BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1936 (pyrD) DE:dihydroorotase dehydrogenase (pyrD)
(303 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9V0Y6|PYRD_PYRAB DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 601 e-171
sp|O59185|PYRD_PYRHO DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 536 e-152
sp|Q58070|PYRD_METJA DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 317 7e-86
sp|O27281|PYRD_METTH DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 305 4e-82
emb|CAC11547.1| (AL445064) DIHYDROOROTATE DEHYDROGENASE B relate... 277 9e-74
sp|P25996|PYRD_BACSU DIHYDROOROTATE DEHYDROGENASE, CATALYTIC SUB... 242 4e-63
gi|11498351 dihydroorotase dehydrogenase (pyrD) [Archaeoglobus f... 235 5e-61
sp|Q9YFI6|PYRD_AERPE DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 228 5e-59
sp|O66461|PYRD_AQUAE DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 226 3e-58
sp|P46539|PYRD_BACCL DIHYDROOROTATE DEHYDROGENASE, CATALYTIC SUB... 220 1e-56
sp|Q47741|PYDB_ENTFA DIHYDROOROTATE DEHYDROGENASE B, CATALYTIC S... 210 1e-53
dbj|BAB06253.1| (AP001515) dihydroorotate dehydrogenase [Bacillu... 206 3e-52
sp|P54322|PYDB_LACLC DIHYDROOROTATE DEHYDROGENASE B, CATALYTIC S... 199 3e-50
pir||B64983 yeiA protein - Escherichia coli (strain K-12) >gi|17... 198 6e-50
sp|P25889|YEIA_ECOLI HYPOTHETICAL 45.1 KD PROTEIN IN CDD-MGLC IN... 198 6e-50
sp|P77887|PYRD_LACPL DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 177 1e-43
sp|O08358|PYRD_SULAC DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 176 3e-43
gb|AAK40921.1| Dihydroorotate dehydrogenase (dihydroorotate oxid... 173 2e-42
sp|Q9UX04|PYRD_SULSO DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 173 2e-42
pir||F83590 probable oxidoreductase PA0439 [imported] - Pseudomo... 163 2e-39
emb|CAA73354.1| (Y12823) dihydroorotate oxidase [Sulfolobus acid... 158 9e-38
sp|Q18164|DPYD_CAEEL PROBABLE DIHYDROPYRIMIDINE DEHYDROGENASE [N... 151 9e-36
gb|AAF46461.2| (AE003446) Reg-3 gene product [Drosophila melanog... 150 1e-35
sp|P54321|PYDA_LACLC DIHYDROOROTATE DEHYDROGENASE A (DIHYDROOROT... 145 6e-34
sp|Q28943|DPYD_PIG DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] PRECU... 140 2e-32
gi|4503373 dihydropyrimidine dehydrogenase [Homo sapiens] >gi|24... 139 5e-32
gb|AAB51366.1| (U20938) No definition line found [Homo sapiens] ... 139 5e-32
dbj|BAB02704.1| (AB019230) senescencs-related protein; dihydroor... 139 5e-32
gb|AAC47288.1| (U65491) Dreg-3 protein [Drosophila melanogaster] 136 4e-31
sp|Q9X9S0|PYRD_STRPN DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 136 4e-31
dbj|BAA33218.1| (D85035) dihydropyrimidine dehydrogenase [Rattus... 135 6e-31
dbj|BAA86060.1| (AB014457) senescencs-related protein [Pyrus pyr... 134 1e-30
sp|Q28007|DPYD_BOVIN DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] (DP... 132 6e-30
sp|Q9WYG8|PYRD_THEMA DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 131 8e-30
gi|6322633 dihydroorotate dehydrogenase; Ura1p [Saccharomyces ce... 129 4e-29
pir||T30523 dihydroorotate dehydrogenase (EC 1.3.99.11) - Trypan... 120 2e-26
gb|AAG20569.1| (AE005127) dihydroorotate dehydrogenase; PyrD [Ha... 120 2e-26
dbj|BAA94299.1| (AB029444) Dihydroorotate dehydrogenase [Leishma... 110 2e-23
pir||I51850 dihydroorotate oxidase (EC 1.3.3.1) - black rat 104 1e-21
sp|Q63707|PYRD_RAT DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIHYD... 104 1e-21
gi|9910194 dihydroorotate dehydrogenase [Mus musculus] >gi|87840... 102 5e-21
sp|Q02127|PYRD_HUMAN DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIH... 99 4e-20
pdb|1D3G|A Chain A, Human Dihydroorotate Dehydrogenase Complexed... 99 4e-20
sp|O06236|PYRD_MYCTU DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 99 8e-20
pir||JN0500 dihydroorotate oxidase (EC 1.3.3.1), mitochondrial -... 98 1e-19
pir||PC1219 dihydroorotate oxidase (EC 1.3.3.1) precursor - human 96 4e-19
pir||S72881 dihydroorotate oxidase (EC 1.3.3.1) - Mycobacterium ... 91 1e-17
sp|O25655|PYRD_HELPY DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 91 1e-17
pir||D81352 dihydroorotate oxidase (EC 1.3.3.1) Cj0804 [imported... 91 1e-17
sp|P32748|PYRD_DROME DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIH... 90 3e-17
sp|P46727|PYRD_MYCLE DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 90 4e-17
pir||D82193 dihydroorotate dehydrogenase VC1491 [imported] - Vib... 90 4e-17
sp|Q9RX14|PYRD_DEIRA DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 89 5e-17
pir||T15209 hypothetical protein W02D3.2 - Caenorhabditis elegan... 88 1e-16
gb|AAG03363.1| (AF024666) PyrD [Corynebacterium striatum] 87 3e-16
sp|Q9ZM11|PYRD_HELPJ DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 85 1e-15
sp|P05021|PYRD_ECOLI DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 85 1e-15
pir||G81222 dihydroorotate dehydrogenase NMB0221 [imported] - Ne... 84 2e-15
pir||D81995 dihydroorotate oxidase (EC 1.3.3.1) NMA0042 [importe... 84 2e-15
emb|CAB93362.1| (AL357523) dihydroorotate dehydrogenase [Strepto... 83 5e-15
pir||A83263 dihydroorotate dehydrogenase PA3050 [imported] - Pse... 82 1e-14
sp|P32747|PYRD_SCHPO DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIH... 82 1e-14
sp|P74782|PYRD_SYNY3 DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 80 4e-14
sp|P25468|PYRD_SALTY DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTAT... 78 1e-13
dbj|BAA18627.1| (D90916) dihydroorotate dehydrogenase [Synechocy... 76 6e-13
pir||S77079 hypothetical protein sll0744 - Synechocystis sp. (st... 74 2e-12
dbj|BAB11988.1| (AB038557) dihydroorotate dehydrogenase [Oryza s... 73 3e-12
pir||F82541 dihydroorotate dehydrogenase XF2571 [imported] - Xyl... 72 7e-12
pir||S13824 dihydroorotate oxidase (EC 1.3.3.1) - Salmonella typ... 72 9e-12
gb|AAF36476.1|AF128264_1 (AF128264) dihydroorotate dehydrogenase... 69 8e-11
>sp|Q9V0Y6|PYRD_PYRAB DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431638|pir||E75106 dihydroorotase
dehydrogenase (pyrd) PAB1936 - Pyrococcus abyssi (strain
Orsay) >gi|5458077|emb|CAB49566.1| (AJ248285)
dihydroorotase dehydrogenase (pyrD) [Pyrococcus abyssi]
Length = 303
Score = 601 bits (1534), Expect = e-171
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MVRGMLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENP 60
MVRGMLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENP
Sbjct: 1 MVRGMLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENP 60
Query: 61 TIVELPYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD 120
TIVELPYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD
Sbjct: 61 TIVELPYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD 120
Query: 121 AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEK 180
AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEK
Sbjct: 121 AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEK 180
Query: 181 AGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGI 240
AGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGI
Sbjct: 181 AGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGI 240
Query: 241 GGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLA 300
GGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLA
Sbjct: 241 GGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLA 300
Query: 301 LKV 303
LKV
Sbjct: 301 LKV 303
>sp|O59185|PYRD_PYRHO DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431633|pir||H71027 probable
dihydroorotate dehydrogenase - Pyrococcus horikoshii
>gi|3257941|dbj|BAA30624.1| (AP000006) 303aa long
hypothetical dihydroorotate dehydrogenase [Pyrococcus
horikoshii]
Length = 303
Score = 536 bits (1367), Expect = e-152
Identities = 266/303 (87%), Positives = 284/303 (92%)
Query: 1 MVRGMLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENP 60
MV+ MLEV LFGI+F+NPLILASGVVDMTPELLRRAH EGAGGVVTKSIG EPRKGY+NP
Sbjct: 1 MVKRMLEVKLFGIRFENPLILASGVVDMTPELLRRAHNEGAGGVVTKSIGKEPRKGYDNP 60
Query: 61 TIVELPYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD 120
TIVELPYGLINAMGLPNPGWEAFL EF E+FDFPVIVSIFGGTPEEFAFLAEKL VAD
Sbjct: 61 TIVELPYGLINAMGLPNPGWEAFLNEFIDERFDFPVIVSIFGGTPEEFAFLAEKLEPVAD 120
Query: 121 AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEK 180
AFELNLSCPHAKGYGMEIGQ P+NVYEVVKAVKDVTDKPVIAKLTPNV+DI +LGLAAE+
Sbjct: 121 AFELNLSCPHAKGYGMEIGQDPKNVYEVVKAVKDVTDKPVIAKLTPNVNDITKLGLAAER 180
Query: 181 AGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGI 240
GADGVSAINTVKAIAIDIYAKRPILSNK GGYSGPG+KPIALRAVYDLA LDIPVIGI
Sbjct: 181 GGADGVSAINTVKAIAIDIYAKRPILSNKVGGYSGPGIKPIALRAVYDLAKVLDIPVIGI 240
Query: 241 GGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLA 300
GGIT+W+DAVEFLLAGASALQIGTAVYLRGF VF+EI+ GI YLKEEG+SS+++IIGLA
Sbjct: 241 GGITSWRDAVEFLLAGASALQIGTAVYLRGFKVFKEISNGIIEYLKEEGFSSIRDIIGLA 300
Query: 301 LKV 303
LKV
Sbjct: 301 LKV 303
>sp|Q58070|PYRD_METJA DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|2127850|pir||F64381 dihydroorotate
oxidase (EC 1.3.3.1) - Methanococcus jannaschii
>gi|1591367|gb|AAB98649.1| (U67513) dihydroorotase
dehydrogenase (pyrD) [Methanococcus jannaschii]
Length = 306
Score = 317 bits (805), Expect = 7e-86
Identities = 156/301 (51%), Positives = 215/301 (70%), Gaps = 6/301 (1%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
ML+ N+ GI+FKNP+ LASG++ T L+R + GAG V TKSIG+ P G++NPTIVE
Sbjct: 5 MLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGLNPNPGHKNPTIVE 64
Query: 65 LPYGLINAMGLPNPGWEAFLEEFRK-----EKFDFPVIVSIFGGTPEEFAFLAEKLGEVA 119
+ G +NAMGLPNPG + +LEE K + D +I SI+G EEFA +A+K+
Sbjct: 65 VYGGFLNAMGLPNPGVDEYLEEIEKVRDELNRMDVRIIGSIYGKDEEEFAEVAKKMERYV 124
Query: 120 DAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAE 179
D ELN+SCPHAKGYG IGQ P+ Y+V KAVK PV AKLTPNV+DI E+ A
Sbjct: 125 DIIELNISCPHAKGYGATIGQNPDLSYDVCKAVKKAVKIPVFAKLTPNVTDIIEIAQAVV 184
Query: 180 KAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIG 239
AG DG+ AINTV+ +AIDI AK+PIL+NKFGG SG +K I ++ V+DL + D+P+IG
Sbjct: 185 DAGVDGLVAINTVRGMAIDIRAKKPILANKFGGLSGKAIKSIGIKVVWDLYENFDVPIIG 244
Query: 240 IGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGL 299
+GGI + +DA+E+++AGASA+QIG+ VY RG+ +F+++ + I +LKEE +++EI+G+
Sbjct: 245 VGGIMSGEDAIEYMMAGASAVQIGSGVYYRGYDIFKKVCDEIISFLKEENL-TLEEIVGM 303
Query: 300 A 300
A
Sbjct: 304 A 304
>sp|O27281|PYRD_METTH DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431634|pir||A69029 dihydroorotate
oxidase - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2622323|gb|AAB85702.1| (AE000889)
dihydroorotate oxidase [Methanobacterium
thermoautotrophicum]
Length = 303
Score = 305 bits (773), Expect = 4e-82
Identities = 154/298 (51%), Positives = 205/298 (68%), Gaps = 2/298 (0%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLE ++ I+ +NP ILA+GV+ L R +R GAG VVTKS + P GY NPT VE
Sbjct: 4 MLETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSLRPNPGYRNPTTVE 63
Query: 65 LPYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVADAFEL 124
+ G+INA+GL NPG EAF EE + + P+I S++G +PEEFA A + E AD EL
Sbjct: 64 VTGGVINAIGLSNPGVEAFREELKLVDEEVPLIASVYGASPEEFASAAASVEEYADMIEL 123
Query: 125 NLSCPHA-KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGA 183
N+SCPHA G G IGQ PE + VV AVKD D P+ KLTPNV+DI E+ +AE+AG+
Sbjct: 124 NVSCPHAMAGCGASIGQDPELTFRVVSAVKDAVDVPISTKLTPNVTDIVEIAGSAEEAGS 183
Query: 184 DGVSAINTV-KAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIGG 242
D ++ IN++ + IDI RPILSN FGG SGP +KP+A+R VYD+ S+DIP++G+GG
Sbjct: 184 DALTLINSLGPGMKIDIKTARPILSNAFGGMSGPAIKPVAVRCVYDVYRSVDIPIMGVGG 243
Query: 243 ITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLA 300
+ +QDAVEFL AGA A+Q+GTA+ G VF +I G+ ++ EG+SSV E++GLA
Sbjct: 244 VRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKICRGLEAFMMAEGFSSVDEMVGLA 301
>emb|CAC11547.1| (AL445064) DIHYDROOROTATE DEHYDROGENASE B related protein
[Thermoplasma acidophilum]
Length = 300
Score = 277 bits (702), Expect = 9e-74
Identities = 144/299 (48%), Positives = 200/299 (66%), Gaps = 4/299 (1%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L ++ GI+ +NPL+LASG++D + GA VVTKSIGME R GY P IVE
Sbjct: 4 LSTSVAGIRLENPLMLASGILDENGYTMLDVMNNGAAAVVTKSIGMEERNGYSAPVIVEY 63
Query: 66 PYGLINAMGLPNPGWEAFLEEFR-KEKFDFPVIVSIFGGTPEEFAFLAEKLGEVA-DAFE 123
LINA+GL NPG + F EE R ++ PVI S+F E F L K+ E DA E
Sbjct: 64 GDSLINAVGLSNPGIDNFAEEIRIAKRSGKPVIGSVFASDAESFVNLGRKMQEYGCDAVE 123
Query: 124 LNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGA 183
LNLSCPH KG+G+E+G P+ V ++V +K PV AKL+PNVSDI E+ AAEKA
Sbjct: 124 LNLSCPHVKGFGLEVGSDPDLVEDIVNEMKSKISVPVFAKLSPNVSDIIEIAKAAEKA-- 181
Query: 184 DGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIGGI 243
D INTVKA+ IDI A+ P+L+N +GG SGP +KP+ +R VY++ +IG+GGI
Sbjct: 182 DAYVLINTVKAMKIDIRARMPVLTNAYGGLSGPAIKPVGVRYVYEVKKETGKDIIGVGGI 241
Query: 244 TTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLALK 302
TT++DAVE+++AGASA+QIGTA+Y G SVFR I ++ ++ +E + S+++++G+A++
Sbjct: 242 TTYEDAVEYIMAGASAVQIGTALYTVGKSVFRNIISQMNTFMDDEKFHSIQDMVGVAIR 300
>sp|P25996|PYRD_BACSU DIHYDROOROTATE DEHYDROGENASE, CATALYTIC SUBUNIT (DIHYDROOROTATE
OXIDASE) (DHODEHASE) (DHODASE) (DHOD)
>gi|98279|pir||H39845 dihydroorotate oxidase (EC
1.3.3.1) pyrD - Bacillus subtilis
>gi|143392|gb|AAA21272.1| (M59757) dihydroorotase
dehydrogenase [Bacillus subtilis]
>gi|2633927|emb|CAB13428.1| (Z99112) dihydroorotate
dehydrogenase [Bacillus subtilis]
Length = 311
Score = 242 bits (611), Expect = 4e-63
Identities = 128/298 (42%), Positives = 191/298 (63%), Gaps = 5/298 (1%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLEV L G+ KNP+I ASG E R G ++ K+ EPR G P + E
Sbjct: 1 MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKATTKEPRFGNPTPRVAE 60
Query: 65 LPYGLINAMGLPNPGWEAFLEEFRK--EKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD-- 120
G++NA+GL NPG ++ L E+FD P+I ++ G +++ +AE + + +
Sbjct: 61 TGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQVDDYVEVAEHISKAPNVH 120
Query: 121 AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEK 180
A ELN+SCP+ K G+ G PE ++ KAVK+V+D PV KL+PNV++I E+ LA E+
Sbjct: 121 ALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPVYVKLSPNVANITEIALAIEE 180
Query: 181 AGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGI 240
AGADG++ INT+ + +D+ +PIL+NK GG SGP VKP+A+R VY+++ ++IP+IG+
Sbjct: 181 AGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVYEVSQMVNIPIIGM 240
Query: 241 GGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIG 298
GG+ T +DA+EFLLAGASA+ +GTA ++ F+ EI E + L + GY S++E IG
Sbjct: 241 GGVQTAEDALEFLLAGASAVAVGTANFVNPFAC-PEIIEQLPSVLLQYGYQSIEECIG 297
>gi|11498351 dihydroorotase dehydrogenase (pyrD) [Archaeoglobus fulgidus]
>gi|3914509|sp|O29513|PYRD_ARCFU DIHYDROOROTATE
DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431635|pir||A69343 dihydroorotase
dehydrogenase (pyrD) homolog - Archaeoglobus fulgidus
>gi|2649866|gb|AAB90494.1| (AE001053) dihydroorotase
dehydrogenase (pyrD) [Archaeoglobus fulgidus]
Length = 299
Score = 235 bits (593), Expect = 5e-61
Identities = 123/298 (41%), Positives = 189/298 (63%), Gaps = 7/298 (2%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
LE + G++ KNPL+LASG++ L R+ AG VVTKS+G+E R+GY NPT+V
Sbjct: 4 LETEIGGLRMKNPLMLASGIMGSKVHSLNLIARD-AGAVVTKSVGVEEREGYRNPTVVNW 62
Query: 66 PYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD---AF 122
GLINA+GL +P + F EE + + P+++S++G + EEF+ L + +
Sbjct: 63 KCGLINAVGLASPAAKDFAEELKDYTNEAPLLISLYGHSVEEFSDLVDTFDSALPYLHGY 122
Query: 123 ELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAG 182
ELNLSCPH KG G++IG E +V+ +K T PV AKL+ + D +L E AG
Sbjct: 123 ELNLSCPHVKGAGLDIGMDLELSAAIVEELKGKTKNPVFAKLSA-MHDYLKLAKVLEDAG 181
Query: 183 ADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIGG 242
DG++ NT++ + IDI + +P+LSN GG SGP +KPIAL+ VYDL +++P++G GG
Sbjct: 182 VDGITISNTLRGMKIDIMSGKPVLSNLSGGVSGPAIKPIALKCVYDLYKEIEVPIVGCGG 241
Query: 243 ITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLA 300
IT+++D +EF++AGA A+QIG+AVY +F + E + + + ++ ++IG+A
Sbjct: 242 ITSFEDVLEFIMAGARAVQIGSAVYY-SRRIFYSLKESLIAFTRARD-CTISDLIGIA 297
>sp|Q9YFI6|PYRD_AERPE DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431639|pir||E72784 probable
dihydroorotate dehydrogenase APE0260 - Aeropyrum pernix
(strain K1) >gi|5103654|dbj|BAA79175.1| (AP000058) 309aa
long hypothetical dihydroorotate dehydrogenase
[Aeropyrum pernix]
Length = 309
Score = 228 bits (576), Expect = 5e-59
Identities = 126/299 (42%), Positives = 179/299 (59%), Gaps = 6/299 (2%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L +++ G++ + P+ ASG++ P R G G V KS+ +PRKGY P + +
Sbjct: 10 LSISIAGLRLQRPVGNASGILGWEPREARLVEEGGGGFFVAKSVTYQPRKGYPQPHLYPV 69
Query: 66 PYGLINAMGLPNPGWEAFLEEFRK--EKFDFPVIVSIFGGTPEEFAFLAEKLGEVA-DAF 122
G++NA+GL NPG+ + + E+ PVI SI GG P E+ +A L E A
Sbjct: 70 AGGIVNAVGLANPGFREASKMLAQTVEEASIPVIASIAGGAPGEWVEMASTLEEAGVSAV 129
Query: 123 ELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSD-IRELGLAAEKA 181
ELNLSCPH G G+E+GQ P V VV AV PVIAKL SD + + A +A
Sbjct: 130 ELNLSCPHFAGGGLELGQDPAAVASVVSAVASTLRIPVIAKL--GYSDRLVDAASKALEA 187
Query: 182 GADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIG 241
GA G++ IN+++A+ ID+YAK+P+L N+ GG SG + PIA+RAVY++ + G
Sbjct: 188 GARGLTLINSMRAMKIDVYAKKPVLGNRVGGLSGKPIHPIAVRAVYEVYGETRADIFAAG 247
Query: 242 GITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLA 300
G+ +W+DAVEF LAGA A+Q+G A G V R I EG+ RYL EG+ S+++I+G A
Sbjct: 248 GVESWEDAVEFYLAGAKAVQVGAAFITIGPHVLRSIVEGVRRYLWVEGFRSLQDIVGYA 306
>sp|O66461|PYRD_AQUAE DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431636|pir||B70304 dihydroorotase
dehydrogenase - Aquifex aeolicus
>gi|2982802|gb|AAC06426.1| (AE000671) dihydroorotase
dehydrogenase [Aquifex aeolicus]
Length = 306
Score = 226 bits (570), Expect = 3e-58
Identities = 125/305 (40%), Positives = 185/305 (59%), Gaps = 9/305 (2%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L V LFGI+FKNP+ +ASG E G VVTK + ++ R G E P IVE
Sbjct: 3 LSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKERLGNETPRIVET 62
Query: 66 PYGLINAMGLPNPGWEAFLEEF--RKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD--- 120
P G++N++GL NPG E FL+E + + D I ++FG T EE+ + L E AD
Sbjct: 63 PCGMLNSIGLQNPGVEKFLKEIYPKIKDVDTHFIANVFGETEEEYVEVCMAL-EDADKIV 121
Query: 121 AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEK 180
A+ELN+SCP+ K G+ G P + +V +K KP++ KL+PNV+D+ E +
Sbjct: 122 AYELNVSCPNVKKGGILFGHDPVILGNLVDRIKAKIKKPLLVKLSPNVTDVTEFAKVCIE 181
Query: 181 AGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLD--IPVI 238
GADG+ INT+ + I+I+ ++P L+ K GG SGP + PIA+R +Y + IP+I
Sbjct: 182 NGADGLVLINTLMGMKINIWKRKPDLATKTGGLSGPAILPIAVRMIYQVYEKFGDRIPII 241
Query: 239 GIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIG 298
G+GGITTW+DA+E ++AGASA+Q+GTA + + + + EGI ++K + KE+IG
Sbjct: 242 GVGGITTWEDAMEHVMAGASAVQVGTANFYEPLAPLK-VIEGIENFMKSQNIKDFKELIG 300
Query: 299 LALKV 303
+A +V
Sbjct: 301 IAHRV 305
>sp|P46539|PYRD_BACCL DIHYDROOROTATE DEHYDROGENASE, CATALYTIC SUBUNIT (DIHYDROOROTATE
OXIDASE) (DHODEHASE) (DHODASE) (DHOD)
>gi|2117535|pir||I40171 dihydroorotate oxidase (EC
1.3.3.1) - Bacillus caldolyticus
>gi|312445|emb|CAA51741.1| (X73308) dihydroorotate
oxidase [Bacillus caldolyticus]
Length = 313
Score = 220 bits (556), Expect = 1e-56
Identities = 123/301 (40%), Positives = 179/301 (58%), Gaps = 5/301 (1%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L V L G+ KNP++ ASG E R G ++ K+ EPR G P + E
Sbjct: 4 LAVELPGLSLKNPIMPASGCFGFGREYARFYDLSVLGAIMIKATTKEPRFGNPTPRVAET 63
Query: 66 PYGLINAMGLPNPGWEAFLEEFRK--EKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD--A 121
P G++NA+GL NPG + LEE E+FD P+I +I G T EE+ +AE + + + A
Sbjct: 64 PGGMLNAIGLQNPGLDKVLEEELPWLEQFDVPIIANIAGSTVEEYVEVAEAISKAPNVHA 123
Query: 122 FELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKA 181
ELN+SCP+ K G+ G P+ E+ + VK+V PV ++PNV+DI + A E+A
Sbjct: 124 LELNISCPNVKKGGIAFGTVPDVAAELTRLVKEVAAVPVYVNVSPNVTDIVAMAKAIEQA 183
Query: 182 GADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIG 241
GADG++ INT+ + ID+ RPIL+N GG SGP VKPIA+R +Y+++ ++ IP+IG+G
Sbjct: 184 GADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKPIAIRMIYEVSQAVSIPIIGMG 243
Query: 242 GITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLAL 301
GI T +D +EF AGASA+ +GTA ++ F V I + L + G + E IG +
Sbjct: 244 GIQTAEDVLEFFYAGASAVAVGTANFVDPF-VCPTIIADLPALLDDLGIGHISECIGRSW 302
Query: 302 K 302
K
Sbjct: 303 K 303
>sp|Q47741|PYDB_ENTFA DIHYDROOROTATE DEHYDROGENASE B, CATALYTIC SUBUNIT (DIHYDROOROTATE
OXIDASE B) (DHODEHASE B) (DHODASE B) (DHOD B)
>gi|818705|gb|AAA67066.1| (U24692) pyrimidine
biosynthesis D [Enterococcus faecalis]
>gi|1585613|prf||2201400A pyrD gene [Enterococcus
faecalis]
Length = 312
Score = 210 bits (530), Expect = 1e-53
Identities = 108/302 (35%), Positives = 183/302 (59%), Gaps = 6/302 (1%)
Query: 1 MVRGMLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENP 60
M++ L V++ G+ KNP+I ASG E + G ++ K+ + R G P
Sbjct: 1 MMKNPLAVSIPGLTLKNPIIPASGCFGFGEEYANYYDLDQLGSIMIKATTPQARYGNPTP 60
Query: 61 TIVELPYGLINAMGLPNPGWEAFLEEF--RKEKF-DFPVIVSIFGGTPEEFAFLAEKLGE 117
+ E P G++NA+GL NPG + ++E + EK+ + P+I ++ G E++ + K+G+
Sbjct: 61 RVAETPSGMLNAIGLQNPGLDVVMQEKLPKLEKYPNLPIIANVAGACEEDYVAVCAKIGQ 120
Query: 118 VAD--AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELG 175
+ A ELN+SCP+ K G+ G PE +++ +AVK V P+ KL+PNV+DI +
Sbjct: 121 APNVKAIELNISCPNVKHGGIAFGTDPEVAFQLTQAVKKVASVPIYVKLSPNVTDIVPIA 180
Query: 176 LAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDI 235
A E GADG S INT+ + ID+ ++PIL+N+ GG SGP +KP+A+R + +AS +
Sbjct: 181 QAIEAGGADGFSMINTLLGMRIDLKTRKPILANQTGGLSGPAIKPVAIRLIRQVASVSQL 240
Query: 236 PVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKE 295
P+IG+GG+ T D +E +AGASA+ +GTA + + + ++ +G+ + ++E G S+++
Sbjct: 241 PIIGMGGVQTVDDVLEMFMAGASAVGVGTANFTDPY-ICPKLIDGLPKRMEELGIESLEQ 299
Query: 296 II 297
+I
Sbjct: 300 LI 301
>dbj|BAB06253.1| (AP001515) dihydroorotate dehydrogenase [Bacillus halodurans]
Length = 305
Score = 206 bits (518), Expect = 3e-52
Identities = 111/297 (37%), Positives = 173/297 (57%), Gaps = 5/297 (1%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L V L G+ KNP++ ASG E G + K+ +EPR G P + E
Sbjct: 4 LAVELPGLSMKNPIMPASGCFGFGKEFAGFYDLNHLGAIAIKATTVEPRFGNPTPRVAET 63
Query: 66 PYGLINAMGLPNPGWEAFLEE--FRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVAD--A 121
G++NA+GL NPG ++ R D P++ +I G T ++ +AE + V + A
Sbjct: 64 HSGMLNAIGLQNPGLNNVIDNELARLADVDVPIVANIAGSTVNDYVEVAEAISRVDNVHA 123
Query: 122 FELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKA 181
ELN+SCP+ K G+ G P+ ++ + VK V+ PV KL+PNVSDI E+ A E+A
Sbjct: 124 LELNISCPNVKEGGIAFGTVPDVAAQLTQEVKRVSTVPVYVKLSPNVSDIVEMAQAVERA 183
Query: 182 GADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIG 241
GADG+S INT+ + +D+ + PIL+N GG SGP +KP+A+R +Y ++ ++ IP+IG+G
Sbjct: 184 GADGLSMINTLLGMRLDLKRRTPILANGTGGLSGPAIKPVAIRMIYQVSQAVSIPIIGMG 243
Query: 242 GITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIG 298
GI + D +EF+LAGA A+ +GTA + + V I + + + + E G + +I+G
Sbjct: 244 GIQSADDVLEFMLAGADAVAVGTANFTDPY-VCPTIIDELPKRMDELGIERIADIVG 299
>sp|P54322|PYDB_LACLC DIHYDROOROTATE DEHYDROGENASE B, CATALYTIC SUBUNIT (DIHYDROOROTATE
OXIDASE B) (DHODEHASE B) (DHODASE B) (DHOD B)
>gi|511017|emb|CAA52280.1| (X74207) dihydroorotate
dehydrogenase B [Lactococcus lactis]
Length = 311
Score = 199 bits (501), Expect = 3e-50
Identities = 109/300 (36%), Positives = 171/300 (56%), Gaps = 9/300 (3%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L V L G+ KNP+I ASG E + G ++ K+ + PR G P + E
Sbjct: 7 LSVKLPGLDLKNPIIPASGCFGFGEEYAKYYDLNKLGSIMVKATTLHPRFGNPTPRVAET 66
Query: 66 PYGLINAMGLPNPGWEAFLEE---FRKEKF-DFPVIVSIFGGTPEEFAFLAEKLGEVAD- 120
G++NA+GL NPG E + E + E F + P+I ++ G ++ + K+G+ A+
Sbjct: 67 ASGMLNAIGLQNPGLEVIMTEKLPWLNENFPELPIIANVAGSEEADYVAVCAKIGDRANV 126
Query: 121 -AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAE 179
A ELN+SCP+ K G G PE +VKA K V+ P+ KL+PNV+DI + A E
Sbjct: 127 KAIELNISCPNVKHGGQAFGTDPEVAAALVKACKAVSKVPLYVKLSPNVTDIVPIAKAVE 186
Query: 180 KAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIG 239
AGADG++ INT+ + D+ ++PIL+N GG SGP +KP+AL+ ++ +A +DIP+IG
Sbjct: 187 AAGADGLTMINTLMGVRFDLKTRQPILANITGGLSGPAIKPVALKLIHQVAQDVDIPIIG 246
Query: 240 IGGITTWQDAVEFLLAGASALQIGTAVYLRGF---SVFREIAEGISRYLKEEGYSSVKEI 296
+GG+ Q +E +AGAS + +GTA + F + ++ E + +Y E S ++E+
Sbjct: 247 MGGVANAQVVLEMYMAGASRVAVGTANFADPFVCPKIIDKLPELMDQYRIESLESLIQEV 306
>pir||B64983 yeiA protein - Escherichia coli (strain K-12)
>gi|1788469|gb|AAC75208.1| (AE000303) putative
oxidoreductase [Escherichia coli K12]
Length = 413
Score = 198 bits (499), Expect = 6e-50
Identities = 125/318 (39%), Positives = 184/318 (57%), Gaps = 27/318 (8%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIG------MEPRKGYEN 59
L + G+KF NP L+S V E+ +A+ G GGVV K+IG + PR +
Sbjct: 8 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH-- 65
Query: 60 PTIVELPYGLI---NAMGLPNPGWEAFLEEFRKEKFDFP---VIVSIFGGTPEEFAFLAE 113
+V+ G I N + E L R+ K D+P +I SI G +++ LA
Sbjct: 66 --LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 123
Query: 114 KLGEV-ADAFELNLSCPHAKGYGM--EIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSD 170
+ E AD E N SCP + M ++GQ PE V + +AVK + P++AK+TPN+ D
Sbjct: 124 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 183
Query: 171 IRELGLAAEKAGADGVSAINTVKAIA-IDIYAK--RPILSNK--FGGYSGPGVKPIALRA 225
+ E+ LAA++ GADG++AINTVK+I ID+ K PI++ K GYSG VKPIALR
Sbjct: 184 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 243
Query: 226 VYDLASS---LDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGIS 282
+ + + D P+ GIGGI TW+DA EFLL GA+ LQ+ T + G+ + ++A G+S
Sbjct: 244 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 303
Query: 283 RYLKEEGYSSVKEIIGLA 300
YL ++G+ S++E++GLA
Sbjct: 304 HYLADQGFDSLQEMVGLA 321
>sp|P25889|YEIA_ECOLI HYPOTHETICAL 45.1 KD PROTEIN IN CDD-MGLC INTERGENIC REGION
Length = 411
Score = 198 bits (499), Expect = 6e-50
Identities = 125/318 (39%), Positives = 184/318 (57%), Gaps = 27/318 (8%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIG------MEPRKGYEN 59
L + G+KF NP L+S V E+ +A+ G GGVV K+IG + PR +
Sbjct: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH-- 63
Query: 60 PTIVELPYGLI---NAMGLPNPGWEAFLEEFRKEKFDFP---VIVSIFGGTPEEFAFLAE 113
+V+ G I N + E L R+ K D+P +I SI G +++ LA
Sbjct: 64 --LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121
Query: 114 KLGEV-ADAFELNLSCPHAKGYGM--EIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSD 170
+ E AD E N SCP + M ++GQ PE V + +AVK + P++AK+TPN+ D
Sbjct: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181
Query: 171 IRELGLAAEKAGADGVSAINTVKAIA-IDIYAK--RPILSNK--FGGYSGPGVKPIALRA 225
+ E+ LAA++ GADG++AINTVK+I ID+ K PI++ K GYSG VKPIALR
Sbjct: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241
Query: 226 VYDLASS---LDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGIS 282
+ + + D P+ GIGGI TW+DA EFLL GA+ LQ+ T + G+ + ++A G+S
Sbjct: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301
Query: 283 RYLKEEGYSSVKEIIGLA 300
YL ++G+ S++E++GLA
Sbjct: 302 HYLADQGFDSLQEMVGLA 319
>sp|P77887|PYRD_LACPL DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|1514604|emb|CAA91006.1| (Z54240)
dihydroorotate dehydrogenase [Lactobacillus plantarum]
Length = 298
Score = 177 bits (445), Expect = 1e-43
Identities = 93/248 (37%), Positives = 141/248 (56%), Gaps = 6/248 (2%)
Query: 4 GMLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIV 63
G L VNL G+ FKNP++ ASG ++ ++ GG+V KS EP+ G PT
Sbjct: 2 GRLTVNLAGVTFKNPVMPASGTAAYGQQMAQQLDLSALGGLVIKSTTAEPKAGNPRPTTA 61
Query: 64 ELPYGLINAMGLPNPGWEAFLEE----FRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVA 119
E G +NA+GL NPG + L + D P+I S+ G + +E+ +A K+
Sbjct: 62 ETTAGWLNAIGLKNPGIDNVLADKLPWLATHYPDLPIIGSVAGASFDEYVAVARKMASAP 121
Query: 120 DA--FELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLA 177
+ E+N+SCP+ G+ G P V + KA+ DKPV KLTPNV+DI + LA
Sbjct: 122 NVKLLEINISCPNVDHGGLAFGTDPATVTALTKAIVAAVDKPVFMKLTPNVTDIVPIALA 181
Query: 178 AEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPV 237
AE GA G++ INT+ + ID+ ++PIL++ GG SG + P+A+R ++D+ +P+
Sbjct: 182 AEAGGAAGLTMINTLTGMGIDLATRQPILAHGTGGLSGKAIHPLAVRMIHDVRQHTKLPI 241
Query: 238 IGIGGITT 245
IG+GG+ T
Sbjct: 242 IGVGGVFT 249
>sp|O08358|PYRD_SULAC DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD)
Length = 291
Score = 176 bits (442), Expect = 3e-43
Identities = 103/297 (34%), Positives = 171/297 (56%), Gaps = 10/297 (3%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRRA-HREGAGGVVTKSIGMEPRKGYENPTIVELP 66
+ + G+ F++P+++ASG+V T E ++ + + +K++ P + + +PT V++
Sbjct: 2 IQVAGVNFEDPIVIASGIVPPTKEYMQNVCEKYEPSAITSKTLTYSPLEPHRSPTFVKIS 61
Query: 67 YGL-INAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVADAFELN 125
+NA+GL NPG + L + + K +I+SI G E+ K+ ++ ELN
Sbjct: 62 DNCYLNAIGLGNPGIQ-ILRDLGEIKCK--LIISIGGSNVNEYIDAVSKINDIPVMIELN 118
Query: 126 LSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGADG 185
+S P+ +G+G V E+VK VK + KPV KL P +I E+ A AGADG
Sbjct: 119 VSSPNRRGFGES---NLTYVEEIVKNVKSIVKKPVFVKLGP-WDNIVEIAGRALSAGADG 174
Query: 186 VSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIGGITT 245
++ INT+K + ID+ +PILS GG SG + +A+R ++D+ + +IG+GG+
Sbjct: 175 LTLINTLKGMLIDVEDFKPILSYGTGGISGKCIHALAVRVIHDVFKEYEPEIIGVGGVFD 234
Query: 246 WQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLALK 302
W+DA+E + GA + +GT + +GF V REI EGI YL+E+G V+EI G+ +K
Sbjct: 235 WRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGIGTYLEEKGL-KVEEIRGIGVK 290
>gb|AAK40921.1| Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase)
(pyrD) [Sulfolobus solfataricus]
Length = 290
Score = 173 bits (435), Expect = 2e-42
Identities = 103/297 (34%), Positives = 169/297 (56%), Gaps = 11/297 (3%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRR-AHREGAGGVVTKSIGMEPRKGYENPTIVELP 66
+ + I +PLI+ASG++ P + + + TK++ + P + ++ PT+++L
Sbjct: 2 ITIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKLH 61
Query: 67 YGL-INAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVADAFELN 125
G+ +NA+GL NPG +A E P+IVS+ G + E + E + A E+N
Sbjct: 62 DGIYMNAIGLGNPGAKAINEI----GVLCPLIVSVGGSSINEIKEVVEVVQSKAKIIEIN 117
Query: 126 LSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGADG 185
+S P+ KGYG + + + +++++VK VT PV KL P + I G A EK GADG
Sbjct: 118 VSSPNRKGYGESLSKL---IGDIIESVKSVTKLPVFVKLGPWDNVIELAGKALEK-GADG 173
Query: 186 VSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIGGITT 245
++ INT+K + ID+ +PIL GG SG + PIALR + D+ + +IG+GG+
Sbjct: 174 LTLINTIKGLIIDVETFKPILYYGTGGVSGRCLYPIALRIIKDVYEEYGVDIIGVGGVYD 233
Query: 246 WQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLALK 302
W D + L AGA + +GT + +GFSV EI +G+ YL E+G ++IIG++++
Sbjct: 234 WTDVIGMLAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKGL-KFEDIIGISVR 289
>sp|Q9UX04|PYRD_SULSO DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|6015863|emb|CAB57690.1| (Y18930)
dihydroorotate dehydrogenase (dihydroorotate oxidase)
(dhodehase) [Sulfolobus solfataricus]
Length = 290
Score = 173 bits (435), Expect = 2e-42
Identities = 103/297 (34%), Positives = 169/297 (56%), Gaps = 11/297 (3%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRR-AHREGAGGVVTKSIGMEPRKGYENPTIVELP 66
+ + I +PLI+ASG++ P + + + TK++ + P + ++ PT+++L
Sbjct: 2 ITIKNITLNDPLIIASGIIPDVPNYVETICEKYKPSAITTKTVTLNPLEPHKPPTVIKLH 61
Query: 67 YGL-INAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVADAFELN 125
G+ +NA+GL NPG +A E P+IVS+ G + E + E + A E+N
Sbjct: 62 DGIYMNAIGLGNPGAKAINEI----GVLCPLIVSVGGSSINEIKEVVEVVQSKAKIIEIN 117
Query: 126 LSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAGADG 185
+S P+ KGYG + + + +++++VK VT PV KL P + I G A EK GADG
Sbjct: 118 VSSPNRKGYGESLSKL---IGDIIESVKSVTKLPVFVKLGPWDNVIELAGKALEK-GADG 173
Query: 186 VSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSLDIPVIGIGGITT 245
++ INT+K + ID+ +PIL GG SG + PIALR + D+ + +IG+GG+
Sbjct: 174 LTLINTIKGLIIDVETFKPILYYGTGGVSGRCLYPIALRIIKDVYEEYGVDIIGVGGVYD 233
Query: 246 WQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLALK 302
W D + L AGA + +GT + +GFSV EI +G+ YL E+G ++IIG++++
Sbjct: 234 WTDVIGMLAAGAKLVGLGTVLIEKGFSVIEEIRKGLQSYLLEKGL-KFEDIIGISVR 289
>pir||F83590 probable oxidoreductase PA0439 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9946297|gb|AAG03828.1|AE004481_4
(AE004481) probable oxidoreductase [Pseudomonas
aeruginosa]
Length = 425
Score = 163 bits (409), Expect = 2e-39
Identities = 113/322 (35%), Positives = 163/322 (50%), Gaps = 30/322 (9%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPR--------KGY 57
L + GIK NP LAS + RA++ G GGVV K++G +P +
Sbjct: 5 LSIEFAGIKSPNPFWLASAPPTDKAYNVVRAYQAGWGGVVWKTLGEDPAAVNVSSRYSAH 64
Query: 58 ENPTIVELPYGLINAMGLPNPGWEAFLEEFRKEKFDFP---VIVSIFGGTPEE----FAF 110
P G+ N + + E L E + K D+P +IVS+ EE
Sbjct: 65 FGPN--RQVQGINNIELITDRSLEINLREIAQVKKDWPDRALIVSLMVPCVEESWKYILP 122
Query: 111 LAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPN 167
L E G AD ELN CPH +G G +GQ PE V V + K PVI KLTPN
Sbjct: 123 LVEATG--ADGIELNFGCPHGMPERGMGAAVGQVPEYVEMVTRWCKAHCSLPVIVKLTPN 180
Query: 168 VSDIRELGLAAEKAGADGVSAINTVKAIA---IDIYAKRPILSNK--FGGYSGPGVKPIA 222
++DIR+ AA + GAD VS INT+ +I ++ P++ + GGY G VKPIA
Sbjct: 181 ITDIRQSARAAHRGGADAVSLINTINSITSVDLERMVALPVVGTQSTHGGYCGSAVKPIA 240
Query: 223 LRAVYDLA---SSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAE 279
L V ++A + +P+ GIGGI +W+DA EF+ G A+Q+ TA L GF + ++ +
Sbjct: 241 LNMVAEIARDPQTRGLPICGIGGIGSWRDAAEFVALGCGAVQVCTAAMLHGFRIVEDMQD 300
Query: 280 GISRYLKEEGYSSVKEIIGLAL 301
G++R++ GY + + G A+
Sbjct: 301 GLARWMDSHGYQRLSDFSGGAV 322
>emb|CAA73354.1| (Y12823) dihydroorotate oxidase [Sulfolobus acidocaldarius]
Length = 265
Score = 158 bits (395), Expect = 9e-38
Identities = 94/260 (36%), Positives = 150/260 (57%), Gaps = 9/260 (3%)
Query: 44 VVTKSIGMEPRKGYENPTIVELPYGL-INAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFG 102
+ +K++ P + + +PT V++ +NA+GL NPG + L + + K +I+SI G
Sbjct: 13 ITSKTLTYSPLEPHRSPTFVKISDNCYLNAIGLGNPGIQ-ILRDLGEIKCK--LIISIGG 69
Query: 103 GTPEEFAFLAEKLGEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIA 162
E+ K+ ++ ELN+S P+ +G+G V E+VK VK + KPV
Sbjct: 70 SNVNEYIDAVSKINDIPVMIELNVSSPNRRGFGES---NLTYVEEIVKNVKSIVKKPVFV 126
Query: 163 KLTPNVSDIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIA 222
KL P +I E+ A AGADG++ INT+K + ID+ +PILS GG SG + +A
Sbjct: 127 KLGP-WDNIVEIAGRALSAGADGLTLINTLKGMLIDVEDFKPILSYGTGGISGKCIHALA 185
Query: 223 LRAVYDLASSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGIS 282
+R ++D+ + +IG+GG+ W+DA+E + GA + +GT + +GF V REI EGI
Sbjct: 186 VRVIHDVFKEYEPEIIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGIG 245
Query: 283 RYLKEEGYSSVKEIIGLALK 302
YL+E+G V+EI G+ +K
Sbjct: 246 TYLEEKGL-KVEEIRGIGVK 264
>sp|Q18164|DPYD_CAEEL PROBABLE DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] (DPD)
(DIHYDROURACIL DEHYDROGENASE) (DIHYDROTHYMINE
DEHYDROGENASE) >gi|7451559|pir||T15616 hypothetical
protein C25F6.3 - Caenorhabditis elegans
>gi|1049458|gb|AAA80433.1| (U39742) coded for by C.
elegans cDNA yk28e9.3; coded for by C. elegans cDNA
yk28e9.5; coded for by C. elegans cDNA yk28h9.3; coded
for by C. elegans cDNA yk28h9.5; coded for by C. elegans
cDNA yk40e4.5; coded for by C. elegans cDNA yk5h3.5;
weakly si>
Length = 1084
Score = 151 bits (378), Expect = 9e-36
Identities = 110/317 (34%), Positives = 163/317 (50%), Gaps = 30/317 (9%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEP-----------R 54
+ V++ G+KF+NP LAS + + RRA +G G ++TK+ G++ R
Sbjct: 572 ISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTNVSPRIVR 631
Query: 55 KGYENPTIVELPYGLINAMGLPNPGWEAFLEEFRKEKFDFP---VIVSIFGGTPE----E 107
P +N + E +L+ R+ K D P VI SI + E
Sbjct: 632 GSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVIASIMCVYNKADWIE 691
Query: 108 FAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKL 164
A +E+ G AD ELNLSCPH KG G+ GQ PE V E+ + V+ P K+
Sbjct: 692 LATKSEEAG--ADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRACVKIPFFPKM 749
Query: 165 TPNVSDIRELGLAAEKAGADGVSAINTVKAI---AIDIYAKRPILSNK---FGGYSGPGV 218
TPN++D+RE+ AA GA GV+A NTV ++ D A I S K +GG SG +
Sbjct: 750 TPNITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGSTKRTTYGGMSGSAI 809
Query: 219 KPIALRAVYDLASSLD-IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREI 277
+PIA++AV +A+ LD P++ GGI + + + FL+AGAS LQ+ +AV + F+V +
Sbjct: 810 RPIAMKAVSSIANELDGFPIMATGGIESAETGLGFLMAGASVLQVCSAVQNQDFTVVDDY 869
Query: 278 AEGISRYLKEEGYSSVK 294
G+ L G S+K
Sbjct: 870 CTGLKALLYLSGAESLK 886
>gb|AAF46461.2| (AE003446) Reg-3 gene product [Drosophila melanogaster]
Length = 1031
Score = 150 bits (376), Expect = 1e-35
Identities = 111/308 (36%), Positives = 165/308 (53%), Gaps = 30/308 (9%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYE-NPTIVE 64
+ V + GI+F+NP LAS + ++RRA +G G VVTK+ G++ +P IV
Sbjct: 528 ISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLVTNVSPRIVR 587
Query: 65 -----LPYG-----LINAMGLPNPGWEAFLEEFRKEKFDFP---VIVSIFGGTPEE---- 107
YG +N + E +L+ + K DFP VI SI EE
Sbjct: 588 GTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEEDWTE 647
Query: 108 FAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKL 164
A AE+ G ADA ELNLSCPH +G G+ GQ PE V ++ + V+ P KL
Sbjct: 648 LAIKAEQSG--ADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKL 705
Query: 165 TPNVSDIRELGLAAEKAGADGVSAINTVK---AIAIDIYAKRPILSNK---FGGYSGPGV 218
TPN++DI + AA++ GADG SAINTV+ + D A I + +GG SG
Sbjct: 706 TPNITDIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNAT 765
Query: 219 KPIALRAVYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREI 277
+P+AL+A+ D+A+ + P++GIGGI + + A++F+ AGA+ LQI ++V + F+V +
Sbjct: 766 RPMALKAISDIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDY 825
Query: 278 AEGISRYL 285
+ L
Sbjct: 826 CTALKALL 833
>sp|P54321|PYDA_LACLC DIHYDROOROTATE DEHYDROGENASE A (DIHYDROOROTATE OXIDASE A)
(DHODEHASE A) (DHODASE A) (DHOD A)
>gi|3660331|pdb|2DOR|A Chain A, Dihydroorotate
Dehydrogenase A From Lactococcus Lactis Complexed With
Orotate >gi|3660332|pdb|2DOR|B Chain B, Dihydroorotate
Dehydrogenase A From Lactococcus Lactis Complexed With
Orotate >gi|2098351|pdb|1DOR|A Chain A, Dihydroorotate
Dehydrogenase A From Lactococcus Lactis
>gi|2098352|pdb|1DOR|B Chain B, Dihydroorotate
Dehydrogenase A From Lactococcus Lactis
>gi|511015|emb|CAA52279.1| (X74206) dihydroorotate
dehydrogenase A [Lactococcus lactis]
Length = 311
Score = 145 bits (362), Expect = 6e-34
Identities = 109/314 (34%), Positives = 159/314 (49%), Gaps = 28/314 (8%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
ML KF NP + ASGV MT E L AG +TKS +E R+G P V+
Sbjct: 1 MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAYITKSSTLEKREGNPLPRYVD 60
Query: 65 LPYGLINAMGLPNPGWEAFLEEFRKEK----FDFPVIVSIFGGTPEEFAFLAEKLGE--V 118
L G IN+MGLPN G++ +L+ K + + P+ SI G + E + +K+ E
Sbjct: 61 LELGSINSMGLPNLGFDYYLDYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDF 120
Query: 119 ADAFELNLSCPHAKGYGMEIGQKPENVYE------VVKAVKDVTDKPVIAKLTPNVSDIR 172
+ ELNLSCP+ G KP+ Y+ ++K V KP+ KL P D+
Sbjct: 121 SGITELNLSCPNVPG-------KPQLAYDFEATEKLLKEVFTFFTKPLGVKLPP-YFDLV 172
Query: 173 ELGLAAEKAGADGVSAINTVKAIA----IDIYAKRPILSNK--FGGYSGPGVKPIALRAV 226
+ AE ++ +N+V +I ID A+ ++ K FGG G +KP AL V
Sbjct: 173 HFDIMAEILNQFPLTYVNSVNSIGNGLFIDPEAESVVIKPKDGFGGIGGAYIKPTALANV 232
Query: 227 YDLASSL--DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRY 284
+ L +I +IG GGI T QDA E LL GA+ LQIGTA++ G ++F I + +
Sbjct: 233 RAFYTRLKPEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPAIFDRIIKELEEI 292
Query: 285 LKEEGYSSVKEIIG 298
+ ++GY S+ + G
Sbjct: 293 MNQKGYQSIADFHG 306
>sp|Q28943|DPYD_PIG DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] PRECURSOR (DPD)
(DIHYDROURACIL DEHYDROGENASE) (DIHYDROTHYMINE
DEHYDROGENASE) >gi|1082961|pir||B54718 dihydropyrimidine
dehydrogenase (NADP+) (EC 1.3.1.2) - pig
>gi|558307|gb|AAA57475.1| (U09179) dihydropyrimidine
dehydrogenase [Sus scrofa]
Length = 1025
Score = 140 bits (349), Expect = 2e-32
Identities = 112/326 (34%), Positives = 162/326 (49%), Gaps = 43/326 (13%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
+ V + G+KF NP LAS + ++RRA G G +TK+ ++ K +
Sbjct: 533 ISVEMAGLKFINPFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSLD--KDIVTNVSPRI 590
Query: 66 PYGLINAMGLPNPGWEAFL--------------EEFRKEKFDFP---VIVSIFGGTPE-- 106
G + + PG +FL + + K DFP VI SI +
Sbjct: 591 VRGTTSGP-MYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKND 649
Query: 107 --EFAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVI 161
E + AE G ADA ELNLSCPH +G G+ GQ PE V + + V+ P
Sbjct: 650 WMELSRKAEASG--ADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFF 707
Query: 162 AKLTPNVSDIRELGLAAEKAGADGVSAINTV------KAIAIDIYAKRPILSNKFGGYSG 215
AKLTPNV+DI + AA++ GADGV+A NTV KA A +GG SG
Sbjct: 708 AKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGAGKRTTYGGVSG 767
Query: 216 PGVKPIALRAVYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVF 274
++PIALRAV +A +L P++ GGI + + ++FL +GAS LQ+ +AV + F+V
Sbjct: 768 TAIRPIALRAVTTIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVI 827
Query: 275 REIAEGISR--YLKEEGYSSVKEIIG 298
++ G+ YLK S++E+ G
Sbjct: 828 QDYCTGLKALLYLK-----SIEELQG 848
>gi|4503373 dihydropyrimidine dehydrogenase [Homo sapiens]
>gi|2498310|sp|Q12882|DPYD_HUMAN DIHYDROPYRIMIDINE
DEHYDROGENASE [NADP+] PRECURSOR (DPD) (DIHYDROURACIL
DEHYDROGENASE) (DIHYDROTHYMINE DEHYDROGENASE)
>gi|1082333|pir||A54718 dihydropyrimidine dehydrogenase
(NADP+) (EC 1.3.1.2) - human >gi|558305|gb|AAA57474.1|
(U09178) dihydropyrimidine dehydrogenase [Homo sapiens]
Length = 1025
Score = 139 bits (346), Expect = 5e-32
Identities = 106/314 (33%), Positives = 158/314 (49%), Gaps = 42/314 (13%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
+ V + G+KF NP LAS + ++RRA G G +TK+ ++ K +
Sbjct: 533 ISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLD--KDIVTNVSPRI 590
Query: 66 PYGLINAMGLPNPGWEAFL--------------EEFRKEKFDFP---VIVSIFGG-TPEE 107
G + + PG +FL + + K DFP VI SI +
Sbjct: 591 IRGTTSGP-MYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKND 649
Query: 108 FAFLAEKLGEV-ADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAK 163
+ LA+K + ADA ELNLSCPH +G G+ GQ PE V + + V+ P AK
Sbjct: 650 WTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAK 709
Query: 164 LTPNVSDIRELGLAAEKAGADGVSAINTVKAI-----------AIDIYAKRPILSNKFGG 212
LTPNV+DI + AA++ GA+GV+A NTV + A+ I AKR +GG
Sbjct: 710 LTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGI-AKR----TTYGG 764
Query: 213 YSGPGVKPIALRAVYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGF 271
SG ++PIALRAV +A +L P++ GGI + + ++FL +GAS LQ+ +A+ + F
Sbjct: 765 VSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDF 824
Query: 272 SVFREIAEGISRYL 285
+V + G+ L
Sbjct: 825 TVIEDYCTGLKALL 838
>gb|AAB51366.1| (U20938) No definition line found [Homo sapiens]
>gi|6729338|dbj|BAA89789.1| (AB003063) dihydropyrimidine
dehydrogenase [Homo sapiens]
Length = 1025
Score = 139 bits (346), Expect = 5e-32
Identities = 106/314 (33%), Positives = 158/314 (49%), Gaps = 42/314 (13%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
+ V + G+KF NP LAS + ++RRA G G +TK+ ++ K +
Sbjct: 533 ISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLD--KDIVTNVSPRI 590
Query: 66 PYGLINAMGLPNPGWEAFL--------------EEFRKEKFDFP---VIVSIFGG-TPEE 107
G + + PG +FL + + K DFP VI SI +
Sbjct: 591 IRGTTSGP-MYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKND 649
Query: 108 FAFLAEKLGEV-ADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAK 163
+ LA+K + ADA ELNLSCPH +G G+ GQ PE V + + V+ P AK
Sbjct: 650 WTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAK 709
Query: 164 LTPNVSDIRELGLAAEKAGADGVSAINTVKAI-----------AIDIYAKRPILSNKFGG 212
LTPNV+DI + AA++ GA+GV+A NTV + A+ I AKR +GG
Sbjct: 710 LTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGI-AKR----TTYGG 764
Query: 213 YSGPGVKPIALRAVYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGF 271
SG ++PIALRAV +A +L P++ GGI + + ++FL +GAS LQ+ +A+ + F
Sbjct: 765 VSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDF 824
Query: 272 SVFREIAEGISRYL 285
+V + G+ L
Sbjct: 825 TVIEDYCTGLKALL 838
>dbj|BAB02704.1| (AB019230) senescencs-related protein; dihydroorotate
dehydrogenase-like protein [Arabidopsis thaliana]
Length = 426
Score = 139 bits (346), Expect = 5e-32
Identities = 100/330 (30%), Positives = 164/330 (49%), Gaps = 35/330 (10%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYE-NPTIVE 64
L V + G+K NP ++ SG +++RA EG G V+ K++ ++ K P
Sbjct: 52 LSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLDASKVINVTPRYAR 111
Query: 65 LPYGLINAMGLPNPGW-----------EAFLEEFRKEKFDFP---VIVSI---FGGTP-E 106
L G + GW E L+EF + K ++P +I S+ + T E
Sbjct: 112 LRTGSNGSAKTDVIGWQNIELISDRPLETMLKEFERLKKEYPDRILIASVMEEYNKTAWE 171
Query: 107 EFAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAK 163
E E+ G DA E+N SCPH + G +GQ + EV + PV AK
Sbjct: 172 ELIDRVEQTG--VDALEINFSCPHGMPERRMGAAVGQDCALLDEVCGWINAKATVPVWAK 229
Query: 164 LTPNVSDIRELGLAAEKAGADGVSAINTVKAI-AIDIYAKRPILS----NKFGGYSGPGV 218
+TPN++DI E + K+G +G++AINT+ ++ ID+ RP + GGYS V
Sbjct: 230 MTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDMKTLRPEPCVEGYSTPGGYSYKAV 289
Query: 219 KPIALRAVYDLASSL------DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFS 272
+PIAL V ++A + D + GIGG+ T DA EF+L G++ +Q+ T V + G+
Sbjct: 290 RPIALAKVMNIAKMMKSEFSEDRSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMMHGYG 349
Query: 273 VFREIAEGISRYLKEEGYSSVKEIIGLALK 302
+ + + ++K+ +S+++E G +L+
Sbjct: 350 HVKTLCAELKDFMKQHNFSTIEEFRGHSLQ 379
>gb|AAC47288.1| (U65491) Dreg-3 protein [Drosophila melanogaster]
Length = 626
Score = 136 bits (338), Expect = 4e-31
Identities = 111/318 (34%), Positives = 165/318 (50%), Gaps = 33/318 (10%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYE-NPTIVE 64
+ V + GI+F+NP LAS + ++RRA +G G VVTK+ G++ +P IV
Sbjct: 124 ISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLVTNVSPRIVR 183
Query: 65 -----LPYG-----LINAMGLPNPGWEAFLEEFRKEKFDFP---VIVSIFGGTPEE---- 107
YG +N + E +L+ + K DFP VI SI EE
Sbjct: 184 GTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEEDWTE 243
Query: 108 FAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKL 164
A AE+ G ADA ELNLSCPH +G G+ GQ PE V ++ + V+ P KL
Sbjct: 244 LAIKAEQSG--ADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKL 301
Query: 165 TPNVSDIRELGLAAEKAGADGVSAINTVK---AIAIDIYAKRPILSNK---FGGYSGPGV 218
TPN++DI + AA K SAINTV+ + D A I + +GG SG
Sbjct: 302 TPNITDIVSIA-AAAKREEPMRSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNAT 360
Query: 219 KPIALRAVYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREI 277
+P+AL+A+ D+A+ + P++GIGGI + + A++F+ AGA+ LQI ++V + F+V +
Sbjct: 361 RPMALKAISDIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDY 420
Query: 278 AEGISR--YLKEEGYSSV 293
+ YLK + S+
Sbjct: 421 CTALKALLYLKRIRHQSM 438
>sp|Q9X9S0|PYRD_STRPN DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|5578893|emb|CAB51330.1| (AJ131985)
dihydroorotate dehydrogenase [Streptococcus pneumoniae]
Length = 311
Score = 136 bits (338), Expect = 4e-31
Identities = 99/305 (32%), Positives = 153/305 (49%), Gaps = 17/305 (5%)
Query: 7 EVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELP 66
+ + G +F N L+ A+GV MT E L AG VTK+ ++ R+G P ++P
Sbjct: 5 KTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRYQDVP 64
Query: 67 YGLINAMGLPNPGWEAFLE---EFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGE--VADA 121
G IN+MGLPN G + +L+ + ++++ + +S+ G +PEE + +K+ E
Sbjct: 65 LGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLVGMSPEETHTILKKVQESDFRGL 124
Query: 122 FELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKA 181
ELNLSCP+ G +I E ++ V KP+ KL P DI AA
Sbjct: 125 TELNLSCPNVPG-KPQIAYDFETTDRILAEVFAYFTKPLGIKLPP-YFDIVYFDQAAAIF 182
Query: 182 GADGVSAINTVKAIAIDIYAK------RPILSNKFGGYSGPGVKPIALRAVYDLASSLD- 234
+ +N V +I +Y + RP N FGG G +KP AL V+ L+
Sbjct: 183 NKYPLKFVNCVNSIGNGLYIEDESVVIRP--KNGFGGIGGEYIKPTALANVHAFYQRLNP 240
Query: 235 -IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSV 293
I +IG GG+ T +DA E +L GAS +Q+GT ++ G S F I + + E+GY S+
Sbjct: 241 QIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESL 300
Query: 294 KEIIG 298
++ G
Sbjct: 301 EDFRG 305
>dbj|BAA33218.1| (D85035) dihydropyrimidine dehydrogenase [Rattus norvegicus]
Length = 1025
Score = 135 bits (337), Expect = 6e-31
Identities = 103/309 (33%), Positives = 152/309 (48%), Gaps = 32/309 (10%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
+ V + G++F NP LAS + ++RRA G G +TK+ ++ K +
Sbjct: 533 ISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLD--KDIVTNVSPRI 590
Query: 66 PYGLINAMGLPNPGWEAFLE--------------EFRKEKFDFP---VIVSIFGGTPEEF 108
G + L PG +FL + K DFP +I SI +
Sbjct: 591 IRGTTSGP-LYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKND 649
Query: 109 AFLAEKLGEV--ADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAK 163
K+ E ADA ELNLSCPH +G G+ GQ PE V + + V+ P AK
Sbjct: 650 WMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFAK 709
Query: 164 LTPNVSDIRELGLAAEKAGADGVSAINTVK---AIAIDIYAKRPILSNK---FGGYSGPG 217
LTPNV+DI + AA++ GADGV+A NTV + D + S K +GG SG
Sbjct: 710 LTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGSPWPSVGSGKRTTYGGVSGTT 769
Query: 218 VKPIALRAVYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFRE 276
++PIALRAV +A +L P++ GGI + + ++FL +GAS LQ+ +A+ + F+V +
Sbjct: 770 IRPIALRAVTAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIED 829
Query: 277 IAEGISRYL 285
G+ L
Sbjct: 830 YCTGLKALL 838
>dbj|BAA86060.1| (AB014457) senescencs-related protein [Pyrus pyrifolia]
Length = 424
Score = 134 bits (335), Expect = 1e-30
Identities = 100/331 (30%), Positives = 161/331 (48%), Gaps = 36/331 (10%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYE-NPTIVE 64
L V + G+ NP ++ SG +++RA EG G V+ K++ +E K P
Sbjct: 49 LSVTVNGLHMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLEADKVKNVTPRYAR 108
Query: 65 LPYGLINAMGLPNPGWE-----------AFLEEFRKEKFDFP---VIVSIFGGTP----E 106
L + GWE L+EF++ K ++P +I SI E
Sbjct: 109 LRVDGNGSAKGQIIGWENIELISDRPLDIMLKEFKQLKQEYPDRILIASIMEEYNKAGWE 168
Query: 107 EFAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVIAK 163
E E+ G DA E+N SCPH + G +GQ + EV + PV AK
Sbjct: 169 ELIDRVEQTG--VDALEINFSCPHGMPERKMGAAVGQDCALLEEVCGWINAKATVPVWAK 226
Query: 164 LTPNVSDIRELGLAAEKAGADGVSAINTVKAI-AIDIYAKRPILS----NKFGGYSGPGV 218
+TPN++DI + A +G +GVSAINT+ ++ I++ RP + GGYS V
Sbjct: 227 MTPNITDITQPARVALSSGCEGVSAINTIMSVMGINLTTLRPEPCVEGYSTPGGYSAKAV 286
Query: 219 KPIALRAVYDLASSL-------DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGF 271
PIAL V ++A + D + GIGG+ + DA EF+L GA+ +Q+ T V + G+
Sbjct: 287 HPIALAKVMNIAKLMKSEFGDTDYSLSGIGGVESGGDAAEFILLGANTVQVCTGVMMHGY 346
Query: 272 SVFREIAEGISRYLKEEGYSSVKEIIGLALK 302
V +++ + ++K+ +SS+++ G +L+
Sbjct: 347 GVVKKLCSELQDFMKQHNFSSIEDFRGASLE 377
>sp|Q28007|DPYD_BOVIN DIHYDROPYRIMIDINE DEHYDROGENASE [NADP+] (DPD) (DIHYDROURACIL
DEHYDROGENASE) (DIHYDROTHYMINE DEHYDROGENASE)
>gi|677951|gb|AAB40985.1| (U20981) dihydropyrimidine
dehydrogenase [Bos taurus]
Length = 1025
Score = 132 bits (328), Expect = 6e-30
Identities = 102/311 (32%), Positives = 151/311 (47%), Gaps = 36/311 (11%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
+ V + +KF NP LAS + ++RRA G +TK+ ++ K +
Sbjct: 533 ISVEMAALKFTNPFGLASATPTTSSSMIRRAFEAGWAFALTKTFSLD--KDIVTNVSPRI 590
Query: 66 PYGLINAMGLPNPGWEAFL--------------EEFRKEKFDFP---VIVSIFGGTPE-- 106
G + + PG +FL + + K DFP VI SI
Sbjct: 591 IRGTTSGP-MYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNRND 649
Query: 107 --EFAFLAEKLGEVADAFELNLSCPHA---KGYGMEIGQKPENVYEVVKAVKDVTDKPVI 161
E + AE G ADA ELNLSCPH +G G+ GQ PE V + + V+ P
Sbjct: 650 WMELSRKAEASG--ADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRIPFF 707
Query: 162 AKLTPNVSDIRELGLAAEKAGADGVSAINTV------KAIAIDIYAKRPILSNKFGGYSG 215
AKLTPNV+DI + AA++ GA+GV+A NTV KA A +GG SG
Sbjct: 708 AKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKADGTPWPAVGREKRTTYGGVSG 767
Query: 216 PGVKPIALRAVYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVF 274
++PIALRAV +A +L + P++ GGI + + ++FL GAS LQ+ +A+ + F++
Sbjct: 768 TAIRPIALRAVTTIARALPEFPILATGGIDSAESGLQFLHGGASVLQVCSAIQNQDFTII 827
Query: 275 REIAEGISRYL 285
++ G+ L
Sbjct: 828 QDYCTGLKALL 838
>sp|Q9WYG8|PYRD_THEMA DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7462365|pir||G72390 dihydroorotate
dehydrogenase - Thermotoga maritima (strain MSB8)
>gi|4980834|gb|AAD35420.1|AE001714_11 (AE001714)
dihydroorotate dehydrogenase [Thermotoga maritima]
Length = 270
Score = 131 bits (327), Expect = 8e-30
Identities = 91/280 (32%), Positives = 149/280 (52%), Gaps = 19/280 (6%)
Query: 13 IKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELPYGLINA 72
++ K PL+L SG L HR GGV+ K++ + P++G P + + + +IN
Sbjct: 2 LELKPPLVLLSGPAGFGEYLKLMDHRY-VGGVLLKTVTLHPKEGNPTPRMADSDFYVINR 60
Query: 73 MGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEVADAF---ELNLSCP 129
+GL NPG AF+E + P+I S+ G + EE+ +A +VAD F E N SCP
Sbjct: 61 IGLENPGIHAFVENI--PELPVPMIASLGGDSFEEYLEVARVFKKVADRFYAVEFNFSCP 118
Query: 130 HAKGYGMEIGQKPENVYEVVKAV-KDVTDKPVIAKLTPNVSDIRELGLAAEKAGADGVSA 188
+ K G+ I + E +++ + K++ D +IAK+ + + K G DG++
Sbjct: 119 NVKEGGLSIVKNAEEWKKLLNTLRKELPDSFLIAKVGVEGIFVEDAAEFVMKTGWDGITL 178
Query: 189 INTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSL-DIPVIGIGGITTWQ 247
+NTV+ + + K ++ GG SGP +KPIALRAVY++ ++ VI GG+ + +
Sbjct: 179 VNTVRGLH---FEKDTMI---LGGLSGPVLKPIALRAVYEVKKRFPELFVIASGGVYSVK 232
Query: 248 DAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKE 287
DA EFL GA + +G+A++ + E I +YL E
Sbjct: 233 DAEEFLKVGADVIGVGSALFKD-----PGVVEEIGKYLLE 267
>gi|6322633 dihydroorotate dehydrogenase; Ura1p [Saccharomyces cerevisiae]
>gi|131723|sp|P28272|PYRD_YEAST DIHYDROOROTATE
DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
>gi|101280|pir||JC1276 dihydroorotate oxidase (EC
1.3.3.1) - yeast (Saccharomyces cerevisiae)
>gi|4754|emb|CAA42014.1| (X59371) dihydroorotate
oxidase [Saccharomyces cerevisiae]
>gi|171394|gb|AAA34566.1| (M83295) dihydroorotic acid
dehydrogenase [Saccharomyces cerevisiae]
>gi|473134|emb|CAA53557.1| (X75951) URA1 [Saccharomyces
cerevisiae] >gi|486387|emb|CAA82061.1| (Z28216) ORF
YKL216w [Saccharomyces cerevisiae]
Length = 314
Score = 129 bits (321), Expect = 4e-29
Identities = 98/304 (32%), Positives = 148/304 (48%), Gaps = 28/304 (9%)
Query: 15 FKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELPYGLINAMG 74
++NP + ASGV MT + L AG +TKS R+G P + +P G IN+MG
Sbjct: 14 YENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMG 73
Query: 75 LPNPGWEAFLEEFRKEKFDFP----VIVSIFGGTPEEFAFLAEKL--GEVADAFELNLSC 128
LPN G + +L + ++P + S+ G + +E L K+ E ELNLSC
Sbjct: 74 LPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSC 133
Query: 129 PHAKGYGMEIGQKPENVY------EVVKAVKDVTDKPVIAKLTPNVSDIRELGLAAEKAG 182
P+ G KP+ Y E ++ V KP+ KL P D + A+
Sbjct: 134 PNVPG-------KPQVAYDFDLTKETLEKVFAFFKKPLGVKLPP-YFDFAHFDIMAKILN 185
Query: 183 ADGVSAINTVKAIA----IDIYAKRPIL--SNKFGGYSGPGVKPIALRAVYDLASSL--D 234
++ +N++ +I ID+ + ++ N FGG G VKP AL V + L +
Sbjct: 186 EFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPE 245
Query: 235 IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVK 294
I VIG GGI + +DA E LL GAS LQIGT + G +F I + + ++ +GY+S+
Sbjct: 246 IKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSID 305
Query: 295 EIIG 298
+ G
Sbjct: 306 QFRG 309
>pir||T30523 dihydroorotate dehydrogenase (EC 1.3.99.11) - Trypanosoma cruzi
>gi|3298143|dbj|BAA31360.1| (AB010286) dihydroorotate
oxidase [Trypanosoma cruzi] >gi|4210458|dbj|BAA74526.1|
(AB017765) DHODase [Trypanosoma cruzi]
Length = 314
Score = 120 bits (299), Expect = 2e-26
Identities = 98/314 (31%), Positives = 151/314 (47%), Gaps = 30/314 (9%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L++NL F NP + A+GV+ T E LR +G +V+KS PR G P +
Sbjct: 4 LKLNLLDHVFANPFMNAAGVLCSTEEDLRCMTASSSGALVSKSCTSAPRDGNPEPRYMAF 63
Query: 66 PYGLINAMGLPNPGWEAFLEEFRKEKFDF---PVIVSIFGGTPEEFAFLAEKLGEVADA- 121
P G IN+MGLPN G++ +L ++ + D+ P+ +SI G + EE + +L VA
Sbjct: 64 PLGSINSMGLPNLGFDFYL-KYASDLHDYSKKPLFLSISGLSVEENVAMVRRLAPVAQGK 122
Query: 122 ---FELNLSCPHAKGYGMEIGQKPENVYE------VVKAVKDVTDKPVIAKLTPNVSDIR 172
ELNLSCP+ G KP+ Y+ ++ V P K+ P DI
Sbjct: 123 GVLLELNLSCPNVPG-------KPQGAYDFEAMRTYLQQVSLAYGLPFGVKMPP-YFDIA 174
Query: 173 ELGLAA----EKAGADGVSAINTV-KAIAIDIYAKRPILSNK--FGGYSGPGVKPIALRA 225
AA E V+ +N+V + ID ++ ++ K FGG G + P AL
Sbjct: 175 HFDTAAAVLNEFPLVKFVTCVNSVGNGLVIDAESESVVIKPKQGFGGLGGKYILPTALAN 234
Query: 226 VYDLASSL-DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRY 284
V D V G GG+ + +DA +LAGAS +Q+GTA+ G +F + + +
Sbjct: 235 VNAFYRRCPDKLVFGCGGVYSGEDAFLHILAGASMVQVGTALQEEGPGIFTRLEDELLEI 294
Query: 285 LKEEGYSSVKEIIG 298
+ +GY +++E G
Sbjct: 295 MARKGYRTLEEFRG 308
>gb|AAG20569.1| (AE005127) dihydroorotate dehydrogenase; PyrD [Halobacterium sp.
NRC-1]
Length = 349
Score = 120 bits (298), Expect = 2e-26
Identities = 91/311 (29%), Positives = 151/311 (48%), Gaps = 24/311 (7%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L V+ FG F NP+ +A+G D E+ R G G + ++ E + G + P + L
Sbjct: 48 LSVDAFGQTFPNPVGMAAGF-DKNAEIPRALAGLGFGHIEVGAVTAERQPGNDRPRLFRL 106
Query: 66 P--YGLINAMGLPNPGWEAFLEEFRKEKF-DFPVIVSI-------FGGTPEEFAFLAEKL 115
P L+N MG N G + E D PV V+I P+++ + ++
Sbjct: 107 PDDNALVNRMGFNNEGADTVGARLDAEPLPDVPVGVNIGKSKTTPLADAPDDYTYTFSRV 166
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPN-----VSD 170
G+ D +N+S P+ G G+ + + +++A++D P++ KL+P+ V+D
Sbjct: 167 GDAVDYVVVNVSSPNTPGLRELQGR--DQLAAILEALQDAGASPLLVKLSPDLHQDAVAD 224
Query: 171 IRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLA 230
EL A G DG+ A NT + + + GG SG ++ A V +A
Sbjct: 225 AVEL---ANDLGLDGIVATNTTTERPESLSHPH---AGEQGGLSGAPIRERATEQVRFVA 278
Query: 231 SSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGY 290
D PV+G+GG+ T +DA E + AGAS +Q+ TA+ G V + I EG+ L+ +G+
Sbjct: 279 ERTDQPVVGVGGVATAEDAYEKIRAGASVVQLYTALVYEGPWVAKRINEGLVSLLERDGF 338
Query: 291 SSVKEIIGLAL 301
SV++ +G L
Sbjct: 339 DSVEDAVGADL 349
>dbj|BAA94299.1| (AB029444) Dihydroorotate dehydrogenase [Leishmania mexicana
amazonensis]
Length = 313
Score = 110 bits (273), Expect = 2e-23
Identities = 93/308 (30%), Positives = 145/308 (46%), Gaps = 18/308 (5%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L+VNL F NP + A+GV+ T E L +G +V+KS R+G P L
Sbjct: 3 LQVNLLNNTFANPFMNAAGVMCSTMEDLVAMTESASGSLVSKSCTPALREGNPTPRYRAL 62
Query: 66 PYGLINAMGLPNPGWEAFLEEFRKEKFDF---PVIVSIFGGTPEEFAFLAEKLGEVAD-- 120
P G IN+MGLPN G + F + E+ D+ P+ +S+ G + E A + ++L VA
Sbjct: 63 PLGSINSMGLPNNGLD-FYMAYAAEQHDYGKKPLFLSMSGLSVRENAEMCKRLAAVATEK 121
Query: 121 --AFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSDIRELGLAA 178
ELNLSCP+ G ++ + + + AV K+ P D AA
Sbjct: 122 GVILELNLSCPNVPGKA-QVAYDFDAMRQCFTAVSGGLPHSFGVKMPP-YFDFAHFDAAA 179
Query: 179 EKAG----ADGVSAINTV-KAIAIDIYAKRPILSNK--FGGYSGPGVKPIALRAVYDLAS 231
E ++ IN++ + ID + ++ K FGG G + P AL V
Sbjct: 180 EILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGHYILPTALANVNAFYR 239
Query: 232 SLDIPVI-GIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGY 290
+I G GG+ T +DA +LAGAS +Q+GTA+ G ++F + + + ++GY
Sbjct: 240 RCPEKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPAIFERLTSELLSVMAKKGY 299
Query: 291 SSVKEIIG 298
++ E G
Sbjct: 300 QTLDEFRG 307
>pir||I51850 dihydroorotate oxidase (EC 1.3.3.1) - black rat
Length = 395
Score = 104 bits (258), Expect = 1e-21
Identities = 83/318 (26%), Positives = 150/318 (47%), Gaps = 28/318 (8%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLEV + G KF+NP+ +A+G D E + ++ G G V S+ +P++G P +
Sbjct: 77 MLEVKVLGHKFRNPVGIAAGF-DKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFR 135
Query: 65 LP--YGLINAMGLPNPGWEAFLEEFRKEKFD--------FPVIVSIFGGTPEE-----FA 109
LP +IN G + G R + P+ +++ E +A
Sbjct: 136 LPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYA 195
Query: 110 FLAEKLGEVADAFELNLSCPHAKGYGM-----EIGQKPENVYEVVKAVKDVTDKPVIAKL 164
LG +AD +N+S P+ G E+ V + A+K V+ K+
Sbjct: 196 EGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKI 255
Query: 165 TPNVS--DIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIA 222
P+++ D ++ A + G DG+ NT + + + L ++ GG SG ++ ++
Sbjct: 256 APDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGA---LRSETGGLSGKPLRDLS 312
Query: 223 LRAVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEG 280
+ + ++ + IP+IG+GG+++ QDA+E + AGAS +Q+ TA+ G V +
Sbjct: 313 TQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRE 372
Query: 281 ISRYLKEEGYSSVKEIIG 298
+ LKE G+++V + IG
Sbjct: 373 LEALLKERGFTTVTDAIG 390
>sp|Q63707|PYRD_RAT DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIHYDROOROTATE OXIDASE)
>gi|11252399|pir||S47435 dihydroorotate oxidase (EC
1.3.3.1) - rat >gi|4379422|emb|CAA56765.1| (X80778)
dihydroorotate dehydrogenase [Rattus rattus]
Length = 395
Score = 104 bits (258), Expect = 1e-21
Identities = 83/318 (26%), Positives = 150/318 (47%), Gaps = 28/318 (8%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLEV + G KF+NP+ +A+G D E + ++ G G V S+ +P++G P +
Sbjct: 77 MLEVKVLGHKFRNPVGIAAGF-DKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFR 135
Query: 65 LP--YGLINAMGLPNPGWEAFLEEFRKEKFD--------FPVIVSIFGGTPEE-----FA 109
LP +IN G + G R + P+ +++ E +A
Sbjct: 136 LPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYA 195
Query: 110 FLAEKLGEVADAFELNLSCPHAKGYGM-----EIGQKPENVYEVVKAVKDVTDKPVIAKL 164
LG +AD +N+S P+ G E+ V + A+K V+ K+
Sbjct: 196 EGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKI 255
Query: 165 TPNVS--DIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIA 222
P+++ D ++ A + G DG+ NT + + + L ++ GG SG ++ ++
Sbjct: 256 APDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGA---LRSETGGLSGKPLRDLS 312
Query: 223 LRAVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEG 280
+ + ++ + IP+IG+GG+++ QDA+E + AGAS +Q+ TA+ G V +
Sbjct: 313 TQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRE 372
Query: 281 ISRYLKEEGYSSVKEIIG 298
+ LKE G+++V + IG
Sbjct: 373 LEALLKERGFTTVTDAIG 390
>gi|9910194 dihydroorotate dehydrogenase [Mus musculus]
>gi|8784074|gb|AAB82948.2| (AF029667) dihydroorotate
dehydrogenase [Mus musculus]
Length = 395
Score = 102 bits (252), Expect = 5e-21
Identities = 86/322 (26%), Positives = 151/322 (46%), Gaps = 34/322 (10%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLEV + G KF+NP+ +A+G D E + ++ G G V S+ +P++G P +
Sbjct: 77 MLEVRVLGHKFRNPVGIAAGF-DKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFR 135
Query: 65 LP--YGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTP---------------EE 107
LP +IN G + G A R + + + G P +
Sbjct: 136 LPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTT--DGLPLGINLGKNKTSVDAAAD 193
Query: 108 FAFLAEKLGEVADAFELNLSCPHAKGYGM-----EIGQKPENVYEVVKAVKDVTDKPVIA 162
+ LG +AD +N+S P+ G E+ + V + A+K V+
Sbjct: 194 YVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLV 253
Query: 163 KLTPNVS--DIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKP 220
K+ P+++ D ++ A + G DG+ NT + + + L ++ GG SG ++
Sbjct: 254 KIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGA---LRSETGGLSGKPLRD 310
Query: 221 IA---LRAVYDLASSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREI 277
++ +R +Y L IP+IG+GG+++ QDA+E + AGAS +Q+ TA+ G V +
Sbjct: 311 LSTQTIREMYALTQGT-IPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARV 369
Query: 278 AEGISRYLKEEGYSSVKEIIGL 299
+ LKE G+++V + IG+
Sbjct: 370 KRELEALLKERGFNTVTDAIGV 391
>sp|Q02127|PYRD_HUMAN DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIHYDROOROTATE OXIDASE)
>gi|2135000|pir||S62653 dihydroorotate oxidase (EC
1.3.3.1) - human (fragment) >gi|555594|gb|AAA50163.1|
(M94065) dihydroorotate dehydrogenase [Homo sapiens]
Length = 396
Score = 99.5 bits (244), Expect = 4e-20
Identities = 81/318 (25%), Positives = 151/318 (47%), Gaps = 28/318 (8%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLEV + G KF+NP+ +A+G D E + ++ G G V S+ +P++G P +
Sbjct: 78 MLEVRVLGHKFRNPVGIAAGF-DKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFR 136
Query: 65 LP--YGLINAMGLPNPGWEAFLEEFRKEKFD--------FPVIVSIFGG-----TPEEFA 109
LP +IN G + G R + P+ V++ E++A
Sbjct: 137 LPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYA 196
Query: 110 FLAEKLGEVADAFELNLSCPHAKGYGM-----EIGQKPENVYEVVKAVKDVTDKPVIAKL 164
LG +AD +N+S P+ G E+ + V + ++ V V+ K+
Sbjct: 197 EGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKI 256
Query: 165 TPNVS--DIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIA 222
P+++ D ++ ++ G DG+ NT + + L ++ GG SG ++ ++
Sbjct: 257 APDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGA---LRSETGGLSGKPLRDLS 313
Query: 223 LRAVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEG 280
+ + ++ + +P+IG+GG+++ QDA+E + AGAS +Q+ TA+ G V ++
Sbjct: 314 TQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRE 373
Query: 281 ISRYLKEEGYSSVKEIIG 298
+ LKE+G+ V + IG
Sbjct: 374 LEALLKEQGFGGVTDAIG 391
>pdb|1D3G|A Chain A, Human Dihydroorotate Dehydrogenase Complexed With
Brequinar Analog >gi|10835816|pdb|1D3H|A Chain A, Human
Dihydroorotate Dehydrogenase Complexed With
Antiproliferative Agent A771726
Length = 367
Score = 99.5 bits (244), Expect = 4e-20
Identities = 81/318 (25%), Positives = 151/318 (47%), Gaps = 28/318 (8%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLEV + G KF+NP+ +A+G D E + ++ G G V S+ +P++G P +
Sbjct: 49 MLEVRVLGHKFRNPVGIAAGF-DKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFR 107
Query: 65 LP--YGLINAMGLPNPGWEAFLEEFRKEKFD--------FPVIVSIFGG-----TPEEFA 109
LP +IN G + G R + P+ V++ E++A
Sbjct: 108 LPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYA 167
Query: 110 FLAEKLGEVADAFELNLSCPHAKGYGM-----EIGQKPENVYEVVKAVKDVTDKPVIAKL 164
LG +AD +N+S P+ G E+ + V + ++ V V+ K+
Sbjct: 168 EGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKI 227
Query: 165 TPNVS--DIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIA 222
P+++ D ++ ++ G DG+ NT + + L ++ GG SG ++ ++
Sbjct: 228 APDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGA---LRSETGGLSGKPLRDLS 284
Query: 223 LRAVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEG 280
+ + ++ + +P+IG+GG+++ QDA+E + AGAS +Q+ TA+ G V ++
Sbjct: 285 TQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRE 344
Query: 281 ISRYLKEEGYSSVKEIIG 298
+ LKE+G+ V + IG
Sbjct: 345 LEALLKEQGFGGVTDAIG 362
>sp|O06236|PYRD_MYCTU DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431643|pir||G70577 probable
dihydroorotate dehydrogenase - Mycobacterium
tuberculosis (strain H37RV) >gi|2104339|emb|CAB08654.1|
(Z95388) pyrD [Mycobacterium tuberculosis]
Length = 357
Score = 98.7 bits (242), Expect = 8e-20
Identities = 91/312 (29%), Positives = 143/312 (45%), Gaps = 24/312 (7%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
+L +FG++F PL LA+G D L G G ++ P+ G P +
Sbjct: 48 VLASTVFGVRFPAPLGLAAGF-DKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFR 106
Query: 65 LP--YGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSI-------FGGTPEEFAFLAEKL 115
L L+N MG N G A + + + P+ V+I G ++ A +
Sbjct: 107 LADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMV 166
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSD--IRE 173
G +A +N+S P+ G + Q E++ ++ AV+ T PV+ K+ P++SD + +
Sbjct: 167 GPLASYLVVNVSSPNTPG--LRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDD 224
Query: 174 LGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSL 233
+ A + G+ A NT ++ D + GG SGP P+A RAV L
Sbjct: 225 IADLAVELDLAGIVATNTT--VSRDGLTTPGVDRLGPGGISGP---PLAQRAVQVLRRLY 279
Query: 234 D-----IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEE 288
D + +I +GGI T DA E + AGAS LQ T G ++I EGI+R L +
Sbjct: 280 DRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDG 339
Query: 289 GYSSVKEIIGLA 300
G+ S+ E +G A
Sbjct: 340 GFGSLHEAVGSA 351
>pir||JN0500 dihydroorotate oxidase (EC 1.3.3.1), mitochondrial - fruit fly
(Drosophila melanogaster) >gi|7299059|gb|AAF54260.1|
(AE003679) Dhod gene product [Drosophila melanogaster]
Length = 405
Score = 98.3 bits (241), Expect = 1e-19
Identities = 87/316 (27%), Positives = 155/316 (48%), Gaps = 28/316 (8%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L + FG NP+ +A+G D E + G G + ++ ++G P + L
Sbjct: 86 LHTSFFGRMLSNPIGIAAGF-DKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRL 144
Query: 66 PY--GLINAMGLPNPGWEAFLEEFR----KEKFDFPVIVSIFGGTPEEFAFLAEKL---- 115
+IN G + G +A L+ R KE F+ V V++ G + +A+ +
Sbjct: 145 TEDKAIINRYGFNSDGHQAVLQRLRLLRKKENFNGVVGVNL-GRNKTTMSPIADYVQGVR 203
Query: 116 --GEVADAFELNLSCPHAKGY-GMEIGQKPENVYEVVKAVKDVTDK----PVIAKLTPNV 168
G VAD +N+S P+ KG M+ +K + E V K DK P++ KL+P++
Sbjct: 204 VFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLKLSPDL 263
Query: 169 S--DIRELG--LAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALR 224
S D++++ + +K+ DG+ NT ++ + K L+ + GG SGP +K +
Sbjct: 264 SLDDMKDIVWVIKRKKSRVDGLIVSNTT--VSRENIEKNK-LAEETGGLSGPPLKARSTE 320
Query: 225 AVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGIS 282
+ + D IP+IG+GG+ + DA E + AGAS +QI TA+ G ++ +I +S
Sbjct: 321 MIAQMYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAELS 380
Query: 283 RYLKEEGYSSVKEIIG 298
+ G+++V +++G
Sbjct: 381 ALITRLGHTNVADVVG 396
>pir||PC1219 dihydroorotate oxidase (EC 1.3.3.1) precursor - human
Length = 397
Score = 96.3 bits (236), Expect = 4e-19
Identities = 80/318 (25%), Positives = 150/318 (47%), Gaps = 28/318 (8%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
MLEV + G KF+NP+ +A+G D E + ++ G G V S+ +P++G P +
Sbjct: 79 MLEVRVLGHKFRNPVGIAAGF-DKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFR 137
Query: 65 LP--YGLINAMGLPNPGWEAFLEEFRKEKFD--------FPVIVSIFGG-----TPEEFA 109
LP +IN G + G R + P+ V++ E++A
Sbjct: 138 LPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYA 197
Query: 110 FLAEKLGEVADAFELNLSCPHAKGYGMEIGQKP-----ENVYEVVKAVKDVTDKPVIAKL 164
LG +AD +N+S P+ G G+ V + ++ V V+ K+
Sbjct: 198 EGVRVLGPLADYLVVNVSSPNTAGLRSLQGKADVRRLLTKVLQERDGLRRVHRPAVLVKI 257
Query: 165 TPNVS--DIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIA 222
P+++ D ++ ++ G DG+ NT + + L ++ GG SG ++ ++
Sbjct: 258 APDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGA---LRSETGGLSGKPLRDLS 314
Query: 223 LRAVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEG 280
+ + ++ + +P+IG+GG+++ Q+A+E + AGAS +Q+ TA+ G V ++
Sbjct: 315 TQTIREMYALTQGRVPIIGVGGVSSGQNALEKIRAGASLVQLYTALPFWGPPVVGKVKRE 374
Query: 281 ISRYLKEEGYSSVKEIIG 298
+ LKE+G+ V + IG
Sbjct: 375 LEALLKEQGFGGVTDAIG 392
>pir||S72881 dihydroorotate oxidase (EC 1.3.3.1) - Mycobacterium leprae
>gi|467036|gb|AAA17221.1| (U00017) pyrD; B2126_F3_143
[Mycobacterium leprae]
Length = 309
Score = 91.3 bits (223), Expect = 1e-17
Identities = 90/312 (28%), Positives = 144/312 (45%), Gaps = 24/312 (7%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
ML +FG++F PL LA+G D L G G ++ P+ G P +
Sbjct: 1 MLASTVFGVRFPGPLGLAAGF-DKDGMGLLAWGALGFGYAEVGTVTAYPQPGNPAPRMFR 59
Query: 65 LPY--GLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIF-------GGTPEEFAFLAEKL 115
LP L+N MG N G A + + + P+ V+I T +++ A +
Sbjct: 60 LPADRALLNRMGFNNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDYRASARLV 119
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSD--IRE 173
G +A +N+S P+ G + Q E++ ++ V T PV+ K+ P++SD I +
Sbjct: 120 GPLASYLVVNVSSPNTPG--LRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDD 177
Query: 174 LGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSL 233
+ A + G+ A NT ++ D I + GG SGP P+A RAV L
Sbjct: 178 ITDLAVELRLAGIVATNTT--VSRDCLVTPGIDALGAGGISGP---PVARRAVEVLRRLY 232
Query: 234 D-----IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEE 288
+ +I +GGI T DA + + AGAS LQ T G + I +GI+R L +
Sbjct: 233 GRVGDRLVLISVGGIETADDAWDRITAGASLLQGYTGFIYGGGFWPKHIHDGIARRLHDG 292
Query: 289 GYSSVKEIIGLA 300
G++S+++ +G A
Sbjct: 293 GFASLRDAVGSA 304
>sp|O25655|PYRD_HELPY DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431641|pir||C64646 dihydroorotate
dehydrogenase - Helicobacter pylori (strain 26695)
>gi|2314154|gb|AAD08055.1| (AE000609) dihydroorotate
dehydrogenase (pyrD) [Helicobacter pylori 26695]
Length = 351
Score = 91.3 bits (223), Expect = 1e-17
Identities = 84/311 (27%), Positives = 149/311 (47%), Gaps = 23/311 (7%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
LE + G+ F NPL LA+G D +LR G G + ++ E + G E P +
Sbjct: 50 LENEILGLHFPNPLGLAAGF-DKNASMLRALMAFGFGYLEAGTLTNEAQVGNERPRLFRH 108
Query: 66 --PYGLINAMGLPNPGWEAFLEEFRK-EKFDFPVIVSIFGGTP-------EEFAFLAEKL 115
L NAMG N G + F++ + P+ +++ E++ + K
Sbjct: 109 IEEESLQNAMGFNNYGAILGVRSFKRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLSKC 168
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVS--DIRE 173
+ D + NLS P+ + Q V+E+ K++T KP+ K+ P++ D+ E
Sbjct: 169 LNIGDYYTFNLSSPNTPN--LRDLQNKAFVHELFCMAKEMTHKPLFLKIAPDLETDDMLE 226
Query: 174 LGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSL 233
+ +A AGA G+ A NT ++ ++A + + GG SG + + +LA +
Sbjct: 227 IVNSAIGAGAHGIIATNTTIDKSL-VFAPK-----EMGGLSGKCLTKKSREIFKELAKAF 280
Query: 234 --DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYS 291
++ +GGI+ ++A E + GAS LQI +A G ++ + I + + + L+++G+
Sbjct: 281 FNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYNGPNLCQNILKDLVKLLQKDGFL 340
Query: 292 SVKEIIGLALK 302
SVKE IG L+
Sbjct: 341 SVKEAIGADLR 351
>pir||D81352 dihydroorotate oxidase (EC 1.3.3.1) Cj0804 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968250|emb|CAB73069.1| (AL139076) dihydroorotate
dehydrogenase [Campylobacter jejuni]
Length = 352
Score = 91.3 bits (223), Expect = 1e-17
Identities = 88/314 (28%), Positives = 146/314 (46%), Gaps = 29/314 (9%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L NL G+ F NP+ LA G D ++R G G + + +P++G E P + L
Sbjct: 51 LRQNLLGLDFNNPVGLAGGF-DKNATMIRPLSALGFGFLEVGTFTPKPQEGNEKPRLFRL 109
Query: 66 --PYGLINAMGLPNPGWEAFLEEFRKE-KFDFPVIVSIFGG--TP-----EEFAFLAEKL 115
+ NAMG N G E K F P+ V+I TP E++ L
Sbjct: 110 VKQESIQNAMGFNNEGAEKIALRLAKTYPFVLPLGVNIGKNKITPNDKALEDYFTLFRDF 169
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPN--VSDIRE 173
++ D F +N+S P+ K + Q + + +++ K +T KP++ K+ P+ + D
Sbjct: 170 KDLCDYFIVNISSPNTKN--LRELQNDDFLNTLLEEAKKITSKPILIKIAPDMKIDDALN 227
Query: 174 LGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNK--FGGYSGPGVKP---IALRAVYD 228
L A K GADG NT ++D +L N FGG SG + I + V
Sbjct: 228 LCENAIKKGADGFILANT----SVDY----SLLDNNRTFGGISGRLITEKSGIFFKEVTK 279
Query: 229 LASSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEE 288
+ + +I GGI + A E + GA+ +Q+ TA+ +G S+ + I + + L+++
Sbjct: 280 ILFGKTL-LIASGGIDSADIAYERIKNGANLVQVYTALIFKGPSLVKNINQNLIELLRKD 338
Query: 289 GYSSVKEIIGLALK 302
G+ + E +G+ LK
Sbjct: 339 GFLHISEAVGVNLK 352
>sp|P32748|PYRD_DROME DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIHYDROOROTATE OXIDASE)
(DHODEHASE) >gi|157228|gb|AAB59185.1| (L00964)
dihydroorotate dehydrogenase [Drosophila melanogaster]
Length = 389
Score = 90.1 bits (220), Expect = 3e-17
Identities = 84/298 (28%), Positives = 144/298 (48%), Gaps = 28/298 (9%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L + FG NP+ +A+G D E + G G + ++ ++G P + L
Sbjct: 86 LHTSFFGRMLSNPIGIAAGF-DKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRL 144
Query: 66 PY--GLINAMGLPNPGWEAFLEEFR----KEKFDFPVIVSIFGGTPEEFAFLAEKL---- 115
+IN G + G +A L+ R KE F+ V V++ G + +A+ +
Sbjct: 145 TEDKAIINRYGFNSDGHQAVLQRLRLLRKKENFNGVVGVNL-GRNKTTMSPIADYVQGVR 203
Query: 116 --GEVADAFELNLSCPHAKGY-GMEIGQKPENVYEVVKAVKDVTDK----PVIAKLTPNV 168
G VAD +N+S P+ KG M+ +K + E V K DK P++ KL+P++
Sbjct: 204 VFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLKLSPDL 263
Query: 169 S--DIRELG--LAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALR 224
S D++++ + +K+ DG+ NT ++ + K L+ + GG SGP +K +
Sbjct: 264 SLDDMKDIVWVIKRKKSRVDGLIVSNTT--VSRENIEKNK-LAEETGGLSGPPLKARSTE 320
Query: 225 AVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEG 280
+ + D IP+IG+GG+ + DA E + AGAS +QI TA+ G ++ +I G
Sbjct: 321 MIAQMYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAG 378
>sp|P46727|PYRD_MYCLE DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD)
Length = 356
Score = 89.7 bits (219), Expect = 4e-17
Identities = 89/312 (28%), Positives = 144/312 (45%), Gaps = 24/312 (7%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
+L +FG++F PL LA+G D L G G ++ P+ G P +
Sbjct: 48 VLASTVFGVRFPGPLGLAAGF-DKDGMGLLAWGALGFGYAEVGTVTAYPQPGNPAPRMFR 106
Query: 65 LPY--GLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIF-------GGTPEEFAFLAEKL 115
LP L+N MG N G A + + + P+ V+I T +++ A +
Sbjct: 107 LPADRALLNRMGFNNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDYRASARLV 166
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSD--IRE 173
G +A +N+S P+ G + Q E++ ++ V T PV+ K+ P++SD I +
Sbjct: 167 GPLASYLVVNVSSPNTPG--LRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDD 224
Query: 174 LGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSL 233
+ A + G+ A NT ++ D I + GG SGP P+A RAV L
Sbjct: 225 ITDLAVELRLAGIVATNTT--VSRDCLVTPGIDALGAGGISGP---PVARRAVEVLRRLY 279
Query: 234 D-----IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEE 288
+ +I +GGI T DA + + AGAS LQ T G + I +GI+R L +
Sbjct: 280 GRVGDRLVLISVGGIETADDAWDRITAGASLLQGYTGFIYGGGFWPKHIHDGIARRLHDG 339
Query: 289 GYSSVKEIIGLA 300
G++S+++ +G A
Sbjct: 340 GFASLRDAVGSA 351
>pir||D82193 dihydroorotate dehydrogenase VC1491 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9655993|gb|AAF94646.1|
(AE004227) dihydroorotate dehydrogenase [Vibrio
cholerae]
Length = 336
Score = 89.7 bits (219), Expect = 4e-17
Identities = 79/294 (26%), Positives = 141/294 (47%), Gaps = 24/294 (8%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELPY 67
V G+ FKNP+ LA+G+ D E + G G V ++ P+ G + P + L +
Sbjct: 47 VQCMGLTFKNPVGLAAGL-DKNGECIEAFGAMGFGFVEVGTVTPRPQAGNDKPRLFRLVH 105
Query: 68 --GLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGG--TP-----EEFAFLAEKLGEV 118
G+IN MG N G + +E ++ K+D + ++I TP E++ +K+
Sbjct: 106 AEGIINRMGFNNLGVDHLVENVKRAKYDGIIGINIGKNKDTPIEKGAEDYLICMDKVYPY 165
Query: 119 ADAFELNLSCPHAKGY-GMEIGQKPENVYEVVK------AVKDVTDKPVIAKLTPNVSD- 170
A +N+S P+ G ++ G+ + + +K A K P+ K+ P++SD
Sbjct: 166 AGYIAVNISSPNTPGLRSLQYGEALDELLAALKTRQAELAAKHDKYVPLALKIAPDLSDD 225
Query: 171 -IRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDL 229
I+++ + K D V A NT ++ K +N+ GG SG ++ + + L
Sbjct: 226 EIQQICQSLLKNKIDSVIATNTTLDRSLVEGMK---FANEAGGLSGRPLQNRSTEVIKCL 282
Query: 230 ASSL--DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGI 281
L +IP+IG+GGI ++ A E LLAGA +Q+ + +G + +I + +
Sbjct: 283 YKELGEEIPIIGVGGIDSYISAKEKLLAGAKLVQVYSGFIYQGPGLVADIVKNL 336
>sp|Q9RX14|PYRD_DEIRA DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7471808|pir||B75511 dihydroorotate
dehydrogenase - Deinococcus radiodurans (strain R1)
>gi|6458191|gb|AAF10081.1|AE001909_3 (AE001909)
dihydroorotate dehydrogenase [Deinococcus radiodurans]
Length = 369
Score = 89.3 bits (218), Expect = 5e-17
Identities = 86/307 (28%), Positives = 144/307 (46%), Gaps = 30/307 (9%)
Query: 15 FKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELPY--GLINA 72
F++PL LA+G+ D + + G G V ++ + G E P + LP LIN
Sbjct: 68 FESPLGLAAGL-DKNAQAVPAFTAFGFGFVEVGTVTPLAQSGNERPRLFRLPEDEALINR 126
Query: 73 MGLPNPGWEAFLEEFRK-EKFDFPVIVSIFGG--TP-----EEFAFLAEKLGEVADAFEL 124
MG N G A PV V+I TP E++ LG++ADAF +
Sbjct: 127 MGFNNGGTAAMHARLAVLTDRAAPVWVNIGKNKVTPNEDAAEDYRKCVRALGDLADAFVV 186
Query: 125 NLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDK---------PVIAKLTPNV--SDIRE 173
N+S P+ G + Q +++ +V+AV D + PV+ KL P++ +D
Sbjct: 187 NVSSPNTPG--LRALQAADDLAALVRAVLDEVEAGRVRTLRRPPVLVKLAPDLHPADFEA 244
Query: 174 LGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDL--AS 231
A AGA G+ NT + + R + GG SG + + V D +
Sbjct: 245 SVGAVLDAGASGLIISNTTLSRGGLSHPNR----EQAGGLSGRPLTDRSTELVRDAYRLT 300
Query: 232 SLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYS 291
+P++G+GG+ + +DA LLAGA +++ +A+ RG + REI G+ + L+ +G
Sbjct: 301 RGQVPIVGVGGVFSAEDAYAKLLAGADLVEVYSALIYRGPGLVREINAGLVKLLERDGVR 360
Query: 292 SVKEIIG 298
++ +++G
Sbjct: 361 NIADVVG 367
>pir||T15209 hypothetical protein W02D3.2 - Caenorhabditis elegans
>gi|2088734|gb|AAB54175.1| (AF003141) Similar to
dihydroorotate dehydrogenase [Caenorhabditis elegans]
Length = 411
Score = 87.8 bits (214), Expect = 1e-16
Identities = 88/329 (26%), Positives = 144/329 (43%), Gaps = 51/329 (15%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L+ LFG +FKNP+ LA+G + + A G G + S+ P+ G P + L
Sbjct: 90 LKCELFGREFKNPIGLAAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNNRPRVFRL 149
Query: 66 --PYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEKLGEV----- 118
G+IN G + G + R + + PE +A+ LG+
Sbjct: 150 LEDEGVINRYGFNSDGVGRVHQRVRSARDSW---------VPESYAYFGVNLGKNKLTED 200
Query: 119 ---------------ADAFELNLSCPHAKGYGMEIGQKPEN-------VYEVVKAVKDVT 156
D LN+S P+ G + QK + V++ ++ K
Sbjct: 201 AKLDYEIGVNYFAPHCDYLVLNVSSPNTPG--LRSMQKKSDLEKLLAYVHQALEMHKLEK 258
Query: 157 DKPVIAKLTPNV--SDIRELG--LAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGG 212
V K+ P++ S+++++ + +K DG+ NT IA Y R + GG
Sbjct: 259 QPQVFLKIAPDLIESELKDIAQVVTNKKFAIDGIIVSNTT--IARPDYL-RSENKTETGG 315
Query: 213 YSGPGVKPIA---LRAVYDLASSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLR 269
SG V+ I+ +R +Y L + IP+IG GG+ + DA E + AGAS +Q+ +A
Sbjct: 316 LSGAPVREISTECVRKIYKLTNG-QIPIIGCGGVFSGADAYEKIRAGASLVQLYSAFVYE 374
Query: 270 GFSVFREIAEGISRYLKEEGYSSVKEIIG 298
GF V +I + L+++G+S V E IG
Sbjct: 375 GFPVIGKIKRELVELLRKDGFSHVSEAIG 403
>gb|AAG03363.1| (AF024666) PyrD [Corynebacterium striatum]
Length = 359
Score = 86.6 bits (211), Expect = 3e-16
Identities = 82/312 (26%), Positives = 140/312 (44%), Gaps = 20/312 (6%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
+L +FG+ F PL LA+G D E + G G ++ + + G P +
Sbjct: 50 VLRQTVFGVDFPAPLGLAAGF-DKNAEAIDSWGAIGFGYAEMGTVTPKSQPGNPTPRLFR 108
Query: 65 LPY--GLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGGTPEEFAFLAEK-----LGE 117
LP ++N MG N G + R + V ++I E A + LG+
Sbjct: 109 LPEDKAILNRMGFNNKGALVVADNLRARRSRDVVGINIGKNKTSEDAVADYRATSTLLGQ 168
Query: 118 VADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPNVSD-----IR 172
+AD +N+S P+ G + Q E + +++ VK T PV+ K+ P++SD +
Sbjct: 169 LADYLVVNVSSPNTPG--LRDLQAVEELRPILEVVKKSTTTPVLVKIAPDLSDEDIDAVA 226
Query: 173 ELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASS 232
+L + E AG V+ T+ + A + + GG SG ++ +L + L
Sbjct: 227 DLAVELELAGI--VATNTTISRSGLKTPASK-VEKMGAGGISGAPLENRSLEVLKRLHER 283
Query: 233 LD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGY 290
+ + ++ +GGI+T + A E + AGAS LQ T G R I GI+ +K G
Sbjct: 284 VGDKLVLVSVGGISTPEQAWERITAGASLLQGYTPFIYGGLGWIRGIHRGIAAQIKAHGL 343
Query: 291 SSVKEIIGLALK 302
S+++ +G L+
Sbjct: 344 DSIEQAVGSGLE 355
>sp|Q9ZM11|PYRD_HELPJ DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431642|pir||E71935 dihydroorotate
dehydrogenase - Helicobacter pylori (strain J99)
>gi|4154946|gb|AAD05992.1| (AE001475) DIHYDROOROTATE
DEHYDROGENASE [Helicobacter pylori J99]
Length = 351
Score = 85.0 bits (207), Expect = 1e-15
Identities = 81/311 (26%), Positives = 148/311 (47%), Gaps = 23/311 (7%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
LE + G+ F NPL LA+G D +LR G G + ++ + G E P +
Sbjct: 50 LENEILGLNFPNPLGLAAGF-DKNASMLRALIAFGFGYLEAGTLTNIAQSGNEKPRLFRH 108
Query: 66 --PYGLINAMGLPNPGWEAFLEEFRK-EKFDFPVIVSIFGGTP-------EEFAFLAEKL 115
L NAMG N G + F + + P+ +++ E++ + +
Sbjct: 109 IEEESLQNAMGFNNYGAILGVRAFNRFAPYKTPIGINLGKNKHIEQAHALEDYQAVLNQC 168
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKLTPN--VSDIRE 173
+ D + NLS P+ + Q V E+ K++T KP+ K+ P+ + + E
Sbjct: 169 LNIGDYYTFNLSSPNTPN--LRDLQNKVFVNELFCMAKEMTHKPLFLKIAPDLEIDSMLE 226
Query: 174 LGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSL 233
+ +A +AGA+G+ A NT ++ ++A + + GG SG + + +LA +
Sbjct: 227 VVNSAIEAGANGIIATNTTIDKSL-VFAPK-----EMGGLSGKCLTKKSREIFKELAKAF 280
Query: 234 --DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYS 291
++ +GGI+ ++A E + GAS LQI +A +G ++ + I + + + L+++G+
Sbjct: 281 FNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYKGPNLCQNILKDLVKLLQKDGFL 340
Query: 292 SVKEIIGLALK 302
SVKE IG L+
Sbjct: 341 SVKEAIGADLR 351
>sp|P05021|PYRD_ECOLI DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|66054|pir||DEECDO dihydroorotate
oxidase (EC 1.3.3.1) - Escherichia coli
>gi|42609|emb|CAA26594.1| (X02826) dehydroorotate
dehydrogenae (aa 1-336) [Escherichia coli]
>gi|1651460|dbj|BAA35700.1| (D90732) Dihydroorotate
oxidase (EC 1.3.3.1) [Escherichia coli]
>gi|1787177|gb|AAC74031.1| (AE000196) dihydro-orotate
dehydrogenase [Escherichia coli K12]
Length = 336
Score = 84.7 bits (206), Expect = 1e-15
Identities = 80/296 (27%), Positives = 140/296 (47%), Gaps = 28/296 (9%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL-- 65
VN G+ FKNPL LA+G+ D E + G G + ++ P+ G + P + L
Sbjct: 47 VNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105
Query: 66 PYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGG--TP-----EEFAFLAEKLGEV 118
GLIN MG N G + +E +K +D + ++I TP +++ EK+
Sbjct: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165
Query: 119 ADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDK---------PVIAKLTPNVS 169
A +N+S P+ G + Q E + +++ A+K+ + P+ K+ P++S
Sbjct: 166 AGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223
Query: 170 DIRELGLAAE--KAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVY 227
+ + +A + DGV A NT ++ K ++ GG SG ++ + +
Sbjct: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIR 280
Query: 228 DLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGI 281
L+ L+ +P+IG+GGI + A E + AGAS +QI + +G + +EI I
Sbjct: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336
>pir||G81222 dihydroorotate dehydrogenase NMB0221 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7225444|gb|AAF40677.1| (AE002380) dihydroorotate
dehydrogenase [Neisseria meningitidis MC58]
Length = 335
Score = 84.3 bits (205), Expect = 2e-15
Identities = 74/296 (25%), Positives = 136/296 (45%), Gaps = 24/296 (8%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELP- 66
V L G+ NP+ LA+G+ D E + G G + ++ P+ G P + +P
Sbjct: 44 VKLMGMDLPNPVGLAAGL-DKNGEYIDALGALGFGFIEIGTVTPNPQPGNPQPRLFRVPE 102
Query: 67 -YGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSI-------FGGTPEEFAFLAEKLGEV 118
G+IN MG N G + + K KF + ++I +++ EK
Sbjct: 103 HQGIINRMGFNNHGIDTMIRNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAYAH 162
Query: 119 ADAFELNLSCPHAKGY-GMEIGQKPENVYEVVK----AVKDVTDK--PVIAKLTPNVSD- 170
A +N+S P+ K ++ G + + E +K + V K P+ K+ P++ +
Sbjct: 163 ASYITVNISSPNTKNLRALQGGDELSALLEALKNKQAQLASVHGKYVPLAVKIAPDLDEA 222
Query: 171 -IRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDL 229
I ++ + DG+ A NT I P L+ + GG SG V + R + L
Sbjct: 223 QIEDIAHVVKSVEMDGIIATNTT--IDKSSLGSHP-LAGEQGGLSGLPVHEKSNRVLKLL 279
Query: 230 ASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISR 283
A +D +P+IG+GGI +D+ + + GA+A+Q+ + + +G ++ +E + ++R
Sbjct: 280 ADHIDGKLPIIGVGGIMEGEDSADKIRLGATAVQVYSGLIYKGPALVKECLKALAR 335
>pir||D81995 dihydroorotate oxidase (EC 1.3.3.1) NMA0042 [imported] - Neisseria
meningitidis (group A strain Z2491)
>gi|7378818|emb|CAB83360.1| (AL162752) dihydroorotate
dehydrogenase [Neisseria meningitidis Z2491]
Length = 335
Score = 84.3 bits (205), Expect = 2e-15
Identities = 75/296 (25%), Positives = 136/296 (45%), Gaps = 24/296 (8%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELP- 66
V L G+ NP+ LA+G+ D E + G G + ++ +P+ G P + +P
Sbjct: 44 VKLMGMDLPNPVGLAAGL-DKNGEYIDALGALGFGFIEIGTVTPKPQPGNPQPRLFRVPE 102
Query: 67 -YGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSI-------FGGTPEEFAFLAEKLGEV 118
G+IN MG N G + + K KF + ++I +++ EK
Sbjct: 103 HQGIINRMGFNNHGIDTMIRNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAYAH 162
Query: 119 ADAFELNLSCPHAKGY-GMEIGQKPENVYEVVK----AVKDVTDK--PVIAKLTPNVSD- 170
A +N+S P+ K ++ G + + E +K + V K P+ K+ P++ +
Sbjct: 163 ASYITVNISSPNTKNLRALQGGDELSALLEALKNKQAQLASVYGKYVPLAVKIAPDLDEA 222
Query: 171 -IRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDL 229
I ++ + DG+ A NT I P L+ + GG SG V + R + L
Sbjct: 223 QIEDIAHVVKSVEMDGIIATNTT--IDKSSLGSHP-LAGEQGGLSGLPVHEKSNRVLKLL 279
Query: 230 ASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISR 283
A +D +P+IG+GGI DA + + GA+A+Q+ + + +G ++ +E + ++R
Sbjct: 280 ADHIDGKLPIIGVGGIMEGGDAADKIRLGATAVQVYSGLIYKGPALVKECLKALAR 335
>emb|CAB93362.1| (AL357523) dihydroorotate dehydrogenase [Streptomyces coelicolor
A3(2)]
Length = 368
Score = 82.7 bits (201), Expect = 5e-15
Identities = 83/315 (26%), Positives = 140/315 (44%), Gaps = 25/315 (7%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L G++ P LA+G D + G V ++ EP+ G + L
Sbjct: 50 LRTEALGLRMHGPFGLAAGF-DKNAVAIDGMAMLGFDHVEIGTVTGEPQPGNPKKRLFRL 108
Query: 66 --PYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGG----TPEEFAF-----LAEK 114
LIN MG N G A F +V + G PEE A AE+
Sbjct: 109 VADRALINRMGFNNDGSLAVAARLASRTPVFRTVVGVNIGKTKVVPEEEAVGDYVKSAER 168
Query: 115 LGEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDK-------PVIAKLTPN 167
L AD +N+S P+ G + Q E + ++ AV++ D+ P++ K+ P+
Sbjct: 169 LAPHADYLVVNVSSPNTPG--LRNLQATEALRPLLSAVREAADRAVTARRVPLLVKIAPD 226
Query: 168 VSD--IRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRA 225
++D + + A + G DG+ A NT A P L + GG SG +K +L
Sbjct: 227 LADEDVDAVADLAVELGLDGIIATNTTIAREGLGLTSSPALVGETGGLSGAPLKARSLEV 286
Query: 226 VYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISR 283
+ L + + I ++G+GG+ T +DA E +LAGA+ +Q +A G R + +G++
Sbjct: 287 LRRLYARVGDRITLVGVGGVETAEDAWERILAGATLVQGYSAFIYEGPFWGRAMHKGLAA 346
Query: 284 YLKEEGYSSVKEIIG 298
L++ Y+++ + +G
Sbjct: 347 RLRQSPYATLADAVG 361
>pir||A83263 dihydroorotate dehydrogenase PA3050 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9949156|gb|AAG06438.1|AE004730_2 (AE004730)
dihydroorotate dehydrogenase [Pseudomonas aeruginosa]
Length = 342
Score = 81.5 bits (198), Expect = 1e-14
Identities = 80/302 (26%), Positives = 138/302 (45%), Gaps = 34/302 (11%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L V++ G++F NP+ LA+G+ D + + + G G + ++ P+ G P + L
Sbjct: 44 LPVSVLGLEFPNPVGLAAGL-DKNGDAIDGFGQLGFGFIEIGTVTPRPQPGNPRPRLFRL 102
Query: 66 PYG--LINAMGLPNPGWEAFLEEFRKEK------------FDFPVIVSIFGGTPEEFAFL 111
P +IN MG N G + L R K FD PV ++ +++
Sbjct: 103 PQANAIINRMGFNNHGVDHLLARVRAAKYRGVLGINIGKNFDTPVERAV-----DDYLIC 157
Query: 112 AEKLGEVADAFELNLSCPHAKGY-GMEIGQKPENVYEVVK------AVKDVTDKPVIAKL 164
+K+ A +N+S P+ G ++ G + + E ++ A++ P+ K+
Sbjct: 158 LDKVYADASYVTVNVSSPNTPGLRSLQFGDSLKQLLEALRQRQEALALRHGRRVPLAIKI 217
Query: 165 TPNVSDIRELGLAAE--KAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIA 222
P+++D +AA +AG D V A NT + + P ++ GG SG V+ +
Sbjct: 218 APDMTDEETALVAAALVEAGMDAVIATNTT--LGREGVEGLPH-GDEAGGLSGAPVREKS 274
Query: 223 LRAVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEG 280
V LA L +P+I GGIT A E + AGAS +QI + +G ++ RE +
Sbjct: 275 THTVKVLAGELGGRLPIIAAGGITEGAHAAEKIAAGASLVQIYSGFIYKGPALIREAVDA 334
Query: 281 IS 282
I+
Sbjct: 335 IA 336
>sp|P32747|PYRD_SCHPO DIHYDROOROTATE DEHYDROGENASE PRECURSOR (DIHYDROOROTATE OXIDASE)
(DHODEHASE) >gi|418618|pir||A46248 dihydroorotate
oxidase (EC 1.3.3.1) - fission yeast
(Schizosaccharomyces pombe) >gi|5132|emb|CAA46230.1|
(X65114) dihydroorotate oxidase [Schizosaccharomyces
pombe] >gi|2058379|emb|CAB08175.1| (Z94864)
dihydroorotate dehydrogenase precursor
[Schizosaccharomyces pombe]
Length = 443
Score = 81.5 bits (198), Expect = 1e-14
Identities = 86/332 (25%), Positives = 139/332 (40%), Gaps = 56/332 (16%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L V ++G KF NP+ LA+G D + + G + S+ +P+ G P L
Sbjct: 105 LAVEVWGKKFCNPIGLAAGF-DKQADAISGLLNFGFSYLEIGSVTPKPQPGNPKPRYFRL 163
Query: 66 PYGL--INAMGLPNPGWEAFLEEFRKEKFDF-----PVIVSIFGGTP------------- 105
L IN G + G +A L + +K + P ++ F P
Sbjct: 164 KPDLSVINRYGFNSIGHDAILAKIQKRVRKYIAKTSPQLLKQFDANPASCTDPAVLGVPR 223
Query: 106 ---------------------EEFAFLAEKLGEVADAFELNLSCPHAKGYGMEIGQKPEN 144
E++ G AD +N+S P+ G + QK
Sbjct: 224 SLIPNKFLGINLGKNKNGNEIEDYVEGVRTFGNFADILVINVSSPNTPG--LRNLQKKSA 281
Query: 145 VYEVVKAVKDVTDK------PVIAKLTP--NVSDIRELGLAAEKAGADGVSAINTVKAIA 196
+ ++ AV +K PV+ K+ P N ++ ++ +K DGV NT
Sbjct: 282 LSTLLTAVVSERNKLNSPHPPVLVKIAPDLNEEELTDIADVLKKCKIDGVIVGNTTVQRP 341
Query: 197 IDIYAKRPILSNKFGGYSGPGVKPIALRAVYDLASSL--DIPVIGIGGITTWQDAVEFLL 254
+ + + + GG SGP +KPIAL + L L DIP+IG GGI++ +DA+E+
Sbjct: 342 KTLKSTSHV--EETGGLSGPPLKPIALNTLRTLRKHLSSDIPIIGCGGISSGKDAIEYAR 399
Query: 255 AGASALQIGTAVYLRGFSVFREIAEGISRYLK 286
AGA+ +Q+ TA+ G + +I + I LK
Sbjct: 400 AGATMVQVYTALGYDGPVIAHKIKQEILAELK 431
>sp|P74782|PYRD_SYNY3 DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|7431640|pir||S76039 probable
dihydroorotate oxidase (EC 1.3.3.1) - Synechocystis sp.
(strain PCC 6803)
Length = 381
Score = 79.6 bits (193), Expect = 4e-14
Identities = 85/320 (26%), Positives = 147/320 (45%), Gaps = 32/320 (10%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L+ +G+ F N L L++G D E G G ++ + G + P + L
Sbjct: 60 LQQTCWGLNFPNVLGLSAGC-DKEGEAAAVWPALGFGFAELGAVTKYAQPGNDRPRLFRL 118
Query: 66 PY--GLINAMGLPNPGWEAFLEEFRKEKFDF-----PVIVSIFGG--TP-----EEFAFL 111
P ++N +G N G A + K +D+ P+ +++ TP E++ F
Sbjct: 119 PQDQAVLNRLGANNEGAVAMAAKL-KHTWDYYPRTIPIGINLCKSKITPLDQAVEDYVFS 177
Query: 112 AEKLGEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVT--DKPVIAKLTPNVS 169
+ L VAD F +N+S P+ G + Q+ + + + ++ KP++ K++P++S
Sbjct: 178 FQTLAPVADYFVVNVSSPNTPG--LRSLQESDELPRIFAGLQSANHWQKPLLVKISPDLS 235
Query: 170 --DIRELGLAAEKAGADGVSAINTV---KAIAIDIYAK--RPILSNKFGGYSGPGVKPIA 222
I + ++ G+ A NT + I + +PI + GG SG ++ A
Sbjct: 236 WEAIAVIIDLVKEHNLSGIVATNTSTRRSGLKTKILPQTGQPI-EQEAGGLSGQPIRDRA 294
Query: 223 ---LRAVYDLASSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAE 279
+R +Y IP+IG+GGI T +DA E + AGAS LQI T G V +I +
Sbjct: 295 TEVIRYIYQQTGGT-IPIIGVGGIFTAEDAWEKIQAGASFLQIYTGWIYGGPWVVSDILQ 353
Query: 280 GISRYLKEEGYSSVKEIIGL 299
G+ L G+S + E +G+
Sbjct: 354 GLGEKLAAGGFSHISEAVGI 373
>sp|P25468|PYRD_SALTY DIHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASE)
(DHODASE) (DHOD) >gi|47870|emb|CAA39161.1| (X55636)
dihydroorotate oxidase [Salmonella typhimurium]
Length = 336
Score = 78.0 bits (189), Expect = 1e-13
Identities = 77/294 (26%), Positives = 134/294 (45%), Gaps = 24/294 (8%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL-- 65
V G+ FKNPL LA+G+ D E + G G + ++ P+ G + P + L
Sbjct: 47 VTCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSLEIGTVTPRPQPGNDKPRLFRLVD 105
Query: 66 PYGLINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGG--TP-----EEFAFLAEKLGEV 118
GLIN MG N G + +E +K FD + ++I TP +++ EK+
Sbjct: 106 AEGLINRMGFNNLGVDNLVENVKKAHFDGILGINIGKNKDTPVENGKDDYLICMEKVYAY 165
Query: 119 ADAFELNLSCPHAKGYG-MEIGQKPENVYEVVKAVKDVTDK------PVIAKLTPNVSDI 171
A +N+S P+ G ++ G +++ +K ++ PV K+ P++ +
Sbjct: 166 AGYIAINISSPNTPGLRTLQYGDALDDLLTAIKNKQNDLQAIHHKYVPVAVKIAPDLCEE 225
Query: 172 RELGLAAE--KAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDL 229
+ +A + DGV A NT ++ K + GG SG ++ + + L
Sbjct: 226 ELIQVADSLLRHNIDGVIATNTTLDRSLVQGMKN---CQQTGGLSGRPLQLKSTEIIRRL 282
Query: 230 ASSL--DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGI 281
+ L +P+IG+GGI + A E + AGA+ +QI + +G + +EI I
Sbjct: 283 SQELKGQLPIIGVGGIDSVIAAREKIAAGATLVQIYSGFIFKGPPLIKEIVTHI 336
>dbj|BAA18627.1| (D90916) dihydroorotate dehydrogenase [Synechocystis sp.]
Length = 294
Score = 75.7 bits (183), Expect = 6e-13
Identities = 78/283 (27%), Positives = 133/283 (46%), Gaps = 35/283 (12%)
Query: 43 GVVTKSIGMEPRKGYENPTIVELPY--GLINAMGLPNPGWEAFLEEFRKEKFDF-----P 95
G VTK + G + P + LP ++N +G N G A + K +D+ P
Sbjct: 13 GAVTKYA----QPGNDRPRLFRLPQDQAVLNRLGANNEGAVAMAAKL-KHTWDYYPRTIP 67
Query: 96 VIVSIFGG--TP-----EEFAFLAEKLGEVADAFELNLSCPHAKGYGMEIGQKPENVYEV 148
+ +++ TP E++ F + L VAD F +N+S P+ G + Q+ + + +
Sbjct: 68 IGINLCKSKITPLDQAVEDYVFSFQTLAPVADYFVVNVSSPNTPG--LRSLQESDELPRI 125
Query: 149 VKAVKDVT--DKPVIAKLTPNVS--DIRELGLAAEKAGADGVSAINTV---KAIAIDIYA 201
++ KP++ K++P++S I + ++ G+ A NT + I
Sbjct: 126 FAGLQSANHWQKPLLVKISPDLSWEAIAVIIDLVKEHNLSGIVATNTSTRRSGLKTKILP 185
Query: 202 K--RPILSNKFGGYSGPGVKPIA---LRAVYDLASSLDIPVIGIGGITTWQDAVEFLLAG 256
+ +PI + GG SG ++ A +R +Y IP+IG+GGI T +DA E + AG
Sbjct: 186 QTGQPI-EQEAGGLSGQPIRDRATEVIRYIYQQTGGT-IPIIGVGGIFTAEDAWEKIQAG 243
Query: 257 ASALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGL 299
AS LQI T G V +I +G+ L G+S + E +G+
Sbjct: 244 ASFLQIYTGWIYGGPWVVSDILQGLGEKLAAGGFSHISEAVGI 286
>pir||S77079 hypothetical protein sll0744 - Synechocystis sp. (strain PCC 6803)
>gi|1006615|dbj|BAA10771.1| (D64005) hypothetical
protein [Synechocystis sp.]
Length = 343
Score = 73.7 bits (178), Expect = 2e-12
Identities = 81/314 (25%), Positives = 133/314 (41%), Gaps = 33/314 (10%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPEL--LRRAHREGAGGVVTKSIGMEPRKGYENPTIV 63
L G+ K+PL++ S +T EL L++ GA +V S E +
Sbjct: 3 LTTQYLGLNLKSPLVVGS-CAPLTEELGNLKKMEDSGAAAIVLHSFFEEQLRQERLEMYH 61
Query: 64 ELPYGLINAMG----LPNP-----GWEAFLEEFR--KEKFDFPVIVSIFGGTPEEFAFLA 112
L +G + P P G E +L R KE D P+I S+ G T + +
Sbjct: 62 HLTHGTHSFAEALTYFPEPQVFHVGSEEYLNHIRLAKESLDIPIIGSLNGSTLGGWLDYS 121
Query: 113 EKL-GEVADAFELN-------LSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDKPVIAKL 164
+++ G ADA ELN L P G E+ +N ++VKAVKD PV K+
Sbjct: 122 QQMEGAGADAIELNIYYVPTDLDVP-----GTEV---EKNYLDIVKAVKDEVKIPVAVKI 173
Query: 165 TPNVSDIRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALR 224
+P S++ + GADG+ N D+ + + + + P+
Sbjct: 174 SPFFSNMAYMAKKFADYGADGLVLFNRFYQPDFDLESLE-VYPHILLSTTQSMRLPLHWL 232
Query: 225 AVYDLASSLDIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGISRY 284
A+ L +D + GI D V+ L+AGA Q+ +A+ G + ++R+
Sbjct: 233 AI--LYGRIDCDLAATSGILHTVDLVKVLMAGAKITQLVSALLRHGIGYIHTLENSLARW 290
Query: 285 LKEEGYSSVKEIIG 298
++E Y SV+++ G
Sbjct: 291 MEEHEYESVQQMQG 304
>dbj|BAB11988.1| (AB038557) dihydroorotate dehydrogenase [Oryza sativa]
Length = 468
Score = 73.4 bits (177), Expect = 3e-12
Identities = 86/344 (25%), Positives = 148/344 (43%), Gaps = 52/344 (15%)
Query: 5 MLEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVE 64
+L + ++G KF NP+ LA+G D E + G G V S+ P++G P I
Sbjct: 131 VLGLEIWGRKFTNPIGLAAGF-DKNAEAVEGLLGMGFGFVEVGSVTPLPQEGNPKPRIFR 189
Query: 65 LPY--GLINAMGLPNPGWEAFLE----EFRKEKFD------FPVIVSIFGGTPEEFAFLA 112
L +IN G + G + + K K + P + G L
Sbjct: 190 LREHGAVINRCGFNSEGIVVVAKRLGAQHGKRKMEETSSSTSPTTSDVKQGGKAGPGILG 249
Query: 113 EKLG--------------------EVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAV 152
LG + AD +N+S P+ G G+K + ++VK V
Sbjct: 250 VNLGKNKISEDATADYVQGVHTLSQYADYLVINVSSPNTPGLRKLQGRK--QLKDLVKKV 307
Query: 153 KDVTDK---------PVIAKLTPNVS--DIRELGLAAEKAGADGVSAINTVKAIAIDIYA 201
+ D+ P++ K+ P++S D+ ++ A DG+ NT I+ A
Sbjct: 308 QAARDEMQWAEDGPPPLLVKIAPDLSKQDLEDIAAVALALRLDGLIISNTT--ISRPSPA 365
Query: 202 KRPILSNKFGGYSGPGVKPIA---LRAVYDLASSLDIPVIGIGGITTWQDAVEFLLAGAS 258
L+ + GG SG + ++ LR +Y L IP+IG GG+++ +DA + + +GA+
Sbjct: 366 DTHPLAQEAGGLSGKPLFDLSTNVLREMYILTRG-KIPLIGCGGVSSGEDAYKKIRSGAT 424
Query: 259 ALQIGTAVYLRGFSVFREIAEGISRYLKEEGYSSVKEIIGLALK 302
+Q+ TA G ++ I ++ L+ +G+ SV+E +G K
Sbjct: 425 LVQLYTAFAYGGPALIPRIKAELAECLERDGFKSVQEAVGADFK 468
>pir||F82541 dihydroorotate dehydrogenase XF2571 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9107785|gb|AAF85368.1|AE004064_10
(AE004064) dihydroorotate dehydrogenase [Xylella
fastidiosa]
Length = 359
Score = 72.2 bits (174), Expect = 7e-12
Identities = 74/301 (24%), Positives = 130/301 (42%), Gaps = 29/301 (9%)
Query: 6 LEVNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVEL 65
L FG+ F NP+ LA+G+ D + G G + + P+ G P + L
Sbjct: 52 LPTTAFGLNFPNPVGLAAGL-DKNGTHIDALFALGFGFIEIGTTTPRPQPGNPKPRLFRL 110
Query: 66 PY--GLINAMGLPNPGWEAFLEEF---RKEKFDFPVIVSIFGGTPEE-----FAFLAEKL 115
+IN MG N G +A + R+ + + TP E + + E++
Sbjct: 111 TQQQAVINRMGFNNLGVDALVRNVAGARQRNGPLGINIGKNKDTPNEQASNDYRYCLERV 170
Query: 116 GEVADAFELNLSCPHAKGYGMEIGQKPENVYEVVKAVKDVTDK---------PVIAKLTP 166
+AD +NLS P+ G + Q+ + + ++ +++ + P++ K+ P
Sbjct: 171 YALADYVTINLSSPNTAG--LRALQEEQTLRRLIGELREAQETLAAKHGRHVPMLIKMAP 228
Query: 167 NVSD--IRELGLAAEKAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALR 224
++SD I + DGV A NT + ++ L+++ GG SG + +
Sbjct: 229 DLSDSDIDAAARVLNEMSVDGVIATNTTVTRPL---LRQHRLASETGGLSGAPLLGQSTL 285
Query: 225 AVYDLASSLD--IPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGIS 282
+ L + L I +IG+GGI DAV + AGA+ +Q T + +G + E E I
Sbjct: 286 VLRRLRTHLPETIALIGVGGICCGADAVAKMAAGANLVQCYTGLIFKGPQLVGECVEAIR 345
Query: 283 R 283
R
Sbjct: 346 R 346
>pir||S13824 dihydroorotate oxidase (EC 1.3.3.1) - Salmonella typhimurium
Length = 336
Score = 71.8 bits (173), Expect = 9e-12
Identities = 75/294 (25%), Positives = 132/294 (44%), Gaps = 24/294 (8%)
Query: 8 VNLFGIKFKNPLILASGVVDMTPELLRRAHREGAGGVVTKSIGMEPRKGYENPTIVELPY 67
V G+ FKNPL LA+G+ D + G G + ++ P+ G + P + L
Sbjct: 47 VTCMGLTFKNPLGLAAGL-DKDGLCIDALGAMGFGSLEIGTVTPRPQPGNDKPRLFRLVD 105
Query: 68 G--LINAMGLPNPGWEAFLEEFRKEKFDFPVIVSIFGG--TP-----EEFAFLAEKLGEV 118
LIN MG N G + +E +K FD + ++I TP +++ EK+
Sbjct: 106 AEKLINRMGFNNLGVDNLVENVKKAHFDGILGINIGKNKDTPVENGKDDYLICMEKVYAY 165
Query: 119 ADAFELNLSCPHAKGYG-MEIGQKPENVYEVVKAVKDVTDK------PVIAKLTPNVSDI 171
A +N+S P+ G ++ G +++ +K ++ PV K+ P++ +
Sbjct: 166 AGYIAINISSPNTPGLRTLQYGDALDDLLTAIKNKQNDLQAIHHKYVPVAVKIAPDLCEE 225
Query: 172 RELGLAAE--KAGADGVSAINTVKAIAIDIYAKRPILSNKFGGYSGPGVKPIALRAVYDL 229
+ +A + DGV A NT ++ K + GG SG ++ + + L
Sbjct: 226 ELIQVADSLLRHNIDGVIATNTTLDRSLVQGMKN---CQQTGGLSGRPLQLKSTEIIRRL 282
Query: 230 ASSL--DIPVIGIGGITTWQDAVEFLLAGASALQIGTAVYLRGFSVFREIAEGI 281
+ L +P+IG+GGI + A E + AGA+ +QI + +G + +EI I
Sbjct: 283 SQELKGQLPIIGVGGIDSVIAAREKIAAGATLVQIYSGFIFKGPPLIKEIVTHI 336
>gb|AAF36476.1|AF128264_1 (AF128264) dihydroorotate dehydrogenase [Streptococcus gordonii]
Length = 117
Score = 68.7 bits (165), Expect = 8e-11
Identities = 35/93 (37%), Positives = 53/93 (56%), Gaps = 2/93 (2%)
Query: 208 NKFGGYSGPGVKPIALRAVYDLASSL--DIPVIGIGGITTWQDAVEFLLAGASALQIGTA 265
N FGG G +KP AL V+ L +I +IG GG+ T +DA E +L GAS +Q+GT
Sbjct: 18 NGFGGIGGQYIKPTALANVHAFYQRLKPEIQIIGTGGVLTGRDAFEHILCGASMVQVGTT 77
Query: 266 VYLRGFSVFREIAEGISRYLKEEGYSSVKEIIG 298
++ G F I + ++E+GY S+++ G
Sbjct: 78 LHKEGVVAFERITAKLKTIMEEKGYESLEDFRG 110
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.140 0.401
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 113722847
Number of Sequences: 2977
Number of extensions: 4991342
Number of successful extensions: 12904
Number of sequences better than 1.0e-10: 70
Number of HSP's better than 0.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 12717
Number of HSP's gapped (non-prelim): 74
length of query: 303
length of database: 189,106,746
effective HSP length: 55
effective length of query: 248
effective length of database: 156,189,961
effective search space: 38735110328
effective search space used: 38735110328
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)