BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2106 (mvaA) DE:3-hydroxy-3-methylglutaryl-coenzyme A
reductase (mvaA)
(411 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9V1R3|HMDH_PYRAB 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 812 0.0
sp|O59469|HMDH_PYRHO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 771 0.0
pir||E71191 probable 3-hydroxy-3-methylglutaryl coenzyme A reduc... 653 0.0
sp|Q9YAS4|HMDH_AERPE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 466 e-130
sp|Q58116|HMDH_METJA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 457 e-127
gb|AAK40851.1| 3 hydroxy 3 methylglutaryl coenzyme a reductase [... 440 e-122
emb|CAB57768.1| (Y18930) 3-hydroxy-3-methylglutaryl-coenzyme A r... 440 e-122
sp|O08424|HMDH_SULSO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 439 e-122
sp|O26662|HMDH_METTH 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 437 e-122
sp|Q59468|HMDH_HALVO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 420 e-116
gb|AAG20075.1| (AE005087) 3-hydroxy-3-methylglutaryl-coenzyme A ... 404 e-111
gb|AAG35211.1|AF123438_1 (AF123438) 3-hydroxy-3-methylglutaryl c... 377 e-103
gb|AAA68966.1| (U14625) 3-hydroxy-3-methylglutaryl coenzyme A re... 362 3e-99
gb|AAA68965.1| (U14624) 3-hydroxy-3-methylglutaryl coenzyme A re... 362 3e-99
sp|Q9XHL5|HMD3_ORYSA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 359 4e-98
pir||T03382 probable hydroxymethylglutaryl-CoA reductase (NADPH)... 358 5e-98
sp|Q41438|HMD3_SOLTU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 357 1e-97
pir||T04302 probable hydroxymethylglutaryl-CoA reductase (NADPH)... 357 1e-97
sp|P14891|HMD1_ARATH 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 356 2e-97
sp|O64967|HMD2_GOSHI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 356 3e-97
sp|P48021|HMDH_CAMAC 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 356 3e-97
pir||T04120 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 356 3e-97
sp|Q03163|HMDH_CATRO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 355 4e-97
sp|O24594|HMDH_MAIZE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 355 4e-97
sp|P29057|HMD1_HEVBR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 354 1e-96
sp|P48020|HMD1_SOLTU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 354 1e-96
pir||S59946 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 354 1e-96
dbj|BAA36291.1| (AB021862) HMG-CoA reductase [Cucumis melo] 353 2e-96
gb|AAC15475.1| (AF034760) 3-hydroxy-3-methylglutaryl coenzyme A ... 353 2e-96
sp|P34135|HMD1_DICDI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 353 3e-96
sp|Q00583|HMD3_HEVBR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 352 4e-96
sp|Q01559|HMDH_NICSY 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 352 5e-96
pir||S29623 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 351 6e-96
gb|AAB62581.1| (U68072) 3-hydroxy-3-methylglutaryl CoA reductase... 349 2e-95
pir||S29622 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 349 4e-95
sp|P43256|HMD2_ARATH 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 349 4e-95
sp|P48022|HMD2_LYCES 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 347 2e-94
gb|AAB69726.1| (U72145) 3-hydroxy-3-methylglutaryl coenzyme a re... 347 2e-94
gb|AAD03789.1| (U43711) 3-hydroxy-3-methylglutaryl-coenzyme A re... 346 2e-94
sp|Q41437|HMD2_SOLTU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 346 3e-94
sp|O64966|HMD1_GOSHI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 344 1e-93
sp|Q9XEL8|HMD2_CAPAN 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 344 1e-93
sp|P48019|HMD1_ORYSA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 342 4e-93
emb|CAB97179.1| (X58371) 3-hydroxy-3-methylglutaryl coenzyme A r... 341 7e-93
sp|P34136|HMD2_DICDI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 341 9e-93
sp|Q29512|HMDH_RABIT 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 339 5e-92
pdb|1DQ8|A Chain A, Complex Of The Catalytic Portion Of Human Hm... 337 1e-91
gb|AAD20975.2| (AF071750) 3-hydroxy-3-methylglutaryl coenzyme A ... 337 1e-91
sp|P00347|HMDH_CRIGR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 336 2e-91
gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Homo... 336 2e-91
pir||A23586 hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) - ... 336 2e-91
sp|P09610|HMDH_MESAU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 336 2e-91
gi|6981028 3 [Rattus norvegicus] >gi|1708252|sp|P51639|HMDH_RAT ... 332 5e-90
gb|AAB62280.1| (L78791) hydroxymethylglutaryl CoA reductase [Try... 332 5e-90
gb|AAD38406.1|AF155593_1 (AF155593) 3-hydroxy-3-methylglutaryl c... 332 6e-90
gb|AAA33358.1| (M74798) 3-hydroxy-3-methylglutaryl-coenzyme A re... 330 1e-89
sp|P20715|HMDH_XENLA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 328 5e-89
gb|AAB69727.1| (U72146) 3-hydroxy-3-methylglutaryl coenzyme A re... 328 7e-89
pir||S30338 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 326 3e-88
sp|P54960|HMDH_BLAGE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 326 3e-88
gb|AAF80373.1| (AF159138) HMG-CoA reductase [Dendroctonus jeffre... 324 8e-88
sp|P16393|HMDH_STRPU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 324 1e-87
sp|O74164|HMDH_PICJA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 323 2e-87
pir||T15979 hypothetical protein F08F8.2 - Caenorhabditis elegan... 318 6e-86
sp|Q12577|HMDH_GIBFU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 316 2e-85
pir||T41022 3-hydroxy-3-methylglutaryl-coenzyme a reductase - fi... 316 3e-85
gi|6323565 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduc... 315 5e-85
sp|Q10283|HMDH_SCHPO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 314 1e-84
gi|6323483 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduc... 311 8e-84
gb|AAD47596.1| (AF142473) HMG-CoA reductase [Artemisia annua] 305 6e-82
sp|Q9Y7D2|HMDH_ASPTE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 305 8e-82
gb|AAF56175.1| (AE003744) Hmgcr gene product [Drosophila melanog... 303 3e-81
sp|O76819|HMDH_AGRIP 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 300 1e-80
sp|P14773|HMDH_DROME 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 293 3e-78
pir||G82425 3-hydroxy-3-methylglutaryl CoA reductase VCA0723 [im... 285 6e-76
gb|AAC15476.1| (AF034761) 3-hydroxy-3-methylglutaryl coenzyme A ... 273 3e-72
sp|P16237|HMDH_SCHMA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 268 1e-70
dbj|BAA70975.1| (AB013457) 3-hydroxy-3-methylglutaryl coenzyme A... 251 1e-65
gb|AAB23278.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase, ... 250 3e-65
dbj|BAA74565.1| (AB015626) 3-hydroxy-3-methylglutaryl coenzyme A... 249 3e-65
pir||PQ0187 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 248 8e-65
pir||S59945 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 241 1e-62
gb|AAC72378.1| (AF096838) 3-hydroxy-3-methylglutaryl coenzyme A ... 241 1e-62
dbj|BAA74566.1| (AB015627) 3-hydroxy-3-methylglutaryl coenzyme A... 238 1e-61
gb|AAF80475.1|AF162705_1 (AF162705) 3-hydroxy-3-methylglutaryl c... 213 4e-54
pir||S33175 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 211 1e-53
sp|Q01237|HMDH_MOUSE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 210 2e-53
pir||A43533 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 210 2e-53
sp|P29058|HMD2_HEVBR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 206 4e-52
emb|CAA63971.1| (X94308) HMG-CoA-reductase [Sphaceloma manihotic... 188 1e-46
pir||PQ0762 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 156 4e-37
gb|AAB29931.1| 3-hydroxy-3-methylglutaryl coenzyme A reductase, ... 156 5e-37
pir||PQ0763 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 155 8e-37
pir||PQ0761 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 148 8e-35
gb|AAB29929.1| 3-hydroxy-3-methylglutaryl coenzyme A reductase, ... 148 8e-35
emb|CAA52787.1| (X74783) 3-hydroxy-3-methyl glutaryl coenzyme A ... 141 1e-32
gb|AAD09278.1| (U97683) 3-hydroxy-3-methylglutaryl-coenzyme A re... 132 9e-30
gb|AAB04043.1| (L40938) HMGR CoA reductase [Lycopersicon esculen... 117 2e-25
pir||T10099 probable hydroxymethylglutaryl-CoA reductase (NADPH)... 100 5e-20
pir||S42214 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 94 2e-18
pir||S42215 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 94 3e-18
pir||S42212 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 93 5e-18
gi|11499325 3-hydroxy-3-methylglutaryl-coenzyme A reductase (mva... 93 5e-18
pir||S42213 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 92 1e-17
pir||S17343 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 90 4e-17
sp|Q12649|HMDH_PHYBL 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUC... 90 5e-17
gb|AAG02444.1|AF290094_2 (AF290094) acetyl-CoA acetyltransferase... 81 2e-14
pir||T10269 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.... 81 3e-14
emb|CAB53533.1| (AJ237676) 3-hydroxy-3-methylglutaryl CoA reduct... 80 6e-14
gb|AAD14314.1|S79678_1 (S79678) 3-hydroxy-3-methylglutaryl coenz... 72 1e-11
>sp|Q9V1R3|HMDH_PYRAB 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|7447707|pir||G75150
3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaa)
PAB2106 - Pyrococcus abyssi (strain Orsay)
>gi|5457796|emb|CAB49286.1| (AJ248284)
3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA)
[Pyrococcus abyssi]
Length = 411
Score = 812 bits (2075), Expect = 0.0
Identities = 411/411 (100%), Positives = 411/411 (100%)
Query: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDP 60
MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDP
Sbjct: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDP 60
Query: 61 NELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTE 120
NELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTE
Sbjct: 61 NELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTE 120
Query: 121 AGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKP 180
AGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKP
Sbjct: 121 AGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKP 180
Query: 181 FIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAV 240
FIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAV
Sbjct: 181 FIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAV 240
Query: 241 NFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIV 300
NFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIV
Sbjct: 241 NFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIV 300
Query: 301 GAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALS 360
GAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALS
Sbjct: 301 GAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALS 360
Query: 361 IMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
IMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR
Sbjct: 361 IMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
>sp|O59469|HMDH_PYRHO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
Length = 413
Score = 771 bits (1969), Expect = 0.0
Identities = 383/408 (93%), Positives = 402/408 (97%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNEL 63
LN+E+IIEKVANGEIK +QVEKYVNGDKRLATEIRRKALE++LGI L HIG+YSIDPNEL
Sbjct: 6 LNIEEIIEKVANGEIKFYQVEKYVNGDKRLATEIRRKALEKRLGIKLHHIGYYSIDPNEL 65
Query: 64 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 123
IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG
Sbjct: 66 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 125
Query: 124 VVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIV 183
VVTT++DDKMTRAPLIRCPNARRAREVA+WV+ENL+YLQEKAV+KVTRHGKLR VKPFIV
Sbjct: 126 VVTTLIDDKMTRAPLIRCPNARRAREVAKWVEENLDYLQEKAVSKVTRHGKLRGVKPFIV 185
Query: 184 GNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFI 243
GNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFI
Sbjct: 186 GNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFI 245
Query: 244 LGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAI 303
LGRGKTV+AEA+VPR+IVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHF NIVGAI
Sbjct: 246 LGRGKTVIAEAVVPRKIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFANIVGAI 305
Query: 304 FLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
FLATGQDEAQITEG+HGITIAEVTP+GDLYISITMPSLEIGTVGGGTRVP+QREAL IMG
Sbjct: 306 FLATGQDEAQITEGAHGITIAEVTPDGDLYISITMPSLEIGTVGGGTRVPSQREALEIMG 365
Query: 364 VAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
VAGGGDPPG+NAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR
Sbjct: 366 VAGGGDPPGINAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 413
>pir||E71191 probable 3-hydroxy-3-methylglutaryl coenzyme A reductase -
Pyrococcus horikoshii >gi|3258241|dbj|BAA30924.1|
(AP000007) 341aa long hypothetical
3-hydroxy-3-methylglutaryl coenzyme A reductase
[Pyrococcus horikoshii]
Length = 341
Score = 653 bits (1667), Expect = 0.0
Identities = 325/341 (95%), Positives = 338/341 (98%)
Query: 71 MIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILD 130
MIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTT++D
Sbjct: 1 MIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTLID 60
Query: 131 DKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLR 190
DKMTRAPLIRCPNARRAREVA+WV+ENL+YLQEKAV+KVTRHGKLR VKPFIVGNNLYLR
Sbjct: 61 DKMTRAPLIRCPNARRAREVAKWVEENLDYLQEKAVSKVTRHGKLRGVKPFIVGNNLYLR 120
Query: 191 FEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTV 250
FEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTV
Sbjct: 121 FEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTV 180
Query: 251 VAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIFLATGQD 310
+AEA+VPR+IVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHF NIVGAIFLATGQD
Sbjct: 181 IAEAVVPRKIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFANIVGAIFLATGQD 240
Query: 311 EAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGGDP 370
EAQITEG+HGITIAEVTP+GDLYISITMPSLEIGTVGGGTRVP+QREAL IMGVAGGGDP
Sbjct: 241 EAQITEGAHGITIAEVTPDGDLYISITMPSLEIGTVGGGTRVPSQREALEIMGVAGGGDP 300
Query: 371 PGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
PG+NAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR
Sbjct: 301 PGINAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 341
>sp|Q9YAS4|HMDH_AERPE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|7447708|pir||E72573 probable
3-hydroxy-3-methylglutaryl-coenzyme A reductase APE1869
- Aeropyrum pernix (strain K1)
>gi|5105561|dbj|BAA80874.1| (AP000062) 421aa long
hypothetical 3-hydroxy-3-methylglutaryl-coenzyme A
reductase [Aeropyrum pernix]
Length = 421
Score = 466 bits (1185), Expect = e-130
Identities = 240/411 (58%), Positives = 309/411 (74%), Gaps = 4/411 (0%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPN 61
K +ED+++K+A+G + ++EK + G+ A +RR LER G SL + +D
Sbjct: 8 KPRRLEDLVDKLASGSLSHSRLEKEL-GNANEAALVRRLYLERLTGASLSSVASTILDFQ 66
Query: 62 ELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEA 121
EL GRNIEN IG VQ+P+GVAGPL+ING+YA+G+FYIPLATTEGALVASVNRG A+T +
Sbjct: 67 ELYGRNIENPIGAVQVPVGVAGPLRINGDYARGDFYIPLATTEGALVASVNRGAKAITLS 126
Query: 122 GGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPF 181
GG ++ D MTRAPL+ P+ A +A WV++ + L+ VA VTRHG+L+ + P+
Sbjct: 127 GGARAKVIKDGMTRAPLLWTPSVYEAHRLAMWVEDRIEDLR-SVVAGVTRHGRLQHIYPY 185
Query: 182 IVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFP-DVRYLALSGNLCVDKKPNAV 240
I+GN ++LR F TGDAMGMNMVTI+S+ I + IEE + D + +ALSGN+C DKKP A+
Sbjct: 186 IIGNLVWLRLSFSTGDAMGMNMVTISSDRICRYIEENYDGDAKCIALSGNMCTDKKPAAI 245
Query: 241 NFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIV 300
N ILGRGK VVAEA++ E+V+ LKTTP+ I VN KNL+GSA AGS+ FNAHF NI+
Sbjct: 246 NKILGRGKYVVAEAVIKGEVVKNVLKTTPQNINLVNVTKNLLGSAAAGSHSFNAHFANII 305
Query: 301 GAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALS 360
AIF+ATGQD AQ+ E S G T EV E DLYIS+T+PSLE+GTVGGGTR+PTQRE L+
Sbjct: 306 AAIFIATGQDAAQVVESSMGYTWTEVRGE-DLYISVTLPSLEVGTVGGGTRLPTQRELLA 364
Query: 361 IMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GVAGGG+PPG NA K AEI+A AVLAGEL+LL+AIAA LARAH++LGR
Sbjct: 365 LLGVAGGGNPPGSNALKLAEIIASAVLAGELNLLSAIAAGQLARAHELLGR 415
>sp|Q58116|HMDH_METJA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|2127720|pir||A64388 3-hydroxy-3-methylglutaryl
coenzyme A reductase (EC 1.1.1.-) - Methanococcus
jannaschii >gi|1591421|gb|AAB98699.1| (U67517)
3-hydroxy-3-methylglutaryl coenzyme A reductase
[Methanococcus jannaschii]
Length = 405
Score = 457 bits (1163), Expect = e-127
Identities = 242/412 (58%), Positives = 300/412 (72%), Gaps = 14/412 (3%)
Query: 5 NVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELI 64
N DI+EK+ NGEIK +Q++K ++ATEIRRK +E+K+GI KHI +YSID +
Sbjct: 3 NYNDILEKMLNGEIKPYQLDKMFGS--KIATEIRRKFIEKKVGIEFKHICNYSIDEEMAM 60
Query: 65 GRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGV 124
+NIENMIG +QIP+G AGPLKINGEYAKGEFYIPLATTEGALVASVNRGCS +T+ GG
Sbjct: 61 KKNIENMIGAIQIPLGFAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSIITKCGGA 120
Query: 125 VTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKP-FIV 183
++DDKMTRAP ++ + A +V +W++EN ++E A TRHGKL ++P IV
Sbjct: 121 TVRVIDDKMTRAPCLKTKSVVDAIKVRDWIRENFERIKEVA-ESTTRHGKLIKIEPILIV 179
Query: 184 GNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPD----VRYLALSGNLCVDKKPNA 239
G NLY RF F+TGDAMGMNMVTIA+E+ IE E V+ +A+SGN CVDKKP+
Sbjct: 180 GRNLYPRFVFKTGDAMGMNMVTIATEKACNFIEGELKKEGIFVKTVAVSGNACVDKKPSG 239
Query: 240 VNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNI 299
+N I GRGK++VAE + + V K LKTT + IAEVN KN +GSA + S GFNAH+ NI
Sbjct: 240 MNLINGRGKSIVAEVFLTEKEVNKYLKTTSQAIAEVNRLKNYIGSAISNSMGFNAHYANI 299
Query: 300 VGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREAL 359
+GAIFLATGQDEA I EGS GIT+AEV +G LY S+T+P + IGTVGGGTRV TQ+E L
Sbjct: 300 IGAIFLATGQDEAHIVEGSLGITMAEVEDDG-LYFSVTLPDVPIGTVGGGTRVETQKECL 358
Query: 360 SIMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++G G A KFAEIV AVLAGELSLL A+AA HL +AH+ LGR
Sbjct: 359 EMLGCYGDN-----KALKFAEIVGAAVLAGELSLLGALAAGHLGKAHQELGR 405
>gb|AAK40851.1| 3 hydroxy 3 methylglutaryl coenzyme a reductase [Sulfolobus
solfataricus]
Length = 409
Score = 440 bits (1120), Expect = e-122
Identities = 217/409 (53%), Positives = 301/409 (73%), Gaps = 5/409 (1%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNEL 63
+ +++++EK+ GEI H+V+ + + + RR ALE+ +G+ L IG ID +E+
Sbjct: 1 MKIDEVVEKLVKGEISFHEVDNLLEANAAMVA--RRLALEKIVGVGLPSIGSTVIDYSEI 58
Query: 64 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 123
+N EN+IG +QIP+G+ GP+++NG+YAKG+FY+P+ATTEGAL+ASVNRG A+T +GG
Sbjct: 59 KNKNAENVIGAIQIPLGIVGPIRVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGG 118
Query: 124 VVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIV 183
V +L D+MTRAP+ + + + ++++ENL ++ A + + HGKL+ + PF++
Sbjct: 119 VRAKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIANS-TSHHGKLKSITPFVL 177
Query: 184 GNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFI 243
GNN++LRF FETGDAMGMNMVTIA E++ + IEE FP LA+SGN+C DKK VN +
Sbjct: 178 GNNVWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSL 237
Query: 244 LGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYG-FNAHFGNIVGA 302
GRGKTVVAEA++ ++++ L + +LI ++N KN +G+A+AGS FNAHF NIV A
Sbjct: 238 FGRGKTVVAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTA 297
Query: 303 IFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIM 362
IF+ATGQD AQI E S G T EV E DLYIS+T+PSLE+GTVGGGTR+PTQ+EALSIM
Sbjct: 298 IFIATGQDVAQIVESSSGYTWTEVRGE-DLYISVTLPSLEVGTVGGGTRLPTQKEALSIM 356
Query: 363 GVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
GV G G+PPG NAKK AEI+A VL+GEL+LLAA++ K L +AH LGR
Sbjct: 357 GVYGSGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAHAKLGR 405
>emb|CAB57768.1| (Y18930) 3-hydroxy-3-methylglutaryl-coenzyme A reductase
[Sulfolobus solfataricus]
Length = 409
Score = 440 bits (1120), Expect = e-122
Identities = 217/409 (53%), Positives = 301/409 (73%), Gaps = 5/409 (1%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNEL 63
+ +++++EK+ GEI H+V+ + + + RR ALE+ +G+ L IG ID +E+
Sbjct: 1 MKIDEVVEKLVKGEISFHEVDNLLEANAAMVA--RRLALEKIVGVGLPSIGSTVIDYSEI 58
Query: 64 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 123
+N EN+IG +QIP+G+ GP+++NG+YAKG+FY+P+ATTEGAL+ASVNRG A+T +GG
Sbjct: 59 KNKNAENVIGAIQIPLGIVGPIRVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGG 118
Query: 124 VVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIV 183
V +L D+MTRAP+ + + + ++++ENL ++ A + + HGKL+ + PF++
Sbjct: 119 VRAKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIANS-TSHHGKLKSITPFVL 177
Query: 184 GNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFI 243
GNN++LRF FETGDAMGMNMVTIA E++ + IEE FP LA+SGN+C DKK VN +
Sbjct: 178 GNNVWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSL 237
Query: 244 LGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYG-FNAHFGNIVGA 302
GRGKTVVAEA++ ++++ L + +LI ++N KN +G+A+AGS FNAHF NIV A
Sbjct: 238 FGRGKTVVAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTA 297
Query: 303 IFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIM 362
IF+ATGQD AQI E S G T EV E DLYIS+T+PSLE+GTVGGGTR+PTQ+EALSIM
Sbjct: 298 IFIATGQDVAQIVESSSGYTWTEVRGE-DLYISVTLPSLEVGTVGGGTRLPTQKEALSIM 356
Query: 363 GVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
GV G G+PPG NAKK AEI+A VL+GEL+LLAA++ K L +AH LGR
Sbjct: 357 GVYGSGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAHAKLGR 405
>sp|O08424|HMDH_SULSO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|11279275|pir||T51306 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) [validated] - Sulfolobus
solfataricus >gi|2130564|gb|AAC45370.1| (U95360)
3-hydroxy-3-methylglutaryl coenzyme A reductase
[Sulfolobus solfataricus]
Length = 409
Score = 439 bits (1117), Expect = e-122
Identities = 216/409 (52%), Positives = 301/409 (72%), Gaps = 5/409 (1%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNEL 63
+ +++++EK+ GEI H+V+ + + + RR ALE+ +G+ L IG ID +E+
Sbjct: 1 MKIDEVVEKLVKGEISFHEVDNLLEANAAMVA--RRLALEKIVGVGLPSIGSTVIDYSEI 58
Query: 64 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 123
+N EN+IG +QIP+G+ GP+++NG+YAKG+FY+P+ATTEGAL+ASVNRG A+T +GG
Sbjct: 59 KNKNAENVIGAIQIPLGIVGPIRVNGDYAKGDFYVPMATTEGALIASVNRGIKAVTLSGG 118
Query: 124 VVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIV 183
V +L D+MTRAP+ + + + ++++ENL ++ A + + HGKL+ + PF++
Sbjct: 119 VRAKVLKDEMTRAPVFKFDSIEQIPNFLKFIEENLEKIRNIANS-TSHHGKLKSITPFVL 177
Query: 184 GNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFI 243
GNN++LRF FETGDAMGMNMVTIA E++ + IEE FP LA+SGN+C DKK VN +
Sbjct: 178 GNNVWLRFSFETGDAMGMNMVTIAVEKVCEFIEENFPSADCLAVSGNMCSDKKQTNVNSL 237
Query: 244 LGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYG-FNAHFGNIVGA 302
GRGKTV+AEA++ ++++ L + +LI ++N KN +G+A+AGS FNAHF NIV A
Sbjct: 238 FGRGKTVLAEALIKKDVIRNILHSNAQLIHDINLRKNWLGTARAGSLSQFNAHFANIVTA 297
Query: 303 IFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIM 362
IF+ATGQD AQI E S G T EV E DLYIS+T+PSLE+GTVGGGTR+PTQ+EALSIM
Sbjct: 298 IFIATGQDVAQIVESSSGYTWTEVRGE-DLYISVTLPSLEVGTVGGGTRLPTQKEALSIM 356
Query: 363 GVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
GV G G+PPG NAKK AEI+A VL+GEL+LLAA++ K L +AH LGR
Sbjct: 357 GVYGSGNPPGSNAKKLAEIIASTVLSGELNLLAALSNKELGKAHAKLGR 405
>sp|O26662|HMDH_METTH 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|7447706|pir||D69174 3-hydroxy-3-methylglutaryl CoA
reductase - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2621639|gb|AAB85068.1| (AE000839)
3-hydroxy-3-methylglutaryl CoA reductase
[Methanobacterium thermoautotrophicum]
Length = 397
Score = 437 bits (1113), Expect = e-122
Identities = 229/404 (56%), Positives = 290/404 (71%), Gaps = 11/404 (2%)
Query: 9 IIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGRNI 68
I++ + G IKL+++E++V D+ A IRR+ +ER G+ L+H+ +YSID RNI
Sbjct: 3 IMDDLMEGRIKLYEIERHVPVDE--AVRIRREFIERTCGVKLEHVSNYSIDMERASRRNI 60
Query: 69 ENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTI 128
EN IGVVQIP+GVAGPL++ GE+A GE+Y+PLAT+EGALVASVNRGCS +T AGG +
Sbjct: 61 ENPIGVVQIPLGVAGPLRVRGEHADGEYYVPLATSEGALVASVNRGCSVITRAGGATVRV 120
Query: 129 LDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIV-GNNL 187
D MTRAP+IR + A ++ EW+ EN++ L+E+A TRHGKL + P IV G+ +
Sbjct: 121 TGDSMTRAPVIRTGSVVEALQLREWIYENMDALREEA-ESTTRHGKLVKIDPIIVAGSYV 179
Query: 188 YLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRG 247
Y RF + TGD+MGMNMVTIA+E ++++ E +ALSGNLC DKKP AVN I GRG
Sbjct: 180 YPRFVYTTGDSMGMNMVTIATERALELLTRE-TGAHVIALSGNLCTDKKPAAVNLIEGRG 238
Query: 248 KTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIFLAT 307
K++ AE VP E+VE LKTTPE + EVN KNL+GSA AGS GFNAH+ NI+GAIFLAT
Sbjct: 239 KSITAEITVPGEMVESVLKTTPEAVVEVNTAKNLIGSAAAGSMGFNAHYANIIGAIFLAT 298
Query: 308 GQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGG 367
GQDEA I EGS G+TIAE +GDLY ++ +P + + TVGGGT + T E L IMGV GG
Sbjct: 299 GQDEAHIVEGSLGVTIAE-ERKGDLYFAVNLPDVPLATVGGGTGLETASECLDIMGVRGG 357
Query: 368 GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
G FAEIV GAVLAGELSL+ A+AA HLARAH LGR
Sbjct: 358 G-----RVHAFAEIVGGAVLAGELSLMGALAAGHLARAHSELGR 396
>sp|Q59468|HMDH_HALVO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|419713|pir||A42149 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) [validated] - Haloferax
volcanii >gi|149027|gb|AAA73174.1| (M83531)
3-hydroxy-3-methylglutaryl coenzyme A reductase
[Haloferax volcanii]
Length = 403
Score = 420 bits (1067), Expect = e-116
Identities = 212/403 (52%), Positives = 286/403 (70%), Gaps = 6/403 (1%)
Query: 9 IIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGRNI 68
+ ++V G+++LH++E + + D A E RR +E + G SL +G+Y P E I
Sbjct: 7 LADRVREGDLRLHELEAHADADT--AAEARRLLVESQSGASLDAVGNYGF-PAEAAESAI 63
Query: 69 ENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTI 128
ENM+G +Q+PMGVAGP+ ++G GE Y+PLATTEGAL+ASVNRGCS + AGG +
Sbjct: 64 ENMVGSIQVPMGVAGPVSVDGGSVAGEKYLPLATTEGALLASVNRGCSVINSAGGATARV 123
Query: 129 LDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLY 188
L MTRAP+ R + A + W ++N L+E A + T HG+L DV P++VGN++Y
Sbjct: 124 LKSGMTRAPVFRVADVAEAEALVSWTRDNFAALKE-AAEETTNHGELLDVTPYVVGNSVY 182
Query: 189 LRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGK 248
LRF ++T DAMGMNM TIA+E + V+E E +ALSGNLC DKKP A+N + GRG+
Sbjct: 183 LRFRYDTKDAMGMNMATIATEAVCGVVEAETA-ASLVALSGNLCSDKKPAAINAVEGRGR 241
Query: 249 TVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIFLATG 308
+V A+ +PRE+VE++L TTPE E+N KNLVGSA+A S GFNAH N+V A+FLATG
Sbjct: 242 SVTADVRIPREVVEERLHTTPERGRELNTRKNLVGSAKAASLGFNAHVANVVAAMFLATG 301
Query: 309 QDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGG 368
QDEAQ+ EG++ IT AEV +GDLY+S+++ SLE+GTVGGGT++PTQ E L I+GV+GGG
Sbjct: 302 QDEAQVVEGANAITTAEV-QDGDLYVSVSIASLEVGTVGGGTKLPTQSEGLDILGVSGGG 360
Query: 369 DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
DP G NA AE +A LAGELSLL+A+A++HL+ AH LGR
Sbjct: 361 DPAGSNADALAECIAVGSLAGELSLLSALASRHLSSAHAELGR 403
>gb|AAG20075.1| (AE005087) 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MvaA
[Halobacterium sp. NRC-1]
Length = 405
Score = 404 bits (1026), Expect = e-111
Identities = 199/407 (48%), Positives = 279/407 (67%), Gaps = 5/407 (1%)
Query: 5 NVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELI 64
+ D+ ++V G+++L++++ + D A RR LER+ +G ++ D ++
Sbjct: 4 DASDLADRVQAGDLRLYELDDETDADTAAAA--RRAVLERETDADTDALGAFAFDADQAA 61
Query: 65 GRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGV 124
+EN+ G Q+P+GVAGP+ ++G A GE+Y+P+ATTEGALVASVNRGCSA+T AGG
Sbjct: 62 DTAVENLTGGAQLPLGVAGPVALSGGAADGEYYLPMATTEGALVASVNRGCSAITAAGGA 121
Query: 125 VTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVG 184
+ MTRAP+ R + EVA+W +N + L A T HG+L DV P++VG
Sbjct: 122 NARVTKTGMTRAPVFRVADVTEGAEVAQWADDNTDALAA-AAESTTSHGELTDVTPYVVG 180
Query: 185 NNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFIL 244
+N+YLRF ++T DAMGMNM TIA+E +++E+E P +A+SGNLC DKKP A+N +
Sbjct: 181 DNVYLRFRYDTKDAMGMNMATIATEAASELVEDETP-AELVAVSGNLCTDKKPAAINAVE 239
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIF 304
GRG+TV A+ +P+++VE++ TTP I E N KNL+GSA+AGS GFNAH N+V A+F
Sbjct: 240 GRGRTVTADVTIPQDVVEERFDTTPAAIEEANTRKNLIGSAKAGSLGFNAHAANVVAAVF 299
Query: 305 LATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGV 364
LATGQD AQ+ EG++ IT E + LY S+ + SLE+GTVGGGT +PTQREAL ++GV
Sbjct: 300 LATGQDAAQVVEGANAITTVEARDDA-LYASVNLASLEVGTVGGGTTLPTQREALDVLGV 358
Query: 365 AGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
GGGDP G NA AEI+A LAGE++LLAA+A++ L+ AH LGR
Sbjct: 359 RGGGDPAGANADALAEIIAVGALAGEINLLAALASRRLSAAHADLGR 405
>gb|AAG35211.1|AF123438_1 (AF123438) 3-hydroxy-3-methylglutaryl coenzyme A reductase
[Haloarcula hispanica]
Length = 405
Score = 377 bits (957), Expect = e-103
Identities = 197/404 (48%), Positives = 274/404 (67%), Gaps = 8/404 (1%)
Query: 9 IIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGRNI 68
+ E+V +GE++L+++E + + D A RR L + G L +G Y+ D + NI
Sbjct: 9 LAERVRDGELRLYELEDHADPDTAAAA--RRHLLAEETGADLSAVGDYTFDAADAES-NI 65
Query: 69 ENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTI 128
ENM+G VQ+PMGV GPL ++G A+G+ ++PLAT+EGAL+ASVNRG S + AGG +
Sbjct: 66 ENMVGAVQVPMGVVGPLPVDGGAAEGDHHLPLATSEGALLASVNRGVSTIRNAGGATARV 125
Query: 129 LDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLY 188
L MTRAP+ R + +A EV+ WV+E+++ L + A T HG+L+DV P++VG++++
Sbjct: 126 LKSGMTRAPVFRVEDVAKAGEVSAWVREHVDVLAD-AAESTTSHGELQDVTPYVVGDSVF 184
Query: 189 LRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGK 248
LRF ++T DAMGMNM TIA+E V+E E P +ALSGNLC DKKP A+N + GRG+
Sbjct: 185 LRFSYDTKDAMGMNMATIATEAACDVVESETP-ADLVALSGNLCSDKKPAAINAVEGRGR 243
Query: 249 TVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIFLATG 308
TV A+ ++P E VE++L TT + I E N KNLVGSA+AG+ GFNAH N+V A FLA G
Sbjct: 244 TVAADVLIPHEQVEERLDTTSDAIVEANTRKNLVGSAKAGALGFNAHTANVVAAAFLALG 303
Query: 309 QDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMG-VAGG 367
QD AQ+ EG++ IT + +G LY S+T+P LE+G VG G R P L + G GG
Sbjct: 304 QDIAQVVEGNNAITTVDAREDG-LYASVTIPFLEVGNVGRG-RFPEAFGGLEVGGDNGGG 361
Query: 368 GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
GDP G NA+ E++AG LAGELSLLAA++++HL+ AH LGR
Sbjct: 362 GDPAGSNAEALGEVIAGGALAGELSLLAALSSRHLSSAHAELGR 405
>gb|AAA68966.1| (U14625) 3-hydroxy-3-methylglutaryl coenzyme A reductase [Artemisia
annua]
Length = 560
Score = 362 bits (920), Expect = 3e-99
Identities = 196/412 (47%), Positives = 276/412 (66%), Gaps = 10/412 (2%)
Query: 5 NVEDIIEK-VANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNEL 63
N +D+I K V +GE+ + +E + GD A +IRR+A+ER +G + +G D +
Sbjct: 142 NDDDVIVKSVVSGEVNSYSLEASL-GDCYRAAKIRRRAVERIVGREVLGLGFEGFDYESI 200
Query: 64 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 123
+G+ E IG VQ+P+GVAGPL +NG GEF +P+ATTEG LVAS NRGC A+ +GG
Sbjct: 201 LGQCCEMPIGYVQVPVGVAGPLLLNG----GEFMVPMATTEGCLVASTNRGCKAICLSGG 256
Query: 124 VVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFI 182
+L D MTRAP++R A RA ++ ++++ +N+ V K +R +L++++ I
Sbjct: 257 ATAILLKDGMTRAPVVRFATAERASQLKFYLEDGVNFDTLSVVFNKSSRFARLQNIQCSI 316
Query: 183 VGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNF 242
G NLY+RF TGDAMGMNMV+ + ++ ++ +FPD+ + +SGN C DKKP AVN+
Sbjct: 317 AGKNLYIRFTCSTGDAMGMNMVSKGVQNVLDFLQNDFPDMDVIGISGNFCSDKKPAAVNW 376
Query: 243 ILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVG 301
I GRGK+VV EA++ E+V K LKTT + E+N KNL GSA AGS GFNAH NIV
Sbjct: 377 IEGRGKSVVCEAVITEEVVRKVLKTTVPALVELNMLKNLTGSAIAGSLGGFNAHAANIVS 436
Query: 302 AIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+F+ATGQD AQ E SH IT+ E G DL++S+TMPS+E+GTVGGGT++ +Q L+
Sbjct: 437 AVFIATGQDPAQNIESSHCITMMEAVNNGKDLHVSVTMPSIEVGTVGGGTQLASQSACLN 496
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GV G + PG NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 497 LLGVKGACIESPGSNAQLLARIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 548
>gb|AAA68965.1| (U14624) 3-hydroxy-3-methylglutaryl coenzyme A reductase [Artemisia
annua]
Length = 566
Score = 362 bits (920), Expect = 3e-99
Identities = 196/412 (47%), Positives = 276/412 (66%), Gaps = 10/412 (2%)
Query: 5 NVEDIIEK-VANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNEL 63
N +D+I K V +GE+ + +E + GD A +IRR+A+ER +G + +G D +
Sbjct: 148 NDDDVIVKSVVSGEVNSYSLEASL-GDCYRAAKIRRRAVERIVGREVLGLGFEGFDYESI 206
Query: 64 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 123
+G+ E IG VQ+P+GVAGPL +NG GEF +P+ATTEG LVAS NRGC A+ +GG
Sbjct: 207 LGQCCEMPIGYVQVPVGVAGPLLLNG----GEFMVPMATTEGCLVASTNRGCKAICLSGG 262
Query: 124 VVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFI 182
+L D MTRAP++R A RA ++ ++++ +N+ V K +R +L++++ I
Sbjct: 263 ATAILLKDGMTRAPVVRFATAERASQLKFYLEDGVNFDTLSVVFNKSSRFARLQNIQCSI 322
Query: 183 VGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNF 242
G NLY+RF TGDAMGMNMV+ + ++ ++ +FPD+ + +SGN C DKKP AVN+
Sbjct: 323 AGKNLYIRFTCSTGDAMGMNMVSKGVQNVLDFLQNDFPDMDVIGISGNFCSDKKPAAVNW 382
Query: 243 ILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVG 301
I GRGK+VV EA++ E+V K LKTT + E+N KNL GSA AGS GFNAH NIV
Sbjct: 383 IEGRGKSVVCEAVITEEVVRKVLKTTVPALVELNMLKNLTGSAIAGSLGGFNAHAANIVS 442
Query: 302 AIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+F+ATGQD AQ E SH IT+ E G DL++S+TMPS+E+GTVGGGT++ +Q L+
Sbjct: 443 AVFIATGQDPAQNIESSHCITMMEAVNNGKDLHVSVTMPSIEVGTVGGGTQLASQSACLN 502
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GV G + PG NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 503 LLGVKGACIESPGSNAQLLARIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 554
>sp|Q9XHL5|HMD3_ORYSA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 3 (HMG-COA
REDUCTASE 3) >gi|5059025|gb|AAD38873.1|AF110382_1
(AF110382) 3-hydroxy-3-methylglutaryl-coenzyme A
reductase [Oryza sativa]
Length = 560
Score = 359 bits (911), Expect = 4e-98
Identities = 190/409 (46%), Positives = 276/409 (67%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I+ V G++ + +E + GD R A IRR+A+ R G ++ + D ++G+
Sbjct: 147 EEIVSSVVAGKVPSYVLETKL-GDCRRAAGIRREAVRRITGRQIEGLPLDGFDYASILGQ 205
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQ+P+G+AGPL ++G+ FY+P+ATTEG LVAS NRGC A+ E+GG V+
Sbjct: 206 CCELPVGYVQLPVGIAGPLLLDGQ----RFYVPMATTEGCLVASTNRGCKAIAESGGAVS 261
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP+ R P ARRA E+ ++++++N+ V + +R +L+ V+ + G
Sbjct: 262 VVLRDGMTRAPVARLPTARRAAELKAFLEDSVNFNTLSMVFNRSSRFARLQGVQCAMAGR 321
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++++FPD+ +++SGN C DKKP AVN+I G
Sbjct: 322 NLYMRFSCCTGDAMGMNMVSKGEQNVLDYLQDDFPDMDVISISGNFCSDKKPAAVNWIEG 381
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ ++V+K LKT + + E+N KNL GSA AG+ GFNAH NIV AIF
Sbjct: 382 RGKSVVCEAVIKEDVVKKVLKTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVTAIF 441
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L ++G
Sbjct: 442 IATGQDPAQNVESSHCITMLEAVNDGRDLHISVTMPSIEVGTVGGGTQLASQAACLDLLG 501
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA+ A +VAG VLAGELSLL+A+ A L ++H R
Sbjct: 502 VKGANRESPGSNARLLATVVAGGVLAGELSLLSALRAGQLVKSHMKYNR 550
>pir||T03382 probable hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34)
- rice >gi|1154889|emb|CAA92821.1| (Z68504)
3-hydroxy-3-methylglutaryl-CoA reductase [Oryza sativa]
>gi|1171364|gb|AAD08820.1| (U43961)
3-hydroxy-3-methylglutaryl=CoA reductase [Oryza sativa]
Length = 576
Score = 358 bits (910), Expect = 5e-98
Identities = 194/409 (47%), Positives = 274/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I+ +V G+I + +E + GD R A IRR+A+ R G ++ + D ++G+
Sbjct: 163 EEIVAEVVAGKIPSYVLETRL-GDCRRAAGIRREAVRRTTGREIRGLPLDGFDYASILGQ 221
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQ+P+GVAGPL ++GE FY+P+ATTEG LVAS NRGC A+ E+GG +
Sbjct: 222 CCELPVGYVQLPVGVAGPLVLDGE----RFYVPMATTEGCLVASTNRGCKAIAESGGATS 277
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP+ R P+ARRA E+ +++ N+ V + +R +L+ VK + G
Sbjct: 278 VVLQDGMTRAPVARFPSARRAAELKGFLENPANFDTLAMVFNRSSRFARLQRVKCAVAGR 337
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++++FPD+ +++SGN C DKK AVN+I G
Sbjct: 338 NLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQDDFPDMDVISISGNFCSDKKSAAVNWIEG 397
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ E+V+K LKT + + E+N KNL GSA AG+ GFNAH NIV AIF
Sbjct: 398 RGKSVVCEAVIKEEVVKKVLKTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVTAIF 457
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E S IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L ++G
Sbjct: 458 IATGQDPAQNVESSQCITMLEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLDLLG 517
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA+ A +VAGAVLAGELSL++A AA HL ++H R
Sbjct: 518 VKGANRESPGSNARLLAAVVAGAVLAGELSLISAQAAGHLVQSHMKYNR 566
>sp|Q41438|HMD3_SOLTU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 3 (HMG-COA
REDUCTASE 3) (HMG3.3) >gi|7431195|pir||T07112
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) (clone hmg3.3) - potato
>gi|1245486|gb|AAB52552.1| (U51986) HMG-CoA reductase
[Solanum tuberosum] >gi|7415990|dbj|BAA93631.1|
(AB022690) 3-hydroxy-3-methylglutaryl coenzyme A
reductase [Solanum tuberosum]
Length = 574
Score = 357 bits (907), Expect = 1e-97
Identities = 192/409 (46%), Positives = 275/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E +I+ V G I + +E + GD + A IR++AL+R G SL+ + D ++G+
Sbjct: 164 EVVIKSVVEGRIPSYSLESKL-GDCKRAAFIRKEALQRSSGKSLEGLPLDGFDYESILGQ 222
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG +QIP+G+AGPL +NG+ EF +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 223 CCEMPIGYIQIPVGIAGPLLLNGK----EFSVPMATTEGCLVASTNRGCKAIYVSGGATS 278
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+ D MTRAP++R +A+RA E+ +V++ +N+ V K +R +L++++ I G
Sbjct: 279 VLFRDAMTRAPVVRFGSAKRAAELKFFVEDPMNFETLSVVFNKSSRFARLQNIQCAIAGK 338
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+I G
Sbjct: 339 NLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDIIGISGNYCSDKKPAAVNWIEG 398
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ ++V+K LKT + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 399 RGKSVVCEAIIKEDVVKKVLKTEVATLVELNMLKNLTGSAMAGALGGFNAHASNIVSAVY 458
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
LATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 459 LATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 518
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 519 VKGANREAPGSNARLLATIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 567
>pir||T04302 probable hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34)
- rice (fragment) >gi|2072322|gb|AAB53748.1| (U95816)
Isolation and Characterization of a cDNA Encoding
3-Hydroxy-3-Methylglutaryl-CoA Reductase from Rice
[Oryza sativa]
Length = 495
Score = 357 bits (906), Expect = 1e-97
Identities = 194/409 (47%), Positives = 273/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I+ +V G+I + +E + GD R A IRR+A+ R G ++ + D ++G+
Sbjct: 82 EEIVAEVVAGKIPSYVLETRL-GDCRRAAGIRREAVRRTTGREIRGLPLDGFDYASILGQ 140
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQ+P+GVAGPL ++GE FY+P+ATTEG LVAS NRGC A+ E+GG +
Sbjct: 141 CCELPVGYVQLPVGVAGPLVLDGE----RFYVPMATTEGCLVASTNRGCKAIAESGGATS 196
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP+ R P+ARRA E+ +++ N V + +R +L+ VK + G
Sbjct: 197 VVLQDGMTRAPVARFPSARRAAELKGFLENPANVDTLAMVFNRSSRFARLQRVKCAVAGR 256
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++++FPD+ +++SGN C DKK AVN+I G
Sbjct: 257 NLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQDDFPDMDVISISGNFCSDKKSAAVNWIEG 316
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ E+V+K LKT + + E+N KNL GSA AG+ GFNAH NIV AIF
Sbjct: 317 RGKSVVCEAVIKEEVVKKVLKTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVTAIF 376
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E S IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L ++G
Sbjct: 377 IATGQDPAQNVESSQCITMLEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLDLLG 436
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA+ A +VAGAVLAGELSL++A AA HL ++H R
Sbjct: 437 VKGANRESPGSNARLLAAVVAGAVLAGELSLISAQAAGHLVQSHMKYNR 485
>sp|P14891|HMD1_ARATH 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1 (HMG-COA
REDUCTASE 1) (HMGR1) >gi|99714|pir||A32107
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) - Arabidopsis thaliana
>gi|16336|emb|CAA33139.1| (X15032) hydroxy
methylglutaryl CoA reductase (AA 1-592) [Arabidopsis
thaliana] >gi|166750|gb|AAA76821.1| (J04537)
3-hydroxy-3-methylglutaryl CoA reductase [Arabidopsis
thaliana] >gi|388556|gb|AAA32814.1| (L19261)
hydroxymethylglutaryl CoA reductase [Arabidopsis
thaliana] >gi|6554470|gb|AAF16652.1|AC012394_1
(AC012394) hydroxy methylglutaryl CoA reductase (AA
1-592); 9510-7255 [Arabidopsis thaliana]
>gi|6642667|gb|AAF20247.1|AC015450_8 (AC015450)
3-hydroxy-3-methylglutaryl CoA reductase (AA 1-592);
32253-34508 [Arabidopsis thaliana]
Length = 592
Score = 356 bits (905), Expect = 2e-97
Identities = 196/410 (47%), Positives = 276/410 (66%), Gaps = 11/410 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I++ V +G I + +E + GD + A IRR+AL+R G S++ + D ++G+
Sbjct: 173 EEIVKSVIDGVIPSYSLESRL-GDCKRAASIRREALQRVTGRSIEGLPLDGFDYESILGQ 231
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G +QIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 232 CCEMPVGYIQIPVGIAGPLLLDGY----EYSVPMATTEGCLVASTNRGCKAMFISGGATS 287
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA--KVTRHGKLRDVKPFIVG 184
T+L D MTRAP++R +ARRA E+ ++ EN AV + +R +L+ VK I G
Sbjct: 288 TVLKDGMTRAPVVRFASARRASEL-KFFLENPENFDTLAVVFNRSSRFARLQSVKCTIAG 346
Query: 185 NNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFIL 244
N Y+RF TGDAMGMNMV+ + +++ + ++FPD+ + +SGN C DKKP AVN+I
Sbjct: 347 KNAYVRFCCSTGDAMGMNMVSKGVQNVLEYLTDDFPDMDVIGISGNFCSDKKPAAVNWIE 406
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAI 303
GRGK+VV EA++ EIV K LKT+ + E+N KNL GSA AGS GFNAH NIV A+
Sbjct: 407 GRGKSVVCEAVIRGEIVNKVLKTSVAALVELNMLKNLAGSAVAGSLGGFNAHASNIVSAV 466
Query: 304 FLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIM 362
F+ATGQD AQ E S IT+ E +G D++IS+TMPS+E+GTVGGGT++ +Q L+++
Sbjct: 467 FIATGQDPAQNVESSQCITMMEAINDGKDIHISVTMPSIEVGTVGGGTQLASQSACLNLL 526
Query: 363 GVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
GV G + PG+NA++ A IVAGAVLAGELSL++AIAA L R+H R
Sbjct: 527 GVKGASTESPGMNARRLATIVAGAVLAGELSLMSAIAAGQLVRSHMKYNR 576
>sp|O64967|HMD2_GOSHI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2 (HMG-COA
REDUCTASE 2) >gi|7431201|pir||T09785
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) 2 - upland cotton >gi|2935300|gb|AAC05089.1|
(AF038046) 3-hydroxy-3-methylglutaryl-coenzyme A
reductase 2 [Gossypium hirsutum]
Length = 628
Score = 356 bits (904), Expect = 3e-97
Identities = 194/409 (47%), Positives = 272/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G + + +E + GD + A IRR+AL+R G SL + D ++G+
Sbjct: 215 EEIIKSVVAGTLPSYSLESKL-GDCKRAAAIRREALQRLTGRSLSGLPLDGFDYESILGQ 273
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL +NG E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 274 CCEMPVGYVQIPVGIAGPLLLNGR----EYSVPMATTEGCLVASTNRGCKAIHLSGGATS 329
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R A+RA E+ ++++ N+ V + +R G+L+ +K I G
Sbjct: 330 ILLKDGMTRAPVVRFSTAKRAAELKFYLEDPENFDTLAVVFNRSSRFGRLQSIKCAIAGK 389
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLYLRF TGDAMGMNMV+ + ++ ++ +FPD+ + +SGN C DKKP AVN+I G
Sbjct: 390 NLYLRFTCSTGDAMGMNMVSKGVQNVLDFLQTDFPDMDVIGISGNFCSDKKPAAVNWIEG 449
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ ++V K LKT+ E + E+N KNL GSA AG+ GFNAH NIV AI+
Sbjct: 450 RGKSVVCEAIIEGDVVRKVLKTSVESLVELNMLKNLTGSAMAGALGGFNAHASNIVTAIY 509
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 510 IATGQDPAQNVESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 569
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G D G N++ A IV GAVLAGELSL++A+AA L ++H R
Sbjct: 570 VKGASKDVAGANSRMLATIVTGAVLAGELSLMSALAAGQLVKSHMKYNR 618
>sp|P48021|HMDH_CAMAC 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|289881|gb|AAA33040.1| (L10390)
3-hydroxy-3-methylglutaryl coA reductase [Camptotheca
acuminata]
Length = 593
Score = 356 bits (903), Expect = 3e-97
Identities = 191/409 (46%), Positives = 272/409 (65%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G + +E + GD A IRR+AL+R SL + D + ++G+
Sbjct: 180 EEIIKSVVEGTTPSYALESKL-GDSHRAAAIRREALQRMTKKSLAGLPLDGFDYDSILGQ 238
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ GG +
Sbjct: 239 CCEMPVGYVQIPVGIAGPLLLDGR----EYSVPMATTEGCLVASTNRGCKAIFACGGATS 294
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVT-RHGKLRDVKPFIVGN 185
+L D MTRAP++R +A+RA ++ +++ LN+ AV + R GKL+++K I G
Sbjct: 295 VLLRDAMTRAPVVRFGSAKRAADLKFFLENPLNFETLAAVFNSSSRFGKLQNIKCAIAGK 354
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+R+ TGDAMGMNM++ + ++ ++++FPD+ + +SGN C DKKP AVN+I G
Sbjct: 355 NLYMRYSCSTGDAMGMNMISKGVQNVLDFLQDDFPDMDVIGISGNYCSDKKPAAVNWIEG 414
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 415 RGKSVVCEAVIKEEVVKKVLKTNVASLVELNMLKNLTGSAMAGALGGFNAHASNIVSAVY 474
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
LATGQD AQ E SH IT+ E +G DL++S+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 475 LATGQDPAQNVESSHCITMMEAINDGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLG 534
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA+ A IVAG+VLAGELSL++AIAA L +H R
Sbjct: 535 VKGASKEAPGSNARLLATIVAGSVLAGELSLMSAIAAGQLVNSHMKYNR 583
>pir||T04120 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - common
tobacco >gi|2654423|gb|AAB87727.1| (U60452)
hydroxy-methylglutaryl-coenzyme A reductase [Nicotiana
tabacum]
Length = 604
Score = 356 bits (903), Expect = 3e-97
Identities = 192/409 (46%), Positives = 274/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G+ + +E + KR A+ +RR+AL+R G SL+ + D ++G+
Sbjct: 191 EEIIQSVVQGKTPSYSLESKLADCKRAAS-VRREALQRITGKSLEGLPLEGFDYESILGQ 249
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG ++
Sbjct: 250 CCEMPVGYVQIPVGIAGPLLLDGR----EYSVPMATTEGCLVASTNRGCKAIFASGGAIS 305
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R A+RA E+ +V++ LN+ V K +R +L+ ++ I G
Sbjct: 306 VLLRDGMTRAPVVRFATAKRAAELKFFVEDPLNFETLSLVFNKSSRFARLQSIQCAIAGK 365
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+I G
Sbjct: 366 NLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVNWIEG 425
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 426 RGKSVVCEAIITEEVVKKVLKTEVASLVELNVLKNLTGSAMAGALGGFNAHASNIVSAVY 485
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
LATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 486 LATGQDPAQNVESSHCITMIEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 545
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + G NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 546 VKGANREAAGSNARLLATIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 594
>sp|Q03163|HMDH_CATRO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|7431205|pir||T09967 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - Madagascar periwinkle
>gi|167488|gb|AAA33108.1| (M96068)
hydroxymethylglutaryl-CoA reductase [Catharanthus
roseus] >gi|445621|prf||1909368A hydroxy methylglutaryl
CoA reductase [Catharanthus roseus]
Length = 601
Score = 355 bits (902), Expect = 4e-97
Identities = 196/409 (47%), Positives = 273/409 (65%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
EDII+ V G+I + +E + GD + A IRR+AL+R G SL+ + D ++G+
Sbjct: 181 EDIIKAVVAGKIPSYSLESKL-GDCKRAAGIRREALQRITGKSLEGLPLEGFDYASILGQ 239
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQ+P+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 240 CCEMPVGYVQLPVGIAGPLLLDGR----EYMLPMATTEGCLVASTNRGCKAILASGGANS 295
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R A+RA E+ ++++ N+ V K +R KL+ V+ I G
Sbjct: 296 VLLRDGMTRAPVVRFGTAKRAAELKFYMEDTQNFETISVVFNKSSRFAKLQSVQCAIAGK 355
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + +++ ++ ++PD+ L +SGN C DKKP AVN+I G
Sbjct: 356 NLYIRFSCSTGDAMGMNMVSKGVQNVLEFLQTDYPDMDVLGISGNFCADKKPAAVNWIEG 415
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ EIV+ LKT + E+N KNL GSA AG+ GFNAH NIV AIF
Sbjct: 416 RGKSVVCEAIIKEEIVKTVLKTEVAALIELNMVKNLAGSAIAGALGGFNAHASNIVSAIF 475
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E S IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 476 IATGQDPAQNVESSQCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 535
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G D PG N++ A IVAG+VLAGELSL++AI+A L R+H R
Sbjct: 536 VKGASKDSPGANSRLLATIVAGSVLAGELSLMSAISAGQLVRSHMKYNR 584
>sp|O24594|HMDH_MAIZE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|7431199|pir||T04357 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - maize
>gi|1667389|emb|CAA70440.1| (Y09238)
3-hydroxy-3-methylglutaryl coenzyme A reductase [Zea
mays]
Length = 579
Score = 355 bits (902), Expect = 4e-97
Identities = 193/409 (47%), Positives = 272/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I+ V G++ + +E + GD R A IRR+AL R G ++ + D ++G+
Sbjct: 155 EEIVASVVAGKVPSYALEARL-GDCRRAAGIRREALRRITGRDIEGLPLDGFDYASILGQ 213
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQ+P+GVAGPL ++G FY+P+ATTEG LVAS NRGC A+ E+GG +
Sbjct: 214 CCELPVGYVQLPVGVAGPLLLDGR----RFYLPMATTEGCLVASTNRGCKAIAESGGATS 269
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP+ R P ARRA E+ ++++ N+ V + +R +L+ V+ + G
Sbjct: 270 VVLRDAMTRAPVARFPTARRAAELKAFLEDPANFDTLSVVFNRSSRFARLQGVQCAMAGR 329
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++++F D+ +++SGN C DKKP+AVN+I G
Sbjct: 330 NLYMRFSCSTGDAMGMNMVSKGVQNVLDFLQDDFHDMDVISISGNFCSDKKPSAVNWIEG 389
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ E+V+K LKT + + E+N KNL GSA AG+ GFNAH NIV AIF
Sbjct: 390 RGKSVVCEAVIGEEVVKKVLKTDVQSLVELNTIKNLAGSAVAGALGGFNAHASNIVTAIF 449
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E G DL+IS+TMPS+E+GTVGGGT++ +Q L ++G
Sbjct: 450 IATGQDPAQNVESSHCITMLEPVNAGRDLHISVTMPSIEVGTVGGGTQLASQSACLDLLG 509
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G D PG NA+ A +VAG VLAGELSLL+A+AA L ++H R
Sbjct: 510 VRGASRDRPGSNARLLATVVAGGVLAGELSLLSALAAGQLVKSHMKYNR 558
>sp|P29057|HMD1_HEVBR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1 (HMG-COA
REDUCTASE 1) >gi|280399|pir||S14955
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) 1 - Para rubber tree >gi|18833|emb|CAA38467.1|
(X54657) hydroxymethylglutaryl-CoA reductase [Hevea
brasiliensis] >gi|18835|emb|CAA38469.1| (X54659)
hydroxymethylglutaryl-CoA reductase [Hevea brasiliensis]
Length = 575
Score = 354 bits (899), Expect = 1e-96
Identities = 194/409 (47%), Positives = 273/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E I+ V +G+I + +E + GD + A IRR+AL+R SL+ + D ++G+
Sbjct: 162 EMIVNSVVDGKIPSYSLESKL-GDCKRAAAIRREALQRMTRRSLEGLPVEGFDYESILGQ 220
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL +NG E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 221 CCEMPVGYVQIPVGIAGPLLLNGR----EYSVPMATTEGCLVASTNRGCKAIYLSGGATS 276
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R +A RA E+ ++++ N+ V K +R +L+ +K I G
Sbjct: 277 VLLKDGMTRAPVVRFASATRAAELKFFLEDPDNFDTLAVVFNKSSRFARLQGIKCSIAGK 336
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + +++ ++ +F D+ + +SGN C DKKP AVN+I G
Sbjct: 337 NLYIRFSCSTGDAMGMNMVSKGVQNVLEFLQSDFSDMDVIGISGNFCSDKKPAAVNWIEG 396
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH GNIV AIF
Sbjct: 397 RGKSVVCEAIIKEEVVKKVLKTNVASLVELNMLKNLAGSAVAGALGGFNAHAGNIVSAIF 456
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 457 IATGQDPAQNVESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 516
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG N++ A IVAG+VLAGELSL++AIAA L ++H R
Sbjct: 517 VKGANKESPGSNSRLLAAIVAGSVLAGELSLMSAIAAGQLVKSHMKYNR 565
>sp|P48020|HMD1_SOLTU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1 (HMG-COA
REDUCTASE 1) (HMGR1) (HMGR) >gi|2117465|pir||S59944
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) - potato >gi|169485|gb|AAA93498.1| (L01400)
hydroxymethylglutaryl coenzyme A reductase [Solanum
tuberosum]
Length = 596
Score = 354 bits (899), Expect = 1e-96
Identities = 191/409 (46%), Positives = 273/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G+ + +E + GD A IR++AL+R G SL+ + D + ++G+
Sbjct: 186 EEIIQSVVQGKTPSYSLESKL-GDCMRAASIRKEALQRITGKSLEGLPLEGFDYSSILGQ 244
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 245 CCEMPVGYVQIPVGIAGPLLLDGR----EYSVPMATTEGCLVASTNRGCKAIFVSGGADS 300
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R A+RA E+ +V++ LN+ + K +R +L+ ++ I G
Sbjct: 301 VLLRDGMTRAPVVRFTTAKRAAELKFFVEDPLNFETLSLMFNKSSRFARLQGIQCAIAGK 360
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+ F TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+I G
Sbjct: 361 NLYITFSCSTGDAMGMNMVSKGVQNVLDYLQSEYPDMDVIGISGNFCSDKKPAAVNWIEG 420
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 421 RGKSVVCEAIIKEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVY 480
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
LATGQD AQ E SH IT+ E +G DL++S+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 481 LATGQDPAQNVESSHCITMMEAVNDGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLG 540
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G D PG NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 541 VKGANRDAPGSNARLLATIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 589
>pir||S59946 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - potato
(fragment)
Length = 501
Score = 354 bits (899), Expect = 1e-96
Identities = 191/409 (46%), Positives = 273/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E +I+ V G I + +E + GD + A IR++AL+R G SL+ + D ++G+
Sbjct: 91 EVVIKSVVEGRIPSYSLESKL-GDCKRAAFIRKEALQRSSGKSLEGLPLDGFDYESILGQ 149
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG +QIP+G+AGPL +NG+ EF +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 150 CCEMPIGYIQIPVGIAGPLLLNGK----EFSVPMATTEGCLVASTNRGCKAIYVSGGATS 205
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+ D MTRAP++R +A+RA E+ +V++ +N+ V K +R +L++++ I G
Sbjct: 206 VLFRDAMTRAPVVRFGSAKRAAELKFFVEDPMNFETLSVVFNKSSRFARLQNIECAIAGK 265
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+I G
Sbjct: 266 NLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDIIGISGNYCSDKKPAAVNWIEG 325
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK VV EAI+ ++V+K LKT + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 326 RGKLVVCEAIIKEDVVKKVLKTEVATLVELNMLKNLTGSAMAGALGGFNAHASNIVSAVY 385
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
LAT QD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 386 LATAQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 445
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 446 VKGANREAPGSNARLLATIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 494
>dbj|BAA36291.1| (AB021862) HMG-CoA reductase [Cucumis melo]
Length = 587
Score = 353 bits (897), Expect = 2e-96
Identities = 189/409 (46%), Positives = 273/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E++++ V +G + + +E + GD + A IRR+AL+R G S+ + D ++G+
Sbjct: 174 EEVVKMVVDGSVPSYSLESKL-GDPKRAASIRREALQRTTGRSIHGLPFEGFDYESILGQ 232
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 233 CCEMPVGYVQIPVGIAGPLLLDGF----EYTVPMATTEGCLVASTNRGCKAIYASGGATS 288
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R +A+RA E+ ++++ N+ V + +R +L+ ++ I G
Sbjct: 289 MLLKDGMTRAPVVRFGSAKRASELKFFLEDPSNFDTLAVVFNRSSRFARLQSIRCSIAGK 348
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + +++ ++ +F D+ + +SGN C DKKP AVN+I G
Sbjct: 349 NLYVRFCCSTGDAMGMNMVSKGVQNVLEFLQHDFSDMEVIGISGNFCADKKPAAVNWIEG 408
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ E+V K LKT+ + E+N KNL GSA AG+ GFNAH NIV AIF
Sbjct: 409 RGKSVVCEAVIKDEVVRKVLKTSVASLVELNMLKNLTGSAMAGALGGFNAHSSNIVSAIF 468
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
LATGQD AQ E SH IT+ E G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 469 LATGQDPAQNVESSHCITMMEPVNNGRDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 528
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG N++ A IVAG+VLAGELSL++AIAA L R+H R
Sbjct: 529 VKGASKESPGANSRLLATIVAGSVLAGELSLMSAIAAGQLVRSHMKYNR 577
>gb|AAC15475.1| (AF034760) 3-hydroxy-3-methylglutaryl coenzyme A reductase [Tagetes
erecta]
Length = 574
Score = 353 bits (896), Expect = 2e-96
Identities = 189/387 (48%), Positives = 262/387 (66%), Gaps = 8/387 (2%)
Query: 29 GDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGRNIENMIGVVQIPMGVAGPLKIN 88
GD + A IRR+ALE+ G SL + D + ++G+ E +G VQIP+G+AGPL +N
Sbjct: 178 GDCKRAASIRREALEQITGKSLSGLPLEGFDYDSILGQCCEMPVGYVQIPVGIAGPLLLN 237
Query: 89 GEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAR 148
G EF +P+ATTEG LVAS NRGC A+ +GG +L D MTRAP++R A+RA
Sbjct: 238 GT----EFSVPMATTEGCLVASTNRGCKAIYISGGATCILLKDGMTRAPVVRFGTAKRAA 293
Query: 149 EVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIA 207
E+ +++++ +N+ V K +R G+L+ V+ I G N Y RF TGDAMGMNMVT
Sbjct: 294 ELKQFLEDPMNFDTLAVVFNKSSRFGRLQSVQCAIAGKNXYNRFCCATGDAMGMNMVTKG 353
Query: 208 SEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKT 267
+ ++ ++ +FPD+ + +SGN C DKKP A+N+I GRGK+VV EAI+ E+V+K LKT
Sbjct: 354 VQNVLDFLQHDFPDMDVMGISGNYCSDKKPAAINWIEGRGKSVVCEAIIKEEVVQKVLKT 413
Query: 268 TPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEV 326
T + E+N KNL GSA AG+ GFNAH NIV A++LATGQD AQ E SH IT+ E
Sbjct: 414 TVPALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYLATGQDPAQNVESSHCITMMEA 473
Query: 327 TPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGG-DPPGVNAKKFAEIVAG 384
+G DL++S+TMPS+E+GTVGGGT++ +Q L+++GV G + PG NA+ A IVAG
Sbjct: 474 VNDGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASKEEPGSNARVLATIVAG 533
Query: 385 AVLAGELSLLAAIAAKHLARAHKMLGR 411
+VLAGELSL++AI+A L ++H R
Sbjct: 534 SVLAGELSLMSAISAGQLVKSHMKYNR 560
>sp|P34135|HMD1_DICDI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1 (HMG-COA
REDUCTASE 1) >gi|304594|gb|AAA33214.1| (L19349)
hydroxymethylglutaryl CoA reductase [Dictyostelium
discoideum]
Length = 552
Score = 353 bits (895), Expect = 3e-96
Identities = 191/415 (46%), Positives = 276/415 (66%), Gaps = 9/415 (2%)
Query: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDP 60
+K L+ E+I+ K+ GE+ +++E + GD A EIRR LE++L ++ I H D
Sbjct: 139 IKELSNEEILIKLEKGEVLAYRLENEL-GDCSRAVEIRRMLLEKQLSKKIEPIPHEGFDF 197
Query: 61 NELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTE 120
++ G+ EN+IG V IP+G AGP+++NG+ IP+ATTEG LVAS +RGC A+TE
Sbjct: 198 AKVQGQCCENVIGYVPIPVGTAGPIQLNGQLVT----IPMATTEGCLVASTHRGCKAITE 253
Query: 121 AGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVT-RHGKLRDVK 179
+GG TI MTRAP++R + +A E W+ + NY KAV T R +L +K
Sbjct: 254 SGGAKCTITSRGMTRAPVVRFSDIVKASEFVSWINDTDNYQALKAVFDSTSRFARLSAIK 313
Query: 180 PFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNA 239
I G ++Y+RF+ +TGDAMGMNMV+ E +++ ++ F D+ L++SGN+C DKKP++
Sbjct: 314 CTIAGRSVYIRFKCDTGDAMGMNMVSKGVEAVLEHLKIIFDDMTLLSISGNMCTDKKPSS 373
Query: 240 VNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGN 298
+N+ GRG++VV EA++ ++V++ LKT + + ++N KNL+GSA AGS GFNAH N
Sbjct: 374 INWTEGRGRSVVCEAMITGDVVQRVLKTNVQALVDLNIAKNLIGSAMAGSIGGFNAHASN 433
Query: 299 IVGAIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQRE 357
IV AIFLATGQD AQ E S+ IT E +G DLYI++TMPS+E+GTVGGGT +P Q
Sbjct: 434 IVTAIFLATGQDCAQNVESSNCITQMEACNDGQDLYITVTMPSIEVGTVGGGTSLPAQSA 493
Query: 358 ALSIMGVAG-GGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
L I+GV G PG NA + A+ +A AV+AGELSL++A++A HL ++H R
Sbjct: 494 CLDIIGVKGSSSSKPGANADQLAKTIASAVMAGELSLMSALSAGHLMKSHLQYNR 548
>sp|Q00583|HMD3_HEVBR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 3 (HMG-COA
REDUCTASE 3) >gi|282933|pir||S22521
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) hmg3 - Para rubber tree
>gi|168215|gb|AAA33360.1| (M74800)
3-hydroxy-3-methylglutaryl-coenzyme A reductase [Hevea
brasiliensis]
Length = 586
Score = 352 bits (894), Expect = 4e-96
Identities = 193/409 (47%), Positives = 272/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E II+ V +G I + +E + KR A IRR+ L+R G SL+ + D ++G+
Sbjct: 173 EQIIKSVVSGSIPSYSLESKLGNCKRAAL-IRRETLQRMSGRSLEGLPLDGFDYESILGQ 231
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG VQIP+G+AGPL ++G+ E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 232 CCEMAIGYVQIPVGIAGPLLLDGK----EYTVPMATTEGCLVASANRGCKAIYASGGATS 287
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R P A+RA ++ ++++ N+ V K +R +L+ V+ I G
Sbjct: 288 VLLRDGMTRAPVVRFPTAKRAADLKFFMEDPDNFDTIAVVFNKSSRFARLQSVQCAIAGK 347
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ A + ++ ++ +FPD+ + L+GN C DKK AVN+I G
Sbjct: 348 NLYMRFSCSTGDAMGMNMVSKAVQNVIDYLQNDFPDMDVIGLTGNFCADKKAAAVNWIEG 407
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ E+V+K LKT + E+N KNL GSA AGS GFNAH N+V A++
Sbjct: 408 RGKSVVCEAIIKEEVVKKVLKTNVAALVELNMIKNLTGSAVAGSLGGFNAHASNMVTAVY 467
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E +G DL+IS++MPS+E+GTVGGGT++ +Q L+++G
Sbjct: 468 IATGQDPAQNVESSHCITMMEAVNDGKDLHISVSMPSIELGTVGGGTQLASQSACLNLLG 527
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G D PG N++ A IVAG+VLAGELSL++AIAA L +H R
Sbjct: 528 VKGASKDSPGSNSRLLATIVAGSVLAGELSLMSAIAAGQLVNSHMKYNR 576
>sp|Q01559|HMDH_NICSY 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|100290|pir||S24760 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - wood tobacco
>gi|19746|emb|CAA45181.1| (X63649)
3-hydroxy-3-methylglutaryl-coenzyme A reductase
[Nicotiana sylvestris]
Length = 604
Score = 352 bits (893), Expect = 5e-96
Identities = 190/409 (46%), Positives = 274/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G++ + +E + GD + A IR++AL+R G SL+ + D ++G+
Sbjct: 191 EEIIKSVVQGKMPSYSLESKL-GDCKRAASIRKEALQRITGKSLEGLPLEGFDYESILGQ 249
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 250 CCEMPIGYVQIPVGIAGPLLLDGR----EYSVPMATTEGCLVASTNRGCKAIYASGGATS 305
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP +R A+RA E+ +V++ + + AV + +R +L+ ++ I G
Sbjct: 306 VLLRDGMTRAPCVRFGTAKRAAELKFFVEDPVKFETLAAVFNQSSRFARLQRIQCAIAGK 365
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+I G
Sbjct: 366 NLYMRFVCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVNWIEG 425
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 426 RGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVY 485
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E +G DL++S+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 486 IATGQDPAQNIESSHCITMMEAVNDGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLG 545
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 546 VKGANREVPGSNARLLATIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 594
>pir||S29623 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - radish
>gi|21104|emb|CAA48611.1| (X68652)
hydroxymethylglutaryl-CoA reductase (NADPH) [Raphanus
sativus]
Length = 573
Score = 351 bits (892), Expect = 6e-96
Identities = 190/409 (46%), Positives = 274/409 (66%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I++ V +G + + +E + GD + A IRR+AL+R G S++ + D + ++G+
Sbjct: 158 EEIVKSVLDGVVPSYSLESRL-GDCKRAASIRREALQRLTGRSIEGLPLDGFDYDSILGQ 216
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G +QIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 217 CCEMPVGYIQIPVGIAGPLLLDGY----EYSVPMATTEGCLVASTNRGCKAMYVSGGATS 272
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
T+L D MTRAP++R +ARRA E+ +++ N+ V + +R +L+ V + G
Sbjct: 273 TVLKDGMTRAPVVRFASARRASELKFFLESPENFETLAVVFNRSSRFARLQSVMCTLAGK 332
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
N Y+RF TGDAMGMNMV+ + +++ + E+FPD+ + +SGN C DKKP AVN+I G
Sbjct: 333 NAYVRFSCSTGDAMGMNMVSKGVQNVLEFLTEDFPDMDVIGISGNFCSDKKPAAVNWIEG 392
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ E V K LKT+ + E+N KNL GSA AGS GFN H NIV A+F
Sbjct: 393 RGKSVVCEAVIRGETVNKVLKTSVASLVELNMLKNLTGSAIAGSLGGFNRHASNIVSAVF 452
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
LATGQD AQ E S IT+ E +G D++IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 453 LATGQDPAQNVESSQCITMMEAINDGKDIHISVTMPSIEVGTVGGGTQLASQSACLNLLG 512
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG+N+++ A IVAGAVLAGELSL++AIAA L R+H R
Sbjct: 513 VKGASKESPGMNSRRLATIVAGAVLAGELSLMSAIAAGQLVRSHMKYNR 561
>gb|AAB62581.1| (U68072) 3-hydroxy-3-methylglutaryl CoA reductase 2 [Lycopersicon
esculentum]
Length = 601
Score = 349 bits (887), Expect = 2e-95
Identities = 190/412 (46%), Positives = 273/412 (66%), Gaps = 15/412 (3%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G+I + +E + GD + A IR++ ++R G SL+ + + ++G+
Sbjct: 188 EEIIKSVVQGKIPSYSLESKL-GDCKRAASIRKEVMQRITGKSLEGLPLEGFNYESILGQ 246
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG VQIP+G+AGPL +NG+ EF +P+ATTEG LVAS NRGC A+ +GG
Sbjct: 247 CCEMPIGYVQIPVGIAGPLLLNGK----EFSVPMATTEGCLVASTNRGCKAIYASGGATC 302
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKV----TRHGKLRDVKPFI 182
+L D MTRAP +R A+RA E+ +V++ + + + +A V +R +L+ ++ I
Sbjct: 303 ILLRDGMTRAPCVRFGTAKRAAELKFFVEDPIKF---ETLANVFNQSSRFARLQRIQCAI 359
Query: 183 VGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNF 242
G NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+
Sbjct: 360 AGKNLYMRFVCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVNW 419
Query: 243 ILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVG 301
I GRGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV
Sbjct: 420 IEGRGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVS 479
Query: 302 AIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+F+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+
Sbjct: 480 AVFIATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLN 539
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GV G + PG NA+ A +VAG+VLAGELSL++AI++ L +H R
Sbjct: 540 LLGVKGANREAPGSNARLLATVVAGSVLAGELSLMSAISSGQLVNSHMKYNR 591
>pir||S29622 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - radish
>gi|21102|emb|CAA48610.1| (X68651)
hydroxymethylglutaryl-CoA reductase (NADPH) [Raphanus
sativus]
Length = 583
Score = 349 bits (885), Expect = 4e-95
Identities = 192/410 (46%), Positives = 274/410 (66%), Gaps = 11/410 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I++ V G I + +E + KR A IRR+AL+R G S++ + D ++G+
Sbjct: 166 EEIVKSVIRGVIPSYSLESSLGECKRAAA-IRREALQRITGRSIEGLPLEGFDYESILGQ 224
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 225 CCEMPVGYVQIPVGIAGPLLLDG----CEYSVPMATTEGCLVASTNRGCKAMYVSGGGTS 280
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA--KVTRHGKLRDVKPFIVG 184
T++ D MTRAP++R +ARRA E+ ++ E+L AV + +R +L+ VK + G
Sbjct: 281 TVVKDGMTRAPVVRFASARRASELKFYL-EDLENFDTLAVVFNRSSRFARLQSVKCTLAG 339
Query: 185 NNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFIL 244
N Y+RF TGDAMGMNMV+ + +++ + ++FPD+ + +SGN C DKKP AVN+I
Sbjct: 340 KNAYVRFSCSTGDAMGMNMVSKGVQNVLEFLTDDFPDMDVIGISGNFCSDKKPAAVNWIE 399
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAI 303
GRGK+VV EA++ EIV K LKT+ + E+N KNL GSA AGS GFNAH NIV A+
Sbjct: 400 GRGKSVVCEAVIRGEIVNKVLKTSVAALVELNMLKNLTGSAVAGSLGGFNAHASNIVSAV 459
Query: 304 FLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIM 362
F+ATGQD AQ E S IT+ E +G D+++S+TMPS+E+GTVGGGT++ +Q L+++
Sbjct: 460 FIATGQDPAQNVELSQCITMMEAVNDGKDIHVSVTMPSIEVGTVGGGTQLASQSACLNLL 519
Query: 363 GVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
GV G + PG+N++ A IVAGAVLAGELSL++AIAA L ++H R
Sbjct: 520 GVKGASTESPGMNSRTLATIVAGAVLAGELSLMSAIAAGQLVKSHMKYNR 569
>sp|P43256|HMD2_ARATH 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2 (HMG-COA
REDUCTASE 2) (HMGR2) >gi|388558|gb|AAA67317.1| (L19262)
3-hydroxy-3-methylglutaryl-CoA reductase [Arabidopsis
thaliana] >gi|2262168|gb|AAB86514.1| (AC002329)
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
[Arabidopsis thaliana]
Length = 562
Score = 349 bits (885), Expect = 4e-95
Identities = 193/409 (47%), Positives = 275/409 (67%), Gaps = 11/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I++ V +G I + +E + GD + A IRR+A++R G SL + D N ++G+
Sbjct: 148 EEIVKLVIDGTIPSYSLETKL-GDCKRAAAIRREAVQRITGKSLTGLPLEGFDYNSILGQ 206
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRG A+ +GG +
Sbjct: 207 CCEMPVGYVQIPVGIAGPLLLDGV----EYSVPMATTEGCLVASTNRGFKAIHLSGGAFS 262
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
++ D MTRAP++R P+ARRA V ++++ N+ + + K +R +L+ + I G
Sbjct: 263 VLVKDAMTRAPVVRFPSARRAALVMFYLQDPSNFERLSLIFNKSSRFARLQSITCTIAGR 322
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY RF TGDAMGMNMV+ + ++ ++ EFPD+ + +SGN C DKK +AVN+I G
Sbjct: 323 NLYPRFACSTGDAMGMNMVSKGVQNVLDFVKSEFPDMDVIGISGNYCSDKKASAVNWIEG 382
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK VV EA + EIVEK LKT+ E + E+N KNLVGSA AGS GFNAH NIV A+F
Sbjct: 383 RGKHVVCEAFIKAEIVEKVLKTSVEALVELNTLKNLVGSAMAGSLGGFNAHSSNIVSAVF 442
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH +T+ + P+G DL+IS++MP +E+GTVGGGT++ +Q L+++G
Sbjct: 443 IATGQDPAQNVESSHCMTM--ILPDGDDLHISVSMPCIEVGTVGGGTQLASQAACLNLLG 500
Query: 364 VAG-GGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG NA++ A IVAG+VLAGELSL++AIAA L ++H R
Sbjct: 501 VKGSNNEKPGSNAQQLARIVAGSVLAGELSLMSAIAAGQLVKSHMKYNR 549
>sp|P48022|HMD2_LYCES 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2 (HMG-COA
REDUCTASE 2) >gi|282943|pir||S25316
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) - tomato >gi|170452|gb|AAA34169.1| (M63642)
3-hydroxy-3-methylglutaryl coenzyme A reductase
[Lycopersicon esculentum]
Length = 602
Score = 347 bits (880), Expect = 2e-94
Identities = 189/412 (45%), Positives = 273/412 (65%), Gaps = 15/412 (3%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G+I + +E + GD + A IR++ ++R G SL+ + + ++G+
Sbjct: 189 EEIIKSVVQGKIPSYSLESKL-GDCKRAASIRKEVMQRITGKSLEGLPLEGFNYESILGQ 247
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG VQIP+G+AGPL +NG+ EF +P+ATTEG LVAS NRGC A+ +GG
Sbjct: 248 CCEMPIGYVQIPVGIAGPLLLNGK----EFSVPMATTEGCLVASTNRGCKAIYASGGATC 303
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKV----TRHGKLRDVKPFI 182
+L D MTRAP +R A+RA E+ +V++ + + +++A V +R +L+ ++ I
Sbjct: 304 ILLRDGMTRAPCVRFGTAKRAAELKFFVEDPIKF---ESLANVFNQSSRFARLQRIQCAI 360
Query: 183 VGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNF 242
G NLY+R TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+
Sbjct: 361 AGKNLYMRLCCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVNW 420
Query: 243 ILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVG 301
I GRGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV
Sbjct: 421 IEGRGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVS 480
Query: 302 AIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+F+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+
Sbjct: 481 AVFIATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLN 540
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GV G + PG NA+ A +VAG+VLAGELSL++AI++ L +H R
Sbjct: 541 LLGVKGANREAPGSNARLLATVVAGSVLAGELSLMSAISSGQLVNSHMKYNR 592
>gb|AAB69726.1| (U72145) 3-hydroxy-3-methylglutaryl coenzyme a reductase
[Camptotheca acuminata]
Length = 575
Score = 347 bits (880), Expect = 2e-94
Identities = 189/409 (46%), Positives = 270/409 (65%), Gaps = 10/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E++I+ V G I + +E + GD + A IRR+AL+R G SL+ + D ++G+
Sbjct: 163 EEMIKSVVAGRIPSYSLETRL-GDCKRAAAIRREALQRLTGKSLEGLPLEGFDYETILGQ 221
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+ GPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 222 CCEMPVGYVQIPVGIVGPLLLDGR----EYSVPMATTEGCLVASTNRGCKAIYASGGATS 277
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R A+RA E+ ++++ +N+ V K +R G+L+ +K I G
Sbjct: 278 ILLRDGMTRAPVVRFSTAKRAAELKFFLEDPMNFDTLAVVFNKSSRFGRLQGIKCAIAGK 337
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNM++ + ++ ++ +FPD+ L +SGN C DKKP A N+I G
Sbjct: 338 NLYMRFTCSTGDAMGMNMISKGVQNVLDFLQNDFPDMDVLGISGNFCSDKKPAACNWIEG 397
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ E+V K LKT + E+N KNL GSA AG+ GFN+H NIV A++
Sbjct: 398 RGKSVVCEAIIKEEVVRKVLKTNVAALVELNMLKNLTGSAMAGALGGFNSHASNIVSAVY 457
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTV GGT++ +Q L ++G
Sbjct: 458 IATGQDPAQNVESSHCITMMEAVNDGKDLHISVTMPSIEVGTV-GGTQLASQAACLLLLG 516
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG N++ A IVAG+VLAGELS+++AIAA HL +H R
Sbjct: 517 VKGANKESPGSNSRLLATIVAGSVLAGELSVMSAIAAGHLVMSHMKYNR 565
>gb|AAD03789.1| (U43711) 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Morus
alba]
Length = 548
Score = 346 bits (879), Expect = 2e-94
Identities = 187/409 (45%), Positives = 272/409 (65%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II V +G I + +E + GD + IRR+AL+R G S++ + D ++G+
Sbjct: 135 EEIIRSVVDGTIPSYSLESRL-GDCKRGAAIRREALQRMTGRSIEGLPIEGFDYESILGQ 193
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++ + E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 194 CCEMPVGYVQIPVGIAGPLLLD----EFEYSVPMATTEGCLVASTNRGCKAIYMSGGATS 249
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R +A+RA E+ +V++ +N+ V + +R +L+ ++ I G
Sbjct: 250 VLLRDGMTRAPVVRFNSAKRASELKFFVEDPVNFDTLAVVFNRSSRFARLQGIQCAIAGK 309
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
N+Y+RF TGDAMGMNMV+ + + ++ +FPD+ + +SGN C DKKP AVN+I G
Sbjct: 310 NVYMRFSCSTGDAMGMNMVSKGVQNALDYLQSDFPDMDIIGISGNFCSDKKPAAVNWIEG 369
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EA++ E+V+K LKT + + E+N KNL GSA AG+ G+NAH NIV A+F
Sbjct: 370 RGKSVVCEAVIKEEVVKKVLKTNVDALVELNMLKNLAGSAVAGALGGYNAHASNIVSAVF 429
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E G DL+IS+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 430 IATGQDPAQNIESSHCITMMEAVNNGKDLHISVTMPSIEVGTVGGGTQLASQSACLNLLG 489
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + G NA+ A IVAG+VLAGELSL++AIAA L ++H R
Sbjct: 490 VKGANKESAGSNARLLATIVAGSVLAGELSLMSAIAAGQLVKSHMKYNR 538
>sp|Q41437|HMD2_SOLTU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2 (HMG-COA
REDUCTASE 2) (HMG2.2) >gi|1245484|gb|AAB52551.1|
(U51985) HMG-CoA reductase [Solanum tuberosum]
Length = 595
Score = 346 bits (878), Expect = 3e-94
Identities = 189/412 (45%), Positives = 269/412 (64%), Gaps = 15/412 (3%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II V G+ + + + GD A +R++ ++R G SL+ + ++G+
Sbjct: 186 EEIINSVVQGKFPSYSLVIQL-GDVSAAASLRKEVMQRITGKSLEGLPLEGFTYESILGQ 244
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG VQIP+G+AGPL +NG+ EF +P+ATTEG LVAS NRGC A+ +GG
Sbjct: 245 CCEMPIGYVQIPVGIAGPLLLNGK----EFSVPMATTEGCLVASTNRGCKAIYASGGATC 300
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKV----TRHGKLRDVKPFI 182
+L D MTRAP +R A+RA E+ +V++ + + + +A V +R G+L+ ++ I
Sbjct: 301 IVLRDGMTRAPCVRFGTAKRAAELKFFVEDPIKF---ETLANVFNQSSRFGRLQRIQCAI 357
Query: 183 VGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNF 242
G NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN+
Sbjct: 358 AGKNLYMRFVCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVNW 417
Query: 243 ILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVG 301
I GRGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV
Sbjct: 418 IEGRGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVS 477
Query: 302 AIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+F+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+
Sbjct: 478 AVFIATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLN 537
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GV G + PG NA+ A +VAG+VLAGELSL++AI+A L +H R
Sbjct: 538 LLGVKGANREAPGSNARLLATVVAGSVLAGELSLMSAISAGQLVNSHMKYNR 589
>sp|O64966|HMD1_GOSHI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1 (HMG-COA
REDUCTASE 1) >gi|7431200|pir||T09782
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) 1 - upland cotton >gi|2935298|gb|AAC05088.1|
(AF038045) 3-hydroxy-3-methylglutaryl-coenzyme A
reductase 1 [Gossypium hirsutum]
Length = 585
Score = 344 bits (873), Expect = 1e-93
Identities = 190/409 (46%), Positives = 268/409 (65%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II V G + +E ++ KR A IRR+AL+R G SL + D ++G+
Sbjct: 172 EEIIRSVVCGMTPSYSLESKLDDCKRAAA-IRREALQRITGKSLSGLPLDGFDYESILGQ 230
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G QIP+G+AGPL +NG E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 231 CCEMPVGYEQIPVGIAGPLLLNGR----EYSVPMATTEGCLVASTNRGCKAIHLSGGATS 286
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D MTRAP++R A+RA ++ ++++ N+ V + +R +L+ +K I G
Sbjct: 287 VLLRDGMTRAPVVRFGTAKRAADLKLYLEDPENFETLACVFNRSSRFARLQSIKCAIAGK 346
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLYLRF TGDAMGMNMV+ + ++ ++ +FPD+ + +SGN C DKKP AVN+I G
Sbjct: 347 NLYLRFSCFTGDAMGMNMVSKGVQNVLDFLQTDFPDMDVIGISGNFCSDKKPAAVNWIEG 406
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ ++V K LKT+ E + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 407 RGKSVVCEAIINGDVVTKVLKTSVESLVELNMLKNLTGSAMAGALGGFNAHASNIVTAVY 466
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E G DL++S+TMPS+E+GTVGGGT++ +Q L+++G
Sbjct: 467 IATGQDPAQNVESSHCITMMEAVNGGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLG 526
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG N+ A IVAGAVLAGELSL++A+AA L ++H R
Sbjct: 527 VKGASKESPGANSILLATIVAGAVLAGELSLMSALAAGQLVKSHMKYNR 575
>sp|Q9XEL8|HMD2_CAPAN 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2 (HMG-COA
REDUCTASE 2) >gi|4704615|gb|AAD28179.1|AF110383_1
(AF110383) 3-hydroxy-3-methylglutaryl-coenzyme A
reductase [Capsicum annuum]
Length = 604
Score = 344 bits (873), Expect = 1e-93
Identities = 189/412 (45%), Positives = 272/412 (65%), Gaps = 15/412 (3%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G+I + +E + GD + A IR++ L+R G SL+ + + ++G+
Sbjct: 191 EEIIKSVVQGKIPSYSLESKL-GDCKRAASIRKEVLQRITGKSLEGLPLDGFNYESILGQ 249
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E IG VQIP+G+AGPL +NG E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 250 CCEMTIGYVQIPVGIAGPLLLNGR----EYSVPMATTEGCLVASTNRGCKAIYASGGATS 305
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKV----TRHGKLRDVKPFI 182
+L D MTRAP +R A+RA E+ +V++ +N+ + +A V +R +L+ ++ I
Sbjct: 306 ILLRDGMTRAPCVRFGTAKRAAELKFFVEDPINF---ETLANVFNQSSRFARLQRIQCAI 362
Query: 183 VGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNF 242
G NL++RF TGDAMGMNMV+ + ++ ++ E+ D+ + +S N C DKKP AVN+
Sbjct: 363 AGKNLHMRFVCSTGDAMGMNMVSKGVQNVLDYLQNEYADMDVIGISANFCSDKKPAAVNW 422
Query: 243 ILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVG 301
I GRGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV
Sbjct: 423 IEGRGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNLTGSALAGALGGFNAHASNIVS 482
Query: 302 AIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+++ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+
Sbjct: 483 AVYIATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACLN 542
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GV G + PG NA+ A IVAG+VLAGELSL++AI+A L +H R
Sbjct: 543 LLGVKGANREAPGSNARLLATIVAGSVLAGELSLMSAISAGQLVNSHMKYNR 594
>sp|P48019|HMD1_ORYSA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|1071805|pir||S46314 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) 1 - rice
>gi|455459|gb|AAA21720.1| (L28995)
3-hydroxy-3-methylglutaryl coenzyme A reductase [Oryza
sativa]
Length = 509
Score = 342 bits (868), Expect = 4e-93
Identities = 187/409 (45%), Positives = 269/409 (65%), Gaps = 9/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+I+ VA+G + H++E + GD R A +RR+AL R G ++ + +D ++G+
Sbjct: 96 EEIVAAVASGALPSHRLESRL-GDCRRAARLRREALRRVTGRGVEGLPFDGMDYQAILGQ 154
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQ+P+GVAGPL ++G E+++P+ATTEG LVASVNR +GG +
Sbjct: 155 CCEMPVGYVQLPVGVAGPLLLDGR----EYHVPMATTEGCLVASVNRRVQGHLVSGGAFS 210
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
+L D M+RAP ++ P RA E+ + + N+ AV + +R G+L+D++ + G
Sbjct: 211 VLLRDAMSRAPAVKLPCPMRAAELKAFAEAPANFELLAAVFNRSSRFGRLQDIRCALAGR 270
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ E ++ ++ FPD+ +++SGN C DKKP AVN+I G
Sbjct: 271 NLYMRFSCITGDAMGMNMVSKGVENVLGYLQNVFPDMDVISVSGNYCSDKKPTAVNWIEG 330
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV EAI+ ++V+K LKTT E + E+N KNL GSA AG+ GFNAH NIV A+F
Sbjct: 331 RGKSVVCEAIIKGDVVQKVLKTTVEKLVELNIIKNLAGSAVAGALGGFNAHASNIVTALF 390
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E S IT+ E +G DL+IS+TMPS+E+GT+GGGT + +Q L+++G
Sbjct: 391 IATGQDPAQNVESSQCITMLEEVNDGDDLHISVTMPSIEVGTIGGGTCLASQAACLNLLG 450
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G PG NA + A IVAG+V+AG LLAA+A+ HL ++H M R
Sbjct: 451 VKGSNHGSPGANAGRLATIVAGSVVAGRALLLAALASGHLVKSHMMYNR 499
>emb|CAB97179.1| (X58371) 3-hydroxy-3-methylglutaryl coenzyme A reductase [Phycomyces
blakesleeanus]
Length = 1176
Score = 341 bits (866), Expect = 7e-93
Identities = 191/411 (46%), Positives = 262/411 (63%), Gaps = 15/411 (3%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERK-----LGISLKHIGHYSI 58
LN E++I V NG++ + +EK V GD + A IRR + R L S + +Y
Sbjct: 743 LNDEEVISLVENGKMASYALEK-VLGDLQRAVGIRRALISRASITKTLEASALPLENYHY 801
Query: 59 DPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSAL 118
D +++G EN+IG + IP+GVAGP+ I+G+ +IP+ATTEG LVAS RGC A+
Sbjct: 802 D--KVMGACCENVIGYMPIPVGVAGPMNIDGDL----IHIPMATTEGCLVASTARGCKAI 855
Query: 119 TEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDV 178
GG T ++ D MTR P + P RA W++ N + A +R +LR +
Sbjct: 856 NAGGGASTIVIADGMTRGPCVEFPTILRAAACKLWIENEGNDIVTNAFNSTSRFARLRKL 915
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
K + G +++RF TGDAMGMNM++ E+ + +I E FPD++ ++LSGN C DKKP
Sbjct: 916 KIALAGKLVFIRFSTTTGDAMGMNMISKGCEKALSIITEHFPDMQIISLSGNYCTDKKPA 975
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
A+N+I GRGK+VV EA++P IVEK LKTT + E+N KNL+GSA AGS GFNAH
Sbjct: 976 AINWIEGRGKSVVTEAVIPGAIVEKVLKTTVAALVELNISKNLIGSAMAGSVGGFNAHAA 1035
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAE-VTPEGDLYISITMPSLEIGTVGGGTRVPTQR 356
NI+ AI+LATGQD AQ E S+ IT+ + V DL+IS TMPS+E+GT+GGGT +P Q+
Sbjct: 1036 NILTAIYLATGQDPAQNVESSNCITLMKAVNDTKDLHISCTMPSIEVGTIGGGTILPPQQ 1095
Query: 357 EALSIMGVAG-GGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
L ++GV G PG NA++ A I+ AV+AGELSL AA+AA HL +AH
Sbjct: 1096 SMLDMLGVRGPHPTEPGKNAQRLARIICAAVMAGELSLCAALAAGHLVKAH 1146
>sp|P34136|HMD2_DICDI 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2 (HMG-COA
REDUCTASE 2) >gi|304596|gb|AAA33215.1| (L19350)
hydroxymethylglutaryl CoA reductase [Dictyostelium
discoideum]
Length = 481
Score = 341 bits (865), Expect = 9e-93
Identities = 196/456 (42%), Positives = 277/456 (59%), Gaps = 55/456 (12%)
Query: 2 KTLNVED-----IIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGI-------- 48
K++NVED II V GEI+ H +E + + + A IRRK L R L
Sbjct: 3 KSVNVEDLKDQEIIALVDKGEIQPHNLETRLPNNFQRAVHIRRKLLARDLQKEHQRALHA 62
Query: 49 ----------------------------------SLKHIGHYSIDPNELIGRNIENMIGV 74
SL ++ D +++G EN+IG
Sbjct: 63 QAVVAAAEKAATSGEDPSSIQPVVPPTSNLDFEGSLTNLPVDHFDYTKVLGACCENVIGY 122
Query: 75 VQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILDDKMT 134
+ IP+GVAGP+ ++G+ IP+ATTEG LVAS +RG A+T++GG T +L MT
Sbjct: 123 IPIPVGVAGPILLDGKLVS----IPMATTEGCLVASTHRGAKAITKSGGAKTVLLQSGMT 178
Query: 135 RAPLIRCPNARRAREVAEWVKENLNYLQ-EKAVAKVTRHGKLRDVKPFIVGNNLYLRFEF 193
RAP+ R P++ RA E+ +W++ N+ Q A +R +L+ +K I G +YLRF+
Sbjct: 179 RAPVCRLPSSIRAGELKQWIENQENFYQVASAFNSTSRFARLKSIKVVIAGRLVYLRFKS 238
Query: 194 ETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAE 253
TGDAMGMNMV+ E+ ++VI E FP++ L+LSGN+C DKKP+++N++ GRGK+VVAE
Sbjct: 239 STGDAMGMNMVSKGVEKALEVITEYFPEMEVLSLSGNVCTDKKPSSINWLEGRGKSVVAE 298
Query: 254 AIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEA 312
A++ +IV LKTT E + +N KNL+GSA AGS GFNAH NIV A+++ATGQD A
Sbjct: 299 AVISGDIVRDVLKTTVEALVSLNIDKNLIGSAMAGSIGGFNAHASNIVTALYIATGQDPA 358
Query: 313 QITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGG-DP 370
Q E S+ IT+ E G DLYIS+TMPS+E+GTVGGGT +P Q L ++ + G +
Sbjct: 359 QNVESSNCITLMESINGGKDLYISVTMPSIEVGTVGGGTHLPAQSACLDLLKIRGANLER 418
Query: 371 PGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
PG N+++ A +VA AVL+GELSL++A+AA HL R+H
Sbjct: 419 PGANSEQLARVVAAAVLSGELSLMSALAAGHLVRSH 454
>sp|Q29512|HMDH_RABIT 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
Length = 888
Score = 339 bits (859), Expect = 5e-92
Identities = 190/417 (45%), Positives = 272/417 (64%), Gaps = 12/417 (2%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSID 59
K L+ +II+ V I +++E + +R IRR+ L +KL SL+++ + +
Sbjct: 460 KFLSDAEIIQLVNAKHIPAYKLETLMETHER-GVSIRRQLLSKKLPEPSSLQYLPYRDYN 518
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
+ ++G EN+IG + IP+GV GPL ++G+ EF +P+ATTEG LVAS NRGC A+
Sbjct: 519 YSLVLGACCENVIGYMPIPVGVVGPLCLDGK----EFQVPMATTEGCLVASTNRGCRAIC 574
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRHGKLRDV 178
GG + +L D MTR P++R P A + EV W++ + + ++A +R +L+ +
Sbjct: 575 LGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKL 634
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
+ G NLY+RF+ TGDAMGMNM++ +E+ + + E FP+++ LA+SGN C DKKP
Sbjct: 635 HISMAGRNLYIRFQSRTGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPA 694
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
AVN+I GRGKTVV EA++P ++V + LKTT E + +VN KNLVGSA AGS G+NAH
Sbjct: 695 AVNWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAA 754
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQ 355
N V AI++A GQD AQ S+ IT+ E + P DLYIS TMPS+EIGTVGGGT + Q
Sbjct: 755 NYVTAIYIACGQDAAQNVGSSNCITLMEASGPPNEDLYISCTMPSIEIGTVGGGTNLLPQ 814
Query: 356 REALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+ L ++GV G D PG NA++ A IV G V+AGELSL+AA+AA HL ++H + R
Sbjct: 815 QACLQMLGVQGACKDSPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNR 871
>pdb|1DQ8|A Chain A, Complex Of The Catalytic Portion Of Human Hmg-Coa
Reductase With Hmg And Coa >gi|7245360|pdb|1DQ9|D Chain
D, Complex Of Catalytic Portion Of Human Hmg-Coa
Reductase With Hmg-Coa >gi|7245361|pdb|1DQA|A Chain A,
Complex Of The Catalytic Portion Of Human Hmg-Coa
Reductase With Hmg, Coa, And Nadp+
>gi|7245356|pdb|1DQ8|D Chain D, Complex Of The Catalytic
Portion Of Human Hmg-Coa Reductase With Hmg And Coa
>gi|7245359|pdb|1DQ9|C Chain C, Complex Of Catalytic
Portion Of Human Hmg-Coa Reductase With Hmg-Coa
>gi|7245362|pdb|1DQA|B Chain B, Complex Of The Catalytic
Portion Of Human Hmg-Coa Reductase With Hmg, Coa, And
Nadp+ >gi|7245354|pdb|1DQ8|B Chain B, Complex Of The
Catalytic Portion Of Human Hmg-Coa Reductase With Hmg
And Coa >gi|7245357|pdb|1DQ9|A Chain A, Complex Of
Catalytic Portion Of Human Hmg-Coa Reductase With
Hmg-Coa >gi|7245358|pdb|1DQ9|B Chain B, Complex Of
Catalytic Portion Of Human Hmg-Coa Reductase With
Hmg-Coa >gi|7245363|pdb|1DQA|C Chain C, Complex Of The
Catalytic Portion Of Human Hmg-Coa Reductase With Hmg,
Coa, And Nadp+ >gi|7245355|pdb|1DQ8|C Chain C, Complex
Of The Catalytic Portion Of Human Hmg-Coa Reductase With
Hmg And Coa >gi|7245364|pdb|1DQA|D Chain D, Complex Of
The Catalytic Portion Of Human Hmg-Coa Reductase With
Hmg, Coa, And Nadp+
Length = 467
Score = 337 bits (855), Expect = 1e-91
Identities = 189/417 (45%), Positives = 273/417 (65%), Gaps = 12/417 (2%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSID 59
K L+ +II+ V I +++E + +R IRR+ L +KL SL+++ + +
Sbjct: 39 KFLSDAEIIQLVNAKHIPAYKLETLIETHER-GVSIRRQLLSKKLSEPSSLQYLPYRDYN 97
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
+ ++G EN+IG + IP+GVAGPL ++ + EF +P+ATTEG LVAS NRGC A+
Sbjct: 98 YSLVMGACCENVIGYMPIPVGVAGPLCLDEK----EFQVPMATTEGCLVASTNRGCRAIG 153
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRHGKLRDV 178
GG + +L D MTR P++R P A + EV W++ + + + ++A +R +L+ +
Sbjct: 154 LGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL 213
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
I G NLY+RF+ +GDAMGMNM++ +E+ + + E FP+++ LA+SGN C DKKP
Sbjct: 214 HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPA 273
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
A+N+I GRGK+VV EA++P ++V + LKTT E + EVN KNLVGSA AGS G+NAH
Sbjct: 274 AINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAA 333
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQ 355
NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVGGGT + Q
Sbjct: 334 NIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQ 393
Query: 356 REALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+ L ++GV G D PG NA++ A IV G V+AGELSL+AA+AA HL ++H + R
Sbjct: 394 QACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNR 450
>gb|AAD20975.2| (AF071750) 3-hydroxy-3-methylglutaryl coenzyme A reductase [Ips
paraconfusus]
Length = 866
Score = 337 bits (855), Expect = 1e-91
Identities = 199/409 (48%), Positives = 268/409 (64%), Gaps = 13/409 (3%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGIS--LKHIGHYSIDPN 61
L E+II + N I +Q+EK V+ +R IRRK L R L L+ + + + D +
Sbjct: 436 LTDEEIILLIKNRHIAGYQIEKAVDNPER-GVGIRRKILGRDLDAPKVLEGLPYRNYDYS 494
Query: 62 ELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEA 121
++G EN+IG + IP+G AGPL ++G+ E Y+P+ATTEG LVAS NRGC AL EA
Sbjct: 495 LVMGACCENVIGYMPIPVGYAGPLVLDGK----EIYVPMATTEGCLVASTNRGCRALKEA 550
Query: 122 GGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPF 181
G V + I+ D MTR P++R P+ RA + +W+++N + ++E+ + +R +L+ V
Sbjct: 551 G-VTSRIVADGMTRGPVVRFPSIIRASQAMQWIQDNFDGIKEQFDSS-SRFARLQRVTMK 608
Query: 182 IVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVN 241
I G L++RF TGDAMGMNM++ +E +K ++ F D+ L+LSGN C DKKP AVN
Sbjct: 609 IAGRLLFIRFVATTGDAMGMNMLSKGTEYSLKFVQRAFEDMEILSLSGNFCTDKKPAAVN 668
Query: 242 FILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIV 300
+I GRGK+VV EAIVP +IV LKT + +VN KN+VGSA AGS GFNAH NIV
Sbjct: 669 WIEGRGKSVVCEAIVPAKIVANILKTNVHALVDVNNSKNMVGSAVAGSIGGFNAHAANIV 728
Query: 301 GAIFLATGQDEAQITEGSHGITIAEV-TPEG-DLYISITMPSLEIGTVGGGTRVPTQREA 358
AIFLATGQD AQ S+ +T+ E P G DLYIS TMPS+EIGT+GGGT +P Q
Sbjct: 729 TAIFLATGQDPAQNVGSSNCMTLMEPWGPTGEDLYISCTMPSIEIGTIGGGTILPPQGTC 788
Query: 359 LSIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
L ++GV G PG NA + A+IV VLAGELSL++A+AA HL R+H
Sbjct: 789 LEMLGVRGSNIAEPGANASQLAKIVGATVLAGELSLMSALAAGHLVRSH 837
>sp|P00347|HMDH_CRIGR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|65935|pir||RDHYE hydroxymethylglutaryl-CoA reductase
(NADPH) (EC 1.1.1.34) - Chinese hamster
>gi|49648|emb|CAA25189.1| (X00494) HMG CoA reductase
[Mesocricetus auratus] >gi|387052|gb|AAA36989.1|
(L00183) 3-hydroxy-3-methylglutaryl coenzyme A
[Mesocricetus auratus] >gi|223946|prf||1005248A
reductase,HMG CoA [Cricetinae gen. sp.]
Length = 887
Score = 336 bits (853), Expect = 2e-91
Identities = 191/417 (45%), Positives = 272/417 (64%), Gaps = 12/417 (2%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSID 59
K L+ +II+ V I +++E + +R IRR+ L KL SL+++ + +
Sbjct: 459 KFLSDAEIIQLVNAKHIPAYKLETLMETHER-GVSIRRQLLSTKLPEPSSLQYLPYRDYN 517
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
+ ++G EN+IG + IP+GVAGPL ++G+ E+ +P+ATTEG LVAS NRGC A+
Sbjct: 518 YSLVMGACCENVIGYMPIPVGVAGPLCLDGK----EYQVPMATTEGCLVASTNRGCRAIG 573
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEK-AVAKVTRHGKLRDV 178
GG + +L D MTR P++R P A + EV W++ + K A +R +L+ +
Sbjct: 574 LGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKDAFDSTSRFARLQKL 633
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
+ G NLY+RF+ +TGDAMGMNM++ +E+ + ++E FP+++ LA+SGN C DKKP
Sbjct: 634 HVTMAGRNLYIRFQSKTGDAMGMNMISKGTEKALLKLQEFFPEMQILAVSGNYCTDKKPA 693
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
A+N+I GRGKTVV EA++P ++V + LKTT E + +VN KNLVGSA AGS G+NAH
Sbjct: 694 AINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAA 753
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQ 355
NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVGGGT + Q
Sbjct: 754 NIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQ 813
Query: 356 REALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+ L ++GV G D PG NA++ A IV G V+AGELSL+AA+AA HL R+H + R
Sbjct: 814 QACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNR 870
>gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Homo sapiens]
>gi|123343|sp|P04035|HMDH_HUMAN
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA
REDUCTASE) >gi|65934|pir||RDHUE
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) - human >gi|306865|gb|AAA52679.1| (M11058)
3-hydroxy-3-methylglutaryl coenzyme A reductase [Homo
sapiens] >gi|10644584|gb|AAG21343.1| (AF273765)
3-hydroxy-3-methylglutaryl-coenzyme A reductase [Homo
sapiens]
Length = 888
Score = 336 bits (853), Expect = 2e-91
Identities = 189/417 (45%), Positives = 273/417 (65%), Gaps = 12/417 (2%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSID 59
K L+ +II+ V I +++E + +R IRR+ L +KL SL+++ + +
Sbjct: 460 KFLSDAEIIQLVNAKHIPAYKLETLMETHER-GVSIRRQLLSKKLSEPSSLQYLPYRDYN 518
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
+ ++G EN+IG + IP+GVAGPL ++ + EF +P+ATTEG LVAS NRGC A+
Sbjct: 519 YSLVMGACCENVIGYMPIPVGVAGPLCLDEK----EFQVPMATTEGCLVASTNRGCRAIG 574
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRHGKLRDV 178
GG + +L D MTR P++R P A + EV W++ + + + ++A +R +L+ +
Sbjct: 575 LGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKL 634
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
I G NLY+RF+ +GDAMGMNM++ +E+ + + E FP+++ LA+SGN C DKKP
Sbjct: 635 HTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPA 694
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
A+N+I GRGK+VV EA++P ++V + LKTT E + EVN KNLVGSA AGS G+NAH
Sbjct: 695 AINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAA 754
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQ 355
NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVGGGT + Q
Sbjct: 755 NIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQ 814
Query: 356 REALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+ L ++GV G D PG NA++ A IV G V+AGELSL+AA+AA HL ++H + R
Sbjct: 815 QACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNR 871
>pir||A23586 hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) - golden hamster
Length = 887
Score = 336 bits (853), Expect = 2e-91
Identities = 192/417 (46%), Positives = 271/417 (64%), Gaps = 12/417 (2%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSID 59
K L+ +II+ V I +++E + +R IRR+ L KL SL+++ + +
Sbjct: 459 KFLSDAEIIQLVNAKHIPAYKLETLMETHER-GVSIRRQLLSTKLPEPSSLQYLPYRDYN 517
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
+ ++G EN+IG + IP+GVAGPL ++G+ E+ +P+ATTEG LVAS NRGC A+
Sbjct: 518 YSLVMGACCENVIGYMPIPVGVAGPLCLDGK----EYQVPMATTEGCLVASTNRGCRAIG 573
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEK-AVAKVTRHGKLRDV 178
GG + +L D MTR P++R P A + EV W++ + K A +R +L+ +
Sbjct: 574 LGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKDAFDSTSRFARLQKL 633
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
+ G NLY+RF+ +TGDAMGMNM++ +E+ + ++E FP+++ LA+SGN C DKKP
Sbjct: 634 HVTMAGRNLYIRFQSKTGDAMGMNMISKGTEKALVKLQEFFPEMQILAVSGNYCTDKKPA 693
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
AVN+I GRGKTVV EA++P +V + LKTT E + +VN KNLVGSA AGS G+NAH
Sbjct: 694 AVNWIEGRGKTVVCEAVIPARVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAA 753
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQ 355
NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVGGGT + Q
Sbjct: 754 NIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQ 813
Query: 356 REALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+ L ++GV G D PG NA++ A IV G V+AGELSL+AA+AA HL R+H + R
Sbjct: 814 QACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNR 870
>sp|P09610|HMDH_MESAU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|305355|gb|AAA37077.1| (M12705)
3-hydroxy-3-methylglutaral coenzyme A reductase (EC
1.1.1.34) [Mesocricetus auratus]
Length = 887
Score = 336 bits (853), Expect = 2e-91
Identities = 192/417 (46%), Positives = 271/417 (64%), Gaps = 12/417 (2%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSID 59
K L+ +II+ V I +++E + +R IRR+ L KL SL+++ + +
Sbjct: 459 KFLSDAEIIQLVNAKHIPAYKLETLMETHER-GVSIRRQLLSTKLPEPSSLQYLPYRDYN 517
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
+ ++G EN+IG + IP+GVAGPL ++G+ E+ +P+ATTEG LVAS NRGC A+
Sbjct: 518 YSLVMGACCENVIGYMPIPVGVAGPLCLDGK----EYQVPMATTEGCLVASTNRGCRAIG 573
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEK-AVAKVTRHGKLRDV 178
GG + +L D MTR P++R P A + EV W++ + K A +R +L+ +
Sbjct: 574 LGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKDAFDSTSRFARLQKL 633
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
+ G NLY+RF+ +TGDAMGMNM++ +E+ + ++E FP+++ LA+SGN C DKKP
Sbjct: 634 HVTMAGRNLYIRFQSKTGDAMGMNMISKGTEKALVKLQEFFPEMQILAVSGNYCTDKKPA 693
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
AVN+I GRGKTVV EA++P +V + LKTT E + +VN KNLVGSA AGS G+NAH
Sbjct: 694 AVNWIEGRGKTVVCEAVIPARVVREVLKTTTEAMIDVNINKNLVGSAMAGSIGGYNAHAA 753
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQ 355
NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVGGGT + Q
Sbjct: 754 NIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQ 813
Query: 356 REALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+ L ++GV G D PG NA++ A IV G V+AGELSL+AA+AA HL R+H + R
Sbjct: 814 QACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNR 870
>gi|6981028 3 [Rattus norvegicus] >gi|1708252|sp|P51639|HMDH_RAT
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA
REDUCTASE) >gi|516635|gb|AAA40608.1| (M29249)
3-hydroxy-3-methylglutaryl coenzyme A reductase [Rattus
norvegicus]
Length = 887
Score = 332 bits (842), Expect = 5e-90
Identities = 186/417 (44%), Positives = 272/417 (64%), Gaps = 12/417 (2%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSID 59
K L+ +II+ V I +++E + +R IRR+ L KL SL+++ + +
Sbjct: 459 KFLSDAEIIQLVNAKHIPAYKLETLMETHER-GVSIRRQLLSAKLAEPSSLQYLPYRDYN 517
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
+ ++G EN+IG + IP+GVAGPL ++G+ E+ +P+ATTEG LVAS NRGC A++
Sbjct: 518 YSLVMGACCENVIGYMPIPVGVAGPLCLDGK----EYQVPMATTEGCLVASTNRGCRAIS 573
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRHGKLRDV 178
GG + +L D M+R P++R P A + EV W++ + + ++A +R +L+ +
Sbjct: 574 LGGGASSRVLADGMSRGPVVRLPRACDSAEVKSWLETPEGFAVVKEAFDSTSRFARLQKL 633
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
+ G NLY+R + +TGDAMGMNM++ +E+ + ++E P+++ LA+SGN C DKKP
Sbjct: 634 HVTLAGRNLYIRLQSKTGDAMGMNMISKGTEKALLKLQEGVPELQILAVSGNYCTDKKPA 693
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
A+N+I GRGKTVV EA++P ++V + LKTT E + +VN KNLVGSA AGS G+N H
Sbjct: 694 AINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSAMAGSIGGYNLHAA 753
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQ 355
NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVGGGT + Q
Sbjct: 754 NIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQ 813
Query: 356 REALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+ L ++GV G D PG NA++ A IV G V+AGELSL+AA+AA HL R+H + R
Sbjct: 814 QACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNR 870
>gb|AAB62280.1| (L78791) hydroxymethylglutaryl CoA reductase [Trypanosoma cruzi]
Length = 435
Score = 332 bits (842), Expect = 5e-90
Identities = 186/414 (44%), Positives = 261/414 (62%), Gaps = 17/414 (4%)
Query: 9 IIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALE---------RKLGISLKHIGHYSID 59
+++ V + +I + +E+ + D R A E+RR+ + +K +L I + D
Sbjct: 25 LVDAVKSRKISFYGLEQALEPDYRRAIEVRREVVSEIASQQPEAKKKQSALHTIPFENYD 84
Query: 60 PNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALT 119
N+++G+N EN+IG V IP+GVAGP+ I+G+ E+ IP+ATTEGALVAS +RG A+T
Sbjct: 85 WNKVVGQNCENIIGYVPIPLGVAGPILIDGK----EYPIPMATTEGALVASTHRGARAIT 140
Query: 120 EAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVK 179
+GG T +L + MTRAP++ P+ A + ++ EN L+E A T++GKL +K
Sbjct: 141 RSGGCKTLLLGEGMTRAPVVELPSLEEAGRLHKYCNENFLSLKE-AFESTTQYGKLNSLK 199
Query: 180 PFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNA 239
+ G YLRF TGDAMGMNM+T ++ + V+++ FP + LALSGN C DKKP+A
Sbjct: 200 CVLAGRKAYLRFRATTGDAMGMNMITKGVDKALSVLQQHFPSMEILALSGNYCTDKKPSA 259
Query: 240 VNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGN 298
VN+I GRGK+VVAEA + ++VE LK T + + +N KNLVGSA AGS GFNA N
Sbjct: 260 VNWIDGRGKSVVAEATLLADVVEDTLKCTVDSLVSLNIDKNLVGSAMAGSVGGFNAQAAN 319
Query: 299 IVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREA 358
V AIF+ATGQD AQ+ E S IT DL IS+TMPS+E+G VGGGT + QR
Sbjct: 320 AVAAIFIATGQDPAQVVESSMCITTMSKV-GNDLLISVTMPSIEVGVVGGGTGLAAQRGC 378
Query: 359 LSIMGVAG-GGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
L ++G G + PG NA+ + +VA VL+ ELSL++ +AA HL AH L R
Sbjct: 379 LELIGCGGPSKESPGTNAQLLSRVVAAGVLSAELSLMSGLAAGHLLSAHMRLNR 432
>gb|AAD38406.1|AF155593_1 (AF155593) 3-hydroxy-3-methylglutaryl coenzyme A reductase
[Leishmania major]
Length = 434
Score = 332 bits (841), Expect = 6e-90
Identities = 180/412 (43%), Positives = 271/412 (65%), Gaps = 14/412 (3%)
Query: 8 DIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGIS------LKHIGHYSIDPN 61
+I+++V N +I H +E+ + D A IRR+ +++K+ S L+ + + + D +
Sbjct: 24 EIMKQVENKKIAFHGLEQALAPDYDRAIAIRREIVKKKICPSPAATHPLERVPYKNYDWS 83
Query: 62 ELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEA 121
++G++ EN++G V +P+G+AGPL ++G+ E +P+ATTEGALVAS +RG A+ +
Sbjct: 84 SVVGQSCENILGYVPVPVGLAGPLLLDGK----EVALPMATTEGALVASAHRGARAINLS 139
Query: 122 GGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPF 181
GG T +L + MTRAP++ + A V ++ +E + L+E A TR GKL +K
Sbjct: 140 GGCRTAVLKEGMTRAPVVEVNSFDEAITVIKFCEERFDVLRE-AFESTTRFGKLLSIKCA 198
Query: 182 IVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVN 241
+ G ++LRF TGDAMGMNM+T ++ ++V+++ P VR L LSGN C DKKP+A+N
Sbjct: 199 MAGRQVHLRFSAFTGDAMGMNMITKGCDKALQVLQQHIPSVRVLTLSGNFCTDKKPSALN 258
Query: 242 FILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIV 300
++ GRGK+VVAEA++ R++VE LK T + + +N KNL GSA AGS GFNAH NIV
Sbjct: 259 WVEGRGKSVVAEAVIKRDVVESVLKCTVDSVVSLNVTKNLRGSALAGSIGGFNAHAANIV 318
Query: 301 GAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+++ATGQD AQ+ E + +T + E DL IS+ MPS+E+G VGGGT + +QR L
Sbjct: 319 AALYIATGQDPAQVVESATCMTTVDKAGE-DLVISLMMPSIEVGAVGGGTGLSSQRAMLE 377
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+MG AG + PG ++++ A +VAGAV+ GELSLL+ +AA HL AH L R
Sbjct: 378 LMGCAGSNKEDPGAHSRQIARVVAGAVICGELSLLSGLAAGHLLSAHMKLNR 429
>gb|AAA33358.1| (M74798) 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Hevea
brasiliensis]
Length = 373
Score = 330 bits (838), Expect = 1e-89
Identities = 177/367 (48%), Positives = 249/367 (67%), Gaps = 8/367 (2%)
Query: 49 SLKHIGHYSIDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALV 108
SL+ + D ++G+ E IG VQIP+G+AGPL ++G+ E+ +P+ATTEG LV
Sbjct: 1 SLEGLPLDGFDYESILGQCCEMAIGYVQIPVGIAGPLLLDGK----EYTVPMATTEGCLV 56
Query: 109 ASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA- 167
AS NRGC A+ +GG + +L D MTRAP++R P A+RA ++ ++++ N+ V
Sbjct: 57 ASANRGCKAIYASGGATSVLLRDGMTRAPVVRFPTAKRAADLKFFMEDPDNFDTIAVVFN 116
Query: 168 KVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLAL 227
K +R +L+ V+ I G NLY+RF TGDAMGMNMV+ A + ++ ++ +FPD+ + L
Sbjct: 117 KSSRFARLQSVQCAIAGKNLYMRFSCSTGDAMGMNMVSKAVQNVIDYLQNDFPDMDVIGL 176
Query: 228 SGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQA 287
+GN C DKK AVN+I GRGK+VV EAI+ E+V+K LKT + E+N KNL GSA A
Sbjct: 177 TGNFCADKKAAAVNWIEGRGKSVVCEAIIKEEVVKKVLKTNVAALVELNMIKNLTGSAVA 236
Query: 288 GSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGT 345
GS GFNAH N+V A+++ATGQD AQ E SH IT+ E +G DL+IS++MPS+E+GT
Sbjct: 237 GSLGGFNAHASNMVTAVYIATGQDPAQNVESSHCITMMEAVNDGKDLHISVSMPSIELGT 296
Query: 346 VGGGTRVPTQREALSIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLAR 404
VGGGT++ +Q L+++GV G D PG N++ A IVAG+VLAGELSL++AIAA L
Sbjct: 297 VGGGTQLASQSACLNLLGVKGASKDSPGSNSRLLATIVAGSVLAGELSLMSAIAAGQLVN 356
Query: 405 AHKMLGR 411
+H R
Sbjct: 357 SHMKYNR 363
>sp|P20715|HMDH_XENLA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|104076|pir||A35728 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - African clawed frog
>gi|214237|gb|AAA49740.1| (M29258)
3-hydroxy-3-methylglutaryl-coenzyme A reductase [Xenopus
laevis]
Length = 883
Score = 328 bits (833), Expect = 5e-89
Identities = 185/411 (45%), Positives = 263/411 (63%), Gaps = 12/411 (2%)
Query: 8 DIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSIDPNELIG 65
++I V I +++E + + IRR+ L KL +L+ + + + + + ++G
Sbjct: 461 EVISLVNAKHIPAYKLETMMESPRE-GVAIRRQMLSDKLPQRSALQSLPYKNYNYSLVMG 519
Query: 66 RNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVV 125
EN+IG + IP+GVAGPL +N + E+ +P+ATTEG LVAS NRGC A+ GG
Sbjct: 520 ACCENVIGYMPIPVGVAGPLLLNNK----EYQVPMATTEGCLVASTNRGCRAIMLGGGAK 575
Query: 126 TTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEK-AVAKVTRHGKLRDVKPFIVG 184
+ +L D MTR P++R P A A EV W+ + K A +R +L ++ + G
Sbjct: 576 SRVLADGMTRGPVVRLPTACDAAEVKAWLDSAEGFKVIKDAFDSTSRFARLGRLQNCVAG 635
Query: 185 NNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFIL 244
NLY+RF+ +TGDAMGMNM++ +E+ + ++EEFPD+ LA+SGN C DKKP A+N+I
Sbjct: 636 RNLYIRFQSKTGDAMGMNMISKVTEQALARLQEEFPDLHVLAVSGNYCTDKKPAAINWIE 695
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAI 303
GRGK+VV EAI+P ++V + LK++ E + EVN KN +GSA AGS G+NAH NIV AI
Sbjct: 696 GRGKSVVCEAIIPAKVVREVLKSSTEALVEVNINKNFIGSAMAGSIGGYNAHAANIVTAI 755
Query: 304 FLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGGGTRVPTQREALSI 361
++A GQD AQ S+ ITI E T DLYIS TMPS+EIGTVGGGT + Q+ L +
Sbjct: 756 YIACGQDAAQNVGSSNCITIMEATGPTYEDLYISCTMPSIEIGTVGGGTNLAPQQACLQM 815
Query: 362 MGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+GV G + PG NA + A+IV V+AGELSL+AA+AA HL ++H + R
Sbjct: 816 LGVQGASTETPGKNACQLAQIVCSTVMAGELSLMAALAAGHLVKSHMVHNR 866
>gb|AAB69727.1| (U72146) 3-hydroxy-3-methylglutaryl coenzyme A reductase
[Camptotheca acuminata]
Length = 589
Score = 328 bits (832), Expect = 7e-89
Identities = 181/409 (44%), Positives = 263/409 (64%), Gaps = 10/409 (2%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G + +E + KR A IRR+AL+R G SL + D ++G+
Sbjct: 177 EEIIKSVVAGTTPSYSLESRLGNCKRAAA-IRREALQRLTGKSLAGLPLDGFDYESILGQ 235
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQ+ +G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 236 CCEMAVGYVQMAVGIAGPLLLDGR----EYLVPMATTEGCLVASTNRGCKAIYASGGATS 291
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGN 185
IL D MTRAP++R A+ + E+ ++++ N+ V K +R G+ + + + G
Sbjct: 292 VILRDGMTRAPVVRFGTAKMSAELKFFLEDPRNFDTLAVVFNKSSRFGRFQGIHCALAGQ 351
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILG 245
NLY+RF TGDAMGMNMV+ + ++ ++ +F D+ + +SGN C DKKP AVN+I G
Sbjct: 352 NLYMRFSCSTGDAMGMNMVSKGVQNVLDFLQNDFSDMDVIGISGNFCSDKKPAAVNWIEG 411
Query: 246 RGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIF 304
RGK+VV E+I+ E+V K LKT + E+N KNL GSA AG+ GFNAH NIV A++
Sbjct: 412 RGKSVVCESIIKEEVVRKVLKTNVASLVELNMLKNLTGSAMAGALGGFNAHASNIVSAVY 471
Query: 305 LATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIMG 363
+ATGQD AQ E SH IT+ E +G DL++S++MPS+E+ VGGGT++ +Q L+++G
Sbjct: 472 IATGQDPAQNVESSHCITMMEAVNDGKDLHVSVSMPSIEV-IVGGGTQLASQSACLNLLG 530
Query: 364 VAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
V G + PG N++ A IVAG+VLAGELSL++AIAA L ++H R
Sbjct: 531 VKGASKESPGSNSRLLATIVAGSVLAGELSLMSAIAAGQLVKSHMKYNR 579
>pir||S30338 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - German
cockroach
Length = 856
Score = 326 bits (827), Expect = 3e-88
Identities = 185/406 (45%), Positives = 262/406 (63%), Gaps = 13/406 (3%)
Query: 8 DIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGI--SLKHIGHYSIDPNELIG 65
+++ V +G I +Q+EK V +R IRR+ L + + +L ++ + + D +++G
Sbjct: 435 EVMALVTSGHIAGYQLEKVVRNPER-GVGIRRQILTKTADLKDALDNLPYKNYDYLKVMG 493
Query: 66 RNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVV 125
EN+IG + +P+GVAGPL ++G ++PLATTEG LVAS NRG AL G V
Sbjct: 494 ACCENVIGYMPVPVGVAGPLNLDGRLV----HVPLATTEGCLVASTNRGMRALMRCG-VT 548
Query: 126 TTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQ-EKAVAKVTRHGKLRDVKPFIVG 184
+ I+ D MTR P++R PN RA E W++ N+ Q +K +R +L + + G
Sbjct: 549 SRIVADGMTRGPVVRFPNIDRASEAMLWMQVPYNFEQIKKNFDSTSRFARLSKIHIRVAG 608
Query: 185 NNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFIL 244
+L++RF TGDAMGMNM++ +E + +++ +PD+ L+LSGN C DKKP AVN+I
Sbjct: 609 RHLFIRFIATTGDAMGMNMLSKGTEVALAYVQQVYPDMEILSLSGNFCTDKKPAAVNWIE 668
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAI 303
GRGK+VV EAIVP +I++ LKT+ + + +VN KNL+GSA AGS GFNAH NIV AI
Sbjct: 669 GRGKSVVCEAIVPADIIKSVLKTSVQALVDVNITKNLIGSAVAGSIGGFNAHAANIVTAI 728
Query: 304 FLATGQDEAQITEGSHGITIAEVTPEG--DLYISITMPSLEIGTVGGGTRVPTQREALSI 361
F+ATGQD AQ S+ +T+ E E DLY+S TMPS+EIGT+GGGT +P Q L +
Sbjct: 729 FIATGQDPAQNVGSSNCMTLMEPWGEDGKDLYVSCTMPSIEIGTIGGGTVLPPQAACLDM 788
Query: 362 MGVAGGGD-PPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
+GV G + PG NA A IV G VLAGELSL++A+AA HL ++H
Sbjct: 789 LGVRGANEICPGENANTLARIVCGTVLAGELSLMSALAAGHLVKSH 834
>sp|P54960|HMDH_BLAGE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|1655537|emb|CAA49628.1| (X70034)
hydroxymethylglutaryl-CoA reductase (NADPH) [Blattella
germanica]
Length = 856
Score = 326 bits (827), Expect = 3e-88
Identities = 185/406 (45%), Positives = 262/406 (63%), Gaps = 13/406 (3%)
Query: 8 DIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGI--SLKHIGHYSIDPNELIG 65
+++ V +G I +Q+EK V +R IRR+ L + + +L ++ + + D +++G
Sbjct: 435 EVMALVTSGHIAGYQLEKVVRNPER-GVGIRRQILTKTADLKDALDNLPYKNYDYLKVMG 493
Query: 66 RNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVV 125
EN+IG + +P+GVAGPL ++G ++PLATTEG LVAS NRG AL G V
Sbjct: 494 ACCENVIGYMPVPVGVAGPLNLDGRLV----HVPLATTEGCLVASTNRGMRALMRCG-VT 548
Query: 126 TTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQ-EKAVAKVTRHGKLRDVKPFIVG 184
+ I+ D MTR P++R PN RA E W++ N+ Q +K +R +L + + G
Sbjct: 549 SRIVADGMTRGPVVRFPNIDRASEAMLWMQVPYNFEQIKKNFDSTSRFARLSKIHIRVAG 608
Query: 185 NNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFIL 244
+L++RF TGDAMGMNM++ +E + +++ +PD+ L+LSGN C DKKP AVN+I
Sbjct: 609 RHLFIRFIATTGDAMGMNMLSKGTEVALAYVQQVYPDMEILSLSGNFCTDKKPAAVNWIE 668
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAI 303
GRGK+VV EAIVP +I++ LKT+ + + +VN KNL+GSA AGS GFNAH NIV AI
Sbjct: 669 GRGKSVVCEAIVPADIIKSVLKTSVQALMDVNITKNLIGSAVAGSIGGFNAHAANIVTAI 728
Query: 304 FLATGQDEAQITEGSHGITIAEVTPEG--DLYISITMPSLEIGTVGGGTRVPTQREALSI 361
F+ATGQD AQ S+ +T+ E E DLY+S TMPS+EIGT+GGGT +P Q L +
Sbjct: 729 FIATGQDPAQNVGSSNCMTLMEPWGEDGKDLYVSCTMPSIEIGTIGGGTVLPPQAACLDM 788
Query: 362 MGVAGGGDP-PGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
+GV G + PG NA A IV G VLAGELSL++A+AA HL ++H
Sbjct: 789 LGVRGANEMCPGENANTLARIVCGTVLAGELSLMSALAAGHLVKSH 834
>gb|AAF80373.1| (AF159138) HMG-CoA reductase [Dendroctonus jeffreyi]
>gi|8886086|gb|AAF80374.1|AF159136_1 (AF159136) HMG-CoA
reductase [Dendroctonus jeffreyi]
Length = 846
Score = 324 bits (823), Expect = 8e-88
Identities = 191/411 (46%), Positives = 266/411 (64%), Gaps = 14/411 (3%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGIS---LKHIGHYSIDP 60
L ++II + N I +Q+EK V+ +R IRRK L R L S L+++ + D
Sbjct: 416 LTDDEIILLIKNKNIAAYQIEKEVDDPER-GVGIRRKILGRDLLESPKLLENLPFRNYDY 474
Query: 61 NELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTE 120
+ ++G EN+IG + IP+G AGPL ++G E YIP+ATTEG LVAS NRGC AL +
Sbjct: 475 SLVMGACCENVIGYMPIPVGYAGPLLLDGR----ELYIPMATTEGCLVASTNRGCRAL-K 529
Query: 121 AGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKA-VAKVTRHGKLRDVK 179
GV ++++ D MTR P++R P+ R + +W+++ N+ + K +R +L+ +
Sbjct: 530 VSGVTSSVVADGMTRGPVVRFPSIVRTSQAMQWIQDPDNFKKIKEQFDSSSRFARLQRLT 589
Query: 180 PFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNA 239
I G L++RF TGDAMGMNM++ +E +K++++ F D+ L+LSGN C DKKP A
Sbjct: 590 LKIAGRFLFIRFIATTGDAMGMNMLSKGTEYSLKLVQQVFYDMEILSLSGNFCTDKKPAA 649
Query: 240 VNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGN 298
+N+I GRGK+VV EAIVP +I+ LKT + +VN + VGSA AGS GFNAH N
Sbjct: 650 INWIEGRGKSVVCEAIVPAKIISSILKTNVHALVDVNNIQEHVGSAVAGSIGGFNAHAAN 709
Query: 299 IVGAIFLATGQDEAQITEGSHGITIAEV-TPEG-DLYISITMPSLEIGTVGGGTRVPTQR 356
IV AIFLATGQD AQ S+ +T+ E P+G DLYIS TMPS+EIGT+GGGT +P Q
Sbjct: 710 IVTAIFLATGQDPAQNVSSSNCMTLMEPWGPDGEDLYISCTMPSIEIGTIGGGTILPAQS 769
Query: 357 EALSIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
L I+GV G + PG NA + A+IV G VLAGELSL++A+ A HL ++H
Sbjct: 770 ACLDILGVKGSNRENPGANACQLAKIVCGTVLAGELSLMSALTAGHLVKSH 820
>sp|P16393|HMDH_STRPU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|85369|pir||A31898 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - sea urchin
(Strongylocentrotus purpuratus)
>gi|161523|gb|AAA30060.1| (J04200) HMGCoA reductase (EC
1.1.1.34) [Strongylocentrotus purpuratus]
Length = 932
Score = 324 bits (822), Expect = 1e-87
Identities = 177/397 (44%), Positives = 260/397 (64%), Gaps = 14/397 (3%)
Query: 18 IKLHQVEKYVNGDKRLATEIRRKALERKLGIS--LKHIGHYSIDPNELIGRNIENMIGVV 75
I +++E ++ +R +RR+ + + L I+ L+ + + S D + + G EN+IG +
Sbjct: 492 IPAYKLENILDNPER-GVAVRRQIISKLLPITDALEKLPYASYDYSFVSGACCENVIGYM 550
Query: 76 QIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTR 135
+P+GVAGPL ++G+ EF +P+ATTEG LVAS NRGC AL AGG+ + ++ D MTR
Sbjct: 551 PVPVGVAGPLLLDGQ----EFQVPMATTEGCLVASTNRGCRALRSAGGIHSVLIGDGMTR 606
Query: 136 APLIRCPNARRAREVAEW--VKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEF 193
PL+R P+A+ A + +W V EN ++E+ +R KL+ ++ + G ++LRF+
Sbjct: 607 GPLVRLPSAQEAGAIKQWLEVPENFAAIKER-FESTSRFAKLKSIQTALAGRYMFLRFKA 665
Query: 194 ETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAE 253
TGDAMGMNM++ +E+ + ++ FP++ ++LSGN C DKK A+N+I GRGK+VV E
Sbjct: 666 LTGDAMGMNMISKGTEQALHALQTMFPNIEIMSLSGNYCTDKKVAAINWIEGRGKSVVCE 725
Query: 254 AIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEA 312
A VP IV++ LKT+ + ++N KNLVGSA AGS GFNAH NIV AI++ATGQD A
Sbjct: 726 ATVPAHIVQQVLKTSASALVDLNIHKNLVGSAMAGSIGGFNAHAANIVTAIYIATGQDAA 785
Query: 313 QITEGSHGITIAEV--TPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGG-D 369
Q S+ +T+ E GDLY+S TMPS+E+GTVGGGT +P Q L +M V G
Sbjct: 786 QNIASSNCMTLMETRGPKGGDLYLSCTMPSIELGTVGGGTVLPPQSACLQMMDVKGSNIH 845
Query: 370 PPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
G+NA + A IV V+AGELSL++A+AA HL ++H
Sbjct: 846 GSGLNASQLARIVCATVMAGELSLMSALAAGHLVKSH 882
>sp|O74164|HMDH_PICJA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|3341972|dbj|BAA31937.1| (AB012603) HMG-CoA reductase
[Candida utilis]
Length = 934
Score = 323 bits (820), Expect = 2e-87
Identities = 179/418 (42%), Positives = 267/418 (63%), Gaps = 12/418 (2%)
Query: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISL---KHIGHYS 57
+KTL ++++ V G++ L+ +EK + GD A IRRKA+ + + +
Sbjct: 517 VKTLVDDEVVSLVTAGKLPLYALEKQL-GDNLRAVAIRRKAISDLADAPVLRSNKLPYLH 575
Query: 58 IDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSA 117
D + + G EN+IG + +P+GVAGPL I+G+ ++IP+ATTEG LVAS RGC A
Sbjct: 576 YDYDRVFGACCENVIGYMPLPVGVAGPLIIDGK----PYHIPMATTEGCLVASAMRGCKA 631
Query: 118 LTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQ-EKAVAKVTRHGKLR 176
+ GGV T + D MTR P ++ P+ +RA + W+ + + +KA +R +L+
Sbjct: 632 INLGGGVTTVLTKDGMTRGPCVKFPSLKRAGQCKLWLDSDEGQEEMKKAFNSTSRFARLQ 691
Query: 177 DVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEF--PDVRYLALSGNLCVD 234
++ + G+ L++RF TGDAMGMNM++ E +K + E F D+ +++SGN C D
Sbjct: 692 HLQTALAGDLLFIRFRTVTGDAMGMNMISKGVEYALKQMTEVFGWDDMMVVSVSGNYCTD 751
Query: 235 KKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYG-FN 293
KKP AVN+I GRGK+VVAEA +P++ V K LK++ + + +VN KNL+GSA AGS G FN
Sbjct: 752 KKPAAVNWINGRGKSVVAEASIPKDAVVKVLKSSVKAVVDVNVNKNLIGSAMAGSVGGFN 811
Query: 294 AHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVP 353
A N+V A++LA GQD AQ E S+ IT+ T +GDL +S++MPS+E+GT+GGGT +
Sbjct: 812 AQAANMVTAVYLALGQDPAQNVESSNCITLMTETEDGDLKVSVSMPSIEVGTIGGGTILD 871
Query: 354 TQREALSIMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
Q L ++GV G D PG NA++ A+IVA VL+GELSL++A+AA HL ++H R
Sbjct: 872 PQGSMLELLGVRGPADVPGENARQLAKIVASIVLSGELSLVSALAAGHLVQSHMQHNR 929
>pir||T15979 hypothetical protein F08F8.2 - Caenorhabditis elegans
>gi|861367|gb|AAA68386.1| (U28991) coded for by C.
elegans cDNA cm11c3; coded for by C. elegans cDNA
yk34f3.5; similar to hydroxymethylglutaryl-coA
reductase (NADPH) [Caenorhabditis elegans]
Length = 608
Score = 318 bits (807), Expect = 6e-86
Identities = 181/415 (43%), Positives = 258/415 (61%), Gaps = 16/415 (3%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPN 61
K + + + + G+ K ++E ++ A IRR + +K +L ++G+
Sbjct: 155 KDVTPGEAVRLLRRGQAKSRELESRFPAEQ--AIPIRRTFINKKFE-NLPYLGYDYTLAT 211
Query: 62 ELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEA 121
E EN+IG +P+GVAGPL +NG E Y+P+ATTEGAL+AS NRG + + A
Sbjct: 212 ECC---CENVIGYTPVPVGVAGPLTLNGT---SEIYVPMATTEGALIASTNRGMNVIRAA 265
Query: 122 GGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKA---VAKVTRHGKLRDV 178
GGV T+I + MTRAP+++ P AR A + W++ N Q++A +R KL+ +
Sbjct: 266 GGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHPEN--QDRARQEFQSCSRFAKLKSI 323
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
I GN YLRF+ TGDAMGMNM++ + + M+ + E FP++ LALSGNLCVDKK
Sbjct: 324 DITIDGNLAYLRFDAHTGDAMGMNMISKSCDSTMRFLMENFPEMTVLALSGNLCVDKKAA 383
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
A N+ GRG++VVAE ++PRE+V K L+TTPE +A + K +GS++AG+ G NAH
Sbjct: 384 AKNWTEGRGRSVVAECLIPREVVTKTLRTTPEQLAYLTTTKLHIGSSRAGAVGGSNAHAA 443
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQRE 357
NIV AIF+ATGQD AQ+ S T EVT + +LY+S T+P +E+GTVGGGT + QR
Sbjct: 444 NIVAAIFIATGQDAAQVVSSSMCSTRMEVTADKNLYVSCTLPCVEVGTVGGGTILAPQRA 503
Query: 358 ALSIMGVAG-GGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
L +G AG + PG NA++ AE++A VLAGELSL+AA+ L +H L R
Sbjct: 504 CLESLGCAGPNKEQPGQNAERLAEVIAATVLAGELSLMAALTTNELVSSHMKLNR 558
>sp|Q12577|HMDH_GIBFU 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|4376229|emb|CAA63970.1| (X94307) HMG-CoA-reductase
[Gibberella fujikuroi]
Length = 976
Score = 316 bits (802), Expect = 2e-85
Identities = 186/423 (43%), Positives = 256/423 (59%), Gaps = 18/423 (4%)
Query: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALER-KLGISLKHIGHYSID 59
++ + E++I G+I + +EK + GD A +IRR + R K + H S
Sbjct: 513 LREMTDEEVISLSMRGKIPGYALEKTL-GDFTRAVKIRRSIIARNKAAADITHSLDRSKL 571
Query: 60 PNE------LIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNR 113
P E G EN+IG + +P+GVAGPL I+G+ ++IP+ATTEG LVAS +R
Sbjct: 572 PYENYNWERFFGACCENVIGYMPLPVGVAGPLVIDGQ----SYFIPMATTEGVLVASASR 627
Query: 114 GCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRH 172
GC A+ GG +T + D MTR P + RA W+ + +KA +R
Sbjct: 628 GCKAINSGGGAITVLTADGMTRGPCVAFETLERAGAAKLWLDSEAGQDMMKKAFNSTSRF 687
Query: 173 GKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEE--FPDVRYLALSGN 230
+L+ +K + G NLY+RF+ TGDAMGMNM++ E + V+ + F D++ +++SGN
Sbjct: 688 ARLQSMKTALAGTNLYIRFKTTTGDAMGMNMISKGVEHALSVMANDGGFDDMQIISVSGN 747
Query: 231 LCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY 290
C DKK A+N+I GRGK VVAEAI+P E+V LK+ + + E+N KNL+GSA AGS
Sbjct: 748 YCTDKKAAALNWIDGRGKGVVAEAIIPGEVVRSVLKSDVDSLVELNVAKNLIGSAMAGSV 807
Query: 291 -GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGG 349
GFNAH NIV AIFLATGQD AQ+ E ++ ITI + G L IS++MPSLE+GT+GGG
Sbjct: 808 GGFNAHAANIVAAIFLATGQDPAQVVESANCITIMK-NLNGALQISVSMPSLEVGTLGGG 866
Query: 350 TRVPTQREALSIMGVAGGGDP-PGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKM 408
T + Q L I+GV G PG NA++ A I+ AVLAGELSL +A+AA HL RAH
Sbjct: 867 TILEPQGAMLDILGVRGSHPTNPGDNARRLARIIGAAVLAGELSLCSALAAGHLVRAHMQ 926
Query: 409 LGR 411
R
Sbjct: 927 HNR 929
>pir||T41022 3-hydroxy-3-methylglutaryl-coenzyme a reductase - fission yeast
(Schizosaccharomyces pombe) >gi|3218399|emb|CAA19589.1|
(AL023860) 3-hydroxy-3-methylglutaryl-coenzyme a
reductase [Schizosaccharomyces pombe]
Length = 1053
Score = 316 bits (801), Expect = 3e-85
Identities = 178/419 (42%), Positives = 262/419 (62%), Gaps = 14/419 (3%)
Query: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGH---YS 57
+ TLN E++++ +I L+ +E+ + D A IRR + R + Y
Sbjct: 611 ISTLNDEEVVQLTLAKKIPLYALERVLK-DVTRAVVIRRTVVSRSSRTKTLESSNCPVYH 669
Query: 58 IDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSA 117
D + ++ EN+IG + +P+GVAGPL I+G+ FYIP+ATTEGALVAS RGC A
Sbjct: 670 YDYSRVLNACCENVIGYMPLPLGVAGPLIIDGK----PFYIPMATTEGALVASTMRGCKA 725
Query: 118 LTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRHGKLR 176
+ GG VT + D+M+R P + PN RA W+ + +KA +R +L+
Sbjct: 726 INAGGGAVTVLTRDQMSRGPCVAFPNLTRAGRAKIWLDSPEGQEVMKKAFNSTSRFARLQ 785
Query: 177 DVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEE--FPDVRYLALSGNLCVD 234
+K + G L++RF TGDAMGMNM++ E + V+ + F D++ +++SGN C D
Sbjct: 786 HIKTALAGTRLFIRFCTSTGDAMGMNMISKGVEHALVVMSNDAGFDDMQVISVSGNYCTD 845
Query: 235 KKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFN 293
KKP A+N+I GRGK+V+AEAI+P + V+ LKTT E + ++N KNL+GSA AGS GFN
Sbjct: 846 KKPAAINWIDGRGKSVIAEAIIPGDAVKSVLKTTVEDLVKLNVDKNLIGSAMAGSVGGFN 905
Query: 294 AHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVP 353
AH NIV A++LATGQD AQ E S+ IT+ + +G+L +S++MPS+E+GT+GGGT +
Sbjct: 906 AHAANIVTAVYLATGQDPAQNVESSNCITLMD-NVDGNLQLSVSMPSIEVGTIGGGTVLE 964
Query: 354 TQREALSIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
Q L ++GV G PG N+++ A +VA AV+AGELSL +A+A+ HL ++H L R
Sbjct: 965 PQGAMLDLLGVRGAHMTSPGDNSRQLARVVAAAVMAGELSLCSALASGHLVKSHIGLNR 1023
>gi|6323565 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme;
Hmg1p [Saccharomyces cerevisiae]
>gi|123336|sp|P12683|HMD1_YEAST
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1
(HMG-COA REDUCTASE 1) >gi|83081|pir||A30239
hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) I -
yeast (Saccharomyces cerevisiae)
>gi|171686|gb|AAA34676.1| (M22002)
3-hydroxy-3-methyl-glutaryl coenzyme A reductase
[Saccharomyces cerevisiae] >gi|587536|emb|CAA86503.1|
(Z46373) HMG1 gene, len: 1054, CAI: 0.20, HMD1_YEAST
P12683 3-hydroxy-3methylglutaryl-coenzyme A reductase 1
[Saccharomyces cerevisiae]
Length = 1054
Score = 315 bits (799), Expect = 5e-85
Identities = 181/414 (43%), Positives = 262/414 (62%), Gaps = 16/414 (3%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALE---RKLGISLKHIGHYSI 58
K L +++ V +G++ L+ +EK + GD A +RRKAL ++ + + +
Sbjct: 614 KQLKNKEVAALVIHGKLPLYALEKKL-GDTTRAVAVRRKALSILAEAPVLASDRLPYKNY 672
Query: 59 DPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSAL 118
D + + G EN+IG + +P+GV GPL I+G ++IP+ATTEG LVAS RGC A+
Sbjct: 673 DYDRVFGACCENVIGYMPLPVGVIGPLVIDGT----SYHIPMATTEGCLVASAMRGCKAI 728
Query: 119 TEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWV--KENLNYLQEKAVAKVTRHGKLR 176
GG T + D MTR P++R P +R+ W+ +E N ++ KA +R +L+
Sbjct: 729 NAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSEEGQNAIK-KAFNSTSRFARLQ 787
Query: 177 DVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEF--PDVRYLALSGNLCVD 234
++ + G+ L++RF TGDAMGMNM++ E +K + EE+ D+ +++SGN C D
Sbjct: 788 HIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTD 847
Query: 235 KKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFN 293
KKP A+N+I GRGK+VVAEA +P ++V K LK+ + E+N KNLVGSA AGS GFN
Sbjct: 848 KKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLVGSAMAGSVGGFN 907
Query: 294 AHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVP 353
AH N+V A+FLA GQD AQ E S+ IT+ + +GDL IS++MPS+E+GT+GGGT +
Sbjct: 908 AHAANLVTAVFLALGQDPAQNVESSNCITLMKEV-DGDLRISVSMPSIEVGTIGGGTVLE 966
Query: 354 TQREALSIMGVAG-GGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
Q L ++GV G PG NA++ A IVA AVLAGELSL AA+AA HL ++H
Sbjct: 967 PQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGHLVQSH 1020
>sp|Q10283|HMDH_SCHPO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|7450066|pir||S72194 hydroxymethylglutaryl-CoA
reductase (EC 1.1.1.88) - fission yeast
(Schizosaccharomyces pombe) >gi|1374961|gb|AAB39277.1|
(L76979) hydroxymethylglutaryl CoA reductase
[Schizosaccharomyces pombe]
Length = 1053
Score = 314 bits (796), Expect = 1e-84
Identities = 177/419 (42%), Positives = 262/419 (62%), Gaps = 14/419 (3%)
Query: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGH---YS 57
+ TLN E++++ +I L+ +E+ + D A IRR + R + Y
Sbjct: 611 ISTLNDEEVVQLTLAKKIPLYALERVLK-DVTRAVVIRRTVVSRSSRTKTLESSNCPVYH 669
Query: 58 IDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSA 117
D + ++ EN+IG + +P+GVAGPL I+G+ FYIP+ATTEGALVAS RGC A
Sbjct: 670 YDYSRVLNACCENVIGYMPLPLGVAGPLIIDGK----PFYIPMATTEGALVASTMRGCKA 725
Query: 118 LTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRHGKLR 176
+ GG VT + D+M+R P + P+ RA W+ + +KA +R +L+
Sbjct: 726 INAGGGAVTVLTRDQMSRGPCVAFPDLTRAGRAKIWLDSPEGQEVMKKAFNSTSRFARLQ 785
Query: 177 DVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEE--FPDVRYLALSGNLCVD 234
+K + G L++RF TGDAMGMNM++ E + V+ + F D++ +++SGN C D
Sbjct: 786 HIKTALAGTRLFIRFCTSTGDAMGMNMISKGVEHALVVMSNDAGFDDMQVISVSGNYCTD 845
Query: 235 KKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFN 293
KKP A+N+I GRGK+V+AEAI+P + V+ LKTT E + ++N KNL+GSA AGS GFN
Sbjct: 846 KKPAAINWIDGRGKSVIAEAIIPGDAVKSVLKTTVEDLVKLNVDKNLIGSAMAGSVGGFN 905
Query: 294 AHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVP 353
AH NIV A++LATGQD AQ E S+ IT+ + +G+L +S++MPS+E+GT+GGGT +
Sbjct: 906 AHAANIVTAVYLATGQDPAQNVESSNCITLMD-NVDGNLQLSVSMPSIEVGTIGGGTVLE 964
Query: 354 TQREALSIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
Q L ++GV G PG N+++ A +VA AV+AGELSL +A+A+ HL ++H L R
Sbjct: 965 PQGAMLDLLGVRGAHMTSPGDNSRQLARVVAAAVMAGELSLCSALASGHLVKSHIGLNR 1023
>gi|6323483 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme;
Hmg2p [Saccharomyces cerevisiae]
>gi|123338|sp|P12684|HMD2_YEAST
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2
(HMG-COA REDUCTASE 2) >gi|83082|pir||B30239
hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) II -
yeast (Saccharomyces cerevisiae)
>gi|171688|gb|AAA34677.1| (M22255) 3-hydroxy-3-methyl
glutaryl coenzyme A reductase [Saccharomyces cerevisiae]
>gi|717061|gb|AAB67527.1| (U22382) Hmg2p:
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase
[Saccharomyces cerevisiae]
Length = 1045
Score = 311 bits (789), Expect = 8e-84
Identities = 182/416 (43%), Positives = 263/416 (62%), Gaps = 18/416 (4%)
Query: 1 MKTLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKAL----ERKLGISLKHIGHY 56
+K +N ++ V NG++ L+ +EK + R A +RRKAL E + +S K +
Sbjct: 609 LKNMNNTEVSNLVVNGKLPLYSLEKKLEDTTR-AVLVRRKALSTLAESPILVSEK-LPFR 666
Query: 57 SIDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCS 116
+ D + + G EN+IG + IP+GV GPL I+G ++IP+ATTEG LVAS RGC
Sbjct: 667 NYDYDRVFGACCENVIGYMPIPVGVIGPLIIDGT----SYHIPMATTEGCLVASAMRGCK 722
Query: 117 ALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWV--KENLNYLQEKAVAKVTRHGK 174
A+ GG T + D MTR P++R P R+ W+ +E N ++ KA +R +
Sbjct: 723 AINAGGGATTVLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIK-KAFNSTSRFAR 781
Query: 175 LRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEF--PDVRYLALSGNLC 232
L+ ++ + G+ L++RF TGDAMGMNM++ E +K + EE+ D+ +++SGN C
Sbjct: 782 LQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYC 841
Query: 233 VDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-G 291
DKKP A+N+I GRGK+VVAEA +P ++V+ LK+ + E+N KNLVGSA AGS G
Sbjct: 842 TDKKPAAINWIEGRGKSVVAEATIPGDVVKSVLKSDVSALVELNISKNLVGSAMAGSVGG 901
Query: 292 FNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTR 351
FNAH N+V A+FLA GQD AQ E S+ IT+ + +GDL IS++MPS+E+GT+GGGT
Sbjct: 902 FNAHAANLVTALFLALGQDPAQNVESSNCITLMKEV-DGDLRISVSMPSIEVGTIGGGTV 960
Query: 352 VPTQREALSIMGVAG-GGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
+ Q L ++GV G PG NA++ A I+A AVLAGELSL +A+AA HL ++H
Sbjct: 961 LEPQGAMLDLLGVRGPHPTEPGANARQLARIIACAVLAGELSLCSALAAGHLVQSH 1016
>gb|AAD47596.1| (AF142473) HMG-CoA reductase [Artemisia annua]
Length = 567
Score = 305 bits (773), Expect = 6e-82
Identities = 172/412 (41%), Positives = 259/412 (62%), Gaps = 10/412 (2%)
Query: 5 NVEDIIEK-VANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNEL 63
N +D+I K V +GE+ + +E + GD A +IR++A+ER +G + +G D +
Sbjct: 149 NDDDVIVKSVVSGEVNSYSLEASL-GDCYRAAKIRKRAVERIVGREVLGLGFEGFDYESI 207
Query: 64 IGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGG 123
+G+ E IG VQ+P+GVAGPL +NG GEF +P+ATTEG LVAS NRGC A+ +GG
Sbjct: 208 LGQCCEMPIGYVQVPVGVAGPLLLNG----GEFMVPMATTEGCLVASTNRGCKAICLSGG 263
Query: 124 VVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFI 182
+L D MTRAP++R A RA ++ ++++ +N+ V K +R +L++++ I
Sbjct: 264 ATAILLKDGMTRAPVVRFATAERASQLKFYLEDGVNFDTLSVVFNKSSRFARLQNIQCSI 323
Query: 183 VGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNF 242
G NLY+RF TGDAMGMNMV+ + ++ ++ +FPD+ + +S C DKKP AVN+
Sbjct: 324 AGKNLYIRFTCSTGDAMGMNMVSKGVQNVLDFLQNDFPDMDVIGISWKFCSDKKPTAVNW 383
Query: 243 ILGRGKTVVAEAIVPREIVEKK-LKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVG 301
I GRGK+VV +A++ +++V K L + + L+ H +IV
Sbjct: 384 IEGRGKSVVFQAVITKKVVRKSALNPQTCTCRTLTCLRPLLVLLLLVLLVDLMHMLHIVS 443
Query: 302 AIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALS 360
A+F+ATGQD AQ E SH IT+ E G DL++++TMPS+E+GTVGGGT++ +Q L+
Sbjct: 444 AVFIATGQDPAQNIESSHCITMMEAVNNGKDLHVNVTMPSIEVGTVGGGTQLASQSACLN 503
Query: 361 IMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
++GV G + PG NA+ A IVAG+VLAGELSL++AI+A L ++H R
Sbjct: 504 LLGVKGACIESPGSNAQLLARIVAGSVLAGELSLMSAISAGQLVKSHMKYNR 555
>sp|Q9Y7D2|HMDH_ASPTE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|4959949|gb|AAD34556.1| (AF141925)
hydroxymethylglutaryl-coenzyme A reductase [Aspergillus
terreus]
Length = 1068
Score = 305 bits (772), Expect = 8e-82
Identities = 182/435 (41%), Positives = 257/435 (58%), Gaps = 30/435 (6%)
Query: 2 KTLNVEDIIEKVANGEIKLHQVEKYVN----GDKRLATE---------IRRKALERK--- 45
++L ++++E G+I + +EK + G R T IRR A+ +
Sbjct: 585 ESLTDDELVELCLRGKIAGYSLEKTLERIAAGSSRSVTRLEAFTRAVRIRRAAVSKTPST 644
Query: 46 ----LGISLKHIGHYSIDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLA 101
G++ + + + + G EN++G + +P+GVAGP+ I+G+ +IP+A
Sbjct: 645 QNLCSGLAESLLPYRDYNYELVHGACCENVVGYLPLPLGVAGPMVIDGQ----ALFIPMA 700
Query: 102 TTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYL 161
TTEG LVAS +RGC A+ GG T + D MTR P +R P+A+RA E WV+ L +
Sbjct: 701 TTEGVLVASASRGCKAINAGGGATTMLKGDGMTRGPCLRFPSAQRAAEAQRWVESPLGHE 760
Query: 162 QEKAVAKVT-RHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEE-- 218
A T R +L+ + G LY+RF TGDAMGMNM++ E+ ++ + E
Sbjct: 761 VLAAAFNATSRFARLQTLTVAQAGIYLYIRFRTTTGDAMGMNMISKGVEKALEAMAAEGG 820
Query: 219 FPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYF 278
FPD+ + LSGN C DKK A+N+I GRGK+V+AEA +P E V + LKT + + E+N
Sbjct: 821 FPDMHTVTLSGNFCSDKKSAAINWIGGRGKSVIAEATIPAETVRQVLKTDVDALVELNTA 880
Query: 279 KNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISIT 337
KNLVGSA AGS GFNAH N+V A+FLATGQD AQ E S IT + +G+L+I+++
Sbjct: 881 KNLVGSAMAGSLGGFNAHASNLVQAVFLATGQDPAQNVESSSCITTMK-NIDGNLHIAVS 939
Query: 338 MPSLEIGTVGGGTRVPTQREALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAA 396
MPS+E+GT+GGGT + Q L ++GV G PG NA++ A IVA AVLAGELS AA
Sbjct: 940 MPSMEVGTIGGGTILEAQGAMLDLLGVRGAHSTEPGANARRLARIVAAAVLAGELSTCAA 999
Query: 397 IAAKHLARAHKMLGR 411
+AA HL AH R
Sbjct: 1000 LAAGHLVNAHMQHNR 1014
>gb|AAF56175.1| (AE003744) Hmgcr gene product [Drosophila melanogaster]
Length = 920
Score = 303 bits (767), Expect = 3e-81
Identities = 180/413 (43%), Positives = 250/413 (59%), Gaps = 16/413 (3%)
Query: 4 LNVEDIIEKVANG--EIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIG---HYSI 58
L+ E+I+ V G LH++E ++ +R IRR+ + + + + + +
Sbjct: 486 LSDEEIVSIVHAGGTHCPLHKIESVLDDPER-GVRIRRQIIGSRAKMPVGRLDVLPYEHF 544
Query: 59 DPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSAL 118
D +++ EN++G V IP+G AGPL ++GE +Y+P+ATTEGALVAS NRGC AL
Sbjct: 545 DYRKVLNACCENVLGYVPIPVGYAGPLLLDGE----TYYVPMATTEGALVASTNRGCKAL 600
Query: 119 TEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVT-RHGKLRD 177
+ GV + + D MTRAP +R P+ RA E W++ + NY K T R G+L+D
Sbjct: 601 S-VRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKD 659
Query: 178 VKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKP 237
+ G LY+RF TGDAMGMNMV+ +E ++ I+ +FPD++ ++LSGN C DKKP
Sbjct: 660 CHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKP 719
Query: 238 NAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHF 296
A+N+I GRGK VV E + + LKT + + E N KN+ GSA AGS G NAH
Sbjct: 720 AAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHA 779
Query: 297 GNIVGAIFLATGQDEAQITEGSHGITIAEVTPEG--DLYISITMPSLEIGTVGGGTRVPT 354
N+V A+FLATGQD AQ S+ T E E DLY++ TMPSLE+GTVGGGT +P
Sbjct: 780 ANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPG 839
Query: 355 QREALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
Q L ++GV G PG NAKK A+IV V+AGELSL+AA+ L ++H
Sbjct: 840 QSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSH 892
>sp|O76819|HMDH_AGRIP 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|3341396|emb|CAA08775.1| (AJ009675)
3-hydroxy-3-methylgluraryl coenzyme A reductase [Agrotis
ipsilon]
Length = 833
Score = 300 bits (761), Expect = 1e-80
Identities = 173/411 (42%), Positives = 252/411 (61%), Gaps = 14/411 (3%)
Query: 3 TLNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLG--ISLKHIGHYSIDP 60
+L+ E+++ V I LH++E V GD +RRK + + +++K + + + D
Sbjct: 406 SLSDEEVVMLVEQSHIPLHRLEA-VLGDPLRGVRLRRKVVGARFQTELAIKQLPYLNYDY 464
Query: 61 NELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTE 120
++++ EN+IG V +P+G AGPL ++G+ + IP+ATTEGALVAS NRG A+
Sbjct: 465 SKVLNACCENVIGYVGVPVGYAGPLVVDGK----PYMIPMATTEGALVASTNRGAKAIGI 520
Query: 121 AGGVVTTILDDK-MTRAPLIRCPNARRAREVAEWVKENLNY-LQEKAVAKVTRHGKLRDV 178
G VT++++D MTRAP I+ PN RA E +W+ NY + ++A +R +L+++
Sbjct: 521 RG--VTSVVEDVGMTRAPAIKLPNVVRAHECRQWIDNKDNYAVIKEAFDSTSRFARLQEI 578
Query: 179 KPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPN 238
+ G LYLRF TGDAMGMNMV+ +E +K+++ FPD+ ++LSGN C DKK
Sbjct: 579 HIGVDGATLYLRFRATTGDAMGMNMVSKGAENALKLLKNYFPDMEVISLSGNYCSDKKAA 638
Query: 239 AVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFG 297
A+N++ GRGK VV E + + + KT + +A N KNL GSA AGS G NAH
Sbjct: 639 AINWVKGRGKRVVCETTITSDSLRTIFKTDAKTLARCNKIKNLSGSALAGSIGGNNAHAA 698
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVTPEG--DLYISITMPSLEIGTVGGGTRVPTQ 355
N+V AI++ATGQD AQ S+ T EV E DLY++ TMPSLE+GTVGGGT + Q
Sbjct: 699 NMVTAIYIATGQDPAQNVTSSNCSTNMEVCGENGEDLYVTCTMPSLEVGTVGGGTILTGQ 758
Query: 356 REALSIMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
L I+GV G G P N+ + A ++ VLAGELSL+AA+ L ++H
Sbjct: 759 GACLDILGVKGAGARPAENSARLASLICATVLAGELSLMAALVNSDLVKSH 809
>sp|P14773|HMDH_DROME 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|422429|pir||S32572 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - fruit fly (Drosophila
melanogaster) >gi|157624|gb|AAA28608.1| (M21329)
3-hydroxy-3-methylglutaryl coenzyme A reductase
[Drosophila melanogaster]
Length = 916
Score = 293 bits (742), Expect = 3e-78
Identities = 178/413 (43%), Positives = 243/413 (58%), Gaps = 16/413 (3%)
Query: 4 LNVEDIIEKVANG--EIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIG---HYSI 58
L+ E+I+ V G LH++E ++ +R IRR+ + + + + + +
Sbjct: 482 LSDEEIVSIVHAGGTHCPLHKIESVLDDPER-GVRIRRQIIGSRAKMPVGRLDVLPYEHF 540
Query: 59 DPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSAL 118
D +++ EN++G V IP+G AGPL ++GE +Y+P+ATTEGALVAS NRGC AL
Sbjct: 541 DYRKVLNACCENVLGYVPIPVGYAGPLLLDGE----TYYVPMATTEGALVASTNRGCKAL 596
Query: 119 TEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVT-RHGKLRD 177
+ GV + + D MTRAP +R P+ RA E W++ + NY K T R G+L+D
Sbjct: 597 S-VRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKD 655
Query: 178 VKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKP 237
+ G LY+RF TGD MGMNMV+ A FPD++ ++LSGN C DKKP
Sbjct: 656 CHIAMDGPQLYIRFVAITGDRMGMNMVSKALRWPFAEFTLHFPDMQIISLSGNFCCDKKP 715
Query: 238 NAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHF 296
A+N+I GRGK VV E + + LKT + + E N KN+ GSA AGS G NAH
Sbjct: 716 AAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHA 775
Query: 297 GNIVGAIFLATGQDEAQITEGSHGITIAEVTPEG--DLYISITMPSLEIGTVGGGTRVPT 354
N+V A+FLATGQD AQ S+ T E E DLY++ TMPSLE+GTVGGGT +P
Sbjct: 776 ANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPG 835
Query: 355 QREALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAH 406
Q L ++GV G PG NAKK A+IV V+AGELSL+AA+ L ++H
Sbjct: 836 QSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSH 888
>pir||G82425 3-hydroxy-3-methylglutaryl CoA reductase VCA0723 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9658143|gb|AAF96622.1| (AE004401)
3-hydroxy-3-methylglutaryl CoA reductase [Vibrio
cholerae]
Length = 436
Score = 285 bits (722), Expect = 6e-76
Identities = 152/347 (43%), Positives = 217/347 (61%), Gaps = 8/347 (2%)
Query: 66 RNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVV 125
+NIE IG V++P+G+AGPL++NG +A+G++ +PLATTE ALVAS +RG +T AGG
Sbjct: 97 KNIEYFIGTVKLPVGIAGPLRVNGSHAQGDYLVPLATTEAALVASYHRGSQLITAAGGAS 156
Query: 126 TTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGN 185
+L++ +TR P+ + +A + WV ++E A + T HGKL+D++ I GN
Sbjct: 157 ALLLNEGVTRTPVFAFLSLAQAGQFVGWVTSQFEQMKEIAQS-TTAHGKLKDIQVNIEGN 215
Query: 186 NLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLA-LSGNLCVDKKPNAVNFIL 244
++YL FE+ TGDA G NMVTIA+ + + I P A L GNL DKK N+
Sbjct: 216 HVYLVFEYTTGDASGQNMVTIATHAVFEFIMRHSPVAPVQAFLDGNLSGDKKANSYTLRS 275
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIF 304
RGK V AE + E+V+K L TTPE + + VG A +G+ G NAH+ N + A++
Sbjct: 276 VRGKKVSAEVHLSAELVKKYLHTTPEQMVQFGQMTT-VGGALSGAIGVNAHYANALAALY 334
Query: 305 LATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGV 364
+A GQD A + E + G+T E+ P G LY S+T+P+L +GTVGGGT +P+Q LS+MG+
Sbjct: 335 IACGQDAACVAESAIGMTRMEIHPHGGLYASVTLPNLMVGTVGGGTHLPSQHACLSLMGL 394
Query: 365 AGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
AG G +A+ AE+ A LAGELS++ A A H +RAH L R
Sbjct: 395 AGQG-----HARALAEVAAALCLAGELSIVGAFCAGHFSRAHHKLAR 436
>gb|AAC15476.1| (AF034761) 3-hydroxy-3-methylglutaryl coenzyme A reductase [Tagetes
erecta]
Length = 483
Score = 273 bits (690), Expect = 3e-72
Identities = 146/304 (48%), Positives = 200/304 (65%), Gaps = 6/304 (1%)
Query: 29 GDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGRNIENMIGVVQIPMGVAGPLKIN 88
GD + A IRR+ALE+ G SL + D + ++G+ E +G VQIP+G+AGPL +N
Sbjct: 178 GDCKRAASIRREALEQITGKSLSGLPLEGFDYDSILGQCCEMPVGYVQIPVGIAGPLLLN 237
Query: 89 GEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAR 148
G EF +P+ATTEG LVAS NRGC A+ +GG +L D MTRAP++R A+RA
Sbjct: 238 GT----EFSVPMATTEGCLVASTNRGCKAIYISGGATCILLKDGMTRAPVVRFGTAKRAA 293
Query: 149 EVAEWVKENLNYLQEKAVA-KVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIA 207
E+ +++++ +N+ V K +R G+L+ V+ I G N Y RF TGDAMGMNMVT
Sbjct: 294 ELKQFLEDPMNFDTLAVVFNKSSRFGRLQSVQCAIAGKNXYNRFCCATGDAMGMNMVTKG 353
Query: 208 SEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKT 267
+ ++ ++ +FPD+ + +SGN C DKKP A+N+I GRGK+VV EAI+ E+V+K LKT
Sbjct: 354 VQNVLDFLQHDFPDMDVMGISGNYCSDKKPAAINWIEGRGKSVVCEAIIKEEVVQKVLKT 413
Query: 268 TPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEV 326
T + E+N KNL GSA AG+ GFNAH NIV A++LATGQD AQ E SH IT+ E
Sbjct: 414 TVPALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYLATGQDPAQNVESSHCITMMEA 473
Query: 327 TPEG 330
+G
Sbjct: 474 VNDG 477
>sp|P16237|HMDH_SCHMA 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|102447|pir||A34416 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - fluke (Schistosoma
mansoni) >gi|161021|gb|AAA29896.1| (M27294)
3-hydroxy-3-methylglutaryl coenzyme A reductase
[Schistosoma mansoni]
Length = 948
Score = 268 bits (677), Expect = 1e-70
Identities = 161/415 (38%), Positives = 242/415 (57%), Gaps = 17/415 (4%)
Query: 4 LNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGIS--LKHIGHYSIDPN 61
L+ +I++ +++G +K ++E V R A E+RR L L ++ I + D
Sbjct: 470 LSDTEILQLLSHGRLKTRELESVVRNPFR-AVELRRLDLSTFLNNPHIIERIPYKDYDYR 528
Query: 62 ELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEA 121
+ G+ E +IG + IP+G GPL ++G YIPLATTEG LVAS NRGC A+ A
Sbjct: 529 LVYGQCCEEVIGYMPIPVGKIGPLLLDGR----SHYIPLATTEGCLVASTNRGCRAIFLA 584
Query: 122 GGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEK-AVAKVTRHGKLRDVKP 180
GG+ + + D+MTRAP++ P+ + + W+ + K A K + H L V
Sbjct: 585 GGIKSVVYRDQMTRAPVVWFPSIIDSVKCIAWIDSEEGFQTLKSAFDKTSAHVNLLSVFA 644
Query: 181 FIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAV 240
G +++RF TGDAMGMNMV+ A++ + +++ F +++ ++LSGN+C DKKP +
Sbjct: 645 CPAGRYIHIRFAARTGDAMGMNMVSKATDSALHCLKKYFSNMQVISLSGNMCTDKKPATI 704
Query: 241 NFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQA---GSYGFNAHFG 297
N ILGRGK+V+AEA + +++ + L T + +A + + KN +GSA A G G NAH
Sbjct: 705 NTILGRGKSVIAEAHLSADVLAQVLHTNAQRLARLTHSKNWIGSAMAGCPGMMGCNAHAA 764
Query: 298 NIVGAIFLATGQDEAQITEGSHGITIAEVTPEGD-LYISITMPSLEIGTVGGGTRVPTQR 356
NI+ +F ATGQD AQ+ + S +T EV D L S+TMP LE+GTVGGGTR+ QR
Sbjct: 765 NIIAGMFAATGQDLAQVVDSSSCLTQLEVDLSDDSLVASVTMPCLEVGTVGGGTRLSGQR 824
Query: 357 EALSIMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
L ++ ++ D P + + I+AG VLA ELSL+AA+ L +AH R
Sbjct: 825 ACLDLLDLS--VDRP---TEHLSRIIAGTVLAAELSLMAALDTDDLVKAHMHFNR 874
>dbj|BAA70975.1| (AB013457) 3-hydroxy-3-methylglutaryl coenzyme A reductase
[Streptomyces sp.] >gi|9695274|dbj|BAB07794.1|
(AB037666) 3-hydroxy-3-methylglutaryl CoA reductase
[Streptomyces sp. CL190]
Length = 353
Score = 251 bits (634), Expect = 1e-65
Identities = 149/342 (43%), Positives = 208/342 (60%), Gaps = 8/342 (2%)
Query: 74 VVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGC--SALTEAGGVVTTILDD 131
+ +PM GPL+I+G A+ E +PLAT E L SV RG S LTE G +V T++D+
Sbjct: 7 IAGVPMRWVGPLRISGNVAETETQVPLATYESPLWPSVGRGAKVSRLTEKG-IVATLVDE 65
Query: 132 KMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRF 191
+MTR+ ++ +A+ A A+ + ++ L+E V +R +L ++K I N L++RF
Sbjct: 66 RMTRSVIVEATDAQTAYMAAQTIHARIDELRE-VVRGCSRFAQLINIKHEINANLLFIRF 124
Query: 192 EFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVV 251
EF TGDA G NM T+AS+ ++ + E P + Y ++SGN C DKK A+N ILGRGK V+
Sbjct: 125 EFTTGDASGHNMATLASDVLLGHLLETIPGISYGSISGNYCTDKKATAINGILGRGKNVI 184
Query: 252 AEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQD 310
E +VPR++VE L TT I E+N KNL+G+ AG NAHF N++ +LATGQD
Sbjct: 185 TELLVPRDVVENNLHTTAAKIVELNIRKNLLGTLLAGGIRSANAHFANMLLGFYLATGQD 244
Query: 311 EAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGGDP 370
A I EGS G+ +AE +GDLY + T+P+L +GTVG G + L+ +G +
Sbjct: 245 AANIVEGSQGVVMAE-DRDGDLYFACTLPNLIVGTVGNGKGLGFVETNLARLGCRADRE- 302
Query: 371 PGVNAKKFAEIVAGAVLAGELSLLAA-IAAKHLARAHKMLGR 411
PG NA++ A I A VL GELSLLAA L RAH L R
Sbjct: 303 PGENARRLAVIAAATVLCGELSLLAAQTNPGELMRAHVQLER 344
>gb|AAB23278.1| 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMGR {active site}
[tomatoes, cultivar VFNT cherry LA1221, Peptide Partial,
249 aa]
Length = 249
Score = 250 bits (631), Expect = 3e-65
Identities = 128/247 (51%), Positives = 174/247 (69%), Gaps = 3/247 (1%)
Query: 168 KVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLAL 227
K +R +L+ ++ I G NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +
Sbjct: 3 KSSRFARLQGIQCAIAGKNLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQSEYPDMDVIGI 62
Query: 228 SGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQA 287
SGN C DKKP AVN+I GRGK+VV EAI+ ++V+K LKT + E+N KNL GSA A
Sbjct: 63 SGNFCSDKKPAAVNWIEGRGKSVVCEAIIKEDVVKKVLKTEVAALVELNMLKNLTGSAMA 122
Query: 288 GSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGT 345
G+ GFNAH NIV A++LATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GT
Sbjct: 123 GALGGFNAHASNIVSAVYLATGQDPAQNVESSHCITMMEAVNDGKDLHISVTMPSIEVGT 182
Query: 346 VGGGTRVPTQREALSIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLAR 404
VGGGT++ +Q L+++GV G D PG NA+ A IVAG+VLAGELSL++AI+A L +
Sbjct: 183 VGGGTQLASQSACLNLLGVKGANRDAPGSNARLLATIVAGSVLAGELSLMSAISAGQLVK 242
Query: 405 AHKMLGR 411
+H R
Sbjct: 243 SHMKYNR 249
>dbj|BAA74565.1| (AB015626) 3-hydroxy-3-methylglutaryl coenzyme A reductase
[Streptomyces griseolosporeus]
>gi|9711350|dbj|BAB07821.1| (AB037907) HMG-CoA reductase
[Streptomyces griseolosporeus]
Length = 353
Score = 249 bits (630), Expect = 3e-65
Identities = 150/339 (44%), Positives = 207/339 (60%), Gaps = 8/339 (2%)
Query: 77 IPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGC--SALTEAGGVVTTILDDKMT 134
+PM GP++I+G A E +PLAT E L SV RG S LTE G +V T++D++MT
Sbjct: 10 VPMRWVGPVRISGNVATIETQVPLATYESPLWPSVGRGAKVSRLTEKG-IVATLVDERMT 68
Query: 135 RAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFE 194
R+ L+ +A A A ++ ++ L+E V +R +L ++ I GN L++RFEF
Sbjct: 69 RSVLVEATDALTALSAARTIEARIDELRE-LVRGCSRFAQLIGIRHEITGNLLFVRFEFS 127
Query: 195 TGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEA 254
TGDA G NM T+AS+ +++ + E P + Y ++SGN C DKK A+N ILGRGK VV E
Sbjct: 128 TGDASGHNMATLASDVLLQHLLETVPGISYGSISGNYCTDKKATAINGILGRGKNVVTEL 187
Query: 255 IVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQ 313
+VPR++V L TT IAE+N KNL+G+ AG NAH+ N++ A +LATGQD A
Sbjct: 188 LVPRDVVADVLNTTAAKIAELNLRKNLLGTLLAGGIRSANAHYANMLLAFYLATGQDAAN 247
Query: 314 ITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGGDPPGV 373
I EGS G+ AE +GDLY++ T+P+L +GTVG G + L+ +G + PG
Sbjct: 248 IVEGSQGVVTAE-DRDGDLYLACTLPNLIVGTVGNGKGLGFVETNLNRLGCRADRE-PGE 305
Query: 374 NAKKFAEIVAGAVLAGELSLLAA-IAAKHLARAHKMLGR 411
NA++ A I A VL GELSLLAA L RAH L R
Sbjct: 306 NARRLAVIAAATVLCGELSLLAAQTNPGELMRAHVQLER 344
>pir||PQ0187 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - tomato
(fragment)
Length = 249
Score = 248 bits (627), Expect = 8e-65
Identities = 127/247 (51%), Positives = 174/247 (70%), Gaps = 3/247 (1%)
Query: 168 KVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLAL 227
K +R +L+ ++ I G NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +
Sbjct: 3 KSSRFARLQGIQCAIAGKNLYMRFSCSTGDAMGMNMVSKGVQNVLDYLQSEYPDMDVIGI 62
Query: 228 SGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQA 287
SGN C DKKP AVN+I GRGK+VV +AI+ ++V+K LKT + E+N KNL GSA A
Sbjct: 63 SGNFCSDKKPAAVNWIEGRGKSVVCKAIIKEDVVKKVLKTEVAALVELNMLKNLTGSAMA 122
Query: 288 GSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGT 345
G+ GFNAH NIV A++LATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GT
Sbjct: 123 GALGGFNAHASNIVSAVYLATGQDPAQNVESSHCITMMEAVNDGKDLHISVTMPSIEVGT 182
Query: 346 VGGGTRVPTQREALSIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLAR 404
VGGGT++ +Q L+++GV G D PG NA+ A IVAG+VLAGELSL++AI+A L +
Sbjct: 183 VGGGTQLASQSACLNLLGVKGANRDAPGSNARLLATIVAGSVLAGELSLMSAISAGQLVK 242
Query: 405 AHKMLGR 411
+H R
Sbjct: 243 SHMKYNR 249
>pir||S59945 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - potato
(fragment)
Length = 243
Score = 241 bits (609), Expect = 1e-62
Identities = 123/233 (52%), Positives = 165/233 (70%), Gaps = 3/233 (1%)
Query: 182 IVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVN 241
I G NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN
Sbjct: 5 IAGKNLYMRFVCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVN 64
Query: 242 FILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIV 300
+I GRGK+VV EAI+ E+V+K LKT + E+N KN+ GSA AG+ GFNAH NIV
Sbjct: 65 WIEGRGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNVTGSAMAGALGGFNAHASNIV 124
Query: 301 GAIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREAL 359
A+F+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L
Sbjct: 125 SAVFIATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACL 184
Query: 360 SIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+++GV G + PG NA+ A +VAG+VLAGELSL++AI+A L +H R
Sbjct: 185 NLLGVKGANREAPGSNARLLATVVAGSVLAGELSLMSAISAGQLVNSHMKYNR 237
>gb|AAC72378.1| (AF096838) 3-hydroxy-3-methylglutaryl coenzyme A reductase [Solanum
tuberosum]
Length = 255
Score = 241 bits (608), Expect = 1e-62
Identities = 123/233 (52%), Positives = 164/233 (69%), Gaps = 3/233 (1%)
Query: 182 IVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVN 241
I G NLY+RF TGDAMGMNMV+ + ++ ++ E+PD+ + +SGN C DKKP AVN
Sbjct: 13 IAGKNLYMRFVCSTGDAMGMNMVSKGVQNVLDYLQNEYPDMDVIGISGNFCSDKKPAAVN 72
Query: 242 FILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIV 300
+I GRGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV
Sbjct: 73 WIEGRGKSVVCEAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIV 132
Query: 301 GAIFLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREAL 359
+F+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L
Sbjct: 133 STVFIATGQDPAQNIESSHCITMMEAVNDGKDLHISVTMPSIEVGTVGGGTQLASQSACL 192
Query: 360 SIMGVAGGG-DPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
+++GV G + PG NA+ A +VAG+VLAGELSL++AI+A L +H R
Sbjct: 193 NLLGVKGANREAPGSNARLLATVVAGSVLAGELSLMSAISAGQLVNSHMKYNR 245
>dbj|BAA74566.1| (AB015627) 3-hydroxy-3-methylglutaryl coenzyme A reductase
[Streptomyces sp.]
Length = 353
Score = 238 bits (600), Expect = 1e-61
Identities = 142/341 (41%), Positives = 199/341 (57%), Gaps = 6/341 (1%)
Query: 74 VVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCS-ALTEAGGVVTTILDDK 132
+ +PM GPL+I+G A E ++PLAT E L SV RG ++ G+ T++D++
Sbjct: 7 IAMVPMKWVGPLRISGNVATTETHVPLATYETPLWPSVGRGAKVSMLSERGIAATLVDER 66
Query: 133 MTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFE 192
MTR+ L+ +A+ A A ++ + L+ V +R +L V+ I GN L++RFE
Sbjct: 67 MTRSVLVEATDAQTAYTAARAIEARIEELRA-VVRTCSRFAELLQVRHEIAGNLLFVRFE 125
Query: 193 FETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVA 252
F T G NM T+AS+ ++ + + P + Y ++SGN C DKK A+N ILGRGK VV
Sbjct: 126 FSTRRPSGHNMATLASDALLAHLLQTIPGISYGSISGNYCTDKKATAINGILGRGKNVVT 185
Query: 253 EAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDE 311
E +V RE+VE+ L TT I E+N KNL+G+ AG NAH+ N++ +LATGQD
Sbjct: 186 ELVVEREVVERVLHTTAAKIVELNIRKNLLGTLLAGGIRSANAHYANMLLGFYLATGQDA 245
Query: 312 AQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGGDPP 371
A I EGS G+T+AE +GDLY S +P+L +GTVG G + L+ +G P
Sbjct: 246 ANIVEGSQGVTLAE-DRDGDLYFSCNLPNLIVGTVGNGKGLEFVETNLNRLG-CREDRAP 303
Query: 372 GVNAKKFAEIVAGAVLAGELSLLAA-IAAKHLARAHKMLGR 411
G NA++ A I A VL GELSLLAA L RAH L R
Sbjct: 304 GENARRLAVIAAATVLCGELSLLAAQTNPGELMRAHVELER 344
>gb|AAF80475.1|AF162705_1 (AF162705) 3-hydroxy-3-methylglutaryl coenzyme A reductase
[Anthonomus grandis]
Length = 247
Score = 213 bits (536), Expect = 4e-54
Identities = 117/219 (53%), Positives = 151/219 (68%), Gaps = 4/219 (1%)
Query: 197 DAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIV 256
+AMGMNM++ +E+ + I+ F D+ L+LSGN+C DKKP+A+N+I GRGK+VV EAIV
Sbjct: 1 EAMGMNMISKGTEKSLAYIKSHFEDMEILSLSGNVCTDKKPSAINWIEGRGKSVVCEAIV 60
Query: 257 PREIVEKKLKTTPELIAEVNYFKNLVGSA-QAGSYGFNAHFGNIVGAIFLATGQDEAQIT 315
P IV LKTT + ++N KN+VGSA A GFNAH NIV AI++ATGQD AQ
Sbjct: 61 PANIVHSILKTTTHALVDLNISKNMVGSAVSAAIGGFNAHAANIVTAIYIATGQDVAQNV 120
Query: 316 EGSHGITIAEVTPE--GDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGG-GDPPG 372
S+ IT+ E + DL IS TMPS+EIGTVGGGT +P Q L ++GV G + PG
Sbjct: 121 GSSNCITLMEPCGDKGEDLLISCTMPSVEIGTVGGGTVLPAQGACLEMLGVKGAHSENPG 180
Query: 373 VNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
NAK+ A+IV GAVLAGELSL+AA+ HL ++H L R
Sbjct: 181 DNAKQLAKIVCGAVLAGELSLMAALVTGHLVKSHLRLNR 219
>pir||S33175 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - rat
(fragment) >gi|296925|emb|CAA39001.1| (X55286)
hydroxymethylglutaryl-CoA reductase (NADPH) [Rattus
norvegicus]
Length = 244
Score = 211 bits (532), Expect = 1e-53
Identities = 113/220 (51%), Positives = 153/220 (69%), Gaps = 4/220 (1%)
Query: 196 GDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAI 255
G +MGMNM++ +E+ + ++E FP+++ LA+SGN C DKKP A+N+I GRGKTVV EA+
Sbjct: 8 GTSMGMNMISKGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAV 67
Query: 256 VPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQI 314
+P ++V + LK+T E + +VN KNLVGSA AGS G+NAH NIV AI++A QD AQ
Sbjct: 68 IPAKVVREVLKSTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACAQDAAQN 127
Query: 315 TEGSHGITIAEVTPEG--DLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGG-GDPP 371
S+ IT+ E + DL S MPS+EIGTVGGGT + Q+ L ++GV G D P
Sbjct: 128 VGSSNCITLMEASGPXXEDLXXSXXMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNP 187
Query: 372 GVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR 411
G NA++ A IV G V+AGELSL+AA+AA HL R+H + R
Sbjct: 188 GENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNR 227
>sp|Q01237|HMDH_MOUSE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|193882|gb|AAA37819.1| (M62766) HMG-CoA reductase
[Mus musculus]
Length = 224
Score = 210 bits (530), Expect = 2e-53
Identities = 113/207 (54%), Positives = 147/207 (70%), Gaps = 4/207 (1%)
Query: 209 EEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTT 268
E+ + ++E FPD++ LA+SGN C DKKP A+N+I GRGKTVV EA++P ++V + LKTT
Sbjct: 1 EKALLKLQEFFPDMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTT 60
Query: 269 PELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVT 327
E + +VN KNLVGSA AGS G+NAH NIV AI++A GQD AQ S+ IT+ E +
Sbjct: 61 TEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS 120
Query: 328 --PEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGG-GDPPGVNAKKFAEIVAG 384
DLYIS TMPS+EIGTVGGGT + Q+ L ++GV G D PG NA++ A IV G
Sbjct: 121 GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCG 180
Query: 385 AVLAGELSLLAAIAAKHLARAHKMLGR 411
V+AGELSL+AA+AA HL R+H + R
Sbjct: 181 TVMAGELSLMAALAAGHLVRSHMVHNR 207
>pir||A43533 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - mouse
(fragments)
Length = 279
Score = 210 bits (530), Expect = 2e-53
Identities = 113/207 (54%), Positives = 147/207 (70%), Gaps = 4/207 (1%)
Query: 209 EEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTT 268
E+ + ++E FPD++ LA+SGN C DKKP A+N+I GRGKTVV EA++P ++V + LKTT
Sbjct: 56 EKALLKLQEFFPDMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTT 115
Query: 269 PELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVT 327
E + +VN KNLVGSA AGS G+NAH NIV AI++A GQD AQ S+ IT+ E +
Sbjct: 116 TEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEAS 175
Query: 328 --PEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGG-GDPPGVNAKKFAEIVAG 384
DLYIS TMPS+EIGTVGGGT + Q+ L ++GV G D PG NA++ A IV G
Sbjct: 176 GPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCG 235
Query: 385 AVLAGELSLLAAIAAKHLARAHKMLGR 411
V+AGELSL+AA+AA HL R+H + R
Sbjct: 236 TVMAGELSLMAALAAGHLVRSHMVHNR 262
>sp|P29058|HMD2_HEVBR 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2 (HMG-COA
REDUCTASE 2) >gi|100138|pir||S14953
hydroxymethylglutaryl-CoA reductase (NADPH) (EC
1.1.1.34) 2 - Para rubber tree (fragment)
>gi|18837|emb|CAA38468.1| (X54658)
hydroxymethylglutaryl-CoA reductase [Hevea brasiliensis]
Length = 210
Score = 206 bits (519), Expect = 4e-52
Identities = 109/200 (54%), Positives = 144/200 (71%), Gaps = 3/200 (1%)
Query: 215 IEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAE 274
+E +F D+ + +SGN C DKKP AVN+I GRGK+VV EAI+ E+V+K LKT L+ E
Sbjct: 1 LESDFADMDVIGISGNFCSDKKPAAVNWIEGRGKSVVCEAIIKEEVVKKVLKTDVALLVE 60
Query: 275 VNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEG-DL 332
+N KNL GSA AG+ GFNAH GNIV AIF+ATGQD AQ E SH IT+ E +G DL
Sbjct: 61 LNMLKNLAGSAVAGALGGFNAHAGNIVSAIFIATGQDPAQNVESSHCITMMEAVNDGKDL 120
Query: 333 YISITMPSLEIGTVGGGTRVPTQREALSIMGVAGG-GDPPGVNAKKFAEIVAGAVLAGEL 391
+IS+T+PS+E+GTVGGGT++ +Q L+++GV G + PG ++ A IVAG+VLAGEL
Sbjct: 121 HISVTLPSIEVGTVGGGTQLASQSACLNLLGVMGACKESPGSYSRLLATIVAGSVLAGEL 180
Query: 392 SLLAAIAAKHLARAHKMLGR 411
SL++AIAA L ++H R
Sbjct: 181 SLMSAIAAGQLVKSHMKYNR 200
>emb|CAA63971.1| (X94308) HMG-CoA-reductase [Sphaceloma manihoticola]
Length = 277
Score = 188 bits (472), Expect = 1e-46
Identities = 104/266 (39%), Positives = 158/266 (59%), Gaps = 15/266 (5%)
Query: 30 DKRLATEIRRKALERKLG-------ISLKHIGHYSIDPNELIGRNIENMIGVVQIPMGVA 82
DK A +IRR + R + ++ + D + + G EN+IG + +P+GVA
Sbjct: 16 DKTRAVKIRRAMIARTPATTKHSRLLESSNLPYQHFDYDRVFGACCENVIGYMPLPVGVA 75
Query: 83 GPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCP 142
GPL I+GE +++P+ATTEG LVAS +RGC A+ GG VT + D MTR P +
Sbjct: 76 GPLTIDGE----SYFLPMATTEGVLVASTSRGCKAINAGGGAVTVLTADGMTRGPCVGFE 131
Query: 143 NARRAREVAE-WV-KENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMG 200
RA A+ W+ E + + A +R +L+ +K + G +Y+RF+ TG+AMG
Sbjct: 132 TLARAAAAAKLWLDSEEGQKVMKDAFNSTSRFARLQQLKTSLAGTYVYIRFKTTTGEAMG 191
Query: 201 MNMVTIASEEIMKVIEEE--FPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPR 258
MNM++ E+ + V+ +E F D+ +++SGN C DKKP A+N+I GRGK+VVAEAI+P
Sbjct: 192 MNMISKGVEKALDVMAKESGFEDMAIISVSGNFCTDKKPAAINWIDGRGKSVVAEAIIPG 251
Query: 259 EIVEKKLKTTPELIAEVNYFKNLVGS 284
++V LK+ + E+N KNL+GS
Sbjct: 252 DVVRSVLKSDVNALVELNVSKNLIGS 277
>pir||PQ0762 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) (HMGR
18) - wheat (fragment) >gi|545472|gb|AAB29930.1|
3-hydroxy-3-methylglutaryl coenzyme A reductase, HMGR
{clone 18} {EC 1.1.1.34} [Triticum aestivum=wheat,
Yecora rojo, Peptide Partial, 150 aa]
Length = 150
Score = 156 bits (391), Expect = 4e-37
Identities = 81/150 (54%), Positives = 106/150 (70%), Gaps = 2/150 (1%)
Query: 196 GDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAI 255
GDAMGMNM++ + ++ +EE+FPD+ +++SGN C DKK AVN+I GRGK+VV EAI
Sbjct: 1 GDAMGMNMISKGVQHVLDYLEEDFPDMDVVSISGNFCSDKKSAAVNWIEGRGKSVVCEAI 60
Query: 256 VPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQI 314
+ E+VEK L T + + E+N KNL GSA AG+ GFNAH NIV AIF+ATGQD AQ
Sbjct: 61 IREEVVEKVLDTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVSAIFIATGQDPAQN 120
Query: 315 TEGSHGITIAEVTPEG-DLYISITMPSLEI 343
E S IT+ E G DL+IS+TMP +E+
Sbjct: 121 VESSQCITMLEAVNGGRDLHISVTMPPIEV 150
>gb|AAB29931.1| 3-hydroxy-3-methylglutaryl coenzyme A reductase, HMGR {clone 23}
{EC 1.1.1.34} [Triticum aestivum=wheat, Yecora rojo,
Peptide Partial, 150 aa]
Length = 150
Score = 156 bits (390), Expect = 5e-37
Identities = 77/150 (51%), Positives = 108/150 (71%), Gaps = 2/150 (1%)
Query: 196 GDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAI 255
GDAMGMNM++ + ++ ++++FPD+ +++SGN C DKKP AVN+I GRGK+VV EA+
Sbjct: 1 GDAMGMNMISKGVQNVLDYLQDDFPDMDVISISGNFCSDKKPAAVNWIEGRGKSVVCEAV 60
Query: 256 VPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQI 314
+ E+++K LKT + + E+N KNL GSA AG+ GFNAH NIV AIF+ATGQD AQ
Sbjct: 61 IREELIKKVLKTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVTAIFIATGQDPAQN 120
Query: 315 TEGSHGITIAEVTPEG-DLYISITMPSLEI 343
E S I + E +G DL+IS+TMP +E+
Sbjct: 121 VESSQCIAMLEAVNDGKDLHISVTMPPIEV 150
>pir||PQ0763 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) (HMGR
23) - wheat (fragment)
Length = 150
Score = 155 bits (388), Expect = 8e-37
Identities = 77/150 (51%), Positives = 108/150 (71%), Gaps = 2/150 (1%)
Query: 196 GDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAI 255
GDAMGMNM++ + ++ ++++FPD+ +++SGN C DKKP AVN+I GRGK+VV EA+
Sbjct: 1 GDAMGMNMISKGVQNVLDYLQDDFPDMDVISISGNFCSDKKPAAVNWIEGRGKSVVCEAV 60
Query: 256 VPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQI 314
+ E+++K LKT + + E+N KNL GSA AG+ GFNAH NIV AIF+ATGQD AQ
Sbjct: 61 IREELLKKVLKTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVTAIFIATGQDPAQN 120
Query: 315 TEGSHGITIAEVTPEG-DLYISITMPSLEI 343
E S I + E +G DL+IS+TMP +E+
Sbjct: 121 VESSQCIAMLEAVNDGKDLHISVTMPPIEV 150
>pir||PQ0761 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) (HMGR
10) - wheat (fragment)
Length = 150
Score = 148 bits (371), Expect = 8e-35
Identities = 78/150 (52%), Positives = 101/150 (67%), Gaps = 2/150 (1%)
Query: 196 GDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAI 255
GDAMGMNMV+ E ++ I FPD+ +++SGN C DKK AVN+I GRGK+VV EA
Sbjct: 1 GDAMGMNMVSKGVENVLGYIRNNFPDMDVISISGNYCSDKKATAVNWIDGRGKSVVCEAT 60
Query: 256 VPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQI 314
+ +V+ + TT E + E+N KNL GSA AG+ GFNAH NI A+F+ATGQD AQ
Sbjct: 61 IKGRVVQSVIDTTVEKLVELNIIKNLAGSAVAGALGGFNAHASNIATALFIATGQDPAQN 120
Query: 315 TEGSHGITIAEVTPEG-DLYISITMPSLEI 343
E S IT+ E EG DL+IS+TMP +E+
Sbjct: 121 VESSQCITMLEAVNEGKDLHISVTMPPIEV 150
>gb|AAB29929.1| 3-hydroxy-3-methylglutaryl coenzyme A reductase, HMGR {clone 10}
{EC 1.1.1.34} [Triticum aestivum=wheat, Yecora rojo,
Peptide Partial, 150 aa]
Length = 150
Score = 148 bits (371), Expect = 8e-35
Identities = 78/150 (52%), Positives = 101/150 (67%), Gaps = 2/150 (1%)
Query: 196 GDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAI 255
GDAMGMNMV+ E ++ + FPD+ +++SGN C DKK AVN+I GRGK+VV EA
Sbjct: 1 GDAMGMNMVSKGVENVLGYLRNNFPDMDVISISGNYCSDKKATAVNWIDGRGKSVVCEAT 60
Query: 256 VPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAIFLATGQDEAQI 314
+ +V+ L TT E + E+N KNL GSA AG+ GFNAH NI A+F+ATGQD AQ
Sbjct: 61 IKGRVVQSVLDTTVEKLVELNIIKNLAGSAVAGALGGFNAHASNIATALFIATGQDPAQN 120
Query: 315 TEGSHGITIAEVTPEG-DLYISITMPSLEI 343
E S IT+ E EG DL+IS+TMP +E+
Sbjct: 121 VESSQCITMLEAVNEGKDLHISVTMPPIEV 150
>emb|CAA52787.1| (X74783) 3-hydroxy-3-methyl glutaryl coenzyme A reductase
[Lithospermum erythrorhizon]
Length = 148
Score = 141 bits (352), Expect = 1e-32
Identities = 70/148 (47%), Positives = 101/148 (67%), Gaps = 1/148 (0%)
Query: 100 LATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLN 159
+ATTEG LVAS NRGC A+ +GG + +L D MTRAP++R A+RA E+ ++++ LN
Sbjct: 1 MATTEGCLVASTNRGCKAIYASGGATSVVLRDAMTRAPVVRFGTAKRAAELKFFLEDPLN 60
Query: 160 YLQ-EKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEE 218
+ A + +R G+L+ +K I G NLY RF TGDAMGMNMV+ +++ ++ ++ E
Sbjct: 61 FETIAAAFNQSSRFGRLQSIKCAIAGKNLYTRFSCSTGDAMGMNMVSKGTQQSLEFLQNE 120
Query: 219 FPDVRYLALSGNLCVDKKPNAVNFILGR 246
FPD+ + +SGN C DKKP AVN+I GR
Sbjct: 121 FPDMDVIGISGNYCSDKKPAAVNWIEGR 148
>gb|AAD09278.1| (U97683) 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Glycine
max]
Length = 121
Score = 132 bits (328), Expect = 9e-30
Identities = 68/120 (56%), Positives = 88/120 (72%), Gaps = 2/120 (1%)
Query: 245 GRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSY-GFNAHFGNIVGAI 303
GRGK+VV EAI+ E+V+K LKT + E+N KNL GSA AG+ GFNAH NIV AI
Sbjct: 2 GRGKSVVCEAIIKEEVVQKVLKTNVSALVELNMLKNLAGSAVAGALGGFNAHASNIVSAI 61
Query: 304 FLATGQDEAQITEGSHGITIAEVTPEG-DLYISITMPSLEIGTVGGGTRVPTQREALSIM 362
F+ATGQD AQ E SH IT+ E +G DL+IS+TMPS+E+GTVGGGT++ +Q L+++
Sbjct: 62 FIATGQDPAQNVESSHCITMMEAINDGRDLHISVTMPSIEVGTVGGGTQLASQSACLNLL 121
>gb|AAB04043.1| (L40938) HMGR CoA reductase [Lycopersicon esculentum]
Length = 343
Score = 117 bits (291), Expect = 2e-25
Identities = 64/154 (41%), Positives = 98/154 (63%), Gaps = 5/154 (3%)
Query: 7 EDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGR 66
E+II+ V G+ + +E + GD A IR++AL+R G SL+ + D ++G+
Sbjct: 186 EEIIQSVVQGKTPSYSLESKL-GDCMRAASIRKEALQRITGKSLEGLPLEGFDYESILGQ 244
Query: 67 NIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVT 126
E +G VQIP+G+AGPL ++G E+ +P+ATTEG LVAS NRGC A+ +GG +
Sbjct: 245 CCEMPVGYVQIPVGIAGPLLLDGR----EYSVPMATTEGCLVASTNRGCKAIFVSGGANS 300
Query: 127 TILDDKMTRAPLIRCPNARRAREVAEWVKENLNY 160
+L D MTRAP++R A+RA E+ +V++ LN+
Sbjct: 301 ILLRDGMTRAPVVRFTTAKRAAELKFFVEDPLNF 334
>pir||T10099 probable hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34)
- cucumber (fragment) >gi|1199472|dbj|BAA09705.1|
(D63389) 3-hydroxy-3-methylglutaryl CoA reductase
[Cucumis sativus]
Length = 102
Score = 99.8 bits (245), Expect = 5e-20
Identities = 45/89 (50%), Positives = 64/89 (71%)
Query: 168 KVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLAL 227
K +R +L+++K I G NLY RF TGDAMGMNMV+ + ++ ++E+FPD+ + +
Sbjct: 9 KSSRFARLQNIKCAIAGKNLYTRFSCSTGDAMGMNMVSKGVQNVLDFLQEDFPDMDVIGI 68
Query: 228 SGNLCVDKKPNAVNFILGRGKTVVAEAIV 256
SGN C DKKP AVN+I GRGK+VV EA++
Sbjct: 69 SGNFCSDKKPAAVNWIEGRGKSVVCEAVI 97
>pir||S42214 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - Mucor
mucedo (fragment)
Length = 105
Score = 94.4 bits (231), Expect = 2e-18
Identities = 44/105 (41%), Positives = 61/105 (57%)
Query: 99 PLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENL 158
P+ATTEG LVAS RGC A+ GG T ++ D MTR P + PN RA + W+++
Sbjct: 1 PMATTEGCLVASTARGCKAINAGGGATTIVIADGMTRGPCVEFPNITRAADCKRWIEQEG 60
Query: 159 NYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNM 203
+ A +R ++R +K + G +Y+RF TGDAMGMNM
Sbjct: 61 EAIVTGAFNSTSRFARVRKLKVALAGRLVYIRFSTTTGDAMGMNM 105
>pir||S42215 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) -
Parasitella parasitica (fragment)
Length = 105
Score = 94.0 bits (230), Expect = 3e-18
Identities = 44/105 (41%), Positives = 62/105 (58%)
Query: 99 PLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENL 158
P+ATTEG LVAS RGC A+ GG T ++ D MTR P + PN RA + W+++
Sbjct: 1 PMATTEGCLVASAARGCKAINAGGGATTIVIADGMTRGPCVEFPNILRAADCKRWIEQEG 60
Query: 159 NYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNM 203
+ +A +R ++R +K + G +Y+RF TGDAMGMNM
Sbjct: 61 EKVVTEAFNSTSRFARVRKMKVALAGCLMYIRFSTTTGDAMGMNM 105
>pir||S42212 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - pin
mould (Absidia glauca) (fragment)
Length = 105
Score = 93.2 bits (228), Expect = 5e-18
Identities = 45/105 (42%), Positives = 60/105 (56%)
Query: 99 PLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENL 158
P+ATTEG LVAS RGC A+ GG T + D MTR P + P RA E W+++
Sbjct: 1 PMATTEGCLVASAARGCKAIDAGGGAWTVVTADGMTRGPCVEFPTVLRAAECKRWIEQEG 60
Query: 159 NYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNM 203
N + A +R +LR +K + G +++RF TGDAMGMNM
Sbjct: 61 NTILTDAFNSTSRFARLRKLKVALAGKLVFIRFSTTTGDAMGMNM 105
>gi|11499325 3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA)
[Archaeoglobus fulgidus]
>gi|3929353|sp|O28538|HMDH_ARCFU
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA
REDUCTASE) >gi|7482877|pir||G69466
3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA)
homolog - Archaeoglobus fulgidus
>gi|2648815|gb|AAB89513.1| (AE000983)
3-hydroxy-3-methylglutaryl-coenzyme A reductase (mvaA)
[Archaeoglobus fulgidus]
Length = 436
Score = 93.2 bits (228), Expect = 5e-18
Identities = 100/402 (24%), Positives = 168/402 (40%), Gaps = 51/402 (12%)
Query: 27 VNGDKRLATEIRRKALERKLGISLKHIGHYSID--PNELIGRNIENMIGVVQIPMGVAGP 84
+ G +L+ E R K + G+S + + P ++ R IEN+IG ++P+G+A
Sbjct: 24 IPGFYKLSVEERLKKVAEFAGLSDEEVKAVLSQGLPLDVADRMIENVIGTFELPLGIATN 83
Query: 85 LKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILDDKM---TRAPLIRC 141
I+G+ ++ IP+A E ++VA+ + E+GG T M + +
Sbjct: 84 FLIDGK----DYLIPMAIEEPSVVAAASNAARMARESGGFTTDYTGSLMIGQIQVTKLLN 139
Query: 142 PNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVK----PFIVGNNLYLRFEFETGD 197
PNA + EV E + E V G +D++ I+G L + + D
Sbjct: 140 PNAAKF-EVLRQKDEIIERANECDPMLVNLGGGCKDIEARVIDTIMGKMLIVHLIVDVKD 198
Query: 198 AMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVP 257
AMG N V E++ IE YL + NL + L R K V + ++
Sbjct: 199 AMGANAVNTMCEKVAPFIERITGGKVYLRIISNLAA--------YRLARAKAVFDKDVIG 250
Query: 258 REIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIFLATGQDEAQITEG 317
E E++ + + N N + A+ +ATG D I G
Sbjct: 251 GE----------EVVEGIMLAYAFAAADPFRCATHNKGIMNGISALMIATGNDFRAIEAG 300
Query: 318 SHG---------ITIAEVTPEGDLYISITMPSLEIGTVGGGTRV-PTQREALSIMGVAGG 367
+H +T EV +G+L +I +P + +G +GG T+V P + +L I+GV
Sbjct: 301 AHSYAAIGGYKPLTTYEVDRKGNLVGTIEIP-MAVGVIGGATKVNPLAKISLKILGVN-- 357
Query: 368 GDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKML 409
A++ A + A LA + L A+A + + R H L
Sbjct: 358 ------TAEELARVAAALGLAQNFAALRALATEGIQRGHMEL 393
>pir||S42213 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) -
Blakeslea trispora (fragment)
Length = 105
Score = 91.7 bits (224), Expect = 1e-17
Identities = 43/105 (40%), Positives = 61/105 (57%)
Query: 99 PLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENL 158
P+ATTEG LVAS RGC A+ GG T ++ D MTR P + P RA + W+++
Sbjct: 1 PMATTEGCLVASTARGCKAINAGGGANTIVVADGMTRGPCVEFPTITRAADCKRWIEQEG 60
Query: 159 NYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNM 203
+ +A +R ++R +K + G +Y+RF TGDAMGMNM
Sbjct: 61 EAIVTEAFNSTSRFARVRKLKVALAGRLVYIRFSTTTGDAMGMNM 105
>pir||S17343 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) - fungus
(Gibberella fujikuroi) (fragment)
>gi|2740|emb|CAA41261.1| (X58370)
hydroxymethylglutaryl-CoA reductase (NADPH) [Gibberella
fujikuroi]
Length = 106
Score = 90.1 bits (220), Expect = 4e-17
Identities = 44/106 (41%), Positives = 60/106 (56%), Gaps = 1/106 (0%)
Query: 99 PLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENL 158
P+ATTEG LVAS +RGC A+ GG +T + D MTR P + RA W+
Sbjct: 1 PMATTEGVLVASASRGCKAINSGGGAITVLTADGMTRGPCVAFETLERAGAAKLWLDSEA 60
Query: 159 NY-LQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNM 203
+ +KA + +L+ +K + G NLY+RF+ TGDAMGMNM
Sbjct: 61 GQDMMKKAFNSTSSFARLQSMKTALAGTNLYIRFKTTTGDAMGMNM 106
>sp|Q12649|HMDH_PHYBL 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA REDUCTASE)
>gi|100999|pir||S17345 hydroxymethylglutaryl-CoA
reductase (NADPH) (EC 1.1.1.34) - Phycomyces
blakesleeanus (fragment)
Length = 105
Score = 89.7 bits (219), Expect = 5e-17
Identities = 44/105 (41%), Positives = 59/105 (55%)
Query: 99 PLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENL 158
P+ATTEG LVAS RGC A+ GG T ++ D MTR P + P RA W++
Sbjct: 1 PMATTEGCLVASTARGCKAINAGGGASTIVIADGMTRGPCVEFPTILRAAACKLWIENEG 60
Query: 159 NYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNM 203
N + A +R +LR +K + G +++RF TGDAMGMNM
Sbjct: 61 NDIVTNAFNSTSRFARLRKLKIALAGKLVFIRFSTTTGDAMGMNM 105
>gb|AAG02444.1|AF290094_2 (AF290094) acetyl-CoA acetyltransferase/HMG-CoA reductase
[Enterococcus faecium]
Length = 813
Score = 81.1 bits (197), Expect = 2e-14
Identities = 89/372 (23%), Positives = 164/372 (43%), Gaps = 66/372 (17%)
Query: 62 ELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRG------- 114
EL IEN + V+IPMG+A +ING+ + +IP+AT E +++A+ + G
Sbjct: 434 ELSDHMIENQVSEVEIPMGIAQNFQINGK----KKWIPMATEEPSVIAAASNGAKICGNI 489
Query: 115 CSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGK 174
C+ + +L K +I N R+ +E + E + V R G
Sbjct: 490 CAETPQRLMRGQIVLSGKSEYQAVINAVNHRK--------EELILCANESYPSIVKRGGG 541
Query: 175 LRDV--KPFIVGNNLYLRFEF--ETGDAMGMNMVTIASEEIMKVIEEEFPDVRYL-ALSG 229
++D+ + F+ + YL +F + DAMG NM+ E + + E FP+ L ++
Sbjct: 542 VQDISTREFMGSFHAYLSIDFLVDVKDAMGANMINSILESVANKLREWFPEEEILFSILS 601
Query: 230 NLCVDKKPNAVNFI----LGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSA 285
N + +A I LGR K + E + KK++ E A+++ ++
Sbjct: 602 NFATESLASACCEIPFERLGRNKEI-------GEQIAKKIQQAGE-YAKLDPYR------ 647
Query: 286 QAGSYGFNAHFGNIVGAIFLATGQDEAQITEGSH----------GITIAEVTPEGDLYIS 335
+ N N + A+ ATG D ++ H G+T ++ +GD +
Sbjct: 648 ---AATHNKGIMNGIEAVVAATGNDTRAVSASIHAYAARNGLYQGLTDWQI--KGDKLVG 702
Query: 336 ITMPSLEIGTVGGGTRV-PTQREALSIMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLL 394
L + TVGG + + P + +L+++ + +AK+ A+++A LA L+ L
Sbjct: 703 KLTVPLAVATVGGASNILPKAKASLAMLDID--------SAKELAQVIAAVGLAQNLAAL 754
Query: 395 AAIAAKHLARAH 406
A+ + + + H
Sbjct: 755 RALVTEGIQKGH 766
>pir||T10269 hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) -
sea-island cotton (fragment) >gi|1839561|gb|AAB47161.1|
(S82272) 3-hydroxy-3-methylglutaryl coenzyme A
reductase; 3-hydroxy-3-methylglutaryl CoA reductase;
HMGR [Gossypium barbadense]
Length = 73
Score = 80.8 bits (196), Expect = 3e-14
Identities = 36/70 (51%), Positives = 52/70 (73%)
Query: 215 IEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAE 274
++ +FPD+ + +SGN C DKKP AVN+I GRGK+VV EAI+ ++++K LKT+ E + E
Sbjct: 4 LQTDFPDMDVIGISGNFCSDKKPAAVNWIEGRGKSVVCEAIIKGDVIKKVLKTSVESLVE 63
Query: 275 VNYFKNLVGS 284
+N KNL GS
Sbjct: 64 LNMLKNLAGS 73
>emb|CAB53533.1| (AJ237676) 3-hydroxy-3-methylglutaryl CoA reductase [Bos taurus]
Length = 80
Score = 79.6 bits (193), Expect = 6e-14
Identities = 42/78 (53%), Positives = 53/78 (67%), Gaps = 2/78 (2%)
Query: 291 GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGG 348
G+NAH NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVGG
Sbjct: 3 GYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGG 62
Query: 349 GTRVPTQREALSIMGVAG 366
GT + Q+ L ++GV G
Sbjct: 63 GTNLLPQQACLQMLGVQG 80
>gb|AAD14314.1|S79678_1 (S79678) 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA
reductase [Sus scrofa]
Length = 79
Score = 72.2 bits (174), Expect = 1e-11
Identities = 39/76 (51%), Positives = 50/76 (65%), Gaps = 2/76 (2%)
Query: 291 GFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVT--PEGDLYISITMPSLEIGTVGG 348
G+NAH NIV AI++A GQD AQ S+ IT+ E + DLYIS TMPS+EIGTVG
Sbjct: 4 GYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGR 63
Query: 349 GTRVPTQREALSIMGV 364
G + Q+ L ++GV
Sbjct: 64 GASLLPQQACLQMLGV 79
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.317 0.137 0.383
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 149443878
Number of Sequences: 2977
Number of extensions: 6463372
Number of successful extensions: 16871
Number of sequences better than 1.0e-10: 110
Number of HSP's better than 0.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 16317
Number of HSP's gapped (non-prelim): 113
length of query: 411
length of database: 189,106,746
effective HSP length: 59
effective length of query: 352
effective length of database: 153,796,013
effective search space: 54136196576
effective search space used: 54136196576
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 166 (69.1 bits)