BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1877 (rad2) DE:DNA repair protein RAD2 (rad2)
(343 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||E75117 DNA repair protein rad2 (rad2) PAB1877 - Pyrococcus ... 685 0.0
pir||A71015 probable 5' nuclease - Pyrococcus horikoshii >gi|325... 651 0.0
pir||T46893 endo/exonuclease fen-1 [imported] - Pyrococcus furio... 627 e-179
gi|11497880 DNA repair protein RAD2 (rad2) [Archaeoglobus fulgid... 403 e-111
pir||H72765 probable flap endonuclease-1 APE0115 - Aeropyrum per... 400 e-110
pir||C64480 DNA repair protein RAD2 homolog - Methanococcus jann... 344 7e-94
gb|AAK40525.1| DNA repair endo/exonuclease FEN-1 (RAD2) (rad2) [... 335 3e-91
pir||C69085 DNA repair protein Rad2 - Methanobacterium thermoaut... 335 6e-91
emb|CAC12164.1| (AL445066) DNA repair protein RAD2 related prote... 303 1e-81
gb|AAB88707.1| (AF036327) flap endonuclease 1 [Xenopus laevis] 266 3e-70
gb|AAB06176.1| (U64563) 5' nuclease xFEN1a [Xenopus laevis] >gi|... 266 3e-70
gi|4758356 flap structure-specific endonuclease 1; RAD2 (S. pomb... 265 7e-70
gb|AAF60653.1| (AC024791) contains similarity to Pfam families P... 264 1e-69
gb|AAF81265.1|AF281018_1 (AF281018) flag structure-specific endo... 264 1e-69
gb|AAB08478.1| (U68141) XFEN1b [Xenopus laevis] 262 5e-69
pir||T13692 hypothetical protein EG0003.3 - fruit fly (Drosophil... 260 1e-68
gi|6322736 42 kDa 5' to 3' exonuclease required for Okazaki frag... 249 3e-65
gi|6679771 flap structure specific endonuclease 1 [Mus musculus]... 249 5e-65
sp|P39750|RAD2_SCHPO DNA REPAIR PROTEIN RAD2 >gi|1362231|pir||A5... 248 6e-65
dbj|BAA36171.1| (AB021666) FEN-1 [Oryza sativa] 245 5e-64
emb|CAB62862.1| (AL035475) putative flap exonuclease [Plasmodium... 227 2e-58
gb|AAG01445.1| (AF278764) flap endonuclease-1 [Plasmodium falcip... 227 2e-58
pir||T01198 endonuclease homolog F21E10.3 - Arabidopsis thaliana... 197 1e-49
gb|AAG19690.1| (AE005056) DNA repair protein; Rad2 [Halobacteriu... 164 1e-39
gb|AAD46833.1|AF160893_1 (AF160893) BcDNA.GM10765 [Drosophila me... 94 2e-18
gb|AAF50805.1| (AE003567) BcDNA:GM10765 gene product [Drosophila... 94 2e-18
gb|AAC33874.1| (AF060479) exonuclease I [Homo sapiens] 89 6e-17
gi|11426418 exonuclease 1 [Homo sapiens] >gi|3822433|gb|AAC69879... 89 6e-17
gi|10835226 exonuclease 1; rad2 nuclease family member, homolog ... 89 6e-17
gi|11426420 Rad2 nuclease family member, homolog of S. cerevisia... 89 6e-17
gi|6753788 exonuclease 1 [Mus musculus] >gi|5689874|emb|CAB51863... 89 6e-17
gi|4504369 exonuclease 1; rad2 nuclease family member, homolog o... 89 6e-17
gb|AAF76467.1|AC020622_1 (AC020622) Contains similarity to excis... 84 2e-15
pir||E71619 RAD2 endonuclease PFB0265c - malaria parasite (Plasm... 80 3e-14
gb|AAD31867.1|AF134570_1 (AF134570) exonuclease ExoI [Xenopus la... 79 6e-14
sp|P28706|RA13_SCHPO DNA REPAIR PROTEIN RAD13 >gi|422055|pir||S3... 77 3e-13
gb|AAG12649.1|AC068667_30 (AC068667) exonuclease, putative; 9201... 76 5e-13
gi|6320469 involved in DNA repair; Din7p [Saccharomyces cerevisi... 76 7e-13
pir||T40382 dna repair protein rad13 - fission yeast (Schizosac... 75 1e-12
sp|P53695|EXO1_SCHPO EXONUCLEASE I (EXO I) >gi|7490548|pir||T400... 74 3e-12
gi|6321697 homolog of xeroderma pigmentosum group G (XPG) protei... 73 6e-12
gi|6324607 exonuclease; Dhs1p [Saccharomyces cerevisiae] >gi|170... 73 6e-12
gb|AAD38375.1|AF144092_1 (AF144092) nucleotide excision repair p... 71 1e-11
gb|AAD50779.1|AF162792_1 (AF162792) XPG [Drosophila melanogaster] 71 1e-11
gb|AAD50780.1|AF162793_1 (AF162793) XPG variant [Drosophila mela... 71 1e-11
gb|AAG22424.1| (AE003621) mus201 gene product [alt 1] [Drosophil... 71 1e-11
gi|4503601 XPG-complementing protein; excision repair cross-comp... 71 2e-11
pir||A54439 excision repair protein ERCC5 - human >gi|306742|gb|... 71 2e-11
gb|AAF89179.1| (AF255442) xeroderma pigmentosum complementation ... 71 2e-11
gb|AAD47568.1|AF125578_1 (AF125578) DNA repair endonuclease [Dro... 70 3e-11
pir||T22235 hypothetical protein F45G2.3 - Caenorhabditis elegan... 70 3e-11
emb|CAA61430.1| (X89021) Tosca [Drosophila melanogaster] 69 9e-11
emb|CAA61431.1| (X89022) Tosca [Drosophila melanogaster] >gi|729... 69 9e-11
>pir||E75117 DNA repair protein rad2 (rad2) PAB1877 - Pyrococcus abyssi (strain
Orsay) >gi|5458165|emb|CAB49654.1| (AJ248285) DNA repair
protein RAD2 (rad2) [Pyrococcus abyssi]
Length = 343
Score = 685 bits (1748), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG
Sbjct: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
Query: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY
Sbjct: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG
Sbjct: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG
Sbjct: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300
GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI
Sbjct: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP 343
IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP
Sbjct: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP 343
>pir||A71015 probable 5' nuclease - Pyrococcus horikoshii
>gi|3257838|dbj|BAA30521.1| (AP000006) 343aa long
hypothetical 5' nuclease [Pyrococcus horikoshii]
Length = 343
Score = 651 bits (1660), Expect = 0.0
Identities = 314/343 (91%), Positives = 337/343 (97%)
Query: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
MGVPIG+L+PRKEI+LENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG
Sbjct: 1 MGVPIGDLVPRKEIDLENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
Query: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
LFYRTINLMEAGIKP YVFDGKPP FK+KELEKRREAREEAE+KWKEALAKG++EEARKY
Sbjct: 61 LFYRTINLMEAGIKPAYVFDGKPPEFKRKELEKRREAREEAELKWKEALAKGNLEEARKY 120
Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
AQRATKVNEMLIEDAKKLLQLMGIPI+QAPSEGEAQAAYMA KGDVYASASQDYDSLLFG
Sbjct: 121 AQRATKVNEMLIEDAKKLLQLMGIPIIQAPSEGEAQAAYMASKGDVYASASQDYDSLLFG 180
Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
PRL+RNLTITGKRKMPGKD+YVEIKPEL+VL+EVLKELKITREKLIELAILVGTDYNPG
Sbjct: 181 APRLIRNLTITGKRKMPGKDVYVEIKPELVVLDEVLKELKITREKLIELAILVGTDYNPG 240
Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300
G+KGIGPKKALEIV+YS+DPLAKFQRQSDVDLYAIKEFFLNPP T++YSL WKEPDEEGI
Sbjct: 241 GVKGIGPKKALEIVRYSRDPLAKFQRQSDVDLYAIKEFFLNPPVTNEYSLSWKEPDEEGI 300
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWFIKKKP 343
++FLCDEH+FSEERVKNG+ERLKKAIKAG+QSTLESWF+KKKP
Sbjct: 301 LKFLCDEHNFSEERVKNGIERLKKAIKAGRQSTLESWFVKKKP 343
>pir||T46893 endo/exonuclease fen-1 [imported] - Pyrococcus furiosus
>gi|6980604|pdb|1B43|A Chain A, Fen-1 From P. Furiosus
>gi|6980605|pdb|1B43|B Chain B, Fen-1 From P. Furiosus
>gi|4102602|gb|AAD01514.1| (AF013497) endo/exonuclease;
FEN-1 [Pyrococcus furiosus]
Length = 340
Score = 627 bits (1599), Expect = e-179
Identities = 307/338 (90%), Positives = 329/338 (96%)
Query: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
MGVPIGE+IPRKEIELENLYGKKIAIDALNAIYQFLSTIRQ+DGTPLMDSKGRITSHLSG
Sbjct: 1 MGVPIGEIIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQKDGTPLMDSKGRITSHLSG 60
Query: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
LFYRTINLMEAGIKPVYVFDG+PP FKKKELEKRREAREEAE KW+EAL KG+IEEARKY
Sbjct: 61 LFYRTINLMEAGIKPVYVFDGEPPEFKKKELEKRREAREEAEEKWREALEKGEIEEARKY 120
Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
AQRAT+VNEMLIEDAKKLL+LMGIPIVQAPSEGEAQAAYMA KG VYASASQDYDSLLFG
Sbjct: 121 AQRATRVNEMLIEDAKKLLELMGIPIVQAPSEGEAQAAYMAAKGSVYASASQDYDSLLFG 180
Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
PRLVRNLTITGKRK+PGK++YVEIKPELI+LEEVLKELK+TREKLIELAILVGTDYNPG
Sbjct: 181 APRLVRNLTITGKRKLPGKNVYVEIKPELIILEEVLKELKLTREKLIELAILVGTDYNPG 240
Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGI 300
GIKGIG KKALEIV++SKDPLAKFQ+QSDVDLYAIKEFFLNPP TD+Y+L W++PDEEGI
Sbjct: 241 GIKGIGLKKALEIVRHSKDPLAKFQKQSDVDLYAIKEFFLNPPVTDNYNLVWRDPDEEGI 300
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
++FLCDEHDFSEERVKNGLERLKKAIK+GKQSTLESWF
Sbjct: 301 LKFLCDEHDFSEERVKNGLERLKKAIKSGKQSTLESWF 338
>gi|11497880 DNA repair protein RAD2 (rad2) [Archaeoglobus fulgidus]
>gi|7446865|pir||H69282 DNA repair protein RAD2 (rad2)
homolog - Archaeoglobus fulgidus
>gi|2650376|gb|AAB90967.1| (AE001087) DNA repair protein
RAD2 (rad2) [Archaeoglobus fulgidus]
Length = 336
Score = 403 bits (1025), Expect = e-111
Identities = 204/340 (60%), Positives = 261/340 (76%), Gaps = 6/340 (1%)
Query: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
MG IG+L R+E+ELE GKKIA+DA N +YQF+S IRQ DGTPL DS+GRITSHLSG
Sbjct: 1 MGADIGDLFEREEVELEYFSGKKIAVDAFNTLYQFISIIRQPDGTPLKDSQGRITSHLSG 60
Query: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
+ YR N++E GI+PV+VFDG+PP FKK E+E+R++ R EAE W AL GD ++A+KY
Sbjct: 61 ILYRVSNMVEVGIRPVFVFDGEPPEFKKAEIEERKKRRAEAEEMWIAALQAGD-KDAKKY 119
Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
AQ A +V+E +++ AK LL MGIP V APSEGEAQAAYMA KGDV + SQDYDSLLFG
Sbjct: 120 AQAAGRVDEYIVDSAKTLLSYMGIPFVDAPSEGEAQAAYMAAKGDVEYTGSQDYDSLLFG 179
Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
+PRL RNL ITGKRK+PGK++YV++KPE+I+LE LK L +TRE+LI++AILVGTDYN
Sbjct: 180 SPRLARNLAITGKRKLPGKNVYVDVKPEIIILESNLKRLGLTREQLIDIAILVGTDYNE- 238
Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQR-QSDVD-LYAIKEFFLNPPTTDDYSLKWKEPDEE 298
G+KG+G KKAL +K D + + ++D + I+ FFLNPP TDDY ++++EPD E
Sbjct: 239 GVKGVGVKKALNYIKTYGDIFRALKALKVNIDHVEEIRNFFLNPPVTDDYRIEFREPDFE 298
Query: 299 GIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
I FLC+EHDFS ERV+ LE+L KA+K+ Q+TLE WF
Sbjct: 299 KAIEFLCEEHDFSRERVEKALEKL-KALKS-TQATLERWF 336
>pir||H72765 probable flap endonuclease-1 APE0115 - Aeropyrum pernix (strain
K1) >gi|5103505|dbj|BAA79026.1| (AP000058) 401aa long
hypothetical flap endonuclease-1 [Aeropyrum pernix]
Length = 401
Score = 400 bits (1017), Expect = e-110
Identities = 201/349 (57%), Positives = 264/349 (75%), Gaps = 11/349 (3%)
Query: 1 MGVPIGELIP---RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSH 57
+GV + ELIP R+E+EL L G +A+DA N +YQFL+ IRQ DGTPL+D +GR+TSH
Sbjct: 52 LGVNLRELIPPEARREVELRALSGYVLALDAYNMLYQFLTAIRQPDGTPLLDREGRVTSH 111
Query: 58 LSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEA 117
LSGLFYRTINL+E GIKPVYVFDGKPP K +E+E+R + EAE +++ A+ G++EEA
Sbjct: 112 LSGLFYRTINLVEEGIKPVYVFDGKPPEMKSREVEERLRRKAEAEARYRRAVEAGEVEEA 171
Query: 118 RKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSL 177
RKYA A ++ ++E++K+LL MG+P VQAP+EGEAQAAYMA KGD +A+ SQDYDSL
Sbjct: 172 RKYAMMAARLTSDMVEESKELLDAMGMPWVQAPAEGEAQAAYMARKGDAWATGSQDYDSL 231
Query: 178 LFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDY 237
LFG+PRLVRNL ITG+RK+PG+D YVEIKPE+I LE +L +L ITRE+LI + IL+GTDY
Sbjct: 232 LFGSPRLVRNLAITGRRKLPGRDQYVEIKPEIIELEPLLSKLGITREQLIAVGILLGTDY 291
Query: 238 NPGGIKGIGPKKALEIVKYSKDP---LAKFQR-QSDVD-LYAIKEFFLNPPTTDDYSLKW 292
NPGG++G GPK AL +VK DP LA R + D D L + E+FLNPP TDDY +++
Sbjct: 292 NPGGVRGYGPKTALRLVKSLGDPMKVLASVPRGEYDPDYLRKVYEYFLNPPVTDDYKIEF 351
Query: 293 KEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIK---AGKQSTLESWF 338
++PD++ + L + HDF+ ERV+ LERL KA + G+QS L+ WF
Sbjct: 352 RKPDQDKVREILVERHDFNPERVERALERLGKAYREKLRGRQSRLDMWF 400
>pir||C64480 DNA repair protein RAD2 homolog - Methanococcus jannaschii
>gi|5821777|pdb|1A76| Flap Endonuclease-1 From
Methanococcus Jannaschii >gi|5821778|pdb|1A77| Flap
Endonuclease-1 From Methanococcus Jannaschii
>gi|1592090|gb|AAB99454.1| (U67585) DNA repair protein
RAD2 (rad2) [Methanococcus jannaschii]
Length = 326
Score = 344 bits (874), Expect = 7e-94
Identities = 179/340 (52%), Positives = 243/340 (70%), Gaps = 17/340 (5%)
Query: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
MGV G+ IP+ I E+L GKK+AID +NA+YQFL++IR RDG+PL + KG ITS +G
Sbjct: 1 MGVQFGDFIPKNIISFEDLKGKKVAIDGMNALYQFLTSIRLRDGSPLRNRKGEITSAYNG 60
Query: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
+FY+TI+L+E I P++VFDG+PP K+K + RRE +E+AE+K KEA+ K D EEA KY
Sbjct: 61 VFYKTIHLLENDITPIWVFDGEPPKLKEKTRKVRREMKEKAELKMKEAIKKEDFEEAAKY 120
Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
A+R + + ++E+ K LL LMGIP V+APSEGEAQA+YMA KGDV+A SQDYD+LL+G
Sbjct: 121 AKRVSYLTPKMVENCKYLLSLMGIPYVEAPSEGEAQASYMAKKGDVWAVVSQDYDALLYG 180
Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
PR+VRNLT T + PELI L EVL++L+I+ + LI++AI +GTDYNPG
Sbjct: 181 APRVVRNLTTTKE------------MPELIELNEVLEDLRISLDDLIDIAIFMGTDYNPG 228
Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDLY-AIKEFFLNPPTTDDYSLKWKEPDEEG 299
G+KGIG K+A E+V + +AK + +V+ Y IK F P TD+YSL K PD+EG
Sbjct: 229 GVKGIGFKRAYELV---RSGVAKDVLKKEVEYYDEIKRIFKEPKVTDNYSLSLKLPDKEG 285
Query: 300 IIRFLCDEHDFSEERVKNGLERLKKAI-KAGKQSTLESWF 338
II+FL DE+DF+ +RVK +++L I KQ TL++WF
Sbjct: 286 IIKFLVDENDFNYDRVKKHVDKLYNLIANKTKQKTLDAWF 325
>gb|AAK40525.1| DNA repair endo/exonuclease FEN-1 (RAD2) (rad2) [Sulfolobus
solfataricus]
Length = 302
Score = 335 bits (851), Expect = 3e-91
Identities = 174/302 (57%), Positives = 230/302 (75%), Gaps = 11/302 (3%)
Query: 48 MDSKGRITSHLSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKE 107
MDS+GR+TSHLSGLFYRTIN++E G+ P+YVFDGKPP K +ELE+RR+A+EEAE K +
Sbjct: 1 MDSQGRVTSHLSGLFYRTINILEEGVIPIYVFDGKPPEQKSEELERRRKAKEEAERKLER 60
Query: 108 ALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVY 167
A ++G IEE RKY+Q +++ +++E++KKLL+ MGIPIVQAPSEGEA+AAY+ G +
Sbjct: 61 AKSEGKIEELRKYSQAILRLSNIMVEESKKLLRAMGIPIVQAPSEGEAEAAYLNKLGLSW 120
Query: 168 ASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLI 227
A+ASQDYD++LFG RLVRNLTITGKRK+P KD+YVEIKPELI E +LK+L ITRE+LI
Sbjct: 121 AAASQDYDAILFGAKRLVRNLTITGKRKLPNKDVYVEIKPELIETEILLKKLGITREQLI 180
Query: 228 ELAILVGTDYNPGGIKGIGPKKALEIV-KYSKDPLAK-----FQRQSDVDLYAIKEFFLN 281
++ IL+GTDYNP GI+GIGP++AL+I+ KY K A ++ + ++ I+ FLN
Sbjct: 181 DIGILIGTDYNPDGIRGIGPERALKIIKKYGKIEKAMEYGEISKKDINFNIDEIRGLFLN 240
Query: 282 PPTT-DDYSLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIK----AGKQSTLES 336
P + +L EP+ E II L EH+FSEERVKNG+ERL KAIK A +Q+ L+
Sbjct: 241 PQVVKPEEALDLNEPNGEDIINILVYEHNFSEERVKNGIERLTKAIKEAKGASRQTGLDR 300
Query: 337 WF 338
WF
Sbjct: 301 WF 302
>pir||C69085 DNA repair protein Rad2 - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622760|gb|AAB86106.1| (AE000922)
DNA repair protein Rad2 [Methanobacterium
thermoautotrophicum]
Length = 328
Score = 335 bits (849), Expect = 6e-91
Identities = 161/342 (47%), Positives = 243/342 (70%), Gaps = 18/342 (5%)
Query: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
MGV + +++ + I LE+L G+ +A+DA N +YQFLS+IRQRDGTPLMDS+GR+TSHLSG
Sbjct: 1 MGVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSG 60
Query: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
+ YRT +ME I+ +YVFDG+ K + + +R + R+++E++WK AL +GDI+ A+KY
Sbjct: 61 ILYRTAAVMEREIRVIYVFDGRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKY 120
Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
A R+++++ ++E +K+LL+L+GIP VQAP EGEAQA+YM GD +A ASQDYD LLFG
Sbjct: 121 AVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYMVKMGDAWAVASQDYDCLLFG 180
Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
PR+VRNLT++GK + PE+I LE L+EL I+ +L+++A+LVGTD+N
Sbjct: 181 APRVVRNLTLSGKLE----------DPEIIELESTLRELSISHTQLVDMALLVGTDFNE- 229
Query: 241 GIKGIGPKKALEIVKYSKDPLAKFQRQSDVDL----YAIKEFFLNPPTTDDYSLKWKEPD 296
G+KGIG ++ L++++ K + K R + D+ ++ FL P ++DY ++W++PD
Sbjct: 230 GVKGIGARRGLKLIR-EKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPD 288
Query: 297 EEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
EG+I FLC EH FSE+RV+ L++ + A + Q +LE WF
Sbjct: 289 VEGVIEFLCTEHGFSEDRVRAALKKFEGA--SSTQKSLEDWF 328
>emb|CAC12164.1| (AL445066) DNA repair protein RAD2 related protein [Thermoplasma
acidophilum]
Length = 336
Score = 303 bits (769), Expect = 1e-81
Identities = 160/339 (47%), Positives = 226/339 (66%), Gaps = 6/339 (1%)
Query: 1 MGVPIGELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSG 60
MG I +++ E L++ + +ID N +YQ LS +RQ DG PLMDS G +TSHL G
Sbjct: 1 MGTDISDIVVSHETSLKDQGNQTFSIDTYNILYQLLSNVRQYDGMPLMDSHGNVTSHLYG 60
Query: 61 LFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKY 120
+FYRTINL+E I+PVYVFDGKP K + + +R+ +E+A+ + +EA+ +G+ E+ R+Y
Sbjct: 61 IFYRTINLLENRIRPVYVFDGKPSPLKNRTISERQMMKEKAKAELEEAIERGE-EDLRQY 119
Query: 121 AQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFG 180
R + +++D KKLL MGIP V APSEGEAQA+YM K +V SQDYD LLFG
Sbjct: 120 YSRINYITPQIVDDTKKLLDYMGIPYVDAPSEGEAQASYMT-KKNVDGVISQDYDCLLFG 178
Query: 181 TPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPG 240
+++RN I G+RK+P K+IY + PE I+L+EVL +I +++LI + ILVGTD+N
Sbjct: 179 ARKILRNFAIYGRRKVPRKNIYKTVYPEYIILDEVLSANQINQDQLIGIGILVGTDFNE- 237
Query: 241 GIKGIGPKKALEIVKYSKD--PLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEE 298
GIKGIG KKAL ++K D + K ++ +L I +FF NPP DY K+++PD +
Sbjct: 238 GIKGIGAKKALALIKKEGDIKSVLKHIGKNIENLDEIIDFFKNPPVV-DYDFKFRKPDTD 296
Query: 299 GIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESW 337
I FLCDEHDFS ER+++ LE L+K +A Q L+S+
Sbjct: 297 AIEHFLCDEHDFSRERIRDHLESLRKNDQASTQFRLDSF 335
>gb|AAB88707.1| (AF036327) flap endonuclease 1 [Xenopus laevis]
Length = 382
Score = 266 bits (673), Expect = 3e-70
Identities = 145/338 (42%), Positives = 209/338 (60%), Gaps = 23/338 (6%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
KE ++++ +G+K+AIDA IYQFL +RQ DG L + +G TSHL G+FYRTI ++E
Sbjct: 19 KEHDIKSYFGRKVAIDASMCIYQFLIAVRQ-DGNTLQNEEGETTSHLMGMFYRTIRMVEH 77
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKPVYVFDGKPP K EL KR E R EAE + A G++E K+ +R KV +
Sbjct: 78 GIKPVYVFDGKPPQMKSGELAKRSERRAEAEKLLEAAEEAGEVENIEKFTKRLVKVTKQH 137
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
E+ KKLL LMGIP V AP E EA A + G VYA+A++D D+L FGTP L+R+LT +
Sbjct: 138 NEECKKLLTLMGIPYVDAPCEAEATCAALVKAGKVYAAATEDMDALTFGTPVLLRHLTAS 197
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+K+P ++ + L V++++ IT E+ ++L IL+G+DY I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LNRVIQDIGITHEQFVDLCILLGSDYCE-TIRGIGPKRAI 247
Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPT--TDDYSLKWKEPDEEGI 300
++++ K + + D+ Y + K FL P TD LKW EPDEEG+
Sbjct: 248 DLIRQHK-TIDEIIDNIDLKKYPVPENWLHKEAKHLFLEPEVVDTDITELKWIEPDEEGL 306
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
+ F+C E FSE+R++NG ++L K + Q L+ +F
Sbjct: 307 VAFMCGEKQFSEDRIRNGAKKLAKNRQGSTQGRLDDFF 344
>gb|AAB06176.1| (U64563) 5' nuclease xFEN1a [Xenopus laevis]
>gi|4106358|gb|AAD02814.1| (AF065397) flap endonuclease
1 [Xenopus laevis]
Length = 382
Score = 266 bits (672), Expect = 3e-70
Identities = 144/338 (42%), Positives = 209/338 (61%), Gaps = 23/338 (6%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
KE ++++ +G+K+A+DA IYQFL +RQ DG L + +G TSHL G+FYRTI ++E
Sbjct: 19 KEHDIKSYFGRKVAVDASMCIYQFLIAVRQ-DGNTLQNEEGETTSHLMGMFYRTIRMVEH 77
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKPVYVFDGKPP K EL KR E R EAE + A G++E K+ +R KV +
Sbjct: 78 GIKPVYVFDGKPPQMKSGELAKRSERRAEAEKLLEAAEEAGEVENIEKFTKRLVKVTKQH 137
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
E+ KKLL LMGIP V AP E EA A + G VYA+A++D D+L FGTP L+R+LT +
Sbjct: 138 NEECKKLLTLMGIPYVDAPCEAEATCAALVKAGKVYAAATEDMDALTFGTPVLLRHLTAS 197
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+K+P ++ + L V++++ IT E+ ++L IL+G+DY I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LNRVIQDIGITHEQFVDLCILLGSDYCE-TIRGIGPKRAI 247
Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPT--TDDYSLKWKEPDEEGI 300
++++ K + + D+ Y + K FL P TD LKW EPDEEG+
Sbjct: 248 DLIRQHK-TIDEIIDNIDLKKYPVPENWLHKEAKHLFLEPEVVDTDITELKWIEPDEEGL 306
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
+ F+C E FSE+R++NG ++L K + Q L+ +F
Sbjct: 307 VAFMCGEKQFSEDRIRNGAKKLAKNRQGSTQGRLDDFF 344
>gi|4758356 flap structure-specific endonuclease 1; RAD2 (S. pombe) homolog
[Homo sapiens] >gi|11439793|ref|XP_006414.1| flap
structure-specific endonuclease 1 [Homo sapiens]
>gi|729475|sp|P39748|FEN1_HUMAN FLAP ENDONUCLEASE-1
(MATURATION FACTOR 1) (MF1) >gi|1362788|pir||A56531 DNA
structure-specific endonuclease FEN1 [validated] - human
>gi|642090|gb|AAA91331.1| (L37374) endonuclease [Homo
sapiens] >gi|704377|gb|AAB32522.1| DNase IV=nuclear 42
kda 5' -> 3' exonuclease [human, HeLa cells, Peptide,
380 aa] >gi|3169155|gb|AAC23394.1| (AC004770)
FEN1_HUMAN; MATURATION FACTOR 1 (MF1); DNase IV;
RAD2_HUMAN [Homo sapiens] >gi|3980293|emb|CAA54166.1|
(X76771) flap endonuclease-1 [Homo sapiens]
Length = 380
Score = 265 bits (669), Expect = 7e-70
Identities = 143/338 (42%), Positives = 214/338 (63%), Gaps = 23/338 (6%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
+E ++++ +G+K+AIDA +IYQFL +RQ G L + +G TSHL G+FYRTI +ME
Sbjct: 19 RENDIKSYFGRKVAIDASMSIYQFLIAVRQ-GGDVLQNEEGETTSHLMGMFYRTIRMMEN 77
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKPVYVFDGKPP K EL KR E R EAE + ++A A G +E K+ +R KV +
Sbjct: 78 GIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQH 137
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
++ K LL LMGIP + APSE EA A + G VYA+A++D D L FG+P L+R+LT +
Sbjct: 138 NDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTAS 197
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+K+P ++ + L +L+EL + +E+ ++L IL+G+DY I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LSRILQELGLNQEQFVDLCILLGSDYCE-SIRGIGPKRAV 247
Query: 252 EIVKYSKDPLAKFQRQSDVDLYAIKE---------FFLNPPTTDDYS--LKWKEPDEEGI 300
++++ K + + R+ D + Y + E FL P D S LKW EP+EE +
Sbjct: 248 DLIQKHKS-IEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEEL 306
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
I+F+C E FSEER+++G++RL K+ + Q L+ +F
Sbjct: 307 IKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFF 344
>gb|AAF60653.1| (AC024791) contains similarity to Pfam families PF00752 (XPG
N-terminal domain, score=189.5, E=5.3e-53, N=1) and
PF00867 (XPG I-region, score=138.6, E=1.1e-37, N=1)
[Caenorhabditis elegans]
Length = 382
Score = 264 bits (668), Expect = 1e-69
Identities = 141/334 (42%), Positives = 208/334 (62%), Gaps = 21/334 (6%)
Query: 15 ELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEAGIK 74
E++ +G+ +AIDA +YQFL +RQ DG+ L G TSHL G+ RT+ + E G+K
Sbjct: 22 EMKAFFGRTVAIDASMCLYQFLIAVRQ-DGSQLQSEDGETTSHLMGMLNRTVRMFENGVK 80
Query: 75 PVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIED 134
PVYVFDGKPP K ELEKR E R EAE EA KGD++EA K+ +R KV + ++
Sbjct: 81 PVYVFDGKPPDMKGGELEKRSERRAEAEKALTEAKEKGDVKEAEKFERRLVKVTKQQNDE 140
Query: 135 AKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKR 194
AK+LL LMGIP+V+AP E EAQ A++ G V+ + ++D D+L FG+ L+R+ +
Sbjct: 141 AKRLLGLMGIPVVEAPCEAEAQCAHLVKAGKVFGTVTEDMDALTFGSTVLLRHFLAPVAK 200
Query: 195 KMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIV 254
K+P K+ + + L+E+K++ E+ I+L IL+G DY G I+G+GPKKA+E++
Sbjct: 201 KIPIKEFNLSL---------ALEEMKLSVEEFIDLCILLGCDY-CGTIRGVGPKKAVELI 250
Query: 255 KYSKD--------PLAKFQRQSDVDLYAIKEFFLNPPTT--DDYSLKWKEPDEEGIIRFL 304
+ K+ K+ D +E FLNP T ++ L WKE D EG+I+FL
Sbjct: 251 RQHKNIETILENIDQNKYPPPEDWPYKRARELFLNPEVTKPEEVELTWKEADVEGVIQFL 310
Query: 305 CDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
C E +F+EER++N L +LK + K+G Q ++S+F
Sbjct: 311 CGEKNFNEERIRNALAKLKTSRKSGTQGRIDSFF 344
>gb|AAF81265.1|AF281018_1 (AF281018) flag structure-specific endonuclease [Rattus norvegicus]
Length = 380
Score = 264 bits (667), Expect = 1e-69
Identities = 140/338 (41%), Positives = 214/338 (62%), Gaps = 23/338 (6%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
+E ++++ +G+K+AIDA +IYQFL +RQ G L + +G TSHL G+FYRTI +ME
Sbjct: 19 RENDIKSYFGRKVAIDASMSIYQFLIAVRQ-GGDVLQNEEGETTSHLMGMFYRTIRMMEN 77
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKPVY+FDGKPP K +L KR E R EAE + ++A G EE K+ +R KV +
Sbjct: 78 GIKPVYIFDGKPPQLKSAQLAKRSERRAEAEKQLQQAQEAGAEEEVEKFTKRLVKVTKQH 137
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
++ K LL LMGIP + APSE EA A +A G VYA+A++D D L FG+P L+R+LT +
Sbjct: 138 NDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSPVLMRHLTAS 197
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+K+P ++ + L VL+EL + +E+ ++L IL+G+DY ++GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LSRVLQELGLNQEQFVDLCILLGSDYCE-SVRGIGPKRAV 247
Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPTTDDYS--LKWKEPDEEGI 300
++++ K + + R+ D Y + ++ FL P D S LKW EP+EE +
Sbjct: 248 DLIQKHKS-IEEIVRRLDPSKYPVPENWLHKEARQLFLEPEVVDPESVELKWSEPNEEEL 306
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
++F+C E FSEER+++G++RL K+ + Q L+ +F
Sbjct: 307 VKFMCGEKQFSEERIRSGVKRLNKSRQGSTQGRLDDFF 344
>gb|AAB08478.1| (U68141) XFEN1b [Xenopus laevis]
Length = 382
Score = 262 bits (662), Expect = 5e-69
Identities = 142/338 (42%), Positives = 207/338 (61%), Gaps = 23/338 (6%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
KE ++++ +G+K+A+DA IYQFL +RQ DG L + +G TSHL G+FYRTI ++E
Sbjct: 19 KEHDIKSYFGRKVAVDASMCIYQFLIAVRQ-DGNMLQNEEGETTSHLMGMFYRTIRMLEH 77
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKPVYVFDGKPP K EL KR E R EAE + A G++E K+ +R KV +
Sbjct: 78 GIKPVYVFDGKPPQMKSGELAKRSERRAEAEKLLEAAEEAGEVENIEKFNKRLVKVTKQH 137
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
E+ KKLL LMGIP V AP E EA A + G VYA+A++D D+L FGTP L+R+LT +
Sbjct: 138 NEECKKLLSLMGIPYVDAPCEAEATCAALVKAGKVYAAATEDMDALTFGTPVLLRHLTAS 197
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+K+P ++ + L V +++ I E+ ++L IL+G+DY I+GIGPK+A+
Sbjct: 198 EAKKLPIQEFH---------LNRVFQDIGINHEQFVDLCILLGSDYCE-TIRGIGPKRAI 247
Query: 252 EIVKYSKDPLAKFQRQSDVDLYAI---------KEFFLNPPT--TDDYSLKWKEPDEEGI 300
++++ K + + D+ Y I ++ FL P D LKW EPDEEG+
Sbjct: 248 DLIRQHK-TIEEIIDNIDLKKYPIPENWLHKEARQLFLEPEVIDADITELKWTEPDEEGL 306
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
+ F+C E FSE+R++NG ++L K + Q L+ +F
Sbjct: 307 VAFMCGEKQFSEDRIRNGAKKLAKNRQGSTQGRLDDFF 344
>pir||T13692 hypothetical protein EG0003.3 - fruit fly (Drosophila melanogaster)
>gi|3929699|emb|CAA21320.1| (AL031863)
1-evidence=predicted by
match~1-match_accession=SWISS-PROT:P39748~1-
match_description=FLAP ENDONUCLEASE-1 (MATURATION FACTOR
1) (MF1).~1-match_species=HOMO SAPIENS
(HUMAN).~1-method=blastx;1.4.9~1-method_score=102.00;
1129.00~1-evidence_end~> >gi|7302871|gb|AAF57944.1|
(AE003805) EG:EG0003.3 gene product [Drosophila
melanogaster]
Length = 385
Score = 260 bits (658), Expect = 1e-68
Identities = 147/346 (42%), Positives = 210/346 (60%), Gaps = 23/346 (6%)
Query: 5 IGELIPR--KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLF 62
I +L P+ +E E+++ +G+K+AIDA +YQFL +R +G L G TSHL G+F
Sbjct: 10 IADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRS-EGAQLATVNGDPTSHLMGMF 68
Query: 63 YRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQ 122
YRTI L++ GIKPVYVFDGKPP K EL KR E REEAE K A GD K+ +
Sbjct: 69 YRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNR 128
Query: 123 RATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTP 182
R +V + ++AK+LL LMG+P V AP E EAQ A + G VYA+A++D D+L FG+
Sbjct: 129 RLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGST 188
Query: 183 RLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGI 242
+L+R LT + RKMP K+ +++L+ L I + I+L IL+G DY I
Sbjct: 189 KLLRYLTYSEARKMPVKE---------FSYDKLLEGLAINNREFIDLCILLGCDYCE-SI 238
Query: 243 KGIGPKKALEIVKYSKD--------PLAKFQRQSDVDLYAIKEFFLNPPT--TDDYSLKW 292
KGIGPK+A+E++ +D +K+ + + +E F+ P D LKW
Sbjct: 239 KGIGPKRAIELINTYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVADADSIDLKW 298
Query: 293 KEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
EPDEEG+++FLC + F+EERV+NG ++L K+ +A Q L+S+F
Sbjct: 299 VEPDEEGLVKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFF 344
>gi|6322736 42 kDa 5' to 3' exonuclease required for Okazaki fragment
processing; Rad27p [Saccharomyces cerevisiae]
>gi|140964|sp|P26793|RA27_YEAST STRUCTURE SPECIFIC
ENDONUCLEASE RAD27 >gi|320768|pir||S22267 hypothetical
protein YKL113c - yeast (Saccharomyces cerevisiae)
>gi|248392|gb|AAB21998.1| (S93804) RAD2 homolog=YKL510
[Saccharomyces cerevisiae, Peptide, 382 aa]
>gi|486190|emb|CAA81953.1| (Z28113) ORF YKL113c
[Saccharomyces cerevisiae]
Length = 382
Score = 249 bits (630), Expect = 3e-65
Identities = 146/351 (41%), Positives = 216/351 (60%), Gaps = 30/351 (8%)
Query: 5 IGELIPR--KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLF 62
I E +P ++ ++++ +G+K+AIDA ++YQFL +RQ+DG L + G TSHL G+F
Sbjct: 10 ISEHVPSAIRKSDIKSFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMF 69
Query: 63 YRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQ 122
YRT+ +++ GIKP YVFDGKPP K EL KR R E E K EA + E K +
Sbjct: 70 YRTLRMIDNGIKPCYVFDGKPPDLKSHELTKRSSRRVETEKKLAEATTE---LEKMKQER 126
Query: 123 RATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTP 182
R KV++ E+A+KLL LMGIP + AP+E EAQ A +A KG VYA+AS+D D+L + TP
Sbjct: 127 RLVKVSKEHNEEAQKLLGLMGIPYIIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRTP 186
Query: 183 RLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGI 242
L+R+LT + +K P +I E+ VL+ L +T E+ ++L I++G DY I
Sbjct: 187 FLLRHLTFSEAKKEPIHEIDTEL---------VLRGLDLTIEQFVDLCIMLGCDYCE-SI 236
Query: 243 KGIGPKKALEIVKY--SKDPLAKF--QRQSDVDLYAIKE---------FFLNPPTTD--D 287
+G+GP AL+++K S + + +F +S+ + I E FL+P D +
Sbjct: 237 RGVGPVTALKLIKTHGSIEKIVEFIESGESNNTKWKIPEDWPYKQARMLFLDPEVIDGNE 296
Query: 288 YSLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
+LKW P E+ +I +LCD+ FSEERVK+G+ RLKK +K+G Q L+ +F
Sbjct: 297 INLKWSPPKEKELIEYLCDDKKFSEERVKSGISRLKKGLKSGIQGRLDGFF 347
>gi|6679771 flap structure specific endonuclease 1 [Mus musculus]
>gi|729476|sp|P39749|FEN1_MOUSE FLAP ENDONUCLEASE-1
>gi|1083325|pir||A53730 flap endonuclease 1 - mouse
>gi|499649|gb|AAC37664.1| (L26320) endonuclease-1 [Mus
musculus]
Length = 378
Score = 249 bits (628), Expect = 5e-65
Identities = 142/338 (42%), Positives = 210/338 (62%), Gaps = 25/338 (7%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
+E ++++ +G+K+AIDA +IYQFL +RQ G L + +G TS L G+FYRTI ME
Sbjct: 19 RENDIKSYFGRKVAIDASMSIYQFLIAVRQ-GGDVLQNEEGETTS-LMGMFYRTIR-MEN 75
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKPVYVFDGKPP K EL KR E R EAE + ++A G EE K+ +R KV +
Sbjct: 76 GIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQEAGMEEEVEKFTKRLVKVTKQH 135
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
++ K LL LMGIP + APSE EA A +A G VYA+A++D D L FG+P L+R+LT +
Sbjct: 136 NDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSPVLMRHLTAS 195
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+K+P ++ + L VL+EL + +E+ ++L IL+G+DY I+GIG K+A+
Sbjct: 196 EAKKLPIQEFH---------LSRVLQELGLNQEQFVDLCILLGSDYCE-SIRGIGAKRAV 245
Query: 252 EIVKYSKDPLAKFQRQSDVDLYAIKE---------FFLNPPTTDDYS--LKWKEPDEEGI 300
++++ K + + R+ D Y + E FL P D S LKW EP+EE +
Sbjct: 246 DLIQKHKS-IEEIVRRLDPSKYPVPENWLHKEAQQLFLEPEVVDPESVELKWSEPNEEEL 304
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
++F+C E FSEER+++G++RL K+ + Q L+ +F
Sbjct: 305 VKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFF 342
>sp|P39750|RAD2_SCHPO DNA REPAIR PROTEIN RAD2 >gi|1362231|pir||A56054 DNA repair
endonuclease rad2 - fission yeast (Schizosaccharomyces
pombe) >gi|2408077|emb|CAB16282.1| (Z99167) dna repair
protein Rad2p [Schizosaccharomyces pombe]
>gi|4456854|emb|CAB36991.1| (X77041) RAD2 protein
[Schizosaccharomyces pombe]
Length = 380
Score = 248 bits (627), Expect = 6e-65
Identities = 138/338 (40%), Positives = 205/338 (59%), Gaps = 22/338 (6%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
K +++N +G+K+AIDA ++YQFL +R +DG LM+ +G TSHL G+FYRT+ +++
Sbjct: 19 KHNDIKNYFGRKVAIDASMSLYQFLIQVRSQDGQQLMNEQGETTSHLMGMFYRTLRIVDN 78
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKP +VFDGKPP K EL KR ++A +E G E ++A+R KV
Sbjct: 79 GIKPCFVFDGKPPTLKSGELAKRVARHQKAREDQEETKEVGTAEMVDRFAKRTVKVTRQH 138
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
++AK+LL+LMGIP V AP E EAQ A +A G VYA+AS+D D+L F P L+R+LT +
Sbjct: 139 NDEAKRLLELMGIPFVNAPCEAEAQCAALARSGKVYAAASEDMDTLCFQAPVLLRHLTFS 198
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+RK P + + E+ L L ++ E+ ++L IL+G DY I+G+GP +A+
Sbjct: 199 EQRKEPISEYNI---------EKALNGLDMSVEQFVDLCILLGCDYCE-PIRGVGPARAV 248
Query: 252 EIVKYSKDPLAKFQRQSDVDLYAIKE---------FFLNPPTT--DDYSLKWKEPDEEGI 300
E+++ L +F +++D Y I E FL+ ++ LKWK PD +GI
Sbjct: 249 ELIR-QYGTLDRFVKEADRSKYPIPEDWPYEDARRLFLDAEVLPGEEIELKWKSPDADGI 307
Query: 301 IRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
I+FL E F+E+RVK G+ RL+KA K Q L+S+F
Sbjct: 308 IQFLVKEKGFNEDRVKLGINRLEKASKTIPQGRLDSFF 345
>dbj|BAA36171.1| (AB021666) FEN-1 [Oryza sativa]
Length = 380
Score = 245 bits (619), Expect = 5e-64
Identities = 139/339 (41%), Positives = 202/339 (59%), Gaps = 25/339 (7%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
KE + E+ +G++IA+DA +IYQFL + + L + G +TSHL G+F RTI L+EA
Sbjct: 19 KEQKFESYFGRRIAVDASMSIYQFLIVVGRTGMETLTNEAGEVTSHLQGMFNRTIRLLEA 78
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
GIKPVYVFDGKPP KK+EL KR RE+A + EA+ +GD + K+++R KV +
Sbjct: 79 GIKPVYVFDGKPPDLKKQELAKRYSKREDATKELTEAVEEGDKDAIEKFSKRTVKVTKQH 138
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
E+ K+LL+LMG+P+V+AP E EA+ A + VYA AS+D DSL FG PR +R+L
Sbjct: 139 NEECKRLLRLMGVPVVEAPCEAEAECAALCINDMVYAVASEDMDSLTFGAPRFLRHLMDP 198
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
+K+P + V +VL+EL++T ++ I+L IL G DY IKGIG + AL
Sbjct: 199 SSKKIPVMEFEV---------AKVLEELELTMDQFIDLCILSGCDY-CDSIKGIGGQTAL 248
Query: 252 EIVK-----------YSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDY-SLKWKEPDEEG 299
++++ +KD ++Q D + F P T D LKW PDEEG
Sbjct: 249 KLIRQHGSIESILENINKD---RYQIPEDWPYQEARRLFKEPNVTLDIPELKWNAPDEEG 305
Query: 300 IIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
++ FL E+ F+++RV +E++K A Q LES+F
Sbjct: 306 LVEFLVKENGFNQDRVTKAIEKIKFAKNKSSQGRLESFF 344
>emb|CAB62862.1| (AL035475) putative flap exonuclease [Plasmodium falciparum]
Length = 672
Score = 227 bits (572), Expect = 2e-58
Identities = 139/343 (40%), Positives = 199/343 (57%), Gaps = 20/343 (5%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTP-LMDSKGRITSHLSGLFYRTINLME 70
KEI++E+L G+ IAIDA ++YQF+ IR + L + G TSH+SGL R+I LME
Sbjct: 19 KEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLME 78
Query: 71 AGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEM 130
G+KP+YVFDG PP K ELEKR E R++AE K+A +G++EE +K + R +V
Sbjct: 79 NGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRK 138
Query: 131 LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTI 190
E+AKKLL LMGIPI++AP E E+Q A++ +A+A++D D+L+FGT L+RNL
Sbjct: 139 QNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNA 198
Query: 191 T-----GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGI 245
K K K Y+ + I LE+VLK L +T ++ I+ IL G DY IKGI
Sbjct: 199 NATSNQNKNKNNSKRGYILTE---INLEQVLKGLNLTMDEFIDFCILCGCDY-CDTIKGI 254
Query: 246 GPKKALEIVK--------YSKDPLAKFQRQSDVDLYAIKEFFLNPPT--TDDYSLKWKEP 295
G K A ++K K+Q S+ ++ F+NP +D + W EP
Sbjct: 255 GSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEP 314
Query: 296 DEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
E + FL +++F+E RV N + RL KA K Q L+++F
Sbjct: 315 QIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFF 357
>gb|AAG01445.1| (AF278764) flap endonuclease-1 [Plasmodium falciparum]
Length = 650
Score = 227 bits (572), Expect = 2e-58
Identities = 139/343 (40%), Positives = 199/343 (57%), Gaps = 20/343 (5%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTP-LMDSKGRITSHLSGLFYRTINLME 70
KEI++E+L G+ IAIDA ++YQF+ IR + L + G TSH+SGL R+I LME
Sbjct: 19 KEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLME 78
Query: 71 AGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEM 130
G+KP+YVFDG PP K ELEKR E R++AE K+A +G++EE +K + R +V
Sbjct: 79 NGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRK 138
Query: 131 LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTI 190
E+AKKLL LMGIPI++AP E E+Q A++ +A+A++D D+L+FGT L+RNL
Sbjct: 139 QNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNA 198
Query: 191 T-----GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGI 245
K K K Y+ + I LE+VLK L +T ++ I+ IL G DY IKGI
Sbjct: 199 NATSNQNKNKNNSKRGYILTE---INLEQVLKGLNLTMDEFIDFCILCGCDY-CDTIKGI 254
Query: 246 GPKKALEIVK--------YSKDPLAKFQRQSDVDLYAIKEFFLNPPT--TDDYSLKWKEP 295
G K A ++K K+Q S+ ++ F+NP +D + W EP
Sbjct: 255 GSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEP 314
Query: 296 DEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESWF 338
E + FL +++F+E RV N + RL KA K Q L+++F
Sbjct: 315 QIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFF 357
>pir||T01198 endonuclease homolog F21E10.3 - Arabidopsis thaliana
>gi|3047083|gb|AAC13596.1| (AF058914) similar to FLAP
endonuclease-1 (SW:P39748) [Arabidopsis thaliana]
Length = 362
Score = 197 bits (496), Expect = 1e-49
Identities = 124/348 (35%), Positives = 184/348 (52%), Gaps = 54/348 (15%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFL-----STIRQRDGTPLMDSKGRITS---------- 56
KE + E+ +G+KIA+DA +IYQFL S + + L S ++
Sbjct: 19 KEQKFESYFGRKIAVDASMSIYQFLVRAPSSPLLLLEELGLKCSLMKLVKSLVWIFLCDV 78
Query: 57 ------------------HLSGLFYRTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAR 98
HL G+F RTI L+EAGIKPVYVFDGKPP K++EL KR R
Sbjct: 79 LCLYVFFVYVVIYMMFNRHLQGMFNRTIRLLEAGIKPVYVFDGKPPELKRQELAKRYSKR 138
Query: 99 EEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAA 158
+A A+ G+ E+ KY++R KV + +D K+LL+LMG+P+V+A SE EAQ A
Sbjct: 139 ADATADLTGAIEAGNKEDIEKYSKRTVKVTKQHNDDCKRLLRLMGVPVVEATSEAEAQCA 198
Query: 159 YMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKE 218
+ G VY AS+D DSL FG P+ +R+L RK+P + V ++L+E
Sbjct: 199 ALCKSGKVYGVASEDMDSLTFGAPKFLRHLMDPSSRKIPVMEFEV---------AKILEE 249
Query: 219 LKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKD--------PLAKFQRQSDV 270
L++T ++ I+L IL G DY I+GIG + AL++++ ++Q +
Sbjct: 250 LQLTMDQFIDLCILSGCDY-CDSIRGIGGQTALKLIRQHGSIETILENLNKERYQIPEEW 308
Query: 271 DLYAIKEFFLNPPTTDD---YSLKWKEPDEEGIIRFLCDEHDFSEERV 315
++ F P D +KW PDEEGI++FL +E+ F+ +RV
Sbjct: 309 PYNEARKLFKEPDVITDEEQLDIKWTSPDEEGIVQFLVNENGFNIDRV 356
>gb|AAG19690.1| (AE005056) DNA repair protein; Rad2 [Halobacterium sp. NRC-1]
Length = 327
Score = 164 bits (412), Expect = 1e-39
Identities = 116/339 (34%), Positives = 169/339 (49%), Gaps = 28/339 (8%)
Query: 7 ELIPRKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMD-SKGRITSHLSGLFYRT 65
+L +E +L G +A+DA N +Y++L+T Q G + S G ++L G
Sbjct: 8 QLAAIEETPFADLEGSVVAVDAHNWLYKYLTTTVQWTGADVYTTSDGTEVANLVGAVQGL 67
Query: 66 INLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRAT 125
E G+ PV+V+DG K E+ RRE RE E + +A GD EA + R
Sbjct: 68 PKFFEHGLTPVFVWDGGVTELKDDEIADRREQRERYEEQLDDAREAGDAAEAARLDARTQ 127
Query: 126 KVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGD-VYASASQDYDSLLFGTPRL 184
++ + E ++L L+ IP V+AP+EGEAQAAYM D V + S DYD LL G+P
Sbjct: 128 RLTPTIHETTRELFDLLDIPQVEAPAEGEAQAAYMTRTDDAVDYAGSDDYDCLLLGSPVT 187
Query: 185 VRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKG 244
+R LT +G PEL+ + L E +T E+L+++ IL GTD+NP GI G
Sbjct: 188 LRQLTSSG-------------HPELMDFDATLAEHDLTWEQLVDVGILCGTDFNP-GIDG 233
Query: 245 IGPKKALEIVKYSKDPLAKFQRQSDVDLYA--IKEFFLNPPTTDDYSLKWKEPDEEGII- 301
GP AL+ + D + + + I+E FLNP TDDY + +PD I
Sbjct: 234 FGPTTALDAIGEHGDLWDVLAAEGEHVAHGDRIRELFLNPDVTDDYVI---DPDVSPAID 290
Query: 302 ---RFLCDEHDFSEERVKNGLERLKKAIKAGKQSTLESW 337
F+ DE + + V G ER+ A Q+ L+ W
Sbjct: 291 AARAFVTDEWEVDADAVARGFERID---AAAAQTGLDRW 326
>gb|AAD46833.1|AF160893_1 (AF160893) BcDNA.GM10765 [Drosophila melanogaster]
Length = 726
Score = 94.4 bits (231), Expect = 2e-18
Identities = 72/258 (27%), Positives = 116/258 (44%), Gaps = 23/258 (8%)
Query: 6 GELIPRKEIE-LENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYR 64
G L P E + + L GKK+AID + + L+ + D HL LF+R
Sbjct: 8 GVLTPHCERKPINELRGKKVAIDLAGWVCESLNVV---------DYFVHPRHHLKNLFFR 58
Query: 65 TINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRA 124
T L+ + PV+V +G P K + + KR E ++++ K E + +
Sbjct: 59 TCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNE------LQFRGVKPKNSPECTQSQPSKG 112
Query: 125 TKVNEM---LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGT 181
K +++ + LL MGI VQ P E EA A++ G V SQD D +G
Sbjct: 113 DKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGA 172
Query: 182 PRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGG 241
R+ RN +++ + V+I + E+ + ++K+I +A+L G DY P G
Sbjct: 173 VRVYRNFSVSTQGAQAAAGGAVDIYD----MREITSRMDFGQQKIIVMALLCGCDYCPDG 228
Query: 242 IKGIGPKKALEIVKYSKD 259
I GIG L++ K+
Sbjct: 229 IGGIGKDGVLKLFNKYKE 246
>gb|AAF50805.1| (AE003567) BcDNA:GM10765 gene product [Drosophila melanogaster]
Length = 726
Score = 94.4 bits (231), Expect = 2e-18
Identities = 72/258 (27%), Positives = 116/258 (44%), Gaps = 23/258 (8%)
Query: 6 GELIPRKEIE-LENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYR 64
G L P E + + L GKK+AID + + L+ + D HL LF+R
Sbjct: 8 GVLTPHCERKPINELRGKKVAIDLAGWVCESLNVV---------DYFVHPRHHLKNLFFR 58
Query: 65 TINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRA 124
T L+ + PV+V +G P K + + KR E ++++ K E + +
Sbjct: 59 TCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNE------LQFRGVKPKNSPECTQSQPSKG 112
Query: 125 TKVNEM---LIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGT 181
K +++ + LL MGI VQ P E EA A++ G V SQD D +G
Sbjct: 113 DKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGA 172
Query: 182 PRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGG 241
R+ RN +++ + V+I + E+ + ++K+I +A+L G DY P G
Sbjct: 173 VRVYRNFSVSTQGAQAAAGGAVDIYD----MREITSRMDFGQQKIIVMALLCGCDYCPDG 228
Query: 242 IKGIGPKKALEIVKYSKD 259
I GIG L++ K+
Sbjct: 229 IGGIGKDGVLKLFNKYKE 246
>gb|AAC33874.1| (AF060479) exonuclease I [Homo sapiens]
Length = 800
Score = 89.3 bits (218), Expect = 6e-17
Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)
Query: 50 SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
+KG T G + +N L+ GIKP+ VFDG KK+ RRE R+ +K K+
Sbjct: 47 AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106
Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
L +G + EAR+ R+ + + K + G+ + AP E +AQ AY+ G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166
Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
++D D L FG +++ + G +EI + + L ++ T EK
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217
Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
+ IL G DY ++GIG KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248
>gi|11426418 exonuclease 1 [Homo sapiens] >gi|3822433|gb|AAC69879.1| (AF091754)
exonuclease Ib [Homo sapiens]
Length = 846
Score = 89.3 bits (218), Expect = 6e-17
Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)
Query: 50 SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
+KG T G + +N L+ GIKP+ VFDG KK+ RRE R+ +K K+
Sbjct: 47 AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106
Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
L +G + EAR+ R+ + + K + G+ + AP E +AQ AY+ G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166
Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
++D D L FG +++ + G +EI + + L ++ T EK
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217
Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
+ IL G DY ++GIG KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248
>gi|10835226 exonuclease 1; rad2 nuclease family member, homolog of S.
cerevisiae exonuclease 1 [Homo sapiens]
>gi|4249655|gb|AAD13754.1| (AF084974) exonuclease I
[Homo sapiens]
Length = 846
Score = 89.3 bits (218), Expect = 6e-17
Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)
Query: 50 SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
+KG T G + +N L+ GIKP+ VFDG KK+ RRE R+ +K K+
Sbjct: 47 AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106
Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
L +G + EAR+ R+ + + K + G+ + AP E +AQ AY+ G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166
Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
++D D L FG +++ + G +EI + + L ++ T EK
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217
Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
+ IL G DY ++GIG KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248
>gi|11426420 Rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
[Homo sapiens] >gi|3445182|gb|AAC32424.1| (AC004783)
Hex1 [Homo sapiens] >gi|3822434|gb|AAC69880.1|
(AF091754) exonuclease Ia [Homo sapiens]
Length = 803
Score = 89.3 bits (218), Expect = 6e-17
Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)
Query: 50 SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
+KG T G + +N L+ GIKP+ VFDG KK+ RRE R+ +K K+
Sbjct: 47 AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106
Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
L +G + EAR+ R+ + + K + G+ + AP E +AQ AY+ G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166
Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
++D D L FG +++ + G +EI + + L ++ T EK
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217
Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
+ IL G DY ++GIG KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248
>gi|6753788 exonuclease 1 [Mus musculus] >gi|5689874|emb|CAB51863.1| (AJ238213)
exonuclease 1 homologue [Mus musculus]
Length = 837
Score = 89.3 bits (218), Expect = 6e-17
Identities = 60/212 (28%), Positives = 104/212 (48%), Gaps = 11/212 (5%)
Query: 50 SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
+KG T G + +N L+ G+KP+ +FDG KK+ RRE R+ +K K+
Sbjct: 47 AKGEPTDRYVGFCMKFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQL 106
Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
L +G + EAR R+ + + K + +G+ + AP E +AQ AY+ G V A
Sbjct: 107 LREGKVSEARDCFARSINITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQA 166
Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
++D D L FG +++ + G +E+ + + + L ++ T EK
Sbjct: 167 VITEDSDLLAFGCKKVILKMDQFGNG--------LEVDQARLGMCKQLGDV-FTEEKFRY 217
Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
+ IL G DY ++GIG KA ++++ + +P
Sbjct: 218 MCILSGCDY-LASLRGIGLAKACKVLRLANNP 248
>gi|4504369 exonuclease 1; rad2 nuclease family member, homolog of S.
cerevisiae exonuclease 1 [Homo sapiens]
>gi|3170238|gb|AAC32259.1| (AF042282) Hex1 [Homo
sapiens] >gi|3703096|gb|AAC63043.1| (AF091740)
exonuclease 1a [Homo sapiens]
Length = 803
Score = 89.3 bits (218), Expect = 6e-17
Identities = 63/212 (29%), Positives = 103/212 (47%), Gaps = 11/212 (5%)
Query: 50 SKGRITSHLSGLFYRTIN-LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEA 108
+KG T G + +N L+ GIKP+ VFDG KK+ RRE R+ +K K+
Sbjct: 47 AKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQL 106
Query: 109 LAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYA 168
L +G + EAR+ R+ + + K + G+ + AP E +AQ AY+ G V A
Sbjct: 107 LREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQA 166
Query: 169 SASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIE 228
++D D L FG +++ + G +EI + + L ++ T EK
Sbjct: 167 IITEDSDLLAFGCKKVILKMDQFGNG--------LEIDQARLGMCRQLGDV-FTEEKFRY 217
Query: 229 LAILVGTDYNPGGIKGIGPKKALEIVKYSKDP 260
+ IL G DY ++GIG KA ++++ + +P
Sbjct: 218 MCILSGCDY-LSSLRGIGLAKACKVLRLANNP 248
>gb|AAF76467.1|AC020622_1 (AC020622) Contains similarity to excision repair protein ERCC5
from Homo sapiens gi|1082359 and contains XPG N-terminal
PF|00752 and XPG I-region PF|00867 domains. [Arabidopsis
thaliana]
Length = 497
Score = 84.3 bits (205), Expect = 2e-15
Identities = 64/216 (29%), Positives = 103/216 (47%), Gaps = 22/216 (10%)
Query: 57 HLSGLFYRTINLMEA-GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIE 115
HL F+RTINL G PV+V DG P K + R R + K +
Sbjct: 51 HLRLTFFRTINLFSKFGAYPVFVVDGTPSPLKS-QARISRFFRSSGIDTCNLPVIKDGVS 109
Query: 116 EARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYD 175
R K+ + + +LL+L+GIP+++A E EA A + +G V A + D D
Sbjct: 110 VERN------KLFSEWVRECVELLELLGIPVLKANGEAEALCAQLNSQGFVDACITPDSD 163
Query: 176 SLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGT 235
+ LFG +++++ + E + + L + R+ LI +++LVG
Sbjct: 164 AFLFGAMCVIKDIKPNSREPF-----------ECYHMSHIESGLGLKRKHLIAISLLVGN 212
Query: 236 DYNPGGIKGIGPKKALEIVK-YSKDPLAKFQRQSDV 270
DY+ GG+ GIG KAL IV+ +S+D + +R D+
Sbjct: 213 DYDSGGVLGIGVDKALRIVREFSEDQV--LERLQDI 246
>pir||E71619 RAD2 endonuclease PFB0265c - malaria parasite (Plasmodium falciparum)
>gi|3845138|gb|AAC71842.1| (AE001383) RAD2 endonuclease
[Plasmodium falciparum]
Length = 1516
Score = 80.4 bits (195), Expect = 3e-14
Identities = 75/265 (28%), Positives = 120/265 (44%), Gaps = 53/265 (20%)
Query: 114 IEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQD 173
I+E +K + ++N+ + +D K LL GIP +Q+P E EAQ +Y+ K A S D
Sbjct: 1194 IKEYKKLKKNNIEINDEMNDDIKLLLNFFGIPYIQSPCEAEAQCSYLNNKNYCDAIISDD 1253
Query: 174 YDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILV 233
D L+F +++N K+K VE+ + + E +L + +E+LI +++L
Sbjct: 1254 SDVLVFSGKTVIKN--FFNKKKT------VEVYEKKAIEE----KLGLYQEELINISLLC 1301
Query: 234 GTDYNPGGIKGIGPKKALEIV---------KYSKDPLAKFQRQSDVDLY--AIKEF---- 278
G DY G+ GIG ALEI+ K KD ++ R+ D ++Y I++F
Sbjct: 1302 GCDYTI-GVHGIGIVNALEIIKAFPNFEDLKILKDIVSNPFRKIDKNMYNEEIQQFLNTH 1360
Query: 279 ---------------------FLNPPT-TDDYSLKWKEPDEEGIIRFLCDEHDFSEERVK 316
F P TD +W PD + I +FL + SEE+V
Sbjct: 1361 KNYKLNWIFPNNFPDREVYKCFKYPKVCTDIKKFEWHVPDIKSITKFLHKTTNISEEKVL 1420
Query: 317 NGLERLKKAIKAG---KQSTLESWF 338
N L + + QS +E +F
Sbjct: 1421 NVLNPILQKYNVNVRTYQSKIEDFF 1445
>gb|AAD31867.1|AF134570_1 (AF134570) exonuclease ExoI [Xenopus laevis]
Length = 734
Score = 79.2 bits (192), Expect = 6e-14
Identities = 57/193 (29%), Positives = 92/193 (47%), Gaps = 10/193 (5%)
Query: 68 LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKV 127
L+ G+KP+ VFDG KK + RRE R+ K K+ L +G + EAR+ R+ +
Sbjct: 66 LLSFGVKPILVFDGCTLPSKKDVEKARREKRQTNLQKGKQLLREGKLAEARECFSRSVNI 125
Query: 128 NEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRN 187
+ + K + G+ + AP E ++Q AY+ A ++D D L FG +++
Sbjct: 126 TSSMAHEVIKAARSEGVDYIVAPYEADSQLAYLNKNDFAEAIITEDSDLLAFGCKKVLLK 185
Query: 188 LTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGP 247
+ G +EI + L ++ T EK + IL G DY P I GIG
Sbjct: 186 MDKFGNG--------LEIDQARFGMCRSLGDV-FTEEKFRYMCILSGCDYLP-SIHGIGL 235
Query: 248 KKALEIVKYSKDP 260
KA +++K + +P
Sbjct: 236 AKACKLLKVANNP 248
>sp|P28706|RA13_SCHPO DNA REPAIR PROTEIN RAD13 >gi|422055|pir||S30301 excision repair
protein - fission yeast (Schizosaccharomyces pombe)
>gi|5020|emb|CAA47291.1| (X66795) excision repair
protein [Schizosaccharomyces pombe]
Length = 1113
Score = 76.9 bits (186), Expect = 3e-13
Identities = 74/288 (25%), Positives = 127/288 (43%), Gaps = 52/288 (18%)
Query: 90 ELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQA 149
EL +R E E + +++ L + + + A +V +++I++ ++LL+L G+P + A
Sbjct: 716 ELNQRHETEEWNQEAFEKRLKEAQKSKKGSEKRDADEVTQVMIKECQELLRLFGLPYIVA 775
Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
P E EAQ + + V + D D LFG R+ RN+ K +V EL
Sbjct: 776 PQEAEAQCSKLLELKLVDGIVTDDSDVFLFGGTRVYRNMFNQNK--------FV----EL 823
Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKDPLAKFQ---- 265
+++++ +E + + LI+LA L+G+DY G+ +GP ALEI+ F+
Sbjct: 824 YLMDDMKREFNVNQMDLIKLAHLLGSDYTM-GLSRVGPVLALEILHEFPGDTGLFEFKKW 882
Query: 266 ---------RQSDVDLYAIKEF------------FLNP--------PTTDD--YSLKWKE 294
++DV+ K F NP P DD S +W
Sbjct: 883 FQRLSTGHASKNDVNTPVKKRINKLVGKIILPSEFPNPLVDEAYLHPAVDDSKQSFQWGI 942
Query: 295 PDEEGIIRFLCDEHDFSEERVKNGL----ERLKKAIKAGKQSTLESWF 338
PD + + +FL +S++R L + + K G QS L +F
Sbjct: 943 PDLDELRQFLMATVGWSKQRTNEVLLPVIQDMHKKQFVGTQSNLTQFF 990
Score = 73.4 bits (177), Expect = 4e-12
Identities = 37/92 (40%), Positives = 57/92 (61%), Gaps = 6/92 (6%)
Query: 11 RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLME 70
++ ++LE L K++AIDA IYQFL +R ++G L +SH+ G F R L+
Sbjct: 14 KRPVKLETLVNKRLAIDASIWIYQFLKAVRDKEGNQLK------SSHVVGFFRRICKLLF 67
Query: 71 AGIKPVYVFDGKPPAFKKKELEKRREAREEAE 102
GIKPV+VFDG P+ K++ ++KR+ R + E
Sbjct: 68 FGIKPVFVFDGGAPSLKRQTIQKRQARRLDRE 99
>gb|AAG12649.1|AC068667_30 (AC068667) exonuclease, putative; 92014-93872 [Arabidopsis
thaliana]
Length = 317
Score = 76.1 bits (184), Expect = 5e-13
Identities = 77/300 (25%), Positives = 134/300 (44%), Gaps = 21/300 (7%)
Query: 14 IELENLYGKKIAIDALNAIYQ-FLSTIRQRDGTPLMDSKGRITS-HLSGLFYRTINLMEA 71
I ++ L G +A+D + +++ LS R+ KG T H+ +R L
Sbjct: 17 IHIKELEGCIVAVDTYSWLHKGALSCSREL-------CKGLPTKRHIQYCMHRVNLLRHH 69
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEML 131
G+KP+ VFDG P K ++ KR +R+E + E A G+ A + +A ++ +
Sbjct: 70 GVKPIMVFDGGPLPMKLEQENKRARSRKENLARALEHEANGNSSAAYECYSKAVDISPSI 129
Query: 132 IEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTIT 191
+ ++L+ + V AP E +AQ A++A V A ++D D + FG R++ +
Sbjct: 130 AHELIQVLRQENVDYVVAPYEADAQMAFLAITKQVDAIITEDSDLIPFGCLRIIFKMDKF 189
Query: 192 GKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKAL 251
G VE + + + L + + L+E+ IL G DY + G+G K+A
Sbjct: 190 GHG--------VEFQASKLPKNKDLSLSGFSSQMLLEMCILSGCDYLQ-SLPGMGLKRAH 240
Query: 252 EIVKYSK--DPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDEHD 309
++ K D + K + S V + + E + +P+ E II LCD D
Sbjct: 241 ALITKFKSYDRVIKHLKYSTVSVPPLYEESFKRALLTFKHQRVYDPNAEDIIH-LCDISD 299
>gi|6320469 involved in DNA repair; Din7p [Saccharomyces cerevisiae]
>gi|2501673|sp|Q12086|DIN7_YEAST DNA-DAMAGE INDUCIBLE
PROTEIN DIN7 >gi|2131229|pir||S61118 DIN7 protein -
yeast (Saccharomyces cerevisiae)
>gi|1134889|emb|CAA92581.1| (Z68290) unknown
[Saccharomyces cerevisiae] >gi|1143552|emb|CAA62233.1|
(X90707) DIN7 protein [Saccharomyces cerevisiae]
>gi|1226039|emb|CAA94102.1| (Z70202) Din7p
[Saccharomyces cerevisiae]
Length = 430
Score = 75.7 bits (183), Expect = 7e-13
Identities = 78/275 (28%), Positives = 125/275 (45%), Gaps = 25/275 (9%)
Query: 1 MGVPIGELIPR-----KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRIT 55
MG+P L+P+ K++ L+ + +AID Y +L L+ +K T
Sbjct: 1 MGIP--GLLPQLKRIQKQVSLKKYMYQTLAIDG----YAWLHRASCACAFELVMNKP--T 52
Query: 56 SHLSGLFYRTINLMEA-GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDI 114
+ F + + L++ IKP VFDG K +RR+ R E E+ K+ + G+
Sbjct: 53 NKYLQFFIKRLQLLKRLKIKPYIVFDGDSLFVKNHTETRRRKKRLENEMIAKKLWSAGNR 112
Query: 115 EEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDY 174
A +Y Q++ + + + +L IP + AP E + Q Y+ G + S+D
Sbjct: 113 YNAMEYFQKSVDITPEMAKCIIDYCKLHSIPYIVAPFEADPQMVYLEKMGLIQGIISEDS 172
Query: 175 DSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVG 234
D L+FG L+ L GK KD + + PE L E ++ ++ L L G
Sbjct: 173 DLLVFGCKTLITKLNDQGKALEISKDDFSAL-PENFPLGE------LSEQQFRNLVCLAG 225
Query: 235 TDYNPGGIKGIGPKKALEIVK-YS--KDPLAKFQR 266
DY GI +G A++IVK YS KD L + +R
Sbjct: 226 CDYT-SGIWKVGVVTAMKIVKRYSEMKDILIQIER 259
>pir||T40382 dna repair protein rad13 - fission yeast (Schizosaccharomyces
pombe) >gi|3130034|emb|CAA19011.1| (AL023534) dna repair
protein rad13 [Schizosaccharomyces pombe]
Length = 1112
Score = 74.9 bits (181), Expect = 1e-12
Identities = 76/288 (26%), Positives = 128/288 (44%), Gaps = 53/288 (18%)
Query: 90 ELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQA 149
EL +R E E + +++ L K + R + A +V +++I++ ++LL+L G+P + A
Sbjct: 716 ELNQRHETEEWNQEAFEKRL-KELKNQKRSEKRDADEVTQVMIKECQELLRLFGLPYIVA 774
Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
P E EAQ + + V + D D LFG R+ RN+ K +V EL
Sbjct: 775 PQEAEAQCSKLLELKLVDGIVTDDSDVFLFGGTRVYRNMFNQNK--------FV----EL 822
Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEIVKYSKDPLAKFQ---- 265
+++++ +E + + LI+LA L+G+DY G+ +GP ALEI+ F+
Sbjct: 823 YLMDDMKREFNVNQMDLIKLAHLLGSDYTM-GLSRVGPVLALEILHEFPGDTGLFEFKKW 881
Query: 266 ---------RQSDVDLYAIKEF------------FLNP--------PTTDD--YSLKWKE 294
++DV+ K F NP P DD S +W
Sbjct: 882 FQRLSTGHASKNDVNTPVKKRINKLVGKIILPSEFPNPLVDEAYLHPAVDDSKQSFQWGI 941
Query: 295 PDEEGIIRFLCDEHDFSEERVKNGL----ERLKKAIKAGKQSTLESWF 338
PD + + +FL +S++R L + + K G QS L +F
Sbjct: 942 PDLDELRQFLMATVGWSKQRTNEVLLPVIQDMHKKQFVGTQSNLTQFF 989
Score = 73.4 bits (177), Expect = 4e-12
Identities = 37/92 (40%), Positives = 57/92 (61%), Gaps = 6/92 (6%)
Query: 11 RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLME 70
++ ++LE L K++AIDA IYQFL +R ++G L +SH+ G F R L+
Sbjct: 14 KRPVKLETLVNKRLAIDASIWIYQFLKAVRDKEGNQLK------SSHVVGFFRRICKLLF 67
Query: 71 AGIKPVYVFDGKPPAFKKKELEKRREAREEAE 102
GIKPV+VFDG P+ K++ ++KR+ R + E
Sbjct: 68 FGIKPVFVFDGGAPSLKRQTIQKRQARRLDRE 99
>sp|P53695|EXO1_SCHPO EXONUCLEASE I (EXO I) >gi|7490548|pir||T40060 exonuclease i -
fission yeast (Schizosaccharomyces pombe)
>gi|11359238|pir||T43288 probable exodeoxyribonuclease I
(EC 3.1.11.1) - fission yeast (Schizosaccharomyces
pombe) >gi|703466|gb|AAC41648.1| (L35174) exonuclease
[Schizosaccharomyces pombe] >gi|4007793|emb|CAA22433.1|
(AL034463) exonuclease i [Schizosaccharomyces pombe]
Length = 571
Score = 73.7 bits (178), Expect = 3e-12
Identities = 68/259 (26%), Positives = 113/259 (43%), Gaps = 16/259 (6%)
Query: 5 IGELIP-RKEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFY 63
+G L P +K +E GK + +D +++ + T + +L +
Sbjct: 7 LGLLKPMQKSSHVEEFSGKTLGVDGYVWLHKAVFTCAHE-----LAFNKETDKYLKYAIH 61
Query: 64 RTINLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQR 123
+ + L G+KP+ VFDG P K +KR+E R+EA K+ +G +A R
Sbjct: 62 QALMLQYYGVKPLIVFDGGPLPCKASTEQKRKERRQEAFELGKKLWDEGKKSQAIMQFSR 121
Query: 124 ATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPR 183
V + L+ GI + AP E +AQ Y+ + + ++D D L+FG
Sbjct: 122 CVDVTPEMAWKLIIALREHGIESIVAPYEADAQLVYLEKENIIDGIITEDSDMLVFGAQT 181
Query: 184 LVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIK 243
++ KM G + I+ I + L L++ EKL +AI G DY G+
Sbjct: 182 VL--------FKMDGFGNCITIRRNDIANAQDL-NLRLPIEKLRHMAIFSGCDYT-DGVA 231
Query: 244 GIGPKKALEIVKYSKDPLA 262
G+G K AL ++ +P A
Sbjct: 232 GMGLKTALRYLQKYPEPRA 250
>gi|6321697 homolog of xeroderma pigmentosum group G (XPG) protein, copufurifies
with transcription factor, TFIIH, mRNA is cell cycle
regulated and induced by DNA damage and by meiosis
(different cis-sites utilized in damage and meiotic
induction; Rad2p [Saccharom>
>gi|131811|sp|P07276|RAD2_YEAST DNA REPAIR PROTEIN RAD2
>gi|83443|pir||A29839 RAD2 protein - yeast (Saccharomyces
cerevisiae) >gi|172329|gb|AAA66928.1| (M10275) RAD2
[Saccharomyces cerevisiae] >gi|1323470|emb|CAA97287.1|
(Z73043) ORF YGR258c [Saccharomyces cerevisiae]
Length = 1031
Score = 72.6 bits (175), Expect = 6e-12
Identities = 80/310 (25%), Positives = 130/310 (41%), Gaps = 60/310 (19%)
Query: 67 NLMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDI-EEARKYAQRAT 125
N++E IK FD FK L E R AE A + ++ E+ K + +
Sbjct: 715 NIVENMIKEQEEFD----TFKNTTLSTSAE-RNVAE----NAFVEDELFEQQMKDKRDSD 765
Query: 126 KVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLV 185
+V +I++ ++LL GIP + AP E EAQ A + V + D D LFG ++
Sbjct: 766 EVTMDMIKEVQELLSRFGIPYITAPMEAEAQCAELLQLNLVDGIITDDSDVFLFGGTKIY 825
Query: 186 RNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGI 245
+N M + YVE E +LK L + R+ +IELA L+G+DY G+KG+
Sbjct: 826 KN--------MFHEKNYVEFYD----AESILKLLGLDRKNMIELAQLLGSDYT-NGLKGM 872
Query: 246 GPKKALEIV---------------------------KYSKDPLAKFQR-----QSDVDLY 273
GP ++E++ K+ KD K D
Sbjct: 873 GPVSSIEVIAEFGNLKNFKDWYNNGQFDKRKQETENKFEKDLRKKLVNNEIILDDDFPSV 932
Query: 274 AIKEFFLNPPTTDDYS-LKWKEPDEEGIIRFLCDE----HDFSEERVKNGLERLKKAIKA 328
+ + ++ P D + W PD + + F+ + H+ S+E + + + K K
Sbjct: 933 MVYDAYMRPEVDHDTTPFVWGVPDLDMLRSFMKTQLGWPHEKSDEILIPLIRDVNKRKKK 992
Query: 329 GKQSTLESWF 338
GKQ + +F
Sbjct: 993 GKQKRINEFF 1002
Score = 69.5 bits (167), Expect = 5e-11
Identities = 33/88 (37%), Positives = 55/88 (62%), Gaps = 6/88 (6%)
Query: 12 KEIELENLYGKKIAIDALNAIYQFLSTIRQRDGTPLMDSKGRITSHLSGLFYRTINLMEA 71
+ + LE+L K++A+DA IYQFL +R ++G + +S H++G F R L+
Sbjct: 15 RPVRLESLEDKRMAVDASIWIYQFLKAVRDQEGNAVKNS------HITGFFRRICKLLYF 68
Query: 72 GIKPVYVFDGKPPAFKKKELEKRREARE 99
GI+PV+VFDG P K++ + +R+E R+
Sbjct: 69 GIRPVFVFDGGVPVLKRETIRQRKERRQ 96
>gi|6324607 exonuclease; Dhs1p [Saccharomyces cerevisiae]
>gi|1706421|sp|P39875|EXO1_YEAST EXONUCLEASE I (EXO I)
(DHS1 PROTEIN) >gi|2131226|pir||S62169 DHS1 protein -
yeast (Saccharomyces cerevisiae)
>gi|1041655|emb|CAA60749.1| (X87331) overlaps with
S69545. Encodes protein 219 amino acids longer than
published protein sequence [Saccharomyces cerevisiae]
>gi|1420150|emb|CAA99223.1| (Z74941) ORF YOR033c
[Saccharomyces cerevisiae] >gi|1840127|gb|AAB47428.1|
(U86134) Exo1p [Saccharomyces cerevisiae]
Length = 702
Score = 72.6 bits (175), Expect = 6e-12
Identities = 56/205 (27%), Positives = 97/205 (47%), Gaps = 9/205 (4%)
Query: 52 GRITSHLSGLFYRTINLMEA-GIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALA 110
G+ T F + +L++ ++P VFDG KK KRR+ R+E + + A
Sbjct: 49 GKPTDKYLQFFIKRFSLLKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWA 108
Query: 111 KGDIEEARKYAQRATKVNEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASA 170
G+ + A Y Q+ + + + +L GI + AP E ++Q Y+ K V
Sbjct: 109 CGEKKNAMDYFQKCVDITPEMAKCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGII 168
Query: 171 SQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELA 230
S+D D L+FG RL+ L G+ +D ++++ P+ L +T E++I +
Sbjct: 169 SEDSDLLVFGCRRLITKLNDYGECLEICRDNFIKL-PKKFPLG------SLTNEEIITMV 221
Query: 231 ILVGTDYNPGGIKGIGPKKALEIVK 255
L G DY GI +G A+++V+
Sbjct: 222 CLSGCDYT-NGIPKVGLITAMKLVR 245
>gb|AAD38375.1|AF144092_1 (AF144092) nucleotide excision repair protein MUS201 [Drosophila
melanogaster] >gi|7297419|gb|AAF52678.1| (AE003621)
mus201 gene product [alt 2] [Drosophila melanogaster]
Length = 1236
Score = 71.4 bits (172), Expect = 1e-11
Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)
Query: 91 LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
L+ ++ + E E+ A + ++E R R +++ + D ++LL+L GIP + A
Sbjct: 818 LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 877
Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
P E EAQ A++ + + + D D LFG + +N K M +
Sbjct: 878 PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 927
Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
E++ + R KLI+LA LVG+DY GI GIG ALEI
Sbjct: 928 --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGQDANGPGICN 984
Query: 254 -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
+K+ S LA ++ +++L+ A+ E +L PT
Sbjct: 985 QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1043
Query: 286 DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
DD + W PD E I F ++ + + L + K I K Q ++ ++F K
Sbjct: 1044 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1102
>gb|AAD50779.1|AF162792_1 (AF162792) XPG [Drosophila melanogaster]
Length = 1236
Score = 71.4 bits (172), Expect = 1e-11
Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)
Query: 91 LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
L+ ++ + E E+ A + ++E R R +++ + D ++LL+L GIP + A
Sbjct: 818 LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 877
Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
P E EAQ A++ + + + D D LFG + +N K M +
Sbjct: 878 PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 927
Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
E++ + R KLI+LA LVG+DY GI GIG ALEI
Sbjct: 928 --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGRDANGPGICN 984
Query: 254 -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
+K+ S LA ++ +++L+ A+ E +L PT
Sbjct: 985 QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1043
Query: 286 DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
DD + W PD E I F ++ + + L + K I K Q ++ ++F K
Sbjct: 1044 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1102
>gb|AAD50780.1|AF162793_1 (AF162793) XPG variant [Drosophila melanogaster]
Length = 1257
Score = 71.4 bits (172), Expect = 1e-11
Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)
Query: 91 LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
L+ ++ + E E+ A + ++E R R +++ + D ++LL+L GIP + A
Sbjct: 839 LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 898
Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
P E EAQ A++ + + + D D LFG + +N K M +
Sbjct: 899 PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 948
Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
E++ + R KLI+LA LVG+DY GI GIG ALEI
Sbjct: 949 --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGRDANGPGICN 1005
Query: 254 -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
+K+ S LA ++ +++L+ A+ E +L PT
Sbjct: 1006 QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1064
Query: 286 DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
DD + W PD E I F ++ + + L + K I K Q ++ ++F K
Sbjct: 1065 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1123
>gb|AAG22424.1| (AE003621) mus201 gene product [alt 1] [Drosophila melanogaster]
Length = 1257
Score = 71.4 bits (172), Expect = 1e-11
Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)
Query: 91 LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
L+ ++ + E E+ A + ++E R R +++ + D ++LL+L GIP + A
Sbjct: 839 LKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 898
Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
P E EAQ A++ + + + D D LFG + +N K M +
Sbjct: 899 PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 948
Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
E++ + R KLI+LA LVG+DY GI GIG ALEI
Sbjct: 949 --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGQDANGPGICN 1005
Query: 254 -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
+K+ S LA ++ +++L+ A+ E +L PT
Sbjct: 1006 QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1064
Query: 286 DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
DD + W PD E I F ++ + + L + K I K Q ++ ++F K
Sbjct: 1065 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1123
>gi|4503601 XPG-complementing protein; excision repair cross-complementing
rodent repair deficiency, complementation group 5;
xeroderma pigmentosum complementation group G;
Excision-repair, complementing defective, in Chinese
hamster, [Homo sapiens] >gi|267420|sp|P28715|XPG_HUMAN
DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS (XERODERMA
PIGMENTOSUM GROUP G COMPLEMENTING PROTEIN) (DNA EXCISION
REPAIR PROTEIN ERCC-5) >gi|423150|pir||S35993 DNA repair
protein XPGC - human >gi|298111|emb|CAA49598.1| (X69978)
XP-G factor [Homo sapiens]
Length = 1186
Score = 70.6 bits (170), Expect = 2e-11
Identities = 63/196 (32%), Positives = 92/196 (46%), Gaps = 25/196 (12%)
Query: 80 DGKPPAFKKKELEKRREAR----EEAEIKWKEALAKGDIEEARKYAQR---ATKVNEMLI 132
DG+P +K + E + EE E LA+ + +A+K Q AT +M +
Sbjct: 711 DGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFL 770
Query: 133 EDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITG 192
E +++LL+L GIP +QAP E EAQ A + + + D D LFG + RN
Sbjct: 771 E-SQELLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRN--FFN 827
Query: 193 KRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALE 252
K K YV+ +L + R KLI LA L+G+DY GI +G A+E
Sbjct: 828 KNKFVEYYQYVDFH----------NQLGLDRNKLINLAYLLGSDYTE-GIPTVGCVTAME 876
Query: 253 IVK----YSKDPLAKF 264
I+ + +PL KF
Sbjct: 877 ILNEFPGHGLEPLLKF 892
>pir||A54439 excision repair protein ERCC5 - human >gi|306742|gb|AAC37533.1|
(L20046) excision repair protein [Homo sapiens]
Length = 1186
Score = 70.6 bits (170), Expect = 2e-11
Identities = 63/196 (32%), Positives = 92/196 (46%), Gaps = 25/196 (12%)
Query: 80 DGKPPAFKKKELEKRREAR----EEAEIKWKEALAKGDIEEARKYAQR---ATKVNEMLI 132
DG+P +K + E + EE E LA+ + +A+K Q AT +M +
Sbjct: 711 DGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFL 770
Query: 133 EDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITG 192
E +++LL+L GIP +QAP E EAQ A + + + D D LFG + RN
Sbjct: 771 E-SQELLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRN--FFN 827
Query: 193 KRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALE 252
K K YV+ +L + R KLI LA L+G+DY GI +G A+E
Sbjct: 828 KNKFVEYYQYVDFH----------NQLGLDRNKLINLAYLLGSDYTE-GIPTVGCVTAME 876
Query: 253 IVK----YSKDPLAKF 264
I+ + +PL KF
Sbjct: 877 ILNEFPGHGLEPLLKF 892
>gb|AAF89179.1| (AF255442) xeroderma pigmentosum complementation group G protein
splice variant [Homo sapiens]
Length = 1186
Score = 70.6 bits (170), Expect = 2e-11
Identities = 63/196 (32%), Positives = 92/196 (46%), Gaps = 25/196 (12%)
Query: 80 DGKPPAFKKKELEKRREAR----EEAEIKWKEALAKGDIEEARKYAQR---ATKVNEMLI 132
DG+P +K + E + EE E LA+ + +A+K Q AT +M +
Sbjct: 711 DGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFL 770
Query: 133 EDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITG 192
E +++LL+L GIP +QAP E EAQ A + + + D D LFG + RN
Sbjct: 771 E-SQELLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRN--FFN 827
Query: 193 KRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALE 252
K K YV+ +L + R KLI LA L+G+DY GI +G A+E
Sbjct: 828 KNKFVEYYQYVDFH----------NQLGLDRNKLINLAYLLGSDYTE-GIPTVGCVTAME 876
Query: 253 IVK----YSKDPLAKF 264
I+ + +PL KF
Sbjct: 877 ILNEFPGHGLEPLLKF 892
>gb|AAD47568.1|AF125578_1 (AF125578) DNA repair endonuclease [Drosophila melanogaster]
Length = 1236
Score = 70.2 bits (169), Expect = 3e-11
Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 62/299 (20%)
Query: 91 LEKRREAREEAEIKWKEALAKGDIEEARKYAQR-ATKVNEMLIEDAKKLLQLMGIPIVQA 149
L+ ++ + E E+ A + ++E R R +++ + D ++LL+L GIP + A
Sbjct: 818 LKSQKTSGELQEMATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGIPYIVA 877
Query: 150 PSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRNLTITGKRKMPGKDIYVEIKPEL 209
P E EAQ A++ + + + D D LFG + +N K M +
Sbjct: 878 PMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFR---------- 927
Query: 210 IVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI---------------- 253
E++ + R KLI+LA LVG+DY GI GIG ALEI
Sbjct: 928 --AEQIEQTFNCNRGKLIQLACLVGSDYTT-GIHGIGAVTALEILASFSGQDANGPGICN 984
Query: 254 -------VKY---------------SKDPLAKFQRQSDVDLY------AIKEFFLNPPTT 285
+K+ S LA ++ +++L+ A+ E +L PT
Sbjct: 985 QSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYL-APTI 1043
Query: 286 DDY--SLKWKEPDEEGIIRFLCDEHDFSEERVKNGLERLKKAIKAGK-QSTLESWFIKK 341
DD + W PD E I F ++ + + L + K I K Q ++ ++F K
Sbjct: 1044 DDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAK 1102
>pir||T22235 hypothetical protein F45G2.3 - Caenorhabditis elegans
>gi|3877245|emb|CAB07612.1| (Z93382) contains similarity
to Pfam domain: PF00752 (XPG N-terminal domain),
Score=63.6, E-value=1.4e-15, N=1; PF00867 (XPG
I-region), Score=98.9, E-value=3.3e-26, N=1; PF01576
(Myosin tail), Score=34.7, E-value=1e-08, N=2~cDNA EST
yk4a11.3 comes from>
Length = 1287
Score = 70.2 bits (169), Expect = 3e-11
Identities = 89/319 (27%), Positives = 141/319 (43%), Gaps = 44/319 (13%)
Query: 19 LYGKKIAIDALNAIYQFLSTIRQRDGTPLMDS--KGRIT-SHLSGLFYRTINLMEAGIKP 75
L GK +AID +S + R T MD G T S+++ + L+ G
Sbjct: 670 LRGKSVAID--------VSCLLHRGLTGCMDKIHMGEETQSYVNYVNKYVKELLGMGCHV 721
Query: 76 VYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKVNEMLIEDA 135
V VFDG+P KK E+RRE RE+ + + LAKG EAR + AT ++ ++E+
Sbjct: 722 VMVFDGRPLPAKKGTNEERRELREKRKEHAEMLLAKGLEREARDTYRLATSISADIVENT 781
Query: 136 KKLLQLM-GIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRL-VRNLTITGK 193
+ + M + IV AP E +AQ AY+ + V A ++D D ++FG + + + TG+
Sbjct: 782 IQYFRSMTNVDIVVAPYEADAQLAYLVQEKLVDAVITEDSDLIVFGCEMIYFKWQSATGE 841
Query: 194 RKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGPKKALEI 253
+Y + + E+ + K K + IL G DY G+ G+G A
Sbjct: 842 -----CSVYEKCNLKNCFTGELGGD-KFDFVKFRRICILSGCDYLQAGLPGVGLSTA--- 892
Query: 254 VKYSKDPLAKFQRQSDVD-----LYAIKEFFLNPPTTDDYSLKWKE-PDEEGIIRFLCDE 307
AKF + + L + + NP K KE ++E I F E
Sbjct: 893 --------AKFFSMTSIKDLRTLLRKVPSYLKNP--------KLKEHVNDEFIRNFEKAE 936
Query: 308 HDFSEERVKNGLERLKKAI 326
+ F + V + ER +K +
Sbjct: 937 NTFKHQIVFDPRERCQKPL 955
>emb|CAA61430.1| (X89021) Tosca [Drosophila melanogaster]
Length = 732
Score = 68.7 bits (165), Expect = 9e-11
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 24/254 (9%)
Query: 68 LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKV 127
L+ IKP+ VFDG+ K ++RR++R++++ + E L G IEEAR + +R V
Sbjct: 66 LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDV 125
Query: 128 NEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRN 187
+ + + + + AP E +AQ A++ ++D D LFG ++
Sbjct: 126 THDMTLRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFK 185
Query: 188 LTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGP 247
L + G + ++ E + L E K +K + IL G DY + GIG
Sbjct: 186 LDLNGSGLL--------VEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDY-LDSLPGIGL 236
Query: 248 KKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDE 307
KA + + L Q + L I + +++ E D++ I F+ E
Sbjct: 237 AKACKFI------LKTEQEDMRIALKKIPSYL---------NMRNLEVDDDYIENFMKAE 281
Query: 308 HDFSEERVKNGLER 321
F + N LER
Sbjct: 282 ATFRHMFIYNPLER 295
>emb|CAA61431.1| (X89022) Tosca [Drosophila melanogaster] >gi|7298467|gb|AAF53687.1|
(AE003660) tos gene product [Drosophila melanogaster]
Length = 732
Score = 68.7 bits (165), Expect = 9e-11
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 24/254 (9%)
Query: 68 LMEAGIKPVYVFDGKPPAFKKKELEKRREAREEAEIKWKEALAKGDIEEARKYAQRATKV 127
L+ IKP+ VFDG+ K ++RR++R++++ + E L G IEEAR + +R V
Sbjct: 66 LLSYDIKPILVFDGQHLPAKALTEKRRRDSRKQSKERAAELLRLGRIEEARSHMRRCVDV 125
Query: 128 NEMLIEDAKKLLQLMGIPIVQAPSEGEAQAAYMAGKGDVYASASQDYDSLLFGTPRLVRN 187
+ + + + + AP E +AQ A++ ++D D LFG ++
Sbjct: 126 THDMALRLIRECRSRNVDCIVAPYEADAQMAWLNRADVAQYIITEDSDLTLFGAKNIIFK 185
Query: 188 LTITGKRKMPGKDIYVEIKPELIVLEEVLKELKITREKLIELAILVGTDYNPGGIKGIGP 247
L + G + ++ E + L E K +K + IL G DY + GIG
Sbjct: 186 LDLNGSGLL--------VEAEKLHLAMGCTEEKYHFDKFRRMCILSGCDY-LDSLPGIGL 236
Query: 248 KKALEIVKYSKDPLAKFQRQSDVDLYAIKEFFLNPPTTDDYSLKWKEPDEEGIIRFLCDE 307
KA + + L Q + L I + +++ E D++ I F+ E
Sbjct: 237 AKACKFI------LKTEQEDMRIALKKIPSYL---------NMRNLEVDDDYIENFMKAE 281
Query: 308 HDFSEERVKNGLER 321
F + N LER
Sbjct: 282 ATFRHMFIYNPLER 295
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.316 0.137 0.385
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 130960674
Number of Sequences: 2977
Number of extensions: 5801016
Number of successful extensions: 16741
Number of sequences better than 1.0e-10: 53
Number of HSP's better than 0.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 16600
Number of HSP's gapped (non-prelim): 71
length of query: 343
length of database: 189,106,746
effective HSP length: 58
effective length of query: 285
effective length of database: 154,394,500
effective search space: 44002432500
effective search space used: 44002432500
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 165 (68.7 bits)