BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2018 (glyA) DE:serine hydroxymethyltransferase (glyA)
(427 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||F75169 serine hydroxymethyltransferase (glya) PAB2018 - Pyr... 883 0.0
sp|O59347|GLYA_PYRHO SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 874 0.0
sp|Q58992|GLYA_METJA SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 469 e-131
sp|O27433|GLYA_METTH SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 444 e-124
emb|CAB57769.1| (Y18930) serine hydroxymethyltransferase [Sulfol... 441 e-123
gb|AAK40850.1| Serine hydroxymethyltransferase (glyA) [Sulfolobu... 441 e-123
sp|Q9YAH7|GLYA_AERPE SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 440 e-122
sp|P50436|GLYA_METTM SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 432 e-120
gi|11498458 serine hydroxymethyltransferase (glyA) [Archaeoglobu... 421 e-117
emb|CAC12627.1| (AL445067) probable glycine hydroxymethyltransfe... 404 e-111
sp|O66776|GLYA_AQUAE SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 259 3e-68
sp|P06192|GLYA_SALTY SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 243 3e-63
gb|AAG19732.1| (AE005059) glycine hydroxymethyltransferase; GlyA... 242 6e-63
sp|P00477|GLYA_ECOLI SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 241 1e-62
sp|Q9WZH9|GLYA_THEMA SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 240 2e-62
sp|P57376|GLYA_BUCAI SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 240 3e-62
sp|P34894|GLYA_ACTAC SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 239 4e-62
pdb|1EQB|B Chain B, X-Ray Crystal Structure At 2.7 Angstroms Res... 239 4e-62
sp|P34895|GLYA_HYPME SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 239 5e-62
sp|P39148|GLYA_BACSU SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 238 7e-62
sp|P77962|GLYA_SYNY3 SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 237 2e-61
sp|O08370|GLYA_RICPR SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 235 8e-61
pir||H82258 serine hydroxymethyltransferase VC0941 [imported] - ... 235 8e-61
pir||C83341 serine hydroxymethyltransferase PA2444 [imported] - ... 234 1e-60
pir||G82968 serine hydroxymethyltransferase PA5415 [imported] - ... 234 2e-60
pir||F75567 serine hydroxymethyltransferase - Deinococcus radiod... 233 2e-60
sp|P24060|GLYA_BRAJA SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 233 3e-60
pir||S30382 glycine hydroxymethyltransferase (EC 2.1.2.1) [simil... 233 4e-60
sp|O85718|GLYA_ACIRA SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 232 7e-60
sp|O51547|GLYA_BORBU SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 231 9e-60
sp|Q9XAZ1|GLYA_NEIMC SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 231 1e-59
sp|Q9XAY7|GLYA_NEIMA SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 231 2e-59
dbj|BAB07484.1| (AP001519) serine hydroxymethyltransferase [Baci... 230 3e-59
sp|P56990|GLYA_NEIMB SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 229 5e-59
sp|Q9XB01|GLYA_NEIGO SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 227 2e-58
emb|CAB44942.1| (AJ242840) putative serine hydroxymethyltransfer... 227 2e-58
pir||E82743 serine hydroxymethyltransferase XF0946 [imported] - ... 222 6e-57
pir||A82480 serine hydroxymethyltransferase VCA0278 [imported] -... 222 8e-57
sp|P43844|GLYA_HAEIN SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 220 2e-56
pir||D83070 serine hydroxymethyltransferase PA4602 [imported] - ... 220 3e-56
pir||JQ1016 glycine hydroxymethyltransferase (EC 2.1.2.1) - Camp... 219 4e-56
sp|P50435|GLYA_METEX SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 219 5e-56
sp|P24531|GLYA_CAMJE SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 219 7e-56
sp|P56089|GLYA_HELPY SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 213 2e-54
sp|P78011|GLYA_MYCPN SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 210 3e-53
sp|Q9ZMP7|GLYA_HELPJ SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 208 1e-52
emb|CAC11940.1| (AL445065) glycine hydroxymethyltransferase rela... 208 1e-52
emb|CAB94535.1| (AL359152) serine hydroxymethyltransferase [Stre... 207 2e-52
sp|O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 203 3e-51
pir||T05362 glycine hydroxymethyltransferase (EC 2.1.2.1) F8B4.2... 203 3e-51
sp|P47634|GLYA_MYCGE SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 202 6e-51
gb|AAF46101.1| (AE003435) CG3011 gene product [Drosophila melano... 199 5e-50
gi|4759106 serine hydroxymethyltransferase 1 (soluble); cytoplas... 191 1e-47
sp|P50433|GLYM_SOLTU SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDR... 191 1e-47
pdb|1BJ4|A Chain A, Recombinant Serine Hydroxymethyltransferase ... 190 2e-47
pir||B71400 glycine hydroxymethyltransferase (EC 2.1.2.1) - Arab... 189 7e-47
emb|CAB94023.1| (AL358652) (mitochondrial?) serine hydroxymethyl... 189 7e-47
sp|P35623|GLYC_SHEEP SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC ... 187 2e-46
gb|AAF86546.1|AC069252_5 (AC069252) F2E2.7 [Arabidopsis thaliana] 187 3e-46
sp|P07511|GLYC_RABIT SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC ... 186 4e-46
sp|O53615|GLA2_MYCTU SERINE HYDROXYMETHYLTRANSFERASE 2 (SERINE M... 186 4e-46
pdb|1CJ0|A Chain A, Crystal Structure Of Rabbit Cytosolic Serine... 186 4e-46
pir||T05258 glycine hydroxymethyltransferase (EC 2.1.2.1) F18A5.... 186 5e-46
pir||S40497 serine hydroxymethyltransferase - sheep >gi|545298|g... 185 6e-46
pir||S72452 glycine hydroxymethyltransferase (EC 2.1.2.1) - sheep 185 6e-46
sp|P34899|GLYM_PEA SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIA... 185 1e-45
sp|P49357|GLYM_FLAPR SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDR... 184 1e-45
sp|Q9X794|GLYA_MYCLE SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 183 2e-45
sp|O13426|GLYC_CANAL SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC ... 183 4e-45
pir||T05620 glycine hydroxymethyltransferase (EC 2.1.2.1) F20D10... 182 7e-45
sp|Q10104|GLY1_SCHPO PROBABLE SERINE HYDROXYMETHYLTRANSFERASE, C... 182 9e-45
sp|P50432|GLYC_CAEEL SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 181 1e-44
sp|P49358|GLYN_FLAPR SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDR... 181 2e-44
gb|AAF34299.1| (AC021199) putative hydroxymethyltransferase; 495... 181 2e-44
sp|O53441|GLA1_MYCTU SERINE HYDROXYMETHYLTRANSFERASE 1 (SERINE M... 180 3e-44
emb|CAB72302.2| (AL138973) serine hydroxymethyltransferase [Leis... 179 5e-44
pdb|1EJI|A Chain A, Recombinant Serine Hydroxymethyltransferase ... 179 6e-44
sp|O13972|GLY2_SCHPO PROBABLE SERINE HYDROXYMETHYLTRANSFERASE, C... 178 1e-43
gb|AAA21023.1| (L22529) serine hydroxymethyltransferase [Sacchar... 174 2e-42
gb|AAA36018.1| (L23928) serine hydroxymethyltransferase [Homo sa... 173 3e-42
sp|O13425|GLYM_CANAL SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDR... 173 4e-42
gi|6323087 serine hydroxymethyltransferase; Shm2p [Saccharomyces... 173 5e-42
sp|P34898|GLYC_NEUCR SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC ... 172 6e-42
gi|6319739 Serine hydroxymethyltransferase, mitochondrial; Shm1p... 170 2e-41
pir||B46746 glycine hydroxymethyltransferase (EC 2.1.2.1) precur... 170 2e-41
gi|4885595 serine hydroxymethyltransferase 2 (mitochondrial) [Ho... 170 2e-41
sp|P34897|GLYM_HUMAN SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDR... 170 2e-41
sp|O83349|GLYA_TREPA SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 170 3e-41
gb|AAF07198.1|AF195023_1 (AF195023) SHMT [Plasmodium falciparum] 169 4e-41
pir||A33696 glycine hydroxymethyltransferase (EC 2.1.2.1), mitoc... 169 5e-41
sp|P37292|GLYM_YEAST SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDR... 169 5e-41
emb|CAB89056.1| (AL353872) serine hydroxymethyltransferase [Stre... 169 7e-41
sp|P14519|GLYM_RABIT SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDR... 167 3e-40
gb|AAD33721.1| (AF136495) GlyA [Campylobacter lari] 164 2e-39
pir||H72067 glycine hydroxymethyltransferase (EC 2.1.2.1) - Chla... 162 7e-39
sp|Q9Z831|GLYA_CHLPN SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 162 7e-39
pir||C81672 serine hydroxymethyltransferase TC0716 [imported] - ... 159 6e-38
pir||T01759 glycine hydroxymethyltransferase (EC 2.1.2.1) A_IG00... 157 3e-37
sp|O84439|GLYA_CHLTR SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 155 7e-37
sp|O62585|GLYC_ENCCU SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC ... 155 9e-37
gb|AAD33719.1| (AF136493) GlyA [Campylobacter jejuni] 155 9e-37
gb|AAD33720.1| (AF136494) GlyA [Campylobacter coli] 155 9e-37
gb|AAD33722.1| (AF136496) GlyA [Campylobacter upsaliensis] 147 2e-34
emb|CAB54840.1| (Y14487) cytosolic serine hydroxymethyltransfera... 146 4e-34
emb|CAB54839.1| (Y14486) cytosolic serine hydroxymethyltransfera... 132 7e-30
sp|P50431|GLYC_MOUSE SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC ... 123 4e-27
gb|AAA36019.1| (L23928) serine hydroxymethyltransferase [Homo sa... 122 8e-27
gi|6677943 serine hydroxymethyl transferase 1 (soluble) [Mus mus... 117 2e-25
sp|P50434|GLYA_CORS1 SERINE HYDROXYMETHYLTRANSFERASE (SERINE MET... 101 2e-20
gb|AAF68430.1|AF239165_1 (AF239165) serine hydroxymethyltransfer... 75 2e-12
>pir||F75169 serine hydroxymethyltransferase (glya) PAB2018 - Pyrococcus abyssi
(strain Orsay) >gi|5457947|emb|CAB49437.1| (AJ248284)
serine hydroxymethyltransferase (glyA) [Pyrococcus
abyssi]
Length = 427
Score = 883 bits (2258), Expect = 0.0
Identities = 427/427 (100%), Positives = 427/427 (100%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY
Sbjct: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG
Sbjct: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
Query: 121 HISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK 180
HISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK
Sbjct: 121 HISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK 180
Query: 181 ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK 240
ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK
Sbjct: 181 ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK 240
Query: 241 FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALA 300
FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALA
Sbjct: 241 FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALA 300
Query: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE 360
EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE
Sbjct: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE 360
Query: 361 PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFD
Sbjct: 361 PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
Query: 421 YGLPMKE 427
YGLPMKE
Sbjct: 421 YGLPMKE 427
>sp|O59347|GLYA_PYRHO SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433544|pir||F71045 probable serine
hydroxymethyltransferase - Pyrococcus horikoshii
>gi|3258083|dbj|BAA30766.1| (AP000006) 427aa long
hypothetical serine hydroxymethyltransferase [Pyrococcus
horikoshii]
Length = 427
Score = 874 bits (2233), Expect = 0.0
Identities = 420/427 (98%), Positives = 425/427 (99%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M Y+EYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWP+QRYY
Sbjct: 1 MTYREYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPKQRYY 60
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
QGCKYVDEVELIGVELFTKLFKSDYADLRP+SGTNANQAVFFGLGQPGDKVIVLHTSHGG
Sbjct: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPVSGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
Query: 121 HISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK 180
HISHMPFGAAGMRGLEVHTWPFD ESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK
Sbjct: 121 HISHMPFGAAGMRGLEVHTWPFDFESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK 180
Query: 181 ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK 240
ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK
Sbjct: 181 ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK 240
Query: 241 FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALA 300
FADDETIAKLQWAIFPGV+SNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALA
Sbjct: 241 FADDETIAKLQWAIFPGVVSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALA 300
Query: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE 360
EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE
Sbjct: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE 360
Query: 361 PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL+DKEDPKKVRKDVYYFRLEYQKVYYSFD
Sbjct: 361 PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLIDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
Query: 421 YGLPMKE 427
YGLPMKE
Sbjct: 421 YGLPMKE 427
>sp|Q58992|GLYA_METJA SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|2127941|pir||D64499 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Methanococcus jannaschii
>gi|1592207|gb|AAB99615.1| (U67599) serine
hydroxymethyltransferase (glyA) [Methanococcus
jannaschii]
Length = 429
Score = 469 bits (1195), Expect = e-131
Identities = 236/411 (57%), Positives = 294/411 (71%), Gaps = 7/411 (1%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
I++HE W +I LIASENITS +V A A+ FMH+YAEG P +R YQGCKY+DEVE +
Sbjct: 15 IKQHE-WMRESIKLIASENITSLAVREACATDFMHRYAEGLPGKRLYQGCKYIDEVETLC 73
Query: 74 VELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMR 133
+EL +LFK+++A+++P SG AN AVFF +PGDK++ L GGHISH AAG+R
Sbjct: 74 IELSKELFKAEHANVQPTSGVVANLAVFFAETKPGDKLMALSVPDGGHISHWKVSAAGIR 133
Query: 134 GLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFV 193
GL+V PFD E NID D K I E +PK+++FGGSLFPFPHPV + A+EVGA +
Sbjct: 134 GLKVINHPFDPEEMNIDADAMVKKILEEKPKLILFGGSLFPFPHPVADAYEAAQEVGAKI 193
Query: 194 VYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWA 253
YD AHVLGLIAG +FQDPLREGA+ + STHKTF GPQGGVIL K E K+
Sbjct: 194 AYDGAHVLGLIAGKQFQDPLREGAEYLMGSTHKTFFGPQGGVILTTK----ENADKIDSH 249
Query: 254 IFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGY 313
+FPGV+SNHHLHH AG I AEMLE+GEAYAKQ++KNAKALA+AL E GF V+ E + +
Sbjct: 250 VFPGVVSNHHLHHKAGLAIALAEMLEFGEAYAKQVIKNAKALAQALYERGFNVLCEHKDF 309
Query: 314 TKSHQVIVDVSDLHPA--GGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEM 371
T+SHQVI+D+ A + EEA IILNKNLLPWD + + PSG+R+G QE
Sbjct: 310 TESHQVIIDIESSPDIEFSASELAKMYEEANIILNKNLLPWDDVNNSDNPSGIRLGTQEC 369
Query: 372 TRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFDYG 422
TR+GM E EM+EIA FMKR+ +DKE P+KVR+DV F EY ++YSFD G
Sbjct: 370 TRLGMKEKEMEEIAEFMKRIAIDKEKPEKVREDVKEFAKEYSTIHYSFDEG 420
>sp|O27433|GLYA_METTH SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433545|pir||F69050 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622490|gb|AAB85857.1| (AE000901)
serine hydroxymethyltransferase [Methanobacterium
thermoautotrophicum]
Length = 428
Score = 444 bits (1130), Expect = e-124
Identities = 214/417 (51%), Positives = 296/417 (70%), Gaps = 9/417 (2%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
++Y +K+ +++H W +INLIASENITS V A+ S H+YAEG P +R Y+GC
Sbjct: 10 QDYTEKIRQLMKDHNSWMESSINLIASENITSSRVKEALLSDLSHRYAEGLPGERLYEGC 69
Query: 64 KYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHIS 123
+Y+DE+E + +EL +LF++++A+++P SG AN A FF + GD ++ + +GGHIS
Sbjct: 70 RYIDEIEELTIELSKRLFRAEHANVQPTSGVVANLACFFATAEVGDPIMAMEVPYGGHIS 129
Query: 124 HMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELA 183
H AAG+RG +++T PFD E+ NID D +K I E++P+I++FGGSLF FPHPV+E
Sbjct: 130 HARVSAAGVRGFQIYTHPFDFENMNIDADAMKKKILEVKPRIILFGGSLFLFPHPVEEAL 189
Query: 184 PVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFAD 243
A+EVGA ++YD AHVLGLIAGG FQDPLREGAD++ STHKTFPGPQGG+IL +
Sbjct: 190 EAAEEVGARIMYDGAHVLGLIAGGYFQDPLREGADMLVGSTHKTFPGPQGGIILCR---- 245
Query: 244 DETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEEG 303
+E A + A+FPG++SNHHLHH+AG I AEMLE+G YA Q + NA+ LAE L E G
Sbjct: 246 EELAADIDEAVFPGLVSNHHLHHVAGLGIATAEMLEFGAEYAAQTINNARKLAENLHELG 305
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSG 363
F V+ E +T+SHQV++DVSD+ A + LE IILNKNLLPWD + + ++PSG
Sbjct: 306 FNVLCEHLDFTESHQVVMDVSDIGRAAE--ISKRLEANNIILNKNLLPWDDVNRSDDPSG 363
Query: 364 LRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
+RIG QE+TR GM E EM E+A ++KRV++D +D VR +V F Y +V+Y+F+
Sbjct: 364 IRIGTQEITRRGMKESEMSEVAEYIKRVVMDGKD---VRDEVAEFMSSYTRVHYAFE 417
>emb|CAB57769.1| (Y18930) serine hydroxymethyltransferase [Sulfolobus solfataricus]
Length = 433
Score = 441 bits (1122), Expect = e-123
Identities = 229/422 (54%), Positives = 287/422 (67%), Gaps = 8/422 (1%)
Query: 1 MAYKEYRDKVLHFIEEHEKWR-SHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRY 59
M+ + +KVL + WR + T+NLIASEN+ SP S FM +YAEG P +RY
Sbjct: 1 MSLPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRY 60
Query: 60 YQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
YQG KY DE+E + +EL ++ S DLRP SGT AN AVF L +PGDK ++ G
Sbjct: 61 YQGTKYTDEIETLTMELMNEITNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAG 120
Query: 120 GHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
H+SH FG G G++ PFD E+ N+DVDKA KMI E++PK VV GGSL+ FPHP
Sbjct: 121 AHVSHTKFGTLGALGIQHIEMPFDEENINVDVDKAIKMIEEVKPKFVVLGGSLYLFPHPT 180
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
KELA VGA +VYDAAHV GLI G + +PL++GADIMT STHKTFPGPQGG I
Sbjct: 181 KELAQHVHAVGAKLVYDAAHVYGLIEGKVWSNPLKDGADIMTVSTHKTFPGPQGGAI--- 237
Query: 240 KFAD-DETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEA 298
F+D E ++ IFP +SNHHLH + +TA EM +GE+YA QI++N+KALAEA
Sbjct: 238 -FSDGSEVFKQVSKTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQILRNSKALAEA 296
Query: 299 LAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKV 358
LAE GFKVIGE+ GYTKSHQV VDV GG A LLE+A II+NKNLLP+D E V
Sbjct: 297 LAERGFKVIGENLGYTKSHQVAVDVRQF--GGGNKIAKLLEDANIIVNKNLLPYDKPEDV 354
Query: 359 NEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYS 418
++PSGLRIGVQEMTR GM E EM+EIA K+V++DK+D +V+K+V R + +V Y+
Sbjct: 355 SDPSGLRIGVQEMTRYGMKEGEMEEIAELFKKVIIDKKDVNEVKKEVIEMRRNFLEVKYT 414
Query: 419 FD 420
FD
Sbjct: 415 FD 416
>gb|AAK40850.1| Serine hydroxymethyltransferase (glyA) [Sulfolobus solfataricus]
Length = 433
Score = 441 bits (1122), Expect = e-123
Identities = 229/422 (54%), Positives = 287/422 (67%), Gaps = 8/422 (1%)
Query: 1 MAYKEYRDKVLHFIEEHEKWR-SHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRY 59
M+ + +KVL + WR + T+NLIASEN+ SP S FM +YAEG P +RY
Sbjct: 1 MSLPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRY 60
Query: 60 YQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
YQG KY DE+E + +EL ++ S DLRP SGT AN AVF L +PGDK ++ G
Sbjct: 61 YQGTKYTDEIETLTMELMNEITNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAG 120
Query: 120 GHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
H+SH FG G G++ PFD E+ N+DVDKA KMI E++PK VV GGSL+ FPHP
Sbjct: 121 AHVSHTKFGTLGALGIQHIEMPFDEENINVDVDKAIKMIEEVKPKFVVLGGSLYLFPHPT 180
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
KELA VGA +VYDAAHV GLI G + +PL++GADIMT STHKTFPGPQGG I
Sbjct: 181 KELAQHVHAVGAKLVYDAAHVYGLIEGKVWSNPLKDGADIMTVSTHKTFPGPQGGAI--- 237
Query: 240 KFAD-DETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEA 298
F+D E ++ IFP +SNHHLH + +TA EM +GE+YA QI++N+KALAEA
Sbjct: 238 -FSDGSEVFKQVSKTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQILRNSKALAEA 296
Query: 299 LAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKV 358
LAE GFKVIGE+ GYTKSHQV VDV GG A LLE+A II+NKNLLP+D E V
Sbjct: 297 LAERGFKVIGENLGYTKSHQVAVDVRQF--GGGNKIAKLLEDANIIVNKNLLPYDKPEDV 354
Query: 359 NEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYS 418
++PSGLRIGVQEMTR GM E EM+EIA K+V++DK+D +V+K+V R + +V Y+
Sbjct: 355 SDPSGLRIGVQEMTRYGMKEGEMEEIAELFKKVIIDKKDVNEVKKEVIEMRRNFLEVKYT 414
Query: 419 FD 420
FD
Sbjct: 415 FD 416
>sp|Q9YAH7|GLYA_AERPE SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433547|pir||D72498 probable serine
hydroxymethyltransferase APE1962 - Aeropyrum pernix
(strain K1) >gi|5105660|dbj|BAA80972.1| (AP000063) 442aa
long hypothetical serine hydroxymethyltransferase
[Aeropyrum pernix]
Length = 442
Score = 440 bits (1119), Expect = e-122
Identities = 216/413 (52%), Positives = 282/413 (67%), Gaps = 6/413 (1%)
Query: 9 KVLHFIEEHEKWR-SHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVD 67
K+ H WR +INLIASEN+ S + +A S FM +YAEG P +RYYQG +Y+D
Sbjct: 18 KIAELTTRHNVWRLRESINLIASENVMSLTALKAYLSDFMFRYAEGKPFKRYYQGTRYID 77
Query: 68 EVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPF 127
E+E++ EL + ++ +LRP+SGT AN +VF L +PGDK ++ G H+SH F
Sbjct: 78 ELEVLTGELMGSMMGTNLVELRPVSGTIANASVFRVLAEPGDKAVIAPVQAGAHVSHTKF 137
Query: 128 GAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAK 187
G G G+E + P+D E+ N+DVDKA K+I E++P+ V GGS++ FPHP +E+A
Sbjct: 138 GTLGALGIEQVSMPYDEENMNVDVDKAVKLIEEVKPRFAVLGGSVYIFPHPTREIAEAIH 197
Query: 188 EVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETI 247
VG ++YDAAHVLGLI GG + +PL GAD +T STHKTFPGPQGG + F D++
Sbjct: 198 SVGGKLIYDAAHVLGLIMGGAWPNPLERGADAVTGSTHKTFPGPQGGAVF---FRDEQLY 254
Query: 248 AKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVI 307
K+ IFP +SNHHLH + ITA EM YG YA Q+ NA+ LAEALA EG KVI
Sbjct: 255 KKVSKTIFPWWVSNHHLHRIPATAITAVEMKLYGRDYASQVTSNARKLAEALAAEGLKVI 314
Query: 308 GEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIG 367
GE GYT+SHQV+VDV DL GG A LLEE+ II+NKNLLPWDP E V +PSG+RIG
Sbjct: 315 GEHLGYTRSHQVVVDVRDL--GGGAKCASLLEESNIIVNKNLLPWDPPEAVKDPSGIRIG 372
Query: 368 VQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
VQE+TR+GM EM+EIA +++VL+DKEDPKKV + V FR ++ K++YS D
Sbjct: 373 VQEVTRLGMKHGEMEEIAKLIRKVLIDKEDPKKVAEQVKEFRKQFMKIHYSLD 425
>sp|P50436|GLYA_METTM SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|2127693|pir||S62190 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Methanobacterium thermoautotrophicum
(strain Marburg) >gi|1103705|emb|CAA63066.1| (X92083)
glycine hydroxymethyltransferase [Methanobacterium
thermoautotrophicum]
Length = 424
Score = 432 bits (1099), Expect = e-120
Identities = 211/412 (51%), Positives = 291/412 (70%), Gaps = 11/412 (2%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
++Y +++ +++H W +INLIASENITS V A+ S H+YAEG P +R Y+GC
Sbjct: 5 QDYTERIRDLMKDHNSWMESSINLIASENITSSRVKEALISDLSHRYAEGLPGERLYEGC 64
Query: 64 KYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHIS 123
+Y+DE+E I +EL KLF++++A+++P SG AN A FF GD ++ + +GGHIS
Sbjct: 65 RYIDEIEEITIELSKKLFRAEHANVQPTSGVVANLACFFATADVGDPMMAMEVPYGGHIS 124
Query: 124 HMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELA 183
H AAG+RG +++T PFD E+ NID D +K I E++P+I++FGGSLF FPHPV+E
Sbjct: 125 HAKVSAAGVRGFKIYTHPFDFENMNIDADAMKKKILEVKPRIILFGGSLFLFPHPVEEAV 184
Query: 184 PVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK-KFA 242
A+EVGA ++YD AHVLGLIAGG FQDPLREGAD++ STHKTFPGPQGG+IL + + A
Sbjct: 185 EAAEEVGARIMYDGAHVLGLIAGGYFQDPLREGADMLVGSTHKTFPGPQGGIILCREELA 244
Query: 243 DDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEE 302
DD + A+FPG++SNHHLHH+AG I AEMLE+G YA Q ++NAK LAE L E
Sbjct: 245 DD-----IDEAVFPGLVSNHHLHHVAGLGIATAEMLEFGSEYAAQTIRNAKKLAENLNEL 299
Query: 303 GFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPS 362
GF V+ E +T+SHQV++DVSD+ A + LE IILNKNLLPWD + + ++PS
Sbjct: 300 GFNVLCEHLDFTESHQVVMDVSDIGRAAE--ISKKLEANNIILNKNLLPWDDVNRSDDPS 357
Query: 363 GLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQK 414
G+RIG QE+TR GM E EM E+A ++K+V++ D + V+++V F Y +
Sbjct: 358 GIRIGTQEITRRGMKESEMSEVAEYIKKVVI---DGRNVKEEVSEFMSSYTR 406
>gi|11498458 serine hydroxymethyltransferase (glyA) [Archaeoglobus fulgidus]
>gi|3183016|sp|O29406|GLYA_ARCFU SERINE
HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433546|pir||D69356 serine hydroxymethyltransferase
(glyA) homolog - Archaeoglobus fulgidus
>gi|2649750|gb|AAB90386.1| (AE001045) serine
hydroxymethyltransferase (glyA) [Archaeoglobus fulgidus]
Length = 451
Score = 421 bits (1071), Expect = e-117
Identities = 211/411 (51%), Positives = 284/411 (68%), Gaps = 6/411 (1%)
Query: 10 VLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEV 69
V IE H K +I LIASEN+TS SV R S H+YAEG +R+Y+GCKYVD++
Sbjct: 36 VFQIIEGHTKLMRDSIPLIASENLTSLSVRRCYVSDLGHRYAEGRVGERFYEGCKYVDQI 95
Query: 70 ELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGA 129
E + +EL K+F++++A+++PISG AN A FF L GD ++ + GGHISH A
Sbjct: 96 ESMAIELTRKIFEAEHANVQPISGVVANLAAFFALTNVGDTIMSISVPCGGHISHDRVSA 155
Query: 130 AGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEV 189
AG+RGL V +PF++E ++DVD+ K+ PK+ + G SL F PVKE+ +A E+
Sbjct: 156 AGLRGLRVIHYPFNSEEMSVDVDETRKVAERERPKLFILGSSLILFRQPVKEIREIADEI 215
Query: 190 GAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAK 249
GA+V+YDA+HVLGLIAG FQ+PL+EGAD+MT STHKTF GPQ +I +K E K
Sbjct: 216 GAYVMYDASHVLGLIAGKAFQNPLKEGADVMTGSTHKTFFGPQRAIIASRK----ELAEK 271
Query: 250 LQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGE 309
+ A+FPGV+SNHHL+ +AG V+ A EMLE+GE YAKQ+V+NAKALAE L G+KV+GE
Sbjct: 272 VDRAVFPGVVSNHHLNTLAGYVVAAMEMLEFGEDYAKQVVRNAKALAEELYSLGYKVLGE 331
Query: 310 DQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQ 369
+G+T++HQV VDV + GG A +LE AGIILNKNLLPWD LEK PSG+RIGVQ
Sbjct: 332 KRGFTETHQVAVDVREF--GGGERVAKVLENAGIILNKNLLPWDSLEKTANPSGIRIGVQ 389
Query: 370 EMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
E+TR+GM E+EM+ IA M + +K+ ++R +V + + + YSFD
Sbjct: 390 EVTRIGMKEEEMRAIAEIMDAAIKEKKSVDELRNEVKELKERFNVIKYSFD 440
>emb|CAC12627.1| (AL445067) probable glycine hydroxymethyltransferase [Thermoplasma
acidophilum]
Length = 436
Score = 404 bits (1027), Expect = e-111
Identities = 215/419 (51%), Positives = 273/419 (64%), Gaps = 5/419 (1%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M+Y++ + + +H + I LIASEN+ SP + S +YAEG P RYY
Sbjct: 11 MSYED-AEYIREMAMKHSEMFGEGIALIASENVMSPLAKEVMISDLESRYAEGLPHHRYY 69
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
QG YVD +E EL +KLF++ D RPISGTNAN A + L PGD V S GG
Sbjct: 70 QGNYYVDLIEDRTNELLSKLFRTSQTDPRPISGTNANSAAIYALAGPGDLVATPSLSGGG 129
Query: 121 HISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK 180
HIS FG GMR + +P+D ++ ID D+A KMI + +PK+ +FG S+F FP P+K
Sbjct: 130 HISAAEFGILGMRSVRTINYPYDMDTMTIDPDQASKMIIKEKPKVCLFGQSVFMFPAPLK 189
Query: 181 ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK 240
E+A EVG V YD AHVLGLIAGG FQDPLREGADI+T STHKTFPGPQ GVIL
Sbjct: 190 EMAEAFHEVGCKVWYDGAHVLGLIAGGRFQDPLREGADIVTGSTHKTFPGPQHGVILGN- 248
Query: 241 FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALA 300
DDET ++ A+FPGVLSNHHL+ MA ITAAE LE+G+ YA I+ NAK LAE L
Sbjct: 249 -TDDETWKAVRRAVFPGVLSNHHLNAMAALGITAAEELEFGKRYADDIISNAKVLAEELY 307
Query: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE 360
GF V+ E +G+T+SH + VDVS GG + A LE+ GIILNKNLLPWD +K
Sbjct: 308 ANGFNVLAEKRGFTESHTMAVDVS--KNGGGKYVAETLEKCGIILNKNLLPWDDNKKSQN 365
Query: 361 PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEYQKVYYSF 419
PSG+RIGVQE TRVGM + EMKEIA + R ++ EDP+K++ +V + +++V Y +
Sbjct: 366 PSGIRIGVQEATRVGMGKSEMKEIASLITRAIIRHEDPEKIKAEVKQLKSGFREVKYCY 424
>sp|O66776|GLYA_AQUAE SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433536|pir||D70343 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Aquifex aeolicus
>gi|2983131|gb|AAC06734.1| (AE000692) serine
hydroxymethyl transferase [Aquifex aeolicus]
Length = 428
Score = 259 bits (656), Expect = 3e-68
Identities = 152/391 (38%), Positives = 237/391 (59%), Gaps = 12/391 (3%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
++E+E+ + + + +IASEN TS +V A S +KYAEG P +RYY GC+YVD VE +
Sbjct: 16 VKEYER-QFYNLEMIASENFTSLAVMEATGSVLTNKYAEGLPGKRYYGGCEYVDVVENLA 74
Query: 74 VELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMR 133
+E KLF +++A+++P SG+ AN AV+F + PGD ++ + +HGGH++H +
Sbjct: 75 IERAKKLFGAEHANVQPHSGSQANMAVYFAVLNPGDTIMGMDLAHGGHLTHGAKVNFSGK 134
Query: 134 GLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFV 193
V + + E+ ID D+ K+ +E +PK++V G S +P ++ +A EVGA
Sbjct: 135 LYNVIHYGVNPETELIDYDQLYKLAKEHKPKLIVGGASAYPRVFDWAKMREIADEVGALF 194
Query: 194 VYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWA 253
+ D AH GLIAGG + +P+ A +T++THKT GP+ G IL K E + +
Sbjct: 195 MVDMAHYAGLIAGGVYPNPV-PYAQFVTSTTHKTLRGPRSGFILTTK----EYAKAVDKS 249
Query: 254 IFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQG 312
+FPG+ +H +A K + E M E + YAKQ+V+NA+ LAE L + GFK++ G
Sbjct: 250 VFPGIQGGPLMHVIAAKAVAFKEAMSEEFKEYAKQVVENARVLAEELKKYGFKIV---TG 306
Query: 313 YTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMT 372
T SH V+VD+ + + G A LE+AGI +NKN +P+DPL + SG+RIG +T
Sbjct: 307 GTDSHIVLVDLRNKNIIGKD-AEKALEKAGITVNKNAVPFDPLPP-TKTSGIRIGTAALT 364
Query: 373 RVGMMEDEMKEIAHFMKRVLLDKEDPKKVRK 403
GM EDEM++IA ++ VL + +D K +++
Sbjct: 365 TRGMKEDEMRKIAGWINEVLSNMDDEKTIQR 395
>sp|P06192|GLYA_SALTY SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|477806|pir||B48427 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Salmonella typhimurium
>gi|47698|emb|CAA33808.1| (X15816) serine
hydroxymethyltransferase (AA 1-417) [Salmonella
typhimurium]
Length = 417
Score = 243 bits (614), Expect = 3e-63
Identities = 150/405 (37%), Positives = 231/405 (57%), Gaps = 11/405 (2%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M +Y ++ +E+ + + I LIASEN TSP V +A S +KYAEG+P +RYY
Sbjct: 6 MNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYY 65
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
GC+YVD VE + ++ +LF +DYA+++P SG+ AN AV+ L QPGD V+ ++ + GG
Sbjct: 66 GGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGG 125
Query: 121 HISHMPFGAAGMRGLEVHTWPFD-NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
H++H G + P+ +ES ID D+ K +E +PK+++ G S +
Sbjct: 126 HLTH--GSPVNFSGKLYNIVPYGIDESGKIDYDEMAKSAKEHKPKMIIGGFSAYSGVVDW 183
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
++ +A +GA++ D AHV GLIA G + +P+ A ++T +THKT GP+GG+IL
Sbjct: 184 AKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPH-AHVVTTTTHKTLAGPRGGLIL-A 241
Query: 240 KFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEA 298
K D+E KL A+FP +H +AGK + E +E + Y +Q+ KNAKA+ E
Sbjct: 242 KGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVGLKEAMEPEFKVYQQQVAKNAKAMVEV 301
Query: 299 LAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKV 358
G+KV+ G T++H ++D+ D + G A L A I +NKN +P DP +
Sbjct: 302 FLNRGYKVV---SGGTENHLFLLDLVDKNLTGKE-ADAALGRANITVNKNSVPNDP-KSP 356
Query: 359 NEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRK 403
SG+RIG +TR G E E+KE+A +M VL + D + +
Sbjct: 357 FVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEATIER 401
>gb|AAG19732.1| (AE005059) glycine hydroxymethyltransferase; GlyA [Halobacterium
sp. NRC-1]
Length = 424
Score = 242 bits (611), Expect = 6e-63
Identities = 153/412 (37%), Positives = 226/412 (54%), Gaps = 19/412 (4%)
Query: 1 MAYKEYRD---KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQ 57
MAY E R+ +V + ++ T+ +IASEN S +V A +S +KYAEG+P
Sbjct: 10 MAYDEVREVDPEVADALTGERHRQNDTLAMIASENHVSEAVMEAQSSELTNKYAEGYPGS 69
Query: 58 RYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTS 117
RYY GC+Y D+VE + V +LF +D+ +++P SG++AN V+F PGDK++ L +
Sbjct: 70 RYYGGCEYADDVEELAVARAKELFGADHVNVQPHSGSSANMGVYFATLAPGDKILSLDLT 129
Query: 118 HGGHISH-MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFP 176
HGGH+SH P AG EV + D E+ +D + + EP ++V G S +P
Sbjct: 130 HGGHLSHGHPANFAGQL-YEVEQYEVDAETGRLDYEALREHADAFEPDMIVSGFSAYPRE 188
Query: 177 HPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVI 236
+ + A VGA + D AH+ GL+A GE P+ AD +T STHKT +GG++
Sbjct: 189 VEWERIQAAADAVGALHMADIAHITGLVAAGEHASPVGV-ADFVTGSTHKTIRAGRGGIV 247
Query: 237 LY-KKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKA 294
+ + FADD + A+FPG +H++AGK + E L+ E YA Q+V+NA
Sbjct: 248 MCDEAFADD-----IDSAVFPGAQGGPLMHNIAGKAVGFNEALDPAFEEYAAQVVENAAV 302
Query: 295 LAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHP-AGGGWAAPLLEEAGIILNKNLLPWD 353
L E L E GF ++ G T +H V+VD+ + HP GG LE+ GI+LN N +P D
Sbjct: 303 LGERLQEHGFSLV---SGGTDTHLVLVDLRESHPDISGGDVEGELEDVGIVLNANTVP-D 358
Query: 354 PLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDV 405
+PSG+RIG +T G D M+ +A + RV +D + V DV
Sbjct: 359 ETRSAFDPSGIRIGTPALTTRGFDADAMETVADCIARV-IDNLGDESVYADV 409
>sp|P00477|GLYA_ECOLI SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|66481|pir||XYECS glycine hydroxymethyltransferase
(EC 2.1.2.1) - Escherichia coli >gi|6730324|pdb|1DFO|B
Chain B, Crystal Structure At 2.4 Angstrom Resolution Of
E. Coli Serine Hydroxymethyltransferase In Complex With
Glycine And 5-Formyl Tetrahydrofolate
>gi|6730323|pdb|1DFO|A Chain A, Crystal Structure At 2.4
Angstrom Resolution Of E. Coli Serine
Hydroxymethyltransferase In Complex With Glycine And
5-Formyl Tetrahydrofolate >gi|6730326|pdb|1DFO|D Chain
D, Crystal Structure At 2.4 Angstrom Resolution Of E.
Coli Serine Hydroxymethyltransferase In Complex With
Glycine And 5-Formyl Tetrahydrofolate
>gi|6730325|pdb|1DFO|C Chain C, Crystal Structure At 2.4
Angstrom Resolution Of E. Coli Serine
Hydroxymethyltransferase In Complex With Glycine And
5-Formyl Tetrahydrofolate >gi|41603|emb|CAA23547.1|
(V00283) reading frame glyA [Escherichia coli]
>gi|146218|gb|AAA23912.1| (J01620) serine
hydroxymethyltransferase [Escherichia coli]
>gi|1788902|gb|AAC75604.1| (AE000341) serine
hydroxymethyltransferase [Escherichia coli K12]
>gi|1799975|dbj|BAA16459.1| (D90885) SERINE
HYDROXYMETHYLTRANSFERASE (EC 2.1.2.1) (SERINE METHYLASE)
(SHMT). [Escherichia coli]
Length = 417
Score = 241 bits (608), Expect = 1e-62
Identities = 147/394 (37%), Positives = 226/394 (57%), Gaps = 11/394 (2%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M +Y ++ +E+ + + I LIASEN TSP V +A S +KYAEG+P +RYY
Sbjct: 6 MNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYY 65
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
GC+YVD VE + ++ +LF +DYA+++P SG+ AN AV+ L +PGD V+ ++ +HGG
Sbjct: 66 GGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLEPGDTVLGMNLAHGG 125
Query: 121 HISHMPFGAAGMRGLEVHTWPFD-NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
H++H G + P+ + + +ID EK +E +PK+++ G S +
Sbjct: 126 HLTH--GSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDW 183
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
++ +A +GA++ D AHV GL+A G + +P+ A ++T +THKT GP+GG+IL
Sbjct: 184 AKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPH-AHVVTTTTHKTLAGPRGGLIL-A 241
Query: 240 KFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEA 298
K +E KL A+FPG +H +AGK + E +E + Y +Q+ KNAKA+ E
Sbjct: 242 KGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEV 301
Query: 299 LAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKV 358
E G+KV+ G T +H +VD+ D + G A L A I +NKN +P DP +
Sbjct: 302 FLERGYKVV---SGGTDNHLFLVDLVDKNLTGKE-ADAALGRANITVNKNSVPNDP-KSP 356
Query: 359 NEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
SG+R+G +TR G E E KE+A +M VL
Sbjct: 357 FVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVL 390
>sp|Q9WZH9|GLYA_THEMA SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433556|pir||F72341 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Thermotoga maritima (strain MSB8)
>gi|4981245|gb|AAD35802.1|AE001743_4 (AE001743) serine
hydroxymethyltransferase [Thermotoga maritima]
Length = 427
Score = 240 bits (606), Expect = 2e-62
Identities = 146/392 (37%), Positives = 225/392 (57%), Gaps = 14/392 (3%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
K+ ++ + K + + + LIASEN S +V + S +KYAEG+P++RYY GC
Sbjct: 6 KQVDPEIYEVLVNELKRQEYGLELIASENFASLAVIETMGSMLTNKYAEGYPKKRYYGGC 65
Query: 64 KYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHIS 123
++VD E +E +LF + +A+++P SG+ AN AV+ L QPGD ++ + SHGGH++
Sbjct: 66 EWVDRAEERAIERAKRLFGAKFANVQPHSGSQANMAVYLALAQPGDTIMGMSLSHGGHLT 125
Query: 124 H-MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKEL 182
H P +G + +V + + E+ ID D+ ++ E +PKI+V GGS + K
Sbjct: 126 HGAPVNFSG-KIFKVVPYGVNLETETIDYDEVRRLALEHKPKIIVAGGSAYARIIDFKRF 184
Query: 183 APVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFA 242
+A EVGA+++ D AH GL+A G +PL E A ++T++THKT GP+GG+IL
Sbjct: 185 REIADEVGAYLMVDMAHFAGLVAAGIHPNPL-EYAHVVTSTTHKTLRGPRGGLIL----T 239
Query: 243 DDETIAK-LQWAIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQIVKNAKALAEALA 300
+D IAK + IFPG+ +H +A K + E M E + Y KQ+VKNAK +AE
Sbjct: 240 NDPEIAKAVDKTIFPGIQGGPLMHVIAAKAVCFKEAMTEEFKEYQKQVVKNAKKMAEEFQ 299
Query: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE 360
+ G++++ G T +H +VD++ G A LE GI +NKN +P +
Sbjct: 300 KRGYRIV---SGGTDTHLFLVDLTPKDITGKA-AEKALESCGITVNKNTIP-NEKRSPFV 354
Query: 361 PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
SG+RIG +T GM E+EM+EIA + VL
Sbjct: 355 ASGIRIGTPAVTTRGMKEEEMEEIAEMIDLVL 386
>sp|P57376|GLYA_BUCAI SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|10038964|dbj|BAB12999.1| (AP001118) serine
hydroxymethyltransferase [Buchnera sp. APS]
Length = 417
Score = 240 bits (605), Expect = 3e-62
Identities = 147/414 (35%), Positives = 239/414 (57%), Gaps = 12/414 (2%)
Query: 3 YKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQG 62
+ +Y K+ IE+ +K + + I LIASEN TS V S +KYAEG+P +RYY G
Sbjct: 8 FSKYDPKLWFAIEQEKKRQENHIELIASENYTSNYVMDVQGSQLTNKYAEGYPGKRYYGG 67
Query: 63 CKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHI 122
C+YVD +E + +E KLF +DYA+++P SG+ AN +V+ L PGD ++ + SHGGH+
Sbjct: 68 CEYVDIIEELAIERAKKLFNADYANVQPHSGSQANFSVYTALLNPGDTILGMKLSHGGHL 127
Query: 123 SHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKEL 182
+H + V ++ D E+ I+ ++ ++ ++ +PK+++ G S + K++
Sbjct: 128 THGSSVNFSGKMYNVISYGVD-ENGEINYEELLRLTKKYKPKMIIGGFSAYSGICNWKKM 186
Query: 183 APVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFA 242
+A A+ V D AHV GL+A G + +P+ A ++T++THKT GP+GG+IL K
Sbjct: 187 RFIADNADAYFVVDMAHVAGLVAAGIYPNPINY-AHVVTSTTHKTLAGPRGGLILAKN-G 244
Query: 243 DDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAE 301
DD KL ++FPG +H +A K I E LE + Y KQIVKN+K + E E
Sbjct: 245 DDILYKKLNLSVFPGAQGGPLMHVIAAKAIAFKEALEPKFKTYQKQIVKNSKVMVERFLE 304
Query: 302 EGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEP 361
+G+K+I G+T +H ++D+++ G A +L +A I +NKN +P D L+
Sbjct: 305 KGYKII---SGHTFNHLFLIDLTNKKITGKD-ADIILSKANITVNKNTIPND-LKSPFIT 359
Query: 362 SGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPK---KVRKDVYYFRLEY 412
SG+RIG +TR G E+E+ I+ ++ +L + +D +++K V L+Y
Sbjct: 360 SGIRIGTAAVTRRGFKENEVSRISDWITSILNNVDDHNNVLQIKKKVLEMCLKY 413
>sp|P34894|GLYA_ACTAC SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|421296|pir||S34379 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Actinobacillus actinomycetemcomitans
>gi|313832|emb|CAA80807.1| (Z23269) serine
hydroxymethyltransferase [Actinobacillus
actinomycetemcomitans]
Length = 420
Score = 239 bits (604), Expect = 4e-62
Identities = 148/407 (36%), Positives = 227/407 (55%), Gaps = 11/407 (2%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M +Y + IE + + I LIASEN SP V +A S F +KYAEG+P +RYY
Sbjct: 6 MNIADYDPVLWQAIENENRRQEEHIELIASENYASPRVMQAQGSQFTNKYAEGYPGKRYY 65
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
GC+Y D VE + +E +LF +DY +++P SG+ AN AV+ GL PGD ++ + +HGG
Sbjct: 66 GGCEYADIVEQLAIERAKELFGADYVNVQPHSGSQANAAVYMGLLNPGDTILGMSLAHGG 125
Query: 121 HISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVK 180
H++H + + + +E ID D K +++PK++V G S + K
Sbjct: 126 HLTHGASVSFSGKIYHAEQYGITDEGL-IDYDALRKQAHDVKPKMIVGGFSAYSQVVDWK 184
Query: 181 ELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK 240
++ +A EVGA++ D AHV GL+A G + +PL A ++T +THKT GP+GG+IL
Sbjct: 185 KMREIADEVGAYLFVDMAHVAGLVAAGIYPNPL-PYAHVVTTTTHKTLGGPRGGLIL-SS 242
Query: 241 FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEAL 299
D+E KL A+FP +H +A K + E LE + Y + ++KNAKA+ E
Sbjct: 243 CGDEEIYKKLNSAVFPAGQGGPLVHIIAAKAVCFKEALEPEYKVYQQNVLKNAKAMVEVF 302
Query: 300 AEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVN 359
+ +KV+ T++H +VD+ H G A L +A I +NKN +P DP +K
Sbjct: 303 KQRCYKVVSNG---TENHLFLVDLVS-HGLTGKAADAALGKANITVNKNSVPNDP-QKPF 357
Query: 360 EPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL--LDKEDPKKVRKD 404
SG+R+G +TR G E ++KE+A +M VL + K++ +V D
Sbjct: 358 ITSGIRVGTPSVTRRGFNEADVKELAGWMCDVLDAIGKDNEAEVIAD 404
>pdb|1EQB|B Chain B, X-Ray Crystal Structure At 2.7 Angstroms Resolution Of
Ternary Complex Between The Y65f Mutant Of E-Coli Serine
Hydroxymethyltransferase, Glycine And 5-Formyl
Tetrahydrofolate >gi|7767017|pdb|1EQB|A Chain A, X-Ray
Crystal Structure At 2.7 Angstroms Resolution Of Ternary
Complex Between The Y65f Mutant Of E-Coli Serine
Hydroxymethyltransferase, Glycine And 5-Formyl
Tetrahydrofolate >gi|7767019|pdb|1EQB|C Chain C, X-Ray
Crystal Structure At 2.7 Angstroms Resolution Of Ternary
Complex Between The Y65f Mutant Of E-Coli Serine
Hydroxymethyltransferase, Glycine And 5-Formyl
Tetrahydrofolate >gi|7767020|pdb|1EQB|D Chain D, X-Ray
Crystal Structure At 2.7 Angstroms Resolution Of Ternary
Complex Between The Y65f Mutant Of E-Coli Serine
Hydroxymethyltransferase, Glycine And 5-Formyl
Tetrahydrofolate
Length = 417
Score = 239 bits (604), Expect = 4e-62
Identities = 146/394 (37%), Positives = 226/394 (57%), Gaps = 11/394 (2%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M +Y ++ +E+ + + I LIASEN TSP V +A S +KYAEG+P +RY+
Sbjct: 6 MNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYF 65
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
GC+YVD VE + ++ +LF +DYA+++P SG+ AN AV+ L +PGD V+ ++ +HGG
Sbjct: 66 GGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLEPGDTVLGMNLAHGG 125
Query: 121 HISHMPFGAAGMRGLEVHTWPFD-NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
H++H G + P+ + + +ID EK +E +PK+++ G S +
Sbjct: 126 HLTH--GSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDW 183
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
++ +A +GA++ D AHV GL+A G + +P+ A ++T +THKT GP+GG+IL
Sbjct: 184 AKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPH-AHVVTTTTHKTLAGPRGGLIL-A 241
Query: 240 KFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEA 298
K +E KL A+FPG +H +AGK + E +E + Y +Q+ KNAKA+ E
Sbjct: 242 KGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEV 301
Query: 299 LAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKV 358
E G+KV+ G T +H +VD+ D + G A L A I +NKN +P DP +
Sbjct: 302 FLERGYKVV---SGGTDNHLFLVDLVDKNLTGKE-ADAALGRANITVNKNSVPNDP-KSP 356
Query: 359 NEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
SG+R+G +TR G E E KE+A +M VL
Sbjct: 357 FVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVL 390
>sp|P34895|GLYA_HYPME SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|424015|pir||S30334 glycine hydroxymethyltransferase
(EC 2.1.2.1) [validated] - Hyphomicrobium methylovorum
>gi|286031|dbj|BAA02884.1| (D13739) serine
hydroxymethyltransferase precursor [Hyphomicrobium
methylovorum]
Length = 434
Score = 239 bits (603), Expect = 5e-62
Identities = 147/374 (39%), Positives = 208/374 (55%), Gaps = 12/374 (3%)
Query: 21 RSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKL 80
+ H I LIASENI S +V A S +KYAEG+P +RYY GC+YVD VE I ++ KL
Sbjct: 38 QQHEIELIASENIVSQAVLDAAGSVLTNKYAEGYPGKRYYGGCQYVDIVEDIAIDRAKKL 97
Query: 81 FKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MPFGAAGMRGLEVHT 139
F ++A+++P SG+ ANQ VF L QPGD ++ L + GGH++H P +G VH
Sbjct: 98 FNCEFANVQPNSGSQANQGVFNALAQPGDTILGLSLAAGGHLTHGAPVNQSGKWFKAVH- 156
Query: 140 WPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAH 199
+ +S ID+D+ K+ +E +P+I++ GGS +P +A EVGA + D AH
Sbjct: 157 YMVKPDSHLIDMDEVRKLAQEHKPRIIIAGGSAYPRKIDFAAFRAIADEVGAIFLVDMAH 216
Query: 200 VLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVL 259
GL+A G P A ++T +THKT GP+GG+IL D + K+ AIFPG+
Sbjct: 217 FAGLVAAGLIPSPFPH-AHVVTTTTHKTLRGPRGGMILTN---DADIAKKINSAIFPGIQ 272
Query: 260 SNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQ 318
+H +AGK + E L + Y KQ++ NA+AL E L + GF ++ G T +H
Sbjct: 273 GGPLMHVIAGKAVAFGEALRPDFKVYIKQVMDNARALGEVLVQNGFALV---SGGTDTHL 329
Query: 319 VIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMME 378
V+VD+ G A L A I NKN +P+DP EK SG+R+G T G
Sbjct: 330 VLVDLRP-KKLTGTKAEKALGRANITCNKNGIPFDP-EKPMVTSGIRLGSPAGTTRGFGV 387
Query: 379 DEMKEIAHFMKRVL 392
E +EI + VL
Sbjct: 388 AEFQEIGRLISEVL 401
>sp|P39148|GLYA_BACSU SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|2117693|pir||I40483 glycine hydroxymethyltransferase
(EC 2.1.2.1) glyA - Bacillus subtilis
>gi|556886|emb|CAA86110.1| (Z38002) serine
hydroxymethyltransferase [Bacillus subtilis]
>gi|2636215|emb|CAB15707.1| (Z99122) serine
hydroxymethyltransferase [Bacillus subtilis]
>gi|1095424|prf||2108403J Ser hydroxymethyltransferase
[Bacillus subtilis]
Length = 415
Score = 238 bits (602), Expect = 7e-62
Identities = 143/398 (35%), Positives = 231/398 (57%), Gaps = 13/398 (3%)
Query: 8 DKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVD 67
++V + I+ + + I LIASEN S +V A S +KYAEG+P +RYY GC++VD
Sbjct: 9 EQVFNAIKNERERQQTKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVD 68
Query: 68 EVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MP 126
VE I + ++F +++ +++P SG AN AV+F + + GD V+ ++ SHGGH++H P
Sbjct: 69 VVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSP 128
Query: 127 FGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVA 186
+G++ V + D E+ ID D + +PK++V G S +P K+ +A
Sbjct: 129 VNFSGVQYNFVE-YGVDKETQYIDYDDVREKALAHKPKLIVAGASAYPRTIDFKKFREIA 187
Query: 187 KEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDET 246
EVGA+ + D AH+ GL+A G +P+ AD +T +THKT GP+GG+IL + +E
Sbjct: 188 DEVGAYFMVDMAHIAGLVAAGLHPNPV-PYADFVTTTTHKTLRGPRGGMILCR----EEF 242
Query: 247 IAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFK 305
K+ +IFPG+ +H +A K ++ E+L+ + YA+ ++ NAK LAEAL +EG +
Sbjct: 243 GKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQDDFKTYAQNVISNAKRLAEALTKEGIQ 302
Query: 306 VIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLR 365
++ G T +H ++VD+ L G A +L+E GI NKN +P+DP EK SG+R
Sbjct: 303 LV---SGGTDNHLILVDLRSL-GLTGKVAEHVLDEIGITSNKNAIPYDP-EKPFVTSGIR 357
Query: 366 IGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRK 403
+G +T G D ++E+ + L + ED K+ +
Sbjct: 358 LGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGKLEE 395
>sp|P77962|GLYA_SYNY3 SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433534|pir||S75210 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Synechocystis sp. (strain PCC 6803)
>gi|1652200|dbj|BAA17124.1| (D90903) serine
hydroxymethyltransferase [Synechocystis sp.]
Length = 427
Score = 237 bits (599), Expect = 2e-61
Identities = 146/393 (37%), Positives = 220/393 (55%), Gaps = 13/393 (3%)
Query: 8 DKVLHFIEEHEKWRSHT-INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYV 66
D L I + E R T I LIASEN TS +V A S +KYAEG P +RYY GC++V
Sbjct: 13 DPALAAIIDRELQRQRTHIELIASENFTSAAVMAAQGSVLTNKYAEGLPGKRYYGGCEFV 72
Query: 67 DEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-M 125
D+ E + + +LF + +A+++P SG AN AVF L QPGD ++ + SHGGH++H
Sbjct: 73 DQAETLAISRVKELFGAAHANVQPHSGAQANFAVFLTLLQPGDTIMGMDLSHGGHLTHGS 132
Query: 126 PFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPV 185
P +G + EV + + E+ +D DK + E++PK+++ G S +P + +
Sbjct: 133 PVNVSG-KWFEVAHYGVEKETGRLDYDKIRQQALEVKPKLLICGYSAYPRQIEFDKFRAI 191
Query: 186 AKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDE 245
A EVGA+++ D AH+ GL+A G PL D++T +THKT GP+GG+I+ ++E
Sbjct: 192 ADEVGAYLMADIAHIAGLVASGHHPSPL-PYCDVVTTTTHKTLRGPRGGLIMTN---NEE 247
Query: 246 TIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGF 304
K ++FPG H + K + E L+ + Y+ Q++ NA+A+A+ L + GF
Sbjct: 248 LGKKFDKSVFPGTQGGPLEHVITAKAVAFGEALKPEFKVYSGQVIANAQAMADQLQKRGF 307
Query: 305 KVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGL 364
++ G T +H ++VD+ + G LL E I NKN +P+DP E SGL
Sbjct: 308 DLV---SGGTDNHLMLVDLRSI-AMTGKVGDQLLGEINITANKNTVPFDP-ESPFVTSGL 362
Query: 365 RIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKED 397
R+G MT GM EDE + IA+ + LL ED
Sbjct: 363 RLGSPAMTTRGMQEDEFRTIANIIADRLLSPED 395
>sp|O08370|GLYA_RICPR SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433542|pir||C71634 glycine hydroxymethyltransferase
(EC 2.1.2.1) RP743 - Rickettsia prowazekii
>gi|2073491|emb|CAA72453.1| (Y11778) serine
hydroxymethyltransferase [Rickettsia prowazekii]
>gi|3861272|emb|CAA15171.1| (AJ235273) SERINE
HYDROXYMETHYLTRANSFERASE (glyA) [Rickettsia prowazekii]
Length = 420
Score = 235 bits (593), Expect = 8e-61
Identities = 150/420 (35%), Positives = 231/420 (54%), Gaps = 18/420 (4%)
Query: 8 DKVLHFIEEHEKWR-SHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYV 66
DK ++ I ++EK R ++ I LIASEN S +V A S +KYAEG+P +R+Y GC V
Sbjct: 12 DKEIYEIIKNEKIRQNNVIELIASENFVSSAVLEAQGSILTNKYAEGYPSKRFYNGCDEV 71
Query: 67 DEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMP 126
D+ E++ +E KLF YA+++P SG+ ANQ V+ L QP D ++ + GGH++H
Sbjct: 72 DKAEVLAIERIKKLFNCKYANVQPHSGSQANQTVYLALLQPCDTILGMSLDSGGHLTHGA 131
Query: 127 FGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVA 186
+ ++ D E++ ID D+ E++ PK+++ G S +P + +A
Sbjct: 132 APNISGKWFNTVSYHVDQETYLIDYDEVERLAVLHNPKLLIAGFSAYPRKIDFAKFRKIA 191
Query: 187 KEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDET 246
+VGA+++ D AH+ GL+A GE Q P+ A ++T++THKT GP+GG+IL +DDE
Sbjct: 192 DKVGAYLMADIAHIAGLVATGEHQSPI-PYAHVVTSTTHKTLRGPRGGLIL----SDDEE 246
Query: 247 IA-KLQWAIFPGVLSNHHLHHMAGKVITAAEML--EYGEAYAKQIVKNAKALAEALAEEG 303
I K+ A+FPG+ +H +A K + E L EY + Y KQ++ NAKALA +L E G
Sbjct: 247 IGKKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEY-KNYIKQVISNAKALAISLQERG 305
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSG 363
+ ++ G T +H V+VD+ G AA L+ AGI NKN +P+D SG
Sbjct: 306 YDIL---TGGTDNHIVLVDLRK-DGITGKCAANSLDRAGITCNKNAIPFDTTSPF-ITSG 360
Query: 364 LRIGVQEMTRVGMMEDEMKEIAHFMKRV---LLDKEDPKKVRKDVYYFRLEYQKVYYSFD 420
+R G T G E + I H + + L ED K + V + K++ +D
Sbjct: 361 IRFGTPACTTKGFKEKDFVLIGHMVAEILDGLKHNEDNSKTEQKVLSEVKKLMKLFPFYD 420
>pir||H82258 serine hydroxymethyltransferase VC0941 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9655400|gb|AAF94103.1|
(AE004177) serine hydroxymethyltransferase [Vibrio
cholerae]
Length = 435
Score = 235 bits (593), Expect = 8e-61
Identities = 143/394 (36%), Positives = 221/394 (55%), Gaps = 12/394 (3%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M +Y ++ I+E + I LIASEN TSP V +A S +KYAEG+P +RYY
Sbjct: 25 MNIADYDPELYAAIQEETLRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYY 84
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
GC+YVD+ E + ++ +LF +YA+++P SG+ AN AV+ L PGD V+ + +HGG
Sbjct: 85 GGCEYVDKAEALAIDRACQLFGCEYANVQPHSGSQANSAVYMALLNPGDTVLGMSLAHGG 144
Query: 121 HISHMPFGAAGMRGLEVHTWPFD-NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
H++H G + P+ +E+ I+ D+ E + E +PK+++ G S +
Sbjct: 145 HLTH--GSPVNFSGKHYNVIPYGIDEAGQINYDEMEALALEHKPKMIIGGFSAYSQIVDW 202
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
K + +A +VGA++ D AHV GLIA G + P+ A ++T +THKT GP+GG+IL
Sbjct: 203 KRMREIADKVGAYLFVDMAHVAGLIAAGVYPSPV-PFAHVVTTTTHKTLAGPRGGLILSN 261
Query: 240 KFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEA 298
A +E KL A+FPG +H +A K + E +E + Y ++VKNAKA+
Sbjct: 262 --AGEEMYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEAMEPEFKEYQARVVKNAKAMVAQ 319
Query: 299 LAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKV 358
E G+K++ T++H +VD+ D + G A L A I +NKN +P DP
Sbjct: 320 FQERGYKIVSNS---TENHLFLVDLIDKNITGKE-ADAALGAANITVNKNSVPNDPRSPF 375
Query: 359 NEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
SG+R+G +TR G E + K++A++M VL
Sbjct: 376 -VTSGIRVGTPAITRRGFTEQDAKDLANWMCDVL 408
>pir||C83341 serine hydroxymethyltransferase PA2444 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9948491|gb|AAG05832.1|AE004671_8 (AE004671) serine
hydroxymethyltransferase [Pseudomonas aeruginosa]
Length = 418
Score = 234 bits (591), Expect = 1e-60
Identities = 139/395 (35%), Positives = 226/395 (57%), Gaps = 9/395 (2%)
Query: 6 YRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKY 65
Y D++L ++ ++ + I LIASEN S V +A G +KYAEG+P +RYY GC++
Sbjct: 11 YDDELLAAMDAEDRRQEDHIELIASENYASKRVMQAQGGGLTNKYAEGYPGKRYYGGCEH 70
Query: 66 VDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHM 125
VD+VE + ++ +LF +DYA+++P SG++AN AV+ L GD ++ + +HGGH++H
Sbjct: 71 VDKVERLAIDRARQLFGADYANVQPHSGSSANAAVYLALLNAGDTILGMSLAHGGHLTHG 130
Query: 126 PFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPV 185
++ + + D + ID D+ E++ E +PK++V G S + +
Sbjct: 131 AKVSSSGKLYNAVQYGLDTATGLIDYDEVERLAVEHKPKMIVAGFSAYSKTLDFPRFRAI 190
Query: 186 AKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDE 245
A +VGA + D AHV GL+A G + +P+ AD++T +THKT GP+GG+IL + A++E
Sbjct: 191 ADKVGALLFVDMAHVAGLVAAGLYPNPI-PFADVVTTTTHKTLRGPRGGLILAR--ANEE 247
Query: 246 TIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGF 304
KL A+FPG +H +A K + E LE G + Y Q+++NAKA+AE G+
Sbjct: 248 IEKKLNSAVFPGAQGGPLMHVIAAKAVCFKEALEPGFKDYQAQVIRNAKAMAEVFIGRGY 307
Query: 305 KVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGL 364
V+ G T +H +++ + G A L A I +NKN +P DP + SG+
Sbjct: 308 DVV---SGGTDNHLMLISLVKQGLTGKA-ADAALGAAHITVNKNAVPNDP-QSPFVTSGI 362
Query: 365 RIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPK 399
RIG +T G E E +E+A ++ +L D ++P+
Sbjct: 363 RIGTPAVTTRGFREGECRELAGWICDILDDIDNPE 397
>pir||G82968 serine hydroxymethyltransferase PA5415 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951742|gb|AAG08800.1|AE004954_2 (AE004954) serine
hydroxymethyltransferase [Pseudomonas aeruginosa]
Length = 417
Score = 234 bits (590), Expect = 2e-60
Identities = 138/388 (35%), Positives = 223/388 (56%), Gaps = 9/388 (2%)
Query: 6 YRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKY 65
Y D++L ++ E + + LIASEN TS V +A SG +KYAEG+P +RYY GC++
Sbjct: 11 YDDELLAAMDAEEARQEDHLELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEH 70
Query: 66 VDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHM 125
VD+VE + ++ +LF +DYA+++P SG++AN AV+ L GD ++ + +HGGH++H
Sbjct: 71 VDKVERLAIDRARQLFGADYANVQPHSGSSANAAVYLALLNAGDTILGMSLAHGGHLTHG 130
Query: 126 PFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPV 185
++ + + D + ID D+ E++ E +PK++V G S + +
Sbjct: 131 AKVSSSGKLYNAVQYGLDTATGLIDYDEVERLAVEHKPKMIVAGFSAYSKTLDFPRFRAI 190
Query: 186 AKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDE 245
A +VGA + D AHV GL+A G + +P+ AD++T +THKT GP+GG+IL + A++E
Sbjct: 191 ADKVGALLFVDMAHVAGLVAAGLYPNPI-PFADVVTTTTHKTLRGPRGGLILAR--ANEE 247
Query: 246 TIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGF 304
KL A+FPG +H +A K + E LE G + Y Q+++NAKA+AE G+
Sbjct: 248 IEKKLNSAVFPGAQGGPLMHVIAAKAVCFKEALEPGFKDYQAQVIRNAKAMAEVFIGRGY 307
Query: 305 KVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGL 364
V+ G T +H +++ + G A L GI +NKN +P DP + SG+
Sbjct: 308 DVV---SGGTDNHLMLISLV-RQGLTGKEADAALGRVGITVNKNAVPNDP-QSPFVTSGI 362
Query: 365 RIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
RIG +T G+ E + +E+A ++ +L
Sbjct: 363 RIGTPAITTRGLQEAQSRELAGWICDIL 390
>pir||F75567 serine hydroxymethyltransferase - Deinococcus radiodurans (strain
R1) >gi|6457697|gb|AAF09629.1|AE001867_4 (AE001867)
serine hydroxymethyltransferase [Deinococcus
radiodurans]
Length = 436
Score = 233 bits (589), Expect = 2e-60
Identities = 147/400 (36%), Positives = 230/400 (56%), Gaps = 20/400 (5%)
Query: 8 DKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVD 67
D V I + + + + LIASEN TS +V A S +KYAEG+P +R+Y GC+ VD
Sbjct: 41 DAVFDLIAQEAERQRTGLELIASENFTSAAVREAQGSVLTNKYAEGYPGKRWYGGCEVVD 100
Query: 68 EVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MP 126
+VE + ++ +LF +++A+++P SG++AN AV+ L QPGD V+ + SHGGH++H
Sbjct: 101 QVEQLAIDRVKQLFNAEWANVQPHSGSSANLAVYNALIQPGDTVLGMDLSHGGHLTHGNK 160
Query: 127 FGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVA 186
+GMR ++ + D E+ ID+++ ++ E +PK+++ G S + +A
Sbjct: 161 ANFSGMR-YQMVAYQLDRETERIDMEEVRRLAHEHKPKMIIAGASAYSRVIDFAAFREIA 219
Query: 187 KEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDET 246
EVGA + D AH+ GLIA GE + L A ++ ++THKT GP+GG+IL A+D
Sbjct: 220 DEVGALLFADIAHIAGLIAAGEHPNALPH-AHVVASTTHKTLRGPRGGIIL----ANDPE 274
Query: 247 IAK-LQWAIFPGVLSNHHLHHMAGKVITAAEML--EYGEAYAKQIVKNAKALAEALAEEG 303
IAK L +FPG H +A K + E L E+ + YA+QI+KNA+ALA ++G
Sbjct: 275 IAKQLDRTVFPGYQGGPLEHVIAAKAVAFGEALRPEFKD-YARQIIKNAQALAGEFQQKG 333
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEP 361
++V+ G T +H ++ DL P G G A LL+ I ++K+ LP+D EK+
Sbjct: 334 YRVV---SGGTDNHLFLL---DLRPQGLNGTKATRLLDANHITISKSTLPYD-TEKILHG 386
Query: 362 SGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKV 401
G+RIG +T GM E M ++A + R L ++ KV
Sbjct: 387 GGIRIGTPAVTTRGMTEAHMTQVADLIDRALKGEDVQAKV 426
>sp|P24060|GLYA_BRAJA SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|95152|pir||S15203 glycine hydroxymethyltransferase
(EC 2.1.2.1) [validated] - Bradyrhizobium japonicum
>gi|39531|emb|CAA38450.1| (X54638) glycine
hydroxymethyltransferase [Bradyrhizobium japonicum]
Length = 432
Score = 233 bits (588), Expect = 3e-60
Identities = 147/375 (39%), Positives = 210/375 (55%), Gaps = 18/375 (4%)
Query: 23 HTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFK 82
H + LIASENI S +V A S +KYAEG+P YY GC++VD E + ++ KLF
Sbjct: 38 HEVELIASENIVSRAVLEAQGSVMTNKYAEGYPGALYYGGCEWVDVAENLAIDRAKKLFG 97
Query: 83 SDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MPFGAAGMRGLEVHTWP 141
+ +A+++P SG+ NQAVF L QPGD + L + GGH++H P +G H +
Sbjct: 98 AGFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLAAGGHLTHGSPVNMSGKWFKAAH-YT 156
Query: 142 FDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVL 201
E ID+D +K E++PK++V GGS + K +A VGA+++ D AH
Sbjct: 157 VRREDQIIDMDAVQKQAEEIKPKLIVAGGSAYSRAWDFKRFREIADSVGAYLLVDMAHFA 216
Query: 202 GLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIA-KLQWAIFPGVLS 260
GL+AGG P+ A + T +THK+ GP+GG+IL ++DET+A KL AIFPG+
Sbjct: 217 GLVAGGVHASPV-PYAHVTTTTTHKSLRGPRGGLIL----SNDETLAKKLNSAIFPGLQG 271
Query: 261 NHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQV 319
+H +A K + E L + YAK +V+NAKALAEA+ GF ++ G T +H +
Sbjct: 272 GPLMHVIAAKAVAFGEALRPDFKVYAKNVVENAKALAEAMKSHGFDIV---SGGTDNHLM 328
Query: 320 IVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMM 377
+V DL P G G + L A I NKN +P+DP EK SGLR+G T G
Sbjct: 329 LV---DLRPKGLKGNVSEKALVRAAITCNKNGIPFDP-EKPFVTSGLRLGTPAATTRGFG 384
Query: 378 EDEMKEIAHFMKRVL 392
E +++ + VL
Sbjct: 385 VAEFQQVGGMIAEVL 399
>pir||S30382 glycine hydroxymethyltransferase (EC 2.1.2.1) [similarity] -
Bacillus stearothermophilus
Length = 400
Score = 233 bits (587), Expect = 4e-60
Identities = 151/395 (38%), Positives = 222/395 (55%), Gaps = 16/395 (4%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHT-INLIASENITSPSVNRAVASGFMHKYAEGWPRQRY 59
M Y +D + E E+ R H I LIASEN S +V A S +KYAEG+P +RY
Sbjct: 1 MNYLPQQDPQVFAAIEQERKRQHAKIELIASENFVSRAVMEAQGSVLTNKYAEGYPGRRY 60
Query: 60 YQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
Y GC+YVD VE + E +LF +++A+++P SG AN AV+F + + GD V+ ++ SHG
Sbjct: 61 YGGCEYVDIVEELARERAKQLFGAEHANVQPHSGAQANMAVYFTVLEHGDTVLGMNLSHG 120
Query: 120 GHISH-MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHP 178
GH++H P +G++ V P E+ ID D R PK++V G S +P
Sbjct: 121 GHLTHGSPVNFSGVQYNFVAGVP---ETHVIDYDDVRIKARFHRPKLIVAGASAYPRIID 177
Query: 179 VKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILY 238
+ +A EVGA+++ D AH+ GL+A G +P+ A +T +THKT GP+GG+IL
Sbjct: 178 FAKFREIADEVGAYLMVDMAHIAGLVAAGLHPNPV-PYAHFVTTTTHKTLRGPRGGLIL- 235
Query: 239 KKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAE 297
++ ++ AIF G+ +H +A K + E L+ +AYAK++V NAK LA
Sbjct: 236 ---CQEQFAKQIDKAIFQGIQGGPLMHVIAAKAVAFGEALQDDFKAYAKRVVDNAKRLAS 292
Query: 298 ALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEK 357
AL EGF ++ G T +H ++VD+ G A +L+E GI +NKN +P+DP E
Sbjct: 293 ALQNEGFTLV---SGGTDNHLLLVDLRP-QQLTGKTAEKVLDEVGITVNKNTIPYDP-ES 347
Query: 358 VNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
SG+RIG +T G +EM EIA + VL
Sbjct: 348 PFVTSGIRIGTAAVTTRGFGLEEMDEIAAIIGLVL 382
>sp|O85718|GLYA_ACIRA SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|3284000|gb|AAC25425.1| (AF073769) serine
hydroxymethyltransferase [Acinetobacter radioresistens]
Length = 417
Score = 232 bits (585), Expect = 7e-60
Identities = 142/395 (35%), Positives = 226/395 (56%), Gaps = 11/395 (2%)
Query: 5 EYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCK 64
E+ ++ I + + I LIASEN SP+V A S +KYAEG+P +RYY GC+
Sbjct: 9 EFDPELAQAITNEDARQEAHIELIASENYCSPAVMEAQGSKLTNKYAEGYPGKRYYGGCE 68
Query: 65 YVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
YVD +E + ++ +LF +DYA+++P +G+ AN AV+ L PGD V+ + +HGGH++H
Sbjct: 69 YVDIIEQLAIDRAKELFGADYANVQPHAGSQANSAVYLALLNPGDTVLGMSLAHGGHLTH 128
Query: 125 MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAP 184
+ + + + E+ ID ++ E++ E +P+++V G S + +
Sbjct: 129 GAKVSFSGKTYNAIQYGLNPETGEIDYEEVERLALEHKPRMIVAGFSAYSQIVDWQRFRD 188
Query: 185 VAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADD 244
+A ++GA++ D AHV GL+A G + +P+ + AD+ T +THKT GP+ G+IL K A++
Sbjct: 189 IADKIGAYLFVDMAHVAGLVAAGVYPNPV-QIADVTTTTTHKTLRGPRSGLILAK--ANE 245
Query: 245 ETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEML--EYGEAYAKQIVKNAKALAEALAEE 302
E KLQ A+FPG +H +A K I E + EY +AY +Q+VKNA+A+AE L E
Sbjct: 246 EIEKKLQSAVFPGNQGGPLVHAVAAKAICFKEAMAPEY-KAYQQQVVKNAQAMAEVLIER 304
Query: 303 GFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPS 362
G+ V+ G TK+H ++ + G A L A I +NKN +P DP S
Sbjct: 305 GYDVV---SGGTKNHLFLLSLIKQDITGKD-ADAWLGAAHITVNKNSVPNDPRSPF-VTS 359
Query: 363 GLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKED 397
G+RIG +T G E E++++A ++ +L K D
Sbjct: 360 GIRIGTPAVTTRGFGEAEVRDLASWIADILDSKGD 394
>sp|O51547|GLYA_BORBU SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433533|pir||H70174 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Lyme disease spirochete
>gi|2688518|gb|AAC66951.1| (AE001161) serine
hydroxymethyltransferase (glyA) [Borrelia burgdorferi]
Length = 417
Score = 231 bits (584), Expect = 9e-60
Identities = 141/415 (33%), Positives = 222/415 (52%), Gaps = 22/415 (5%)
Query: 8 DKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVD 67
D++ + IE+ + I LIASEN TS + +AV S +KYAEG+P RYY GC ++D
Sbjct: 4 DQIFNLIEKEKLREREHIELIASENFTSLEIRQAVGSILTNKYAEGYPLNRYYGGCSFID 63
Query: 68 EVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPF 127
E+E + + +LF + YA+++P SG+ AN A L PGD+++ + SHGGH++H
Sbjct: 64 EIETLAISRAKELFGAKYANVQPHSGSQANMAAIMALISPGDRILGMQLSHGGHLTH--G 121
Query: 128 GAAGMRGLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPV 185
G+ +T+ + +S ID D+ K+ ++ P +++ G S + K+ +
Sbjct: 122 SRVNFSGIFFNTYFYGVSRDSELIDYDEVLKIAKDCRPNLIIAGASSYSREIDFKKFREI 181
Query: 186 AKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFAD-- 243
A +V A+++ D AH+ GLI G F + + A + T++THKT GP+GG+IL K D
Sbjct: 182 ADDVSAYLLCDIAHIAGLIVAG-FHNSSIDVAHLTTSTTHKTLRGPRGGIILSGKDFDKL 240
Query: 244 -------DETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEML-EYGEAYAKQIVKNAKAL 295
+ +FPG +H +AGK I E L E + Y ++KN K +
Sbjct: 241 VNFNGKEKPLFNAVNSTVFPGTQGGPLVHVIAGKAIAFKEALQESFKEYIANVIKNTKVM 300
Query: 296 AEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPL 355
AE EGF+++ G T +H +VD+S G A LLE I LNKN +P+D
Sbjct: 301 AEYFKSEGFRIV---SGGTDNHLFLVDLSSSDLTGAD-AEKLLESVNITLNKNAIPFDK- 355
Query: 356 EKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKED--PKKVRKDVYYF 408
+ + SG+RIG +T G+ E + +A F+ R L K D K+++K+V F
Sbjct: 356 KSPSLASGIRIGGAAITSRGLNESDSLNVAKFIVRALKAKSDIELKQIKKEVVRF 410
>sp|Q9XAZ1|GLYA_NEIMC SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|5051456|emb|CAB44976.1| (AJ242842) putative serine
hydroxymethyltransferase [Neisseria meningitidis]
Length = 416
Score = 231 bits (583), Expect = 1e-59
Identities = 145/395 (36%), Positives = 225/395 (56%), Gaps = 15/395 (3%)
Query: 15 EEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGV 74
+E ++ + H + LIASEN S +V A S +KYAEG+P +RYY GC+YVD VE + +
Sbjct: 21 QEDQRQQDH-VELIASENYVSCAVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI 79
Query: 75 ELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRG 134
+ KLF + YA+++P SG+ ANQAV+ + +PGD ++ + +HGGH++H +
Sbjct: 80 DRVKKLFGAQYANVQPHSGSQANQAVYASVLKPGDTILGMSLAHGGHLTHGASVNISGKL 139
Query: 135 LEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVV 194
T+ D E+ +D + E++ E +PK++V G S + + +A +VGA++
Sbjct: 140 YNAVTYGLD-ENEVLDYAEVERLALEHKPKMIVAGASAYALQIDWAKFREIADKVGAYLF 198
Query: 195 YDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAI 254
D AH GLIAGGE+ +P+ D +T +THKT GP+GGVIL + D+ L +I
Sbjct: 199 VDMAHYAGLIAGGEYPNPV-PFCDFVTTTTHKTLRGPRGGVILCR---DNTHEKALNSSI 254
Query: 255 FPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGY 313
FP + +H +A K + E L+ + YAKQ+ NA A+AE L + G +++ G
Sbjct: 255 FPSLQGGPLMHVIAAKAVAFKEALQPEFKQYAKQVKINAAAMAEELVKRGLRIV---SGR 311
Query: 314 TKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTR 373
T+SH +VD+ + G A L +A I +NKN +P DP EK SG+RIG MT
Sbjct: 312 TESHVFLVDLQPMKITGKA-AEAALGKAHITVNKNAIPNDP-EKPFVTSGIRIGSAAMTT 369
Query: 374 VGMMEDEMKEIAHFMKRVLLDKEDP---KKVRKDV 405
G E + + +A+ + VL + ED + VRK +
Sbjct: 370 RGFNEADARVLANLVADVLSNPEDEANLENVRKQI 404
>sp|Q9XAY7|GLYA_NEIMA SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|11256997|pir||E81893 glycine
hydroxymethyltransferase (EC 2.1.2.1) NMA1254 [imported]
- Neisseria meningitidis (group A strain Z2491)
>gi|5051446|emb|CAB44965.1| (AJ242841) putative serine
hydroxymethyltransferase [Neisseria meningitidis]
>gi|7379935|emb|CAB84509.1| (AL162755) putative serine
hydroxymethyltransferase [Neisseria meningitidis Z2491]
Length = 416
Score = 231 bits (582), Expect = 2e-59
Identities = 142/390 (36%), Positives = 222/390 (56%), Gaps = 12/390 (3%)
Query: 15 EEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGV 74
+E ++ + H + LIASEN S +V A S +KYAEG+P +RYY GC+YVD VE + +
Sbjct: 21 QEDQRQQDH-VELIASENYVSCAVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI 79
Query: 75 ELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRG 134
+ KLF + YA+++P SG+ ANQAV+ + +PGD ++ + +HGGH++H +
Sbjct: 80 DRVKKLFGAQYANVQPHSGSQANQAVYASVLKPGDTILGMSLAHGGHLTHGASVNISGKL 139
Query: 135 LEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVV 194
T+ D E+ +D + E++ E +PK++V G S + + +A +VGA++
Sbjct: 140 YNAVTYGLD-ENEVLDYAEVERLALEHKPKMIVAGASAYALQIDWAKFREIADKVGAYLF 198
Query: 195 YDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAI 254
D AH GL+AGGE+ +P+ D +T +THKT GP+GGVIL + D+ L +I
Sbjct: 199 VDMAHYAGLVAGGEYPNPV-PFCDFVTTTTHKTLRGPRGGVILCR---DNTHEKALNSSI 254
Query: 255 FPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGY 313
FP + +H +A K + E L+ + YAKQ+ NA A+AE L + G +++ G
Sbjct: 255 FPSLQGGPLMHVIAAKAVAFKEALQPEFKQYAKQVKINAAAMAEELVKRGLRIV---SGR 311
Query: 314 TKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTR 373
T+SH +VD+ + G A L +A I +NKN +P DP EK SG+RIG MT
Sbjct: 312 TESHVFLVDLQPMKITGKA-AEAALGKAHITVNKNAIPNDP-EKPFVTSGIRIGSAAMTT 369
Query: 374 VGMMEDEMKEIAHFMKRVLLDKEDPKKVRK 403
G E + + +A+ + VL + ED + K
Sbjct: 370 RGFNEADARVLANLVADVLSNPEDEANLAK 399
>dbj|BAB07484.1| (AP001519) serine hydroxymethyltransferase [Bacillus halodurans]
Length = 413
Score = 230 bits (580), Expect = 3e-59
Identities = 136/397 (34%), Positives = 228/397 (57%), Gaps = 13/397 (3%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
KV +++ + I LIASEN S +V A +S +KYAEG+P +RYY GC+YVD
Sbjct: 10 KVFEAVQQELGRQRDKIELIASENFVSEAVMEAQSSVLTNKYAEGYPGRRYYGGCEYVDI 69
Query: 69 VELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MPF 127
VE + + ++F ++ +++P SG AN AV+F + + GD V+ ++ SHGGH++H P
Sbjct: 70 VEDLARDRAKEIFGGEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLSHGGHLTHGSPV 129
Query: 128 GAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAK 187
+G++ V + D ES ID ++ ++ +E +PK++V G S +P + +A
Sbjct: 130 NFSGIQYNFVE-YGVDKESQRIDYEEVRRLAKEHQPKMIVAGASAYPREIDFAKFREIAD 188
Query: 188 EVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETI 247
EVGA+++ D AH+ GL+A G Q+P+ + +T +THKT GP+GG+I+ ++E
Sbjct: 189 EVGAYLMVDMAHIAGLVAAGLHQNPVPH-SHFVTTTTHKTLRGPRGGMII----CNEEFA 243
Query: 248 AKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGFKV 306
++ +IFPG+ +H +A K + E L+ ++Y + I++NAK L E L EG +
Sbjct: 244 KQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQPEFKSYGEAIIRNAKRLGEKLTSEGIDL 303
Query: 307 IGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRI 366
+ G T +H +++D+ L G A L++ GI NKN +P+DP E SG+RI
Sbjct: 304 V---SGGTDNHLLLLDLRSL-GLTGKVAEKALDDVGITTNKNTIPFDP-ESPFVTSGIRI 358
Query: 367 GVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRK 403
G +T G+ E+ M EI + L + ++ +K+ +
Sbjct: 359 GTAAVTSRGLDEEAMDEIGATIALTLKNVDNEEKMNE 395
>sp|P56990|GLYA_NEIMB SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|11257000|pir||B81126 serine hydroxymethyltransferase
NMB1055 [imported] - Neisseria meningitidis (group B
strain MD58) >gi|7226295|gb|AAF41452.1| (AE002456)
serine hydroxymethyltransferase [Neisseria meningitidis
MC58]
Length = 416
Score = 229 bits (578), Expect = 5e-59
Identities = 145/395 (36%), Positives = 225/395 (56%), Gaps = 15/395 (3%)
Query: 15 EEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGV 74
+E ++ + H + LIASEN S +V A S +KYAEG+P +RYY GC+YVD VE + +
Sbjct: 21 QEDQRQQDH-VELIASENYVSCAVMDAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI 79
Query: 75 ELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRG 134
+ +LF + YA+++P SG+ ANQAV+ + +PGD ++ + +HGGH++H +
Sbjct: 80 DRVKELFGAAYANVQPHSGSQANQAVYASVLKPGDTILGMSLAHGGHLTHGASVNISGKL 139
Query: 135 LEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVV 194
T+ D E+ +D + E++ E +PK++V G S + + +A +VGA++
Sbjct: 140 YNAVTYGLD-ENEVLDYAEVERLALEHKPKMIVAGASAYALQIDWAKFREIADKVGAYLF 198
Query: 195 YDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAI 254
D AH GL+AGGE+ +P+ D +T +THKT GP+GGVIL + D+ L +I
Sbjct: 199 VDMAHYAGLVAGGEYPNPV-PFCDFVTTTTHKTLRGPRGGVILCR---DNTHEKALNSSI 254
Query: 255 FPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGY 313
FP + +H +A K + E L+ + YAKQ+ NA A+AE L + G +++ G
Sbjct: 255 FPSLQGGPLMHVIAAKAVAFKEALQPEFKQYAKQVKINAAAMAEELVKRGLRIV---SGR 311
Query: 314 TKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTR 373
T+SH +VD+ + G A L +A I +NKN +P DP EK SG+RIG MT
Sbjct: 312 TESHVFLVDLQPMKITGKA-AEAALGKAHITVNKNAIPNDP-EKPFVTSGIRIGSAAMTT 369
Query: 374 VGMMEDEMKEIAHFMKRVLLDKEDP---KKVRKDV 405
G E + + +A+ + VL + ED KVRK V
Sbjct: 370 RGFNEADARVLANLVADVLSNPEDEANLAKVRKQV 404
>sp|Q9XB01|GLYA_NEIGO SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|5051423|emb|CAB45001.1| (AJ242839) putative serine
hydroxymethyltransferase [Neisseria gonorrhoeae]
Length = 416
Score = 227 bits (572), Expect = 2e-58
Identities = 139/400 (34%), Positives = 223/400 (55%), Gaps = 11/400 (2%)
Query: 5 EYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCK 64
+Y + I + ++ + + LIASEN S +V A S +KYAEG+P +RYY GC+
Sbjct: 10 QYDPDLAAAIAQEDRRQQDHVELIASENYVSCAVMEAQGSQLTNKYAEGYPAKRYYGGCE 69
Query: 65 YVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
YVD VE + ++ +LF + YA+++P SG+ ANQAV+ + +PGD ++ + +HGGH++H
Sbjct: 70 YVDIVEQLAIDRVKELFGAAYANVQPHSGSQANQAVYASVLKPGDTILGMSLAHGGHLTH 129
Query: 125 MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAP 184
+ T+ D E+ +D + E++ E +PK++V G S + +
Sbjct: 130 GASVNISGKLYNAVTYGLD-ENEVLDYAEVERLALEHKPKMIVAGASAYALQIDWAKFRE 188
Query: 185 VAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADD 244
+A +VGA++ D AH GL+AGGE+ +P+ D +T +THKT GP+GGVIL + D+
Sbjct: 189 IADKVGAYLFVDMAHYAGLVAGGEYPNPV-PFCDFVTTTTHKTLRGPRGGVILCR---DN 244
Query: 245 ETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEG 303
L +IFP + +H +A K + E L+ + YAKQ+ NA +AE L + G
Sbjct: 245 THEKALNSSIFPSLQGGPLMHVIAAKAVAFKEALQPEFKQYAKQVKINAAVMAEELVKRG 304
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSG 363
+++ G T+SH +VD+ + G A L +A I +NKN +P DP EK SG
Sbjct: 305 LRIV---SGRTESHVFLVDLQPMKITGKA-AEAALGKAHITVNKNAIPNDP-EKPFVTSG 359
Query: 364 LRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRK 403
+RIG MT G E + + +++ + VL + ED + K
Sbjct: 360 IRIGSAAMTTRGFNETDARVLSNLVADVLANPEDEANLAK 399
>emb|CAB44942.1| (AJ242840) putative serine hydroxymethyltransferase [Neisseria
gonorrhoeae]
Length = 416
Score = 227 bits (572), Expect = 2e-58
Identities = 139/400 (34%), Positives = 223/400 (55%), Gaps = 11/400 (2%)
Query: 5 EYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCK 64
+Y + I + ++ + + LIASEN S +V A S +KYAEG+P +RYY GC+
Sbjct: 10 QYDPDLAAAIAQEDRRQQDHVELIASENYVSCAVMEAQGSQLTNKYAEGYPAKRYYGGCE 69
Query: 65 YVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
YVD VE + ++ +LF + YA+++P SG+ ANQAV+ + +PGD ++ + +HGGH++H
Sbjct: 70 YVDIVEQLAIDRVKELFGAAYANVQPHSGSQANQAVYASVLKPGDTILGMSLAHGGHLTH 129
Query: 125 MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAP 184
+ T+ D E+ +D + E++ E +PK++V G S + +
Sbjct: 130 GASVNISGKLYNAVTYGLD-ENEVLDYAEVERLALEHKPKMIVAGASAYALQIDWAKFRE 188
Query: 185 VAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADD 244
+A +VGA++ D AH GL+AGGE+ +P+ D +T +THKT GP+GGVIL + D+
Sbjct: 189 IADKVGAYLFVDMAHYAGLVAGGEYPNPV-PFCDFVTTTTHKTLRGPRGGVILCR---DN 244
Query: 245 ETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEG 303
L +IFP + +H +A K + E L+ + YAKQ+ NA +AE L + G
Sbjct: 245 THEKALNSSIFPSLQGGPLMHVIAAKAVAFKEALQPEFKQYAKQVKINAAVMAEELVKRG 304
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSG 363
+++ G T+SH +VD+ + G A L +A I +NKN +P DP EK SG
Sbjct: 305 LRIV---SGRTESHVFLVDLQPMKITGKA-AEAALGKAHITVNKNAIPNDP-EKPFVTSG 359
Query: 364 LRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRK 403
+RIG MT G E + + +++ + VL + ED + K
Sbjct: 360 IRIGSAAMTTRGFNETDARVLSNLVADVLANPEDEANLAK 399
>pir||E82743 serine hydroxymethyltransferase XF0946 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9105871|gb|AAF83756.1|AE003933_8 (AE003933) serine
hydroxymethyltransferase [Xylella fastidiosa]
Length = 424
Score = 222 bits (560), Expect = 6e-57
Identities = 138/371 (37%), Positives = 211/371 (56%), Gaps = 13/371 (3%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN S V + S +KYAEG+ +RYY GC+ VD E + +E +LF +D
Sbjct: 37 VELIASENYCSTLVMQVQGSQLTNKYAEGYSGKRYYGGCECVDIAEQLAIERAKQLFGAD 96
Query: 85 YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGA-AGMRGLEVHTWPFD 143
YA+++P SG+ ANQAV+F L QPGD ++ + +HGGH++H GA + G + +
Sbjct: 97 YANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTH---GANVNVSGKLFNAVQYG 153
Query: 144 -NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLG 202
N ID + E + E PK+VV G S + +A +VGA+++ D AHV G
Sbjct: 154 VNGQGLIDYEAVESLALEHRPKMVVAGFSAYSQKIDWARFRAIADQVGAYLLVDMAHVAG 213
Query: 203 LIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNH 262
L+A + +PL A ++T++THKT GP+GG+I+ + + + KLQ +FPG+
Sbjct: 214 LVAACVYPNPLPH-AHVVTSTTHKTLRGPRGGIIV-AQAPQEALVKKLQSIVFPGIQGGP 271
Query: 263 HLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIV 321
+H +A K + E LE + Y +Q+VKNAKA+AE L G+K++ G T++H ++V
Sbjct: 272 LMHVIAAKAVAFKEALEPAFKVYQQQVVKNAKAMAETLMLRGYKIV---SGGTENHLMLV 328
Query: 322 DVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEM 381
D+ G A L +A I +NKN +P DP SGLR+G +T G E +
Sbjct: 329 DMIG-RDVSGKDAEGALGQAHITVNKNAVPDDPRSPF-VTSGLRLGTPAVTTRGYQEQDC 386
Query: 382 KEIAHFMKRVL 392
++AH++ VL
Sbjct: 387 VDLAHWIADVL 397
>pir||A82480 serine hydroxymethyltransferase VCA0278 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9657675|gb|AAF96188.1| (AE004367) serine
hydroxymethyltransferase [Vibrio cholerae]
Length = 435
Score = 222 bits (559), Expect = 8e-57
Identities = 140/389 (35%), Positives = 204/389 (51%), Gaps = 16/389 (4%)
Query: 8 DKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVD 67
D V I+ ++ I LIASENI S +V +A + +KYAEG+P +RYY GC++VD
Sbjct: 27 DAVFAAIQAEYTRQNEQIELIASENIVSKAVMQAQGTCLTNKYAEGYPGRRYYGGCEHVD 86
Query: 68 EVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPF 127
VE I +E LF+ YA+++P SG AN AV L QPGD ++ + GGH++H
Sbjct: 87 SVEQIAIERAKMLFQCQYANVQPHSGAQANGAVMLALLQPGDTIMGMSLDAGGHLTHGAR 146
Query: 128 GAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAK 187
A + + D ++ I+ D + E +PK+++ GGS P + +
Sbjct: 147 PALSGKWFNAVQYGVDRQTLEINYDSVRALALEHKPKMIIAGGSAIPRTIDFAQFRSIVD 206
Query: 188 EVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETI 247
EVGA ++ D AH+ GL+A G PL A ++T +THKT GP+GG+IL +E
Sbjct: 207 EVGALLMVDMAHIAGLVATGAHPSPLPH-AHVVTTTTHKTLRGPRGGMILTN---SEEIH 262
Query: 248 AKLQWAIFPGVLSNHHLHHMAGKVITAAEML--EYGEAYAKQIVKNAKALAEALAEEGFK 305
K+ A+FPG+ +H +A K + E L E+ Y ++ NAK LAE L G
Sbjct: 263 KKINSAVFPGLQGGPLMHVIAAKAVAFGEALGPEF-RTYIDSVIDNAKVLAEVLQTRGCD 321
Query: 306 VIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSG 363
++ G T +H ++V DL P G G LE AGI NKN +P+D EK SG
Sbjct: 322 IV---TGGTDTHLMLV---DLRPKGLKGNQVEQALERAGITCNKNGIPFDE-EKPMITSG 374
Query: 364 LRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
+R+G T G +E K I ++ VL
Sbjct: 375 IRLGTPAGTSRGFGREEFKLIGEWIGDVL 403
>sp|P43844|GLYA_HAEIN SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|1075298|pir||D64100 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Haemophilus influenzae (strain Rd KW20)
>gi|1573908|gb|AAC22549.1| (U32771) serine
hydroxymethyltransferase (serine methylase) (glyA)
[Haemophilus influenzae Rd]
Length = 421
Score = 220 bits (555), Expect = 2e-56
Identities = 145/416 (34%), Positives = 223/416 (52%), Gaps = 35/416 (8%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
M +Y + I++ + + I LIASEN SP V A S F +KYAEG+P +RYY
Sbjct: 6 MTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYY 65
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
GC+Y D VE + ++ +LF +DY +++P SG+ AN AV+ L GD ++ + +HGG
Sbjct: 66 GGCEYADIVEQLAIDRAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGG 125
Query: 121 HISHMPFGAAGMRGLEVHTWPFDNESFN-----------IDVDKAEKMIRELEPKIVVFG 169
H++H G +V F + +N ID + + E +PK++V G
Sbjct: 126 HLTH---------GAKV---SFSGKIYNSVLYGITADGLIDYEDVRQKALECKPKLIVAG 173
Query: 170 GSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFP 229
S + ++ +A EVGA++ D AHV GLIA G + +PL A ++T +THKT
Sbjct: 174 FSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPH-AHVVTTTTHKTLG 232
Query: 230 GPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE--YGEAYAKQ 287
GP+GG+IL D+E KLQ ++FP +H +A K + LE Y E Y
Sbjct: 233 GPRGGLIL-SSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKGALEPQYKE-YQAN 290
Query: 288 IVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNK 347
++KNAKA+ E + G+ V+ T++H +V G A L +A I +NK
Sbjct: 291 VIKNAKAMVEVFKQRGYDVVSNG---TENHLFLVSFIKQGLTGKA-ADAALGKANITVNK 346
Query: 348 NLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL--LDKEDPKKV 401
N +P DP +K SG+R+G +TR G E++++E+A +M VL L KE+ ++V
Sbjct: 347 NAVPNDP-QKPFVTSGIRVGTPSVTRRGFNENDVRELAGWMCDVLDALGKENEEQV 401
>pir||D83070 serine hydroxymethyltransferase PA4602 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9950852|gb|AAG07990.1|AE004874_3 (AE004874) serine
hydroxymethyltransferase [Pseudomonas aeruginosa]
Length = 417
Score = 220 bits (554), Expect = 3e-56
Identities = 137/397 (34%), Positives = 220/397 (54%), Gaps = 10/397 (2%)
Query: 6 YRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKY 65
Y ++ +E+ + + I LIASEN TSP+V A S +KYAEG+P +RYY GC+Y
Sbjct: 11 YDAELFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPHKRYYGGCEY 70
Query: 66 VDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHM 125
VD VE + ++ +LF +DYA+++P +G+ AN AV+ L GD ++ + +HGGH++H
Sbjct: 71 VDIVEQLAIDRAKQLFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHG 130
Query: 126 PFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPV 185
++ + + D ID D+ E++ E +PK++V G S + +
Sbjct: 131 ASVSSSGKLYNAVQYGIDANGL-IDYDEVERLAVEHKPKMIVAGFSAYSQVLDFARFRAI 189
Query: 186 AKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDE 245
A +VGA++ D AHV GL+A G + +P+ AD++T +THKT GP+GG+IL + A++E
Sbjct: 190 ADKVGAYLFVDMAHVAGLVAAGVYPNPV-PFADVVTTTTHKTLRGPRGGLILAR--ANEE 246
Query: 246 TIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGF 304
KL A+FP H +A K + E L+ + Y +Q++KNA+++A+ + GF
Sbjct: 247 IEKKLNSAVFPSAQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVLKNAQSMAQVFLDRGF 306
Query: 305 KVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGL 364
V+ G T++H ++ + G A L A I +NKN +P DP SGL
Sbjct: 307 DVV---SGGTQNHLFLLSLIKQDITGKD-ADAALGRAFITVNKNSVPNDPRSPF-VTSGL 361
Query: 365 RIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKV 401
RIG +T G E E +E+A ++ +L + D V
Sbjct: 362 RIGTPAVTTRGFKEAECRELAGWICDILENMGDESVV 398
>pir||JQ1016 glycine hydroxymethyltransferase (EC 2.1.2.1) - Campylobacter
jejuni >gi|40534|emb|CAA37812.1| (X53816) glyA protein
(AA 1 - 414) [Campylobacter jejuni]
Length = 414
Score = 219 bits (553), Expect = 4e-56
Identities = 128/376 (34%), Positives = 211/376 (56%), Gaps = 11/376 (2%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ +IASEN T P V + S +KYAEG+P +RYY GC++VDE+E + +E KLF
Sbjct: 25 LEMIASENFTLPEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIETLAIERCKKLFNCK 84
Query: 85 YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDN 144
+A+++P SG+ ANQ V+ L PGDK++ + SHGGH++H ++ + E + +
Sbjct: 85 FANVQPNSGSQANQGVYAALINPGDKILGMDLSHGGHLTHGAKVSSSGKMYESCFYGVEL 144
Query: 145 ESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLI 204
+ ID +K ++ ++ +PK++V G S + + +A EVGA++ D AH+ GL+
Sbjct: 145 DG-RIDYEKVREIAKKEKPKLIVCGASAYARVIDFAKFREIADEVGAYLFADIAHIAGLV 203
Query: 205 AGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHL 264
GE P A +++++THKT GP+GG+I+ D+E K+ AIFPG+ +
Sbjct: 204 VAGEHPSPFPH-AHVVSSTTHKTLRGPRGGIIMTN---DEELAKKINSAIFPGIQGGPLM 259
Query: 265 HHMAGKVI-TAAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDV 323
H +A K + + + + YAKQ+ NA+ LA L + FK++ + T +H V++
Sbjct: 260 HVIAAKAVGFKFNLSDEWKVYAKQVRTNAQVLANVLMDRKFKLVSDG---TDNHLVLMSF 316
Query: 324 SDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKE 383
D +G A L AGI NKN +P + + SGLR+G +T G E EM+
Sbjct: 317 LDREFSGKD-ADLALGNAGITANKNTVPGE-IRSPFITSGLRLGTPALTARGFKEKEMEI 374
Query: 384 IAHFMKRVLLDKEDPK 399
+++++ +L D + K
Sbjct: 375 VSNYIADILDDINNEK 390
>sp|P50435|GLYA_METEX SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|496116|gb|AAA64456.1| (L33463) serine
hydroxymethyltransferase [Methylobacterium extorquens]
Length = 434
Score = 219 bits (552), Expect = 5e-56
Identities = 134/374 (35%), Positives = 204/374 (53%), Gaps = 12/374 (3%)
Query: 21 RSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKL 80
+ H I LIASENI S +V A S +KYAEG+P +RYY GC++VD E + ++ +L
Sbjct: 38 QQHEIELIASENIVSRAVLEAQGSVLTNKYAEGYPGRRYYGGCQFVDIAEELAIDRAKRL 97
Query: 81 FKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTW 140
F +A+++P SG+ ANQ VF L QPGD + L + GGH++H + + ++
Sbjct: 98 FGCGFANVQPNSGSQANQGVFMALMQPGDTFLGLDLAAGGHLTHGAPPNVSGKWFKPVSY 157
Query: 141 PFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHV 200
E ID+++ E++ +E +PK+++ GGS +P + +A VGA+ D AH
Sbjct: 158 TVRREDQRIDMEQVERLAQEHKPKVIIAGGSGYPRHWDFAKFREIADSVGAYFFVDMAHF 217
Query: 201 LGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIA-KLQWAIFPGVL 259
GL+A G P A + T +THKT GP+GG+IL +DE +A K AIFPG+
Sbjct: 218 AGLVAAGLHPSPFPH-AHVATTTTHKTLRGPRGGMIL----TNDEALAKKFNSAIFPGLQ 272
Query: 260 SNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQ 318
+H +A K E L+ + YAKQ++ NA+ALA+ + G+ + G T +H
Sbjct: 273 GGPLMHVIAAKAAAFGEALKPEFKIYAKQVIDNARALADTIISGGYDI---TSGGTDNHL 329
Query: 319 VIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMME 378
++VD+ G A L A I NKN +P+DP +K SG+R+G T G
Sbjct: 330 MLVDLQKKGLTGKA-AEAALSRADITCNKNGVPFDP-QKPTITSGIRLGTPASTTRGFGV 387
Query: 379 DEMKEIAHFMKRVL 392
E K++ + +VL
Sbjct: 388 AEFKQVGSLIVQVL 401
>sp|P24531|GLYA_CAMJE SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|11256999|pir||H81383 glycine
hydroxymethyltransferase (EC 2.1.2.1) Cj0402 [imported]
- Campylobacter jejuni (strain NCTC 11168)
>gi|6967876|emb|CAB74238.1| (AL139075) serine
hydroxymethyltransferase [Campylobacter jejuni]
Length = 414
Score = 219 bits (551), Expect = 7e-56
Identities = 127/376 (33%), Positives = 211/376 (55%), Gaps = 11/376 (2%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ +IASEN T P V + S +KYAEG+P +RYY GC++VDE+E + +E KLF
Sbjct: 25 LEMIASENFTLPEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIETLAIERCKKLFNCK 84
Query: 85 YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDN 144
+A+++P SG+ ANQ V+ L PGDK++ + SHGGH++H ++ + E + +
Sbjct: 85 FANVQPNSGSQANQGVYAALINPGDKILGMDLSHGGHLTHGAKVSSSGKMYESCFYGVEL 144
Query: 145 ESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLI 204
+ ID +K ++ ++ +PK++V G S + + +A E+GA++ D AH+ GL+
Sbjct: 145 DG-RIDYEKVREIAKKEKPKLIVCGASAYARVIDFAKFREIADEIGAYLFADIAHIAGLV 203
Query: 205 AGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHL 264
GE P A +++++THKT GP+GG+I+ D+E K+ AIFPG+ +
Sbjct: 204 VAGEHPSPF-PYAHVVSSTTHKTLRGPRGGIIMTN---DEELAKKINSAIFPGIQGGPLM 259
Query: 265 HHMAGKVI-TAAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDV 323
H +A K + + + + YAKQ+ NA+ LA L + FK++ + T +H V++
Sbjct: 260 HVIAAKAVGFKFNLSDEWKVYAKQVRTNAQVLANVLMDRKFKLVSDG---TDNHLVLMSF 316
Query: 324 SDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKE 383
D +G A L AGI NKN +P + + SGLR+G +T G E EM+
Sbjct: 317 LDREFSGKD-ADLALGNAGITANKNTVPGE-IRSPFITSGLRLGTPALTARGFKEKEMEI 374
Query: 384 IAHFMKRVLLDKEDPK 399
+++++ +L D + K
Sbjct: 375 VSNYIADILDDVNNEK 390
>sp|P56089|GLYA_HELPY SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433535|pir||G64542 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Helicobacter pylori (strain 26695)
>gi|2313271|gb|AAD07252.1| (AE000538) serine
hydroxymethyltransferase (glyA) [Helicobacter pylori
26695]
Length = 416
Score = 213 bits (538), Expect = 2e-54
Identities = 140/399 (35%), Positives = 222/399 (55%), Gaps = 17/399 (4%)
Query: 1 MAY--KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQR 58
MAY ++ ++ I E K ++ + +IASEN T SV A+ S +KYAEG+P +R
Sbjct: 1 MAYFLEQTDSEIFELIFEEYKRQNEHLEMIASENYTFASVMEAMGSVLTNKYAEGYPNKR 60
Query: 59 YYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSH 118
YY GC+ VD++E + +E KLF +A+++ SG+ AN AV+ L +P DK++ + S
Sbjct: 61 YYGGCEVVDKIESLAIERAKKLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSC 120
Query: 119 GGHISHMPFGA-AGMRGLEVHTWPFD-NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFP 176
GGH++H GA + G ++ + N ID ++A K+ + ++P+I+V G S +P
Sbjct: 121 GGHLTH---GAKVSLTGKHYQSFSYGVNLDGYIDYEEALKIAQSVKPEIIVCGFSAYPRE 177
Query: 177 HPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVI 236
K+ +A EVGA ++ D AHV GL+ GE P +++++THKT GP+GG+I
Sbjct: 178 IDFKKFREIADEVGALLLGDIAHVAGLVVTGEHAHPFPH-CHVVSSTTHKTLRGPRGGII 236
Query: 237 LYKKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKAL 295
L D+E AK+ AIFPG +H +A K + E L+ +AYA+ + N + L
Sbjct: 237 LTN---DEEIAAKIDKAIFPGTQGGPLMHVIAAKAVGFKENLKPEFKAYAQLVKSNMQVL 293
Query: 296 AEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPL 355
A+AL E+ K++ G T +H +++D D P G A L AGI +NKN +P +
Sbjct: 294 AKALKEKNHKLV---SGGTSNHLLLMDFLD-KPYSGKDADIALGNAGITVNKNTIPGETR 349
Query: 356 EKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLD 394
SG+RIG ++ GM E + I + + +L D
Sbjct: 350 SPF-VTSGIRIGSAALSARGMGAKEFEIIGNKISDILND 387
>sp|P78011|GLYA_MYCPN SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|2146647|pir||S73592 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Mycoplasma pneumoniae (strain ATCC 29342)
>gi|1673936|gb|AAB95914.1| (AE000026) serine
hydroxymethyltransferase [Mycoplasma pneumoniae]
Length = 406
Score = 210 bits (529), Expect = 3e-53
Identities = 128/399 (32%), Positives = 223/399 (55%), Gaps = 17/399 (4%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
K+ + + + + I LIASEN S + S +KYAEG+P +R+Y+GC+ VDE
Sbjct: 4 KIRRILNKELQRQRDCICLIASENYVSRDILEVTGSILTNKYAEGYPTRRFYEGCEVVDE 63
Query: 69 VELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MPF 127
E + + +LF + +A+++P SG++AN AV+ L +PGD ++ L + GGH++H F
Sbjct: 64 SESLAINTCKELFGAKWANVQPHSGSSANYAVYLALLKPGDAILGLDLNCGGHLTHGNKF 123
Query: 128 GAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAK 187
+G + + +++ + E+ +D D+ ++ RE++PK+++ G S + + + +AK
Sbjct: 124 NFSG-KQYQPYSYTINPETEMLDYDEVLRVAREVKPKLIICGFSNYSRTVDFERFSAIAK 182
Query: 188 EVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETI 247
EVGA+++ D AH+ GL+A G +PL D++T++THKT GP+GG+I+ ++ I
Sbjct: 183 EVGAYLLADIAHIAGLVAAGLHPNPL-PYTDVVTSTTHKTLRGPRGGLIMSN---NEAII 238
Query: 248 AKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGFKV 306
KL +FPG H +A K + E L+ + Y + + NA ++A ++G++V
Sbjct: 239 RKLDSGVFPGCQGGPLQHVIAAKYVCFKEALQPKYKQYIQNVKTNAASMASWFKQQGYRV 298
Query: 307 IGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRI 366
I T +H +DV G + L++A I+LN N +P+D +N PSG+RI
Sbjct: 299 ISNG---TDTHLFSLDVGK-----GKDVSQWLQQANIVLNMNTVPFDKNPAIN-PSGIRI 349
Query: 367 GVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDV 405
G MT G E +A + ++ + + KKV K+V
Sbjct: 350 GTPAMTTRGFKEKHFLYVAALIDKI-IKSDGNKKVIKEV 387
>sp|Q9ZMP7|GLYA_HELPJ SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433552|pir||G71965 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Helicobacter pylori (strain J99)
>gi|4154686|gb|AAD05752.1| (AE001455) SERINE
HYDROXYMETHYLTRANSFERASE [Helicobacter pylori J99]
Length = 416
Score = 208 bits (524), Expect = 1e-52
Identities = 135/397 (34%), Positives = 219/397 (55%), Gaps = 13/397 (3%)
Query: 1 MAY--KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQR 58
MAY ++ ++ FI E K ++ + +IASEN T PSV A+ S +KYAEG+P +R
Sbjct: 1 MAYFLEQTDSEIFEFIVEEFKRQNEHLEMIASENYTFPSVMEAMGSILTNKYAEGYPNKR 60
Query: 59 YYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSH 118
YY GC+ VD++E + +E KLF +A+++ SG+ AN AV+ L + DK++ + S
Sbjct: 61 YYGGCEVVDKIESLAIERAKKLFNCQFANVQAHSGSQANNAVYHALLKLYDKILGMDLSC 120
Query: 119 GGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHP 178
GGH++H + + + ++ + + ID ++A K+ + ++P+I+V G S +P
Sbjct: 121 GGHLTHGAKVSLTGKHYQSFSYGVGLDGY-IDYEEALKIAQSVKPQIIVCGFSAYPREID 179
Query: 179 VKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILY 238
K+ +A VGA ++ D AHV GL+ E P +++++THKT GP+GG+IL
Sbjct: 180 FKKFREIADAVGALLLGDIAHVAGLVVANEHAHPFPH-CHVVSSTTHKTLRGPRGGLILT 238
Query: 239 KKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAE 297
D+E AK+ AIFPG +H +A K + E L+ +AYAK + N + LA+
Sbjct: 239 N---DEEIAAKIDKAIFPGTQGGPLMHVIAAKAVGFKENLKPEFKAYAKLVKSNMQVLAK 295
Query: 298 ALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEK 357
L E+ K++ G T +H +++D D P G A L AGI +NKN +P +
Sbjct: 296 TLKEKNHKLV---SGGTSNHLLLMDFLD-KPYSGKDADIALGNAGITVNKNTIPGETRNP 351
Query: 358 VNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLD 394
SG+RIG ++ GM E + I + + +L D
Sbjct: 352 F-VTSGIRIGSAALSARGMGAKEFEIIGNKISDILND 387
>emb|CAC11940.1| (AL445065) glycine hydroxymethyltransferase related protein
[Thermoplasma acidophilum]
Length = 387
Score = 208 bits (524), Expect = 1e-52
Identities = 139/406 (34%), Positives = 219/406 (53%), Gaps = 28/406 (6%)
Query: 10 VLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEV 69
VL +++ + +RS+ +NL ASEN+ SP+V +A+ S F +Y+ Y G +Y +E+
Sbjct: 4 VLDIVQDADVYRSNVLNLQASENVISPNVRKALGSDFASRYSHMENGVNDYGGTRYAEEL 63
Query: 70 ELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGA 129
E E KLF YA+ R +SG A V L + G+ +I + S GG+ +
Sbjct: 64 ENTVSENAKKLFGFAYAETRMLSGHIAAMTVLAALVKRGESIIKVPESVGGYTGYSGAYL 123
Query: 130 AGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEV 189
M G + P + F ID D EK + ++PK++V G S+F + +K + +
Sbjct: 124 PRMMGFRSYDMPVGADGF-IDYDALEKHVEYVKPKMIVLGQSIFVKSYDMKRIREICDRH 182
Query: 190 GAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETI-A 248
+ YDA+HV+GLIAG +FQ ++E AD++ STHKTF GPQGG+IL D E I A
Sbjct: 183 SCLLGYDASHVMGLIAGKQFQKDIKE-ADVVFGSTHKTFFGPQGGIIL----TDSEKIFA 237
Query: 249 KLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIG 308
+++ +I + N+++ MAG + EM+ YGE YAK +++NAKALAEA+ +G I
Sbjct: 238 RIEDSITWRTMDNYNIARMAGVGVAIEEMIRYGEEYAKNVIRNAKALAEAM--DGRIKIR 295
Query: 309 EDQGYTKSHQVIVDVSDLHPAGGGWA--APLLEEAGIILNKNLLPWDPLEKVNEPSGLRI 366
YT+SHQ++VD + G + + ++EE GII+++ RI
Sbjct: 296 YAPWYTESHQILVDGDWIRSKGYDYVRFSRVMEENGIIVDRI---------------GRI 340
Query: 367 GVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEY 412
G E+TR+G+ D ++EIA M + +V K V ++ Y
Sbjct: 341 GTAEITRMGI--DNVEEIASMMVDAFNGIDVKDRVNKFVRNMKMRY 384
>emb|CAB94535.1| (AL359152) serine hydroxymethyltransferase [Streptomyces coelicolor
A3(2)]
Length = 418
Score = 207 bits (522), Expect = 2e-52
Identities = 139/393 (35%), Positives = 203/393 (51%), Gaps = 16/393 (4%)
Query: 21 RSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKL 80
+S T+ LIA+EN TSP+V A+ S +KYAEG+P R++ GC+ VD E + + L
Sbjct: 36 QSTTLQLIAAENFTSPAVLAALGSPLANKYAEGYPGARHHGGCEIVDVAERLAAQRAQAL 95
Query: 81 FKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTW 140
F +++A+++ SG++A A + L +PGD V+ L +GGH++H R + +
Sbjct: 96 FGAEHANVQSHSGSSAVLAAYAALLRPGDTVLALGLPYGGHLTHGSPANFSGRWFDFVGY 155
Query: 141 PFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHV 200
D E+ ID D+ + R PK +V G +P +A EVGA+++ DAAH
Sbjct: 156 GVDAETGLIDHDQVRTLARARRPKAIVCGSIAYPRHLDYAAFRDIADEVGAYLIADAAHP 215
Query: 201 LGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLS 260
+GL+AGG P+ ADI+ A+THK GP+GG+IL E ++ A+FP
Sbjct: 216 IGLVAGGAAPSPV-PYADIVCATTHKVLRGPRGGMIL----CGSELAERVDRAVFPFTQG 270
Query: 261 NHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQV 319
+H +A K + E AYA Q+V NA+ALA LA EG V G T +H +
Sbjct: 271 GAQMHTIAAKAVAFGEAATPAFAAYAHQVVANARALAAHLAAEGLVV---TTGGTDTHLL 327
Query: 320 IVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMED 379
D + L G A LL AGI+L+ LP + GLR+G +T GM E
Sbjct: 328 TADPAPL-GVDGKTARGLLAAAGIVLDCCALPH------ADARGLRLGTAAVTTQGMGER 380
Query: 380 EMKEIAHFMKRVLLDKEDPKKVRKDVYYFRLEY 412
EM+ +A + VL DP R DV E+
Sbjct: 381 EMRAVATLVAGVLRGTTDPAAARADVRDLTAEF 413
>sp|O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7481761|pir||T34750 serine hydroxymethyltransferase
- Streptomyces coelicolor >gi|3402237|emb|CAA20173.1|
(AL031184) serine hydroxymethyltransferase [Streptomyces
coelicolor A3(2)]
Length = 420
Score = 203 bits (512), Expect = 3e-51
Identities = 133/391 (34%), Positives = 206/391 (52%), Gaps = 23/391 (5%)
Query: 24 TINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKS 83
T+ +IASEN +V A S +KYAEG+P +RYY GC++VD VE I ++ LF +
Sbjct: 29 TLEMIASENFAPVAVMEAQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRVKALFGA 88
Query: 84 DYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMR----GLEVHT 139
++A+++P SG AN A F L +PGD ++ L+ +HGGH++H GM+ G +
Sbjct: 89 EHANVQPHSGAQANAAAMFALLKPGDTIMGLNLAHGGHLTH------GMKINFSGKLYNV 142
Query: 140 WPFD-NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAA 198
P+ + +D+ + E++ +E +PK++V G S +P VA EVGA+++ D A
Sbjct: 143 VPYHVGDDGQVDMAEVERLAKETKPKLIVAGWSAYPRQLDFAAFRKVADEVGAYLMVDMA 202
Query: 199 HVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGV 258
H GL+A G +P+ A ++T +THKT GP+GGVIL + E K+ A+FPG
Sbjct: 203 HFAGLVAAGLHPNPVPH-AHVVTTTTHKTLGGPRGGVIL----STAELAKKINSAVFPGQ 257
Query: 259 LSNHHLHHMAGKVIT--AAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGED--QGYT 314
H +A K + A ++ E + + + A+ LAE L + K G G T
Sbjct: 258 QGGPLEHVVAAKAVAFKVAASEDFKERQGRTL-EGARILAERLVRDDAKAAGVSVLTGGT 316
Query: 315 KSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRV 374
H V+VD+ D G A L E GI +N+N +P DP + SGLRIG +
Sbjct: 317 DVHLVLVDLRD-SELDGQQAEDRLHEVGITVNRNAVPNDPRPPM-VTSGLRIGTPALATR 374
Query: 375 GMMEDEMKEIAHFMKRVLLDKEDPKKVRKDV 405
G ++ E+A + L D + ++ V
Sbjct: 375 GFTAEDFAEVADVIAEALKPSYDAEALKARV 405
>pir||T05362 glycine hydroxymethyltransferase (EC 2.1.2.1) F8B4.220 -
Arabidopsis thaliana >gi|4049354|emb|CAA22579.1|
(AL034567) glycine hydroxymethyltransferase (EC
2.1.2.1)-like protein [Arabidopsis thaliana]
>gi|7270156|emb|CAB79969.1| (AL161581) glycine
hydroxymethyltransferase (EC 2.1.2.1)-like protein
[Arabidopsis thaliana]
Length = 462
Score = 203 bits (511), Expect = 3e-51
Identities = 137/391 (35%), Positives = 210/391 (53%), Gaps = 29/391 (7%)
Query: 15 EEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGV 74
E+ ++RS + LIASEN TS +V AV S +KY+EG P +RYY G +Y+D++E +
Sbjct: 30 EKDRQFRS--LELIASENFTSRAVMEAVGSCLTNKYSEGLPGKRYYGGNEYIDQLETLCQ 87
Query: 75 ELFTKLFKSDY----ADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAA 130
F+ D +++P+SG+ AN AV+ + P D+++ L HGGH+SH F A
Sbjct: 88 NRALAAFRLDSTKWGVNVQPLSGSPANFAVYTAILSPHDRIMGLDLPHGGHLSH-GFMTA 146
Query: 131 GMR--GLEVH----TWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAP 184
R G ++ + D + +D D EK PK+++ G S + +
Sbjct: 147 KRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTATLFRPKLIIAGASAYSRDFDYPRMRK 206
Query: 185 VAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK--FA 242
+A VGAF++ D AH+ GL+A DP E DI+T +THK+ GP+GG+I ++K
Sbjct: 207 IADSVGAFLMMDMAHISGLVAASVVADPF-EYCDIVTTTTHKSLRGPRGGMIFFRKDPIN 265
Query: 243 DDETIAKLQWAIFPGVLSNHHLHHMAGKVITA--AEMLEYGEAYAKQIVKNAKALAEALA 300
+ + + A+FPG+ H H + G + A+ E+ +AY K++V N +ALA L
Sbjct: 266 GVDLESAVNNAVFPGLQGGPHNHTIGGLAVCLKHAQSPEF-KAYQKRVVSNCRALANRLV 324
Query: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKV 358
E GFK++ G + +H V+V DL P G G +L+ A I LNKN +P D V
Sbjct: 325 ELGFKLV---SGGSDNHLVLV---DLRPMGMDGARVEKILDMASITLNKNSVPGDKSALV 378
Query: 359 NEPSGLRIGVQEMTRVGMMEDEMKEIAHFMK 389
P G+RIG MT G+ E + +A F+K
Sbjct: 379 --PGGIRIGSPAMTTRGLSEKDFVVVADFIK 407
>sp|P47634|GLYA_MYCGE SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|1361846|pir||F64243 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Mycoplasma genitalium
>gi|3844985|gb|AAC71622.1| (U39721) serine
hydroxymethyltransferase (glyA) [Mycoplasma genitalium]
Length = 406
Score = 202 bits (509), Expect = 6e-51
Identities = 127/395 (32%), Positives = 215/395 (54%), Gaps = 16/395 (4%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
KV + + + + I LIASEN S + S +KYAEG+P +R+YQGC+ VDE
Sbjct: 4 KVRLLLNKELQRQRENICLIASENYVSQDILAVTGSVLTNKYAEGYPSKRFYQGCEVVDE 63
Query: 69 VELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MPF 127
E + +E LF + +A+++P SG++AN AV+ L +PGD ++ L + GGH++H P
Sbjct: 64 SENLAIESCKTLFGAQWANVQPHSGSSANYAVYLALLKPGDTILGLDLNCGGHLTHGSPV 123
Query: 128 GAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAK 187
+G + + T+ D E+ +D D ++ E +PK+++ G S + K+ + +AK
Sbjct: 124 NFSG-KQYQAVTYSLDFETETLDYDAILQIALEHKPKLIICGFSNYSRTVDFKKFSAIAK 182
Query: 188 EVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETI 247
+V A+++ D AH+ G IA G Q+PL D++T++THKT GP+GG+I+ A I
Sbjct: 183 QVNAYLLADIAHIAGFIAAGLHQNPL-PFVDVVTSTTHKTLRGPRGGIIMSNNQA---II 238
Query: 248 AKLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAYAKQIVKNAKALAEALAEEGFKV 306
KL +FPG H +A K + E L + Y +Q+ NA A+A ++G++V
Sbjct: 239 KKLDSGVFPGCQGGPLQHVIAAKYVCFKEALNPKFKQYMQQVKDNALAMANWFLKQGYRV 298
Query: 307 IGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRI 366
+ + T++H + L G A L++A I+LN N +P++ + PSG+R+
Sbjct: 299 VSKG---TETH-----LFSLVVGNGKDVALWLQKANIVLNMNTIPFE-TKSAFSPSGIRL 349
Query: 367 GVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKV 401
G MT G ++ +A + +V+ + K +
Sbjct: 350 GTPAMTTRGFKTNDFIFVASLIDKVIKSNGNQKVI 384
>gb|AAF46101.1| (AE003435) CG3011 gene product [Drosophila melanogaster]
Length = 537
Score = 199 bits (501), Expect = 5e-50
Identities = 131/407 (32%), Positives = 220/407 (53%), Gaps = 33/407 (8%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
++ I++ ++ + + +IASEN TS +V +++S +KY+EG+P +RYY G +Y+D
Sbjct: 87 ELAELIKKEKERQREGLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYGGNEYIDR 146
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+EL+ + +LF D +++P SG+ AN AV+ G+ +P D+++ L GGH++H
Sbjct: 147 IELLAQQRGRELFNLDDEKWGVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHLTH 206
Query: 125 ---MPFGAAGMRGLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
P + + P+ + E+ ID DK + + P+I++ G S +
Sbjct: 207 GFFTPTKKISATSIFFESMPYKVNPETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDY 266
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
+ +VGA+++ D AHV G++A G P E ADI+T +THKT GP+ GVI ++
Sbjct: 267 ARFRQICDDVGAYLMADMAHVAGIVAAGLIPSPF-EWADIVTTTTHKTLRGPRAGVIFFR 325
Query: 240 K-----FADDETI-----AKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGE--AYAKQ 287
K A+ + + ++ A+FP + H + +AG + TA + + E AY Q
Sbjct: 326 KGVRSTKANGDKVLYDLEERINQAVFPSLQGGPHNNAVAG-IATAFKQAKSPEFKAYQTQ 384
Query: 288 IVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIIL 345
++KNAKAL + L G++V G T H V+VDV AG G A +LEE GI
Sbjct: 385 VLKNAKALCDGLISRGYQVA---TGGTDVHLVLVDV---RKAGLTGAKAEYILEEVGIAC 438
Query: 346 NKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
NKN +P D + PSG+R+G +T G+ E +++++ F+ L
Sbjct: 439 NKNTVPGD--KSAMNPSGIRLGTPALTTRGLAEQDIEQVVAFIDAAL 483
>gi|4759106 serine hydroxymethyltransferase 1 (soluble); cytoplasmic serine
hydroxymethyltransferase [Homo sapiens]
>gi|11427860|ref|XP_008637.1| serine
hydroxymethyltransferase 1 (soluble) [Homo sapiens]
>gi|462184|sp|P34896|GLYC_HUMAN SERINE
HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|539603|pir||A46746 glycine hydroxymethyltransferase
(EC 2.1.2.1), cytosolic - human
>gi|307422|gb|AAA63257.1| (L11931) serine
hydroxymethyltransferase [Homo sapiens]
>gi|438636|gb|AAA36020.1| (L23928) serine
hydroxymethyltransferase [Homo sapiens]
>gi|5830436|emb|CAB54838.1| (Y14485) cytosolic serine
hydroxymethyltransferase [Homo sapiens]
Length = 483
Score = 191 bits (481), Expect = 1e-47
Identities = 128/404 (31%), Positives = 213/404 (52%), Gaps = 30/404 (7%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 32 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 91
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E + + + +K D +++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 92 LETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 151
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R PK+++ G S +
Sbjct: 152 GFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEY 211
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A E GA+++ D AH+ GL+A G P E ++T +THKT G + G+I Y+
Sbjct: 212 ARLRKIADENGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGCRAGMIFYR 270
Query: 240 ---KFADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAK 286
K D +T ++ + A+FPG+ H H +AG + A LE+ + Y
Sbjct: 271 KGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEF-KVYQH 329
Query: 287 QIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILN 346
Q+V N +AL+EAL E G+K++ G + +H ++VD+ GG A +LE I N
Sbjct: 330 QVVANCRALSEALTELGYKIV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEACSIACN 385
Query: 347 KNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
KN P D PSGLR+G +T G++E + +++AHF+ R
Sbjct: 386 KNTCPGD--RSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHR 427
>sp|P50433|GLYM_SOLTU SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|481944|pir||S40218 glycine hydroxymethyltransferase
(EC 2.1.2.1) - potato >gi|438247|emb|CAA81082.1|
(Z25863) glycine hydroxymethyltransferase [Solanum
tuberosum]
Length = 518
Score = 191 bits (480), Expect = 1e-47
Identities = 132/408 (32%), Positives = 208/408 (50%), Gaps = 36/408 (8%)
Query: 5 EYRDKVLHFIEEHEKWRSHT-INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
E D + I EHEK R + LI SEN TS SV +AV S +KY+EG+P RYY G
Sbjct: 57 EVVDPEIADIIEHEKARQWKGLELIPSENFTSVSVMQAVGSVMTNKYSEGYPGARYYGGN 116
Query: 64 KYVDEVELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+Y+D E + + + F+ D A +++P+SG+ AN V+ L +P ++++ L HG
Sbjct: 117 EYIDMAETLCQKRALEAFRLDPAKWGVNVQPLSGSPANFQVYTALLKPHERIMALDLPHG 176
Query: 120 GHISH------MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLF 173
GH+SH A + E + D + ID D+ EK PK++V G S +
Sbjct: 177 GHLSHGYQTDTKKISAVSI-FFETMPYRLDESTGYIDYDQLEKSATLFRPKLIVAGASAY 235
Query: 174 PFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQG 233
+ + V + A ++ D AH+ GL+A G P + AD++T +THK+ GP+G
Sbjct: 236 ARLYDYDRIRKVCNKQKAILLADMAHISGLVAAGVIPSPF-DYADVVTTTTHKSLRGPRG 294
Query: 234 GVILYKK------------FADDETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLE 279
+I Y+K F D E K+ A+FPG+ H H + G + A E
Sbjct: 295 AMIFYRKGVKEVNKQGKEVFYDYED--KINQAVFPGLQGGPHNHTITGLAVALKQATTPE 352
Query: 280 YGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLE 339
Y AY +Q++ N+ A+AL E+G++++ G T +H V+V++ + G +LE
Sbjct: 353 Y-RAYQEQVLSNSSKFAQALGEKGYELV---SGGTDNHLVLVNMKN-KGIDGSRVEKVLE 407
Query: 340 EAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHF 387
I NKN +P D V P G+R+G +T G +E++ ++A F
Sbjct: 408 AVHIAANKNTVPGDVSAMV--PGGIRMGTPALTSRGFLEEDFVKVADF 453
>pdb|1BJ4|A Chain A, Recombinant Serine Hydroxymethyltransferase (Human)
Length = 470
Score = 190 bits (479), Expect = 2e-47
Identities = 128/404 (31%), Positives = 212/404 (51%), Gaps = 30/404 (7%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 22 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 81
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E + + + +K D +++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 82 LETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 141
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R PK+++ G S +
Sbjct: 142 GFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEY 201
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A E GA+++ D AH+ GL+A G P E ++T +THKT G + G+I Y+
Sbjct: 202 ARLRKIADENGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGCRAGMIFYR 260
Query: 240 ---KFADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAK 286
K D T ++ + A+FPG+ H H +AG + A LE+ + Y
Sbjct: 261 KGVKSVDPATGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEF-KVYQH 319
Query: 287 QIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILN 346
Q+V N +AL+EAL E G+K++ G + +H ++VD+ GG A +LE I N
Sbjct: 320 QVVANCRALSEALTELGYKIV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEACSIACN 375
Query: 347 KNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
KN P D PSGLR+G +T G++E + +++AHF+ R
Sbjct: 376 KNTCPGD--RSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHR 417
>pir||B71400 glycine hydroxymethyltransferase (EC 2.1.2.1) - Arabidopsis
thaliana >gi|2244749|emb|CAB10172.1| (Z97335)
hydroxymethyltransferase [Arabidopsis thaliana]
>gi|7268097|emb|CAB78435.1| (AL161537)
hydroxymethyltransferase [Arabidopsis thaliana]
Length = 471
Score = 189 bits (474), Expect = 7e-47
Identities = 137/441 (31%), Positives = 218/441 (49%), Gaps = 44/441 (9%)
Query: 8 DKVLHFIEEHEKWRS-HTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYV 66
D +H + E EK R I LIASEN TS +V A+ S +KY+EG P RYY G +++
Sbjct: 16 DPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGIPGNRYYGGNEFI 75
Query: 67 DEVELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHI 122
DE+E + + F D A +++P SG+ AN A + L QP D+++ L GGH+
Sbjct: 76 DEIENLCRSRALEAFHCDPAAWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHL 135
Query: 123 SHMPFGAAGMR----GLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFP 176
+H + + G + + + P+ + + ID DK E+ + PK+++ GGS +P
Sbjct: 136 THGYYTSGGKKISATSIYFESLPYKVNFTTGYIDYDKLEEKALDFRPKLLICGGSAYPRD 195
Query: 177 HPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVI 236
+A +VGA ++ D AH+ GL+A E +P E D++T +THK+ GP+ G+I
Sbjct: 196 WDYARFRAIADKVGALLLCDMAHISGLVAAQEAANPF-EYCDVVTTTTHKSLRGPRAGMI 254
Query: 237 LYKK-----------FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EAY 284
Y+K A + K+ +A+FP + H H + + + G + Y
Sbjct: 255 FYRKGPKPPKKGQPEGAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQANTPGFKVY 314
Query: 285 AKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAG 342
AKQ+ NA AL L +G++++ T++H V+ DL P G G L +
Sbjct: 315 AKQVKANAVALGNYLMSKGYQIVTNG---TENHLVL---WDLRPLGLTGNKVEKLCDLCS 368
Query: 343 IILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKEDPKKVR 402
I LNKN + D P G+RIG MT G++E + ++I F+ R + D +K
Sbjct: 369 ITLNKNAVFGD--SSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLSRAVTLTLDIQKT- 425
Query: 403 KDVYYFRLEYQKVYYSFDYGL 423
Y K+ F+ GL
Sbjct: 426 ---------YGKLLKDFNKGL 437
>emb|CAB94023.1| (AL358652) (mitochondrial?) serine hydroxymethyltransferase
[Leishmania major]
Length = 465
Score = 189 bits (474), Expect = 7e-47
Identities = 124/384 (32%), Positives = 196/384 (50%), Gaps = 24/384 (6%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ +IASEN+TS +V + S +KYAEG P RYY G +VD VE + + F D
Sbjct: 30 LEMIASENLTSKAVLECLGSALTNKYAEGEPGNRYYGGTVFVDMVENLAKKRALAAFGLD 89
Query: 85 YAD----LRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH---MPFGAAGMRGLEV 137
+ ++P SG+ AN AV+ L +P +++ L GGH++H P +
Sbjct: 90 PGEWGVNVQPYSGSPANFAVYTALLEPHSRIMGLDLPSGGHLTHGFYTPKKKVSATSIYF 149
Query: 138 HTWPFD-NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYD 196
++P+ E ID D E + PK+++ G S + + V EVG+ + D
Sbjct: 150 ESFPYHVKEDGLIDYDALESVALVFRPKMIITGASAYARDFDYERFRHVCDEVGSLLFMD 209
Query: 197 AAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKF------ADDETIAKL 250
AH GLIAGG + P AD++T +THK+ GP+ G+I Y+K D E +++
Sbjct: 210 MAHTAGLIAGGVLKSPF-PYADVVTTTTHKSLRGPRAGMIFYRKKDRQGKPTDHE--SRI 266
Query: 251 QWAIFPGVLSNHHLHHMAGKVITAAEML-EYGEAYAKQIVKNAKALAEALAEEGFKVIGE 309
A+FPG H H +A E+ + +AYA+Q+ NA+ALA AL+ +G +
Sbjct: 267 NQAVFPGCQGGPHEHQIAAIATQMREVCSQEWKAYARQVQSNARALAAALSSKGHVFV-- 324
Query: 310 DQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQ 369
G T +H ++ +V +H G LL+ I +NKN +P D + P G+R+G
Sbjct: 325 -SGGTDNHLLLWNVR-VHGLTGSKVEKLLDAVSISVNKNTIPGD--KSAMTPGGIRVGTL 380
Query: 370 EMTRVGMMEDEMKEIAHFMKRVLL 393
+T GM+E +M +A F+ R ++
Sbjct: 381 ALTSRGMVEADMSTVAEFLDRAIV 404
>sp|P35623|GLYC_SHEEP SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|2136860|pir||S65688 glycine hydroxymethyltransferase
(EC 2.1.2.1) - sheep >gi|7433543|pir||A40202 glycine
hydroxymethyltransferase (EC 2.1.2.1), cytosolic - sheep
>gi|2407962|emb|CAA56326.1| (X80024) serine
hydroxymethyl transferase [Ovis aries]
Length = 484
Score = 187 bits (471), Expect = 2e-46
Identities = 123/403 (30%), Positives = 214/403 (52%), Gaps = 28/403 (6%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 32 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 91
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E++ + +++ D +++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 92 LEVLCQKRALQVYGLDPECWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 151
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R P++++ G S +
Sbjct: 152 GFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNLDY 211
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A + GA+++ D AH+ GL+A G P E +++ +THKT G + G+I Y+
Sbjct: 212 ARLRKIADDNGAYLMADMAHISGLVAAGVVPSPF-EHCHVVSTTTHKTLRGCRAGMIFYR 270
Query: 240 K---FADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQ 287
K D +T + ++ A+FPG+ H H +AG + + M AY +Q
Sbjct: 271 KGVRSVDPKTGKETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRAYQRQ 330
Query: 288 IVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNK 347
+V N +ALAEAL G++V+ G + +H ++VD+ GG A +LE I NK
Sbjct: 331 VVANCRALAEALMGLGYRVV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEACSIACNK 386
Query: 348 NLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
N P D + PSGLR+G +T G++E++ +++AHF+ R
Sbjct: 387 NTCPGD--KSALRPSGLRLGTPALTSRGLLEEDFRKVAHFIHR 427
>gb|AAF86546.1|AC069252_5 (AC069252) F2E2.7 [Arabidopsis thaliana]
Length = 599
Score = 187 bits (469), Expect = 3e-46
Identities = 134/415 (32%), Positives = 213/415 (51%), Gaps = 37/415 (8%)
Query: 5 EYRDKVLHFIEEHEKWRSHT-INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
E D +H E EK R I LIASEN +V A+ S +KY+EG P RYY G
Sbjct: 143 EEADPEIHEFMEKEKQRQFRGIELIASENFVCRAVMEALGSHLTNKYSEGMPGARYYTGN 202
Query: 64 KYVDEVELIGVELFTKLFKSDY----ADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+Y+D++E++ E F ++ +++P S T+AN AVF GL PG++++ L + G
Sbjct: 203 QYIDQIEILCQERALAAFGLNHEKWGVNVQPYSCTSANFAVFTGLLMPGERIMGLDSPSG 262
Query: 120 GHISHMPFGAAGMR----GLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLF 173
GH+SH + G + + ++P+ D + ID DK E+ + PKI++ GGS +
Sbjct: 263 GHMSHGYYTPGGKKVSGASIFFESFPYKVDPRTGYIDYDKLEEKALDYRPKILICGGSSY 322
Query: 174 PFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQG 233
P +A + GA +++D A + GL+A E +P + DI+T++THK+ GP+G
Sbjct: 323 PRDWEFPRFRHIADKCGAVLMFDMAQISGLVAAKESPNPF-DYCDIVTSTTHKSLRGPRG 381
Query: 234 GVILYKKFADDETIA----------------KLQWAIFPGVLSNHHLHHMAGKVIT--AA 275
G+I YK+ + + K+ +++FP + H +H+A I A
Sbjct: 382 GIIFYKRGLKPKKQSINLNHCESNIQYDFEEKINFSVFPSLQGGPHNNHIAALAIALKQA 441
Query: 276 EMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAA 335
EY + Y +Q+ KNAKALA AL K+I G T +H ++ D++ L G +
Sbjct: 442 ASPEY-KLYMRQVKKNAKALASALISRKCKLI---TGGTDNHLLLWDLTPLGLTGKVY-E 496
Query: 336 PLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
+ E I +NK + + V P G+RIG MT G +E E + +A F+ R
Sbjct: 497 KVCEMCHITVNKVAIFSE--NGVISPGGVRIGSPAMTSRGCLEPEFETMADFLYR 549
>sp|P07511|GLYC_RABIT SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|2144397|pir||XYRBSC glycine hydroxymethyltransferase
(EC 2.1.2.1), cytosolic - rabbit
>gi|1537|emb|CAA77870.1| (Z11846) cytosolic serine
hydroxymethyltransferase [Oryctolagus cuniculus]
Length = 484
Score = 186 bits (468), Expect = 4e-46
Identities = 125/409 (30%), Positives = 213/409 (51%), Gaps = 30/409 (7%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
K+ +V I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G
Sbjct: 27 KDSDAEVYDIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGT 86
Query: 64 KYVDEVELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+++DE+E + + + + D +++P SG+ AN AV+ L +P +++ L G
Sbjct: 87 EHIDELETLCQKRALQAYGLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDG 146
Query: 120 GHISH-----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFP 174
GH++H +A E + + ++ ID D+ E+ R PK+++ G S +
Sbjct: 147 GHLTHGFMTDKKKISATSIFFESMAYKVNPDTGYIDYDRLEENARLFHPKLIIAGTSCYS 206
Query: 175 FPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGG 234
L +A E GA+++ D AH+ GL+ G P E ++T +THKT G + G
Sbjct: 207 RNLDYGRLRKIADENGAYLMADMAHISGLVVAGVVPSPF-EHCHVVTTTTHKTLRGCRAG 265
Query: 235 VILYK---KFADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVITAAEML--EYG 281
+I Y+ + D +T ++ + A+FPG+ H H +AG + + + E+
Sbjct: 266 MIFYRRGVRSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFK 325
Query: 282 EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEA 341
E Y +Q+V N +AL+ AL E G+K++ G + +H ++VD+ GG A +LE
Sbjct: 326 E-YQRQVVANCRALSAALVELGYKIV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEAC 380
Query: 342 GIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
I NKN P D + PSGLR+G +T G++E + +++AHF+ R
Sbjct: 381 SIACNKNTCPGD--KSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHR 427
>sp|O53615|GLA2_MYCTU SERINE HYDROXYMETHYLTRANSFERASE 2 (SERINE METHYLASE 2) (SHMT 2)
>gi|7433540|pir||G70848 glycine hydroxymethyltransferase
(EC 2.1.2.1) glyA2 - Mycobacterium tuberculosis (strain
H37RV) >gi|2808727|emb|CAA16251.1| (AL021428) glyA2
[Mycobacterium tuberculosis]
Length = 425
Score = 186 bits (468), Expect = 4e-46
Identities = 131/387 (33%), Positives = 196/387 (49%), Gaps = 31/387 (8%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ +IASEN +V +A S +KYAEG+P +RYY GC++VD VE + ++ LF ++
Sbjct: 30 LEMIASENYAPLAVMQAQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAE 89
Query: 85 YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGAAGMR----GLEVHTW 140
YA+++P SG AN A L PGD ++ L +HGGH++H GMR G H
Sbjct: 90 YANVQPHSGATANAATMHALLNPGDTILGLSLAHGGHLTH------GMRINFSGKLYHAT 143
Query: 141 PFD--NESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAA 198
++ E + +D+D + R PK+++ G S +P +A EV A ++ D A
Sbjct: 144 AYEVSKEDYLVDMDAVAEAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMA 203
Query: 199 HVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIA-KLQWAIFPG 257
H GL+A G P+ A ++T++THKT GP+GG+IL +D IA K+ A+FPG
Sbjct: 204 HFAGLVAAGVHPSPVPH-AHVVTSTTHKTLGGPRGGIIL----CNDPAIAKKINSAVFPG 258
Query: 258 VLSNHHLHHMAGKVITAAEMLEYGEAYAKQ--IVKNAKALAEAL-----AEEGFKVIGED 310
H +A K TA +M E +Q + A+ LA L AE G V+
Sbjct: 259 QQGGPLEHVIAAKA-TAFKMAAQPEFAQRQQRCLDGARILAGRLTQPDVAERGIAVL--- 314
Query: 311 QGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQE 370
G T H V+VD+ D G A L I +N+N +P+DP + SGLRIG
Sbjct: 315 TGGTDVHLVLVDLRDAE-LDGQQAEDRLAAVDITVNRNAVPFDPRPPM-ITSGLRIGTPA 372
Query: 371 MTRVGMMEDEMKEIAHFMKRVLLDKED 397
+ G ++ + +A + L D
Sbjct: 373 LAARGFSHNDFRAVADLIAAALTATND 399
>pdb|1CJ0|A Chain A, Crystal Structure Of Rabbit Cytosolic Serine
Hydroxymethyltransferase At 2.8 Angstrom Resolution
>gi|5107550|pdb|1CJ0|B Chain B, Crystal Structure Of
Rabbit Cytosolic Serine Hydroxymethyltransferase At 2.8
Angstrom Resolution
Length = 470
Score = 186 bits (468), Expect = 4e-46
Identities = 125/409 (30%), Positives = 213/409 (51%), Gaps = 30/409 (7%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
K+ +V I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G
Sbjct: 13 KDSDAEVYDIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGT 72
Query: 64 KYVDEVELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+++DE+E + + + + D +++P SG+ AN AV+ L +P +++ L G
Sbjct: 73 EHIDELETLCQKRALQAYGLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDG 132
Query: 120 GHISH-----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFP 174
GH++H +A E + + ++ ID D+ E+ R PK+++ G S +
Sbjct: 133 GHLTHGFMTDKKKISATSIFFESMAYKVNPDTGYIDYDRLEENARLFHPKLIIAGTSCYS 192
Query: 175 FPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGG 234
L +A E GA+++ D AH+ GL+ G P E ++T +THKT G + G
Sbjct: 193 RNLDYGRLRKIADENGAYLMADMAHISGLVVAGVVPSPF-EHCHVVTTTTHKTLRGCRAG 251
Query: 235 VILYK---KFADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVITAAEML--EYG 281
+I Y+ + D +T ++ + A+FPG+ H H +AG + + + E+
Sbjct: 252 MIFYRRGVRSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFK 311
Query: 282 EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEA 341
E Y +Q+V N +AL+ AL E G+K++ G + +H ++VD+ GG A +LE
Sbjct: 312 E-YQRQVVANCRALSAALVELGYKIV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEAC 366
Query: 342 GIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
I NKN P D + PSGLR+G +T G++E + +++AHF+ R
Sbjct: 367 SIACNKNTCPGD--KSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHR 413
>pir||T05258 glycine hydroxymethyltransferase (EC 2.1.2.1) F18A5.280 -
Arabidopsis thaliana >gi|4455318|emb|CAB36853.1|
(AL035528) glycine hydroxymethyltransferase-like protein
[Arabidopsis thaliana] >gi|7268093|emb|CAB78431.1|
(AL161537) glycine hydroxymethyltransferase-like protein
[Arabidopsis thaliana]
Length = 470
Score = 186 bits (467), Expect = 5e-46
Identities = 135/429 (31%), Positives = 217/429 (50%), Gaps = 38/429 (8%)
Query: 5 EYRDKVLHFIEEHEKWRS-HTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
++ D ++ + E EK R I LIA+EN TS +V A+ S +KY+EG P RYY G
Sbjct: 13 DFVDPEIYDLIEKEKHRQCRGIELIAAENFTSVAVMEALGSCLTNKYSEGMPGNRYYGGT 72
Query: 64 KYVDEVELI----GVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+++DE+E + +E F + +++P SG+ AN A + L QP D+++ L G
Sbjct: 73 EFIDEIESLCRSRSLEAFHCNPEKWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSG 132
Query: 120 GHISHMPFGAAGMR----GLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLF 173
GHI+H + + G + P+ D+++ ID DK E+ + PK+++ GG+ +
Sbjct: 133 GHITHGYYSSGGKNISATSIYFENLPYKVDSKTGYIDYDKLEEKAMDFRPKLIICGGTSY 192
Query: 174 PFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQG 233
P VA +VGAF++ D AH L+A E DP E D++T STHK+ GP+
Sbjct: 193 PREWDYARFRAVADKVGAFLLCDMAHNSALVAAQEAADPF-EYCDVVTTSTHKSLRGPRA 251
Query: 234 GVILYKKFADD-----------ETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG- 281
G+I Y+K + AK+ A+FP + S H + + + +++
Sbjct: 252 GMIFYRKGPKPAKKGQPEGEVYDFDAKINSAVFPALQSGPHNNKIGALAVALKQVMAPSF 311
Query: 282 EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLE 339
+ YAKQ+ NA LA L +G+ ++ + T +H ++ DL P G G + E
Sbjct: 312 KVYAKQVKANAACLASYLINKGYTLVTDG---TDNHLIL---WDLRPLGLTGNKVEKVCE 365
Query: 340 EAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR---VLLD-K 395
I LN+N + D P G+RIG MT G++E + ++I F+ R + LD +
Sbjct: 366 LCYITLNRNAVFGD--TSFLAPGGVRIGTPAMTSRGLVEKDFEKIGEFLHRAVTITLDIQ 423
Query: 396 EDPKKVRKD 404
E KV KD
Sbjct: 424 EQYGKVMKD 432
>pir||S40497 serine hydroxymethyltransferase - sheep >gi|545298|gb|AAB29853.1|
serine hydroxymethyltransferase, SHMT {EC 2.1.2.1}
[sheep, liver, cytosol, Peptide, 483 aa]
Length = 483
Score = 185 bits (466), Expect = 6e-46
Identities = 124/404 (30%), Positives = 214/404 (52%), Gaps = 30/404 (7%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 31 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 90
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E++ + +++ D + +P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 91 LEVLCQKRALQVYGLDPECFGVNYQPYSGSPANFAVYTALVEPHARIMGLDLPDGGHLTH 150
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R PK+++ G S +
Sbjct: 151 GFMTDKKKISATSIFFESMAYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLDY 210
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A E GA+++ D AH+ GL+A G P E ++T +THKT G + G+I Y+
Sbjct: 211 ARLRKIADENGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGCRAGMIFYR 269
Query: 240 K---FADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVITAAEML--EYGEAYAK 286
K D +T + ++ A+FPG+ H H +AG + + + E+ E Y +
Sbjct: 270 KGVRSVDPKTGKETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFKE-YQR 328
Query: 287 QIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILN 346
Q+V N +AL+ AL G++V+ G + +H ++VD+ GG A +LE I N
Sbjct: 329 QVVANCRALSAALMGLGYRVV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEACSIACN 384
Query: 347 KNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
KN P D + PSGLR+G +T G++E++ +++AHF+ R
Sbjct: 385 KNTCPGD--KSALRPSGLRLGTPALTSRGLLEEDFEKVAHFIHR 426
>pir||S72452 glycine hydroxymethyltransferase (EC 2.1.2.1) - sheep
Length = 484
Score = 185 bits (466), Expect = 6e-46
Identities = 122/403 (30%), Positives = 213/403 (52%), Gaps = 28/403 (6%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 32 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 91
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E++ + +++ D +++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 92 LEVLCQKRALQVYGLDPECWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 151
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R P++++ G S +
Sbjct: 152 GFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNLDY 211
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A + GA+++ D AH+ GL+A G P E +++ +THKT G + G+I Y+
Sbjct: 212 ARLRKIADDNGAYLMADMAHISGLVAAGVVPSPF-EHCHVVSTTTHKTLRGCRAGMIFYR 270
Query: 240 K---FADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQ 287
K D +T + ++ A+FPG+ H H +AG + + M AY +Q
Sbjct: 271 KGVRSVDPKTGKETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRAYQRQ 330
Query: 288 IVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNK 347
+V N +ALAEAL G++V+ G + +H ++VD+ GG A +LE I NK
Sbjct: 331 VVANCRALAEALMGLGYRVV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEACSIACNK 386
Query: 348 NLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
N P D + PSG R+G +T G++E++ +++AHF+ R
Sbjct: 387 NTCPGD--KSALRPSGCRLGTPALTSRGLLEEDFRKVAHFIHR 427
>sp|P34899|GLYM_PEA SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|282928|pir||A42906 glycine hydroxymethyltransferase
(EC 2.1.2.1) - garden pea >gi|169158|gb|AAA33687.1|
(M87649) serine hydroxymethyltransferase [Pisum sativum]
Length = 518
Score = 185 bits (464), Expect = 1e-45
Identities = 124/398 (31%), Positives = 206/398 (51%), Gaps = 37/398 (9%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
+E+ +W+ + LI SEN TS SV +AV S +KY+EG+P RYY G +Y+D E +
Sbjct: 69 LEKARQWKG--LELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLC 126
Query: 74 VELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH----- 124
+ + F+ D A +++P+SG+ +N V+ L +P D+++ L HGGH+SH
Sbjct: 127 QKRALEAFRLDPAKWGVNVQPLSGSPSNFQVYTALLKPHDRIMALDLPHGGHLSHGYQTD 186
Query: 125 -MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELA 183
A + E + D + ID D+ EK PK++V G S + + +
Sbjct: 187 TKKISAVSI-FFETMPYRLDESTGYIDYDQLEKSATLFRPKLIVAGASAYARLYDYARIR 245
Query: 184 PVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK--- 240
V + A ++ D AH+ GL+A G P + AD++T +THK+ GP+G +I ++K
Sbjct: 246 KVCDKQKAVLLADMAHISGLVAAGVIPSPF-DYADVVTTTTHKSLRGPRGAMIFFRKGLK 304
Query: 241 ---------FADDETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAKQIV 289
F D E K+ A+FPG+ H H + G + A EY AY +Q++
Sbjct: 305 EVNKQGKEVFYDYED--KINQAVFPGLQGGPHNHTITGLAVALKQATTPEY-RAYQEQVL 361
Query: 290 KNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNL 349
N+ A+AL+E+G+ ++ G T++H V+V++ + G +LE I NKN
Sbjct: 362 SNSSKFAKALSEKGYDLV---SGGTENHLVLVNLKN-KGIDGSRVEKVLELVHIAANKNT 417
Query: 350 LPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHF 387
+P D V P G+R+G +T G +E++ ++A +
Sbjct: 418 VPGDVSAMV--PGGIRMGTPALTSRGFVEEDFVKVAEY 453
>sp|P49357|GLYM_FLAPR SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL 1 PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|481942|pir||S40212 glycine hydroxymethyltransferase
(EC 2.1.2.1) isoform 1 - Flaveria pringlei
>gi|437995|emb|CAA81078.1| (Z25859) glycine
hydroxymethyltransferase [Flaveria pringlei]
Length = 517
Score = 184 bits (463), Expect = 1e-45
Identities = 126/397 (31%), Positives = 206/397 (51%), Gaps = 35/397 (8%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
+E+ +W+ + LI SEN TS SV +AV S +KY+EG+P RYY G +Y+D E +
Sbjct: 69 LEKARQWKG--LELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLC 126
Query: 74 VELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH---MP 126
+ + F+ D A +++P+SG+ AN V+ L + D+++ L HGGH+SH
Sbjct: 127 QKRALEAFRLDPAKWGVNVQPLSGSPANFHVYTALLKAHDRIMALDLPHGGHLSHGYQTD 186
Query: 127 FGAAGMRGLEVHTWPFD-NESFN-IDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAP 184
+ T P+ NES ID D+ EK PK++V G S + + +
Sbjct: 187 TKKISAVSIFFETMPYRLNESTGYIDYDQLEKSATLFRPKLIVAGASAYARLYDYARIRK 246
Query: 185 VAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK---- 240
V + A ++ D AH+ GL+A G P + AD++T +THK+ GP+G +I ++K
Sbjct: 247 VCDKQKAIMLADMAHISGLVAAGVIPSPF-DYADVVTTTTHKSLRGPRGAMIFFRKGLKE 305
Query: 241 --------FADDETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAKQIVK 290
F D E K+ A+FPG+ H H + G + A EY +AY +Q++
Sbjct: 306 VNKQGKEVFYDYED--KINQAVFPGLQGGPHNHTITGLAVALKQATTAEY-KAYQEQVMS 362
Query: 291 NAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLL 350
N+ AE L + G++++ G T++H V+V++ + G +LE I NKN +
Sbjct: 363 NSAKFAETLVKSGYELV---SGGTENHLVLVNLKN-KGIDGSKVEKVLEAVHIAANKNTV 418
Query: 351 PWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHF 387
P D V P G+R+G +T G +E++ ++A+F
Sbjct: 419 PGDVSAMV--PGGIRMGTPALTSRGFVEEDFAKVAYF 453
>sp|Q9X794|GLYA_MYCLE SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|4539107|emb|CAB39828.1| (AL049491) putative serine
hydroxymethyltransferase [Mycobacterium leprae]
Length = 426
Score = 183 bits (461), Expect = 2e-45
Identities = 129/374 (34%), Positives = 192/374 (50%), Gaps = 14/374 (3%)
Query: 24 TINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKS 83
T+ +IASEN SV +A S +KYAEG P +RYY GC++VD VE I + LF +
Sbjct: 26 TLEMIASENFVPRSVLQAQGSVLTNKYAEGLPGRRYYDGCEHVDVVENIARDRAKALFGA 85
Query: 84 DYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MPFGAAGMRGLEVHTWPF 142
D+A+++P SG AN AV L PG++++ L ++GGH++H M +G + E +
Sbjct: 86 DFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSG-KLYETGFYGV 144
Query: 143 DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLG 202
D + ID+D E PK+++ G S +P +A EVGA + D AH G
Sbjct: 145 DATTHLIDMDAVRAKALEFRPKVLIAGWSAYPRILDFAAFRSIADEVGAKLWVDMAHFAG 204
Query: 203 LIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNH 262
L+A G P+ AD+++ + HKT G + G+IL K+ E + A+FPG
Sbjct: 205 LVAVGLHPSPVPH-ADVVSTTVHKTLGGGRSGLILGKQ----EFATAINSAVFPGQQGGP 259
Query: 263 HLHHMAGKVIT--AAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGED--QGYTKSHQ 318
+H +AGK + A E+ + + + A+ LA+ L G G T H
Sbjct: 260 LMHVIAGKAVALKIATTPEFTDRQQRTLA-GARILADRLTAADVTKAGVSVVSGGTDVHL 318
Query: 319 VIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMME 378
V+VD+ + P G A LL E GI +N+N++P DP + SGLRIG + G E
Sbjct: 319 VLVDLRN-SPFDGQAAEDLLHEVGITVNRNVVPNDPRPPM-VTSGLRIGTPALATRGFGE 376
Query: 379 DEMKEIAHFMKRVL 392
E E+A + VL
Sbjct: 377 AEFTEVADIIATVL 390
>sp|O13426|GLYC_CANAL SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT) (SHMII)
>gi|2282058|gb|AAB64197.1| (AF009966) serine
hydroxymethyl transferase II [Candida albicans]
Length = 470
Score = 183 bits (459), Expect = 4e-45
Identities = 135/424 (31%), Positives = 217/424 (50%), Gaps = 31/424 (7%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
K+ +V I++ + H+I LIASEN T+ +V A+ + +KY+EG+P RYY G
Sbjct: 19 KDTDPEVDQIIKDEIDRQQHSIVLIASENFTTTAVFDALGTPMCNKYSEGYPGARYYGGN 78
Query: 64 KYVDEVELIGVELFTKLF----KSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+++ +EL+ E K F +++ +SG+ AN V+ + +P ++++ L HG
Sbjct: 79 EHIHRMELLCQERALKAFGLTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLDLPHG 138
Query: 120 GHISH-----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFP 174
GH+SH +A E + D E+ ID D EK PK++V G S +
Sbjct: 139 GHLSHGYQTDSRKISAVSTYFETMPYRVDLETGLIDYDMLEKTAVLYRPKVLVAGTSAYC 198
Query: 175 FPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGG 234
K + +A +VGA++V D AH+ GLIA G P E ADI+T +THK+ GP+G
Sbjct: 199 RLIDYKRMREIADKVGAYLVVDMAHISGLIAAGVIPSPF-EYADIVTTTTHKSLRGPRGA 257
Query: 235 VILYKK-------FADDETIAKLQ----WAIFPGVLSNHHLHHMA--GKVITAAEMLEYG 281
+I +++ E + L+ +++FPG H H +A + A E+
Sbjct: 258 MIFFRRGVRSVNPKTGQEILYDLENPINFSVFPGHQGGPHNHTIAALATALKQANTPEFK 317
Query: 282 EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEA 341
E Y +Q++KNAKAL ++G+K++ + T SH V+V + D G + E+
Sbjct: 318 E-YQEQVLKNAKALESEFTKKGYKLVSDG---TDSHMVLVSLKD-KQIDGARVETVCEKI 372
Query: 342 GIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMK-RVLLDKEDPKK 400
I LNKN +P D V P G+RIG MT G+ E++ K+I ++ V KE +
Sbjct: 373 NIALNKNSIPGDKSALV--PGGVRIGAPAMTTRGLGEEDFKKIVSYIDFAVNYAKEVQSQ 430
Query: 401 VRKD 404
+ KD
Sbjct: 431 LPKD 434
>pir||T05620 glycine hydroxymethyltransferase (EC 2.1.2.1) F20D10.50 -
Arabidopsis thaliana >gi|4467099|emb|CAB37533.1|
(AL035538) glycine hydroxymethyltransferase like protein
[Arabidopsis thaliana] >gi|6899945|emb|CAB71289.1|
(AJ271726) serine hydroxymethyl transferase [Arabidopsis
thaliana] >gi|7270776|emb|CAB80458.1| (AL161592) glycine
hydroxymethyltransferase like protein [Arabidopsis
thaliana]
Length = 517
Score = 182 bits (457), Expect = 7e-45
Identities = 125/404 (30%), Positives = 204/404 (49%), Gaps = 36/404 (8%)
Query: 14 IEEHEKWRSHT-INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELI 72
I EHEK R + LI SEN TS SV +AV S +KY+EG+P RYY G +Y+D E +
Sbjct: 65 IIEHEKARQWKGLELIPSENFTSVSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETL 124
Query: 73 GVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH---- 124
+ + F+ D +++P+SG+ AN V+ L +P ++++ L HGGH+SH
Sbjct: 125 CQKRALEAFRLDPEKWGVNVQPLSGSPANFHVYTALLKPHERIMALDLPHGGHLSHGYQT 184
Query: 125 --MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKEL 182
A + E + D + ID D+ EK PK++V G S + + +
Sbjct: 185 DTKKISAVSI-FFETMPYRLDESTGYIDYDQMEKSATLFRPKLIVAGASAYARLYDYARI 243
Query: 183 APVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFA 242
V + A ++ D AH+ GL+A P + AD++T +THK+ GP+G +I ++K
Sbjct: 244 RKVCNKQKAVMLADMAHISGLVAANVIPSPF-DYADVVTTTTHKSLRGPRGAMIFFRKGV 302
Query: 243 DD----------ETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAKQIVK 290
+ + K+ A+FPG+ H H + G + A EY +AY +Q++
Sbjct: 303 KEINKQGKEVLYDFEDKINQAVFPGLQGGPHNHTITGLAVALKQATTSEY-KAYQEQVLS 361
Query: 291 NAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKN 348
N+ A+ L E G++++ G T +H V+V +L P G G +LE I NKN
Sbjct: 362 NSAKFAQTLMERGYELV---SGGTDNHLVLV---NLKPKGIDGSRVEKVLEAVHIASNKN 415
Query: 349 LLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
+P D V P G+R+G +T G +E++ ++A + + +
Sbjct: 416 TVPGDVSAMV--PGGIRMGTPALTSRGFVEEDFAKVAEYFDKAV 457
>sp|Q10104|GLY1_SCHPO PROBABLE SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|7493372|pir||T37918 serine hydroxymethyltransferase
- fission yeast (Schizosaccharomyces pombe)
>gi|1122369|emb|CAA92384.1| (Z68198) serine
hydroxymethyltransferase [Schizosaccharomyces pombe]
Length = 472
Score = 182 bits (456), Expect = 9e-45
Identities = 128/407 (31%), Positives = 202/407 (49%), Gaps = 30/407 (7%)
Query: 8 DKVLHFIEEHEKWRS-HTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYV 66
D ++ I E EK R +I LIASEN TS +V A+ S +KY+EG+P RYY G +++
Sbjct: 22 DPTVYKILESEKSRQKESIALIASENFTSRAVMDALGSIMQNKYSEGYPGARYYGGNEFI 81
Query: 67 DEVELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHI 122
D+ E + + F D +++P SG+ AN + + +P D+++ L HGGH+
Sbjct: 82 DQAERLCQTRALEAFHLDGEKWGVNVQPHSGSPANLQAYQAVMKPHDRLMGLDLPHGGHL 141
Query: 123 SH---MPFGAAGMRGLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPH 177
SH P A T P+ + E+ ID D EK + PK++V G S +
Sbjct: 142 SHGFSTPQKAISAVSTYFSTMPYNVNKETGIIDYDSLEKAAIQFRPKVIVAGASAYARLV 201
Query: 178 PVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVIL 237
K + + + A+++ D AH+ GL+A G P E ADI+T +THK+ GP+G +I
Sbjct: 202 DYKRMRKITEMCNAYLLCDMAHISGLVAAGVIPSPF-EYADIVTTTTHKSLRGPRGAMIF 260
Query: 238 YKKFADD----------ETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYA 285
Y+K E K+ +++FPG H H + + A+ E+ + Y
Sbjct: 261 YRKGTRSHDKRGNPILYELEDKINFSVFPGHQGGPHNHTITALAVALGQAKTPEFYQ-YQ 319
Query: 286 KQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIIL 345
K ++ NAKA+A A G+K++ G T +H V+VD++D G +LE I
Sbjct: 320 KDVLSNAKAMANAFITRGYKLV---SGGTDTHLVLVDLTD-KGVDGARVERILELVNISA 375
Query: 346 NKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
NKN +P D + P GLR+G T G E + + + + V+
Sbjct: 376 NKNTVPGDKSALI--PRGLRLGTPACTTRGFDEKDFERVVELIDEVV 420
>sp|P50432|GLYC_CAEEL SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (GLYCINE
HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|485099|gb|AAB53830.1| (U00048) Contains similarity
to Pfam domain: PF00464 (SHMT), Score=954.1,
E-value=9.9e-287, N=1 [Caenorhabditis elegans]
Length = 484
Score = 181 bits (455), Expect = 1e-44
Identities = 122/402 (30%), Positives = 205/402 (50%), Gaps = 31/402 (7%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V ++ +K + + LIASEN TS +V A+ S +KY+EG+P RYY G +++D+
Sbjct: 35 EVFDIMKNEKKRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNEFIDQ 94
Query: 69 VELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+EL+ + ++F D A +++P+SG+ AN AV+ + +++ L GGH++H
Sbjct: 95 MELLCQKRALEVFGLDPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLPDGGHLTH 154
Query: 125 MPFG-----AAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
F +A + + D + ID DK E+ PK ++ G S +
Sbjct: 155 GFFTPARKVSATSEFFQSLPYKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVSCYARHLDY 214
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
+ +A + GA+++ D AH+ GL+A G P E +D++T +THK+ GP+G +I Y+
Sbjct: 215 ERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPF-EYSDVVTTTTHKSLRGPRGALIFYR 273
Query: 240 KFADD----------ETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEML-EYGEAYAKQI 288
K + K+ A+FPG+ H H +AG + + L E Y +Q+
Sbjct: 274 KGVRSTNAKGVDTLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALRQCLSEDFVQYGEQV 333
Query: 289 VKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILN 346
+KNAK LAE + + G+ + G T +H ++V DL P G G A +L+ A I N
Sbjct: 334 LKNAKTLAERMKKHGYALA---TGGTDNHLLLV---DLRPIGVEGARAEHVLDLAHIACN 387
Query: 347 KNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFM 388
KN P D P G+R+G +T G E + +++ F+
Sbjct: 388 KNTCPGD--VSALRPGGIRLGTPALTSRGFQEQDFEKVGDFI 427
>sp|P49358|GLYN_FLAPR SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL 2 PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|481943|pir||S40213 glycine hydroxymethyltransferase
(EC 2.1.2.1) isoform 2 - Flaveria pringlei
>gi|437997|emb|CAA81079.1| (Z25860) glycine
hydroxymethyltransferase [Flaveria pringlei]
Length = 517
Score = 181 bits (454), Expect = 2e-44
Identities = 122/394 (30%), Positives = 203/394 (50%), Gaps = 31/394 (7%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
+E+ +W+ + LI SEN TS SV +AV S +KY+EG+P RYY G +Y+D E +
Sbjct: 69 LEKARQWKG--LELILSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLC 126
Query: 74 VELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH---MP 126
+ + F+ D A +++P+SG+ AN V+ L + D+++ L HGGH+SH
Sbjct: 127 QKRALEAFRLDAAKWGVNVQPLSGSPANFHVYTALLKAHDRIMALDLPHGGHLSHGYQTD 186
Query: 127 FGAAGMRGLEVHTWPFD-NESFN-IDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAP 184
+ T P+ NES ID D+ EK PK++V G S + + +
Sbjct: 187 TKKISAVSIFFETMPYRLNESTGYIDYDQLEKSATLFRPKLIVAGASAYARLYDYARIRK 246
Query: 185 VAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADD 244
V + A ++ D AH+ GL+A G P + AD++T +THK+ GP+G +I ++K +
Sbjct: 247 VCDKQKAILLADMAHISGLVAAGVIPSPF-DYADVVTTTTHKSLRGPRGAMIFFRKGVKE 305
Query: 245 ----------ETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAKQIVKNA 292
+ K+ A+FPG+ H H + G + A EY +AY +Q++ N
Sbjct: 306 VNKQGKEVLYDYEDKINQAVFPGLQGGPHNHTITGLAVALKQATTAEY-KAYQEQVMSNC 364
Query: 293 KALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPW 352
AE L + G++++ G T++H V+V++ + G +LE I NKN +P
Sbjct: 365 AKFAETLVKSGYELV---SGGTENHLVLVNLKN-KGIDGSRVEKVLEAVHIAANKNTVPG 420
Query: 353 DPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAH 386
D V P G+R+G +T G +E++ ++A+
Sbjct: 421 DVSAMV--PGGIRMGTPALTSRGFVEEDFAKVAY 452
>gb|AAF34299.1| (AC021199) putative hydroxymethyltransferase; 49598-47322
[Arabidopsis thaliana]
Length = 578
Score = 181 bits (454), Expect = 2e-44
Identities = 133/410 (32%), Positives = 212/410 (51%), Gaps = 37/410 (9%)
Query: 8 DKVLHFIEEHEKWRS-HTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYV 66
D +H + E EK R I LIASEN +V A+ S +KY+EG P RYY G +Y+
Sbjct: 122 DPDIHELMEKEKQRQVRGIELIASENFVCRAVMEALGSHLTNKYSEGMPGARYYTGNQYI 181
Query: 67 DEVELIGVELFTKLF--KSDY--ADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHI 122
D++E + +E F +SD +++P S T+AN AV+ GL PG++++ L + GGH+
Sbjct: 182 DQIENLCIERALTAFGLESDKWGVNVQPYSCTSANFAVYTGLLLPGERIMGLDSPSGGHM 241
Query: 123 SH---MPFG---AAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFP 176
SH P G +A E + + ++ ID DK E + PKI++ GGS +P
Sbjct: 242 SHGYCTPGGKKISAASIFFESFPYKVNPQTGYIDYDKLEDKALDYRPKILICGGSSYPRD 301
Query: 177 HPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVI 236
+ +A + GA ++ D AH+ GL+A E +P + DI+T++THK GP+GG+I
Sbjct: 302 WDFARVRQIADKCGAVLMCDMAHISGLVATKECSNPF-DHCDIVTSTTHKGLRGPRGGII 360
Query: 237 LYKK------------FADDET----IAKLQWAIFPGVLSNHHLHHMAGKVITAAEML-- 278
Y++ D T K+ +A+FP + H +H+A I ++
Sbjct: 361 FYRRGPKIRKQGHHSSHCDTSTHYDLEEKINFAVFPSLQGGPHNNHIAALAIALKQVATP 420
Query: 279 EYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLL 338
EY +AY +Q+ KNA+ALA AL +++ G T +H ++ D++ + G + +
Sbjct: 421 EY-KAYIQQMKKNAQALAAALLRRKCRLV---TGGTDNHLLLWDLTPMGLTGKVY-EKVC 475
Query: 339 EEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFM 388
E I LNK + D P G+RIG MT G +E + + +A F+
Sbjct: 476 EMCHITLNKTAIFGD--NGTISPGGVRIGTPAMTTRGCIESDFETMADFL 523
>sp|O53441|GLA1_MYCTU SERINE HYDROXYMETHYLTRANSFERASE 1 (SERINE METHYLASE 1) (SHMT 1)
>gi|7433541|pir||C70896 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Mycobacterium tuberculosis (strain H37RV)
>gi|2896730|emb|CAA17209.1| (AL021897) glyA
[Mycobacterium tuberculosis]
Length = 426
Score = 180 bits (452), Expect = 3e-44
Identities = 124/377 (32%), Positives = 196/377 (51%), Gaps = 20/377 (5%)
Query: 24 TINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKS 83
T+ +IASEN +V +A S +KYAEG P +RYY GC++VD VE + + LF +
Sbjct: 26 TLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGA 85
Query: 84 DYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-MPFGAAGMRGLEVHTWPF 142
++A+++P SG AN AV L PG++++ L ++GGH++H M +G + E +
Sbjct: 86 EFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSG-KLYENGFYGV 144
Query: 143 DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLG 202
D + ID+D E PK+++ G S +P +A EVGA ++ D AH G
Sbjct: 145 DPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAG 204
Query: 203 LIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNH 262
L+A G P+ AD+++ + HKT G + G+I+ K+ + + A+FPG
Sbjct: 205 LVAAGLHPSPVPH-ADVVSTTVHKTLGGGRSGLIVGKQ----QYAKAINSAVFPGQQGGP 259
Query: 263 HLHHMAGKVIT--AAEMLEYGEAYAKQIVKNAKALAEAL-----AEEGFKVIGEDQGYTK 315
+H +AGK + A E+ + ++ + A+ +A+ L A+ G V+ G T
Sbjct: 260 LMHVIAGKAVALKIAATPEFADR-QRRTLSGARIIADRLMAPDVAKAGVSVV---SGGTD 315
Query: 316 SHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVG 375
H V+VD+ D P G A LL E GI +N+N +P DP + SGLRIG + G
Sbjct: 316 VHLVLVDLRD-SPLDGQAAEDLLHEVGITVNRNAVPNDPRPPM-VTSGLRIGTPALATRG 373
Query: 376 MMEDEMKEIAHFMKRVL 392
+ E E+A + L
Sbjct: 374 FGDTEFTEVADIIATAL 390
>emb|CAB72302.2| (AL138973) serine hydroxymethyltransferase [Leishmania major]
Length = 480
Score = 179 bits (450), Expect = 5e-44
Identities = 128/416 (30%), Positives = 207/416 (48%), Gaps = 26/416 (6%)
Query: 1 MAYKEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYY 60
++ +++ +V I+ + + + LIASEN TS +V + S +KYAEG P RYY
Sbjct: 28 ISLRDHDPEVHQLIQREMRRQIEGLELIASENFTSRAVLDCLGSVLTNKYAEGLPGNRYY 87
Query: 61 QGCKYVDEVELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHT 116
G + VDE+E + V F D A ++P SG+ AN AV+ L +P D+++ L
Sbjct: 88 GGTEVVDELENLCVRRARAAFCLDAALWGVSVQPYSGSPANLAVYTALLRPHDRMMGLSL 147
Query: 117 SHGGHISHMPFGAAGMRGLEVHTWPFDNESFNI------DVDKAEKMIRELEPKIVVFGG 170
GGH++H + A + L + F++ ++I D D+ + +P++++ GG
Sbjct: 148 QAGGHLTHGFYTAT--KRLSASSIFFESLPYSITPKGLVDYDQLAYLADIYKPRLIIAGG 205
Query: 171 SLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPG 230
S +P K + VGA+ + D +H GL+A E DP E AD++T +THKT G
Sbjct: 206 SAYPRDWDYKRYREICDSVGAYFMVDMSHFSGLVAAREHNDPF-EYADVVTTTTHKTLRG 264
Query: 231 PQGGVILYKKFADD--ETIA---KLQWAIFPGVLSNHHLHHMAGKVITAAEMLE-YGEAY 284
P+ G+I +KK E + + A+FP + HLH +AG E+ Y
Sbjct: 265 PRSGMIFFKKSIKQGKENVCVEDSINNAVFPALQGGPHLHQIAGIATQLKEVASPEWRTY 324
Query: 285 AKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGII 344
KQ+ NA+ALA L E G ++ G T +H ++ ++ H G LL+ I
Sbjct: 325 IKQVKANARALAAVLTEGGETLV---SGGTDNHLLLWNLRP-HGLTGSKLEKLLDMVNIT 380
Query: 345 LNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR-VLLDKEDPK 399
+NKN + D P G+R+G +T G+ E++ + + + R V L KE K
Sbjct: 381 VNKNTIFGD--RSAQAPYGIRLGTPALTTRGLQEEDFRRVGQLLIRSVQLSKEVQK 434
>pdb|1EJI|A Chain A, Recombinant Serine Hydroxymethyltransferase (Mouse)
>gi|11514069|pdb|1EJI|B Chain B, Recombinant Serine
Hydroxymethyltransferase (Mouse) >gi|11514070|pdb|1EJI|C
Chain C, Recombinant Serine Hydroxymethyltransferase
(Mouse) >gi|11514071|pdb|1EJI|D Chain D, Recombinant
Serine Hydroxymethyltransferase (Mouse)
Length = 478
Score = 179 bits (449), Expect = 6e-44
Identities = 124/409 (30%), Positives = 207/409 (50%), Gaps = 30/409 (7%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
K+ +V I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G
Sbjct: 21 KDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSSLNNKYSEGYPGQRYYGGT 80
Query: 64 KYVDEVELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+++DE+E + + + + D +++P SG+ AN AV+ L +P ++ L G
Sbjct: 81 EFIDELEXLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIXGLDLPDG 140
Query: 120 GHISH-----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFP 174
GH++H +A E + E+ I+ D+ E+ PK+++ G S +
Sbjct: 141 GHLTHGFXTDKKKISATSIFFESXPYKVYPETGYINYDQLEENASLFHPKLIIAGTSCYS 200
Query: 175 FPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGG 234
L +A + GA++ D AH+ GL+A G P E ++T +THKT G + G
Sbjct: 201 RNLDYARLRKIADDNGAYLXADXAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGCRAG 259
Query: 235 VILYKK-------FADDETIAKLQ----WAIFPGVLSNHHLHHMAGKVIT--AAEMLEYG 281
I Y+K ET +L+ A+FPG+ H H +AG + A E+
Sbjct: 260 XIFYRKGVRSVDPKTGKETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAXTTEF- 318
Query: 282 EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEA 341
+ Y Q++ N +AL++AL E G+K++ G + +H ++ D+ GG A +LE
Sbjct: 319 KIYQLQVLANCRALSDALTELGYKIV---TGGSDNHLILXDLRS-KGTDGGRAEKVLEAC 374
Query: 342 GIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
I NKN P D + PSGLR+G +T G++E++ +++AHF+ R
Sbjct: 375 SIACNKNTCPGD--KSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHR 421
>sp|O13972|GLY2_SCHPO PROBABLE SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|7493373|pir||T38353 serine hydroxymethyltransferase
- fission yeast (Schizosaccharomyces pombe)
>gi|2330795|emb|CAB11269.1| (Z98601) serine
hydroxymethyltransferase [Schizosaccharomyces pombe]
Length = 467
Score = 178 bits (446), Expect = 1e-43
Identities = 132/425 (31%), Positives = 204/425 (47%), Gaps = 37/425 (8%)
Query: 7 RDKVLHFIEEHEKWRSHT-INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKY 65
+D + I HE R + + LIASEN TS +V A+ S +KY+EG+P RYY G K+
Sbjct: 15 QDPTVAEIMRHEADRQRSSVVLIASENFTSRAVMDALGSVMSNKYSEGYPGARYYGGNKF 74
Query: 66 VDEVELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGH 121
+D++E + E F D A +++ +SG+ AN V+ + P +++ L GGH
Sbjct: 75 IDQIETLCQERALAAFNLDPAKWGVNVQCLSGSPANMQVYQAIMPPHGRLMGLDLPSGGH 134
Query: 122 ISH-----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFP 176
+SH +A E + D + ID D E + PKI+V G S +
Sbjct: 135 LSHGYQTDTKKISAVSTYFESMPYRVDPNTGLIDYDMLEHDAQLFRPKILVAGTSAYCRL 194
Query: 177 HPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVI 236
+ +A V A++V D AH+ GL++ G P E AD++T +THK+ GP+G +I
Sbjct: 195 IDYARMRQIADSVNAYLVVDMAHISGLVSAGVIPSPF-EYADVVTTTTHKSLRGPRGAMI 253
Query: 237 LYKK------------FADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EA 283
+++ + D E K+ +++FPG H H + + + E +
Sbjct: 254 FFRRGLRKHDKKGNPIYYDLED--KINFSVFPGHQGGPHNHTITALAVALKQCQEPAYKE 311
Query: 284 YAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGI 343
Y Q+VKNAK E + G+K+ + T SH V+VDV G A +LE I
Sbjct: 312 YQAQVVKNAKVCEEEFKKRGYKLAADG---TDSHMVLVDVKS-KGVDGARAERVLELINI 367
Query: 344 ILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL-----LDKEDP 398
+ NKN +P D + PSG+R+G MT G E + + ++ R L L KE P
Sbjct: 368 VTNKNTVPSD--KSAFSPSGIRVGTPAMTTRGFKEQDFVRVVDYIDRALTFAANLQKELP 425
Query: 399 KKVRK 403
K K
Sbjct: 426 KDANK 430
>gb|AAA21023.1| (L22529) serine hydroxymethyltransferase [Saccharomyces cerevisiae]
Length = 469
Score = 174 bits (436), Expect = 2e-42
Identities = 129/415 (31%), Positives = 214/415 (51%), Gaps = 33/415 (7%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
I++ + + H+I+LIASEN TS SV A+ + +KY+EG+P RYY G +++D +E++
Sbjct: 28 IKDEIERQKHSIDLIASENFTSTSVFDALGTPLSNKYSEGYPGARYYGGNEHIDRMEILC 87
Query: 74 VELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGA 129
+ K F +++ +SG+ AN V+ + +P ++++ L+ GGH+SH +
Sbjct: 88 QQRALKAFHVTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLYLPDGGHLSH-GYAT 146
Query: 130 AGMRGLEVHTW----PF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELA 183
+ V T+ P+ + E+ ID D EK PK++V G S + K +
Sbjct: 147 ENRKISAVSTYFESFPYRVNPETGIIDYDTLEKNAILYRPKVLVAGTSAYCRLIDYKRMR 206
Query: 184 PVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK--- 240
+A + GA+++ D AH+ GLIA G P E ADI+T +THK+ GP+G +I +++
Sbjct: 207 EIADKCGAYLMVDMAHISGLIAAGVIPSPF-EYADIVTTTTHKSLRGPRGAMIFFRRGVR 265
Query: 241 ----FADDETIAKLQ----WAIFPGVLSNHHLHHMA--GKVITAAEMLEYGEAYAKQIVK 290
E + L+ +++FPG H H +A + A E+ E Y Q++K
Sbjct: 266 SINPKTGKEVLYDLENPINFSVFPGHQGGPHNHTIAALATALKQAATPEFKE-YQTQVLK 324
Query: 291 NAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLL 350
NAKAL G++++ T SH V+V + + G + E+ I LNKN +
Sbjct: 325 NAKALESEFKNLGYRLVSNG---TDSHMVLVSLRE-KGVDGARVEYICEKINIALNKNSI 380
Query: 351 PWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFM-KRVLLDKEDPKKVRKD 404
P D V P G+RIG MT GM E++ I ++ K V ++ +K+ KD
Sbjct: 381 PGDKSALV--PGGVRIGAPAMTTRGMGEEDFHRIVQYINKAVEFAQQVQQKLPKD 433
>gb|AAA36018.1| (L23928) serine hydroxymethyltransferase [Homo sapiens]
Length = 444
Score = 173 bits (435), Expect = 3e-42
Identities = 120/391 (30%), Positives = 198/391 (49%), Gaps = 43/391 (10%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 32 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 91
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E + + + +K D +++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 92 LETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 151
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R PK+++ G S +
Sbjct: 152 GFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEY 211
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A E GA+++ D AH+ GL+A G P E ++T +THKT G + G+I Y+
Sbjct: 212 ARLRKIADENGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGCRAGMIFYR 270
Query: 240 KFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEAYAKQIVKNAKALAEAL 299
K GV + A LE+ + Y Q+V N +AL+EAL
Sbjct: 271 K----------------GV----------AVALKQAMTLEF-KVYQHQVVANCRALSEAL 303
Query: 300 AEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVN 359
E G+K++ G + +H ++VD+ GG A +LE I NKN P D
Sbjct: 304 TELGYKIV---TGGSDNHLILVDLRS-KGTDGGRAEKVLEACSIACNKNTCPGD--RSAL 357
Query: 360 EPSGLRIGVQEMTRVGMMEDEMKEIAHFMKR 390
PSGLR+G +T G++E + +++AHF+ R
Sbjct: 358 RPSGLRLGTPALTSRGLLEKDFQKVAHFIHR 388
>sp|O13425|GLYM_CANAL SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|2282056|gb|AAB64196.1| (AF009965) serine
hydroxymethyl-transferase I [Candida albicans]
Length = 493
Score = 173 bits (434), Expect = 4e-42
Identities = 119/410 (29%), Positives = 204/410 (49%), Gaps = 32/410 (7%)
Query: 21 RSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKL 80
+ ++I LI SEN TS +V + S +KY+EG+P +RYY G + +D+ E + + +
Sbjct: 57 QKNSITLIPSENFTSKAVMDLLGSEMQNKYSEGYPGERYYGGNEIIDKAEALCQKRALEA 116
Query: 81 FKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH---MPFGAAGMR 133
F D + +++P+SG AN + + + GD+++ L HGGH+SH
Sbjct: 117 FGLDPSQWGVNVQPLSGAPANLYAYSAILEVGDRIMGLDLPHGGHLSHGYQTKTTKISYI 176
Query: 134 GLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGA 191
T P+ + E+ ID D EK + PK++V G S + K + ++ +GA
Sbjct: 177 SKYFQTMPYRLNEETGIIDYDTLEKNAQLFRPKVIVAGASAYSRVIDYKRMRQLSIRLGA 236
Query: 192 FVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETI---- 247
+++ D AH+ GL++ P +DI+T +THK+ GP+G +I ++K T
Sbjct: 237 YLLSDMAHISGLVSAVVTDSPF-PYSDIVTTTTHKSLRGPRGAMIFFRKGIRKVTTKGKE 295
Query: 248 ------AKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEA-YAKQIVKNAKALAEALA 300
K+ + +FPG H H ++ + + E Y +++V NAK A+AL
Sbjct: 296 IPYELERKINFLVFPGHQGGPHNHTISALAVALKQCTEPEYVKYQQEVVSNAKHFADALV 355
Query: 301 EEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNE 360
+GFK++ + T +H ++VD+ + G +LE A I NKN +P D
Sbjct: 356 SKGFKLVSDG---TDTHLILVDLRSRN-IDGARVEAVLERANIAANKNTVPGD--VSALF 409
Query: 361 PSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL-----LDKEDPKKVRKDV 405
PSGLR+G MT G +E ++A F+ + + L ++ KV K++
Sbjct: 410 PSGLRVGTPAMTTRGFGPEEFDKVAEFIDQAVNIAIELKAQEQGKVPKEL 459
>gi|6323087 serine hydroxymethyltransferase; Shm2p [Saccharomyces cerevisiae]
>gi|1707995|sp|P37291|GLYC_YEAST SERINE
HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|2117695|pir||S61632 glycine hydroxymethyltransferase
(EC 2.1.2.1), cytosolic - yeast (Saccharomyces
cerevisiae) >gi|1181279|emb|CAA64305.1| (X94607) glycine
hydroxymethyltransferase [Saccharomyces cerevisiae]
>gi|1360402|emb|CAA97588.1| (Z73230) ORF YLR058c
[Saccharomyces cerevisiae]
Length = 469
Score = 173 bits (433), Expect = 5e-42
Identities = 124/402 (30%), Positives = 207/402 (50%), Gaps = 32/402 (7%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
I++ + + H+I+LIASEN TS SV A+ + +KY+EG+P RYY G +++D +E++
Sbjct: 28 IKDEIERQKHSIDLIASENFTSTSVFDALGTPLSNKYSEGYPGARYYGGNEHIDRMEILC 87
Query: 74 VELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFGA 129
+ K F +++ +SG+ AN V+ + +P ++++ L+ GGH+SH +
Sbjct: 88 QQRALKAFHVTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLYLPDGGHLSH-GYAT 146
Query: 130 AGMRGLEVHTW----PF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELA 183
+ V T+ P+ + E+ ID D EK PK++V G S + K +
Sbjct: 147 ENRKISAVSTYFESFPYRVNPETGIIDYDTLEKNAILYRPKVLVAGTSAYCRLIDYKRMR 206
Query: 184 PVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK--- 240
+A + GA+++ D AH+ GLIA G P E ADI+T +THK+ GP+G +I +++
Sbjct: 207 EIADKCGAYLMVDMAHISGLIAAGVIPSPF-EYADIVTTTTHKSLRGPRGAMIFFRRGVR 265
Query: 241 ----FADDETIAKLQ----WAIFPGVLSNHHLHHMA--GKVITAAEMLEYGEAYAKQIVK 290
E + L+ +++FPG H H +A + A E+ E Y Q++K
Sbjct: 266 SINPKTGKEVLYDLENPINFSVFPGHQGGPHNHTIAALATALKQAATPEFKE-YQTQVLK 324
Query: 291 NAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLL 350
NAKAL G++++ T SH V+V + + G + E+ I LNKN +
Sbjct: 325 NAKALESEFKNLGYRLVSNG---TDSHMVLVSLRE-KGVDGARVEYICEKINIALNKNSI 380
Query: 351 PWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
P D V P G+RIG MT GM E++ I ++ + +
Sbjct: 381 PGDKSALV--PGGVRIGAPAMTTRGMGEEDFHRIVQYINKAV 420
>sp|P34898|GLYC_NEUCR SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|539387|pir||A42241 glycine hydroxymethyltransferase
(EC 2.1.2.1), cytosolic - Neurospora crassa
>gi|7545109|gb|AAA31967.2| (M81918) serine
hydroxymethyltransferase [Neurospora crassa]
Length = 479
Score = 172 bits (432), Expect = 6e-42
Identities = 134/420 (31%), Positives = 215/420 (50%), Gaps = 34/420 (8%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V +++ + + +I LIASEN+TS +V A+ S +KY+EG P RYY G +++DE
Sbjct: 24 QVAEIMKKEVQRQRESIILIASENVTSRAVFDALGSPMSNKYSEGLPGARYYGGNQHIDE 83
Query: 69 VELI----GVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E++ +E F K +++ +SG+ AN V+ + +++ L HGGH+SH
Sbjct: 84 IEVLCQNRALEAFHLDPKQWGVNVQCLSGSPANLQVYQAIMPVHGRLMGLDLPHGGHLSH 143
Query: 125 ---MPFGAAGMRGLEVHTWPF--DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
P T P+ + ++ ID D EK + PK++V G S +
Sbjct: 144 GYQTPQRKISAVSTYFETMPYRVNIDTGLIDYDTLEKNAQLFRPKVLVAGTSAYCRLIDY 203
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
+ + +A VGA++V D AH+ GLIA P AD++T +THK+ GP+G +I ++
Sbjct: 204 ERMRKIADSVGAYLVVDMAHISGLIASEVIPSPFLY-ADVVTTTTHKSLRGPRGAMIFFR 262
Query: 240 --KFADDET--------IAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAKQ 287
+ D +T K+ +++FPG H H + + A E+ E Y ++
Sbjct: 263 GVRSVDAKTGKETLYDLEDKINFSVFPGHQGGPHNHTITALAVALKQAASPEFKE-YQQK 321
Query: 288 IVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIIL 345
+V NAKAL + L E G+K++ + T SH V+V DL P G G LLE+ I
Sbjct: 322 VVANAKALEKKLKELGYKLVSDG---TDSHMVLV---DLRPIGVDGARVEFLLEQINITC 375
Query: 346 NKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFM-KRVLLDKEDPKKVRKD 404
NKN +P D + P GLRIG MT G E + +++A F+ + V L KE + K+
Sbjct: 376 NKNAVPGD--KSALTPGGLRIGTPAMTSRGFGEADFEKVAVFVDEAVKLCKEIQASLPKE 433
>gi|6319739 Serine hydroxymethyltransferase, mitochondrial; Shm1p
[Saccharomyces cerevisiae] >gi|419894|pir||S29348
glycine hydroxymethyltransferase (EC 2.1.2.1) precursor,
mitochondrial - yeast (Saccharomyces cerevisiae)
>gi|296561|emb|CAA49927.1| (X70529) ORF YBR1732
[Saccharomyces cerevisiae] >gi|536692|emb|CAA85226.1|
(Z36131) ORF YBR263w [Saccharomyces cerevisiae]
Length = 565
Score = 170 bits (427), Expect = 2e-41
Identities = 113/405 (27%), Positives = 201/405 (48%), Gaps = 36/405 (8%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
++ +++ + H+I LI SEN TS +V + S +KY+EG+P +RYY G + +D+
Sbjct: 114 EMFDILQQERHRQKHSITLIPSENFTSKAVMDLLGSELQNKYSEGYPGERYYGGNEIIDK 173
Query: 69 VELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
E + +L+ D A +++P+SG AN V+ + G++++ L GGH+SH
Sbjct: 174 SESLCQARALELYGLDPAKWGVNVQPLSGAPANLYVYSAIMNVGERLMGLDLPDGGHLSH 233
Query: 125 ---------MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPF 175
+ F + + + H D+ + ID D + + + PK++V G S +
Sbjct: 234 GYQLKSGTPISFISKYFQSMPYHV---DHTTGLIDYDNLQVLAKAFRPKVIVAGTSAYSR 290
Query: 176 PHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGV 235
+++ GA+++ D AH+ GL+A P E +DI+T +THK+ GP+G +
Sbjct: 291 LIDYARFKEISQGCGAYLMSDMAHISGLVAANVVPSPF-EHSDIVTTTTHKSLRGPRGAM 349
Query: 236 ILYKKFADD----------ETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEML--EYGEA 283
I ++K E K+ +++FPG H H + + + + E+ E
Sbjct: 350 IFFRKGIKSVTKKGKEIPYELEKKINFSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKE- 408
Query: 284 YAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGI 343
Y ++IV N+K A+ L + G+K++ G T +H +++D+S G +L I
Sbjct: 409 YQQKIVDNSKWFAQELTKMGYKLV---SGGTDNHLIVIDLSGTQ-VDGARVETILSALNI 464
Query: 344 ILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFM 388
NKN +P D + PSGLRIG MT G +E ++A ++
Sbjct: 465 AANKNTIPGD--KSALFPSGLRIGTPAMTTRGFGREEFSQVAKYI 507
>pir||B46746 glycine hydroxymethyltransferase (EC 2.1.2.1) precursor,
mitochondrial - human (fragment)
>gi|703093|gb|AAA63258.1| (L11932) serine
hydroxymethyltransferase [Homo sapiens]
Length = 474
Score = 170 bits (427), Expect = 2e-41
Identities = 121/387 (31%), Positives = 192/387 (49%), Gaps = 32/387 (8%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN S + A+ S +KY+EG+P +RYY G + VDE+EL+ + F D
Sbjct: 41 LELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLD 100
Query: 85 YA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFG-----AAGMRGL 135
A +++P SG+ AN AV+ L QP D+++ L GGH++H +A
Sbjct: 101 PAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFF 160
Query: 136 EVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVY 195
E + + ++ ID ++ R P++++ G S + + V EV A ++
Sbjct: 161 ESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLA 220
Query: 196 DAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK---KFADDET------ 246
D AH+ GL+A P + ADI+T +THKT G + G+I Y+ K D +T
Sbjct: 221 DMAHISGLVAAKVIPSPFKH-ADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREILY 279
Query: 247 --IAKLQWAIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQIVKNAKALAEALAEEG 303
++ +A+FP + H H +A + + Y+ Q++KNA+A+A+AL E G
Sbjct: 280 TFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG 339
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEP 361
+ ++ G T +H V+V DL P G G A +LE I NKN P D P
Sbjct: 340 YSLV---SGGTDNHLVLV---DLRPKGLDGARAERVLELVSITANKNTCPGD--RSAITP 391
Query: 362 SGLRIGVQEMTRVGMMEDEMKEIAHFM 388
GLR+G +T ED+ + + F+
Sbjct: 392 GGLRLGAPALTSRQFREDDFRRVVDFI 418
>gi|4885595 serine hydroxymethyltransferase 2 (mitochondrial) [Homo sapiens]
>gi|746436|gb|AAA64572.1| (U23143) mitochondrial serine
hydroxymethyltransferase [Homo sapiens]
Length = 483
Score = 170 bits (427), Expect = 2e-41
Identities = 121/387 (31%), Positives = 192/387 (49%), Gaps = 32/387 (8%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN S + A+ S +KY+EG+P +RYY G + VDE+EL+ + F D
Sbjct: 50 LELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLD 109
Query: 85 YA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFG-----AAGMRGL 135
A +++P SG+ AN AV+ L QP D+++ L GGH++H +A
Sbjct: 110 PAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFF 169
Query: 136 EVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVY 195
E + + ++ ID ++ R P++++ G S + + V EV A ++
Sbjct: 170 ESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLA 229
Query: 196 DAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK---KFADDET------ 246
D AH+ GL+A P + ADI+T +THKT G + G+I Y+ K D +T
Sbjct: 230 DMAHISGLVAAKVIPSPFKH-ADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPY 288
Query: 247 --IAKLQWAIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQIVKNAKALAEALAEEG 303
++ +A+FP + H H +A + + Y+ Q++KNA+A+A+AL E G
Sbjct: 289 TFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG 348
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEP 361
+ ++ G T +H V+V DL P G G A +LE I NKN P D P
Sbjct: 349 YSLV---SGGTDNHLVLV---DLRPKGLDGARAERVLELVSITANKNTCPGD--RSAITP 400
Query: 362 SGLRIGVQEMTRVGMMEDEMKEIAHFM 388
GLR+G +T ED+ + + F+
Sbjct: 401 GGLRLGAPALTSRQFREDDFRRVVDFI 427
>sp|P34897|GLYM_HUMAN SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
Length = 504
Score = 170 bits (427), Expect = 2e-41
Identities = 121/387 (31%), Positives = 192/387 (49%), Gaps = 32/387 (8%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN S + A+ S +KY+EG+P +RYY G + VDE+EL+ + F D
Sbjct: 71 LELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLD 130
Query: 85 YA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISHMPFG-----AAGMRGL 135
A +++P SG+ AN AV+ L QP D+++ L GGH++H +A
Sbjct: 131 PAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFF 190
Query: 136 EVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVY 195
E + + ++ ID ++ R P++++ G S + + V EV A ++
Sbjct: 191 ESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLA 250
Query: 196 DAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK---KFADDET------ 246
D AH+ GL+A P + ADI+T +THKT G + G+I Y+ K D +T
Sbjct: 251 DMAHISGLVAAKVIPSPFKH-ADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPY 309
Query: 247 --IAKLQWAIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQIVKNAKALAEALAEEG 303
++ +A+FP + H H +A + + Y+ Q++KNA+A+A+AL E G
Sbjct: 310 TFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG 369
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEP 361
+ ++ G T +H V+V DL P G G A +LE I NKN P D P
Sbjct: 370 YSLV---SGGTDNHLVLV---DLRPKGLDGARAERVLELVSITANKNTCPGD--RSAITP 421
Query: 362 SGLRIGVQEMTRVGMMEDEMKEIAHFM 388
GLR+G +T ED+ + + F+
Sbjct: 422 GGLRLGAPALTSRQFREDDFRRVVDFI 448
>sp|O83349|GLYA_TREPA SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433537|pir||G71336 glycine hydroxymethyltransferase
(EC 2.1.2.1) - syphilis spirochete
>gi|3322607|gb|AAC65317.1| (AE001213) serine
hydroxymethyltransferase (glyA) [Treponema pallidum]
Length = 574
Score = 170 bits (426), Expect = 3e-41
Identities = 142/438 (32%), Positives = 210/438 (47%), Gaps = 61/438 (13%)
Query: 1 MAYKEYRDKVLH--------FIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAE 52
+AY D V H ++E RS+ + LIASEN +S +V A+A+ KYAE
Sbjct: 23 VAYLANLDLVAHQFPQIASDIVQELIDQRSY-VKLIASENYSSLAVQAAMANLLTDKYAE 81
Query: 53 GWPRQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGL-------- 104
G+P RYY GC+ VD +E LF +++A ++P SG +AN F+ +
Sbjct: 82 GFPHHRYYGGCQNVDSIESAAAAEACALFGAEHAYVQPHSGADANLVAFWAILSRQIEMP 141
Query: 105 -----------------------GQPGDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWP 141
K++ L GGH++H R V ++
Sbjct: 142 TLSSLGVTAATHLSEEQWEVLRQKMGNQKLMGLDYFSGGHLTHGYRQNVSGRMFRVVSYA 201
Query: 142 FDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVL 201
D ++ +D E + P I++ G S +P + +A +VGA ++ D AH
Sbjct: 202 VDRDTGLLDYAAIEAQAKRERPLILLAGYSAYPRSINFRIFREIADKVGAVLMADMAHFA 261
Query: 202 GLIAGGEF---QDPLREGADIMTASTHKTFPGPQGGVILYKK-FADDETIAKLQWAIFPG 257
GL+AGG F +DP+R + I+T++THKT GP+G IL KK FA E + K P
Sbjct: 262 GLVAGGVFTGDEDPVR-WSHIVTSTTHKTLRGPRGAFILCKKEFA--EAVDK----GCPL 314
Query: 258 VLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKS 316
VL H MA K + E + YA + NA+ALA+A ++G ++ G T +
Sbjct: 315 VLGGPLPHVMAAKAVAFREARNAAFKTYAHAVRDNARALADACIQQGMQL---QTGGTDN 371
Query: 317 HQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRV 374
H +++DV P G G A L + G+ LN+N LP+DP SGLRIG +T +
Sbjct: 372 HLLLLDV---RPFGLTGRQAERALIDCGVTLNRNSLPFDP-NGAWLTSGLRIGTPAVTSL 427
Query: 375 GMMEDEMKEIAHFMKRVL 392
GM +EMK IA + RVL
Sbjct: 428 GMGPEEMKRIARLIARVL 445
>gb|AAF07198.1|AF195023_1 (AF195023) SHMT [Plasmodium falciparum]
Length = 442
Score = 169 bits (425), Expect = 4e-41
Identities = 114/417 (27%), Positives = 207/417 (49%), Gaps = 19/417 (4%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
++Y ++ +E+ + + TINLIASEN+T+ +V + +KY+EG+P +RYY G
Sbjct: 8 QKYDKELFDLLEKEKNRQIETINLIASENLTNTAVRECLGDRISNKYSEGYPHKRYYGGN 67
Query: 64 KYVDEVELI----GVELFTKLFKSDYADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
YVD++E + +E F + +++P+SG+ AN + L K++ +H G
Sbjct: 68 DYVDKIEELCYKRALEAFNVSEEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSG 127
Query: 120 GHISHMPFGAAGMRGL-----EVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFP 174
GH++H F + E + ++E + +D++ + +PK+++ G + +P
Sbjct: 128 GHLTHGFFDEKKKVSITSDLFESKLYKCNSEGY-VDMESVRNLALSFQPKVIICGYTSYP 186
Query: 175 FPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGG 234
K + EV A++ D +H+ +A +P AD++T +THK GP+
Sbjct: 187 RDIDYKGFREICDEVNAYLFADISHISSFVACNLLNNPFTY-ADVVTTTTHKILRGPRSA 245
Query: 235 VILYKKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEM-LEYGEAYAKQIVKNAK 293
+I + K + K+ ++FP H + +A E+ + + Y KQ++ N+K
Sbjct: 246 LIFFNKKRNPGIDQKINSSVFPSFQGGPHNNKIAAVACQLKEVNTPFFKEYTKQVLLNSK 305
Query: 294 ALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWD 353
ALAE L + ++ T +H ++VD+ + G I LNKN +P D
Sbjct: 306 ALAECLLKRNLDLVTNG---TDNHLIVVDLRKYNITGSK-LQETCNAINIALNKNTIPSD 361
Query: 354 PLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAH-FMKRVLLDKEDPKKVRKDVYYFR 409
++ V+ PSG+RIG +T G E +M+ IA +K +LL E +K K + F+
Sbjct: 362 -VDCVS-PSGIRIGTPALTTRGCKEKDMEFIADMLLKAILLTDELQQKYGKKLVDFK 416
>pir||A33696 glycine hydroxymethyltransferase (EC 2.1.2.1), mitochondrial -
rabbit
Length = 475
Score = 169 bits (424), Expect = 5e-41
Identities = 119/387 (30%), Positives = 192/387 (48%), Gaps = 32/387 (8%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN S + A+ S +KY+EG+P +RYY G + VDE+EL+ + F D
Sbjct: 42 LELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLD 101
Query: 85 YA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-----MPFGAAGMRGL 135
A +++P SG+ AN A + L QP D+++ L GGH++H + +A
Sbjct: 102 PAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRVSATSIFF 161
Query: 136 EVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVY 195
E + + ++ ID ++ R P++++ G S + + V EV A ++
Sbjct: 162 ESMPYKLNPQTGLIDYEQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLA 221
Query: 196 DAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK---FADDET------ 246
D AH+ GL+A P + AD++T +THKT G + G+I Y+K D +T
Sbjct: 222 DMAHISGLVAAKVIPSPFKH-ADVVTTTTHKTLRGARSGLIFYRKGVRTVDPKTGQEIPY 280
Query: 247 --IAKLQWAIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQIVKNAKALAEALAEEG 303
++ +A+FP + H H +A + + Y+ Q++KNA+A+A+AL E G
Sbjct: 281 TFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG 340
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEP 361
+ ++ G T +H V+V DL P G G A +LE I NKN P D P
Sbjct: 341 YSLV---SGGTDNHLVLV---DLRPKGLDGARAERVLELVSITANKNTCPGD--RSAITP 392
Query: 362 SGLRIGVQEMTRVGMMEDEMKEIAHFM 388
GLR+G +T ED+ + + F+
Sbjct: 393 GGLRLGAPALTSRQFREDDFRRVVDFI 419
>sp|P37292|GLYM_YEAST SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|408368|gb|AAA21024.1| (L22528) serine
hydroxymethyltransferase [Saccharomyces cerevisiae]
Length = 490
Score = 169 bits (424), Expect = 5e-41
Identities = 113/405 (27%), Positives = 200/405 (48%), Gaps = 36/405 (8%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
++ +++ + H+I LI SEN TS +V S +KY+EG+P +RYY G + +D+
Sbjct: 39 EMFDILQQERHRQKHSITLIPSENFTSKAVMDLSGSELQNKYSEGYPGERYYGGNEIIDK 98
Query: 69 VELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
E + +L+ D A +++P+SG AN V+ + G++++ L GGH+SH
Sbjct: 99 SESLCQARALELYGLDPAKWGVNVQPLSGAPANLYVYSAIMNVGERLMGLDLPDGGHLSH 158
Query: 125 ---------MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPF 175
+ F + + + H D+ + ID D + + + PK++V G S +
Sbjct: 159 GYQLKSGTPISFISKYFQSMPYHV---DHTTGLIDYDNLQVLAKAFRPKVIVAGTSAYSR 215
Query: 176 PHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGV 235
+++ GA+++ D AH+ GL+A P E +DI+T +THK+ GP+G +
Sbjct: 216 LIDYARFKEISQGCGAYLMSDMAHISGLVAANVVPSPF-EHSDIVTTTTHKSLRGPRGAM 274
Query: 236 ILYKKFADD----------ETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEML--EYGEA 283
I ++K E K+ +++FPG H H + + + + E+ E
Sbjct: 275 IFFRKGIKSVTKKGKEIPYELEKKINFSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKE- 333
Query: 284 YAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGI 343
Y ++IV N+K A+ L + G+K++ G T +H +++D+S G +L I
Sbjct: 334 YQQKIVDNSKWFAQELTKMGYKLV---SGGTDNHLIVIDLSGTQ-VDGARVETILSALNI 389
Query: 344 ILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFM 388
NKN +P D + PSGLRIG MT G +E ++A ++
Sbjct: 390 AANKNTIPGD--KSALFPSGLRIGTPAMTTRGFGREEFSQVAKYI 432
>emb|CAB89056.1| (AL353872) serine hydroxymethyltransferase [Streptomyces coelicolor
A3(2)]
Length = 481
Score = 169 bits (423), Expect = 7e-41
Identities = 130/408 (31%), Positives = 198/408 (47%), Gaps = 47/408 (11%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN SP+ A+ + F KYAEG +R+Y GC+ VD VE + E +LF +
Sbjct: 41 LKLIASENYASPATLLAMGNWFSDKYAEGTIGRRFYAGCRNVDTVESLAAEHARELFGAR 100
Query: 85 YADLRPISGTNANQAVFF---------------GLGQPGD----------------KVIV 113
+A ++P SG +AN F+ G Q D +++
Sbjct: 101 HAYVQPHSGIDANLVAFWAVLGARVEVPFLEKTGARQVNDLTDADWAELRQAFGNQRMLG 160
Query: 114 LHTSHGGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLF 173
+ GGH++H + + ++ D + ID + RE +P I+V G S +
Sbjct: 161 MSLDAGGHLTHGFRPNISGKMFDQRSYGTDPATGLIDYEALRASAREFKPLIIVAGYSAY 220
Query: 174 PFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAG----GEFQDPLREGADIMTASTHKTFP 229
P + + +A EVGA ++ D AH GL+AG G+F DP+ A I+T +THK+
Sbjct: 221 PRLVNFRIMREIADEVGATLMVDMAHFAGLVAGKVLTGDF-DPVPH-AQIVTTTTHKSLR 278
Query: 230 GPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQI 288
GP+GG++L D+ P VL H MA K + AE + YA++I
Sbjct: 279 GPRGGMVLCDDSLKDQVDRGC-----PMVLGGPLPHVMAAKAVALAEARRPAFQDYAQRI 333
Query: 289 VKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKN 348
V NA+ALAE L + G ++ G T +H ++DV+ + G A L ++GI+ N+N
Sbjct: 334 VDNARALAEGLTKRGATLV---TGGTDNHLNLIDVASSYGLTGRQAEAALLDSGIVTNRN 390
Query: 349 LLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLLDKE 396
+P DP SG+RIG +T G+ EM E+A + RVL E
Sbjct: 391 AIPADP-NGAWYTSGIRIGTPALTTRGLGTAEMDEVAGLIDRVLTATE 437
>sp|P14519|GLYM_RABIT SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (SERINE
METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|1848137|emb|CAA62998.1| (X91902) serine
hydroxymethyltransferase [Oryctolagus cuniculus]
Length = 504
Score = 167 bits (418), Expect = 3e-40
Identities = 118/387 (30%), Positives = 191/387 (48%), Gaps = 32/387 (8%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN + A+ S +KY+EG+P +RYY G + VDE+EL+ + F D
Sbjct: 71 LELIASENFCIRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLD 130
Query: 85 YA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH-----MPFGAAGMRGL 135
A +++P SG+ AN A + L QP D+++ L GGH++H + +A
Sbjct: 131 PAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRVSATSIFF 190
Query: 136 EVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVY 195
E + + ++ ID ++ R P++++ G S + + V EV A ++
Sbjct: 191 ESMPYKLNPQTGLIDYEQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLA 250
Query: 196 DAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYKK---FADDET------ 246
D AH+ GL+A P + AD++T +THKT G + G+I Y+K D +T
Sbjct: 251 DMAHISGLVAAKVIPSPFKH-ADVVTTTTHKTLRGARSGLIFYRKGVRTVDPKTGQEIPY 309
Query: 247 --IAKLQWAIFPGVLSNHHLHHMAGKVITAAE-MLEYGEAYAKQIVKNAKALAEALAEEG 303
++ +A+FP + H H +A + + Y+ Q++KNA+A+A+AL E G
Sbjct: 310 TFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG 369
Query: 304 FKVIGEDQGYTKSHQVIVDVSDLHPAG--GGWAAPLLEEAGIILNKNLLPWDPLEKVNEP 361
+ ++ G T +H V+V DL P G G A +LE I NKN P D P
Sbjct: 370 YSLV---SGGTDNHLVLV---DLRPKGLDGARAERVLELVSITANKNTCPGD--RSAITP 421
Query: 362 SGLRIGVQEMTRVGMMEDEMKEIAHFM 388
GLR+G +T ED+ + + F+
Sbjct: 422 GGLRLGAPALTSRQFREDDFRRVVDFI 448
>gb|AAD33721.1| (AF136495) GlyA [Campylobacter lari]
Length = 213
Score = 164 bits (411), Expect = 2e-39
Identities = 81/218 (37%), Positives = 134/218 (61%), Gaps = 5/218 (2%)
Query: 48 HKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQP 107
+KYAEG+P +RYY GC++VDE+E I +E KLF ++A+++P SG+ ANQ V+ L P
Sbjct: 1 NKYAEGYPGKRYYGGCEFVDEIETIAIERCKKLFNCNFANVQPNSGSQANQGVYMALLNP 60
Query: 108 GDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVV 167
GD+++ + SHGGH++H ++ + E + + + I+ DK ++ +E++PK++V
Sbjct: 61 GDRILGMDLSHGGHLTHGSKVSSSGKVYESFFYGVELDG-RINYDKVREIAKEIKPKLIV 119
Query: 168 FGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKT 227
G S +P + +A EVGA++ D AH+ GL+ GE P A +++++THKT
Sbjct: 120 CGASAYPRVIDFAKFREIADEVGAYLFADIAHIAGLVVAGEHPSPF-PYAHVVSSTTHKT 178
Query: 228 FPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLH 265
GP+GG+I+ D+E K+ AIFPG+ +H
Sbjct: 179 LRGPRGGIIMCN---DEEIAKKINSAIFPGIQGGPLMH 213
>pir||H72067 glycine hydroxymethyltransferase (EC 2.1.2.1) - Chlamydophila
pneumoniae (strain CWL029) >gi|4376810|gb|AAD18661.1|
(AE001637) Serine Hydroxymethyltransferase
[Chlamydophila pneumoniae CWL029]
>gi|8978892|dbj|BAA98727.1| (AP002547) serine
hydroxymethyltransferase [Chlamydophila pneumoniae J138]
Length = 519
Score = 162 bits (406), Expect = 7e-39
Identities = 131/416 (31%), Positives = 205/416 (48%), Gaps = 50/416 (12%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
I+E + RSH + +IASEN +S SV A+ + KY EG P +R+Y C+ VD +E
Sbjct: 66 IDELKSQRSH-LKMIASENYSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWEC 124
Query: 74 VELFTKLFKSDYADLRPISGTNANQAVFFGL----------GQPGDKVIVLHTSH----- 118
VE +LF +D A ++P SG +AN + + G K + T
Sbjct: 125 VETAKELFAADCACVQPHSGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYTLL 184
Query: 119 ----------------GGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAE--KMIRE 160
GGH++H M L + +P+D D AE ++ +E
Sbjct: 185 KAEMSSCVCLGPSLNSGGHLTHGNVRLNVMSKL-MRCFPYDVNPDTECFDYAEISRLAKE 243
Query: 161 LEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQD---PLREGA 217
+PK+++ G S + L +A++ G+ + D AH GL+AGG F D P+ A
Sbjct: 244 YKPKVLIAGYSSYSRRLNFAVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPI-PYA 302
Query: 218 DIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEM 277
DI+T +THKT GP+GG++L + + T+ K + G L H +A K + E
Sbjct: 303 DIVTTTTHKTLRGPRGGLVLATR-EYESTLNKACPLMMGGPLP----HVIAAKTVALKEA 357
Query: 278 LEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAP 336
L + YA Q+V NA+ LAE G +++ G T +H +++D+ L G A
Sbjct: 358 LSVDFKKYAHQVVNNARRLAERFLSHGLRLL---TGGTDNHMMVIDLGSL-GISGKIAED 413
Query: 337 LLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
+L GI +N+N LP D + K + SG+R+G +T +GM DEM+E+A + +VL
Sbjct: 414 ILSSVGIAVNRNSLPSDAIGKW-DTSGIRLGTPALTTLGMGIDEMEEVADIIVKVL 468
>sp|Q9Z831|GLYA_CHLPN SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|11256994|pir||G81598 serine hydroxymethyltransferase
CP0232 [imported] - Chlamydophila pneumoniae (strain
AR39) >gi|7189160|gb|AAF38098.1| (AE002184) serine
hydroxymethyltransferase [Chlamydophila pneumoniae AR39]
Length = 497
Score = 162 bits (406), Expect = 7e-39
Identities = 131/416 (31%), Positives = 205/416 (48%), Gaps = 50/416 (12%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIG 73
I+E + RSH + +IASEN +S SV A+ + KY EG P +R+Y C+ VD +E
Sbjct: 44 IDELKSQRSH-LKMIASENYSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWEC 102
Query: 74 VELFTKLFKSDYADLRPISGTNANQAVFFGL----------GQPGDKVIVLHTSH----- 118
VE +LF +D A ++P SG +AN + + G K + T
Sbjct: 103 VETAKELFAADCACVQPHSGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYTLL 162
Query: 119 ----------------GGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAE--KMIRE 160
GGH++H M L + +P+D D AE ++ +E
Sbjct: 163 KAEMSSCVCLGPSLNSGGHLTHGNVRLNVMSKL-MRCFPYDVNPDTECFDYAEISRLAKE 221
Query: 161 LEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQD---PLREGA 217
+PK+++ G S + L +A++ G+ + D AH GL+AGG F D P+ A
Sbjct: 222 YKPKVLIAGYSSYSRRLNFAVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPI-PYA 280
Query: 218 DIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVITAAEM 277
DI+T +THKT GP+GG++L + + T+ K + G L H +A K + E
Sbjct: 281 DIVTTTTHKTLRGPRGGLVLATR-EYESTLNKACPLMMGGPLP----HVIAAKTVALKEA 335
Query: 278 LEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAP 336
L + YA Q+V NA+ LAE G +++ G T +H +++D+ L G A
Sbjct: 336 LSVDFKKYAHQVVNNARRLAERFLSHGLRLL---TGGTDNHMMVIDLGSL-GISGKIAED 391
Query: 337 LLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
+L GI +N+N LP D + K + SG+R+G +T +GM DEM+E+A + +VL
Sbjct: 392 ILSSVGIAVNRNSLPSDAIGKW-DTSGIRLGTPALTTLGMGIDEMEEVADIIVKVL 446
>pir||C81672 serine hydroxymethyltransferase TC0716 [imported] - Chlamydia
muridarum (strain Nigg) >gi|7190746|gb|AAF39528.1|
(AE002340) serine hydroxymethyltransferase [Chlamydia
muridarum]
Length = 497
Score = 159 bits (398), Expect = 6e-38
Identities = 134/439 (30%), Positives = 212/439 (47%), Gaps = 62/439 (14%)
Query: 1 MAYKEYRDKVLH--------FIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAE 52
+AY D +LH ++E + RS + +IASEN +S SV A+ + KY E
Sbjct: 23 VAYLAALDHLLHSFPSIGQSIVQELKSQRSR-LKMIASENFSSLSVQLAMGNLLTDKYCE 81
Query: 53 GWPRQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGL-------- 104
G P +R+Y C+ VD +E VE +LF ++ A ++P SG +AN +
Sbjct: 82 GSPFKRFYSCCENVDAIEWECVETAKELFGAESACVQPHSGADANLLAIMSIITQKIQSP 141
Query: 105 -----------GQPGDKVIVLHT------------SHGGHISHMPFGAAGMRGLEVHTWP 141
P + L + GGH++H M L +H P
Sbjct: 142 AVQRLGYKTINDLPEQEYEALKAEMSQYKCLGPSLNSGGHLTHGTVRINVMSKL-MHCLP 200
Query: 142 F----DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDA 197
+ D E F+ DV K+ +E P +++ G S + L +A++ GA + D
Sbjct: 201 YEVNLDTELFDYDV--IAKIAKEHRPTVLIAGYSSYSRRLNFATLKQIAEDCGAVLWVDM 258
Query: 198 AHVLGLIAGGEF---QDPLREGADIMTASTHKTFPGPQGGVILYKKFADDETIAKLQWAI 254
AH GL+AGG F ++P+ ADI+T +THKT GP+GG++L KK D T+ K +
Sbjct: 259 AHFAGLVAGGVFIGEENPI-PYADIVTTTTHKTLRGPRGGLVLAKKEYSD-TLNKACPLM 316
Query: 255 FPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQGY 313
G L H +A K + E + YA Q+V+NA+ LAE G +++ G
Sbjct: 317 MGGPLP----HVIAAKAVALKEAMTINFRKYAHQVVENARTLAEIFQRNGLRLL---TGG 369
Query: 314 TKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTR 373
T +H +I+D++ L G A +L GI +N+N +P D + + SG+R+G +T
Sbjct: 370 TDNHMLIIDLTSL-GVPGRIAEDMLTSVGIAVNRNSIPSDASGQW-KTSGIRLGTPALTT 427
Query: 374 VGMMEDEMKEIAHFMKRVL 392
+GM EM+E+A+ + +VL
Sbjct: 428 LGMGSAEMEEVANIIAKVL 446
>pir||T01759 glycine hydroxymethyltransferase (EC 2.1.2.1) A_IG002P16.3 -
Arabidopsis thaliana >gi|2191159|gb|AAB61045.1|
(AF007270) Similar to serine hydroxymethyltransferase;
coded for by A. thaliana cDNA T42313; coded for by A.
thaliana cDNA W43384 [Arabidopsis thaliana]
Length = 532
Score = 157 bits (392), Expect = 3e-37
Identities = 118/421 (28%), Positives = 199/421 (47%), Gaps = 58/421 (13%)
Query: 14 IEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQG---------CK 64
+E+ +W+ LI SEN TS SV +AV S +KY+EG+P RYY G +
Sbjct: 51 LEKARQWKG--FELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYVVCILLTR 108
Query: 65 YVDEVELIGVELFTKLFKSDYA----DLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGG 120
Y+D E + + + F+ D + +++ +SG+ AN V+ L +P ++++ L HGG
Sbjct: 109 YIDMAETLCQKRALEAFQLDPSKWGVNVQSLSGSPANFQVYTALLKPHERIMALDLPHGG 168
Query: 121 HISH------MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFP 174
H+SH A + E + D + ID D+ EK PK++V G S +
Sbjct: 169 HLSHGYQTDTKKISAVSI-FFETMPYRLDENTGYIDYDQLEKSAVLFRPKLIVAGASAYA 227
Query: 175 FPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGG 234
+ + V + A ++ D AH+ GL+A G P E AD++T +THK+ GP+G
Sbjct: 228 RLYDYARIRKVCNKQKAVMLADMAHISGLVAAGVIPSPF-EYADVVTTTTHKSLRGPRGA 286
Query: 235 VILYKKFADD----------ETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGE 282
+I ++K + + ++ A+FPG+ H H + G + A EY +
Sbjct: 287 MIFFRKGLKEINKQGKEVMYDYEDRINQAVFPGLQGGPHNHTITGLAVALKQARTPEY-K 345
Query: 283 AYAKQIVKNAKALAE----------------ALAEEGFKVIGEDQGYTKSHQVIVDVSDL 326
AY Q+++N AE L +G+ ++ G T +H V+V++ +
Sbjct: 346 AYQDQVLRNCSKFAELDIRPTVIISYGLSMQTLLAKGYDLV---SGGTDNHLVLVNLKN- 401
Query: 327 HPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAH 386
G +LE I NKN +P D V P G+R+G +T G +E++ ++A
Sbjct: 402 KGIDGSRVEKVLELVHIAANKNTVPGDVSAMV--PGGIRMGTPALTSRGFIEEDFAKVAE 459
Query: 387 F 387
+
Sbjct: 460 Y 460
>sp|O84439|GLYA_CHLTR SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|7433538|pir||H71516 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Chlamydia trachomatis (serotype D, strain
UW3/Cx) >gi|3328862|gb|AAC68029.1| (AE001316) Serine
Hydroxymethyltransferase [Chlamydia trachomatis]
Length = 497
Score = 155 bits (389), Expect = 7e-37
Identities = 132/440 (30%), Positives = 213/440 (48%), Gaps = 64/440 (14%)
Query: 1 MAYKEYRDKVLH--------FIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAE 52
+AY D +LH ++E + RS + +IASEN +S SV A+ + KY E
Sbjct: 23 VAYLASLDHLLHAFPSIGQSIVQELKSQRSR-LKMIASENFSSLSVQLAMGNLLTDKYCE 81
Query: 53 GWPRQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGL-------- 104
G P +R+Y C+ VD +E E +LF ++ A ++P SG +AN +
Sbjct: 82 GSPFKRFYSCCENVDAIEWECAETAKELFGAESAFVQPHSGADANLLAIMSIITQKIQSP 141
Query: 105 -----------------------GQPGDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWP 141
K + + GGH++H M L +H P
Sbjct: 142 AVQRLGYKTINDLPEQEYEALKAEMAQHKCLGPSLNSGGHLTHGTVRMNIMSKL-MHCLP 200
Query: 142 F----DNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDA 197
+ D E F D D+ K+ +E +P +++ G S + L +A++ GA + D
Sbjct: 201 YEVNLDTELF--DYDEIAKIAKEHKPTVLIAGYSSYSRRLNFATLKQIAEDCGAVLWVDM 258
Query: 198 AHVLGLIAGGEF---QDPLREGADIMTASTHKTFPGPQGGVILYKK-FADDETIAKLQWA 253
AH GL+AGG F ++P+ ADI+T +THKT GP+GG++L KK +A+ T+ K
Sbjct: 259 AHFAGLVAGGVFVGEENPM-PYADIVTTTTHKTLRGPRGGLVLAKKEYAN--TLNKACPL 315
Query: 254 IFPGVLSNHHLHHMAGKVITAAEMLEYG-EAYAKQIVKNAKALAEALAEEGFKVIGEDQG 312
+ G L H +A K I E + YA ++V+NA+ LAE G +++ G
Sbjct: 316 MMGGPLP----HVIAAKAIALKEAMTINFRKYAHKVVENARTLAEVFQRNGLRLL---TG 368
Query: 313 YTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMT 372
T +H +I+D++ L G A +L GI +N+N +P D + + SG+R+G +T
Sbjct: 369 GTDNHMLIIDLTSL-GVPGRIAEDMLTSVGIAVNRNTIPSDASGQW-KTSGIRLGTPALT 426
Query: 373 RVGMMEDEMKEIAHFMKRVL 392
+GM EM+E+A+ + +VL
Sbjct: 427 TLGMGSAEMEEVANIIVKVL 446
>sp|O62585|GLYC_ENCCU SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|3097067|emb|CAA06649.1| (AJ005644) serine
hydroxymethyltransferase [Encephalitozoon cuniculi]
Length = 460
Score = 155 bits (388), Expect = 9e-37
Identities = 122/408 (29%), Positives = 197/408 (47%), Gaps = 32/408 (7%)
Query: 5 EYRDKVLHFIEEHEKWRSH-TINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
E D LH + E R TINLIASEN S A S +KY+EG +RYY G
Sbjct: 15 EMADPELHALICGEVERQKKTINLIASENYAHQSAMEACGSVLTNKYSEGRVGERYYGGT 74
Query: 64 KYVDEVELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+VD +EL+ + +LF D ++P SG+ AN A++ + PG +++ L G
Sbjct: 75 HWVDRIELLCQKRALELFGLDPDAWGVYVQPYSGSPANFAIYTAVVPPGGRIMGLDLPSG 134
Query: 120 GHISHMPFGAAGMRGLEVHTWPFDNESFN------IDVDKAEKMIRELEPKIVVFGGSLF 173
GH++H R + + FD+ + ID + EK + P I++ G S +
Sbjct: 135 GHLTH--GYKTKTRKISASSVYFDSRPYTVGSNGLIDYEGLEKTFTDFLPHILICGYSAY 192
Query: 174 PFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQG 233
K L +A GAF+ D +H+ L+A G P E DI+ +T K GP+G
Sbjct: 193 SRDIDYKRLQSIAGRNGAFLFADISHISPLVASGLMNSPF-EHCDIVMTTTQKGLRGPRG 251
Query: 234 GVILYKKFA--DDETI---AKLQWAIFPGVLSNHHLHHMAG--KVITAAEMLEYGEAYAK 286
+I Y++ + ET+ A++ +A+FP + H H +AG + A E+ E Y +
Sbjct: 252 ALIFYRRAVTKNGETVDLDARINFAVFPMLQGGPHNHTIAGIASALLHAGTPEFAE-YTR 310
Query: 287 QIVKNAKALAEALAEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEAGIILN 346
++V+N++ L L G ++ G T +H ++VD+ G + + GI LN
Sbjct: 311 RVVENSRELCSRLQSLGLDIL---TGGTDNHMLLVDLRST-GVDGAAVEHMCDALGISLN 366
Query: 347 KNLLPWD--PLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVL 392
+N + + PL PSG+R+G +T G +EM+E+ + V+
Sbjct: 367 RNAIVGNSSPL----SPSGIRVGTYAVTARGFGPEEMREVGDIIGGVV 410
>gb|AAD33719.1| (AF136493) GlyA [Campylobacter jejuni]
Length = 213
Score = 155 bits (388), Expect = 9e-37
Identities = 77/218 (35%), Positives = 130/218 (59%), Gaps = 5/218 (2%)
Query: 48 HKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQP 107
+KYAEG+P +RYY GC++VDE+E + +E KLF +A+++P SG+ ANQ V+ L P
Sbjct: 1 NKYAEGYPGKRYYGGCEFVDEIETLAIERCKKLFNCKFANVQPNSGSQANQGVYAALINP 60
Query: 108 GDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVV 167
GDK++ + SHGGH++H ++ + E + + + ID +K ++ ++ +PK++V
Sbjct: 61 GDKILGMDLSHGGHLTHGAKVSSSGKMYESCFYGVELDG-RIDYEKVREIAKKEKPKLIV 119
Query: 168 FGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKT 227
G S + + +A E+GA++ D AH+ GL+ GE P +++++THKT
Sbjct: 120 CGASAYARVIDFAKFREIANEIGAYLFADIAHIAGLVVAGEHPSPFPH-THVVSSTTHKT 178
Query: 228 FPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLH 265
GP+GG+I+ D+E K+ AIFPG+ +H
Sbjct: 179 LRGPRGGIIMTN---DEELAKKINSAIFPGIQGGPLMH 213
>gb|AAD33720.1| (AF136494) GlyA [Campylobacter coli]
Length = 213
Score = 155 bits (388), Expect = 9e-37
Identities = 78/218 (35%), Positives = 130/218 (58%), Gaps = 5/218 (2%)
Query: 48 HKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQP 107
+KYAEG+P +RYY GC++VDE+E + +E KLF +A+++P SG+ ANQ V+ L P
Sbjct: 1 NKYAEGYPGKRYYGGCEFVDEIENLAIERCKKLFNCSFANVQPNSGSQANQGVYAALLNP 60
Query: 108 GDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVV 167
GDK++ + SHGGH++H ++ + E + + + I+ +K ++ ++PK++V
Sbjct: 61 GDKILGMDLSHGGHLTHGAKVSSSGKMYESFFYGVELDG-RINYEKVREIAHIVKPKLIV 119
Query: 168 FGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKT 227
G S + + +A EVGA++ D AH+ GL+ GE P A +++++THKT
Sbjct: 120 CGASAYARIIDFSKFREIADEVGAYLFADIAHIAGLVVAGEHPSPFPH-AHVVSSTTHKT 178
Query: 228 FPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLH 265
GP+GG+I+ D+E K+ AIFPG+ +H
Sbjct: 179 LRGPRGGIIMTN---DEELAKKINSAIFPGIQGGQLMH 213
>gb|AAD33722.1| (AF136496) GlyA [Campylobacter upsaliensis]
Length = 213
Score = 147 bits (368), Expect = 2e-34
Identities = 76/218 (34%), Positives = 128/218 (57%), Gaps = 5/218 (2%)
Query: 48 HKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSDYADLRPISGTNANQAVFFGLGQP 107
+KYAEG+P +RYY GC+ VDE+E + ++ KLF +A+++P SG+ ANQ V+ L
Sbjct: 1 NKYAEGYPGKRYYGGCEIVDEIETLAIQRCKKLFNCAFANVQPNSGSQANQGVYAALLNA 60
Query: 108 GDKVIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVV 167
GD+++ + SHGGH++H ++ + E + + + I+ +K ++ ++PK++V
Sbjct: 61 GDRILGMDLSHGGHLTHGAKVSSSGKMYESFFYGVELDG-RINYEKVREIAHIVKPKLIV 119
Query: 168 FGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKT 227
G S + + +A EVGA++ D AH+ GL+ GE P A I++++THKT
Sbjct: 120 CGASAYARIIDFAKFREIADEVGAYLFADIAHIAGLVVAGEHPSPFPH-AHIVSSTTHKT 178
Query: 228 FPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLH 265
GP+GG+I+ D+E K+ AIFPG+ +H
Sbjct: 179 LRGPRGGIIMCN---DEEIAKKINSAIFPGIQGGPLMH 213
>emb|CAB54840.1| (Y14487) cytosolic serine hydroxymethyltransferase [Homo sapiens]
Length = 347
Score = 146 bits (365), Expect = 4e-34
Identities = 99/318 (31%), Positives = 167/318 (52%), Gaps = 24/318 (7%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 32 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 91
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E + + + +K D +++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 92 LETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 151
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R PK+++ G S +
Sbjct: 152 GFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEY 211
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A E GA+++ D AH+ GL+A G P E ++T +THKT G + G+I Y+
Sbjct: 212 ARLRKIADENGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGCRAGMIFYR 270
Query: 240 ---KFADDETIAKLQW--------AIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEAYAK 286
K D +T ++ + A+FPG+ H H +AG + A LE+ + Y
Sbjct: 271 KGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEF-KVYQH 329
Query: 287 QIVKNAKALAEALAEEGF 304
Q+V N +AL+EAL E G+
Sbjct: 330 QVVANCRALSEALTELGY 347
>emb|CAB54839.1| (Y14486) cytosolic serine hydroxymethyltransferase [Homo sapiens]
Length = 310
Score = 132 bits (329), Expect = 7e-30
Identities = 85/255 (33%), Positives = 135/255 (52%), Gaps = 21/255 (8%)
Query: 149 IDVDKAEKMIRELEPKIVVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGE 208
I+ D+ E+ R PK+++ G S + L +A E GA+++ D AH+ GL+A G
Sbjct: 8 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 67
Query: 209 FQDPLREGADIMTASTHKTFPGPQGGVILYK---KFADDETIAKLQW--------AIFPG 257
P E ++T +THKT G + G+I Y+ K D +T ++ + A+FPG
Sbjct: 68 VPSPF-EHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPG 126
Query: 258 VLSNHHLHHMAGKVIT--AAEMLEYGEAYAKQIVKNAKALAEALAEEGFKVIGEDQGYTK 315
+ H H +AG + A LE+ + Y Q+V N +AL+EAL E G+K++ G +
Sbjct: 127 LQGGPHNHAIAGVAVALKQAMTLEF-KVYQHQVVANCRALSEALTELGYKIV---TGGSD 182
Query: 316 SHQVIVDVSDLHPAGGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVG 375
+H ++VD+ GG A +LE I NKN P D PSGLR+G +T G
Sbjct: 183 NHLILVDLRS-KGTDGGRAEKVLEACSIACNKNTCPGD--RSALRPSGLRLGTPALTSRG 239
Query: 376 MMEDEMKEIAHFMKR 390
++E + +++AHF+ R
Sbjct: 240 LLEKDFQKVAHFIHR 254
>sp|P50431|GLYC_MOUSE SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT)
>gi|2137764|pir||JC4959 serine hydroxymethyltransferase
(EC 2.1.2.-) 2 - mouse >gi|1139581|emb|CAA64226.1|
(X94479) hydroxymethyltransferase [Mus musculus]
Length = 316
Score = 123 bits (306), Expect = 4e-27
Identities = 83/298 (27%), Positives = 147/298 (48%), Gaps = 27/298 (9%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
K+ +V I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G
Sbjct: 21 KDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSSLNNKYSEGYPGQRYYGGT 80
Query: 64 KYVDEVELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+++DE+E++ + + + D +++P SG+ AN AV+ L +P +++ L G
Sbjct: 81 EFIDELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDG 140
Query: 120 GHISH--------MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGS 171
GH++H + + + +P E+ I+ D+ E+ PK+++ G S
Sbjct: 141 GHLTHGFMTDKKKISATSIFFESMPYKVYP---ETGYINYDQLEENASLFHPKLIIAGTS 197
Query: 172 LFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGP 231
+ L +A + GA+++ D AH+ GL+A G P E ++T +THKT G
Sbjct: 198 CYSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGC 256
Query: 232 QGGVILYKK-------FADDETIAKLQ----WAIFPGVLSNHHLHHMAGKVITAAEML 278
+ G+I Y+K ET +L+ A+FPG+ H H + G + + +
Sbjct: 257 RAGMIFYRKGVRSVDPKTGKETYYELESLINSAVFPGLQGGPHNHAIRGVAVALKQAM 314
>gb|AAA36019.1| (L23928) serine hydroxymethyltransferase [Homo sapiens]
Length = 403
Score = 122 bits (303), Expect = 8e-27
Identities = 76/245 (31%), Positives = 130/245 (53%), Gaps = 10/245 (4%)
Query: 9 KVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDE 68
+V + I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G +++DE
Sbjct: 32 EVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDE 91
Query: 69 VELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+E + + + +K D +++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 92 LETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 151
Query: 125 -----MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGSLFPFPHPV 179
+A E + + ++ I+ D+ E+ R PK+++ G S +
Sbjct: 152 GFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEY 211
Query: 180 KELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGPQGGVILYK 239
L +A E GA+++ D AH+ GL+A G P E ++T +THKT G + G+I Y+
Sbjct: 212 ARLRKIADENGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGCRAGMIFYR 270
Query: 240 KFADD 244
K D
Sbjct: 271 KGGSD 275
>gi|6677943 serine hydroxymethyl transferase 1 (soluble) [Mus musculus]
>gi|2137763|pir||JC4958 serine hydroxymethyltransferase
(EC 2.1.2.-) 1 - mouse >gi|1139579|emb|CAA64225.1|
(X94478) hydroxymethyltransferase [Mus musculus]
Length = 309
Score = 117 bits (291), Expect = 2e-25
Identities = 73/249 (29%), Positives = 129/249 (51%), Gaps = 16/249 (6%)
Query: 4 KEYRDKVLHFIEEHEKWRSHTINLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGC 63
K+ +V I++ + + LIASEN S +V A+ S +KY+EG+P QRYY G
Sbjct: 21 KDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSSLNNKYSEGYPGQRYYGGT 80
Query: 64 KYVDEVELIGVELFTKLFKSD----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHG 119
+++DE+E++ + + + D +++P SG+ AN AV+ L +P +++ L G
Sbjct: 81 EFIDELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDG 140
Query: 120 GHISH--------MPFGAAGMRGLEVHTWPFDNESFNIDVDKAEKMIRELEPKIVVFGGS 171
GH++H + + + +P E+ I+ D+ E+ PK+++ G S
Sbjct: 141 GHLTHGFMTDKKKISATSIFFESMPYKVYP---ETGYINYDQLEENASLFHPKLIIAGTS 197
Query: 172 LFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTHKTFPGP 231
+ L +A + GA+++ D AH+ GL+A G P E ++T +THKT G
Sbjct: 198 CYSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPF-EHCHVVTTTTHKTLRGC 256
Query: 232 QGGVILYKK 240
+ G+I Y+K
Sbjct: 257 RAGMIFYRK 265
>sp|P50434|GLYA_CORS1 SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT)
>gi|2117694|pir||I40886 glycine hydroxymethyltransferase
(EC 2.1.2.1) - Corynebacterium sp. (fragment)
>gi|927588|gb|AAC43458.1| (U23955) serine
hydroxymethyltransferase [Corynebacterium sp.]
Length = 260
Score = 101 bits (249), Expect = 2e-20
Identities = 76/232 (32%), Positives = 114/232 (48%), Gaps = 11/232 (4%)
Query: 166 VVFGGSLFPFPHPVKELAPVAKEVGAFVVYDAAHVLGLIAGGEFQDPLREGADIMTASTH 225
+V G S +P +A +VGA++ D AH GL+A G P+ A ++T++TH
Sbjct: 1 IVAGWSAYPRQLDFVRFREIADKVGAYLFVDMAHFAGLVATGLHPSPVPH-AHVVTSTTH 59
Query: 226 KTFPGPQGGVILYKKFADDETIAKLQWAIFPGVLSNHHLHHMAGKVIT--AAEMLEYGEA 283
KT GP+GG+IL D E KL A+FPG H +AGK + A E+ E
Sbjct: 60 KTLAGPRGGIILSN---DAEIAKKLNSAVFPGQQGGPLEHVIAGKAVAFKIAASAEFKER 116
Query: 284 YAKQIVKNAKALAEAL--AEEGFKVIGEDQGYTKSHQVIVDVSDLHPAGGGWAAPLLEEA 341
+ + ++ LA+ L A+ K I G T H V+VD+ G A LL +
Sbjct: 117 QQRTLA-GSRILAQRLTQADVAAKGISVLTGGTDVHLVLVDLRH-SELDGQQAEDLLAKV 174
Query: 342 GIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIAHFMKRVLL 393
I +N+N +P+DP + SGLRIG + G E+ E+A + + L+
Sbjct: 175 EITVNRNSVPFDPRPPMT-TSGLRIGTPALATRGFSEEAFAEVAEIIAQTLI 225
>gb|AAF68430.1|AF239165_1 (AF239165) serine hydroxymethyltransferase [Sus scrofa]
Length = 158
Score = 74.5 bits (180), Expect = 2e-12
Identities = 39/104 (37%), Positives = 64/104 (61%), Gaps = 4/104 (3%)
Query: 25 INLIASENITSPSVNRAVASGFMHKYAEGWPRQRYYQGCKYVDEVELIGVELFTKLFKSD 84
+ LIASEN S +V A+ S +KY+EG+P QRYY G +++DE+EL+ +++ D
Sbjct: 12 LELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELELLCQRRALQVYGLD 71
Query: 85 ----YADLRPISGTNANQAVFFGLGQPGDKVIVLHTSHGGHISH 124
+++P SG+ AN AV+ L +P +++ L GGH++H
Sbjct: 72 PQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTH 115
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.138 0.415
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 172010631
Number of Sequences: 2977
Number of extensions: 7774427
Number of successful extensions: 19864
Number of sequences better than 1.0e-10: 116
Number of HSP's better than 0.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 19265
Number of HSP's gapped (non-prelim): 124
length of query: 427
length of database: 189,106,746
effective HSP length: 54
effective length of query: 373
effective length of database: 156,788,448
effective search space: 58482091104
effective search space used: 58482091104
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 166 (69.1 bits)