMAKMPYA-QLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGY 720

Query: 391 ----TWIVFIIYFLLGIPVVYING--YLDQVDAW-ISFQLALLALFDIIVGVWLFKPDNF 443
                  V +I  L G+P +   G  Y   +D +  S  +  LA   +I   W +     
Sbjct: 721 HEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 780

Query: 444 WKELHEGALINVPEFY 459
            K + +      P FY
Sbjct: 781 SKNVKQ-MTGKAPSFY 795


>gi|8394204 X transporter protein 2 [Rattus norvegicus]
           >gi|531469|gb|AAC13771.1| (U12973) renal osmotic
           stress-induced Na-Cl organic solute cotransporter
           [Rattus norvegicus] >gi|1092855|prf||2102185A ROSIT
           [Rattus norvegicus]
           Length = 615
           
 Score = 88.9 bits (217), Expect = 1e-16
 Identities = 88/318 (27%), Positives = 140/318 (43%), Gaps = 52/318 (16%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MD  V   ++R KW  K+  +L+  G A+GLGN  RFP     +GGGAF++PYF+AL   
Sbjct: 7   MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFE 66

Query: 61  GIPVMWVEWVQGR---------------YGGKYGHGTLGPTFYLMARESLKPRSALIFGL 105
           GIP+ ++E   G+               Y G  G G    +F +          +L +  
Sbjct: 67  GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLV----------SLYYNT 116

Query: 106 IGGALAFATTTLLNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYL 155
           I   L +     LNS+  H + WS      + +G     +S  T  +F         S +
Sbjct: 117 I---LLWVLWFFLNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDI 172

Query: 156 SNHGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSP 212
           SN G +   W + + L+A    V   V +GIE   KV+    L+ + V+ +  +  L  P
Sbjct: 173 SNTGTI--QWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP 230

Query: 213 LGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKD 272
                    +G  ++++PN   L+     V L A+ QIFF+LSL  G    +ASY  P++
Sbjct: 231 ------GATEGLTYLFTPNMKILQNS--RVWLDAATQIFFSLSLAFGGHIAFASYNQPRN 282

Query: 273 DVALSGLATVSLNEFAEV 290
           +     +    +N    +
Sbjct: 283 NCEKDAVTIALVNSMTSL 300


>gb|AAF98299.1|AF237673_1 (AF237673) norepinephrine transporter [Gallus gallus]
           Length = 635
           
 Score = 88.5 bits (216), Expect = 2e-16
 Identities = 125/555 (22%), Positives = 230/555 (40%), Gaps = 89/555 (16%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           + R+ W  KI  +L++ G A+ L N  RFP     NGGGAF++PY L L + G+P+ ++E
Sbjct: 72  QDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYILFLIIAGMPLFYME 131

Query: 69  WVQGRYGGKYGHGT---LGPTFYLMARESLKPRSALIFGLIGGA-LAFATTTLLNSYYLH 124
              G+Y  + G  T   + P F  +    +    AL  G      +A++   L +S+   
Sbjct: 132 LALGQY-NREGAATVWKICPVFKGVGYAVI--LIALYVGFYYNVIIAWSLYYLFSSFTFE 188

Query: 125 LIGWSAAYSW------------FSISG-----AYFNVESTAKFFESYLSN-------HGL 160
           L   +   SW             S+ G     + + +   A+F+E  + +       H L
Sbjct: 189 LPWTNCDNSWNSPNCTDPKLFNASVLGNGTKYSKYKLTPAAEFYERGVLHLHESRGIHDL 248

Query: 161 VFLFWGITVVLLAIAV------GQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALGSPL 213
               W +++ LL + +       +GV + G   W+   +P  YV   +L+I+   L    
Sbjct: 249 GLPRWQLSLCLLVVVIILFFSLWKGVKTSGKVVWITATLP--YVVLFVLLIHGITLP--- 303

Query: 214 GQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD 273
                    G       ++  LKE   +V + A+ QIF++L  G G++  +ASY    ++
Sbjct: 304 -----GAYNGINAYLHIDFRRLKEA--TVWIDAATQIFYSLGAGFGVLIAFASYNKFDNN 356

Query: 274 VALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENFGLG 332
                L T ++N     + G +I   L  +A+  K+   +V  +G+             G
Sbjct: 357 CYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGA-------------G 403

Query: 333 FSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGI---SRKT 389
             +   P     + +   F+  ++F++L   G  S++     +   L +D  I    RK 
Sbjct: 404 LVFILYPEAISTL-SGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFHILKQHRKL 462

Query: 390 GTWIVFIIYFLLGIPVVYING--YLDQVDAWISFQLALLALFDIIVGV-WLFKPDNFWKE 446
            T+ V    FLL +  +   G   L  +D + +    L A+    +GV W +  D F ++
Sbjct: 463 FTFGVSFGTFLLALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSED 522

Query: 447 LHEGALINVPEFYKWITVIIAPIFIAL----------PLFGTFTDLV----SKTLGWPAK 492
           + +        +++     ++P F+            PL  T+ D      +  +GW   
Sbjct: 523 IQQMMGFKPGLYWRLCWKFVSPAFLLFVVIVSIINFKPL--TYDDYTFPFWANRIGW--G 578

Query: 493 IAIIAMLIIGAIEAY 507
           IA+ +M+++ A   Y
Sbjct: 579 IALSSMILVPAYVIY 593


>gb|AAC27757.1| (AF075262) orphan transporter isoform A12 [Mus musculus]
           Length = 615
           
 Score = 87.8 bits (214), Expect = 3e-16
 Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MD  V   ++R KW  K+  +L+  G A+GLGN  RFP     +GGGAF++PYF+AL   
Sbjct: 7   MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66

Query: 61  GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
           GIP+ ++E   G   R G      T+ P    +        S L+       L +     
Sbjct: 67  GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125

Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
           LNS+  H + WS      + +G     +S  T  +F         S +SN G +   W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182

Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
            + L+A    V   V +GIE   KV+    L+ + V+ +  +  L  P         +G 
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236

Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
            ++++PN   L+     V L A+ QIFF+LSL  G    +ASY  P+++     +    +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294

Query: 285 NEFAEVVLGGSIAV 298
           N      L  SIA+
Sbjct: 295 NSMTS--LYASIAI 306


>gb|AAC27758.1| (AF075263) orphan transporter isoform A11 [Mus musculus]
           Length = 605
           
 Score = 87.8 bits (214), Expect = 3e-16
 Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MD  V   ++R KW  K+  +L+  G A+GLGN  RFP     +GGGAF++PYF+AL   
Sbjct: 7   MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66

Query: 61  GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
           GIP+ ++E   G   R G      T+ P    +        S L+       L +     
Sbjct: 67  GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125

Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
           LNS+  H + WS      + +G     +S  T  +F         S +SN G +   W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182

Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
            + L+A    V   V +GIE   KV+    L+ + V+ +  +  L  P         +G 
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236

Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
            ++++PN   L+     V L A+ QIFF+LSL  G    +ASY  P+++     +    +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294

Query: 285 NEFAEVVLGGSIAV 298
           N      L  SIA+
Sbjct: 295 NSMTS--LYASIAI 306


>gb|AAC27759.1| (AF075264) orphan transporter isoform B11 [Mus musculus]
           Length = 577
           
 Score = 87.8 bits (214), Expect = 3e-16
 Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MD  V   ++R KW  K+  +L+  G A+GLGN  RFP     +GGGAF++PYF+AL   
Sbjct: 7   MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66

Query: 61  GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
           GIP+ ++E   G   R G      T+ P    +        S L+       L +     
Sbjct: 67  GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125

Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
           LNS+  H + WS      + +G     +S  T  +F         S +SN G +   W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182

Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
            + L+A    V   V +GIE   KV+    L+ + V+ +  +  L  P         +G 
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236

Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
            ++++PN   L+     V L A+ QIFF+LSL  G    +ASY  P+++     +    +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294

Query: 285 NEFAEVVLGGSIAV 298
           N      L  SIA+
Sbjct: 295 NSMTS--LYASIAI 306


>gb|AAC27760.1| (AF075265) orphan transporter isoform A10 [Mus musculus]
           Length = 552
           
 Score = 87.8 bits (214), Expect = 3e-16
 Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MD  V   ++R KW  K+  +L+  G A+GLGN  RFP     +GGGAF++PYF+AL   
Sbjct: 7   MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66

Query: 61  GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
           GIP+ ++E   G   R G      T+ P    +        S L+       L +     
Sbjct: 67  GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125

Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
           LNS+  H + WS      + +G     +S  T  +F         S +SN G +   W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182

Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
            + L+A    V   V +GIE   KV+    L+ + V+ +  +  L  P         +G 
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236

Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
            ++++PN   L+     V L A+ QIFF+LSL  G    +ASY  P+++     +    +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294

Query: 285 NEFAEVVLGGSIAV 298
           N      L  SIA+
Sbjct: 295 NSMTS--LYASIAI 306


>gb|AAC27761.1| (AF075266) orphan transporter isoform B9 [Mus musculus]
           Length = 514
           
 Score = 87.8 bits (214), Expect = 3e-16
 Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MD  V   ++R KW  K+  +L+  G A+GLGN  RFP     +GGGAF++PYF+AL   
Sbjct: 7   MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66

Query: 61  GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
           GIP+ ++E   G   R G      T+ P    +        S L+       L +     
Sbjct: 67  GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125

Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
           LNS+  H + WS      + +G     +S  T  +F         S +SN G +   W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182

Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
            + L+A    V   V +GIE   KV+    L+ + V+ +  +  L  P         +G 
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236

Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
            ++++PN   L+     V L A+ QIFF+LSL  G    +ASY  P+++     +    +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294

Query: 285 NEFAEVVLGGSIAV 298
           N      L  SIA+
Sbjct: 295 NSMTS--LYASIAI 306


>gi|6756029 X transporter protein 2 [Mus musculus] >gi|3347932|gb|AAC27762.1|
           (AF075267) orphan transporter isoform A8 [Mus musculus]
           Length = 422
           
 Score = 87.8 bits (214), Expect = 3e-16
 Identities = 91/314 (28%), Positives = 141/314 (43%), Gaps = 30/314 (9%)

Query: 1   MDRGVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLL 60
           MD  V   ++R KW  K+  +L+  G A+GLGN  RFP     +GGGAF++PYF+AL   
Sbjct: 7   MDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFE 66

Query: 61  GIPVMWVEWVQG---RYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTL 117
           GIP+ ++E   G   R G      T+ P    +        S L+       L +     
Sbjct: 67  GIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSV-SFLVSLYYNTVLLWVLWFF 125

Query: 118 LNSYYLHLIGWSAAYSWFSISGAYFNVES--TAKFF--------ESYLSNHGLVFLFWGI 167
           LNS+  H + WS      + +G     +S  T  +F         S +SN G +   W +
Sbjct: 126 LNSFQ-HPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTI--QWKL 182

Query: 168 TVVLLAI--AVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWSTIKGF 224
            + L+A    V   V +GIE   KV+    L+ + V+ +  +  L  P         +G 
Sbjct: 183 FLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLP------GATEGL 236

Query: 225 EFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSL 284
            ++++PN   L+     V L A+ QIFF+LSL  G    +ASY  P+++     +    +
Sbjct: 237 IYLFTPNMKTLQNP--RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALV 294

Query: 285 NEFAEVVLGGSIAV 298
           N      L  SIA+
Sbjct: 295 NSMTS--LYASIAI 306


>gb|AAF89166.1|AF230787_1 (AF230787) norepinephrine transporter [Coturnix japonica]
           Length = 515
           
 Score = 86.6 bits (211), Expect = 6e-16
 Identities = 122/553 (22%), Positives = 224/553 (40%), Gaps = 99/553 (17%)

Query: 12  DKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQ 71
           + W  KI  +L++ G A+ L N  RFP     NGGGAF++PY L L + G+P+ ++E   
Sbjct: 1   ENWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYILFLIIAGMPLFYMELAL 60

Query: 72  GRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAA 131
           G+Y  + G  T+              +   +F  +G A+       +  YY  +I WS  
Sbjct: 61  GQY-NREGAATVW-------------KICPVFKGVGYAV-ILIALYVGFYYNVIIAWSLY 105

Query: 132 Y---------SWFSISGAYFNVEST-AKFFESYLSNHGLVFLFWGITVV-------LLAI 174
           Y          W +   ++ N   T  K F + +  +G  +  + +T         +L +
Sbjct: 106 YLFSSFTFELPWTNCDNSWNNPNCTNPKLFNASVLGNGTKYSKYKLTPAAEFYERGVLHL 165

Query: 175 AVGQGV-SKGIERWVKVMMPLLYVFAVILVIYVFALGSPL---GQPQWST---------- 220
              +G+   G+ RW      L     V+++I  F+L   +   G+  W T          
Sbjct: 166 HESRGIHDLGLPRW-----QLSLCLLVVVIILFFSLWKGVKTSGKVVWITATLPYVVLFV 220

Query: 221 --IKGFEFIWSPNWTYLKEHL-------WSVMLAASGQIFFTLSLGMGIIQNYASYLGPK 271
             I G     + N      H+        +V + A+ QIF++L  G G++  +ASY    
Sbjct: 221 LLIHGITLPGAYNGINAYLHIDFRRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNRFD 280

Query: 272 DDVALSGLATVSLNEFAEVVLGGSIAVPLA-VAYAPKIVPPEVLAKGSNAALQWISENFG 330
           ++     L T ++N     + G +I   L  +A+  K+   +V  +G+            
Sbjct: 281 NNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGA------------ 328

Query: 331 LGFSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGI---SR 387
            G  +   P     + +   F+  ++F++L   G  S++     +   L +D  I    R
Sbjct: 329 -GLVFILYPEAISTL-SGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFHILKQHR 386

Query: 388 KTGTWIVFIIYFLLGIPVVYING--YLDQVDAWISFQLALLALFDIIVGV-WLFKPDNFW 444
           K  T+ V    FLL +  +   G   L  +D + +    L A+    +G+ W +  D F 
Sbjct: 387 KLFTFGVSFGTFLLALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGISWFYGVDRFS 446

Query: 445 KELHEGALINVPEFYKWITVIIAPIFIAL----------PLFGTFTD----LVSKTLGWP 490
           +++ +        +++     ++P F+            PL  T+ D    L +  +GW 
Sbjct: 447 EDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVIVSIINFKPL--TYDDYTFPLWANRIGW- 503

Query: 491 AKIAIIAMLIIGA 503
             IA+ +ML++ A
Sbjct: 504 -GIALSSMLLVPA 515


>pir||S46260 creatine transporter - marbled electric ray
           >gi|541754|emb|CAA54512.1| (X77306) creatine transporter
           [Torpedo marmorata]
           Length = 611
           
 Score = 83.1 bits (202), Expect = 7e-15
 Identities = 103/507 (20%), Positives = 194/507 (37%), Gaps = 84/507 (16%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R  W+ ++  I++  G A+GLGN  RFP     NGGG F++PY L     GIP+ ++E  
Sbjct: 36  RVTWSRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLVAVFGGIPIFFLEIS 95

Query: 71  QGRY--GGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
            G++   G      + P F  +   S+     ++F               N+YY+ ++ W
Sbjct: 96  LGQFMKAGGINAWNIAPLFKGLGYASM----VIVF-------------FCNTYYILVLTW 138

Query: 129 SAAY----------------SWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLL 172
           S+ Y                +W + +       ++ + +         +  FW   V+ L
Sbjct: 139 SSFYLVQSFSSPLPWASCNNTWNTAACYEAGANASTEIYPPTAPAQSSIVQFWERRVLRL 198

Query: 173 AIAVGQGVSKGIE-----------------RWVKVMMPLLYV---FAVILVIYVFALGSP 212
           +  +G     G E                 + VK    ++YV   F  I+++ +   G  
Sbjct: 199 SSGLGDVGEIGWELTLCLTATWMLVYFCIWKGVKTSGKVVYVTATFPYIILVILLVRGVT 258

Query: 213 LGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKD 272
           L       ++G  +   P+W  L E    V + A  QIFF+ ++G+G +    SY    +
Sbjct: 259 L----HGAVQGIVYYLQPDWGKLGEA--QVWIDAGTQIFFSYAIGLGTLTALGSYNQLHN 312

Query: 273 DVALSGLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLG 332
           D          +N       G  +   L      + V   V+A+             G G
Sbjct: 313 DCYKDAFILSLVNSATSFFAGLVVFSILGFMAVEEGVDISVVAES------------GPG 360

Query: 333 FSYTSLPNIFVQMGTAGRFFGALWFLLLWFAGFTSA-IAMYNYLTALLE-----EDLGIS 386
            ++ + P   V +    + +  L+F++L   G  S  + +  ++TA+L+           
Sbjct: 361 LAFIAYPKA-VTLMPFPQVWAVLFFIMLLCLGLGSQFVGVEGFVTAILDLWPSKFSFRYL 419

Query: 387 RKTGTWIVFIIYFLLGIPVVYING-YLDQVDAWISFQ---LALLALFDIIVGVWLFKPDN 442
           R+    +V  + FL+ + ++   G Y+ Q+  + S     L   A ++ +   W++  D 
Sbjct: 420 REVVVAMVICLSFLIDLSMITEGGMYIFQIFDYYSASGTTLLWTAFWECVAVAWVYGGDR 479

Query: 443 FWKELHEGALINVPEFYKWITVIIAPI 469
           +  +L            KW   +I P+
Sbjct: 480 YLDDLAWMLGYRPWALVKWCWSVITPL 506


>pir||T20052 hypothetical protein C49C3.1 - Caenorhabditis elegans
           >gi|3875071|emb|CAB05153.1| (Z82264) predicted using
           Genefinder~contains similarity to Pfam domain: PF00209
           (Sodium:neurotransmitter symporter family), Score=403.1,
           E-value=8.9e-118, N=2~cDNA EST yk7b9.5 comes from this
           gene~cDNA EST yk7b9.3 comes from this gene~cDNA EST
           yk133e6.>
           Length = 706
           
 Score = 82.3 bits (200), Expect = 1e-14
 Identities = 43/122 (35%), Positives = 68/122 (55%), Gaps = 14/122 (11%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R  W  +I  +L+  G A+GLGN  RFPT+   NGG AF+VPY     L G+P +++E++
Sbjct: 44  RGAWGNQIEFLLSTLGMAVGLGNIWRFPTRAYNNGGSAFLVPYVACALLFGLPAVYLEFL 103

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            G+Y     H T  P  +       +  + ++ G+  G +A A ++L+  YY+ +IGWS 
Sbjct: 104 LGQY-----HRTTAPIIF-------RRFAPILQGV--GWMAVAVSSLVAIYYIIIIGWST 149

Query: 131 AY 132
            Y
Sbjct: 150 VY 151


>gi|11436405 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
           Length = 733
           
 Score = 81.9 bits (199), Expect = 2e-14
 Identities = 74/299 (24%), Positives = 128/299 (42%), Gaps = 60/299 (20%)

Query: 7   QMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMW 66
           Q++ R +W  K+  +L++AG  IGLGN  RFP     NGGGAF +PYF+  F+ GIPV +
Sbjct: 52  QVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFF 111

Query: 67  VEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLI 126
           +E   G+Y  +           + A   + P   L  G+  G  +    + LN YY+ ++
Sbjct: 112 LEVALGQYTSQGS---------VTAWRKICP---LFQGI--GLASVVIESYLNVYYIIIL 157

Query: 127 GWSAAYSWFSISGA--------YFNVESTAKF-----------FESYLSN---------- 157
            W+  Y + S +          ++N E    F           FE++ S           
Sbjct: 158 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVL 217

Query: 158 ------HGLVFLFWGITVVLLA--IAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFA 208
                 H L  L W + + LL   +     + KG++   KV+     + + +++++ +  
Sbjct: 218 GITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRG 277

Query: 209 LGSPLGQPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASY 267
           +  P         +G  +   P+   LK+    V + A  QIFF+ ++  G +    SY
Sbjct: 278 VTLP------GAYQGIIYYLKPDLFRLKDP--QVWMDAGTQIFFSFAICQGCLTALGSY 328


>gi|11436403 solute carrier family 6 (neurotransmitter transporter, GABA),
           member 13 [Homo sapiens]
           Length = 574
           
 Score = 81.5 bits (198), Expect = 2e-14
 Identities = 112/481 (23%), Positives = 202/481 (41%), Gaps = 94/481 (19%)

Query: 17  KIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYGG 76
           K+  +L++AG  IGLGN  RFP     NGGGAF +PY + LF  GIPV  +E   G+Y  
Sbjct: 20  KMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTS 79

Query: 77  KYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWFS 136
           + G         + A   + P    IF  IG A +     LLN YY+ ++ W+  Y + S
Sbjct: 80  QGG---------VTAWRKICP----IFEGIGYA-SQMIVILLNVYYIIVLAWALFYLFSS 125

Query: 137 IS------GAY--FNVESTAKFFESYLSNHGL-------VFLFW---------------- 165
            +      G Y  +N E   +F ++  S +G        V  FW                
Sbjct: 126 FTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGA 185

Query: 166 -----GITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWS 219
                 + ++L  +     + KG++   KV+     + + +++V+ +  +  P       
Sbjct: 186 LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLP------G 239

Query: 220 TIKGFEFIWSPNWTYLKEHLW--SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALS 277
             +G +F   PN T     LW   V + A  QIFF+ ++ +G +    SY     +   S
Sbjct: 240 AAQGIQFYLYPNLT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGSY-NKYHNNCYS 294

Query: 278 GLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTS 337
           G + V+         G +I   L      + VP   +A+             G G ++ +
Sbjct: 295 GTSFVA---------GFAIFSILGFMSQEQGVPISEVAES------------GPGLAFIA 333

Query: 338 LPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFI- 396
            P   V +  +  +    +F+++     +  + + + +TAL++    + RK     V I 
Sbjct: 334 YPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLIL 393

Query: 397 ----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFKPDNFWKELH 448
               + FL+G+ ++   G Y+ Q+ D + +  + LL  A+F+ +   W++    F+  + 
Sbjct: 394 GVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIE 453

Query: 449 E 449
           +
Sbjct: 454 D 454


>emb|CAB60372.1| (AL110485) contains similarity to Pfam domain: PF00209
           (Sodium:neurotransmitter symporter family), Score=325.2,
           E-value=2.4e-94, N=2~cDNA EST yk129c9.5 comes from this
           gene; cDNA EST yk144g8.5 comes from this gene~cDNA EST
           yk161h5.5 comes from this gen>
           Length = 714
           
 Score = 81.1 bits (197), Expect = 3e-14
 Identities = 103/463 (22%), Positives = 178/463 (38%), Gaps = 116/463 (25%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           E+RD +      +L   G A+GLGN  RFPT+   NGG AF++PY    FL G+P ++ E
Sbjct: 70  EKRDGFGNSFEFVLTSLGLAVGLGNIWRFPTRAYNNGGSAFLIPYLTCAFLFGLPAVYFE 129

Query: 69  WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
           ++ G+Y GK       P  +   R  L+       G+  G +      L+  YY+ ++ W
Sbjct: 130 FLTGQYQGK-----SPPVIFRRVRPILE-------GV--GWMGVFVAALVAIYYIVIVSW 175

Query: 129 SAAYS----------WFSISGAYFNVESTAKFFESYL-SNHGLVF---LFWGITVVL--- 171
            + Y           W   +  + N  S     + YL  NH  V      W  ++ +   
Sbjct: 176 ISIYMINICRGHFALWSHCNNDWNNGTSCITMADQYLCKNHTKVMANSTLWNSSLPIPDK 235

Query: 172 -------LAIAVGQGVSKGIERW------------------------------------- 187
                     A G  VS   E++                                     
Sbjct: 236 MVYFNGACQDANGTDVSTATEQYFMTYIVQPSSGMLDFGGFNWPVFAAMSVCWLLTGLGI 295

Query: 188 ---VKVMMPLLYV-----FAVILVIY---VFALGSPLGQPQWSTIKGFEFIWSPNWTYLK 236
               K+M  + YV     + +++V++   VF  GS +G           +  +PN+T L 
Sbjct: 296 LKGAKIMGKISYVSVLVPYVLVVVLFINGVFQDGSGVGLEM--------YFGTPNYTKLY 347

Query: 237 EH-LWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATVSLNEFAEVVLGGS 295
           E   W+  L    Q+ F+LS+G G + + +SY   ++++    L  +  +    +V GG+
Sbjct: 348 EQDTWTEALK---QLCFSLSVGHGGLISLSSYSPKRNNIFRDALIVIIGDTTMSLVGGGA 404

Query: 296 IAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTSLPNIFVQMGTAGRFFGAL 355
           +   L   Y  K V   V +              GL  ++   P    +M      +  +
Sbjct: 405 VFATL--GYLAKDVKDVVKS--------------GLSLAFVVYPEAMTRMPVPW-LWCFI 447

Query: 356 WFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFIIY 398
           +FL+L+  G ++ IA+ +   + + +     R    WIV I +
Sbjct: 448 FFLMLFLLGASTEIALVDVFCSCIYDQYPRFRNR-KWIVVIAW 489


>gb|AAF70819.1|AF141930_1 (AF141930) high affinity GABA transporter [Trichoplusia ni]
           Length = 608
           
 Score = 80.8 bits (196), Expect = 4e-14
 Identities = 48/130 (36%), Positives = 69/130 (52%), Gaps = 15/130 (11%)

Query: 8   MEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWV 67
           + +R  W +K+  IL++ G AIGLGN  RFP     NGGGAF++PYFL LFL GIP+ ++
Sbjct: 32  LPERGSWGSKLDFILSVIGLAIGLGNVWRFPYLCYKNGGGAFLIPYFLTLFLAGIPMFFM 91

Query: 68  EWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIG 127
           E   G+     G G                + A IF  IG A A   +  +N YY+ ++ 
Sbjct: 92  ELAMGQMLTIGGLGVF--------------KIAPIFKGIGYAAA-VMSCWMNVYYIVILA 136

Query: 128 WSAAYSWFSI 137
           W+  Y + S+
Sbjct: 137 WAIFYFFMSM 146


>gi|7705539 solute carrier family 6 (neurotransmitter transporter, GABA),
           member 13; GABA transport protein [Homo sapiens]
           >gi|7579920|gb|AAF64247.1| (U76343) GABA transport
           protein [Homo sapiens]
           Length = 569
           
 Score = 78.8 bits (191), Expect = 1e-13
 Identities = 111/481 (23%), Positives = 201/481 (41%), Gaps = 94/481 (19%)

Query: 17  KIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWVQGRYGG 76
           K+  +L++AG  IGLGN  RFP     NGGGAF +PY + LF  GIPV  +E   G+Y  
Sbjct: 20  KMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTS 79

Query: 77  KYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSAAYSWFS 136
           + G         + A   + P    IF  IG A +     LLN YY+ ++ W+  Y + S
Sbjct: 80  QGG---------VTAWRKICP----IFEGIGYA-SQMIVILLNVYYIIVLAWALFYLFSS 125

Query: 137 IS------GAY--FNVESTAKFFESYLSNHGL-------VFLFW---------------- 165
            +      G Y  +N E   +F ++  S +G        V  FW                
Sbjct: 126 FTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGA 185

Query: 166 -----GITVVLLAIAVGQGVSKGIERWVKVM-MPLLYVFAVILVIYVFALGSPLGQPQWS 219
                 + ++L  +     + KG++   KV+     + + +++V+ +  +  P       
Sbjct: 186 LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLP------G 239

Query: 220 TIKGFEFIWSPNWTYLKEHLW--SVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALS 277
             +G +F   PN T     LW   V + A  QIFF+ ++ +G +    SY     +   S
Sbjct: 240 AAQGIQFYLYPNLT----RLWDPQVWMDAGTQIFFSFAICLGCLTALGSY-NKYHNNCYS 294

Query: 278 GLATVSLNEFAEVVLGGSIAVPLAVAYAPKIVPPEVLAKGSNAALQWISENFGLGFSYTS 337
           G + V+         G +I   L      + VP   +A+             G G ++ +
Sbjct: 295 GTSFVA---------GFAIFSILGFMSQEQGVPISEVAES------------GPGLAFIA 333

Query: 338 LPNIFVQMGTAGRFFGALWFLLLWFAGFTSAIAMYNYLTALLEEDLGISRKTGTWIVFI- 396
            P   V +  +  +    +F+++     +  + + + +TAL++    + RK     V I 
Sbjct: 334 YPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLIL 393

Query: 397 ----IYFLLGIPVVYING-YLDQV-DAWISFQLALL--ALFDIIVGVWLFKPDNFWKELH 448
               + F +G+ ++   G Y+ Q+ D + +  + LL  A+F+ +   W++    F+  + 
Sbjct: 394 GVSVVSFPVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIE 453

Query: 449 E 449
           +
Sbjct: 454 D 454


>emb|CAB42788.1| (AL034411) dJ808P6.1 (novel Sodium:neurotransmitter symporter
           family protein) [Homo sapiens]
           Length = 245
           
 Score = 75.7 bits (183), Expect = 1e-12
 Identities = 56/199 (28%), Positives = 98/199 (49%), Gaps = 17/199 (8%)

Query: 9   EQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVE 68
           + R  W+ K   +L+M G A+GLGN  RFP     NGGGAF++PY + L L G+P+ ++E
Sbjct: 34  QDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLE 93

Query: 69  WVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGW 128
              G++       +LGP        S+     L  G+  G      +  +  YY  +I +
Sbjct: 94  CSLGQF------ASLGPV-------SVWRILPLFQGV--GITMVLISIFVTIYYNVIIAY 138

Query: 129 SAAYSWFSISGAYFNVESTAKFFESYLSNHGLVFLFWGITVVLLAIAVGQGVSKGIERWV 188
           S  Y + S   +    ++ A    S ++  G++  +  + ++L  + VG  + KGI+   
Sbjct: 139 SLYYMFASFQ-SELPWKNLALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSG 197

Query: 189 KVM-MPLLYVFAVILVIYV 206
           KV+    L+ + V+L++ V
Sbjct: 198 KVVYFTALFPYVVLLILLV 216


>gb|AAF59549.1| (AC024812) contains similarity to SW:NTSE_DROME [Caenorhabditis
           elegans]
           Length = 645
           
 Score = 74.5 bits (180), Expect = 3e-12
 Identities = 76/303 (25%), Positives = 130/303 (42%), Gaps = 73/303 (24%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           RDKWATK+  +LA+ G A+ LGN  RFP+    +GGGAF++PYF+ L + G+P+ ++E V
Sbjct: 75  RDKWATKMEFLLAVVGYAVDLGNIWRFPSVCYKHGGGAFLIPYFIMLMIGGLPMFYMELV 134

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALA--------FATTTLLNSYY 122
            G+             F+     S+  +   +F  IG  +         F    +  + Y
Sbjct: 135 LGQ-------------FHRSGCVSIWRKVCPLFRGIGYGICCICTFIAIFYNAIIAQAVY 181

Query: 123 LHLIG----WSAAYSWFSISGAYFNVESTAKFFESYLSNHGL--------VFLF------ 164
             ++     W +   W S  G  +N    +      +S +G          +L+      
Sbjct: 182 FAIVSLSKIWDSEVPWAS-CGNPWNTPRCSDDLNVTISRNGTPLTTPSEEYYLYKVLEVQ 240

Query: 165 ------------WGITVVLLAI------AVGQG-VSKGIERWVKVMMPLLYVFAVILVIY 205
                         + V LLA+      A+ +G  S G   WV    P + + +++L+  
Sbjct: 241 KSTGFDDLGGVKTSMAVCLLAVFIMVYFALWKGPQSSGKIVWVTATAPYI-ILSILLIRG 299

Query: 206 VFALGSPLGQPQWSTIKGFEFIWSPNWTYLKE-HLWSVMLAASGQIFFTLSLGMGIIQNY 264
           +   G+           G  +  +P++  LK+  +WS   AA+ QIFF+L  G G++   
Sbjct: 300 LLLPGAK---------NGLYYYVTPDFEKLKDPAVWS---AAATQIFFSLGPGFGVLLAL 347

Query: 265 ASY 267
           +SY
Sbjct: 348 SSY 350


>gi|11181770 X transporter protein 3 [Homo sapiens] >gi|8980368|emb|CAB96872.1|
           (AJ289880) orphan transporter XT3 [Homo sapiens]
           >gi|9408102|emb|CAB99310.1| (AJ276207) orphan
           transporter XT3 [Homo sapiens]
           Length = 592
           
 Score = 73.0 bits (176), Expect = 8e-12
 Identities = 71/308 (23%), Positives = 123/308 (39%), Gaps = 52/308 (16%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R  WA  +  + A    A+GLGN  RFP      GGG+F+VPY + L + G+P++++E  
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            G+   +   G++G      A  ++ P  + +     G  +   +  L+ YY  +  W+ 
Sbjct: 65  VGQ---RMRQGSIG------AWRTISPYLSGV-----GVASVVVSFFLSMYYNVINAWAF 110

Query: 131 AYSWFSI--------------------------SGAYFNVESTAKFFESYLSNHGLVFLF 164
            Y + S                           S  YF    T     S   N G+    
Sbjct: 111 WYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQ--- 167

Query: 165 W--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIK 222
           W   + ++L  + V   + +G E   KV+     +   +L+IY+       G        
Sbjct: 168 WEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIR-----GLTLHGATN 222

Query: 223 GFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATV 282
           G  ++++P    L        + A+ QIFF+L LG G +  +ASY  P ++     +   
Sbjct: 223 GLMYMFTPKIEQLANP--KAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 280

Query: 283 SLNEFAEV 290
            +N F  +
Sbjct: 281 LINSFTSI 288


>gi|6756031 X transporter protein 3 [Mus musculus] >gi|3347920|gb|AAC27756.1|
           (AF075261) orphan transporter [Mus musculus]
           Length = 635
           
 Score = 71.0 bits (171), Expect = 3e-11
 Identities = 77/311 (24%), Positives = 126/311 (39%), Gaps = 55/311 (17%)

Query: 4   GVIQMEQRDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIP 63
           GV++ + R KW   +  +L     A+GLGN  RFP      GGG+F+VPY + L + G+P
Sbjct: 42  GVVE-KVRPKWDNPLQFLLVCISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMP 100

Query: 64  VMWVEWVQGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYL 123
           ++++E   G+   +   G++G      A  ++ P       L G  +A    + L S Y 
Sbjct: 101 LLYLELAVGQ---RMRXGSIG------AWRTISPY------LSGVGIASLVVSFLASVYF 145

Query: 124 HLIG-WSAAYSWFSI--------------------------SGAYFNVESTAKFFESYLS 156
           ++I  W+  Y + S                           S  YF    T     S   
Sbjct: 146 NVINTWALWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQE 205

Query: 157 NHGLVFLFW--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLG 214
           N G+    W   + + L  + V   + +G E   KV+     +   +L+IY+       G
Sbjct: 206 NGGVQ---WEPALCLTLAWLMVYLCILRGTESTGKVVYFTTSLPYFVLIIYLVR-----G 257

Query: 215 QPQWSTIKGFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDV 274
                   G  ++++P    L        + A+ QIFF+L LG G +  +ASY  P +D 
Sbjct: 258 LTLHGATNGLAYMFTPKIEQLANP--KAWINAATQIFFSLGLGCGGLIAFASYNEPSNDC 315

Query: 275 ALSGLATVSLN 285
               L    +N
Sbjct: 316 QKHALIVSVIN 326


>pir||S50998 transporter protein (clone rB21a) - rat >gi|914028|gb|AAB32806.1|
           (S76742) neurotransmitter transporter rB21a [rats,
           brain, Peptide, 616 aa] [Rattus sp.]
           Length = 616
           
 Score = 69.9 bits (168), Expect = 7e-11
 Identities = 73/313 (23%), Positives = 124/313 (39%), Gaps = 56/313 (17%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R +W   +  + A    A+GLGN  RFP      GGG+F+VPY + L + G+P++++E  
Sbjct: 29  RPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEGMPLLYLELA 88

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            G+   +   G++G      A  ++ P  + +     G  +   +  L+ YY  +  W  
Sbjct: 89  VGQ---RMRQGSIG------AWRTISPYLSGV-----GVASVVVSFFLSMYYNVINAWGF 134

Query: 131 AYSWFSI--------------------------SGAYFNVESTAKFFESYLSNHGLVFLF 164
            Y + S                           S  YF    T     S   N G+    
Sbjct: 135 WYLFHSFQDPLPWSVCPLNSNRTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQ--- 191

Query: 165 W--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIK 222
           W   + + L  + V   + +G E   KV+     +   +L+IY+       G        
Sbjct: 192 WEPALCLTLAWLMVYLCILRGTESTGKVVYFTALMPYCVLIIYLVR-----GLTLHGATN 246

Query: 223 GFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDD----VALSG 278
           G  ++++P    L        + A+ QIFF+L LG G +  +ASY  P +D      +  
Sbjct: 247 GLMYMFTPKIEQLANP--KAWINAATQIFFSLGLGFGSLIAFASYNEPSNDCQKHAVIVS 304

Query: 279 LATVSLNEFAEVV 291
           +   S + FA +V
Sbjct: 305 VINSSTSIFASIV 317


>gb|AAC27755.1| (AF075260) orphan transporter [Homo sapiens]
           Length = 315
           
 Score = 69.5 bits (167), Expect = 9e-11
 Identities = 70/308 (22%), Positives = 122/308 (38%), Gaps = 52/308 (16%)

Query: 11  RDKWATKIGLILAMAGNAIGLGNFVRFPTQVAGNGGGAFMVPYFLALFLLGIPVMWVEWV 70
           R  WA  +  + A    A+GLGN  R P      GGG+F+VPY + L + G+P++++E  
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRNPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 71  QGRYGGKYGHGTLGPTFYLMARESLKPRSALIFGLIGGALAFATTTLLNSYYLHLIGWSA 130
            G+   +   G++G      A  ++ P  + +     G  +   +  L+ YY  +  W+ 
Sbjct: 65  VGQ---RMRQGSIG------AWRTISPYLSGV-----GVASVVVSFFLSMYYNVINAWAF 110

Query: 131 AYSWFSI--------------------------SGAYFNVESTAKFFESYLSNHGLVFLF 164
            Y + S                           S  YF    T     S   N G+    
Sbjct: 111 WYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQ--- 167

Query: 165 W--GITVVLLAIAVGQGVSKGIERWVKVMMPLLYVFAVILVIYVFALGSPLGQPQWSTIK 222
           W   + ++L  + V   + +G E   KV+     +   +L+IY+       G        
Sbjct: 168 WEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIR-----GLTVHGATN 222

Query: 223 GFEFIWSPNWTYLKEHLWSVMLAASGQIFFTLSLGMGIIQNYASYLGPKDDVALSGLATV 282
           G  ++++P    L        + A+ QIFF+L LG G +  +ASY  P ++     +   
Sbjct: 223 GLMYMFTPKIEQLANP--KAWINAATQIFFSLXLGFGSLIAFASYNEPSNNCQKHAIIVS 280

Query: 283 SLNEFAEV 290
            +N F  +
Sbjct: 281 LINSFTSI 288


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.326    0.143    0.454 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 209026083
Number of Sequences: 2977
Number of extensions: 9456337
Number of successful extensions: 30940
Number of sequences better than 1.0e-10: 119
Number of HSP's better than  0.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 30539
Number of HSP's gapped (non-prelim): 168
length of query: 527
length of database: 189,106,746
effective HSP length: 50
effective length of query: 477
effective length of database: 159,182,396
effective search space: 75930002892
effective search space used: 75930002892
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.6 bits)
S2: 167 (69.5 bits)