BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2317 (haeiii) DE:PROBABLE MODIFICATION METHYLASE
(309 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||F75190 probable modification methylase PAB2317 - Pyrococcus... 641 0.0
pir||D71222 probable modification methylase - Pyrococcus horikos... 419 e-116
pir||D72503 probable modification methylase APE2002 - Aeropyrum ... 303 2e-81
sp|Q57983|MT51_METJA PROBABLE MODIFICATION METHYLASE MJ0563 (CYT... 303 2e-81
gb|AAK40604.1| DNA modification methylase, type II R/M system [S... 284 7e-76
sp|Q58600|MT52_METJA PROBABLE MODIFICATION METHYLASE MJ1200 (CYT... 257 1e-67
sp|P05302|MTD1_DESDN MODIFICATION METHYLASE DDEI (CYTOSINE-SPECI... 184 1e-45
emb|CAA67412.1| (X98917) orf1 [Methanopyrus kandleri] 171 1e-41
sp|P50192|MTHC_HAEPH MODIFICATION METHYLASE HPHI(C) (CYTOSINE-SP... 166 3e-40
sp|P20589|MTH3_HAEAE MODIFICATION METHYLASE HAEIII (CYTOSINE-SPE... 155 8e-37
pdb|1DCT|A Chain A, Dna (Cytosine-5) Methylase From Haeiii Coval... 155 8e-37
gb|AAC97192.1| (AF056037) modification methylase M.NspHI [Nostoc... 153 3e-36
gb|AAC45838.1| (AF001598) 5-methylcytosine methyltransferase [Ne... 151 9e-36
emb|CAA74996.1| (Y14683) Bpu10I (5m)cytosine-specific DNA modifi... 150 2e-35
sp|P34906|MTF1_FUSNU MODIFICATION METHYLASE FNUDI (CYTOSINE-SPEC... 146 4e-34
gb|AAC97190.1| (AF056036) modification methylase M.NspI [Nostoc ... 145 5e-34
pir||C71933 type II DNA modification enzyme (methyltransferase) ... 145 9e-34
gi|10954474 TIM [Methanobacterium thermoautotrophicum] >gi|26658... 138 9e-32
emb|CAA74997.1| (Y14683) Bpu10I (5m)cytosine-specific DNA modifi... 137 2e-31
sp|P23737|MTS9_STAAU MODIFICATION METHYLASE SAU96I (CYTOSINE-SPE... 134 1e-30
sp|P08455|MTP2_NEIGO MODIFICATION METHYLASE NGOPII (CYTOSINE-SPE... 131 1e-29
pir||CTNHP2 site-specific DNA-methyltransferase (cytosine-specif... 131 1e-29
gb|AAB03209.1| (U42460) NgoII cytosine methylase M.NgoII [Neisse... 130 2e-29
dbj|BAB07227.1| (AP001519) cytosine-specific methyltransferase [... 130 3e-29
gb|AAB84141.1| (AF029070) FauI DNA methyltransferase [Flavobacte... 130 3e-29
gb|AAB59071.1| (L14563) cytosine methylase [Neisseria gonorrhoeae] 128 8e-29
gb|AAF06965.1|AF157599_4 (AF157599) EcoO109IM [Escherichia coli] 126 3e-28
sp|Q59606|MTF7_NEIGO MODIFICATION METHYLASE NGOFVII (CYTOSINE-SP... 125 5e-28
pir||F81959 site-specific DNA-methyltransferase (cytosine-specif... 124 1e-27
pir||C64580 site-specific DNA-methyltransferase (cytosine-specif... 121 1e-26
pir||C64526 site-specific DNA-methyltransferase (cytosine-specif... 121 1e-26
sp|P52311|MTX2_XANOR MODIFICATION METHYLASE XORII (CYTOSINE-SPEC... 120 2e-26
emb|CAA68841.1| (Y07554) type II DNA m5C-methyltransferase [Psyc... 118 7e-26
sp|P06530|MTBR_BACSU MODIFICATION METHYLASE BSURI (CYTOSINE-SPEC... 118 1e-25
gb|AAB70829.1| (AF019752) HaeII methylase [Haemophilus influenza... 116 3e-25
gb|AAF89681.1| (AF169965) cytosine-specific methyltransferase [B... 115 6e-25
pir||S76359 hypothetical protein - Synechocystis sp. (strain PCC... 115 7e-25
sp|P24600|MTD1_HERAU MODIFICATION METHYLASE HGIDI (CYTOSINE-SPEC... 115 7e-25
sp|P31033|MTM4_NEIGO MODIFICATION METHYLASE NGOMIV (CYTOSINE-SPE... 111 8e-24
emb|CAB44950.1| (AJ242840) DNA modification methylase [Neisseria... 110 2e-23
gb|AAC00045.1| (U13922) putative type II 5-cytosoine methyltrans... 109 3e-23
sp|P45000|MTD5_HAEIN PROBABLE MODIFICATION METHYLASE HINDV (CYTO... 109 6e-23
pir||S47248 site-specific DNA-methyltransferase (cytosine-specif... 108 1e-22
gb|AAG31558.1| (AF290880) SgrAIM methylase [Streptomyces griseus] 108 1e-22
gb|AAB03206.2| (U42459) cytosine DNA methylase M.NgoI [Neisseria... 107 2e-22
sp|P34882|MTAA_SYNP2 MODIFICATION METHYLASE AQUI ALPHA SUBUNIT (... 106 4e-22
sp|P25262|MTB1_HERAU MODIFICATION METHYLASE HGIBI (CYTOSINE-SPEC... 104 1e-21
sp|P25266|MTE1_HERAU MODIFICATION METHYLASE HGIEI (CYTOSINE-SPEC... 104 2e-21
sp|P34879|MTS2_SHISO MODIFICATION METHYLASE SSOII (CYTOSINE-SPEC... 104 2e-21
pir||JC4656 rRNA endonuclease (EC 3.1.27.10) AgeI - "Agrobacteri... 104 2e-21
gb|AAC45971.1| (U65460) DNA cytosine methyltransferase M.SenPI [... 104 2e-21
pir||JC5542 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - ... 104 2e-21
sp|P50196|MTE8_ECOLI MODIFICATION METHYLASE ECO47II (CYTOSINE-SP... 102 4e-21
sp|P13906|MTB1_BACSH MODIFICATION METHYLASE BSPRI (CYTOSINE-SPEC... 102 4e-21
sp|P34877|MTSA_LACLC MODIFICATION METHYLASE SCRFIA (CYTOSINE-SPE... 102 7e-21
sp|P25264|MTC2_HERAU MODIFICATION METHYLASE HGICII (CYTOSINE-SPE... 101 1e-20
pir||JC1165 site-specific DNA-methyltransferase (cytosine-specif... 101 1e-20
gb|AAC97118.1| (AF027867) SacI methylase [Streptomyces achromoge... 101 2e-20
gb|AAC37047.1| (L09189) orf; homologous to Haemophilus parahaemo... 100 2e-20
emb|CAA73243.1| (Y12707) methylase [Lactococcus lactis subsp. cr... 100 3e-20
emb|CAA33764.1| (X15758) methylase [Bacillus sphaericus] 100 4e-20
emb|CAA33765.1| (X15758) methylase [Bacillus sphaericus] 100 4e-20
pir||I40424 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - ... 99 5e-20
sp|P24581|MTNX_NEILA CYTOSINE-SPECIFIC METHYLTRANSFERASE NLAX (M... 96 5e-19
pir||B39467 site-specific DNA-methyltransferase (cytosine-specif... 96 5e-19
sp|P25282|MTG1_HAEGA MODIFICATION METHYLASE HGAI-1 (CYTOSINE-SPE... 96 5e-19
pir||A81101 C-5 cytosine-specific DNA-methylase NMB1290 [importe... 96 5e-19
gi|10955252 DNA-methyltransferase [Escherichia coli] >gi|1237268... 96 7e-19
emb|CAB46561.1| (AJ242480) putative cytosine-specific methyl tra... 95 9e-19
gb|AAC49849.1| (AF025475) Masc1 [Ascobolus immersus] 94 3e-18
pir||JC4986 site-specific DNA-methyltransferase (cytosine-specif... 93 4e-18
gb|AAC45757.1| (AF020002) M.BssHII methylase [Bacillus stearothe... 93 4e-18
sp|P09795|MTSI_SALIN MODIFICATION METHYLASE SINI (CYTOSINE-SPECI... 93 5e-18
sp|P50185|MTD5_DACSA MODIFICATION METHYLASE DSAV (CYTOSINE-SPECI... 91 1e-17
sp|P43420|MTB6_BACSP MODIFICATION METHYLASE BSP6I (CYTOSINE-SPEC... 91 1e-17
gb|AAC97180.1| (AF044847) ApaLI methyltransferase [Acetobacter p... 91 2e-17
sp|P34905|MTB1_BACBR MODIFICATION METHYLASE BBVI (CYTOSINE-SPECI... 90 2e-17
gb|AAB21481.2| (S86113) cytosine DNA methyltransferase homolog [... 90 2e-17
gb|AAC98421.1| (L29323) methyl transferase [Streptococcus pneumo... 90 3e-17
sp|P17044|MTBF_BACSU MODIFICATION METHYLASE BSUFI (CYTOSINE-SPEC... 89 7e-17
sp|P05102|MTH1_HAEHA MODIFICATION METHYLASE HHAI (CYTOSINE-SPECI... 89 7e-17
sp|P13864|MTDM_MOUSE DNA (CYTOSINE-5)-METHYLTRANSFERASE (DNA MET... 88 1e-16
gb|AAC40061.1| (AF036007) DNA (cytosine-5)-methyltransferase [Mu... 88 1e-16
gi|6753664 DNA methyltransferase (cytosine-5) [Mus musculus] >gi... 88 1e-16
gb|AAF60965.1| (AF175431) DNA methyltransferase [Mus musculus] >... 88 1e-16
pir||JC5145 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - ... 87 2e-16
pir||JE0378 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - ... 87 2e-16
pir||JC4172 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - ... 87 3e-16
gb|AAF73200.1|AF152342_1 (AF152342) DNA-(cytosine-5)-methyltrans... 86 5e-16
emb|CAA90563.1| (Z50183) DNA (cytosine-5-)-methyltransferase [Pa... 86 6e-16
pir||JC5210 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - ... 86 6e-16
sp|P26358|MTDM_HUMAN DNA (CYTOSINE-5)-METHYLTRANSFERASE (DNA MET... 85 8e-16
gi|4503351 DNA (cytosine-5-)-methyltransferase 1; DNA methyltran... 85 8e-16
gb|AAF23609.1| (AF180682) DNA (cytosine-5)-methyltransferase [Ho... 85 8e-16
gi|11424851 DNA (cytosine-5-)-methyltransferase 1 [Homo sapiens] 85 8e-16
gb|AAC69603.1| (AF097875) DNA methyltransferase [Danio rerio] 84 2e-15
emb|CAC10091.1| (AL442164) related to cytosine C5-DNA methyltran... 84 2e-15
sp|P25267|MTG1_HERAU MODIFICATION METHYLASE HGIGI (CYTOSINE-SPEC... 84 2e-15
sp|P50188|MTN1_NOCAE MODIFICATION METHYLASE NAEI (CYTOSINE-SPECI... 82 7e-15
gb|AAG17898.1|AF297971_2 (AF297971) DNA cytosine methyltransfera... 81 2e-14
gb|AAB95336.1| (AF039582) EaeI methyltransferase alpha subunit [... 81 2e-14
gb|AAC77904.1| (AF051563) LlaKR2I methylase enzyme [Lactococcus ... 81 2e-14
pir||A81952 site-specific DNA-methyltransferase (cytosine-specif... 80 3e-14
pir||A81155 C-5 cytosine-specific DNA methylase NMB0826 [importe... 80 3e-14
gb|AAD32180.1|AF125564_2 (AF125564) putative site specific DNA m... 79 6e-14
sp|P11408|MTM1_MORSP MODIFICATION METHYLASE MSPI (CYTOSINE-SPECI... 77 3e-13
emb|CAB09661.1| (Z96933) DNA-C5-methyltransferase [Ascobolus imm... 77 3e-13
pir||I41075 site-specific DNA-methyltransferase (cytosine-specif... 76 4e-13
emb|CAA57706.1| (X82231) M.EcoHK31I alpha polypeptide [Escherich... 76 4e-13
sp|P00476|MTBS_BPSPR MODIFICATION METHYLASE SPRI (CYTOSINE-SPECI... 75 1e-12
pir||S02599 site-specific DNA-methyltransferase (cytosine-specif... 75 1e-12
gb|AAA32604.1| (K02124) DNA methyltransferase (Mtase; ttg start)... 75 1e-12
pir||T09107 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - ... 75 1e-12
sp|P16668|MTS3_STAAU MODIFICATION METHYLASE SAU3AI (CYTOSINE-SPE... 75 2e-12
pir||G81130 modification methylase NlaIV NMB1033 [imported] - Ne... 73 3e-12
pir||D81836 site-specific DNA-methyltransferase (cytosine-specif... 73 3e-12
pir||JQ1019 site-specific DNA-methyltransferase (cytosine-specif... 73 4e-12
gb|AAA69959.1| (M72412) 5C-DNA methyltransferase [Bacillus amylo... 73 4e-12
sp|P09915|MTBR_BPRH1 MODIFICATION METHYLASE RHO11SI (CYTOSINE-SP... 72 8e-12
sp|P50182|MTN4_NEILA MODIFICATION METHYLASE NLAIV (CYTOSINE-SPEC... 72 1e-11
gb|AAA86268.1| (U43735) M.NgoV DNA methylase [Neisseria gonorrho... 72 1e-11
sp|P34883|MTAB_SYNP2 MODIFICATION METHYLASE AQUI BETA SUBUNIT (C... 70 4e-11
sp|P19888|MTBA_BACAR MODIFICATION METHYLASE BANI (CYTOSINE-SPECI... 69 5e-11
>pir||F75190 probable modification methylase PAB2317 - Pyrococcus abyssi
(strain Orsay) >gi|5457482|emb|CAB48973.1| (AJ248283)
PROBABLE MODIFICATION METHYLASE [Pyrococcus abyssi]
Length = 309
Score = 641 bits (1636), Expect = 0.0
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 1 MGEGNKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIK 60
MGEGNKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIK
Sbjct: 1 MGEGNKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIK 60
Query: 61 VISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV 120
VISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV
Sbjct: 61 VISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV 120
Query: 121 FVMENVPQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKG 180
FVMENVPQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKG
Sbjct: 121 FVMENVPQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKG 180
Query: 181 PRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPT 240
PRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPT
Sbjct: 181 PRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPT 240
Query: 241 VRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFI 300
VRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFI
Sbjct: 241 VRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFI 300
Query: 301 FDVLSKERI 309
FDVLSKERI
Sbjct: 301 FDVLSKERI 309
>pir||D71222 probable modification methylase - Pyrococcus horikoshii
>gi|3256424|dbj|BAA29107.1| (AP000001) 238aa long
hypothetical modification methylase [Pyrococcus
horikoshii]
Length = 238
Score = 419 bits (1065), Expect = e-116
Identities = 188/238 (78%), Positives = 219/238 (91%)
Query: 72 VIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQIME 131
+IIGGPPCEPFTAIN RR+E+P+DRLY+DPIGRLVLEF+RFV LKPKVFVMENVPQIME
Sbjct: 1 MIIGGPPCEPFTAINSRRREHPRDRLYKDPIGRLVLEFIRFVRELKPKVFVMENVPQIME 60
Query: 132 LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKGPRKVWDALKNI 191
+E+Y+R+EF++AGYD+YFNV NALDYG PQVRRRVFISN+ELKP+KI+ ++VWDAL++I
Sbjct: 61 VERYIRREFERAGYDVYFNVFNALDYGVPQVRRRVFISNIELKPRKIRSRKRVWDALRDI 120
Query: 192 PIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPTVRGNSRFVHPF 251
P APN++ W+PPS+IAR+IP LRWGE QRFGRFQNWIRLHPYKPAPTVRGNSRF+HPF
Sbjct: 121 PPGAPNNEIWNPPSRIARKIPYLRWGEAGQRFGRFQNWIRLHPYKPAPTVRGNSRFIHPF 180
Query: 252 EDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLSKERI 309
EDRPLTVREQARLMGFPD FVFLGGRNVQFDSVGEAVPPPLAKAIA+FI + ++ +
Sbjct: 181 EDRPLTVREQARLMGFPDYFVFLGGRNVQFDSVGEAVPPPLAKAIADFILSTIDEQNL 238
>pir||D72503 probable modification methylase APE2002 - Aeropyrum pernix (strain
K1) >gi|5105700|dbj|BAA81012.1| (AP000063) 327aa long
hypothetical modification methylase [Aeropyrum pernix]
Length = 327
Score = 303 bits (768), Expect = 2e-81
Identities = 165/320 (51%), Positives = 210/320 (65%), Gaps = 26/320 (8%)
Query: 12 DLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI---- 67
D+FAG GGFS GF+ GF + AI+N+ P A+TY NFP IA D+K + +EI
Sbjct: 9 DVFAGGGGFSRGFEEAGFRVRVAIDNYPPAARTYKANFPHTAFIADDVKEVGLEEISSVS 68
Query: 68 ----GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
G+VDV+I PPCEPFT NPRR E P DRLYRDP G+L L +R + LKP+ FV+
Sbjct: 69 GLSPGEVDVVIASPPCEPFTGANPRRMERPLDRLYRDPAGQLFLHAIRLIGLLKPRFFVI 128
Query: 124 ENVPQIM--ELEKYLRKEFDKAGYD-IYFNVLNALDYGAPQVRRRVFISNLELKPKKIKG 180
ENVP I E+E+ +R E KAGY +YFN+L A ++G P R RVF+SN L+P + +G
Sbjct: 129 ENVPGIAHPEIERAVRMELSKAGYRRVYFNLLRAEEHGTPSRRLRVFVSNARLRPPRRRG 188
Query: 181 PRKVWDALKNIPIDA----PNHDFWSPPSKIAR---RIPRLRWGEGAQRFG-----RFQN 228
P V + LK++P PNH+ +PP AR R RLR GEG +F R N
Sbjct: 189 P-SVGEVLKDLPEPGAAWPPNHE--APPELPARKMRRAARLRAGEGLIQFQGAGGRRIPN 245
Query: 229 WIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAV 288
+IRL P PAPTV G+ RF+HP++DR LTVREQARLMGFPD +FLG R+ Q++ VGEAV
Sbjct: 246 YIRLDPDAPAPTVMGSRRFIHPWQDRLLTVREQARLMGFPDYHIFLGSRDAQYNMVGEAV 305
Query: 289 PPPLAKAIANFIFDVLSKER 308
PPPLAKAIA ++ +L ER
Sbjct: 306 PPPLAKAIAEYLAALLEDER 325
>sp|Q57983|MT51_METJA PROBABLE MODIFICATION METHYLASE MJ0563 (CYTOSINE-SPECIFIC
METHYLTRANSFERASE MJ0563) (M.MJAVIIIP)
>gi|2129122|pir||C64370 modification methylase (EC
2.1.1.-) homolog - Methanococcus jannaschii
>gi|1591269|gb|AAB98555.1| (U67505) modification
methylase, type II R/M system [Methanococcus jannaschii]
Length = 310
Score = 303 bits (767), Expect = 2e-81
Identities = 161/307 (52%), Positives = 204/307 (66%), Gaps = 15/307 (4%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
M V+DLF+G GGFS GF F I+ AIENFKP KTY +N V DIK I P
Sbjct: 1 MNVIDLFSGCGGFSKGFLDENFRILGAIENFKPVVKTYLYNIKA-PVWMDDIKRIPPKAF 59
Query: 68 GD------VDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFV----ERLK 117
+ VDVIIG PPCEPFT N K+NP DRLY+D +GRLVL ++ +V +R
Sbjct: 60 DEFIKNEKVDVIIGSPPCEPFTKANKLIKDNPLDRLYKDKVGRLVLYYIDYVNYFTQRND 119
Query: 118 PKVFVMENVPQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKK 177
+FVMENVPQI E++ L+K F G+ +YFN+L A DYG P R R+FISN++LKPKK
Sbjct: 120 DLIFVMENVPQIKEIKDELKKLFGDIGHKVYFNILRAEDYGNPSKRARMFISNIKLKPKK 179
Query: 178 IKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRF-GRFQ---NWIRLH 233
+ V +ALK+IP DA NH+ + I +L+WGE R+ G+ + NW +LH
Sbjct: 180 VDKLVVVEEALKDIPKDAKNHEIKKLSKEKVEMISKLKWGEALYRYRGKKKLMFNWYKLH 239
Query: 234 PYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLA 293
P K APTV+G SRF+HP+EDR LTVREQARLM +PDDFVF GGR+VQ++ +GE+VPP L
Sbjct: 240 PKKLAPTVKGRSRFIHPYEDRLLTVREQARLMSYPDDFVFFGGRDVQYNQIGESVPPILG 299
Query: 294 KAIANFI 300
+AIA I
Sbjct: 300 RAIAKEI 306
>gb|AAK40604.1| DNA modification methylase, type II R/M system [Sulfolobus
solfataricus]
Length = 325
Score = 284 bits (720), Expect = 7e-76
Identities = 156/318 (49%), Positives = 208/318 (65%), Gaps = 16/318 (5%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
+K++DLF+GAGGFSLGFK +G E AI+ +TYS NFP VI DI+ IS EI
Sbjct: 4 IKIIDLFSGAGGFSLGFKKLGIEPKLAIDINHAATRTYSLNFPNTIVIEDDIREISGGEI 63
Query: 68 -----GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFV 122
D+DV+IGGPPCE +TA NP R ++P DRLY D G L LEF+R V+ +KPK+FV
Sbjct: 64 LKNVGNDIDVVIGGPPCEGYTAANPLRMQDPLDRLYLDQRGNLTLEFIRIVDEVKPKIFV 123
Query: 123 MENVPQIME---LEKYLRKEFDKAGY-DIYFNVLNALDYGAPQVRRRVFISNLELKPKKI 178
MENVP I+E L L EF KAGY +I+FN+L+A DYG P R RVFISN+ + P K
Sbjct: 124 MENVPAIIETQSLRDALINEFKKAGYGNIFFNILHAEDYGNPSKRSRVFISNVRISPIKN 183
Query: 179 KGPRKVWDALKNIP--IDAPNHDFWSPPSKIARRIPRLRWGE-----GAQRFGRFQNWIR 231
+ V+DA+ ++ +D PN++ P K +I ++ +G+ A + +IR
Sbjct: 184 QKRITVYDAIHDLDNKLDVPNNEVSEPNEKKLLKISKIGYGKYLTMYRASKGRSIPLYIR 243
Query: 232 LHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPP 291
L P+ APT+ GNSRF+HPF DR LTVREQARLM +PDD VFLG ++ Q++ VGE+VP
Sbjct: 244 LSPFDLAPTILGNSRFIHPFHDRFLTVREQARLMSYPDDHVFLGSKDEQYNQVGESVPVA 303
Query: 292 LAKAIANFIFDVLSKERI 309
L+ AIA I +L++ I
Sbjct: 304 LSTAIAKEILGILNERTI 321
>sp|Q58600|MT52_METJA PROBABLE MODIFICATION METHYLASE MJ1200 (CYTOSINE-SPECIFIC
METHYLTRANSFERASE MJ1200) (M.MJAVIIP)
>gi|2129124|pir||G64449 modification methylase (EC
2.1.1.-) homolog - Methanococcus jannaschii
>gi|1591829|gb|AAB99203.1| (U67561) modification
methylase, type II R/M system [Methanococcus jannaschii]
Length = 366
Score = 257 bits (650), Expect = 1e-67
Identities = 152/360 (42%), Positives = 204/360 (56%), Gaps = 70/360 (19%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPG---------------- 51
+K +DLF G GGFS GF GFE + AIE + A +Y+ NF G
Sbjct: 5 LKFIDLFCGCGGFSRGFVEEGFEPLVAIELNEDAAFSYALNFNGQIYEKIRPGEFKLKEL 64
Query: 52 -----------------------VKVIAQDIKVISPDEIGD------------------V 70
+ + + K +SP I D V
Sbjct: 65 KGYVGIYPFKFPFEEEDIKWLKRLGTLNEKTKKLSPVVINDDIREIHAIEIEKFIKNKKV 124
Query: 71 DVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQIM 130
DVIIGGPPCE +T NP+R++NP DRLY+D GRLVLE++R V L+PK+FVMENVP I
Sbjct: 125 DVIIGGPPCEGYTGANPKREKNPYDRLYKDETGRLVLEYIRIVGDLQPKIFVMENVPGIK 184
Query: 131 ELEKYLRKEFDKAGY-DIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKGPRKVWDALK 189
E+ + KEF + GY D+YFN L A DYG P VRRRVF+SN+E+ P+K + P+ V +A+
Sbjct: 185 EVRGAIIKEFREIGYEDVYFNTLRAEDYGNPSVRRRVFVSNIEINPEKTQ-PKTVIEAIG 243
Query: 190 NIPI---DAPNHDFWSPPSKIARRIPRLRWGE------GAQRFGRFQNWIRLHPYKPAPT 240
++ D PNH+F + P++ +R+ +L WG+ GA R R N+IRLHP K A T
Sbjct: 244 DLMYKGRDVPNHEFAALPARFRKRVHKLGWGDAFIYFKGANR--RLGNYIRLHPLKLAET 301
Query: 241 VRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFI 300
V G F+HP+EDR LT REQARLM +PD +F GG ++ +GE+VP L++AIA I
Sbjct: 302 VMGKRFFIHPYEDRLLTPREQARLMSYPDYHLFAGGIRSCYNQIGESVPVALSRAIARVI 361
>sp|P05302|MTD1_DESDN MODIFICATION METHYLASE DDEI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
DDEI) (M.DDEI) >gi|79418|pir||S00543 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
DdeI - Desulfovibrio desulfuricans
>gi|40795|emb|CAA68505.1| (Y00449) DdeI methylase
[Desulfovibrio vulgaris]
Length = 415
Score = 184 bits (462), Expect = 1e-45
Identities = 124/374 (33%), Positives = 180/374 (47%), Gaps = 89/374 (23%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDE- 66
M ++DLFAG GGFS GFK+ G+ + AIE ++TYS N P V VI +DI + P +
Sbjct: 1 MNIIDLFAGCGGFSHGFKMAGYNSILAIEKDLWASQTYSFNNPNVSVITEDITTLDPGDL 60
Query: 67 ---IGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
+ DVD IIGGPPC+ F+ R +++P++ L+ ++FVRFV+ PK FVM
Sbjct: 61 KISVSDVDGIIGGPPCQGFSLSGNRDQKDPRNSLF--------VDFVRFVKFFSPKFFVM 112
Query: 124 ENVPQIMELEKYLR--------KEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLE--- 172
ENV I+ ++ R +EF GY + +LNA DYG PQ R+RVF L+
Sbjct: 113 ENVLGILSMKTKSRQYVKDIIAEEFSNVGYKVCVIILNACDYGVPQSRQRVFFIGLKSDR 172
Query: 173 -LKPKKIKGPRKV--------WDALKNIPI----------DAP----------------- 196
L + + P KV +A+ ++P+ D P
Sbjct: 173 PLNQQILTPPSKVIESEYTSLEEAISDLPVIEAGEGGEVQDYPVAPRNKYQENMRKGSTC 232
Query: 197 --NHDFWSPPSKIARRIPRLRWGEGAQRFGR------------------FQNWIRLHPYK 236
NH ++ R +++G+ + QN +R +PYK
Sbjct: 233 VYNHVAMRHTQRLVDRFAAIKFGQSVKHVSEEHSQRKRGDANSISGKVFSQNNMRPYPYK 292
Query: 237 PAPTVRGN--SRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNV--------QFDSVGE 286
P PTV + S F+HPF +R T RE AR+ FPD ++F G R Q+ +G
Sbjct: 293 PCPTVAASFQSNFIHPFYNRNFTAREGARIQSFPDTYIFQGKRTTMSWEKHLSQYQQIGN 352
Query: 287 AVPPPLAKAIANFI 300
AVPP LA+A+A I
Sbjct: 353 AVPPLLAQALAERI 366
>emb|CAA67412.1| (X98917) orf1 [Methanopyrus kandleri]
Length = 146
Score = 171 bits (429), Expect = 1e-41
Identities = 90/144 (62%), Positives = 105/144 (72%), Gaps = 7/144 (4%)
Query: 9 KVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP---- 64
KV+DLF GAGGFS GFK GF+I+ +EN A TY NFP +VI +DI+ +
Sbjct: 4 KVVDLFCGAGGFSRGFKEAGFKILGGVENNPAPAATYRENFPEAEVIERDIQRVDSEEIV 63
Query: 65 DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVME 124
DE+G+ DVIIGGPPCEPFTA N RK NP DRLY DP+GRLVL FVR + L+P+VFVME
Sbjct: 64 DELGEPDVIIGGPPCEPFTAAN-ARKPNPLDRLYDDPVGRLVLHFVRIIGDLQPEVFVME 122
Query: 125 NVPQIME--LEKYLRKEFDKAGYD 146
NVP IME LEK LRKEF +AGYD
Sbjct: 123 NVPAIMEGPLEKALRKEFARAGYD 146
>sp|P50192|MTHC_HAEPH MODIFICATION METHYLASE HPHI(C) (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HPHI(C)) (M.HPHI(C)) >gi|1086236|pir||S53120
site-specific DNA-methyltransferase (cytosine-specific)
(EC 2.1.1.73) - Haemophilus parahaemolyticus
>gi|2148052|pir||S70707 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
HphI - Haemophilus parahaemolyticus (ATCC 49700)
>gi|732729|emb|CAA59690.1| (X85374) site-specific
DNA-methyltransferase (cytosine-specific) [Haemophilus
parahaemolyticus]
Length = 372
Score = 166 bits (416), Expect = 3e-40
Identities = 117/333 (35%), Positives = 174/333 (52%), Gaps = 44/333 (13%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI--- 67
+DLF+GAGGFSLGF GF + ++E TY NFP +V+ QD+ +S D +
Sbjct: 48 IDLFSGAGGFSLGFDRAGFHQLLSVEIEPHYCDTYRANFPDHQVLQQDLTTLSDDNLLRH 107
Query: 68 ---GDVDVIIGGPPCEPFTA---INPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVF 121
VDV+IGGPPC+ F+ I ++P++ L++ EFVR V+ +PK F
Sbjct: 108 INHRKVDVVIGGPPCQGFSMAGKIGRTFADDPRNHLFK--------EFVRVVKLTQPKFF 159
Query: 122 VMENVPQIM-----ELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRR-VFISNLELKP 175
VMENV ++ + + ++F++ GY + VLNA D+G PQ+R R VFI +
Sbjct: 160 VMENVARLFTHNSGKTRAEITEQFERLGYKVKCKVLNAADFGVPQLRSRIVFIGRKDGGE 219
Query: 176 KKIKGP-----RKVWDALKNIP-IDAP------NHDFWSPPSKIARRIPRLRWGEGAQRF 223
P V DA+ + P ++A NH+ + +++ ++ ++ G
Sbjct: 220 ITFPEPSHTEYNTVGDAIGHFPKLNAGENSLILNHEAMNHSTQMLEKMSFVKNGGDRNDI 279
Query: 224 --------GRFQNWIRLHPYKPAPTVRGNSRFVHPFE-DRPLTVREQARLMGFPDDFVFL 274
G + +IR H KP+ V G+ R V +E +R LTVRE A L FPDDFVFL
Sbjct: 280 PESLRPISGDVRKYIRYHSDKPSVCVTGDMRKVFHYEQNRALTVRELAALQSFPDDFVFL 339
Query: 275 GGRNVQFDSVGEAVPPPLAKAIANFIFDVLSKE 307
G + Q VG AVPP LA+AIA + + + E
Sbjct: 340 GKKIAQQQQVGNAVPPLLAQAIAEAVLKMNTNE 372
>sp|P20589|MTH3_HAEAE MODIFICATION METHYLASE HAEIII (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HAEIII) (M.HAEIII) >gi|79296|pir||JS0102 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
HaeIII - Haemophilus aegyptius >gi|148915|gb|AAA24970.1|
(M24625) methyltransferase [Haemophilus influenzae
biogroup aegyptius] >gi|2961233|gb|AAC05696.1|
(AF051375) HaeIII DNA modification methyltransferase
[Haemophilus influenzae biogroup aegyptius]
Length = 330
Score = 155 bits (387), Expect = 8e-37
Identities = 125/334 (37%), Positives = 167/334 (49%), Gaps = 47/334 (14%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
M ++ LF+GAGG LGF+ GF I+ A E K KTY N K+I DI IS DE
Sbjct: 1 MNLISLFSGAGGLDLGFQKAGFRIICANEYDKSIWKTYESNH-SAKLIKGDISKISSDEF 59
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
D IIGGPPC+ ++ E R DP G+L E++R +++ KP F+ ENV
Sbjct: 60 PKCDGIIGGPPCQSWS-------EGGSLRGIDDPRGKLFYEYIRILKQKKPIFFLAENVK 112
Query: 128 QIME------LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF---------ISNLE 172
+M ++++++ EFD AGYD++ +LNA DYG Q R+RVF I+ L
Sbjct: 113 GMMAQRHNKAVQEFIQ-EFDNAGYDVHIILLNANDYGVAQDRKRVFYIGFRKELNINYLP 171
Query: 173 LKPKKIKGPRK--VWDALKNIPIDA-------------PNHDFW-SPPSKIARRIPRLR- 215
P IK K +WD LK+ PI A PNH+++ S I R+R
Sbjct: 172 PIPHLIKPTFKDVIWD-LKDNPIPALDKNKTNGNKCIYPNHEYFIGSYSTIFMSRNRVRQ 230
Query: 216 WGEGAQRFGRFQNWIRLHPYKPA--PTVRGNSRFVHPFED--RPLTVREQARLMGFPDDF 271
W E A +LHP P + ++FV E R LTVRE AR+ GFPDDF
Sbjct: 231 WNEPAFTVQASGRQCQLHPQAPVMLKVSKNLNKFVEGKEHLYRRLTVRECARVQGFPDDF 290
Query: 272 VF-LGGRNVQFDSVGEAVPPPLAKAIANFIFDVL 304
+F N + +G AVP LA IA I L
Sbjct: 291 IFHYESLNDGYKMIGNAVPVNLAYEIAKTIKSAL 324
>pdb|1DCT|A Chain A, Dna (Cytosine-5) Methylase From Haeiii Covalently Bound To
Dna >gi|1127163|pdb|1DCT|B Chain B, Dna (Cytosine-5)
Methylase From Haeiii Covalently Bound To Dna
Length = 324
Score = 155 bits (387), Expect = 8e-37
Identities = 125/334 (37%), Positives = 167/334 (49%), Gaps = 47/334 (14%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
M ++ LF+GAGG LGF+ GF I+ A E K KTY N K+I DI IS DE
Sbjct: 1 MNLISLFSGAGGLDLGFQKAGFRIICANEYDKSIWKTYESNH-SAKLIKGDISKISSDEF 59
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
D IIGGPPC+ ++ E R DP G+L E++R +++ KP F+ ENV
Sbjct: 60 PKCDGIIGGPPCQSWS-------EGGSLRGIDDPRGKLFYEYIRILKQKKPIFFLAENVK 112
Query: 128 QIME------LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF---------ISNLE 172
+M ++++++ EFD AGYD++ +LNA DYG Q R+RVF I+ L
Sbjct: 113 GMMAQRHNKAVQEFIQ-EFDNAGYDVHIILLNANDYGVAQDRKRVFYIGFRKELNINYLP 171
Query: 173 LKPKKIKGPRK--VWDALKNIPIDA-------------PNHDFW-SPPSKIARRIPRLR- 215
P IK K +WD LK+ PI A PNH+++ S I R+R
Sbjct: 172 PIPHLIKPTFKDVIWD-LKDNPIPALDKNKTNGNKCIYPNHEYFIGSYSTIFMSRNRVRQ 230
Query: 216 WGEGAQRFGRFQNWIRLHPYKPA--PTVRGNSRFVHPFED--RPLTVREQARLMGFPDDF 271
W E A +LHP P + ++FV E R LTVRE AR+ GFPDDF
Sbjct: 231 WNEPAFTVQASGRQCQLHPQAPVMLKVSKNLNKFVEGKEHLYRRLTVRECARVQGFPDDF 290
Query: 272 VF-LGGRNVQFDSVGEAVPPPLAKAIANFIFDVL 304
+F N + +G AVP LA IA I L
Sbjct: 291 IFHYESLNDGYKMIGNAVPVNLAYEIAKTIKSAL 324
>gb|AAC97192.1| (AF056037) modification methylase M.NspHI [Nostoc ATCC29106]
Length = 397
Score = 153 bits (382), Expect = 3e-36
Identities = 106/326 (32%), Positives = 165/326 (50%), Gaps = 43/326 (13%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD----E 66
+DLF GAGG + G GF+ +A++E + T+ NFP DI+ SP +
Sbjct: 63 VDLFCGAGGITQGLIQAGFQALASVETSSIASATHQRNFPHCHHFCGDIEQFSPKIWLKQ 122
Query: 67 IG--DVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVME 124
IG +V++++GGPPC+ F+ R ++P++RL+ EFVR V ++P VME
Sbjct: 123 IGSPEVNLVVGGPPCQGFSVAGKRDPKDPRNRLF--------YEFVRVVSEIRPWYVVME 174
Query: 125 NVPQIMELEKYLRKE-----FDKAGY-DIYFNVLNALDYGAPQVR-RRVFISN------- 170
NVP I+ ++ K+ F+ GY +I +L + DYG PQ+R R +FI+N
Sbjct: 175 NVPGILTIQNGNVKQAIIEAFESIGYPNISVAILESADYGIPQIRPRAIFIANRFGMPNP 234
Query: 171 ---LELKPKKIKGPRK-VWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRF 226
+L P+K K + D + PI NH + + RI ++ G +
Sbjct: 235 YPKAQLSPEKYKPIESAISDLPEYTPIPEINHQWTRHSPEYMERIAKVPPGGSL-----Y 289
Query: 227 QNWI----RLHPYKPAPTVRGN--SRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQ 280
Q ++ R +P KP+ TV+ N +HP+ +R ++ RE ARL FPD F+F G
Sbjct: 290 QKYVDAFKRQYPGKPSMTVKENHGGTHIHPYLNRVISAREMARLQTFPDSFIFEGTMKKA 349
Query: 281 FDSVGEAVPPPLAKAIANFIFDVLSK 306
+G AVPP LA+ I + L+K
Sbjct: 350 MWQIGNAVPPRLAECIGYALIPYLNK 375
>gb|AAC45838.1| (AF001598) 5-methylcytosine methyltransferase [Neisseria
gonorrhoeae]
Length = 333
Score = 151 bits (378), Expect = 9e-36
Identities = 106/335 (31%), Positives = 171/335 (50%), Gaps = 47/335 (14%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIGD- 69
+DLF+GAGG SLGF+ GF+ + ++E +TY NFP +++ +D+ ++ ++ +
Sbjct: 8 IDLFSGAGGLSLGFEQAGFQQLLSVEMESDYCQTYRTNFPRHQLLQKDLTTLTEQDLTNC 67
Query: 70 -----VDVIIGGPPCEPFTA---INPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVF 121
VD++IGGPPC+ F+ I ++P++ L++ EFVR V+ ++P F
Sbjct: 68 LNGQSVDLVIGGPPCQGFSMAGKIGRTFTDDPRNHLFK--------EFVRIVKIVQPYFF 119
Query: 122 VMENVPQIM-----ELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPK 176
VMENV ++ + + + F GY + +L+A D+G PQ+R RV K K
Sbjct: 120 VMENVARLYTHNSGKTRIEIIQAFQNIGYSVECKILSAADFGVPQIRSRVIFIGRRDKGK 179
Query: 177 KIKGP-------RKVWDALKNIPIDAP--------NHDFWSPPSKIARRIPRLRWGEGAQ 221
I P + V A+ + P A NH+ + +++ ++ ++ G
Sbjct: 180 -ISFPEPLQISHQTVGSAIGHFPKLAAGESNPHVANHEAMNHSAQMLEKMAFVKNGGNRN 238
Query: 222 --------RFGRFQNWIRLHPYKPAPTVRGNSRFVHPFE-DRPLTVREQARLMGFPDDFV 272
+ G + +IR + KPA + G+ R V +E +R LTVRE A L FPD+F+
Sbjct: 239 DIPEPLRPKTGDIRKYIRYNSNKPAVCITGDMRKVFHYEQNRALTVRELAALQSFPDNFI 298
Query: 273 FLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLSKE 307
F G + Q VG AVPP LAKAIA I + E
Sbjct: 299 FCGSKIAQQQQVGNAVPPLLAKAIAESILKMSENE 333
>emb|CAA74996.1| (Y14683) Bpu10I (5m)cytosine-specific DNA modification
methyltransferase (C1) [Bacillus pumilus]
Length = 398
Score = 150 bits (375), Expect = 2e-35
Identities = 121/402 (30%), Positives = 180/402 (44%), Gaps = 110/402 (27%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP 64
NK++ +DLFAGAGG SLGF+ GFEI A+E TY N VI DI I
Sbjct: 5 NKKVSPIDLFAGAGGMSLGFENAGFEIPLAVEIDDWAVDTYRKNRENSNVIKNDILEIDN 64
Query: 65 ---DEIGDVDVIIGGPPCEPF--TAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
+ +D +IGGPPC+ F +A N R ++P++ LYR +F+R ++ +KP+
Sbjct: 65 AFFKQFSGIDAVIGGPPCQGFSISASNRRNPDDPRNYLYR--------QFLRVIKLVKPR 116
Query: 120 VFVMENVPQIMEL----EKYLRKE----FDKAGYDIYFNVLNALDYGAPQVRRRVF-ISN 170
+ MENV +I++ K L E ++ GY I ++NA D+G PQ R R F +++
Sbjct: 117 IVFMENVKEIVKFVLPNGKLLLDEIIFCLEELGYSIKPFIINAADFGIPQERIRFFMVAS 176
Query: 171 LE-----------------LKPKKIKGPRKVWDALKNIPIDAPNH-------DFWSPP-- 204
L L+P K R V+ A+ ++P P ++ + P
Sbjct: 177 LGPVPDLLQEATYSETVDLLRPNKY---RDVYSAISDLPAVYPRQHEEGDTFEYDNQPVN 233
Query: 205 ----------SKIARRIPRLRWGEGAQRFGRFQ--------------------------- 227
+ I IP ++F +
Sbjct: 234 NYQRLMRKGSANIYNHIPMRHTDRTIEKFKMIRTQGIDSLPENLRSRTRGDSSKISNKTY 293
Query: 228 --NWIRLHPYKPAPTVRGN--SRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNV---- 279
N R++P KP+PT+ + S F+HP++DR LTVRE AR+ FPD+++F G R
Sbjct: 294 SQNHRRINPTKPSPTITASFYSSFIHPYQDRNLTVREAARIQSFPDNYIFYGKRTTLSKK 353
Query: 280 --------------QFDSVGEAVPPPLAKAIANFIFDVLSKE 307
QF+ VG AVPP LA+ A+ I L E
Sbjct: 354 LLEKKGIFEDVHLDQFNQVGNAVPPLLAEKFASIIIQSLKGE 395
>sp|P34906|MTF1_FUSNU MODIFICATION METHYLASE FNUDI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
FNUDI) (M.FNUDI) >gi|2961231|gb|AAC05695.1| (AF051374)
FnuDI DNA modification methyltransferase [Fusobacterium
nucleatum]
Length = 344
Score = 146 bits (364), Expect = 4e-34
Identities = 121/343 (35%), Positives = 170/343 (49%), Gaps = 51/343 (14%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
MK+L LF+GAGG LGF+ GFEI+ A E K +TY N K+I +DI+ I +E+
Sbjct: 1 MKLLSLFSGAGGLDLGFERAGFEIIVANEYDKTIWETYEKNHK-AKLIKKDIREILSEEL 59
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
D IIGGPPC+ ++ R N DP G+L E++R ++ ++PK F+ ENV
Sbjct: 60 PKSDGIIGGPPCQSWSEAGSLRGIN-------DPRGKLFYEYIRILKDIQPKFFLAENVK 112
Query: 128 QIM-----ELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF---------ISNLEL 173
++ E K + KEF++AGY+++ +LNA DYG Q R RVF ISN E
Sbjct: 113 GMLSKRNTEAVKDIIKEFEEAGYNVFIKLLNAFDYGVAQDRERVFYVGFRKDLNISNFEF 172
Query: 174 KPKKIKGPRK-----VWDALKNI------------PIDAPNHDFWSPP-SKIARRIPRLR 215
+ RK +WD N NH++ + S I R+R
Sbjct: 173 PYPISEKERKYLKDSIWDLKDNALPGKDKNKTNADDCIVENHEYLTGSYSTIFMSRNRVR 232
Query: 216 -WGEGAQRFGRFQNWIRLHPYKPAPTV----RGNSRFVHPFED--RPLTVREQARLMGFP 268
W + A +LHP APT+ + +FV E+ R L++RE AR+ GFP
Sbjct: 233 QWEQPAFTVQASGRQCQLHP--QAPTMIKIDKNMYKFVAGKENLYRRLSIRECARIQGFP 290
Query: 269 DDFVF-LGGRNVQFDSVGEAVPPPLAKAIANFIFDVLS-KERI 309
D F F + VG AVP LA IA I + L+ KE+I
Sbjct: 291 DTFKFYYTSLEDGYKMVGNAVPVDLAYIIAKRIKETLTDKEKI 333
>gb|AAC97190.1| (AF056036) modification methylase M.NspI [Nostoc ATCC29411]
Length = 397
Score = 145 bits (363), Expect = 5e-34
Identities = 103/326 (31%), Positives = 163/326 (49%), Gaps = 43/326 (13%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP----DE 66
+DLF GAGG + G GF+ +A++E + T+ NFP DI+ P +
Sbjct: 63 VDLFCGAGGITQGLVQAGFQALASVEISPIASATHQRNFPHCHHFWGDIEQFYPKSWLQQ 122
Query: 67 IG--DVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVME 124
IG +V++++GGPPC+ F+ R ++P++RL+ EFVR V ++P VME
Sbjct: 123 IGYPEVNLVVGGPPCQGFSVAGKRDPKDPRNRLF--------YEFVRVVSEIRPWYVVME 174
Query: 125 NVPQIMELEKYLRKE-----FDKAGYD-IYFNVLNALDYGAPQVR-RRVFISN------- 170
NVP I+ ++ K+ F+ GY + +L + DYG PQ+R R +FI+N
Sbjct: 175 NVPGILTIQNGNVKQAIIEAFESIGYPHVSVAILESADYGVPQIRPRAIFIANRFGMPNP 234
Query: 171 ---LELKPKKIKGPRK-VWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRF 226
+L P++ K + D + PI NH + + RI ++ G +
Sbjct: 235 YPKAQLLPEEYKPIESAISDLPEYTPIPEINHQWTRHSPEYMERIAKVPPGGSL-----Y 289
Query: 227 QNWI----RLHPYKPAPTVRGN--SRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQ 280
Q ++ R +P KP+ TV+ N +HP+ +R ++ RE ARL FPD F+F G
Sbjct: 290 QKYVDAFKRQYPGKPSMTVKENHGGTHIHPYLNRVISSREMARLQSFPDSFIFEGTMKKA 349
Query: 281 FDSVGEAVPPPLAKAIANFIFDVLSK 306
+G AVPP LA+ I + L+K
Sbjct: 350 MWQIGNAVPPRLAECIGYALIPYLNK 375
>pir||C71933 type II DNA modification enzyme (methyltransferase) - Helicobacter
pylori (strain J99) >gi|4154963|gb|AAD06007.1|
(AE001477) TYPE II DNA MODIFICATION ENZYME
(METHYLTRANSFERASE) [Helicobacter pylori J99]
Length = 351
Score = 145 bits (361), Expect = 9e-34
Identities = 107/358 (29%), Positives = 170/358 (46%), Gaps = 66/358 (18%)
Query: 9 KVLDLFAGAGGFSLGFKLVG-FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
KV D+F GAGG S GF FE++ A + K +Y N + I DI + +
Sbjct: 3 KVADIFCGAGGLSYGFSTHPYFELIWANDIDKDAILSYQANHKETQTILCDIAQLHCHNL 62
Query: 68 GDV--DVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
V D+++GGPPC+ ++ + +RK + K L++ E++R ++ +KPK+FV EN
Sbjct: 63 PRVPIDILLGGPPCQSYSTLG-KRKMDEKANLFK--------EYLRILDLVKPKIFVFEN 113
Query: 126 VPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF----ISNLELK-- 174
V +M ++K + F + GY + +LNALDYG PQVR RV + + + K
Sbjct: 114 VVGLMSMQKGQLFQRICNAFKERGYILEHAILNALDYGVPQVRERVILVGALKSFKQKFY 173
Query: 175 -PKKIKGPRKVWDALKNIP----------------------------IDAPNHDFWSPPS 205
PK IK + DAL ++P + H
Sbjct: 174 FPKPIKTHFSLKDALGDLPPIQSGENGDALGYLKNADNVFLEFVRNSKELSEHSSPKNNE 233
Query: 206 KIARRIPRLRWGEGAQ--------RFGRFQNWIRLHPYKPAPTVRGN------SRFVHPF 251
K+ + + L+ G+ + G + ++ KPAPT+ N SR +HP
Sbjct: 234 KLIKIMQTLKDGQSKDDLPESLRPKSGYINTYAKMWWEKPAPTITRNFSTPSSSRCIHPR 293
Query: 252 EDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLSKERI 309
+ R L++RE ARL FPD++ F G N + +G AVPP L+ A+A+ +FD L + +
Sbjct: 294 DSRALSIREGARLQSFPDNYKFYGSANAKRLQIGNAVPPLLSAALAHAVFDFLRGKNV 351
>gi|10954474 TIM [Methanobacterium thermoautotrophicum]
>gi|266583|sp|P29567|MTHT_METTF MODIFICATION METHYLASE
MTHTI (CYTOSINE-SPECIFIC METHYLTRANSFERASE MTHTI)
(M.MTHTI) >gi|282632|pir||B42941 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
MthTI - Methanobacterium thermoformicicum plasmid
>gi|44641|emb|CAA48436.1| (X68366) TIM [Methanobacterium
thermoautotrophicum] >gi|149743|gb|AAA73370.1| (M97222)
TIM [Methanobacterium thermoformicicum]
Length = 330
Score = 138 bits (344), Expect = 9e-32
Identities = 109/328 (33%), Positives = 154/328 (46%), Gaps = 44/328 (13%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
M + F+GAGG LGF GF IV A +N+K KT+ N G+K+ + I+ + P EI
Sbjct: 3 MDIASFFSGAGGLDLGFTKAGFNIVFANDNWKGCWKTFEKNH-GIKINKKPIEWLKPSEI 61
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
DV IGGPPC+ ++ + DP G+ +V V+ P F+ ENVP
Sbjct: 62 PDVVGFIGGPPCQSWSLAGSMCGAD-------DPRGKTFYAYVDLVKEKDPLFFLAENVP 114
Query: 128 QIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI----SNLELK---P 175
I+ K L F GY++ + VLNA DYG PQ R+RVFI +L LK P
Sbjct: 115 GIVSRTHLPEFKRLVNSFIDIGYNVEYKVLNAKDYGVPQDRKRVFIVGYREDLNLKFEFP 174
Query: 176 KKIKGPRKVWDALKNIP---------------IDAPNHDFWSP--PSKIARRIPRLRWGE 218
K + + DA+ ++P ++ PNH++ + S+ R W E
Sbjct: 175 KPLNKKVTLRDAIGDLPEPKPALEKNRSNGENLEVPNHEYMTGTFSSRYMSRNRVRSWDE 234
Query: 219 GAQRFGRFQNWIRLHPYKPAPTVRGNSRFV----HPFEDRPLTVREQARLMGFPDDFVFL 274
+ HP G +F+ P R L+VRE AR+ GFPDDF+F
Sbjct: 235 VSFTIQAGGRHAPCHPQANKMIKVGPDKFIFDPESPKPYRRLSVRECARIQGFPDDFIFY 294
Query: 275 GGRNVQ--FDSVGEAVPPPLAKAIANFI 300
+NV + VG AVP LA+ +A I
Sbjct: 295 -YKNVADGYTMVGNAVPVKLAEELAKKI 321
>emb|CAA74997.1| (Y14683) Bpu10I (5m)cytosine-specific DNA modification
methyltransferase (C2) [Bacillus pumilus]
Length = 392
Score = 137 bits (342), Expect = 2e-31
Identities = 119/391 (30%), Positives = 170/391 (43%), Gaps = 99/391 (25%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI--- 67
LDLF+GAGGF+LG K G + + AIE + ++T+ NFP + +I EI
Sbjct: 5 LDLFSGAGGFTLGLKNAGIKTIGAIELDRFASETFRKNFPEIPHYQANITEYGDSEIIKL 64
Query: 68 -GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
VD+I GGPPC+ F+ P + +R L++E RF LKP + ++ENV
Sbjct: 65 FKGVDIITGGPPCQGFSVAGPSQYGIIDNR------NNLIMEMYRFASILKPNLVILENV 118
Query: 127 PQIME---------LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI---SNLELK 174
I+ L++Y+ GY I VLN D+G PQ R+RVF+ N
Sbjct: 119 KGILNGKLSPTKKALDEYM-NNMSNIGYKIKVFVLNTSDFGVPQGRQRVFVIAARNEAFI 177
Query: 175 PKKI--------KGPRKVWDALKNIPI--------DAPNHDF--------WSPPSKI--- 207
P +I K R V +AL+++P+ DA + F W I
Sbjct: 178 PLEIIGEYTQGKKAKRTVGEALEDLPLIDSGEGVEDAVTYPFEAKTDYQKWLREGSIGVY 237
Query: 208 -------ARRI---------------------PRLRWGEGAQRFGRFQ-NWIRLHP--YK 236
+R+ R R G+ RF+ N RL+P
Sbjct: 238 NHVAMKHTKRLIERFKHIDIGQSLKDVNPEHGQRARNGQELDVRKRFKMNNQRLNPLGIS 297
Query: 237 PAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNV----------------- 279
A T S F+HP+ +R LT RE ARL FPD F+F G R +
Sbjct: 298 TAITASFQSNFIHPYLNRNLTAREGARLQSFPDKFIFCGPRTLMSKKLLEREGRLDEIGL 357
Query: 280 -QFDSVGEAVPPPLAKAIANFIFDVLSKERI 309
Q++ +G AVPP LA+AI + D L+K +
Sbjct: 358 SQYNQIGNAVPPLLAEAIGKTVLDSLNKSSL 388
>sp|P23737|MTS9_STAAU MODIFICATION METHYLASE SAU96I (CYTOSINE-SPECIFIC METHYLTRANSFERASE
SAU96I) (M.SAU96I) >gi|97849|pir||S12705 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
Sau96I - Staphylococcus aureus
>gi|581567|emb|CAA37260.1| (X53096) Sau96I DNA
methyltransferase [Staphylococcus aureus]
Length = 430
Score = 134 bits (334), Expect = 1e-30
Identities = 104/341 (30%), Positives = 159/341 (46%), Gaps = 47/341 (13%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP 64
NK V + FAGAGG +LG + G A+E K A+T N P KVI DI+ I+
Sbjct: 96 NKDYNVFETFAGAGGLALGLESAGLSTYGAVEIDKNAAETLRINRPKWKVIENDIEFIAD 155
Query: 65 --DEIGD--VDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV 120
DE D +D++ GG PC+ F+ R + D G L + + + +LKPK
Sbjct: 156 NLDEFIDEEIDILSGGYPCQTFSYAGKRNG-------FADTRGTLFYPYSKILSKLKPKA 208
Query: 121 FVMENVPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNL-ELK 174
F+ ENV ++ + + + K F K GY++Y+N+LN+ +Y Q R R+ I + E
Sbjct: 209 FIAENVRGLVNHDDGKTLEVMLKVFIKEGYEVYWNILNSWNYDVAQKRERIVIIGIREDL 268
Query: 175 PKKIKGPRK----------VWDALKNIP----------------IDAPNHDFWSPPSKIA 208
K+ K P + + D LK++P + P + P +IA
Sbjct: 269 VKEQKYPFRFPLAQVYKPVLKDVLKDVPKSKVTAYSDKKREVMKLVPPGGCWVDLPEQIA 328
Query: 209 RRIPRLRW--GEGAQRFGRFQNWIR-LHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLM 265
+ W G G + R +W +P+ + R HP E RP ++RE AR+
Sbjct: 329 KDYMGKSWYSGGGKRGMARRISWDEPCLTLTTSPSQKQTER-CHPDETRPFSIREYARIQ 387
Query: 266 GFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLSK 306
FPD++ F GG Q+ +G AVP LAK I + L++
Sbjct: 388 SFPDEWEFSGGVGAQYRQIGNAVPVNLAKYIGKSLVHYLNQ 428
>sp|P08455|MTP2_NEIGO MODIFICATION METHYLASE NGOPII (CYTOSINE-SPECIFIC METHYLTRANSFERASE
NGOPII) (M.NGOPII)
Length = 330
Score = 131 bits (326), Expect = 1e-29
Identities = 112/337 (33%), Positives = 158/337 (46%), Gaps = 45/337 (13%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
MK++ LF+G GG LGF+ GFEI AA E K T+ N P +I DI+ I ++
Sbjct: 1 MKIISLFSGCGGLDLGFEKAGFEIPAANEYDKTIWATFKANHPKTHLIEGDIRKIKEEDF 60
Query: 68 -GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
++D IIGGPPC+ ++ R + D G+L +++R ++ +PK F+ ENV
Sbjct: 61 PEEIDGIIGGPPCQSWSEAGALRGID-------DARGQLFFDYIRILKSKQPKFFLAENV 113
Query: 127 PQIME-----LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI----SNLELK--- 174
++ + L K FD GYD+ + NA DYG Q R+RVF +LE+K
Sbjct: 114 SGMLANRHNGAVQNLLKMFDGCGYDVTLTMANAKDYGVAQERKRVFYIGFRKDLEIKFSF 173
Query: 175 PK--------KIKGPRKVWD----ALKNIPIDAPNHD-------FWSPPSKIARRIPRLR 215
PK KI +WD A+ + P + N D F S I R++
Sbjct: 174 PKGSTVEDKDKITLKDVIWDLQDTAVPSAPQNKTNPDAVNNNEYFTGSFSPIFMSRNRVK 233
Query: 216 -WGEGAQRFGRFQNWIRLHPYKPAPTVRG--NSRFVHPFED--RPLTVREQARLMGFPDD 270
W E +LHP P G + RF E R +TVRE AR+ GFPD+
Sbjct: 234 AWDEQGFTVQASGRQCQLHPQAPKMEKHGANDYRFAAGKETLYRRMTVREVARIQGFPDN 293
Query: 271 FVFL-GGRNVQFDSVGEAVPPPLAKAIANFIFDVLSK 306
F F+ N + +G AVP LA IA I L +
Sbjct: 294 FKFIYQNVNDAYKMIGNAVPVNLAYEIAAAIKKTLER 330
>pir||CTNHP2 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) NgoPII - Neisseria gonorrhoeae
>gi|44873|emb|CAA30038.1| (X06965) NgoPII methylase (AA
1-341) [Neisseria gonorrhoeae] >gi|44888|emb|CAA36888.1|
(X52661) NgoPII restriction and modification [Neisseria
gonorrhoeae] >gi|293960|gb|AAA17019.1| (L14564) cytosine
methylase [Neisseria gonorrhoeae]
>gi|227054|prf||1613419B NgoPII methylase [Neisseria
gonorrhoeae]
Length = 341
Score = 131 bits (326), Expect = 1e-29
Identities = 112/337 (33%), Positives = 158/337 (46%), Gaps = 45/337 (13%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
MK++ LF+G GG LGF+ GFEI AA E K T+ N P +I DI+ I ++
Sbjct: 12 MKIISLFSGCGGLDLGFEKAGFEIPAANEYDKTIWATFKANHPKTHLIEGDIRKIKEEDF 71
Query: 68 -GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
++D IIGGPPC+ ++ R + D G+L +++R ++ +PK F+ ENV
Sbjct: 72 PEEIDGIIGGPPCQSWSEAGALRGID-------DARGQLFFDYIRILKSKQPKFFLAENV 124
Query: 127 PQIME-----LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI----SNLELK--- 174
++ + L K FD GYD+ + NA DYG Q R+RVF +LE+K
Sbjct: 125 SGMLANRHNGAVQNLLKMFDGCGYDVTLTMANAKDYGVAQERKRVFYIGFRKDLEIKFSF 184
Query: 175 PK--------KIKGPRKVWD----ALKNIPIDAPNHD-------FWSPPSKIARRIPRLR 215
PK KI +WD A+ + P + N D F S I R++
Sbjct: 185 PKGSTVEDKDKITLKDVIWDLQDTAVPSAPQNKTNPDAVNNNEYFTGSFSPIFMSRNRVK 244
Query: 216 -WGEGAQRFGRFQNWIRLHPYKPAPTVRG--NSRFVHPFED--RPLTVREQARLMGFPDD 270
W E +LHP P G + RF E R +TVRE AR+ GFPD+
Sbjct: 245 AWDEQGFTVQASGRQCQLHPQAPKMEKHGANDYRFAAGKETLYRRMTVREVARIQGFPDN 304
Query: 271 FVFL-GGRNVQFDSVGEAVPPPLAKAIANFIFDVLSK 306
F F+ N + +G AVP LA IA I L +
Sbjct: 305 FKFIYQNVNDAYKMIGNAVPVNLAYEIAAAIKKTLER 341
>gb|AAB03209.1| (U42460) NgoII cytosine methylase M.NgoII [Neisseria gonorrhoeae]
Length = 341
Score = 130 bits (324), Expect = 2e-29
Identities = 111/337 (32%), Positives = 154/337 (44%), Gaps = 45/337 (13%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
MK++ LF+G GG LGF+ GFEI AA E K T+ N P +I DI+ I ++
Sbjct: 12 MKIISLFSGCGGLDLGFEKAGFEIPAANEYDKTIWATFKANHPKTHLIEGDIRKIKEEDF 71
Query: 68 -GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
++D IIGGPPC+ ++ R + D G+L +++R ++ +PK F+ ENV
Sbjct: 72 PEEIDGIIGGPPCQSWSEAGALRGID-------DARGQLFFDYIRILKSKQPKFFLAENV 124
Query: 127 PQIME-----LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI----SNLELK--- 174
++ + L K FD GYD+ + NA DYG Q R+RVF +LE+K
Sbjct: 125 SGMLANRHNGAVQNLLKMFDGCGYDVTLTMANAKDYGVAQERKRVFYIGFRKDLEIKFSF 184
Query: 175 PK--------KIKGPRKVWDALKNIPIDAP-----------NHDFWSPPSKIARRIPRLR 215
PK KI +WD AP N F S I R++
Sbjct: 185 PKGSTVEDKDKITLKDVIWDLQDTAVPSAPQNKTKPDAVNNNEYFTGSFSPIFMSRNRVK 244
Query: 216 -WGEGAQRFGRFQNWIRLHPYKPAPTVRG--NSRFVHPFED--RPLTVREQARLMGFPDD 270
W E +LHP P G + RF E R +TVRE AR+ GFPD+
Sbjct: 245 AWDEQGFTVQASGRQCQLHPQAPKMEKHGANDYRFAAGKETLYRRMTVREVARIQGFPDN 304
Query: 271 FVFL-GGRNVQFDSVGEAVPPPLAKAIANFIFDVLSK 306
F F+ N + +G AVP LA IA I L +
Sbjct: 305 FKFIYQNVNDAYKMIGNAVPVNLAYEIAAAIKKTLER 341
>dbj|BAB07227.1| (AP001519) cytosine-specific methyltransferase [Bacillus
halodurans]
Length = 326
Score = 130 bits (323), Expect = 3e-29
Identities = 89/312 (28%), Positives = 153/312 (48%), Gaps = 25/312 (8%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIGDV 70
+ LF+GAGG +GF+ +GF+I+ A + + T+ + +V+ DI I I
Sbjct: 9 VSLFSGAGGLDMGFERIGFKIIWANDIDEDACATH-RLWSDAEVVQGDISKIDVSTIPSA 67
Query: 71 DVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQIM 130
D+++GG PC+ F+ PR+ ++ ++ LY+ +V+++E KP FV ENV ++
Sbjct: 68 DILLGGWPCQGFSLAGPRQLDDSRNTLYK--------YYVKYLEEKKPLAFVGENVKGML 119
Query: 131 -----ELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNL--ELKPKKIKGPRK 183
E+ K + + DK GY +++ +LNA DY PQ R RV I +L + P K
Sbjct: 120 TLGNGEIFKAIISDMDKKGYTLFYKLLNAKDYSVPQNRERVIIVGFRNDLGITEFTFPEK 179
Query: 184 ------VWDALKNIPIDAPNHDFWSP-PSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYK 236
+ +AL ++P +P +P S+ R + W E + + LHP
Sbjct: 180 HDKIVTLREALADLPEPSPEDICDAPYSSRFMSRNRKRNWDEVSYTIPAMAKQVPLHPSS 239
Query: 237 PAPTVRGNS--RFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAK 294
P G +F R + +E A + FP D F+G ++ +G AVP LA+
Sbjct: 240 PDMVKLGKDLWKFGENGVTRRFSWQEAAAIQTFPRDMHFVGELTSKYKQIGNAVPVKLAE 299
Query: 295 AIANFIFDVLSK 306
A+A +++ L++
Sbjct: 300 AVAEKVYEKLNE 311
>gb|AAB84141.1| (AF029070) FauI DNA methyltransferase [Flavobacterium aquatile]
Length = 343
Score = 130 bits (323), Expect = 3e-29
Identities = 97/332 (29%), Positives = 155/332 (46%), Gaps = 44/332 (13%)
Query: 4 GNKRMKVLDLFAGAGGFSLG-----------FKLVGFEIVAAIENFKPKAKTYSHNFPGV 52
GN ++KV LF G GG +G + + F++V A++N K Y+ NF
Sbjct: 6 GNSKLKVASLFCGCGGMDVGIQGDFKFLKKHYDTLPFKVVYAVDNDAYATKIYNDNFAH- 64
Query: 53 KVIAQDIKVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRF 112
K +D++ I P E+ D D+++GG PC+ F+ +NP Y+D G+L E ++
Sbjct: 65 KCETKDVRDIVPSEVPDHDILLGGFPCQSFSI----SAQNPPRLGYKDDRGKLFFEMIKV 120
Query: 113 VERLKPKVFVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF 167
++ KP+ F+ ENV ++ K + KEF+KAGY I + +LN+ ++G PQ R RVF
Sbjct: 121 LKEKKPRFFIGENVKGLLSANKGQAFPMIIKEFEKAGYHINYKLLNSSEFGVPQKRERVF 180
Query: 168 ISNLE----------LKPKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWG 217
I +P ++G + V + + D F+S + R +
Sbjct: 181 IVGFRDFDDYLNFKFPQPITLEGSKIVLKEVIDKKADTEEKWFFSQKAVDGMLRVREKMN 240
Query: 218 EG-AQRFGRFQNWIRLHPYKPA-----PTVRGNSRFVHPFEDRPLTVREQARLMGFPDDF 271
+G Q + N I H K + P + N R+ R LT RE A + FP F
Sbjct: 241 KGRVQDLNQPCNTISSHLAKVSLNGTDPVLMVNERY------RRLTPREAANIQSFPQSF 294
Query: 272 VFLG-GRNVQFDSVGEAVPPPLAKAIANFIFD 302
N Q+ ++G AVPP L +AN + +
Sbjct: 295 KLDSVSENRQYKAIGNAVPPVLMWNVANALIE 326
>gb|AAB59071.1| (L14563) cytosine methylase [Neisseria gonorrhoeae]
Length = 341
Score = 128 bits (319), Expect = 8e-29
Identities = 111/337 (32%), Positives = 157/337 (45%), Gaps = 45/337 (13%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
MK++ LF+G GG LGF+ GFEI AA E K T+ N P +I DI+ I ++
Sbjct: 12 MKIISLFSGCGGLDLGFEKAGFEIPAANEYDKTIWATFKANHPKTHLIEGDIRKIKEEDF 71
Query: 68 -GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
++D IIGGPPC+ ++ R + D G+L +++R ++ +PK F+ ENV
Sbjct: 72 PEEIDGIIGGPPCQSWSEAGALRGID-------DARGQLFFDYIRILKSKQPKFFLAENV 124
Query: 127 PQIME-----LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI----SNLELK--- 174
++ + L K FD GYD+ + NA DYG Q R+RVF +LE+K
Sbjct: 125 SGMLANRHNGAVQNLLKMFDGCGYDVTLTMANAKDYGVAQERKRVFYIGFRKDLEIKFSF 184
Query: 175 PK--------KIKGPRKVWD----ALKNIPIDAPNHD-------FWSPPSKIARRIPRLR 215
PK KI +WD A+ + P + N D F S I R++
Sbjct: 185 PKGSTVEDKDKITLKDVIWDLQDTAVPSAPQNKTNPDAVNNNEYFTGSFSPIFMSRNRVK 244
Query: 216 -WGEGAQRFGRFQNWIRLHPYKPAPTVRG--NSRFVHPFEDR--PLTVREQARLMGFPDD 270
W E +LHP P G + RF E +TVRE AR+ GFPD+
Sbjct: 245 AWDEQGFTVQASGRQCQLHPQAPKMEKHGANDYRFAAGKETLYWRMTVREVARIQGFPDN 304
Query: 271 FVFL-GGRNVQFDSVGEAVPPPLAKAIANFIFDVLSK 306
F F+ N + +G AVP LA IA I L +
Sbjct: 305 FKFIYQNVNDAYKMIGNAVPVNLAYEIAAAIKKTLER 341
>gb|AAF06965.1|AF157599_4 (AF157599) EcoO109IM [Escherichia coli]
Length = 414
Score = 126 bits (314), Expect = 3e-28
Identities = 106/376 (28%), Positives = 155/376 (41%), Gaps = 92/376 (24%)
Query: 9 KVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI- 67
K + LF+GA G LG + GFE+VA +E K KT N P + V I + E+
Sbjct: 5 KFISLFSGAMGLDLGLEEAGFELVACVEQDKAALKTIKTNKPNLAVFEGSIVDCTGSELL 64
Query: 68 --------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
++D++ GGPPC+ F+ R D G+L+ E+VR ++ L PK
Sbjct: 65 ALAGVNDKEEIDLVAGGPPCQAFSVFGNRLG-------LEDARGQLIFEYVRMIKELNPK 117
Query: 120 VFVMENVPQIMELE-------------------------KYLRKEFDKAGYDIYFNVLNA 154
VFVMENV ++ + K + EF+K GY + V+NA
Sbjct: 118 VFVMENVRGLLSMSIVPASKKKELSGTIAASAFEKGSLIKRVANEFNKLGYHVDCFVVNA 177
Query: 155 LDYGAPQVRRRV--------FISNL-----------ELKPKKIKG--------------- 180
+YGAPQ+R RV I+N L P K G
Sbjct: 178 ANYGAPQIRERVILIGNRFGMIANFASPLFSNRVEDNLPPFKTLGDVIGPESGFVDKYPE 237
Query: 181 -----PRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPY 235
PRK LK + + P ++ S P ++ + W + GR W +L
Sbjct: 238 VMNFSPRK----LKYLSMVPPGGNWRSMPEEMQKESMGKSW---YLKGGRSAYWRKLSFQ 290
Query: 236 KPAPTV-----RGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPP 290
P+PTV + HP E R ++V E A + FPD + F G +F +G AVP
Sbjct: 291 FPSPTVVTMPNHAGTSMCHPTELRAISVGEAAAIQEFPDYWKFEGTTTEKFRQIGNAVPV 350
Query: 291 PLAKAIANFIFDVLSK 306
L K ++L +
Sbjct: 351 RLGKVAGEAAMELLHR 366
>sp|Q59606|MTF7_NEIGO MODIFICATION METHYLASE NGOFVII (CYTOSINE-SPECIFIC METHYLTRANSFERASE
NGOFVII) (M.NGOFVII) >gi|7433515|pir||T10165
site-specific DNA-methyltransferase (cytosine-specific)
(EC 2.1.1.73) NgoVII - Neisseria gonorrhoeae
>gi|1165245|gb|AAA86270.1| (U43736) M.NgoVII [Neisseria
gonorrhoeae]
Length = 374
Score = 125 bits (312), Expect = 5e-28
Identities = 102/349 (29%), Positives = 152/349 (43%), Gaps = 59/349 (16%)
Query: 1 MGEGNKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIK 60
+ + + K+L LF+G GG LGF G E V A + +++ N V ++ DI+
Sbjct: 9 LNSSSNKPKILSLFSGCGGLDLGFHQAGCETVWANDFSHWACESFRKNIGDV-IVEGDIE 67
Query: 61 VISPDE--IGDVDVIIGGPPCEPFTAI-NPRRKENPKDRLYRDPIGRLVLEFVRFVERLK 117
I+P++ I D D+I+GG PC+ F+ I E + LY+ F+RFV K
Sbjct: 68 QINPNDPTIPDCDIILGGFPCQDFSMIWKQPGLEGERGNLYKS--------FLRFVNAKK 119
Query: 118 PKVFVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLE 172
PKVFV ENV ++ K + +F+ GY + NV N ++G PQ R RV I +
Sbjct: 120 PKVFVAENVKGLLTANKKKAIQQIITDFENCGYYVQANVYNFAEFGVPQFRERVLIVGVR 179
Query: 173 LKP----------------KKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRW 216
L +K A+ NIP +A N++ K R + +
Sbjct: 180 LDTGFDFRHPEPTHNETGENGLKPYVTAGQAISNIPQNASNNELLKISDKTRRMLELIPE 239
Query: 217 GEGAQRFGRFQN----------------WIRLHPYKPAPTV----RGNSRFVHPFEDRPL 256
G G F + + R+H +P+ T+ G + H E R
Sbjct: 240 G------GNFTDIPKDHPLYVKGMISHVYRRMHRNEPSKTIIAAGGGGTWGYHFPEPRAF 293
Query: 257 TVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLS 305
T RE+ARL FPDDF F+G +G AVPP +A I + S
Sbjct: 294 TNRERARLQSFPDDFEFVGSTTEVRRQIGNAVPPQGVVELAKSILPIFS 342
>pir||F81959 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) NMA0427 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7379177|emb|CAB83726.1|
(AL162753) modification methylase (cytosine-specific DNA
methylase) [Neisseria meningitidis Z2491]
Length = 351
Score = 124 bits (308), Expect = 1e-27
Identities = 110/354 (31%), Positives = 162/354 (45%), Gaps = 65/354 (18%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAK-TYSHNFPGVKVIAQDIKVIS 63
N ++K +D F G GG S G + G +++A I+ ++P K TY N K I D+ +
Sbjct: 3 NSKLKAVDFFCGGGGMSYGMQSAGIQVLAGID-YEPSCKETYEANI-NAKFIQADVFELQ 60
Query: 64 PD----EIG-----DVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVE 114
P+ E+G D ++IG PC+ ++ I ++++ K + L+LEF RFVE
Sbjct: 61 PETLEKELGLKKNDDDLILIGCSPCQYWSVIQTDKRKSEKSK-------SLLLEFQRFVE 113
Query: 115 RLKPKVFVMENVPQIMELEKYLR-----KEFDKAGYDIYFNVLNALDYGAPQVRRRVF-- 167
P V+ENVP I+ K R K ++ G+ ++F + N DYG PQ R+R
Sbjct: 114 YFNPGYVVVENVPGILSRMKESRLDNFIKLLEEKGFTVHFGIHNTADYGIPQSRKRFTLI 173
Query: 168 ---ISNLELKPKKIKGPR-KVWDAL-------KNIPIDAPNHDFWSPPSKIA-------- 208
I+ +L+P K G R V D L K I DF + ++
Sbjct: 174 ANRITKEKLEPVKYSGKRLTVRDVLGMENGFPKIIAGHQDETDFMHSCAGLSDINLKRLA 233
Query: 209 ------------RRIPRLRWGEGAQRFGRFQNWI-RLHPYKPAPTVR------GNSRFVH 249
IP L+ + F++ RL KPAPT+ N RF H
Sbjct: 234 LIPKNGGNRLAFAHIPELQLECFIGKDNSFKDTFGRLWWDKPAPTITTKFFSISNGRFAH 293
Query: 250 PFEDRPLTVREQARLMGFPDDFVF-LGGRNVQFDSVGEAVPPPLAKAIANFIFD 302
P EDR L++RE A L FP ++VF G R+ +G AVPP A+ I I D
Sbjct: 294 PEEDRALSLREGATLQSFPRNYVFKAGSRDKIARLIGNAVPPMYAEKIGRAIVD 347
>pir||C64580 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) HP0483 - Helicobacter pylori (strain 26695)
Length = 328
Score = 121 bits (300), Expect = 1e-26
Identities = 91/332 (27%), Positives = 155/332 (46%), Gaps = 66/332 (19%)
Query: 29 FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD-EIGDVDVIIGGPPCEPFTAINP 87
FE++ A + K +Y N V ++ +++ + +D+++GGPPC+ ++ +
Sbjct: 5 FELIWANDIDKDAILSYQANHKEVTILCDIVQLHCHNLPCVSIDILLGGPPCQSYSTLG- 63
Query: 88 RRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQIMELEK-----YLRKEFDK 142
+RK + K L++ E++R ++ +KPK+FV ENV +M ++K + F +
Sbjct: 64 KRKMDEKANLFK--------EYLRLLDLVKPKIFVFENVVGLMSMQKGQLFKQICNAFKE 115
Query: 143 AGYDIYFNVLNALDYGAPQVRRRVFISNLELK--------PKKIKGPRKVWDALKNIP-- 192
Y + +LNALDYG PQ+R RV + + LK PK IK + DAL ++P
Sbjct: 116 RDYILEHAILNALDYGVPQMRERVILVGV-LKSFKQKFYFPKPIKTHFSLKDALGDLPPI 174
Query: 193 --------------------------IDAPNHDFWSPPSKIARRIPRLRWGEGAQ----- 221
+ H K+ + + L+ G+
Sbjct: 175 QSGENGDALGYLKNADNVFLEFVRNSKELSEHSSPKNNEKLIKIMQTLKDGQSKDDLPES 234
Query: 222 ---RFGRFQNWIRLHPYKPAPTVRGN------SRFVHPFEDRPLTVREQARLMGFPDDFV 272
+ G + ++ KPAPT+ N SR +HP + R L++RE ARL FPD++
Sbjct: 235 LRPKSGYINTYAKMWWEKPAPTITRNFSTPSSSRCIHPRDSRALSIREGARLQSFPDNYK 294
Query: 273 FLGGRNVQFDSVGEAVPPPLAKAIANFIFDVL 304
F G + + +G AVPP L+ A+A +FD L
Sbjct: 295 FCGSGSAKRLQIGNAVPPLLSVALAQAVFDFL 326
>pir||C64526 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) HP0051 - Helicobacter pylori (strain 26695)
>gi|2313124|gb|AAD07117.1| (AE000526) cytosine specific
DNA methyltransferase (DDEM) [Helicobacter pylori 26695]
Length = 355
Score = 121 bits (300), Expect = 1e-26
Identities = 102/362 (28%), Positives = 161/362 (44%), Gaps = 74/362 (20%)
Query: 9 KVLDLFAGAGGFSLGFK-LVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI-------K 60
K+LDLF GAGGFS G + L F+ + ++ K T+ +N + DI K
Sbjct: 4 KILDLFCGAGGFSAGLECLEEFDALIGLDCDKQALITFENNHKNAIGVCGDITQTEIKEK 63
Query: 61 VISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV 120
VI + ++++IIGGPPC+ F+ K+ +DP L LE++ V+ +KP++
Sbjct: 64 VIKLAKKLEINMIIGGPPCQGFS-------NKGKNLGLKDPRNFLFLEYIEIVKAIKPEI 116
Query: 121 FVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLE--- 172
F++ENV ++ K +++ + GY + + +LNA DYG PQ R R FI
Sbjct: 117 FIIENVKNLISCAKGYFLEEIKERLNALGYQLSYQILNAKDYGVPQNRERAFIVGASRFS 176
Query: 173 -----LKPKKIKGPRKVWDALKNI----------------PI----------DAP---NH 198
L+P + V DA+ ++ PI D+P NH
Sbjct: 177 FDFNLLEPSQ---SVNVQDAISDLAYLCSNEGAFESDYLNPIQSSYQALMRKDSPKLYNH 233
Query: 199 DFWSPPSKIARRIPRLRWGEGAQ-----RFGRFQ---NWIRLHPYKPAPTV------RGN 244
+ ++ + +G + G+ Q W RL+ K +PT+ N
Sbjct: 234 QATNHSQAALEKLKLINKEQGKECLPKNLHGKQQFKSTWGRLNWNKISPTIDTRFDTPSN 293
Query: 245 SRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVL 304
HP R +T RE AR+ F D+++F G + +G AVPP LA A+ I L
Sbjct: 294 GTNSHPELHRSITPREAARIQSFSDNYIFYGNKTSVCKQIGNAVPPLLALALGKAILKSL 353
Query: 305 SK 306
K
Sbjct: 354 RK 355
>sp|P52311|MTX2_XANOR MODIFICATION METHYLASE XORII (CYTOSINE-SPECIFIC METHYLTRANSFERASE
XORII) (M.XORII) >gi|1085999|pir||S46293 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
XorII - Xanthomonas oryzae pv. oryzae
>gi|458402|gb|AAA50432.1| (U06424) M-XorII [Xanthomonas
oryzae]
Length = 424
Score = 120 bits (299), Expect = 2e-26
Identities = 111/376 (29%), Positives = 158/376 (41%), Gaps = 94/376 (25%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI--- 67
+DLFAGAGG SLGF+ GF++VAA++ + NFP + + + ++ E+
Sbjct: 7 IDLFAGAGGLSLGFEQAGFDLVAAVDIDPIHCAAHKFNFPKCATVCKSVVDVTRSELRRI 66
Query: 68 -----GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFV 122
D+D++IGG PC+ F+ I R ++ ++ +LV +VR V LKPK FV
Sbjct: 67 AGIGKRDIDIVIGGAPCQGFSLIGKRALDDSRN--------QLVHHYVRVVMELKPKYFV 118
Query: 123 MENVPQI-----MELEKYLRKEFDKAGYDIY--FNVLNALDYGAPQVRRRVFISN----- 170
ENV + + K + + F GYD+ + VLNA DYG PQ RRR+ +
Sbjct: 119 FENVKGLTVGKHRQFLKEVIEAFQNGGYDVVTDYRVLNAADYGVPQDRRRLILMGARKGL 178
Query: 171 -LELKPKKIKGPRKVWDALKNIPIDAPNHDFW---------SPPSKIARRI--------- 211
L P+ G V DA+ +IP + W PS A +
Sbjct: 179 PLPAYPEP-TGRTTVGDAIGDIPDAESFPELWERDWVKAKYGKPSTYAAYLRGKKDDPTD 237
Query: 212 --------PRLRWGE--------GAQRF-----------GRFQ--------NWIRLHPYK 236
P L G QRF RF+ N +R
Sbjct: 238 FGYRRQFDPMLLTGSLLTDHTELSRQRFAAIAPDDVEPVSRFKKLALNGICNTLR----- 292
Query: 237 PAPTVRGNSRFVHPFEDRP-----LTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPP 291
A T F P P +TVRE ARL +PD F F + F +G +VPP
Sbjct: 293 -AGTASDRGAFTSPRPIHPTVPRVITVREAARLHSYPDWFRFHATKWHGFRQIGNSVPPL 351
Query: 292 LAKAIANFIFDVLSKE 307
LA+A+ I L K+
Sbjct: 352 LARAVGGQIMKALRKK 367
>emb|CAA68841.1| (Y07554) type II DNA m5C-methyltransferase [Psychrobacter sp.]
Length = 416
Score = 118 bits (294), Expect = 7e-26
Identities = 103/344 (29%), Positives = 143/344 (40%), Gaps = 48/344 (13%)
Query: 3 EGNKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVI 62
E ++ +++LFAGAGG +LG + GF+ V E K T N P VI DI+ +
Sbjct: 72 EPSRSYSLVELFAGAGGLALGLEQAGFKSVLLNEKDKYACATLRANRPNWNVIEDDIENV 131
Query: 63 SPDEI-GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVF 121
+ G VD++ GG PC+PF+ K + D G LV E R ++ +KPKVF
Sbjct: 132 DFTHLNGKVDLLTGGFPCQPFSYAG-------KQLGFEDLRGTLVFEMARAIKEIKPKVF 184
Query: 122 VMENVPQIMELE-----KYLRKEFDKAGYDIYFN-VLNALDYGAPQVRRRVFISNLEL-- 173
+ ENV + E + + K + GY I V A+ Y PQ R R+ I +
Sbjct: 185 LAENVKGLAENDGGRTLSIIIKVLEDLGYKILEKEVYKAIFYKVPQKRERLIIIGVRTDL 244
Query: 174 -------KPKKIKGPRKVWDALK----------------------NIPIDAPNHDFWSP- 203
KP V DALK I P +W
Sbjct: 245 YDKLAYEKPSPYYKVLTVADALKAGELYDVDVPESTGQLYPERKAEIMSYVPEGGYWRDL 304
Query: 204 PSKIARR--IPRLRWGEGAQRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQ 261
P +IA+ + G G R +W + + HP E RPLT RE
Sbjct: 305 PIRIAKEYMMKSFYLGGGKTGMARRLSWDEPSLTLVCTPAQKQTERCHPSESRPLTTREY 364
Query: 262 ARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLS 305
AR+ FPDD+ F G + +G AVP LA AI I +L+
Sbjct: 365 ARIQTFPDDWEFKGSVGQIYKQIGNAVPVNLALAIGKAIIRMLN 408
>sp|P06530|MTBR_BACSU MODIFICATION METHYLASE BSURI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
BSURI) (M.BSURI) >gi|66472|pir||XYBSR1 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
BsuRI - Bacillus subtilis (strain R)
>gi|40247|emb|CAA26731.1| (X02988) BsuRI methylase (aa
1-436) [Bacillus subtilis]
Length = 436
Score = 118 bits (292), Expect = 1e-25
Identities = 103/352 (29%), Positives = 155/352 (43%), Gaps = 69/352 (19%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGFEIV----AAIENFKPKAK------------------- 43
++ VL LF+G GG LGF+L G V AA+E FK K +
Sbjct: 58 KINVLSLFSGCGGLDLGFELAGLAAVIGEQAAMEAFKDKDRFNELRNKSIFHTIYTNDLF 117
Query: 44 -----TYSHNFPGVKVIAQDIKVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLY 98
TY NFPG VI + + ++I+GG PC F+ PR ++ ++ LY
Sbjct: 118 KEANQTYKTNFPG-HVIQHEKDIRQVKYFPKCNLILGGFPCPGFSEAGPRLIDDDRNFLY 176
Query: 99 RDPIGRLVLEFVRFVERLKPKVFVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLN 153
L F+R + + +P++FV ENV +M L K + ++F AGY + F +LN
Sbjct: 177 --------LHFIRSLIQAQPEIFVAENVKGMMTLGKGEVLNQIIEDFASAGYRVQFKLLN 228
Query: 154 ALDYGAPQVRRRVFISNLEL--------------KPKKIKGPRKVWDALKNIPIDAPNHD 199
A DYG PQ+R RV I + + +K + + D++ ++ D +
Sbjct: 229 ARDYGVPQLRERVIIEGVRKDISFNYKYPSPTHGEETGLKPFKTLRDSIGDLVTDPGPYF 288
Query: 200 FWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFED---RPL 256
S S R + W E + LHP + G ++V P + R L
Sbjct: 289 TGSYSSIYMSRNRKKSWDEQSFTIQASGRQAPLHPGGLSMKKIGKDKWVFPDGEENHRRL 348
Query: 257 TVREQARLMGFPDDFVFLGGRN----------VQFDSVGEAVPPPLAKAIAN 298
+V+E AR+ FPD F F G N Q+ +G AVP LAKA+A+
Sbjct: 349 SVKEIARVQTFPDWFQFSQGTNSQTSINNRLDKQYKQIGNAVPVLLAKAVAS 400
>gb|AAB70829.1| (AF019752) HaeII methylase [Haemophilus influenzae biogroup
aegyptius]
Length = 318
Score = 116 bits (288), Expect = 3e-25
Identities = 100/321 (31%), Positives = 147/321 (45%), Gaps = 41/321 (12%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
K K +DLFAG GG LGF+ G + V + E K Y NF G K DI ISP
Sbjct: 2 KEYKTIDLFAGIGGIRLGFEAFGCKNVFSSEWDKYAQSMYEVNF-GEKPFG-DINDISPS 59
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
+I D D+++ G PC+PF+ K + D G L ++ KPK F++EN
Sbjct: 60 DIPDHDILLAGFPCQPFSIAG-------KGLGFADTRGTLFFNIEAILKAKKPKAFLLEN 112
Query: 126 VPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK-----P 175
V ++ + K + + +K GY +Y VLN LD+G PQ R R++I K P
Sbjct: 113 VKRLTTHDNGNTFKVINDKLNKLGYTVYHKVLNTLDFGLPQKRERIYIVGFLDKLHFEFP 172
Query: 176 KKIKGPRKVWDALKNIPIDAPNHDFWSPP------SKIARRIPRLR-WGEGAQRFGRFQN 228
K I ++ + L++ + PN+ F S S I + +P W E
Sbjct: 173 KPIGKYEELSNILESDDV-VPNNYFLSDELKRKRLSSITKDVPYPSIWHE------NISG 225
Query: 229 WIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSV---- 284
+ PY A +V G+ ++ R LT E RL GFPD F N+ + V
Sbjct: 226 NVSALPYSCALSVGGSYNYLVVNGVRRLTGPEMLRLQGFPDTFEI----NIPYSQVRKVA 281
Query: 285 GEAVPPPLAKAIANFIFDVLS 305
G +V P+ +AIA + + L+
Sbjct: 282 GNSVSVPVIRAIAGSMINSLN 302
>gb|AAF89681.1| (AF169965) cytosine-specific methyltransferase [Bacillus sp. LU11]
Length = 365
Score = 115 bits (286), Expect = 6e-25
Identities = 65/167 (38%), Positives = 93/167 (54%), Gaps = 17/167 (10%)
Query: 10 VLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIGD 69
V+ LF+G GG LGFK GF I+ AI+ K TY N G +I DI I +I +
Sbjct: 5 VVSLFSGGGGLDLGFKNSGFNIIWAIDIDKDAVLTYKENL-GDHIILGDITKIQEKDIPE 63
Query: 70 VDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQI 129
DV+IGGPPC+ F+ + RR + D G+LV +++R + ++PK FV ENV +
Sbjct: 64 ADVVIGGPPCQSFSLVGKRRSD--------DERGQLVWQYLRIINEIRPKCFVFENVVGL 115
Query: 130 MELE--------KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
+ L F + GY++ ++VLNA DYG PQ R+R+FI
Sbjct: 116 KSAKTAEGNLVLDELIIAFREIGYEVQWSVLNAADYGVPQRRKRIFI 162
>pir||S76359 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1001584|dbj|BAA10211.1| (D64000) cytosine-specific
methyltransferase [Synechocystis sp.]
Length = 424
Score = 115 bits (285), Expect = 7e-25
Identities = 72/184 (39%), Positives = 104/184 (56%), Gaps = 27/184 (14%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI--- 67
+DLFAG GG SLG + GF+I AA+E + HNFP I +DI ++S EI
Sbjct: 7 IDLFAGCGGMSLGLEAAGFDIAAAVEFDAVHCLVHHHNFPYGVTICRDIALVSAGEILRK 66
Query: 68 -------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV 120
D+D+I GGPPC+ F+ + R+ ++P++ L V E+VR + LKPK
Sbjct: 67 LNNKGYSSDIDLIAGGPPCQGFSLMGKRQLDDPRNSL--------VFEYVRMIRDLKPKY 118
Query: 121 FVMENVPQIM--ELEKYLR---KEFDKAGYDIY--FNVLNALDYGAPQVRRRVFI--SNL 171
F+ ENVP + + +K+L +EF+ GY I VL+A YGAPQ R+R+ I S
Sbjct: 119 FLFENVPGMRSGQHKKFLEELVREFETIGYHIEKPILVLDASLYGAPQKRKRLIILGSRK 178
Query: 172 ELKP 175
++KP
Sbjct: 179 DVKP 182
>sp|P24600|MTD1_HERAU MODIFICATION METHYLASE HGIDI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HGIDI) (M.HGIDI) >gi|94558|pir||S14029 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
HgiDIM - Herpetosiphon aurantiacus
>gi|43482|emb|CAA38938.1| (X55140) methyltransferase
[Herpetosiphon aurantiacus]
Length = 309
Score = 115 bits (285), Expect = 7e-25
Identities = 97/322 (30%), Positives = 156/322 (48%), Gaps = 43/322 (13%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNF--PGVKV-IAQDIKVISP 64
MK +DLFAG GG SLGF GFEIVAA++N++P TY NF P ++ +AQ +S
Sbjct: 1 MKTIDLFAGCGGMSLGFMQAGFEIVAAVDNWRPAINTYQQNFTHPIHELDLAQIDAAVSL 60
Query: 65 DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGR--LVLEFVRFVERLKPKVFV 122
+ ++IIGGPPC+ F++ R + +GR L L+F + V ++P +
Sbjct: 61 IKTHSPELIIGGPPCQDFSSAGKR----------DEGLGRANLTLDFAKIVLAIQPAWVI 110
Query: 123 MENV--PQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKG 180
MENV ++ ++ + GY + VL+A G PQ+R+R F+ + + I
Sbjct: 111 MENVERARLSKIHQQACSMLGDEGYSLAQVVLDASLCGVPQLRKRTFV--IGHRHGSIAD 168
Query: 181 PRKV-WDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKPAP 239
V L + ++ S + R PR ++ +P+P
Sbjct: 169 LANVLQQRLAKQSLTVRDYFGESLDTDYYYRHPR-----------TYERRAIFSVNEPSP 217
Query: 240 TVRGNSRFV------HPFE------DRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEA 287
T+RG +R + HP + RPLT +E++ + FP DF F+G ++ Q +G A
Sbjct: 218 TIRGVNRPIPATYRMHPKDAGDVSLARPLTTKERSLIQTFPLDFKFVGTKSEQEQMIGNA 277
Query: 288 VPPPLAKAIANFIFDVLSKERI 309
VP LA +A + L++ R+
Sbjct: 278 VPVNLAFFLATSLQAYLNQPRM 299
>sp|P31033|MTM4_NEIGO MODIFICATION METHYLASE NGOMIV (CYTOSINE-SPECIFIC METHYLTRANSFERASE
NGOMIV) (M.NGOMIV) >gi|281722|pir||A42709 DNA
modification methylase NgoMI - Neisseria gonorrhoeae
Length = 312
Score = 111 bits (276), Expect = 8e-24
Identities = 93/322 (28%), Positives = 139/322 (42%), Gaps = 41/322 (12%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIGDV 70
L++ AGAGG +LG + GF VA IE +T N P VI D+++ + +
Sbjct: 6 LEICAGAGGQALGLERAGFSHVALIEIEPSACQTLRLNRPDWNVIEGDVRLFQGEGYDGI 65
Query: 71 DVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV---- 126
D++ GG PC PF+ +L +D L E +R + PK ++ENV
Sbjct: 66 DLLAGGVPCPPFSKAG--------KQLGKDDERDLFPEAIRLAKETDPKAIMLENVRGLL 117
Query: 127 -PQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRV-FISNLELKPKKIKGPRKV 184
P+ ++ ++F K GY + +L A DYG Q+R RV F++ K P
Sbjct: 118 DPKFENYRNHITEQFAKLGYLGQWKLLYAADYGVSQLRPRVLFVALKNEYTNFFKWPEPN 177
Query: 185 WDALKNIP---IDAPNHDFWS------------PPSKIA--RRIPRLRWG-EGAQRFGRF 226
+ K + D + + W P+ +A + L W GR
Sbjct: 178 SEQPKTVGELLFDLMSENNWQGAHNWRLKAAQIAPTLVAVQKNTAVLTWDLHDPNAHGRS 237
Query: 227 QNWIRLHPYKPAPTVRGNSRFVHPFEDRP-LTVREQARLMGFPDDFVFLGGRNVQFDSVG 285
W+ V G R + F P LTVR AR+ GFPDD+ F G + + +G
Sbjct: 238 WVWM--------VQVCGIVRRLKTFTGMPRLTVRMTARIQGFPDDWQFFGKKTPMYRQIG 289
Query: 286 EAVPPPLAKAIANFIFDVLSKE 307
A PPP+A+A+ I L KE
Sbjct: 290 NAFPPPVAEAVGRQIIKALKKE 311
>emb|CAB44950.1| (AJ242840) DNA modification methylase [Neisseria gonorrhoeae]
>gi|5262959|emb|CAB45015.2| (AJ242839) DNA modification
methylase [Neisseria gonorrhoeae]
Length = 312
Score = 110 bits (273), Expect = 2e-23
Identities = 95/335 (28%), Positives = 141/335 (41%), Gaps = 67/335 (20%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIGDV 70
L++ AGAGG +LG + GF VA IE +T N P VI D+++ + +
Sbjct: 6 LEICAGAGGQALGLERAGFSHVALIEIEPSACQTLRLNRPDWNVIEGDVRLFQGEGYDGI 65
Query: 71 DVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV---- 126
D++ GG PC PF+ +L +D L E +R + PK ++ENV
Sbjct: 66 DLLAGGVPCPPFSKAG--------KQLGKDDERDLFPEAIRLAKETDPKAIMLENVRGLL 117
Query: 127 -PQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKGPRKVW 185
P+ ++ ++F K GY + +L A DYG Q+R PR ++
Sbjct: 118 DPKFENYRNHITEQFAKLGYLGQWKLLYAADYGVSQLR-----------------PRVLF 160
Query: 186 DALKNIPIDAPNHDFW-SPPSKIARRIPRLRWG-EGAQRFGRFQNWIRLHPYKPAPTVRG 243
ALKN + N W P S+ + + L + + NW RL + APT+ G
Sbjct: 161 VALKN---EYTNFFKWPEPNSEQPKTVGELLFDLMSENNWQGAHNW-RLKAAQIAPTLVG 216
Query: 244 NSRF------------------------------VHPFEDRP-LTVREQARLMGFPDDFV 272
S+ F P LTVR AR+ GFPDD+
Sbjct: 217 GSKKHGGADLGPTRSKRAWAELGVDGSGLWDSAPPEDFSGMPRLTVRMTARIQGFPDDWQ 276
Query: 273 FLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLSKE 307
F G + + +G A PPP+A+A+ I L KE
Sbjct: 277 FFGKKTPMYRQIGNAFPPPVAEAVGRQIIKALKKE 311
>gb|AAC00045.1| (U13922) putative type II 5-cytosoine methyltransferase
[Corynebacterium glutamicum]
Length = 363
Score = 109 bits (271), Expect = 3e-23
Identities = 93/321 (28%), Positives = 139/321 (42%), Gaps = 51/321 (15%)
Query: 10 VLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP---DE 66
++ F+G GG LG + VGF+ + A + + +TY HN G ++ DI I P D
Sbjct: 7 IVSTFSGCGGLDLGLQEVGFDPIWANDFSEEAVQTYKHNI-GDHIVHGDITEIDPFTDDT 65
Query: 67 IGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
I D D++ GG PC+ F+ I R + K G L F FV KPK F+ ENV
Sbjct: 66 IPDGDLVTGGFPCQDFSMIWKRPGLDGKR-------GTLYQNFRDFVAAKKPKAFIAENV 118
Query: 127 PQIMELEKYLR-------KEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK----- 174
++ ++ E + GY + + N +YG PQ R RV I +
Sbjct: 119 KGLLTANQHKAIKTIIEDLEAVEPGYIVKPRLYNFAEYGVPQFRERVLIVGIRRDTGFDF 178
Query: 175 --PKKIKGPR---------KVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRF 223
P GPR + +K++P + + ++ +RIP GE
Sbjct: 179 KHPAPTHGPRGDMPYKTAGQALKGVKDVPTNNNHMKIMPRTVEVLKRIPE---GENFTAI 235
Query: 224 GRFQNWI----------RLHPYKPAPTVR----GNSRFVHPFEDRPLTVREQARLMGFPD 269
+ + RLH +P+ T+ G + H E+R LT R++AR+ FPD
Sbjct: 236 PKDDPYYVKGMISHVYRRLHRDEPSKTLIAGGVGGTWGYHYEENRALTNRQRARIQSFPD 295
Query: 270 DFVFLGGRNVQFDSVGEAVPP 290
DF FLG +G AVPP
Sbjct: 296 DFEFLGSNTEVRRQIGNAVPP 316
>sp|P45000|MTD5_HAEIN PROBABLE MODIFICATION METHYLASE HINDV (CYTOSINE-SPECIFIC
METHYLTRANSFERASE HINDV) (M.HINDV)
>gi|1075022|pir||C64109 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
- Haemophilus influenzae (strain Rd KW20)
>gi|1574073|gb|AAC22700.1| (U32784) modification
methylase [Haemophilus influenzae Rd]
Length = 304
Score = 109 bits (269), Expect = 6e-23
Identities = 106/332 (31%), Positives = 147/332 (43%), Gaps = 75/332 (22%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFP---------GVKVIAQD 58
MK +DLF+G GG SLGF+L GFEI AA EN++ + Y +NF K +
Sbjct: 1 MKCVDLFSGCGGLSLGFELAGFEICAAFENWEKAIEIYKNNFSHPIYNIDLRNEKEAVEK 60
Query: 59 IKVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGR--LVLEFVRFVERL 116
IK SP D+I+GGPPC+ F++ R +GR L F V +
Sbjct: 61 IKKYSP------DLIMGGPPCQDFSSAGKRDIS----------LGRADLTYSFANIVCNI 104
Query: 117 KPKVFVMENVPQIME--LEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRV-FISNLE- 172
+PK FVMENV QI + + + + +F GY + +L+A G PQ R R I L
Sbjct: 105 RPKWFVMENVEQIKKSHILQDIINQFIDFGYGLTSAILDASYCGVPQSRTRFSLIGKLNS 164
Query: 173 --------LKPKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFG 224
L K P V D L N + N +F+ R PR R G
Sbjct: 165 EHNFLIPTLSRKLSDKPMTVRDYLGN----SLNLEFY-------YRHPR-----NYNRRG 208
Query: 225 RFQNWIRLHPYKPAPTVRGNSR--------------FVHPFEDRPLTVREQARLMGFPDD 270
F +P+PT+RG +R V + RPLT E++ + FP
Sbjct: 209 IFS------IDEPSPTIRGVNRPIPKGYNINSCDPKGVELAKVRPLTTIERSYIQTFPKS 262
Query: 271 FVFLGGRNVQFDSVGEAVPPPLAKAIANFIFD 302
F+F G + +G AVP LAK +A+ I +
Sbjct: 263 FLFSGTKTDLEQMIGNAVPVNLAKFVASAIIN 294
>pir||S47248 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) phi3TII - phage phi-3T
>gi|535137|emb|CAA56493.1| (X80202) type II
DNA-methyltransferase [Bacteriophage phi-3T]
Length = 326
Score = 108 bits (266), Expect = 1e-22
Identities = 99/318 (31%), Positives = 143/318 (44%), Gaps = 33/318 (10%)
Query: 10 VLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIGD 69
VL+LF G G + GFK G+EIV A++ K K Y HNF G V DI I D + D
Sbjct: 16 VLELFCGGGLGATGFKSAGYEIVKALDIDKNAVKAYRHNF-GDYVEQADINEIDIDSLPD 74
Query: 70 VDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQI 129
DVI GGPPC+ F+ + + G+LV ++ +ER +PK FV ENV +
Sbjct: 75 TDVIFGGPPCQDFSVAGKGVGADGER-------GKLVWRYLEIIERKQPKAFVFENVKGL 127
Query: 130 MELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI----SNLELK---PKK 177
+ L ++F++ GY+I + V+NA DYG Q R RVFI ++L K P
Sbjct: 128 ITKRHRPTFDALIEKFNEIGYEISWEVVNAWDYGVAQKRERVFIVGVRNDLGFKFDFPNP 187
Query: 178 IKG---PRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWG-EGAQRFGRFQNWIRLH 233
++G R + D + ++P F+ + + + +G E + QN L
Sbjct: 188 LEGDYQTRVLRDVIGDLP--EVGEYFYVNRGGWGKCLVKSVFGLEDVSPTIKSQN-ANLP 244
Query: 234 PYKPAPTVRG----NSRFVHPFEDRPLTVREQARLMGFPDDFVFLG--GRNVQFDSVGEA 287
P P N P R TVRE R+ PD +V Q+ VG
Sbjct: 245 PGYPGHPKDADQICNRPISQPKAPRRFTVRECLRIQSAPDTYVLPDDISLTAQYRIVGNG 304
Query: 288 VPPPLAKAIANFIFDVLS 305
+ +A I + D LS
Sbjct: 305 IASRVAWYIGRAVADQLS 322
>gb|AAG31558.1| (AF290880) SgrAIM methylase [Streptomyces griseus]
Length = 429
Score = 108 bits (266), Expect = 1e-22
Identities = 63/178 (35%), Positives = 100/178 (55%), Gaps = 29/178 (16%)
Query: 9 KVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI--------- 59
K + LF+G GGF G +L GF + AA+E + A TY HNFP V + D+
Sbjct: 25 KAVSLFSGCGGFCEGVRLAGFSVEAAVELDRFAAVTYRHNFPEVPLFEGDVHDFLNDSSE 84
Query: 60 ------KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFV 113
+ S + G++D++ GGPPC+ ++ I R ++P+++LY E+VR +
Sbjct: 85 TWRGEAERFSDVKAGNIDLLFGGPPCQGYSQIGTRILDDPRNQLY--------AEYVRVL 136
Query: 114 ERLKPKVFVMENVPQIMELEKYLRKE-----FDKAGY-DIYFNVLNALDYGAPQVRRR 165
+ L+P+VF+MENVP ++ ++K K F +AGY + V+ A D+G PQ+RRR
Sbjct: 137 KTLRPRVFLMENVPNMLLMDKGRFKREVLAAFAEAGYSNCGVTVVAASDHGVPQLRRR 194
>gb|AAB03206.2| (U42459) cytosine DNA methylase M.NgoI [Neisseria gonorrhoeae]
Length = 317
Score = 107 bits (264), Expect = 2e-22
Identities = 95/325 (29%), Positives = 145/325 (44%), Gaps = 46/325 (14%)
Query: 9 KVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIG 68
K +DLF+G GG LGF+ G V + E K + Y NF G K DI I P +I
Sbjct: 3 KTIDLFSGIGGIRLGFEKYGCTNVFSSEWDKYARQVYEANF-GEKPFG-DINGIDPSDIP 60
Query: 69 DVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQ 128
D D+++ G PC+PF+ K + D G L ++ +PK F++ENV +
Sbjct: 61 DHDILLAGFPCQPFSIAG-------KGLGFEDTRGTLFFNIAEILKTKQPKAFLLENVKR 113
Query: 129 IMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLE-----LKPKKI 178
+ + + + + + GY +YF VLN LD+G PQ R R++I P+ I
Sbjct: 114 LTTHDSGRTFRIVLETLKQLGYTVYFKVLNTLDFGLPQKRERIYIVGFSDNIPFYFPEPI 173
Query: 179 KGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLR--------WGEGAQRFGRFQNWI 230
R + + L+N P++ F S K +R+ L+ W E +
Sbjct: 174 NQYRPLGELLENDRDVEPSY-FLSDTLK-QKRLAALKKAPPTPSIWHE------NIGGNV 225
Query: 231 RLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSV----GE 286
PY A G+ ++ R LT RE RL GFPDDF N+ + V G
Sbjct: 226 SALPYSCALRAGGSYNYLVVNGVRRLTGREMLRLQGFPDDFEI----NIPYSQVRKVAGN 281
Query: 287 AVPPPLAKA---IANFIFDVLSKER 308
+V P+ +A I + +F S ++
Sbjct: 282 SVSVPVIEATRKICSLLFPARSNKK 306
>sp|P34882|MTAA_SYNP2 MODIFICATION METHYLASE AQUI ALPHA SUBUNIT (CYTOSINE-SPECIFIC
METHYLTRANSFERASE AQUI ALPHA SUBUNIT) (M.AQUI ALPHA
SUBUNIT) >gi|2126509|pir||I39659 modification methylase
AquI, alpha protein - Synechococcus sp. (PCC 7002)
>gi|142180|gb|AAA22067.1| (M28051) M.AquI alpha protein
[Synechococcus PCC7002]
Length = 248
Score = 106 bits (262), Expect = 4e-22
Identities = 79/249 (31%), Positives = 110/249 (43%), Gaps = 63/249 (25%)
Query: 9 KVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI- 67
K++ LF+GAGG +GF GF A+E T N P VI DI I+ I
Sbjct: 4 KLISLFSGAGGMDIGFHAAGFSTAVAVEQDPSCCNTLRLNMPDTPVIEGDITSITTQVIL 63
Query: 68 -------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV 120
++D++IGGPPC+ F+ R + DP G LVLEF+R V PK
Sbjct: 64 EAAKVNPLEIDLVIGGPPCQSFSLAGKRMGMD-------DPRGMLVLEFLRVVREALPKC 116
Query: 121 FVMENVPQIMELE----------------KYLRKEFDKAGYDIYFNVLNALDYGAPQVRR 164
FVMENV ++ KY KE+ Y + ++VLNA D+G PQ R
Sbjct: 117 FVMENVKGMINWSKGKALEAIMTEASQPIKYAGKEYK---YAVSYHVLNAADFGVPQFRE 173
Query: 165 RVFI----------------------SNLELKPKKIKGPRKVWDALKNIPIDAPNHDFWS 202
RVFI ++L K++K + V DA+ +P +
Sbjct: 174 RVFIVGNRLGKTFQFPEPTHGPSNQARQIDLFGKQLKPYKTVQDAISTLPPA-------T 226
Query: 203 PPSKIARRI 211
PPS +A R+
Sbjct: 227 PPSAMALRV 235
>sp|P25262|MTB1_HERAU MODIFICATION METHYLASE HGIBI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HGIBI) (M.HGIBI) >gi|94552|pir||S22307 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
HgiBI - Herpetosiphon aurantiacus
>gi|43478|emb|CAA38927.1| (X55137) methyltransferase
[Herpetosiphon aurantiacus]
Length = 437
Score = 104 bits (257), Expect = 1e-21
Identities = 81/274 (29%), Positives = 133/274 (47%), Gaps = 37/274 (13%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFP--GVKVIAQDIKVIS 63
++ + +DLFAG GGF LG + VG VA+ E + K Y N+P GV DI I
Sbjct: 2 QQFRFIDLFAGIGGFRLGLEAVGGVCVASAEIDQQAIKVYRQNWPTDGVDHNLGDITAI- 60
Query: 64 PDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
++ DV++GG PC+P++ K++ + DP G+L + +R V+ +PK F+
Sbjct: 61 -QQLPAHDVLVGGVPCQPWSIAG-------KNQAFDDPRGQLWADVIRLVQINQPKAFIF 112
Query: 124 ENVPQIMELEKYLRKE-----FDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK---- 174
ENV +++ L E F GY +++ +LN+ D+G Q R RVFI ++ K
Sbjct: 113 ENVKGLVDPRNRLCLEIILDSFKDLGYSVFYKLLNSFDFGVAQNRDRVFIVGIQQKLDLN 172
Query: 175 ----PKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRF---GRFQ 227
P+ + ++++ L N ++ P S P I R + R G + G F
Sbjct: 173 GFSFPEYTESEQRLYHILDN--LEVPETKLESIP--IQRNLFGERIDVGYNKLTPRGAFN 228
Query: 228 NWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQ 261
++ L+ + PT +H +E P T RE+
Sbjct: 229 DFFILNDIRNGPT------SIHSWEIYPTTEREK 256
>sp|P25266|MTE1_HERAU MODIFICATION METHYLASE HGIEI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HGIEI) (M.HGIEI) >gi|43471|emb|CAA38944.1| (X55142)
methyltransferase [Herpetosiphon aurantiacus]
Length = 437
Score = 104 bits (256), Expect = 2e-21
Identities = 82/274 (29%), Positives = 134/274 (47%), Gaps = 37/274 (13%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFP--GVKVIAQDIKVIS 63
++ + +DLFAG GGF LG + VG VA+ E + K Y N+P GV DI I
Sbjct: 2 QQFRFIDLFAGIGGFRLGLEAVGGVCVASAEIDQQAIKVYWQNWPTDGVDHNLGDITQI- 60
Query: 64 PDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
++ DV++GG PC+P++ K++ + DP G+L + +R V+ +PK F+
Sbjct: 61 -QQLPAHDVLVGGVPCQPWSIAG-------KNQAFDDPRGQLWADVIRLVQINQPKAFIF 112
Query: 124 ENVPQIMELEKYLRKE-----FDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK---- 174
ENV +++ L E F GY +++ +LN+ D+G Q R RVFI ++ K
Sbjct: 113 ENVKGLVDPRNRLCLEIILDSFKDLGYSVFYKLLNSFDFGVAQNRDRVFIVGIQQKLDLN 172
Query: 175 ----PKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRF---GRFQ 227
P+ + ++++ L N ++AP S P I R + R G + G F
Sbjct: 173 GFSFPEYAESDQRLYHILDN--LEAPETKLESIP--IQRNLFGERIEVGYNKLTPRGAFN 228
Query: 228 NWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQ 261
++ L+ + PT +H +E P T RE+
Sbjct: 229 DFFILNDIRNGPT------SIHSWEIYPTTEREK 256
>sp|P34879|MTS2_SHISO MODIFICATION METHYLASE SSOII (CYTOSINE-SPECIFIC METHYLTRANSFERASE
SSOII) (M.SSOII) >gi|419589|pir||JT0744 site-specific
DNA-methyltransferase (EC 2.1.1.-) - Shigella sonnei
plasmid P4 >gi|294244|gb|AAA98279.1| (M86545)
C5-cytosine methylase [Plasmid P4]
>gi|11559818|gb|AAG38101.1|AF300473_2 (AF300473)
DNA-methyltransferase MKpn2kI [Klebsiella pneumoniae]
Length = 379
Score = 104 bits (256), Expect = 2e-21
Identities = 89/324 (27%), Positives = 141/324 (43%), Gaps = 39/324 (12%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVG-FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVIS 63
N R +++DLFAG GG LGF +V + E K KTY N+ DI I
Sbjct: 69 NGRYRMIDLFAGIGGTRLGFHQTNAVNVVFSSEWDKFAQKTYHANYGDFP--DGDITKID 126
Query: 64 PDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
+I D ++++GG PC F+ ++ N D G L + R ++ KP F++
Sbjct: 127 EKDIPDHEILVGGFPCVAFSQAGLKKGFN-------DTRGTLFFDIARIIKEKKPHAFLL 179
Query: 124 ENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK---- 174
ENV ++ +K ++ ++ Y +Y+N+ A D+G PQ R R++I +
Sbjct: 180 ENVKNLLGHDKGRTFSIIKNTLEELNYTVYYNIFAAKDFGVPQNRERIYIVGFNKEKVRN 239
Query: 175 ------PKKIKGPRKVWDAL-KNIPIDAPNHD-FWSPPSKIARRIPRLRWGEGAQRFGRF 226
P +K +V D L K++ D W+ + R++ G+G +G F
Sbjct: 240 HEHFTFPTPLKTKTRVGDILEKSVDNKYTLSDALWNGHQR--RKLVNAAAGKGFG-YGLF 296
Query: 227 Q------NWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQ 280
N I YK + + +P R +T RE +RL GFP DF+
Sbjct: 297 NENSPYTNTISARYYKDGSEILIEQKGSNP---RKITPREASRLQGFPSDFIIPVSDTQA 353
Query: 281 FDSVGEAVPPPLAKAIANFIFDVL 304
+ G +V P+ AIA I L
Sbjct: 354 YKQFGNSVAVPVINAIAEKIISTL 377
>pir||JC4656 rRNA endonuclease (EC 3.1.27.10) AgeI - "Agrobacterium
gelatinovorum >gi|1695647|dbj|BAA11333.1| (D78259) ageI
metylase [Agrobacterium gelatinovorum]
>gi|8037880|gb|AAF71525.1|AF247972_2 (AF247972) AgeI
methylase [Ruegeria gelatinovora]
>gi|1588637|prf||2209243A AgeI methylase [Ruegeria
gelatinovora]
Length = 429
Score = 104 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 88/174 (49%), Gaps = 21/174 (12%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
MK +DLF GAGG GF+ GF + A ++ P TY N P I+ + P +I
Sbjct: 1 MKTIDLFCGAGGLGEGFRQAGFSALYANDHETPALATYKENHPDAVCSTDSIETVDPKKI 60
Query: 68 --------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
G VDV++GGPPC+ F+ RR ++ +++LY + + FVE +PK
Sbjct: 61 REDLGVAPGQVDVVMGGPPCQGFSTYGQRRDDDARNQLY--------VPYFGFVEEFRPK 112
Query: 120 VFVMENVPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
F++ENV ++ + + + GY L+A +YG PQ RRRVFI
Sbjct: 113 AFLIENVVGLLSMSGGAVLADMVARAEALGYAADVVTLDACEYGVPQHRRRVFI 166
>gb|AAC45971.1| (U65460) DNA cytosine methyltransferase M.SenPI [Salmonella
enteritidis]
Length = 379
Score = 104 bits (256), Expect = 2e-21
Identities = 89/324 (27%), Positives = 141/324 (43%), Gaps = 39/324 (12%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVG-FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVIS 63
N R +++DLFAG GG LGF +V + E K KTY N+ DI I
Sbjct: 69 NGRYRMIDLFAGIGGTRLGFHQTNAVNVVFSSEWDKFAQKTYHANYGDFP--DGDITKID 126
Query: 64 PDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
+I D ++++GG PC F+ ++ N D G L + R ++ KP F++
Sbjct: 127 EKDIPDHEILVGGFPCVAFSQAGLKKGFN-------DTRGTLFFDIARIIKEKKPHAFLL 179
Query: 124 ENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK---- 174
ENV ++ +K ++ ++ Y +Y+N+ A D+G PQ R R++I +
Sbjct: 180 ENVKNLLGHDKGRTFSIIKNTLEELNYTVYYNIFAAKDFGVPQNRERIYIVGFNKEKVRN 239
Query: 175 ------PKKIKGPRKVWDAL-KNIPIDAPNHD-FWSPPSKIARRIPRLRWGEGAQRFGRF 226
P +K +V D L K++ D W+ + R++ G+G +G F
Sbjct: 240 HEHFTFPTPLKTKTRVGDILEKSVDNKYTLSDALWNGHQR--RKLVNAAAGKGFG-YGLF 296
Query: 227 Q------NWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQ 280
N I YK + + +P R +T RE +RL GFP DF+
Sbjct: 297 NENSPYTNTISARYYKDGSEILIEQKGSNP---RKITPREASRLQGFPSDFIIPVSDTQA 353
Query: 281 FDSVGEAVPPPLAKAIANFIFDVL 304
+ G +V P+ AIA I L
Sbjct: 354 YKQFGNSVAVPVINAIAEKIISTL 377
>pir||JC5542 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - Salmonella
typhi >gi|1871451|dbj|BAA11167.1| (D73442) C5-cytosine
methylase [Salmonella typhi] >gi|3421011|emb|CAA76526.1|
(Y16897) M.Ecl18kI (DNA-methyltransferase) [Enterobacter
cloacae]
Length = 379
Score = 104 bits (256), Expect = 2e-21
Identities = 89/324 (27%), Positives = 141/324 (43%), Gaps = 39/324 (12%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVG-FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVIS 63
N R +++DLFAG GG LGF +V + E K KTY N+ DI I
Sbjct: 69 NGRYRMIDLFAGIGGTRLGFHQTNAVNVVFSSEWDKFAQKTYHANYGDFP--DGDITKID 126
Query: 64 PDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
+I D ++++GG PC F+ ++ N D G L + R ++ KP F++
Sbjct: 127 EKDIPDHEILVGGFPCVAFSQAGLKKGFN-------DTRGTLFFDIARIIKEKKPHAFLL 179
Query: 124 ENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK---- 174
ENV ++ +K ++ ++ Y +Y+N+ A D+G PQ R R++I +
Sbjct: 180 ENVKNLLGHDKGRTFSIIKNTLEELNYTVYYNIFAAKDFGVPQNRERIYIVGFNKEKVRN 239
Query: 175 ------PKKIKGPRKVWDAL-KNIPIDAPNHD-FWSPPSKIARRIPRLRWGEGAQRFGRF 226
P +K +V D L K++ D W+ + R++ G+G +G F
Sbjct: 240 HEHFTFPTPLKTKTRVGDILEKSVDNKYTLSDALWNGHQR--RKLVNAAAGKGFG-YGLF 296
Query: 227 Q------NWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQ 280
N I YK + + +P R +T RE +RL GFP DF+
Sbjct: 297 NENSPYTNTISARYYKDGSEILIEQKGSNP---RKITPREASRLQGFPSDFIIPVSDTQA 353
Query: 281 FDSVGEAVPPPLAKAIANFIFDVL 304
+ G +V P+ AIA I L
Sbjct: 354 YKQFGNSVAVPVINAIAEKIISTL 377
>sp|P50196|MTE8_ECOLI MODIFICATION METHYLASE ECO47II (CYTOSINE-SPECIFIC METHYLTRANSFERASE
ECO47II) (M.ECO47II) >gi|558571|emb|CAA57629.1| (X82105)
site-specific DNA-methyltransferase (cytosine-specific)
[Escherichia coli] >gi|1098127|prf||2115269B
methyltransferase Eco47IIM [Escherichia coli]
Length = 417
Score = 102 bits (253), Expect = 4e-21
Identities = 94/346 (27%), Positives = 139/346 (40%), Gaps = 54/346 (15%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVIS- 63
N VL+LFAGAGG +LG + G + V E KT N P V+ D+ +
Sbjct: 78 NNVYTVLELFAGAGGMALGLEKAGLKSVLLNEIDSHACKTLRKNRPEWNVVEGDVSQVDF 137
Query: 64 PDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVM 123
VDV+ GG PC+ F+ K + D G L EF R + + PKV +
Sbjct: 138 TPYRNTVDVLAGGFPCQAFSYAG-------KKLGFEDTRGTLFFEFARAAKEINPKVLLA 190
Query: 124 ENVPQIMELE-----KYLRKEFDKAGYDIYF-NVLNALDYGAPQVRRRVFI--------- 168
ENV ++ + + ++ GY ++ VL A+ Y PQ R R+ I
Sbjct: 191 ENVRGLLNHDAGRTLETIKNIITDLGYTLFEPRVLKAIFYKVPQKRERLIIVAVRNDLAD 250
Query: 169 -----------SNLELKPKKIKG---------------PRKVWDALKNIPIDAPNHDFWS 202
L LK KG P++ + L +P P +
Sbjct: 251 GIDYEWPSSYNKILTLKDALKKGELYDSDVPESEGQKYPKRKAEILSMVP---PGGYWRD 307
Query: 203 PPSKIARR--IPRLRWGEGAQRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVRE 260
P I + + G G R +W + + HP E RPLTVRE
Sbjct: 308 LPEDIQKEYMLKSFYLGGGKTGMARRLSWDEPSLTLTCAPAQKQTERCHPEETRPLTVRE 367
Query: 261 QARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLSK 306
AR+ FPD++VF G + ++ +G AVP L+ A+ + +L K
Sbjct: 368 YARIQTFPDEWVFEGPMSAKYKQIGNAVPVNLSFAVGKSVVHLLDK 413
>sp|P13906|MTB1_BACSH MODIFICATION METHYLASE BSPRI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
BSPRI) (M.BSPRI) >gi|1084213|pir||S48066 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
BspRI - Bacillus sphaericus >gi|7427889|pir||S07792
site-specific DNA-methyltransferase (cytosine-specific)
(EC 2.1.1.73) BspR - Bacillus sphaericus
>gi|632681|gb|AAB31678.1| DNA
(cytosine-5)-methyltransferase, m5C-MTase {BspRI
restriction-modification system} [Escherichia coli,
Peptide, 424 aa]
Length = 424
Score = 102 bits (253), Expect = 4e-21
Identities = 91/355 (25%), Positives = 153/355 (42%), Gaps = 71/355 (20%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVG----------------------------FEIVAAIENF 38
+ VL LF GAGG LGF+L G F V A + F
Sbjct: 57 KFNVLSLFCGAGGLDLGFELAGLEQSLGTDKALEAFKDRDVYNAIRHESVFHTVYANDIF 116
Query: 39 KPKAKTYSHNFPG-VKVIAQDIKVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRL 97
+TY N P V + +DI+ I E +++IGG PC F+ PR ++ ++ L
Sbjct: 117 SEALQTYEKNMPNHVFIHEKDIRKIK--EFPSANLVIGGFPCPGFSEAGPRLVDDERNFL 174
Query: 98 YRDPIGRLVLEFVRFVERLKPKVFVMENVPQIM-----ELEKYLRKEFDKAGYDIYFNVL 152
Y + F+R + +++P++FV ENV +M E+ + + ++F AGY + +L
Sbjct: 175 Y--------IHFIRCLMQVQPEIFVAENVKGMMTLGGGEVFRQIVEDFGAAGYRVEARLL 226
Query: 153 NALDYGAPQVRRRVFISNLEL--------------KPKKIKGPRKVWDALKNIPIDAPNH 198
NA DYG PQ+R RV I + + +K + +A+ ++ +D +
Sbjct: 227 NARDYGVPQIRERVIIVGVRNDIDFNYEYPEITHGNEEGLKPYVTLEEAIGDLSLDPGPY 286
Query: 199 DFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFED---RP 255
S + R + +W + + +HP ++++ P + R
Sbjct: 287 FTGSYSTIFMSRNRKKKWTDQSFTIQASGRQAPIHPGGLPMEKVDKNKWIFPDGEENHRR 346
Query: 256 LTVREQARLMGFPDDFVFLGGRNV----------QFDSVGEAVPPPLAKAIANFI 300
L+V+E R+ FPD + F G N+ Q+ +G AVP L +A+A I
Sbjct: 347 LSVKEIKRIQTFPDWYEFSDGGNMKVSVNNRLDKQYKQIGNAVPVFLTRAVAKSI 401
>sp|P34877|MTSA_LACLC MODIFICATION METHYLASE SCRFIA (CYTOSINE-SPECIFIC METHYLTRANSFERASE
SCRFIA) (M.SCRFIA) (M.SCRFI-A) >gi|477398|pir||A48966
methylase - Lactococcus lactis >gi|149493|gb|AAA25220.1|
(M87289) SCRFI methylase [Lactococcus lactis]
>gi|2327034|gb|AAB66696.1| (U89998) 5-methyl-cytosine
methyltransferase [Lactococcus lactis subsp. cremoris]
Length = 389
Score = 102 bits (251), Expect = 7e-21
Identities = 85/323 (26%), Positives = 141/323 (43%), Gaps = 33/323 (10%)
Query: 7 RMKVLDLFAGAGGFSLGF-KLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
+ K++DLFAG GG LGF + + V + E K KTY NF DI I
Sbjct: 78 KYKMIDLFAGIGGTRLGFHQTEKVKSVFSSEIDKFAIKTYKANFGDEP--HGDITKIDEK 135
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
+I D D+++GG PC+ F+ K + D G L E R ++ +PK F++EN
Sbjct: 136 DIPDHDILVGGFPCQAFSQAG-------KKLGFDDTRGTLFFEIARIIKEKRPKAFLLEN 188
Query: 126 VPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK------ 174
V + +K + ++ Y+++ + A D+G PQ R R++I + K
Sbjct: 189 VKNLKTHDKGRTFKTILNTLEELDYEVHTALFKARDFGLPQNRERIYIVGFDRKSISNYS 248
Query: 175 ----PKKIKGPRKVWDALKNIPID--APNHDFWSPPSKIARRIPRLRWGEGAQRFGR--- 225
P ++ +V + L+++ D + W + + G G F +
Sbjct: 249 DFQMPTPLQEKTRVGNILESVVDDKYTISDKLWDGHQRRKTENKKNGKGFGYTLFNQDSE 308
Query: 226 FQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVG 285
+ N + YK + + +P R +T RE ARL GFP++F+ + G
Sbjct: 309 YTNTLSARYYKDGSEILIEQKNKNP---RKITPREAARLQGFPENFIIPVSDTQAYKEFG 365
Query: 286 EAVPPPLAKAIANFIFDVLSKER 308
+V P AIA + +VL K +
Sbjct: 366 NSVAVPTIHAIAEKMLEVLEKSK 388
>sp|P25264|MTC2_HERAU MODIFICATION METHYLASE HGICII (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HGICII) (M.HGICII) >gi|43464|emb|CAA38935.1| (X55139)
methyltransferase [Herpetosiphon aurantiacus]
Length = 437
Score = 101 bits (249), Expect = 1e-20
Identities = 78/278 (28%), Positives = 131/278 (47%), Gaps = 45/278 (16%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
K+ + +DLFAG GGF LG + VG V + E + K Y N+P + + +
Sbjct: 2 KQFRFIDLFAGIGGFRLGLEAVGGICVGSAEIDQQAIKVYRQNWPTDRSEHNLGDITTLQ 61
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
++ D+++GG PC+P++ K++ + DP G+L + +R V +PK F+ EN
Sbjct: 62 QLPAHDLVVGGVPCQPWSIAG-------KNQAFDDPRGQLWADVIRLVRINQPKAFIFEN 114
Query: 126 VPQIMELEKYLRKE-----FDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK------ 174
V +++ L E F GY++Y+ +LN+ DYG Q R RVFI ++ K
Sbjct: 115 VKGLIDPRNRLCLESILDSFKAEGYNVYYKLLNSFDYGVAQNRDRVFIIGIQQKLGVPDF 174
Query: 175 --PKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIP--RLRWGE----GAQRF--- 223
P+ + ++++D L N+ PS I +P R +GE G +
Sbjct: 175 SFPEYSESEQRLYDILDNL----------QTPSIIPESLPIQRNLFGERIEVGFNKLTPR 224
Query: 224 GRFQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQ 261
G F ++ L+ + PT +H +E T RE+
Sbjct: 225 GAFNDFFILNDIRNGPT------SIHSWEIYATTEREK 256
>pir||JC1165 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) HgiCII - Herpetosiphon aurantiacus
Length = 437
Score = 101 bits (249), Expect = 1e-20
Identities = 78/278 (28%), Positives = 131/278 (47%), Gaps = 45/278 (16%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
K+ + +DLFAG GGF LG + VG V + E + K Y N+P + + +
Sbjct: 2 KQFRFIDLFAGIGGFRLGLEAVGGICVGSAEIDQQAIKVYRQNWPTDRSEHNLGDITTLQ 61
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
++ D+++GG PC+P++ K++ + DP G+L + +R V +PK F+ EN
Sbjct: 62 QLPAHDLVVGGVPCQPWSIAG-------KNQAFDDPRGQLWADVIRLVRINQPKAFIFEN 114
Query: 126 VPQIMELEKYLRKE-----FDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK------ 174
V +++ L E F GY++Y+ +LN+ DYG Q R RVFI ++ K
Sbjct: 115 VKGLIDPRNRLCLESILDSFKAEGYNVYYKLLNSFDYGVAQNRDRVFIIGIQQKLGVPDF 174
Query: 175 --PKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIP--RLRWGE----GAQRF--- 223
P+ + ++++D L N+ PS I +P R +GE G +
Sbjct: 175 SFPEYSESEQRLYDILDNL----------QTPSIIPESLPIQRNLFGERIEVGFNKLTPR 224
Query: 224 GRFQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQ 261
G F ++ L+ + PT +H +E T RE+
Sbjct: 225 GAFNDFFILNDIRNGPT------SIHSWEIYATTEREK 256
>gb|AAC97118.1| (AF027867) SacI methylase [Streptomyces achromogenes]
Length = 390
Score = 101 bits (248), Expect = 2e-20
Identities = 98/372 (26%), Positives = 154/372 (41%), Gaps = 77/372 (20%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVG------------FEIVAAIENFKPKAKTYSHNFPGV 52
N + V+ LF+GAGG + + A + + T S NFP
Sbjct: 2 NHELPVISLFSGAGGLDCAIESCAEPPLVQDGSGSPLRVAVATDYEQTALDTLSANFPHT 61
Query: 53 KVIAQDIKVISPDEI--------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGR 104
K + DI+ I E+ GD ++IGGPPC PF+ +E R DP
Sbjct: 62 KTLCGDIQTIPTAELLEAGGLKPGDPTLVIGGPPCTPFSKSGFWIEEK---RNSADPNAS 118
Query: 105 LVLEFVRFVERLKPKVFVMENVPQIMELEKYLRKEFDK-------AGYDIYFNVLNALDY 157
L+ E+VR V KP+ F++ENV + K + +FD+ AGY+ F VL A +Y
Sbjct: 119 LLDEYVRVVRESKPEAFILENVQGLTY--KTHQAQFDRLIAGLKDAGYNPTFRVLLAAEY 176
Query: 158 GAPQVRRRVFI---------------SNLELKPKKIKGPRKV-----WDALKNIP-IDAP 196
G PQ+RRRVF+ + E + ++ K+ +AL +P +
Sbjct: 177 GVPQLRRRVFVVGRRDGKAFHFPETTHSGESERDRVIDHTKIPFTSLREALAGLPDVPEA 236
Query: 197 NHDFWSPPSKIARRIP--------RLRWGEGAQRFGRFQNW---IRLHPYKPAPTVRGN- 244
+++A +P R+G + R + W ++ P +P+ T++
Sbjct: 237 GEVVEGTYAELAAEVPPGQNYLWHTDRYGGRNEFKWRSRYWTFLLKADPDRPSTTLQAQP 296
Query: 245 SRFVHPF------------EDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPL 292
+V PF R V E R+M FPD+FVF G + +G VP L
Sbjct: 297 GPWVGPFHWENVKNANGEERARRFRVAEMKRIMTFPDEFVFTGVKREVQRQIGNPVPVEL 356
Query: 293 AKAIANFIFDVL 304
K + + + L
Sbjct: 357 GKVVVRALMEQL 368
>gb|AAC37047.1| (L09189) orf; homologous to Haemophilus parahaemolyticus hphIM(C)
Accession Number M24625 [Neisseria meningitidis]
Length = 276
Score = 100 bits (247), Expect = 2e-20
Identities = 57/170 (33%), Positives = 97/170 (56%), Gaps = 22/170 (12%)
Query: 11 LDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIGD- 69
+DLF+GAGG SLGF+ GF+ + ++E +TY NFP +++ +D+ ++ ++ +
Sbjct: 8 IDLFSGAGGLSLGFEQAGFQQLLSVEMESDYCQTYRTNFPHHQLLQKDLTTLTEQDLINC 67
Query: 70 -----VDVIIGGPPCEPFT---AINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVF 121
VD+IIGGPPC+ F+ I ++P++ L++ EFVR V+ ++P F
Sbjct: 68 LNGQAVDLIIGGPPCQGFSMAGKIGRTFTDDPRNHLFK--------EFVRIVKIVQPYFF 119
Query: 122 VMENVPQIM-----ELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRV 166
VMENV ++ + + + F GY + +L+A D+G PQ+R RV
Sbjct: 120 VMENVARLYTHNSGKTRIEIIQAFQNIGYSVECKILSAADFGVPQIRSRV 169
>emb|CAA73243.1| (Y12707) methylase [Lactococcus lactis subsp. cremoris]
Length = 317
Score = 100 bits (246), Expect = 3e-20
Identities = 88/322 (27%), Positives = 138/322 (42%), Gaps = 33/322 (10%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
+K+ FAG GG LGF+ GF+ + A E A T+ NF VKV +DI + DEI
Sbjct: 2 LKIASFFAGVGGIDLGFENAGFKTIYANEFDNYAADTFEMNF-DVKVDRRDINDVQADEI 60
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
D D+++ G PC+ F+ R+ N + G L E VR +E KP+V ENV
Sbjct: 61 PDFDIMLAGFPCQAFSIAGYRQGFNDEQGR-----GNLFFELVRILETKKPRVAFFENVK 115
Query: 128 QIMELE-----KYLRKEFDKAGYDIYFNVLNALDYG-APQVRRRVFI---------SNLE 172
++ + + + E ++ GY F V NA +YG PQ R R++I +N E
Sbjct: 116 NLVSHDSGNTFRVICSELERLGYKYLFQVFNASEYGNIPQNRERIYIVAFKNKKDYANFE 175
Query: 173 LKPKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRL 232
L PK I + D + + S +K + R + ++R
Sbjct: 176 L-PKSIPLKTTIHDVIDFSKKQDDKFYYTSEKNKFFDELKENMTNHDTTYQWR-RVYVRE 233
Query: 233 HPYKPAPTVRGNSR---------FVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQ-FD 282
+ PT+ N + + R LT RE + GFP ++ N + +
Sbjct: 234 NKSNLVPTLTANMGTGGHNVPIILTYSGDIRKLTPRECFNVQGFPKEYKLPNQSNGRLYK 293
Query: 283 SVGEAVPPPLAKAIANFIFDVL 304
G +V P+ + IA + D +
Sbjct: 294 QAGNSVVVPVIERIAKNLADTI 315
>emb|CAA33764.1| (X15758) methylase [Bacillus sphaericus]
Length = 424
Score = 99.8 bits (245), Expect = 4e-20
Identities = 98/357 (27%), Positives = 155/357 (42%), Gaps = 75/357 (21%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVG----------------------------FEIVAAIENF 38
+ VL LF GAGG LGF+L G F V A + F
Sbjct: 57 KFNVLSLFCGAGGLDLGFELAGLEQSLGTDKALEAFKDRDVYNAIRHESVFHTVYANDIF 116
Query: 39 KPKAKTYSHNFPG-VKVIAQDIKVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRL 97
+TY N P V + +DI+ I E +++IGG PC F+ PR ++ ++ L
Sbjct: 117 SEALQTYEKNMPNHVFIHEKDIRKIK--EFPSANLVIGGFPCPGFSEAGPRLVDDERNFL 174
Query: 98 YRDPIGRLVLEFVRFVERLKPKVFVMENVPQIM-----ELEKYLRKEFDKAGYDIYFNVL 152
Y + F+R + +++P++FV ENV +M E+ + + ++F AGY + +L
Sbjct: 175 Y--------IHFIRCLMQVQPEIFVAENVKGMMTLGGGEVFRQIVEDFGAAGYRVEARLL 226
Query: 153 NALDYGAPQVRRRVFISNLEL--------------KPKKIKGPRKVWDALKNIPIDAPNH 198
NA DYG PQ+R RV I + + +K + +A+ ++ +D +
Sbjct: 227 NARDYGVPQIRERVIIVGVRNDIDFNYEYPEITHGNEEGLKPYVTLEEAIGDLSLDPGPY 286
Query: 199 DFWSPPSKIARRIPRLRWGEGA---QRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFED-- 253
S + R + +W + + Q GR Q I L P V N E+
Sbjct: 287 FTGSYSTIFMSRNRKKKWTDQSFTIQASGR-QAPIHLGGL-PMEKVDKNKWIFPDGEENH 344
Query: 254 RPLTVREQARLMGFPDDFVFLGGRNV----------QFDSVGEAVPPPLAKAIANFI 300
R L+V+E R+ FPD + F G N+ Q+ +G AVP L +A+A I
Sbjct: 345 RRLSVKEIKRIQTFPDWYEFSDGGNMKVSVNNRLDKQYKQIGNAVPVFLTRAVAKSI 401
>emb|CAA33765.1| (X15758) methylase [Bacillus sphaericus]
Length = 396
Score = 99.8 bits (245), Expect = 4e-20
Identities = 98/357 (27%), Positives = 155/357 (42%), Gaps = 75/357 (21%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVG----------------------------FEIVAAIENF 38
+ VL LF GAGG LGF+L G F V A + F
Sbjct: 29 KFNVLSLFCGAGGLDLGFELAGLEQSLGTDKALEAFKDRDVYNAIRHESVFHTVYANDIF 88
Query: 39 KPKAKTYSHNFPG-VKVIAQDIKVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRL 97
+TY N P V + +DI+ I E +++IGG PC F+ PR ++ ++ L
Sbjct: 89 SEALQTYEKNMPNHVFIHEKDIRKIK--EFPSANLVIGGFPCPGFSEAGPRLVDDERNFL 146
Query: 98 YRDPIGRLVLEFVRFVERLKPKVFVMENVPQIM-----ELEKYLRKEFDKAGYDIYFNVL 152
Y + F+R + +++P++FV ENV +M E+ + + ++F AGY + +L
Sbjct: 147 Y--------IHFIRCLMQVQPEIFVAENVKGMMTLGGGEVFRQIVEDFGAAGYRVEARLL 198
Query: 153 NALDYGAPQVRRRVFISNLEL--------------KPKKIKGPRKVWDALKNIPIDAPNH 198
NA DYG PQ+R RV I + + +K + +A+ ++ +D +
Sbjct: 199 NARDYGVPQIRERVIIVGVRNDIDFNYEYPEITHGNEEGLKPYVTLEEAIGDLSLDPGPY 258
Query: 199 DFWSPPSKIARRIPRLRWGEGA---QRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFED-- 253
S + R + +W + + Q GR Q I L P V N E+
Sbjct: 259 FTGSYSTIFMSRNRKKKWTDQSFTIQASGR-QAPIHLGGL-PMEKVDKNKWIFPDGEENH 316
Query: 254 RPLTVREQARLMGFPDDFVFLGGRNV----------QFDSVGEAVPPPLAKAIANFI 300
R L+V+E R+ FPD + F G N+ Q+ +G AVP L +A+A I
Sbjct: 317 RRLSVKEIKRIQTFPDWYEFSDGGNMKVSVNNRLDKQYKQIGNAVPVFLTRAVAKSI 373
>pir||I40424 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - Bacillus
stearothermophilus >gi|2126853|pir||S68583 DNA
(cytosine-5-)-methyltransferase (EC 2.1.1.37) - Bacillus
stearothermophilus >gi|7474391|pir||S61228 DNA
(cytosine-5-)-methyltransferase (EC 2.1.1.37) - Bacillus
stearothermophilus >gi|967022|emb|CAA62381.1| (X90873)
DNA (cytosine-5-)-methyltransferase [Bacillus
stearothermophilus] >gi|1262297|gb|AAA96793.1| (U51733)
m5C-multispecific methyltransferase [Bacillus
stearothermophilus] >gi|1589631|prf||2211376A
cytosine-C5-DNA methyltransferase [Bacillus
stearothermophilus]
Length = 534
Score = 99.5 bits (244), Expect = 5e-20
Identities = 57/166 (34%), Positives = 87/166 (52%), Gaps = 13/166 (7%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
+ V +LFAG G ++G + G+ +V A + K Y HN G ++ DI I P +I
Sbjct: 14 LTVAELFAGGGLMAVGLRAAGYNLVWANDFDKSACAAYRHNL-GDHIVHGDITAIDPADI 72
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
D DVI GGPPC+ ++ E + G+LV ++R +E +PK F+ ENV
Sbjct: 73 PDTDVIAGGPPCQDYSVAGTGAGEEGER-------GKLVWAYLRIIEAKRPKAFIFENVK 125
Query: 128 QIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
++ + L K+F GY++ + ++NA DYG Q R RVFI
Sbjct: 126 GLITKKHRPTFDALLKQFKIIGYNVSWKLINAWDYGVAQKRERVFI 171
>sp|P24581|MTNX_NEILA CYTOSINE-SPECIFIC METHYLTRANSFERASE NLAX (M.NLAX)
>gi|66471|pir||XYNHCL site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
NlaX - Neisseria lactamica >gi|45004|emb|CAA38357.1|
(X54485) cytosine-specific methyltransferase of NlaIII
[Neisseria lactamica]
Length = 313
Score = 96.0 bits (235), Expect = 5e-19
Identities = 88/315 (27%), Positives = 137/315 (42%), Gaps = 29/315 (9%)
Query: 9 KVLDLFAGAGGFSLGFKLVGFEI--VAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDE 66
K++DLFAG GG LGF+ ++ V + E K +TY N G + + DI +
Sbjct: 3 KIIDLFAGIGGIRLGFEQAFDDVRCVFSSEIDKYAVQTYQANHGG-ETVCGDITQTDVAD 61
Query: 67 IGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
I D D++ G PC+PF+ ++ + D G L + R + KP+ F++ENV
Sbjct: 62 IPDHDILSAGFPCQPFSQAGLKKG-------FADTRGTLFFDIERILLAKKPQAFLLENV 114
Query: 127 PQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI-----SNLELK-P 175
Q+ +K + +AGY +Y VL A D+G PQ R R+++ +++ + P
Sbjct: 115 KQLKGHDKGRTLQVILAHLQQAGYKVYTEVLKARDFGIPQNRERIYLVGFLNHDVDFRFP 174
Query: 176 KKIKGPRKVWDALKNIPID--APNHDFWS--PPSKIARRIPRLRWGEGA-QRFGRFQNWI 230
+ I V D L+ P + + W K R +G G + N I
Sbjct: 175 QPIGQATAVGDILEAYPDEKYTISDKLWQGYQRRKAENRAAGKGFGYGLFNAESAYTNTI 234
Query: 231 RLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPP 290
YK + +P R +T E ARL GFPD F + G +V
Sbjct: 235 SARYYKDGSEILIEQPGKNP---RKITPPEAARLQGFPDSFQIPVSDAQAYRQFGNSVCV 291
Query: 291 PLAKAIANFIFDVLS 305
P+ +AIA + LS
Sbjct: 292 PVIRAIAEQMKAALS 306
>pir||B39467 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) HgaI 1 [validated] - Haemophilus
paragallinarum >gi|216711|dbj|BAA14377.1| (D90363) HgaI
methylase [Haemophilus paragallinarum]
>gi|435623|dbj|BAA04206.1| (D17388) HgaI methylase 1
[Haemophilus paragallinarum] >gi|1090538|prf||2019268A
HgaI restriction methylase:ISOTYPE=1 [Haemophilus
paragallinarum]
Length = 365
Score = 96.0 bits (235), Expect = 5e-19
Identities = 97/360 (26%), Positives = 154/360 (41%), Gaps = 70/360 (19%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI------ 59
K + L LF+ AG VG +I+ A E K +A Y +P K++ DI
Sbjct: 11 KNIMGLSLFSSAGIGEYFLSRVGIDIIVANELIKKRADLYQKIYPNHKMVIGDIRDQRIF 70
Query: 60 -KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKP 118
KV++ VD +I PPC+ + R + + D L++ + +++LKP
Sbjct: 71 NKVLNIALTNQVDFLIASPPCQGMSVAGKNRDVS---NMANDNRNYLIMYVIAMIKKLKP 127
Query: 119 KVFVMENVPQIMELEKYLRKEF--------DKAG--YDIYFNVLNALDYGAPQVRRRVFI 168
++ENVP +++LE Y+ + D+ G Y I+F++L+A DYG PQ R+R I
Sbjct: 128 AYILIENVPFLLKLELYIDNKLTPIKNILEDEFGSEYHIHFDILDAADYGTPQRRKRAII 187
Query: 169 S--------NLELKPKKIKGPRKVWDALKNIP-IDAPNHD--FW---------------- 201
NL LK + V A+ N+P I++ H W
Sbjct: 188 RLNKKGTIWNLPLKQNIV----SVEQAIGNLPSIESGKHSGLKWHYGRGHTEQQIEWMKH 243
Query: 202 SPPSKIA--RRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPTVR------GNSRFVHP--- 250
+P K A + R G + G ++ R+ +PAPT+ + R VHP
Sbjct: 244 TPTGKSAFENLVHYPRKANGEKVKGYHSSYRRIRWDEPAPTITIRNDAISSQRNVHPGRP 303
Query: 251 ------FEDRPLTVREQARLMGFPDDFVFLGG--RNVQFDSVGEAVPPPLAKAIANFIFD 302
+ R L+V E RL G PD++ + +GE +PP L + I IF+
Sbjct: 304 LLDGTYSDARVLSVLELMRLTGLPDNWEIPDDTPEILIRQIIGECIPPLLIENITREIFN 363
>sp|P25282|MTG1_HAEGA MODIFICATION METHYLASE HGAI-1 (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HGAI-1) (M.HGAI-1)
Length = 357
Score = 96.0 bits (235), Expect = 5e-19
Identities = 97/360 (26%), Positives = 154/360 (41%), Gaps = 70/360 (19%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI------ 59
K + L LF+ AG VG +I+ A E K +A Y +P K++ DI
Sbjct: 3 KNIMGLSLFSSAGIGEYFLSRVGIDIIVANELIKKRADLYQKIYPNHKMVIGDIRDQRIF 62
Query: 60 -KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKP 118
KV++ VD +I PPC+ + R + + D L++ + +++LKP
Sbjct: 63 NKVLNIALTNQVDFLIASPPCQGMSVAGKNRDVS---NMANDNRNYLIMYVIAMIKKLKP 119
Query: 119 KVFVMENVPQIMELEKYLRKEF--------DKAG--YDIYFNVLNALDYGAPQVRRRVFI 168
++ENVP +++LE Y+ + D+ G Y I+F++L+A DYG PQ R+R I
Sbjct: 120 AYILIENVPFLLKLELYIDNKLTPIKNILEDEFGSEYHIHFDILDAADYGTPQRRKRAII 179
Query: 169 S--------NLELKPKKIKGPRKVWDALKNIP-IDAPNHD--FW---------------- 201
NL LK + V A+ N+P I++ H W
Sbjct: 180 RLNKKGTIWNLPLKQNIV----SVEQAIGNLPSIESGKHSGLKWHYGRGHTEQQIEWMKH 235
Query: 202 SPPSKIA--RRIPRLRWGEGAQRFGRFQNWIRLHPYKPAPTVR------GNSRFVHP--- 250
+P K A + R G + G ++ R+ +PAPT+ + R VHP
Sbjct: 236 TPTGKSAFENLVHYPRKANGEKVKGYHSSYRRIRWDEPAPTITIRNDAISSQRNVHPGRP 295
Query: 251 ------FEDRPLTVREQARLMGFPDDFVFLGG--RNVQFDSVGEAVPPPLAKAIANFIFD 302
+ R L+V E RL G PD++ + +GE +PP L + I IF+
Sbjct: 296 LLDGTYSDARVLSVLELMRLTGLPDNWEIPDDTPEILIRQIIGECIPPLLIENITREIFN 355
>pir||A81101 C-5 cytosine-specific DNA-methylase NMB1290 [imported] - Neisseria
meningitidis (group B strain MD58, group A strain Z2491)
>gi|7226530|gb|AAF41666.1| (AE002477) C-5
cytosine-specific DNA-methylase [Neisseria meningitidis
MC58] >gi|7380148|emb|CAB84733.1| (AL162756) putative
modification methylase [Neisseria meningitidis Z2491]
Length = 337
Score = 96.0 bits (235), Expect = 5e-19
Identities = 88/328 (26%), Positives = 146/328 (43%), Gaps = 32/328 (9%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNF---PGVKVIAQDIKV 61
N++ +DLFAG GGF + + VG V + E +TY NF P + ++ K
Sbjct: 17 NEKFTFIDLFAGIGGFRIAMENVGGRCVFSSEWDDKARQTYQVNFNDIPYGDITLKETKA 76
Query: 62 ISPDEIGDVDVIIGGPPCEPFTAINPRRKEN-PKDRLYRDPI-GRLVLEFVRFVERLKPK 119
P + DV+ G PC+PF+ +K++ ++ + D G L + + + +PK
Sbjct: 77 AIPSKF---DVLTAGFPCQPFSIAGVSKKKSLGRETGFLDKAQGTLFFDVAEIIGKHRPK 133
Query: 120 VFVMENVPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK 174
+F++ENV ++ + K ++ ++ Y I++ V+NA Y PQ R R+FI + +
Sbjct: 134 IFLLENVKNLVSHDKGNTFKVIKGTLEELDYQIFYQVMNA-KYYVPQNRERIFIVGFDRQ 192
Query: 175 --PKKIK----GPRKVWDALKNIPIDAPNHDF------WSPPSKIAR--RIPRLRWGEGA 220
K+I P + LK I D ++ F W A+ + +G G
Sbjct: 193 YFNKEINFNFPSPPESQPKLKQILEDDVDNSFTLSDNLWLYLQNYAKKHKAKGNGFGFGL 252
Query: 221 QRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVF-LGGRNV 279
+ YK + + +P R LT RE +RLMGFP DFV +
Sbjct: 253 VDLDGISRTLSARYYKDGSEILIPQKGKNP---RKLTPRECSRLMGFPKDFVIDAVSKTA 309
Query: 280 QFDSVGEAVPPPLAKAIANFIFDVLSKE 307
+ G ++ PL +AIA I + L E
Sbjct: 310 AYKQFGNSIAVPLVQAIAKQIINELKNE 337
>gi|10955252 DNA-methyltransferase [Escherichia coli] >gi|1237268|gb|AAC37145.1|
(L76268) eco29kIM [Escherichia coli]
>gi|2660513|emb|CAA04944.1| (AJ001708)
DNA-methyltransferase [Escherichia coli]
Length = 382
Score = 95.6 bits (234), Expect = 7e-19
Identities = 91/381 (23%), Positives = 150/381 (38%), Gaps = 90/381 (23%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
M+ L++F+GAGG + G +L GF+ V +E K + NF KV DIK +
Sbjct: 1 MRSLEIFSGAGGLAKGLELAGFQHVGFVELNKHACDSLRLNFDEEKVFQGDIKNYDLSSL 60
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
+D++ GGPPC+PF+ + + ++ P ++ +E L+PK F+ ENV
Sbjct: 61 DKIDIVAGGPPCQPFSLGGKHKAHDDSRDMF--PFA------IKAIEVLQPKAFIFENVK 112
Query: 128 QIME---------------------------------LEKYLRKEFDKAGYDIYFNVLNA 154
++ L K + + YD+ F ++NA
Sbjct: 113 GLLRKSFADYFEYIILRLTYPCLSLSNVSDWRIHLDVLRKARKDKHCGCTYDVSFKLINA 172
Query: 155 LDYGAPQVRRRVFI----SNLELK---PKKIKGPRK-VWD-------------------- 186
DYG PQ+R RV I S+L K P K +W+
Sbjct: 173 ADYGVPQIRERVIIVGVRSDLNKKWSFPSVTHTQEKLLWEQHVTGDYWRKHNIDAVIDKG 232
Query: 187 ----ALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYK------ 236
+K I P+ W + +P+ G F++ R++P
Sbjct: 233 ISERLMKRFGIFPPSGKSWVTVRDALKNVPQPYESHGIGDH-IFKDGARVYPGHTGSYID 291
Query: 237 -PAPTVRGNSRFVHPFED---------RPLTVREQARLMGFPDDFVFLGGRNVQFDSVGE 286
P+ T++ + V E+ R TV E L FP +F+ G +G
Sbjct: 292 LPSKTLKAGAHGVPGGENMIRYEDGTVRYFTVYEGKLLQTFPREFLIAGAWGEAMRQIGN 351
Query: 287 AVPPPLAKAIANFIFDVLSKE 307
AVP LA+ I ++++L++E
Sbjct: 352 AVPVLLAQKIGQQLYNLLNEE 372
>emb|CAB46561.1| (AJ242480) putative cytosine-specific methyl transferase
[Streptococcus thermophilus]
Length = 316
Score = 95.2 bits (233), Expect = 9e-19
Identities = 88/321 (27%), Positives = 134/321 (41%), Gaps = 39/321 (12%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
+ V FAG GG LGF+ GF+ + A E A T+ NF V V +DI + ++I
Sbjct: 2 LTVASFFAGVGGIDLGFEKAGFKTIYANEFDNYAADTFELNF-DVTVDRRDINTVPAEDI 60
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
+ DV++ G PC+ F+ R+ N + G L E VR ++ KP++ ENV
Sbjct: 61 PNFDVMLAGFPCQAFSIAGYRQGFNDEQGR-----GNLFFELVRILKAKKPRIAFFENVK 115
Query: 128 QIMELE-----KYLRKEFDKAGYDIYFNVLNALDYG-APQVRRRVFISNLELKPKKIKGP 181
++ + + + E DK GY F V+NA DYG PQ R R++I + K
Sbjct: 116 NLVSHDNGNTFRVICSELDKLGYKYLFQVMNAADYGNIPQNRERIYIVAF-----RDKED 170
Query: 182 RKVWDALKNIPIDAPNHDFWSPPSKIARRIPRL--------RWGEGAQRFGRFQNW---- 229
+D K+IP++ D SK+ + E + W
Sbjct: 171 YADFDLPKSIPLETSIKDVIDFDSKVDDKFYYTAEKNKFFDELKENMTKSDTTYQWRRVY 230
Query: 230 IRLHPYKPAPTVRGNSR---------FVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQ 280
+R + PT+ N + E R LT RE + GFP D+ N +
Sbjct: 231 VRENKSNLVPTLTANMGTGGHNVPLILTNSKEIRKLTPRECFNVQGFPKDYKLPEQSNSR 290
Query: 281 -FDSVGEAVPPPLAKAIANFI 300
+ G +V P+ IA I
Sbjct: 291 LYKQAGNSVTVPVIDRIAKNI 311
>gb|AAC49849.1| (AF025475) Masc1 [Ascobolus immersus]
Length = 537
Score = 93.6 bits (229), Expect = 3e-18
Identities = 85/317 (26%), Positives = 129/317 (39%), Gaps = 59/317 (18%)
Query: 12 DLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEIG--- 68
D F G GG SLG + G E+ A + Y NFP + + +G
Sbjct: 231 DTFCGGGGVSLGARQAGLEVKWAFDMNPNAGANYRRNFPNTDFFLAEAEQFIQLSVGISQ 290
Query: 69 DVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQ 128
VD++ PPC+ F+ + +N ++ V ++ ++P++F +E
Sbjct: 291 HVDILHLSPPCQTFSRAHTIAGKNDENN------EASFFAVVNLIKAVRPRLFTVEETDG 344
Query: 129 IMELEKYLRKEFDKA-------GYDIYFNVLNALDYGAPQVRRRVFISNL----ELKPKK 177
IM+ + R+ D A GY VLNA++YG Q R+R+ I EL P
Sbjct: 345 IMDRQS--RQFIDTALMGITELGYSFRICVLNAIEYGVCQNRKRLIIIGAAPGEELPPFP 402
Query: 178 I--------KGPRK-------VWDALKNIPIDAPNHDF---WSPPSKIARRIPRLRWGEG 219
+ K PR+ + DAL I ++ +H W P W
Sbjct: 403 LPTHQDFFSKDPRRDLLPAVTLDDALSTITPESTDHHLNHVWQPAE----------WKTP 452
Query: 220 AQRFGRFQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNV 279
F+N IR G ++P R TVRE A + GFPD++ F+G
Sbjct: 453 YDAHRPFKNAIR---------AGGGEYDIYPDGRRKFTVRELACIQGFPDEYEFVGTLTD 503
Query: 280 QFDSVGEAVPPPLAKAI 296
+ +G AVPPPL+ AI
Sbjct: 504 KRRIIGNAVPPPLSAAI 520
>pir||JC4986 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) ApaLI - Acetobacter pasteurianus
>gi|1644234|dbj|BAA11339.1| (D78276) ApaLI methylase
[Acetobacter pasteurianus]
Length = 429
Score = 93.2 bits (228), Expect = 4e-18
Identities = 60/176 (34%), Positives = 84/176 (47%), Gaps = 22/176 (12%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP 64
NK V+ LFAGAGGFS GF G + + E +TY N G D+ + P
Sbjct: 2 NKDEVVVSLFAGAGGFSSGFSQAGLKPLFGAEINADACQTYQENV-GSPCHQLDLSTVDP 60
Query: 65 DEIGDVD------VIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKP 118
I + V+IGGPPC+ F+ PR + DP L+ ++ VERL P
Sbjct: 61 SHIEMLTGGKRPFVVIGGPPCQGFSTAGPRN--------FADPRNLLIFNYLNIVERLSP 112
Query: 119 KVFVMENVPQIM------ELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
+ F+ ENV ++ +L + +R EF GY + +N YG PQ R+RV I
Sbjct: 113 RWFIFENVEGLLTSGGGRDLARLVR-EFVDMGYSVRLQKVNLAAYGVPQTRKRVLI 167
>gb|AAC45757.1| (AF020002) M.BssHII methylase [Bacillus stearothermophilus]
Length = 375
Score = 93.2 bits (228), Expect = 4e-18
Identities = 56/186 (30%), Positives = 92/186 (49%), Gaps = 27/186 (14%)
Query: 1 MGEGNKRMKVLDLFAGAGGFSLG-----FKLVGFEIVAAIENFKPKAKTYSHNFPG-VKV 54
+G G + + LF+GAGG +G +K + E + ++N+K T + G V
Sbjct: 152 LGYGKRNLTAFSLFSGAGGLDIGAEQATYKSMKIETLVTLDNWKDACDTLRGFYQGRTSV 211
Query: 55 IAQDIKVISPDEI---------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRL 105
+ DI I ++ D++ GGPPC+ F+ ++ N DP G L
Sbjct: 212 LQGDISEIQDPKLLWHQESQHDQIPDIVFGGPPCQAFSQAGKQKATN-------DPRGNL 264
Query: 106 VLEFVRFVERLKPKVFVMENVPQIM-----ELEKYLRKEFDKAGYDIYFNVLNALDYGAP 160
+ E++RF+E++ P FVMENV + EL + + + GY++ L A DYGAP
Sbjct: 265 IYEYLRFIEKINPPFFVMENVANLKGVQRGELYQDILERMSNLGYNVTVAPLLAADYGAP 324
Query: 161 QVRRRV 166
Q+R+R+
Sbjct: 325 QLRKRL 330
Score = 70.2 bits (169), Expect = 3e-11
Identities = 48/123 (39%), Positives = 60/123 (48%), Gaps = 23/123 (18%)
Query: 197 NHDFWSPPSKIARRIPRLRWGEGAQ---------------------RFGRFQNWIRLHPY 235
NH F S++ +RI L+ G+ Q R G IRL P
Sbjct: 19 NHVFRRSGSEVQKRIDALKIGQKMQDLPEELWHDSFRYYVKEDPNRRGGPNMRMIRLDPS 78
Query: 236 KPAPTVRGN--SRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLA 293
KP+ TV G ++FVHP+E+R +TVRE ARL GFPD F G VG AVP LA
Sbjct: 79 KPSLTVTGYIFNKFVHPYENRFITVREAARLQGFPDSLKFEGSLTSTQMQVGNAVPVQLA 138
Query: 294 KAI 296
KA+
Sbjct: 139 KAV 141
>sp|P09795|MTSI_SALIN MODIFICATION METHYLASE SINI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
SINI) (M.SINI) >gi|79032|pir||A32008 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
- Salmonella sp >gi|154350|gb|AAA27212.1| (J03391)
modification methylase (M.SinI) [Salmonella infantis]
Length = 461
Score = 92.8 bits (227), Expect = 5e-18
Identities = 93/376 (24%), Positives = 150/376 (39%), Gaps = 77/376 (20%)
Query: 3 EGNKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVI 62
E + K L F+GA G LG + GFE + A E K T N P + +I DI+
Sbjct: 70 EPKNKPKALSFFSGAMGLDLGIEQAGFETLLASEIDKAARDTILSNRPNMALIG-DIRDY 128
Query: 63 SPDEI---------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFV 113
+ ++I ++D+I+GGPPC+ F+ R D G + ++++
Sbjct: 129 TTEDILKLAGVSSGNEIDLIMGGPPCQAFSTAGKRLG-------LEDERGNVFIKYLDVA 181
Query: 114 ERLKPKVFVMENV--------------------PQIMELEK------YLRKEFDKAGYDI 147
++PK V+ENV P + E+ Y+ + AGY +
Sbjct: 182 LDIRPKYIVIENVRGLLSAPMKHRPHNERGEGLPPLKSEEQPGGVLHYIIRIIKSAGYSV 241
Query: 148 YFNVLNALDYGAPQVRRRVFISNLE-------LKP---KKIKGPRKVWDALKNIPIDAPN 197
FN+ N+ ++G PQ+R RV I L+P +K + W L+ + N
Sbjct: 242 SFNLYNSANFGVPQIRERVIIICSRDGSRVPFLQPTHSEKGEYGLPKWITLRETITNLKN 301
Query: 198 --HDFWSPPSKIARRIPRLRWGE----------------------GAQRFGRFQNWIRLH 233
H+ P K + L+ G+ G F R W R
Sbjct: 302 ITHEHVLFPEKRLKYYRLLKEGQYWKHLPEDLQKEALGKSFFLGGGKTGFLRRVAWDRPS 361
Query: 234 PYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLA 293
P + HP E RPL+V+E + FP+++V G ++ +G AVP L
Sbjct: 362 PTLVTHPAMPATDLAHPDELRPLSVQEYKVIQQFPEEWVIKGKLLDKYRQLGNAVPIGLG 421
Query: 294 KAIANFIFDVLSKERI 309
A+ I D ++ +I
Sbjct: 422 LAVGKNILDHMNGRKI 437
>sp|P50185|MTD5_DACSA MODIFICATION METHYLASE DSAV (CYTOSINE-SPECIFIC METHYLTRANSFERASE
DSAV) (M.DSAV) >gi|1086022|pir||S50098 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
DsaV - Dactylococcopsis salina sp. nov. (DSM 4880)
>gi|505694|gb|AAA86046.1| (U10528) DsaV
methyltransferase [Dactylococcopsis salina]
Length = 351
Score = 91.3 bits (223), Expect = 1e-17
Identities = 84/314 (26%), Positives = 138/314 (43%), Gaps = 37/314 (11%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
K++K +DLFAG GG + F+ +G + V + E K +TY NF ++ DI +S D
Sbjct: 4 KQLKFIDLFAGIGGMRIPFEELGGKCVFSSEIDKHCQRTYEANFG--EMPTGDITKLSAD 61
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
I D+++ G PC+ F+ + + + ++D G+L + + + +P+ ++EN
Sbjct: 62 SIPYHDLLLAGFPCQAFS-------QGGRKQGFQDERGQLFFQVAKILNDHRPQAILLEN 114
Query: 126 VPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK------ 174
V + +K + +K Y + + +++A D+ PQ R R+FI + K
Sbjct: 115 VKGLRGHDKGRTLQMILYVLEKLNYVVSWKIISATDFNLPQKRERIFIVGFQDKNNKNLI 174
Query: 175 ---PKKIKGPRKVWDALKNIPIDAP---NHDFWSPPSKIARRIPRLRWGEG-----AQRF 223
PK I+ KV D L+ +D W R+ + G G R
Sbjct: 175 FDFPKPIELTAKVGDLLEK-EVDEKYTITDRMWEGHQN--RKKAHRKRGNGFGFSLVNRN 231
Query: 224 GRFQNWIRLHPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDS 283
+ I YK V +P R LT RE ARL GFP+ FV +
Sbjct: 232 SSYTRTISARYYKDGSEVLVEQANKNP---RVLTPRECARLQGFPESFVIPVSDCQAWRQ 288
Query: 284 VGEAVPPPLAKAIA 297
G +VP + +AIA
Sbjct: 289 FGNSVPVSVIRAIA 302
>sp|P43420|MTB6_BACSP MODIFICATION METHYLASE BSP6I (CYTOSINE-SPECIFIC METHYLTRANSFERASE
BSP6I) (M.BSP6I) >gi|2126837|pir||I40138 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
- Bacillus sp >gi|547481|emb|CAA57293.1| (X81638)
site-specific DNA-methyltransferase (cytosine-specific)
[Bacillus sp.] >gi|1098125|prf||2115268B
methyltransferase Bsp6IM [Bacillus sp.]
Length = 315
Score = 91.3 bits (223), Expect = 1e-17
Identities = 91/321 (28%), Positives = 147/321 (45%), Gaps = 38/321 (11%)
Query: 8 MKVLDLFAGAGGFSLGFKLVG-FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDE 66
+++ LFAG GG LGF+ G FE V A E K A TY NF K+I DI+ I ++
Sbjct: 2 LQIASLFAGVGGIDLGFEQTGYFETVWANEYDKNAAITYQSNFKN-KLIIDDIRNIKVED 60
Query: 67 IGDVDVIIGGPPCEPFTAINPRRK-ENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
+ D DV++ G PC F+ R+ E+ K G L E +R + KP+V +EN
Sbjct: 61 VPDFDVLLSGFPCTSFSVAGYRKGFEDEKS-------GDLFFETLRLIVAKKPQVIFLEN 113
Query: 126 VPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYG-APQVRRRVFI---SNLE-LKP 175
V ++ + K + + + GY I + VLNA D+G PQ R R++I N+E K
Sbjct: 114 VKNLVGHDNGNTFKVIYEALESNGYHIKYQVLNAKDFGNIPQNRERIYIVGFRNIEHYKN 173
Query: 176 KKIKGPRKVWDALKNI--PIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRF-QNWIRL 232
P+ + +K++ D + F+ K + P + ++ + ++R
Sbjct: 174 FNFPMPQPLTLTIKDMINLSDKLDDRFYYTEDKCSFYSPLQEQMTSDETIYQWRRKYVRE 233
Query: 233 HPYKPAPTVRGNS----------RFVHPFEDRPLTVREQARLMGFPDDFVF--LGGRNVQ 280
+ PT+ N + H R LT RE G+P+DF+ L ++
Sbjct: 234 NKSNVCPTLTANMGTGGHNVPLVKTKHGI--RKLTPRECFNFQGYPEDFILPELAPTHL- 290
Query: 281 FDSVGEAVPPPLAKAIANFIF 301
+ G +V P+ + IA I+
Sbjct: 291 YKQAGNSVVVPVIRRIAENIY 311
>gb|AAC97180.1| (AF044847) ApaLI methyltransferase [Acetobacter pasteurianus]
Length = 429
Score = 90.9 bits (222), Expect = 2e-17
Identities = 59/176 (33%), Positives = 83/176 (46%), Gaps = 22/176 (12%)
Query: 5 NKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP 64
NK V+ LFAGAGGFS GF G + + E +TY N G D+ + P
Sbjct: 2 NKDEVVVSLFAGAGGFSSGFSQAGLKPLFGAEINADACQTYQENV-GSPCHQLDLSTVDP 60
Query: 65 DEIGDVD------VIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKP 118
I + V+IGGPPC+ F+ PR + DP L+ ++ VERL P
Sbjct: 61 SHIEMLTGGKRPFVVIGGPPCQGFSTAGPRN--------FADPRNLLIFNYLNIVERLSP 112
Query: 119 KVFVMENVPQIM------ELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
+ + ENV ++ +L + +R EF GY + +N YG PQ R+RV I
Sbjct: 113 RWLIFENVEGLLTSGGGRDLARLVR-EFVDMGYSVRLQKVNLAAYGVPQTRKRVLI 167
>sp|P34905|MTB1_BACBR MODIFICATION METHYLASE BBVI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
BBVI) (M.BBVI)
Length = 374
Score = 90.5 bits (221), Expect = 2e-17
Identities = 88/349 (25%), Positives = 143/349 (40%), Gaps = 63/349 (18%)
Query: 12 DLFAGAGGFSLGFK-----------LVGFEIVAAIENFKPKAKTYSHNFPGVK---VIAQ 57
+LF G GG +LG K + FE A + + +T+ N + V+
Sbjct: 7 ELFCGPGGLALGAKEAKYMHPETGEVFEFEHAWANDIDEWACETFRTNICPDRPDSVVCG 66
Query: 58 DIKVIS----PDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFV 113
D++ + ++ G++D G PC ++ + + G L V+ +
Sbjct: 67 DVRELDIKSLGEKFGEIDAFTFGFPCNDYSIVGEHKGMEGN-------YGPLYSYGVKIL 119
Query: 114 ERLKPKVFVMENVPQIMELEKYLRKEF----------DKAGYDIYFNVLNALDYGAPQVR 163
P VF+ ENV + + K F K GY + ++ +YG PQ R
Sbjct: 120 NEYNPLVFIAENVGGLQSANE--GKAFLGILNDLASAGKYGYKLVPHLYKFEEYGVPQRR 177
Query: 164 RRVFISNLEL---------KPKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRL 214
R+ I + +P + R +AL +IP DA NH+F K+ + +
Sbjct: 178 HRIIIVGIRKDQDVAFRVPEPTHKEKYRTASEALADIPEDALNHEFTRHKKKVVEMLNHI 237
Query: 215 R-----WGEG--------AQRFGRFQNWIRLHPYKPAPTVRGN----SRFVHPFEDRPLT 257
W E ++ Q + RLHP +P+ TV G+ + H E R LT
Sbjct: 238 APGGNAWSESIPEELRLNVKKVRMSQIYRRLHPDQPSYTVTGSGGGGTHGYHWEEPRALT 297
Query: 258 VREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLAKAIANFIFDVLSK 306
RE+ARL FPDD+ F+G + + +G AVPP AK I + ++
Sbjct: 298 NRERARLQTFPDDYEFIGKKEMVRKQIGMAVPPDGAKIILEAVLKTFAR 346
>gb|AAB21481.2| (S86113) cytosine DNA methyltransferase homolog [Neisseria
gonorrhoeae]
Length = 347
Score = 90.5 bits (221), Expect = 2e-17
Identities = 73/258 (28%), Positives = 113/258 (43%), Gaps = 39/258 (15%)
Query: 1 MGEGNKRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIK 60
+ + + K+L LF+G GG LGF G E V A + +++ N V ++ DI+
Sbjct: 9 LNSSSNKPKILSLFSGCGGLYLGFHQAGCETVWANDFSHWACESFRKNIGDV-IVEGDIE 67
Query: 61 VISPDE--IGDVDVIIGGPPCEPFTAI-NPRRKENPKDRLYRDPIGRLVLEFVRFVERLK 117
I+P++ I D D+I+GG PC+ F+ I E + LY+ F+RFV K
Sbjct: 68 QINPNDPTIPDCDIILGGFPCQDFSMIWKQPGLEGERGNLYKS--------FLRFVNAKK 119
Query: 118 PKVFVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLE 172
PKVFV ENV ++ K + +F+ GY + + N ++G PQ R RV I +
Sbjct: 120 PKVFVAENVKGLLTANKKKAIQQIITDFENCGYYVQAKLYNFAEFGVPQFRERVLIVGVR 179
Query: 173 LK----------------PKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRW 216
L +K A+ NIP +A N++ K R +
Sbjct: 180 LDTGFDFRHPEPTHNETGENGLKPYVTAGQAISNIPQNASNNELLKISGKTRRMFELIPE 239
Query: 217 GEGAQRFGRFQNWIRLHP 234
G G F + + HP
Sbjct: 240 G------GNFTDIPKDHP 251
>gb|AAC98421.1| (L29323) methyl transferase [Streptococcus pneumoniae]
Length = 452
Score = 90.1 bits (220), Expect = 3e-17
Identities = 58/171 (33%), Positives = 87/171 (49%), Gaps = 17/171 (9%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIA-QDIKVISPDE 66
M+ +DLF+G GGF LG + VG E + E K ++Y F I DI+ +S DE
Sbjct: 1 MRFIDLFSGIGGFRLGMESVGHECIGFCEIDKFARESYKSIFQTEGEIEFHDIRDVSDDE 60
Query: 67 I----GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFV 122
G VDVI GG PC+ F+ R + D G L E R ++++P+
Sbjct: 61 FKKLRGKVDVICGGFPCQAFSIAGRRLG-------FEDTRGTLFFEIARAAKQIQPRFLF 113
Query: 123 MENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
+ENV ++ +K + D+ G+D+ + +LN+ D+G PQ R RVFI
Sbjct: 114 LENVKGLLNHDKGRTFTTILTTLDELGFDVEWQMLNSKDFGVPQNRERVFI 164
>sp|P17044|MTBF_BACSU MODIFICATION METHYLASE BSUFI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
BSUFI) (M.BSUFI) >gi|66473|pir||CTBSFI site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
BsuFI - Bacillus subtilis (strain ISF18)
>gi|39984|emb|CAA35888.1| (X51515) methyltransferase
M.BsuFI (AA 1-409) [Bacillus subtilis]
Length = 409
Score = 88.9 bits (217), Expect = 7e-17
Identities = 82/304 (26%), Positives = 142/304 (45%), Gaps = 24/304 (7%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDE 66
++ +DLFAG GG LGF+ + V + E K A+TY N+ G K DI I+ ++
Sbjct: 100 KLTFIDLFAGIGGIRLGFEDKYTKCVFSSEWDKYAAQTYEANY-GEKPHG-DITKINEND 157
Query: 67 IGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
I D DV++ G PC+PF+ I R + R ++ + +R +++ +PK+F++ENV
Sbjct: 158 IPDQDVLLAGFPCQPFSNIGKREGFAHERR-------NIIFDVLRILKKKQPKMFLLENV 210
Query: 127 PQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNL--ELKPKKIK 179
++ + + + GY +++ V++A ++G PQ R R+ I +L
Sbjct: 211 KGLLTNDNGNTFRVILDNLKSLGYSVFYEVMDAQNFGLPQRRERIVIVGFHPDLGINDFS 270
Query: 180 GPRKVWDALKNIPIDA--PNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPYKP 237
P+ D +PI+A ++ SK + + +G + F+ +++
Sbjct: 271 FPKGNPD--NKVPINAILEHNPTGYSISKRLQESYLFKKDDGKPQIVDFRCTYQVNTLVA 328
Query: 238 A--PTVRGNSRFVHPFED--RPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPLA 293
+ R FV E R + E RLMGFP DF R + G +V P+
Sbjct: 329 SYHKIQRLTGTFVKDGETGLRLFSELELKRLMGFPVDFKVPVSRTQMYRQFGNSVAVPMI 388
Query: 294 KAIA 297
KA+A
Sbjct: 389 KAVA 392
>sp|P05102|MTH1_HAEHA MODIFICATION METHYLASE HHAI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HHAI) (M.HHAI) >gi|66469|pir||XYHIH1 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
HhaI - Haemophilus haemolyticus >gi|3660437|pdb|6MHT|A
Chain A, Ternary Structure Of Hhai Methyltransferase
With Adohcy And Dna Containing 4'-Thio-2'deoxycytidine
At The Target >gi|4139680|pdb|9MHT|A Chain A,
Cytosine-Specific Methyltransferase HhaiDNA COMPLEX
>gi|443019|pdb|1HMY| Hhai Dna
(Cytosine-C5-)-Methyltransferase (E.C.2.1.1.37) Complex
With S-Adenosyl-L-Methionine >gi|4558252|pdb|10MH|A
Chain A, Ternary Structure Of Hhai Methyltransferase
With Adohcy And Hemimethylated Dna Containing
5,6-Dihydro-5-Azacytosine At The Target
>gi|4699814|pdb|2HMY|B Chain B, Binary Complex Of Hhai
Methyltransferase With Adomet Formed In The Presence Of
A Short Nonpsecific Dna Oligonucleotide
>gi|1942415|pdb|4MHT|A Chain A, Ternary Structure Of
Hhai Methyltransferase With Native Dna And Adohcy
>gi|1942412|pdb|3MHT|A Chain A, Ternary Structure Of
Hhai Methyltransferase With Unmodified Dna And Adohcy
>gi|2392799|pdb|5MHT|A Chain A, Ternary Structure Of
Hhai Methyltransferase With Hemimethylated Dna And
Adohcy >gi|4139675|pdb|8MHT|A Chain A, Cytosine-Specific
Methyltransferase HhaiDNA COMPLEX >gi|1065144|pdb|1MHT|A
Chain A, Covalent Ternary Structure Of Hhai
Methyltransferase, Dna And S-Adenosyl-L-Homocysteine
>gi|4139672|pdb|7MHT|A Chain A, Cytosine-Specific
Methyltransferase HhaiDNA COMPLEX
>gi|148949|gb|AAA24989.1| (J02677) DNA methylase
[Haemophilus haemolyticus]
Length = 327
Score = 88.9 bits (217), Expect = 7e-17
Identities = 87/315 (27%), Positives = 134/315 (41%), Gaps = 54/315 (17%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
++ +DLFAG GGF L + G E V + E K + Y NF G K DI ++ I
Sbjct: 12 LRFIDLFAGLGGFRLALESCGAECVYSNEWDKYAQEVYEMNF-GEKPEG-DITQVNEKTI 69
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
D D++ G PC+ F+ + K + + D G L + R V KPKV MENV
Sbjct: 70 PDHDILCAGFPCQAFSI-------SGKQKGFEDSRGTLFFDIARIVREKKPKVVFMENVK 122
Query: 128 QI--------MELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI----SNLELKP 175
+E+ K E D Y + VLNALDYG PQ R R+++ ++L ++
Sbjct: 123 NFASHDNGNTLEVVKNTMNELD---YSFHAKVLNALDYGIPQKRERIYMICFRNDLNIQN 179
Query: 176 KKIKGPRKVWDALKN--IPIDAPNH------DFWSPPSKIARRIPRL-------RWGEGA 220
+ P ++ +K+ +P H D +I + P+ + G+G
Sbjct: 180 FQFPKPFELNTFVKDLLLPDSEVEHLVIDRKDLVMTNQEIEQTTPKTVRLGIVGKGGQGE 239
Query: 221 QRFGRFQNWIRLHPY-------KPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVF 273
+ + I L Y V G +R +HP RE AR+MG+PD +
Sbjct: 240 RIYSTRGIAITLSAYGGGIFAKTGGYLVNGKTRKLHP--------RECARVMGYPDSYKV 291
Query: 274 LGGRNVQFDSVGEAV 288
+ + G +V
Sbjct: 292 HPSTSQAYKQFGNSV 306
>sp|P13864|MTDM_MOUSE DNA (CYTOSINE-5)-METHYLTRANSFERASE (DNA METHYLTRANSFERASE) (DNA
METASE) (MCMT) (M.MMUI) >gi|1765919|emb|CAA32910.1|
(X14805) DNA methyltransferase 1 [Mus musculus]
Length = 1620
Score = 88.2 bits (215), Expect = 1e-16
Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G E + AIE + P A+ + N PG V +D +K+
Sbjct: 1141 KLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKL 1200
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E+ GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1201 VMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1255
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + + + + + GY F VL A YG Q RRR
Sbjct: 1256 SYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1315
Query: 166 VFI 168
I
Sbjct: 1316 AII 1318
>gb|AAC40061.1| (AF036007) DNA (cytosine-5)-methyltransferase [Mus musculus]
Length = 1502
Score = 88.2 bits (215), Expect = 1e-16
Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G E + AIE + P A+ + N PG V +D +K+
Sbjct: 1023 KLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKL 1082
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E+ GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1083 VMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1137
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + + + + + GY F VL A YG Q RRR
Sbjct: 1138 SYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1197
Query: 166 VFI 168
I
Sbjct: 1198 AII 1200
>gi|6753664 DNA methyltransferase (cytosine-5) [Mus musculus]
>gi|6625687|gb|AAF19352.1| (AF162282) DNA
methyltransferase [Mus musculus]
Length = 1620
Score = 88.2 bits (215), Expect = 1e-16
Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G E + AIE + P A+ + N PG V +D +K+
Sbjct: 1141 KLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKL 1200
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E+ GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1201 VMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1255
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + + + + + GY F VL A YG Q RRR
Sbjct: 1256 SYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1315
Query: 166 VFI 168
I
Sbjct: 1316 AII 1318
>gb|AAF60965.1| (AF175431) DNA methyltransferase [Mus musculus]
>gi|9719249|gb|AAF97695.1| (AF175432) DNA
(cytosine-5)-methyltransferase [Mus musculus]
Length = 1502
Score = 88.2 bits (215), Expect = 1e-16
Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G E + AIE + P A+ + N PG V +D +K+
Sbjct: 1023 KLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKL 1082
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E+ GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1083 VMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1137
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + + + + + GY F VL A YG Q RRR
Sbjct: 1138 SYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1197
Query: 166 VFI 168
I
Sbjct: 1198 AII 1200
>pir||JC5145 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - African clawed
frog >gi|1731732|dbj|BAA11458.1| (D78638) DNA
(cytosine-5-)-methyltransferase [Xenopus laevis]
Length = 1490
Score = 87.4 bits (213), Expect = 2e-16
Identities = 55/188 (29%), Positives = 89/188 (47%), Gaps = 26/188 (13%)
Query: 2 GEGNKRMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQDIK 60
G+ +++ LD+F+G GG S GF G E AIE ++P A+ + N PG V +D
Sbjct: 1008 GDKLPKLRTLDVFSGCGGLSEGFHQAGISETNWAIEMWEPAAQAFRLNNPGTTVFTEDCN 1067
Query: 61 VISP---------------DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRL 105
++ + GDV+++ GGPPC+ F+ +N R Y L
Sbjct: 1068 ILLKLVMSGEKTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSL 1122
Query: 106 VLEFVRFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAP 160
V+ ++ + + +PK F++ENV + +K + + + GY F VL A YG
Sbjct: 1123 VVSYLSYCDYYRPKYFLLENVRNFVSFKKSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVA 1182
Query: 161 QVRRRVFI 168
Q RRR +
Sbjct: 1183 QTRRRAIV 1190
>pir||JE0378 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - rat
>gi|4160670|dbj|BAA37118.1| (AB012214) DNA cytosine 5
methyltransferase [Rattus rattus]
Length = 1622
Score = 87.4 bits (213), Expect = 2e-16
Identities = 55/183 (30%), Positives = 90/183 (49%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG + GF G E + AIE ++P A+ + N PG V +D +K+
Sbjct: 1143 KLRTLDVFSGCGGLTEGFHQAGISETLWAIEMWEPAAQAFRLNNPGTTVFTEDCNVLLKL 1202
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E+ GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1203 VMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1257
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + + + + + GY F VL A YG Q RRR
Sbjct: 1258 SYCDYYRPRFFLLENVRNSVSFRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1317
Query: 166 VFI 168
I
Sbjct: 1318 AII 1320
>pir||JC4172 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - chicken
>gi|1109610|dbj|BAA07867.1| (D43920) DNA
(cytosine-5-)-methyltransferase [Gallus gallus]
>gi|1096715|prf||2112268A DNA methyltransferase [Gallus
gallus]
Length = 1537
Score = 87.0 bits (212), Expect = 3e-16
Identities = 54/183 (29%), Positives = 88/183 (47%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP- 64
+++ LD+F+G GG S GF G E + AIE ++P A+ + N PG V +D V+
Sbjct: 1053 KLRTLDVFSGCGGLSEGFHQAGVSETLWAIEMWEPAAQAFRLNNPGTTVFTEDCNVLLKL 1112
Query: 65 --------------DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1113 VMSGEKTNSLGQKLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1167
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + ++ + + + GY F VL A YG Q RRR
Sbjct: 1168 SYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1227
Query: 166 VFI 168
+
Sbjct: 1228 AIV 1230
>gb|AAF73200.1|AF152342_1 (AF152342) DNA-(cytosine-5)-methyltransferase [Xiphophorus maculatus
x Xiphophorus helleri]
Length = 1503
Score = 86.2 bits (210), Expect = 5e-16
Identities = 56/183 (30%), Positives = 86/183 (46%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP- 64
+ + LD+F+G GG S GF G E + AIE ++P A+ + N PG V +D V+
Sbjct: 1024 KYRTLDVFSGCGGLSEGFHQAGISETLWAIEMWEPAAQAFRLNNPGTTVFTEDCNVLLKL 1083
Query: 65 --------------DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ GDV+++ GGPPC+ F+ +N R Y LV+ ++
Sbjct: 1084 VMSGEKTNSLGQKLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSYL 1138
Query: 111 RFVERLKPKVFVMENVPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRR 165
+ + +PK F++ENV + + K + + GY F VL A YG Q RRR
Sbjct: 1139 SYCDYYRPKFFLLENVRNFVSFKNSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1198
Query: 166 VFI 168
I
Sbjct: 1199 AII 1201
>emb|CAA90563.1| (Z50183) DNA (cytosine-5-)-methyltransferase [Paracentrotus lividus]
Length = 1612
Score = 85.8 bits (209), Expect = 6e-16
Identities = 57/183 (31%), Positives = 88/183 (47%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
++K LD+FAG GG S GF G E AIE +P A+ Y N PG V + D +++
Sbjct: 1130 KLKCLDVFAGCGGLSEGFHQAGICESSWAIEKEEPAAQAYRLNNPGSTVFSDDCNELLRL 1189
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E GDV+++ GGPPC+ F+ +N R Y L+ ++
Sbjct: 1190 VMQGEKTSRTGQKLPQKGDVELLCGGPPCQGFSGMN-----RFNSREYSKFKNSLISSYL 1244
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + +K + + + GY F +L A YG PQ RRR
Sbjct: 1245 SYCDYYRPRFFLLENVRNFVSYKKNMVLKLALRCLIRMGYQCTFGILQAGQYGVPQTRRR 1304
Query: 166 VFI 168
I
Sbjct: 1305 AII 1307
>pir||JC5210 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - sea urchin
(Paracentrotus lividus)
Length = 1612
Score = 85.8 bits (209), Expect = 6e-16
Identities = 57/183 (31%), Positives = 88/183 (47%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
++K LD+FAG GG S GF G E AIE +P A+ Y N PG V + D +++
Sbjct: 1130 KLKCLDVFAGCGGLSEGFHQAGICESSWAIEKEEPAAQAYRLNNPGSTVFSDDCNELLRL 1189
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E GDV+++ GGPPC+ F+ +N R Y L+ ++
Sbjct: 1190 VMQGEKTSRTGQKLPQKGDVELLCGGPPCQGFSGMN-----RFNSREYSKFKNSLISSYL 1244
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + +K + + + GY F +L A YG PQ RRR
Sbjct: 1245 SYCDYYRPRFFLLENVRNFVSYKKNMVLKLALRCLIRMGYQCTFGILQAGQYGVPQTRRR 1304
Query: 166 VFI 168
I
Sbjct: 1305 AII 1307
>sp|P26358|MTDM_HUMAN DNA (CYTOSINE-5)-METHYLTRANSFERASE (DNA METHYLTRANSFERASE) (DNA
METASE) (MCMT) (M.HSAI) >gi|105852|pir||S22610 DNA
(cytosine-5-)-methyltransferase (EC 2.1.1.37) - human
Length = 1495
Score = 85.4 bits (208), Expect = 8e-16
Identities = 55/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G + + AIE + P A+ + N PG V +D +K+
Sbjct: 1017 KLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKL 1076
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1077 VMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1131
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + ++ + + + GY F VL A YG Q RRR
Sbjct: 1132 SYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1191
Query: 166 VFI 168
I
Sbjct: 1192 AII 1194
>gi|4503351 DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase 1; DNA
methyltransferase [Homo sapiens]
>gi|1632819|emb|CAA45219.1| (X63692) DNA
(cytosine-5-)-methyltransferase [Homo sapiens]
Length = 1616
Score = 85.4 bits (208), Expect = 8e-16
Identities = 55/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G + + AIE + P A+ + N PG V +D +K+
Sbjct: 1138 KLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKL 1197
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 1198 VMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 1252
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + ++ + + + GY F VL A YG Q RRR
Sbjct: 1253 SYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 1312
Query: 166 VFI 168
I
Sbjct: 1313 AII 1315
>gb|AAF23609.1| (AF180682) DNA (cytosine-5)-methyltransferase [Homo sapiens]
Length = 1280
Score = 85.4 bits (208), Expect = 8e-16
Identities = 55/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G + + AIE + P A+ + N PG V +D +K+
Sbjct: 802 KLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKL 861
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 862 VMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 916
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + ++ + + + GY F VL A YG Q RRR
Sbjct: 917 SYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 976
Query: 166 VFI 168
I
Sbjct: 977 AII 979
>gi|11424851 DNA (cytosine-5-)-methyltransferase 1 [Homo sapiens]
Length = 596
Score = 85.4 bits (208), Expect = 8e-16
Identities = 55/183 (30%), Positives = 89/183 (48%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQD----IKV 61
+++ LD+F+G GG S GF G + + AIE + P A+ + N PG V +D +K+
Sbjct: 118 KLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKL 177
Query: 62 ISPDEI-----------GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ E GDV+++ GGPPC+ F+ +N R Y LV+ F+
Sbjct: 178 VMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSFL 232
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + ++ + + + GY F VL A YG Q RRR
Sbjct: 233 SYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 292
Query: 166 VFI 168
I
Sbjct: 293 AII 295
>gb|AAC69603.1| (AF097875) DNA methyltransferase [Danio rerio]
Length = 700
Score = 84.3 bits (205), Expect = 2e-15
Identities = 54/183 (29%), Positives = 86/183 (46%), Gaps = 26/183 (14%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVGF-EIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISP- 64
+++ LD+F+G GG S GF G E AIE + P A+ + N PG V +D V+
Sbjct: 222 KLRTLDVFSGCGGLSEGFHQAGISETHWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKL 281
Query: 65 --------------DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFV 110
+ GDV+++ GGPPC+ F+ +N R Y LV+ ++
Sbjct: 282 VMSGEKTNSLGQKLPQKGDVEMLCGGPPCQGFSGMN-----RFNSRTYSKFKNSLVVSYL 336
Query: 111 RFVERLKPKVFVMENVPQIMELEKYLRKEFD-----KAGYDIYFNVLNALDYGAPQVRRR 165
+ + +P+ F++ENV + ++ + + + GY F VL A YG Q RRR
Sbjct: 337 SYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRR 396
Query: 166 VFI 168
I
Sbjct: 397 AII 399
>emb|CAC10091.1| (AL442164) related to cytosine C5-DNA methyltransferase [Neurospora
crassa]
Length = 845
Score = 84.3 bits (205), Expect = 2e-15
Identities = 79/314 (25%), Positives = 130/314 (41%), Gaps = 42/314 (13%)
Query: 12 DLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIK----VISPDEI 67
D FAGAGG S G G + ++N++ + + NF G DI +++ +
Sbjct: 288 DTFAGAGGASRGITDAGVHLEFCVDNWEHAVASLNANFQGQDTTTYDIDMHNFIVNKEIR 347
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV- 126
VD++ PPC+ ++ + R +N + L ++ +E+++P++F +E
Sbjct: 348 HRVDILHLSPPCQVWSPAHTRPGQNDERNL------AILFSCTHLIEKIRPRLFTVEQTF 401
Query: 127 ----PQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKPKKIKGPR 182
P++ + L F GY + + V+N YG PQ RRR+ + GP
Sbjct: 402 GILHPRLDNFFQSLVHGFTDHGYSVRWKVVNFSHYGLPQPRRRLIMIG--------AGPG 453
Query: 183 KVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHPY------- 235
+ K P +P H P AR+ L +G +R+ Q +++ P
Sbjct: 454 E-----KLPPFPSPTHGNGLKPVTTARQ--ALAAIDGRRRYPLHQPYLQPFPTRKAHWDG 506
Query: 236 -KPAP--TVRGNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPPPL 292
KP P G + H R T +E A L GFP F G N +G A PP
Sbjct: 507 DKPLPYTVTCGAAENYHWSGLRQFTPQEYALLQGFPMHHKFAG--NYIKKQIGNAFPPIF 564
Query: 293 AKAIANFIFDVLSK 306
K + + + L K
Sbjct: 565 VKLLYKHLVECLDK 578
>sp|P25267|MTG1_HERAU MODIFICATION METHYLASE HGIGI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
HGIGI) (M.HGIGI) >gi|94550|pir||S21955 site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
HgiGIM - Herpetosiphon aurantiacus (fragment)
>gi|43475|emb|CAA38947.1| (X55143) methyltransferase
[Herpetosiphon aurantiacus]
Length = 126
Score = 83.9 bits (204), Expect = 2e-15
Identities = 51/124 (41%), Positives = 74/124 (59%), Gaps = 15/124 (12%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNF--PGVKV-IAQDIKVISP 64
MK +DLFAG GG SLGF GFEIVAA++N++P TY NF P ++ +A+ + IS
Sbjct: 1 MKTIDLFAGCGGMSLGFMQAGFEIVAAVDNWRPAITTYQQNFIHPIHELDLAEVDEAISL 60
Query: 65 DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGR--LVLEFVRFVERLKPKVFV 122
+ ++IIGGPPC+ F++ R + +GR L L+FV+ V ++P +
Sbjct: 61 IKTYSPELIIGGPPCQDFSSAGKR----------DEGLGRANLTLDFVKIVLAIQPAWVI 110
Query: 123 MENV 126
MENV
Sbjct: 111 MENV 114
>sp|P50188|MTN1_NOCAE MODIFICATION METHYLASE NAEI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
NAEI) (M.NAEI) >gi|775103|gb|AAC43325.1| (U09581) NaeI
modification methyltransferase [Nocardia
aerocolonigenes]
Length = 413
Score = 82.3 bits (200), Expect = 7e-15
Identities = 88/330 (26%), Positives = 140/330 (41%), Gaps = 46/330 (13%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI---KVISP 64
++V+++ AGAGG +LG + GF A+E A T N VI D+ V++P
Sbjct: 4 LEVVEICAGAGGQALGLEKAGFSHRLAVELDVNAAATLRKNLKSDVVITGDVADPSVLNP 63
Query: 65 DEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVME 124
E V ++ GG PC PF+ +L D + L V + +KP+ ++E
Sbjct: 64 MEHLGVSLLAGGVPCPPFSIAG--------KQLGADDMRDLFAWAVELCDVMKPRALMLE 115
Query: 125 NV-----PQIMELEKYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELK----- 174
NV P+ +++ + GY + +L+A D+G PQ+R R + L+ K
Sbjct: 116 NVRGLSMPRFAGYRQHVLDRLNDMGYVAEWRLLHASDFGVPQLRPRFVLVALQNKFAPYF 175
Query: 175 --PKKIKGPRKVWDALKNIPIDAPNHDFWSPPSKIARR----IPRLRWG---EGAQRFG- 224
P+ V + LK D D W + A + P + G G G
Sbjct: 176 TWPEPTGAAPTVGETLK----DLMAADGWEGAEEWAAQANDIAPTIVGGSKKHGGADLGP 231
Query: 225 --RFQNWIRL----HPYKPAPTVRGNSRFVHPFEDRPLTVREQARLMGFPD-DFVFLGGR 277
+ W L AP G+ V P LT AR+ G+ D +++F G +
Sbjct: 232 TRAKRAWAELGVDAMGVADAPPQPGDKFKVGP----KLTCEMVARIQGWRDGEWIFEGRK 287
Query: 278 NVQFDSVGEAVPPPLAKAIANFIFDVLSKE 307
++ +G A PPP+A+AI I L+ E
Sbjct: 288 TSRYRQIGNAFPPPVAEAIGKRIRAALNME 317
>gb|AAG17898.1|AF297971_2 (AF297971) DNA cytosine methyltransferase M.NgoMIII [Neisseria
gonorrhoeae]
Length = 377
Score = 81.1 bits (197), Expect = 2e-14
Identities = 88/381 (23%), Positives = 138/381 (36%), Gaps = 90/381 (23%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPDEI 67
MK L++F+GAGG + G +L GF+ + IE K + NF V D+
Sbjct: 1 MKSLEIFSGAGGLAKGLELAGFQHASFIELNKDACNSLRSNFNPKLVYQGDVADFDLSSQ 60
Query: 68 GDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVP 127
++VI GGPPC+PF+ + ++ VR+VE +PK F+ ENV
Sbjct: 61 EGIEVIAGGPPCQPFSLGGKHLAHEDRRDMFPHA--------VRYVEYYRPKAFIFENVK 112
Query: 128 QIMELE-----KY--LRKEFDKAG--------------------------YDIYFNVLNA 154
++ +Y LR + G Y + + +LNA
Sbjct: 113 GLLRKSFADYFEYILLRLTYPNLGILQNEDWKGHLTRLKEIEFNLYKGIKYKVSYQLLNA 172
Query: 155 LDYGAPQVRRRVFISNLELK-------PKKIKGPRKV-WDAL------------------ 188
DYG PQ R RV I + PK+ ++ W+
Sbjct: 173 ADYGVPQKRERVVIVGIRADLDIDWKFPKRTHSEDRLNWEKYVTGEYWEKHNEPKRFNKD 232
Query: 189 ------KNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRFGRFQNWIRLHP-------Y 235
K I P W IP G +++ R++P
Sbjct: 233 IAEKLQKKYGIFEPEKKPWQTVRDTLSDIPH-PLGNHKITGHEYRDGARIYPGHTGSGID 291
Query: 236 KPAPTVRGNSRFVHPFED---------RPLTVREQARLMGFPDDFVFLGGRNVQFDSVGE 286
+P+ T++ V E+ R T E L FP++FV G +G
Sbjct: 292 EPSKTIKAGGHGVPGGENMIRYDDGTVRYFTSYEAKLLQTFPEEFVISGAWGEAMRQIGN 351
Query: 287 AVPPPLAKAIANFIFDVLSKE 307
AVP L++ + + VLS++
Sbjct: 352 AVPVKLSEILGKHLMGVLSEK 372
>gb|AAB95336.1| (AF039582) EaeI methyltransferase alpha subunit [Enterobacter
aerogenes]
Length = 309
Score = 81.1 bits (197), Expect = 2e-14
Identities = 54/168 (32%), Positives = 82/168 (48%), Gaps = 11/168 (6%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
K+ KV FAG GGF LG + G E+V E K K N+P V + DI ++ D
Sbjct: 7 KQYKVSSFFAGIGGFDLGLEKAGMEVVFQCEINKFCQKVLRKNWPNVP-LHTDITQLNAD 65
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
EI + V GG PC+ ++ N +++ L + + +E KP+ V+EN
Sbjct: 66 EIPESSVWCGGFPCQDVSSANQGKRKG-----LEGARSGLFYTYAKLIEERKPEWLVIEN 120
Query: 126 VPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
VP ++ K + + GY + + VL+A +G PQ RRRV+I
Sbjct: 121 VPGLLNSHNGQDFKVVIDTLVELGYGVSWRVLDAKYFGTPQRRRRVYI 168
>gb|AAC77904.1| (AF051563) LlaKR2I methylase enzyme [Lactococcus lactis]
>gi|8489198|gb|AAF75616.1|AF216814_7 (AF216814)
5-methylcytosine methyltransferase [Lactococcus lactis
bv. diacetylactis]
Length = 420
Score = 81.1 bits (197), Expect = 2e-14
Identities = 53/178 (29%), Positives = 86/178 (47%), Gaps = 22/178 (12%)
Query: 8 MKVLDLFAGAGGFSLGFKLVGFEIVAA--IENFKPKAKT------YSHNFPGVKVIAQDI 59
MKVL+LFAG GGF +G + + ++P K+ Y ++FP + I I
Sbjct: 1 MKVLELFAGVGGFRIGLENADKNLFKTKWSNQWEPSRKSQDAFEVYDYHFPNSENINISI 60
Query: 60 KVISPDEIG--DVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLK 117
I ++ D D+I+GG PC+ ++ ++ E + G L E +R +K
Sbjct: 61 SDIPDEKFAEMDADIIVGGFPCQDYSVARSKKNEQGIE----GKKGVLFWEIIRATRIIK 116
Query: 118 PKVFVMENVPQIMELEKYLR--------KEFDKAGYDIYFNVLNALDYGAPQVRRRVF 167
PK ++ENV ++++ R F+ GY + + V+NA +YG Q RRRVF
Sbjct: 117 PKYLILENVDRLLKAPSKQRGRDFAIMLTSFNNLGYSVEWRVINAAEYGRSQRRRRVF 174
>pir||A81952 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) NMA1035 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|6900408|emb|CAB72018.1|
(AJ391258) putative cytosine-specific methyltransferase
[Neisseria meningitidis] >gi|7379737|emb|CAB84304.1|
(AL162754) putative modification methylase [Neisseria
meningitidis Z2491]
Length = 411
Score = 80.0 bits (194), Expect = 3e-14
Identities = 38/111 (34%), Positives = 60/111 (53%), Gaps = 12/111 (10%)
Query: 70 VDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQI 129
VD+++GG PC+ F+ + R D G L EF R V+ ++PK+F+ ENV +
Sbjct: 104 VDILVGGSPCQAFSMVGKRAG-------LEDTRGTLFYEFARVVDEVQPKIFIYENVKGL 156
Query: 130 MELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKP 175
+ + K ++ F GYD+YF ++N+ DYG PQ R R+F+ P
Sbjct: 157 LNHDNGKTWKVVKSVFYSLGYDLYFQIMNSKDYGIPQHRERIFVVGFHTPP 207
>pir||A81155 C-5 cytosine-specific DNA methylase NMB0826 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226061|gb|AAF41239.1| (AE002435) C-5
cytosine-specific DNA methylase [Neisseria meningitidis
MC58]
Length = 411
Score = 80.0 bits (194), Expect = 3e-14
Identities = 38/111 (34%), Positives = 60/111 (53%), Gaps = 12/111 (10%)
Query: 70 VDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQI 129
VD+++GG PC+ F+ + R D G L EF R V+ ++PK+F+ ENV +
Sbjct: 104 VDILVGGSPCQAFSMVGKRAG-------LEDTRGTLFYEFARVVDEVQPKIFIYENVKGL 156
Query: 130 MELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKP 175
+ + K ++ F GYD+YF ++N+ DYG PQ R R+F+ P
Sbjct: 157 LNHDNGKTWKVVKSVFYSLGYDLYFQIMNSKDYGIPQHRERIFVVGFHTPP 207
>gb|AAD32180.1|AF125564_2 (AF125564) putative site specific DNA methyltransferase [Neisseria
meningitidis]
Length = 411
Score = 79.2 bits (192), Expect = 6e-14
Identities = 38/111 (34%), Positives = 60/111 (53%), Gaps = 12/111 (10%)
Query: 70 VDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENVPQI 129
VD+++GG PC+ F+ + R D G L EF R V+ ++PK+F+ ENV +
Sbjct: 104 VDILVGGSPCQAFSMVGKRAG-------LEDTRGTLFYEFSRVVDEVQPKIFIYENVKGL 156
Query: 130 MELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISNLELKP 175
+ + K ++ F GYD+YF ++N+ DYG PQ R R+F+ P
Sbjct: 157 LNHDNGKTWKVVKSVFYSLGYDLYFQIMNSKDYGIPQHRERIFVVGFHTPP 207
>sp|P11408|MTM1_MORSP MODIFICATION METHYLASE MSPI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
MSPI) (M.MSPI) >gi|66474|pir||CTKEMM site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
MspI - Moraxella sp >gi|44539|emb|CAA32393.1| (X14191)
MspI methylase (AA 1-418) [Moraxella sp.]
Length = 418
Score = 76.9 bits (186), Expect = 3e-13
Identities = 87/310 (28%), Positives = 133/310 (42%), Gaps = 36/310 (11%)
Query: 9 KVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAK-TYSHNFPGVKVIAQDIKVISPDEI 67
K +DLF+G GG F++ G + V + E P AK TY NF GV V DI + I
Sbjct: 106 KFIDLFSGIGGIRQSFEVNGGKCVFSSE-IDPFAKFTYYTNF-GV-VPFGDITKVEATTI 162
Query: 68 GDVDVIIGGPPCEPFTAINPRRK-ENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMENV 126
D++ G PC+PF+ I R E+P G + E VR +E K V +ENV
Sbjct: 163 PQHDILCAGFPCQPFSHIGKREGFEHPTQ-------GTMFHEIVRIIETKKTPVLFLENV 215
Query: 127 PQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI---SNLELKPKKI 178
P ++ + K + + + GY ++ VL+A +G PQ R+R ++ N + +
Sbjct: 216 PGLINHDDGNTLKVIIETLEDMGYKVHHTVLDASHFGIPQKRKRFYLVAFLNQNIHFEFP 275
Query: 179 KGPRKVWDALKNIPIDAPNHDFWSPPSKIARRIPRLRWGEGAQRF------GRFQNWIRL 232
K P D + + D + S+ ++ + +G G + +
Sbjct: 276 KPPMISKDIGEVLESDVTGYSI----SEHLQKSYLFKKDDGKPSLIDKNTTGAVKTLV-- 329
Query: 233 HPYKPAPTVRGNSRFVHPFED--RPLTVREQARLMGFPDDFVFLGGRNVQFDSVGEAVPP 290
Y + G FV E R LT E +MGFP DFV R + +G +V
Sbjct: 330 STYHKIQRLTGT--FVKDGETGIRLLTTNECKAIMGFPKDFVIPVSRTQMYRQMGNSVVV 387
Query: 291 PLAKAIANFI 300
P+ IA I
Sbjct: 388 PVVTKIAEQI 397
>emb|CAB09661.1| (Z96933) DNA-C5-methyltransferase [Ascobolus immersus]
Length = 1336
Score = 76.9 bits (186), Expect = 3e-13
Identities = 73/286 (25%), Positives = 114/286 (39%), Gaps = 61/286 (21%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVG-FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVI-- 62
K++K LD+FAG GG +LG L G + AIE A T + NFP +V Q V+
Sbjct: 782 KKLKGLDIFAGCGGLTLGLDLSGAVDTKWAIEFAPSAANTLALNFPDAQVFNQCANVLLS 841
Query: 63 ----SPDE-------------------IGDVDVIIGGPPCEPFTAINPRRKENPKDRLYR 99
S DE G+VD I GGPPC+ F+ +N +K N
Sbjct: 842 RAIQSEDEGSLDIEYDLQGRVLPDLPKKGEVDFIYGGPPCQGFSGVNRYKKGN------- 894
Query: 100 DPIGRLVLEFVRFVERLKPKVFVMENVPQIMELE--------------------KYLRKE 139
D LV F+ +V+ KP+ ++ENV ++ + K++ +
Sbjct: 895 DIKNSLVATFLSYVDHYKPRFVLLENVKGLITTKLGNSKNAEGKWEGGISNGVVKFIYRT 954
Query: 140 FDKAGYDIYFNVLNALDYGAPQVRRRVFI--SNLELKPKKIKGPRKVWDALKNIPIDAPN 197
Y ++ + +YG PQ R RV + + + + P ++ L + P+
Sbjct: 955 LISMNYQCRIGLVQSGEYGVPQSRPRVIFLAARMGERLPDLPEPMHAFEVLDS-QYALPH 1013
Query: 198 HDFWSPPSKIARRIPRLRWGEGAQRFGRFQN-----WIRLHPYKPA 238
+ +PR+ GE +FQ W R PY A
Sbjct: 1014 IKRYHTTQNGVAPLPRITIGEAVSDLPKFQYANPGVWPRHDPYSSA 1059
>pir||I41075 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) EcoHK31I alpha chain - Escherichia coli
Length = 309
Score = 76.5 bits (185), Expect = 4e-13
Identities = 52/168 (30%), Positives = 82/168 (47%), Gaps = 11/168 (6%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
K+ KV FAG GGF LG + G E+V E K K N+ V + DI ++ D
Sbjct: 7 KQYKVSSFFAGIGGFDLGLEKAGMEVVFQCEINKFCQKVLRKNWSKVP-LHTDITRLNAD 65
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
EI + +V GG PC+ ++ N +++ L + + +E KP+ ++EN
Sbjct: 66 EIPESNVWCGGFPCQDVSSANQGKRKG-----LEGARSGLFYTYAKLIEERKPEWLIIEN 120
Query: 126 VPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
VP ++ K + + GY + + VL+A +G PQ RRRV+I
Sbjct: 121 VPGLLNSHNGQDFKVVIDTLVEFGYGVSWRVLDAKYFGTPQRRRRVYI 168
>emb|CAA57706.1| (X82231) M.EcoHK31I alpha polypeptide [Escherichia coli]
Length = 309
Score = 76.5 bits (185), Expect = 4e-13
Identities = 52/168 (30%), Positives = 82/168 (47%), Gaps = 11/168 (6%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDIKVISPD 65
K+ KV FAG GGF LG + G E+V E K K N+ V + DI ++ D
Sbjct: 7 KQYKVSSFFAGIGGFDLGLEKAGMEVVFQCEINKFCQKVLRKNWSKVP-LHTDITRLNAD 65
Query: 66 EIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFVMEN 125
EI + +V GG PC+ ++ N +++ L + + +E KP+ ++EN
Sbjct: 66 EIPESNVWCGGFPCQDVSSANQGKRKG-----LEGARSGLFYTYAKLIEERKPEWLIIEN 120
Query: 126 VPQIMELE-----KYLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
VP ++ K + + GY + + VL+A +G PQ RRRV+I
Sbjct: 121 VPGLLNSHNGQDFKVVIDTLVEFGYGVSWRVLDAKYFGTPQRRRRVYI 168
>sp|P00476|MTBS_BPSPR MODIFICATION METHYLASE SPRI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
SPRI) (M.SPRI) >gi|66465|pir||CTBPSR site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
- phage SPR >gi|224091|prf||1010250A methyltransferase
[Bacteriophage SPR]
Length = 439
Score = 74.9 bits (181), Expect = 1e-12
Identities = 59/235 (25%), Positives = 112/235 (47%), Gaps = 44/235 (18%)
Query: 7 RMKVLDLFAGAGGFS-------LGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI 59
+++V+ LF+G G F +G++LVGF + I+ + K+ HN ++ D+
Sbjct: 3 KLRVMSLFSGIGAFEAALRNIGVGYELVGF---SEIDKYAVKSFCAIHNVDE-QLNFGDV 58
Query: 60 KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
I ++ + D+++GG PC+ F+ R+ + D G L ++V ++ +PK
Sbjct: 59 SKIDKKKLPEFDLLVGGSPCQSFSVAGHRKG-------FEDTRGTLFFQYVETLKEKQPK 111
Query: 120 VFVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFIS----- 169
FV ENV ++ +K + + F + GY I +LN+ + PQ R R++I
Sbjct: 112 FFVFENVKGLINHDKGNTLNVMAEAFSEVGYRIDLELLNSKFFNVPQNRERLYIIGIRED 171
Query: 170 -------NLELKPKKI--KGPRKVWDALKNIPIDAPNHDF-WSPPSKIARRIPRL 214
+L+ K K I KG +++ + +D + +F W+ S +R+ L
Sbjct: 172 LIKNEEWSLDFKRKDILQKGKQRL------VELDIKSFNFRWTAQSAATKRLKDL 220
>pir||S02599 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) - phage SPR
Length = 406
Score = 74.9 bits (181), Expect = 1e-12
Identities = 59/235 (25%), Positives = 112/235 (47%), Gaps = 44/235 (18%)
Query: 7 RMKVLDLFAGAGGFS-------LGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI 59
+++V+ LF+G G F +G++LVGF + I+ + K+ HN ++ D+
Sbjct: 3 KLRVMSLFSGIGAFEAALRNIGVGYELVGF---SEIDKYAVKSFCAIHNVDE-QLNFGDV 58
Query: 60 KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
I ++ + D+++GG PC+ F+ R+ + D G L ++V ++ +PK
Sbjct: 59 SKIDKKKLPEFDLLVGGSPCQSFSVAGHRKG-------FEDTRGTLFFQYVETLKEKQPK 111
Query: 120 VFVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFIS----- 169
FV ENV ++ +K + + F + GY I +LN+ + PQ R R++I
Sbjct: 112 FFVFENVKGLINHDKGNTLNVMAEAFSEVGYRIDLELLNSKFFNVPQNRERLYIIGIRED 171
Query: 170 -------NLELKPKKI--KGPRKVWDALKNIPIDAPNHDF-WSPPSKIARRIPRL 214
+L+ K K I KG +++ + +D + +F W+ S +R+ L
Sbjct: 172 LIKNEEWSLDFKRKDILQKGKQRL------VELDIKSFNFRWTAQSAATKRLKDL 220
>gb|AAA32604.1| (K02124) DNA methyltransferase (Mtase; ttg start) [Bacteriophage
SPR] >gi|579089|emb|CAA25829.1| (X01670)
DNA-methyltransferase (aa 1-439) [Bacteriophage SPR]
Length = 439
Score = 74.9 bits (181), Expect = 1e-12
Identities = 59/235 (25%), Positives = 112/235 (47%), Gaps = 44/235 (18%)
Query: 7 RMKVLDLFAGAGGFS-------LGFKLVGFEIVAAIENFKPKAKTYSHNFPGVKVIAQDI 59
+++V+ LF+G G F +G++LVGF + I+ + K+ HN ++ D+
Sbjct: 3 KLRVMSLFSGIGAFEAALRNIGVGYELVGF---SEIDKYAVKSFCAIHNVDE-QLNFGDV 58
Query: 60 KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
I ++ + D+++GG PC+ F+ R+ + D G L ++V ++ +PK
Sbjct: 59 SKIDKKKLPEFDLLVGGSPCQSFSVAGHRKG-------FEDTRGTLFFQYVETLKEKQPK 111
Query: 120 VFVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFIS----- 169
FV ENV ++ +K + + F + GY I +LN+ + PQ R R++I
Sbjct: 112 FFVFENVKGLINHDKGNTLNVMAEAFSEVGYRIDLELLNSKFFNVPQNRERLYIIGIRED 171
Query: 170 -------NLELKPKKI--KGPRKVWDALKNIPIDAPNHDF-WSPPSKIARRIPRL 214
+L+ K K I KG +++ + +D + +F W+ S +R+ L
Sbjct: 172 LIKNEEWSLDFKRKDILQKGKQRL------VELDIKSFNFRWTAQSAATKRLKDL 220
>pir||T09107 DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) - fungus
(Ascobolus immersus) >gi|2906004|gb|AAC03766.1|
(AF030976) C5-DNA-methyltransferase; Masc2 [Ascobolus
immersus]
Length = 1356
Score = 74.9 bits (181), Expect = 1e-12
Identities = 72/286 (25%), Positives = 112/286 (38%), Gaps = 61/286 (21%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIENFKPKA-KTYSHNFPGVKVIAQDIKVI-- 62
K++K LD+FAG GG +LG L G F P A T + NFP +V Q V+
Sbjct: 782 KKLKGLDIFAGCGGLTLGLDLSGAVDTKWDIEFAPSAANTLALNFPDAQVFNQCANVLLS 841
Query: 63 ----SPDE-------------------IGDVDVIIGGPPCEPFTAINPRRKENPKDRLYR 99
S DE G+VD I GGPPC+ F+ +N +K N
Sbjct: 842 RAIQSEDEGSLDIEYDLQGRVLPDLPKKGEVDFIYGGPPCQGFSGVNRYKKGN------- 894
Query: 100 DPIGRLVLEFVRFVERLKPKVFVMENVPQIMELE--------------------KYLRKE 139
D LV F+ +V+ KP+ ++ENV ++ + K++ +
Sbjct: 895 DIKNSLVATFLSYVDHYKPRFVLLENVKGLITTKLGNSKNAEGKWEGGISNGVVKFIYRT 954
Query: 140 FDKAGYDIYFNVLNALDYGAPQVRRRVFI--SNLELKPKKIKGPRKVWDALKNIPIDAPN 197
Y ++ + +YG PQ R RV + + + + P ++ L + P+
Sbjct: 955 LISMNYQCRIGLVQSGEYGVPQSRPRVIFLAARMGERLPDLPEPMHAFEVLDS-QYALPH 1013
Query: 198 HDFWSPPSKIARRIPRLRWGEGAQRFGRFQN-----WIRLHPYKPA 238
+ +PR+ GE +FQ W R PY A
Sbjct: 1014 IKRYHTTQNGVAPLPRITIGEAVSDLPKFQYANPGVWPRHDPYSSA 1059
>sp|P16668|MTS3_STAAU MODIFICATION METHYLASE SAU3AI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
SAU3AI) (M.SAU3AI) >gi|97833|pir||JQ0760
methyltransferase (EC 2.1.1.-) - Staphylococcus aureus
>gi|153100|gb|AAA26673.1| (M32470) Sau3AIM protein
[Staphylococcus aureus]
Length = 412
Score = 74.5 bits (180), Expect = 2e-12
Identities = 52/180 (28%), Positives = 88/180 (48%), Gaps = 22/180 (12%)
Query: 7 RMKVLDLFAGAGGFSLGFKLV--GFEIVAAIENFKPKAKT------YSHNFPGVKVIAQD 58
++KV++LFAG GGF LG + G + ++P K YS F +D
Sbjct: 3 KIKVVELFAGVGGFRLGLENTKNGIFDITWANQWEPSRKIQHAFDCYSKRFKNGIHSNKD 62
Query: 59 IKVISPDEIG--DVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERL 116
I +S +E+ + D+I+GG PC+ ++ E + G L + +R+++
Sbjct: 63 IAQVSDEEMANTEADMIVGGFPCQDYSVARSLNGELG----IQGKKGVLFWQIIRYIQNT 118
Query: 117 KPKVFVMENVPQIMELEKYLR--------KEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
PK ++ENV ++++ R ++ GY++ + V+NA DYG Q RRRVFI
Sbjct: 119 FPKYLLLENVDRLLKSPSSQRGRDFAVMLSTLNELGYNVEWRVINAADYGNAQRRRRVFI 178
>pir||G81130 modification methylase NlaIV NMB1033 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226272|gb|AAF41432.1| (AE002453) modification
methylase NlaIV [Neisseria meningitidis MC58]
Length = 423
Score = 73.4 bits (177), Expect = 3e-12
Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 27/189 (14%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIE-----NFKPKA-KTYSHNFPGVKVIAQDI 59
+++K +DLF+G G GF+ + A E KP A + N+P +V DI
Sbjct: 2 QQIKFIDLFSGMSGIRKGFEQACRKQSVACECVFTSEIKPAALEVLKQNYPD-EVPYGDI 60
Query: 60 KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
I +I D D+++ G PC+ F+ R + D G L + R ++ KPK
Sbjct: 61 TKIETGDIPDFDILLAGFPCQAFSFAGKRLG-------FEDTRGTLFFDVARILKAKKPK 113
Query: 120 VFVMENVPQIMELEK------------YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF 167
F++ENV ++ ++ + + + GY + + VLNA D+G PQ R+R++
Sbjct: 114 GFILENVEGLVTHDRKDPTQKIGRTLTVILETLETLGYYVSWKVLNAKDFGIPQNRKRIY 173
Query: 168 IS-NLELKP 175
++ +L+ KP
Sbjct: 174 LTGSLKSKP 182
>pir||D81836 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) NMA1453 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7380106|emb|CAB84689.1|
(AL162756) DNA modification methylase [Neisseria
meningitidis Z2491]
Length = 423
Score = 73.4 bits (177), Expect = 3e-12
Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 27/189 (14%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIE-----NFKPKA-KTYSHNFPGVKVIAQDI 59
+++K +DLF+G G GF+ + A E KP A + N+P +V DI
Sbjct: 2 QQIKFIDLFSGMSGIRKGFEQACRKQSVACECVFTSEIKPAALEVLKQNYPD-EVPYGDI 60
Query: 60 KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
I +I D D+++ G PC+ F+ R + D G L + R ++ KPK
Sbjct: 61 TKIETGDIPDFDILLAGFPCQAFSFAGKRLG-------FEDTRGTLFFDVARILKAKKPK 113
Query: 120 VFVMENVPQIMELEK------------YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF 167
F++ENV ++ ++ + + + GY + + VLNA D+G PQ R+R++
Sbjct: 114 GFILENVEGLVTHDRKDPTQKIGRTLTVILETLEALGYYVSWKVLNAKDFGIPQNRKRIY 173
Query: 168 IS-NLELKP 175
++ +L+ KP
Sbjct: 174 LTGSLKSKP 182
>pir||JQ1019 site-specific DNA-methyltransferase (cytosine-specific) (EC
2.1.1.73) - phage H2
Length = 503
Score = 73.0 bits (176), Expect = 4e-12
Identities = 46/171 (26%), Positives = 84/171 (48%), Gaps = 17/171 (9%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVG--FEIVAAIENFKPKAKTYS--HNFPGVKVIAQDIKVI 62
+++V+ LF+G G F + +G +E+V E K K+Y HN D+ I
Sbjct: 3 KLRVMSLFSGIGAFEAALRNIGVEYELVGFSEIDKYAIKSYCAIHNVDEQSNFG-DVSKI 61
Query: 63 SPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFV 122
++ + D+++GG PC+ F+ R+ + D G L +++ ++ KP+ FV
Sbjct: 62 DKKKLPEFDLLVGGSPCQSFSVRGYRKG-------FEDTRGTLFFQYIDTLKEKKPRYFV 114
Query: 123 MENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
ENV ++ +K + + F + GY I +LN+ + PQ R R++I
Sbjct: 115 FENVKGLINHDKGNTLNIMAESFSEVGYRIDLELLNSKFFNVPQNRERIYI 165
>gb|AAA69959.1| (M72412) 5C-DNA methyltransferase [Bacillus amyloliquefaciens phage
H2]
Length = 503
Score = 73.0 bits (176), Expect = 4e-12
Identities = 46/171 (26%), Positives = 84/171 (48%), Gaps = 17/171 (9%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVG--FEIVAAIENFKPKAKTYS--HNFPGVKVIAQDIKVI 62
+++V+ LF+G G F + +G +E+V E K K+Y HN D+ I
Sbjct: 3 KLRVMSLFSGIGAFEAALRNIGVEYELVGFSEIDKYAIKSYCAIHNVDEQSNFG-DVSKI 61
Query: 63 SPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFV 122
++ + D+++GG PC+ F+ R+ + D G L +++ ++ KP+ FV
Sbjct: 62 DKKKLPEFDLLVGGSPCQSFSVRGYRKG-------FEDTRGTLFFQYIDTLKEKKPRYFV 114
Query: 123 MENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
ENV ++ +K + + F + GY I +LN+ + PQ R R++I
Sbjct: 115 FENVKGLINHDKGNTLNIMAESFSEVGYRIDLELLNSKFFNVPQNRERIYI 165
>sp|P09915|MTBR_BPRH1 MODIFICATION METHYLASE RHO11SI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
RHO11SI) (BSU P11S) (M.RHO11SI) >gi|66466|pir||CTBPRH
site-specific DNA-methyltransferase (cytosine-specific)
(EC 2.1.1.73) - phage rho-11s >gi|579194|emb|CAA28869.1|
(X05242) methyltransferase (AA 1-503) [Bacteriophage
Rho11s]
Length = 503
Score = 72.2 bits (174), Expect = 8e-12
Identities = 45/171 (26%), Positives = 86/171 (49%), Gaps = 17/171 (9%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVG--FEIVAAIENFKPKAKTYS--HNFPGVKVIAQDIKVI 62
+++V+ LF+G G F + +G +E+V E K K+Y HN ++ D+ I
Sbjct: 3 KLRVMSLFSGIGAFEAALRNIGVEYELVGFSEIDKYAIKSYCAIHN-ADEQLNFGDVSKI 61
Query: 63 SPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKVFV 122
++ + D+++GG PC+ F+ R+ + D G L +++ ++ +P+ FV
Sbjct: 62 DKKKLPEFDLLVGGSPCQSFSVAGYRKG-------FEDTRGTLFFQYIDTLKEKQPRYFV 114
Query: 123 MENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFI 168
ENV ++ +K + + F + GY I +LN+ + PQ R R++I
Sbjct: 115 FENVKGLINHDKGNTLNIMAESFSEVGYRIDLELLNSKFFNVPQNRERIYI 165
>sp|P50182|MTN4_NEILA MODIFICATION METHYLASE NLAIV (CYTOSINE-SPECIFIC METHYLTRANSFERASE
NLAIV) (M.NLAIV) >gi|628596|pir||S43886 DNA
methyltransferase - Neisseria lactamica
>gi|476227|gb|AAA53237.1| (U06074) M.NlaIV [Neisseria
lactamica]
Length = 423
Score = 71.8 bits (173), Expect = 1e-11
Identities = 52/189 (27%), Positives = 92/189 (48%), Gaps = 27/189 (14%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIE-----NFKPKA-KTYSHNFPGVKVIAQDI 59
+++K +DLF+G G GF+ + A + KP A + N+P +V DI
Sbjct: 2 QQIKFIDLFSGMSGIRKGFEQACRKQSVACKCVFTSEIKPAALEVLKQNYPD-EVPYGDI 60
Query: 60 KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
I +I D D+++ G PC+ F+ R + D G L + R ++ KPK
Sbjct: 61 TKIETGDIPDFDILLAGFPCQAFSFAGKRLG-------FEDTRGTLFFDVARILKAKKPK 113
Query: 120 VFVMENVPQIMELEK------------YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF 167
F++ENV ++ ++ + + + GY + + VLNA D+G PQ R+R++
Sbjct: 114 GFILENVEGLVTHDRKDPTQKIGRTLTVILETLEALGYYVSWKVLNAKDFGIPQNRKRIY 173
Query: 168 IS-NLELKP 175
++ +L+ KP
Sbjct: 174 LTGSLKSKP 182
>gb|AAA86268.1| (U43735) M.NgoV DNA methylase [Neisseria gonorrhoeae]
Length = 423
Score = 71.8 bits (173), Expect = 1e-11
Identities = 52/189 (27%), Positives = 92/189 (48%), Gaps = 27/189 (14%)
Query: 6 KRMKVLDLFAGAGGFSLGFKLVGFEIVAAIE-----NFKPKA-KTYSHNFPGVKVIAQDI 59
+++K +DLF+G G GF+ + A E KP A + N+P +V DI
Sbjct: 2 QQIKFIDLFSGMSGIRKGFEQACRKQSVACECVFTSEIKPAALEVLKQNYPD-EVPYGDI 60
Query: 60 KVISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPK 119
I +I D D+++ G PC+ F+ R + D G L + R ++ KPK
Sbjct: 61 TKIETGDIPDFDILLAGFPCQAFSFAGKRLG-------FEDTRGTLFFDVARILKAKKPK 113
Query: 120 VFVMENVPQIMELEK------------YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVF 167
F++ENV ++ ++ + + + GY + + VLNA ++G PQ R+R++
Sbjct: 114 GFILENVEGLVTHDRKDSTQKIGRTLTVILETLEALGYYVSWKVLNAKEFGIPQNRKRIY 173
Query: 168 IS-NLELKP 175
++ +L+ KP
Sbjct: 174 LTGSLKSKP 182
>sp|P34883|MTAB_SYNP2 MODIFICATION METHYLASE AQUI BETA SUBUNIT (CYTOSINE-SPECIFIC
METHYLTRANSFERASE AQUI BETA SUBUNIT) (M.AQUI BETA
SUBUNIT) >gi|2126510|pir||I39660 modification methylase
AquI, beta protein - Synechococcus sp. (PCC 7002)
>gi|142181|gb|AAA22068.1| (M28051) M.AquI beta protein
[Synechococcus PCC7002]
Length = 139
Score = 69.9 bits (168), Expect = 4e-11
Identities = 51/134 (38%), Positives = 69/134 (51%), Gaps = 21/134 (15%)
Query: 188 LKNIPIDAPNHDFWSPPSKIARRIPRLRWG----EGAQRFGRFQNWIRLHPYKPAPTVR- 242
+KN+ I NH+ + +I +++ G E + FG + RL P +P+PTV
Sbjct: 3 IKNVHIK--NHEQTAHAPSTLEKIRKVKQGGKLSEQTKTFG--STYRRLDPNQPSPTVTR 58
Query: 243 -GNSRFVHPFEDRPLTVREQARLMGFPDDFVFLGGR-----------NVQFDSVGEAVPP 290
G F+HPFEDR LTVRE A L FP D+ F G R QF VG AVPP
Sbjct: 59 SGYRDFIHPFEDRMLTVRELACLQTFPLDWEFTGTRLDSYSSKRKVTMTQFGQVGNAVPP 118
Query: 291 PLAKAIANFIFDVL 304
LA+A+A + + L
Sbjct: 119 LLAEAVAKAVSEQL 132
>sp|P19888|MTBA_BACAR MODIFICATION METHYLASE BANI (CYTOSINE-SPECIFIC METHYLTRANSFERASE
BANI) (M.BANI) >gi|66476|pir||CTBSBA site-specific
DNA-methyltransferase (cytosine-specific) (EC 2.1.1.73)
BanI - Bacillus aneurinolyticus
>gi|216242|dbj|BAA00613.1| (D00704) BanI modification
methylase [Aneurinibacillus aneurinolyticus]
Length = 428
Score = 69.5 bits (167), Expect = 5e-11
Identities = 54/182 (29%), Positives = 89/182 (48%), Gaps = 23/182 (12%)
Query: 7 RMKVLDLFAGAGGFSLGFKLVG------FEIVAAIENFKPKAKTYSHNFPGVKVIAQDIK 60
++K +DLFAG GG +GF+ E V + E K +TY+ NF + DI
Sbjct: 2 KIKFVDLFAGIGGIRIGFERAAKRFELETECVLSSEIDKKACETYALNFK--EEPQGDIH 59
Query: 61 VISPDEIGDVDVIIGGPPCEPFTAINPRRKENPKDRLYRDPIGRLVLEFVRFVERLKPKV 120
I+ + D ++ G PC+PF+ K + + D G L E R + +PK
Sbjct: 60 EIT--SFPEFDFLLAGFPCQPFSYAG-------KQQGFGDTRGTLFFEVERVLRDNRPKA 110
Query: 121 FVMENVPQIMELEK-----YLRKEFDKAGYDIYFNVLNALDYGAPQVRRRVFISN-LELK 174
F++ENV ++ +K + + ++ GY + + +LN+ +G PQ R R++I L K
Sbjct: 111 FLLENVRGLVTHDKGRTLKTIISKLEELGYGVSYLLLNSSTFGVPQNRVRIYILGILGSK 170
Query: 175 PK 176
PK
Sbjct: 171 PK 172
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.324 0.145 0.446
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 129172505
Number of Sequences: 2977
Number of extensions: 5952646
Number of successful extensions: 11995
Number of sequences better than 1.0e-10: 127
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 11547
Number of HSP's gapped (non-prelim): 204
length of query: 309
length of database: 189,106,746
effective HSP length: 50
effective length of query: 259
effective length of database: 159,182,396
effective search space: 41228240564
effective search space used: 41228240564
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.9 bits)
S2: 165 (68.7 bits)