BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2264 (mtaP) DE:methylthioadenosine phosphorylase (mtaP)
(257 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||H75199 methylthioadenosine phosphorylase (mtap) PAB2264 - P... 532 e-150
sp|O57865|Y125_PYRHO HYPOTHETICAL PROTEIN PH0125 >gi|7450057|pir... 518 e-146
emb|CAC11476.1| (AL445064) purine-nucleoside phosphorylase relat... 352 3e-96
gb|AAK42494.1| 5'-methylthioadenosine phosphorylase (mtaP) [Sulf... 326 2e-88
pir||E72575 probable 5'-methylthioadenosine phosphorylase APE188... 310 1e-83
pir||D75085 methylthioadenosine phosphorylase related (mtap) PAB... 264 9e-70
pir||A71056 probable 5'-methylthioadenosine phosphorylase - Pyro... 263 2e-69
pir||C70351 purine nucleoside phosphorylase - Aquifex aeolicus >... 244 9e-64
pdb|1CG6|A Chain A, Structure Of Human 5'-Deoxy-5'-Methylthioade... 241 6e-63
gi|4505273 5'-methylthioadenosine phosphorylase [Homo sapiens] >... 241 8e-63
gb|AAG38871.1|L40432_1 (L40432) methylthioadenosine phosphorylas... 240 1e-62
sp|Q60367|Y060_METJA HYPOTHETICAL PROTEIN MJ0060 >gi|2127724|pir... 218 5e-56
gb|AAF57869.1| (AE003803) CG4802 gene product [Drosophila melano... 217 1e-55
emb|CAB90972.1| (AL355832) putative methylthioadenosine phosphor... 216 2e-55
pir||B70546 probable pnp protein - Mycobacterium tuberculosis (s... 203 2e-51
pir||A69080 methylthioadenosine phosphorylase - Methanobacterium... 194 7e-49
pir||S76441 hypothetical protein - Synechocystis sp. (strain PCC... 194 9e-49
emb|CAB75631.1| (AL157415) 5'-methylthioadenosine phosphorylase ... 190 1e-47
sp|Q09438|MTAP_CAEEL PUTATIVE 5'-METHYLTHIOADENOSINE PHOSPHORYLA... 187 9e-47
sp|Q09816|YAC2_SCHPO HYPOTHETICAL 33.9 KD PROTEIN C16C9.02C IN C... 172 4e-42
pir||F83270 probable nucleoside phosphorylase PA3004 [imported] ... 165 6e-40
pir||H82568 purine nucleoside phosphorylase XF2353 [imported] - ... 162 4e-39
gi|11499377 methylthioadenosine phosphorylase (mtaP) [Archaeoglo... 160 1e-38
emb|CAA62156.1| (X90564) orf [Saccharomyces cerevisiae] 160 2e-38
gi|6323045 regulator of ADH2 expression; Meu1p [Saccharomyces ce... 159 4e-38
pir||H72217 purine nucleoside phosphorylase - Thermotoga maritim... 108 1e-22
dbj|BAB05251.1| (AP001512) purine nucleoside phosphorylase [Baci... 107 1e-22
sp|P23139|YPE2_RHORU HYPOTHETICAL 25.8 KD PROTEIN IN PETC 3'REGI... 106 4e-22
gb|AAD19641.1| (AF109294) hypothetical methylthioadenosine phosp... 104 9e-22
emb|CAB61871.1| (AL133252) putative phosphorylase [Streptomyces ... 101 1e-20
sp|P77834|PUNA_BACST PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (... 94 1e-18
sp|P46354|PUNA_BACSU PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (... 91 1e-17
pdb|1FXU|A Chain A, Purine Nucleoside Phosphorylase From Calf Sp... 88 9e-17
pdb|1PBN| Purine Nucleoside Phosphorylase >gi|4699623|pdb|4PNP... 88 1e-16
pdb|1VFN| Purine Nucleoside Phosphorylase 88 1e-16
pdb|1A9T| Bovine Purine Nucleoside Phosphorylase Complexed Wit... 88 1e-16
pdb|1A9P| Bovine Purine Nucleoside Phosphorylase Complexed Wit... 88 1e-16
pir||S66203 purine-nucleoside phosphorylase (EC 2.4.2.1) - bovin... 87 2e-16
sp|P55859|PNPH_BOVIN PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PH... 87 2e-16
pdb|1B8O|A Chain A, Purine Nucleoside Phosphorylase >gi|4558113|... 87 2e-16
pir||T37901 probable purine nucleoside phosphorylase - fission y... 87 3e-16
gi|4557801 purine nucleoside phosphorylase [Homo sapiens] >gi|13... 86 5e-16
gb|AAA36460.1| (M13953) purine nucleoside phosphorylase [Homo sa... 86 5e-16
gi|11437430 purine nucleoside phosphorylase [Homo sapiens] 85 6e-16
pdb|1A9Q| Bovine Purine Nucleoside Phosphorylase Complexed Wit... 85 8e-16
dbj|BAB05250.1| (AP001512) purine nucleoside phosphorylase [Baci... 85 8e-16
gi|7305395 purine-nucleoside phopshorylase [Mus musculus] >gi|53... 81 1e-14
gb|AAC37635.1| (L11291) purine nucleoside phosphorylase [Mus mus... 81 1e-14
sp|P23492|PNPH_MOUSE PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PH... 81 2e-14
pir||I76672 purine-nucleoside phosphorylase (EC 2.4.2.1) - weste... 81 2e-14
pir||H72233 purine nucleoside phosphorylase - Thermotoga maritim... 80 4e-14
sp|P45563|XAPA_ECOLI XANTHOSINE PHOSPHORYLASE >gi|7433918|pir||F... 75 7e-13
gb|AAF47653.1| (AE003475) CG16758 gene product [alt 4] [Drosophi... 74 2e-12
gb|AAF47654.1| (AE003475) CG16758 gene product [alt 3] [Drosophi... 74 2e-12
gb|AAF47655.1| (AE003475) CG16758 gene product [alt 2] [Drosophi... 74 2e-12
gb|AAF47656.1| (AE003475) CG16758 gene product [alt 1] [Drosophi... 74 2e-12
gi|6323238 Purine Nucleoside Phosphorylase; Pnp1p [Saccharomyces... 72 6e-12
pir||T32981 hypothetical protein K02D7.1 - Caenorhabditis elegan... 70 3e-11
>pir||H75199 methylthioadenosine phosphorylase (mtap) PAB2264 - Pyrococcus
abyssi (strain Orsay) >gi|5457556|emb|CAB49047.1|
(AJ248283) methylthioadenosine phosphorylase (mtaP)
[Pyrococcus abyssi]
Length = 257
Score = 532 bits (1356), Expect = e-150
Identities = 257/257 (100%), Positives = 257/257 (100%)
Query: 1 MPKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
MPKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH
Sbjct: 1 MPKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV 120
EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV
Sbjct: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV 120
Query: 121 AHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM 180
AHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM
Sbjct: 121 AHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM 180
Query: 181 TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVNAQEVLRVMKENEEKVQKLLRKAIPKI 240
TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVNAQEVLRVMKENEEKVQKLLRKAIPKI
Sbjct: 181 TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVNAQEVLRVMKENEEKVQKLLRKAIPKI 240
Query: 241 PEERKCGCADVLKTMFV 257
PEERKCGCADVLKTMFV
Sbjct: 241 PEERKCGCADVLKTMFV 257
>sp|O57865|Y125_PYRHO HYPOTHETICAL PROTEIN PH0125 >gi|7450057|pir||C71233 probable
5'-methylthioadenosine phosphorylase - Pyrococcus
horikoshii >gi|3256511|dbj|BAA29194.1| (AP000001) 260aa
long hypothetical 5'-methylthioadenosine phosphorylase
[Pyrococcus horikoshii]
Length = 260
Score = 518 bits (1321), Expect = e-146
Identities = 245/257 (95%), Positives = 256/257 (99%)
Query: 1 MPKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
MPKIGIIGGSGVYGVFEPKEVVK+HTPYGRPSAP+EIGEIEGVEVAFIPRHGKYHEFPPH
Sbjct: 4 MPKIGIIGGSGVYGVFEPKEVVKVHTPYGRPSAPIEIGEIEGVEVAFIPRHGKYHEFPPH 63
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV 120
+VPYRANIWAL+ELGVER+IAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV
Sbjct: 64 QVPYRANIWALHELGVERVIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV 123
Query: 121 AHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM 180
AHVSMADPFCPELR+IFIETAKEL LPVHE+GTY+CIEGPRFSTRAESRMFRQFADVIGM
Sbjct: 124 AHVSMADPFCPELRKIFIETAKELNLPVHERGTYVCIEGPRFSTRAESRMFRQFADVIGM 183
Query: 181 TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVNAQEVLRVMKENEEKVQKLLRKAIPKI 240
TLVPEVNLARELGMCYVNISTVTDYDVWAEKPV+AQEVLRVMKENEEKVQKLL++AIPKI
Sbjct: 184 TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKI 243
Query: 241 PEERKCGCADVLKTMFV 257
PEERKCGCADVLKTMFV
Sbjct: 244 PEERKCGCADVLKTMFV 260
>emb|CAC11476.1| (AL445064) purine-nucleoside phosphorylase related protein
[Thermoplasma acidophilum]
Length = 261
Score = 352 bits (893), Expect = 3e-96
Identities = 162/249 (65%), Positives = 202/249 (81%)
Query: 1 MPKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
M IGIIGGSG+Y + I TP+G PS VEIGE+ GVEVAF+PRHGK H PPH
Sbjct: 5 MAYIGIIGGSGLYDLMPESTKKVIETPFGNPSDAVEIGEVNGVEVAFLPRHGKKHTIPPH 64
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV 120
+V YRANIWAL+ELGVERII +NAVGSL+E+YKPG+IVI DQ+IDFTK+R+ TFY+GP+V
Sbjct: 65 KVNYRANIWALHELGVERIIGLNAVGSLREDYKPGEIVIPDQYIDFTKRRDLTFYDGPQV 124
Query: 121 AHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM 180
H+S ADPFCPE+ I +TA+ L +PVH GTYI IEGPRFSTRAES+MFRQFAD+IGM
Sbjct: 125 YHISEADPFCPEMNSILYDTARNLKIPVHNSGTYITIEGPRFSTRAESKMFRQFADIIGM 184
Query: 181 TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVNAQEVLRVMKENEEKVQKLLRKAIPKI 240
TLVPEV+LA EL +CY I+++TDYDVW+ KPV+A+EV+ +MK+N+ KV+ +L A+P I
Sbjct: 185 TLVPEVSLAGELALCYSVIASITDYDVWSTKPVDAREVMNIMKQNDHKVRDILFNALPLI 244
Query: 241 PEERKCGCA 249
+ERKC C+
Sbjct: 245 KKERKCSCS 253
>gb|AAK42494.1| 5'-methylthioadenosine phosphorylase (mtaP) [Sulfolobus
solfataricus]
Length = 270
Score = 326 bits (827), Expect = 2e-88
Identities = 163/261 (62%), Positives = 197/261 (75%), Gaps = 7/261 (2%)
Query: 4 IGIIGGSGVY--GVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHE 61
IGIIGGSG+Y G+F + +K++TPYG+PS + IG+I VAF+PRHG+ H PPH+
Sbjct: 10 IGIIGGSGLYDPGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHGRGHRIPPHK 69
Query: 62 VPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVA 121
+ YRANIWAL ELGV +I+++AVGSL+ +YK GD VI DQFID TK REY+F++GP VA
Sbjct: 70 INYRANIWALKELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREYSFFDGPVVA 129
Query: 122 HVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQF--ADVIG 179
HVSMADPFC LR++ IETAKEL + HE GTYICIEGPRFSTRAESR +R+ AD+IG
Sbjct: 130 HVSMADPFCNSLRKLAIETAKELNIKTHESGTYICIEGPRFSTRAESRTWREVYKADIIG 189
Query: 180 MTLVPEVNLARELGMCYVNISTVTDYDVWAEKPVNAQEVLRVMKENEEKVQKLLRKAIPK 239
MTLVPEVNLA E MCY I+ VTDYDV+AE PV A+EV RVM EN EK +KLL I K
Sbjct: 190 MTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAKKLLYALIQK 249
Query: 240 I---PEERKCGCADVLKTMFV 257
+ PEE C C + LKT V
Sbjct: 250 LPEKPEEGSCSCCNSLKTALV 270
>pir||E72575 probable 5'-methylthioadenosine phosphorylase APE1885 - Aeropyrum
pernix (strain K1) >gi|5105577|dbj|BAA80890.1|
(AP000062) 275aa long hypothetical
5'-methylthioadenosine phosphorylase [Aeropyrum pernix]
Length = 275
Score = 310 bits (786), Expect = 1e-83
Identities = 146/259 (56%), Positives = 194/259 (74%), Gaps = 8/259 (3%)
Query: 4 IGIIGGSGVY--GVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHE 61
+G+IGGSG+Y G+ E VK+ TPYG PS + +G++ GV+VAF+PRHG+ H PPH
Sbjct: 14 VGVIGGSGLYDPGIVENPVEVKVSTPYGNPSDFIVVGDVAGVKVAFLPRHGRGHRIPPHA 73
Query: 62 VPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTK-KREYTFYNGPKV 120
+ YRANIWAL LGV+ +I+++AVGSL+E+Y+PGD V+ DQFID TK +R YTFY+GP
Sbjct: 74 INYRANIWALKALGVKWVISVSAVGSLREDYRPGDFVVPDQFIDMTKNRRHYTFYDGPVT 133
Query: 121 AHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQF--ADVI 178
HVSMADPFC +LR+ I++ + LG VHE+GTY+CIEGPRFSTRAESR+++ AD+I
Sbjct: 134 VHVSMADPFCEDLRQRLIDSGRRLGYTVHERGTYVCIEGPRFSTRAESRVWKDVFKADII 193
Query: 179 GMTLVPEVNLARELGMCYVNISTVTDYDVWAEKPVNAQEVLRVMKENEEKVQKLLRKAIP 238
GMTLVPE+NLA E +CY ++ VTDYDVWA++PV A+EV RVM N E+ +++L IP
Sbjct: 194 GMTLVPEINLACEAQLCYATLAMVTDYDVWADRPVTAEEVERVMISNVERARRMLYDVIP 253
Query: 239 KI---PEERKCGCADVLKT 254
K+ PE +C C L T
Sbjct: 254 KLAGEPELERCSCCRALDT 272
>pir||D75085 methylthioadenosine phosphorylase related (mtap) PAB1659 -
Pyrococcus abyssi (strain Orsay)
>gi|5458497|emb|CAB49985.1| (AJ248286)
methylthioadenosine phosphorylase related (mtaP)
[Pyrococcus abyssi]
Length = 265
Score = 264 bits (667), Expect = 9e-70
Identities = 135/263 (51%), Positives = 172/263 (65%), Gaps = 12/263 (4%)
Query: 1 MPKIGIIGGSGVYGV-FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPP 59
M ++ +IGGSGVY E K V + TPYG+ V IG + G EVAF+ RHGK H PP
Sbjct: 1 MVRVAVIGGSGVYDFPAENKRSVTVETPYGK--VEVTIGLVNGEEVAFLARHGKGHSIPP 58
Query: 60 HEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK 119
H++ YRANIWALYELGVERIIA +AVGS+ +PGD VI+DQ IDFT R TFY+G +
Sbjct: 59 HKINYRANIWALYELGVERIIATSAVGSMNPNMRPGDFVILDQIIDFTVSRPRTFYDGEE 118
Query: 120 -------VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFR 172
VAHV +P+CPE+RR I AKEL LP H +GTY+C EGPRF T AE + +R
Sbjct: 119 SPHDRKFVAHVDFTEPYCPEIRRALIAAAKELSLPYHPRGTYVCTEGPRFETAAEIKAYR 178
Query: 173 QF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRVMKENEEKVQ 230
DV+GMT PE LAREL +CY ++ VT+Y + K + EV+ +M + +++
Sbjct: 179 ILGGDVVGMTQCPEAILARELEICYATVAIVTNYAAGISGKKLTHSEVVELMNKKSKEIV 238
Query: 231 KLLRKAIPKIPEERKCGCADVLK 253
L+ KAIP IP+ER C C D LK
Sbjct: 239 ALITKAIPLIPKERNCPCKDALK 261
>pir||A71056 probable 5'-methylthioadenosine phosphorylase - Pyrococcus
horikoshii >gi|3257560|dbj|BAA30243.1| (AP000005) 265aa
long hypothetical 5'-methylthioadenosine phosphorylase
[Pyrococcus horikoshii]
Length = 265
Score = 263 bits (665), Expect = 2e-69
Identities = 135/263 (51%), Positives = 172/263 (65%), Gaps = 12/263 (4%)
Query: 1 MPKIGIIGGSGVYGV-FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPP 59
M ++ +IGGSGVY E K + + TPYG+ + + IG + G EVAF+ RHGK H PP
Sbjct: 1 MVRVAVIGGSGVYDFPAENKRELTVETPYGKVN--LTIGHVAGEEVAFLARHGKGHSVPP 58
Query: 60 HEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK 119
H+V YRANIWAL+ELGVERI+A +AVGSL +PGD VI+DQ IDFT R TFY+G +
Sbjct: 59 HKVNYRANIWALHELGVERIVATSAVGSLNPNMRPGDFVILDQLIDFTVSRPRTFYDGEE 118
Query: 120 -------VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFR 172
VAHV +P+CPE+RR I AK+L LP H KGTY+C EGPRF T AE R +R
Sbjct: 119 SPHDRKFVAHVDFTEPYCPEIRRALITAAKDLSLPYHPKGTYVCTEGPRFETAAEIRAYR 178
Query: 173 QF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRVMKENEEKVQ 230
DV+GMT PE LAREL MCY ++ VT+Y + K + EV+ +M + ++
Sbjct: 179 ILGGDVVGMTQCPEAALARELEMCYATVAIVTNYAAGISGKKLTHAEVVELMNKKTREIT 238
Query: 231 KLLRKAIPKIPEERKCGCADVLK 253
L+ KAIP IP+ER C C D LK
Sbjct: 239 ALITKAIPLIPKERNCPCKDALK 261
>pir||C70351 purine nucleoside phosphorylase - Aquifex aeolicus
>gi|2983202|gb|AAC06801.1| (AE000696) purine nucleoside
phosphorylase [Aquifex aeolicus]
Length = 277
Score = 244 bits (616), Expect = 9e-64
Identities = 122/272 (44%), Positives = 174/272 (63%), Gaps = 22/272 (8%)
Query: 4 IGIIGGSGVYGV--FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHE 61
+GIIGGSG+Y + + KE V++ TP+G PS+PV I E+EG +VAF+ RHG+ HE+PPH
Sbjct: 2 LGIIGGSGLYNLPGIKVKEEVQVKTPFGEPSSPVVIAEVEGKKVAFLARHGRGHEYPPHL 61
Query: 62 VPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGP--- 118
VPYRAN+WAL E+GV+R++ I+AVG + E PGD V+I ++DFTK R T+Y G
Sbjct: 62 VPYRANLWALREVGVKRVLGISAVGGINELLMPGDFVVIHDYLDFTKTRRSTYYEGKFSV 121
Query: 119 ---------------KVAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFS 163
KV HV M++ +CPE+R++ I+ KE H KG Y C EGPRF
Sbjct: 122 KVEGEDKVAKLLREGKVVHVDMSEAYCPEMRKVLIQILKEKNFRFHPKGVYACTEGPRFE 181
Query: 164 TRAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRV 221
T +E +M + ADV+GMT PEV LAREL MCY ++ V + A + + EV+++
Sbjct: 182 TPSEIKMLKLLGADVVGMTGYPEVALARELTMCYASLCVVANPAAGIAGYRLTSNEVIQL 241
Query: 222 MKENEEKVQKLLRKAIPKIPEERKCGCADVLK 253
MK EE++++++ K I ++PE R C C L+
Sbjct: 242 MKRKEEEIKEVVLKFIKELPEIRSCDCEKSLE 273
>pdb|1CG6|A Chain A, Structure Of Human 5'-Deoxy-5'-Methylthioadenosine
Phosphorylase Complexed With 5'-Deoxy-5'-
Methylthioadenosine And Sulfate At 1.7 A Resolution
>gi|5542154|pdb|1CB0|A Chain A, Structure Of Human
5'-Deoxy-5'-Methylthioadenosine Phosphorylase At 1.7 A
Resolution
Length = 283
Score = 241 bits (609), Expect = 6e-63
Identities = 126/248 (50%), Positives = 165/248 (65%), Gaps = 10/248 (4%)
Query: 3 KIGIIGGSGVYG--VFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
KIGIIGG+G+ + E + + TP+G+PS + +G+I+ V+ + RHG+ H P
Sbjct: 11 KIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPS 70
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK- 119
+V Y+ANIWAL E G +I A GSL+EE +PGDIVIIDQFID T R +FY+G
Sbjct: 71 KVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHS 130
Query: 120 ----VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQF- 174
V H+ MA+PFCP+ R + IETAK+LGL H KGT + IEGPRFS+RAES MFR +
Sbjct: 131 CARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWG 190
Query: 175 ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWA--EKPVNAQEVLRVMKENEEKVQKL 232
ADVI MT VPEV LA+E G+CY +I+ TDYD W E+ V+ VL+ +KEN K + L
Sbjct: 191 ADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSL 250
Query: 233 LRKAIPKI 240
L IP+I
Sbjct: 251 LLTTIPQI 258
>gi|4505273 5'-methylthioadenosine phosphorylase [Homo sapiens]
>gi|2494053|sp|Q13126|MTAP_HUMAN 5'-METHYLTHIOADENOSINE
PHOSPHORYLASE (MTA PHOSPHORYLASE) (MTAPASE)
>gi|2134671|pir||I38969 5'-methylthioadenosine
phosphorylase (EC 2.4.2.28) - human
>gi|847724|gb|AAA81646.1| (U22233) methylthioadenosine
phosphorylase [Homo sapiens]
Length = 283
Score = 241 bits (608), Expect = 8e-63
Identities = 126/248 (50%), Positives = 165/248 (65%), Gaps = 10/248 (4%)
Query: 3 KIGIIGGSGVYG--VFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
KIGIIGG+G+ + E + + TP+G+PS + +G+I+ V+ + RHG+ H P
Sbjct: 11 KIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCILLARHGRQHTIMPS 70
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK- 119
+V Y+ANIWAL E G +I A GSL+EE +PGDIVIIDQFID T R +FY+G
Sbjct: 71 KVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHS 130
Query: 120 ----VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQF- 174
V H+ MA+PFCP+ R + IETAK+LGL H KGT + IEGPRFS+RAES MFR +
Sbjct: 131 CARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWG 190
Query: 175 ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWA--EKPVNAQEVLRVMKENEEKVQKL 232
ADVI MT VPEV LA+E G+CY +I+ TDYD W E+ V+ VL+ +KEN K + L
Sbjct: 191 ADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSL 250
Query: 233 LRKAIPKI 240
L IP+I
Sbjct: 251 LLTTIPQI 258
>gb|AAG38871.1|L40432_1 (L40432) methylthioadenosine phosphorylase [Homo sapiens]
Length = 283
Score = 240 bits (606), Expect = 1e-62
Identities = 126/248 (50%), Positives = 165/248 (65%), Gaps = 10/248 (4%)
Query: 3 KIGIIGGSGVYG--VFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
KIGIIGG+G+ + E + + TP+G+PS + +G+I+ V+ + RHG+ H P
Sbjct: 11 KIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPS 70
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK- 119
+V Y+ANIWAL E G +I A GSL+EE +PGDIVIIDQFID T R +FY+G
Sbjct: 71 KVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHS 130
Query: 120 ----VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQF- 174
V H+ MA+PFCP+ R + IETAK+LGL H KGT + IEGPRFS+RAES MFR +
Sbjct: 131 CARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWG 190
Query: 175 ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWA--EKPVNAQEVLRVMKENEEKVQKL 232
ADVI MT VPEV LA+E G+CY +I+ TDYD W E+ V+ VL+ +KEN K + L
Sbjct: 191 ADVINMTTVPEVVLAKEAGICYASIAMGTDYDCWKEHEEAVSVDRVLKTLKENANKAKSL 250
Query: 233 LRKAIPKI 240
L IP+I
Sbjct: 251 LLTTIPQI 258
>sp|Q60367|Y060_METJA HYPOTHETICAL PROTEIN MJ0060 >gi|2127724|pir||D64307
5'-methylthioadenosine phosphorylase (EC 2.4.2.28) -
Methanococcus jannaschii >gi|1498822|gb|AAB98042.1|
(U67464) methylthioadenosine phosphorylase (mtaP)
[Methanococcus jannaschii]
Length = 252
Score = 218 bits (550), Expect = 5e-56
Identities = 115/251 (45%), Positives = 161/251 (63%), Gaps = 6/251 (2%)
Query: 4 IGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHEVP 63
IGIIGG+G+ + + + I+T YG+ ++ + EV + RHG H PPH++
Sbjct: 2 IGIIGGTGIAEILKGDKEEIINTKYGKARVIID----KENEVVLLFRHGVRHNIPPHKIN 57
Query: 64 YRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVAHV 123
YRANI+AL +LGVERI+AIN+VGSLKE+ KPG + + FI+FTKKRE TFY+ KV H+
Sbjct: 58 YRANIYALKKLGVERILAINSVGSLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHI 117
Query: 124 SMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGMTLV 183
M DP+CPELR I +++ + + +G Y+C EGPRF T+ E +++ + DV+GMT
Sbjct: 118 DMTDPYCPELRNI-LKSILDKNNFSYGEGVYVCTEGPRFETKKEIAIYKNWGDVVGMTGY 176
Query: 184 PEVNLARELGMCYVNISTVTDYDVWAEKPV-NAQEVLRVMKENEEKVQKLLRKAIPKIPE 242
PEV LAREL MCYV++ +T+Y K + EVL +KE E K+ K++ I
Sbjct: 177 PEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFG 236
Query: 243 ERKCGCADVLK 253
ERKC C D LK
Sbjct: 237 ERKCICKDALK 247
>gb|AAF57869.1| (AE003803) CG4802 gene product [Drosophila melanogaster]
Length = 289
Score = 217 bits (547), Expect = 1e-55
Identities = 117/251 (46%), Positives = 157/251 (61%), Gaps = 10/251 (3%)
Query: 3 KIGIIGGSGVYG--VFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
KIGIIGGSG+ + E ++ + TPYG PS + GEI GV+ + RHG+ H+ P
Sbjct: 17 KIGIIGGSGLDDPDILEQRQERVVETPYGEPSDALIEGEINGVQCVLLARHGRKHDIMPS 76
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPK- 119
V YRANIWAL ++G +I A GSL+EE KPG++V+ FID T KR TFY+G
Sbjct: 77 NVNYRANIWALRDVGCTHLIVSTACGSLREEIKPGNLVVPHDFIDRTTKRLQTFYDGKAQ 136
Query: 120 ----VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQF- 174
V H+ M F R I ++ AKEL +P H+K T + IEGPRFS+R+ES MFRQ+
Sbjct: 137 SPRGVCHLPMFPAFSERTRNILLQAAKELEIPAHDKATIVTIEGPRFSSRSESHMFRQWG 196
Query: 175 ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAE--KPVNAQEVLRVMKENEEKVQKL 232
D+I MT PEV LA+E G+ Y +++ TDYD W + VN Q+VLR EN KV+K+
Sbjct: 197 GDLINMTTCPEVVLAKEAGLLYGSVAIATDYDCWRMGCEGVNVQDVLRTFAENVIKVKKI 256
Query: 233 LRKAIPKIPEE 243
L A+ +I +E
Sbjct: 257 LVNAVGRIAKE 267
>emb|CAB90972.1| (AL355832) putative methylthioadenosine phosphorylase [Streptomyces
coelicolor A3(2)]
Length = 280
Score = 216 bits (544), Expect = 2e-55
Identities = 114/266 (42%), Positives = 162/266 (60%), Gaps = 13/266 (4%)
Query: 3 KIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHEV 62
+IG+IGGSG Y + V++ TPYG PS + +GE+ G VAF+PRHG+ H PPH +
Sbjct: 8 EIGVIGGSGFYSFLDDVTEVRVDTPYGPPSDSLFLGEVAGRRVAFLPRHGRGHHLPPHRI 67
Query: 63 PYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNG----- 117
YRAN+WAL +G +++ AVG L+ EY PG +++ DQF+D T+ R T+++G
Sbjct: 68 NYRANLWALRSVGARQVLGPCAVGGLRPEYGPGTLLVPDQFVDRTRSRPSTYFDGLPMPD 127
Query: 118 ---PKVAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFR-Q 173
P V HVS+ADP+CP R ++ A+ + GT + +EGPRF TRAES R Q
Sbjct: 128 GTVPNVVHVSLADPYCPTGRAAALKAARGREWEPVDGGTLVVVEGPRFGTRAESLWHRAQ 187
Query: 174 FADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAE--KPVNAQEVLRVMKENEEKVQK 231
V+GMT PE LAREL +CY +++ VTD D AE + V+ +EVLRV N ++++
Sbjct: 188 GWSVVGMTGHPEAALARELELCYTSLTLVTDLDAGAESGEGVSHEEVLRVFAANVDRLRG 247
Query: 232 LLRKAIPKIPE--ERKCGCADVLKTM 255
+L A+ +P ER C C L M
Sbjct: 248 VLFDAVAALPASGERDCPCGAALGGM 273
>pir||B70546 probable pnp protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2113997|emb|CAB08986.1| (Z95558) pnp [Mycobacterium
tuberculosis]
Length = 264
Score = 203 bits (510), Expect = 2e-51
Identities = 116/248 (46%), Positives = 153/248 (60%), Gaps = 12/248 (4%)
Query: 4 IGIIGGSGVYGVF-EPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHEV 62
+G+IGGSG Y F V TPYG+PSAP+ IG I +VAF+PRHG +H++ H V
Sbjct: 8 LGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGTIGVHDVAFLPRHGAHHQYSAHAV 67
Query: 63 PYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVAH 122
PYRAN+WAL LGV R+ AVGSL E +PG +V+ DQ +D T R T+++ V H
Sbjct: 68 PYRANMWALRALGVRRVFGPCAVGSLDPELEPGAVVVPDQLVDRTSGRADTYFDFGGV-H 126
Query: 123 VSMADPFCPELRRIFIETAKELGLP-VHEKGTYICIEGPRFSTRAESRMFRQF-ADVIGM 180
+ ADP+CP LR A GLP V + GT + I+GPRFSTRAES+ F +++ M
Sbjct: 127 AAFADPYCPTLR------AAVTGLPGVVDGGTMVVIQGPRFSTRAESQWFAAAGCNLVNM 180
Query: 181 TLVPEVNLARELGMCYVNISTVTDYD--VWAEKPVNAQEVLRVMKENEEKVQKLLRKAIP 238
T PE LAREL +CY I+ VTD D V A V A +V EN E +++L+R AI
Sbjct: 181 TGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAADVFAAFGENIELLKRLVRAAID 240
Query: 239 KIPEERKC 246
++ +ER C
Sbjct: 241 RVADERTC 248
>pir||A69080 methylthioadenosine phosphorylase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622720|gb|AAB86069.1| (AE000919)
methylthioadenosine phosphorylase [Methanobacterium
thermoautotrophicum]
Length = 280
Score = 194 bits (489), Expect = 7e-49
Identities = 110/255 (43%), Positives = 150/255 (58%), Gaps = 12/255 (4%)
Query: 4 IGIIGGSGVYGVFEPKEVVK---IHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
IGIIGG+G+Y + E + + + TPYG+ + + + ++ G VAFIPRH H+ PPH
Sbjct: 2 IGIIGGTGIYEMAEYGRLERRGSLITPYGK-TPEISVFKLHGRRVAFIPRHSPGHDKPPH 60
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKV 120
V YRANIWAL ELGV +IIA NAVGSLK PGD V+ F+DFT+ R TFY+ K
Sbjct: 61 MVNYRANIWALKELGVRQIIATNAVGSLKRSIGPGDFVVPHDFLDFTRSRPSTFYD-EKT 119
Query: 121 AHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQF-ADVIG 179
HV M +P+C +R +A V + G Y+C EGPRF T AE RMF+ V+G
Sbjct: 120 VHVDMTEPYCRNIR-----SALSGSSGVVDGGVYVCTEGPRFETPAEIRMFQTLGGTVVG 174
Query: 180 MTLVPEVNLARELGMCYVNISTVTDYDV-WAEKPVNAQEVLRVMKENEEKVQKLLRKAIP 238
MT +PE LAREL MCY +I V++Y + + EV +M E + + ++ AI
Sbjct: 175 MTGLPEAVLARELEMCYASICLVSNYAASISPSKLTIDEVFEIMDEKKNDLIDIIDAAIR 234
Query: 239 KIPEERKCGCADVLK 253
+ E+ C C L+
Sbjct: 235 DLKTEQSCPCQHALR 249
>pir||S76441 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1653658|dbj|BAA18570.1| (D90915) hypothetical
protein [Synechocystis sp.]
Length = 326
Score = 194 bits (488), Expect = 9e-49
Identities = 103/245 (42%), Positives = 154/245 (62%), Gaps = 8/245 (3%)
Query: 4 IGIIGGSGVYGVFEPKEV--VKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHE 61
IGIIGGSG+Y + K V V + TP+G PS +GE+ GV VAF+ RHG+ H P E
Sbjct: 38 IGIIGGSGLYQMEALKNVEEVTLDTPFGAPSDSFIVGELAGVRVAFLARHGRGHHLLPSE 97
Query: 62 VPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVA 121
+P+RANI + +LGV+ +I+ +AVGSL+ E KP D+V+ DQFID T++R TF+ VA
Sbjct: 98 IPFRANIHGMKQLGVKYLISASAVGSLQAEAKPLDMVVPDQFIDRTRQRISTFFGEGIVA 157
Query: 122 HVSMADPFCPELRRIFIETAKEL---GLPVHEKGTYICIEGPRFSTRAESRMFRQF-ADV 177
H+ +P CP+L + L G+ +H++GTY+ +EGP FST AES ++R + V
Sbjct: 158 HIGFGNPICPQLAQCLSTAIAGLELEGVTLHDRGTYVSMEGPAFSTIAESNLYRSWGGTV 217
Query: 178 IGMTLVPEVNLARELGMCYVNISTVTDYDVW--AEKPVNAQEVLRVMKENEEKVQKLLRK 235
IGMT +PE LARE + Y ++ VTDYD W V + V+ +++N Q+++ +
Sbjct: 218 IGMTNLPEAKLAREAEIAYATLALVTDYDCWHPDHDHVTVEMVIGNLQKNAVNAQQVILE 277
Query: 236 AIPKI 240
+ ++
Sbjct: 278 TVKQL 282
>emb|CAB75631.1| (AL157415) 5'-methylthioadenosine phosphorylase [Leishmania major]
Length = 306
Score = 190 bits (478), Expect = 1e-47
Identities = 105/241 (43%), Positives = 145/241 (59%), Gaps = 13/241 (5%)
Query: 4 IGIIGGSGVYGVFEPKEVV--KIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHE 61
I +IGGSGVY + ++ V + TPYG PS + + +++GV F+PRHG +H++ P E
Sbjct: 12 IAVIGGSGVYKLNCLQDAVYHDVPTPYGNPSGQLCVAKVDGVPCVFLPRHGPHHQYNPSE 71
Query: 62 VPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVA 121
+ YRANI AL ++GV I+AINAVGSL E YKPGD+V+ DQ ID T R+ TF+ V
Sbjct: 72 INYRANICALKQMGVRYILAINAVGSLDESYKPGDLVLCDQIIDKTYMRKATFFEDGVVV 131
Query: 122 HVSMADPFC--------PELRRIFIETAKELG-LPVHEKGTYICIEGPRFSTRAESRMFR 172
H A P L R F + A G +H GT + +EGP+FST+AES + +
Sbjct: 132 HADFAHPTSRIFNSIVHEALLRCFPDVAAGKGTFQIHSSGTLVTMEGPQFSTKAESLLNK 191
Query: 173 QF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKP-VNAQEVLRVMKENEEKVQ 230
Q +IGMT E LARE + Y ++ VTD D W++ P V+A +V +VM N EK Q
Sbjct: 192 QMGGHLIGMTSATEARLAREAEIAYATVAMVTDMDAWSDAPHVDAAQVTKVMAANVEKAQ 251
Query: 231 K 231
+
Sbjct: 252 R 252
>sp|Q09438|MTAP_CAEEL PUTATIVE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE (MTA PHOSPHORYLASE)
>gi|7494774|pir||T29047 hypothetical protein B0228.7 -
Caenorhabditis elegans >gi|726367|gb|AAC38810.1|
(U23168) similar to hypothetical 25.8 kd protein in PETC
3' region in R. rubrum (SP:YPE2_RHORU, P23139)
[Caenorhabditis elegans]
Length = 285
Score = 187 bits (471), Expect = 9e-47
Identities = 105/249 (42%), Positives = 148/249 (59%), Gaps = 12/249 (4%)
Query: 1 MPKIGIIGGSGVY--GVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFP 58
M K+GIIGGSG+ + V + TPYG+PS V G I GVE + RHG+ H+
Sbjct: 1 MVKVGIIGGSGLEDPNILLDPVTVAVDTPYGKPSDDVVEGTINGVECVLLARHGRKHDIM 60
Query: 59 PHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNG- 117
P V +RAN+WALY GV+ IIA A GSL+E +PG ++ D T R+ TF++G
Sbjct: 61 PGNVNFRANLWALYSRGVDVIIASTACGSLQENVEPGHLLFPD---SVTTGRQSTFFDGS 117
Query: 118 ----PKVAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESRMFRQ 173
P V H+ + +LR++ I TA+ L H G +CIEGPRFST+AES +F+
Sbjct: 118 YDQAPGVCHIQAHPTYNEKLRQVLISTAERCQLVHHRTGFGVCIEGPRFSTKAESMVFKS 177
Query: 174 F-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKP-VNAQEVLRVMKENEEKVQK 231
+ A ++ MT++PE LA+ELG+ Y + VTDYD W E+ V A V++V N EK +
Sbjct: 178 WGASLVNMTMMPECILAKELGIPYATTALVTDYDCWKEEDHVTASSVMKVFAANVEKAKT 237
Query: 232 LLRKAIPKI 240
L +A+ +I
Sbjct: 238 LFVEAVGEI 246
>sp|Q09816|YAC2_SCHPO HYPOTHETICAL 33.9 KD PROTEIN C16C9.02C IN CHROMOSOME I
>gi|2130279|pir||S62472 probable Methylthioadenosine
phosphorylase - fission yeast (Schizosaccharomyces
pombe) >gi|1019814|emb|CAA91190.1| (Z54366) putative
Methylthioadenosine phosphorylase [Schizosaccharomyces
pombe]
Length = 307
Score = 172 bits (431), Expect = 4e-42
Identities = 103/251 (41%), Positives = 144/251 (57%), Gaps = 14/251 (5%)
Query: 4 IGIIGGSGVYGV--FEPKEVVKIHTPYGRPSAPVEIGEI-EGVEVAFIPRHGKYHEFPPH 60
+G+IGGSG Y + F+ E V TP+G P++P+ I G +AF+ RHG H + P
Sbjct: 10 LGVIGGSGFYDLPGFDIVESVNPITPWGYPASPISIARTTSGFLIAFLARHGVGHIYTPT 69
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTK-KREYTFYNGPK 119
EVP RANI AL LGV I++ +AVGSL+E+ P D V+ Q ID T R TF+
Sbjct: 70 EVPSRANIAALKSLGVLAIVSFSAVGSLREDIPPEDFVLPTQIIDRTLCARPNTFFESGC 129
Query: 120 VAHVSMADPFCPELRRIFIETAKEL--GLPVHEKG-----TYICIEGPRFSTRAESRMFR 172
VAHVS DPF +L I L G +H K T +C+EGP FSTRAES ++R
Sbjct: 130 VAHVSFGDPFDQDLYEILSSCGSNLKNGSKLHTKRKGDDLTVVCMEGPAFSTRAESNLYR 189
Query: 173 QF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWA--EKPVNAQEVLRVMKENEEKV 229
+ A +I M+++PE LARE + Y + TDYD W E+PV + V+ + N++
Sbjct: 190 SWGASIINMSVIPEAKLAREAEIAYQMVCMATDYDCWRMNEEPVTVETVMEHISNNKDNA 249
Query: 230 QKLLRKAIPKI 240
+ L +A+ K+
Sbjct: 250 KIFLLEAVKKL 260
>pir||F83270 probable nucleoside phosphorylase PA3004 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9949105|gb|AAG06392.1|AE004725_5 (AE004725) probable
nucleoside phosphorylase [Pseudomonas aeruginosa]
Length = 245
Score = 165 bits (413), Expect = 6e-40
Identities = 92/243 (37%), Positives = 136/243 (55%), Gaps = 6/243 (2%)
Query: 1 MPKIGIIGGSGVYGV--FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFP 58
M IIGG+G+ + E + I TPYG PSAP++ G G EV F+ RHG H FP
Sbjct: 1 MSVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHPHRFP 60
Query: 59 PHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNG- 117
PH+V YRAN+WAL + G E +IA+NAVG + G + + Q ID+T RE+T++ G
Sbjct: 61 PHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGD 120
Query: 118 -PKVAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAE-SRMFRQFA 175
V H+ + P+ LR+ IE + LGL G Y C +GPR T AE +R+ R
Sbjct: 121 IEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGN 180
Query: 176 DVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKP-VNAQEVLRVMKENEEKVQKLLR 234
D++GMT +PE LAREL + Y ++ V + + E+ + + + KV+++L
Sbjct: 181 DIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLA 240
Query: 235 KAI 237
+ +
Sbjct: 241 RVL 243
>pir||H82568 purine nucleoside phosphorylase XF2353 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107527|gb|AAF85152.1|AE004045_10 (AE004045) purine
nucleoside phosphorylase [Xylella fastidiosa]
Length = 237
Score = 162 bits (406), Expect = 4e-39
Identities = 85/207 (41%), Positives = 126/207 (60%), Gaps = 5/207 (2%)
Query: 4 IGIIGGSGVYGV--FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHE 61
+ +IGG+GVY + + +V ++ T YGRPS P+ +G + G VAF RHG+ H PPH+
Sbjct: 6 LAVIGGTGVYTLSQLDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHALPPHK 65
Query: 62 VPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYN--GPK 119
+ YRANI AL +LGV R++A+N VG + E + P +V DQ ID+T R TF G +
Sbjct: 66 INYRANIAALQQLGVSRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCEEVGSE 125
Query: 120 VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAE-SRMFRQFADVI 178
V HV P+ P LR + A+++ + + E G Y +GPR T AE +R+ R D++
Sbjct: 126 VLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCYGVTQGPRLETIAEIARLRRDGCDLV 185
Query: 179 GMTLVPEVNLARELGMCYVNISTVTDY 205
GMT +PE LARE G+ Y + V+++
Sbjct: 186 GMTGMPEAALAREKGLEYACLGIVSNW 212
>gi|11499377 methylthioadenosine phosphorylase (mtaP) [Archaeoglobus fulgidus]
>gi|7450061|pir||C69473 methylthioadenosine
phosphorylase (mtaP) homolog - Archaeoglobus fulgidus
>gi|2648757|gb|AAB89459.1| (AE000979)
methylthioadenosine phosphorylase (mtaP) [Archaeoglobus
fulgidus]
Length = 243
Score = 160 bits (401), Expect = 1e-38
Identities = 90/245 (36%), Positives = 146/245 (58%), Gaps = 11/245 (4%)
Query: 4 IGIIGGSGVYGVFEPKEV--VKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHE 61
IGIIGG+ + + K+V +I TPYG +A +++G ++G++VA I RHGK + PPH
Sbjct: 2 IGIIGGTHILEIKVLKDVEETRIETPYG--TAEIDVGRVDGIDVAIIQRHGKRKDKPPHR 59
Query: 62 VPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVA 121
+ + AN +AL LGV+ +I + +VG+L+EEY ++I +IDF T YN +
Sbjct: 60 INHAANFYALKSLGVKYVIGMGSVGALREEYSLPSLIIPHDYIDFFS--GVTIYN-DSLV 116
Query: 122 HVSMADPFCPELRRIFIETAKEL-GLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM 180
HV+ F LR + +E A+++ PV +KG Y GPR T+AE M + FAD +GM
Sbjct: 117 HVTPG--FDEYLREVLVEVARKISSFPVIDKGVYFQTRGPRLETKAEIAMIKSFADCVGM 174
Query: 181 TLVPEVNLARELGMCYVNISTVTDYDVWAE-KPVNAQEVLRVMKENEEKVQKLLRKAIPK 239
T E +ARELG+ Y + T+ +Y + + ++ +E++ KEN + K++ +A+ K
Sbjct: 175 TAGSEATIARELGLSYAIVCTMDNYAHGIKNQSIDYREIVEKAKENARECLKIVEEAVKK 234
Query: 240 IPEER 244
+ EE+
Sbjct: 235 VWEEK 239
>emb|CAA62156.1| (X90564) orf [Saccharomyces cerevisiae]
Length = 337
Score = 160 bits (400), Expect = 2e-38
Identities = 99/261 (37%), Positives = 142/261 (53%), Gaps = 21/261 (8%)
Query: 4 IGIIGGSGVYGV--FEPKEVVK-IHTPYGRPSAPVEIGEIEGVE----VAFIPRHGKYHE 56
+GIIGG+G+Y + EP +V + TP+G S+PV I + G VAFI RHG HE
Sbjct: 35 LGIIGGTGLYNLDCLEPIALVPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGINHE 94
Query: 57 FPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYN 116
+PP +VP+RAN+ AL L + +++ +AVGSL+ KP D V+ Q ID TK ++ Y
Sbjct: 95 YPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYF 154
Query: 117 GPK--VAHVSMADPFCPELRRIFIETAKELGLPVHEKG---------TYICIEGPRFSTR 165
+ V HV PF + + E+ P E+ T +C+EGP+FSTR
Sbjct: 155 NDEGLVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTR 214
Query: 166 AESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAE--KPVNAQEVLRVM 222
AES+M+R F VI M+++PE LARE + Y I TDYD W + +PV + V+ +
Sbjct: 215 AESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTVETVIGNL 274
Query: 223 KENEEKVQKLLRKAIPKIPEE 243
N L K I + +E
Sbjct: 275 TNNGRNANILASKIIVSMAKE 295
>gi|6323045 regulator of ADH2 expression; Meu1p [Saccharomyces cerevisiae]
>gi|2494054|sp|Q07938|YL17_YEAST HYPOTHETICAL 37.9 KD
PROTEIN IN PPR1-SNF7 INTERGENIC REGION
>gi|2131750|pir||S64839 hypothetical protein YLR017w -
yeast (Saccharomyces cerevisiae)
>gi|1360318|emb|CAA97539.1| (Z73189) ORF YLR017w
[Saccharomyces cerevisiae]
Length = 337
Score = 159 bits (397), Expect = 4e-38
Identities = 98/261 (37%), Positives = 142/261 (53%), Gaps = 21/261 (8%)
Query: 4 IGIIGGSGVYGV--FEPKEVVK-IHTPYGRPSAPVEIGEIEGVE----VAFIPRHGKYHE 56
+GIIGG+G+Y + EP ++ + TP+G S+PV I + G VAFI RHG HE
Sbjct: 35 LGIIGGTGLYNLDCLEPIALLPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGINHE 94
Query: 57 FPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYN 116
+PP +VP+RAN+ AL L + +++ +AVGSL+ KP D V+ Q ID TK ++ Y
Sbjct: 95 YPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYF 154
Query: 117 GPK--VAHVSMADPFCPELRRIFIETAKELGLPVHEKG---------TYICIEGPRFSTR 165
+ V HV PF + + E+ P E+ T +C+EGP+FSTR
Sbjct: 155 NDEGLVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTR 214
Query: 166 AESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAE--KPVNAQEVLRVM 222
AES+M+R F VI M+++PE LARE + Y I TDYD W + +PV + V+ +
Sbjct: 215 AESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTVETVIGNL 274
Query: 223 KENEEKVQKLLRKAIPKIPEE 243
N L K I + +E
Sbjct: 275 TNNGRNANILASKIIVSMAKE 295
>pir||H72217 purine nucleoside phosphorylase - Thermotoga maritima (strain
MSB8) >gi|4982314|gb|AAD36802.1|AE001812_12 (AE001812)
purine nucleoside phosphorylase [Thermotoga maritima]
Length = 299
Score = 108 bits (266), Expect = 1e-22
Identities = 84/259 (32%), Positives = 133/259 (50%), Gaps = 25/259 (9%)
Query: 2 PKIGIIGGSGVYGVFEP--KEVVKIHTPYGR-PSAPVE----------IGEIEGVEVAFI 48
P+I II GSG+ + + KE PY P P+ G++ G V +
Sbjct: 46 PEIAIILGSGLSVIADEVEKEGTSKKIPYSEIPGFPISTAPGHKGELIFGKLFGKNVMLM 105
Query: 49 PRHGKYHE-FPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFT 107
Y+E + EV + + L LGVE +I NA G L +++ G +II I+F
Sbjct: 106 NGRFHYYEGYSMKEVTFPIRVMQL--LGVEILIVTNAAGGLNPDFEVGRPMIITDHINFM 163
Query: 108 KKREYTFYN----GPKVAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFS 163
N GP+ M++P+ EL + +A+ELG+PV++ G Y+ + GP F
Sbjct: 164 GDNPLIGPNVDEWGPRFP--DMSEPYDKELIELAYNSARELGIPVYQ-GVYVAVTGPCFE 220
Query: 164 TRAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAE-KPVNAQEVLRV 221
T AE RM R+F AD +GM+ VPEV +AR + + IS +TD V + KP+ A+EVL V
Sbjct: 221 TPAELRMLRKFGADAVGMSTVPEVIVARHGQIRVLGISAITDRAVPEDLKPLTAEEVLEV 280
Query: 222 MKENEEKVQKLLRKAIPKI 240
++ K+ +++ + + K+
Sbjct: 281 AEKTGRKIAQIIFEVVRKL 299
>dbj|BAB05251.1| (AP001512) purine nucleoside phosphorylase [Bacillus halodurans]
Length = 275
Score = 107 bits (265), Expect = 1e-22
Identities = 83/257 (32%), Positives = 125/257 (48%), Gaps = 24/257 (9%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGR-PSAPVEIGEIEGVEVAFIPRHGK------- 53
P IG+I GSG+ G + +H PY + P+ PV E ++ HGK
Sbjct: 23 PAIGLILGSGL-GELANEIEEAVHIPYEQIPNFPVSTVEGHAGQLVIGTLHGKNVVAMQG 81
Query: 54 ----YHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKK 109
Y + EV + + + E+GVE I+ NA G + + + PGD++II ++ T
Sbjct: 82 RFHYYEGYTMQEVTFPVRV--MKEIGVELIVVTNACGGMNKNFAPGDLMIITDHLNMTGD 139
Query: 110 REYTFYN----GPKVAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTR 165
N GP+ +S A + PEL ETA L + V +KG Y I GP + T
Sbjct: 140 NPLIGPNVEEWGPRFPDMSHA--YTPELVEFVEETANRLDIKV-QKGVYAGITGPTYMTG 196
Query: 166 AESRMFRQFA-DVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAE-KPVNAQEVLRVMK 223
AE M R DVIGM+ VPEV +AR GM + IS +TD + E + +EV+ V
Sbjct: 197 AELIMLRNLGGDVIGMSTVPEVIVARHAGMKVIGISCITDMAIGEEIAGITHEEVVAVAN 256
Query: 224 ENEEKVQKLLRKAIPKI 240
+ + K KL+++ + +
Sbjct: 257 KTKPKFIKLVKEIVANV 273
>sp|P23139|YPE2_RHORU HYPOTHETICAL 25.8 KD PROTEIN IN PETC 3'REGION >gi|79576|pir||S12259
hypothetical protein 2 (petC 3' region) - Rhodospirillum
rubrum >gi|46387|emb|CAA39061.1| (X55387) ORF2
[Rhodospirillum rubrum]
Length = 238
Score = 106 bits (261), Expect = 4e-22
Identities = 54/116 (46%), Positives = 75/116 (64%), Gaps = 2/116 (1%)
Query: 2 PKIGIIGGSGVYGV--FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPP 59
P +G+IGGSGVY + E + +P+G S + G ++G+E+AF+PRHG+ H P
Sbjct: 8 PVLGVIGGSGVYDIDGLEGARWQTVESPFGDVSDQILRGTLDGLEMAFLPRHGRGHVLAP 67
Query: 60 HEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFY 115
+V YRANI AL GV I++++AVGSL E+ PG VI DQFID T RE +F+
Sbjct: 68 SDVNYRANIDALKRAGVTEILSVSAVGSLAEDLPPGTFVIADQFIDRTFAREKSFF 123
>gb|AAD19641.1| (AF109294) hypothetical methylthioadenosine phosphorylase fusion
protein [Homo sapiens]
Length = 143
Score = 104 bits (258), Expect = 9e-22
Identities = 56/120 (46%), Positives = 75/120 (61%), Gaps = 10/120 (8%)
Query: 3 KIGIIGGSGVYG--VFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
KIGIIGG+G+ + E + + TP+G+PS + +G+I+ V+ + RHG+ H P
Sbjct: 11 KIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCILLARHGRQHTIMPS 70
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFT--------KKREY 112
+V Y+ANIWAL E G +I A GSL+EE +PGDIVIIDQFID T KREY
Sbjct: 71 KVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTICHDISKDSKREY 130
>emb|CAB61871.1| (AL133252) putative phosphorylase [Streptomyces coelicolor A3(2)]
Length = 262
Score = 101 bits (249), Expect = 1e-20
Identities = 76/249 (30%), Positives = 116/249 (46%), Gaps = 13/249 (5%)
Query: 3 KIGIIGGSGVYGV--FEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH 60
+IG+I GSG Y E + T +G + V G + G E+ + RHG H
Sbjct: 2 RIGVITGSGSYDWPHLEGAAERTVVTEHG--AVTVTEGRLGGAEIVQLSRHGTGHHRLSS 59
Query: 61 EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFI-------DFTKKREYT 113
+V ++AN+ AL + E +++ GSL+ + +PG +V+ D D T Y
Sbjct: 60 QVDHKANLAALLAVEAEAVVSFTVCGSLEPDVRPGSLVVFDDLYFPANRLPDGTPCTWYD 119
Query: 114 FYNGPKVAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAE-SRMFR 172
G H PF LR+ I A + G+PV +G Y ++GPRF+TR E + +
Sbjct: 120 TPGGAGRGHWIFDRPFSEPLRQALITAADQTGVPVATQGVYGHVDGPRFNTRPEVAALAA 179
Query: 173 QFADVIGMTLVPEVNLARELGMCYVNISTVTDY-DVWAEKPVNAQEVLRVMKENEEKVQK 231
I T PEV LA E + V + VTDY + A +P Q +L M +++ K
Sbjct: 180 AGVSAISQTAGPEVVLAGEAELPMVLVGFVTDYANGVAPEPEPVQALLDRMAASKDVFAK 239
Query: 232 LLRKAIPKI 240
L A+P +
Sbjct: 240 LAEHALPSL 248
>sp|P77834|PUNA_BACST PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (PU-NPASE I) (INOSINE
PHOSPHORYLASE) >gi|2126870|pir||JT0873 purine-nucleoside
phosphorylase (EC 2.4.2.1) - Bacillus stearothermophilus
>gi|1638804|dbj|BAA13509.1| (D87959) purine nucleoside
phosphorylase [Bacillus stearothermophilus]
Length = 274
Score = 94.4 bits (231), Expect = 1e-18
Identities = 79/247 (31%), Positives = 119/247 (47%), Gaps = 28/247 (11%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGR-PSAPVEI----------GEIEGVEVAFIPR 50
P+IG+I GSG+ GV + I PY P+ PV G++EG V +
Sbjct: 21 PQIGLILGSGL-GVLADEIEQAIKIPYSDIPNFPVSTVEGHAGQLVYGQLEGATVVVMQG 79
Query: 51 HGKYHE---FPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFT 107
Y+E F P R + LGVE++I NA G + E ++PGD++II I+
Sbjct: 80 RFHYYEGYSFDKVTFPVRV----MKALGVEQLIVTNAAGGVNESFEPGDLMIISDHINNM 135
Query: 108 KKREYTFYNGPK--VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTR 165
N V M++ + LR++ + A ++GL V E G Y+ GP + T
Sbjct: 136 GGNPLIGPNDSALGVRFPDMSEAYSKRLRQLAKDVANDIGLRVRE-GVYVANTGPAYETP 194
Query: 166 AESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRVMK 223
AE RM R D +GM+ VPEV +AR GM + IS +++ ++P+ EV+
Sbjct: 195 AEIRMIRVMGGDAVGMSTVPEVIVARHAGMEVLGISCISNMAAGILDQPLTHDEVI---- 250
Query: 224 ENEEKVQ 230
E EKV+
Sbjct: 251 ETTEKVK 257
>sp|P46354|PUNA_BACSU PURINE NUCLEOSIDE PHOSPHORYLASE I (PNP I) (PU-NPASE I) (INOSINE
PHOSPHORYLASE) >gi|7433916|pir||D69680 purine-nucleoside
phosphorylase (EC 2.4.2.1) pnp - Bacillus subtilis
>gi|944944|gb|AAA74434.1| (U32685) purine nucleoside
phosphorylase [Bacillus subtilis]
>gi|1303996|dbj|BAA12651.1| (D84432) YqkO [Bacillus
subtilis] >gi|2634784|emb|CAB14281.1| (Z99116) purine
nucleoside phosphorylase [Bacillus subtilis]
Length = 271
Score = 91.3 bits (223), Expect = 1e-17
Identities = 73/255 (28%), Positives = 124/255 (48%), Gaps = 26/255 (10%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGR-PSAPVE----------IGEIEGVEVAFIPR 50
PKIG+I GSG+ G+ + + Y P PV +G +EGV V I
Sbjct: 20 PKIGLILGSGL-GILADEIENPVKLKYEDIPEFPVSTVEGHAGQLVLGTLEGVSV--IAM 76
Query: 51 HGKYHEFPPHEVP-YRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKK 109
G++H + + + + + LGVE +I NA G + E++ GD++II I+F
Sbjct: 77 QGRFHFYEGYSMEKVTFPVRVMKALGVEALIVTNAAGGVNTEFRAGDLMIITDHINFMGT 136
Query: 110 REYTFYNGPKVAHV-----SMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFST 164
GP A M+ + +L + + AK+L +P+ +KG Y + GP + T
Sbjct: 137 NPLI---GPNEADFGARFPDMSSAYDKDLSSLAEKIAKDLNIPI-QKGVYTAVTGPSYET 192
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRVM 222
AE R R +D +GM+ VPEV +A GM + IS +++ ++P++ EV+ V
Sbjct: 193 PAEVRFLRTMGSDAVGMSTVPEVIVANHAGMRVLGISCISNAAAGILDQPLSHDEVMEVT 252
Query: 223 KENEEKVQKLLRKAI 237
++ + KL++ +
Sbjct: 253 EKVKAGFLKLVKAIV 267
>pdb|1FXU|A Chain A, Purine Nucleoside Phosphorylase From Calf Spleen In
Complex With N(7)-Acycloguanosine Inhibitor And A
Phosphate Ion
Length = 289
Score = 88.2 bits (215), Expect = 9e-17
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSLLMASIP 283
>pdb|1PBN| Purine Nucleoside Phosphorylase >gi|4699623|pdb|4PNP| The High
Resolution Crystal Structure Of Bovine Spleen Purine
Nucleoside Phosphorylase In Complex Forms With Phosphate
And 9-Deazainosine >gi|4699622|pdb|3PNP| The High
Resolution Crystal Structure Of Bovine Spleen Purine
Nucleoside Phosphorylase In Complex Forms With Phosphate
And 9-Deazainosine
Length = 289
Score = 87.8 bits (214), Expect = 1e-16
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSLLMASIP 283
>pdb|1VFN| Purine Nucleoside Phosphorylase
Length = 281
Score = 87.8 bits (214), Expect = 1e-16
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 22 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 81
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 82 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 139
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 140 GQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 199
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 200 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLE 259
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 260 AGKQAAQKLEQFVSLLMASIP 280
>pdb|1A9T| Bovine Purine Nucleoside Phosphorylase Complexed With
9-Deazainosine And Phosphate
Length = 284
Score = 87.8 bits (214), Expect = 1e-16
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSLLMASIP 283
>pdb|1A9P| Bovine Purine Nucleoside Phosphorylase Complexed With
9-Deazainosine And Phosphate >gi|3402089|pdb|1A9O|
Bovine Purine Nucleoside Phosphorylase Complexed With
Phosphate >gi|3402093|pdb|1A9S| Bovine Purine
Nucleoside Phosphorylase Complexed With Inosine And
Sulfate
Length = 289
Score = 87.8 bits (214), Expect = 1e-16
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSLLMASIP 283
>pir||S66203 purine-nucleoside phosphorylase (EC 2.4.2.1) - bovine
>gi|1042206|gb|AAB34886.1| purine nucleoside
phosphorylase, PNP, purine nucleoside:orthophosphate
ribosyltransferase {EC 2.4.2.1} [cattle, spleen,
Peptide, 284 aa] >gi|1580938|prf||2116271A purine
nucleoside phosphorylase [Bos taurus]
Length = 284
Score = 87.4 bits (213), Expect = 2e-16
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSLLMASIP 283
>sp|P55859|PNPH_BOVIN PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
Length = 289
Score = 87.4 bits (213), Expect = 2e-16
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSLLMASIP 283
>pdb|1B8O|A Chain A, Purine Nucleoside Phosphorylase >gi|4558113|pdb|1B8N|A
Chain A, Purine Nucleoside Phosphorylase
Length = 284
Score = 87.4 bits (213), Expect = 2e-16
Identities = 70/261 (26%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSLLMASIP 283
>pir||T37901 probable purine nucleoside phosphorylase - fission yeast
(Schizosaccharomyces pombe) >gi|5912369|emb|CAB55857.1|
(AL117390) putative purine nucleoside phosphorylase
[Schizosaccharomyces pombe]
Length = 315
Score = 86.6 bits (211), Expect = 3e-16
Identities = 72/249 (28%), Positives = 114/249 (44%), Gaps = 40/249 (16%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAFIPRH---------- 51
PK+ II GSG+ + PY +I V+ +P H
Sbjct: 41 PKVAIICGSGLGTLASGLSAPVYEVPYE---------DIPHFHVSHVPGHASKLYFAFLG 91
Query: 52 ----------GKYHEFPPHEVPYRA-NIWALYELGVERIIAINAVGSLKEEYKPGDIVII 100
G+YH + + + + + +GVE ++ NA G L + +K GD++I+
Sbjct: 92 EKRVPTMILAGRYHSYEGYPIEATTFPVRLMKVMGVEVMVVTNAAGGLNQGFKVGDLMIL 151
Query: 101 DQFIDFTKKREYTFYNGPK-----VAHVSMADPFCPELRRIFIETAK--ELGLPVHEKGT 153
I+F GP V ++D + ELR++ + AK ++ +HE G
Sbjct: 152 KDHINFPGLAGMNPLRGPNAHEFGVRFPPLSDAYDLELRKLVYDAAKAHKVSRTIHE-GC 210
Query: 154 YICIEGPRFSTRAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKP 212
Y + GP F TRAESRM AD +GM+ VPEV +AR G+ + IS VT+ V E P
Sbjct: 211 YAFVSGPCFETRAESRMLALMGADCVGMSTVPEVVVARHCGIRVLAISLVTNNVVVEESP 270
Query: 213 VNAQEVLRV 221
+A++++ V
Sbjct: 271 -SAKDLVEV 278
>gi|4557801 purine nucleoside phosphorylase [Homo sapiens]
>gi|130377|sp|P00491|PNPH_HUMAN PURINE NUCLEOSIDE
PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|66583|pir||PHHUPN purine-nucleoside phosphorylase
(EC 2.4.2.1) [validated] - human >gi|230388|pdb|1ULB|
Purine Nucleoside Phosphorylase (E.C.2.4.2.1) Complex
With Guanine >gi|230387|pdb|1ULA| Purine Nucleoside
Phosphorylase (E.C.2.4.2.1) >gi|35565|emb|CAA25320.1|
(X00737) PNP [Homo sapiens]
Length = 289
Score = 85.8 bits (209), Expect = 5e-16
Identities = 69/261 (26%), Positives = 124/261 (47%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ II GSG+ G+ + +I P+ P + G + G + R
Sbjct: 25 PQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGV+ ++ NA G L +++ GDI++I I+
Sbjct: 85 FHMYEGYPLWKVTFPVRVFHL--LGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPKVAHV-----SMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP +M+D + +R+ + T K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ ++ AD +GM+ VPEV +AR G+ S +T+ D + + N +EVL
Sbjct: 203 VAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLA 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSILMASIP 283
>gb|AAA36460.1| (M13953) purine nucleoside phosphorylase [Homo sapiens]
Length = 289
Score = 85.8 bits (209), Expect = 5e-16
Identities = 69/261 (26%), Positives = 124/261 (47%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ II GSG+ G+ + +I P+ P + G + G + R
Sbjct: 25 PQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGV+ ++ NA G L +++ GDI++I I+
Sbjct: 85 FHMYRGYPLWKVTFPVRVFHL--LGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPKVAHV-----SMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP +M+D + +R+ + T K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ ++ AD +GM+ VPEV +AR G+ S +T+ D + + N +EVL
Sbjct: 203 VAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLA 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSILMASIP 283
>gi|11437430 purine nucleoside phosphorylase [Homo sapiens]
Length = 289
Score = 85.4 bits (208), Expect = 6e-16
Identities = 68/261 (26%), Positives = 125/261 (47%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAF--------IPRHGK 53
P++ II GSG+ G+ + +I P+ P+ + F + G+
Sbjct: 25 PQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPLYTVPGHAGRLVFGFLNGRACVMMQGR 84
Query: 54 YHEF---PPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
+H + P +V + ++ L LGV+ ++ NA G L +++ GDI++I I+
Sbjct: 85 FHMYEGYPLWKVTFPVRVFHL--LGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPKVAHV-----SMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP +M+D + +R+ + T K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ ++ AD +GM+ VPEV +AR G+ S +T+ D + + N +EVL
Sbjct: 203 VAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLA 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K+ +K+++ + + IP
Sbjct: 263 AGKQAAQKLEQFVSILMASIP 283
>pdb|1A9Q| Bovine Purine Nucleoside Phosphorylase Complexed With Inosine
>gi|3402092|pdb|1A9R| Bovine Purine Nucleoside
Phosphorylase Complexed With Hypoxanthine And Sulfate
Length = 282
Score = 85.0 bits (207), Expect = 8e-16
Identities = 68/253 (26%), Positives = 118/253 (45%), Gaps = 23/253 (9%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAP----------VEIGEIEGVEVAFIP-R 50
P++ +I GSG+ G+ + P+ P + G + G + R
Sbjct: 25 PQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGR 84
Query: 51 HGKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
Y +P +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYPFWKVTFPVRVFRL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFS 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ T K++G ++GTY+ + GP F T
Sbjct: 143 GENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AE R+ R AD +GM+ VPEV +AR G+ S +T+ D ++ N +EVL
Sbjct: 203 VAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLE 262
Query: 221 VMKENEEKVQKLL 233
K+ +K+++ +
Sbjct: 263 AGKQAAQKLEQFV 275
>dbj|BAB05250.1| (AP001512) purine nucleoside phosphorylase [Bacillus halodurans]
Length = 272
Score = 85.0 bits (207), Expect = 8e-16
Identities = 75/254 (29%), Positives = 120/254 (46%), Gaps = 21/254 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGR-PSAPVE----------IGEIEGVEVAFIPR 50
P IG+I GSG+ G+ + + PY P PV IG +EG +V I
Sbjct: 22 PTIGLILGSGL-GILADEIEQPVKVPYSDIPHFPVSTVQGHAGQLVIGMLEGKQV--IAM 78
Query: 51 HGKYHEFPPHEVPYRA-NIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKK 109
G++H + + + + + LGVE+II NA G + E ++ GD++II I+ +
Sbjct: 79 QGRFHFYEGYSLEVVTFPVRVMKALGVEQIIVTNAAGGVNESFEAGDLMIIRDHINNMAQ 138
Query: 110 REYTFYNGPK--VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAE 167
N V M++ + LR + E L L + E G Y+ GP + T AE
Sbjct: 139 NPLIGPNDEAFGVRFPDMSNAYSERLRTLAKEKGNTLNLKLQE-GVYVANTGPVYETPAE 197
Query: 168 SRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRVMKEN 225
RM R+ D +GM+ VPEV +AR G+ + IS +++ +P++ EV+ +
Sbjct: 198 VRMIRKLGGDAVGMSTVPEVIVARHAGLEVLGISCISNMAAGILPQPLSHDEVIETTERV 257
Query: 226 EEKVQKLLRKAIPK 239
+ L+ KAI K
Sbjct: 258 RQDFLNLV-KAIVK 270
>gi|7305395 purine-nucleoside phopshorylase [Mus musculus]
>gi|53750|emb|CAA39888.1| (X56548) purine-nucleoside
phosphorylase [Mus musculus] >gi|1144567|gb|AAB60510.1|
(U35374) purine nucleoside phosphorylase [Mus musculus]
Length = 289
Score = 81.1 bits (197), Expect = 1e-14
Identities = 67/261 (25%), Positives = 120/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAF--------IPRHGK 53
P++ +I GSG+ G+ + +I P+ P + + F + G+
Sbjct: 25 PQVAVICGSGLGGLTAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMMQGR 84
Query: 54 YHEFPPH---EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
+H + + +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFC 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFSAWKQMGEQRKLQEGTYVMLAGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AESR+ + AD +GM+ VPEV +AR G+ S +T+ D + N EVL
Sbjct: 203 VAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKANHMEVLD 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K + +++ + + IP
Sbjct: 263 AGKAAAQTLERFVSILMESIP 283
>gb|AAC37635.1| (L11291) purine nucleoside phosphorylase [Mus musculus]
Length = 289
Score = 81.1 bits (197), Expect = 1e-14
Identities = 67/261 (25%), Positives = 121/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAF--------IPRHGK 53
P++ +I GSG+ G+ + +I P+ P + + F + G+
Sbjct: 25 PQVAVICGSGLGGLTAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMMQGR 84
Query: 54 YHEFPPH---EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
+H + + +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFC 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFTAWKQMGEQRKLQEGTYVMLAGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AESR+ + AD +GM+ VPEV +AR G+ S +T+ D + N +EVL
Sbjct: 203 VAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKANHKEVLD 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K + +++ + + IP
Sbjct: 263 AGKAAAQTLERFVSILMESIP 283
>sp|P23492|PNPH_MOUSE PURINE NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|2117727|pir||I57010 purine-nucleoside phosphorylase
(EC 2.4.2.1) - mouse >gi|200098|gb|AAA39835.1| (M84563)
purine nucleoside phosphorylase [Mus musculus]
>gi|388919|gb|AAC37634.1| (L11290) purine nucleoside
phosphorylase [Mus musculus musculus]
Length = 289
Score = 80.8 bits (196), Expect = 2e-14
Identities = 67/261 (25%), Positives = 120/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAF--------IPRHGK 53
P++ +I GSG+ G+ + +I P+ P + + F + G+
Sbjct: 25 PQVAVICGSGLGGLTAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMMQGR 84
Query: 54 YHEFPPH---EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
+H + + +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFC 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFTAWKQMGEQRKLQEGTYVMLAGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AESR+ + AD +GM+ VPEV +AR G+ S +T+ D + N EVL
Sbjct: 203 VAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKANHMEVLD 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K + +++ + + IP
Sbjct: 263 AGKAAAQTLERFVSILMESIP 283
>pir||I76672 purine-nucleoside phosphorylase (EC 2.4.2.1) - western wild mouse
>gi|388923|gb|AAC37706.1| (L11292) purine nucleoside
phosphorylase [Mus spretus]
Length = 289
Score = 80.8 bits (196), Expect = 2e-14
Identities = 67/261 (25%), Positives = 120/261 (45%), Gaps = 23/261 (8%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVEIGEIEGVEVAF--------IPRHGK 53
P++ +I GSG+ G+ + +I P+ P + + F + G+
Sbjct: 25 PQVAVICGSGLGGLAAHLKEAQIFDYNEIPNFPQSTVQGHAGRLVFGLLNGRCCVMMQGR 84
Query: 54 YHEFPPH---EVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
+H + + +V + ++ L LGVE ++ NA G L ++ GDI++I I+
Sbjct: 85 FHMYEGYSLSKVTFPVRVFHL--LGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFC 142
Query: 111 EYTFYNGPK-----VAHVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
GP V +M+D + ++R+ K++G ++GTY+ + GP F T
Sbjct: 143 GQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAFTAWKQMGEQRKLQEGTYVMLAGPNFET 202
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTD---YDVWAEKPVNAQEVLR 220
AESR+ + AD +GM+ VPEV +AR G+ S +T+ D + N EVL
Sbjct: 203 VAESRLLKMLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVVMDYENLEKANHMEVLD 262
Query: 221 VMKENEEKVQKLLRKAIPKIP 241
K + +++ + + IP
Sbjct: 263 AGKAAAQTLERFVSILMESIP 283
>pir||H72233 purine nucleoside phosphorylase - Thermotoga maritima (strain
MSB8) >gi|4982167|gb|AAD36663.1|AE001804_7 (AE001804)
purine nucleoside phosphorylase [Thermotoga maritima]
Length = 265
Score = 79.6 bits (193), Expect = 4e-14
Identities = 56/191 (29%), Positives = 99/191 (51%), Gaps = 11/191 (5%)
Query: 52 GKYHEFPPHEVPYRA-NIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKR 110
G++H + H+ A ++ +GV+ ++ NA G++ E+KPG+I+++ I+F +
Sbjct: 78 GRFHLYEGHDPATVAFPVYLAKYVGVKGVVVTNAAGAINPEFKPGEIILVRDIINFMFRN 137
Query: 111 EYTFYNGPKVA--HVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAES 168
N K+ M+ PE R + + L L ++G YI + GP + T AE
Sbjct: 138 PLRGPNDEKIGPRFPDMSSVVDPEWAR---KIQERLSL---KEGVYIGVLGPSYETPAEI 191
Query: 169 RMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVTDYDVW-AEKPVNAQEVLRVMKENE 226
R+F + AD++GM+ VPEV A+ G+ V S VT+ ++ +EV+R K +
Sbjct: 192 RVFEKLGADLVGMSTVPEVIAAKHCGLKVVVFSCVTNMAAGITHGRLSHEEVVRTTKMAQ 251
Query: 227 EKVQKLLRKAI 237
K++K L A+
Sbjct: 252 GKIEKALTTAV 262
>sp|P45563|XAPA_ECOLI XANTHOSINE PHOSPHORYLASE >gi|7433918|pir||F65014 xanthosine
phosphorylase (EC 2.4.2.-) - Escherichia coli (strain
K-12) >gi|1788746|gb|AAC75460.1| (AE000328) xanthosine
phosphorylase [Escherichia coli K12]
>gi|1799817|dbj|BAA16275.1| (D90869) XANTHOSINE
PHOSPHORYLASE (EC 2.4.2.-). [Escherichia coli]
>gi|1799821|dbj|BAA16278.1| (D90870) XANTHOSINE
PHOSPHORYLASE (EC 2.4.2.-). [Escherichia coli]
Length = 277
Score = 75.3 bits (182), Expect = 7e-13
Identities = 62/216 (28%), Positives = 97/216 (44%), Gaps = 15/216 (6%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVE----------IGEIEGVEVAFIPRH 51
P++ I GSG+ + + E + P PV +G ++GV V +
Sbjct: 26 PRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGR 85
Query: 52 GKYHEFPPHEVPYRANIWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKRE 111
G ++E + A I LG E + NA GSL+ E G +V + I+
Sbjct: 86 GHFYEGRGMTIMTDA-IRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTP 144
Query: 112 YTFYNGPKVAH--VSMADPFCPELRRIFIETAKELGLPVHEKGTYICIEGPRFSTRAESR 169
N + S+A+ + E R + + AKE G P+ E G ++ GP F T AE R
Sbjct: 145 MVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTE-GVFVSYPGPNFETAAEIR 203
Query: 170 MFRQFA-DVIGMTLVPEVNLARELGMCYVNISTVTD 204
M + DV+GM++VPEV AR + V +S +T+
Sbjct: 204 MMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITN 239
>gb|AAF47653.1| (AE003475) CG16758 gene product [alt 4] [Drosophila melanogaster]
Length = 329
Score = 74.1 bits (179), Expect = 2e-12
Identities = 69/262 (26%), Positives = 117/262 (44%), Gaps = 25/262 (9%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVE----------IGEIEGVEVAFIPRH 51
PKIGII GSG+ + + + KI P+ PV +G +EG V +
Sbjct: 65 PKIGIICGSGLGSLADMIQDPKIFEYEKIPNFPVSTVEGHAGRLVVGTLEGATV--MAMQ 122
Query: 52 GKYHEFPPHEVPYRANIWALYEL-GVERIIAINAVGSLKEEYKPGDIVIIDQFID---FT 107
G++H + + + + + +L GVE + A NA G + + GDI+++ ++ F
Sbjct: 123 GRFHFYEGYPLAKCSMPVRVMKLCGVEYLFATNAAGGINPRFAVGDIMLMHDHVNMLGFA 182
Query: 108 KKREYTFYNGPKVA--HVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
N P+ ++ + + +L IE AK +G+ + G Y C+ GP + T
Sbjct: 183 GNSPLQGPNDPRFGPRFPALVNSYNKDLINKAIEIAKAMGIESNIHVGVYSCLGGPNYET 242
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTV-----TDYDVWAEKPVNAQEV 218
AE + R D +GM+ V EV AR M S + T+Y + N EV
Sbjct: 243 IAELKALRMMGVDAVGMSTVHEVITARHCDMKVFAFSLITNKCATEYSDKKDDEANHDEV 302
Query: 219 LRVMKENEEKVQKLLRKAIPKI 240
+ V K ++ +L+ + I +I
Sbjct: 303 MAVAKNRQKACCELVSRLIREI 324
>gb|AAF47654.1| (AE003475) CG16758 gene product [alt 3] [Drosophila melanogaster]
Length = 353
Score = 74.1 bits (179), Expect = 2e-12
Identities = 69/262 (26%), Positives = 117/262 (44%), Gaps = 25/262 (9%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVE----------IGEIEGVEVAFIPRH 51
PKIGII GSG+ + + + KI P+ PV +G +EG V +
Sbjct: 89 PKIGIICGSGLGSLADMIQDPKIFEYEKIPNFPVSTVEGHAGRLVVGTLEGATV--MAMQ 146
Query: 52 GKYHEFPPHEVPYRANIWALYEL-GVERIIAINAVGSLKEEYKPGDIVIIDQFID---FT 107
G++H + + + + + +L GVE + A NA G + + GDI+++ ++ F
Sbjct: 147 GRFHFYEGYPLAKCSMPVRVMKLCGVEYLFATNAAGGINPRFAVGDIMLMHDHVNMLGFA 206
Query: 108 KKREYTFYNGPKVA--HVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
N P+ ++ + + +L IE AK +G+ + G Y C+ GP + T
Sbjct: 207 GNSPLQGPNDPRFGPRFPALVNSYNKDLINKAIEIAKAMGIESNIHVGVYSCLGGPNYET 266
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTV-----TDYDVWAEKPVNAQEV 218
AE + R D +GM+ V EV AR M S + T+Y + N EV
Sbjct: 267 IAELKALRMMGVDAVGMSTVHEVITARHCDMKVFAFSLITNKCATEYSDKKDDEANHDEV 326
Query: 219 LRVMKENEEKVQKLLRKAIPKI 240
+ V K ++ +L+ + I +I
Sbjct: 327 MAVAKNRQKACCELVSRLIREI 348
>gb|AAF47655.1| (AE003475) CG16758 gene product [alt 2] [Drosophila melanogaster]
Length = 328
Score = 74.1 bits (179), Expect = 2e-12
Identities = 69/262 (26%), Positives = 117/262 (44%), Gaps = 25/262 (9%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVE----------IGEIEGVEVAFIPRH 51
PKIGII GSG+ + + + KI P+ PV +G +EG V +
Sbjct: 64 PKIGIICGSGLGSLADMIQDPKIFEYEKIPNFPVSTVEGHAGRLVVGTLEGATV--MAMQ 121
Query: 52 GKYHEFPPHEVPYRANIWALYEL-GVERIIAINAVGSLKEEYKPGDIVIIDQFID---FT 107
G++H + + + + + +L GVE + A NA G + + GDI+++ ++ F
Sbjct: 122 GRFHFYEGYPLAKCSMPVRVMKLCGVEYLFATNAAGGINPRFAVGDIMLMHDHVNMLGFA 181
Query: 108 KKREYTFYNGPKVA--HVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
N P+ ++ + + +L IE AK +G+ + G Y C+ GP + T
Sbjct: 182 GNSPLQGPNDPRFGPRFPALVNSYNKDLINKAIEIAKAMGIESNIHVGVYSCLGGPNYET 241
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTV-----TDYDVWAEKPVNAQEV 218
AE + R D +GM+ V EV AR M S + T+Y + N EV
Sbjct: 242 IAELKALRMMGVDAVGMSTVHEVITARHCDMKVFAFSLITNKCATEYSDKKDDEANHDEV 301
Query: 219 LRVMKENEEKVQKLLRKAIPKI 240
+ V K ++ +L+ + I +I
Sbjct: 302 MAVAKNRQKACCELVSRLIREI 323
>gb|AAF47656.1| (AE003475) CG16758 gene product [alt 1] [Drosophila melanogaster]
Length = 267
Score = 74.1 bits (179), Expect = 2e-12
Identities = 69/262 (26%), Positives = 117/262 (44%), Gaps = 25/262 (9%)
Query: 2 PKIGIIGGSGVYGVFEPKEVVKIHTPYGRPSAPVE----------IGEIEGVEVAFIPRH 51
PKIGII GSG+ + + + KI P+ PV +G +EG V +
Sbjct: 3 PKIGIICGSGLGSLADMIQDPKIFEYEKIPNFPVSTVEGHAGRLVVGTLEGATV--MAMQ 60
Query: 52 GKYHEFPPHEVPYRANIWALYEL-GVERIIAINAVGSLKEEYKPGDIVIIDQFID---FT 107
G++H + + + + + +L GVE + A NA G + + GDI+++ ++ F
Sbjct: 61 GRFHFYEGYPLAKCSMPVRVMKLCGVEYLFATNAAGGINPRFAVGDIMLMHDHVNMLGFA 120
Query: 108 KKREYTFYNGPKVA--HVSMADPFCPELRRIFIETAKELGLPVH-EKGTYICIEGPRFST 164
N P+ ++ + + +L IE AK +G+ + G Y C+ GP + T
Sbjct: 121 GNSPLQGPNDPRFGPRFPALVNSYNKDLINKAIEIAKAMGIESNIHVGVYSCLGGPNYET 180
Query: 165 RAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTV-----TDYDVWAEKPVNAQEV 218
AE + R D +GM+ V EV AR M S + T+Y + N EV
Sbjct: 181 IAELKALRMMGVDAVGMSTVHEVITARHCDMKVFAFSLITNKCATEYSDKKDDEANHDEV 240
Query: 219 LRVMKENEEKVQKLLRKAIPKI 240
+ V K ++ +L+ + I +I
Sbjct: 241 MAVAKNRQKACCELVSRLIREI 262
>gi|6323238 Purine Nucleoside Phosphorylase; Pnp1p [Saccharomyces cerevisiae]
>gi|2494051|sp|Q05788|PNPH_YEAST PROBABLE PURINE
NUCLEOSIDE PHOSPHORYLASE (INOSINE PHOSPHORYLASE) (PNP)
>gi|626447|pir||S48560 purine-nucleoside phosphorylase
(EC 2.4.2.1) YLR209c - yeast (Saccharomyces cerevisiae)
>gi|544515|gb|AAB67440.1| (U14913) Ylr209c:
purine-nucleoside phosphorylase [Saccharomyces
cerevisiae]
Length = 311
Score = 72.2 bits (174), Expect = 6e-12
Identities = 48/148 (32%), Positives = 78/148 (52%), Gaps = 10/148 (6%)
Query: 76 VERIIAINAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPKVAH-----VSMADPFC 130
V +I NA G + +Y+ D++ I ++ GP + ++++D +
Sbjct: 126 VRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYD 185
Query: 131 PELRRIFIETAKELGL--PVHEKGTYICIEGPRFSTRAESRMFRQF-ADVIGMTLVPEVN 187
ELR++ + KEL + P+HE GTY + GP F TRAES+M R D +GM+ VPEV
Sbjct: 186 LELRKLLFKKWKELKIQRPLHE-GTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVI 244
Query: 188 LARELGMCYVNISTVTDYDVWAEKPVNA 215
+AR G + +S +T+ V + P +A
Sbjct: 245 VARHCGWRVLALSLITNTCV-VDSPASA 271
>pir||T32981 hypothetical protein K02D7.1 - Caenorhabditis elegans
>gi|2854190|gb|AAC02605.1| (AF045645) similar to purine
nucleoside phosphorylases [Caenorhabditis elegans]
Length = 301
Score = 69.9 bits (168), Expect = 3e-11
Identities = 64/266 (24%), Positives = 125/266 (46%), Gaps = 40/266 (15%)
Query: 4 IGIIGGSGVYGVFEPKEVVKIHTPYGR-PSAPVE----------IGEIEGVEVAFIPRHG 52
+GII GSG+ + + + I PY + P P G++ G +V + G
Sbjct: 45 LGIICGSGLGPIGDTVQDATI-LPYSKIPGFPTTHVVGHKGNMIFGKLGGKKVVCL--QG 101
Query: 53 KYHEFPPHEVPYRAN---------IWALYELGVERIIAINAVGSLKEEYKPGDIVIIDQF 103
++H PY N + +++LG++ +I NA G + + GD+++I
Sbjct: 102 RFH-------PYEHNMDLALCTLPVRVMHQLGIKIMIVSNAAGGINAVLRHGDLMLIKDH 154
Query: 104 IDFTKKREYT---FYNGPK--VAHVSMADPFCPELRRIFIETAKELGLPVHEKGTYICIE 158
I ++ N P+ VS+ D + +LR++ I+ + + ++E G Y+
Sbjct: 155 IFLPALAGFSPLVGCNDPRFGARFVSVHDAYDKQLRQLAIDVGRRSDMTLYE-GVYVMSG 213
Query: 159 GPRFSTRAESRMFRQF-ADVIGMTLVPEVNLARELGMCYVNISTVT---DYDVWAEKPVN 214
GP++ + AE +F+ AD +GM+ EV +AR+ G+ + S +T + D A V+
Sbjct: 214 GPQYESPAEVSLFKTVGADALGMSTCHEVTVARQCGIKVLGFSLITNIANLDADASVEVS 273
Query: 215 AQEVLRVMKENEEKVQKLLRKAIPKI 240
+EV+ + ++ E+ + + I +I
Sbjct: 274 HEEVMDIAQQAGERASRFVSDIITEI 299
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.321 0.141 0.427
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101446467
Number of Sequences: 2977
Number of extensions: 4353649
Number of successful extensions: 10122
Number of sequences better than 1.0e-10: 58
Number of HSP's better than 0.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 9945
Number of HSP's gapped (non-prelim): 59
length of query: 257
length of database: 189,106,746
effective HSP length: 52
effective length of query: 205
effective length of database: 157,985,422
effective search space: 32387011510
effective search space used: 32387011510
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 164 (68.3 bits)