BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2002 (lig) DE:DNA ligase (lig)
(559 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75173 DNA ligase (lig) PAB2002 - Pyrococcus abyssi (strain... 1100 0.0
sp|O59288|DNLI_PYRHO PROBABLE THERMOSTABLE DNA LIGASE (POLYDEOXY... 1042 0.0
sp|P56709|DNLI_PYRFU THERMOSTABLE DNA LIGASE (POLYDEOXYRIBONUCLE... 1025 0.0
dbj|BAB15949.1| (AB042527) DNA ligase [Thermococcus kodakaraensis] 929 0.0
gi|11498231 DNA ligase (lig) [Archaeoglobus fulgidus] >gi|601498... 550 e-155
sp|P54875|DNLI_METTF DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 494 e-139
sp|Q50566|DNLI_METTH DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 493 e-138
sp|Q57635|DNLI_METJA DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 484 e-135
gb|AAG19323.1| (AE005027) DNA ligase; Lig [Halobacterium sp. NRC-1] 429 e-119
gb|AAD00532.1| (U82370) DNA ligase [Pyrobaculum aerophilum] 410 e-113
pir||G72709 probable DNA ligase APE1094 - Aeropyrum pernix (stra... 408 e-113
gb|AAK40535.1| DNA ligase (polydeoxyribonucleotide synthase (ATP... 405 e-112
gb|AAF61267.1|AF242877_1 (AF242877) DNA ligase [Sulfolobus shiba... 403 e-111
sp|Q02093|DNLI_ACIAM DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 400 e-110
pir||D70421 DNA ligase (ATP dependent) - Aquifex aeolicus >gi|29... 382 e-105
emb|CAC12273.1| (AL445066) DNA ligase related protein [Thermopla... 334 1e-90
pir||G70649 probable DNA ligase - Mycobacterium tuberculosis (st... 286 5e-76
gi|6320038 DNA ligase; Cdc9p [Saccharomyces cerevisiae] >gi|2506... 282 7e-75
emb|CAA27005.1| (X03246) put. DNA ligase (CDC9) (aa 1-755) [Sacc... 282 9e-75
emb|CAC01484.1| (AL391017) putative DNA ligase [Streptomyces coe... 277 2e-73
sp|P51892|DNL1_XENLA DNA LIGASE I (POLYDEOXYRIBONUCLEOTIDE SYNTH... 274 2e-72
gb|AAF47090.1| (AE003462) CG5602 gene product [Drosophila melano... 271 2e-71
sp|Q27474|DNLI_CAEEL PROBABLE DNA LIGASE (POLYDEOXYRIBONUCLEOTID... 270 4e-71
gi|6754544 ligase I, DNA, ATP-dependent [Mus musculus] >gi|13522... 269 5e-71
gb|AAF82585.1|AF276774_1 (AF276774) DNA ligase I [Rattus norvegi... 265 7e-70
gi|4557719 DNA ligase I [Homo sapiens] >gi|118773|sp|P18858|DNL1... 264 2e-69
gi|11425282 DNA ligase I [Homo sapiens] 264 2e-69
sp|P12000|DNLI_SCHPO DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 261 2e-68
sp|Q42572|DNLI_ARATH DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 238 2e-61
pir||T38123 dna ligase - fission yeast (Schizosaccharomyces pomb... 189 9e-47
gb|AAF79833.1|AC026875_13 (AC026875) T6D22.23 [Arabidopsis thali... 187 3e-46
gb|AAF18258.1|AC011438_20 (AC011438) T23G18.1 [Arabidopsis thali... 185 1e-45
pir||T37436 DNA ligase - vaccinia virus (strain Ankara) >gi|2772... 173 4e-42
gi|9634571 TA61R [Vaccinia virus (strain Tian Tan)] >gi|6969850|... 169 5e-41
gi|9791118 A50R; putative [Vaccinia virus] >gi|118775|sp|P20492|... 168 2e-40
gi|11499314 DNA ligase, putative [Archaeoglobus fulgidus] >gi|74... 168 2e-40
sp|P16272|DNLI_VACCV DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 167 3e-40
gi|9634713 ORF FPV043 DNA ligase [Fowlpox virus] >gi|7271541|gb|... 166 5e-40
sp|Q67480|DNLI_FOWPM DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 165 1e-39
gi|7710126 ligase III, DNA, ATP-dependent, isoform beta [Homo sa... 164 2e-39
gi|4504995 ligase III, DNA, ATP-dependent, isoform beta [Homo sa... 164 2e-39
gi|11425554 ligase III, DNA, ATP-dependent, isoform beta [Homo s... 164 2e-39
gi|11425557 ligase III, DNA, ATP-dependent, isoform alpha [Homo ... 164 2e-39
gi|9627683 J4R [Variola virus] >gi|461948|sp|P33798|DNLI_VARV DN... 164 3e-39
pir||T28595 DNA ligase (ATP) (EC 6.5.1.1) - variola major virus ... 164 3e-39
gi|9633358 K4R protein [variola minor virus] >gi|7514766|pir||A7... 164 3e-39
pir||S35791 DNA ligase (ATP) (EC 6.5.1.1) - Crithidia fasciculat... 162 1e-38
gi|11433698 DNA ligase IV [Homo sapiens] 158 1e-37
gi|4504997 DNA ligase IV [Homo sapiens] >gi|1706482|sp|P49917|DN... 155 9e-37
gb|AAC53003.1| (U66057) DNA ligase III-beta [Mus musculus] 154 2e-36
gi|6754546 ligase III, DNA, ATP-dependent [Mus musculus] >gi|391... 154 2e-36
gi|9633769 m133R [Myxoma virus] >gi|6523988|gb|AAF15021.1|AF1707... 152 8e-36
gb|AAF54801.1| (AE003695) CG17227 gene product [Drosophila melan... 144 2e-33
gb|AAF91284.1|AF233527_1 (AF233527) DNA ligase IV [Arabidopsis t... 141 1e-32
gb|AAA67138.1| (U00761) ATP-dependent DNA ligase [Rabbit fibroma... 137 3e-31
gi|9633943 gp133R [Rabbit fibroma virus] >gi|6578662|gb|AAF18016... 137 3e-31
emb|CAA21085.2| (AL031740) dna ligase [Schizosaccharomyces pombe] 127 3e-28
pir||T40845 dna ligase - fission yeast (Schizosaccharomyces pombe) 127 3e-28
dbj|BAA97366.1| (AB023042) contains similarity to DNA ligase~gen... 127 4e-28
gi|9630988 DNA ligase [Lymantria dispar nucleopolyhedrovirus] >g... 127 4e-28
emb|CAB92891.1| (AL356932) probable ATP-dependent DNA ligase. [S... 123 6e-27
pir||C83378 probable ATP-dependent DNA ligase PA2138 [imported] ... 115 2e-24
pir||T35025 probable DNA ligase - Streptomyces coelicolor >gi|51... 111 3e-23
sp|P71571|Y938_MYCTU HYPOTHETICAL 83.6 KDA PROTEIN RV0938 >gi|74... 110 5e-23
pir||T38940 dna ligase - fission yeast (Schizosaccharomyces pomb... 108 1e-22
pir||S31138 hypothetical protein 3 (SFA 5' region) - yeast (Sacc... 100 5e-20
pir||S74315 CDC9 protein - Saccharomyces cerevisiae >gi|600039|e... 99 1e-19
gb|AAF48298.1| (AE003493) CG12176 gene product [Drosophila melan... 97 4e-19
pir||D70797 probable DNA ligas - Mycobacterium tuberculosis (str... 83 6e-15
gi|6324578 ATP dependent DNA ligase; Dnl4p [Saccharomyces cerevi... 83 1e-14
dbj|BAB05928.1| (AP001514) unknown conserved protein [Bacillus h... 80 8e-14
pir||S71741 DNA ligase (ATP) (EC 6.5.1.1) - yeast (Candida albic... 75 2e-12
sp|P52496|DNLI_CANAL DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHAS... 74 5e-12
emb|CAA64457.2| (X95001) ATP-dependent DNA ligase [Candida albic... 74 5e-12
>pir||B75173 DNA ligase (lig) PAB2002 - Pyrococcus abyssi (strain Orsay)
>gi|5457975|emb|CAB49465.1| (AJ248284) DNA ligase (lig)
[Pyrococcus abyssi]
Length = 559
Score = 1100 bits (2815), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV
Sbjct: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
Query: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTL 120
GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTL
Sbjct: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTL 120
Query: 121 VKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFN 180
VKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFN
Sbjct: 121 VKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFN 180
Query: 181 VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEM 240
VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEM
Sbjct: 181 VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEM 240
Query: 241 GGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGEL 300
GGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGEL
Sbjct: 241 GGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGEL 300
Query: 301 VAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKK 360
VAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKK
Sbjct: 301 VAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKK 360
Query: 361 LEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
LEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK
Sbjct: 361 LEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
Query: 421 IKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
IKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT
Sbjct: 421 IKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
Query: 481 KMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDAD 540
KMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDAD
Sbjct: 481 KMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDAD 540
Query: 541 TIERIAQLYELQERMKGKV 559
TIERIAQLYELQERMKGKV
Sbjct: 541 TIERIAQLYELQERMKGKV 559
>sp|O59288|DNLI_PYRHO PROBABLE THERMOSTABLE DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE
[ATP]) >gi|7447286|pir||F71041 probable DNA ligase -
Pyrococcus horikoshii >gi|3258051|dbj|BAA30734.1|
(AP000006) 559aa long hypothetical DNA ligase
[Pyrococcus horikoshii]
Length = 559
Score = 1042 bits (2666), Expect = 0.0
Identities = 518/559 (92%), Positives = 547/559 (97%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
M+YIELAQLYQKLEKTTMKLIKTRLVADFLK+VPEDHL+FIPYLILGDVFPEWDERELGV
Sbjct: 1 MKYIELAQLYQKLEKTTMKLIKTRLVADFLKRVPEDHLDFIPYLILGDVFPEWDERELGV 60
Query: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTL 120
GEKLLIKAVSMATG+D KEIENSVKDTGDLGESIALA+K+RKQKSFFSQPLTIKRVYQTL
Sbjct: 61 GEKLLIKAVSMATGVDPKEIENSVKDTGDLGESIALAIKRRKQKSFFSQPLTIKRVYQTL 120
Query: 121 VKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFN 180
VK+AETTGEGSQ+KKMKYLANLFMDAEP+EAKY+ARTVLGTMRTGVAEGLLRDAI+LAF+
Sbjct: 121 VKIAETTGEGSQEKKMKYLANLFMDAEPLEAKYLARTVLGTMRTGVAEGLLRDAIALAFH 180
Query: 181 VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEM 240
VKVELVERAYMLTSDFGFVAKIAK EGN+GL KVTIQ+GKPIKPMLAQQAANIKEALLEM
Sbjct: 181 VKVELVERAYMLTSDFGFVAKIAKAEGNEGLEKVTIQLGKPIKPMLAQQAANIKEALLEM 240
Query: 241 GGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGEL 300
GGEAEFEIKYDGARVQVHKDGEKV IYSRRLENVTRAIPEIVEAIKEA++P K IVEGEL
Sbjct: 241 GGEAEFEIKYDGARVQVHKDGEKVIIYSRRLENVTRAIPEIVEAIKEAIEPEKVIVEGEL 300
Query: 301 VAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKK 360
VAIGE+GRPLPFQYVLRRFRRK+NIEEMM+KIPLELNLFDVLYVDG S +DTKF+ERRKK
Sbjct: 301 VAIGEEGRPLPFQYVLRRFRRKHNIEEMMKKIPLELNLFDVLYVDGKSFVDTKFIERRKK 360
Query: 361 LEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
LEEIV+ NGK+K+AENLITKN EEAE+FYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK
Sbjct: 361 LEEIVKPNGKIKVAENLITKNAEEAEKFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
Query: 421 IKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
IKPTMENLDLVIIGAEWGEGRRAHL GSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT
Sbjct: 421 IKPTMENLDLVIIGAEWGEGRRAHLFGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
Query: 481 KMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDAD 540
KMLKPLI+KEEGKRV IQPK+VIEVTYQEIQKSPKYRSGFALRFPRYVALR+DKGPEDAD
Sbjct: 481 KMLKPLIVKEEGKRVVIQPKIVIEVTYQEIQKSPKYRSGFALRFPRYVALRDDKGPEDAD 540
Query: 541 TIERIAQLYELQERMKGKV 559
TIERIAQLYELQER+KGKV
Sbjct: 541 TIERIAQLYELQERIKGKV 559
>sp|P56709|DNLI_PYRFU THERMOSTABLE DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
(PFU DNA LIGASE)
Length = 561
Score = 1025 bits (2622), Expect = 0.0
Identities = 507/559 (90%), Positives = 545/559 (96%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
MRY+ELAQLYQKLEKTTMKLIKTRLVADFLKKVP+DHLEFIPYLILG+VFPEWDERELGV
Sbjct: 1 MRYLELAQLYQKLEKTTMKLIKTRLVADFLKKVPDDHLEFIPYLILGEVFPEWDERELGV 60
Query: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTL 120
GEKLLIKAV+MATGID+KEIE SVKDTGDLGESIALAVKK+KQKSFFSQPLTIKRVYQTL
Sbjct: 61 GEKLLIKAVAMATGIDAKEIEESVKDTGDLGESIALAVKKKKQKSFFSQPLTIKRVYQTL 120
Query: 121 VKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFN 180
VKVAETTGEGSQDKK+KYLA+LFMDAEP+EAKY+ART+LGTMRTGVAEGLLRDAI++AF+
Sbjct: 121 VKVAETTGEGSQDKKVKYLADLFMDAEPLEAKYLARTILGTMRTGVAEGLLRDAIAMAFH 180
Query: 181 VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEM 240
VKVELVERAYMLTSDFG+VAKIAK EGN+GLAKV +Q+GKPIKPMLAQQAA+I++ALLEM
Sbjct: 181 VKVELVERAYMLTSDFGYVAKIAKLEGNEGLAKVQVQLGKPIKPMLAQQAASIRDALLEM 240
Query: 241 GGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGEL 300
GGEAEFEIKYDGARVQVHKDG K+ +YSRRLENVTRAIPEIVEA+KEA+ P KAIVEGEL
Sbjct: 241 GGEAEFEIKYDGARVQVHKDGSKIIVYSRRLENVTRAIPEIVEALKEAIIPEKAIVEGEL 300
Query: 301 VAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKK 360
VAIGE+GRPLPFQYVLRRFRRK+NIEEMMEKIPLELNLFDVLYVDG SLIDTKF++RR+
Sbjct: 301 VAIGENGRPLPFQYVLRRFRRKHNIEEMMEKIPLELNLFDVLYVDGQSLIDTKFIDRRRT 360
Query: 361 LEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
LEEI++ N K+K+AENLITK VEEAE FYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK
Sbjct: 361 LEEIIKQNEKIKVAENLITKKVEEAEAFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
Query: 421 IKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
IKPTMENLDLVIIGAEWGEGRRAHL GSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT
Sbjct: 421 IKPTMENLDLVIIGAEWGEGRRAHLFGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
Query: 481 KMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDAD 540
KMLKPLIIKEEGKRVW+QPKVVIEVTYQEIQKSPKYRSGFALRFPR+VALR+DKGPEDAD
Sbjct: 481 KMLKPLIIKEEGKRVWLQPKVVIEVTYQEIQKSPKYRSGFALRFPRFVALRDDKGPEDAD 540
Query: 541 TIERIAQLYELQERMKGKV 559
TIERIAQLYELQE+MKGKV
Sbjct: 541 TIERIAQLYELQEKMKGKV 559
>dbj|BAB15949.1| (AB042527) DNA ligase [Thermococcus kodakaraensis]
Length = 562
Score = 929 bits (2376), Expect = 0.0
Identities = 452/558 (81%), Positives = 514/558 (92%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
MRY ELA LY++LEKTT+K +KT+ VADFLKK P++ LE +PYLILG VFP+WDERELGV
Sbjct: 4 MRYSELADLYRRLEKTTLKTLKTKFVADFLKKTPDELLEIVPYLILGKVFPDWDERELGV 63
Query: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTL 120
GEKLLIKAVSMATG+ KEIE+SV+DTGDLGES+ALA+KK+KQKSFFSQPLTIKRVY T
Sbjct: 64 GEKLLIKAVSMATGVPEKEIEDSVRDTGDLGESVALAIKKKKQKSFFSQPLTIKRVYDTF 123
Query: 121 VKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFN 180
VK+AE GEGSQD+KMKYLANLFMDAEP E KY+ARTVLGTMRTGVAEG+LRDAI+ AF
Sbjct: 124 VKIAEAQGEGSQDRKMKYLANLFMDAEPEEGKYLARTVLGTMRTGVAEGILRDAIAEAFR 183
Query: 181 VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEM 240
VK ELVERAYMLTSDFG+VAKIAK EGN+GL+KV IQIGKPI+PMLAQ AA++K+AL+EM
Sbjct: 184 VKPELVERAYMLTSDFGYVAKIAKLEGNEGLSKVRIQIGKPIRPMLAQNAASVKDALIEM 243
Query: 241 GGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGEL 300
GGEA FEIKYDGARVQVHKDG+KV +YSRRLENVTR+IPE++EAIK ALKP KAIVEGEL
Sbjct: 244 GGEAAFEIKYDGARVQVHKDGDKVIVYSRRLENVTRSIPEVIEAIKAALKPEKAIVEGEL 303
Query: 301 VAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKK 360
VA+GE+GRP PFQYVLRRFRRKYNI+EM+EKIPLELNLFDV++VDG SLI+TKF++RR K
Sbjct: 304 VAVGENGRPRPFQYVLRRFRRKYNIDEMIEKIPLELNLFDVMFVDGESLIETKFIDRRNK 363
Query: 361 LEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
LEEIV+ + K+K+AE LITK VEEAE FY+RALE+GHEGLMAKRLD++YEPGNRGKKWLK
Sbjct: 364 LEEIVKESEKIKLAEQLITKKVEEAEAFYRRALELGHEGLMAKRLDSIYEPGNRGKKWLK 423
Query: 421 IKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
IKPTMENLDLVIIGAEWGEGRRAHLLGSF++ AYDP +GEFL VGKVGSGFTD+DLVEFT
Sbjct: 424 IKPTMENLDLVIIGAEWGEGRRAHLLGSFLVAAYDPHSGEFLPVGKVGSGFTDEDLVEFT 483
Query: 481 KMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDAD 540
KMLKP I+++EGK V I+PK VIEVTYQEIQKSPKY+SGFALRFPRYVALREDK PE+AD
Sbjct: 484 KMLKPYIVRQEGKFVEIEPKFVIEVTYQEIQKSPKYKSGFALRFPRYVALREDKSPEEAD 543
Query: 541 TIERIAQLYELQERMKGK 558
TIER+A+LYELQER K K
Sbjct: 544 TIERVAELYELQERFKAK 561
>gi|11498231 DNA ligase (lig) [Archaeoglobus fulgidus]
>gi|6014986|sp|O29632|DNLI_ARCFU DNA LIGASE
(POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|7447287|pir||G69327 DNA ligase (lig) homolog -
Archaeoglobus fulgidus >gi|2649996|gb|AAB90616.1|
(AE001061) DNA ligase (lig) [Archaeoglobus fulgidus]
Length = 556
Score = 550 bits (1401), Expect = e-155
Identities = 278/557 (49%), Positives = 390/557 (69%), Gaps = 5/557 (0%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDH-LEFIPYLILGDVFPEWDERELG 59
M + E A+ ++LEK + L T +A FL+K+ ++ L + I G V+P WDERELG
Sbjct: 2 MLFAEFAEFCERLEKISSTLELTARIAAFLQKIEDERDLYDVVLFITGKVYPPWDERELG 61
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQT 119
VG LL +A+ +G+ EIE+ +++ GDLG +KK+K + + LT+++V +T
Sbjct: 62 VGIGLLYEALENVSGVKRSEIESMIREYGDLGLVAEQLIKKKKMTTLAFEELTVRKVRET 121
Query: 120 LVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAF 179
++A TGEGS +K+ L L+ A P+EA+Y+ R +L MR GV EG++RDAI+ AF
Sbjct: 122 FDEIASLTGEGSMKRKIMLLTGLYGLATPLEARYLTRLILNEMRLGVGEGIMRDAIARAF 181
Query: 180 NVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLE 239
E VERAYM+T+D G VA +AK EG +GL K+ I+I P++ MLAQ A +++ A+ E
Sbjct: 182 RADPETVERAYMITNDLGRVAVVAKKEGEEGLRKMKIEIHIPVRMMLAQVAESLESAVRE 241
Query: 240 MGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGE 299
M A E K+DG+RVQVH DG +VTIYSRRLENVT A+P+IVE IK+++KP I++GE
Sbjct: 242 MR-TAAVEWKFDGSRVQVHWDGSRVTIYSRRLENVTNALPDIVEEIKKSVKPG-VILDGE 299
Query: 300 LVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRK 359
++A+ E G+P+PFQ+VLRRFRRK+++ +M+EKIPLE + FD+LY DG ID ERRK
Sbjct: 300 VIAVKE-GKPMPFQHVLRRFRRKHDVAKMVEKIPLEAHFFDILYHDG-ECIDLPLRERRK 357
Query: 360 KLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWL 419
LE V + K+K+A+ ++T +V+E + Y A+ GHEG+M K + Y PG RGK WL
Sbjct: 358 LLESAVNESEKIKLAKQIVTDSVDEVRKMYDEAISAGHEGVMIKLPSSPYIPGKRGKNWL 417
Query: 420 KIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEF 479
K+K ME LDLV++G EWGEG+R+H L SF L DP TG+ L+VG+V +GFT++DL E
Sbjct: 418 KVKAIMETLDLVVVGGEWGEGKRSHWLSSFELACLDPVTGKLLKVGRVATGFTEEDLEEL 477
Query: 480 TKMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDA 539
T+M +PLI+ ++GK+V PK V EV YQEIQKSPKY SG+ALRFPR+V LR+DK ++A
Sbjct: 478 TEMFRPLIVSQQGKKVEFIPKYVFEVAYQEIQKSPKYESGYALRFPRFVRLRDDKDVDEA 537
Query: 540 DTIERIAQLYELQERMK 556
DTIER+ LY+LQ +K
Sbjct: 538 DTIERVENLYKLQFEVK 554
>sp|P54875|DNLI_METTF DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|1279773|gb|AAC44823.1| (U52681) DNA ligase
[Methanobacterium thermoformicicum]
Length = 557
Score = 494 bits (1259), Expect = e-139
Identities = 244/551 (44%), Positives = 377/551 (68%), Gaps = 6/551 (1%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGE 62
Y+ELA++Y +LE TT +L KT ++A+ L+ V ++ L + L+LG VFP W E ELGVG
Sbjct: 6 YMELAEVYHRLESTTKRLEKTEILAELLRSVDKELLPDVTILMLGRVFPIWSEEELGVGI 65
Query: 63 KLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTLVK 122
KLL+KA+S+ G+ EIE+ +++ GD+G + ++ Q +FFSQPLT++ VY L
Sbjct: 66 KLLMKAISLVVGVSMDEIEDEIREQGDIGLASEKLFSRKTQTTFFSQPLTVEFVYSRLKA 125
Query: 123 VAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVK 182
+A +G+ +Q KK+ L + A+P+EA+YI RTVL +R GVAEG++RDAI+ AF V
Sbjct: 126 LASASGDRAQSKKINILVEVLSQAKPLEARYITRTVLEELRVGVAEGIIRDAIARAFEVD 185
Query: 183 VELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGG 242
LVERA+MLT+D G VA +A+ EG GL ++ ++ G+P+KPMLAQ A++I+ A+ E+ G
Sbjct: 186 PALVERAHMLTNDLGMVAAVAREEGEPGLGRLNLEPGRPVKPMLAQLASSIESAITEL-G 244
Query: 243 EAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGELVA 302
A E KYDG RVQ+H+ G++V+I++RRLEN+T A+PEI+E ++EAL IVEGE++
Sbjct: 245 RAFCETKYDGIRVQIHRCGDEVSIFTRRLENITAAVPEILEGVEEALPADDYIVEGEII- 303
Query: 303 IGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLE 362
+ DGRP FQY+L+R RRKY+++ + ++PL L LFDVLY G LID RR+ LE
Sbjct: 304 VTMDGRPASFQYILQRVRRKYDVDRLTREVPLSLFLFDVLYHRG-PLIDEPLWHRREVLE 362
Query: 363 EIV-ETNGKVKIAE--NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWL 419
I+ E G+V+ + ++ N+++A +K ++ GHEG+M K +A Y PG RGKK L
Sbjct: 363 SILSEIPGRVEASRMVDVGPDNLDDALWLFKESIREGHEGIMIKDTEAPYIPGIRGKKML 422
Query: 420 KIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEF 479
K K E LDL+++G +G G+RAHL+GS++L D ++GE + V +G D L +
Sbjct: 423 KFKAEPETLDLIVVGGTYGRGKRAHLVGSYLLAVRDEKSGELKTIAHVATGLDDQTLQDL 482
Query: 480 TKMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDA 539
++ ++ L ++ G+++ ++P++++EV Y EI +SP+Y SG++LRFP +R+D P+D
Sbjct: 483 SERMENLKVERRGRKIRVKPEIILEVAYSEIVRSPEYESGYSLRFPVVKRIRDDLSPDDI 542
Query: 540 DTIERIAQLYE 550
DT+ R+ L++
Sbjct: 543 DTLGRVISLFK 553
>sp|Q50566|DNLI_METTH DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|7447283|pir||H69077 DNA ligase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|1272332|gb|AAC44812.1| (U51624) putative DNA ligase
[Methanobacterium thermoautotrophicum]
>gi|2622703|gb|AAB86053.1| (AE000918) DNA ligase
[Methanobacterium thermoautotrophicum]
Length = 561
Score = 493 bits (1255), Expect = e-138
Identities = 245/551 (44%), Positives = 378/551 (68%), Gaps = 6/551 (1%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGE 62
Y+ELA++Y +LE TT +L KT ++A+ L+ V ++ L + L+LG VFP W E ELGVG
Sbjct: 6 YMELAEVYHRLESTTKRLEKTEILAELLRSVDKELLPDVTILMLGRVFPIWSEEELGVGI 65
Query: 63 KLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTLVK 122
KLL+KA+S+ G+ EIE+ +++ GD+G + ++ Q +FFSQPLT++ VY L
Sbjct: 66 KLLMKAISLVVGVSMDEIEDEIREQGDIGLASEKLFSRKTQTTFFSQPLTVEFVYSRLKA 125
Query: 123 VAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVK 182
+A +G+ +Q KK+ L + A+P+EA+YI RTVL +R GVAEG++RDAI+ AF V
Sbjct: 126 LASASGDRAQSKKINILVEVLSQAKPLEARYITRTVLEELRVGVAEGIIRDAIARAFEVD 185
Query: 183 VELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGG 242
LVERA+MLT+D G VA +A+ EG GL ++ ++ G+P+KPMLAQ A++I+ A+ E+ G
Sbjct: 186 PALVERAHMLTNDLGMVAAVAREEGEPGLGRLNLEPGRPVKPMLAQLASSIESAITEL-G 244
Query: 243 EAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGELVA 302
A E KYDG RVQ+H+ G++++I++RRLEN+T A+PEI+E ++EAL IVEGE++
Sbjct: 245 RAFCETKYDGIRVQIHRCGDEISIFTRRLENITAAVPEILEGVEEALPADDYIVEGEII- 303
Query: 303 IGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLE 362
+ DGRP FQY+L+R RRKY++E + ++PL L LFDVLY LID RR+ LE
Sbjct: 304 VTMDGRPASFQYILQRVRRKYDVERLTREVPLSLFLFDVLY-HREPLIDEPLRHRREVLE 362
Query: 363 EIV-ETNGKVKIAE--NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWL 419
I+ E G+V+ + ++ N+ +A ++ ++ GHEG+M K +A Y PG RGKK L
Sbjct: 363 SILSEIPGRVEASRMVDVGPDNLNDALWLFEESIREGHEGIMIKDTEAPYIPGIRGKKML 422
Query: 420 KIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEF 479
K K E LDL+++G +G G+RAHL+GS++L A D ++G+ + V V +G D+ L +
Sbjct: 423 KFKAEPETLDLIVVGGTYGRGKRAHLVGSYLLAARDEDSGDLVTVAHVATGLDDETLQQL 482
Query: 480 TKMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDA 539
++ ++ L I+ +G+++ ++P++++EV Y EI KSP+Y SG++LRFP +R+D +D
Sbjct: 483 SERMEKLAIERKGRKLLVRPEIILEVAYSEIVKSPEYESGYSLRFPVVKRIRDDLCLDDV 542
Query: 540 DTIERIAQLYE 550
DT+ RI L++
Sbjct: 543 DTVGRIESLFQ 553
>sp|Q57635|DNLI_METJA DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|2127855|pir||D64321 DNA ligase (ATP) (EC 6.5.1.1) -
Methanococcus jannaschii >gi|1590924|gb|AAB98156.1|
(U67474) DNA ligase (lig) [Methanococcus jannaschii]
Length = 573
Score = 484 bits (1232), Expect = e-135
Identities = 269/578 (46%), Positives = 380/578 (65%), Gaps = 27/578 (4%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPE----DHLEFIPYLILGDVFPEWDER 56
M + ++ +++ K+EKTT +L K + V E + L+ I Y+ +G V+PE+DER
Sbjct: 1 MLWRDVCEIFNKIEKTTKRLEKRDYFIKLIDMVKEKGKPEDLKKICYMAIGRVYPEYDER 60
Query: 57 ELGVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRV 116
ELG+GEKLLI AV+ + GI E+ +K+TGD+G +I K KQ S F QPLT+ V
Sbjct: 61 ELGIGEKLLINAVT-SIGIKKDELLEKIKETGDIGLAIEQLKSKIKQASLFFQPLTVDEV 119
Query: 117 YQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAIS 176
Y+TL +V E GEGSQ KK++ +++LF+ A PIE +Y+AR +L MR G+ + DA+S
Sbjct: 120 YETLKRVGEIEGEGSQKKKLRLISSLFLRASPIECRYLARLILEDMRIGMNVPTILDALS 179
Query: 177 LAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEA 236
+ FNV E +E+ Y +T+D G +A+ G+ ++ +++ +PIKPMLAQ +I+EA
Sbjct: 180 VYFNVPKEKLEKIYAITNDIGLLAE-KLLMGDLESEELKLKLFRPIKPMLAQLTPSIEEA 238
Query: 237 LLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIV 296
LLEM G A+FE KYDGARVQ+HKDG KV IYSRRLE+VT A+PEIVEA+K + K IV
Sbjct: 239 LLEM-GRAQFETKYDGARVQIHKDGNKVKIYSRRLEDVTNALPEIVEAVKN-INVDKLIV 296
Query: 297 EGELVAIG-EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFM 355
EGE VAI + G+P PFQ +LRRFRRKY+I +MM++I L + LFD+LY DGVS ID +F
Sbjct: 297 EGECVAIDKQTGKPRPFQDILRRFRRKYDIGKMMKEINLRVYLFDILYKDGVSFIDEEFE 356
Query: 356 ERRKKLEEIV-----------------ETNGKVKIAENLITKNVEEAEQFYKRALEMGHE 398
+RRK LEEIV +++ + I+ L+T + +EA +FY +L +GHE
Sbjct: 357 KRRKVLEEIVGYENDWRTERKRIEKELKSDKIIDISYKLVTNDAKEAREFYNWSLSIGHE 416
Query: 399 GLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPET 458
G+M K L A Y PG+R + K KPT+E+LD+VI A+ G G+R GSF + D E
Sbjct: 417 GVMIKNLKAPYTPGSRVRTMYKFKPTLESLDVVITKAKRGMGKRKDWYGSFEICVRD-EE 475
Query: 459 GEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRS 518
G +G VG+G T+ DL + + +II++ G+ V ++PK+VIEV Y+EIQKS KY
Sbjct: 476 GNLYPIGHVGTGLTEADLEFLKEEIDKIIIRDLGEEVEVEPKIVIEVAYEEIQKSDKYPC 535
Query: 519 GFALRFPRYVALREDKGPEDADTIERIAQLYELQERMK 556
G+ALRFPR V R DKG + +TIE + ++YE+Q K
Sbjct: 536 GYALRFPRVVRFRFDKGVNEINTIEDVERIYEIQRGRK 573
>gb|AAG19323.1| (AE005027) DNA ligase; Lig [Halobacterium sp. NRC-1]
Length = 561
Score = 429 bits (1092), Expect = e-119
Identities = 243/568 (42%), Positives = 348/568 (60%), Gaps = 21/568 (3%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
M++ A +E T L LVA+ D L+ + + G VFP E +L +
Sbjct: 1 MKFGSFATFAADIEATDADLDVVALVAELFDAADSD-LDVVARFVQGRVFPAHSETKLDI 59
Query: 61 GEKLLIKAVSMATG--IDSKEIENSVKDTGDLGESIALAVKKRKQKSF--------FSQP 110
G +L A+S A G +D+ +IE + +TGD+G ++A ++ Q +
Sbjct: 60 GPQLCYTALSRAAGRNVDADDIEARLAETGDIG-AVAGSLDLGGQTGLAAFGGGDDHADG 118
Query: 111 LTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGL 170
LT+ V L +A G+GSQ +K+ L LF EA+Y+AR VLG MR GV EG
Sbjct: 119 LTVSGVADELAALAAAAGDGSQSEKVTLLFGLFNQCTSREARYLARLVLGEMRIGVGEGA 178
Query: 171 LRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQA 230
+RDAI+ AF+V V+RA +++D+G VA+ A+ G D L + +++G+P++ MLAQ A
Sbjct: 179 VRDAIAEAFDVPTAAVQRALQVSNDYGLVAETARDSGTDALDAMGLEVGRPVQAMLAQ-A 237
Query: 231 ANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALK 290
+ +AL E EA E K+DGARVQVH DG+ V +YSR +ENVT A+PE+VE ++ +
Sbjct: 238 GTVTDALDEWH-EAAVETKFDGARVQVHYDGDDVVLYSRNMENVTGALPELVEFVENNVT 296
Query: 291 PTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVD----G 346
I++GE VA EDG PLPFQ +L+RFRRK+++ M E+I +EL+ FD L+ G
Sbjct: 297 -APVIIDGEAVAADEDGDPLPFQEILKRFRRKHDVAAMREEISVELHAFDCLHAPSADGG 355
Query: 347 VSLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLD 406
L+D F +R ++L +V+ V +E L+T + +E F ALE GHEG+M K
Sbjct: 356 EDLLDAPFSDRHRRLRSVVDDASAV--SEVLVTDDADEIAAFEATALEGGHEGIMLKNPA 413
Query: 407 AVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGK 466
A Y PG+RGK WLK KP +E LDLV+ GAEWGEGRRA +LG+F+L A D F +GK
Sbjct: 414 APYTPGDRGKDWLKRKPDVETLDLVVTGAEWGEGRRASVLGTFLLSARDAAGDGFETIGK 473
Query: 467 VGSGFTDDDLVEFTKMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPR 526
V +G TD++L + L+P + E+G+ V I+P VV+EV Y+EIQ SP Y SG+ALRFPR
Sbjct: 474 VATGLTDEELAALSDRLEPHVRSEDGQTVDIEPAVVLEVGYEEIQASPTYSSGYALRFPR 533
Query: 527 YVALREDKGPEDADTIERIAQLYELQER 554
+V++REDK P ADTIER+ +L Q++
Sbjct: 534 FVSVREDKTPTTADTIERVERLAAQQQQ 561
>gb|AAD00532.1| (U82370) DNA ligase [Pyrobaculum aerophilum]
Length = 589
Score = 410 bits (1042), Expect = e-113
Identities = 246/583 (42%), Positives = 344/583 (58%), Gaps = 31/583 (5%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
+++ EL + +E TT + +L+ KK + + I Y ILGD+ P W+ ELGV
Sbjct: 6 VQFGELVKALAAIEATTQRTTMVKLLVSLFKKASPEEVGKIVYFILGDLRPPWEGVELGV 65
Query: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESI--ALAVKKRKQKSFFS--QPLTIKRV 116
EKL ++AVS ATG E+E K TGD+GE+ ALA KR F +PL + V
Sbjct: 66 AEKLCLRAVSKATGAAVSELEALYKKTGDVGEAARRALAASKRPGLLAFGSQKPLEVSEV 125
Query: 117 YQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAIS 176
Y TL+KVA TGEG+QD K+ L++LF A P E KYIAR V+G +R GVA+ + +A+S
Sbjct: 126 YDTLLKVARATGEGAQDMKVALLSSLFARATPEEGKYIARFVVGKLRLGVADMTIIEALS 185
Query: 177 LAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEA 236
A+ V E +E+AY + D G +AK EG L ++ I G P+ PMLAQ+ ++ E
Sbjct: 186 DAYGVNKEALEKAYHIYPDLGRLAKHV-AEGKP-LDEIRITPGVPVLPMLAQRLSSASEI 243
Query: 237 LLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIV 296
L ++GG A E KYDG R Q+H V I+SRRLE++T A P++V+A+KEA+ +AI+
Sbjct: 244 LAKLGGSAICEYKYDGERAQIHLTPGGVKIFSRRLEDITHAYPDVVKAVKEAVSAKEAIL 303
Query: 297 EGELVAIGED-GRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFM 355
EGE+VA+ D G LPFQ ++ R +RK+++ +E P L LFDVLYVDG L + +
Sbjct: 304 EGEIVAVDPDTGDMLPFQELMHR-KRKHDVATAVELYPTVLYLFDVLYVDGEDLTEEPLI 362
Query: 356 ERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRG 415
RR +L EIV KV IA+ I N E + F+ ++ MG EGL+ K ++YE G RG
Sbjct: 363 YRRVRLSEIVCETDKVSIAKWRIFDNAEAVDVFFHESVSMGTEGLICKSPSSIYEMGARG 422
Query: 416 KKWLKIK-----PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSG 470
W+K K ++ +DLV++GA G G+RA L G+F+L AYDP T F V KVGSG
Sbjct: 423 WNWIKYKRDYRSEMIDTVDLVVVGAFHGRGKRAGLYGAFLLAAYDPSTDMFYTVCKVGSG 482
Query: 471 FTDDDLVEFTKMLKPLIIKEEGKR--------VWIQPKVVIEVTYQEIQKSPKYRS---- 518
FTD DL + ++L+P I R VW P+VVIEV EI SP +
Sbjct: 483 FTDADLKKMYEILQPFKIPHRHPRVVSKMEADVWFVPQVVIEVIGAEITLSPLHTCCLGA 542
Query: 519 -----GFALRFPRYVA-LREDKGPEDADTIERIAQLYELQERM 555
G A+RFPR+ R DK PE A T+ + +LY+ Q+++
Sbjct: 543 VRPGVGLAVRFPRFTGRYRSDKSPEQATTVAEMLELYKRQKKV 585
>pir||G72709 probable DNA ligase APE1094 - Aeropyrum pernix (strain K1)
>gi|5104764|dbj|BAA80079.1| (AP000060) 619aa long
hypothetical DNA ligase [Aeropyrum pernix]
Length = 619
Score = 408 bits (1037), Expect = e-113
Identities = 231/594 (38%), Positives = 350/594 (58%), Gaps = 41/594 (6%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDER-ELG 59
M + +A+ + +E+ T + T L+ K P + + YLI G + P+W ELG
Sbjct: 18 MPFKPVAEAFASMERITSRTQLTLLLTRLFKSTPPGAIGIVVYLIQGKLGPDWKGLPELG 77
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLG---ESIALAVKKRKQKSFF--------S 108
VGEKLL+KA+++A + +E K GDLG E ++ + R ++
Sbjct: 78 VGEKLLVKAIALAYKATEERVERLYKSVGDLGSVAERLSREYRSRAARAVTLEAFMAGGG 137
Query: 109 QPLTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAE 168
+ LT++RVY TL ++A GEGS+D K++ LA L DAEP+EAKYI R V G +R GV +
Sbjct: 138 EALTVRRVYNTLYRIAMAQGEGSRDIKLRLLAGLLADAEPVEAKYIVRFVEGRLRVGVGD 197
Query: 169 GLLRDAISLAFNVKVE---LVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPM 225
+ DA+++AF ++ERAY L +D G++A++ EG D L V Q+G PI+PM
Sbjct: 198 ATVLDALAMAFGGGAHARPVIERAYNLRADLGYIAEVVAREGVDALRGVKPQVGVPIRPM 257
Query: 226 LAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAI 285
LA++ + E L ++GG A E KYDG R Q+HK +V IYSRRLEN+TR P++VE
Sbjct: 258 LAERGRDPAEILRKVGGRAVVEYKYDGERAQIHKKDGEVYIYSRRLENITRMFPDVVEMA 317
Query: 286 KEALKPTKAIVEGELVAIGEDGRPL-PFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYV 344
++ LK +AIVEGE+VA+ D + PFQ +++R +RK++I +M ++P+ + LFD LYV
Sbjct: 318 RKGLKAGEAIVEGEIVAVDPDNYEIQPFQVLMQR-KRKHDIHRVMREVPVAVFLFDALYV 376
Query: 345 DGVSLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKR 404
DG L ERR++L+EIV ++AE++ T + EE F+ +A+E G EG+M K
Sbjct: 377 DGEDLTSKPLPERRRRLKEIVVETPLWRLAESIETSDPEELWTFFLKAIEEGAEGVMVKA 436
Query: 405 L--DAVYEPGNRGKKWLKIK-----PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPE 457
+ D+VY G RG W+K+K M+ +DLV++GA +G G+R L S ++ AYDP+
Sbjct: 437 VHRDSVYTAGVRGWLWVKLKRDYKSEMMDTVDLVVVGAFYGRGKRGGKLSSLLMAAYDPD 496
Query: 458 TGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKR--------VWIQPKVVIEVTYQE 509
F V KV +GFTD++L +MLK II + R VW++P +V E+ E
Sbjct: 497 RDVFPTVCKVATGFTDEELDRMNEMLKKHIIPRKHPRVESRIEPDVWVEPALVAEILGAE 556
Query: 510 IQKSPKYRS---------GFALRFPRYVALREDKGPEDADTIERIAQLYELQER 554
+ SP + G ++RFPR++ R+DK PEDA T + ++Y+ Q R
Sbjct: 557 LTLSPMHTCCLNTVRPGVGISIRFPRFIRWRDDKSPEDATTTHELLEMYKRQLR 610
>gb|AAK40535.1| DNA ligase (polydeoxyribonucleotide synthase (ATP)) (lig)
[Sulfolobus solfataricus]
Length = 601
Score = 405 bits (1030), Expect = e-112
Identities = 228/593 (38%), Positives = 355/593 (59%), Gaps = 39/593 (6%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEW-DERELG 59
M + +A+ + KLEK + +L T L+AD L K + ++ + Y+I G ++P++ ELG
Sbjct: 1 MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLWPDFLGYPELG 60
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFF--------SQPL 111
+GEK LIKA+S+AT D +EN K GDLGE +A +K ++Q + + L
Sbjct: 61 IGEKFLIKAISIATNTDENSVENLYKTIGDLGE-VARRLKSKQQSTGILGFLGTTSKESL 119
Query: 112 TIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLL 171
T+ VY TL KVA TTGEGS+D K++ LA L A+P+EAK++ R V G +R G+ + +
Sbjct: 120 TVDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAKFLVRFVEGRLRVGIGDATV 179
Query: 172 RDAISLAFN---VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQ 228
DA+++AF E++ERAY L +D G +AKI +G + L + Q+G PI+PMLA+
Sbjct: 180 LDAMAIAFGGGQSASEIIERAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAE 239
Query: 229 QAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEA 288
+ +N +E L +MGG A + KYDG R Q+HK +K+ I+SRRLEN+T P++V+ + +
Sbjct: 240 RLSNPEEILKKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKY 299
Query: 289 LKPTKAIVEGELVAIG-EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGV 347
++ + I+EGE+VAI E G PFQ ++ R +RK +I E +++ P+ + LFD++Y + V
Sbjct: 300 IEGKEFIIEGEIVAIDPESGEMRPFQELMHR-KRKSDIYEAIKEYPVNVFLFDLMYYEDV 358
Query: 348 SLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRL-- 405
RRK LE IV+ N VKIA ++ NVE+ + F+ RA+ G EG+M K +
Sbjct: 359 DYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFFYRAISEGGEGVMVKAIGK 418
Query: 406 DAVYEPGNRGKKWLKIK-----PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGE 460
DA+Y+ G RG W+K+K + +DLV++G +G+G+R + S ++ AY+P+T
Sbjct: 419 DAIYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDS 478
Query: 461 FLEVGKVGSGFTDDDLVEFTKML--------KPLIIKEEGKRVWIQPKVVIEVTYQEIQK 512
F V KV SGF+D+ L E K L P + + +W++P V E+ EI
Sbjct: 479 FESVCKVASGFSDEQLDELQKKLMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITI 538
Query: 513 SPKYR---------SGFALRFPRYVALREDKGPEDADTIERIAQLYELQERMK 556
SP + +G ++RFPR++ R+DK PEDA T + I ++Y Q + K
Sbjct: 539 SPLHTCCQDVVEKDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKKK 591
>gb|AAF61267.1|AF242877_1 (AF242877) DNA ligase [Sulfolobus shibatae]
Length = 601
Score = 403 bits (1024), Expect = e-111
Identities = 229/593 (38%), Positives = 355/593 (59%), Gaps = 39/593 (6%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEW-DERELG 59
M + +A+ + KLEK + +L T L+AD L K + ++ + Y+I G ++P++ ELG
Sbjct: 1 MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKAIIDKVVYIIQGKLWPDFLGYPELG 60
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFF--------SQPL 111
+GEK LIKA+S+AT D +EN K TGDLGE +A +K ++Q + + L
Sbjct: 61 IGEKFLIKAISIATNTDENSVENLYKSTGDLGE-VARRLKSKQQSTGILGFLGTSSKESL 119
Query: 112 TIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLL 171
T+ VY TL KVA TTGEGS+D K++ LA L A+P+EAK++ R V G +R G+ + +
Sbjct: 120 TVDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAKFLVRFVEGRLRVGIGDATV 179
Query: 172 RDAISLAFN---VKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQ 228
DA+++AF E+VERAY L +D G +AKI +G + L + ++G PI+PMLA+
Sbjct: 180 LDAMAIAFGGGQSASEIVERAYNLRADLGNIAKIIVEKGIEALKTLKPEVGIPIRPMLAE 239
Query: 229 QAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEA 288
+ +N +E L ++GG A + KYDG R Q+HK +K+ I+SRRLEN+T P++VE I +
Sbjct: 240 RLSNPEEILKKVGGSALVDYKYDGERAQIHKKSDKIFIFSRRLENITSQYPDVVEYISKY 299
Query: 289 LKPTKAIVEGELVAIG-EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGV 347
++ + I+EGE+VA+ E G FQ ++ R +RK +I E +++ P+ + LFD++Y + V
Sbjct: 300 VEGKEFIIEGEIVAVDPESGEMRAFQELMHR-KRKSDIYEAIKEYPVNVFLFDLMYYEDV 358
Query: 348 SLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRL-- 405
RRK LE IV+ N VKIA ++ NVE+ + F+ RA+ G EG+M K +
Sbjct: 359 DYTTKPLEVRRKLLESIVKPNDYVKIAHHIQVNNVEDLKSFFYRAISEGGEGVMVKAIGK 418
Query: 406 DAVYEPGNRGKKWLKIK-----PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGE 460
DA+Y+ G RG W+K+K + +DLV++G +G+G+R + S ++ AY+P+T
Sbjct: 419 DAIYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDT 478
Query: 461 FLEVGKVGSGFTDDDLVEFTKML--------KPLIIKEEGKRVWIQPKVVIEVTYQEIQK 512
F V KV SGF+D+ L E K L P + + +WI+P V E+ EI
Sbjct: 479 FESVCKVASGFSDEQLDELQKKLMEIKRDIKHPRVNSKMEPDIWIEPVYVAEIIGAEITI 538
Query: 513 SPKYR---------SGFALRFPRYVALREDKGPEDADTIERIAQLYELQERMK 556
SP + +G ++RFPR++ R+DK PEDA T + I ++Y Q + K
Sbjct: 539 SPLHTCCQDVVEKDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKKK 591
>sp|Q02093|DNLI_ACIAM DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|282682|pir||S26383 DNA ligase (ATP) (EC 6.5.1.1) -
Desulfurolobus ambivalens >gi|40786|emb|CAA45034.1|
(X63438) DNa ligase [Acidianus ambivalens]
Length = 600
Score = 400 bits (1016), Expect = e-110
Identities = 228/589 (38%), Positives = 352/589 (59%), Gaps = 39/589 (6%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEW-DERELG 59
M + +A+ + +LEK + +L T L+AD KK ++ ++ + Y+I G ++P++ ELG
Sbjct: 1 MEFKIIAEYFDRLEKISSRLQLTSLLADLFKKTDKNVIDKVVYIIQGKLWPDFLGMPELG 60
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFF---------SQP 110
+GEK LI+A+S+AT + EIE K GDLG+ +A +K+++Q + S+P
Sbjct: 61 IGEKFLIRALSIATSVSDDEIEKMYKSVGDLGQ-VAFDIKQKQQSASILAFLGAQKASKP 119
Query: 111 LTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGL 170
LT+++VY L KVA +TGEGS+D K++ LA L DA P+EAKY+ R V G +R G+ +
Sbjct: 120 LTVEKVYDDLAKVATSTGEGSRDIKIRLLAGLLKDASPLEAKYLVRFVDGRLRVGIGDAT 179
Query: 171 LRDAISLAFNVKVE---LVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLA 227
+ DA+++ F +VERAY L +D G +AKI G + L + Q G PI+PMLA
Sbjct: 180 ILDALAITFGGGQNFRPIVERAYNLRADLGNIAKILANGGIEQLKNIKPQPGIPIRPMLA 239
Query: 228 QQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKE 287
++ ++ E L ++G A + KYDG R Q+HK G+K+ I+SRRLEN+T P++ E I +
Sbjct: 240 ERLSDPAEMLSKVGNIALVDYKYDGERGQIHKAGDKIFIFSRRLENITNQYPDVAEYISK 299
Query: 288 ALKPTKAIVEGELVAIG-EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDG 346
+K + IVEGE++ + E G PFQ ++ R +RK +I E +++ P+ + LFD++Y +G
Sbjct: 300 YVKGNEFIVEGEIIPVDPETGEMRPFQELMHR-KRKSDIHEAIKEYPVNVFLFDLMYYEG 358
Query: 347 VSLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRL- 405
ERRKKLE IVE N V IA ++IT NVE+ ++F+ +A+ G EG+M K L
Sbjct: 359 EDYTVKPLSERRKKLESIVEDNDYVHIATHIITDNVEKLKEFFYQAISEGAEGVMVKSLA 418
Query: 406 -DAVYEPGNRGKKWLKIK-----PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETG 459
DA+Y+ G+RG W+K K + +DLV++GA G+GR+ SF++ AY+P+
Sbjct: 419 PDAIYQAGSRGWLWIKFKRDYQSEMADTVDLVMVGAFHGKGRKGGKYSSFLMAAYNPDKD 478
Query: 460 EFLEVGKVGSGFTDDDLVEFTKML--------KPLIIKEEGKRVWIQPKVVIEVTYQEIQ 511
F V KV SGFTD +L + K + P ++ VW+ P +V E+ EI
Sbjct: 479 VFETVCKVASGFTDAELDDLQKKIAELKRDTPHPRVVSTMVPDVWLTPALVAEIIGAEIT 538
Query: 512 KSPKY--------RSGFALRFPRYVALREDKGPEDADTIERIAQLYELQ 552
SP + G ++RFPR++ R DK PEDA T I ++Y+ Q
Sbjct: 539 ISPLHTCCKDQYAEGGLSIRFPRFIRWRPDKSPEDATTNREILEMYKSQ 587
>pir||D70421 DNA ligase (ATP dependent) - Aquifex aeolicus
>gi|2983805|gb|AAC07362.1| (AE000738) DNA ligase (ATP
dependent) [Aquifex aeolicus]
Length = 585
Score = 382 bits (971), Expect = e-105
Identities = 217/587 (36%), Positives = 347/587 (58%), Gaps = 37/587 (6%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
M Y LA+ Y+++EKTT ++ + + K+ P++ ++ + YL +G + PE+ +
Sbjct: 2 MEYRILAEFYERIEKTTSRIEMVSSLVELFKQTPKELIDKVVYLSIGKIAPEYTGLDYNF 61
Query: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQP--LTIKRVYQ 118
GEKL I+A+S I + EIE V+ GDLGE A +K ++ F LT++ VY
Sbjct: 62 GEKLAIRALSRVLKIPALEIEKRVRQEGDLGE----AGRKLYEELGFKPEGTLTVEEVYN 117
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
L+ +A+ G GSQ++K+ A+L A P+EAKY+ RT+ +R G+ + + +A+S+A
Sbjct: 118 GLLNIAKAVGIGSQERKISIFASLLKKATPLEAKYLLRTITERLRLGIGDNTILEALSIA 177
Query: 179 F---NVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKE 235
F +V E+VERAY LTSD G+VAKI +G +G+ +V IQ+G+P++PMLA++ ++
Sbjct: 178 FTGSSVNREVVERAYNLTSDLGYVAKILAEKGLEGVKQVKIQVGRPVRPMLAERMSSPIL 237
Query: 236 ALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAI 295
L ++GG+ E KYDG R+Q H+ G++ ++SRRLEN+T P+++E +KEA+ P I
Sbjct: 238 ILRKLGGKCGAEYKYDGERIQAHRKGDEFYLFSRRLENITHQYPDLIEFLKEAI-PHDFI 296
Query: 296 VEGELVAIG-EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKF 354
VE E V I G PFQ ++ R + KY + + K P+ LFD++Y+DG L +
Sbjct: 297 VELEAVVIDPASGEIRPFQELMHR-KVKYVTKYHITKYPVAGFLFDIIYLDGEDLTLKPY 355
Query: 355 MERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRL--DAVYEPG 412
ERR+ LE++V+ ++ + I NVE+ E F+ +A+E G EGL+ K L +++Y+ G
Sbjct: 356 PERREILEKVVKRTDRIGLVPRKIVDNVEDLENFFYQAIEEGCEGLVCKSLAPNSIYQAG 415
Query: 413 NRGKKWLKIK-----PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKV 467
RG W+K K + LDLV++G +G+G+R GS ++ YDPE+ F V KV
Sbjct: 416 KRGFLWIKYKRDYKSVLADTLDLVVVGGFYGKGQRKGTFGSLLMACYDPESDMFKTVTKV 475
Query: 468 GSGFTDDDLVEFTKMLKPLIIKEEGKRV--------WIQPKVVIEVTYQEIQKSPKY--- 516
G+GFT+DD + ++L P + RV W +P +V+E+T E+ SP +
Sbjct: 476 GTGFTEDDFKKLEEILMPRKLNHRHPRVNSILEADMWFEPYLVLEITGAELTLSPVHTCG 535
Query: 517 ------RSGFALRFPRYVA-LREDKGPEDADTIERIAQLYELQERMK 556
G LRFPR+ R DK PEDA T + I ++Y +Q +++
Sbjct: 536 WGKVSPNRGIGLRFPRFTGRYRFDKRPEDATTEQEIIEMYRMQRKIR 582
>emb|CAC12273.1| (AL445066) DNA ligase related protein [Thermoplasma acidophilum]
Length = 588
Score = 334 bits (848), Expect = 1e-90
Identities = 200/582 (34%), Positives = 317/582 (54%), Gaps = 29/582 (4%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGV 60
M + +A ++K+E TT +L T L+ + LK+ +D L + YL+ G + P++ E +
Sbjct: 1 MLFSVVADAFEKMESTTKRLELTDLLVNLLKEADDD-LPLLIYLLEGKLGPDYLGIETQM 59
Query: 61 GEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTL 120
+KL+IKA+S+A+ I EI GD+G +KR +S + +T+K ++ TL
Sbjct: 60 SDKLIIKALSVASNISEDEIAKEYAKAGDIGTIAKEIAEKRSLRSLVQEEMTVKYIHDTL 119
Query: 121 VKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAF- 179
+K+A TTG GS ++ +LF+++ P E YI R + G +R G+++ + DAI AF
Sbjct: 120 MKMARTTGSGSTKARVDAYMDLFLNSTPKEIMYITRIITGKLRIGISDATILDAIVKAFA 179
Query: 180 -NVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALL 238
E +E A+ D G++A + D + K+ P K MLA++ +++E L
Sbjct: 180 DEKYSEDIENAFNFHPDLGYIASELRKGNIDAILKLGPTPMIPFKVMLAERLRSVEEILE 239
Query: 239 EMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEG 298
+MGG FE KYDG R + H + KV ++SR E T P+I +A E K AI++G
Sbjct: 240 KMGGRCAFEYKYDGMRTETHIERGKVRLFSRGNEETTNQFPDITKAASETFKVDSAILDG 299
Query: 299 ELVAIGED-GRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMER 357
E V D G PFQ + R RKY+++++ +IP+ + LFD++Y++G L T + ER
Sbjct: 300 EAVPYDPDTGELYPFQVISHRRGRKYDLDKVSSEIPITVFLFDIVYLNGRDLSKTPYTER 359
Query: 358 RKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRL--DAVYEPGNRG 415
RK LE I + ++A+ + + + E +F+ A+E G EGL+AK D+ Y+ G RG
Sbjct: 360 RKILESIFTESDSFRLAKRIESGDPAEVHRFFNSAIEDGCEGLVAKSTSPDSFYKAGARG 419
Query: 416 KKWLKIK-----PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSG 470
W+K+K + LDL ++GA +G GRR G+ +L Y+ + F V K+GSG
Sbjct: 420 WLWIKLKRDYQAQLWDTLDLTVVGAFYGHGRRKGTYGALLLATYNDKNDTFETVCKLGSG 479
Query: 471 FTDDDLVEFTKMLKPLIIKEEGKR--------VWIQPKVVIEVTYQEIQKSPKYR----- 517
F+DD L K + + KE+ R VW P VV+EV EI SP +
Sbjct: 480 FSDDVLFSLPKKFEQYVSKEKPARVISNLEPDVWFYPAVVMEVIGAEITVSPIHTCAYGE 539
Query: 518 ----SGFALRFPRYVA-LREDKGPEDADTIERIAQLYELQER 554
SG ++RFPR+ REDK PED+ T I ++Y+ Q++
Sbjct: 540 IEKDSGLSVRFPRFTGKWREDKKPEDSTTSREILEMYKEQKK 581
>pir||G70649 probable DNA ligase - Mycobacterium tuberculosis (strain H37RV)
>gi|1781151|emb|CAB06260.1| (Z83866) ligB [Mycobacterium
tuberculosis]
Length = 507
Score = 286 bits (724), Expect = 5e-76
Identities = 170/440 (38%), Positives = 241/440 (54%), Gaps = 8/440 (1%)
Query: 111 LTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGL 170
LT+ V TL K+ G+GSQ ++ +A LF A E ++ R + G +R G G+
Sbjct: 75 LTVTGVDATLSKIGTLPGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGI 134
Query: 171 LRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQA 230
+ DA++ A + V+RA ML D A A L T+++G+PI PMLAQ A
Sbjct: 135 MADAVAQAAGLPAATVQRAAMLGGDLAAAA--AAGLSGAALDTFTLRVGRPIGPMLAQTA 192
Query: 231 ANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALK 290
++ +AL GG FE K DGARVQ+H+ ++V IY+R L++VT +PE+VEA AL
Sbjct: 193 TSVHDALERHGGTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATL-ALP 251
Query: 291 PTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLI 350
+ +GE +A+ D RP FQ RF R ++ PL + FD+L+ DG L+
Sbjct: 252 VRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLL 311
Query: 351 DTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYE 410
+ ER L+ +V +V + LIT + +A F L GHEG+MAK A Y
Sbjct: 312 EAPTTERLAALDALVPARHRV---DRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYL 368
Query: 411 PGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSG 470
G RG WLK+KP + LDLV++ EWG GRR L + LGA DP TG F+ VGK G
Sbjct: 369 AGRRGAGWLKVKP-VHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKG 427
Query: 471 FTDDDL-VEFTKMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVA 529
TD L + T+ + + +G V ++P+ V+EV +Q+S +Y G ALRF R V
Sbjct: 428 MTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVR 487
Query: 530 LREDKGPEDADTIERIAQLY 549
R DK P +ADTI+ + LY
Sbjct: 488 YRADKDPAEADTIDAVRALY 507
>gi|6320038 DNA ligase; Cdc9p [Saccharomyces cerevisiae]
>gi|2506361|sp|P04819|DNLI_YEAST DNA LIGASE I,
MITOCHONDRIAL PRECURSOR (POLYDEOXYRIBONUCLEOTIDE
SYNTHASE [ATP]) >gi|2144570|pir||LQBYPX DNA ligase (ATP)
(EC 6.5.1.1) [validated] - yeast (Saccharomyces
cerevisiae) >gi|1061275|emb|CAA91582.1| (Z67750) DNA
ligase [Saccharomyces cerevisiae]
>gi|1431259|emb|CAA98737.1| (Z74212) ORF YDL164c
[Saccharomyces cerevisiae]
Length = 755
Score = 282 bits (714), Expect = 7e-75
Identities = 202/611 (33%), Positives = 317/611 (51%), Gaps = 61/611 (9%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV-PEDHLEFIP--YLILGDVFPEWDER-EL 58
Y E+ +++ K+E + +L R+ +DF K+ + IP YL + + P+++ EL
Sbjct: 148 YSEVCEVFNKIEAISSRLEIIRICSDFFIKIMKQSSKNLIPTTYLFINRLGPDYEAGLEL 207
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
G+GE LL+K +S G +I+ KD GDLGE IA+ + + F +PLT+ V++
Sbjct: 208 GLGENLLMKTISETCGKSMSQIKLKYKDIGDLGE-IAMGARNVQPTMFKPKPLTVGEVFK 266
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
L +A+T G+ SQ KKMK + + + IEAK++ R++ +R G+AE + ++S A
Sbjct: 267 NLRAIAKTQGKDSQLKKMKLIKRMLTACKGIEAKFLIRSLESKLRIGLAEKTVLISLSKA 326
Query: 179 F-------------NVKVELVERAYMLTSD-------FGFVAKIAKTEGNDGLAKV-TIQ 217
+V ++++E A D + V G L K T++
Sbjct: 327 LLLHDENREDSPDKDVPMDVLESAQQKIRDAFCQVPNYEIVINSCLEHGIMNLDKYCTLR 386
Query: 218 IGKPIKPMLAQQAANIKEALLEMGGEA-EFEIKYDGARVQVH--KDGEKVTIYSRRLENV 274
G P+KPMLA+ I E L GE E KYDG R QVH DG + IYSR EN+
Sbjct: 387 PGIPLKPMLAKPTKAINEVLDRFQGETFTSEYKYDGERAQVHLLNDGT-MRIYSRNGENM 445
Query: 275 TRAIPEI--VEAIKEALKPTKAIVEGELVAIGED-GRPLPFQYVLRRFRRKYNIEEMMEK 331
T PEI + I++ I++ E VA +D G+ LPFQ + R R+ + ++ K
Sbjct: 446 TERYPEINITDFIQDLDTTKNLILDCEAVAWDKDQGKILPFQVLSTRKRKDVELNDV--K 503
Query: 332 IPLELNLFDVLYVDGVSLIDTKFMERRKKLEEIVET-NGKVKIAENLITKNVEEAEQFYK 390
+ + L FD+L + LI+ ERR+ L ++ + G+ + A + T N++E ++F
Sbjct: 504 VKVCLFAFDILCYNDERLINKSLKERREYLTKVTKVVPGEFQYATQITTNNLDELQKFLD 563
Query: 391 RALEMGHEGLMAKRLDAV---YEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRR 442
++ EGLM K L+ YEP R + WLK+K ++LDL ++GA +G G+R
Sbjct: 564 ESVNHSCEGLMVKMLEGPESHYEPSKRSRNWLKLKKDYLEGVGDSLDLCVLGAYYGRGKR 623
Query: 443 AHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII----------KEEG 492
G F+LG Y+ +TGEF K+G+GF+D+ L L P II
Sbjct: 624 TGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQLLHDRLTPTIIDGPKATFVFDSSAE 683
Query: 493 KRVWIQPKVVIEVTYQEIQKSPKYRSGFA-------LRFPRYVALREDKGPEDADTIERI 545
VW +P + EV ++ SP Y++G A LRFPR++ +REDKG EDA + ++I
Sbjct: 684 PDVWFEPTTLFEVLTADLSLSPIYKAGSATFDKGVSLRFPRFLRIREDKGVEDATSSDQI 743
Query: 546 AQLYELQERMK 556
+LYE Q M+
Sbjct: 744 VELYENQSHMQ 754
>emb|CAA27005.1| (X03246) put. DNA ligase (CDC9) (aa 1-755) [Saccharomyces
cerevisiae]
Length = 755
Score = 282 bits (713), Expect = 9e-75
Identities = 202/611 (33%), Positives = 317/611 (51%), Gaps = 61/611 (9%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV-PEDHLEFIP--YLILGDVFPEWDER-EL 58
Y E+ +++ K+E + +L R+ +DF K+ + IP YL + + P+++ EL
Sbjct: 148 YSEVCEVFNKIEAISSRLEIIRICSDFFIKIMKQSSKNVIPTTYLFINRLGPDYEAGLEL 207
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
G+GE LL+K +S G +I+ KD GDLGE IA+ + + F +PLT+ V++
Sbjct: 208 GLGENLLMKTISETCGKSMSQIKLKYKDIGDLGE-IAMGARNVQPTMFKPKPLTVGEVFK 266
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
L +A+T G+ SQ KKMK + + + IEAK++ R++ +R G+AE + ++S A
Sbjct: 267 NLRAIAKTQGKDSQLKKMKLIKRMLTACKGIEAKFLIRSLESKLRIGLAEKTVLISLSKA 326
Query: 179 F-------------NVKVELVERAYMLTSD-------FGFVAKIAKTEGNDGLAKV-TIQ 217
+V ++++E A D + V G L K T++
Sbjct: 327 LLLHDENREDSPDKDVPMDVLESAQQKIRDAFCQVPNYEIVINSCLEHGIMNLDKYCTLR 386
Query: 218 IGKPIKPMLAQQAANIKEALLEMGGEA-EFEIKYDGARVQVH--KDGEKVTIYSRRLENV 274
G P+KPMLA+ I E L GE E KYDG R QVH DG + IYSR EN+
Sbjct: 387 PGIPLKPMLAKPTKAINEVLDRFQGETFTSEYKYDGERAQVHLLNDGT-MRIYSRNGENM 445
Query: 275 TRAIPEI--VEAIKEALKPTKAIVEGELVAIGED-GRPLPFQYVLRRFRRKYNIEEMMEK 331
T PEI + I++ I++ E VA +D G+ LPFQ + R R+ + ++ K
Sbjct: 446 TERYPEINITDFIQDLDTTKNLILDCEAVAWDKDQGKILPFQVLSTRKRKDVELNDV--K 503
Query: 332 IPLELNLFDVLYVDGVSLIDTKFMERRKKLEEIVET-NGKVKIAENLITKNVEEAEQFYK 390
+ + L FD+L + LI+ ERR+ L ++ + G+ + A + T N++E ++F
Sbjct: 504 VKVCLFAFDILCYNDERLINKSLKERREYLTKVTKVVPGEFQYATQITTNNLDELQKFLD 563
Query: 391 RALEMGHEGLMAKRLDAV---YEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRR 442
++ EGLM K L+ YEP R + WLK+K ++LDL ++GA +G G+R
Sbjct: 564 ESVNHSCEGLMVKMLEGPESHYEPSKRSRNWLKLKKDYLEGVGDSLDLCVLGAYYGRGKR 623
Query: 443 AHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII----------KEEG 492
G F+LG Y+ +TGEF K+G+GF+D+ L L P II
Sbjct: 624 TGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQLLHDRLTPTIIDGPKATFVFDSSAE 683
Query: 493 KRVWIQPKVVIEVTYQEIQKSPKYRSGFA-------LRFPRYVALREDKGPEDADTIERI 545
VW +P + EV ++ SP Y++G A LRFPR++ +REDKG EDA + ++I
Sbjct: 684 PDVWFEPTTLFEVLTADLSLSPIYKAGSATFDKGVSLRFPRFLRIREDKGVEDATSSDQI 743
Query: 546 AQLYELQERMK 556
+LYE Q M+
Sbjct: 744 VELYENQSHMQ 754
>emb|CAC01484.1| (AL391017) putative DNA ligase [Streptomyces coelicolor A3(2)]
Length = 512
Score = 277 bits (701), Expect = 2e-73
Identities = 179/546 (32%), Positives = 277/546 (49%), Gaps = 44/546 (8%)
Query: 1 MRYIELAQLYQKLEKTTMKLIKTRLVADFLKKVPE-DHLEFIPYLILGDVFPEWDERELG 59
M LAQ+ +++ T+ + KT L+A+ ++ D IPYL + +G
Sbjct: 1 MLLARLAQVSREVAATSARSRKTVLLAELFREAEAADVPVVIPYLA-----GRLPQGRIG 55
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQT 119
VG K+L + V A + LT++ V
Sbjct: 56 VGWKVLSRRVPPAD----------------------------------APTLTVRDVDAR 81
Query: 120 LVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAF 179
L ++ +G GSQ ++ + + L A E +++ + G +R G + + ++ A
Sbjct: 82 LTRLGAVSGAGSQAERTRLVGELMGAATEDEQRFLIGLLTGEVRQGALDAAAVEGLAAAT 141
Query: 180 NVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLE 239
+ V RA ML VA+ +G L + + +G+P+ PMLA A+++ EA+ +
Sbjct: 142 DAPPADVRRAVMLAGSLQTVAEALLADGPGALDRFRLTVGQPVLPMLAHSASSVAEAVGK 201
Query: 240 MGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGE 299
+G A E K DG RVQVH+DG V IY+R L+++T +PE+ EA AL + I++GE
Sbjct: 202 LGAAA-VEEKLDGIRVQVHRDGGTVRIYTRTLDDITDRLPEVTEAAL-ALPGERFILDGE 259
Query: 300 LVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRK 359
+++ DGRP FQ R + ++ +P+ FDVL VDG L+D ER
Sbjct: 260 AISLDADGRPRSFQETAGRVGSRTDVATAARAVPVSAVFFDVLSVDGRDLLDLPLTERHA 319
Query: 360 KLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWL 419
+L +V +V+ ++ AE+F R L GHEG++ K LDA Y G RG WL
Sbjct: 320 ELARLVPEPLRVRRTLVHGPEDTGAAEEFLARTLARGHEGVVVKGLDAAYSAGRRGASWL 379
Query: 420 KIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEF 479
K+KP + LDLV++ AEWG GRR L + LGA + G F +GK G TD L
Sbjct: 380 KVKP-VHTLDLVVLAAEWGHGRRTGKLSNLHLGARTAD-GSFAMLGKTFKGMTDALLTWQ 437
Query: 480 TKMLKPLIIKEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDA 539
T+ LK L ++E G V ++P++V+E+ Y +Q+S +Y +G LRF R V REDK PEDA
Sbjct: 438 TERLKELAVEEHGWGVTVRPELVVEIAYDGLQRSTRYPAGVTLRFARVVRYREDKRPEDA 497
Query: 540 DTIERI 545
DT++ +
Sbjct: 498 DTVDTL 503
>sp|P51892|DNL1_XENLA DNA LIGASE I (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|2118374|pir||JC4852 DNA ligase (ATP) (EC 6.5.1.1) I -
African clawed frog >gi|1161304|gb|AAB37754.1| (L43496)
ligase I [Xenopus laevis]
Length = 1070
Score = 274 bits (694), Expect = 2e-72
Identities = 196/623 (31%), Positives = 319/623 (50%), Gaps = 76/623 (12%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
Y+ +A+ ++++E+ + +L +++FL+ V PED L I YL L + P ++ EL
Sbjct: 442 YLAVARTFERIEEESARLKNVETLSNFLRSVIALTPEDLLPCI-YLCLNRLGPAYEGLEL 500
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQP-LTIKRVY 117
G+GE +L+KAV+ ATG ++I+ ++ GDLG + + Q++ F+ P L V+
Sbjct: 501 GIGETILMKAVAQATGRQLEKIKAEAQEKGDLG--LVAESSRSNQRTMFTPPKLMASGVF 558
Query: 118 QTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAE--------- 168
L +A TG S +KK+ + LF+ EA+YIAR++ G +R G+AE
Sbjct: 559 GKLKDIARMTGNASMNKKIDIIKGLFVACRHSEARYIARSLGGKLRIGLAEQSVLSSIAQ 618
Query: 169 --------------------GLLRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGN 208
G+ DA K ++++ + ++ + I G
Sbjct: 619 AVCLTPPGRDAPPTVMDAGKGMSADARKSWIEEKAMILKQTFCELPNYDAIIPILLEHGI 678
Query: 209 DGLAK-VTIQIGKPIKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVH--KDGEK 263
D L K + G P+KPMLA I E L EA F E KYDG R Q+H ++GE
Sbjct: 679 DDLPKHCRLTPGIPLKPMLAHPTKGIGEVLKRFD-EAAFTCEYKYDGERAQIHILENGE- 736
Query: 264 VTIYSRRLENVTRAIPEIVEAIKEALKPT--KAIVEGELVAIGEDGRPL-PFQYVLRRFR 320
V +YSR EN T P+I+ I + K + I++ E VA + + + PFQ + R R
Sbjct: 737 VHVYSRNQENNTTKYPDIISRIPKIKKESVKSCILDTEAVAGDAEKKQIQPFQVLTTRKR 796
Query: 321 RKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEE-IVETNGKVKIAENLIT 379
+ + E+ K+ + + FD+LY++G SL+ F +RR+ L + +ET G+ A +
Sbjct: 797 KDVDASEI--KVQVCVYAFDMLYLNGESLVKEPFAKRRQLLRDSFLETEGQFMFATYMDK 854
Query: 380 KNVEEAEQFYKRALEMGHEGLMAKRL--DAVYEPGNRGKKWLKIKPTM-----ENLDLVI 432
N +E +F ++++ EGLM K L DA YE R WLK+K + LDLV+
Sbjct: 855 SNTDEISEFLDQSIKDSCEGLMVKTLEQDATYEIAKRSHNWLKLKKDYLEGVGDTLDLVV 914
Query: 433 IGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEG 492
IGA G+G+R + G F+L +YD E+ E+ + K+G+GFTDDDL + LK +I+
Sbjct: 915 IGAYLGKGKRTGIYGGFLLASYDEESEEYQTICKIGTGFTDDDLEKHYNFLKDHVIENPR 974
Query: 493 KRV----------WIQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALRED 533
W P V EV ++ SP +++ G +LRFPR++ +R+D
Sbjct: 975 SYYRWDSATEPDHWFDPVQVWEVKCADLSISPVHKAALGLVEDQKGISLRFPRFLRIRDD 1034
Query: 534 KGPEDADTIERIAQLYELQERMK 556
K PE++ ++A LY Q++++
Sbjct: 1035 KKPEESTNSFQVADLYRKQQQIQ 1057
>gb|AAF47090.1| (AE003462) CG5602 gene product [Drosophila melanogaster]
Length = 692
Score = 271 bits (685), Expect = 2e-71
Identities = 186/613 (30%), Positives = 318/613 (51%), Gaps = 67/613 (10%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
Y+ LA+ +Q +E+T +L +++F V PED + + YL + + P ++ EL
Sbjct: 72 YLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSV-YLSINQLAPAYEGLEL 130
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
GV E L+KA+ ATG + I++ + TGDLG +A + ++ F PL ++ V++
Sbjct: 131 GVAETTLMKAICKATGRNLAHIKSQTQLTGDLG-IVAEQSRVSQRMMFQPAPLNVRDVFR 189
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
L ++A+ +G+ KM + N+F+ EA++ R+++G +R G+AE L A+++
Sbjct: 190 KLREIAKLSGQS----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTALAIG 245
Query: 179 FN----------------VKVELVERAYMLTSDFG-------FVAKIAKTEGNDGLAKVT 215
K E+V+ +L + + + I K + + +
Sbjct: 246 LVKKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERCP 305
Query: 216 IQIGKPIKPMLAQQAANIKEALLEMGG-EAEFEIKYDGARVQVHKDGE-KVTIYSRRLEN 273
+ G P++PMLAQ + E GG + E KYDG R Q+H++ + +++I+SR EN
Sbjct: 306 MHPGMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSEN 365
Query: 274 VTRAIPEIVEAIKEALKPT--KAIVEGELVAIGEDGRP-LPFQYVLRRFRRKYNIEEMME 330
T P+++ LK I++ E+VA + + LPFQ + R R+ +IEE+
Sbjct: 366 NTAKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEI-- 423
Query: 331 KIPLELNLFDVLYVDGVSLIDTKFMERRKKL-EEIVETNGKVKIAENLITKNVEEAEQFY 389
K+ + + +FD+LY++G +L+ ERRK L E E G+ K A L T +++E +QF
Sbjct: 424 KVQVCVYIFDLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFL 483
Query: 390 KRALEMGHEGLMAKRLD--AVYEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRR 442
+ +++ EGLM K LD A YE R + WLK+K ++LDLV+IG G+GRR
Sbjct: 484 EESIKGNCEGLMVKTLDEEATYEIAKRSRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRR 543
Query: 443 AHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKRV------- 495
G F+L YD E E+ + K+G+GFTD+DL ++ L +
Sbjct: 544 TGTYGGFLLACYDTENEEYQSICKIGTGFTDEDLQTHSEFLGKHVTSAAKSYYRYDPSLE 603
Query: 496 ---WIQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALREDKGPEDADTIE 543
W +P V EV ++ SP +R+ G +LRFPR++ +R+DK E+A
Sbjct: 604 PDHWFEPVQVWEVKCADLSLSPIHRAAIGIVDGERGISLRFPRFIRIRDDKNSENATDAN 663
Query: 544 RIAQLYELQERMK 556
++A +Y+ Q+++K
Sbjct: 664 QVAHMYQSQDQVK 676
>sp|Q27474|DNLI_CAEEL PROBABLE DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|7496656|pir||T19544 hypothetical protein C29A12.3 -
Caenorhabditis elegans >gi|3874600|emb|CAA98242.1|
(Z73970) predicted using Genefinder~Similarity to Mouse
DNA ligase I (SW:DNL1_MOUSE), contains similarity to
Pfam domain: PF01068 (DNA ligase), Score=647.7,
E-value=2e-191, N=1~cDNA EST yk320h11.3 comes from this
gene~cDNA EST yk320h11.5 comes from thi>
Length = 847
Score = 270 bits (682), Expect = 4e-71
Identities = 195/608 (32%), Positives = 310/608 (50%), Gaps = 65/608 (10%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKVPE---DHLEFIPYLILGDVFPEWDERELG 59
Y E A +K+E+ + K K +A F KV + D L Y+ + + P ++ ELG
Sbjct: 95 YKEFALTLEKIEELSGKK-KVDELAQFFTKVLDFSPDDLTACVYMSVNQLGPSYEGLELG 153
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQP--LTIKRVY 117
V E LIKAV+ ATG +I+ ++ GDLG +A + R + + P LT+ V+
Sbjct: 154 VAENSLIKAVAKATGRTEGKIKEDLRAKGDLG---TVAQQSRSNQKMLAVPKALTVPTVF 210
Query: 118 QTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISL 177
L ++A+ +G + +KK+ ++ L + + IEA+++ R + G MR G+ E + A+
Sbjct: 211 NKLTEIAKLSGTSAMNKKVDAISALLIACQGIEARFLVRMLAGKMRIGLGEQSVLSALGH 270
Query: 178 AFNVK-------------------VELVERAYMLTSDFGFVAKIAKTEGNDGLA-KVTIQ 217
AF + V+ V+ AY ++ + ++A TEG + L K +
Sbjct: 271 AFTLSKITDQKVRGDKLDSLKDANVKRVKTAYCECPNYNRLIEVALTEGVEALVEKCKLS 330
Query: 218 IGKPIKPMLAQQAANIKEALLEMGGEA-EFEIKYDGARVQVHK--DGEKVTIYSRRLENV 274
G P+KPMLA I E + + E KYDG R Q+HK DG+ + IYSR EN
Sbjct: 331 PGIPLKPMLAHPTKGIDEIMRRFRNQTMTCEWKYDGERGQIHKREDGQ-IFIYSRNQENN 389
Query: 275 TRAIPEIVEAIKEALKP--TKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKI 332
T P+I+E I + T IV+ E+VAI E G LPFQ + R R+ + ++ +
Sbjct: 390 TTKYPDIIEKISSCIGDGVTSFIVDAEVVAIDEAGLILPFQVLSTRKRKNATDDNGVKVV 449
Query: 333 PLELNLFDVLYVDGVSLIDTKFMERRKKLE-EIVETNGKVKIAENLITKNVEEAEQFYKR 391
LFD+LY +G L+ +RR+ L + +G A ++ T + +E F+
Sbjct: 450 VF---LFDLLYFNGEPLVRKPLRKRRELLRTNFKKIDGSFYFATSVDTNDTDEINSFFDE 506
Query: 392 ALEMGHEGLMAKRLD--AVYEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRRAH 444
A++ EGLM K LD A YE R WLK+K + LDLV++GA G G+R
Sbjct: 507 AVQNKCEGLMIKTLDTEATYEISRRSHSWLKMKKDYVDGVGDTLDLVVMGAYSGVGKRTG 566
Query: 445 LLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKRV--------- 495
+ G ++LG Y+P T E+ V K+G+GFTD+DL E K+L+ I +
Sbjct: 567 VYGGYLLGCYNPTTEEYESVCKIGTGFTDEDLAEQYKILQDKKIDKSPSYYQFDHTLKPD 626
Query: 496 -WIQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALREDKGPEDADTIERI 545
P +V EV +I SP++++ G +LRFPR++ +R+DK +DA + E++
Sbjct: 627 DTFSPYLVFEVKCADITISPRHKAASGLTDDGKGISLRFPRFLRIRDDKNSDDATSSEQV 686
Query: 546 AQLYELQE 553
++Y+ QE
Sbjct: 687 LEMYKNQE 694
>gi|6754544 ligase I, DNA, ATP-dependent [Mus musculus]
>gi|1352290|sp|P37913|DNL1_MOUSE DNA LIGASE I
(POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|2118373|pir||I48921 DNA ligase (ATP) (EC 6.5.1.1) I
- mouse >gi|641912|gb|AAB60500.1| (U19604) DNA ligase I
[Mus musculus] >gi|905354|gb|AAA70403.1| (U04674) DNA
ligase I [Mus musculus]
Length = 916
Score = 269 bits (681), Expect = 5e-71
Identities = 197/623 (31%), Positives = 315/623 (49%), Gaps = 72/623 (11%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
++ +A+ ++K+E+ + +L +++ L+ V P D L + YL L + P EL
Sbjct: 287 FLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPPDLLPVL-YLSLNRLGPPQQGLEL 345
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
GVG+ +L+KAV+ ATG + I V + GD+G +A + ++ PLTI V+
Sbjct: 346 GVGDGVLLKAVAQATGRQLESIRAEVAEKGDVG-LVAENSRSTQRLMLPPPPLTISGVFT 404
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
+A TG S KKM + LF+ EA+YIAR++ G +R G+AE + A++ A
Sbjct: 405 KFCDIARLTGSASMAKKMDIIKGLFVACRHSEARYIARSLSGRLRLGLAEQSVLAALAQA 464
Query: 179 FNV---------------KVELVERAYMLTSDFGFVAKIAKTEGND-----------GLA 212
++ K + E M + G + K E D GL
Sbjct: 465 VSLTPPGQEFPTVVVDAGKGKTAEARKMWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLE 524
Query: 213 KVT----IQIGKPIKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVHK-DGEKVT 265
++ + G P+KPMLA + E L E +F E KYDG R Q+H +G +V
Sbjct: 525 RLPEHCKLSPGVPLKPMLAHPTRGVSEVLKRFE-EVDFTCEYKYDGQRAQIHVLEGGEVK 583
Query: 266 IYSRRLENVTRAIPEIVEAIKEALKP--TKAIVEGELVAIGEDGRPL-PFQYVLRRFRRK 322
I+SR E+ T P+I+ I + P T I++ E VA + + + PFQ + R R++
Sbjct: 584 IFSRNQEDNTGKYPDIISRIPKIKHPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKE 643
Query: 323 YNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEE-IVETNGKVKIAENLITKN 381
+ E+ ++ + L FD++Y++G SL+ RR+ L E VET G+ +L TK+
Sbjct: 644 VDASEI--QVQVCLYAFDLIYLNGESLVRQPLSRRRQLLRENFVETEGEFVFTTSLDTKD 701
Query: 382 VEEAEQFYKRALEMGHEGLMAKRLD--AVYEPGNRGKKWLKIKPTM-----ENLDLVIIG 434
E+ +F +++++ EGLM K LD A YE R WLK+K + LDLV+IG
Sbjct: 702 TEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIG 761
Query: 435 AEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKR 494
A G G+RA G F+L AYD E+ E + K+G+GF+D++L E + L+ L++
Sbjct: 762 AYLGRGKRAGRYGGFLLAAYDEESEELQAICKLGTGFSDEELEEHHQSLQALVLPTPRPY 821
Query: 495 V----------WIQPKVVIEVTYQEIQKSPKY---------RSGFALRFPRYVALREDKG 535
V W+ P +V EV ++ SP Y G +LRFPR++ +R+DK
Sbjct: 822 VRIDGAVAPDHWLDPSIVWEVKCADLSLSPIYPAARGLVDKEKGISLRFPRFIRVRKDKQ 881
Query: 536 PEDADTIERIAQLYELQERMKGK 558
PE A T ++A LY Q +++ +
Sbjct: 882 PEQATTSNQVASLYRKQSQIQNQ 904
>gb|AAF82585.1|AF276774_1 (AF276774) DNA ligase I [Rattus norvegicus]
Length = 918
Score = 265 bits (671), Expect = 7e-70
Identities = 195/623 (31%), Positives = 318/623 (50%), Gaps = 72/623 (11%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
++ +A+ ++K+E+ + +L +++ L+ V P D L + YL L + P EL
Sbjct: 289 FLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPTDLLPVL-YLSLNRLGPPQQGLEL 347
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
GVG+ +L+KAV+ ATG + I V + GD+G +A + ++ S PLT+ V+
Sbjct: 348 GVGDGVLLKAVAQATGRQLESIRAEVAEKGDVG-LVAENSRSTQRLMLPSPPLTVSGVFT 406
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
+A TG S KKM + LF+ EA++IAR++ G +R G+AE + A++ A
Sbjct: 407 KFCDIARLTGSASMAKKMDIIKGLFVACRYSEARFIARSLSGRLRLGLAEQSVLAALAQA 466
Query: 179 FNV---------------KVELVERAYMLTSDFGFVAKIAKTEGND-----------GLA 212
++ K + E M + G + K E D GL
Sbjct: 467 GSLTPPGQEFPTVVVDAGKGKTAEARKMWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLE 526
Query: 213 KVT----IQIGKPIKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVHK-DGEKVT 265
+ + G P+KPMLA ++E L E +F E KY G R Q+H +G +V
Sbjct: 527 SLPEHCKLSPGVPLKPMLAHPTRGVREVLKRFE-EVDFTCEYKYYGQRAQIHVLEGGEVK 585
Query: 266 IYSRRLENVTRAIPEIVEAIKEALKP--TKAIVEGELVAIGEDGRPL-PFQYVLRRFRRK 322
I+SR E+ + P+I+ I + P T I++ E VA + + + PFQ + R R++
Sbjct: 586 IFSRNQEDNSGKYPDIISRIPKIKHPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKE 645
Query: 323 YNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEE-IVETNGKVKIAENLITKN 381
+ E+ ++ + L FD++Y++G SL RR+ L E VET G+ A +L TK+
Sbjct: 646 VDASEI--QVQVCLYAFDLIYLNGESLARQPLSRRRQLLRENFVETEGEFVFATSLDTKD 703
Query: 382 VEEAEQFYKRALEMGHEGLMAKRLD--AVYEPGNRGKKWLKIKPTM-----ENLDLVIIG 434
+E+ +F +++++ EGLM K LD A YE R WLK+K + LDLV+IG
Sbjct: 704 IEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLEGVGDTLDLVVIG 763
Query: 435 AEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKR 494
A G G+R G F+L AYD E+ E + K+G+GF+D++L E + ++ L++
Sbjct: 764 AYLGRGKRPGRYGGFLLAAYDEESEELAAICKLGTGFSDEELEEHHQNMQALLLPTPRPY 823
Query: 495 V----------WIQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALREDKG 535
V W+ P +V EV ++ SP YR+ G +LRFPR++ +REDK
Sbjct: 824 VRIDGAVAPNHWLDPSIVWEVKCADLTLSPIYRAARGMVDKEKGISLRFPRFIRVREDKQ 883
Query: 536 PEDADTIERIAQLYELQERMKGK 558
PE A T +++A LY Q +++ +
Sbjct: 884 PEQATTSDQVASLYRKQSQIQNQ 906
>gi|4557719 DNA ligase I [Homo sapiens] >gi|118773|sp|P18858|DNL1_HUMAN DNA
LIGASE I (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|88406|pir||A41275 DNA ligase (ATP) (EC 6.5.1.1) I -
human >gi|187143|gb|AAA59518.1| (M36067) DNA ligase I
[Homo sapiens]
Length = 919
Score = 264 bits (667), Expect = 2e-69
Identities = 197/623 (31%), Positives = 315/623 (49%), Gaps = 72/623 (11%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
Y+ +A+ ++K+E+ + +L +++ L+ V P D L + YL L + P EL
Sbjct: 289 YLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVL-YLSLNHLGPPQQGLEL 347
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
GVG+ +L+KAV+ ATG + + + GD+G +A + ++ PLT V+
Sbjct: 348 GVGDGVLLKAVAQATGRQLESVRAEAAEKGDVG-LVAENSRSTQRLMLPPPPLTASGVFS 406
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
+A TG S KK+ + LF+ EA++IAR++ G +R G+AE + A+S A
Sbjct: 407 KFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQA 466
Query: 179 FNV-----------------------KVELVERAYMLTSDFGFVA---KIAKTEGNDGLA 212
++ K L E+ +L F V +I GL
Sbjct: 467 VSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLE 526
Query: 213 KVT----IQIGKPIKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVHK-DGEKVT 265
++ + G P+KPMLA I E L EA F E KYDG R Q+H +G +V
Sbjct: 527 RLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFE-EAAFTCEYKYDGQRAQIHALEGGEVK 585
Query: 266 IYSRRLENVTRAIPEIVEAIKEALKP--TKAIVEGELVAIGEDGRPL-PFQYVLRRFRRK 322
I+SR E+ T P+I+ I + P T I++ E VA + + + PFQ + R R++
Sbjct: 586 IFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKE 645
Query: 323 YNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEE-IVETNGKVKIAENLITKN 381
+ E+ ++ + L FD++Y++G SL+ RR+ L E VET G+ A +L TK+
Sbjct: 646 VDASEI--QVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKD 703
Query: 382 VEEAEQFYKRALEMGHEGLMAKRLD--AVYEPGNRGKKWLKIKPTM-----ENLDLVIIG 434
+E+ +F +++++ EGLM K LD A YE R WLK+K + LDLV+IG
Sbjct: 704 IEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIG 763
Query: 435 AEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKR 494
A G G+RA G F+L +YD ++ E + K+G+GF+D++L E + LK L++
Sbjct: 764 AYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPY 823
Query: 495 V----------WIQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALREDKG 535
V W+ P V EV ++ SP Y + G +LRFPR++ +REDK
Sbjct: 824 VRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQ 883
Query: 536 PEDADTIERIAQLYELQERMKGK 558
PE A T ++A LY Q +++ +
Sbjct: 884 PEQATTSAQVACLYRKQSQIQNQ 906
>gi|11425282 DNA ligase I [Homo sapiens]
Length = 809
Score = 264 bits (667), Expect = 2e-69
Identities = 197/623 (31%), Positives = 315/623 (49%), Gaps = 72/623 (11%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
Y+ +A+ ++K+E+ + +L +++ L+ V P D L + YL L + P EL
Sbjct: 179 YLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVL-YLSLNHLGPPQQGLEL 237
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
GVG+ +L+KAV+ ATG + + + GD+G +A + ++ PLT V+
Sbjct: 238 GVGDGVLLKAVAQATGRQLESVRAEAAEKGDVG-LVAENSRSTQRLMLPPPPLTASGVFS 296
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
+A TG S KK+ + LF+ EA++IAR++ G +R G+AE + A+S A
Sbjct: 297 KFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQA 356
Query: 179 FNV-----------------------KVELVERAYMLTSDFGFVA---KIAKTEGNDGLA 212
++ K L E+ +L F V +I GL
Sbjct: 357 VSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLE 416
Query: 213 KVT----IQIGKPIKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVHK-DGEKVT 265
++ + G P+KPMLA I E L EA F E KYDG R Q+H +G +V
Sbjct: 417 RLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFE-EAAFTCEYKYDGQRAQIHALEGGEVK 475
Query: 266 IYSRRLENVTRAIPEIVEAIKEALKP--TKAIVEGELVAIGEDGRPL-PFQYVLRRFRRK 322
I+SR E+ T P+I+ I + P T I++ E VA + + + PFQ + R R++
Sbjct: 476 IFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKE 535
Query: 323 YNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEE-IVETNGKVKIAENLITKN 381
+ E+ ++ + L FD++Y++G SL+ RR+ L E VET G+ A +L TK+
Sbjct: 536 VDASEI--QVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKD 593
Query: 382 VEEAEQFYKRALEMGHEGLMAKRLD--AVYEPGNRGKKWLKIKPTM-----ENLDLVIIG 434
+E+ +F +++++ EGLM K LD A YE R WLK+K + LDLV+IG
Sbjct: 594 IEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIG 653
Query: 435 AEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKR 494
A G G+RA G F+L +YD ++ E + K+G+GF+D++L E + LK L++
Sbjct: 654 AYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPY 713
Query: 495 V----------WIQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALREDKG 535
V W+ P V EV ++ SP Y + G +LRFPR++ +REDK
Sbjct: 714 VRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQ 773
Query: 536 PEDADTIERIAQLYELQERMKGK 558
PE A T ++A LY Q +++ +
Sbjct: 774 PEQATTSAQVACLYRKQSQIQNQ 796
>sp|P12000|DNLI_SCHPO DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|82819|pir||A29066 DNA ligase (ATP) (EC 6.5.1.1) -
fission yeast (Schizosaccharomyces pombe)
>gi|4925|emb|CAA28754.1| (X05107) DNA ligase
[Schizosaccharomyces pombe]
Length = 768
Score = 261 bits (659), Expect = 2e-68
Identities = 182/608 (29%), Positives = 313/608 (50%), Gaps = 63/608 (10%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDH---LEFIPYLILGDVFPEWDERELG 59
+ E+ + + K+E T+ +L ++ + + DH L YL + + P++ ELG
Sbjct: 149 FAEMVKAFTKIENTSKRLEIIDIMGTYFFGILRDHPSDLLACVYLSINKLGPDYSGLELG 208
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQT 119
+GE +++KA+ +TG ++I+ S GDLG +A ++ + F LTI ++ +
Sbjct: 209 IGESIIMKAIGESTGQTLQQIKLSFHKVGDLG-LVAQTSRQNQPTMFKPAALTIPFLFDS 267
Query: 120 LVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAIS--- 176
L K+A+ +G SQ++K+ + L E E KY+ R + G +R +AE + A++
Sbjct: 268 LKKIAQMSGNQSQNRKIGVIKRLLSSCEGAEPKYLIRALEGKLRLQLAEKTILVALANAT 327
Query: 177 -----------LAFNVKVE---LVERAYMLTSDFGFVAKIAKTEGNDGLAKVT-IQIGKP 221
L+ ++E ++ Y + + G L + + G P
Sbjct: 328 AQYHADKNGEKLSQQDRIEGEQILRDVYCQLPSYDLIVPHLIEHGLGTLRETCKLTPGIP 387
Query: 222 IKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVH--KDGEKVTIYSRRLENVTRA 277
KPMLA+ I E +L +A F E KYDG R QVH +DG K ++SR EN++
Sbjct: 388 TKPMLAKPTKQISE-VLNTFDQAAFTCEYKYDGERAQVHFTEDG-KFYVFSRNSENMSVR 445
Query: 278 IPEIVEAIKEALKPTKAIVEGELVAIG---EDGRPLPFQYVLRRFRRKYNIEEMMEKIPL 334
P+I ++ + KP + A+G ++ + LPFQ + R R+ I ++ K+
Sbjct: 446 YPDISVSVSKWKKPDARSFILDCEAVGWDRDENKILPFQKLATRKRKDVKIGDI--KVRA 503
Query: 335 ELNLFDVLYVDGVSLIDTKFMERRKKLEEIVE-TNGKVKIAENLITKNVEEAEQFYKRAL 393
L FD+LY++G L++T ERRK L + + + G A++ K++E E+F + ++
Sbjct: 504 CLFAFDILYLNGQPLLETPLNERRKLLYSMFQPSTGDFTFAKHSDQKSIESIEEFLEESV 563
Query: 394 EMGHEGLMAKRL---DAVYEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRRAHL 445
+ EGLM K L D+ YEP R + WLK+K ++LDL++IGA +G+G+R +
Sbjct: 564 KDSCEGLMVKMLEGPDSHYEPSKRSRHWLKVKKDYLSGVGDSLDLIVIGAYYGKGKRTSV 623
Query: 446 LGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEE------------GK 493
G+F+LG YDP+T + K+G+GF+++ L F LK ++I ++
Sbjct: 624 YGAFLLGCYDPDTETVQSICKLGTGFSEEHLETFYNQLKDIVISKKKDFYAHSDVPAHQP 683
Query: 494 RVWIQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALREDKGPEDADTIER 544
VW +PK + EV ++ SP Y++ G +LRFPR++ +REDK EDA T E+
Sbjct: 684 DVWFEPKYLWEVLAADLSLSPVYKAAIGYVQEDKGISLRFPRFIRIREDKSWEDATTSEQ 743
Query: 545 IAQLYELQ 552
+++ Y Q
Sbjct: 744 VSEFYRSQ 751
>sp|Q42572|DNLI_ARATH DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|2129574|pir||S71278 DNA ligase (ATP) (EC 6.5.1.1) -
Arabidopsis thaliana >gi|1359495|emb|CAA66599.1|
(X97924) DNA ligase [Arabidopsis thaliana]
Length = 790
Score = 238 bits (600), Expect = 2e-61
Identities = 177/606 (29%), Positives = 301/606 (49%), Gaps = 60/606 (9%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
++ +A + + + +++ T ++ + L+ V PED + + YL ++ P + EL
Sbjct: 177 FLFVALAFDLISNESGRIVITDILCNMLRTVIATTPEDLVATV-YLSANEIAPAHEGVEL 235
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
G+GE +IKA+S A G ++ + GDLG +A + + F +PLT+ +V+
Sbjct: 236 GIGESTIIKAISEAFGRTEDHVKKQNTELGDLG-LVAKGSRSTQTMMFKPEPLTVVKVFD 294
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
T ++A+ +G+ S +KK + L + E Y+ R + +R G + + A+ A
Sbjct: 295 TFRQIAKESGKDSNEKKKNRMKALLVATTDCEPLYLTRLLQAKLRLGFSGQTVLAALGQA 354
Query: 179 F-----------NVK------VELVERAYMLTSDFGFVAKIAKTEGNDGLAKV-TIQIGK 220
N K ++V++ + + + + + G L K +G
Sbjct: 355 AVYNEEHSKPPPNTKSPLEEAAKIVKQVFTVLPVYDIIVPALLSGGVWNLPKTCNFTLGV 414
Query: 221 PIKPMLAQQAANIKEALLEMGGEA-EFEIKYDGARVQVH--KDGEKVTIYSRRLENVTRA 277
PI PMLA+ + E L + E KYDG R Q+H +DG IYSR E T
Sbjct: 415 PIGPMLAKPTKGVAEILNKFQDIVFTCEYKYDGERAQIHFMEDGT-FEIYSRNAERNTGK 473
Query: 278 IPEIVEAIKEALKPT--KAIVEGELVAIGEDGRP-LPFQYVLRRFRRKYNIEEMMEKIPL 334
P++ A+ KP+ I++ E+VA + + LPFQ + R R+ N+ ++ K+ +
Sbjct: 474 YPDVALALSRLKKPSVKSFILDCEVVAFDREKKKILPFQILSTRARKNVNVNDI--KVGV 531
Query: 335 ELNLFDVLYVDGVSLIDTKFMERRKKLEEIVETN-GKVKIAENLITKNVEEAEQFYKRAL 393
+ FD+LY++G LI RR+KL E E + G + A + + +++E ++F ++
Sbjct: 532 CIFAFDMLYLNGQQLIQENLKIRREKLYESFEEDPGYFQFATAVTSNDIDEIQKFLDASV 591
Query: 394 EMGHEGLMAKRLD--AVYEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRRAHLL 446
++G EGL+ K LD A YEP R WLK+K +++DLV I A G G+R +
Sbjct: 592 DVGCEGLIIKTLDSDATYEPAKRSNNWLKLKKDYMDSIGDSVDLVPIPAFHGRGKRTGVY 651
Query: 447 GSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEE----------GKRVW 496
G+F+L YD + EF + K+G+GF+D L E + L+ +I VW
Sbjct: 652 GAFLLACYDVDKEEFQSICKIGTGFSDAMLDERSSSLRSQVIATPKQYYRVGDSLNPDVW 711
Query: 497 IQPKVVIEVTYQEIQKSPKYRS---------GFALRFPRYVALREDKGPEDADTIERIAQ 547
+P V EV ++ SP +R+ G +LRFPR + +REDK PE+A + E+IA
Sbjct: 712 FEPTEVWEVKAADLTISPVHRAATGIVDPDKGISLRFPRLLRVREDKKPEEATSSEQIAD 771
Query: 548 LYELQE 553
LY+ Q+
Sbjct: 772 LYQAQK 777
>pir||T38123 dna ligase - fission yeast (Schizosaccharomyces pombe) (fragment)
>gi|2094856|emb|CAB08595.1| (Z95334) dna ligase
[Schizosaccharomyces pombe]
Length = 362
Score = 189 bits (474), Expect = 9e-47
Identities = 116/341 (34%), Positives = 190/341 (55%), Gaps = 38/341 (11%)
Query: 247 EIKYDGARVQVH--KDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGELVAIG 304
E KYDG R QVH +DG K ++SR EN++ P+I ++ + KP + A+G
Sbjct: 8 EYKYDGERAQVHFTEDG-KFYVFSRNSENMSVRYPDISVSVSKWKKPDARSFILDCEAVG 66
Query: 305 ---EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL 361
++ + LPFQ + R R+ I ++ K+ L FD+LY++G L++T ERRK L
Sbjct: 67 WDRDENKILPFQKLATRKRKDVKIGDI--KVRACLFAFDILYLNGQPLLETPLNERRKLL 124
Query: 362 EEIVE-TNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRL---DAVYEPGNRGKK 417
+ + + G A++ K++E E+F + +++ EGLM K L D+ YEP R +
Sbjct: 125 YSMFQPSTGDFTFAKHSDQKSIESIEEFLEESVKDSCEGLMVKMLEGPDSHYEPSKRSRH 184
Query: 418 WLKIKPTM-----ENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFT 472
WLK+K ++LDL++IGA +G+G+R + G+F+LG YDP+T + K+G+GF+
Sbjct: 185 WLKVKKDYLSGVGDSLDLIVIGAYYGKGKRTSVYGAFLLGCYDPDTETVQSICKLGTGFS 244
Query: 473 DDDLVEFTKMLKPLIIKEE------------GKRVWIQPKVVIEVTYQEIQKSPKYRS-- 518
++ L F LK ++I ++ VW +PK + EV ++ SP Y++
Sbjct: 245 EEHLETFYNQLKDIVISKKKDFYAHSDVPAHQPDVWFEPKYLWEVLAADLSLSPVYKAAI 304
Query: 519 -------GFALRFPRYVALREDKGPEDADTIERIAQLYELQ 552
G +LRFPR++ +REDK EDA T E++++ Y Q
Sbjct: 305 GYVQEDKGISLRFPRFIRIREDKSWEDATTSEQVSEFYRSQ 345
>gb|AAF79833.1|AC026875_13 (AC026875) T6D22.23 [Arabidopsis thaliana]
Length = 839
Score = 187 bits (470), Expect = 3e-46
Identities = 164/631 (25%), Positives = 286/631 (44%), Gaps = 112/631 (17%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
++ +A + + + +++ T ++ + L+ V PED + + YL ++ P + EL
Sbjct: 177 FLFVALAFDLISNESGRIVITDILCNMLRTVIATTPEDLVATV-YLSANEIAPAHEGVEL 235
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
G+GE +IKA+S A G ++ + GDLG +A + + F +PLT+ +V+
Sbjct: 236 GIGESTIIKAISEAFGRTEDHVKKQNTELGDLG-LVAKGSRSTQTMMFKPEPLTVVKVFD 294
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
T ++A+ +G+ S +KK + L + E Y+ R + +R G + + A+ A
Sbjct: 295 TFRQIAKESGKDSNEKKKNRMKALLVATTDCEPLYLTRLLQAKLRLGFSGQTVLAALGQA 354
Query: 179 F-----------NVK------VELVERAYMLTSDFGFVAKIAKTEGNDGLAKV-TIQIGK 220
N K ++V++ + + + + + G L K +G
Sbjct: 355 AVYNEEHSKPPPNTKSPLEEAAKIVKQVFTVLPVYDIIVPALLSGGVWNLPKTCNFTLGV 414
Query: 221 PIKPMLAQQAANIKEALLEMGGEA-EFEIKYDGARVQVH--KDGEKVTIYSRRLENVTRA 277
PI PMLA+ + E L + E KYDG R Q+H +DG IYSR E T
Sbjct: 415 PIGPMLAKPTKGVAEILNKFQDIVFTCEYKYDGERAQIHFMEDGT-FEIYSRNAERNTGK 473
Query: 278 IPEIVEAIKEALKPT--KAIVEGELVAIGEDGRP-LPFQYVLRRFRRKYNIEEMMEKIPL 334
P++ A+ KP+ I++ E+VA + + LPFQ + R R+ N+ ++ K+ +
Sbjct: 474 YPDVALALSRLKKPSVKSFILDCEVVAFDREKKKILPFQILSTRARKNVNVNDI--KVGV 531
Query: 335 ELNLFDVLYVDGVSLIDTKFMERRKKLEEIVETN-GKVKIAENLITKNVEEAEQFYKRAL 393
+ FD+LY++G LI RR+KL E E + G + A + + +++E ++F ++
Sbjct: 532 CIFAFDMLYLNGQQLIQENLKIRREKLYESFEEDPGYFQFATAVTSNDIDEIQKFLDASV 591
Query: 394 EMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGA 453
++G +++DLV I A G G+R + G+F+L
Sbjct: 592 DVG---------------------------IGDSVDLVPIAAFHGRGKRTGVYGAFLLAC 624
Query: 454 YDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII---KEE------------------- 491
YD + EF + K+G+GF+D L E + L+ +I K E
Sbjct: 625 YDVDKEEFQSICKIGTGFSDAMLDERSSSLRSQVIATPKHEFLFNCNDSNIQQYYRVGDS 684
Query: 492 -GKRVWIQPK-------------------VVIEVTYQEIQKSPKYRS---------GFAL 522
VW +P V EV ++ SP +R+ G +L
Sbjct: 685 LNPDVWFEPTEFRHSIVWVEMKGKKYVCLKVWEVKAADLTISPVHRAATGIVDPDKGISL 744
Query: 523 RFPRYVALREDKGPEDADTIERIAQLYELQE 553
RFPR + +REDK PE+A + E+IA LY+ Q+
Sbjct: 745 RFPRLLRVREDKKPEEATSSEQIADLYQAQK 775
>gb|AAF18258.1|AC011438_20 (AC011438) T23G18.1 [Arabidopsis thaliana]
Length = 794
Score = 185 bits (464), Expect = 1e-45
Identities = 164/637 (25%), Positives = 286/637 (44%), Gaps = 118/637 (18%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKV----PEDHLEFIPYLILGDVFPEWDEREL 58
++ +A + + + +++ T ++ + L+ V PED + + YL ++ P + EL
Sbjct: 177 FLFVALAFDLISNESGRIVITDILCNMLRTVIATTPEDLVATV-YLSANEIAPAHEGVEL 235
Query: 59 GVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQ 118
G+GE +IKA+S A G ++ + GDLG +A + + F +PLT+ +V+
Sbjct: 236 GIGESTIIKAISEAFGRTEDHVKKQNTELGDLG-LVAKGSRSTQTMMFKPEPLTVVKVFD 294
Query: 119 TLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLA 178
T ++A+ +G+ S +KK + L + E Y+ R + +R G + + A+ A
Sbjct: 295 TFRQIAKESGKDSNEKKKNRMKALLVATTDCEPLYLTRLLQAKLRLGFSGQTVLAALGQA 354
Query: 179 F-----------NVK------VELVERAYMLTSDFGFVAKIAKTEGNDGLAKV-TIQIGK 220
N K ++V++ + + + + + G L K +G
Sbjct: 355 AVYNEEHSKPPPNTKSPLEEAAKIVKQVFTVLPVYDIIVPALLSGGVWNLPKTCNFTLGV 414
Query: 221 PIKPMLAQQAANIKEALLEMGGEA-EFEIKYDGARVQVH--KDGEKVTIYSRRLENVTRA 277
PI PMLA+ + E L + E KYDG R Q+H +DG IYSR E T
Sbjct: 415 PIGPMLAKPTKGVAEILNKFQDIVFTCEYKYDGERAQIHFMEDGT-FEIYSRNAERNTGK 473
Query: 278 IPEIVEAIKEALKPT--KAIVEGELVAIGEDGRP-LPFQYVLRRFRRKYNIEEMMEKIPL 334
P++ A+ KP+ I++ E+VA + + LPFQ + R R+ N+ ++ K+ +
Sbjct: 474 YPDVALALSRLKKPSVKSFILDCEVVAFDREKKKILPFQILSTRARKNVNVNDI--KVGV 531
Query: 335 ELNLFDVLYVDGVSLIDTKFMERRKKLEEIVETN-GKVKIAENLITKNVEEAEQFYKRAL 393
+ FD+LY++G LI RR+KL E E + G + A + + +++E ++F ++
Sbjct: 532 CIFAFDMLYLNGQQLIQENLKIRREKLYESFEEDPGYFQFATAVTSNDIDEIQKFLDASV 591
Query: 394 EMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGA 453
++G +++DLV I A G G+R + G+F+L
Sbjct: 592 DVG---------------------------IGDSVDLVPIAAFHGRGKRTGVYGAFLLAC 624
Query: 454 YDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII---KEE------------------- 491
YD + EF + K+G+GF+D L E + L+ +I K E
Sbjct: 625 YDVDKEEFQSICKIGTGFSDAMLDERSSSLRSQVIATPKHEFLFNCNDSNIQQYYRVGDS 684
Query: 492 -GKRVWIQPK-------------------------VVIEVTYQEIQKSPKYRS------- 518
VW +P V EV ++ SP +R+
Sbjct: 685 LNPDVWFEPTEVGLCLLFRHSIVWVEMKGKKYVCLKVWEVKAADLTISPVHRAATGIVDP 744
Query: 519 --GFALRFPRYVALREDKGPEDADTIERIAQLYELQE 553
G +LRFPR + +REDK PE+A + E+IA LY+ Q+
Sbjct: 745 DKGISLRFPRLLRVREDKKPEEATSSEQIADLYQAQK 781
>pir||T37436 DNA ligase - vaccinia virus (strain Ankara)
>gi|2772802|gb|AAB96541.1| (U94848) DNA ligase [Vaccinia
virus]
Length = 552
Score = 173 bits (435), Expect = 4e-42
Identities = 147/558 (26%), Positives = 263/558 (46%), Gaps = 62/558 (11%)
Query: 22 KTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEIE 81
K++L+ DF+ + YLI+ + P D+R + +K +IK S+ I + E
Sbjct: 23 KSKLIRDFITDRDDK------YLIIKLLLPGLDDRIYNMNDKQIIKLYSI---IFKQSQE 73
Query: 82 NSVKDTGD--LGESIALAVKKRKQ-KSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKY 138
+ ++D G +G++I K+ + + LT++ V L ++ T E Q K +
Sbjct: 74 DMLQDLGYGYIGDTIRTFFKENTEIRPRDKSILTLEEVDSFLTTLSSVTKESHQIKLLTD 133
Query: 139 LANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGF 198
+A++ + K + + ++ + +AIS AY +
Sbjct: 134 IASV---CTCNDLKCVVMLIDKDLKIKAGPRYVLNAIS----------PHAYDVFRKSNN 180
Query: 199 VAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVH 258
+ +I + L ++I + PI PMLA+ ++ +A + E+KYDG RVQVH
Sbjct: 181 LKEIIENASKQNLDSISISVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVH 240
Query: 259 KDGEKVTIYSRRLENV-TRAIPEIVEAIKEAL-KPTKAIVEGELVAIGEDGRPLPFQYVL 316
K+ + +SR ++ V + + + E I +A K T +++ E+V + E PLPF +
Sbjct: 241 KNNNEFAFFSRNMKPVLSHKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVPLPFGSLG 300
Query: 317 RRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAE 375
+++Y M L +FD LY DG + D ERR L+++ VE ++ +E
Sbjct: 301 IHKKKEYKNSNMC------LFVFDCLYFDGFDMTDIPLYERRSFLKDVMVEIPNRIVFSE 354
Query: 376 NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENL 428
N + AL EGL+ K ++ VYEPG R +WLKIK ++
Sbjct: 355 LTNISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKR--RWLKIKRDYLNEGSMADSA 412
Query: 429 DLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII 488
DLV++GA +G+G + ++ F++G YD E+G++ V K SG D+ L E LK + I
Sbjct: 413 DLVVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKC-SGHDDNTLRELQDQLKMIKI 471
Query: 489 KEEGKRV--WI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVAL 530
++ K++ W+ PK + E++ E S + +G ++RFPR+ +
Sbjct: 472 NKDPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRI 531
Query: 531 REDKGPEDADTIERIAQL 548
REDK +++ + + L
Sbjct: 532 REDKTWKESTHLNDLVNL 549
>gi|9634571 TA61R [Vaccinia virus (strain Tian Tan)] >gi|6969850|gb|AAF34062.1|
(AF095689) TA61R [Vaccinia virus (strain Tian Tan)]
Length = 552
Score = 169 bits (425), Expect = 5e-41
Identities = 146/558 (26%), Positives = 261/558 (46%), Gaps = 62/558 (11%)
Query: 22 KTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEIE 81
K++L+ DF+ + YLI+ + P D+R + +K +IK S+ I + E
Sbjct: 23 KSKLIRDFITDRDDK------YLIIKLLLPGLDDRIYNMNDKQIIKLYSI---IFKQSQE 73
Query: 82 NSVKDTGD--LGESIALAVKKRKQ-KSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKY 138
+ ++D G +G++I K+ + + LT++ V L ++ T E Q +K
Sbjct: 74 DMLQDLGYGYIGDTIRTFFKENTEIRPRDKSILTLEDVDSFLTTLSSVTKESHQ---IKL 130
Query: 139 LANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGF 198
L ++ + K + + ++ + +AIS AY +
Sbjct: 131 LTDIAFVCTCNDLKCVVMLIDKDLKIKAGPRYVLNAIS----------PNAYDVFRKSNN 180
Query: 199 VAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVH 258
+ +I + L ++I + PI PMLA+ ++ +A + E+KYDG RVQVH
Sbjct: 181 LKEIIENSSKQNLDFISISVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVH 240
Query: 259 KDGEKVTIYSRRLENV-TRAIPEIVEAIKEAL-KPTKAIVEGELVAIGEDGRPLPFQYVL 316
K+ + +SR ++ V + + + E I +A K T +++ E+V + E PLPF +
Sbjct: 241 KNNNEFAFFSRNMKPVLSHKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVPLPFGSLG 300
Query: 317 RRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAE 375
+++Y M L +FD LY DG + D ERR L+++ VE ++ +E
Sbjct: 301 IHKKKEYKNSNMC------LFVFDCLYFDGFDMTDIPLYERRSFLKDVMVEIPNRIVFSE 354
Query: 376 NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENL 428
N + AL EGL+ K ++ VYEPG R +WLKIK ++
Sbjct: 355 LTNISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKR--RWLKIKRDYLNEGSMADSA 412
Query: 429 DLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII 488
DLV++GA +G+G + ++ F++G YD E+G++ V K SG D+ L LK + I
Sbjct: 413 DLVVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKC-SGHDDNTLRVLQDQLKMIKI 471
Query: 489 KEEGKRV--WI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVAL 530
++ K++ W+ PK + E++ E S + +G ++RFPR+ +
Sbjct: 472 NKDPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRI 531
Query: 531 REDKGPEDADTIERIAQL 548
REDK +++ + + L
Sbjct: 532 REDKTWKESTHLNDLVNL 549
>gi|9791118 A50R; putative [Vaccinia virus] >gi|118775|sp|P20492|DNLI_VACCC DNA
LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|68668|pir||WMVZ7W DNA ligase (ATP) (EC 6.5.1.1) -
vaccinia virus (strain Copenhagen)
>gi|335530|gb|AAA48182.1| (M35027) A50R; putative
[Vaccinia virus]
Length = 552
Score = 168 bits (421), Expect = 2e-40
Identities = 145/558 (25%), Positives = 261/558 (45%), Gaps = 62/558 (11%)
Query: 22 KTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEIE 81
K++L+ DF+ + YLI+ + P D+R + +K +IK S+ I + E
Sbjct: 23 KSKLIRDFITDRDDK------YLIIKLLLPGLDDRIYNMNDKQIIKLYSI---IFKQSQE 73
Query: 82 NSVKDTGD--LGESIALAVKKRKQ-KSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKY 138
+ ++D G +G++I K+ + + LT++ V L ++ T E Q K +
Sbjct: 74 DMLQDLGYGYIGDTIRTFFKENTEIRPRDKSILTLEDVDSFLTTLSSVTKESHQIKLLTD 133
Query: 139 LANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGF 198
+A++ + K + + ++ + +AIS AY +
Sbjct: 134 IASV---CTCNDLKCVVMLIDKDLKIKAGPRYVLNAIS----------PNAYDVFRKSNN 180
Query: 199 VAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVH 258
+ +I + L ++I + PI PMLA+ ++ +A + E+KYDG RVQVH
Sbjct: 181 LKEIIENSSKQNLDSISISVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVH 240
Query: 259 KDGEKVTIYSRRLENV-TRAIPEIVEAIKEAL-KPTKAIVEGELVAIGEDGRPLPFQYVL 316
K+ + +SR ++ V + + + E I +A K T +++ E+V + E PLPF +
Sbjct: 241 KNNNEFAFFSRNMKPVLSHKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVPLPFGSLG 300
Query: 317 RRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAE 375
+++Y M L +FD LY DG + D ERR L+++ VE ++ +E
Sbjct: 301 IHKKKEYKNSNMC------LFVFDCLYFDGFDMTDIPLYERRSFLKDVMVEIPNRIVFSE 354
Query: 376 NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENL 428
N + AL EGL+ K ++ VYEPG R +WLKIK ++
Sbjct: 355 LTNISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKR--RWLKIKRDYLNEGSMADSA 412
Query: 429 DLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII 488
DLV++GA +G+G + ++ F++G YD E+G++ V K SG D+ L L + I
Sbjct: 413 DLVVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKC-SGHDDNTLRVLQDQLTMIKI 471
Query: 489 KEEGKRV--WI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVAL 530
++ K++ W+ PK + E++ E S + +G ++RFPR+ +
Sbjct: 472 NKDPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRI 531
Query: 531 REDKGPEDADTIERIAQL 548
REDK +++ + + L
Sbjct: 532 REDKTWKESTHLNDLVNL 549
>gi|11499314 DNA ligase, putative [Archaeoglobus fulgidus]
>gi|7483285|pir||D69465 DNA ligase homolog -
Archaeoglobus fulgidus >gi|2648829|gb|AAB89526.1|
(AE000984) DNA ligase, putative [Archaeoglobus fulgidus]
Length = 313
Score = 168 bits (421), Expect = 2e-40
Identities = 118/330 (35%), Positives = 182/330 (54%), Gaps = 37/330 (11%)
Query: 220 KPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKD--GEKVTIYSRRLENVTRA 277
K IKPMLA ++ + +E+K+DG R D G++V + +RRL ++T
Sbjct: 6 KKIKPMLAVRSKPFSS------DDHIYEVKWDGTRCLAFVDVEGKRVRLQNRRLLDITYR 59
Query: 278 IPEI--VEAIKEALKPTKAIVEGELVAIGEDGRP-LPFQYVLRRFRRKYNIEEMMEKIPL 334
PEI ++A++ AI++GE+V I +DG+P P ++ IE + + IP
Sbjct: 60 YPEIKLLDAVER-----NAILDGEVVVI-KDGKPSFPLLQKREHVDSRFKIEILSKTIPA 113
Query: 335 ELNLFDVLYVDGVSLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALE 394
+FDVLY DG ++D + MER+K L E++++ G+V + E + K E+FY++A+E
Sbjct: 114 VYIVFDVLYCDGW-VVDLELMERKKILSEVLQSRGRVVVEEWIEGKG----EEFYRKAVE 168
Query: 395 MGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAY 454
MG EG++AK+ D Y G R + W KIK LD VI+G GEG RA GS +L Y
Sbjct: 169 MGLEGIVAKKKDGRYLIGKRSRLWKKIK-KRNTLDCVIVGWIEGEGERAKTFGSLVLAVY 227
Query: 455 DPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKE-----EGKRV-WIQPKVVIEVTYQ 508
E G VG VG+GF + L F++ L+ + + + E K V W++P+ V EV +
Sbjct: 228 --EDGRLKHVGNVGTGFDSEFLNWFSERLREIEVAKPHFEIETKNVHWVKPRYVCEVEFL 285
Query: 509 EIQKSPKYRSGFALRFPRYVALREDKGPED 538
E + K LR P ++ LREDK P++
Sbjct: 286 EFTEDGK------LRAPVFLRLREDKSPDE 309
>sp|P16272|DNLI_VACCV DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|321416|pir||JQ1788 DNA ligase (ATP) (EC 6.5.1.1) -
vaccinia virus (strain WR) >gi|62230|emb|CAA34519.1|
(X16512) DNA ligase homologue (AA 1-552) [Vaccinia
virus] >gi|222739|dbj|BAA01824.1| (D11079) 63.3K protein
[Vaccinia virus]
Length = 552
Score = 167 bits (419), Expect = 3e-40
Identities = 145/558 (25%), Positives = 261/558 (45%), Gaps = 62/558 (11%)
Query: 22 KTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEIE 81
K++L+ DF+ + YLI+ + P D+R + +K +IK S+ I + E
Sbjct: 23 KSKLIRDFITDRDDK------YLIIKLLLPGLDDRIYNMNDKQIIKLYSI---IFKQSQE 73
Query: 82 NSVKDTGD--LGESIALAVKKRKQ-KSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKY 138
+ ++D G +G++I K+ + + LT++ V L ++ T E Q K +
Sbjct: 74 DMLQDLGYGYIGDTIRTFFKENTEIRPRDKSILTLEDVDSFLTTLSSVTKESHQIKLLTD 133
Query: 139 LANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGF 198
+A++ + K + + ++ + +AIS AY +
Sbjct: 134 IASV---CTCNDLKCVVMLIDKDLKIKAGPRYVLNAIS----------PNAYDVFRKSNN 180
Query: 199 VAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVH 258
+ +I + L ++I + PI PMLA+ ++ +A + E+KYDG RVQVH
Sbjct: 181 LKEIIENASKQNLDSISISVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVH 240
Query: 259 KDGEKVTIYSRRLENV-TRAIPEIVEAIKEAL-KPTKAIVEGELVAIGEDGRPLPFQYVL 316
K+ + +SR ++ V + + + E I +A K T +++ E+V + E PLPF +
Sbjct: 241 KNNNEFAFFSRNMKPVLSHKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVPLPFGSLG 300
Query: 317 RRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAE 375
+++Y M L +FD LY DG + D ERR L+++ VE ++ +E
Sbjct: 301 IHKKKEYKNSNMC------LFVFDCLYFDGFDMTDIPLYERRSFLKDVMVEIPNRIVFSE 354
Query: 376 NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENL 428
N + AL EGL+ K ++ VYEPG R +WLKIK ++
Sbjct: 355 LTNISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKR--RWLKIKRDYLNEGSMADSA 412
Query: 429 DLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII 488
DLV++GA +G+G + ++ F++G YD E+G++ V K SG D+ L L + I
Sbjct: 413 DLVVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKC-SGHDDNTLRVLQDQLTMVKI 471
Query: 489 KEEGKRV--WI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVAL 530
++ K++ W+ PK + E++ E S + +G ++RFPR+ +
Sbjct: 472 NKDPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRI 531
Query: 531 REDKGPEDADTIERIAQL 548
REDK +++ + + L
Sbjct: 532 REDKTWKESTHLNDLVNL 549
>gi|9634713 ORF FPV043 DNA ligase [Fowlpox virus]
>gi|7271541|gb|AAF44387.1|AF198100_34 (AF198100) ORF
FPV043 DNA ligase [Fowlpox virus]
Length = 564
Score = 166 bits (417), Expect = 5e-40
Identities = 150/574 (26%), Positives = 257/574 (44%), Gaps = 54/574 (9%)
Query: 5 ELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKL 64
E +L + + + KT+L+++F+ + D+ + Y+I + P + + +K
Sbjct: 7 EFRELCTSISTESSYVKKTKLISEFIHR-GRDYNDV--YIITKLLLPGTGKLIYNINDKQ 63
Query: 65 LIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFS--QPLTIKRVYQTLVK 122
L+K S D+ E+ V + GD+ I +KK K ++ LT+ V L +
Sbjct: 64 LVKLFSKIFCHDADEMYKYVINIGDVAYVIGSFLKKSKSVVDYATESTLTLHEVDCFLTR 123
Query: 123 VAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVK 182
++ T E Q K++K + P + ++I R + +R + +V
Sbjct: 124 LSTVTRENDQIKEIK---KIIPRCTPNDLRHIIRLIKHDLRMNIGPK----------HVL 170
Query: 183 VELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGG 242
L + AY + + ++ + D + K I++ P++PMLA EA+ +
Sbjct: 171 SGLHKDAYGIFKLCNNLEQVVQRSLEDNI-KPLIELMVPLQPMLASACKTFSEAVKKCPN 229
Query: 243 EAEFEIKYDGARVQVHKDGEKVTIYSRRLENVT-RAIPEIVEAIKEALKPTK-AIVEGEL 300
E KYDG R+Q+HK + +SR L+ +T + + E + A K I++GE+
Sbjct: 230 GIIVEFKYDGERIQIHKHDKNFKYFSRSLKPITPHKVTDFEELLDRAFPSAKNMILDGEI 289
Query: 301 VAIG-EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRK 359
+ I E +PLPF + N + M + + +FD LY + LID +ERR
Sbjct: 290 ILIDTETNQPLPFGTL------GINKKSMYHNACVCIFIFDCLYFNDTVLIDKPLIERRN 343
Query: 360 KLE-EIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKW 418
+ I E ++ ++E EE + L EG + K VYEPG R +W
Sbjct: 344 IIHANIKEIPNRILLSEVKNISTDEELSKLLHIVLSKNIEGFVLKDAKGVYEPGMR--RW 401
Query: 419 LKIKPTM-------ENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGF 471
LKIK + DLV++GA +G+G ++ +L SF++G YD ++ ++ V K G
Sbjct: 402 LKIKKDYLDGCVMADKADLVVLGAYYGKGNKSGILSSFLMGCYDTKSEKWCTVTKCSGGH 461
Query: 472 TDDDLVEFTKMLKPLIIKEEGKRVWIQ------PKVVI---------EVTYQEIQKSPKY 516
TD +L E L + W+ P V+I E+ E +S +
Sbjct: 462 TDLELQEINDNLSVVPFDRNAIPDWLSINKIHYPDVIISDISLAPVWEIIGSEFTRSSTH 521
Query: 517 -RSGFALRFPRYVALREDKGPEDADTIERIAQLY 549
S ++RFPR +REDK E A+ + I QLY
Sbjct: 522 TASNISIRFPRCSRIREDKTYETANNLNDIKQLY 555
>sp|Q67480|DNLI_FOWPM DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|540667|pir||S41974 DNA ligase (ATP) (EC 6.5.1.1) -
fowlpox virus >gi|453602|emb|CAA82805.1| (Z29716) DNA
ligase [Fowlpox virus]
Length = 564
Score = 165 bits (413), Expect = 1e-39
Identities = 149/574 (25%), Positives = 256/574 (43%), Gaps = 54/574 (9%)
Query: 5 ELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKL 64
E +L + + + KT+L+++F+ + D+ + Y+I + P + + +K
Sbjct: 7 EFRELCTSISTESSYVKKTKLISEFIHR-GRDYNDV--YIITKLLLPGTGKLIYNINDKQ 63
Query: 65 LIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFS--QPLTIKRVYQTLVK 122
L+K S D+ E+ V + GD+ I +KK K ++ LT+ V L +
Sbjct: 64 LVKLFSKIFCHDADEMYKYVINIGDVAYVIGSFLKKSKSVVDYATESTLTLHEVDCFLTR 123
Query: 123 VAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVK 182
++ T E Q K++K + P + ++I R + +R + +V
Sbjct: 124 LSTVTRENDQIKEIK---KIIPRCTPNDLRHIIRLIKHDLRMNIGPK----------HVL 170
Query: 183 VELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGG 242
L + AY + + ++ + D + K I++ P++PMLA EA+ +
Sbjct: 171 SGLHKDAYGIFKLCNNLEQVVQRSLEDNI-KPLIELMVPLQPMLASACKTFSEAVKKCPN 229
Query: 243 EAEFEIKYDGARVQVHKDGEKVTIYSRRLENVT-RAIPEIVEAIKEAL-KPTKAIVEGEL 300
E KYDG R+Q+HK + +SR L+ +T + + E + A I++GE+
Sbjct: 230 GIIVEFKYDGERIQIHKHDKNFKYFSRSLKPITPHKVTDFEELLDRAFPSANNMILDGEI 289
Query: 301 VAIG-EDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRK 359
+ I E +PLPF + N + M + + +FD LY + LID +ERR
Sbjct: 290 ILIDTETNQPLPFGTL------GINKKSMYHNACVCIFIFDCLYFNDTVLIDKPLIERRN 343
Query: 360 KLE-EIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKW 418
+ I E ++ ++E EE + L EG + K VYEPG R +W
Sbjct: 344 IIHANIKEIPNRILLSEVKNISTDEELSKLLHIVLSKNIEGFVLKDAKGVYEPGMR--RW 401
Query: 419 LKIKPTM-------ENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGF 471
LKIK + DLV++GA +G+G ++ +L SF++G YD ++ ++ V K G
Sbjct: 402 LKIKKDYLDGCVMADKADLVVLGAYYGKGNKSGILSSFLMGCYDTKSEKWCTVTKCSGGH 461
Query: 472 TDDDLVEFTKMLKPLIIKEEGKRVWIQ------PKVVI---------EVTYQEIQKSPKY 516
TD +L E L + W+ P V+I E+ E +S +
Sbjct: 462 TDLELQEINDNLSVVPFDRNAIPDWLSINKIHYPDVIISDISLAPVWEIIGSEFTRSSTH 521
Query: 517 -RSGFALRFPRYVALREDKGPEDADTIERIAQLY 549
S ++RFPR +REDK E A+ + I QLY
Sbjct: 522 TASNISIRFPRCSRIREDKTYETANNLNDIKQLY 555
>gi|7710126 ligase III, DNA, ATP-dependent, isoform beta [Homo sapiens]
>gi|1706481|sp|P49916|DNL3_HUMAN DNA LIGASE III
(POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|7512394|pir||I37292 DNA ligase (ATP) (EC 6.5.1.1)
III - human >gi|860963|emb|CAA59230.1| (X84740) DNA
ligase III [Homo sapiens]
Length = 922
Score = 164 bits (412), Expect = 2e-39
Identities = 147/571 (25%), Positives = 272/571 (46%), Gaps = 58/571 (10%)
Query: 22 KTRLVADFLKKVPE-DHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEI 80
KT+++ DFL+K D YL + + P + + +K ++K S + ++
Sbjct: 195 KTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDM 254
Query: 81 ENSVKDTGDLGESIALAVKKRKQKSFFSQPL-TIKRVYQTLVKVAETTGEGSQDKKMKYL 139
++ GD+ E+I + ++ K ++ L TI+ V + L+++++ T E Q + ++ +
Sbjct: 255 ARDLEQ-GDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDI 313
Query: 140 ANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISL----AFNVKVELVERAYMLTSD 195
A+ + K I R + ++ + DA+ AF L + + +
Sbjct: 314 ASR---CTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHN 370
Query: 196 FGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARV 255
++ K G V + P++PMLA+ +++ A+ + EIKYDG RV
Sbjct: 371 ---AQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERV 427
Query: 256 QVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPT-----KAIVEGELVAI-GEDGRP 309
QVHK+G+ + +SR L+ V +P V K+ + I++ E++ I + G+P
Sbjct: 428 QVHKNGDHFSYFSRSLKPV---LPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKP 484
Query: 310 LPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL-EEIVETN 368
LPF + + + + + L +FD +Y + VSL+D ERRK L + +VE
Sbjct: 485 LPFGTL------GVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIP 538
Query: 369 GKVKIAE-NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMEN 427
++ +E +TK ++ A+ R ++ G EGL+ K + YEPG R WLK+K N
Sbjct: 539 NRIMFSEMKRVTKALDLADMI-TRVIQEGLEGLVLKDVKGTYEPGKR--HWLKVKKDYLN 595
Query: 428 -------LDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
DLV++GA +G+G + ++ F++G YDP + ++ V K G D L
Sbjct: 596 EGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQ 655
Query: 481 KMLKPLIIKEEGKRV--WIQ-------------PK--VVIEVTYQEIQKSPKYRS-GFAL 522
L + I ++ ++ W++ PK V E+T E KS + + G ++
Sbjct: 656 NELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISI 715
Query: 523 RFPRYVALREDKGPEDADTIERIAQLYELQE 553
RFPR +R+DK + A + ++ +LY+L +
Sbjct: 716 RFPRCTRIRDDKDWKSATNLPQLKELYQLSK 746
>gi|4504995 ligase III, DNA, ATP-dependent, isoform beta [Homo sapiens]
>gi|1113939|gb|AAA85022.1| (U40671) DNA ligase III [Homo
sapiens]
Length = 862
Score = 164 bits (412), Expect = 2e-39
Identities = 147/571 (25%), Positives = 272/571 (46%), Gaps = 58/571 (10%)
Query: 22 KTRLVADFLKKVPE-DHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEI 80
KT+++ DFL+K D YL + + P + + +K ++K S + ++
Sbjct: 195 KTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDM 254
Query: 81 ENSVKDTGDLGESIALAVKKRKQKSFFSQPL-TIKRVYQTLVKVAETTGEGSQDKKMKYL 139
++ GD+ E+I + ++ K ++ L TI+ V + L+++++ T E Q + ++ +
Sbjct: 255 ARDLEQ-GDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDI 313
Query: 140 ANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISL----AFNVKVELVERAYMLTSD 195
A+ + K I R + ++ + DA+ AF L + + +
Sbjct: 314 ASR---CTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHN 370
Query: 196 FGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARV 255
++ K G V + P++PMLA+ +++ A+ + EIKYDG RV
Sbjct: 371 ---AQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERV 427
Query: 256 QVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPT-----KAIVEGELVAI-GEDGRP 309
QVHK+G+ + +SR L+ V +P V K+ + I++ E++ I + G+P
Sbjct: 428 QVHKNGDHFSYFSRSLKPV---LPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKP 484
Query: 310 LPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL-EEIVETN 368
LPF + + + + + L +FD +Y + VSL+D ERRK L + +VE
Sbjct: 485 LPFGTL------GVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIP 538
Query: 369 GKVKIAE-NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMEN 427
++ +E +TK ++ A+ R ++ G EGL+ K + YEPG R WLK+K N
Sbjct: 539 NRIMFSEMKRVTKALDLADMI-TRVIQEGLEGLVLKDVKGTYEPGKR--HWLKVKKDYLN 595
Query: 428 -------LDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
DLV++GA +G+G + ++ F++G YDP + ++ V K G D L
Sbjct: 596 EGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQ 655
Query: 481 KMLKPLIIKEEGKRV--WIQ-------------PK--VVIEVTYQEIQKSPKYRS-GFAL 522
L + I ++ ++ W++ PK V E+T E KS + + G ++
Sbjct: 656 NELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISI 715
Query: 523 RFPRYVALREDKGPEDADTIERIAQLYELQE 553
RFPR +R+DK + A + ++ +LY+L +
Sbjct: 716 RFPRCTRIRDDKDWKSATNLPQLKELYQLSK 746
>gi|11425554 ligase III, DNA, ATP-dependent, isoform beta [Homo sapiens]
Length = 949
Score = 164 bits (412), Expect = 2e-39
Identities = 147/571 (25%), Positives = 272/571 (46%), Gaps = 58/571 (10%)
Query: 22 KTRLVADFLKKVPE-DHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEI 80
KT+++ DFL+K D YL + + P + + +K ++K S + ++
Sbjct: 282 KTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDM 341
Query: 81 ENSVKDTGDLGESIALAVKKRKQKSFFSQPL-TIKRVYQTLVKVAETTGEGSQDKKMKYL 139
++ GD+ E+I + ++ K ++ L TI+ V + L+++++ T E Q + ++ +
Sbjct: 342 ARDLEQ-GDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDI 400
Query: 140 ANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISL----AFNVKVELVERAYMLTSD 195
A+ + K I R + ++ + DA+ AF L + + +
Sbjct: 401 ASR---CTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHN 457
Query: 196 FGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARV 255
++ K G V + P++PMLA+ +++ A+ + EIKYDG RV
Sbjct: 458 ---AQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERV 514
Query: 256 QVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPT-----KAIVEGELVAI-GEDGRP 309
QVHK+G+ + +SR L+ V +P V K+ + I++ E++ I + G+P
Sbjct: 515 QVHKNGDHFSYFSRSLKPV---LPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKP 571
Query: 310 LPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL-EEIVETN 368
LPF + + + + + L +FD +Y + VSL+D ERRK L + +VE
Sbjct: 572 LPFGTL------GVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIP 625
Query: 369 GKVKIAE-NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMEN 427
++ +E +TK ++ A+ R ++ G EGL+ K + YEPG R WLK+K N
Sbjct: 626 NRIMFSEMKRVTKALDLADMI-TRVIQEGLEGLVLKDVKGTYEPGKR--HWLKVKKDYLN 682
Query: 428 -------LDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
DLV++GA +G+G + ++ F++G YDP + ++ V K G D L
Sbjct: 683 EGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQ 742
Query: 481 KMLKPLIIKEEGKRV--WIQ-------------PK--VVIEVTYQEIQKSPKYRS-GFAL 522
L + I ++ ++ W++ PK V E+T E KS + + G ++
Sbjct: 743 NELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISI 802
Query: 523 RFPRYVALREDKGPEDADTIERIAQLYELQE 553
RFPR +R+DK + A + ++ +LY+L +
Sbjct: 803 RFPRCTRIRDDKDWKSATNLPQLKELYQLSK 833
>gi|11425557 ligase III, DNA, ATP-dependent, isoform alpha [Homo sapiens]
Length = 1009
Score = 164 bits (412), Expect = 2e-39
Identities = 147/571 (25%), Positives = 272/571 (46%), Gaps = 58/571 (10%)
Query: 22 KTRLVADFLKKVPE-DHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEI 80
KT+++ DFL+K D YL + + P + + +K ++K S + ++
Sbjct: 282 KTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDM 341
Query: 81 ENSVKDTGDLGESIALAVKKRKQKSFFSQPL-TIKRVYQTLVKVAETTGEGSQDKKMKYL 139
++ GD+ E+I + ++ K ++ L TI+ V + L+++++ T E Q + ++ +
Sbjct: 342 ARDLEQ-GDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDI 400
Query: 140 ANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISL----AFNVKVELVERAYMLTSD 195
A+ + K I R + ++ + DA+ AF L + + +
Sbjct: 401 ASR---CTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHN 457
Query: 196 FGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARV 255
++ K G V + P++PMLA+ +++ A+ + EIKYDG RV
Sbjct: 458 ---AQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERV 514
Query: 256 QVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPT-----KAIVEGELVAI-GEDGRP 309
QVHK+G+ + +SR L+ V +P V K+ + I++ E++ I + G+P
Sbjct: 515 QVHKNGDHFSYFSRSLKPV---LPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTGKP 571
Query: 310 LPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL-EEIVETN 368
LPF + + + + + L +FD +Y + VSL+D ERRK L + +VE
Sbjct: 572 LPFGTL------GVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIP 625
Query: 369 GKVKIAE-NLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMEN 427
++ +E +TK ++ A+ R ++ G EGL+ K + YEPG R WLK+K N
Sbjct: 626 NRIMFSEMKRVTKALDLADMI-TRVIQEGLEGLVLKDVKGTYEPGKR--HWLKVKKDYLN 682
Query: 428 -------LDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFT 480
DLV++GA +G+G + ++ F++G YDP + ++ V K G D L
Sbjct: 683 EGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQ 742
Query: 481 KMLKPLIIKEEGKRV--WIQ-------------PK--VVIEVTYQEIQKSPKYRS-GFAL 522
L + I ++ ++ W++ PK V E+T E KS + + G ++
Sbjct: 743 NELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISI 802
Query: 523 RFPRYVALREDKGPEDADTIERIAQLYELQE 553
RFPR +R+DK + A + ++ +LY+L +
Sbjct: 803 RFPRCTRIRDDKDWKSATNLPQLKELYQLSK 833
>gi|9627683 J4R [Variola virus] >gi|461948|sp|P33798|DNLI_VARV DNA LIGASE
(POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|419342|pir||C36854 DNA ligase (ATP) (EC 6.5.1.1) -
variola virus >gi|478354|pir||JQ1857 DNA ligase (ATP)
(EC 6.5.1.1) - variola major virus (strains India-1967
and Harvey) >gi|457053|emb|CAA49103.1| (X69198) J4R
[Variola virus] >gi|516403|emb|CAA47545.1| (X67118) DNA
ligase [Variola virus] >gi|745284|prf||2015436GH J4R
gene [Variola major virus]
Length = 552
Score = 164 bits (410), Expect = 3e-39
Identities = 141/556 (25%), Positives = 259/556 (46%), Gaps = 58/556 (10%)
Query: 22 KTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEIE 81
K++L+ DF+ + YLI+ + P D+R + +K +IK S+ K++
Sbjct: 23 KSKLIRDFITDRDDK------YLIIKLLLPGLDDRIYNMNDKQIIKIYSIIFKQSQKDML 76
Query: 82 NSVKDTGDLGESIALAVKKRKQ-KSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKYLA 140
+ G +G++I+ K+ + + LT++ V L ++ T E Q K + +A
Sbjct: 77 QDL-GYGYIGDTISTFFKENTEIRPRNKSILTLEDVDSFLTTLSSITKESHQIKLLTDIA 135
Query: 141 NLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVA 200
++ + K + + ++ + +AIS AY + +
Sbjct: 136 SV---CTCNDLKCVVMLIDKDLKIKAGPRYVLNAIS----------PHAYDVFRKSNNLK 182
Query: 201 KIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKD 260
+I + E L +++ + PI PMLA+ ++ +A + E+KYDG RVQVHK+
Sbjct: 183 EIIENESKQNLDSISVSVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVHKN 242
Query: 261 GEKVTIYSRRLENV-TRAIPEIVEAIKEAL-KPTKAIVEGELVAIGEDGRPLPFQYVLRR 318
+ +SR ++ V + + + E I +A K T +++ E+V + E LPF +
Sbjct: 243 NNEFAFFSRNMKPVLSYKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVQLPFGSLGIH 302
Query: 319 FRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAENL 377
+++Y M L +FD LY DG + D +RR L+++ VE ++ +E
Sbjct: 303 KKKEYKNSNMC------LFVFDCLYFDGFDMTDIPLYKRRSFLKDVMVEIPNRIVFSELT 356
Query: 378 ITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENLDL 430
N + AL EGL+ K ++ VYEPG R +WLKIK ++ DL
Sbjct: 357 NISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKR--RWLKIKRDYLNEGSMADSADL 414
Query: 431 VIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKE 490
V++GA +G+G + ++ F++G YD E+G++ V K SG D+ L L + I +
Sbjct: 415 VVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKC-SGHDDNTLRVLQDQLTMVKINK 473
Query: 491 EGKRV--WI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVALRE 532
+ K++ W+ PK + E++ E S + +G ++RFPR+ +RE
Sbjct: 474 DPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRIRE 533
Query: 533 DKGPEDADTIERIAQL 548
DK +++ + + L
Sbjct: 534 DKTWKESTHLNDLVNL 549
>pir||T28595 DNA ligase (ATP) (EC 6.5.1.1) - variola major virus (strain
Bangladesh 1975) >gi|439074|gb|AAA60905.1| (L22579)
homolog of vaccinia virus CDS A50R (DNA ligase);
putative [Variola major virus]
Length = 552
Score = 164 bits (410), Expect = 3e-39
Identities = 141/556 (25%), Positives = 259/556 (46%), Gaps = 58/556 (10%)
Query: 22 KTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEIE 81
K++L+ DF+ + YLI+ + P D+R + +K +IK S+ K++
Sbjct: 23 KSKLIRDFITDRDDK------YLIIKLLLPGLDDRIYNMNDKQIIKIYSIIFKQSQKDML 76
Query: 82 NSVKDTGDLGESIALAVKKRKQ-KSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKYLA 140
+ G +G++I+ K+ + + LT++ V L ++ T E Q K + +A
Sbjct: 77 QDL-GYGYIGDTISTFFKENTEIRPRNKSILTLEDVDSFLTTLSSITKESHQIKLLTDIA 135
Query: 141 NLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVA 200
++ + K + + ++ + +AIS AY + +
Sbjct: 136 SV---CTCNDLKCVVMLIDKDLKIKAGPRYVLNAIS----------PHAYDVFRKSNNLK 182
Query: 201 KIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKD 260
+I + E L +++ + PI PMLA+ ++ +A + E+KYDG RVQVHK+
Sbjct: 183 EIIENESKQNLNSISVSVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVHKN 242
Query: 261 GEKVTIYSRRLENV-TRAIPEIVEAIKEAL-KPTKAIVEGELVAIGEDGRPLPFQYVLRR 318
+ +SR ++ V + + + E I +A K T +++ E+V + E LPF +
Sbjct: 243 NNEFAFFSRNMKPVLSYKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVQLPFGSLGIH 302
Query: 319 FRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAENL 377
+++Y M L +FD LY DG + D +RR L+++ VE ++ +E
Sbjct: 303 KKKEYKNSNMC------LFVFDCLYFDGFDMTDIPLYKRRSFLKDVMVEIPNRIVFSELT 356
Query: 378 ITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENLDL 430
N + AL EGL+ K ++ VYEPG R +WLKIK ++ DL
Sbjct: 357 NISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKR--RWLKIKRDYLNEGSMADSADL 414
Query: 431 VIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKE 490
V++GA +G+G + ++ F++G YD E+G++ V K SG D+ L L + I +
Sbjct: 415 VVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKC-SGHDDNTLRVLQDQLTMVKINK 473
Query: 491 EGKRV--WI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVALRE 532
+ K++ W+ PK + E++ E S + +G ++RFPR+ +RE
Sbjct: 474 DPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRIRE 533
Query: 533 DKGPEDADTIERIAQL 548
DK +++ + + L
Sbjct: 534 DKTWKESTHLNDLVNL 549
>gi|9633358 K4R protein [variola minor virus] >gi|7514766|pir||A72171 DNA
ligase (ATP) (EC 6.5.1.1) - variola minor virus (strain
Garcia-1966) >gi|5830724|emb|CAB54763.1| (Y16780) K4R
protein [variola minor virus]
Length = 552
Score = 164 bits (410), Expect = 3e-39
Identities = 141/556 (25%), Positives = 259/556 (46%), Gaps = 58/556 (10%)
Query: 22 KTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDSKEIE 81
K++L+ DF+ + YLI+ + P D+R + +K +IK S+ K++
Sbjct: 23 KSKLIRDFITDRDDK------YLIIKLLLPGLDDRIYNMNDKQIIKIYSIIFKQSQKDML 76
Query: 82 NSVKDTGDLGESIALAVKKRKQ-KSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKYLA 140
+ G +G++I+ K+ + + LT++ V L ++ T E Q K + +A
Sbjct: 77 QDL-GYGYIGDTISTYFKENTEIRPRNKSILTLEDVDSFLTTLSSITKESHQIKLLTDIA 135
Query: 141 NLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVA 200
++ + K + + ++ + +AIS AY + +
Sbjct: 136 SV---CTCNDLKCVVMLIDKDLKIKAGPRYVLNAIS----------PHAYDVFRKSNNLK 182
Query: 201 KIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKD 260
+I + E L +++ + PI PMLA+ ++ +A + E+KYDG RVQVHK+
Sbjct: 183 EIIENESKQNLDSISVSVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVHKN 242
Query: 261 GEKVTIYSRRLENV-TRAIPEIVEAIKEAL-KPTKAIVEGELVAIGEDGRPLPFQYVLRR 318
+ +SR ++ V + + + E I +A K T +++ E+V + E LPF +
Sbjct: 243 NNEFAFFSRNMKPVLSYKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVQLPFGSLGIH 302
Query: 319 FRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAENL 377
+++Y M L +FD LY DG + D +RR L+++ VE ++ +E
Sbjct: 303 KKKEYKNSNMC------LFVFDCLYFDGFDMTDIPLYKRRSFLKDVMVEIPNRIVFSELT 356
Query: 378 ITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENLDL 430
N + AL EGL+ K ++ VYEPG R +WLKIK ++ DL
Sbjct: 357 NISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKR--RWLKIKRDYLNEGSMADSADL 414
Query: 431 VIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKE 490
V++GA +G+G + ++ F++G YD E+G++ V K SG D+ L L + I +
Sbjct: 415 VVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKC-SGHDDNTLRVLQDQLTMVKINK 473
Query: 491 EGKRV--WI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVALRE 532
+ K++ W+ PK + E++ E S + +G ++RFPR+ +RE
Sbjct: 474 DPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRIRE 533
Query: 533 DKGPEDADTIERIAQL 548
DK +++ + + L
Sbjct: 534 DKTWKESTHLNDLVNL 549
>pir||S35791 DNA ligase (ATP) (EC 6.5.1.1) - Crithidia fasciculata (fragment)
>gi|312384|emb|CAA80615.1| (Z23078) DNA ligase I
[Crithidia fasciculata]
Length = 334
Score = 162 bits (405), Expect = 1e-38
Identities = 104/322 (32%), Positives = 160/322 (49%), Gaps = 32/322 (9%)
Query: 261 GEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKA---IVEGELVAIG-EDGRPLPFQYVL 316
G I+SR E T P+++ + + I++ E+VA+ E G FQ +
Sbjct: 2 GRGFQIFSRNSETHTGKYPDVISMLPKVFDAAAVHSFIIDSEVVAVNPETGALQAFQVLQ 61
Query: 317 RRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL-EEIVETNGKVKIAE 375
R R+ NI E +IP+ + FD+LY +G + ERR L A
Sbjct: 62 HRGRK--NIAEEDVRIPVCVFAFDILYFNGEPQLGKTLQERRHVLWNAFTPLTAAFAFAT 119
Query: 376 NLITKNVEEAEQFYKRALEMGHEGLMAKRLD--AVYEPGNRGKKWLKIKP-----TMENL 428
+L + NVE+ ++F +++ G EGLM K L+ A Y P R WLK K + L
Sbjct: 120 HLDSDNVEDVQKFLDKSIADGCEGLMVKTLEEQATYTPAKRSHFWLKFKKDYIDGVTDTL 179
Query: 429 DLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII 488
DLV I A +G+G+R + G F+L YDPE E+ + K+G+GF D++L T+ LKP ++
Sbjct: 180 DLVPIAAFYGKGKRTGVFGGFLLACYDPEADEYQSICKIGTGFPDEELERLTQALKPFVV 239
Query: 489 ---------KEEGKRVWIQPKVVIEVTYQEIQKSPKY---------RSGFALRFPRYVAL 530
+++G VW+ V EV ++ SP + G ALRFPRY+
Sbjct: 240 HDKPRYYRAEDDGPDVWLTEAQVWEVKAADLSVSPVHYAAIGLVDLNKGIALRFPRYIRE 299
Query: 531 REDKGPEDADTIERIAQLYELQ 552
R+DK P DA +++A +Y+ Q
Sbjct: 300 RDDKKPADATNAQQVADMYKAQ 321
>gi|11433698 DNA ligase IV [Homo sapiens]
Length = 911
Score = 158 bits (396), Expect = 1e-37
Identities = 157/606 (25%), Positives = 278/606 (44%), Gaps = 79/606 (13%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKK-------VPEDHLE----FIPYLILGDVFP 51
+ +L ++++K+ + K R +FL + ++H + F P + L + P
Sbjct: 16 FADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRL--ILP 73
Query: 52 EWDERELGVG------EKLLIKAVSMAT-GIDSKEIENSVKDTG---DLGESIALAVKKR 101
+ + + G KL I+ +++ G D+ ++ N TG D G+ +A
Sbjct: 74 QLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVL 133
Query: 102 KQKSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGT 161
K + LTI++V L +A +D K L L + +E K++ R ++
Sbjct: 134 KPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKD 193
Query: 162 MRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKP 221
++ GV++ + S+ N EL + +T+D V + + + GL+ ++I +
Sbjct: 194 LKLGVSQQTI---FSVFHNDAAEL----HNVTTDLEKVCRQLH-DPSVGLSDISITLFSA 245
Query: 222 IKPMLAQQAANIKEALLEMGGEAEF-EIKYDGARVQVHKDGEKVTIYSRRLENVTRAI-- 278
KPMLA A+I+ +M ++ + E K DG R+Q+HKDG+ +SR N T
Sbjct: 246 FKPMLAA-IADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGA 304
Query: 279 --------PEIVEAIKEALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMME 330
P I A K ++ I++GE++A P + K++I+ M+E
Sbjct: 305 SPTEGSLTPFIHNAFKADIQI--CILDGEMMAYN------PNTQTFMQKGTKFDIKRMVE 356
Query: 331 KIPLELN--LFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAENLITKNVEEAEQ 387
L+ +FDVL V+ L +R + L I G+++I + E
Sbjct: 357 DSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVID 416
Query: 388 FYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKP-----TMENLDLVIIGAEWGEGRR 442
A++ EG+M K+ ++Y+P RG+ WLKIKP M+ LD++I+G WG+G R
Sbjct: 417 ALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSR 476
Query: 443 AHLLGSFILG-AYDPETGE----FLEVGKVGSGFTDDDL----VEFTKMLKP-------- 485
++ F+ A P GE F + +VGSG T +L ++ K KP
Sbjct: 477 GGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPS 536
Query: 486 -LIIKEEGKRVWIQP--KVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDADTI 542
++ E V+I+P V++++ EI S Y++G LRFPR +R+DK + T+
Sbjct: 537 SILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTL 596
Query: 543 ERIAQL 548
+ + QL
Sbjct: 597 DDLEQL 602
>gi|4504997 DNA ligase IV [Homo sapiens] >gi|1706482|sp|P49917|DNL4_HUMAN DNA
LIGASE IV (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|7512395|pir||I37079 DNA ligase (ATP) (EC 6.5.1.1) IV
- human >gi|860937|emb|CAA58467.1| (X83441) DNA ligase
IV [Homo sapiens]
Length = 844
Score = 155 bits (389), Expect = 9e-37
Identities = 147/549 (26%), Positives = 254/549 (45%), Gaps = 66/549 (12%)
Query: 49 VFPEWDERELGVG------EKLLIKAVSMAT-GIDSKEIENSVKDTG---DLGESIALAV 98
+ P+ + + G KL I+ +++ G D+ ++ N TG D G+ +A
Sbjct: 4 ILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAY 63
Query: 99 KKRKQKSFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTV 158
K + LTI++V L +A +D K L L + +E K++ R +
Sbjct: 64 FVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMI 123
Query: 159 LGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQI 218
+ ++ GV++ + S+ N EL + +T+D V + + + GL+ ++I +
Sbjct: 124 IKDLKLGVSQQTI---FSVFHNDAAEL----HNVTTDLEKVCRQLH-DPSVGLSDISITL 175
Query: 219 GKPIKPMLAQQAANIKEALLEMGGEAEF-EIKYDGARVQVHKDGEKVTIYSRRLENVTRA 277
KPMLA A+I+ +M ++ + E K DG R+Q+HKDG+ +SR N T
Sbjct: 176 FSASKPMLAA-IADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQ 234
Query: 278 I----------PEIVEAIKEALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEE 327
P I A K ++ I++GE++A P + K++I+
Sbjct: 235 FGASPTEGSLTPFIHNAFKADIQI--CILDGEMMAYN------PNTQTFMQKGTKFDIKR 286
Query: 328 MMEKIPLELN--LFDVLYVDGVSLIDTKFMERRKKLEEI-VETNGKVKIAENLITKNVEE 384
M+E L+ +FDVL V+ L +R + L I G+++I + E
Sbjct: 287 MVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNE 346
Query: 385 AEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKP-----TMENLDLVIIGAEWGE 439
A++ EG+M K+ ++Y+P RG+ WLKIKP M+ LD++I+G WG+
Sbjct: 347 VIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGK 406
Query: 440 GRRAHLLGSFILG-AYDPETGE----FLEVGKVGSGFTDDDL----VEFTKMLKP----- 485
G R ++ F+ A P GE F + +VGSG T +L ++ K KP
Sbjct: 407 GSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKA 466
Query: 486 ----LIIKEEGKRVWIQP--KVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPEDA 539
++ E V+I+P V++++ EI S Y++G LRFPR +R+DK +
Sbjct: 467 PPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHEC 526
Query: 540 DTIERIAQL 548
T++ + QL
Sbjct: 527 MTLDDLEQL 535
>gb|AAC53003.1| (U66057) DNA ligase III-beta [Mus musculus]
Length = 956
Score = 154 bits (386), Expect = 2e-36
Identities = 146/579 (25%), Positives = 266/579 (45%), Gaps = 71/579 (12%)
Query: 22 KTRLVADFLKKVPE----DHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDS 77
KT+++ DFL+K D YL + + P + + +K ++K S +
Sbjct: 284 KTQIIHDFLQKGSTGSTGDGFHGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNP 343
Query: 78 KEIENSVKDTGDLGESIALAVKKRKQKSFFSQPL-TIKRVYQTLVKVAETTGEGSQDKKM 136
++ ++ GD+ E+I + ++ K ++ L TI+ V L+ +++ T E Q + +
Sbjct: 344 DDMARDLEQ-GDVSETIRIFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQAL 402
Query: 137 KYLAN---------LFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVE 187
+ +A+ + + ++ A+ VL + E A + N++ ++VE
Sbjct: 403 QDIASRCTANDLKCIRLIKHDLKMNSGAKHVLDALDPNAYE-----AFKASRNLQ-DVVE 456
Query: 188 RAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFE 247
R + + K G +V + P++PMLA+ +I+ A+ + E
Sbjct: 457 RVLHNEQE------VEKDPGRRRALRVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSE 510
Query: 248 IKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPT-----KAIVEGELVA 302
IKYDG RVQVHK G+ + +SR L+ V +P V K+ + I++ E++
Sbjct: 511 IKYDGERVQVHKKGDHFSYFSRSLKPV---LPHKVAHFKDYIPKAFPGGQSMILDSEVLL 567
Query: 303 IGED-GRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL 361
I + G+PLPF + + + + L L +FD +Y + VSL+D ERRK L
Sbjct: 568 IDNNTGKPLPFGTL------GVHKKAAFQDANLCLFVFDCIYFNDVSLMDRPLCERRKFL 621
Query: 362 -EEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
+ +VE ++ +E + R + G EGL+ K + YEPG R WLK
Sbjct: 622 HDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKR--HWLK 679
Query: 421 IKPTMEN-------LDLVIIGAEW-GEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFT 472
+K N DLV++G G+G + ++ F++G YDP++ ++ V K G
Sbjct: 680 VKKDYLNEGAMADTADLVVLGVFLIGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHD 739
Query: 473 DDDLVEFTKMLKPLIIKEEGKRV--WIQ-------------PK--VVIEVTYQEIQKSPK 515
D L K L + I ++ ++ W++ PK V E+T E +S
Sbjct: 740 DATLARLQKELVMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEA 799
Query: 516 YRS-GFALRFPRYVALREDKGPEDADTIERIAQLYELQE 553
+ + G ++RFPR +R+DK + A + ++ +LY+L +
Sbjct: 800 HTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSK 838
>gi|6754546 ligase III, DNA, ATP-dependent [Mus musculus]
>gi|3913496|sp|P97386|DNL3_MOUSE DNA LIGASE III
(POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
>gi|1794223|gb|AAC53004.1| (U66058) DNA ligase III-alpha
[Mus musculus]
Length = 1015
Score = 154 bits (386), Expect = 2e-36
Identities = 146/579 (25%), Positives = 266/579 (45%), Gaps = 71/579 (12%)
Query: 22 KTRLVADFLKKVPE----DHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVSMATGIDS 77
KT+++ DFL+K D YL + + P + + +K ++K S +
Sbjct: 284 KTQIIHDFLQKGSTGSTGDGFHGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNP 343
Query: 78 KEIENSVKDTGDLGESIALAVKKRKQKSFFSQPL-TIKRVYQTLVKVAETTGEGSQDKKM 136
++ ++ GD+ E+I + ++ K ++ L TI+ V L+ +++ T E Q + +
Sbjct: 344 DDMARDLEQ-GDVSETIRIFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQAL 402
Query: 137 KYLAN---------LFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVE 187
+ +A+ + + ++ A+ VL + E A + N++ ++VE
Sbjct: 403 QDIASRCTANDLKCIRLIKHDLKMNSGAKHVLDALDPNAYE-----AFKASRNLQ-DVVE 456
Query: 188 RAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFE 247
R + + K G +V + P++PMLA+ +I+ A+ + E
Sbjct: 457 RVLHNEQE------VEKDPGRRRALRVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSE 510
Query: 248 IKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPT-----KAIVEGELVA 302
IKYDG RVQVHK G+ + +SR L+ V +P V K+ + I++ E++
Sbjct: 511 IKYDGERVQVHKKGDHFSYFSRSLKPV---LPHKVAHFKDYIPKAFPGGQSMILDSEVLL 567
Query: 303 IGED-GRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL 361
I + G+PLPF + + + + L L +FD +Y + VSL+D ERRK L
Sbjct: 568 IDNNTGKPLPFGTL------GVHKKAAFQDANLCLFVFDCIYFNDVSLMDRPLCERRKFL 621
Query: 362 -EEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLK 420
+ +VE ++ +E + R + G EGL+ K + YEPG R WLK
Sbjct: 622 HDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKR--HWLK 679
Query: 421 IKPTMEN-------LDLVIIGAEW-GEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFT 472
+K N DLV++G G+G + ++ F++G YDP++ ++ V K G
Sbjct: 680 VKKDYLNEGAMADTADLVVLGVFLIGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHD 739
Query: 473 DDDLVEFTKMLKPLIIKEEGKRV--WIQ-------------PK--VVIEVTYQEIQKSPK 515
D L K L + I ++ ++ W++ PK V E+T E +S
Sbjct: 740 DATLARLQKELVMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEA 799
Query: 516 YRS-GFALRFPRYVALREDKGPEDADTIERIAQLYELQE 553
+ + G ++RFPR +R+DK + A + ++ +LY+L +
Sbjct: 800 HTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSK 838
>gi|9633769 m133R [Myxoma virus] >gi|6523988|gb|AAF15021.1|AF170726_137
(AF170726) m133R [Myxoma virus]
Length = 563
Score = 152 bits (381), Expect = 8e-36
Identities = 154/571 (26%), Positives = 248/571 (42%), Gaps = 78/571 (13%)
Query: 20 LIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERELGVGEKLLIKAVS--------- 70
L KT+ + +F+++ D YLI+ + P R + + L+K S
Sbjct: 28 LEKTKAIEEFIRRYDTD----TQYLIVKMLLPSLCNRVYRLNDVQLVKLFSKLFKKDVKS 83
Query: 71 MATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQTLVKVAETTGEG 130
M T ++ + ++K+ + ES +KK LT+ V L + T E
Sbjct: 84 MLTDLEKGYVAVTIKEFFESSESFIKPIKK--------SILTLNDVDSFLAHLTTLTKEK 135
Query: 131 SQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAY 190
Q +L + + + K + ++ + +A+ AY
Sbjct: 136 DQ---AHFLGRIASVSTGNDLKCFILFIKNDLQIKAGTKCVLNALGA----------EAY 182
Query: 191 MLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKY 250
L + KI N+ V+ G P+KPMLA ++ A+ + EIKY
Sbjct: 183 TLFKTSQDLKKIVYHVLNESSDDVSTGPGTPVKPMLADICRSVSVAVNKYKRGIYAEIKY 242
Query: 251 DGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEAL-----KPTKAIVEGELVAIGE 305
DG RVQ+HK YSR L+ VT P V+ + +AL I++ ELV + E
Sbjct: 243 DGERVQIHKYDNIYEFYSRNLKRVT---PHKVQGLDDALSIAFPSANNFILDAELVLVDE 299
Query: 306 -DGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEI 364
G LPF + +K + E L +FD LY + SL+ F++RR +E +
Sbjct: 300 RTGECLPFGSL--GVHKKASFESSTPC----LFVFDCLYYNDKSLLRVPFVQRRAFIEAM 353
Query: 365 V-ETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK- 422
+ E K+ +++ I +N + + + ++E G EGLM K D VY+PG RG WLKIK
Sbjct: 354 IKEIKHKITMSDIRIIRNESDITEALQESVEKGLEGLMLKGGDDVYKPGLRG--WLKIKK 411
Query: 423 -------PTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDD 475
++ DLV++GA +G+G + ++ F++G YD E + V K SG TD
Sbjct: 412 DHLKTATSMADSADLVVLGAYYGKGCKGGIMSVFLMGCYDEEKDNWKTVTKC-SGHTDKT 470
Query: 476 LVEFTKMLKPLIIKEEGK-RVWI------QPKVVI---------EVTYQEIQKSPKY-RS 518
L E M I K+ K W+ P V+ E++ SP + +
Sbjct: 471 LQELQSMDVIKIGKDPAKIPDWLIVHKTYYPDFVVRDPTKAPVWEISGASFSSSPNHTAN 530
Query: 519 GFALRFPRYVALREDKGPEDADTIERIAQLY 549
G ++RFPR +R+DK DA T+ + LY
Sbjct: 531 GISIRFPRCTKIRDDKSWRDATTLRELTTLY 561
>gb|AAF54801.1| (AE003695) CG17227 gene product [Drosophila melanogaster]
Length = 734
Score = 144 bits (360), Expect = 2e-33
Identities = 141/545 (25%), Positives = 238/545 (42%), Gaps = 64/545 (11%)
Query: 49 VFPEWDERELGVGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESI----ALAVKKRKQK 104
+ P ++R + K LIK S D +++ ++ GD+ E++ A + K + QK
Sbjct: 60 LIPAANQRVYNLQNKALIKLFSRIFNADQQQMHLDLEQ-GDVSETLRKHFAASKKLKPQK 118
Query: 105 SFFSQPLTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRT 164
L ++ V + L+ + E T E D++ L L A ++ + R V +R
Sbjct: 119 Q---SKLYLQEVEEMLLHLVERTKE---DEQTDLLQKLCSKATDLDLRTFIRLVKHDLRI 172
Query: 165 GVAEGLLRDAIS-------LAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQ 217
+ DA + V +VE+ + + + KT+ A IQ
Sbjct: 173 NARARHILDAFGPDAYPAYQSSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSA---IQ 229
Query: 218 IGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRA 277
+ PI PMLA ++++A + EIKYDG RVQ+HK G +SR L+ V
Sbjct: 230 VMTPISPMLASPCKSVEDAFKKSPTGLYSEIKYDGERVQIHKQGNDFKFFSRNLKPV--- 286
Query: 278 IPEIVEAIKEALKPT-----KAIVEGELVAIGED-GRPLPFQYVLRRFRRKYNIEEMMEK 331
+ + A+K+ + + I++ E++ + D G LPF + ++ +
Sbjct: 287 VDHKIRALKKYIPQAFPGGGEMILDSEIILVDTDTGALLPFGSLGAHKKQTF------AN 340
Query: 332 IPLELNLFDVLYVDGVSLIDTKFMERRKKLEEIVE-TNGKVKIAENLITKNVEEAEQFYK 390
+ L +FD + DG L F +RR+ LE+ ++ V+++E+ K E
Sbjct: 341 AAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIKSHVQLSESEFLKTTRELAAMTA 400
Query: 391 RALEMGHEGLMAKRLDAVYEPGNRGKKWLKIK-------PTMENLDLVIIGAEWGEGRRA 443
R L EG++ K + Y+PG R WLK+K + DLV++GA +G G++
Sbjct: 401 RVLHANLEGVVLKSPTSTYQPGKR--NWLKVKKDYLFDGKMADTADLVVLGAWYGSGKKG 458
Query: 444 HLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKRV--W----- 496
L F++G YD + V KV SG D E K L L + + + W
Sbjct: 459 GTLSIFLMGCYDAFGRLWKTVTKVHSGLDDATNAEVHKSLIKLTERADANAIPSWLLCSK 518
Query: 497 -IQPKV---------VIEVTYQEIQKSPKY-RSGFALRFPRYVALREDKGPEDADTIERI 545
+ P V V E+T E KS + SG ++RFPR R DK ++A+ + +
Sbjct: 519 SLVPDVLAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSDKSAKEANDLAHL 578
Query: 546 AQLYE 550
L+E
Sbjct: 579 EDLFE 583
>gb|AAF91284.1|AF233527_1 (AF233527) DNA ligase IV [Arabidopsis thaliana]
Length = 1219
Score = 141 bits (353), Expect = 1e-32
Identities = 147/617 (23%), Positives = 273/617 (43%), Gaps = 100/617 (16%)
Query: 4 IELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERE--LGVG 61
+ L QK + ++ K K R D K P D+ + +I P D G+
Sbjct: 11 VSLFNWIQKSKTSSQKRSKFRKFLDTYCK-PSDYFVAVRLII-----PSLDRERGSYGLK 64
Query: 62 EKLLIKAVSMATGIDSKEIENSVK-------DTGDLGES------IALAVKKRKQKSFFS 108
E +L + A GI S++ ++V+ T G + IA V +R+Q S
Sbjct: 65 ESVLATCLIDALGI-SRDAPDAVRLLNWRKGGTAKAGANAGNFSLIAAEVLQRRQ-GMAS 122
Query: 109 QPLTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAE 168
LTIK + L ++A + +K L+ L E K++ R +L ++ G++E
Sbjct: 123 GGLTIKELNDLLDRLASSENRA---EKTLVLSTLIQKTNAQEMKWVIRIILKDLKLGMSE 179
Query: 169 GLLRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQ 228
+I F+ E + + +T D V + + + + + I++GK ++P LA
Sbjct: 180 ----KSIFQEFHPDAEDL---FNVTCDLKLVCEKLR-DRHQRHKRQDIEVGKAVRPQLAM 231
Query: 229 QAANIKEALLEMGG-EAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKE 287
+ ++ A ++ G + E K+DG R+Q+HK+G + +SR + + + + I +
Sbjct: 232 RIGDVNAAWKKLHGKDVVAECKFDGDRIQIHKNGTDIHYFSRNFLDHSEYAHAMSDLIVQ 291
Query: 288 ALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELN--------LF 339
+ K I++GE+ L + L RF + +E+ + L+ F
Sbjct: 292 NILVDKCILDGEM---------LVWDTSLNRFAEFGSNQEIAKAAREGLDSHKQLCYVAF 342
Query: 340 DVLYVDGVSLIDTKFMERRKKLEEIVET-NGKVKI----------------AENLITKNV 382
DVLYV S+I ER + L+++V+ G++++ + +++
Sbjct: 343 DVLYVGDTSVIHQSLKERHELLKKVVKPLKGRLEVLVPEGGLNVHRPSGEPSWSIVVHAA 402
Query: 383 EEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTM----ENLDLVIIGAEWG 438
+ E+F+K +E EG++ K L++ +EPG+R KW+K+KP +LD++IIG +G
Sbjct: 403 ADVERFFKETVENRDEGIVLKDLESKWEPGDRSGKWMKLKPEYIRAGADLDVLIIGGYYG 462
Query: 439 EGRRAHLLGSFILGAYDPETG-----EFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGK 493
GRR + F++ D F+ +VG+G +DD+L LKP K E
Sbjct: 463 SGRRGGEVAQFLVALADRAEANVYPRRFMSFCRVGTGLSDDELNTVVSKLKPYFRKNEHP 522
Query: 494 R------------------VWI---QPKVVIEVTYQ-EIQKSPKYRSGFALRFPRYVALR 531
+ VWI + +++ +T +S + + ++LRFPR +R
Sbjct: 523 KKAPPSFYQVTNHSKERPDVWIDSPEKSIILSITSDIRTIRSEVFVAPYSLRFPRIDKVR 582
Query: 532 EDKGPEDADTIERIAQL 548
DK + ++ +L
Sbjct: 583 YDKPWHECLDVQAFVEL 599
>gb|AAA67138.1| (U00761) ATP-dependent DNA ligase [Rabbit fibroma virus]
Length = 559
Score = 137 bits (342), Expect = 3e-31
Identities = 117/374 (31%), Positives = 178/374 (47%), Gaps = 44/374 (11%)
Query: 208 NDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIY 267
N+ +V+ G P+KPMLA ++ + + EIKYDG RVQ+HK + Y
Sbjct: 196 NESSDEVSTGPGTPVKPMLADICRSVSTIVNKYKRGIYAEIKYDGERVQIHKYDDVYEFY 255
Query: 268 SRRLENVTRAIPEIVEAIKEAL-----KPTKAIVEGELVAIGE-DGRPLPFQYVLRRFRR 321
SR L VT P V+ + EAL I++ ELV + E G LPF + +
Sbjct: 256 SRNLRPVT---PHKVQGLDEALSIAFPSANNFILDAELVLVDEHTGECLPFGSLGVHKKA 312
Query: 322 KYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLE-EIVETNGKVKIAENLITK 380
+ L +FD L+ + SL+ F++RR +E I E K+ +++ +
Sbjct: 313 SFKSSTPC------LFVFDCLFYNDKSLLRVPFVQRRAFVETTIKEIKHKIVLSDIRTIR 366
Query: 381 NVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKP-------TM-ENLDLVI 432
+ + + ++E G EGLM K D VY+PG RG WLKIK TM ++ DLV+
Sbjct: 367 SESDITEALNESVEKGLEGLMLKGGDDVYKPGLRG--WLKIKKDHLKTPITMADSADLVV 424
Query: 433 IGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEG 492
+GA +G+G + ++ F++G YD E + V K SG TD L E M I K+
Sbjct: 425 LGAYYGKGCKGGIMAVFLMGCYDEEDDNWKTVTKC-SGHTDKMLQELQSMDVVKIGKDPS 483
Query: 493 K-RVWI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVALREDKG 535
K W+ PK V E++ SP + +G ++RFPR +R+DK
Sbjct: 484 KIPDWLIVNKTYYPDFVVKDPKKAPVWEISGASFSSSPNHTANGISIRFPRCTKIRDDKS 543
Query: 536 PEDADTIERIAQLY 549
DA ++ + LY
Sbjct: 544 WRDATSLRELTALY 557
>gi|9633943 gp133R [Rabbit fibroma virus]
>gi|6578662|gb|AAF18016.1|AF170722_134 (AF170722) gp133R
[Rabbit fibroma virus]
Length = 559
Score = 137 bits (342), Expect = 3e-31
Identities = 117/374 (31%), Positives = 178/374 (47%), Gaps = 44/374 (11%)
Query: 208 NDGLAKVTIQIGKPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIY 267
N+ +V+ G P+KPMLA ++ + + EIKYDG RVQ+HK + Y
Sbjct: 196 NESSDEVSTGPGTPVKPMLADICRSVSTIVNKYKRGIYAEIKYDGERVQIHKYDDVYEFY 255
Query: 268 SRRLENVTRAIPEIVEAIKEAL-----KPTKAIVEGELVAIGE-DGRPLPFQYVLRRFRR 321
SR L VT P V+ + EAL I++ ELV + E G LPF + +
Sbjct: 256 SRNLRPVT---PHKVQGLDEALSIAFPSANNFILDAELVLVDEHTGECLPFGSLGVHKKA 312
Query: 322 KYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLE-EIVETNGKVKIAENLITK 380
+ L +FD L+ + SL+ F++RR +E I E K+ +++ +
Sbjct: 313 SFKSSTPC------LFVFDCLFYNDKSLLRVPFVQRRAFVETTIKEIKHKIVLSDIRTIR 366
Query: 381 NVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKP-------TM-ENLDLVI 432
+ + + ++E G EGLM K D VY+PG RG WLKIK TM ++ DLV+
Sbjct: 367 SESDITEALNESVEKGLEGLMLKGGDDVYKPGLRG--WLKIKKDHLKTPITMADSADLVV 424
Query: 433 IGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEG 492
+GA +G+G + ++ F++G YD E + V K SG TD L E M I K+
Sbjct: 425 LGAYYGKGCKGGIMAVFLMGCYDEEDDNWKTVTKC-SGHTDKMLQELQSMDVVKIGKDPS 483
Query: 493 K-RVWI-------------QPK--VVIEVTYQEIQKSPKY-RSGFALRFPRYVALREDKG 535
K W+ PK V E++ SP + +G ++RFPR +R+DK
Sbjct: 484 KIPDWLIVNKTYYPDFVVKDPKKAPVWEISGASFSSSPNHTANGISIRFPRCTKIRDDKS 543
Query: 536 PEDADTIERIAQLY 549
DA ++ + LY
Sbjct: 544 WRDATSLRELTALY 557
>emb|CAA21085.2| (AL031740) dna ligase [Schizosaccharomyces pombe]
Length = 923
Score = 127 bits (316), Expect = 3e-28
Identities = 132/556 (23%), Positives = 246/556 (43%), Gaps = 68/556 (12%)
Query: 56 RELGVGEKLLIKAVSMA-TGIDSKEIEN----SVKDTGDLGESIALAVKKRKQKSFFSQP 110
+E G+G KL I+A+ ++ T D+K ++N K TGD + +++R ++F
Sbjct: 93 KEFGLG-KLFIRAMHLSPTSEDAKSLKNWRGSESKHTGDFSTMLQDILQRRAYRTF-PGA 150
Query: 111 LTIKRVYQTLVKVAETTGEGS----------QDKKMKYLANLFMDAEPIEAKYIARTVLG 160
T+ V L ++A+ + E +D ++ L + P+E +++ +L
Sbjct: 151 FTVGDVNALLDQLADASSEYVLNFLPYLTLIRDTRVNILEQFYRSLSPLELRWLIPILLK 210
Query: 161 TMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVA-KIAKTEGNDGLAKVTIQIG 219
+ G +E + +V R Y L S + ++ + + +++
Sbjct: 211 VRKYGTSEKFI-------LSVFHPDAARLYRLCSSLKRICWELYDPSRSLDETETDVEVF 263
Query: 220 KPIKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVHKDGEKVTIYSRRLENVTRA 277
+P LA LE G F E K DG R+Q+H K YSR + T A
Sbjct: 264 SCFQPQLANFKKKDLHQTLEAMGNKPFWIEEKLDGERIQLHMSSGKFQFYSRNARSYTYA 323
Query: 278 IPEIVEAIKEALKPTKAIV---EGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPL 334
E + T+ I+ + + I DG + + VL ++ + E
Sbjct: 324 YGS--SYFDEQSRLTQYIIGAFDKRISQIILDGEMVTWDPVLETVIPYGSLRSIFEDSSS 381
Query: 335 ELN------LFDVLYVDGVSLIDTKFMERRKKLEE-IVETNGKVKIAENLITKNVEEAEQ 387
+ +FD+LY++G SL+ RR+ LE+ IV + ++ I + +E+ E
Sbjct: 382 HSSYSPYYVVFDILYLNGKSLVKYSLESRRRILEKVIVRESHRMSILPYKVGSTIEDIEA 441
Query: 388 FYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRR 442
+ ++ G EGL+ K+ Y G R W+K+KP E+LD +I+G +G G++
Sbjct: 442 ELRNVIQEGSEGLVIKKPSGSYHLGERMDDWIKVKPYYLQGFGEDLDCLILGGYFGRGKQ 501
Query: 443 AHLLGSFILGA---YDPE--TGEFLEVGKVGSGFT--DDDLV-------------EFTKM 482
+ + SF+ G Y P+ + +F +VG GFT D D++ + +
Sbjct: 502 SGKINSFLCGLRMDYTPKDHSEKFQSFVRVGGGFTYFDRDIIRKETEGKWLPWSSDALEY 561
Query: 483 LKPLIIKEEGKR--VWIQPK--VVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPED 538
++ K++ ++ +WI PK +V+++ E+ S ++++ + LRFPR +R D+ +D
Sbjct: 562 MELAGTKQDFEKPDMWIHPKDSLVLQIKAAEVVVSNRFKTNYTLRFPRLEKVRLDRSWKD 621
Query: 539 ADTIERIAQLYELQER 554
A TI L E+
Sbjct: 622 ALTINEFFTLKNAVEK 637
>pir||T40845 dna ligase - fission yeast (Schizosaccharomyces pombe)
Length = 871
Score = 127 bits (316), Expect = 3e-28
Identities = 132/556 (23%), Positives = 246/556 (43%), Gaps = 68/556 (12%)
Query: 56 RELGVGEKLLIKAVSMA-TGIDSKEIEN----SVKDTGDLGESIALAVKKRKQKSFFSQP 110
+E G+G KL I+A+ ++ T D+K ++N K TGD + +++R ++F
Sbjct: 93 KEFGLG-KLFIRAMHLSPTSEDAKSLKNWRGSESKHTGDFSTMLQDILQRRAYRTF-PGA 150
Query: 111 LTIKRVYQTLVKVAETTGEGS----------QDKKMKYLANLFMDAEPIEAKYIARTVLG 160
T+ V L ++A+ + E +D ++ L + P+E +++ +L
Sbjct: 151 FTVGDVNALLDQLADASSEYVLNFLPYLTLIRDTRVNILEQFYRSLSPLELRWLIPILLK 210
Query: 161 TMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVA-KIAKTEGNDGLAKVTIQIG 219
+ G +E + +V R Y L S + ++ + + +++
Sbjct: 211 VRKYGTSEKFI-------LSVFHPDAARLYRLCSSLKRICWELYDPSRSLDETETDVEVF 263
Query: 220 KPIKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVHKDGEKVTIYSRRLENVTRA 277
+P LA LE G F E K DG R+Q+H K YSR + T A
Sbjct: 264 SCFQPQLANFKKKDLHQTLEAMGNKPFWIEEKLDGERIQLHMSSGKFQFYSRNARSYTYA 323
Query: 278 IPEIVEAIKEALKPTKAIV---EGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPL 334
E + T+ I+ + + I DG + + VL ++ + E
Sbjct: 324 YGS--SYFDEQSRLTQYIIGAFDKRISQIILDGEMVTWDPVLETVIPYGSLRSIFEDSSS 381
Query: 335 ELN------LFDVLYVDGVSLIDTKFMERRKKLEE-IVETNGKVKIAENLITKNVEEAEQ 387
+ +FD+LY++G SL+ RR+ LE+ IV + ++ I + +E+ E
Sbjct: 382 HSSYSPYYVVFDILYLNGKSLVKYSLESRRRILEKVIVRESHRMSILPYKVGSTIEDIEA 441
Query: 388 FYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRR 442
+ ++ G EGL+ K+ Y G R W+K+KP E+LD +I+G +G G++
Sbjct: 442 ELRNVIQEGSEGLVIKKPSGSYHLGERMDDWIKVKPYYLQGFGEDLDCLILGGYFGRGKQ 501
Query: 443 AHLLGSFILGA---YDPE--TGEFLEVGKVGSGFT--DDDLV-------------EFTKM 482
+ + SF+ G Y P+ + +F +VG GFT D D++ + +
Sbjct: 502 SGKINSFLCGLRMDYTPKDHSEKFQSFVRVGGGFTYFDRDIIRKETEGKWLPWSSDALEY 561
Query: 483 LKPLIIKEEGKR--VWIQPK--VVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPED 538
++ K++ ++ +WI PK +V+++ E+ S ++++ + LRFPR +R D+ +D
Sbjct: 562 MELAGTKQDFEKPDMWIHPKDSLVLQIKAAEVVVSNRFKTNYTLRFPRLEKVRLDRSWKD 621
Query: 539 ADTIERIAQLYELQER 554
A TI L E+
Sbjct: 622 ALTINEFFTLKNAVEK 637
>dbj|BAA97366.1| (AB023042) contains similarity to DNA ligase~gene_id:MUL3.11
[Arabidopsis thaliana]
Length = 1184
Score = 127 bits (315), Expect = 4e-28
Identities = 140/609 (22%), Positives = 265/609 (42%), Gaps = 106/609 (17%)
Query: 4 IELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDHLEFIPYLILGDVFPEWDERE--LGVG 61
+ L QK + ++ K K R D K P D+ + +I P D G+
Sbjct: 11 VSLFNWIQKSKTSSQKRSKFRKFLDTYCK-PSDYFVAVRLII-----PSLDRERGSYGLK 64
Query: 62 EKLLIKAVSMATGIDSKEIENSVK-------DTGDLGES------IALAVKKRKQKSFFS 108
E +L + A GI S++ ++V+ T G + IA V +R+Q S
Sbjct: 65 ESVLATCLIDALGI-SRDAPDAVRLLNWRKGGTAKAGANAGNFSLIAAEVLQRRQ-GMAS 122
Query: 109 QPLTIKRVYQTLVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAE 168
LTIK + L ++A + +K L+ L E K++ R +L ++ G++E
Sbjct: 123 GGLTIKELNDLLDRLASSENRA---EKTLVLSTLIQKTNAQEMKWVIRIILKDLKLGMSE 179
Query: 169 GLLRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGNDGLAKVTIQIGKPIKPMLAQ 228
+I F+ E + + +T D V + + + + + I++GK ++P LA
Sbjct: 180 ----KSIFQEFHPDAEDL---FNVTCDLKLVCEKLR-DRHQRHKRQDIEVGKAVRPQLAM 231
Query: 229 QAANIKEALLEMGG-EAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKE 287
+ ++ A ++ G + E K+DG R+Q+HK+G + +SR + + + + I +
Sbjct: 232 RIGDVNAAWKKLHGKDVVAECKFDGDRIQIHKNGTDIHYFSRNFLDHSEYAHAMSDLIVQ 291
Query: 288 ALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGV 347
+ K I++GE+ L + L RF + +E+ + L
Sbjct: 292 NILVDKCILDGEM---------LVWDTSLNRFAEFGSNQEIAKAAREGL----------- 331
Query: 348 SLIDTKFMERRKKLEEIVET-NGKVKI----------------AENLITKNVEEAEQFYK 390
D+ ER + L+++V+ G++++ + +++ + E+F+K
Sbjct: 332 ---DSHKQERHELLKKVVKPLKGRLEVLVPEGGLNVHRPSGEPSWSIVVHAAADVERFFK 388
Query: 391 RALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTM----ENLDLVIIGAEWGEGRRAHLL 446
+E EG++ K L++ +EPG+R KW+K+KP +LD++IIG +G GRR +
Sbjct: 389 ETVENRDEGIVLKDLESKWEPGDRSGKWMKLKPEYIRAGADLDVLIIGGYYGSGRRGGEV 448
Query: 447 GSFILGAYDPETG-----EFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKR------- 494
F++ D F+ +VG+G +DD+L LKP K E +
Sbjct: 449 AQFLVALADRAEANVYPRRFMSFCRVGTGLSDDELNTVVSKLKPYFRKNEHPKKAPPSFY 508
Query: 495 -----------VWI---QPKVVIEVTYQ-EIQKSPKYRSGFALRFPRYVALREDKGPEDA 539
VWI + +++ +T +S + + ++LRFPR +R DK +
Sbjct: 509 QVTNHSKERPDVWIDSPEKSIILSITSDIRTIRSEVFVAPYSLRFPRIDKVRYDKPWHEC 568
Query: 540 DTIERIAQL 548
++ +L
Sbjct: 569 LDVQAFVEL 577
>gi|9630988 DNA ligase [Lymantria dispar nucleopolyhedrovirus]
>gi|7460530|pir||T30369 DNA ligase-like protein -
Lymantria dispar nuclear polyhedrosis virus
>gi|3822256|gb|AAC70207.1|AAC70207 (AF081810) DNA ligase
[Lymantria dispar nucleopolyhedrovirus]
Length = 548
Score = 127 bits (315), Expect = 4e-28
Identities = 102/367 (27%), Positives = 165/367 (44%), Gaps = 56/367 (15%)
Query: 220 KPIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRL-------- 271
KP+ P LAQ + L++ A E+KYDG RVQVHK G + +SR L
Sbjct: 169 KPVPPALAQPCRRLASVLVKHPEGALAEVKYDGERVQVHKAGSRFKFFSRTLKPVPEHKV 228
Query: 272 ----ENVTRAIPEIVEAIKEALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYNIEE 327
E++TRA P + I++ E+V + G LPF + R + ++
Sbjct: 229 AGCREHLTRAFP----------RARNFILDAEIVMVDGSGEALPFGTLGRLKQMEHADGH 278
Query: 328 MMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKL--EEIVETNGKVKIAENLITKNVEEA 385
+ + +FD L +GVS ++ ++ R+++ +EIV G+V ++ T + E
Sbjct: 279 VC------MYIFDCLRYNGVSYLNATPLDFRRRVLQDEIVPIEGRVVLSAMERTNTLSEL 332
Query: 386 EQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPT-------MENLDLVIIGAEWG 438
+F R L G EG++ K + Y P R W K+K ++ LDLV++GA +G
Sbjct: 333 RRFVHRTLATGAEGVVLKGRLSSYAPNKRD--WFKMKKEHLCDGALVDTLDLVVLGAYYG 390
Query: 439 EGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLI-IKEEGKRVWI 497
GR + F++G D E+ + V KV SG D L +K L+PL+ + W
Sbjct: 391 TGRNCRKMSVFLMGCLDRESNVWTTVTKVHSGLADAALTALSKELRPLMAAPRDDLPEWF 450
Query: 498 ---------------QPKVVIEVTYQEIQKS-PKYRSGFALRFPRYVALREDKGPEDADT 541
+ V E+ E++ + + +G +RFPR R DK A
Sbjct: 451 DCNESMVPHLLAADPEKMPVWEIACSEMKANIGAHTAGVTMRFPRVKRFRPDKDWSTATD 510
Query: 542 IERIAQL 548
++ QL
Sbjct: 511 LQEAEQL 517
>emb|CAB92891.1| (AL356932) probable ATP-dependent DNA ligase. [Streptomyces
coelicolor A3(2)]
Length = 326
Score = 123 bits (305), Expect = 6e-27
Identities = 106/334 (31%), Positives = 163/334 (48%), Gaps = 36/334 (10%)
Query: 221 PIKPMLAQQAANIKEALLEMGGEAE--FEIKYDGARVQVHKDGE-KVTIYSRRLENVTRA 277
PI PMLA L G + +E K DG RV V+ G+ V + +R +++T A
Sbjct: 5 PIPPMLATPGT-----LPPAGQDTRWAYETKQDGQRVVVYLPGDGSVLLRARSGQDITAA 59
Query: 278 IPEIVEAIKEALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFRRKYN---IEEMMEKIPL 334
PE+ + AL T A+++GE++A+ E GR FQ + R + K+P+
Sbjct: 60 YPELAP-LATALGGTPAVLDGEVLALDEQGRA-DFQLLQSRMGLAHTPARAAHRAAKVPV 117
Query: 335 ELNLFDVLYVDGVSLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALE 394
L LFD L++ G SL+ + RR++L ++ L V Q + E
Sbjct: 118 HLVLFDALHLAGRSLLRLPYTGRRERLTDLGLNGPSWSTPAAL----VGHGAQALRATRE 173
Query: 395 MGHEGLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAY 454
G EGL+ KRLD+VYEPG R + W+KI+ M + D+V+ G G+GR L G+ ++G
Sbjct: 174 HGLEGLVCKRLDSVYEPGVRSRAWIKIR-NMRSEDVVVGGWLPGKGRLGGLPGAVLVG-- 230
Query: 455 DPETGEFLEVGKVGSGFTDDDLVEFTKMLKPL---------IIKEEGKRVWIQPKVVIEV 505
G VG VG+G++ + E +L + + G R W+ P++V EV
Sbjct: 231 QRAAGRLRYVGGVGTGWSAGERTELAALLAAAASDVCPFDPVPRVPGAR-WVVPRLVGEV 289
Query: 506 TYQEIQKSPKYRSGFALRFPRYVALREDKGPEDA 539
Y S + R G LR P ++ LR D PE++
Sbjct: 290 RY-----STRTREGM-LRQPSWLRLRPDLAPEES 317
>pir||C83378 probable ATP-dependent DNA ligase PA2138 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9948155|gb|AAG05526.1|AE004641_5 (AE004641) probable
ATP-dependent DNA ligase [Pseudomonas aeruginosa]
Length = 840
Score = 115 bits (284), Expect = 2e-24
Identities = 96/328 (29%), Positives = 158/328 (47%), Gaps = 38/328 (11%)
Query: 221 PIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPE 280
P+ +A + A++ E GE +E+K DG R+ + V + +R + T +P
Sbjct: 212 PMPEWIAPELASLVEQ--PPRGEWAYELKLDGYRLMSRIEDGHVRLLTRNGHDWTERLPH 269
Query: 281 IVEAIKEALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFR--RKYNIEEMMEKIPLELNL 338
+ +A+ L ++ ++GELV + E+GRP FQ + F R NI + L
Sbjct: 270 LEKALA-GLGLQRSWLDGELVVLDEEGRP-DFQALQNAFEEGRGENILYV---------L 318
Query: 339 FDVLYVDGVSLIDTKFMERRKKLEEIVETNGKVKIAENLITKNVEEAEQFYKRALEMGHE 398
FD+ Y +G L D ERR +LE ++E G+ + E+ A ++G E
Sbjct: 319 FDLPYHEGEDLRDVALEERRARLEALLE--GRDEDPLRFSATLAEDPRDLLASACKLGLE 376
Query: 399 GLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPET 458
G++ KRL + Y R W+K+K + + VI+G +G R H +G+ +LG Y P+
Sbjct: 377 GVIGKRLGSAYR-SRRSNDWIKLKCQLRQ-EFVIVGYTEPKGSRRH-IGALLLGLYSPDE 433
Query: 459 GEFLE-VGKVGSGFTDDDLVEFTKMLKPLII-----------KEEGKRVWIQPKVVIEVT 506
L GKVGSGFT L + + L+PL + +E G W++P+ + EV+
Sbjct: 434 ERRLRYAGKVGSGFTAASLKKVRERLEPLAVRSSPLAKVPPARETGSVQWVRPQQLCEVS 493
Query: 507 YQEIQKSPKYRSGFALRFPRYVALREDK 534
Y ++ + G +R + LREDK
Sbjct: 494 YAQMTR------GGIIRQAVFHGLREDK 515
>pir||T35025 probable DNA ligase - Streptomyces coelicolor
>gi|5139563|emb|CAB45581.1| (AL079355) putative DNA
ligase [Streptomyces coelicolor A3(2)]
Length = 355
Score = 111 bits (274), Expect = 3e-23
Identities = 99/350 (28%), Positives = 162/350 (46%), Gaps = 57/350 (16%)
Query: 221 PIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPE 280
P+KPMLA+ A I + +E K+DG R V++DG++V + SR + +TR PE
Sbjct: 8 PVKPMLAKSVAKIPPGM-------HYEAKWDGFRAIVYRDGDEVELGSRTGKPLTRYFPE 60
Query: 281 IVEAIKEALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFR-RKYNIEEMMEKIPLELNLF 339
+V A++E L P + +V+GE+V I DG L F + R + + E+ P L F
Sbjct: 61 LVVAVRERL-PERCVVDGEIV-IARDGH-LDFDALTERIHPADSRVRTLAERTPASLVAF 117
Query: 340 DVLYVDGVSLIDTKFMERRKKLEEIVE-TNGKVKIAENLITKNVEEAEQFYKRALEMGHE 398
D+L +D SL+D +RR L + V +A T ++E A +++++ G +
Sbjct: 118 DLLALDDASLLDVGLADRRALLVRALSGVTPPVHVAP--ATDDIEVARRWFEQYEGAGLD 175
Query: 399 GLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDPET 458
G++AK LD Y R +K + T D+V+ G + + ++GS +LG YD +
Sbjct: 176 GVVAKPLDLRYRQDERAMYKIKHERT---ADVVVAGYRF--HKSGPVVGSLLLGLYD-DR 229
Query: 459 GEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKRVW---------------------- 496
G VG V + FT E L+PL + + W
Sbjct: 230 GLLQHVG-VSAAFTMKRRAELVAELEPLRMDDARGHPWAAWAEEAAHESARLPGAPSRWS 288
Query: 497 ---------IQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGPE 537
++P+ V+EV Y ++ ++R RF R+ R D+ PE
Sbjct: 289 GKKDLSWVPLRPERVVEVAYDHMENGARFR--HTARFRRW---RPDRTPE 333
>sp|P71571|Y938_MYCTU HYPOTHETICAL 83.6 KDA PROTEIN RV0938 >gi|7476562|pir||B70585
hypothetical protein Rv0938 - Mycobacterium tuberculosis
(strain H37RV) >gi|3261755|emb|CAB08492.1| (Z95209)
hypothetical protein Rv0938 [Mycobacterium tuberculosis]
Length = 759
Score = 110 bits (272), Expect = 5e-23
Identities = 94/304 (30%), Positives = 146/304 (47%), Gaps = 37/304 (12%)
Query: 246 FEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPTKAIVEGELVAIGE 305
FE K+DG R+ V D V + SR +VT P++ A+ E L +++GE V +
Sbjct: 478 FEGKWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQL-RALAEDLADHHVVLDGEAVVLDS 536
Query: 306 DGRPLPFQYVLRRFRRKYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEIV 365
G P F + R R +E FD+LY+DG +L+ T++ +RRK LE +
Sbjct: 537 SGVP-SFSQMQNRGR----------DTRVEFWAFDLLYLDGRALLGTRYQDRRKLLETLA 585
Query: 366 ETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTM 425
+ + E L + Q + + + G EG++AKR D+ Y+PG R W+K K
Sbjct: 586 NATS-LTVPELL----PGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDK-HW 639
Query: 426 ENLDLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKP 485
++VI G GEG R+ +GS ++G P G G+VG+G ++ +L +ML P
Sbjct: 640 NTQEVVIGGWRAGEGGRSSGVGSLLMGI--PGPGGLQFAGRVGTGLSERELANLKEMLAP 697
Query: 486 LIIKEEGKRV-----------WIQPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDK 534
L E V +++P +V EV Y E +P+ R LR + LR DK
Sbjct: 698 LHTDESPFDVPLPARDAKGITYVKPALVAEVRYSE--WTPEGR----LRQSSWRGLRPDK 751
Query: 535 GPED 538
P +
Sbjct: 752 KPSE 755
>pir||T38940 dna ligase - fission yeast (Schizosaccharomyces pombe) (fragment)
>gi|2058380|emb|CAB08176.1| (Z94864) DNA ligase
[Schizosaccharomyces pombe]
Length = 474
Score = 108 bits (268), Expect = 1e-22
Identities = 89/329 (27%), Positives = 157/329 (47%), Gaps = 28/329 (8%)
Query: 3 YIELAQLYQKLEKTTMKLIKTRLVADFLKKVPEDH---LEFIPYLILGDVFPEWDERELG 59
+ E+ + + K+E T+ +L ++ + + DH L YL + + P++ ELG
Sbjct: 149 FAEMVKAFTKIENTSKRLEIIDIMGTYFFGILRDHPSDLLACVYLSINKLGPDYSGLELG 208
Query: 60 VGEKLLIKAVSMATGIDSKEIENSVKDTGDLGESIALAVKKRKQKSFFSQPLTIKRVYQT 119
+GE +++KA+ +TG ++I+ S GDLG +A ++ + F LTI ++ +
Sbjct: 209 IGESIIMKAIGESTGQTLQQIKLSFHKVGDLG-LVAQTSRQNQPTMFKPAALTIPFLFDS 267
Query: 120 LVKVAETTGEGSQDKKMKYLANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAIS--- 176
L K+A+ +G SQ++K+ + L E E KY+ R + G +R +AE + A++
Sbjct: 268 LKKIAQMSGNQSQNRKIGVIKRLLSSCEGAEPKYLIRALEGKLRLQLAEKTILVALANAT 327
Query: 177 -----------LAFNVKVE---LVERAYMLTSDFGFVAKIAKTEGNDGLAKV-TIQIGKP 221
L+ ++E ++ Y + + G L + + G P
Sbjct: 328 AQYHADKNGEKLSQQDRIEGEQILRDVYCQLPSYDLIVPHLIEHGLGTLRETCKLTPGIP 387
Query: 222 IKPMLAQQAANIKEALLEMGGEAEF--EIKYDGARVQVH--KDGEKVTIYSRRLENVTRA 277
KPMLA+ I E +L +A F E KYDG R QVH +DG K ++SR EN++
Sbjct: 388 TKPMLAKPTKQISE-VLNTFDQAAFTCEYKYDGERAQVHFTEDG-KFYVFSRNSENMSVR 445
Query: 278 IPEIVEAIKEALKPTKAIVEGELVAIGED 306
P+I ++ + KP + A+G D
Sbjct: 446 YPDISVSVSKWKKPDARSFILDCEAVGWD 474
>pir||S31138 hypothetical protein 3 (SFA 5' region) - yeast (Saccharomyces
cerevisiae) (fragment)
Length = 277
Score = 100 bits (246), Expect = 5e-20
Identities = 55/145 (37%), Positives = 80/145 (54%), Gaps = 17/145 (11%)
Query: 429 DLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII 488
DL ++GA +G G+R G F+LG Y+ +TGEF K+G+GF+D+ L L P II
Sbjct: 132 DLCVLGAYYGRGKRTGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQLLHDRLTPTII 191
Query: 489 ----------KEEGKRVWIQPKVVIEVTYQEIQKSPKYRSGFA-------LRFPRYVALR 531
VW +P + EV ++ SP Y++G A LRFPR++ +R
Sbjct: 192 DGPKATFVFDSSAEPDVWFEPTTLFEVLTADLSLSPIYKAGSATFDKGVSLRFPRFLRIR 251
Query: 532 EDKGPEDADTIERIAQLYELQERMK 556
EDKG EDA + ++I +LYE Q M+
Sbjct: 252 EDKGVEDATSSDQIVELYENQSHMQ 276
>pir||S74315 CDC9 protein - Saccharomyces cerevisiae >gi|600039|emb|CAA48158.1|
(X68020) CDC9 [Saccharomyces cerevisiae]
Length = 146
Score = 99.1 bits (243), Expect = 1e-19
Identities = 55/145 (37%), Positives = 80/145 (54%), Gaps = 17/145 (11%)
Query: 429 DLVIIGAEWGEGRRAHLLGSFILGAYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLII 488
DL ++GA +G G+R G F+LG Y+ +TGEF K+G+GF+D+ L L P II
Sbjct: 1 DLCVLGAYYGRGKRTGTYGGFLLGCYNQDTGEFETCCKIGTGFSDEMLQLLHDRLTPTII 60
Query: 489 KEEGKR----------VWIQPKVVIEVTYQEIQKSPKYRSGFA-------LRFPRYVALR 531
E VW +P + EV ++ SP Y++G A LRFP ++ +R
Sbjct: 61 DEPKATFVFDSSAEPDVWFEPTTLFEVLTADLSLSPIYKAGSATFDKGVSLRFPIFLRIR 120
Query: 532 EDKGPEDADTIERIAQLYELQERMK 556
EDKG EDA + ++I +LYE Q M+
Sbjct: 121 EDKGVEDATSSDQIVELYENQSHMQ 145
>gb|AAF48298.1| (AE003493) CG12176 gene product [Drosophila melanogaster]
Length = 918
Score = 97.1 bits (238), Expect = 4e-19
Identities = 126/522 (24%), Positives = 223/522 (42%), Gaps = 80/522 (15%)
Query: 82 NSVKDTGDLGESIALAVKKRKQKSFFSQP--LTIKRVYQTLVKVAETTGEGSQDKKMKYL 139
N +D GD+ S+ +K R F+ P L +K ++Q L +A E Q + +++
Sbjct: 117 NMYRDYGDVVYSV---LKPR----CFNPPSNLRLKEIHQMLDTIANEDTEVKQQQLIRFT 169
Query: 140 ANLFMDAEPIEAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFV 199
A P E K++ R +L ++ G+ E + F V + Y SD G V
Sbjct: 170 EQ----ASPEEQKWLIRLLLKSLGLGIGEQKI-------FGVLHPKAQDIYQRCSDLGHV 218
Query: 200 AKIAK--------TEGNDGLAKV-------TIQIGKPIKPMLAQQAANIKEALLEMGGEA 244
+ + D A V I+ I+PML ++ + L++
Sbjct: 219 CNLLADRTTDLDASSSKDSKAAVKFVNLNSVIRPFHQIRPMLCERFPGDIQELMQ-SDVL 277
Query: 245 EFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVEAIKEALKPT-KAIVEGELVAI 303
E K DG R Q+H D + SR + TR + L P + ++ L +I
Sbjct: 278 YLETKMDGERFQLHIDRGRFMYISRNGVDYTRNFGHSYD--HGTLTPKLRGLLPLGLESI 335
Query: 304 GEDGRPLPFQYVLRRFRRKYNIEEMMEKIPLE-----LNLFDVLYVDGVSLIDTKFMERR 358
DG + + RFR K ++ P ++D+LY +G SL+D +++R
Sbjct: 336 ILDGEMMVWDTNKLRFREKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRA 395
Query: 359 KKLEE-IVETNGKVKIAENLITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNR-GK 416
KL++ IVE +G +++ +V+E + +++AL+ EG++ K+ + Y+PG R G
Sbjct: 396 YKLQKLIVEQSGVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLKKQGSRYQPGVRLGG 455
Query: 417 KWLK-----IKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDP------ETGEFLEVG 465
W K IK + D++IIGA + R+ + SF+LG P E +G
Sbjct: 456 GWYKDKADYIKGLITEFDVLIIGAFY--NRKRTFVDSFLLGVLQPAPPGSSNRPEVFSIG 513
Query: 466 KVGSGFTDDDLVEFTKMLKPL---IIKEEG--------------KRVWIQPK--VVIEVT 506
V + ++ T LKP ++ E +WI+P+ V+++V
Sbjct: 514 VVANNTKQRGVLNHT--LKPHWHDVVNEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVK 571
Query: 507 YQEIQKSPKYRSGFALRFPRYVALREDKGPEDADTIERIAQL 548
++ + + + +L FPR R+DK + T++ L
Sbjct: 572 AADLAPNGAFFTRKSLHFPRTEMKRDDKTWSECMTLKEFNDL 613
>pir||D70797 probable DNA ligas - Mycobacterium tuberculosis (strain H37RV)
>gi|2960155|emb|CAA18053.1| (AL022121) ligC
[Mycobacterium tuberculosis]
Length = 358
Score = 83.5 bits (203), Expect = 6e-15
Identities = 69/253 (27%), Positives = 120/253 (47%), Gaps = 19/253 (7%)
Query: 221 PIKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPE 280
P+ PMLA+ I +A +E K+DG R +DG++V + SR +TR PE
Sbjct: 8 PVSPMLAKSVTAIPP-------DASYEPKWDGFRSICFRDGDQVELGSRNERPMTRYFPE 60
Query: 281 IVEAIKEALKPTKAIVEGELVAIGEDGRPLPFQYVLRRFR-RKYNIEEMMEKIPLELNLF 339
+V AI+ L P + +++GE++ + G L F+ + +R + + + ++ P F
Sbjct: 61 LVAAIRAEL-PHRCVIDGEIIIATDHG--LDFEALQQRIHPAESRVRMLADRTPASFIAF 117
Query: 340 DVLYVDGVSLIDTKFMERRKKLEEIVETNG---KVKIAENLITKNVEEAEQFYKRALEMG 396
D+L + F ERR L + V +G + I T ++ A++++ G
Sbjct: 118 DLLALGDDDYTGRPFSERRAALVDAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAG 177
Query: 397 HEGLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFILGAYDP 456
+G++AK Y+P R KIK + D V+ G + + +GS +LG Y
Sbjct: 178 LDGVIAKPPHITYQPDKR--VMFKIK-HLRTADCVVAGYRVHKS-GSDAIGSLLLGLYQ- 232
Query: 457 ETGEFLEVGKVGS 469
E G+ VG +G+
Sbjct: 233 EDGQLASVGVIGA 245
>gi|6324578 ATP dependent DNA ligase; Dnl4p [Saccharomyces cerevisiae]
>gi|2494163|sp|Q08387|DNL4_YEAST DNA LIGASE II
(POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP]) (DNA LIGASE IV
HOMOLOG) >gi|2131241|pir||S66870 DNL4 protein - yeast
(Saccharomyces cerevisiae) >gi|1420096|emb|CAA99193.1|
(Z74913) ORF YOR005c [Saccharomyces cerevisiae]
Length = 944
Score = 82.7 bits (201), Expect = 1e-14
Identities = 107/455 (23%), Positives = 199/455 (43%), Gaps = 43/455 (9%)
Query: 42 PYLILGDVFPEWDERELGVGEKLLIKAV--------SMATGIDSKEIENSVKDTGDLGES 93
P L+L P D R + + +LI+ + + AT K+ + V G+L
Sbjct: 71 PALVLA--LPYRDRRIYNIKDYVLIRTICSYLKLPKNSATEQRLKDWKQRVGKGGNLSSL 128
Query: 94 IALAVKKRKQKSFFSQPLTIKRVYQTLVKVAE---TTGEGSQDK-KMKYLANLFMDAEPI 149
+ + KR+ + S+ +TI V L ++ +G G + K K + + +
Sbjct: 129 LVEEIAKRRAEPS-SKAITIDNVNHYLDSLSGDRFASGRGFKSLVKSKPFLHCVENMSFV 187
Query: 150 EAKYIARTVLGTMRTGVAEGLLRDAISLAFNVKVELVERAYMLTSDFGFVAKIAKTEGND 209
E KY VL G E L + + ++ ++TS + K+ + +
Sbjct: 188 ELKYFFDIVLKNRVIGGQEHKLLNCWHPDAQDYLSVISDLKVVTSKL-YDPKVRLKDDD- 245
Query: 210 GLAKVTIQIGKPIKPMLAQQAANIKEALLE-MGGEAEFEIKYDGARVQVH--KDGEKVTI 266
++I++G P LA++ E + + + E K DG R+QVH GE +
Sbjct: 246 ----LSIKVGFAFAPQLAKKVNLSYEKICRTLHDDFLVEEKMDGERIQVHYMNYGESIKF 301
Query: 267 YSRR------LENVTRAIPEIVEAIKEALKPTKAIVEGELVAIGEDGRP-LPFQYVLRRF 319
+SRR L + + I + ++ + +++GE+V R LPF V
Sbjct: 302 FSRRGIDYTYLYGASLSSGTISQHLRFTDSVKECVLDGEMVTFDAKRRVILPFGLVKGSA 361
Query: 320 RR--KYNIEEMMEKIPLELNLFDVLYVDGVSLIDTKFMERRKKLEEIVET-NGKVKIAEN 376
+ +N ++ PL + +FD+LY++G SL +R++ L I+ V+I +
Sbjct: 362 KEALSFNSINNVDFHPLYM-VFDLLYLNGTSLTPLPLHQRKQYLNSILSPLKNIVEIVRS 420
Query: 377 LITKNVEEAEQFYKRALEMGHEGLMAKRLDAVYEPGNRGKKWLKIKPTM-----ENLDLV 431
VE ++ + A+ +G EG++ K ++ Y +R W+K+KP ENLDL+
Sbjct: 421 SRCYGVESIKKSLEVAISLGSEGVVLKYYNSSYNVASRNNNWIKVKPEYLEEFGENLDLI 480
Query: 432 IIGAEWGEGRRAHLLGSFILG--AYDPETGEFLEV 464
+IG + G+ + + +LG +L Y G+ E+
Sbjct: 481 VIGRDSGK-KDSFMLGLLVLDEEEYKKHQGDSSEI 514
>dbj|BAB05928.1| (AP001514) unknown conserved protein [Bacillus halodurans]
Length = 611
Score = 79.6 bits (193), Expect = 8e-14
Identities = 91/336 (27%), Positives = 140/336 (41%), Gaps = 54/336 (16%)
Query: 222 IKPMLAQQAANIKEALLEMGGEAEFEIKYDGARVQVHKDGEKVTIYSRRLENVTRAIPEI 281
+KPML Q + L G +E+KYDG R + E + + SR +T PEI
Sbjct: 1 MKPMLLQTTTD-----LPTGDNWRYEVKYDGFRTILFWTKETIRLESRNERLLTDQFPEI 55
Query: 282 VEAIKEALKPTKA----IVEGELVAIGEDGRPLPFQYVLRRFRRKYN-IEEMMEKIPLEL 336
+ + +A ++GELV + R R F RK+ I K P L
Sbjct: 56 HDFCQRISNKVEAWLPITIDGELVHLVSPYRAHFAPIQTRSFMRKHETIAASSIKTPATL 115
Query: 337 NLFDVLYVDGVSLIDTKFMERRKKLEEI---VETNGKVKIAENLITKNV--EEAEQFYKR 391
FD+L + G +L+D + ER+K+L+ + ++ + I N + + + Q +
Sbjct: 116 LAFDILELKGKTLVDLPYDERKKQLKALLKAIDVPLEPTIQSNACLQMIPAQTDGQALWQ 175
Query: 392 ALEMGH-EGLMAKRLDAVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFI 450
A+E+ H EG++AK + + G R +WLK K N V +
Sbjct: 176 AVELHHGEGVVAKDRFSDWTEGKRTNRWLKKK----NFRQVTV----------------F 215
Query: 451 LGAYDPETGEF----------LEVGKVGSGFTDDDLVEFTKMLKPLIIKEEGKRVWIQPK 500
L AYDP G F +EVG V GF D + +K +K +GKR ++P
Sbjct: 216 LTAYDPVNGYFHFAVYRDGTSVEVGNVTHGFEDHERETLIAFMKQNGMK-KGKRYVLEPS 274
Query: 501 VVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKGP 536
V +V + G LR P + R D P
Sbjct: 275 VCFDVDCIDF-------DGKHLREPMFHRFRLDVKP 303
>pir||S71741 DNA ligase (ATP) (EC 6.5.1.1) - yeast (Candida albicans)
Length = 864
Score = 74.9 bits (181), Expect = 2e-12
Identities = 87/356 (24%), Positives = 158/356 (43%), Gaps = 56/356 (15%)
Query: 239 EMGGEAEFEI--KYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVE--AIKEALKPTKA 294
E+G E +F I K DG R+ +HKDG+ +SRRL++ + E + A+ + L A
Sbjct: 292 ELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAFA 351
Query: 295 ------IVEGELVAIG-EDGRPLPF----QYVLRRFRRKYNIEEMMEK---IPLELNLFD 340
I++GE+VA E LPF ++ R++ + E+ P L +FD
Sbjct: 352 GNIQSVILDGEMVAYDYERNVILPFGTLKSLAIQESVRQFTTIDQYEQQTAYPFFL-VFD 410
Query: 341 VLYVDGVSLIDTKFMERRKKLEEIVE-TNGKVKIAENLITKNVEEAEQFYKRALEMGHEG 399
+L+++G L + R+ L I+ + ++ + + ++E+ E+ + + EG
Sbjct: 411 ILFLNGKDLTNYPLFFRKNILNRILRPIPNRFEVLDTRLGSSLEDIERAIREVVSSRCEG 470
Query: 400 LMAKRLDAVYE-PGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRRAHLLGSFILGA 453
L+ K + YE G R W+K+KP ENLDLV+I G+ + S++ G
Sbjct: 471 LVLKNVQLKYEIDGFRNPDWIKVKPEYLEKFGENLDLVVI------GKSPAIKNSYMCGL 524
Query: 454 YDPETGEFLEVGKVGSGFTDDDLVEFTKM--------------LKPLIIKEEGKRV---W 496
G + +G ++ EF K+ + P ++ + G ++ W
Sbjct: 525 KSVTDGFIIVFCTCANGI---EIEEFDKIERLTHGKWIKTDVSMPPELLIKFGTKIPTFW 581
Query: 497 IQP--KVVIEVTYQEI--QKSPKYRSGFALRFPRYVALREDKGPEDADTIERIAQL 548
I P +V+E+ + I + Y G L +REDK ++ T++ +
Sbjct: 582 IHPSDSLVLEIRARSIDTRAGTLYAVGSTLHNNHCRKIREDKSIDECVTLQEYTHI 637
>sp|P52496|DNLI_CANAL DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
Length = 864
Score = 73.7 bits (178), Expect = 5e-12
Identities = 87/354 (24%), Positives = 154/354 (42%), Gaps = 52/354 (14%)
Query: 239 EMGGEAEFEI--KYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVE--AIKEALKPTKA 294
E+G E +F I K DG R+ +HKDG+ +SRRL++ + E + A+ + L A
Sbjct: 292 ELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAFA 351
Query: 295 ------IVEGELVAIG-EDGRPLPF--------QYVLRRFRRKYNIEEMMEKIPLELNLF 339
I++GE+VA E LPF Q +R+F + E P L +F
Sbjct: 352 GNIQSVILDGEMVAYDYERNVILPFGTLKSSAIQESVRQF-TTIDQYEQQTAYPFFL-VF 409
Query: 340 DVLYVDGVSLIDTKFMERRKKLEEIVE-TNGKVKIAENLITKNVEEAEQFYKRALEMGHE 398
D+L+++G L + R+ L I+ + ++ + + + E+ E+ + + E
Sbjct: 410 DILFLNGKDLTNYPLFFRKNILNRILRPIPNRFEVLDTRLGSSSEDIERAIREVVSSRCE 469
Query: 399 GLMAKRLDAVYE-PGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRRAHLLGSFILG 452
GL+ K + + YE G R W+K+KP ENLDLV+I G+ + S++ G
Sbjct: 470 GLVLKNVQSKYEIDGFRNPDWIKVKPEYLEKFGENLDLVVI------GKSPAIKNSYMCG 523
Query: 453 AYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEE-----------GKRV---WIQ 498
G + +G ++ + ++ IK + G ++ WI
Sbjct: 524 LKSVTDGFIIVFCTCANGIEIEEFDKIERLTHGKWIKTDVSMPPESLIKFGTKIPTFWIH 583
Query: 499 P--KVVIEVTYQEI--QKSPKYRSGFALRFPRYVALREDKGPEDADTIERIAQL 548
P +V+E+ + I + Y G L +REDK ++ T++ +
Sbjct: 584 PSDSLVLEIRARSIDTRAGTSYAVGSTLHNNHCRKIREDKSIDECVTLQEYTHI 637
>emb|CAA64457.2| (X95001) ATP-dependent DNA ligase [Candida albicans]
Length = 928
Score = 73.7 bits (178), Expect = 5e-12
Identities = 87/354 (24%), Positives = 154/354 (42%), Gaps = 52/354 (14%)
Query: 239 EMGGEAEFEI--KYDGARVQVHKDGEKVTIYSRRLENVTRAIPEIVE--AIKEALKPTKA 294
E+G E +F I K DG R+ +HKDG+ +SRRL++ + E + A+ + L A
Sbjct: 292 ELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAFA 351
Query: 295 ------IVEGELVAIG-EDGRPLPF--------QYVLRRFRRKYNIEEMMEKIPLELNLF 339
I++GE+VA E LPF Q +R+F + E P L +F
Sbjct: 352 GNIQSVILDGEMVAYDYERNVILPFGTLKSSAIQESVRQF-TTIDQYEQQTAYPFFL-VF 409
Query: 340 DVLYVDGVSLIDTKFMERRKKLEEIVE-TNGKVKIAENLITKNVEEAEQFYKRALEMGHE 398
D+L+++G L + R+ L I+ + ++ + + + E+ E+ + + E
Sbjct: 410 DILFLNGKDLTNYPLFFRKNILNRILRPIPNRFEVLDTRLGSSSEDIERAIREVVSSRCE 469
Query: 399 GLMAKRLDAVYE-PGNRGKKWLKIKPTM-----ENLDLVIIGAEWGEGRRAHLLGSFILG 452
GL+ K + + YE G R W+K+KP ENLDLV+I G+ + S++ G
Sbjct: 470 GLVLKNVQSKYEIDGFRNPDWIKVKPEYLEKFGENLDLVVI------GKSPAIKNSYMCG 523
Query: 453 AYDPETGEFLEVGKVGSGFTDDDLVEFTKMLKPLIIKEE-----------GKRV---WIQ 498
G + +G ++ + ++ IK + G ++ WI
Sbjct: 524 LKSVTDGFIIVFCTCANGIEIEEFDKIERLTHGKWIKTDVSMPPESLIKFGTKIPTFWIH 583
Query: 499 P--KVVIEVTYQEI--QKSPKYRSGFALRFPRYVALREDKGPEDADTIERIAQL 548
P +V+E+ + I + Y G L +REDK ++ T++ +
Sbjct: 584 PSDSLVLEIRARSIDTRAGTSYAVGSTLHNNHCRKIREDKSIDECVTLQEYTHI 637
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.317 0.138 0.380
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 195596019
Number of Sequences: 2977
Number of extensions: 8379252
Number of successful extensions: 25020
Number of sequences better than 1.0e-10: 74
Number of HSP's better than 0.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 24596
Number of HSP's gapped (non-prelim): 87
length of query: 559
length of database: 189,106,746
effective HSP length: 60
effective length of query: 499
effective length of database: 153,197,526
effective search space: 76445565474
effective search space used: 76445565474
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 167 (69.5 bits)