BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1982 (deoA) DE:thymidine phosphorylase (deoA)
(507 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||H75175 thymidine phosphorylase (deoa) PAB1982 - Pyrococcus ... 987 0.0
pir||F71038 probable pyrimidine-nucleoside phosphorylase - Pyroc... 916 0.0
gi|11498939 thymidine phosphorylase (deoA-1) [Archaeoglobus fulg... 509 e-143
sp|Q58081|TYPH_METJA PUTATIVE THYMIDINE PHOSPHORYLASE (TDRPASE) ... 505 e-142
gi|11498940 thymidine phosphorylase (deoA-2) [Archaeoglobus fulg... 436 e-121
pdb|1BRW|B Chain B, The Crystal Structure Of Pyrimidine Nucleosi... 215 7e-55
pir||B72228 pyrimidine-nucleoside phosphorylase - Thermotoga mar... 203 3e-51
sp|O53366|DEOA_MYCTU THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|74339... 201 1e-50
dbj|BAB05252.1| (AP001512) pyrimidine-nucleoside phosphorylase [... 192 7e-48
sp|P77836|PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) >... 189 8e-47
pir||A75520 pyrimidine-nucleoside phosphorylase - Deinococcus ra... 187 2e-46
sp|P39142|PDP_BACSU PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) >... 182 8e-45
gb|AAD17954.1| (AF105341) pyrimidine nucleoside phosphorylase [L... 181 2e-44
sp|P19971|TYPH_HUMAN THYMIDINE PHOSPHORYLASE PRECURSOR (TDRPASE)... 176 5e-43
gi|4503445 endothelial cell growth factor 1 (platelet-derived) [... 176 5e-43
sp|P47717|TYPH_MYCPI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|10862... 147 2e-34
pir||E82087 thymidine phosphorylase VC2349 [imported] - Vibrio c... 146 5e-34
sp|P47297|TYPH_MYCGE THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|13618... 144 2e-33
pdb|2TPT| Structural And Theoretical Studies Suggest Domain Mo... 142 1e-32
sp|P07650|TYPH_ECOLI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|13612... 142 1e-32
pir||A37131 thymidine phosphorylase (EC 2.4.2.4) - Escherichia coli 140 4e-32
pir||C82899 thymidine phosphorylase UU368 [imported] - Ureaplasm... 138 2e-31
sp|P75052|TYPH_MYCPN THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|21466... 133 4e-30
sp|P43050|TYPH_MYCHO THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|62935... 110 3e-23
gb|AAC44438.1| (U67196) thymidine/pyrimidine phosphorylase homol... 76 1e-12
>pir||H75175 thymidine phosphorylase (deoa) PAB1982 - Pyrococcus abyssi (strain
Orsay) >gi|5457997|emb|CAB49487.1| (AJ248284) thymidine
phosphorylase (deoA) [Pyrococcus abyssi]
Length = 507
Score = 987 bits (2524), Expect = 0.0
Identities = 507/507 (100%), Positives = 507/507 (100%)
Query: 1 MVFVMRAKVRILNIRSGHFDVFINPKDAQEWKLHPNDLVKIESGKRSIYGSVVIGDFVES 60
MVFVMRAKVRILNIRSGHFDVFINPKDAQEWKLHPNDLVKIESGKRSIYGSVVIGDFVES
Sbjct: 1 MVFVMRAKVRILNIRSGHFDVFINPKDAQEWKLHPNDLVKIESGKRSIYGSVVIGDFVES 60
Query: 61 GEVGLSLDILDAYQFSEGELVSITPSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRK 120
GEVGLSLDILDAYQFSEGELVSITPSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRK
Sbjct: 61 GEVGLSLDILDAYQFSEGELVSITPSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRK 120
Query: 121 LRNTEISALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNI 180
LRNTEISALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNI
Sbjct: 121 LRNTEISALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNI 180
Query: 181 IVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEKIGACLVWGGA 240
IVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEKIGACLVWGGA
Sbjct: 181 IVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEKIGACLVWGGA 240
Query: 241 LNLAPADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEAR 300
LNLAPADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEAR
Sbjct: 241 LNLAPADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEAR 300
Query: 301 SLAKDFIELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALG 360
SLAKDFIELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALG
Sbjct: 301 SLAKDFIELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALG 360
Query: 361 LAGILLEMGGVAPRGMGKKVAREILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYT 420
LAGILLEMGGVAPRGMGKKVAREILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYT
Sbjct: 361 LAGILLEMGGVAPRGMGKKVAREILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYT 420
Query: 421 IHAQTSGYVTGIDNKAITAIAREAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESR 480
IHAQTSGYVTGIDNKAITAIAREAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESR
Sbjct: 421 IHAQTSGYVTGIDNKAITAIAREAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESR 480
Query: 481 LDKAIILARRLEPIKIEGMVLQVLGNL 507
LDKAIILARRLEPIKIEGMVLQVLGNL
Sbjct: 481 LDKAIILARRLEPIKIEGMVLQVLGNL 507
>pir||F71038 probable pyrimidine-nucleoside phosphorylase - Pyrococcus
horikoshii >gi|3258027|dbj|BAA30710.1| (AP000006) 503aa
long hypothetical pyrimidine-nucleoside phosphorylase
[Pyrococcus horikoshii]
Length = 503
Score = 916 bits (2341), Expect = 0.0
Identities = 459/503 (91%), Positives = 487/503 (96%)
Query: 5 MRAKVRILNIRSGHFDVFINPKDAQEWKLHPNDLVKIESGKRSIYGSVVIGDFVESGEVG 64
MRAKV+IL I++G F+VFI+P+DA+EWKLHPNDLVKIESGKRSIY SV IGDF+E GEVG
Sbjct: 1 MRAKVKILKIKTGSFNVFISPRDAEEWKLHPNDLVKIESGKRSIYASVAIGDFIEDGEVG 60
Query: 65 LSLDILDAYQFSEGELVSITPSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNT 124
LS DIL +YQFSEGE+VSITPS TPESV+YIKKKM+GEKLRKVEIETI+RDIVDRKLRNT
Sbjct: 61 LSQDILSSYQFSEGEVVSITPSGTPESVKYIKKKMKGEKLRKVEIETIIRDIVDRKLRNT 120
Query: 125 EISALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNIIVVP 184
EISA +TAIE+NGL MDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNI+VVP
Sbjct: 121 EISAFITAIEINGLSMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNILVVP 180
Query: 185 IVAAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEKIGACLVWGGALNLA 244
IVAAAGLTIPKTSSRAITSAAGTADVVEV TNV LSLDEIKRIVEKIGACLVWGGALNLA
Sbjct: 181 IVAAAGLTIPKTSSRAITSAAGTADVVEVLTNVKLSLDEIKRIVEKIGACLVWGGALNLA 240
Query: 245 PADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAK 304
PADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETM+EAR+LAK
Sbjct: 241 PADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMDEARTLAK 300
Query: 305 DFIELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGI 364
DFIELGKKLGQYVEVAITYGGQPIGY +GPALEAKEALETLMTGKGPGSLVEKA GLAGI
Sbjct: 301 DFIELGKKLGQYVEVAITYGGQPIGYAIGPALEAKEALETLMTGKGPGSLVEKATGLAGI 360
Query: 365 LLEMGGVAPRGMGKKVAREILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYTIHAQ 424
LLEMGGVAP+GMGKKVA+EILESGKAYEK+KEIIEEQGGDPNIKPEDIPIGDKTYTIHAQ
Sbjct: 361 LLEMGGVAPKGMGKKVAKEILESGKAYEKMKEIIEEQGGDPNIKPEDIPIGDKTYTIHAQ 420
Query: 425 TSGYVTGIDNKAITAIAREAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKA 484
T GYVTGIDN+AITAIAREAGAPEDKGAGV+LHVKVGEKVKEGDPL TIHAESESRL+KA
Sbjct: 421 TGGYVTGIDNRAITAIAREAGAPEDKGAGVRLHVKVGEKVKEGDPLITIHAESESRLEKA 480
Query: 485 IILARRLEPIKIEGMVLQVLGNL 507
I+LARRLEPIKIEGMVLQV+GN+
Sbjct: 481 IVLARRLEPIKIEGMVLQVIGNI 503
>gi|11498939 thymidine phosphorylase (deoA-1) [Archaeoglobus fulgidus]
>gi|7427933|pir||D69417 probable thymidine phosphorylase
(EC 2.4.2.4) 1 - Archaeoglobus fulgidus
>gi|2649233|gb|AAB89903.1| (AE001011) thymidine
phosphorylase (deoA-1) [Archaeoglobus fulgidus]
Length = 504
Score = 509 bits (1296), Expect = e-143
Identities = 263/492 (53%), Positives = 346/492 (69%), Gaps = 3/492 (0%)
Query: 15 RSGHFDVFINPKDAQEWKLHPNDLVKIESGKRSIYGSVVIG-DFVESGEVGLSLDILDAY 73
+SG F V +N +DA E + D V++ GK + +V I + VE G VGL+
Sbjct: 11 KSGRFAVILNEEDASELGVREGDRVRVRYGKAGVVATVQITREIVEKGFVGLTDLASMEL 70
Query: 74 QFSEGELVSITPSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAI 133
S+G V + PS P+SV IKKK RGEKL + EI IV DI + L E++A V +
Sbjct: 71 GISDGAEVDVFPSPKPKSVELIKKKTRGEKLSQDEIRRIVEDITNNALSEVELTAFVISS 130
Query: 134 EVNGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTI 193
+ G+D DEI LT +M ETG+ ++ DR ++D HSIGGVPGNK ++++VP VAAAGL I
Sbjct: 131 MLRGMDFDEIEWLTRSMIETGERIEFDRGTVVDKHSIGGVPGNKISLLIVPTVAAAGLLI 190
Query: 194 PKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHV 253
PKT+SRAITSA+GTAD +EV NV LS+DEIK I E++G + WGGA N+APADD I V
Sbjct: 191 PKTASRAITSASGTADTMEVLANVNLSVDEIKEITERVGGVIAWGGATNIAPADDKIIRV 250
Query: 254 ERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKL 313
E LS+DPR +LAS+M+KK ++G+++++IDIP G+GAK+E +E RSLA DFIELG++L
Sbjct: 251 EHPLSIDPRPQLLASVMAKKGSVGAKHVVIDIPVGEGAKIEKVEVGRSLANDFIELGRRL 310
Query: 314 GQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAP 373
G V AITYGGQP+G +GPALEA+EAL+T+ +GP SLVEK+LG+AGIL EM G+A
Sbjct: 311 GLNVMAAITYGGQPVGRAIGPALEAREALKTMEDRRGPSSLVEKSLGIAGILFEMTGIAT 370
Query: 374 RGMGKKVAREILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYTIHAQTSGYVTGID 433
G + AR+I ESGK EK +EI+ QGGD ++K ED+ +GDKTYT+ +Q G V ++
Sbjct: 371 NGY--QHARKIFESGKTLEKFREIVAAQGGDESVKAEDVAVGDKTYTLTSQVEGAVVSVN 428
Query: 434 NKAITAIAREAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKAIILARRLEP 493
NK+I IAR AGAP+DKGAGV +H K GE VK GDPL TI+AE E +LD AI +A P
Sbjct: 429 NKSIVKIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAIEVANTERP 488
Query: 494 IKIEGMVLQVLG 505
I + GMVL+V G
Sbjct: 489 IVVSGMVLEVYG 500
>sp|Q58081|TYPH_METJA PUTATIVE THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|2129307|pir||C64383
thymidine phosphorylase (EC 2.4.2.4) - Methanococcus
jannaschii >gi|1591381|gb|AAB98662.1| (U67514) thymidine
phosphorylase (deoA) [Methanococcus jannaschii]
Length = 503
Score = 505 bits (1286), Expect = e-142
Identities = 274/497 (55%), Positives = 360/497 (72%), Gaps = 5/497 (1%)
Query: 8 KVRILNIRSGHFDVFINPKDAQEWKLHPNDLVKIESGKRSIYGSVVIGD-FVESGEVGLS 66
KVR+L+I + V IN +D + + P D V +E + + G + + GE+GL
Sbjct: 5 KVRVLDIDLENL-VLINSEDLKSSQYFPQDRVVVEFKGKEVIGILHSSTTLINRGEIGLP 63
Query: 67 LDILDAYQFSEGELVSITPSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEI 126
++ EG++V+I +E P+S+ YI+KKM G KL+K EI I+ ++VD KL N EI
Sbjct: 64 QKVVKELGVKEGDIVTIKHAEKPKSLPYIRKKMDGNKLKKEEIFEIIDEMVDGKLTNIEI 123
Query: 127 SALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNIIVVPIV 186
SA VT++ +NG+DMDEI A+TI MAETG+M++ + I DVHSIGGVPGNK ++VVPIV
Sbjct: 124 SAFVTSLYINGMDMDEIEAMTIRMAETGEMVNWEGH-IFDVHSIGGVPGNKYALLVVPIV 182
Query: 187 AAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEKIGACLVWGGALNLAPA 246
A+AGL IPKTSSRAITSAAGTADVVEV T V L+++EIKR+V++ C+VWGGAL+LAPA
Sbjct: 183 ASAGLKIPKTSSRAITSAAGTADVVEVLTRVDLTIEEIKRVVKETNGCMVWGGALDLAPA 242
Query: 247 DDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDF 306
DD+TI+VER L +DP L+L+S+M+KK A+G +LIDIPTG GAKV++++EA SLA+ F
Sbjct: 243 DDITINVERPLGIDPEPLLLSSVMAKKLAMGVNKLLIDIPTGYGAKVKSIKEASSLARKF 302
Query: 307 IELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMT-GKGPGSLVEKALGLAGIL 365
IEL +L E AITYGGQPIG +GPALEAKEAL L + P SLVEK++ LAGIL
Sbjct: 303 IELSDRLRIVTECAITYGGQPIGRAIGPALEAKEALLALEDYTQAPTSLVEKSISLAGIL 362
Query: 366 LEMGGVAPRGMGKKVAREILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYTIHAQT 425
LEMGGVAP G GK++A ++L GKA++K EII QGG + ++I +G IH+
Sbjct: 363 LEMGGVAPTGEGKELAEDLLARGKAHDKFMEIIVAQGG-KEVSSDEIEVGKYKADIHSPI 421
Query: 426 SGYVTGIDNKAITAIAREAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKAI 485
GYVT I N IT IA+EAGAP DK AG+ L+VKVG KV++GD L+TI+++SE RL AI
Sbjct: 422 DGYVTRISNAGITKIAKEAGAPNDKKAGIYLNVKVGNKVEKGDVLYTIYSDSEERLKSAI 481
Query: 486 ILARRLEPIKIEGMVLQ 502
LAR L PIK+EGM+LQ
Sbjct: 482 KLARILYPIKVEGMLLQ 498
>gi|11498940 thymidine phosphorylase (deoA-2) [Archaeoglobus fulgidus]
>gi|7427934|pir||E69417 probable thymidine phosphorylase
(EC 2.4.2.4) 2 - Archaeoglobus fulgidus
>gi|2649232|gb|AAB89902.1| (AE001011) thymidine
phosphorylase (deoA-2) [Archaeoglobus fulgidus]
Length = 505
Score = 436 bits (1109), Expect = e-121
Identities = 231/499 (46%), Positives = 322/499 (64%), Gaps = 4/499 (0%)
Query: 5 MRAKVRILNIRSGHFDVFINPKDAQEWKLHPNDLVKIESGKRSIYGSVVIG-DFVESGEV 63
M+ +++ L +R+ V ++ DA E L P D VK+ +S V I +F+ SGE
Sbjct: 1 MKFRIKTLPLRTERIAVVLSQDDAAELGLLPGDRVKVSYDGKSFVAEVEISQEFISSGEA 60
Query: 64 GLSLDILDAYQFSEGELVSITPSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRKLRN 123
G+ + SE +V I P P+SV YI+KK+ G K + EI+ I+ I L +
Sbjct: 61 GVCTFTAETCSLSEECVVEIVPFARPKSVEYIRKKLNGAKYEREEIKDIIGSISSDVLSD 120
Query: 124 TEISALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNIIVV 183
EISA + A E+ G+ DEI + AM E G+ + +R ++D+HSIGG+PGN+ ++I V
Sbjct: 121 IEISAFILANEIVGMQNDEIQWMIEAMVEVGERVVFERGTVVDMHSIGGLPGNRFSLIAV 180
Query: 184 PIVAAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEKIGACLVWGGALNL 243
P VAAAGL IPKT+SRAIT+A+GTAD +EV NV LS+DEIK I E++G + W +
Sbjct: 181 PTVAAAGLLIPKTASRAITTASGTADTMEVLANVNLSVDEIKEITEEVGGVIAWNAPTGI 240
Query: 244 APADDLTIHVERRLSLDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLA 303
APAD+ I VE +L L P+ ++AS++SKK G++++ IDIP GK AKVE ++ R A
Sbjct: 241 APADEKIIRVEYQLELSPKPHLMASVLSKKLGSGARFVAIDIPVGKKAKVENVDVGRGFA 300
Query: 304 KDFIELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAG 363
+E+G+ L V A+T G QP+G +GPALEA+E LE +M K G L+EK+LG+AG
Sbjct: 301 NAMMEIGRNLNLKVATALTDGSQPLGRAIGPALEAREVLE-VMERKVEGDLLEKSLGIAG 359
Query: 364 ILLEMGGVAPRGMGKKVAREILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYTIHA 423
IL EM G+A G + AR+I ESGK EK +EI+ QGGD ++K ED+ +GDKTYT+HA
Sbjct: 360 ILFEMTGIATNGY--QHARKIFESGKTLEKFREIVAAQGGDESVKAEDVAVGDKTYTLHA 417
Query: 424 QTSGYVTGIDNKAITAIAREAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDK 483
GYV ID A+ IAR AGAP+DKGAGV +H K GE VK GDPL TI+AE E +LD
Sbjct: 418 AKEGYVREIDIAALNEIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDN 477
Query: 484 AIILARRLEPIKIEGMVLQ 502
AI +A + +I G++++
Sbjct: 478 AIEVANTKQAFEISGVIIE 496
>pdb|1BRW|B Chain B, The Crystal Structure Of Pyrimidine Nucleoside
Phosphorylase In A Closed Conformation
>gi|6729724|pdb|1BRW|A Chain A, The Crystal Structure Of
Pyrimidine Nucleoside Phosphorylase In A Closed
Conformation
Length = 433
Score = 215 bits (543), Expect = 7e-55
Identities = 149/419 (35%), Positives = 228/419 (53%), Gaps = 20/419 (4%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
V I KK G+ L K EIE IVR + + + ++SAL AI G+ +E AALT+AM
Sbjct: 4 VDLIAKKRDGKALTKEEIEWIVRGYTNGDIPDYQMSALAMAIYFRGMTEEETAALTMAMV 63
Query: 152 ETGDMLDID--RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTAD 209
++G+MLD+ R +D HS GGV G+ T +++ P+VA+ G+ + K S R + GT D
Sbjct: 64 QSGEMLDLSSIRGVKVDKHSTGGV-GDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTID 122
Query: 210 VVEVFT--NVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHV-ERRLSLDPRGLML 266
+E +V +S DE R+V + G ++ G +L PAD + + +++ L+
Sbjct: 123 KLESVPGFHVEISKDEFIRLVNENGIAII-GQTGDLTPADKKLYALRDVTATVNSIPLIA 181
Query: 267 ASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQ 326
+SIMSKK A G+ I++D+ TG GA ++ ++EAR LA+ +++GK++G+ I+ Q
Sbjct: 182 SSIMSKKIAAGADAIVLDVKTGAGAFMKKLDEARRLARVMVDIGKRVGRRTMAVISDMSQ 241
Query: 327 PIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPR-GMGKKVAREIL 385
P+GY VG ALE KEA+ETL G GP L E L L ++ + AP +++ E +
Sbjct: 242 PLGYAVGNALEVKEAIETL-KGNGPHDLTELCLTLGSHMVYLAEKAPSLDEARRLLEEAI 300
Query: 386 ESGKAYEKIKEIIEEQGGDPNIKP--EDIPIGDKTYTIHAQTSGYVTGIDNKAITAIARE 443
SG A K + QGGD ++ + +P T T+ A GYV + I A
Sbjct: 301 RSGAAIAAFKTFLAAQGGDASVVDDLDKLPKAAYTSTVTAAADGYVAEMAADDIGTAAMW 360
Query: 444 AGAPE-------DKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLD--KAIILARRLEP 493
GA D G+ LH K+G++V++G+ L TIH+ LD + I A RL P
Sbjct: 361 LGAGRAKKEDVIDLAVGIVLHKKIGDRVQKGEALATIHSNRPDVLDVKEKIEAAIRLSP 419
>pir||B72228 pyrimidine-nucleoside phosphorylase - Thermotoga maritima (strain
MSB8) >gi|4982227|gb|AAD36720.1|AE001807_11 (AE001807)
pyrimidine-nucleoside phosphorylase [Thermotoga
maritima]
Length = 434
Score = 203 bits (512), Expect = 3e-51
Identities = 134/410 (32%), Positives = 223/410 (53%), Gaps = 18/410 (4%)
Query: 95 IKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETG 154
I KK GEKL + EIE +V V ++ + +++A + A+ LD +E T M +G
Sbjct: 7 ILKKRNGEKLSREEIEFMVGGYVKGEIPDYQMAAFLMAVYFRHLDEEETYYFTETMMRSG 66
Query: 155 DMLDIDRKP--IMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADVVE 212
++LD+ P +D HS GGV G+KT ++V P+VA+AG+ + K S RA+ GT D +E
Sbjct: 67 EVLDLSEIPGTKVDKHSTGGV-GDKTTLVVAPLVASAGVPVAKMSGRALGHTGGTIDKLE 125
Query: 213 VFTN--VTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHV-ERRLSLDPRGLMLASI 269
LSL+E + V+K G +V G NL PAD + + ++D L+ +SI
Sbjct: 126 SIPGFRTELSLEEFIKNVKKYGIAIV-GQTGNLVPADKKIYALRDATATVDEISLIASSI 184
Query: 270 MSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQPIG 329
MSKK A GS ++D+ G GA ++ E+A+ LA + + ++ G+ ++ QP+G
Sbjct: 185 MSKKLAGGSDAFVLDVKFGTGAFMKGFEDAKKLAFLMLRIAQQHGKKAVAVLSNMDQPLG 244
Query: 330 YTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPRGMGKKVAREILESGK 389
VG +LE EA+ETL G GP L E +L L ++LE+ GVA GKK+ +E LE+G+
Sbjct: 245 KAVGNSLEVIEAIETL-KGNGPEDLKELSLTLGALMLELAGVADFEEGKKILQEKLETGE 303
Query: 390 AYEKIKEIIEEQGGDPNIKPED---IPIGDKTYTIHAQTSGYVTGIDNKAITAIAREAGA 446
A +K + +++ QGG+ + + +P+ ++ A G+V+ ID + + + GA
Sbjct: 304 ALDKFRLLVKAQGGNERVVDDPWRVLPVAEQVVEFSAAREGFVSKIDAEKVGIASMMLGA 363
Query: 447 PE-------DKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKAIILAR 489
D G+ + K+G+ VK+G+ + + S ++ A+ L +
Sbjct: 364 GRKKKEDRIDHSVGIIVEKKLGDSVKKGEAIARLFVSDRSDVESALKLLK 413
>sp|O53366|DEOA_MYCTU THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|7433924|pir||A70843 probable
thymidine phosporylase - Mycobacterium tuberculosis
(strain H37RV) >gi|2894224|emb|CAA17086.1| (AL021841)
deoA [Mycobacterium tuberculosis]
Length = 427
Score = 201 bits (507), Expect = 1e-50
Identities = 144/404 (35%), Positives = 216/404 (52%), Gaps = 28/404 (6%)
Query: 95 IKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETG 154
I+ K G +L I+ +V+ D ++ + ++SAL+ AI G+D EIA T AM +G
Sbjct: 12 IRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASG 71
Query: 155 DMLDIDRKPI--MDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADVVE 212
LD P+ +D HS GGV G+K + +VP+VAA G +P+ S R + GT D +E
Sbjct: 72 ARLDFTDLPLATVDKHSTGGV-GDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLE 130
Query: 213 VFTNVTLSLDEIKRIVEK---IGACLVWGGALNLAPADDLTIHVERRLS--LDPRGLMLA 267
T T +L +R+ E+ +GA + G LAPAD ++ R ++ ++ L+ +
Sbjct: 131 SITGFTANLSN-QRVREQLCDVGAAIFAAG--QLAPAD-AKLYALRDITGTVESLPLIAS 186
Query: 268 SIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQP 327
SIMSKK A G+ +++D+ G GA + + +AR LA +ELG G +T P
Sbjct: 187 SIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALLTEMNCP 246
Query: 328 IGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPRGMGKKVAREILES 387
+G TVG ALE EALE L G GP +VE L LAG +LE+ G+ R + L
Sbjct: 247 LGRTVGNALEVAEALEVL-AGGGPPDVVELTLRLAGEMLELAGIHGRD-----PAQTLRD 300
Query: 388 GKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYTIHAQTSGYVTGIDNKAITAIAREAGAP 447
G A ++ + ++ QGGD + KP +PIG + T+ A SG + ID A+ A GA
Sbjct: 301 GTAMDRFRRLVAAQGGDLS-KP--LPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAG 357
Query: 448 EDK-------GAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKA 484
+ GAGV++H + GE V G+PLFT++ + R A
Sbjct: 358 RSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAA 401
>dbj|BAB05252.1| (AP001512) pyrimidine-nucleoside phosphorylase [Bacillus
halodurans]
Length = 433
Score = 192 bits (483), Expect = 7e-48
Identities = 133/402 (33%), Positives = 209/402 (51%), Gaps = 18/402 (4%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
V I+KK G L K EI+ I+ + + + ++SA AI + DE A LT+AMA
Sbjct: 4 VDLIEKKRDGLALTKEEIDFIISGYTNGDIPDYQMSAFAMAIFFQDMTADERAYLTMAMA 63
Query: 152 ETGDMLDID--RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTAD 209
E+GD +D+ +D HS GGV G+KT I + P+VA+ G+ + K S R + GT D
Sbjct: 64 ESGDQIDLSGIEGVKVDKHSTGGV-GDKTTIALAPLVASVGVPVAKMSGRGLGHTGGTID 122
Query: 210 VVEVFT--NVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHV-ERRLSLDPRGLML 266
+E NV + + +V K +V G NL PAD + + +++ L+
Sbjct: 123 KLESIAGFNVEIPTERFLELVNKNKLAVV-GQTANLTPADKKLYGLRDVTATVNSIPLIA 181
Query: 267 ASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQ 326
+SIMSKK A G+ I++D+ TG GA ++ +E+++ LA+ +E+G LG+ I+ Q
Sbjct: 182 SSIMSKKIASGANAIVLDVKTGSGAFMKELEQSKELAEAMVEIGNNLGRQTMAVISDMNQ 241
Query: 327 PIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPR-GMGKKVAREIL 385
P+G+ VG ALE KEA++ ++ G+GP L E L L ++ + A ++ E +
Sbjct: 242 PLGWAVGNALEVKEAID-MLRGEGPDDLRELCLTLGSHMVFLAKQATSVADARQKLEEAI 300
Query: 386 ESGKAYEKIKEIIEEQGGDPNI--KPEDIPIGDKTYTIHAQTSGYVTGIDNKAITAIARE 443
SGKA + +K I Q GDP++ P+ +P + A+ +G+V I I A
Sbjct: 301 SSGKALDTLKTFISAQNGDPSVVDNPQLLPTAQFQIEVKAEENGHVASIVADRIGTAAMV 360
Query: 444 AGAPE-------DKGAGVKLHVKVGEKVKEGDPLFTIHAESE 478
GA D G+ L K+GE V+ G+ L +HA E
Sbjct: 361 LGAGRATKESDIDLSVGIVLKKKMGESVQAGETLAILHANKE 402
>sp|P77836|PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) >gi|2126872|pir||JT0875
pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) -
Bacillus stearothermophilus >gi|2126873|pir||JC4992
pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) -
Bacillus stearothermophilus >gi|1620901|dbj|BAA13512.1|
(D87961) Pyrimidine nucleoside phosphorylase [Bacillus
stearothermophilus]
Length = 433
Score = 189 bits (474), Expect = 8e-47
Identities = 135/405 (33%), Positives = 214/405 (52%), Gaps = 24/405 (5%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
V I+KK G L K EI+ I+ + + ++SAL AI G++ +E A LT+AM
Sbjct: 4 VDLIEKKRDGHALTKEEIQFIIEGYTKGDIPDYQMSALAMAIFFRGMNEEETAELTMAMV 63
Query: 152 ETGDMLDIDRKP--IMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTAD 209
+GD +D+ R +D HS GGV G+ T +++ P+VA+ G+ + K S R + GT D
Sbjct: 64 HSGDTIDLSRIEGIKVDKHSTGGV-GDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTID 122
Query: 210 VVEVFT--NVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHV-ERRLSLDPRGLML 266
+E +V ++ DE +V K +V G + NL PAD + + +++ L+
Sbjct: 123 KLESVPGFHVEITNDEFIDLVNKNKIAVV-GQSGNLTPADKKLYALRDVTATVNSIPLIA 181
Query: 267 ASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQ 326
+SIMSKK A G+ I++D+ TG GA ++ + +A++LAK +++G ++G+ I+ Q
Sbjct: 182 SSIMSKKIAAGADAIVLDVKTGVGAFMKDLNDAKALAKAMVDIGNRVGRKTMAIISDMSQ 241
Query: 327 PIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPRGMGKKVAREILE 386
P+GY +G ALE KEA++TL G+GP E L L M +A + + AR +LE
Sbjct: 242 PLGYAIGNALEVKEAIDTL-KGEGPEDFQELCLVLGS---HMVYLAEKASSLEEARHMLE 297
Query: 387 ----SGKAYEKIKEIIEEQGGDPNI--KPEDIPIGDKTYTIHAQTSGYVTGIDNKAITAI 440
G A + K + QGGD ++ P +P + A+ GYV+ I A+
Sbjct: 298 KAMKDGSALQTFKTFLAAQGGDASVVDDPSKLPQAKYIIELEAKEDGYVSEIVADAVGTA 357
Query: 441 AREAGAPE-------DKGAGVKLHVKVGEKVKEGDPLFTIHAESE 478
A GA D G+ L KVG+ VK+G+ L TI++ E
Sbjct: 358 AMWLGAGRATKESTIDLAVGLVLRKKVGDAVKKGESLVTIYSNRE 402
>pir||A75520 pyrimidine-nucleoside phosphorylase - Deinococcus radiodurans
(strain R1) >gi|6458125|gb|AAF10021.1|AE001903_9
(AE001903) pyrimidine-nucleoside phosphorylase
[Deinococcus radiodurans]
Length = 478
Score = 187 bits (470), Expect = 2e-46
Identities = 141/443 (31%), Positives = 221/443 (49%), Gaps = 19/443 (4%)
Query: 61 GEVGLSLDILDAYQFSEGELVSITPSETPESVR-YIKKKMRGEKLRKVEIETIVRDIVDR 119
G +G L ++ + + P P +V I KK G E+E +V
Sbjct: 20 GVIGRPLSVMPVLWHTRA-MTHTAPLSPPLAVPDLIAKKRDGGAHTHAELEALVLGFTRG 78
Query: 120 KLRNTEISALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKP-IMDVHSIGGVPGNKT 178
++ + ++SA + A+ + G+ E A LT+ MA +G+ LD+ P +D HS GGV G+KT
Sbjct: 79 EVPDYQLSAWLMAVFLRGMTPQETADLTLVMAASGEQLDLGALPDTVDKHSTGGV-GDKT 137
Query: 179 NIIVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIKRIVEK--IGACLV 236
++++ P++AA GLT+ K S R + GT D +E T L E + + + IG LV
Sbjct: 138 SLVLTPMLAALGLTVAKMSGRGLAHTGGTIDKLESIPGWTPELPEDRFLAQARDIGLALV 197
Query: 237 WGGALNLAPADDLTIHVERRLSLDP-RGLMLASIMSKKYAIGSQYILIDIPTGKGAKVET 295
G + +LAPAD + + P L+ +SIMSKK A G++ I++D+ G GA + T
Sbjct: 198 -GQSKDLAPADGKLYALRDVTATVPCLPLIASSIMSKKLASGARTIVLDVKVGAGAFMTT 256
Query: 296 MEEARSLAKDFIELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLV 355
E R LA+ +++G + G+ V +T P+G+ G +LE +EAL TL G GP L
Sbjct: 257 PEAGRELAQAMVDIGTRAGRRVRAVLTEMDTPLGHLAGNSLEVQEALATL-RGAGPSDLT 315
Query: 356 EKALGLAGILLEMGGVAPRGMGKKVAREILESGKAYEKIKEIIEEQGGDPNI--KPEDIP 413
+ + LA L G G + AR+ L G A K + + QGGDP+ PE +
Sbjct: 316 DLCVALAVEALVAHG-EDAGQAEARARQTLHDGSALAKFRAFVAAQGGDPSYVDDPERLD 374
Query: 414 IGDKTYTIHAQTSGYVTGID----NKAITAIA---REAGAPEDKGAGVKLHVKVGEKVKE 466
+ + A SG+VT +D +A+ A+ G D G GV+L K GE V
Sbjct: 375 VAPGRAEMLAAQSGFVTRVDALSVGRAVLALGGGRERKGEAIDHGVGVELLKKPGEAVGA 434
Query: 467 GDPLFTIHAESESRLDKAIILAR 489
G+ + ++ L++A L R
Sbjct: 435 GEAVLRLYHRGGRGLERAQALLR 457
>sp|P39142|PDP_BACSU PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) >gi|1075897|pir||S49457
pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) pdp -
Bacillus subtilis >gi|558559|emb|CAA57664.1| (X82174)
pyrimidine nucleoside phosphorylase [Bacillus subtilis]
>gi|1408508|dbj|BAA08339.1| (D45912) pyrimidine
nucleoside phosphorylase [Bacillus subtilis]
>gi|2636486|emb|CAB15976.1| (Z99124)
pyrimidine-nucleoside phosphorylase [Bacillus subtilis]
Length = 434
Score = 182 bits (457), Expect = 8e-45
Identities = 132/404 (32%), Positives = 212/404 (51%), Gaps = 19/404 (4%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
V I KK G++L EI+ V D + + + SAL AI + E A LT+AM
Sbjct: 4 VDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMAIFFQDMSDRERADLTMAMV 63
Query: 152 ETGDMLDIDRKP--IMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTAD 209
+G+ +D+ +D HS GGV + P+VAA + + K S R + GT D
Sbjct: 64 NSGETIDLSAIEGIKVDKHSTGGVWRHDNARSSSPLVAALDVPVAKMSGRGLGHTGGTID 123
Query: 210 VVEVFT--NVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHVERRLS--LDPRGLM 265
+E +V L+ DE ++V + ++ G + NL PAD ++ R ++ ++ L+
Sbjct: 124 KLEAIMGFHVELTKDEFIKLVNRDKVAVI-GQSGNLTPADK-KLYALRDVTGTVNSIPLI 181
Query: 266 LASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGG 325
+SIMSKK A G+ I++D+ TG GA ++T E+A LAK + +G +G+ I+
Sbjct: 182 ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELAKAMVRIGNNVGRQTMAVISDMS 241
Query: 326 QPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPR-GMGKKVAREI 384
QP+G+ +G ALE KEA++TL G+GP L E L L ++ + A + E+
Sbjct: 242 QPLGFAIGNALEVKEAIDTL-KGEGPEDLHELVLTLGSQMVVLAKKADTLDEARAKLEEV 300
Query: 385 LESGKAYEKIKEIIEEQGGDPNI--KPEDIPIGDKTYTIHAQTSGYVTGI--DNKAITAI 440
+++GKA EK K+ ++ QGGD +I P +P + A+ +G V+ I D + A+
Sbjct: 301 MKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAYQIDVPAKEAGVVSEIVADEIGVAAM 360
Query: 441 AREAGAPE-----DKGAGVKLHVKVGEKVKEGDPLFTIHAESES 479
AG D G+ L KVG+KV++G+PL T++A E+
Sbjct: 361 LLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGEPLVTLYANREN 404
>gb|AAD17954.1| (AF105341) pyrimidine nucleoside phosphorylase [Listeria
monocytogenes]
Length = 419
Score = 181 bits (454), Expect = 2e-44
Identities = 138/407 (33%), Positives = 215/407 (51%), Gaps = 27/407 (6%)
Query: 108 EIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETGDMLDIDRKP--IM 165
EI+ + + ++ + + SAL AI ++ E A LT+AM +GD +D+ +
Sbjct: 6 EIQFFIDGYTNGEIPDYQASALAMAIFFQDMNDQERADLTMAMVGSGDTIDLSEIEGIKV 65
Query: 166 DVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVFTNVTLSLDEIK 225
D HS GGV G+ T +++ P+VAA G+ + K S R + GT D +E + LD+ K
Sbjct: 66 DKHSTGGV-GDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGTIDKLESIEGFHIELDK-K 123
Query: 226 RIVEKIGA--CLVWGGALNLAPADDLTIHVERRLS--LDPRGLMLASIMSKKYAIGSQYI 281
++ + V G + NL PAD ++ R ++ ++ L+ +SIMSKK A G+ I
Sbjct: 124 DFIDLVNRDKVAVIGQSGNLTPADK-KMYALRDVTGIVNSIPLIASSIMSKKIAAGADAI 182
Query: 282 LIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQPIGYTVGPALEAKEA 341
++D+ TG GA ++T E+A +LA + +G +G+ I+ QP+G +G ALE KEA
Sbjct: 183 VLDVKTGAGAFMKTDEDAENLAHAMVRIGNNVGRNTMAVISDMSQPLGEAIGNALEVKEA 242
Query: 342 LETLMTGKGPGSLVEKALGLAG---ILLEMGGVAPRGMGKKVAREILESGKAYEKIKEII 398
++TL G+GP L E L L +L + K + E++E+G A EK K +
Sbjct: 243 IDTL-KGQGPEDLTELVLVLGSQMVVLAKQAETLDEARAKLI--EVIENGAALEKFKTFL 299
Query: 399 EEQGGDPNI--KPEDIPIGDKTYTIHAQTSGYVTGI--DNKAITAIAREAG--APEDK-- 450
QGGD +I PE +P + A+TSG+V+ I D I A+ AG ED+
Sbjct: 300 SNQGGDASIVDHPEKLPQAKYQIEVPAKTSGFVSQIVADEIGIAAMILGAGRATKEDEIN 359
Query: 451 -GAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKAIILARRLEPIKI 496
G+ L KVG+ VKEG+ L TI A+ E D + A+ E I+I
Sbjct: 360 LAVGLMLRKKVGDAVKEGESLVTIFADQE---DVENVKAKIYENIQI 403
>sp|P19971|TYPH_HUMAN THYMIDINE PHOSPHORYLASE PRECURSOR (TDRPASE) (TP) (PLATELET-DERIVED
ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN)
>gi|87362|pir||S03904 platelet-derived endothelial cell
growth factor precursor - human >gi|226324|prf||1506442A
endothelial cell growth factor [Homo sapiens]
Length = 482
Score = 176 bits (442), Expect = 5e-43
Identities = 131/439 (29%), Positives = 221/439 (49%), Gaps = 40/439 (9%)
Query: 85 PSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIA 144
P + PE +R K G +L + +I V +V+ + +I A++ AI + G+D++E +
Sbjct: 33 PKQLPELIRM---KRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETS 89
Query: 145 ALTIAMAETGDMLDID---RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAI 201
LT A+A++G L+ R+ ++D HS GGV G+K ++++ P +AA G +P S R +
Sbjct: 90 VLTQALAQSGQQLEWPEAWRQQLVDKHSTGGV-GDKVSLVLAPALAACGCKVPMISGRGL 148
Query: 202 TSAAGTADVVEVFT--NVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHVERRLS- 258
GT D +E NV S ++++ ++++ G C+V G + L PAD + ++ R ++
Sbjct: 149 GHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIV-GQSEQLVPADGI-LYAARDVTA 206
Query: 259 -LDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYV 317
+D L+ ASI+SKK G +++D+ G A E+AR LAK + +G LG V
Sbjct: 207 TVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRV 266
Query: 318 EVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVA-PRGM 376
A+T +P+G VG ALE +EAL M G GP L + L G LL + G A +
Sbjct: 267 AAALTAMDKPLGRCVGHALEVEEAL-LCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQ 325
Query: 377 GKKVAREILESGKAYEKIKEIIEEQGGDPNI-----------KPEDIPIGDKTYTIHAQT 425
G L+ G A + + ++ QG DP + + + +P + + A
Sbjct: 326 GAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPA 385
Query: 426 SGYVTGIDNKAITAIARE-------AGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAES- 477
G V + + + E AG P G G +L V VG++++ G P +H +
Sbjct: 386 DGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGP 445
Query: 478 -----ESR-LDKAIILARR 490
+SR L +A++L+ R
Sbjct: 446 ALSGPQSRALQEALVLSDR 464
>gi|4503445 endothelial cell growth factor 1 (platelet-derived) [Homo sapiens]
>gi|189701|gb|AAA60043.1| (M63193) endothelial cell
growth factor [Homo sapiens] >gi|6862560|gb|AAB03344.2|
(U62317) endothelial cell growth factor 1 [Homo sapiens]
Length = 482
Score = 176 bits (442), Expect = 5e-43
Identities = 131/439 (29%), Positives = 221/439 (49%), Gaps = 40/439 (9%)
Query: 85 PSETPESVRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIA 144
P + PE +R K G +L + +I V +V+ + +I A++ AI + G+D++E +
Sbjct: 33 PKQLPELIRM---KRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETS 89
Query: 145 ALTIAMAETGDMLDID---RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAI 201
LT A+A++G L+ R+ ++D HS GGV G+K ++++ P +AA G +P S R +
Sbjct: 90 VLTQALAQSGQQLEWPEAWRQQLVDKHSTGGV-GDKVSLVLAPALAACGCKVPMISGRGL 148
Query: 202 TSAAGTADVVEVFT--NVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHVERRLS- 258
GT D +E NV S ++++ ++++ G C+V G + L PAD + ++ R ++
Sbjct: 149 GHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIV-GQSEQLVPADGI-LYAARDVTA 206
Query: 259 -LDPRGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYV 317
+D L+ ASI+SKK G +++D+ G A E+AR LAK + +G LG V
Sbjct: 207 TVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRV 266
Query: 318 EVAITYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVA-PRGM 376
A+T +P+G VG ALE +EAL M G GP L + L G LL + G A +
Sbjct: 267 AAALTAMDKPLGRCVGHALEVEEAL-LCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQ 325
Query: 377 GKKVAREILESGKAYEKIKEIIEEQGGDPNI-----------KPEDIPIGDKTYTIHAQT 425
G L+ G A + + ++ QG DP + + + +P + + A
Sbjct: 326 GAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPA 385
Query: 426 SGYVTGIDNKAITAIARE-------AGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAES- 477
G V + + + E AG P G G +L V VG++++ G P +H +
Sbjct: 386 DGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGP 445
Query: 478 -----ESR-LDKAIILARR 490
+SR L +A++L+ R
Sbjct: 446 ALSGPQSRALQEALVLSDR 464
>sp|P47717|TYPH_MYCPI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|1086261|pir||C53312 thymidine
phosphorylase (EC 2.4.2.4) - Mycoplasma pirum (strain
BER) >gi|401784|gb|AAA25432.1| (L13289) thymidine
phosphorylase [Mycoplasma pirum]
Length = 419
Score = 147 bits (368), Expect = 2e-34
Identities = 122/407 (29%), Positives = 205/407 (49%), Gaps = 19/407 (4%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
+ I+ K +KL + +I + +V++ + + +ISAL+ AI NGLD +E+ LT AM
Sbjct: 4 IEIIELKKNKKKLSQDQINFCISGLVNKSIPDYQISALLMAIWFNGLDDNELYFLTKAMI 63
Query: 152 ETGDMLDID---RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTA 208
++G + +K ++D HS GG+ G+K +I + PI+ + L + K S R + GT
Sbjct: 64 DSGKIYKFHPEYKKILIDKHSTGGI-GDKVSIALRPILVSFDLGVAKLSGRGLGFTGGTI 122
Query: 209 DVVE-VFTNVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHVERRLS--LDPRGLM 265
D +E + N + L K+I+ I + G ++ PAD L ++ R ++ +D L+
Sbjct: 123 DKLESINVNTDIDLKNSKKILN-IANMFIVGQTNDIVPADKL-LYALRDVTGTVDSLPLI 180
Query: 266 LASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGG 325
ASI+SKK+A+ S YI IDI G+GA +E A+ ++ L KK + V ++
Sbjct: 181 AASILSKKFALESDYIFIDIKYGQGAFCHDIETAKKISNIMKNLAKKFKRKVYFVLSDMN 240
Query: 326 QPIGYTVGPALEAKEALETLMTGKGPGSLVEKALG--LAGILLEMGGVAPRGMGKKVARE 383
+ +G TVG A+E KEA++ L G+ +K + + ILL+ + K+
Sbjct: 241 EVLGNTVGNAIEVKEAIDFLKNNSDVGTYFKKLMFDLVTLILLKTKKCKTKKEAKEKINY 300
Query: 384 ILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTYT-IHAQTSGYVTGIDNKAITAIAR 442
+LE+ A+ IE Q G+ D K +T I A SG ++ + I
Sbjct: 301 VLENKIAFNNFCNWIELQNGNIAKIKNDTFFKPKYWTNIAAWKSGKISYKSIIELAEIGV 360
Query: 443 EAGA----PEDK---GAGVKLHVKVGEKVKEGDPLFTIHAESESRLD 482
+ G+ EDK AG+ LH K EK+K D + T+++ + D
Sbjct: 361 DLGSGRRKKEDKIDFQAGIYLHAKSNEKIKIKDKILTLYSSKPIKQD 407
>pir||E82087 thymidine phosphorylase VC2349 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9656917|gb|AAF95492.1| (AE004305)
thymidine phosphorylase [Vibrio cholerae]
Length = 475
Score = 146 bits (365), Expect = 5e-34
Identities = 114/414 (27%), Positives = 199/414 (47%), Gaps = 32/414 (7%)
Query: 95 IKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETG 154
I++K GE L EI ++ + + + +I+A AI + M E ALT AM ++G
Sbjct: 41 IRRKRDGEVLTNDEINFFIQGVANNTVSEGQIAAFAMAIFFREMTMPERIALTCAMRDSG 100
Query: 155 DMLDIDRK----PIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADV 210
++D PI+D HS GGV G+ T++++ P+VAA G +P S R + GT D
Sbjct: 101 MVIDWSHMNFDGPIVDKHSTGGV-GDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDK 159
Query: 211 VEVFT--NVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHVERRLS--LDPRGLML 266
+E N+T + D ++ ++ G ++ G +LAPAD ++ R ++ +D L+
Sbjct: 160 LEAIPGYNITPTNDVFGKVTKQAGVAII-GQTGDLAPADK-RVYATRDITATVDNISLIT 217
Query: 267 ASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQ 326
ASI+SKK A G + +++D+ G GA + T E + LAK + + G +T Q
Sbjct: 218 ASILSKKLAAGLESLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTNTTAILTDMNQ 277
Query: 327 PIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVA-PRGMGKKVAREIL 385
+ + G A+E +EA+ L L+E + +L +G +A ++ + +L
Sbjct: 278 VLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMASCAEMLVLGKLAKDTAQAREKLQAVL 337
Query: 386 ESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTY--------TIHAQTSGYVTGIDNKAI 437
++G+A ++ +++ GG P D Y ++AQ SG ++ +D +AI
Sbjct: 338 DNGQAADRFGKMVAGLGG-----PSDFVENYDKYLAKAEIIRPVYAQQSGVISAMDTRAI 392
Query: 438 -TAIAREAGAPE------DKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKA 484
A+ G D G +++GE PL IHA +E + +A
Sbjct: 393 GMAVVGMGGGRRVATDRIDYAVGFDQFIRLGEIADSNKPLAMIHARNEEQWQQA 446
>sp|P47297|TYPH_MYCGE THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|1361865|pir||F64205 thymidine
phosphorylase (EC 2.4.2.4) - Mycoplasma genitalium
>gi|1045724|gb|AAC71267.1| (U39684) thymidine
phosphorylase (deoA) [Mycoplasma genitalium]
Length = 421
Score = 144 bits (360), Expect = 2e-33
Identities = 112/401 (27%), Positives = 193/401 (47%), Gaps = 16/401 (3%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
+ I KK RG+ L EI V ++++ + + +I+A + AI G++ +E+ LT AM
Sbjct: 4 INLINKKQRGKALNLAEINWFVNAVLNKTIADYQITAFLMAIWFKGMNPNELFLLTKAMV 63
Query: 152 ETGDMLDIDR--KPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTAD 209
+TG+++ + K +D HS GG+ G+K ++ +VPI+ + G ++ K S R + GT D
Sbjct: 64 DTGEIIKFNHHGKISVDKHSTGGI-GDKVSLALVPILTSLGFSVAKLSGRGLGYTGGTID 122
Query: 210 VVEVFTNVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHVERRL-SLDPRGLMLAS 268
+E T D+ + C + G + ++AP D + + ++D L+ +S
Sbjct: 123 KLEAVGVKTELTDQQAQACLDKNDCFIIGQSKDIAPVDKVLYGLRDITGTVDSLPLIASS 182
Query: 269 IMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQPI 328
IMSKK A+ ++YI ID+ GKGA +T + A LAK + K + + V ++ Q +
Sbjct: 183 IMSKKLAVMNEYIFIDLKYGKGAFCKTKKIANELAKLMQSIAKSFKRKLSVKLSDMNQVL 242
Query: 329 GYTVGPALEAKEALETL---MTGKGPGSLVEKALGLAGILLEMGGVAPRGMGKKVAREIL 385
G VG +E EA+ L + G + + ILLE + ++ +++L
Sbjct: 243 GKAVGNVIEVNEAVNFLKQDLDQVGQDFIDLMQTIVINILLETKQAKTKQKAIELYQDVL 302
Query: 386 ESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTY--TIHAQTSGYVTGIDNKAITAIARE 443
S KA+ + IE QGG+ + + Y +I A+ SG + D + I
Sbjct: 303 TSKKAWNRFLSFIESQGGNVELFTQKEGFFKPKYKASIKAEKSGILHFTDPIDLAKIGIN 362
Query: 444 AGAPE-------DKGAGVKLHVKVGEKVKEGDPLFTIHAES 477
GA D AG+ L K E V GD + +++ S
Sbjct: 363 LGAGRMKKTDQIDPMAGLFLMKKDNESVAVGDTVLNLYSSS 403
>pdb|2TPT| Structural And Theoretical Studies Suggest Domain Movement
Produces An Active Conformation Of Thymidine
Phosphorylase >gi|4139737|pdb|1OTP| Structural And
Theoretical Studies Suggest Domain Movement Produces An
Active Conformation Of Thymidine Phosphorylase
>gi|4389347|pdb|1AZY|A Chain A, Structural And
Theoretical Studies Suggest Domain Movement Produces An
Active Conformation Of Thymidine Phosphorylase
>gi|4389348|pdb|1AZY|B Chain B, Structural And
Theoretical Studies Suggest Domain Movement Produces An
Active Conformation Of Thymidine Phosphorylase
>gi|230379|pdb|1TPT| Thymidine Phosphorylase
(E.C.2.4.2.4)
Length = 440
Score = 142 bits (354), Expect = 1e-32
Identities = 114/409 (27%), Positives = 197/409 (47%), Gaps = 22/409 (5%)
Query: 95 IKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETG 154
I+KK G L EI + I D + +I+AL I + + M E +LT+AM ++G
Sbjct: 8 IRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSG 67
Query: 155 DMLDID----RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADV 210
+LD PI+D HS GGV G+ T++++ P+VAA G IP S R + GT D
Sbjct: 68 TVLDWKSLHLNGPIVDKHSTGGV-GDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDK 126
Query: 211 VEVFTNVTLSLDE--IKRIVEKIGACLVWGGALNLAPADDLTIHVERRLS--LDPRGLML 266
+E + D+ + I++ +G ++ G +LAPAD + R ++ +D L+
Sbjct: 127 LESIPGFDIFPDDNRFREIIKDVGVAII-GQTSSLAPADK-RFYATRDITATVDSIPLIT 184
Query: 267 ASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQ 326
ASI++KK A G +++D+ G GA + T E + +LA+ + + G +T Q
Sbjct: 185 ASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQ 244
Query: 327 PIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVA-PRGMGKKVAREIL 385
+ + G A+E +EA++ L L + + L +L G +A + + +L
Sbjct: 245 VLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVL 304
Query: 386 ESGKAYEKIKEIIEEQGGDPNI---KPEDIPIGDKTYTIHAQTSGYVTGIDNKAITAIA- 441
++GKA E ++ Q G + + +P T ++A T G+V+ +D +A+
Sbjct: 305 DNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVV 364
Query: 442 ------REAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKA 484
R+A D G ++G++V PL IHA+ E+ +A
Sbjct: 365 AMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEA 413
>sp|P07650|TYPH_ECOLI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|1361254|pir||S56606 thymidine
phosphorylase (EC 2.4.2.4) deoA [validated] -
Escherichia coli >gi|537222|gb|AAA97278.1| (U14003)
thymidine phosphorylase [Escherichia coli]
>gi|1790842|gb|AAC77335.1| (AE000508) thymidine
phosphorylase [Escherichia coli K12]
Length = 440
Score = 142 bits (354), Expect = 1e-32
Identities = 114/409 (27%), Positives = 197/409 (47%), Gaps = 22/409 (5%)
Query: 95 IKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETG 154
I+KK G L EI + I D + +I+AL I + + M E +LT+AM ++G
Sbjct: 8 IRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSG 67
Query: 155 DMLDID----RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADV 210
+LD PI+D HS GGV G+ T++++ P+VAA G IP S R + GT D
Sbjct: 68 TVLDWKSLHLNGPIVDKHSTGGV-GDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDK 126
Query: 211 VEVFTNVTLSLDE--IKRIVEKIGACLVWGGALNLAPADDLTIHVERRLS--LDPRGLML 266
+E + D+ + I++ +G ++ G +LAPAD + R ++ +D L+
Sbjct: 127 LESIPGFDIFPDDNRFREIIKDVGVAII-GQTSSLAPADK-RFYATRDITATVDSIPLIT 184
Query: 267 ASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQ 326
ASI++KK A G +++D+ G GA + T E + +LA+ + + G +T Q
Sbjct: 185 ASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQ 244
Query: 327 PIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVA-PRGMGKKVAREIL 385
+ + G A+E +EA++ L L + + L +L G +A + + +L
Sbjct: 245 VLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVL 304
Query: 386 ESGKAYEKIKEIIEEQGGDPNI---KPEDIPIGDKTYTIHAQTSGYVTGIDNKAITAIA- 441
++GKA E ++ Q G + + +P T ++A T G+V+ +D +A+
Sbjct: 305 DNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVV 364
Query: 442 ------REAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKA 484
R+A D G ++G++V PL IHA+ E+ +A
Sbjct: 365 AMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEA 413
>pir||A37131 thymidine phosphorylase (EC 2.4.2.4) - Escherichia coli
Length = 441
Score = 140 bits (349), Expect = 4e-32
Identities = 114/410 (27%), Positives = 196/410 (47%), Gaps = 23/410 (5%)
Query: 95 IKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETG 154
I+KK G L EI + I D + +I+AL I + + M E +LT+AM ++G
Sbjct: 8 IRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSG 67
Query: 155 DMLDID----RKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADV 210
+LD PI+D HS GGV G+ T++++ P+VAA G IP S R + GT D
Sbjct: 68 TVLDWKSLHLNGPIVDKHSTGGV-GDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDK 126
Query: 211 VEVFTNVTLSLDEIKR---IVEKIGACLVWGGALNLAPADDLTIHVERRLS--LDPRGLM 265
+E + + R I++ +G ++ G +LAPAD + R ++ +D L+
Sbjct: 127 LESIPGFDIFFPDDNRFREIIKDVGVAII-GQTSSLAPADK-RFYATRDITATVDSIPLI 184
Query: 266 LASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGG 325
ASI++KK A G +++D+ G GA + T E + +LA+ + + G +T
Sbjct: 185 TASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMN 244
Query: 326 QPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVA-PRGMGKKVAREI 384
Q + + G A+E +EA++ L L + + L +L G +A + + +
Sbjct: 245 QVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAV 304
Query: 385 LESGKAYEKIKEIIEEQGGDPNI---KPEDIPIGDKTYTIHAQTSGYVTGIDNKAITAIA 441
L++GKA E ++ Q G + + +P T ++A T G+V+ +D +A+
Sbjct: 305 LDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAV 364
Query: 442 -------REAGAPEDKGAGVKLHVKVGEKVKEGDPLFTIHAESESRLDKA 484
R+A D G ++G++V PL IHA+ E+ +A
Sbjct: 365 VAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEA 414
>pir||C82899 thymidine phosphorylase UU368 [imported] - Ureaplasma urealyticum
>gi|6899350|gb|AAF30777.1|AE002134_1 (AE002134)
thymidine phosphorylase [Ureaplasma urealyticum]
Length = 433
Score = 138 bits (343), Expect = 2e-31
Identities = 113/400 (28%), Positives = 202/400 (50%), Gaps = 21/400 (5%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
V I KK +L + EI+ + V++ + + +++A + A+ G +E T AM
Sbjct: 5 VEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYATKAMV 64
Query: 152 ETGDMLD--IDRKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTAD 209
E+G +LD ++ K ++D HS GGV G+K +II+ P+++A GL + K S R + GT D
Sbjct: 65 ESGKLLDLRVENKIVVDKHSSGGV-GDKVSIILTPLLSALGLYVGKMSGRGLGHTGGTVD 123
Query: 210 VVEVFTNVTLSLD-EIKRIVEKI--GACLVWGGALNLAPADDLTIHVERRLSL--DPRGL 264
+E ++ L+LD ++K + ++ L+ G + ++ AD I+ R ++ D L
Sbjct: 124 KLE---SLNLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVADKY-IYALRDVTATSDVFDL 179
Query: 265 MLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYG 324
M+ SIM+KK A+ + YI +D+ G+GA + + +A SLA ++L KK + + +T
Sbjct: 180 MIGSIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNM 239
Query: 325 GQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLA-GILLEMGGVAPRGMGKKVARE 383
QP+G +G A+E KE+++ L+ P L + A IL++ + +
Sbjct: 240 DQPLGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDN 299
Query: 384 ILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDK-TYTIHAQTSGYVTGIDNKAITAIAR 442
++++G AY+K ++ GD D K I A+ GY+ K + IA
Sbjct: 300 VIKNGLAYQKFVNWVKWYKGDYISLENDTYFNPKYKLEILAKQDGYLDFKSTKELGMIAV 359
Query: 443 EAGAPE-------DKGAGVKLHVKVGEKVKEGDPLFTIHA 475
+ A D AG+ L+ K + VK + + T++A
Sbjct: 360 DLKAGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYA 399
>sp|P75052|TYPH_MYCPN THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|2146664|pir||S73416 thymidine
phosphorylase (EC 2.4.2.4) deoA - Mycoplasma pneumoniae
(strain ATCC 29342) >gi|1673745|gb|AAB95738.1|
(AE000011) thymidine phosphorylase [Mycoplasma
pneumoniae]
Length = 421
Score = 133 bits (332), Expect = 4e-30
Identities = 110/401 (27%), Positives = 196/401 (48%), Gaps = 20/401 (4%)
Query: 92 VRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMA 151
V I KK RG+ L + EI V + ++ L + ++SA + A+ G++ E+ LT AM
Sbjct: 4 VNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAVWFQGMNSKELFCLTKAMV 63
Query: 152 ETGDMLDIDR--KPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTAD 209
++G+ L + K +D HS GG+ G+K +I ++PI+ A ++ K S R + GT D
Sbjct: 64 KSGESLHFNHHSKLSVDKHSTGGI-GDKVSIALIPILTALDYSVAKLSGRGLGYTGGTID 122
Query: 210 VVE-VFTNVTLSLDEIKRIVEKIGACLVWGGALNLAPADDLTIHV-ERRLSLDPRGLMLA 267
+E V + E + ++++ C + G + +AP D + + + ++D L+ +
Sbjct: 123 KLEAVGVKTDFTPTEAQNLLDQ-NDCFIIGQSEGIAPVDKVLYALRDTTATVDSLPLIAS 181
Query: 268 SIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITYGGQP 327
S+MSKK AI + YI ID+ GKGA +T A+ LA+ + K+ + + + ++ Q
Sbjct: 182 SVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQV 241
Query: 328 IGYTVGPALEAKEALETL---MTGKGPGSLVEKALGLAGILLEMGGVAPRGMGKKVAREI 384
+G T+G ALE E + L T G + + IL+E + +
Sbjct: 242 LGKTIGNALEVLEVVHFLKRNWTEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHAT 301
Query: 385 LESGKAYEKIKEIIEEQGG--DPNIKPEDIPIGDKTYTIHAQTSG---YVTGIDNKAITA 439
LE K +++ + IE QG + + +++ + A SG Y + +D A+ +
Sbjct: 302 LEGEKPWQRFLKFIELQGSSWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVD-LAMVS 360
Query: 440 IAREAGAPE-----DKGAGVKLHVKVGEKVKEGDPLFTIHA 475
I+ AG D AG+KL + E VK GD + +++
Sbjct: 361 ISLGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELYS 401
>sp|P43050|TYPH_MYCHO THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|629359|pir||S42196 thymidine
phosphorylase (EC 2.4.2.4) - Mycoplasma hominis (SGC3)
>gi|2127601|pir||S72521 thymidine phosphorylase (EC
2.4.2.4) - Mycoplasma hominis (SGC3) (fragment)
>gi|415854|emb|CAA81645.1| (Z27121) Thymidine
Phosphorylase [Mycoplasma hominis]
Length = 272
Score = 110 bits (273), Expect = 3e-23
Identities = 78/222 (35%), Positives = 114/222 (51%), Gaps = 11/222 (4%)
Query: 264 LMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAITY 323
L+ +SIMSKK A GS IL+D+ G GA ++ + EA+ L K IE+GKKL + + V IT
Sbjct: 19 LIASSIMSKKLATGSNCILLDVKCGNGAFMKDINEAKKLGKLMIEIGKKLNRKIAVEITN 78
Query: 324 GGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPRGM-GKKVAR 382
QP+G T+G +E EA++TL G GP E LL + A + +K+
Sbjct: 79 MQQPLGKTIGNKIEVLEAIDTL-NGHGPKDFTEIIYSSGSTLLVLAQKAKDEVEARKMID 137
Query: 383 EILESGKAYEKIKEIIEEQGGDPNIKPEDIPIGDKTY--TIHAQTSGYVTGIDNKAITAI 440
E++ + KAY K E I QGG+ + +D + Y I A SGY+ +
Sbjct: 138 EVINNKKAYNKFLEWISRQGGNIKVFEKDSKWFNPQYKQEIIASQSGYLKIKSRIDFGLV 197
Query: 441 AREAGAPEDK-------GAGVKLHVKVGEKVKEGDPLFTIHA 475
A + GA K AG+ L+ E V +GD LFT+++
Sbjct: 198 AMKLGAGRSKKEDSIDYEAGIYLNKSSNEYVNKGDVLFTMYS 239
>gb|AAC44438.1| (U67196) thymidine/pyrimidine phosphorylase homolog [Thermotoga
maritima]
Length = 137
Score = 75.7 bits (183), Expect = 1e-12
Identities = 46/120 (38%), Positives = 69/120 (57%), Gaps = 3/120 (2%)
Query: 95 IKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALTIAMAETG 154
I KK GEKL + EIE +V V ++ + +++A + A+ LD +E T M +G
Sbjct: 7 ILKKRNGEKLSREEIEFMVGGYVKGEIPDYQMAAFLMAVYFRHLDEEETYYFTETMMSSG 66
Query: 155 DMLDIDRKPIMDV--HSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSAAGTADVVE 212
+LD+ P V HS GGV G+KT ++V P+VA+AG+ + K S RA+ GT D +E
Sbjct: 67 VVLDLSEIPGTKVNKHSTGGV-GDKTTLVVAPLVASAGVPVAKMSGRALGHTGGTIDKLE 125
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.316 0.137 0.376
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 182180456
Number of Sequences: 2977
Number of extensions: 8166960
Number of successful extensions: 18351
Number of sequences better than 1.0e-10: 25
Number of HSP's better than 0.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 18262
Number of HSP's gapped (non-prelim): 25
length of query: 507
length of database: 189,106,746
effective HSP length: 61
effective length of query: 446
effective length of database: 152,599,039
effective search space: 68059171394
effective search space used: 68059171394
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 167 (69.5 bits)