BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB1877 (rad2) DE:DNA repair protein RAD2 (rad2)
         (343 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||E75117 DNA repair protein rad2 (rad2) PAB1877 - Pyrococcus ...   685  0.0
pir||A71015 probable 5' nuclease - Pyrococcus horikoshii >gi|325...   651  0.0
pir||T46893 endo/exonuclease fen-1 [imported] - Pyrococcus furio...   627  e-179
gi|11497880 DNA repair protein RAD2 (rad2) [Archaeoglobus fulgid...   403  e-111
pir||H72765 probable flap endonuclease-1 APE0115 - Aeropyrum per...   400  e-110
pir||C64480 DNA repair protein RAD2 homolog - Methanococcus jann...   344  7e-94
gb|AAK40525.1| DNA repair endo/exonuclease FEN-1 (RAD2) (rad2) [...   335  3e-91
pir||C69085 DNA repair protein Rad2 - Methanobacterium thermoaut...   335  6e-91
emb|CAC12164.1| (AL445066) DNA repair protein RAD2 related prote...   303  1e-81
gb|AAB88707.1| (AF036327) flap endonuclease 1 [Xenopus laevis]        266  3e-70
gb|AAB06176.1| (U64563) 5' nuclease xFEN1a [Xenopus laevis] >gi|...   266  3e-70
gi|4758356 flap structure-specific endonuclease 1; RAD2 (S. pomb...   265  7e-70
gb|AAF60653.1| (AC024791) contains similarity to Pfam families P...   264  1e-69
gb|AAF81265.1|AF281018_1 (AF281018) flag structure-specific endo...   264  1e-69
gb|AAB08478.1| (U68141) XFEN1b [Xenopus laevis]                       262  5e-69
pir||T13692 hypothetical protein EG0003.3 - fruit fly (Drosophil...   260  1e-68
gi|6322736 42 kDa 5' to 3' exonuclease required for Okazaki frag...   249  3e-65
gi|6679771 flap structure specific endonuclease 1 [Mus musculus]...   249  5e-65
sp|P39750|RAD2_SCHPO DNA REPAIR PROTEIN RAD2 >gi|1362231|pir||A5...   248  6e-65
dbj|BAA36171.1| (AB021666) FEN-1 [Oryza sativa]                       245  5e-64
emb|CAB62862.1| (AL035475) putative flap exonuclease [Plasmodium...   227  2e-58
gb|AAG01445.1| (AF278764) flap endonuclease-1 [Plasmodium falcip...   227  2e-58
pir||T01198 endonuclease homolog F21E10.3 - Arabidopsis thaliana...   197  1e-49
gb|AAG19690.1| (AE005056) DNA repair protein; Rad2 [Halobacteriu...   164  1e-39
gb|AAD46833.1|AF160893_1 (AF160893) BcDNA.GM10765 [Drosophila me...    94  2e-18
gb|AAF50805.1| (AE003567) BcDNA:GM10765 gene product [Drosophila...    94  2e-18
gb|AAC33874.1| (AF060479) exonuclease I [Homo sapiens]                 89  6e-17
gi|11426418 exonuclease 1 [Homo sapiens] >gi|3822433|gb|AAC69879...    89  6e-17
gi|10835226 exonuclease 1; rad2 nuclease family member, homolog ...    89  6e-17
gi|11426420 Rad2 nuclease family member, homolog of S. cerevisia...    89  6e-17
gi|6753788 exonuclease 1 [Mus musculus] >gi|5689874|emb|CAB51863...    89  6e-17
gi|4504369 exonuclease 1; rad2 nuclease family member, homolog o...    89  6e-17
gb|AAF76467.1|AC020622_1 (AC020622) Contains similarity to excis...    84  2e-15
pir||E71619 RAD2 endonuclease PFB0265c - malaria parasite (Plasm...    80  3e-14
gb|AAD31867.1|AF134570_1 (AF134570) exonuclease ExoI [Xenopus la...    79  6e-14
sp|P28706|RA13_SCHPO DNA REPAIR PROTEIN RAD13 >gi|422055|pir||S3...    77  3e-13
gb|AAG12649.1|AC068667_30 (AC068667) exonuclease, putative; 9201...    76  5e-13
gi|6320469 involved in DNA repair; Din7p [Saccharomyces cerevisi...    76  7e-13
pir||T40382 dna repair protein rad13 - fission yeast  (Schizosac...    75  1e-12
sp|P53695|EXO1_SCHPO EXONUCLEASE I (EXO I) >gi|7490548|pir||T400...    74  3e-12
gi|6321697 homolog of xeroderma pigmentosum group G (XPG) protei...    73  6e-12
gi|6324607 exonuclease; Dhs1p [Saccharomyces cerevisiae] >gi|170...    73  6e-12
gb|AAD38375.1|AF144092_1 (AF144092) nucleotide excision repair p...    71  1e-11
gb|AAD50779.1|AF162792_1 (AF162792) XPG [Drosophila melanogaster]      71  1e-11
gb|AAD50780.1|AF162793_1 (AF162793) XPG variant [Drosophila mela...    71  1e-11
gb|AAG22424.1| (AE003621) mus201 gene product [alt 1] [Drosophil...    71  1e-11
gi|4503601 XPG-complementing protein; excision repair cross-comp...    71  2e-11
pir||A54439 excision repair protein ERCC5 - human >gi|306742|gb|...    71  2e-11
gb|AAF89179.1| (AF255442) xeroderma pigmentosum complementation ...    71  2e-11
gb|AAD47568.1|AF125578_1 (AF125578) DNA repair endonuclease [Dro...    70  3e-11
pir||T22235 hypothetical protein F45G2.3 - Caenorhabditis elegan...    70  3e-11
emb|CAA61430.1| (X89021) Tosca [Drosophila melanogaster]               69  9e-11
emb|CAA61431.1| (X89022) Tosca [Drosophila melanogaster] >gi|729...    69  9e-11

>pir||E75117 DNA repair protein rad2 (rad2) PAB1877 - Pyrococcus abyssi  (strain
           Orsay) >gi|5458165|emb|CAB49654.1| (AJ248285) DNA repair
           protein RAD2 (rad2) [Pyrococcus abyssi]
           Length = 343
           
 Score =  685 bits (1748), Expect = 0.0
 Identities = 343/343 (100%), Positives = 343/343 (100%)

Query: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
           MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG
Sbjct: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60

Query: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
           LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY
Sbjct: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120

Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
           AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG
Sbjct: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180

Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
           TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG
Sbjct: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240

Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300
           GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI
Sbjct: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP 343
           IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP
Sbjct: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP 343


>pir||A71015 probable 5' nuclease - Pyrococcus horikoshii
           >gi|3257838|dbj|BAA30521.1| (AP000006) 343aa long
           hypothetical 5' nuclease [Pyrococcus horikoshii]
           Length = 343
           
 Score =  651 bits (1660), Expect = 0.0
 Identities = 314/343 (91%), Positives = 337/343 (97%)

Query: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
           MGVPIG+L+PRKEI+LENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG
Sbjct: 1   MGVPIGDLVPRKEIDLENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60

Query: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
           LFYRTINLMEAGIKP YVFDGKPP FK+KELEKRREAREEAE+KWKEALAKG++EEARKY
Sbjct: 61  LFYRTINLMEAGIKPAYVFDGKPPEFKRKELEKRREAREEAELKWKEALAKGNLEEARKY 120

Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
           AQRATKVNEMLIEDAKKLLQLMGIPI+QAPSEGEAQAAYMA KGDVYASASQDYDSLLFG
Sbjct: 121 AQRATKVNEMLIEDAKKLLQLMGIPIIQAPSEGEAQAAYMASKGDVYASASQDYDSLLFG 180

Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
            PRL+RNLTITGKRKMPGKD+YVEIKPEL+VL+EVLKELKITREKLIELAILVGTDYNPG
Sbjct: 181 APRLIRNLTITGKRKMPGKDVYVEIKPELVVLDEVLKELKITREKLIELAILVGTDYNPG 240

Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300
           G+KGIGPKKALEIV+YS+DPLAKFQRQSDVDLYAIKEFFLNPP T++YSL WKEPDEEGI
Sbjct: 241 GVKGIGPKKALEIVRYSRDPLAKFQRQSDVDLYAIKEFFLNPPVTNEYSLSWKEPDEEGI 300

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP 343
           ++FLCDEH+FSEERVKNG+ERLKKAIKAG+QSTLESWF+KKKP
Sbjct: 301 LKFLCDEHNFSEERVKNGIERLKKAIKAGRQSTLESWFVKKKP 343


>pir||T46893 endo/exonuclease fen-1 [imported] - Pyrococcus furiosus
           >gi|6980604|pdb|1B43|A Chain A, Fen-1 From P. Furiosus
           >gi|6980605|pdb|1B43|B Chain B, Fen-1 From P. Furiosus
           >gi|4102602|gb|AAD01514.1| (AF013497) endo/exonuclease;
           FEN-1 [Pyrococcus furiosus]
           Length = 340
           
 Score =  627 bits (1599), Expect = e-179
 Identities = 307/338 (90%), Positives = 329/338 (96%)

Query: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
           MGVPIGE+IPRKEIELENLYGKKIAIDALNAIYQFLSTIRQ+DGTPLMDSKGRITSHLSG
Sbjct: 1   MGVPIGEIIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQKDGTPLMDSKGRITSHLSG 60

Query: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
           LFYRTINLMEAGIKPVYVFDG+PP FKKKELEKRREAREEAE KW+EAL KG+IEEARKY
Sbjct: 61  LFYRTINLMEAGIKPVYVFDGEPPEFKKKELEKRREAREEAEEKWREALEKGEIEEARKY 120

Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
           AQRAT+VNEMLIEDAKKLL+LMGIPIVQAPSEGEAQAAYMA KG VYASASQDYDSLLFG
Sbjct: 121 AQRATRVNEMLIEDAKKLLELMGIPIVQAPSEGEAQAAYMAAKGSVYASASQDYDSLLFG 180

Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
            PRLVRNLTITGKRK+PGK++YVEIKPELI+LEEVLKELK+TREKLIELAILVGTDYNPG
Sbjct: 181 APRLVRNLTITGKRKLPGKNVYVEIKPELIILEEVLKELKLTREKLIELAILVGTDYNPG 240

Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300
           GIKGIG KKALEIV++SKDPLAKFQ+QSDVDLYAIKEFFLNPP TD+Y+L W++PDEEGI
Sbjct: 241 GIKGIGLKKALEIVRHSKDPLAKFQKQSDVDLYAIKEFFLNPPVTDNYNLVWRDPDEEGI 300

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           ++FLCDEHDFSEERVKNGLERLKKAIK+GKQSTLESWF
Sbjct: 301 LKFLCDEHDFSEERVKNGLERLKKAIKSGKQSTLESWF 338


>gi|11497880 DNA repair protein RAD2 (rad2) [Archaeoglobus fulgidus]
           >gi|7446865|pir||H69282 DNA repair protein RAD2 (rad2)
           homolog - Archaeoglobus fulgidus
           >gi|2650376|gb|AAB90967.1| (AE001087) DNA repair protein
           RAD2 (rad2) [Archaeoglobus fulgidus]
           Length = 336
           
 Score =  403 bits (1025), Expect = e-111
 Identities = 204/340 (60%), Positives = 261/340 (76%), Gaps = 6/340 (1%)

Query: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
           MG  IG+L  R+E+ELE   GKKIA+DA N +YQF+S IRQ DGTPL DS+GRITSHLSG
Sbjct: 1   MGADIGDLFEREEVELEYFSGKKIAVDAFNTLYQFISIIRQPDGTPLKDSQGRITSHLSG 60

Query: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
           + YR  N++E GI+PV+VFDG+PP FKK E+E+R++ R EAE  W  AL  GD ++A+KY
Sbjct: 61  ILYRVSNMVEVGIRPVFVFDGEPPEFKKAEIEERKKRRAEAEEMWIAALQAGD-KDAKKY 119

Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
           AQ A +V+E +++ AK LL  MGIP V APSEGEAQAAYMA KGDV  + SQDYDSLLFG
Sbjct: 120 AQAAGRVDEYIVDSAKTLLSYMGIPFVDAPSEGEAQAAYMAAKGDVEYTGSQDYDSLLFG 179

Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
           +PRL RNL ITGKRK+PGK++YV++KPE+I+LE  LK L +TRE+LI++AILVGTDYN  
Sbjct: 180 SPRLARNLAITGKRKLPGKNVYVDVKPEIIILESNLKRLGLTREQLIDIAILVGTDYNE- 238

Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQR-QSDVD-LYAIKEFFLNPPTTDDYSLKWKEPDEE 298
           G+KG+G KKAL  +K   D     +  + ++D +  I+ FFLNPP TDDY ++++EPD E
Sbjct: 239 GVKGVGVKKALNYIKTYGDIFRALKALKVNIDHVEEIRNFFLNPPVTDDYRIEFREPDFE 298

Query: 299 GIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
             I FLC+EHDFS ERV+  LE+L KA+K+  Q+TLE WF
Sbjct: 299 KAIEFLCEEHDFSRERVEKALEKL-KALKS-TQATLERWF 336


>pir||H72765 probable flap endonuclease-1 APE0115 - Aeropyrum pernix  (strain
           K1) >gi|5103505|dbj|BAA79026.1| (AP000058) 401aa long
           hypothetical flap endonuclease-1 [Aeropyrum pernix]
           Length = 401
           
 Score =  400 bits (1017), Expect = e-110
 Identities = 201/349 (57%), Positives = 264/349 (75%), Gaps = 11/349 (3%)

Query: 1   MGVPIGELIP---RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSH 57
           +GV + ELIP   R+E+EL  L G  +A+DA N +YQFL+ IRQ DGTPL+D +GR+TSH
Sbjct: 52  LGVNLRELIPPEARREVELRALSGYVLALDAYNMLYQFLTAIRQPDGTPLLDREGRVTSH 111

Query: 58  LSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEA 117
           LSGLFYRTINL+E GIKPVYVFDGKPP  K +E+E+R   + EAE +++ A+  G++EEA
Sbjct: 112 LSGLFYRTINLVEEGIKPVYVFDGKPPEMKSREVEERLRRKAEAEARYRRAVEAGEVEEA 171

Query: 118 RKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSL 177
           RKYA  A ++   ++E++K+LL  MG+P VQAP+EGEAQAAYMA KGD +A+ SQDYDSL
Sbjct: 172 RKYAMMAARLTSDMVEESKELLDAMGMPWVQAPAEGEAQAAYMARKGDAWATGSQDYDSL 231

Query: 178 LFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDY 237
           LFG+PRLVRNL ITG+RK+PG+D YVEIKPE+I LE +L +L ITRE+LI + IL+GTDY
Sbjct: 232 LFGSPRLVRNLAITGRRKLPGRDQYVEIKPEIIELEPLLSKLGITREQLIAVGILLGTDY 291

Query: 238 NPGGIKGIGPKKALEIVKYSKDP---LAKFQR-QSDVD-LYAIKEFFLNPPTTDDYSLKW 292
           NPGG++G GPK AL +VK   DP   LA   R + D D L  + E+FLNPP TDDY +++
Sbjct: 292 NPGGVRGYGPKTALRLVKSLGDPMKVLASVPRGEYDPDYLRKVYEYFLNPPVTDDYKIEF 351

Query: 293 KEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIK---AGKQSTLESWF 338
           ++PD++ +   L + HDF+ ERV+  LERL KA +    G+QS L+ WF
Sbjct: 352 RKPDQDKVREILVERHDFNPERVERALERLGKAYREKLRGRQSRLDMWF 400


>pir||C64480 DNA repair protein RAD2 homolog - Methanococcus jannaschii
           >gi|5821777|pdb|1A76|  Flap Endonuclease-1 From
           Methanococcus Jannaschii >gi|5821778|pdb|1A77|  Flap
           Endonuclease-1 From Methanococcus Jannaschii
           >gi|1592090|gb|AAB99454.1| (U67585) DNA repair protein
           RAD2 (rad2) [Methanococcus jannaschii]
           Length = 326
           
 Score =  344 bits (874), Expect = 7e-94
 Identities = 179/340 (52%), Positives = 243/340 (70%), Gaps = 17/340 (5%)

Query: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
           MGV  G+ IP+  I  E+L GKK+AID +NA+YQFL++IR RDG+PL + KG ITS  +G
Sbjct: 1   MGVQFGDFIPKNIISFEDLKGKKVAIDGMNALYQFLTSIRLRDGSPLRNRKGEITSAYNG 60

Query: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
           +FY+TI+L+E  I P++VFDG+PP  K+K  + RRE +E+AE+K KEA+ K D EEA KY
Sbjct: 61  VFYKTIHLLENDITPIWVFDGEPPKLKEKTRKVRREMKEKAELKMKEAIKKEDFEEAAKY 120

Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
           A+R + +   ++E+ K LL LMGIP V+APSEGEAQA+YMA KGDV+A  SQDYD+LL+G
Sbjct: 121 AKRVSYLTPKMVENCKYLLSLMGIPYVEAPSEGEAQASYMAKKGDVWAVVSQDYDALLYG 180

Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
            PR+VRNLT T +             PELI L EVL++L+I+ + LI++AI +GTDYNPG
Sbjct: 181 APRVVRNLTTTKE------------MPELIELNEVLEDLRISLDDLIDIAIFMGTDYNPG 228

Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLY-AIKEFFLNPPTTDDYSLKWKEPDEEG 299
           G+KGIG K+A E+V   +  +AK   + +V+ Y  IK  F  P  TD+YSL  K PD+EG
Sbjct: 229 GVKGIGFKRAYELV---RSGVAKDVLKKEVEYYDEIKRIFKEPKVTDNYSLSLKLPDKEG 285

Query: 300 IIRFLCDEHDFSEERVKNGLERLKKAI-KAGKQSTLESWF 338
           II+FL DE+DF+ +RVK  +++L   I    KQ TL++WF
Sbjct: 286 IIKFLVDENDFNYDRVKKHVDKLYNLIANKTKQKTLDAWF 325


>gb|AAK40525.1| DNA repair endo/exonuclease FEN-1 (RAD2) (rad2) [Sulfolobus
           solfataricus]
           Length = 302
           
 Score =  335 bits (851), Expect = 3e-91
 Identities = 174/302 (57%), Positives = 230/302 (75%), Gaps = 11/302 (3%)

Query: 48  MDSKGRITSHLSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKE 107
           MDS+GR+TSHLSGLFYRTIN++E G+ P+YVFDGKPP  K +ELE+RR+A+EEAE K + 
Sbjct: 1   MDSQGRVTSHLSGLFYRTINILEEGVIPIYVFDGKPPEQKSEELERRRKAKEEAERKLER 60

Query: 108 ALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVY 167
           A ++G IEE RKY+Q   +++ +++E++KKLL+ MGIPIVQAPSEGEA+AAY+   G  +
Sbjct: 61  AKSEGKIEELRKYSQAILRLSNIMVEESKKLLRAMGIPIVQAPSEGEAEAAYLNKLGLSW 120

Query: 168 ASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLI 227
           A+ASQDYD++LFG  RLVRNLTITGKRK+P KD+YVEIKPELI  E +LK+L ITRE+LI
Sbjct: 121 AAASQDYDAILFGAKRLVRNLTITGKRKLPNKDVYVEIKPELIETEILLKKLGITREQLI 180

Query: 228 ELAILVGTDYNPGGIKGIGPKKALEIV-KYSKDPLAK-----FQRQSDVDLYAIKEFFLN 281
           ++ IL+GTDYNP GI+GIGP++AL+I+ KY K   A       ++  + ++  I+  FLN
Sbjct: 181 DIGILIGTDYNPDGIRGIGPERALKIIKKYGKIEKAMEYGEISKKDINFNIDEIRGLFLN 240

Query: 282 PPTT-DDYSLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIK----AGKQSTLES 336
           P     + +L   EP+ E II  L  EH+FSEERVKNG+ERL KAIK    A +Q+ L+ 
Sbjct: 241 PQVVKPEEALDLNEPNGEDIINILVYEHNFSEERVKNGIERLTKAIKEAKGASRQTGLDR 300

Query: 337 WF 338
           WF
Sbjct: 301 WF 302


>pir||C69085 DNA repair protein Rad2 - Methanobacterium thermoautotrophicum
           (strain Delta H) >gi|2622760|gb|AAB86106.1| (AE000922)
           DNA repair protein Rad2 [Methanobacterium
           thermoautotrophicum]
           Length = 328
           
 Score =  335 bits (849), Expect = 6e-91
 Identities = 161/342 (47%), Positives = 243/342 (70%), Gaps = 18/342 (5%)

Query: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
           MGV + +++  + I LE+L G+ +A+DA N +YQFLS+IRQRDGTPLMDS+GR+TSHLSG
Sbjct: 1   MGVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSG 60

Query: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
           + YRT  +ME  I+ +YVFDG+    K + + +R + R+++E++WK AL +GDI+ A+KY
Sbjct: 61  ILYRTAAVMEREIRVIYVFDGRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKY 120

Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
           A R+++++  ++E +K+LL+L+GIP VQAP EGEAQA+YM   GD +A ASQDYD LLFG
Sbjct: 121 AVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYMVKMGDAWAVASQDYDCLLFG 180

Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
            PR+VRNLT++GK +           PE+I LE  L+EL I+  +L+++A+LVGTD+N  
Sbjct: 181 APRVVRNLTLSGKLE----------DPEIIELESTLRELSISHTQLVDMALLVGTDFNE- 229

Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDL----YAIKEFFLNPPTTDDYSLKWKEPD 296
           G+KGIG ++ L++++  K  + K  R  + D+      ++  FL P  ++DY ++W++PD
Sbjct: 230 GVKGIGARRGLKLIR-EKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPD 288

Query: 297 EEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
            EG+I FLC EH FSE+RV+  L++ + A  +  Q +LE WF
Sbjct: 289 VEGVIEFLCTEHGFSEDRVRAALKKFEGA--SSTQKSLEDWF 328


>emb|CAC12164.1| (AL445066) DNA repair protein RAD2 related protein [Thermoplasma
           acidophilum]
           Length = 336
           
 Score =  303 bits (769), Expect = 1e-81
 Identities = 160/339 (47%), Positives = 226/339 (66%), Gaps = 6/339 (1%)

Query: 1   MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
           MG  I +++   E  L++   +  +ID  N +YQ LS +RQ DG PLMDS G +TSHL G
Sbjct: 1   MGTDISDIVVSHETSLKDQGNQTFSIDTYNILYQLLSNVRQYDGMPLMDSHGNVTSHLYG 60

Query: 61  LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
           +FYRTINL+E  I+PVYVFDGKP   K + + +R+  +E+A+ + +EA+ +G+ E+ R+Y
Sbjct: 61  IFYRTINLLENRIRPVYVFDGKPSPLKNRTISERQMMKEKAKAELEEAIERGE-EDLRQY 119

Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
             R   +   +++D KKLL  MGIP V APSEGEAQA+YM  K +V    SQDYD LLFG
Sbjct: 120 YSRINYITPQIVDDTKKLLDYMGIPYVDAPSEGEAQASYMT-KKNVDGVISQDYDCLLFG 178

Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
             +++RN  I G+RK+P K+IY  + PE I+L+EVL   +I +++LI + ILVGTD+N  
Sbjct: 179 ARKILRNFAIYGRRKVPRKNIYKTVYPEYIILDEVLSANQINQDQLIGIGILVGTDFNE- 237

Query: 241 GIKGIGPKKALEIVKYSKD--PLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEE 298
           GIKGIG KKAL ++K   D   + K   ++  +L  I +FF NPP   DY  K+++PD +
Sbjct: 238 GIKGIGAKKALALIKKEGDIKSVLKHIGKNIENLDEIIDFFKNPPVV-DYDFKFRKPDTD 296

Query: 299 GIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESW 337
            I  FLCDEHDFS ER+++ LE L+K  +A  Q  L+S+
Sbjct: 297 AIEHFLCDEHDFSRERIRDHLESLRKNDQASTQFRLDSF 335


>gb|AAB88707.1| (AF036327) flap endonuclease 1 [Xenopus laevis]
           Length = 382
           
 Score =  266 bits (673), Expect = 3e-70
 Identities = 145/338 (42%), Positives = 209/338 (60%), Gaps = 23/338 (6%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           KE ++++ +G+K+AIDA   IYQFL  +RQ DG  L + +G  TSHL G+FYRTI ++E 
Sbjct: 19  KEHDIKSYFGRKVAIDASMCIYQFLIAVRQ-DGNTLQNEEGETTSHLMGMFYRTIRMVEH 77

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKPVYVFDGKPP  K  EL KR E R EAE   + A   G++E   K+ +R  KV +  
Sbjct: 78  GIKPVYVFDGKPPQMKSGELAKRSERRAEAEKLLEAAEEAGEVENIEKFTKRLVKVTKQH 137

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            E+ KKLL LMGIP V AP E EA  A +   G VYA+A++D D+L FGTP L+R+LT +
Sbjct: 138 NEECKKLLTLMGIPYVDAPCEAEATCAALVKAGKVYAAATEDMDALTFGTPVLLRHLTAS 197

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
             +K+P ++ +         L  V++++ IT E+ ++L IL+G+DY    I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LNRVIQDIGITHEQFVDLCILLGSDYCE-TIRGIGPKRAI 247

Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPT--TDDYSLKWKEPDEEGI 300
           ++++  K  + +     D+  Y +         K  FL P    TD   LKW EPDEEG+
Sbjct: 248 DLIRQHK-TIDEIIDNIDLKKYPVPENWLHKEAKHLFLEPEVVDTDITELKWIEPDEEGL 306

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           + F+C E  FSE+R++NG ++L K  +   Q  L+ +F
Sbjct: 307 VAFMCGEKQFSEDRIRNGAKKLAKNRQGSTQGRLDDFF 344


>gb|AAB06176.1| (U64563) 5' nuclease xFEN1a [Xenopus laevis]
           >gi|4106358|gb|AAD02814.1| (AF065397) flap endonuclease
           1 [Xenopus laevis]
           Length = 382
           
 Score =  266 bits (672), Expect = 3e-70
 Identities = 144/338 (42%), Positives = 209/338 (61%), Gaps = 23/338 (6%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           KE ++++ +G+K+A+DA   IYQFL  +RQ DG  L + +G  TSHL G+FYRTI ++E 
Sbjct: 19  KEHDIKSYFGRKVAVDASMCIYQFLIAVRQ-DGNTLQNEEGETTSHLMGMFYRTIRMVEH 77

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKPVYVFDGKPP  K  EL KR E R EAE   + A   G++E   K+ +R  KV +  
Sbjct: 78  GIKPVYVFDGKPPQMKSGELAKRSERRAEAEKLLEAAEEAGEVENIEKFTKRLVKVTKQH 137

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            E+ KKLL LMGIP V AP E EA  A +   G VYA+A++D D+L FGTP L+R+LT +
Sbjct: 138 NEECKKLLTLMGIPYVDAPCEAEATCAALVKAGKVYAAATEDMDALTFGTPVLLRHLTAS 197

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
             +K+P ++ +         L  V++++ IT E+ ++L IL+G+DY    I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LNRVIQDIGITHEQFVDLCILLGSDYCE-TIRGIGPKRAI 247

Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPT--TDDYSLKWKEPDEEGI 300
           ++++  K  + +     D+  Y +         K  FL P    TD   LKW EPDEEG+
Sbjct: 248 DLIRQHK-TIDEIIDNIDLKKYPVPENWLHKEAKHLFLEPEVVDTDITELKWIEPDEEGL 306

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           + F+C E  FSE+R++NG ++L K  +   Q  L+ +F
Sbjct: 307 VAFMCGEKQFSEDRIRNGAKKLAKNRQGSTQGRLDDFF 344


>gi|4758356 flap structure-specific endonuclease 1; RAD2 (S. pombe) homolog
           [Homo sapiens] >gi|11439793|ref|XP_006414.1| flap
           structure-specific endonuclease 1 [Homo sapiens]
           >gi|729475|sp|P39748|FEN1_HUMAN FLAP ENDONUCLEASE-1
           (MATURATION FACTOR 1) (MF1) >gi|1362788|pir||A56531 DNA
           structure-specific endonuclease FEN1 [validated] - human
           >gi|642090|gb|AAA91331.1| (L37374) endonuclease [Homo
           sapiens] >gi|704377|gb|AAB32522.1| DNase IV=nuclear 42
           kda 5' -> 3' exonuclease [human, HeLa cells, Peptide,
           380 aa] >gi|3169155|gb|AAC23394.1| (AC004770)
           FEN1_HUMAN; MATURATION FACTOR 1 (MF1); DNase IV;
           RAD2_HUMAN [Homo sapiens] >gi|3980293|emb|CAA54166.1|
           (X76771) flap endonuclease-1 [Homo sapiens]
           Length = 380
           
 Score =  265 bits (669), Expect = 7e-70
 Identities = 143/338 (42%), Positives = 214/338 (63%), Gaps = 23/338 (6%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           +E ++++ +G+K+AIDA  +IYQFL  +RQ  G  L + +G  TSHL G+FYRTI +ME 
Sbjct: 19  RENDIKSYFGRKVAIDASMSIYQFLIAVRQ-GGDVLQNEEGETTSHLMGMFYRTIRMMEN 77

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKPVYVFDGKPP  K  EL KR E R EAE + ++A A G  +E  K+ +R  KV +  
Sbjct: 78  GIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQH 137

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            ++ K LL LMGIP + APSE EA  A +   G VYA+A++D D L FG+P L+R+LT +
Sbjct: 138 NDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTAS 197

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
             +K+P ++ +         L  +L+EL + +E+ ++L IL+G+DY    I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LSRILQELGLNQEQFVDLCILLGSDYCE-SIRGIGPKRAV 247

Query: 252 EIVKYSKDPLAKFQRQSDVDLYAIKE---------FFLNPPTTDDYS--LKWKEPDEEGI 300
           ++++  K  + +  R+ D + Y + E          FL P   D  S  LKW EP+EE +
Sbjct: 248 DLIQKHKS-IEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEEL 306

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           I+F+C E  FSEER+++G++RL K+ +   Q  L+ +F
Sbjct: 307 IKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFF 344


>gb|AAF60653.1| (AC024791) contains similarity to Pfam families PF00752 (XPG
           N-terminal domain, score=189.5, E=5.3e-53, N=1) and
           PF00867 (XPG I-region, score=138.6, E=1.1e-37, N=1)
           [Caenorhabditis elegans]
           Length = 382
           
 Score =  264 bits (668), Expect = 1e-69
 Identities = 141/334 (42%), Positives = 208/334 (62%), Gaps = 21/334 (6%)

Query: 15  ELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEAGIK 74
           E++  +G+ +AIDA   +YQFL  +RQ DG+ L    G  TSHL G+  RT+ + E G+K
Sbjct: 22  EMKAFFGRTVAIDASMCLYQFLIAVRQ-DGSQLQSEDGETTSHLMGMLNRTVRMFENGVK 80

Query: 75  PVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIED 134
           PVYVFDGKPP  K  ELEKR E R EAE    EA  KGD++EA K+ +R  KV +   ++
Sbjct: 81  PVYVFDGKPPDMKGGELEKRSERRAEAEKALTEAKEKGDVKEAEKFERRLVKVTKQQNDE 140

Query: 135 AKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKR 194
           AK+LL LMGIP+V+AP E EAQ A++   G V+ + ++D D+L FG+  L+R+      +
Sbjct: 141 AKRLLGLMGIPVVEAPCEAEAQCAHLVKAGKVFGTVTEDMDALTFGSTVLLRHFLAPVAK 200

Query: 195 KMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIV 254
           K+P K+  + +          L+E+K++ E+ I+L IL+G DY  G I+G+GPKKA+E++
Sbjct: 201 KIPIKEFNLSL---------ALEEMKLSVEEFIDLCILLGCDY-CGTIRGVGPKKAVELI 250

Query: 255 KYSKD--------PLAKFQRQSDVDLYAIKEFFLNPPTT--DDYSLKWKEPDEEGIIRFL 304
           +  K+           K+    D      +E FLNP  T  ++  L WKE D EG+I+FL
Sbjct: 251 RQHKNIETILENIDQNKYPPPEDWPYKRARELFLNPEVTKPEEVELTWKEADVEGVIQFL 310

Query: 305 CDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           C E +F+EER++N L +LK + K+G Q  ++S+F
Sbjct: 311 CGEKNFNEERIRNALAKLKTSRKSGTQGRIDSFF 344


>gb|AAF81265.1|AF281018_1 (AF281018) flag structure-specific endonuclease [Rattus norvegicus]
           Length = 380
           
 Score =  264 bits (667), Expect = 1e-69
 Identities = 140/338 (41%), Positives = 214/338 (62%), Gaps = 23/338 (6%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           +E ++++ +G+K+AIDA  +IYQFL  +RQ  G  L + +G  TSHL G+FYRTI +ME 
Sbjct: 19  RENDIKSYFGRKVAIDASMSIYQFLIAVRQ-GGDVLQNEEGETTSHLMGMFYRTIRMMEN 77

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKPVY+FDGKPP  K  +L KR E R EAE + ++A   G  EE  K+ +R  KV +  
Sbjct: 78  GIKPVYIFDGKPPQLKSAQLAKRSERRAEAEKQLQQAQEAGAEEEVEKFTKRLVKVTKQH 137

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            ++ K LL LMGIP + APSE EA  A +A  G VYA+A++D D L FG+P L+R+LT +
Sbjct: 138 NDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSPVLMRHLTAS 197

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
             +K+P ++ +         L  VL+EL + +E+ ++L IL+G+DY    ++GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LSRVLQELGLNQEQFVDLCILLGSDYCE-SVRGIGPKRAV 247

Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPTTDDYS--LKWKEPDEEGI 300
           ++++  K  + +  R+ D   Y +         ++ FL P   D  S  LKW EP+EE +
Sbjct: 248 DLIQKHKS-IEEIVRRLDPSKYPVPENWLHKEARQLFLEPEVVDPESVELKWSEPNEEEL 306

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           ++F+C E  FSEER+++G++RL K+ +   Q  L+ +F
Sbjct: 307 VKFMCGEKQFSEERIRSGVKRLNKSRQGSTQGRLDDFF 344


>gb|AAB08478.1| (U68141) XFEN1b [Xenopus laevis]
           Length = 382
           
 Score =  262 bits (662), Expect = 5e-69
 Identities = 142/338 (42%), Positives = 207/338 (61%), Gaps = 23/338 (6%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           KE ++++ +G+K+A+DA   IYQFL  +RQ DG  L + +G  TSHL G+FYRTI ++E 
Sbjct: 19  KEHDIKSYFGRKVAVDASMCIYQFLIAVRQ-DGNMLQNEEGETTSHLMGMFYRTIRMLEH 77

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKPVYVFDGKPP  K  EL KR E R EAE   + A   G++E   K+ +R  KV +  
Sbjct: 78  GIKPVYVFDGKPPQMKSGELAKRSERRAEAEKLLEAAEEAGEVENIEKFNKRLVKVTKQH 137

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            E+ KKLL LMGIP V AP E EA  A +   G VYA+A++D D+L FGTP L+R+LT +
Sbjct: 138 NEECKKLLSLMGIPYVDAPCEAEATCAALVKAGKVYAAATEDMDALTFGTPVLLRHLTAS 197

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
             +K+P ++ +         L  V +++ I  E+ ++L IL+G+DY    I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LNRVFQDIGINHEQFVDLCILLGSDYCE-TIRGIGPKRAI 247

Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPT--TDDYSLKWKEPDEEGI 300
           ++++  K  + +     D+  Y I         ++ FL P     D   LKW EPDEEG+
Sbjct: 248 DLIRQHK-TIEEIIDNIDLKKYPIPENWLHKEARQLFLEPEVIDADITELKWTEPDEEGL 306

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           + F+C E  FSE+R++NG ++L K  +   Q  L+ +F
Sbjct: 307 VAFMCGEKQFSEDRIRNGAKKLAKNRQGSTQGRLDDFF 344


>pir||T13692 hypothetical protein EG0003.3 - fruit fly (Drosophila melanogaster)
           >gi|3929699|emb|CAA21320.1| (AL031863)
           1-evidence=predicted by
           match~1-match_accession=SWISS-PROT:P39748~1-
           match_description=FLAP ENDONUCLEASE-1 (MATURATION FACTOR
           1) (MF1).~1-match_species=HOMO SAPIENS
           (HUMAN).~1-method=blastx;1.4.9~1-method_score=102.00;
           1129.00~1-evidence_end~> >gi|7302871|gb|AAF57944.1|
           (AE003805) EG:EG0003.3 gene product [Drosophila
           melanogaster]
           Length = 385
           
 Score =  260 bits (658), Expect = 1e-68
 Identities = 147/346 (42%), Positives = 210/346 (60%), Gaps = 23/346 (6%)

Query: 5   IGELIPR--KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLF 62
           I +L P+  +E E+++ +G+K+AIDA   +YQFL  +R  +G  L    G  TSHL G+F
Sbjct: 10  IADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRS-EGAQLATVNGDPTSHLMGMF 68

Query: 63  YRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQ 122
           YRTI L++ GIKPVYVFDGKPP  K  EL KR E REEAE   K A   GD     K+ +
Sbjct: 69  YRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNR 128

Query: 123 RATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTP 182
           R  +V +   ++AK+LL LMG+P V AP E EAQ A +   G VYA+A++D D+L FG+ 
Sbjct: 129 RLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGST 188

Query: 183 RLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGI 242
           +L+R LT +  RKMP K+            +++L+ L I   + I+L IL+G DY    I
Sbjct: 189 KLLRYLTYSEARKMPVKE---------FSYDKLLEGLAINNREFIDLCILLGCDYCE-SI 238

Query: 243 KGIGPKKALEIVKYSKD--------PLAKFQRQSDVDLYAIKEFFLNPPT--TDDYSLKW 292
           KGIGPK+A+E++   +D          +K+    + +    +E F+ P     D   LKW
Sbjct: 239 KGIGPKRAIELINTYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVADADSIDLKW 298

Query: 293 KEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
            EPDEEG+++FLC +  F+EERV+NG ++L K+ +A  Q  L+S+F
Sbjct: 299 VEPDEEGLVKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFF 344


>gi|6322736 42 kDa 5' to 3' exonuclease required for Okazaki fragment
           processing; Rad27p [Saccharomyces cerevisiae]
           >gi|140964|sp|P26793|RA27_YEAST STRUCTURE SPECIFIC
           ENDONUCLEASE RAD27 >gi|320768|pir||S22267 hypothetical
           protein YKL113c - yeast (Saccharomyces cerevisiae)
           >gi|248392|gb|AAB21998.1| (S93804) RAD2 homolog=YKL510
           [Saccharomyces cerevisiae, Peptide, 382 aa]
           >gi|486190|emb|CAA81953.1| (Z28113) ORF YKL113c
           [Saccharomyces cerevisiae]
           Length = 382
           
 Score =  249 bits (630), Expect = 3e-65
 Identities = 146/351 (41%), Positives = 216/351 (60%), Gaps = 30/351 (8%)

Query: 5   IGELIPR--KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLF 62
           I E +P   ++ ++++ +G+K+AIDA  ++YQFL  +RQ+DG  L +  G  TSHL G+F
Sbjct: 10  ISEHVPSAIRKSDIKSFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMF 69

Query: 63  YRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQ 122
           YRT+ +++ GIKP YVFDGKPP  K  EL KR   R E E K  EA  +    E  K  +
Sbjct: 70  YRTLRMIDNGIKPCYVFDGKPPDLKSHELTKRSSRRVETEKKLAEATTE---LEKMKQER 126

Query: 123 RATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTP 182
           R  KV++   E+A+KLL LMGIP + AP+E EAQ A +A KG VYA+AS+D D+L + TP
Sbjct: 127 RLVKVSKEHNEEAQKLLGLMGIPYIIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRTP 186

Query: 183 RLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGI 242
            L+R+LT +  +K P  +I  E+         VL+ L +T E+ ++L I++G DY    I
Sbjct: 187 FLLRHLTFSEAKKEPIHEIDTEL---------VLRGLDLTIEQFVDLCIMLGCDYCE-SI 236

Query: 243 KGIGPKKALEIVKY--SKDPLAKF--QRQSDVDLYAIKE---------FFLNPPTTD--D 287
           +G+GP  AL+++K   S + + +F    +S+   + I E          FL+P   D  +
Sbjct: 237 RGVGPVTALKLIKTHGSIEKIVEFIESGESNNTKWKIPEDWPYKQARMLFLDPEVIDGNE 296

Query: 288 YSLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
            +LKW  P E+ +I +LCD+  FSEERVK+G+ RLKK +K+G Q  L+ +F
Sbjct: 297 INLKWSPPKEKELIEYLCDDKKFSEERVKSGISRLKKGLKSGIQGRLDGFF 347


>gi|6679771 flap structure specific endonuclease 1 [Mus musculus]
           >gi|729476|sp|P39749|FEN1_MOUSE FLAP ENDONUCLEASE-1
           >gi|1083325|pir||A53730 flap endonuclease 1 - mouse
           >gi|499649|gb|AAC37664.1| (L26320) endonuclease-1 [Mus
           musculus]
           Length = 378
           
 Score =  249 bits (628), Expect = 5e-65
 Identities = 142/338 (42%), Positives = 210/338 (62%), Gaps = 25/338 (7%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           +E ++++ +G+K+AIDA  +IYQFL  +RQ  G  L + +G  TS L G+FYRTI  ME 
Sbjct: 19  RENDIKSYFGRKVAIDASMSIYQFLIAVRQ-GGDVLQNEEGETTS-LMGMFYRTIR-MEN 75

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKPVYVFDGKPP  K  EL KR E R EAE + ++A   G  EE  K+ +R  KV +  
Sbjct: 76  GIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQEAGMEEEVEKFTKRLVKVTKQH 135

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            ++ K LL LMGIP + APSE EA  A +A  G VYA+A++D D L FG+P L+R+LT +
Sbjct: 136 NDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSPVLMRHLTAS 195

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
             +K+P ++ +         L  VL+EL + +E+ ++L IL+G+DY    I+GIG K+A+
Sbjct: 196 EAKKLPIQEFH---------LSRVLQELGLNQEQFVDLCILLGSDYCE-SIRGIGAKRAV 245

Query: 252 EIVKYSKDPLAKFQRQSDVDLYAIKE---------FFLNPPTTDDYS--LKWKEPDEEGI 300
           ++++  K  + +  R+ D   Y + E          FL P   D  S  LKW EP+EE +
Sbjct: 246 DLIQKHKS-IEEIVRRLDPSKYPVPENWLHKEAQQLFLEPEVVDPESVELKWSEPNEEEL 304

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           ++F+C E  FSEER+++G++RL K+ +   Q  L+ +F
Sbjct: 305 VKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFF 342


>sp|P39750|RAD2_SCHPO DNA REPAIR PROTEIN RAD2 >gi|1362231|pir||A56054 DNA repair
           endonuclease rad2 - fission yeast  (Schizosaccharomyces
           pombe) >gi|2408077|emb|CAB16282.1| (Z99167) dna repair
           protein Rad2p [Schizosaccharomyces pombe]
           >gi|4456854|emb|CAB36991.1| (X77041) RAD2 protein
           [Schizosaccharomyces pombe]
           Length = 380
           
 Score =  248 bits (627), Expect = 6e-65
 Identities = 138/338 (40%), Positives = 205/338 (59%), Gaps = 22/338 (6%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           K  +++N +G+K+AIDA  ++YQFL  +R +DG  LM+ +G  TSHL G+FYRT+ +++ 
Sbjct: 19  KHNDIKNYFGRKVAIDASMSLYQFLIQVRSQDGQQLMNEQGETTSHLMGMFYRTLRIVDN 78

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKP +VFDGKPP  K  EL KR    ++A    +E    G  E   ++A+R  KV    
Sbjct: 79  GIKPCFVFDGKPPTLKSGELAKRVARHQKAREDQEETKEVGTAEMVDRFAKRTVKVTRQH 138

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            ++AK+LL+LMGIP V AP E EAQ A +A  G VYA+AS+D D+L F  P L+R+LT +
Sbjct: 139 NDEAKRLLELMGIPFVNAPCEAEAQCAALARSGKVYAAASEDMDTLCFQAPVLLRHLTFS 198

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
            +RK P  +  +         E+ L  L ++ E+ ++L IL+G DY    I+G+GP +A+
Sbjct: 199 EQRKEPISEYNI---------EKALNGLDMSVEQFVDLCILLGCDYCE-PIRGVGPARAV 248

Query: 252 EIVKYSKDPLAKFQRQSDVDLYAIKE---------FFLNPPTT--DDYSLKWKEPDEEGI 300
           E+++     L +F +++D   Y I E          FL+      ++  LKWK PD +GI
Sbjct: 249 ELIR-QYGTLDRFVKEADRSKYPIPEDWPYEDARRLFLDAEVLPGEEIELKWKSPDADGI 307

Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           I+FL  E  F+E+RVK G+ RL+KA K   Q  L+S+F
Sbjct: 308 IQFLVKEKGFNEDRVKLGINRLEKASKTIPQGRLDSFF 345


>dbj|BAA36171.1| (AB021666) FEN-1 [Oryza sativa]
           Length = 380
           
 Score =  245 bits (619), Expect = 5e-64
 Identities = 139/339 (41%), Positives = 202/339 (59%), Gaps = 25/339 (7%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
           KE + E+ +G++IA+DA  +IYQFL  + +     L +  G +TSHL G+F RTI L+EA
Sbjct: 19  KEQKFESYFGRRIAVDASMSIYQFLIVVGRTGMETLTNEAGEVTSHLQGMFNRTIRLLEA 78

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           GIKPVYVFDGKPP  KK+EL KR   RE+A  +  EA+ +GD +   K+++R  KV +  
Sbjct: 79  GIKPVYVFDGKPPDLKKQELAKRYSKREDATKELTEAVEEGDKDAIEKFSKRTVKVTKQH 138

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
            E+ K+LL+LMG+P+V+AP E EA+ A +     VYA AS+D DSL FG PR +R+L   
Sbjct: 139 NEECKRLLRLMGVPVVEAPCEAEAECAALCINDMVYAVASEDMDSLTFGAPRFLRHLMDP 198

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
             +K+P  +  V          +VL+EL++T ++ I+L IL G DY    IKGIG + AL
Sbjct: 199 SSKKIPVMEFEV---------AKVLEELELTMDQFIDLCILSGCDY-CDSIKGIGGQTAL 248

Query: 252 EIVK-----------YSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDY-SLKWKEPDEEG 299
           ++++            +KD   ++Q   D      +  F  P  T D   LKW  PDEEG
Sbjct: 249 KLIRQHGSIESILENINKD---RYQIPEDWPYQEARRLFKEPNVTLDIPELKWNAPDEEG 305

Query: 300 IIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
           ++ FL  E+ F+++RV   +E++K A     Q  LES+F
Sbjct: 306 LVEFLVKENGFNQDRVTKAIEKIKFAKNKSSQGRLESFF 344


>emb|CAB62862.1| (AL035475) putative flap exonuclease [Plasmodium falciparum]
           Length = 672
           
 Score =  227 bits (572), Expect = 2e-58
 Identities = 139/343 (40%), Positives = 199/343 (57%), Gaps = 20/343 (5%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTP-LMDSKGRITSHLSGLFYRTINLME 70
           KEI++E+L G+ IAIDA  ++YQF+  IR  +    L +  G  TSH+SGL  R+I LME
Sbjct: 19  KEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLME 78

Query: 71  AGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEM 130
            G+KP+YVFDG PP  K  ELEKR E R++AE   K+A  +G++EE +K + R  +V   
Sbjct: 79  NGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRK 138

Query: 131 LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTI 190
             E+AKKLL LMGIPI++AP E E+Q A++      +A+A++D D+L+FGT  L+RNL  
Sbjct: 139 QNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNA 198

Query: 191 T-----GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGI 245
                  K K   K  Y+  +   I LE+VLK L +T ++ I+  IL G DY    IKGI
Sbjct: 199 NATSNQNKNKNNSKRGYILTE---INLEQVLKGLNLTMDEFIDFCILCGCDY-CDTIKGI 254

Query: 246 GPKKALEIVK--------YSKDPLAKFQRQSDVDLYAIKEFFLNPPT--TDDYSLKWKEP 295
           G K A  ++K               K+Q  S+      ++ F+NP     +D  + W EP
Sbjct: 255 GSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEP 314

Query: 296 DEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
             E +  FL  +++F+E RV N + RL KA K   Q  L+++F
Sbjct: 315 QIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFF 357


>gb|AAG01445.1| (AF278764) flap endonuclease-1 [Plasmodium falciparum]
           Length = 650
           
 Score =  227 bits (572), Expect = 2e-58
 Identities = 139/343 (40%), Positives = 199/343 (57%), Gaps = 20/343 (5%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTP-LMDSKGRITSHLSGLFYRTINLME 70
           KEI++E+L G+ IAIDA  ++YQF+  IR  +    L +  G  TSH+SGL  R+I LME
Sbjct: 19  KEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLME 78

Query: 71  AGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEM 130
            G+KP+YVFDG PP  K  ELEKR E R++AE   K+A  +G++EE +K + R  +V   
Sbjct: 79  NGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRK 138

Query: 131 LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTI 190
             E+AKKLL LMGIPI++AP E E+Q A++      +A+A++D D+L+FGT  L+RNL  
Sbjct: 139 QNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNA 198

Query: 191 T-----GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGI 245
                  K K   K  Y+  +   I LE+VLK L +T ++ I+  IL G DY    IKGI
Sbjct: 199 NATSNQNKNKNNSKRGYILTE---INLEQVLKGLNLTMDEFIDFCILCGCDY-CDTIKGI 254

Query: 246 GPKKALEIVK--------YSKDPLAKFQRQSDVDLYAIKEFFLNPPT--TDDYSLKWKEP 295
           G K A  ++K               K+Q  S+      ++ F+NP     +D  + W EP
Sbjct: 255 GSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEP 314

Query: 296 DEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
             E +  FL  +++F+E RV N + RL KA K   Q  L+++F
Sbjct: 315 QIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFF 357


>pir||T01198 endonuclease homolog F21E10.3 - Arabidopsis thaliana
           >gi|3047083|gb|AAC13596.1| (AF058914) similar to FLAP
           endonuclease-1 (SW:P39748) [Arabidopsis thaliana]
           Length = 362
           
 Score =  197 bits (496), Expect = 1e-49
 Identities = 124/348 (35%), Positives = 184/348 (52%), Gaps = 54/348 (15%)

Query: 12  KEIELENLYGKKIAIDALNAIYQFL-----STIRQRDGTPLMDSKGRITS---------- 56
           KE + E+ +G+KIA+DA  +IYQFL     S +   +   L  S  ++            
Sbjct: 19  KEQKFESYFGRKIAVDASMSIYQFLVRAPSSPLLLLEELGLKCSLMKLVKSLVWIFLCDV 78

Query: 57  ------------------HLSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAR 98
                             HL G+F RTI L+EAGIKPVYVFDGKPP  K++EL KR   R
Sbjct: 79  LCLYVFFVYVVIYMMFNRHLQGMFNRTIRLLEAGIKPVYVFDGKPPELKRQELAKRYSKR 138

Query: 99  EEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAA 158
            +A      A+  G+ E+  KY++R  KV +   +D K+LL+LMG+P+V+A SE EAQ A
Sbjct: 139 ADATADLTGAIEAGNKEDIEKYSKRTVKVTKQHNDDCKRLLRLMGVPVVEATSEAEAQCA 198

Query: 159 YMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKE 218
            +   G VY  AS+D DSL FG P+ +R+L     RK+P  +  V          ++L+E
Sbjct: 199 ALCKSGKVYGVASEDMDSLTFGAPKFLRHLMDPSSRKIPVMEFEV---------AKILEE 249

Query: 219 LKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKD--------PLAKFQRQSDV 270
           L++T ++ I+L IL G DY    I+GIG + AL++++               ++Q   + 
Sbjct: 250 LQLTMDQFIDLCILSGCDY-CDSIRGIGGQTALKLIRQHGSIETILENLNKERYQIPEEW 308

Query: 271 DLYAIKEFFLNPPTTDD---YSLKWKEPDEEGIIRFLCDEHDFSEERV 315
                ++ F  P    D     +KW  PDEEGI++FL +E+ F+ +RV
Sbjct: 309 PYNEARKLFKEPDVITDEEQLDIKWTSPDEEGIVQFLVNENGFNIDRV 356


>gb|AAG19690.1| (AE005056) DNA repair protein; Rad2 [Halobacterium sp. NRC-1]
           Length = 327
           
 Score =  164 bits (412), Expect = 1e-39
 Identities = 116/339 (34%), Positives = 169/339 (49%), Gaps = 28/339 (8%)

Query: 7   ELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMD-SKGRITSHLSGLFYRT 65
           +L   +E    +L G  +A+DA N +Y++L+T  Q  G  +   S G   ++L G     
Sbjct: 8   QLAAIEETPFADLEGSVVAVDAHNWLYKYLTTTVQWTGADVYTTSDGTEVANLVGAVQGL 67

Query: 66  INLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRAT 125
               E G+ PV+V+DG     K  E+  RRE RE  E +  +A   GD  EA +   R  
Sbjct: 68  PKFFEHGLTPVFVWDGGVTELKDDEIADRREQRERYEEQLDDAREAGDAAEAARLDARTQ 127

Query: 126 KVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGD-VYASASQDYDSLLFGTPRL 184
           ++   + E  ++L  L+ IP V+AP+EGEAQAAYM    D V  + S DYD LL G+P  
Sbjct: 128 RLTPTIHETTRELFDLLDIPQVEAPAEGEAQAAYMTRTDDAVDYAGSDDYDCLLLGSPVT 187

Query: 185 VRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKG 244
           +R LT +G              PEL+  +  L E  +T E+L+++ IL GTD+NP GI G
Sbjct: 188 LRQLTSSG-------------HPELMDFDATLAEHDLTWEQLVDVGILCGTDFNP-GIDG 233

Query: 245 IGPKKALEIVKYSKDPLAKFQRQSDVDLYA--IKEFFLNPPTTDDYSLKWKEPDEEGII- 301
            GP  AL+ +    D       + +   +   I+E FLNP  TDDY +   +PD    I 
Sbjct: 234 FGPTTALDAIGEHGDLWDVLAAEGEHVAHGDRIRELFLNPDVTDDYVI---DPDVSPAID 290

Query: 302 ---RFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESW 337
               F+ DE +   + V  G ER+     A  Q+ L+ W
Sbjct: 291 AARAFVTDEWEVDADAVARGFERID---AAAAQTGLDRW 326


>gb|AAD46833.1|AF160893_1 (AF160893) BcDNA.GM10765 [Drosophila melanogaster]
           Length = 726
           
 Score = 94.4 bits (231), Expect = 2e-18
 Identities = 72/258 (27%), Positives = 116/258 (44%), Gaps = 23/258 (8%)

Query: 6   GELIPRKEIE-LENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYR 64
           G L P  E + +  L GKK+AID    + + L+ +         D       HL  LF+R
Sbjct: 8   GVLTPHCERKPINELRGKKVAIDLAGWVCESLNVV---------DYFVHPRHHLKNLFFR 58

Query: 65  TINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRA 124
           T  L+   + PV+V +G  P  K + + KR E      ++++    K   E  +    + 
Sbjct: 59  TCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNE------LQFRGVKPKNSPECTQSQPSKG 112

Query: 125 TKVNEM---LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGT 181
            K       +++  + LL  MGI  VQ P E EA  A++   G V    SQD D   +G 
Sbjct: 113 DKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGA 172

Query: 182 PRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGG 241
            R+ RN +++ +         V+I      + E+   +   ++K+I +A+L G DY P G
Sbjct: 173 VRVYRNFSVSTQGAQAAAGGAVDIYD----MREITSRMDFGQQKIIVMALLCGCDYCPDG 228

Query: 242 IKGIGPKKALEIVKYSKD 259
           I GIG    L++    K+
Sbjct: 229 IGGIGKDGVLKLFNKYKE 246


>gb|AAF50805.1| (AE003567) BcDNA:GM10765 gene product [Drosophila melanogaster]
           Length = 726
           
 Score = 94.4 bits (231), Expect = 2e-18
 Identities = 72/258 (27%), Positives = 116/258 (44%), Gaps = 23/258 (8%)

Query: 6   GELIPRKEIE-LENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYR 64
           G L P  E + +  L GKK+AID    + + L+ +         D       HL  LF+R
Sbjct: 8   GVLTPHCERKPINELRGKKVAIDLAGWVCESLNVV---------DYFVHPRHHLKNLFFR 58

Query: 65  TINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRA 124
           T  L+   + PV+V +G  P  K + + KR E      ++++    K   E  +    + 
Sbjct: 59  TCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNE------LQFRGVKPKNSPECTQSQPSKG 112

Query: 125 TKVNEM---LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGT 181
            K       +++  + LL  MGI  VQ P E EA  A++   G V    SQD D   +G 
Sbjct: 113 DKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGA 172

Query: 182 PRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGG 241
            R+ RN +++ +         V+I      + E+   +   ++K+I +A+L G DY P G
Sbjct: 173 VRVYRNFSVSTQGAQAAAGGAVDIYD----MREITSRMDFGQQKIIVMALLCGCDYCPDG 228

Query: 242 IKGIGPKKALEIVKYSKD 259
           I GIG    L++    K+
Sbjct: 229 IGGIGKDGVLKLFNKYKE 246


>gb|AAC33874.1| (AF060479) exonuclease I [Homo sapiens]
           Length = 800
           
 Score = 89.3 bits (218), Expect = 6e-17
 Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)

Query: 50  SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
           +KG  T    G   + +N L+  GIKP+ VFDG     KK+    RRE R+   +K K+ 
Sbjct: 47  AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106

Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
           L +G + EAR+   R+  +   +     K  +  G+  + AP E +AQ AY+   G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166

Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
             ++D D L FG  +++  +   G          +EI    + +   L ++  T EK   
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217

Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
           + IL G DY    ++GIG  KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248


>gi|11426418 exonuclease 1 [Homo sapiens] >gi|3822433|gb|AAC69879.1| (AF091754)
           exonuclease Ib [Homo sapiens]
           Length = 846
           
 Score = 89.3 bits (218), Expect = 6e-17
 Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)

Query: 50  SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
           +KG  T    G   + +N L+  GIKP+ VFDG     KK+    RRE R+   +K K+ 
Sbjct: 47  AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106

Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
           L +G + EAR+   R+  +   +     K  +  G+  + AP E +AQ AY+   G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166

Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
             ++D D L FG  +++  +   G          +EI    + +   L ++  T EK   
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217

Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
           + IL G DY    ++GIG  KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248


>gi|10835226 exonuclease 1; rad2 nuclease family member, homolog of S.
           cerevisiae exonuclease 1 [Homo sapiens]
           >gi|4249655|gb|AAD13754.1| (AF084974) exonuclease I
           [Homo sapiens]
           Length = 846
           
 Score = 89.3 bits (218), Expect = 6e-17
 Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)

Query: 50  SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
           +KG  T    G   + +N L+  GIKP+ VFDG     KK+    RRE R+   +K K+ 
Sbjct: 47  AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106

Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
           L +G + EAR+   R+  +   +     K  +  G+  + AP E +AQ AY+   G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166

Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
             ++D D L FG  +++  +   G          +EI    + +   L ++  T EK   
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217

Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
           + IL G DY    ++GIG  KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248


>gi|11426420 Rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
           [Homo sapiens] >gi|3445182|gb|AAC32424.1| (AC004783)
           Hex1 [Homo sapiens] >gi|3822434|gb|AAC69880.1|
           (AF091754) exonuclease Ia [Homo sapiens]
           Length = 803
           
 Score = 89.3 bits (218), Expect = 6e-17
 Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)

Query: 50  SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
           +KG  T    G   + +N L+  GIKP+ VFDG     KK+    RRE R+   +K K+ 
Sbjct: 47  AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106

Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
           L +G + EAR+   R+  +   +     K  +  G+  + AP E +AQ AY+   G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166

Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
             ++D D L FG  +++  +   G          +EI    + +   L ++  T EK   
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217

Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
           + IL G DY    ++GIG  KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248


>gi|6753788 exonuclease 1 [Mus musculus] >gi|5689874|emb|CAB51863.1| (AJ238213)
           exonuclease 1 homologue [Mus musculus]
           Length = 837
           
 Score = 89.3 bits (218), Expect = 6e-17
 Identities = 60/212 (28%), Positives = 104/212 (48%), Gaps = 11/212 (5%)

Query: 50  SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
           +KG  T    G   + +N L+  G+KP+ +FDG     KK+    RRE R+   +K K+ 
Sbjct: 47  AKGEPTDRYVGFCMKFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQL 106

Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
           L +G + EAR    R+  +   +     K  + +G+  + AP E +AQ AY+   G V A
Sbjct: 107 LREGKVSEARDCFARSINITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQA 166

Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
             ++D D L FG  +++  +   G          +E+    + + + L ++  T EK   
Sbjct: 167 VITEDSDLLAFGCKKVILKMDQFGNG--------LEVDQARLGMCKQLGDV-FTEEKFRY 217

Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
           + IL G DY    ++GIG  KA ++++ + +P
Sbjct: 218 MCILSGCDY-LASLRGIGLAKACKVLRLANNP 248


>gi|4504369 exonuclease 1; rad2 nuclease family member, homolog of S.
           cerevisiae exonuclease 1 [Homo sapiens]
           >gi|3170238|gb|AAC32259.1| (AF042282) Hex1 [Homo
           sapiens] >gi|3703096|gb|AAC63043.1| (AF091740)
           exonuclease 1a [Homo sapiens]
           Length = 803
           
 Score = 89.3 bits (218), Expect = 6e-17
 Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)

Query: 50  SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
           +KG  T    G   + +N L+  GIKP+ VFDG     KK+    RRE R+   +K K+ 
Sbjct: 47  AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106

Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
           L +G + EAR+   R+  +   +     K  +  G+  + AP E +AQ AY+   G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166

Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
             ++D D L FG  +++  +   G          +EI    + +   L ++  T EK   
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217

Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
           + IL G DY    ++GIG  KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248


>gb|AAF76467.1|AC020622_1 (AC020622) Contains similarity to excision repair protein ERCC5
           from Homo sapiens gi|1082359 and contains XPG N-terminal
           PF|00752 and XPG I-region PF|00867 domains. [Arabidopsis
           thaliana]
           Length = 497
           
 Score = 84.3 bits (205), Expect = 2e-15
 Identities = 64/216 (29%), Positives = 103/216 (47%), Gaps = 22/216 (10%)

Query: 57  HLSGLFYRTINLMEA-GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIE 115
           HL   F+RTINL    G  PV+V DG P   K  +    R  R          + K  + 
Sbjct: 51  HLRLTFFRTINLFSKFGAYPVFVVDGTPSPLKS-QARISRFFRSSGIDTCNLPVIKDGVS 109

Query: 116 EARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYD 175
             R       K+    + +  +LL+L+GIP+++A  E EA  A +  +G V A  + D D
Sbjct: 110 VERN------KLFSEWVRECVELLELLGIPVLKANGEAEALCAQLNSQGFVDACITPDSD 163

Query: 176 SLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGT 235
           + LFG   +++++    +              E   +  +   L + R+ LI +++LVG 
Sbjct: 164 AFLFGAMCVIKDIKPNSREPF-----------ECYHMSHIESGLGLKRKHLIAISLLVGN 212

Query: 236 DYNPGGIKGIGPKKALEIVK-YSKDPLAKFQRQSDV 270
           DY+ GG+ GIG  KAL IV+ +S+D +   +R  D+
Sbjct: 213 DYDSGGVLGIGVDKALRIVREFSEDQV--LERLQDI 246


>pir||E71619 RAD2 endonuclease PFB0265c - malaria parasite (Plasmodium falciparum)
            >gi|3845138|gb|AAC71842.1| (AE001383) RAD2 endonuclease
            [Plasmodium falciparum]
            Length = 1516
            
 Score = 80.4 bits (195), Expect = 3e-14
 Identities = 75/265 (28%), Positives = 120/265 (44%), Gaps = 53/265 (20%)

Query: 114  IEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQD 173
            I+E +K  +   ++N+ + +D K LL   GIP +Q+P E EAQ +Y+  K    A  S D
Sbjct: 1194 IKEYKKLKKNNIEINDEMNDDIKLLLNFFGIPYIQSPCEAEAQCSYLNNKNYCDAIISDD 1253

Query: 174  YDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILV 233
             D L+F    +++N     K+K       VE+  +  + E    +L + +E+LI +++L 
Sbjct: 1254 SDVLVFSGKTVIKN--FFNKKKT------VEVYEKKAIEE----KLGLYQEELINISLLC 1301

Query: 234  GTDYNPGGIKGIGPKKALEIV---------KYSKDPLAKFQRQSDVDLY--AIKEF---- 278
            G DY   G+ GIG   ALEI+         K  KD ++   R+ D ++Y   I++F    
Sbjct: 1302 GCDYTI-GVHGIGIVNALEIIKAFPNFEDLKILKDIVSNPFRKIDKNMYNEEIQQFLNTH 1360

Query: 279  ---------------------FLNPPT-TDDYSLKWKEPDEEGIIRFLCDEHDFSEERVK 316
                                 F  P   TD    +W  PD + I +FL    + SEE+V 
Sbjct: 1361 KNYKLNWIFPNNFPDREVYKCFKYPKVCTDIKKFEWHVPDIKSITKFLHKTTNISEEKVL 1420

Query: 317  NGLERLKKAIKAG---KQSTLESWF 338
            N L  + +         QS +E +F
Sbjct: 1421 NVLNPILQKYNVNVRTYQSKIEDFF 1445


>gb|AAD31867.1|AF134570_1 (AF134570) exonuclease ExoI [Xenopus laevis]
           Length = 734
           
 Score = 79.2 bits (192), Expect = 6e-14
 Identities = 57/193 (29%), Positives = 92/193 (47%), Gaps = 10/193 (5%)

Query: 68  LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKV 127
           L+  G+KP+ VFDG     KK   + RRE R+    K K+ L +G + EAR+   R+  +
Sbjct: 66  LLSFGVKPILVFDGCTLPSKKDVEKARREKRQTNLQKGKQLLREGKLAEARECFSRSVNI 125

Query: 128 NEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRN 187
              +  +  K  +  G+  + AP E ++Q AY+       A  ++D D L FG  +++  
Sbjct: 126 TSSMAHEVIKAARSEGVDYIVAPYEADSQLAYLNKNDFAEAIITEDSDLLAFGCKKVLLK 185

Query: 188 LTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGP 247
           +   G          +EI      +   L ++  T EK   + IL G DY P  I GIG 
Sbjct: 186 MDKFGNG--------LEIDQARFGMCRSLGDV-FTEEKFRYMCILSGCDYLP-SIHGIGL 235

Query: 248 KKALEIVKYSKDP 260
            KA +++K + +P
Sbjct: 236 AKACKLLKVANNP 248


>sp|P28706|RA13_SCHPO DNA REPAIR PROTEIN RAD13 >gi|422055|pir||S30301 excision repair
           protein - fission yeast (Schizosaccharomyces pombe)
           >gi|5020|emb|CAA47291.1| (X66795) excision repair
           protein [Schizosaccharomyces pombe]
           Length = 1113
           
 Score = 76.9 bits (186), Expect = 3e-13
 Identities = 74/288 (25%), Positives = 127/288 (43%), Gaps = 52/288 (18%)

Query: 90  ELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQA 149
           EL +R E  E  +  +++ L +    +     + A +V +++I++ ++LL+L G+P + A
Sbjct: 716 ELNQRHETEEWNQEAFEKRLKEAQKSKKGSEKRDADEVTQVMIKECQELLRLFGLPYIVA 775

Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
           P E EAQ + +     V    + D D  LFG  R+ RN+    K        +V    EL
Sbjct: 776 PQEAEAQCSKLLELKLVDGIVTDDSDVFLFGGTRVYRNMFNQNK--------FV----EL 823

Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKDPLAKFQ---- 265
            +++++ +E  + +  LI+LA L+G+DY   G+  +GP  ALEI+         F+    
Sbjct: 824 YLMDDMKREFNVNQMDLIKLAHLLGSDYTM-GLSRVGPVLALEILHEFPGDTGLFEFKKW 882

Query: 266 ---------RQSDVDLYAIKEF------------FLNP--------PTTDD--YSLKWKE 294
                     ++DV+    K              F NP        P  DD   S +W  
Sbjct: 883 FQRLSTGHASKNDVNTPVKKRINKLVGKIILPSEFPNPLVDEAYLHPAVDDSKQSFQWGI 942

Query: 295 PDEEGIIRFLCDEHDFSEERVKNGL----ERLKKAIKAGKQSTLESWF 338
           PD + + +FL     +S++R    L    + + K    G QS L  +F
Sbjct: 943 PDLDELRQFLMATVGWSKQRTNEVLLPVIQDMHKKQFVGTQSNLTQFF 990


 Score = 73.4 bits (177), Expect = 4e-12
 Identities = 37/92 (40%), Positives = 57/92 (61%), Gaps = 6/92 (6%)

Query: 11  RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLME 70
           ++ ++LE L  K++AIDA   IYQFL  +R ++G  L       +SH+ G F R   L+ 
Sbjct: 14  KRPVKLETLVNKRLAIDASIWIYQFLKAVRDKEGNQLK------SSHVVGFFRRICKLLF 67

Query: 71  AGIKPVYVFDGKPPAFKKKELEKRREAREEAE 102
            GIKPV+VFDG  P+ K++ ++KR+  R + E
Sbjct: 68  FGIKPVFVFDGGAPSLKRQTIQKRQARRLDRE 99


>gb|AAG12649.1|AC068667_30 (AC068667) exonuclease, putative; 92014-93872 [Arabidopsis
           thaliana]
           Length = 317
           
 Score = 76.1 bits (184), Expect = 5e-13
 Identities = 77/300 (25%), Positives = 134/300 (44%), Gaps = 21/300 (7%)

Query: 14  IELENLYGKKIAIDALNAIYQ-FLSTIRQRDGTPLMDSKGRITS-HLSGLFYRTINLMEA 71
           I ++ L G  +A+D  + +++  LS  R+         KG  T  H+    +R   L   
Sbjct: 17  IHIKELEGCIVAVDTYSWLHKGALSCSREL-------CKGLPTKRHIQYCMHRVNLLRHH 69

Query: 72  GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
           G+KP+ VFDG P   K ++  KR  +R+E   +  E  A G+   A +   +A  ++  +
Sbjct: 70  GVKPIMVFDGGPLPMKLEQENKRARSRKENLARALEHEANGNSSAAYECYSKAVDISPSI 129

Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
             +  ++L+   +  V AP E +AQ A++A    V A  ++D D + FG  R++  +   
Sbjct: 130 AHELIQVLRQENVDYVVAPYEADAQMAFLAITKQVDAIITEDSDLIPFGCLRIIFKMDKF 189

Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
           G          VE +   +   + L     + + L+E+ IL G DY    + G+G K+A 
Sbjct: 190 GHG--------VEFQASKLPKNKDLSLSGFSSQMLLEMCILSGCDYLQ-SLPGMGLKRAH 240

Query: 252 EIVKYSK--DPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDEHD 309
            ++   K  D + K  + S V +  + E             +  +P+ E II  LCD  D
Sbjct: 241 ALITKFKSYDRVIKHLKYSTVSVPPLYEESFKRALLTFKHQRVYDPNAEDIIH-LCDISD 299


>gi|6320469 involved in DNA repair; Din7p [Saccharomyces cerevisiae]
           >gi|2501673|sp|Q12086|DIN7_YEAST DNA-DAMAGE INDUCIBLE
           PROTEIN DIN7 >gi|2131229|pir||S61118 DIN7 protein -
           yeast (Saccharomyces cerevisiae)
           >gi|1134889|emb|CAA92581.1| (Z68290) unknown
           [Saccharomyces cerevisiae] >gi|1143552|emb|CAA62233.1|
           (X90707) DIN7 protein [Saccharomyces cerevisiae]
           >gi|1226039|emb|CAA94102.1| (Z70202) Din7p
           [Saccharomyces cerevisiae]
           Length = 430
           
 Score = 75.7 bits (183), Expect = 7e-13
 Identities = 78/275 (28%), Positives = 125/275 (45%), Gaps = 25/275 (9%)

Query: 1   MGVPIGELIPR-----KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRIT 55
           MG+P   L+P+     K++ L+    + +AID     Y +L          L+ +K   T
Sbjct: 1   MGIP--GLLPQLKRIQKQVSLKKYMYQTLAIDG----YAWLHRASCACAFELVMNKP--T 52

Query: 56  SHLSGLFYRTINLMEA-GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDI 114
           +     F + + L++   IKP  VFDG     K     +RR+ R E E+  K+  + G+ 
Sbjct: 53  NKYLQFFIKRLQLLKRLKIKPYIVFDGDSLFVKNHTETRRRKKRLENEMIAKKLWSAGNR 112

Query: 115 EEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDY 174
             A +Y Q++  +   + +      +L  IP + AP E + Q  Y+   G +    S+D 
Sbjct: 113 YNAMEYFQKSVDITPEMAKCIIDYCKLHSIPYIVAPFEADPQMVYLEKMGLIQGIISEDS 172

Query: 175 DSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVG 234
           D L+FG   L+  L   GK     KD +  + PE   L E      ++ ++   L  L G
Sbjct: 173 DLLVFGCKTLITKLNDQGKALEISKDDFSAL-PENFPLGE------LSEQQFRNLVCLAG 225

Query: 235 TDYNPGGIKGIGPKKALEIVK-YS--KDPLAKFQR 266
            DY   GI  +G   A++IVK YS  KD L + +R
Sbjct: 226 CDYT-SGIWKVGVVTAMKIVKRYSEMKDILIQIER 259


>pir||T40382 dna repair protein rad13 - fission yeast  (Schizosaccharomyces
           pombe) >gi|3130034|emb|CAA19011.1| (AL023534) dna repair
           protein rad13 [Schizosaccharomyces pombe]
           Length = 1112
           
 Score = 74.9 bits (181), Expect = 1e-12
 Identities = 76/288 (26%), Positives = 128/288 (44%), Gaps = 53/288 (18%)

Query: 90  ELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQA 149
           EL +R E  E  +  +++ L K    + R   + A +V +++I++ ++LL+L G+P + A
Sbjct: 716 ELNQRHETEEWNQEAFEKRL-KELKNQKRSEKRDADEVTQVMIKECQELLRLFGLPYIVA 774

Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
           P E EAQ + +     V    + D D  LFG  R+ RN+    K        +V    EL
Sbjct: 775 PQEAEAQCSKLLELKLVDGIVTDDSDVFLFGGTRVYRNMFNQNK--------FV----EL 822

Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKDPLAKFQ---- 265
            +++++ +E  + +  LI+LA L+G+DY   G+  +GP  ALEI+         F+    
Sbjct: 823 YLMDDMKREFNVNQMDLIKLAHLLGSDYTM-GLSRVGPVLALEILHEFPGDTGLFEFKKW 881

Query: 266 ---------RQSDVDLYAIKEF------------FLNP--------PTTDD--YSLKWKE 294
                     ++DV+    K              F NP        P  DD   S +W  
Sbjct: 882 FQRLSTGHASKNDVNTPVKKRINKLVGKIILPSEFPNPLVDEAYLHPAVDDSKQSFQWGI 941

Query: 295 PDEEGIIRFLCDEHDFSEERVKNGL----ERLKKAIKAGKQSTLESWF 338
           PD + + +FL     +S++R    L    + + K    G QS L  +F
Sbjct: 942 PDLDELRQFLMATVGWSKQRTNEVLLPVIQDMHKKQFVGTQSNLTQFF 989


 Score = 73.4 bits (177), Expect = 4e-12
 Identities = 37/92 (40%), Positives = 57/92 (61%), Gaps = 6/92 (6%)

Query: 11  RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLME 70
           ++ ++LE L  K++AIDA   IYQFL  +R ++G  L       +SH+ G F R   L+ 
Sbjct: 14  KRPVKLETLVNKRLAIDASIWIYQFLKAVRDKEGNQLK------SSHVVGFFRRICKLLF 67

Query: 71  AGIKPVYVFDGKPPAFKKKELEKRREAREEAE 102
            GIKPV+VFDG  P+ K++ ++KR+  R + E
Sbjct: 68  FGIKPVFVFDGGAPSLKRQTIQKRQARRLDRE 99


>sp|P53695|EXO1_SCHPO EXONUCLEASE I (EXO I) >gi|7490548|pir||T40060 exonuclease i -
           fission yeast (Schizosaccharomyces pombe)
           >gi|11359238|pir||T43288 probable exodeoxyribonuclease I
           (EC 3.1.11.1) - fission yeast (Schizosaccharomyces
           pombe) >gi|703466|gb|AAC41648.1| (L35174) exonuclease
           [Schizosaccharomyces pombe] >gi|4007793|emb|CAA22433.1|
           (AL034463) exonuclease i [Schizosaccharomyces pombe]
           Length = 571
           
 Score = 73.7 bits (178), Expect = 3e-12
 Identities = 68/259 (26%), Positives = 113/259 (43%), Gaps = 16/259 (6%)

Query: 5   IGELIP-RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFY 63
           +G L P +K   +E   GK + +D    +++ + T         +        +L    +
Sbjct: 7   LGLLKPMQKSSHVEEFSGKTLGVDGYVWLHKAVFTCAHE-----LAFNKETDKYLKYAIH 61

Query: 64  RTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQR 123
           + + L   G+KP+ VFDG P   K    +KR+E R+EA    K+   +G   +A     R
Sbjct: 62  QALMLQYYGVKPLIVFDGGPLPCKASTEQKRKERRQEAFELGKKLWDEGKKSQAIMQFSR 121

Query: 124 ATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPR 183
              V   +       L+  GI  + AP E +AQ  Y+  +  +    ++D D L+FG   
Sbjct: 122 CVDVTPEMAWKLIIALREHGIESIVAPYEADAQLVYLEKENIIDGIITEDSDMLVFGAQT 181

Query: 184 LVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIK 243
           ++         KM G    + I+   I   + L  L++  EKL  +AI  G DY   G+ 
Sbjct: 182 VL--------FKMDGFGNCITIRRNDIANAQDL-NLRLPIEKLRHMAIFSGCDYT-DGVA 231

Query: 244 GIGPKKALEIVKYSKDPLA 262
           G+G K AL  ++   +P A
Sbjct: 232 GMGLKTALRYLQKYPEPRA 250


>gi|6321697 homolog of xeroderma pigmentosum group G (XPG) protein, copufurifies
            with transcription factor, TFIIH, mRNA is cell cycle
            regulated and induced by DNA damage and by meiosis
            (different cis-sites utilized in damage and meiotic
            induction; Rad2p [Saccharom>
            >gi|131811|sp|P07276|RAD2_YEAST DNA REPAIR PROTEIN RAD2
            >gi|83443|pir||A29839 RAD2 protein - yeast (Saccharomyces
            cerevisiae) >gi|172329|gb|AAA66928.1| (M10275) RAD2
            [Saccharomyces cerevisiae] >gi|1323470|emb|CAA97287.1|
            (Z73043) ORF YGR258c [Saccharomyces cerevisiae]
            Length = 1031
            
 Score = 72.6 bits (175), Expect = 6e-12
 Identities = 80/310 (25%), Positives = 130/310 (41%), Gaps = 60/310 (19%)

Query: 67   NLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDI-EEARKYAQRAT 125
            N++E  IK    FD     FK   L    E R  AE     A  + ++ E+  K  + + 
Sbjct: 715  NIVENMIKEQEEFD----TFKNTTLSTSAE-RNVAE----NAFVEDELFEQQMKDKRDSD 765

Query: 126  KVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLV 185
            +V   +I++ ++LL   GIP + AP E EAQ A +     V    + D D  LFG  ++ 
Sbjct: 766  EVTMDMIKEVQELLSRFGIPYITAPMEAEAQCAELLQLNLVDGIITDDSDVFLFGGTKIY 825

Query: 186  RNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGI 245
            +N        M  +  YVE        E +LK L + R+ +IELA L+G+DY   G+KG+
Sbjct: 826  KN--------MFHEKNYVEFYD----AESILKLLGLDRKNMIELAQLLGSDYT-NGLKGM 872

Query: 246  GPKKALEIV---------------------------KYSKDPLAKFQR-----QSDVDLY 273
            GP  ++E++                           K+ KD   K          D    
Sbjct: 873  GPVSSIEVIAEFGNLKNFKDWYNNGQFDKRKQETENKFEKDLRKKLVNNEIILDDDFPSV 932

Query: 274  AIKEFFLNPPTTDDYS-LKWKEPDEEGIIRFLCDE----HDFSEERVKNGLERLKKAIKA 328
             + + ++ P    D +   W  PD + +  F+  +    H+ S+E +   +  + K  K 
Sbjct: 933  MVYDAYMRPEVDHDTTPFVWGVPDLDMLRSFMKTQLGWPHEKSDEILIPLIRDVNKRKKK 992

Query: 329  GKQSTLESWF 338
            GKQ  +  +F
Sbjct: 993  GKQKRINEFF 1002


 Score = 69.5 bits (167), Expect = 5e-11
 Identities = 33/88 (37%), Positives = 55/88 (62%), Gaps = 6/88 (6%)

Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
          + + LE+L  K++A+DA   IYQFL  +R ++G  + +S      H++G F R   L+  
Sbjct: 15 RPVRLESLEDKRMAVDASIWIYQFLKAVRDQEGNAVKNS------HITGFFRRICKLLYF 68

Query: 72 GIKPVYVFDGKPPAFKKKELEKRREARE 99
          GI+PV+VFDG  P  K++ + +R+E R+
Sbjct: 69 GIRPVFVFDGGVPVLKRETIRQRKERRQ 96


>gi|6324607 exonuclease; Dhs1p [Saccharomyces cerevisiae]
           >gi|1706421|sp|P39875|EXO1_YEAST EXONUCLEASE I (EXO I)
           (DHS1 PROTEIN) >gi|2131226|pir||S62169 DHS1 protein -
           yeast (Saccharomyces cerevisiae)
           >gi|1041655|emb|CAA60749.1| (X87331) overlaps with
           S69545. Encodes protein 219 amino acids longer than
           published protein sequence [Saccharomyces cerevisiae]
           >gi|1420150|emb|CAA99223.1| (Z74941) ORF YOR033c
           [Saccharomyces cerevisiae] >gi|1840127|gb|AAB47428.1|
           (U86134) Exo1p [Saccharomyces cerevisiae]
           Length = 702
           
 Score = 72.6 bits (175), Expect = 6e-12
 Identities = 56/205 (27%), Positives = 97/205 (47%), Gaps = 9/205 (4%)

Query: 52  GRITSHLSGLFYRTINLMEA-GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALA 110
           G+ T      F +  +L++   ++P  VFDG     KK    KRR+ R+E +   +   A
Sbjct: 49  GKPTDKYLQFFIKRFSLLKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWA 108

Query: 111 KGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASA 170
            G+ + A  Y Q+   +   + +      +L GI  + AP E ++Q  Y+  K  V    
Sbjct: 109 CGEKKNAMDYFQKCVDITPEMAKCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGII 168

Query: 171 SQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELA 230
           S+D D L+FG  RL+  L   G+     +D ++++ P+   L        +T E++I + 
Sbjct: 169 SEDSDLLVFGCRRLITKLNDYGECLEICRDNFIKL-PKKFPLG------SLTNEEIITMV 221

Query: 231 ILVGTDYNPGGIKGIGPKKALEIVK 255
            L G DY   GI  +G   A+++V+
Sbjct: 222 CLSGCDYT-NGIPKVGLITAMKLVR 245


>gb|AAD38375.1|AF144092_1 (AF144092) nucleotide excision repair protein MUS201 [Drosophila
            melanogaster] >gi|7297419|gb|AAF52678.1| (AE003621)
            mus201 gene product [alt 2] [Drosophila melanogaster]
            Length = 1236
            
 Score = 71.4 bits (172), Expect = 1e-11
 Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)

Query: 91   LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
            L+ ++ + E  E+    A  + ++E  R    R    +++ +  D ++LL+L GIP + A
Sbjct: 818  LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 877

Query: 150  PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
            P E EAQ A++      + + + D D  LFG   + +N     K  M  +          
Sbjct: 878  PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 927

Query: 210  IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
               E++ +     R KLI+LA LVG+DY   GI GIG   ALEI                
Sbjct: 928  --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGQDANGPGICN 984

Query: 254  -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
                   +K+               S   LA  ++  +++L+      A+ E +L  PT 
Sbjct: 985  QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1043

Query: 286  DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
            DD   +  W  PD E I  F      ++  +  + L  + K I   K Q ++ ++F  K
Sbjct: 1044 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1102


>gb|AAD50779.1|AF162792_1 (AF162792) XPG [Drosophila melanogaster]
            Length = 1236
            
 Score = 71.4 bits (172), Expect = 1e-11
 Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)

Query: 91   LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
            L+ ++ + E  E+    A  + ++E  R    R    +++ +  D ++LL+L GIP + A
Sbjct: 818  LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 877

Query: 150  PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
            P E EAQ A++      + + + D D  LFG   + +N     K  M  +          
Sbjct: 878  PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 927

Query: 210  IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
               E++ +     R KLI+LA LVG+DY   GI GIG   ALEI                
Sbjct: 928  --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGRDANGPGICN 984

Query: 254  -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
                   +K+               S   LA  ++  +++L+      A+ E +L  PT 
Sbjct: 985  QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1043

Query: 286  DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
            DD   +  W  PD E I  F      ++  +  + L  + K I   K Q ++ ++F  K
Sbjct: 1044 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1102


>gb|AAD50780.1|AF162793_1 (AF162793) XPG variant [Drosophila melanogaster]
            Length = 1257
            
 Score = 71.4 bits (172), Expect = 1e-11
 Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)

Query: 91   LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
            L+ ++ + E  E+    A  + ++E  R    R    +++ +  D ++LL+L GIP + A
Sbjct: 839  LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 898

Query: 150  PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
            P E EAQ A++      + + + D D  LFG   + +N     K  M  +          
Sbjct: 899  PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 948

Query: 210  IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
               E++ +     R KLI+LA LVG+DY   GI GIG   ALEI                
Sbjct: 949  --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGRDANGPGICN 1005

Query: 254  -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
                   +K+               S   LA  ++  +++L+      A+ E +L  PT 
Sbjct: 1006 QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1064

Query: 286  DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
            DD   +  W  PD E I  F      ++  +  + L  + K I   K Q ++ ++F  K
Sbjct: 1065 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1123


>gb|AAG22424.1| (AE003621) mus201 gene product [alt 1] [Drosophila melanogaster]
            Length = 1257
            
 Score = 71.4 bits (172), Expect = 1e-11
 Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)

Query: 91   LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
            L+ ++ + E  E+    A  + ++E  R    R    +++ +  D ++LL+L GIP + A
Sbjct: 839  LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 898

Query: 150  PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
            P E EAQ A++      + + + D D  LFG   + +N     K  M  +          
Sbjct: 899  PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 948

Query: 210  IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
               E++ +     R KLI+LA LVG+DY   GI GIG   ALEI                
Sbjct: 949  --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGQDANGPGICN 1005

Query: 254  -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
                   +K+               S   LA  ++  +++L+      A+ E +L  PT 
Sbjct: 1006 QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1064

Query: 286  DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
            DD   +  W  PD E I  F      ++  +  + L  + K I   K Q ++ ++F  K
Sbjct: 1065 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1123


>gi|4503601 XPG-complementing protein; excision repair cross-complementing
           rodent repair deficiency, complementation group 5;
           xeroderma pigmentosum complementation group G;
           Excision-repair, complementing defective, in Chinese
           hamster, [Homo sapiens] >gi|267420|sp|P28715|XPG_HUMAN
           DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS (XERODERMA
           PIGMENTOSUM GROUP G COMPLEMENTING PROTEIN) (DNA EXCISION
           REPAIR PROTEIN ERCC-5) >gi|423150|pir||S35993 DNA repair
           protein XPGC - human >gi|298111|emb|CAA49598.1| (X69978)
           XP-G factor [Homo sapiens]
           Length = 1186
           
 Score = 70.6 bits (170), Expect = 2e-11
 Identities = 63/196 (32%), Positives = 92/196 (46%), Gaps = 25/196 (12%)

Query: 80  DGKPPAFKKKELEKRREAR----EEAEIKWKEALAKGDIEEARKYAQR---ATKVNEMLI 132
           DG+P   +K   +   E +    EE E      LA+ +  +A+K  Q    AT   +M +
Sbjct: 711 DGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFL 770

Query: 133 EDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITG 192
           E +++LL+L GIP +QAP E EAQ A +        + + D D  LFG   + RN     
Sbjct: 771 E-SQELLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRN--FFN 827

Query: 193 KRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALE 252
           K K      YV+             +L + R KLI LA L+G+DY   GI  +G   A+E
Sbjct: 828 KNKFVEYYQYVDFH----------NQLGLDRNKLINLAYLLGSDYTE-GIPTVGCVTAME 876

Query: 253 IVK----YSKDPLAKF 264
           I+     +  +PL KF
Sbjct: 877 ILNEFPGHGLEPLLKF 892


>pir||A54439 excision repair protein ERCC5 - human >gi|306742|gb|AAC37533.1|
           (L20046) excision repair protein [Homo sapiens]
           Length = 1186
           
 Score = 70.6 bits (170), Expect = 2e-11
 Identities = 63/196 (32%), Positives = 92/196 (46%), Gaps = 25/196 (12%)

Query: 80  DGKPPAFKKKELEKRREAR----EEAEIKWKEALAKGDIEEARKYAQR---ATKVNEMLI 132
           DG+P   +K   +   E +    EE E      LA+ +  +A+K  Q    AT   +M +
Sbjct: 711 DGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFL 770

Query: 133 EDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITG 192
           E +++LL+L GIP +QAP E EAQ A +        + + D D  LFG   + RN     
Sbjct: 771 E-SQELLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRN--FFN 827

Query: 193 KRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALE 252
           K K      YV+             +L + R KLI LA L+G+DY   GI  +G   A+E
Sbjct: 828 KNKFVEYYQYVDFH----------NQLGLDRNKLINLAYLLGSDYTE-GIPTVGCVTAME 876

Query: 253 IVK----YSKDPLAKF 264
           I+     +  +PL KF
Sbjct: 877 ILNEFPGHGLEPLLKF 892


>gb|AAF89179.1| (AF255442) xeroderma pigmentosum complementation group G protein
           splice variant [Homo sapiens]
           Length = 1186
           
 Score = 70.6 bits (170), Expect = 2e-11
 Identities = 63/196 (32%), Positives = 92/196 (46%), Gaps = 25/196 (12%)

Query: 80  DGKPPAFKKKELEKRREAR----EEAEIKWKEALAKGDIEEARKYAQR---ATKVNEMLI 132
           DG+P   +K   +   E +    EE E      LA+ +  +A+K  Q    AT   +M +
Sbjct: 711 DGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFL 770

Query: 133 EDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITG 192
           E +++LL+L GIP +QAP E EAQ A +        + + D D  LFG   + RN     
Sbjct: 771 E-SQELLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRN--FFN 827

Query: 193 KRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALE 252
           K K      YV+             +L + R KLI LA L+G+DY   GI  +G   A+E
Sbjct: 828 KNKFVEYYQYVDFH----------NQLGLDRNKLINLAYLLGSDYTE-GIPTVGCVTAME 876

Query: 253 IVK----YSKDPLAKF 264
           I+     +  +PL KF
Sbjct: 877 ILNEFPGHGLEPLLKF 892


>gb|AAD47568.1|AF125578_1 (AF125578) DNA repair endonuclease [Drosophila melanogaster]
            Length = 1236
            
 Score = 70.2 bits (169), Expect = 3e-11
 Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)

Query: 91   LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
            L+ ++ + E  E+    A  + ++E  R    R    +++ +  D ++LL+L GIP + A
Sbjct: 818  LKSQKTSGELQEMATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 877

Query: 150  PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
            P E EAQ A++      + + + D D  LFG   + +N     K  M  +          
Sbjct: 878  PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 927

Query: 210  IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
               E++ +     R KLI+LA LVG+DY   GI GIG   ALEI                
Sbjct: 928  --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGQDANGPGICN 984

Query: 254  -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
                   +K+               S   LA  ++  +++L+      A+ E +L  PT 
Sbjct: 985  QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1043

Query: 286  DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
            DD   +  W  PD E I  F      ++  +  + L  + K I   K Q ++ ++F  K
Sbjct: 1044 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1102


>pir||T22235 hypothetical protein F45G2.3 - Caenorhabditis elegans
           >gi|3877245|emb|CAB07612.1| (Z93382) contains similarity
           to Pfam domain: PF00752 (XPG N-terminal domain),
           Score=63.6, E-value=1.4e-15, N=1; PF00867 (XPG
           I-region), Score=98.9, E-value=3.3e-26, N=1; PF01576
           (Myosin tail), Score=34.7, E-value=1e-08, N=2~cDNA EST
           yk4a11.3 comes from>
           Length = 1287
           
 Score = 70.2 bits (169), Expect = 3e-11
 Identities = 89/319 (27%), Positives = 141/319 (43%), Gaps = 44/319 (13%)

Query: 19  LYGKKIAIDALNAIYQFLSTIRQRDGTPLMDS--KGRIT-SHLSGLFYRTINLMEAGIKP 75
           L GK +AID        +S +  R  T  MD    G  T S+++ +      L+  G   
Sbjct: 670 LRGKSVAID--------VSCLLHRGLTGCMDKIHMGEETQSYVNYVNKYVKELLGMGCHV 721

Query: 76  VYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDA 135
           V VFDG+P   KK   E+RRE RE+ +   +  LAKG   EAR   + AT ++  ++E+ 
Sbjct: 722 VMVFDGRPLPAKKGTNEERRELREKRKEHAEMLLAKGLEREARDTYRLATSISADIVENT 781

Query: 136 KKLLQLM-GIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRL-VRNLTITGK 193
            +  + M  + IV AP E +AQ AY+  +  V A  ++D D ++FG   +  +  + TG+
Sbjct: 782 IQYFRSMTNVDIVVAPYEADAQLAYLVQEKLVDAVITEDSDLIVFGCEMIYFKWQSATGE 841

Query: 194 RKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI 253
                  +Y +   +     E+  + K    K   + IL G DY   G+ G+G   A   
Sbjct: 842 -----CSVYEKCNLKNCFTGELGGD-KFDFVKFRRICILSGCDYLQAGLPGVGLSTA--- 892

Query: 254 VKYSKDPLAKFQRQSDVD-----LYAIKEFFLNPPTTDDYSLKWKE-PDEEGIIRFLCDE 307
                   AKF   + +      L  +  +  NP        K KE  ++E I  F   E
Sbjct: 893 --------AKFFSMTSIKDLRTLLRKVPSYLKNP--------KLKEHVNDEFIRNFEKAE 936

Query: 308 HDFSEERVKNGLERLKKAI 326
           + F  + V +  ER +K +
Sbjct: 937 NTFKHQIVFDPRERCQKPL 955


>emb|CAA61430.1| (X89021) Tosca [Drosophila melanogaster]
           Length = 732
           
 Score = 68.7 bits (165), Expect = 9e-11
 Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 24/254 (9%)

Query: 68  LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKV 127
           L+   IKP+ VFDG+    K    ++RR++R++++ +  E L  G IEEAR + +R   V
Sbjct: 66  LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDV 125

Query: 128 NEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRN 187
              +     +  +   +  + AP E +AQ A++          ++D D  LFG   ++  
Sbjct: 126 THDMTLRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFK 185

Query: 188 LTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGP 247
           L + G   +        ++ E + L     E K   +K   + IL G DY    + GIG 
Sbjct: 186 LDLNGSGLL--------VEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDY-LDSLPGIGL 236

Query: 248 KKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDE 307
            KA + +      L   Q    + L  I  +          +++  E D++ I  F+  E
Sbjct: 237 AKACKFI------LKTEQEDMRIALKKIPSYL---------NMRNLEVDDDYIENFMKAE 281

Query: 308 HDFSEERVKNGLER 321
             F    + N LER
Sbjct: 282 ATFRHMFIYNPLER 295


>emb|CAA61431.1| (X89022) Tosca [Drosophila melanogaster] >gi|7298467|gb|AAF53687.1|
           (AE003660) tos gene product [Drosophila melanogaster]
           Length = 732
           
 Score = 68.7 bits (165), Expect = 9e-11
 Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 24/254 (9%)

Query: 68  LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKV 127
           L+   IKP+ VFDG+    K    ++RR++R++++ +  E L  G IEEAR + +R   V
Sbjct: 66  LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDV 125

Query: 128 NEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRN 187
              +     +  +   +  + AP E +AQ A++          ++D D  LFG   ++  
Sbjct: 126 THDMALRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFK 185

Query: 188 LTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGP 247
           L + G   +        ++ E + L     E K   +K   + IL G DY    + GIG 
Sbjct: 186 LDLNGSGLL--------VEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDY-LDSLPGIGL 236

Query: 248 KKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDE 307
            KA + +      L   Q    + L  I  +          +++  E D++ I  F+  E
Sbjct: 237 AKACKFI------LKTEQEDMRIALKKIPSYL---------NMRNLEVDDDYIENFMKAE 281

Query: 308 HDFSEERVKNGLER 321
             F    + N LER
Sbjct: 282 ATFRHMFIYNPLER 295


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.316    0.137    0.385 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 130960674
Number of Sequences: 2977
Number of extensions: 5801016
Number of successful extensions: 16741
Number of sequences better than 1.0e-10: 53
Number of HSP's better than  0.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 16600
Number of HSP's gapped (non-prelim): 71
length of query: 343
length of database: 189,106,746
effective HSP length: 58
effective length of query: 285
effective length of database: 154,394,500
effective search space: 44002432500
effective search space used: 44002432500
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 165 (68.7 bits)