BLASTP 2.0.10 [Aug-26-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= PAB1943 (RTCA) DE:PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (EC 6.5.1.4) (RNA-3'- PHOSPHATE CYCLASE) (RNA CYCLASE). (342 letters) Database: ./suso.pep; /banques/blast2/nr.pep 598,487 sequences; 189,106,746 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value sp|Q9V0Z6|RTCA_PYRAB PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 686 0.0 pir||G71029 probable phosphate cyclase - Pyrococcus horikoshii >... 603 e-171 sp|O59198|RTCA_PYRHO PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 603 e-171 gi|11499030 conserved hypothetical protein [Archaeoglobus fulgid... 310 2e-83 sp|Q60335|RTCA_METJA PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 303 2e-81 gb|AAK42586.1| RNA 3' terminal phosphate cyclase (RNA 3' phospha... 287 9e-77 sp|O27937|RTCA_METTH PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 275 5e-73 sp|O66884|RTCA_AQUAE PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 256 4e-67 sp|Q9YES0|RTCA_AERPE PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 255 6e-67 pir||T13745 hypothetical protein 22E5.3 - fruit fly (Drosophila ... 208 1e-52 gi|4506589 RNA 3'-terminal phosphate cyclase [Homo sapiens] >gi|... 207 1e-52 sp|P46849|RTCA_ECOLI RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-P... 201 1e-50 pdb|1QMH|B Chain B, Crystal Structure Of Rna 3'-Terminal Phospha... 201 1e-50 pdb|1QMI|A Chain A, Crystal Structure Of Rna 3'-Terminal Phospha... 197 1e-49 pir||E83072 RNA 3'-terminal phosphate cyclase PA4585 [imported] ... 181 9e-45 sp|O15746|RTC1_DICDI PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 175 7e-43 gb|AAG19210.1| (AE005017) RNA 3'-terminal phosphate cyclase; Tpc... 173 2e-42 pir||G65137 hypothetical 15.4 kD protein in malT-glpR intergenic... 117 2e-25 emb|CAB89811.1| (AJ276894) RNA 3'-terminal phosphate cyclase-lik... 96 6e-19 gi|10946950 RNA cyclase homolog; RNA 3'-terminal phosphate cycla... 96 6e-19 gi|11429125 RNA cyclase homolog [Homo sapiens] 95 1e-18 dbj|BAB14300.1| (AK022904) unnamed protein product [Homo sapiens] 94 3e-18 sp|Q23400|RTC2_CAEEL PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 89 6e-17 sp|Q09870|RTC1_SCHPO PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE ... 87 3e-16 pir||F65137 hypothetical 21.7 kD protein in malT-glpR intergenic... 81 2e-14 gb|AAA83889.1| (M13585) ORFX; putative [Escherichia coli] 76 6e-13 >sp|Q9V0Z6|RTCA_PYRAB PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) >gi|7450875|pir||D75184 probable RNA-3'-phosphate cyclase (EC 6.5.1.4) PAB1943 - Pyrococcus abyssi (strain Orsay) >gi|5458065|emb|CAB49555.1| (AJ248284) PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (EC 6.5.1.4) (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE). [Pyrococcus abyssi] Length = 342 Score = 686 bits (1750), Expect = 0.0 Identities = 342/342 (100%), Positives = 342/342 (100%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN Sbjct: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG Sbjct: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT Sbjct: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA Sbjct: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEIW 300 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEIW Sbjct: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEIW 300 Query: 301 VSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVVRRVE 342 VSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVVRRVE Sbjct: 301 VSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVVRRVE 342 >pir||G71029 probable phosphate cyclase - Pyrococcus horikoshii >gi|3257956|dbj|BAA30639.1| (AP000006) 369aa long hypothetical phosphate cyclase [Pyrococcus horikoshii] Length = 369 Score = 603 bits (1537), Expect = e-171 Identities = 280/341 (82%), Positives = 325/341 (95%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MITIDGSYGEGGGQILRTS+ALS ITGEPVRI+NIRANRPNPGLRPQHLH ILALKHLAN Sbjct: 29 MITIDGSYGEGGGQILRTSVALSTITGEPVRIVNIRANRPNPGLRPQHLHAILALKHLAN 88 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 A+VKGAHVGSRELVFIPK+LEAK++ ++IGTAGSITLVLQALLPAM FA+ +V+F+ITGG Sbjct: 89 AEVKGAHVGSRELVFIPKKLEAKEISIDIGTAGSITLVLQALLPAMVFAREKVKFRITGG 148 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 TDV WSPPVDYL+NVTLFALEK+GI I+++RRGHYPKGGGI+EGYVEPW E+RELVA Sbjct: 149 TDVSWSPPVDYLSNVTLFALEKIGIHGEIRVIRRGHYPKGGGIVEGYVEPWNEKRELVAK 208 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 +YS I K+EGISHATNLP+HVAERQA+AAK+EL +L+VP++I+TE+S+S+GPGSGIVVWA Sbjct: 209 EYSRIIKIEGISHATNLPSHVAERQARAAKDELLQLKVPIEIRTEISRSIGPGSGIVVWA 268 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEIW 300 ETDCLRLGGDALGK+GKPAE+VGKEAAQELL+QLKPG+CVDKFLGDQLIPFLAFSGG IW Sbjct: 269 ETDCLRLGGDALGKKGKPAEIVGKEAAQELLDQLKPGHCVDKFLGDQLIPFLAFSGGVIW 328 Query: 301 VSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVVRRV 341 VSE+TNHLKTNIWVVE+FLG++FD+DG VG+PGK++V+RRV Sbjct: 329 VSEITNHLKTNIWVVESFLGRIFDVDGNVGEPGKIRVIRRV 369 >sp|O59198|RTCA_PYRHO PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) Length = 341 Score = 603 bits (1537), Expect = e-171 Identities = 280/341 (82%), Positives = 325/341 (95%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MITIDGSYGEGGGQILRTS+ALS ITGEPVRI+NIRANRPNPGLRPQHLH ILALKHLAN Sbjct: 1 MITIDGSYGEGGGQILRTSVALSTITGEPVRIVNIRANRPNPGLRPQHLHAILALKHLAN 60 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 A+VKGAHVGSRELVFIPK+LEAK++ ++IGTAGSITLVLQALLPAM FA+ +V+F+ITGG Sbjct: 61 AEVKGAHVGSRELVFIPKKLEAKEISIDIGTAGSITLVLQALLPAMVFAREKVKFRITGG 120 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 TDV WSPPVDYL+NVTLFALEK+GI I+++RRGHYPKGGGI+EGYVEPW E+RELVA Sbjct: 121 TDVSWSPPVDYLSNVTLFALEKIGIHGEIRVIRRGHYPKGGGIVEGYVEPWNEKRELVAK 180 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 +YS I K+EGISHATNLP+HVAERQA+AAK+EL +L+VP++I+TE+S+S+GPGSGIVVWA Sbjct: 181 EYSRIIKIEGISHATNLPSHVAERQARAAKDELLQLKVPIEIRTEISRSIGPGSGIVVWA 240 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEIW 300 ETDCLRLGGDALGK+GKPAE+VGKEAAQELL+QLKPG+CVDKFLGDQLIPFLAFSGG IW Sbjct: 241 ETDCLRLGGDALGKKGKPAEIVGKEAAQELLDQLKPGHCVDKFLGDQLIPFLAFSGGVIW 300 Query: 301 VSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVVRRV 341 VSE+TNHLKTNIWVVE+FLG++FD+DG VG+PGK++V+RRV Sbjct: 301 VSEITNHLKTNIWVVESFLGRIFDVDGNVGEPGKIRVIRRV 341 >gi|11499030 conserved hypothetical protein [Archaeoglobus fulgidus] >gi|3914932|sp|O28837|RTCA_ARCFU PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) >gi|7450873|pir||B69429 conserved hypothetical protein AF1435 - Archaeoglobus fulgidus >gi|2649133|gb|AAB89810.1| (AE001004) conserved hypothetical protein [Archaeoglobus fulgidus] Length = 328 Score = 310 bits (785), Expect = 2e-83 Identities = 165/329 (50%), Positives = 217/329 (65%), Gaps = 9/329 (2%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MI IDGS+GEGGGQILRT++ALS +TG+ VRI NIRANRP PGL QHL GI A K ++N Sbjct: 1 MIEIDGSFGEGGGQILRTAVALSCVTGKAVRIRNIRANRPKPGLAAQHLKGIEAAKIISN 60 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 A+V+G +GS E+VF P + V+IGTAGS+TL+ Q +L + FA +TGG Sbjct: 61 AEVEGLRIGSTEIVFNPGSVRGGNFRVDIGTAGSVTLIFQTVLLPLLFADRDSTLTVTGG 120 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 TDV W+PPVDY NVTL AL ++G +++++RG+YPKGGG++ V P E + +V Sbjct: 121 TDVAWAPPVDYFKNVTLRALREMGAECELEVLKRGYYPKGGGMVRLTVRP-AEMKGVVYE 179 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 + I V G+SH NLP HVAERQA +A+ L + + +I+TEV K L GSGIV+W+ Sbjct: 180 RIDEI--VRGVSHCQNLPGHVAERQASSARNFLEERGIRAEIRTEVLKGLSTGSGIVLWS 237 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGG--E 298 GG ALG+RGK AEVVG+EAA+ L +L D L DQ++PF A + G E Sbjct: 238 GYK----GGSALGERGKRAEVVGQEAAESLYRELMSDAAFDAHLADQVMPFAAMARGRTE 293 Query: 299 IWVSEVTNHLKTNIWVVENFLGKVFDLDG 327 SEVT H K+N +V+ FLGKV +G Sbjct: 294 YTTSEVTMHQKSNAYVINTFLGKVVKFEG 322 >sp|Q60335|RTCA_METJA PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) >gi|2128089|pir||A64303 conserved hypothetical protein MJ0025 - Methanococcus jannaschii >gi|1498784|gb|AAB98006.1| (U67461) hypothetical protein [Methanococcus jannaschii] Length = 338 Score = 303 bits (768), Expect = 2e-81 Identities = 157/325 (48%), Positives = 221/325 (67%), Gaps = 7/325 (2%) Query: 2 ITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANA 61 I IDGSY EGGGQI+RT+++LSA+T +PV+IINIR R N GL PQH+ + A+K L NA Sbjct: 4 IVIDGSYLEGGGQIIRTAVSLSALTQKPVKIINIRKKRKNKGLAPQHVSAVKAVKKLCNA 63 Query: 62 DVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGT 121 +V G +VGS EL FIP +L K ++IGTAGSI+LV+Q LLP + KI GGT Sbjct: 64 EVFGLNVGSEELTFIPSKLSPKDFTIDIGTAGSISLVIQTLLPLSLGINKKFTVKIKGGT 123 Query: 122 DVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERR-ELVAT 180 DV +PP+DY+ NVTL L G++ +K+++RG YP+GGG + V+P K ++ +L+ Sbjct: 124 DVKRAPPIDYVKNVTLKILRNFGVLTELKVLKRGFYPEGGGEVIFEVKPSKIKKFDLIEH 183 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 S++ VEGIS+ NL +A R K A + L+K ++ IK E SK + G+GIV+W Sbjct: 184 SKSNL--VEGISYVQNLDESIARRMRKKAVDLLNKEKLLPNIKIECSKGISTGAGIVLWN 241 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEIW 300 +T LGG LG++G AE+V + A ELL++ + G +DK++GDQ+IPFLAF G + Sbjct: 242 DT----LGGSCLGEKGLRAEIVAERAVNELLKERESGMALDKYMGDQIIPFLAFGKGIVG 297 Query: 301 VSEVTNHLKTNIWVVENFLGKVFDL 325 VSE+TNH KTN+WVV++FL F++ Sbjct: 298 VSEITNHTKTNMWVVKHFLDVDFEI 322 >gb|AAK42586.1| RNA 3' terminal phosphate cyclase (RNA 3' phosphate cyclase) (RNA cyclase) (rtcA) [Sulfolobus solfataricus] Length = 345 Score = 287 bits (728), Expect = 9e-77 Identities = 152/332 (45%), Positives = 223/332 (66%), Gaps = 9/332 (2%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MI IDGS+GEGGGQILRTS+ LS ITG+P RI NIRANRPNPGL+ QHL + A+K ++N Sbjct: 9 MIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVRAMKMISN 68 Query: 61 ADVKGAHVGSRELVFIPKRLEAKK-VEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITG 119 A+ KG VGS+EL FIP ++ ++++IGTAGS+TL++Q ++PA+ R+ KI G Sbjct: 69 AETKGDEVGSKELTFIPHEIKGNSIIDIDIGTAGSVTLIMQTMIPAIINKNMRI--KIKG 126 Query: 120 GTDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGG--IIEGYVEPWKERREL 177 GTDVP SP +DY+ V L L K+GI + + +++RGHYP+GGG IIE + Sbjct: 127 GTDVPKSPTIDYIRLVYLEILRKIGIESKVNLIKRGHYPEGGGEVIIENVN---GNPSDF 183 Query: 178 VATKYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSK-SLGPGSGI 236 + + ++GISH ++LP+H+AERQ +AK LSKL V ++I+T+V + + GSGI Sbjct: 184 SLLELGKLIMIKGISHVSSLPSHIAERQKDSAKAILSKLGVQIEIETDVRQGEVSKGSGI 243 Query: 237 VVWAETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG 296 + A + +G D+LG+RGK AE+VG+EAA++L++ L VD + D L+ F + G Sbjct: 244 ALAAIGEKSIIGADSLGERGKRAEIVGEEAARKLIDNLNTKAAVDVHMSDMLMIFTSLFG 303 Query: 297 GEIWVSEVTNHLKTNIWVVENFLGKVFDLDGE 328 GE +E+T+H TN+ ++ FL ++ G+ Sbjct: 304 GEYIGAELTSHAYTNMEIIRKFLDVKIEISGK 335 >sp|O27937|RTCA_METTH PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) >gi|7450872|pir||G69122 conserved hypothetical protein MTH1915 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2623049|gb|AAB86375.1| (AE000942) conserved protein [Methanobacterium thermoautotrophicum] Length = 337 Score = 275 bits (696), Expect = 5e-73 Identities = 151/340 (44%), Positives = 216/340 (63%), Gaps = 5/340 (1%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MI IDGS GEGGG ++R S AL+A+T VR+ NIRA R GL QHL + A+ ++N Sbjct: 1 MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISN 60 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 ++G +GS EL F P R+ ++ TAGS LVLQA++ A A ++ ++ ++GG Sbjct: 61 GTLRGDELGSMELEFSPGRVTGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGG 120 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 TDV W+P DYL VT+ LE +G A I+I+RRG+YP+GGG + +EP + R + Sbjct: 121 TDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEGGGRVHAIIEPSELRP--ITL 178 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTE-VSKSLGPGSGIVVW 239 + S I V GISH+ NLP HVAERQA++A + L + V I E S +G GSGI +W Sbjct: 179 EESEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLW 238 Query: 240 AETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG-GE 298 AE + RLG +LGK GK AE VG EAA+ELL ++ G +D+++GDQ+IP++A +G Sbjct: 239 AEGN-TRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSR 297 Query: 299 IWVSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVV 338 + E+T H +TNI + E G+ F ++GE G P ++V+ Sbjct: 298 VRTCELTLHAETNIILSEKITGRRFRVEGERGGPATIEVL 337 >sp|O66884|RTCA_AQUAE PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) >gi|7450877|pir||H70356 conserved hypothetical protein aq_642 - Aquifex aeolicus >gi|2983257|gb|AAC06852.1| (AE000700) hypothetical protein [Aquifex aeolicus] Length = 360 Score = 256 bits (646), Expect = 4e-67 Identities = 154/357 (43%), Positives = 205/357 (57%), Gaps = 25/357 (7%) Query: 2 ITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANA 61 + +DGSYGEGGGQI+RT++ LS + PVRI NIRA R PGL+ QHL+ + LK A A Sbjct: 5 LELDGSYGEGGGQIVRTALFLSTLLQVPVRIYNIRAKREKPGLKRQHLNIVKLLKRFAKA 64 Query: 62 DVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGT 121 VKG +GS EL + P++L+ EVN TAGSI L LQ +LP F V K+ GGT Sbjct: 65 KVKGDELGSIELEYKPQKLKPGYYEVNFDTAGSIPLFLQTILPLSLFVPGEVVIKVIGGT 124 Query: 122 DVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYV------------- 168 DVP SP +D++ V L + K+ +++++RG YP GGGI++ V Sbjct: 125 DVPKSPTIDWVRFVFLHYIYKVPEFIRLEVLKRGFYPAGGGIVQLSVRNKLEKQPENLQE 184 Query: 169 --EPWKERRELVATKYSSIAKVE--GISHATNLPAHVAERQAKAAKEELSKLEVP-VKIK 223 E K++ L T+ I K+ ++H VAERQAK A E L L P ++ Sbjct: 185 VKEYLKDKVNLYRTERGEIRKIHVFSVAHEELRERKVAERQAKGAIEALKNLGYPEPEVY 244 Query: 224 TEVSKSLGPGSGIVVWAE-TDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDK 282 + + + G+ I +W E T LG D LGK+GK AEVVG EA ++L E G VD+ Sbjct: 245 RQYANANSIGTSITIWLEDTKGNVLGADNLGKKGKLAEVVGAEAVKKLHEDWSSGATVDR 304 Query: 283 FLGDQLIPFLAFSGGEIWVSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKVKVVR 339 L D LIP +A GGEI V + T HL TNIWV E FLGK+F++D K K+VR Sbjct: 305 HLADHLIPLMALVGGEIRVPQFTGHLLTNIWVCEQFLGKIFEVD------EKEKIVR 355 >sp|Q9YES0|RTCA_AERPE PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) >gi|7450874|pir||H72747 probable RNA 3'-terminal phosphate cyclase APE0511 - Aeropyrum pernix (strain K1) >gi|5104160|dbj|BAA79476.1| (AP000059) 353aa long hypothetical RNA 3'-terminal phosphate cyclase [Aeropyrum pernix] Length = 353 Score = 255 bits (644), Expect = 6e-67 Identities = 141/347 (40%), Positives = 215/347 (61%), Gaps = 15/347 (4%) Query: 4 IDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANADV 63 +DGS GEGGGQILRT++AL+A+ G P+RI+NIRA R PGLRPQHL + A+ ++ + Sbjct: 1 MDGSMGEGGGQILRTAVALAAVLGRPLRIVNIRAKRRPPGLRPQHLTAVRAVAAISGGRL 60 Query: 64 KGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGTDV 123 +GA VGS L F P R+ + ++GTAGS+ L++QAL P +A++ + VE ++TGGTDV Sbjct: 61 RGAEVGSTSLEFTPGRVRGGRYRFDVGTAGSVALIIQALAPLLAYSDSPVEVELTGGTDV 120 Query: 124 PWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGG-IIEGYVEPWKERRELVATKY 182 P +P +DY+ V L LG I+++RRGHYP+GGG ++ +P R + Sbjct: 121 PMAPTIDYMREVFASILAMLGYEIEIRVLRRGHYPRGGGRVVVRVPDPPGGFRARSFVER 180 Query: 183 SSIAKVEGISHATNLPAHVAERQAKAAKEEL-SKLEVPVKIKTEVSK-----SLGPGSGI 236 + V SHA LP +AERQA++A + +L V ++ E K LGPG+G+ Sbjct: 181 GPLKGVYVRSHAVKLPGSIAERQARSAASLVRERLGVDPIVEIEAYKPHRDPHLGPGTGV 240 Query: 237 VVWAETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG 296 +VWA +GGD++GK+GKPAEVVG+EAA+ LLE + G +D+ + D +LA +G Sbjct: 241 LVWAVFGETVMGGDSIGKKGKPAEVVGREAAESLLEDMATGAALDRHMSDMAPVYLALAG 300 Query: 297 G--EIWVSEVTNHLKTNI----WVVENFLGKVFDLDGEVGKPGKVKV 337 G ++ + +T H T + +V+ F ++ L+G + +P K ++ Sbjct: 301 GVSTVFGARLTGHASTILELLRIMVDGFEYRI--LEGGLERPFKAEL 345 >pir||T13745 hypothetical protein 22E5.3 - fruit fly (Drosophila melanogaster) >gi|3676131|emb|CAA21129.1| (AL031765) /prediction=(method:""genefinder"", version:""084"", score:""51.07"")~/prediction=(method:""genscan"", version:""1.0"", score:""133.97"")~/match=(desc:""RNA 3'-TERMINAL PHOSPHATE CYCLASE 1 (EC 6.5.1.4) (RNA-3'-PHOSPHATE CYCLASE 1) (RNA CYCLA> >gi|7290258|gb|AAF45719.1| (AE003423) EG:22E5.3 gene product [Drosophila melanogaster] Length = 361 Score = 208 bits (523), Expect = 1e-52 Identities = 124/339 (36%), Positives = 191/339 (55%), Gaps = 9/339 (2%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 M+ IDGSY EGGGQ LR +++LS I G+PVR++ IRA+RP+PGL QHLHG+ L+ + N Sbjct: 6 MLEIDGSYLEGGGQALRNALSLSCILGKPVRVVKIRASRPSPGLSHQHLHGLNLLRDITN 65 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 ADV G ++ S + F P+ + V TA SITL+ Q LP + FA ++GG Sbjct: 66 ADVVGNYLLSSTVEFTPRTILDNTYRVETHTAASITLIYQMALPVLLFAGRPSRLIVSGG 125 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 T+V ++PPV+Y+ V L L+ G+ +K+ R G YP+G G + V+P + Sbjct: 126 TNVDFAPPVEYMQEVLLPNLKHFGVSFDLKVQRYGFYPRGQGRCQLDVQPVTKLNSGKLV 185 Query: 181 KYSSIAKVEGISH-ATNLPAHVAERQAKAAKEELSKLEVPVK-----IKTEVSKSLGPGS 234 + I V G+++ A LP ++A + A+ E+ +L + IK K+ G+ Sbjct: 186 AFGRIKSVSGVAYCAGRLPVNIAIDMQQTAQREIHRLWPSQQCSIEPIKHSRQKAFHNGA 245 Query: 235 GIVVWAETDC-LRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLA 293 GI++ T + LG ALGK+ V+G EA+ +L + ++ CVD ++ DQLI ++A Sbjct: 246 GILMTVNTTSDVVLGASALGKKRIDGHVLGSEASCQLGDYMRKQVCVDDYMQDQLIIYMA 305 Query: 294 FSGGE--IWVSEVTNHLKTNIWVVENFLGKVFDLDGEVG 330 + G + ++TNH +T I V E G FD+ E G Sbjct: 306 LAVGRSTMRTGKLTNHTRTAINVAEQMTGVKFDVAMEPG 344 >gi|4506589 RNA 3'-terminal phosphate cyclase [Homo sapiens] >gi|2500648|sp|O00442|RTC1_HUMAN RNA 3'-TERMINAL PHOSPHATE CYCLASE 1 (RNA-3'-PHOSPHATE CYCLASE 1) (RNA CYCLASE 1) >gi|11280306|pir||T48844 RNA-3'-phosphate cyclase (EC 6.5.1.4) 1 [validated] - human >gi|2125812|emb|CAA72364.1| (Y11651) phosphate cyclase [Homo sapiens] Length = 366 Score = 207 bits (522), Expect = 1e-52 Identities = 125/325 (38%), Positives = 186/325 (56%), Gaps = 11/325 (3%) Query: 2 ITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANA 61 + +DGS EGGGQILR S ALS + G P+R+ IRA R PGLRPQHL G+ ++ L + Sbjct: 6 VEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDG 65 Query: 62 DVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGT 121 ++GA +GS E+ F P++++ + TAGS+ L++Q +P + FA + E + GGT Sbjct: 66 QLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGT 125 Query: 122 DVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVATK 181 + +P +DY V +EK G + I RG+YPKGGG + + P K+ + T+ Sbjct: 126 NAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTE 185 Query: 182 YSSIAKVEGISHATN-LPAHVAERQAKAA----KEELSKLEVPVK-IKTEVSKSLGPGSG 235 + K+ G + LP VA+ A AA ++E+ L V ++ ++ ++ G G+G Sbjct: 186 RGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNG 245 Query: 236 IVVWAETD--CLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLA 293 I++ AET CL G +LGKRG A+ VG EAA+ LL L+ G VD++L DQLI F+A Sbjct: 246 IIIIAETSTGCL-FAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMA 304 Query: 294 FSGG--EIWVSEVTNHLKTNIWVVE 316 + G I VT H +T I E Sbjct: 305 LANGVSRIKTGPVTLHTQTAIHFAE 329 >sp|P46849|RTCA_ECOLI RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) Length = 339 Score = 201 bits (505), Expect = 1e-50 Identities = 121/326 (37%), Positives = 178/326 (54%), Gaps = 4/326 (1%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MI +DG+ GEGGGQILR++++LS ITG+P I +IRA R PGL QHL + A + Sbjct: 5 MIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICG 64 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 A V+GA +GS+ L+F P + IG+AGS TLVLQ +LPA+ FA +++GG Sbjct: 65 ATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGG 124 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 TD P +PP D++ V L K+GI ++R G YP GGG++ V P L Sbjct: 125 TDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLG 184 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 + +I ++ G +P HVAER+ S E + + + GPG+ + + Sbjct: 185 ERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIH---NLPRDQGPGNTVSLEV 241 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG-GEI 299 E++ + +G++ AEVV + +E+ L V ++L DQL+ +A +G GE Sbjct: 242 ESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEF 301 Query: 300 WVSEVTNHLKTNIWVVENFLGKVFDL 325 V+ + HL TNI VVE FL F L Sbjct: 302 TVAHPSCHLLTNIAVVERFLPVRFSL 327 >pdb|1QMH|B Chain B, Crystal Structure Of Rna 3'-Terminal Phosphate Cyclase, An Ubiquitous Enzyme With Unusual Topology >gi|6980697|pdb|1QMH|A Chain A, Crystal Structure Of Rna 3'-Terminal Phosphate Cyclase, An Ubiquitous Enzyme With Unusual Topology Length = 347 Score = 201 bits (505), Expect = 1e-50 Identities = 121/326 (37%), Positives = 178/326 (54%), Gaps = 4/326 (1%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MI +DG+ GEGGGQILR++++LS ITG+P I +IRA R PGL QHL + A + Sbjct: 5 MIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICG 64 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 A V+GA +GS+ L+F P + IG+AGS TLVLQ +LPA+ FA +++GG Sbjct: 65 ATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGG 124 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 TD P +PP D++ V L K+GI ++R G YP GGG++ V P L Sbjct: 125 TDNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLG 184 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 + +I ++ G +P HVAER+ S E + + + GPG+ + + Sbjct: 185 ERGNIVQMRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIH---NLPRDQGPGNTVSLEV 241 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG-GEI 299 E++ + +G++ AEVV + +E+ L V ++L DQL+ +A +G GE Sbjct: 242 ESENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEF 301 Query: 300 WVSEVTNHLKTNIWVVENFLGKVFDL 325 V+ + HL TNI VVE FL F L Sbjct: 302 TVAHPSCHLLTNIAVVERFLPVRFSL 327 >pdb|1QMI|A Chain A, Crystal Structure Of Rna 3'-Terminal Phosphate Cyclase, An Ubiquitous Enzyme With Unusual Topology >gi|6980700|pdb|1QMI|B Chain B, Crystal Structure Of Rna 3'-Terminal Phosphate Cyclase, An Ubiquitous Enzyme With Unusual Topology >gi|6980701|pdb|1QMI|C Chain C, Crystal Structure Of Rna 3'-Terminal Phosphate Cyclase, An Ubiquitous Enzyme With Unusual Topology >gi|6980702|pdb|1QMI|D Chain D, Crystal Structure Of Rna 3'-Terminal Phosphate Cyclase, An Ubiquitous Enzyme With Unusual Topology Length = 347 Score = 197 bits (496), Expect = 1e-49 Identities = 120/325 (36%), Positives = 175/325 (52%), Gaps = 4/325 (1%) Query: 2 ITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANA 61 I +DG+ GEGGGQILR++++LS ITG+P I +IRA R PGL QHL + A + A Sbjct: 6 IALDGAQGEGGGQILRSALSLSXITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICGA 65 Query: 62 DVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGT 121 V+GA +GS+ L+F P + IG+AGS TLVLQ +LPA+ FA +++GGT Sbjct: 66 TVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSGGT 125 Query: 122 DVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVATK 181 D P +PP D++ V L K+GI ++R G YP GGG++ V P L + Sbjct: 126 DNPSAPPADFIRRVLEPLLAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGE 185 Query: 182 YSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWAE 241 +I + G +P HVAER+ S E + + + GPG+ + + E Sbjct: 186 RGNIVQXRGEVLLAGVPRHVAEREIATLAGSFSLHEQNIH---NLPRDQGPGNTVSLEVE 242 Query: 242 TDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG-GEIW 300 ++ + +G++ AEVV + +E+ L V ++L DQL+ A +G GE Sbjct: 243 SENITERFFVVGEKRVSAEVVAAQLVKEVKRYLASTAAVGEYLADQLVLPXALAGAGEFT 302 Query: 301 VSEVTNHLKTNIWVVENFLGKVFDL 325 V+ + HL TNI VVE FL F L Sbjct: 303 VAHPSCHLLTNIAVVERFLPVRFSL 327 >pir||E83072 RNA 3'-terminal phosphate cyclase PA4585 [imported] - Pseudomonas aeruginosa (strain PAO1) >gi|9950833|gb|AAG07973.1|AE004872_4 (AE004872) RNA 3'-terminal phosphate cyclase [Pseudomonas aeruginosa] Length = 341 Score = 181 bits (455), Expect = 9e-45 Identities = 109/320 (34%), Positives = 179/320 (55%), Gaps = 5/320 (1%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 +I +DGS EGGGQILR++++LS +G+P+RI NIR R PGL QHL + A + Sbjct: 5 LIELDGS--EGGGQILRSALSLSMTSGQPLRIRNIRGRRSRPGLLRQHLTAVRAAAEICA 62 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 A+V+GA +GSREL F P + A IG+AGS +LVLQ LLPA+ A +I+GG Sbjct: 63 AEVEGAELGSRELAFRPGAIRAGDYAFAIGSAGSCSLVLQTLLPALLAANGESRVRISGG 122 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVAT 180 T P +PP D+L + L L+++G ++++R G P GGG + V P R L Sbjct: 123 THNPLAPPADFLRDSWLPLLQRMGAEVDLELLRHGFVPAGGGELLARVRP-ARWRPLQLE 181 Query: 181 KYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWA 240 + + + + +P HV ER+ + ++ L + +++ +++ GPG+ +++ Sbjct: 182 HPGAALRRQARALLAGIPGHVGERELERVRQRLGWSDEERQLEF-LAEDQGPGNALLLRI 240 Query: 241 ETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG-GEI 299 + + + A G+ G AE V ++ A + + ++ G D+ L DQL+ +A +G G Sbjct: 241 DCEHICATFCAFGQAGVSAERVAEQVATQAIGWMESGCAADEHLADQLLLPMALAGAGSF 300 Query: 300 WVSEVTNHLKTNIWVVENFL 319 ++ HL++N V+E FL Sbjct: 301 TTPRLSAHLQSNRRVIERFL 320 >sp|O15746|RTC1_DICDI PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE 1 (RNA-3'-PHOSPHATE CYCLASE 1) (RNA CYCLASE 1) >gi|2425127|gb|AAB70847.1| (AF020279) similar to H. sapiens phosphate cyclase encoded by GenBank Accession Number Y11651 [Dictyostelium discoideum] Length = 433 Score = 175 bits (439), Expect = 7e-43 Identities = 119/336 (35%), Positives = 181/336 (53%), Gaps = 15/336 (4%) Query: 4 IDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANADV 63 IDGS EGGGQILR S+AL+++ + + I IR NR PGL+ QH GI + L A + Sbjct: 38 IDGSILEGGGQILRNSVALASLFNKAISIEKIRYNRDQPGLKNQHKAGIDLMSRLFKAHL 97 Query: 64 KGAHVGSRELVFIPKRLEAKK---VEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 G VGS +L + P + + +E + TAGSI L++Q LP + FA + + + GG Sbjct: 98 TGCSVGSCKLYYQPTQKTIQDDGVIEADTKTAGSICLMIQVSLPCLIFAPHSTKMVLGGG 157 Query: 121 TDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKE-RRELVA 179 T+ ++P DY+ NV L +G + I +RG YPKGGG + +P + + Sbjct: 158 TNCDFAPAADYIQNVFLPIATTMGFKCEMSIDKRGFYPKGGGAVTLTTQPLTQPLSPITI 217 Query: 180 TKYSSIAKVEGISHATN--LPAHVAERQAKAAKEELSKLEVPVKIKTE---VSK-SLGPG 233 + ++ S+ T+ + VAER AK+ + K V ++TE VSK S G G Sbjct: 218 VNKGEVNRIVIKSYFTSPRISPLVAERMNNTAKKLIKKDFKKVDVETELIDVSKFSFGDG 277 Query: 234 SGIVVWAETD--CLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPF 291 + I + A TD C+ G G G PAE V ++AA LL+ L+ G C+D++L DQLI F Sbjct: 278 TFIEIRAYTDQGCI-FGATGNGAIGVPAEKVAEDAANSLLKDLQDGGCMDEYLQDQLIIF 336 Query: 292 LAFSGG--EIWVSEVTNHLKTNIWVVENFLGKVFDL 325 +A + G +I ++ H +T+I + G +F + Sbjct: 337 MALAKGKSQIKTGPISLHTQTSIHITSLMTGAIFTI 372 >gb|AAG19210.1| (AE005017) RNA 3'-terminal phosphate cyclase; Tpc [Halobacterium sp. NRC-1] Length = 378 Score = 173 bits (435), Expect = 2e-42 Identities = 123/355 (34%), Positives = 182/355 (50%), Gaps = 40/355 (11%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 M +DGS GGGQ++RT++ +A++GE R+ +R R NPGL+ QH + A+ + + Sbjct: 40 MHVLDGS--SGGGQLVRTALTCAAVSGESFRMRYVRRARSNPGLQAQHCAAVNAVADICD 97 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVE------------VNIGTAGSITLVLQALLPAMAF 108 A G VGS F P+ + A++ + V +GTAGSI LV +LLP Sbjct: 98 AATDGVEVGSEAFSFEPE-VAAEEADDDEEPTLGGTTSVEVGTAGSIPLVFDSLLPLAGA 156 Query: 109 AKNRVEFKITGGTDVPWSPPVDYLANVTLFALEKLGIMAGIKIVRRGHYPKGGGIIEGYV 168 + +TGGTD W+PP+DY +V L L + GI A + + RRG YP+GGG V Sbjct: 157 LDEPITATLTGGTDAKWAPPMDYFQHVKLPLLREHGIDATVSVDRRGFYPRGGGEATLTV 216 Query: 169 EP-------WKERRELVA-TKYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPV 220 EP ER + A T YS ++ ++ VAE+QA AA + + Sbjct: 217 EPSTPTPITLTERGDREALTAYS-------VAESSLADDEVAEQQATAAAPDAAH----- 264 Query: 221 KIKTEVSKSLGPGSGIVVWAETDCLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCV 280 + + + GS +V+ AE + R G ALG+RG A+ VG+ AA L V Sbjct: 265 --EIAYTDADSAGSAVVLAAEYEHSRAGFAALGERGVSADAVGENAADALAAFESGPGAV 322 Query: 281 DKFLGDQLIPFLAFSGGEIWVSEVTNHLKTNIWVVENFLGKVFDLDGEVGKPGKV 335 D L DQL+P +A +GGE+ EVT H++T + ++ F +D+D E G V Sbjct: 323 DSHLADQLVPVVAVAGGEVRAPEVTTHIETCVDLLAEF---DYDIDIEHTDDGAV 374 >pir||G65137 hypothetical 15.4 kD protein in malT-glpR intergenic region - Escherichia coli (strain K-12) >gi|606355|gb|AAA58218.1| (U18997) ORF_f146 [Escherichia coli] >gi|1789826|gb|AAC76445.1| (AE000418) RNA 3'-terminal phosphate cyclase [Escherichia coli K12] Length = 146 Score = 117 bits (291), Expect = 2e-25 Identities = 60/128 (46%), Positives = 82/128 (63%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 MI +DG+ GEGGGQILR++++LS ITG+P I +IRA R PGL QHL + A + Sbjct: 5 MIALDGAQGEGGGQILRSALSLSMITGQPFTITSIRAGRAKPGLLRQHLTAVKAATEICG 64 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 A V+GA +GS+ L+F P + IG+AGS TLVLQ +LPA+ FA +++ Sbjct: 65 ATVEGAELGSQRLLFRPGTVRGGDYRFAIGSAGSCTLVLQTVLPALWFADGPSRVEVSAA 124 Query: 121 TDVPWSPP 128 TD P +PP Sbjct: 125 TDNPSAPP 132 >emb|CAB89811.1| (AJ276894) RNA 3'-terminal phosphate cyclase-like protein [Homo sapiens] Length = 373 Score = 96.0 bits (235), Expect = 6e-19 Identities = 92/317 (29%), Positives = 142/317 (44%), Gaps = 15/317 (4%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 M T S G LR + LS ++G PV+I IRA NPGLR I L + N Sbjct: 1 MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITN 60 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 + L + P L VE + I L++LL F K+ ++ + G Sbjct: 61 GSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGV 120 Query: 121 TDVPWSPPVDYLANVTLFALEKLGI---MAGIKIVRRGHYPKGGGIIEGYVEPWKERREL 177 T+ P VD L L L++ GI +KIVRRG P GGG + K + + Sbjct: 121 TNDQVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPI 180 Query: 178 VATKYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTE----VSKSLGPG 233 T I ++ G++++ + +A R +A+ L+K + I T+ V+ PG Sbjct: 181 QLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPG 240 Query: 234 SGIVVWAETDC-LRLGGD-ALGKRGKPAEV----VGKEAAQELLEQLKPGYCVDKFLGDQ 287 G+ + AET L + A +G+ A V +G+ A+ LLE++ G CVD +Q Sbjct: 241 FGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDS--TNQ 298 Query: 288 LIPFLAFSGGEIWVSEV 304 + L + G+ VS+V Sbjct: 299 SLALLLMTLGQRDVSKV 315 >gi|10946950 RNA cyclase homolog; RNA 3'-terminal phosphate cyclase-like protein [Mus musculus] >gi|7688275|emb|CAB89817.1| (AJ276895) RNA 3'-terminal phosphate cyclase-like protein [Mus musculus] Length = 373 Score = 96.0 bits (235), Expect = 6e-19 Identities = 93/317 (29%), Positives = 143/317 (44%), Gaps = 15/317 (4%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 M T S G LR + LS ++G PV+I IRA NPGLR I L + N Sbjct: 1 MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRRIRARDDNPGLRDFEASFIRLLDKITN 60 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 + L + P L VE + I L+ALL F K+ ++ + G Sbjct: 61 GSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLEALLCLAPFMKHPLKIVLRGV 120 Query: 121 TDVPWSPPVDYLANVTLFALEKLGI---MAGIKIVRRGHYPKGGGIIEGYVEPWKERREL 177 T+ P VD L L L++ GI +KI+RRG P GGG + K + + Sbjct: 121 TNDQVDPSVDVLKATALPLLKQFGIDGESFELKILRRGMPPGGGGEVLFSCPVRKVLKPV 180 Query: 178 VATKYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTE----VSKSLGPG 233 T I ++ G++++ + +A R +A+ L+K + I T+ VS PG Sbjct: 181 QLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVSSGKSPG 240 Query: 234 SGIVVWAE-TDCLRLGGD-ALGKRGKPAEV----VGKEAAQELLEQLKPGYCVDKFLGDQ 287 G+ + AE T+ L + A +G+ A V +G+ A+ LLE++ G CVD +Q Sbjct: 241 FGLSLVAETTNGTFLSAELASNPQGQGAAVLPEDLGRNCAKLLLEEIYRGGCVDS--TNQ 298 Query: 288 LIPFLAFSGGEIWVSEV 304 + L + G+ VS+V Sbjct: 299 SLVLLLMTLGQQDVSKV 315 >gi|11429125 RNA cyclase homolog [Homo sapiens] Length = 366 Score = 94.8 bits (232), Expect = 1e-18 Identities = 89/306 (29%), Positives = 139/306 (45%), Gaps = 15/306 (4%) Query: 12 GGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANADVKGAHVGSR 71 G LR + LS ++G PV+I IRA NPGLR I L + N + Sbjct: 5 GCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGT 64 Query: 72 ELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGTDVPWSPPVDY 131 L + P L VE + I L++LL F K+ ++ + G T+ P VD Sbjct: 65 TLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGVTNDQVDPSVDV 124 Query: 132 LANVTLFALEKLGI---MAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVATKYSSIAKV 188 L L L++ GI +KIVRRG P GGG + K + + T I ++ Sbjct: 125 LKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPIQLTDPGKIKRI 184 Query: 189 EGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTE----VSKSLGPGSGIVVWAETDC 244 G++++ + +A R +A+ L+K + I T+ V+ PG G+ + AET Sbjct: 185 RGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTS 244 Query: 245 -LRLGGD-ALGKRGKPAEV----VGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGE 298 L + A +G+ A V +G+ A+ LLE++ G CVD +Q + L + G+ Sbjct: 245 GTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDS--TNQSLALLLMTLGQ 302 Query: 299 IWVSEV 304 VS+V Sbjct: 303 QDVSKV 308 >dbj|BAB14300.1| (AK022904) unnamed protein product [Homo sapiens] Length = 373 Score = 93.6 bits (229), Expect = 3e-18 Identities = 91/317 (28%), Positives = 141/317 (43%), Gaps = 15/317 (4%) Query: 1 MITIDGSYGEGGGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLAN 60 M T S G LR + LS ++G PV+I IRA NPGLR I L + N Sbjct: 1 MATQAYSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITN 60 Query: 61 ADVKGAHVGSRELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGG 120 + L + P L VE + I L++LL F K+ ++ + G Sbjct: 61 GSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGV 120 Query: 121 TDVPWSPPVDYLANVTLFALEKLGI---MAGIKIVRRGHYPKGGGIIEGYVEPWKERREL 177 T+ P VD L L L++ GI + IVRRG P GGG + K + + Sbjct: 121 TNDQVDPSVDVLKATALPLLKQFGIDGESFELNIVRRGMPPGGGGEVVFSCPVRKVLKPI 180 Query: 178 VATKYSSIAKVEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTE----VSKSLGPG 233 T I ++ G++++ + +A R +A+ L+K + I T+ V+ PG Sbjct: 181 QLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPG 240 Query: 234 SGIVVWAETDC-LRLGGD-ALGKRGKPAEV----VGKEAAQELLEQLKPGYCVDKFLGDQ 287 G+ + AET L + A +G+ A V +G+ A+ LLE++ G CVD +Q Sbjct: 241 FGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDS--TNQ 298 Query: 288 LIPFLAFSGGEIWVSEV 304 + L + G+ VS+V Sbjct: 299 SLALLLMTLGQQDVSKV 315 >sp|Q23400|RTC2_CAEEL PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) Length = 379 Score = 89.3 bits (218), Expect = 6e-17 Identities = 78/284 (27%), Positives = 126/284 (43%), Gaps = 14/284 (4%) Query: 12 GGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANADVKGAHVGSR 71 G R +A S ++G P+RIINIR N PG+R I L+ + N Sbjct: 10 GCNFFRIRLAYSILSGRPIRIINIRKNDDRPGIRDFESKLIGLLEKVTNGTKVEISRTGT 69 Query: 72 ELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGTDVPWSPPVDY 131 +++F P + V ++ GT I+ L+ LL F K + K+ G T+ P VD Sbjct: 70 QVIFRPGMITGGVVNLDCGTERCISYFLEPLLLLSPFCKVPMVIKLKGVTNAPGEISVDG 129 Query: 132 LANVTLFALEKLGI---MAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVATKYSSIAKV 188 + L K + IKI RG P+GGG++ K R + + + K+ Sbjct: 130 MKASWLKVYNKFVLNDEKLDIKIQARGLKPEGGGVVVFTAPIVKTLRPVKRQQVGKVCKI 189 Query: 189 EGISHATNLPAHVAERQAKAAKEE----LSKLEVPVKIKTEVSKSLGPGSGIVVWAE-TD 243 G ++ T + +A R AAK+ +S + + V + + PG G+ + AE T+ Sbjct: 190 RGQAYVTKVTPSLAYRMIDAAKKAMHGYISDVYITVDQRKGDAGGASPGYGLFLTAETTE 249 Query: 244 CLRLGGDAL----GKRGKP--AEVVGKEAAQELLEQLKPGYCVD 281 + +A+ G+ G P E +G EA LL+Q+ G +D Sbjct: 250 GVIYQAEAISRPKGESGVPILPEDIGIEAGHALLQQIYMGGALD 293 >sp|Q09870|RTC1_SCHPO PROBABLE RNA 3'-TERMINAL PHOSPHATE CYCLASE (RNA-3'-PHOSPHATE CYCLASE) (RNA CYCLASE) >gi|2130253|pir||S62537 probable RNA 3'-terminal phosphate cyclase - fission yeast (Schizosaccharomyces pombe) >gi|1052524|emb|CAA91501.1| (Z66568) probable RNA 3'-terminal phosphate cyclase [Schizosaccharomyces pombe] Length = 363 Score = 87.0 bits (212), Expect = 3e-16 Identities = 72/297 (24%), Positives = 132/297 (44%), Gaps = 9/297 (3%) Query: 12 GGQILRTSIALSAITGEPVRIINIRANRPNPGLRPQHLHGILALKHLANADVKGAHVGSR 71 G + L + L+ ++G P+R+ I + +PG++ + + L+ L N V Sbjct: 11 GCEYLTHRLVLATLSGTPIRVEGIYPDEADPGVKDYQVSFLRLLEKLTNGSVIEISYTGT 70 Query: 72 ELVFIPKRLEAKKVEVNIGTAGSITLVLQALLPAMAFAKNRVEFKITGGTDVPWSPPVDY 131 ++ P + +V + T I L+ +L FAK +TG T VD Sbjct: 71 SFIYRPGNIIGGRVVHDCPTTKGIGYFLEPILILCLFAKTPTSLTLTGVTSSNEDIGVDV 130 Query: 132 LANVTLFALEK---LGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELV-ATKYSSIAK 187 L L +L+K +G ++I++RG P GGG + KE + +++ + + Sbjct: 131 LRTSVLPSLQKRFQVGDELELRILKRGSAPGGGGEVNFLCPVIKESLPPIRLSEFGRVFR 190 Query: 188 VEGISHATNLPAHVAERQAKAAKEELSKLEVPVKIKTEVSK----SLGPGSGIVVWAETD 243 + GI+ +T + A R ++A+ L+ V I T+V + PG I + AET+ Sbjct: 191 IRGIASSTRVSPAFANRLVESARGVLNPFIPDVFIYTDVRRGDECGNSPGYSITLVAETN 250 Query: 244 -CLRLGGDALGKRGKPAEVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSGGEI 299 + G+ G+ E VG A++LLE ++ G CVD + + + S ++ Sbjct: 251 KGCSYAAEHCGEAGETPEDVGSFCAKKLLEVIESGGCVDPYTQPSTLTGMLLSSEDV 307 >pir||F65137 hypothetical 21.7 kD protein in malT-glpR intergenic region - Escherichia coli (strain K-12) >gi|606354|gb|AAA58217.1| (U18997) ORF_f201 [Escherichia coli] >gi|1789825|gb|AAC76444.1| (AE000418) orf, hypothetical protein [Escherichia coli K12] Length = 201 Score = 81.1 bits (197), Expect = 2e-14 Identities = 57/187 (30%), Positives = 90/187 (47%), Gaps = 4/187 (2%) Query: 140 LEKLGIMAGIKIVRRGHYPKGGGIIEGYVEPWKERRELVATKYSSIAKVEGISHATNLPA 199 L K+GI ++R G YP GGG++ V P L + +I ++ G +P Sbjct: 6 LAKIGIHQQTTLLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPR 65 Query: 200 HVAERQAKAAKEELSKLEVPVKIKTEVSKSLGPGSGIVVWAETDCLRLGGDALGKRGKPA 259 HVAER+ S E + + + GPG+ + + E++ + +G++ A Sbjct: 66 HVAEREIATLAGSFSLHEQNIH---NLPRDQGPGNTVSLEVESENITERFFVVGEKRVSA 122 Query: 260 EVVGKEAAQELLEQLKPGYCVDKFLGDQLIPFLAFSG-GEIWVSEVTNHLKTNIWVVENF 318 EVV + +E+ L V ++L DQL+ +A +G GE V+ + HL TNI VVE F Sbjct: 123 EVVAAQLVKEVKRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERF 182 Query: 319 LGKVFDL 325 L F L Sbjct: 183 LPVRFSL 189 >gb|AAA83889.1| (M13585) ORFX; putative [Escherichia coli] Length = 191 Score = 76.1 bits (184), Expect = 6e-13 Identities = 53/176 (30%), Positives = 85/176 (48%), Gaps = 4/176 (2%) Query: 151 IVRRGHYPKGGGIIEGYVEPWKERRELVATKYSSIAKVEGISHATNLPAHVAERQAKAAK 210 ++R G YP GGG++ V P L + +I ++ G +P HVAER+ Sbjct: 7 LLRHGFYPAGGGVVATEVSPVASFNTLQLGERGNIVQMRGEVLLAGVPRHVAEREIATLA 66 Query: 211 EELSKLEVPVKIKTEVSKSLGPGSGIVVWAETDCLRLGGDALGKRGKPAEVVGKEAAQEL 270 S E + + + GPG+ + + E++ + +G++ AEVV + +E+ Sbjct: 67 GSFSLHEQNIH---NLPRDQGPGNTVSLEVESENITERFFVVGEKRVSAEVVAAQLVKEV 123 Query: 271 LEQLKPGYCVDKFLGDQLIPFLAFSG-GEIWVSEVTNHLKTNIWVVENFLGKVFDL 325 L V ++L DQL+ +A +G GE V+ + HL TNI VVE FL F L Sbjct: 124 KRYLASTAAVGEYLADQLVLPMALAGAGEFTVAHPSCHLLTNIAVVERFLPVRFSL 179 Database: ./suso.pep Posted date: Jul 6, 2001 5:57 PM Number of letters in database: 840,471 Number of sequences in database: 2977 Database: /banques/blast2/nr.pep Posted date: Dec 14, 2000 12:46 PM Number of letters in database: 188,266,275 Number of sequences in database: 595,510 Lambda K H 0.317 0.138 0.403 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 130736172 Number of Sequences: 2977 Number of extensions: 5475968 Number of successful extensions: 12191 Number of sequences better than 1.0e-10: 26 Number of HSP's better than 0.0 without gapping: 17 Number of HSP's successfully gapped in prelim test: 9 Number of HSP's that attempted gapping in prelim test: 12127 Number of HSP's gapped (non-prelim): 26 length of query: 342 length of database: 189,106,746 effective HSP length: 55 effective length of query: 287 effective length of database: 156,189,961 effective search space: 44826518807 effective search space used: 44826518807 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.6 bits) S2: 165 (68.7 bits)