BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2187 257359 256922 -146 !not a gene!
(146 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75215 methylmalonyl-coa mutase, chain alpha, c-terminus (m... 229 1e-59
pir||D71452 probable methylmalony-CoA mutase - Pyrococcus horiko... 217 4e-56
gi|11499801 methylmalonyl-CoA mutase, subunit alpha, C-terminus ... 159 1e-38
gi|11500023 Methylmalonyl-CoA mutase, C-terminal domain/subunit ... 131 3e-30
gb|AAK42430.1| Methylmalonyl-CoA mutase, alpha-subunit, chain B ... 127 5e-29
emb|CAB71846.1| (AL138667) probable isobutyryl-CoA mutase, small... 124 4e-28
emb|CAB59633.1| (AJ246005) isobutyryl-CoA mutase, small subunit ... 121 3e-27
pir||B72550 probable methylmalonyl-CoA mutase alpha-subunit APE1... 120 6e-27
pir||C75325 methylmalonyl-CoA mutase, alpha subunit, chain B - D... 120 6e-27
emb|CAB92663.1| (AL356832) isobutiryl CoA mutase, small subunit ... 120 1e-26
gb|AAG19166.1| (AE005014) methylmalonyl-CoA mutase; McmA2 [Halob... 116 1e-25
emb|CAC11605.1| (AL445064) probable methylmalonyl-CoA mutase, al... 110 7e-24
pir||T35959 methylmalonyl-CoA mutase, coenzyme B12-dependent - S... 99 2e-20
gb|AAC45598.1| (AF008569) coenzyme B12-dependent mutase [Strepto... 93 2e-18
sp|Q23381|MUTA_CAEEL PROBABLE METHYLMALONYL-COA MUTASE, MITOCHON... 89 2e-17
sp|P27253|SBM_ECOLI SBM PROTEIN >gi|96094|pir||S22099 sbm protei... 88 4e-17
pir||D65076 sbm protein - Escherichia coli >gi|882446|gb|AAA6908... 88 4e-17
gi|4557767 methylmalonyl Coenzyme A mutase precursor [Homo sapie... 88 6e-17
pir||S40622 methylmalonyl CoA mutase precursor - human 88 6e-17
gb|AAA99226.1| (M37510) methylmalonyl-CoA mutase [Homo sapiens] 88 6e-17
dbj|BAB06674.1| (AP001517) methylmalonyl-CoA mutase alpha subuni... 88 6e-17
emb|CAC17595.1| (AJ300476) methylmalonyl-CoA mutase [Bos taurus] 88 6e-17
pir||S13043 methylmalonyl-CoA mutase (EC 5.4.99.2) - mouse 87 1e-16
gb|AAB31158.1| methylmalonyl CoA mutase, MCM {EC 5.4.99.2} [huma... 87 1e-16
sp|O86028|MUTB_RHIME METHYLMALONYL-COA MUTASE (MCM) >gi|3549312|... 87 1e-16
sp|P11653|MUTB_PROFR METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM... 85 4e-16
sp|Q59677|MUTA_PORGI METHYLMALONYL-COA MUTASE BETA-SUBUNIT (MCB-... 85 4e-16
pdb|6REQ|A Chain A, Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Co... 85 4e-16
pdb|5REQ|A Chain A, Methylmalonyl-Coa Mutase, Y89f Mutant, Subst... 85 4e-16
pdb|1E1C|A Chain A, Methylmalonyl-Coa Mutase H244a Mutant >gi|85... 85 4e-16
sp|Q05065|MUTB_STRCM METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM... 85 5e-16
sp|Q49115|MEAA_METEX MEAA PROTEIN >gi|1098584|gb|AAC44087.1| (U2... 83 1e-15
gi|6678970 methylmalonyl-Coenzyme A mutase [Mus musculus] >gi|12... 82 2e-15
pir||F75440 methylmalonyl-CoA mutase, beta subunit - Deinococcus... 81 7e-15
sp|P71774|MUTB_MYCTU PROBABLE METHYLMALONYL-COA MUTASE LARGE SUB... 80 9e-15
>pir||G75215 methylmalonyl-coa mutase, chain alpha, c-terminus (mcma2) PAB2187 -
Pyrococcus abyssi (strain Orsay)
>gi|5457683|emb|CAB49174.1| (AJ248283) methylmalonyl-CoA
mutase, subunit alpha, C-terminus (mcmA2) [Pyrococcus
abyssi]
Length = 146
Score = 229 bits (578), Expect = 1e-59
Identities = 120/146 (82%), Positives = 120/146 (82%)
Query: 1 MPKVVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXX 60
MPKVVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTP
Sbjct: 1 MPKVVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVEAVIEED 60
Query: 61 XXXLGISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVF 120
LGISILSGAHMV GVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVF
Sbjct: 61 VDVLGISILSGAHMVLIPKILKLLEEKGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVF 120
Query: 121 GPGTPLKEIIEFIDNNVGKLKKFRNS 146
GPGTPLKEIIEFIDNNVGKLKKFRNS
Sbjct: 121 GPGTPLKEIIEFIDNNVGKLKKFRNS 146
>pir||D71452 probable methylmalony-CoA mutase - Pyrococcus horikoshii
>gi|3256664|dbj|BAA29347.1| (AP000001) 147aa long
hypothetical methylmalony-CoA mutase [Pyrococcus
horikoshii]
Length = 147
Score = 217 bits (548), Expect = 4e-56
Identities = 112/146 (76%), Positives = 117/146 (79%)
Query: 1 MPKVVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXX 60
M K+VERSKVRVL+AKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTP
Sbjct: 1 MRKMVERSKVRVLVAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVEAVIEED 60
Query: 61 XXXLGISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVF 120
LGISILSGAHMV G+KVNEDVLV+AGGIIPPDDAEELKKMGVAEVF
Sbjct: 61 VDVLGISILSGAHMVLIPKILKLLEEKGIKVNEDVLVVAGGIIPPDDAEELKKMGVAEVF 120
Query: 121 GPGTPLKEIIEFIDNNVGKLKKFRNS 146
GPGTPL+EIIEFID NVGKLKKFR S
Sbjct: 121 GPGTPLREIIEFIDKNVGKLKKFRES 146
>gi|11499801 methylmalonyl-CoA mutase, subunit alpha, C-terminus (mcmA2)
[Archaeoglobus fulgidus] >gi|7483869|pir||C69527
methylmalonyl-CoA mutase, subunit alpha, C-terminus
(mcmA2) homolog - Archaeoglobus fulgidus
>gi|2648305|gb|AAB89034.1| (AE000952) methylmalonyl-CoA
mutase, subunit alpha, C-terminus (mcmA2) [Archaeoglobus
fulgidus]
Length = 144
Score = 159 bits (398), Expect = 1e-38
Identities = 79/134 (58%), Positives = 96/134 (70%)
Query: 9 KVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISI 68
K+RV++AKPGLDGHDRGAKVVARALRDAG+EVIYTGIR+TP +G+SI
Sbjct: 11 KIRVIVAKPGLDGHDRGAKVVARALRDAGFEVIYTGIRRTPEEIAETALQEDADVVGLSI 70
Query: 69 LSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKE 128
LSGAH+ G++ N DVLVI GGI+P +D +LK+MGVA+VFGPGTPL E
Sbjct: 71 LSGAHLELTPMVIEELRKRGLEPNRDVLVIVGGIVPEEDVPKLKEMGVAKVFGPGTPLNE 130
Query: 129 IIEFIDNNVGKLKK 142
II+FI V KLK+
Sbjct: 131 IIDFIRAEVPKLKR 144
>gi|11500023 Methylmalonyl-CoA mutase, C-terminal domain/subunit [Archaeoglobus
fulgidus]
Length = 138
Score = 131 bits (327), Expect = 3e-30
Identities = 68/134 (50%), Positives = 87/134 (64%), Gaps = 1/134 (0%)
Query: 9 KVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISI 68
K+RVL+AK GLDGHDRGAKV+AR LRDAG+EVIYTG+ +TP +GIS+
Sbjct: 4 KIRVLVAKVGLDGHDRGAKVLARFLRDAGFEVIYTGLHRTPQEVAMAAVDEDVDVVGISL 63
Query: 69 LSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKE 128
SGAH+ G +E +L++ GG+IP DD ELKKMGV EVF PGTP+ E
Sbjct: 64 HSGAHLALVPKVINYIREYGGNPDE-MLILVGGVIPTDDIVELKKMGVDEVFIPGTPISE 122
Query: 129 IIEFIDNNVGKLKK 142
I+EFI + + +K
Sbjct: 123 IVEFIKTKLPEKRK 136
>gb|AAK42430.1| Methylmalonyl-CoA mutase, alpha-subunit, chain B (mcmA2)
[Sulfolobus solfataricus]
Length = 141
Score = 127 bits (317), Expect = 5e-29
Identities = 65/128 (50%), Positives = 86/128 (66%), Gaps = 3/128 (2%)
Query: 4 VVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXX 63
++ +++V++AK GLDGHDRGAKVVARAL+DAG EV+YTG+RQTP
Sbjct: 2 MITTKRIKVIVAKLGLDGHDRGAKVVARALKDAGMEVVYTGLRQTPEQIVRAALQEDADV 61
Query: 64 LGISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPG 123
+GISILSGAH+ G+ DV +I GG+IPP+D ++LK+MGV EVF PG
Sbjct: 62 IGISILSGAHLELIPKVVEIMKQNGL---NDVGLIVGGVIPPEDIKKLKEMGVDEVFLPG 118
Query: 124 TPLKEIIE 131
+ LKEI+E
Sbjct: 119 SSLKEIVE 126
>emb|CAB71846.1| (AL138667) probable isobutyryl-CoA mutase, small subunit.
[Streptomyces coelicolor A3(2)]
Length = 159
Score = 124 bits (309), Expect = 4e-28
Identities = 62/129 (48%), Positives = 83/129 (64%), Gaps = 3/129 (2%)
Query: 10 VRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISIL 69
+RV++AKPGLDGHDRGAKVVARALRDAG EVIYTG+ QTP +G+S+L
Sbjct: 6 MRVVVAKPGLDGHDRGAKVVARALRDAGVEVIYTGLHQTPAQIVATAIQEDADGIGLSVL 65
Query: 70 SGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKEI 129
SGAHM ++ +++V GGIIP DDA L + GVA +F PGT + +
Sbjct: 66 SGAHMTAFTEVMKLIQ---LEEATNIIVFGGGIIPDDDAANLLEGGVAALFTPGTSMATV 122
Query: 130 IEFIDNNVG 138
++++ N+VG
Sbjct: 123 VDWVTNHVG 131
>emb|CAB59633.1| (AJ246005) isobutyryl-CoA mutase, small subunit [Streptomyces
cinnamonensis]
Length = 136
Score = 121 bits (301), Expect = 3e-27
Identities = 64/133 (48%), Positives = 77/133 (57%), Gaps = 3/133 (2%)
Query: 5 VERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXL 64
V +RV++AKPGLDGHDRGAKV+ARALRDAG EVIYTG+ QTP +
Sbjct: 3 VAAGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQVVDTAIQEDADAI 62
Query: 65 GISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGT 124
G+SILSGAH ED+ V GGIIP D LK+ GVAE+F PG
Sbjct: 63 GLSILSGAHNTLFARVLELLKERDA---EDIKVFGGGIIPEADIAPLKEKGVAEIFTPGA 119
Query: 125 PLKEIIEFIDNNV 137
I+E++ NV
Sbjct: 120 TTTSIVEWVRGNV 132
>pir||B72550 probable methylmalonyl-CoA mutase alpha-subunit APE1686 - Aeropyrum
pernix (strain K1) >gi|5105374|dbj|BAA80687.1|
(AP000062) 163aa long hypothetical methylmalonyl-CoA
mutase alpha-subunit [Aeropyrum pernix]
Length = 163
Score = 120 bits (299), Expect = 6e-27
Identities = 62/125 (49%), Positives = 79/125 (62%), Gaps = 3/125 (2%)
Query: 7 RSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGI 66
R + +VL+AK GLDGHDRGAKVVARALRDAG+EV+YTG+RQTP +G+
Sbjct: 18 RRRYKVLVAKMGLDGHDRGAKVVARALRDAGFEVVYTGLRQTPEQVAMAAVQEDVDVIGV 77
Query: 67 SILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPL 126
SIL+GAH+ G +D+ V+ GG IP D E L+ +G+ E+F PGT L
Sbjct: 78 SILNGAHLHLMKRLMAKLRELGA---DDIPVVLGGTIPIPDLEPLRSLGIREIFLPGTSL 134
Query: 127 KEIIE 131
EIIE
Sbjct: 135 GEIIE 139
>pir||C75325 methylmalonyl-CoA mutase, alpha subunit, chain B - Deinococcus
radiodurans (strain R1)
>gi|6459815|gb|AAF11575.1|AE002039_5 (AE002039)
methylmalonyl-CoA mutase, alpha subunit, chain B
[Deinococcus radiodurans]
Length = 142
Score = 120 bits (299), Expect = 6e-27
Identities = 62/125 (49%), Positives = 78/125 (61%), Gaps = 3/125 (2%)
Query: 9 KVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISI 68
++RVLIAKPG+DGHDRGAKVVARALRDAG EVIYTG+RQT +G+S+
Sbjct: 7 RIRVLIAKPGMDGHDRGAKVVARALRDAGMEVIYTGLRQTADMIVNAAVQEDVDAIGLSV 66
Query: 69 LSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKE 128
LSGAHM G D++V GGIIP D +LK+MGV +VF PGT ++
Sbjct: 67 LSGAHMHYFKEVTELLREQGA---GDIIVFGGGIIPDQDLPKLKEMGVGQVFTPGTSTED 123
Query: 129 IIEFI 133
++
Sbjct: 124 AAAYL 128
>emb|CAB92663.1| (AL356832) isobutiryl CoA mutase, small subunit [Streptomyces
coelicolor A3(2)]
Length = 138
Score = 120 bits (297), Expect = 1e-26
Identities = 63/133 (47%), Positives = 77/133 (57%), Gaps = 3/133 (2%)
Query: 5 VERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXL 64
V +RV++AKPGLDGHDRGAKV+ARALRDAG EVIYTG+ QTP +
Sbjct: 3 VAAGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDADAI 62
Query: 65 GISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGT 124
G+SILSGAH D+LV GGIIP D LK+ GVAE+F PG
Sbjct: 63 GLSILSGAHNTLFAAVIELLRERDA---ADILVFGGGIIPEADIAPLKEKGVAEIFTPGA 119
Query: 125 PLKEIIEFIDNNV 137
I++++ NV
Sbjct: 120 TTASIVDWVRANV 132
>gb|AAG19166.1| (AE005014) methylmalonyl-CoA mutase; McmA2 [Halobacterium sp.
NRC-1]
Length = 138
Score = 116 bits (288), Expect = 1e-25
Identities = 61/127 (48%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 10 VRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISIL 69
VR L+AK GLDGHDRGA V+ RA RDAG+EVIY+G+ + P LGISIL
Sbjct: 9 VRCLVAKVGLDGHDRGAHVITRAFRDAGFEVIYSGLHKAPDEIVQAAVQEDVDVLGISIL 68
Query: 70 SGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKEI 129
SGAH ED LVI GGIIP +D +L+ GV +FGPGTP+ +
Sbjct: 69 SGAHNTLVPKIIEGLAEYDAA--EDTLVIVGGIIPDEDRADLEAAGVDAIFGPGTPMADT 126
Query: 130 IEFIDNN 136
I FI++N
Sbjct: 127 ISFIESN 133
>emb|CAC11605.1| (AL445064) probable methylmalonyl-CoA mutase, alpha subunit,
C-terminus [Thermoplasma acidophilum]
Length = 146
Score = 110 bits (273), Expect = 7e-24
Identities = 56/124 (45%), Positives = 75/124 (60%), Gaps = 3/124 (2%)
Query: 10 VRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISIL 69
++VL+AKP +DGHDRG V+ARALRDAG +VIY G+ TP +G+S+L
Sbjct: 13 IKVLLAKPAIDGHDRGIFVLARALRDAGMDVIYAGLLPTPEQVVDIAISEDVDVIGLSLL 72
Query: 70 SGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKEI 129
+GAHM GV +D+ V+ GGIIP DD +L+ +GV +GPGTPL I
Sbjct: 73 NGAHMTAFKKVVDLLKERGV---DDIAVVGGGIIPDDDKPKLEAIGVTGNYGPGTPLSTI 129
Query: 130 IEFI 133
I+ I
Sbjct: 130 IDHI 133
>pir||T35959 methylmalonyl-CoA mutase, coenzyme B12-dependent - Streptomyces
coelicolor >gi|4154067|emb|CAA22720.1| (AL035161)
coenzyme B12-dependent mutase [Streptomyces coelicolor
A3(2)]
Length = 675
Score = 99.1 bits (243), Expect = 2e-20
Identities = 55/120 (45%), Positives = 67/120 (55%), Gaps = 3/120 (2%)
Query: 3 KVVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXX 62
K +E K+R L+ KPGLDGH GA+ +A RDAG+EV+Y GIR TP
Sbjct: 530 KEMEVGKLRFLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTPEQIVDAALAEDVH 589
Query: 63 XLGISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGP 122
+G+SILSG+H G D+ VIAGGIIP DAEEL+ GVA VF P
Sbjct: 590 AVGLSILSGSHAQLVPDVLERLRVAGA---TDIPVIAGGIIPNGDAEELRAAGVAAVFTP 646
>gb|AAC45598.1| (AF008569) coenzyme B12-dependent mutase [Streptomyces collinus]
Length = 674
Score = 92.8 bits (227), Expect = 2e-18
Identities = 53/114 (46%), Positives = 65/114 (56%), Gaps = 4/114 (3%)
Query: 9 KVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISI 68
K+R L+ KPGLDGH GA+ +A RDAG+EV+Y GIR TP +G+SI
Sbjct: 536 KLRFLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTP-EQIVDAALAEDVTVGLSI 594
Query: 69 LSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGP 122
LSG+H G D+ VIAGGIIP DAE+LK+ GVA VF P
Sbjct: 595 LSGSHARLVPDVLQRLRVAGA---TDIPVIAGGIIPNGDAEQLKEAGVAAVFTP 645
>sp|Q23381|MUTA_CAEEL PROBABLE METHYLMALONYL-COA MUTASE, MITOCHONDRIAL PRECURSOR (MCM)
>gi|7510897|pir||T27674 hypothetical protein ZK1058.1 -
Caenorhabditis elegans >gi|3881495|emb|CAA84676.1|
(Z35604) contains similarity to Pfam domain: PF01642
(Methylmalonyl-CoA mutase), Score=1148.4, E-value=0,
N=1~cDNA EST EMBL:M89407 comes from this gene~cDNA EST
CEMSB12F comes from this gene~cDNA EST yk20d12.3 comes
from this gene~cDNA EST yk23a1.3 com>
Length = 744
Score = 89.3 bits (218), Expect = 2e-17
Identities = 55/150 (36%), Positives = 76/150 (50%), Gaps = 16/150 (10%)
Query: 1 MPKVVERSKV---------RVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXX 51
M +V+ER K R+++AK G DGHDRGAKV+A D G++V + QTP
Sbjct: 588 MSQVLERVKSFADRDGRQPRIMVAKMGQDGHDRGAKVIATGFADLGFDVDVGPLFQTPLE 647
Query: 52 XXXXXXXXXXXXLGISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEEL 111
+G S L+ H+ G D+LV+AGG+IPP D +EL
Sbjct: 648 AAQQAVDADVHVIGASSLAAGHLTLIPQLIGELKKLG---RPDILVVAGGVIPPQDYKEL 704
Query: 112 KKMGVAEVFGPGTPL----KEIIEFIDNNV 137
GVA VFGPGT L +I+E ++ N+
Sbjct: 705 YDAGVALVFGPGTRLPACANQILEKLEANL 734
>sp|P27253|SBM_ECOLI SBM PROTEIN >gi|96094|pir||S22099 sbm protein - Escherichia coli
>gi|42945|emb|CAA47311.1| (X66836) sbm orf [Escherichia
coli]
Length = 714
Score = 88.2 bits (215), Expect = 4e-17
Identities = 47/129 (36%), Positives = 68/129 (52%), Gaps = 3/129 (2%)
Query: 11 RVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISILS 70
R+LIAK G DGHDRGAKV+A A D G++V + + TP +G S L+
Sbjct: 586 RILIAKMGQDGHDRGAKVIASAYSDLGFDVDLSPMFSTPEEIARLAVENDVHVVGASSLA 645
Query: 71 GAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKEII 130
H G ED+ V+AGG+IPP D L++ GVA ++GPGTP+ + +
Sbjct: 646 AGHKTLIPELVEALKKWG---REDICVVAGGVIPPQDYAFLQERGVAAIYGPGTPMLDSV 702
Query: 131 EFIDNNVGK 139
+ N + +
Sbjct: 703 RDVLNLISQ 711
>pir||D65076 sbm protein - Escherichia coli >gi|882446|gb|AAA69084.1| (U28377)
sbm gene product [Escherichia coli]
>gi|1789284|gb|AAC75954.1| (AE000375) methylmalonyl-CoA
mutase (MCM) [Escherichia coli K12]
Length = 714
Score = 88.2 bits (215), Expect = 4e-17
Identities = 47/129 (36%), Positives = 68/129 (52%), Gaps = 3/129 (2%)
Query: 11 RVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISILS 70
R+LIAK G DGHDRGAKV+A A D G++V + + TP +G S L+
Sbjct: 586 RILIAKMGQDGHDRGAKVIASAYSDLGFDVDLSPMFSTPEEIARLAVENDVHVVGASSLA 645
Query: 71 GAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKEII 130
H G ED+ V+AGG+IPP D L++ GVA ++GPGTP+ + +
Sbjct: 646 AGHKTLIPELVEALKKWG---REDICVVAGGVIPPQDYAFLQERGVAAIYGPGTPMLDSV 702
Query: 131 EFIDNNVGK 139
+ N + +
Sbjct: 703 RDVLNLISQ 711
>gi|4557767 methylmalonyl Coenzyme A mutase precursor [Homo sapiens]
>gi|547946|sp|P22033|MUTA_HUMAN METHYLMALONYL-COA
MUTASE, MITOCHONDRIAL PRECURSOR (MCM)
>gi|7513150|pir||A59145 methylmalonyl-CoA mutase (EC
5.4.99.2) precursor [validated] - human
>gi|187452|gb|AAA59569.1| (M65131) methylmalonyl-CoA
mutase [Homo sapiens]
Length = 750
Score = 87.8 bits (214), Expect = 6e-17
Identities = 51/142 (35%), Positives = 74/142 (51%), Gaps = 4/142 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 611 EGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVG 670
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H G D+LV+ GG+IPP D E L ++GV+ VFGPGT
Sbjct: 671 VSTLAAGHKTLVPELIKELNSLG---RPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTR 727
Query: 126 L-KEIIEFIDNNVGKLKKFRNS 146
+ K ++ +D+ L+K + S
Sbjct: 728 IPKAAVQVLDDIEKCLEKKQQS 749
>pir||S40622 methylmalonyl CoA mutase precursor - human
Length = 742
Score = 87.8 bits (214), Expect = 6e-17
Identities = 51/142 (35%), Positives = 74/142 (51%), Gaps = 4/142 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 603 EGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVG 662
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H G D+LV+ GG+IPP D E L ++GV+ VFGPGT
Sbjct: 663 VSTLAAGHKTLVPELIKELNSLG---RPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTR 719
Query: 126 L-KEIIEFIDNNVGKLKKFRNS 146
+ K ++ +D+ L+K + S
Sbjct: 720 IPKAAVQVLDDIEKCLEKKQQS 741
>gb|AAA99226.1| (M37510) methylmalonyl-CoA mutase [Homo sapiens]
Length = 750
Score = 87.8 bits (214), Expect = 6e-17
Identities = 51/142 (35%), Positives = 74/142 (51%), Gaps = 4/142 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 611 EGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVG 670
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H G D+LV+ GG+IPP D E L ++GV+ VFGPGT
Sbjct: 671 VSTLAAGHKTLVPELIKELNSLG---RPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTR 727
Query: 126 L-KEIIEFIDNNVGKLKKFRNS 146
+ K ++ +D+ L+K + S
Sbjct: 728 IPKAAVQVLDDIEKCLEKKQQS 749
>dbj|BAB06674.1| (AP001517) methylmalonyl-CoA mutase alpha subunit [Bacillus
halodurans]
Length = 716
Score = 87.8 bits (214), Expect = 6e-17
Identities = 48/119 (40%), Positives = 62/119 (51%), Gaps = 3/119 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+++AK G DGHDRGAKV+A A D G++V + QTP LG
Sbjct: 578 EGRRPRIMVAKMGQDGHDRGAKVIATAFADMGFDVDIGPLFQTPEEAALQAVENDVHVLG 637
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGT 124
+S L+ H G ED++VI GG+IPP D + LK G A VFGPGT
Sbjct: 638 MSSLAAGHKTLLPQVVDELKKLG---REDIMVIIGGVIPPQDYDFLKAHGAAAVFGPGT 693
>emb|CAC17595.1| (AJ300476) methylmalonyl-CoA mutase [Bos taurus]
Length = 750
Score = 87.8 bits (214), Expect = 6e-17
Identities = 51/142 (35%), Positives = 74/142 (51%), Gaps = 4/142 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 611 EGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHTVG 670
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H G D+LV+ GG+IPP D E L ++GV+ VFGPGT
Sbjct: 671 VSTLAAGHKTLVPELIKELNALG---RPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTR 727
Query: 126 L-KEIIEFIDNNVGKLKKFRNS 146
+ K ++ +D+ L+K + S
Sbjct: 728 IPKAAVQVLDDIEKCLEKKQQS 749
>pir||S13043 methylmalonyl-CoA mutase (EC 5.4.99.2) - mouse
Length = 748
Score = 86.6 bits (211), Expect = 1e-16
Identities = 47/131 (35%), Positives = 69/131 (51%), Gaps = 4/131 (3%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 609 EGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQHAVDADVHAVG 668
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H G D+LV+ GG+IPP D E L ++GV+ VFGPGT
Sbjct: 669 VSTLAAGHKTLVPELIKELTALG---RPDILVMCGGVIPPQDYEFLYEVGVSNVFGPGTR 725
Query: 126 L-KEIIEFIDN 135
+ + ++ +D+
Sbjct: 726 IPRAAVQVLDD 736
>gb|AAB31158.1| methylmalonyl CoA mutase, MCM {EC 5.4.99.2} [human, mut-
methylmalonic acidemia patient, Peptide Partial Mutant,
274 aa]
Length = 274
Score = 86.6 bits (211), Expect = 1e-16
Identities = 51/142 (35%), Positives = 74/142 (51%), Gaps = 4/142 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 135 EGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVG 194
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H G D+LV+ GG+IPP D E L ++GV+ VFGPGT
Sbjct: 195 VSTLAAGHKTLVPELIKELNSLGW---PDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTR 251
Query: 126 L-KEIIEFIDNNVGKLKKFRNS 146
+ K ++ +D+ L+K + S
Sbjct: 252 IPKAAVQVLDDIEKCLEKKQQS 273
>sp|O86028|MUTB_RHIME METHYLMALONYL-COA MUTASE (MCM) >gi|3549312|gb|AAD13665.1|
(AF080073) methylmalonyl-CoA mutase [Sinorhizobium
meliloti]
Length = 712
Score = 86.6 bits (211), Expect = 1e-16
Identities = 44/116 (37%), Positives = 62/116 (52%), Gaps = 3/116 (2%)
Query: 9 KVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISI 68
K ++++AK G DGHDRGAKV+A A D G++V+ + QTP +G+S
Sbjct: 580 KPKIMVAKLGQDGHDRGAKVIASAFGDIGFDVVAGPLFQTPEEAADLALAEEVTVIGVSS 639
Query: 69 LSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGT 124
L+ H G ED++V+ GG+IP D + L + GVA VFGPGT
Sbjct: 640 LAAGHRTLMPQLAEALKKRG---GEDIIVVCGGVIPRQDYDYLMENGVAAVFGPGT 692
>sp|P11653|MUTB_PROFR METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM-ALPHA)
>gi|80621|pir||S04641 methylmalonyl-CoA mutase (EC
5.4.99.2) alpha chain - Propionibacterium freudenreichii
subsp. shermanii >gi|581476|emb|CAA33090.1| (X14965)
mutB product, methylmalonyl-CoA mutase alpha-subunit (AA
1-728) [Propionibacterium freudenreichii subsp.
shermanii]
Length = 728
Score = 85.0 bits (207), Expect = 4e-16
Identities = 48/141 (34%), Positives = 70/141 (49%), Gaps = 9/141 (6%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRG KV+A A D G++V + QTP +G
Sbjct: 594 EGRRPRILLAKMGQDGHDRGQKVIATAYADLGFDVDVGPLFQTPEETARQAVEADVHVVG 653
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+G H+ G D+L+ GG+IP D +EL+K G E++ PGT
Sbjct: 654 VSSLAGGHLTLVPALRKELDKLG---RPDILITVGGVIPEQDFDELRKDGAVEIYTPGTV 710
Query: 126 LKEIIEFIDNNVGKLKKFRNS 146
+ E + + +KK R S
Sbjct: 711 IPE------SAISLVKKLRAS 725
>sp|Q59677|MUTA_PORGI METHYLMALONYL-COA MUTASE BETA-SUBUNIT (MCB-BETA)
>gi|2126435|pir||JC4560 methylmalonyl-CoA mutase (EC
5.4.99.2) large chain - Porphyromonas gingivalis
>gi|463175|gb|AAB51084.1| (L30136) methylmalonyl-CoA
mutase beta-subunit [Porphyromonas gingivalis]
>gi|1586535|prf||2204234B methylmalonyl-CoA
mutase:SUBUNIT=large [Porphyromonas gingivalis]
Length = 715
Score = 85.0 bits (207), Expect = 4e-16
Identities = 47/121 (38%), Positives = 62/121 (50%), Gaps = 3/121 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R++IAK G DGHDRGAKVVA D G++V + QTP +G
Sbjct: 584 EGRQPRIMIAKMGQDGHDRGAKVVATGYADCGFDVDMGPLFQTPEEAARQAVENDVHVMG 643
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H G D+LV AGG+IP D + L + GVA +FGPGTP
Sbjct: 644 VSSLAAGHKTLIPQVIAELEKLG---RPDILVTAGGVIPAQDYDFLYQAGVAAIFGPGTP 700
Query: 126 L 126
+
Sbjct: 701 V 701
>pdb|6REQ|A Chain A, Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Coa Inhibitor
Complex >gi|3660443|pdb|6REQ|C Chain C,
Methylmalonyl-Coa Mutase, 3-Carboxypropyl-Coa Inhibitor
Complex >gi|4389055|pdb|4REQ|A Chain A,
Methylmalonyl-Coa Mutase Substrate Complex
>gi|4389057|pdb|4REQ|C Chain C, Methylmalonyl-Coa Mutase
Substrate Complex >gi|1942488|pdb|1REQ|A Chain A,
Methylmalonyl-Coa Mutase >gi|1942490|pdb|1REQ|C Chain C,
Methylmalonyl-Coa Mutase >gi|2914199|pdb|2REQ|A Chain A,
Methylmalonyl-Coa Mutase, Non-Productive Coa Complex, In
Open Conformation Representing Substrate-Free State
>gi|2914201|pdb|2REQ|C Chain C, Methylmalonyl-Coa
Mutase, Non-Productive Coa Complex, In Open Conformation
Representing Substrate-Free State >gi|2981906|pdb|3REQ|A
Chain A, Methylmalonyl-Coa Mutase, Substrate-Free State
(Poor Quality Structure) >gi|3660449|pdb|7REQ|A Chain A,
Methylmalonyl-Coa Mutase, 2-Carboxypropyl-Coa Inhibitor
Complex >gi|3660451|pdb|7REQ|C Chain C,
Methylmalonyl-Coa Mutase, 2-Carboxypropyl-Coa Inhibitor
Complex
Length = 727
Score = 85.0 bits (207), Expect = 4e-16
Identities = 48/141 (34%), Positives = 70/141 (49%), Gaps = 9/141 (6%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRG KV+A A D G++V + QTP +G
Sbjct: 593 EGRRPRILLAKMGQDGHDRGQKVIATAYADLGFDVDVGPLFQTPEETARQAVEADVHVVG 652
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+G H+ G D+L+ GG+IP D +EL+K G E++ PGT
Sbjct: 653 VSSLAGGHLTLVPALRKELDKLG---RPDILITVGGVIPEQDFDELRKDGAVEIYTPGTV 709
Query: 126 LKEIIEFIDNNVGKLKKFRNS 146
+ E + + +KK R S
Sbjct: 710 IPE------SAISLVKKLRAS 724
>pdb|5REQ|A Chain A, Methylmalonyl-Coa Mutase, Y89f Mutant, Substrate Complex
>gi|7546643|pdb|5REQ|C Chain C, Methylmalonyl-Coa
Mutase, Y89f Mutant, Substrate Complex
Length = 727
Score = 85.0 bits (207), Expect = 4e-16
Identities = 48/141 (34%), Positives = 70/141 (49%), Gaps = 9/141 (6%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRG KV+A A D G++V + QTP +G
Sbjct: 593 EGRRPRILLAKMGQDGHDRGQKVIATAYADLGFDVDVGPLFQTPEETARQAVEADVHVVG 652
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+G H+ G D+L+ GG+IP D +EL+K G E++ PGT
Sbjct: 653 VSSLAGGHLTLVPALRKELDKLG---RPDILITVGGVIPEQDFDELRKDGAVEIYTPGTV 709
Query: 126 LKEIIEFIDNNVGKLKKFRNS 146
+ E + + +KK R S
Sbjct: 710 IPE------SAISLVKKLRAS 724
>pdb|1E1C|A Chain A, Methylmalonyl-Coa Mutase H244a Mutant
>gi|8569649|pdb|1E1C|C Chain C, Methylmalonyl-Coa Mutase
H244a Mutant
Length = 727
Score = 85.0 bits (207), Expect = 4e-16
Identities = 48/141 (34%), Positives = 70/141 (49%), Gaps = 9/141 (6%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRG KV+A A D G++V + QTP +G
Sbjct: 593 EGRRPRILLAKMGQDGHDRGQKVIATAYADLGFDVDVGPLFQTPEETARQAVEADVHVVG 652
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+G H+ G D+L+ GG+IP D +EL+K G E++ PGT
Sbjct: 653 VSSLAGGHLTLVPALRKELDKLG---RPDILITVGGVIPEQDFDELRKDGAVEIYTPGTV 709
Query: 126 LKEIIEFIDNNVGKLKKFRNS 146
+ E + + +KK R S
Sbjct: 710 IPE------SAISLVKKLRAS 724
>sp|Q05065|MUTB_STRCM METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM-ALPHA)
>gi|538979|pir||B40595 methylmalonyl-CoA mutase (EC
5.4.99.2) mutB chain - Streptomyces cinnamonensis
>gi|153367|gb|AAA03041.1| (L10064) methylmalonyl-CoA
large subunit [Streptomyces cinnamonensis]
Length = 733
Score = 84.7 bits (206), Expect = 5e-16
Identities = 42/123 (34%), Positives = 62/123 (50%), Gaps = 3/123 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+AK G DGHDRG KV+A A D G++V + QTP +G
Sbjct: 597 EGRRPRILVAKMGQDGHDRGQKVIASAFADLGFDVDVGPLFQTPAEVARQAVEADVHIVG 656
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S L+ H+ G +D++++ GG+IPP D E L + G VF PGT
Sbjct: 657 VSSLAAGHLTLVPALREELAAEG---RDDIMIVVGGVIPPQDVEALHEAGATAVFPPGTV 713
Query: 126 LKE 128
+ +
Sbjct: 714 IPD 716
>sp|Q49115|MEAA_METEX MEAA PROTEIN >gi|1098584|gb|AAC44087.1| (U28335) MeaA
[Methylobacterium extorquens]
Length = 688
Score = 83.5 bits (203), Expect = 1e-15
Identities = 43/112 (38%), Positives = 60/112 (53%), Gaps = 3/112 (2%)
Query: 11 RVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISILS 70
R+++ KPGLDGH GA+ +A RD G++V Y GIRQTP +G+S+LS
Sbjct: 532 RLVVGKPGLDGHSNGAEQIALRARDVGFDVTYDGIRQTPTEIVAKAKERGAHVIGLSVLS 591
Query: 71 GAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGP 122
G+H+ G+ + V V+ GGII +D LK MGV V+ P
Sbjct: 592 GSHVPLVREVKAKLREAGL---DHVPVVVGGIISTEDELVLKNMGVTAVYTP 640
>gi|6678970 methylmalonyl-Coenzyme A mutase [Mus musculus]
>gi|127548|sp|P16332|MUTA_MOUSE METHYLMALONYL-COA
MUTASE, MITOCHONDRIAL PRECURSOR (MCM)
>gi|91084|pir||S08680 methylmalonyl-CoA mutase (EC
5.4.99.2) precursor - mouse >gi|53151|emb|CAA36204.1|
(X51941) precursor polypeptide (AA -30 to 718) [Mus
musculus]
Length = 748
Score = 82.3 bits (200), Expect = 2e-15
Identities = 45/131 (34%), Positives = 68/131 (51%), Gaps = 4/131 (3%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E ++ +L+AK G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 609 EGRRLGLLVAKMGKDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAHDAVDADVHAVG 668
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S + H G D+LV+ GG+IPP D E L ++GV+ VFGPGT
Sbjct: 669 VSTHAAGHKTLVPELIKELTALG---RPDILVMCGGVIPPQDYEFLYEVGVSNVFGPGTR 725
Query: 126 L-KEIIEFIDN 135
+ + ++ +D+
Sbjct: 726 IPRAAVQVLDD 736
>pir||F75440 methylmalonyl-CoA mutase, beta subunit - Deinococcus radiodurans
(strain R1) >gi|6458814|gb|AAF10655.1|AE001958_9
(AE001958) methylmalonyl-CoA mutase, beta subunit
[Deinococcus radiodurans]
Length = 711
Score = 80.8 bits (196), Expect = 7e-15
Identities = 42/121 (34%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 6 ERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLG 65
E + R+L+ K G DGHDRGAKV+A D G++V + QTP +G
Sbjct: 581 EGRRPRILVVKMGQDGHDRGAKVIATGFADLGFDVDVGPLFQTPEEAARQAVENDVHVVG 640
Query: 66 ISILSGAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTP 125
+S + H G D+LV+ GG+IP D L++ G A +FGPGTP
Sbjct: 641 VSSQAAGHKTLVPQLIQALRAEGA---GDILVVVGGVIPQQDYPALREAGAAGIFGPGTP 697
Query: 126 L 126
+
Sbjct: 698 I 698
>sp|P71774|MUTB_MYCTU PROBABLE METHYLMALONYL-COA MUTASE LARGE SUBUNIT (MCM)
>gi|7478453|pir||H70711 probable mutB protein -
Mycobacterium tuberculosis (strain H37RV)
>gi|1524240|emb|CAB02043.1| (Z79701) mutB [Mycobacterium
tuberculosis]
Length = 750
Score = 80.4 bits (195), Expect = 9e-15
Identities = 40/118 (33%), Positives = 58/118 (48%), Gaps = 3/118 (2%)
Query: 11 RVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPXXXXXXXXXXXXXXLGISILS 70
R+LIAK G DGHDRG KV+A A D G++V + TP +G+S L+
Sbjct: 618 RILIAKMGQDGHDRGQKVIATAFADIGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLA 677
Query: 71 GAHMVXXXXXXXXXXXXGVKVNEDVLVIAGGIIPPDDAEELKKMGVAEVFGPGTPLKE 128
H+ G D++++ GG+IPP D +EL G +F PGT + +
Sbjct: 678 AGHLTLVPALRDALAQVG---RPDIMIVVGGVIPPGDFDELYAAGATAIFPPGTVIAD 732
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.142 0.398
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44634087
Number of Sequences: 2977
Number of extensions: 1433998
Number of successful extensions: 3643
Number of sequences better than 1.0e-10: 35
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 3598
Number of HSP's gapped (non-prelim): 35
length of query: 146
length of database: 189,106,746
effective HSP length: 53
effective length of query: 93
effective length of database: 157,386,935
effective search space: 14636984955
effective search space used: 14636984955
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 161 (67.1 bits)