BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2329 (PAB2329) DE:MORPHINE 6-DEHYDROGENASE HOMOLOG
(279 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||F75188 morphine 6-dehydrogenase homolog PAB2329 - Pyrococcu... 571 e-162
pir||D71221 probable morphine 6-dehydrogenase - Pyrococcus horik... 477 e-134
gb|AAK43305.1| Oxidoreductase, aldo/keto reductase family [Sulfo... 270 1e-71
gb|AAK42889.1| Dehydrogenase [Sulfolobus solfataricus] 266 3e-70
pir||F72218 oxidoreductase, aldo/keto reductase family - Thermot... 253 2e-66
pir||C72498 probable stress protein APE1961 - Aeropyrum pernix (... 234 8e-61
emb|CAC11176.1| (AL445063) alcohol dehydrogenase related protein... 228 5e-59
emb|CAC11561.1| (AL445064) conserved hypothetical protein [Therm... 212 3e-54
gb|AAK42991.1| Oxidoreductase [Sulfolobus solfataricus] 200 1e-50
pir||A83546 probable oxidoreductase PA0804 [imported] - Pseudomo... 169 3e-41
pir||E64938 probable aldehyde reductase (EC 1.1.1.-) b1781 - Esc... 163 2e-39
dbj|BAA15578.1| (D90821) Morphine 6-dehydrogenase (EC 1.1.1.218)... 151 1e-35
pir||S75995 hypothetical protein - Synechocystis sp. (strain PCC... 146 3e-34
dbj|BAB05877.1| (AP001514) plant-metabolite dehydrogenase [Bacil... 139 3e-32
pir||C70040 plant-metabolite dehydrogenase homolog yvgN - Bacill... 137 2e-31
dbj|BAB17681.1| (AB034727) prostaglandin F synthase [Trypanosoma... 135 7e-31
dbj|BAB07568.1| (AP001520) plant-metabolite dehydrogenase [Bacil... 133 3e-30
pir||D69988 plant metabolite dehydrogenase homolog ytbE - Bacill... 132 6e-30
gb|AAD19420.1| (AF102543) morphine 6-dehydrogenase [Zymomonas mo... 131 1e-29
pir||G72546 probable K+ channel beta 1 subunit APE1659 - Aeropyr... 130 2e-29
pir||A72308 oxidoreductase, aldo/keto reductase family - Thermot... 129 4e-29
pir||A32950 probable aldehyde reductase (EC 1.1.1.-) - Leishmani... 127 1e-28
sp|P22045|P100_LEIMA PROBABLE REDUCTASE >gi|603456|gb|AAA57350.1... 127 2e-28
pir||A59021 aldehyde reductase (EC 1.1.1.21) [validated] - pig >... 125 7e-28
sp|P80874|GS69_BACSU GENERAL STRESS PROTEIN 69 (GSP69) >gi|74479... 124 1e-27
sp|P80276|ALDR_PIG ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE) 124 1e-27
pdb|1DLA|B Chain B, Aldose Reductase (E.C.1.1.1.21) >gi|515112|p... 124 1e-27
pdb|1AH0| Pig Aldose Reductase Complexed With Sorbinil 124 1e-27
pdb|1EKO|A Chain A, Pig Aldose Reductase Complexed With Idd384 I... 124 1e-27
gb|AAG19006.1| (AE005000) aldehyde reductase; YafB [Halobacteriu... 123 2e-27
pir||H83124 probable oxidoreductase PA4167 [imported] - Pseudomo... 121 8e-27
pir||T34993 probable oxidoreductase - Streptomyces coelicolor >g... 121 8e-27
pir||C83506 probable oxidoreductase PA1127 [imported] - Pseudomo... 120 2e-26
sp|P46336|IOLS_BACSU IOLS PROTEIN (VEGETATIVE PROTEIN 147) (VEG1... 119 3e-26
pir||E75296 aldo/keto reductase - Deinococcus radiodurans (strai... 119 4e-26
pir||A35452 aldehyde reductase (EC 1.1.1.21) - bovine 118 6e-26
gi|6978491 aldehyde reductase 1 (low Km aldose reductase) (5.8 k... 118 6e-26
sp|P16116|ALDR_BOVIN ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE) ... 118 6e-26
gb|AAB25333.1| (S54973) 20 alpha-hydroxysteroid dehydrogenase, 2... 118 6e-26
gb|AAF49912.1| (AE003541) CG10638 gene product [Drosophila melan... 118 6e-26
sp|P21300|ALD1_MOUSE ALDOSE REDUCTASE-RELATED PROTEIN 1 (AR) (AL... 118 1e-25
gb|AAC36465.1| (AF052577) aldo-keto reductase [Homo sapiens] 117 1e-25
gi|4757742 aldo-keto reductase family 1, member B11 (aldose redu... 117 1e-25
gb|AAC53199.1| (U81045) aldo-keto reductase [Cricetulus griseus] 117 1e-25
pdb|1C9W|A Chain A, Cho Reductase With Nadp+ 117 1e-25
gi|11419799 similar to aldo-keto reductase family 1, member B11 ... 117 1e-25
pir||H83328 probable oxidoreductase PA2535 [imported] - Pseudomo... 117 2e-25
gi|6753148 androgen regulated vas deferens protein [Mus musculus... 116 2e-25
sp|P77256|YDJG_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN ANSA-RND INT... 115 5e-25
gi|6679791 fibroblast growth factor regulated protein [Mus muscu... 115 8e-25
pdb|1FRB| Fr-1 ProteinNADPHZOPOLRESTAT COMPLEX 115 8e-25
emb|CAB92199.1| (AL356592) oxidoreductase. [Streptomyces coelico... 115 8e-25
gb|AAD56034.1|AF182168_1 (AF182168) aldose-reductase-like protei... 114 1e-24
gb|AAA30370.1| (M31463) aldose reductase (EC 1.1.1.21) [Bos taurus] 114 1e-24
gb|AAF57392.1| (AE003789) CG9436 gene product [Drosophila melano... 114 1e-24
pir||A64745 probable aldehyde reductase (EC 1.1.1.-) yafB - Esch... 113 2e-24
gi|4502049 aldo-keto reductase family 1, member B1 (aldose reduc... 113 2e-24
gb|AAA51714.1| (J05017) aldose reductase [Homo sapiens] 113 2e-24
pdb|2ACQ| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed ... 113 2e-24
pdb|1ABN| Aldose Reductase (E.C.1.1.1.21) Mutant With Cys 298 ... 113 2e-24
pdb|1AZ1| Alrestatin Bound To C298aW219Y MUTANT HUMAN ALDOSE R... 113 2e-24
gb|AAB41556.1| (U13925) chalcone reductase [Medicago sativa subs... 113 3e-24
pir||S48850 chalcone reductase (EC 1.-.-.-) - alfalfa >gi|563538... 113 3e-24
gb|AAC13358.1| (U89150) aldose reductase [Mus musculus] 112 4e-24
sp|P45376|ALDR_MOUSE ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE) ... 112 4e-24
sp|P26690|6DCS_SOYBN NAD(P)H DEPENDENT 6'-DEOXYCHALCONE SYNTHASE... 112 5e-24
sp|P15122|ALDR_RABIT ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE) ... 112 5e-24
pir||S48849 chalcone reductase (EC 1.-.-.-) - alfalfa >gi|563536... 112 5e-24
pir||S48851 chalcone reductase (EC 1.-.-.-) - alfalfa >gi|563540... 112 5e-24
sp|P30863|YAFB_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN ASPU-MLTD IN... 111 9e-24
pdb|2ACU| Aldose Reductase (E.C.1.1.1.21) Mutant With Tyr 48 R... 111 9e-24
gi|6753038 aldo-keto reductase family 1, member B1 (aldose reduc... 111 9e-24
gb|AAF47812.1| (AE003479) CG12766 gene product [Drosophila melan... 111 9e-24
gb|AAG09967.1|AF248037_2 (AF248037) aldose reductase [Streptococ... 111 9e-24
dbj|BAB09734.1| (AB015476) aldo/keto reductase-like protein [Ara... 111 1e-23
pir||A34406 aldehyde reductase (EC 1.1.1.21) - rabbit (fragment)... 110 2e-23
pir||S75444 hypothetical protein slr1503 - Synechocystis sp. (st... 110 2e-23
gb|AAB41555.1| (U13924) chalcone reductase [Medicago sativa subs... 109 3e-23
dbj|BAB12273.1| (AB047854) aldehyde reductase [Acinetobacter sp.... 109 3e-23
dbj|BAA12084.1| (D83718) polyketide reductase [Glycyrrhiza echin... 109 4e-23
pir||T38538 probable oxidoreductase - fission yeast (Schizosacch... 109 4e-23
emb|CAB41997.1| (AJ131966) 3-dehydroecdysone 3beta-reductase [Sp... 109 4e-23
gb|AAF50039.1| (AE003544) CG6084 gene product [Drosophila melano... 109 5e-23
prf||2008147C protein RAKd [Rattus norvegicus] 109 5e-23
sp|Q46857|YQHE_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN METC-SUFI IN... 109 5e-23
gi|7304879 aldo-keto reductase AKR1C13 [Mus musculus] >gi|640737... 108 6e-23
pir||B75341 probable oxidoreductase - Deinococcus radiodurans (s... 108 6e-23
pir||H72307 oxidoreductase, aldo/keto reductase family - Thermot... 108 1e-22
gb|AAF42808.1|AF177041_1 (AF177041) aldo-keto reductase a [Mus m... 108 1e-22
pir||T02543 aldehyde dehydrogenase homolog F13M22.27 - Arabidops... 107 1e-22
dbj|BAB04730.1| (AP001510) oxidoreductase [Bacillus halodurans] 107 1e-22
sp|Q50668|YM98_MYCTU HYPOTHETICAL 34.9 KDA PROTEIN RV2298 >gi|74... 107 2e-22
dbj|BAA13113.1| (D86558) polyketide reductase (GGPKR1) [Glycyrrh... 107 2e-22
dbj|BAA13114.1| (D86559) polyketide reductase (GGPKR2) [Glycyrrh... 107 2e-22
gi|7304877 aldo-keto reductase AKR1C12 [Mus musculus] >gi|640738... 107 2e-22
prf||2008147A protein RAKb [Rattus norvegicus] 106 3e-22
pir||T45928 reductase-like protein - Arabidopsis thaliana >gi|76... 105 5e-22
gb|AAK43116.1| Oxidoreductase [Sulfolobus solfataricus] 105 7e-22
pir||JQ2253 aldehyde reductase (EC 1.1.1.21), NADPH-dependent - ... 104 9e-22
gb|AAD22264.1|AF133841_1 (AF133841) aldose reductase ALDRXV4 [Xe... 104 9e-22
gb|AAG15839.2|AF055910_1 (AF055910) NADPH-dependent mannose 6-ph... 104 9e-22
emb|CAC17786.1| (AJ245805) rhoB-crystallin [Lepidodactylus lugub... 104 9e-22
sp|P52898|DDBX_BOVIN DIHYDRODIOL DEHYDROGENASE 3 (PROSTAGLANDIN ... 104 1e-21
gb|AAD32792.1|AC007661_29 (AC007661) putative alcohol dehydrogen... 104 1e-21
pir||H70671 probable oxidoreductase - Mycobacterium tuberculosis... 103 2e-21
gi|9256562 aldo-keto reductase [Mus musculus] >gi|1698718|gb|AAB... 103 2e-21
sp|P05980|PGFS_BOVIN PROSTAGLANDIN-F SYNTHASE 1 (PGF SYNTHASE 1)... 103 3e-21
sp|P52897|PGF2_BOVIN PROSTAGLANDIN-F SYNTHASE 2 (PGF SYNTHASE 2)... 103 3e-21
sp|P54569|YQKF_BACSU HYPOTHETICAL OXIDOREDUCTASE IN ANSR-BMRU IN... 103 3e-21
pir||B82645 phenylacetaldehyde dehydrogenase XF1729 [imported] -... 103 3e-21
emb|CAA88322.1| (Z48360) aldose reductase [Hordeum vulgare] 102 4e-21
gi|6322556 Yjr096wp [Saccharomyces cerevisiae] >gi|1176340|sp|P4... 102 4e-21
emb|CAA11226.1| (AJ223291) chalcone reductase [Sesbania rostrata] 102 4e-21
gb|AAD23674.1|AC006841_3 (AC006841) putative NADPH dependent man... 102 4e-21
sp|P23901|ALDR_HORVU ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE) ... 102 5e-21
emb|CAB72221.1| (AL138852) putative oxidoreductase [Streptomyces... 102 5e-21
dbj|BAA93569.1| (AB035926) aldose reductase [Escherichia coli O1... 102 5e-21
sp|Q02198|MORA_PSEPU MORPHINE 6-DEHYDROGENASE (NALOXONE REDUCTAS... 102 6e-21
gb|AAF54175.1| (AE003677) CG2767 gene product [Drosophila melano... 102 6e-21
gb|AAB53024.1| (U30873) OrfC [Bacillus subtilis] 101 8e-21
sp|P46905|YCCK_BACSU HYPOTHETICAL OXIDOREDUCTASE IN NATB-RAPJ IN... 101 8e-21
pir||T02542 aldehyde dehydrogenase homolog F13M22.26 - Arabidops... 101 1e-20
pir||S61421 aldose reductase homolog - wild oat >gi|1155213|gb|A... 101 1e-20
gb|AAD38635.1|AF145660_1 (AF145660) BcDNA.GH10614 [Drosophila me... 101 1e-20
pir||T12582 auxin-induced protein - common sunflower >gi|2606077... 100 2e-20
gb|AAK43154.1| Oxidoreductase [Sulfolobus solfataricus] 100 2e-20
dbj|BAA99542.1| (AB045829) 3alpha-hydroxysteroid dehydrogenase v... 100 2e-20
pir||T48732 2,5-diketo-D-gluconic acid reductase related protein... 100 3e-20
sp|Q09923|YAKC_SCHPO HYPOTHETICAL 37.7 KD PROTEIN C1F7.12 IN CHR... 99 4e-20
gb|AAD23673.1|AC006841_2 (AC006841) putative NADPH dependent man... 99 5e-20
pir||S30383 morphine 6-dehydrogenase (EC 1.1.1.218) - Pseudomona... 99 7e-20
sp|P51652|PE2R_RAT 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE (20-ALP... 99 7e-20
pir||S76143 probable aldehyde reductase (EC 1.1.1.-) - Synechocy... 99 7e-20
pir||B65088 hypothetical protein b3012 - Escherichia coli (strai... 98 9e-20
gb|AAB97617.1| (U83687) NADPH-dependent mannose 6-phosphate redu... 98 9e-20
pir||S72569 probable aldehyde reductase (EC 1.1.1.-) C35D10.6 - ... 98 2e-19
gb|AAD30468.1| (AF124929) putative aldo/keto reductase family 2 ... 98 2e-19
pir||JC2330 luteal 20-alpha-hydroxysteroid dehydrogenase (EC 1.1... 97 2e-19
gi|6324694 Similar to mammalian aldo/keto reductases; Gcy1p [Sac... 96 4e-19
emb|CAB61562.2| (AL133171) putative aldo/keto reductase [Strepto... 96 4e-19
pir||T39901 probable aldo-keto reductase - fission yeast (Schiz... 96 5e-19
dbj|BAB11959.1| (AB047396) glycerol dehydrogenase [Zygosaccharom... 96 5e-19
sp|P25906|YDBC_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN MAOC-ACPD IN... 96 6e-19
pir||T39169 probable oxidoreductase [imported] - fission yeast ... 95 1e-18
dbj|BAB11960.2| (AB047397) glycerol dehydrogenase [Zygosaccharom... 94 2e-18
gi|5174391 aldo-keto reductase family 1, member A1 (aldehyde red... 94 2e-18
sp|Q10494|YDG7_SCHPO PROBABLE OXIDOREDUCTASE C26F1.07 IN CHROMOS... 94 2e-18
pdb|2ALR| Aldehyde Reductase 94 2e-18
emb|CAB09639.1| (Z96801) putative oxidoreductase [Mycobacterium ... 94 2e-18
gb|AAB97005.1| (AF039182) unknown [Fragaria x ananassa] 94 2e-18
emb|CAB55656.1| (AL117385) putative oxidoreductase [Streptomyces... 94 2e-18
sp|P51635|ALDX_RAT ALCOHOL DEHYDROGENASE [NADP+] (ALDEHYDE REDUC... 92 5e-18
sp|P28475|S6PD_MALDO NADP-DEPENDENT D-SORBITOL-6-PHOSPHATE DEHYD... 91 2e-17
gi|10946870 aldehyde reductase [Mus musculus] >gi|7677318|gb|AAF... 91 2e-17
gi|5174695 aldo-keto reductase family 1, member D1; steroid-5-be... 90 2e-17
dbj|BAA82867.1| (AB023951) delta4-3-oxosteroid 5beta-reductase [... 90 2e-17
gb|AAF13739.1|AF108435_1 (AF108435) NADPH-dependent codeinone re... 90 2e-17
pir||H83427 probable oxidoreductase PA1739 [imported] - Pseudomo... 90 3e-17
sp|P50578|ALDX_PIG ALCOHOL DEHYDROGENASE [NADP+] (ALDEHYDE REDUC... 90 3e-17
pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holo... 90 3e-17
pir||T48188 aldose reductase-like protein - Arabidopsis thaliana... 89 6e-17
prf||1403439A aldehyde reductase [Homo sapiens] 89 8e-17
gb|AAD42404.1|AF157493_12 (AF157493) 2,5-diketo-D-gluconate redu... 88 1e-16
sp|P31210|3O5B_RAT 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (DELTA(4... 87 2e-16
gb|AAD31332.1|AC007354_5 (AC007354) Strong similarity to gb|X562... 87 2e-16
emb|CAC16987.1| (AL450350) putative oxidoreductase [Streptomyces... 87 2e-16
dbj|BAA12182.1| (D83992) probable reductase, most similar to pir... 87 3e-16
gb|AAF13738.1|AF108434_1 (AF108434) NADPH-dependent codeinone re... 87 3e-16
pir||T40048 probable oxidoreductase - fission yeast (Schizosacch... 86 5e-16
gb|AAF13737.1|AF108433_1 (AF108433) NADPH-dependent codeinone re... 86 5e-16
gb|AAF13736.1|AF108432_1 (AF108432) NADPH-dependent codeinone re... 85 7e-16
gb|AAB80621.1| (AC002376) Match to Arabidopsis ATHKCP (gb|L40948... 85 9e-16
gb|AAD09330.1| (AF020040) xylose reductase [Pichia guilliermondii] 85 9e-16
dbj|BAA19477.1| (AB002106) D-xylose reductase II,III [Candida tr... 85 1e-15
gb|AAA87294.1| (L40948) K+ channel protein [Arabidopsis thaliana] 84 2e-15
pir||A75289 probable potassium channel, beta subunit - Deinococc... 84 2e-15
sp|P78736|XYL1_PACTA NAD(P)H-DEPENDENT XYLOSE REDUCTASE (XR) >gi... 84 2e-15
pir||T07394 probable potassium channel beta chain KB1 - potato >... 83 3e-15
pir||T22567 hypothetical protein F53F1.3 - Caenorhabditis elegan... 83 3e-15
pir||A64669 probable aldo-keto reductase (EC 1.-.-.-) - Helicoba... 83 4e-15
pir||T27575 hypothetical protein ZC443.1 - Caenorhabditis elegan... 83 4e-15
gb|AAF54731.1| (AE003694) CG3397 gene product [Drosophila melano... 83 4e-15
gi|10954651 similar to ydbC gene in Escherichia coli [Agrobacter... 82 8e-15
emb|CAA12646.1| (AJ225806) potassium channel beta subunit [Egeri... 81 1e-14
pir||D82644 sugar-phosphate dehydrogenase XF1723 [imported] - Xy... 81 2e-14
gb|AAD39334.1|AC007258_23 (AC007258) Putative Aldo/keto reductas... 81 2e-14
gb|AAG19415.1| (AE005035) probable oxidoreductase; YajO2 [Haloba... 80 4e-14
pir||H72391 K+ channel, beta subunit - Thermotoga maritima (stra... 79 5e-14
gb|AAC25601.1| (AF074484) xylose reductase [Candida tenuis] 79 7e-14
gb|AAD41821.1|AF147704_1 (AF147704) NDP-hexose 2,3-enoyl reducta... 79 7e-14
pir||T35344 probable oxidoreductase - Streptomyces coelicolor >g... 78 9e-14
emb|CAB62709.1| (AL133423) putative aldo/keto reductase [Strepto... 78 9e-14
gb|AAF86345.1|AF278715_1 (AF278715) xylose reductase [Candida sh... 78 9e-14
pir||T44623 aldehyde reductase homolog [imported] - Butyrivibrio... 78 1e-13
gi|6320079 Ydl124wp [Saccharomyces cerevisiae] >gi|2131342|pir||... 76 3e-13
gb|AAK40755.1| Oxidoreductase [Sulfolobus solfataricus] 74 2e-12
emb|CAA98021.1| (Z73640) 4-Dihydromethyl-trisporate dehydrogenas... 74 2e-12
emb|CAB76977.1| (AL159178) putative oxidoreductase [Streptomyces... 74 2e-12
dbj|BAB11492.1| (AB015469) aldose reductase-like protein [Arabid... 73 5e-12
>pir||F75188 morphine 6-dehydrogenase homolog PAB2329 - Pyrococcus abyssi
(strain Orsay) >gi|5457466|emb|CAB48957.1| (AJ248283)
MORPHINE 6-DEHYDROGENASE HOMOLOG [Pyrococcus abyssi]
Length = 279
Score = 571 bits (1456), Expect = e-162
Identities = 279/279 (100%), Positives = 279/279 (100%)
Query: 1 MVWKMAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDT 60
MVWKMAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDT
Sbjct: 1 MVWKMAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDT 60
Query: 61 AEFYGAGHSEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGTYIDLYL 120
AEFYGAGHSEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGTYIDLYL
Sbjct: 61 AEFYGAGHSEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGTYIDLYL 120
Query: 121 LHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS 180
LHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS
Sbjct: 121 LHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS 180
Query: 181 LMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIW 240
LMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIW
Sbjct: 181 LMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIW 240
Query: 241 EENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKLCV 279
EENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKLCV
Sbjct: 241 EENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKLCV 279
>pir||D71221 probable morphine 6-dehydrogenase - Pyrococcus horikoshii
>gi|3256416|dbj|BAA29099.1| (AP000001) 273aa long
hypothetical morphine 6-dehydrogenase [Pyrococcus
horikoshii]
Length = 273
Score = 477 bits (1214), Expect = e-134
Identities = 226/269 (84%), Positives = 247/269 (91%)
Query: 10 DFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHS 69
D K IG D+VTAIGMGTWGIGG E PDYS+DRESIE LRYGLELGINLIDTAEFYGAGHS
Sbjct: 3 DVKLIGSDEVTAIGMGTWGIGGYEVPDYSRDRESIEVLRYGLELGINLIDTAEFYGAGHS 62
Query: 70 EELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGTYIDLYLLHWPGDTWK 129
EELVGKAIEGFNREEIFI+SKVWP+HFGYE AKKAA+ASAKRLGTYIDLYLLHWPGD+W
Sbjct: 63 EELVGKAIEGFNREEIFIISKVWPSHFGYEKAKKAAKASAKRLGTYIDLYLLHWPGDSWG 122
Query: 130 KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEET 189
KIEETLHALE+LVDEGLIRYIGVSNFDLELL+RSQEAMR+YEIV N+VKYS+ DR PE +
Sbjct: 123 KIEETLHALEDLVDEGLIRYIGVSNFDLELLKRSQEAMRRYEIVANEVKYSIRDRWPETS 182
Query: 190 GLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPK 249
GLLDYMKRE I L+AYTPLEKG LAR+ CL EIG+ YGKT+AQVALNYLIWE+NV+AIPK
Sbjct: 183 GLLDYMKREKIALIAYTPLEKGTLARDPCLTEIGRAYGKTAAQVALNYLIWEDNVIAIPK 242
Query: 250 ASNKDHIKENFGAMGWRLSREDRERAKLC 278
A KDH+ ENFGAMGWRLSREDRE+A+ C
Sbjct: 243 AGRKDHVDENFGAMGWRLSREDREKARRC 271
>gb|AAK43305.1| Oxidoreductase, aldo/keto reductase family [Sulfolobus
solfataricus]
Length = 265
Score = 270 bits (684), Expect = 1e-71
Identities = 136/264 (51%), Positives = 187/264 (70%), Gaps = 6/264 (2%)
Query: 13 RIGDDKVTAIGMGTWGIGGKEF-PDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEE 71
R+ + V+ IG GTW IGG + PDYSKD IE L+Y + GIN+IDTAE YG GHSEE
Sbjct: 2 RLCNKDVSQIGFGTWKIGGGYWNPDYSKDSHYIEILKYVISKGINVIDTAEMYGGGHSEE 61
Query: 72 LVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKK 130
LVGKAIE F+R++IFI++KVW H Y+ ++A+ S KRL YIDLYL+HWP +
Sbjct: 62 LVGKAIENFDRDKIFIITKVWSNHLKYDDLIRSAKNSLKRLNAKYIDLYLIHWPNSS-VP 120
Query: 131 IEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETG 190
+EE+L A+EELVD+G++ IGVSNFD++LL + +KYEI N+++Y++ +++ E+
Sbjct: 121 LEESLRAMEELVDQGIVNCIGVSNFDIKLLEETMSITKKYEITANEIEYNVENKSAEK-D 179
Query: 191 LLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKA 250
++ + +R I ++AY+PL +G NK L EIG++Y KTS QVALNYL+ + IPKA
Sbjct: 180 VIPFCERNNIKVIAYSPLARGNAKNNKILEEIGRKYNKTSVQVALNYLL--RRSIPIPKA 237
Query: 251 SNKDHIKENFGAMGWRLSREDRER 274
S+KDHI E GA+GW LS ED ER
Sbjct: 238 SSKDHIDEILGALGWNLSDEDYER 261
>gb|AAK42889.1| Dehydrogenase [Sulfolobus solfataricus]
Length = 292
Score = 266 bits (672), Expect = 3e-70
Identities = 137/266 (51%), Positives = 188/266 (70%), Gaps = 5/266 (1%)
Query: 8 VSDFKRIGDDKVTAIGMGTWGIGGKE-FPDYSKDRESIEALRYGLELGINLIDTAEFYGA 66
+ D K+ V+ + GTW IGG + + +D E + A+R +ELG+ +IDTAE YG
Sbjct: 1 MEDVKKFKYFTVSPLAFGTWRIGGGYWYSSHDRDNEWVGAIRRAIELGLRVIDTAEMYGN 60
Query: 67 GHSEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGTYIDLYLLHWPGD 126
GH+EELVG+AI+ F+REE+FIVSKVWP+H Y++ K+A+ S++RLGTYIDLYLLH P
Sbjct: 61 GHAEELVGEAIKEFSREELFIVSKVWPSHADYDNVIKSAKNSSRRLGTYIDLYLLHAPSR 120
Query: 127 TWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTP 186
I +T+ A E+LVD+G+IR+ G+SNFD++ + ++E + KYEIV Q YSL+ R+
Sbjct: 121 V--PICKTIRAFEKLVDDGVIRFFGLSNFDVDQIESARECVSKYEIVAIQNHYSLLSRSD 178
Query: 187 EETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALN-YLIWEENVV 245
E L Y ++ G+ MAYTPLE GILARN+ LA IGK+Y KT+ QVALN Y+ + +++
Sbjct: 179 ERRALA-YAEKNGLMYMAYTPLENGILARNEFLANIGKKYNKTATQVALNWYITGKNSLI 237
Query: 246 AIPKASNKDHIKENFGAMGWRLSRED 271
I KAS HI+EN GAMGWRLS ED
Sbjct: 238 PIVKASKIPHIEENAGAMGWRLSEED 263
>pir||F72218 oxidoreductase, aldo/keto reductase family - Thermotoga maritima
(strain MSB8) >gi|4982320|gb|AAD36808.1|AE001812_18
(AE001812) oxidoreductase, aldo/keto reductase family
[Thermotoga maritima]
Length = 274
Score = 253 bits (639), Expect = 2e-66
Identities = 131/268 (48%), Positives = 186/268 (68%), Gaps = 11/268 (4%)
Query: 11 FKRIG--DDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGH 68
+K +G +++ A+G+GTWGIGG E PDYS+D E +E L+ +++G IDTAE+YG GH
Sbjct: 3 YKELGRTGEEIPALGLGTWGIGGFETPDYSRDEEMVELLKTAIKMGYTHIDTAEYYGGGH 62
Query: 69 SEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDT 127
+EEL+GKAI+ F RE++FIVSKVWPTH + ++ + KRL T Y+DLYL+HWP
Sbjct: 63 TEELIGKAIKDFRREDLFIVSKVWPTHLRRDDLLRSLENTLKRLDTDYVDLYLIHWPNPE 122
Query: 128 WKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYE--IVVNQVKYSLMDRT 185
+EETL A+ E V +GLIRYIGVSNFD LL +EA+ K + IV +QVKY++ DR
Sbjct: 123 -IPLEETLSAMAEGVRQGLIRYIGVSNFDRRLL---EEAISKSQEPIVCDQVKYNIEDRD 178
Query: 186 PEETGLLDYMKREGITLMAYTPLEKGILAR--NKCLAEIGKRYGKTSAQVALNYLIWEEN 243
PE GLL++ ++ G+TL+AY+PL + +L+ + L EI K +G T Q+ L +L+ + N
Sbjct: 179 PERDGLLEFCQKNGVTLVAYSPLRRTLLSEKTKRTLEEIAKNHGATIYQIMLAWLLAKPN 238
Query: 244 VVAIPKASNKDHIKENFGAMGWRLSRED 271
VVAIPKA +H++EN A +LS E+
Sbjct: 239 VVAIPKAGRVEHLRENLKATEIKLSEEE 266
>pir||C72498 probable stress protein APE1961 - Aeropyrum pernix (strain K1)
>gi|5105659|dbj|BAA80971.1| (AP000063) 272aa long
hypothetical stress protein [Aeropyrum pernix]
Length = 272
Score = 234 bits (591), Expect = 8e-61
Identities = 126/269 (46%), Positives = 180/269 (66%), Gaps = 15/269 (5%)
Query: 9 SDFKRIGDDK--VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGA 66
+DFK IG K ++A+G+GTW I DYS ++E+ Y +E GIN IDTAE YGA
Sbjct: 9 NDFKPIGKTKERLSAVGLGTWAIR-----DYSS---ALESYVYAIERGINHIDTAEMYGA 60
Query: 67 GHSEELVGKAIEGFNREEIFIVSKVWPTHF-GYESAKKAARASAKRLG-TYIDLYLLHWP 124
G +E VGK + R+ +++V+K++P F + A KAARASA+R+G +Y+D+ L+HWP
Sbjct: 61 GEAERFVGKVLRSVGRDRVYVVTKLYPFRFRDPDEAVKAARASAERMGVSYVDIILIHWP 120
Query: 125 GDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDR 184
D I++ + +LE + + GL RYIGVSNF E L + A +K+EIVVNQVKYS++DR
Sbjct: 121 -DPQTPIKDQVKSLEAIAEAGLARYIGVSNFSKEQLEEALTATKKHEIVVNQVKYSVLDR 179
Query: 185 TPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENV 244
EE L+ + I L AY+PLE+G +A + LA+IG++YGKT QVALN+++ N
Sbjct: 180 RAEE--LIPLAVEKSILLEAYSPLERGHVAEVRLLAKIGRQYGKTPVQVALNFIVSRPNF 237
Query: 245 VAIPKASNKDHIKENFGAMGWRLSREDRE 273
+AIPKA ++H+ E G++GWRL ED E
Sbjct: 238 IAIPKAERREHVDEILGSLGWRLKPEDIE 266
>emb|CAC11176.1| (AL445063) alcohol dehydrogenase related protein [Thermoplasma
acidophilum]
Length = 284
Score = 228 bits (576), Expect = 5e-59
Identities = 116/259 (44%), Positives = 172/259 (65%), Gaps = 17/259 (6%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
KV+ IG+GTW + G E++ ++RY L+ G+N IDTAE YG +E++VG+AI
Sbjct: 15 KVSVIGVGTWSLEGSR-------SENVRSIRYALDHGVNFIDTAEMYG---TEDIVGEAI 64
Query: 78 EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLH 136
+G+ RE++FI +KVWPTHF Y K+ S K+LGT Y+DLY LHWP + I+ET+
Sbjct: 65 KGYRREDLFIATKVWPTHFAYHDVLKSCEESLKKLGTDYVDLYQLHWPNPS-VSIKETMS 123
Query: 137 ALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMK 196
A+E+LVDEG IRYIG+SNF ++ ++ + A+ KY IV NQ++Y++ R E+ G+ D+ +
Sbjct: 124 AMEKLVDEGRIRYIGISNFSVKEMKEAMSALAKYRIVSNQLEYNVATREIEDEGIYDFCR 183
Query: 197 REGITLMAYTPLEKGILARN----KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASN 252
+ G+ ++AY+PL G + N + L +IGK+YGK AQVALN++I + IPKAS
Sbjct: 184 KNGMAIIAYSPLSHGKIFGNEMILETLTDIGKKYGKRPAQVALNWII-RKGAFPIPKASK 242
Query: 253 KDHIKENFGAMGWRLSRED 271
H+ EN + + LS ED
Sbjct: 243 PIHMAENIESTDFTLSDED 261
>emb|CAC11561.1| (AL445064) conserved hypothetical protein [Thermoplasma
acidophilum]
Length = 295
Score = 212 bits (535), Expect = 3e-54
Identities = 127/273 (46%), Positives = 177/273 (64%), Gaps = 19/273 (6%)
Query: 10 DFKRIGD--DKVTAIGMGTWGIGG----KEFPDYSKDRESIEALRYGLELGINLIDTAEF 63
+F+ G +K++ IG+GT+ G F S I A+R +E G+ LIDTAE
Sbjct: 14 EFREFGKTGEKISKIGVGTYYDVGWMFLARFGRKSGSEMKIRAIRTAVENGVTLIDTAEV 73
Query: 64 YGAGHSEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLH 122
YG SE+LV +AIEG +RE +FI +KVW TH Y+SA KA + S KRL YIDLY +H
Sbjct: 74 YG---SEDLVARAIEGVDRESLFIATKVWITHLSYDSAIKACKRSLKRLNMKYIDLYQIH 130
Query: 123 WPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLM 182
+P IE TL A+E+LVD+GLIRYIGVSNF+L+ L+ + EAM+KYEIV NQV YSL
Sbjct: 131 FPSPIGD-IEGTLRAMEKLVDDGLIRYIGVSNFNLDQLKHAMEAMKKYEIVSNQVHYSLR 189
Query: 183 DRTPEETGLLDYMKREGITLMAYTPLEKGILARNKC-----LAEIGKRYGKTSA-QVALN 236
R P ET ++ + ++ G+ ++A+ PLE G L R++ L+++ KRY + A Q+AL+
Sbjct: 190 HRDP-ETDMIPFAEKNGMAILAWYPLEHGDLVRDEAYPTAFLSDLRKRYPEMRASQIALS 248
Query: 237 YLI-WEENVVAIPKASNKDHIKENFGAMGWRLS 268
YL+ NV IP+ASN DH+ EN ++ + LS
Sbjct: 249 YLMEANSNVFPIPRASNPDHVLENINSVKYHLS 281
>gb|AAK42991.1| Oxidoreductase [Sulfolobus solfataricus]
Length = 304
Score = 200 bits (504), Expect = 1e-50
Identities = 114/285 (40%), Positives = 169/285 (59%), Gaps = 31/285 (10%)
Query: 16 DDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
++K++ + +G+W G P + +I+A++ +ELGIN IDTAE YG G SE ++G+
Sbjct: 10 NEKISPLILGSWEFGT---PSIIDENNAIKAIQRAIELGINAIDTAESYGNGLSETIIGR 66
Query: 76 AIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEET 134
AI F RE++FI++KV H Y+ KA+ S KRL T YIDLYL+HWP + + I ET
Sbjct: 67 AISKFKREDLFIITKVSIDHLRYDDVLKASEGSLKRLNTSYIDLYLVHWP-NHYVPIRET 125
Query: 135 LHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDY 194
A+E L +EG IRY+G+SNF L L+R +E + K ++ N++ Y+++ R E+ +L Y
Sbjct: 126 AKAMERLFNEGKIRYVGLSNFSLPLMREFREHLSKTDVAANELHYNVLFRDVEKE-VLPY 184
Query: 195 MKREGITLMAYTPLEKG---------------ILARN----------KCLAEIGKRYGKT 229
M RE I L+AY L G +LAR + ++ I K GKT
Sbjct: 185 MLRENIPLLAYDALGLGYLIGRKEVRNEYRWYVLARETYIKNLEPLIEEISSIAKELGKT 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV LN+L+ ++NV AI + +DH+KEN G++GW L D R
Sbjct: 245 PAQVVLNWLVSKDNVFAIFNTTKEDHLKENLGSLGWSLRDSDLRR 289
>pir||A83546 probable oxidoreductase PA0804 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9946696|gb|AAG04193.1|AE004515_9
(AE004515) probable oxidoreductase [Pseudomonas
aeruginosa]
Length = 273
Score = 169 bits (424), Expect = 3e-41
Identities = 113/260 (43%), Positives = 149/260 (56%), Gaps = 15/260 (5%)
Query: 14 IGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELV 73
I +V AIG GTW IG + + + + ALR G+ELG+ LIDTAE Y G +E++V
Sbjct: 7 IDGQEVAAIGQGTWHIGEQP----GERKREVAALREGIELGMTLIDTAEMYAEGGAEDVV 62
Query: 74 GKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWPGDTWKKIE 132
G AI G REE+F+VSKV+P + E A S +RLG IDLYLLHW G +E
Sbjct: 63 GAAIAG-RREEVFLVSKVYPHNASREGLPAACERSLRRLGCETIDLYLLHWQGR--YPLE 119
Query: 133 ETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLL 192
ET+ A E L D+G I GVSNFDL + NQV Y+L +R E LL
Sbjct: 120 ETIEAFERLRDQGKILRWGVSNFDL----GDMYELDGSACAANQVMYNLEER-GIEYDLL 174
Query: 193 DYMKREGITLMAYTPL-EKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKAS 251
+ + G+ +MAY P+ + G L R+ L EI R+ +SAQVAL +L+ E+ V+AIPKA
Sbjct: 175 PWCQERGMPVMAYCPVGQGGRLLRHPALGEIAARHDASSAQVALAWLL-EQGVIAIPKAV 233
Query: 252 NKDHIKENFGAMGWRLSRED 271
HI+ N A LS +D
Sbjct: 234 TSAHIRLNAAAADLELSADD 253
>pir||E64938 probable aldehyde reductase (EC 1.1.1.-) b1781 - Escherichia coli
(strain K-12) >gi|1736409|dbj|BAA15582.1| (D90822)
Morphine 6-dehydrogenase (EC 1.1.1.218) (Naloxone
reductase). [Escherichia coli]
>gi|1788081|gb|AAC74851.1| (AE000273) putative an
aldehyde reductase [Escherichia coli K12]
Length = 284
Score = 163 bits (409), Expect = 2e-39
Identities = 102/260 (39%), Positives = 154/260 (59%), Gaps = 14/260 (5%)
Query: 15 GDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVG 74
GD + A+G GTW +G D S+ + + ALR G+ELG+ LIDTAE Y G +E++VG
Sbjct: 10 GDVSLPAVGQGTWYMG----EDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVG 65
Query: 75 KAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEE 133
+A+ G RE++F+VSKV+P + G + A A AS +RL T Y+DLYLLHW G EE
Sbjct: 66 EALTGL-REKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSF--AFEE 122
Query: 134 TLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLD 193
T+ A+E+L+ +G IR GVSN D ++ + + NQV Y L R E LL
Sbjct: 123 TVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSR-GIEYDLLP 181
Query: 194 YMKREGITLMAYTPLE-----KGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIP 248
+ +++ + +MAY+PL + L +N + EI + ++AQV L ++I + V+AIP
Sbjct: 182 WCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAIP 241
Query: 249 KASNKDHIKENFGAMGWRLS 268
KA+ H+++N + LS
Sbjct: 242 KAATIAHVQQNAAVLEVELS 261
>dbj|BAA15578.1| (D90821) Morphine 6-dehydrogenase (EC 1.1.1.218) (Naloxone
reductase). [Escherichia coli]
Length = 261
Score = 151 bits (377), Expect = 1e-35
Identities = 94/239 (39%), Positives = 143/239 (59%), Gaps = 10/239 (4%)
Query: 36 DYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEGFNREEIFIVSKVWPTH 95
D S+ + + ALR G+ELG+ LIDTAE Y G +E++VG+A+ G RE++F+VSKV+P +
Sbjct: 4 DASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGL-REKVFLVSKVYPWN 62
Query: 96 FGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSN 154
G + A A AS +RL T Y+DLYLLHW G EET+ A+E+L+ +G IR GVSN
Sbjct: 63 AGGQKAINACEASLRRLNTDYLDLYLLHWSGSF--AFEETVAAMEKLIAQGKIRRWGVSN 120
Query: 155 FDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLE----- 209
D ++ + + NQV Y L R E LL + +++ + +MAY+PL
Sbjct: 121 LDYADMQELWQLPGGNQCATNQVLYHLGSR-GIEYDLLPWCQQQQMPVMAYSPLAQAGRL 179
Query: 210 KGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLS 268
+ L +N + EI + ++AQV L ++I + V+AIPKA+ H+++N + LS
Sbjct: 180 RNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAIPKAATIAHVQQNAAVLEVELS 238
>pir||S75995 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1001355|dbj|BAA10842.1| (D64006) auxin-induced
protein [Synechocystis sp.]
Length = 314
Score = 146 bits (365), Expect = 3e-34
Identities = 95/297 (31%), Positives = 151/297 (49%), Gaps = 40/297 (13%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKD---RESIEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
+ +G+GTW G F Y KD +E A LE G+ LIDTAE YG G SE L+G+
Sbjct: 13 IAPLGLGTWSWGDTLFWAYGKDFGPQEVEGAFHASLEAGVTLIDTAEIYGFGESERLIGR 72
Query: 76 AIEGFNREEIFIVSKVWPTHFGYESAK--KAARASAKRLGT-YIDLYLLHWPGDTWKKIE 132
+++ I +K +P + ++ + KA AS +RL I LY +HWP + W K
Sbjct: 73 FCRE-KTQKVEIATKYFPLPWRWQRSDITKALTASLERLQMDTICLYQIHWPLEFWLKTP 131
Query: 133 ETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVV--NQVKYSLMDRTPEETG 190
+ + L V +G I+ +GVSN+ + + + E + I + NQV YSL++R E G
Sbjct: 132 DFMAVLAAEVKKGRIQAVGVSNYSAQQMAIAHECLAAQGIPLASNQVPYSLLNREIESNG 191
Query: 191 LLDYMKREGITLMAYTPLEKGILARN-------------------------------KCL 219
+L ++ +T++AY+PL +G+L L
Sbjct: 192 ILTQARQLNVTILAYSPLAQGLLTGKYRPENSPSLQGARRLDPRFSTKGLRKLAPLLTLL 251
Query: 220 AEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAK 276
+ ++ KT AQ+ALN+LI + NV+ IP A N ++N GA+GW+L+ E+ E+ +
Sbjct: 252 DTLADKHDKTPAQIALNWLIAQGNVIPIPGAKNASQAQQNAGALGWQLNPEEIEQLR 308
>dbj|BAB05877.1| (AP001514) plant-metabolite dehydrogenase [Bacillus halodurans]
Length = 276
Score = 139 bits (348), Expect = 3e-32
Identities = 96/240 (40%), Positives = 136/240 (56%), Gaps = 13/240 (5%)
Query: 38 SKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI--EGFNREEIFIVSKVWPTH 95
S+ E I++++ + G IDTA YG +EE VGKAI G REE+FI SKVW
Sbjct: 28 SEGDEVIQSVKDAIRAGYKSIDTAAVYG---NEEGVGKAIAESGVPREELFITSKVWNAD 84
Query: 96 FGYESAKKAARASAKRLG-TYIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSN 154
G++S A S K+LG Y+DLYL+HWP K ET ALE+L +GL+R IGVSN
Sbjct: 85 QGFDSTISAFNTSLKKLGLDYLDLYLVHWP--VKGKYVETWKALEKLYQDGLVRAIGVSN 142
Query: 155 FDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA 214
F + L+ EA +VNQV+Y +T L D+ K+ I L A++PL++G L
Sbjct: 143 FQVHHLKDVLEA-GSIVPMVNQVEY---HPHLTQTELHDFCKQNKIQLEAWSPLKQGQLL 198
Query: 215 RNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ + I + + KT AQ+ L + + E VV IPK+ KD I N ++L+ ED ++
Sbjct: 199 NDPTIVAIAEAHQKTPAQIILRWDLQNE-VVTIPKSVKKDRIISNADIFDFQLTEEDMQK 257
>pir||C70040 plant-metabolite dehydrogenase homolog yvgN - Bacillus subtilis
>gi|2635853|emb|CAB15345.1| (Z99121) alternate gene
name: yvsB~similar to plant-metabolite dehydrogenase
[Bacillus subtilis] >gi|2832788|emb|CAA11712.1|
(AJ223978) putative reductase protein, YvgN [Bacillus
subtilis]
Length = 276
Score = 137 bits (341), Expect = 2e-31
Identities = 95/238 (39%), Positives = 138/238 (57%), Gaps = 17/238 (7%)
Query: 42 ESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE--GFNREEIFIVSKVWPTHFGYE 99
E+ E+++ ++ G IDTA Y +EE VG I+ G REE+FI SKVW GYE
Sbjct: 32 EATESVKAAIKNGYRSIDTAAIY---KNEEGVGIGIKESGVAREELFITSKVWNEDQGYE 88
Query: 100 SAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLE 158
+ A S +RL Y+DLYL+HWPG K ++T ALE+L +G IR IGVSNF +
Sbjct: 89 TTLAAFEKSLERLQLDYLDLYLIHWPGKD--KYKDTWRALEKLYKDGKIRAIGVSNFQVH 146
Query: 159 LLRRSQEAMRKYEI--VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARN 216
L +E ++ EI +VNQV++ E L DY K +GI L A++PL +G L N
Sbjct: 147 HL---EELLKDAEIKPMVNQVEFHPRLTQKE---LRDYCKGQGIQLEAWSPLMQGQLLDN 200
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ L +I +++ K+ AQV L + + + VV IPK+ + I EN + LS+ED ++
Sbjct: 201 EVLTQIAEKHNKSVAQVILRWDL-QHGVVTIPKSIKEHRIIENADIFDFELSQEDMDK 257
>dbj|BAB17681.1| (AB034727) prostaglandin F synthase [Trypanosoma brucei]
Length = 276
Score = 135 bits (336), Expect = 7e-31
Identities = 98/279 (35%), Positives = 141/279 (50%), Gaps = 39/279 (13%)
Query: 5 MAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY 64
MA K + +G G W + E+ A + ++ G IDTA Y
Sbjct: 1 MALTQSLKLSNGVMMPVLGFGMWKL--------QDGNEAETATMWAIKSGYRHIDTAAIY 52
Query: 65 GAGHSEELVGKAIE--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLL 121
+EE G+AI G REE+F+ +K+W + GYES A S K+LG Y+DLYL+
Sbjct: 53 ---KNEESAGRAIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLI 109
Query: 122 HWPG-----DTWKKIEETLHALEELVDEGLIRYIGVSNFDL----ELLRRSQEAMRKYEI 172
HWPG DTWK A E+L + +R IGVSNF ELL+ + A
Sbjct: 110 HWPGKDKFIDTWK-------AFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAP----- 157
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQ 232
+VNQ++ + + L +Y K + I + A++PL +G L + L IG +YGKT+AQ
Sbjct: 158 MVNQIE---LHPLLNQKALCEYCKSKNIAVTAWSPLGQGHLVEDARLKAIGGKYGKTAAQ 214
Query: 233 VALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
V L + I + V+ IPK+ N+ IKEN + L+ ED
Sbjct: 215 VMLRWEI-QAGVITIPKSGNEARIKENGNIFDFELTAED 252
>dbj|BAB07568.1| (AP001520) plant-metabolite dehydrogenase [Bacillus halodurans]
Length = 278
Score = 133 bits (331), Expect = 3e-30
Identities = 93/240 (38%), Positives = 130/240 (53%), Gaps = 15/240 (6%)
Query: 38 SKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE--GFNREEIFIVSKVWPTH 95
++ E I A+R L+ G IDTA Y +E VG+AI G R+EIF+ +KVW T
Sbjct: 28 AEGEEVIGAVRAALKAGYRSIDTASLY---QNEVGVGQAIRESGIPRDEIFVTTKVWNTE 84
Query: 96 FGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSN 154
GY+ A S KRLG IDLYL+HWP +K +T ALE L E +R IGVSN
Sbjct: 85 QGYDETLAAFERSRKRLGLEVIDLYLIHWP--VREKFLDTWRALETLYKERKVRAIGVSN 142
Query: 155 FDLELLRRSQEAMRKYEIVVNQVKYS-LMDRTPEETGLLDYMKREGITLMAYTPLEKGIL 213
F++ L + +VNQV++ + + P LL + K I L A+ PL KG +
Sbjct: 143 FNIHHLETVMN-ISDINPMVNQVEFHPFLTQKP----LLTFCKAHDIQLEAWRPLTKGEI 197
Query: 214 ARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
+ + + K+YGKT AQ+ L + + E VV IPK+ ++ I+EN + LS ED E
Sbjct: 198 FTHPVVQALAKKYGKTPAQIVLRWNL-EHRVVTIPKSVREERIQENANIFDFHLSPEDVE 256
>pir||D69988 plant metabolite dehydrogenase homolog ytbE - Bacillus subtilis
>gi|2293328|gb|AAC00406.1| (AF008220) putative morphine
dehydrogenase [Bacillus subtilis]
>gi|2635370|emb|CAB14865.1| (Z99118) similar to plant
metabolite dehydrogenase [Bacillus subtilis]
Length = 280
Score = 132 bits (328), Expect = 6e-30
Identities = 87/242 (35%), Positives = 133/242 (54%), Gaps = 21/242 (8%)
Query: 42 ESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE------GFNREEIFIVSKVWPTH 95
E + A++ + G IDTA YG +E VG+ I G +RE++FI SKVW
Sbjct: 32 ELVNAVKTAIVHGYRSIDTAAIYG---NEAGVGEGIREGIEEAGISREDLFITSKVWNAD 88
Query: 96 FGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSN 154
GYE A S +LG Y+DLYL+HWP + K +E ALE L EG I+ IGVSN
Sbjct: 89 LGYEETLAAFETSLSKLGLDYLDLYLIHWPVEG--KYKEAWRALETLYKEGRIKAIGVSN 146
Query: 155 FDLELLRRSQEAMRKYEI--VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI 212
F + L ++ M EI ++NQV++ E L+ Y + +GI + A++PL +G
Sbjct: 147 FQIHHL---EDLMTAAEIKPMINQVEFHPRLTQKE---LIRYCQNQGIQMEAWSPLMQGQ 200
Query: 213 LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDR 272
L + LA+I + Y K+ AQ+ L + + + ++ IPK++ + IKEN + L+++D
Sbjct: 201 LLDHPVLADIAQTYNKSVAQIILRWDL-QHGIITIPKSTKEHRIKENASVFDFELTQDDM 259
Query: 273 ER 274
R
Sbjct: 260 NR 261
>gb|AAD19420.1| (AF102543) morphine 6-dehydrogenase [Zymomonas mobilis]
Length = 256
Score = 131 bits (325), Expect = 1e-29
Identities = 80/221 (36%), Positives = 126/221 (56%), Gaps = 6/221 (2%)
Query: 44 IEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKK 103
+ AL+ G+ LG+ LIDTAE YG G +E VG+ I+G RE +++VSK +P + ++ K
Sbjct: 13 VAALKEGIALGMTLIDTAEMYGEGAAEICVGEDIKGTPRESLYLVSKAYPQNASRKTLPK 72
Query: 104 AARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRR 162
AS KRLGT Y+DL G + ET+ +E L G IR GVSN D + +
Sbjct: 73 VCEASLKRLGTDYLDLICCIGGGVC---LAETIETMEALQAAGKIRRWGVSNLDTDDM-E 128
Query: 163 SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEI 222
A +Q+ Y+L R P E L+ +++ + +MAY+P+E+G L +N L +
Sbjct: 129 EWIAAGGQACTTDQILYNLTRRGP-EFDLIPLLRKHHMPVMAYSPVEQGRLLKNPALIAL 187
Query: 223 GKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAM 263
+ T AQ+ L +++ +++AIPKA + H+KENF ++
Sbjct: 188 AQALNVTPAQLGLAWVMRHPDIMAIPKAGHVAHVKENFASL 228
>pir||G72546 probable K+ channel beta 1 subunit APE1659 - Aeropyrum pernix
(strain K1) >gi|5105347|dbj|BAA80660.1| (AP000062) 335aa
long hypothetical K+ channel beta 1 subunit [Aeropyrum
pernix]
Length = 335
Score = 130 bits (323), Expect = 2e-29
Identities = 92/283 (32%), Positives = 140/283 (48%), Gaps = 34/283 (12%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLEL----GINLIDTAEFYGAGHSEELV 73
+V+ +G+G W G P + S + L GL + GINL+DTAE YG G SE ++
Sbjct: 13 RVSRVGLGLWQFGS---PMWGGKALSADVLARGLSIAVEEGINLLDTAEVYGMGSSERML 69
Query: 74 GKAIEGFN-REEIFIVSKVWPTHFGYESAKKAARASAKRLGTYIDLYLLHWPGDTWKKIE 132
G+A++ N RE+ IVSKV K AR A RL + D+ L HWP + ++
Sbjct: 70 GEALKRLNAREDFVIVSKVAGFRSTAGDIVKGARGIAGRLSSAPDVILHHWPPPVYSRLC 129
Query: 133 ETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLL 192
+ LE+ V+EGL Y G SN+ +LL + R+ E V +Q+ Y+L RTPE+ L+
Sbjct: 130 SVVRGLEQAVNEGLASYYGFSNYGEDLLGDALSCTRRLEPVADQILYNLAYRTPEQR-LI 188
Query: 193 DYMKREGITLMAYTPLEKGILARNK------------------------CLAEIGKRYGK 228
+ + G+T +A++PL KG LA K L + +R G
Sbjct: 189 PLLHQHGMTPIAWSPLAKGALAGFKGEPTRAQAGDPVFRTALEDTGLQEVLESVARRLGA 248
Query: 229 TSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ A VAL ++ + + V I + ++E A +LS ED
Sbjct: 249 SKASVALAWVAY-KGAVPIVGWRRPERVREAAAAARLKLSEED 290
>pir||A72308 oxidoreductase, aldo/keto reductase family - Thermotoga maritima
(strain MSB8) >gi|4981536|gb|AAD36074.1|AE001762_1
(AE001762) oxidoreductase, aldo/keto reductase family
[Thermotoga maritima]
Length = 286
Score = 129 bits (321), Expect = 4e-29
Identities = 95/245 (38%), Positives = 139/245 (55%), Gaps = 32/245 (13%)
Query: 45 EALRYGLELGINLIDTAEFYGAGHSEELVGKAI-----EGF-NREEIFIVSKVWPTHFGY 98
E + +++G LIDTA Y +EE VG+AI EG REE+F+ +K+W + GY
Sbjct: 31 ECVYEAIKVGYRLIDTAASY---MNEEGVGRAIKRAIDEGIVRREELFVTTKLWVSDVGY 87
Query: 99 ESAKKAARASAKRLG-TYIDLYLLHWP-GD---TWKKIEETLHALEELVDEGLIRYIGVS 153
ES KKA S K+L YIDLYL+H P GD WK A+EE+ +GL+R IGVS
Sbjct: 88 ESTKKAFEKSLKKLQLEYIDLYLIHQPFGDVHCAWK-------AMEEMYKDGLVRAIGVS 140
Query: 154 NFDLELLRRSQEAMRKYEIV--VNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKG 211
NF + R + M +EIV VNQ++ + EE +++M+ I A+ P +G
Sbjct: 141 NFYPD---RLMDLMVHHEIVPAVNQIEIHPFYQRQEE---IEFMRNYNIQPEAWGPFAEG 194
Query: 212 --ILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSR 269
+ +N L I ++YGKT AQV L +L ++ +VAIPK ++ +KEN + L++
Sbjct: 195 RKNIFQNGVLRSIAEKYGKTVAQVILRWLT-QKGIVAIPKTVRRERMKENISIFDFELTQ 253
Query: 270 EDRER 274
ED E+
Sbjct: 254 EDMEK 258
>pir||A32950 probable aldehyde reductase (EC 1.1.1.-) - Leishmania major
Length = 284
Score = 127 bits (317), Expect = 1e-28
Identities = 91/263 (34%), Positives = 136/263 (51%), Gaps = 25/263 (9%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ G+G W E + A+++ L G IDTA Y +EE VG +
Sbjct: 16 KMPQFGLGVWQSPAGEVTE--------NAVKWALCAGYRHIDTAAIY---KNEESVGAGL 64
Query: 78 E--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------GDTW 128
G RE++FI +K+W T GYES A S ++LG YIDLYL+HWP
Sbjct: 65 RASGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWPRGKDILSKEG 124
Query: 129 KKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEE 188
KK ++ A E+L E +R IGVSNF + L AM +VNQV+ ++ +
Sbjct: 125 KKYLDSWRAFEQLYKEKKVRAIGVSNFHIHHL-EDVLAMCTVTPMVNQVELHPLN---NQ 180
Query: 189 TGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIP 248
L + + I + A++PL +G L N L+ IG +Y KT+AQV L + I ++N++ IP
Sbjct: 181 ADLRAFCDAKQIKVEAWSPLGQGKLLSNPILSAIGAKYNKTAAQVILRWNI-QKNLITIP 239
Query: 249 KASNKDHIKENFGAMGWRLSRED 271
K+ +++ I+EN + L ED
Sbjct: 240 KSVHRERIEENADIFDFELGAED 262
>sp|P22045|P100_LEIMA PROBABLE REDUCTASE >gi|603456|gb|AAA57350.1| (J04483) reductase
[Leishmania major]
Length = 284
Score = 127 bits (315), Expect = 2e-28
Identities = 91/263 (34%), Positives = 135/263 (50%), Gaps = 25/263 (9%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ G+G W E + A+ + L G IDTA Y +EE VG +
Sbjct: 16 KMPQFGLGVWQSPAGEVTE--------NAVNWALCAGYRHIDTAAIY---KNEESVGAGL 64
Query: 78 E--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------GDTW 128
G RE++FI +K+W T GYES A S ++LG YIDLYL+HWP
Sbjct: 65 RASGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWPRGKDILSKEG 124
Query: 129 KKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEE 188
KK ++ A E+L E +R IGVSNF + L AM +VNQV+ ++ +
Sbjct: 125 KKYLDSWRAFEQLYKEKKVRAIGVSNFHIHHL-EDVLAMCTVTPMVNQVELHPLN---NQ 180
Query: 189 TGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIP 248
L + + I + A++PL +G L N L+ IG +Y KT+AQV L + I ++N++ IP
Sbjct: 181 ADLRAFCDAKQIKVEAWSPLGQGKLLSNPILSAIGAKYNKTAAQVILRWNI-QKNLITIP 239
Query: 249 KASNKDHIKENFGAMGWRLSRED 271
K+ +++ I+EN + L ED
Sbjct: 240 KSVHRERIEENADIFDFELGAED 262
>pir||A59021 aldehyde reductase (EC 1.1.1.21) [validated] - pig
>gi|294212|gb|AAA30989.1| (L14950) aldose reductase [Sus
scrofa] >gi|1184820|gb|AAC48515.1| (U46065) aldose
reductase [Sus scrofa]
Length = 316
Score = 125 bits (310), Expect = 7e-28
Identities = 94/290 (32%), Positives = 145/290 (49%), Gaps = 52/290 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY------GAGHSEE 71
K+ +G+GTW S + EA++ ++LG ID A Y G G E+
Sbjct: 12 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 62
Query: 72 LVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
L G+ ++ RE++FIVSK+W T K A + + + L Y+DLYL+HWP
Sbjct: 63 LQGQVVK---REDLFIVSKLWCTDHEKNLVKGACQTTLRNLKLDYLDLYLIHWPTGFKPG 119
Query: 125 -------GD-----TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
GD ET A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 120 KDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 179
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAE 221
VNQ++ + + L++Y K +GI + AY+PL E L + +
Sbjct: 180 PAVNQIE---VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKA 236
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I +Y KT+AQV + + + + N++ IPK+ + I ENF + LS ED
Sbjct: 237 IAAKYNKTTAQVLIRFPM-QRNLIVIPKSVTPERIAENFQVFDFELSPED 285
>sp|P80874|GS69_BACSU GENERAL STRESS PROTEIN 69 (GSP69) >gi|7447930|pir||D69826 aldo/keto
reductase homolog yhdN - Bacillus subtilis
>gi|2226209|emb|CAA74498.1| (Y14082) hypothetical
protein [Bacillus subtilis] >gi|2633288|emb|CAB12792.1|
(Z99109) similar to aldo/keto reductase [Bacillus
subtilis]
Length = 331
Score = 124 bits (309), Expect = 1e-27
Identities = 101/309 (32%), Positives = 154/309 (49%), Gaps = 51/309 (16%)
Query: 10 DFKRIGDDKVTA--IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAG 67
++ I D + A IG+GTW IGG + + ++ SIE +R L+ GI LIDTA YG G
Sbjct: 2 EYTSIADTGIEASRIGLGTWAIGGTMWGG-TDEKTSIETIRAALDQGITLIDTAPAYGFG 60
Query: 68 HSEELVGKAIEGF-NREEIFIVSKV---WPTHFGYESAKKA-----ARASAKRLGT-YID 117
SEE+VGKAI+ + R+++ + +K W + + A +A S KRL T YID
Sbjct: 61 QSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYID 120
Query: 118 LYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQV 177
LY +HWP D IEET ++EL D G IR IGVSNF +E + + + I Q
Sbjct: 121 LYQVHWP-DPLVPIEETAEVMKELYDAGKIRAIGVSNFSIEQMDTFRAVAPLHTI---QP 176
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA--------------RN------- 216
Y+L +R EE+ +L Y K IT + Y L +G+L RN
Sbjct: 177 PYNLFEREMEES-VLPYAKDNKITTLLYGSLCRGLLTGKMTEEYTFEGDDLRNHDPKFQK 235
Query: 217 ----KCLAEIGK-------RYGKTSAQVALNYLIWEENV-VAIPKASNKDHIKENFGAMG 264
+ L+ + + RYGK+ +A+ +++ + +A+ A ++ G
Sbjct: 236 PRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADIALWGARKPGQLEALSEITG 295
Query: 265 WRLSREDRE 273
W L+ ED++
Sbjct: 296 WTLNSEDQK 304
>sp|P80276|ALDR_PIG ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE)
Length = 316
Score = 124 bits (308), Expect = 1e-27
Identities = 94/290 (32%), Positives = 145/290 (49%), Gaps = 52/290 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY------GAGHSEE 71
K+ +G+GTW S + EA++ ++LG ID A Y G G E+
Sbjct: 12 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 62
Query: 72 LVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
L G+ ++ RE++FIVSK+W T K A + + + L Y+DLYL+HWP
Sbjct: 63 LQGQVVK---REDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPG 119
Query: 125 -------GD-----TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
GD ET A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 120 KDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 179
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAE 221
VNQ++ + + L++Y K +GI + AY+PL E L + +
Sbjct: 180 PAVNQIE---VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKA 236
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I +Y KT+AQV + + + + N++ IPK+ + I ENF + LS ED
Sbjct: 237 IAAKYNKTTAQVLIRFPM-QRNLIVIPKSVTPERIAENFQVFDFELSPED 285
>pdb|1DLA|B Chain B, Aldose Reductase (E.C.1.1.1.21) >gi|515112|pdb|1DLA|C
Chain C, Aldose Reductase (E.C.1.1.1.21)
>gi|515110|pdb|1DLA|A Chain A, Aldose Reductase
(E.C.1.1.1.21) >gi|515113|pdb|1DLA|D Chain D, Aldose
Reductase (E.C.1.1.1.21)
Length = 314
Score = 124 bits (308), Expect = 1e-27
Identities = 94/290 (32%), Positives = 145/290 (49%), Gaps = 52/290 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY------GAGHSEE 71
K+ +G+GTW S + EA++ ++LG ID A Y G G E+
Sbjct: 10 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 60
Query: 72 LVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
L G+ ++ RE++FIVSK+W T K A + + + L Y+DLYL+HWP
Sbjct: 61 LQGQVVK---REDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPG 117
Query: 125 -------GD-----TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
GD ET A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 118 KDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 177
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAE 221
VNQ++ + + L++Y K +GI + AY+PL E L + +
Sbjct: 178 PAVNQIE---VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKA 234
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I +Y KT+AQV + + + + N++ IPK+ + I ENF + LS ED
Sbjct: 235 IAAKYNKTTAQVLIRFPM-QRNLIVIPKSVTPERIAENFQVFDFELSPED 283
>pdb|1AH0| Pig Aldose Reductase Complexed With Sorbinil
Length = 316
Score = 124 bits (308), Expect = 1e-27
Identities = 94/290 (32%), Positives = 145/290 (49%), Gaps = 52/290 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY------GAGHSEE 71
K+ +G+GTW S + EA++ ++LG ID A Y G G E+
Sbjct: 12 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 62
Query: 72 LVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
L G+ ++ RE++FIVSK+W T K A + + + L Y+DLYL+HWP
Sbjct: 63 LQGQVVK---REDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPG 119
Query: 125 -------GD-----TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
GD ET A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 120 KDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 179
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAE 221
VNQ++ + + L++Y K +GI + AY+PL E L + +
Sbjct: 180 PAVNQIE---VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKA 236
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I +Y KT+AQV + + + + N++ IPK+ + I ENF + LS ED
Sbjct: 237 IAAKYNKTTAQVLIRFPM-QRNLIVIPKSVTPERIAENFQVFDFELSPED 285
>pdb|1EKO|A Chain A, Pig Aldose Reductase Complexed With Idd384 Inhibitor
>gi|3114350|pdb|1AH4| Pig Aldose Reductase, Holo Form
>gi|3114349|pdb|1AH3| Aldose Reductase Complexed With
Tolrestat Inhibitor
Length = 315
Score = 124 bits (308), Expect = 1e-27
Identities = 94/290 (32%), Positives = 145/290 (49%), Gaps = 52/290 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY------GAGHSEE 71
K+ +G+GTW S + EA++ ++LG ID A Y G G E+
Sbjct: 11 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 61
Query: 72 LVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
L G+ ++ RE++FIVSK+W T K A + + + L Y+DLYL+HWP
Sbjct: 62 LQGQVVK---REDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPG 118
Query: 125 -------GD-----TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
GD ET A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 119 KDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 178
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAE 221
VNQ++ + + L++Y K +GI + AY+PL E L + +
Sbjct: 179 PAVNQIE---VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKA 235
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I +Y KT+AQV + + + + N++ IPK+ + I ENF + LS ED
Sbjct: 236 IAAKYNKTTAQVLIRFPM-QRNLIVIPKSVTPERIAENFQVFDFELSPED 284
>gb|AAG19006.1| (AE005000) aldehyde reductase; YafB [Halobacterium sp. NRC-1]
Length = 277
Score = 123 bits (307), Expect = 2e-27
Identities = 86/271 (31%), Positives = 146/271 (53%), Gaps = 20/271 (7%)
Query: 4 KMAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEF 63
+MA+ + + +++ G+GTW E D S +S+ R LE+G IDTA+
Sbjct: 2 RMAQDTQQRAAVVEEMPEFGLGTW-----ENEDPSACADSV---RTALEMGYRHIDTAQI 53
Query: 64 YGAGHSEELVGKAIEG--FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYL 120
Y +E+ VG I +RE++F+ +KVW + G A S ++LG Y+DL
Sbjct: 54 Y---ENEDAVGDGIAAADVDREDVFLATKVWTSELGDGDVAPATEQSLEKLGVDYVDLLY 110
Query: 121 LHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS 180
+HWP + + E TL AL +L +G+ IGVSNF+ L +++ + + NQV++
Sbjct: 111 VHWPANQYDATE-TLAALADLQADGVTERIGVSNFEPRHLDEAEDVLGELPFA-NQVEFH 168
Query: 181 LMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIW 240
+ + E L +Y E I L+AY+PL +G + + + +++G + AQV+L + +
Sbjct: 169 PLLQQEE---LREYADGEDIELVAYSPLARGEVFDVPEIQAVAEKHGVSEAQVSLAW-VR 224
Query: 241 EENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ V AIPKA+ +DHI +N+ ++ L ED
Sbjct: 225 RKGVTAIPKATGEDHIADNWASLDLELDDED 255
>pir||H83124 probable oxidoreductase PA4167 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950375|gb|AAG07554.1|AE004833_5
(AE004833) probable oxidoreductase [Pseudomonas
aeruginosa]
Length = 272
Score = 121 bits (301), Expect = 8e-27
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 24/260 (9%)
Query: 21 AIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI--E 78
+ G+GT+ + G+ ++++R LELG IDTA+ YG +E +G+AI
Sbjct: 10 SFGLGTFRLTGQVV---------VDSVRSALELGYRAIDTAQIYG---NEADIGRAIAES 57
Query: 79 GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGD-TWKKIEETLH 136
G R E+F+ +KVW ++ E + R S ++L T +DL L+HWP ++ E +
Sbjct: 58 GVPRSELFLTTKVWVDNYAREKLLASLRESLEKLRTDRLDLVLIHWPAPGNGVELGEYMA 117
Query: 137 ALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS--LMDRTPEETGLLDY 194
AL E GL R IGVSNF++EL R++ A+ EI NQ++ S L +R L Y
Sbjct: 118 ALAEAKSLGLTRRIGVSNFNIELTRQAIAAVGAGEISTNQIELSPYLQNR-----ALTAY 172
Query: 195 MKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKD 254
++ +GI + +Y L G + ++ LA I R+ T AQVAL + + + IP ++ ++
Sbjct: 173 LEEQGIAVTSYMTLAYGKVLKDPTLAGIAARHRATVAQVALAWAM-QLGYAVIPSSTRRE 231
Query: 255 HIKENFGAMGWRLSREDRER 274
++ N A RL ED R
Sbjct: 232 NLASNLLARDLRLDAEDMAR 251
>pir||T34993 probable oxidoreductase - Streptomyces coelicolor
>gi|4007669|emb|CAA22355.1| (AL034443) putative
oxidoreductase [Streptomyces coelicolor A3(2)]
Length = 277
Score = 121 bits (301), Expect = 8e-27
Identities = 90/255 (35%), Positives = 133/255 (51%), Gaps = 23/255 (9%)
Query: 22 IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI--EG 79
+G G W + D ++ A+ LE G IDTA YG +EE G+AI G
Sbjct: 19 LGFGVWQV---------PDDDAQTAVALALEAGYRSIDTAAIYG---NEEGTGRAIAASG 66
Query: 80 FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHAL 138
RE++F+ +K+W + GY+S +A S +LG Y+DLYL+HWP ++ +T A
Sbjct: 67 LAREDLFVTTKLWNSDQGYDSTLRAFDTSMAKLGLEYLDLYLIHWPMPAKERYVDTYKAF 126
Query: 139 EELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKRE 198
E+L+ +G +R IGVSNF E L R A VNQ++ + ++ + +
Sbjct: 127 EKLLADGRVRAIGVSNFLPEHLER-LTAETSVIPAVNQIE---LHPHLQQHAAREVHAEQ 182
Query: 199 GITLMAYTPL--EKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHI 256
GI A++PL KGIL +A I +++G+T AQV L + + NVV IPK+ I
Sbjct: 183 GIATEAWSPLGSGKGILDIPAIVA-IAQKHGRTPAQVVLRWHLQLGNVV-IPKSVTPSRI 240
Query: 257 KENFGAMGWRLSRED 271
KEN G+ L ED
Sbjct: 241 KENIDVFGFSLDTED 255
>pir||C83506 probable oxidoreductase PA1127 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9947046|gb|AAG04516.1|AE004542_12
(AE004542) probable oxidoreductase [Pseudomonas
aeruginosa]
Length = 329
Score = 120 bits (298), Expect = 2e-26
Identities = 101/302 (33%), Positives = 146/302 (47%), Gaps = 52/302 (17%)
Query: 16 DDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
D V+ IG+GTW IGG + + D S+E +R +E GINLIDTA YG GHSEE+VGK
Sbjct: 12 DTPVSRIGLGTWAIGGWMWGG-ADDATSVETIRRAVESGINLIDTAPVYGFGHSEEVVGK 70
Query: 76 AIEGFNREEIFIVSKV---WPTHFGYESAKKAARA------SAKRLGT-YIDLYLLHWPG 125
A++G R++ I +K W + G AAR S +RL T IDLY +HWP
Sbjct: 71 ALQGL-RDKAVIATKAALEW-SDAGIHRNASAARIRREVEDSLRRLKTDRIDLYQIHWP- 127
Query: 126 DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN-QVKYSLMDR 184
D EET LE L +G I IGVSN+ E + R++ + + Q Y+L +R
Sbjct: 128 DPLVAHEETAGELERLRRDGKILAIGVSNYSPE----QMDGFRQFAPLASVQPPYNLFER 183
Query: 185 TPEETGLLDYMKREGITLMAYTPLEKGILARN-------------------------KCL 219
+ +L Y +R GI ++AY L +G+L+ + L
Sbjct: 184 A-IDADVLPYAERNGIVVLAYGALCRGLLSGRMNAETRFDGDDLRKSDPKFQQPRFAQYL 242
Query: 220 AEIG-------KRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDR 272
A + +RYGK+ +A+ +++ VA+ A + + A GWRL E
Sbjct: 243 AAVAQLEELARERYGKSVLALAIRWILDRGPTVALWGARKPEQLNGIADAFGWRLDDEAM 302
Query: 273 ER 274
R
Sbjct: 303 AR 304
>sp|P46336|IOLS_BACSU IOLS PROTEIN (VEGETATIVE PROTEIN 147) (VEG147)
>gi|7447927|pir||D69646 myo-inositol catabolism iolS -
Bacillus subtilis >gi|904205|dbj|BAA21607.1| (AB005554)
plausibly involved in inositol catabolism [Bacillus
subtilis] >gi|2636524|emb|CAB16014.1| (Z99124) alternate
gene name: yxbF~myo-inositol catabolism [Bacillus
subtilis]
Length = 310
Score = 119 bits (296), Expect = 3e-26
Identities = 95/297 (31%), Positives = 140/297 (46%), Gaps = 46/297 (15%)
Query: 16 DDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
D +V IG+GT +GG + E +R + G+ ++DTA YG G SEEL+G+
Sbjct: 10 DLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGE 69
Query: 76 AIEGFNREEIFIVSKVWPTHFGYESA--------KKAARASAKRLGT-YIDLYLLHWPGD 126
+ FNRE++ I +K G + KK+ S KRL T YIDL+ +H+P +
Sbjct: 70 VLREFNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFPDE 129
Query: 127 TWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTP 186
K +E ++AL E+ G IR IGVSNF LE L+ EA + + V Q +Y+L++R
Sbjct: 130 HTPK-DEAVNALNEMKKAGKIRSIGVSNFSLEQLK---EANKDGLVDVLQGEYNLLNREA 185
Query: 187 EETGLLDYMKREGITLMAYTPLEKGILA--------------RNK--------------- 217
E+T Y K I+ + Y PL G+LA RN+
Sbjct: 186 EKT-FFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLRNEQEHFKGERFKENIRK 244
Query: 218 --CLAEIGKRYGKTSAQVALN-YLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
LA I +++ + L YL E + IP A D + +N LS+ED
Sbjct: 245 VNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQLIDNIKTADVTLSQED 301
>pir||E75296 aldo/keto reductase - Deinococcus radiodurans (strain R1)
>gi|6460065|gb|AAF11806.1|AE002058_6 (AE002058)
aldo/keto reductase [Deinococcus radiodurans]
Length = 327
Score = 119 bits (295), Expect = 4e-26
Identities = 89/304 (29%), Positives = 151/304 (49%), Gaps = 51/304 (16%)
Query: 12 KRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEE 71
+++ D V+A+G+G G+ EF + + ES+ L L+LG+ DTA+ YG H+EE
Sbjct: 7 RQLRDLTVSALGLGCMGMS--EFYGDADEAESLRTLDRALDLGVTFFDTADIYGPYHNEE 64
Query: 72 LVGKAIEGFNREEIFIVSKVW-------PTHFGY----ESAKKAARASAKRLGT-YIDLY 119
L+G+ + G R+ + + +K P+ G+ E +++ S RLGT ++DLY
Sbjct: 65 LLGRWLRG-KRDRVVLATKFGIVRDPADPSRRGFSGRPEYVRQSIEGSLNRLGTDHVDLY 123
Query: 120 LLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKY 179
LH D IE+T+ A+ +LV EG +R +G+S + LRR+ + I Q +Y
Sbjct: 124 YLH-RVDPDTPIEDTVGAMADLVQEGKVRALGLSECSADTLRRAHAV---HPISAVQSEY 179
Query: 180 SLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARN----------------------- 216
SL R PEE G+L + G+ + Y+PL +G LA
Sbjct: 180 SLWTRDPEENGVLAACRELGVGFVPYSPLGRGFLAGQLKSPDDLAPDDFRRHNPRFQDEN 239
Query: 217 --------KCLAEIGKRYGKTSAQVALNYLIWE-ENVVAIPKASNKDHIKENFGAMGWRL 267
+ + + G T +Q+AL +++ + EN+V IP +++EN GA+ RL
Sbjct: 240 FQKNLDLVREIERLAAEKGCTPSQLALAWVLAQGENLVPIPGTKRVKYLEENVGALDVRL 299
Query: 268 SRED 271
+ ++
Sbjct: 300 TPDE 303
>pir||A35452 aldehyde reductase (EC 1.1.1.21) - bovine
Length = 315
Score = 118 bits (294), Expect = 6e-26
Identities = 90/293 (30%), Positives = 143/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++LG ID A Y +E VG A+
Sbjct: 11 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVY---QNENEVGLAL 58
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGD---- 126
+ RE++FIVSK+W T+ + K A + + L Y+DLYL+HWP
Sbjct: 59 QAKLQEKVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 118
Query: 127 --------------TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ K +T A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 119 KDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 178
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L+ Y +GI + AY+PL E + +
Sbjct: 179 PAVNQIECHPYLTQEK------LIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPR 232
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I +Y KT+AQV + + I + N++ IPK+ + I ENF + L +ED
Sbjct: 233 IKAIADKYNKTTAQVLIRFPI-QRNLIVIPKSVTPERIAENFQVFDFELDKED 284
>gi|6978491 aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI
fragment, probably the functional gene) [Rattus
norvegicus] >gi|1168407|sp|P07943|ALDR_RAT ALDOSE
REDUCTASE (AR) (ALDEHYDE REDUCTASE)
>gi|320179|pir||A60603 aldehyde reductase (EC 1.1.1.21)
- rat >gi|55759|emb|CAA29308.1| (X05884) aldose
reductase [Rattus norvegicus] >gi|202852|gb|AAA40721.1|
(M60322) aldose reductase [Rattus norvegicus]
Length = 316
Score = 118 bits (294), Expect = 6e-26
Identities = 92/293 (31%), Positives = 146/293 (49%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ +++G ID A+ Y +E+ VG A+
Sbjct: 12 KMPTLGLGTWK---------SPPGQVTEAVKVAIDMGYRHIDCAQVY---QNEKEVGVAL 59
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----G 125
+ R+++FIVSK+W T K A + + L Y+DLYL+HWP G
Sbjct: 60 QEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPG 119
Query: 126 DTWKKIE-------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ ++ +T A+E+LVDEGL++ IGVSNF+ L++ R + KY+
Sbjct: 120 PDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L++Y +GI + AY+PL E L +
Sbjct: 180 PAVNQIECHPYLTQEK------LIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPR 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI +Y KT+AQV + + I + N+V IPK+ I ENF + LS ED
Sbjct: 234 IKEIAAKYNKTTAQVLIRFPI-QRNLVVIPKSVTPARIAENFKVFDFELSNED 285
>sp|P16116|ALDR_BOVIN ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE) (20-ALPHA-HYDROXYSTEROID
DEHYDROGENASE) (20-ALPHA-HSD)
Length = 315
Score = 118 bits (294), Expect = 6e-26
Identities = 90/293 (30%), Positives = 143/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++LG ID A Y +E VG A+
Sbjct: 11 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVY---QNENEVGLAL 58
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGD---- 126
+ RE++FIVSK+W T+ + K A + + L Y+DLYL+HWP
Sbjct: 59 QAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 118
Query: 127 --------------TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ K +T A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 119 KDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 178
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L+ Y +GI + AY+PL E + +
Sbjct: 179 PAVNQIECHPYLTQEK------LIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPR 232
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I +Y KT+AQV + + I + N++ IPK+ + I ENF + L +ED
Sbjct: 233 IKAIADKYNKTTAQVLIRFPI-QRNLIVIPKSVTPERIAENFQVFDFELDKED 284
>gb|AAB25333.1| (S54973) 20 alpha-hydroxysteroid dehydrogenase, 20 alpha-HSD,
alditol:NADPH oxidoreductase, aldose reductase {EC
1.1.1.21} [cattle, testes, Peptide Partial, 307 aa] [Bos
taurus]
Length = 307
Score = 118 bits (294), Expect = 6e-26
Identities = 90/293 (30%), Positives = 143/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++LG ID A Y +E VG A+
Sbjct: 3 KMPILGLGTWK---------SPPGKVTEAVKVAIDLGYRHIDCAHVY---QNENEVGLAL 50
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGD---- 126
+ RE++FIVSK+W T+ + K A + + L Y+DLYL+HWP
Sbjct: 51 QAKLQEKVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 110
Query: 127 --------------TWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ K +T A+EELVDEGL++ IGVSNF+ L++ + + KY+
Sbjct: 111 KDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYK 170
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L+ Y +GI + AY+PL E + +
Sbjct: 171 PAVNQIECHPYLTQEK------LIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPR 224
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I +Y KT+AQV + + I + N++ IPK+ + I ENF + L +ED
Sbjct: 225 IKAIADKYNKTTAQVLIRFPI-QRNLIVIPKSVTPERIAENFQVFDFELDKED 276
>gb|AAF49912.1| (AE003541) CG10638 gene product [Drosophila melanogaster]
Length = 317
Score = 118 bits (294), Expect = 6e-26
Identities = 97/285 (34%), Positives = 141/285 (49%), Gaps = 53/285 (18%)
Query: 22 IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI---- 77
+G+GT+ SKD E A+++ +++G IDTA FY +E VGKAI
Sbjct: 18 LGLGTYN---------SKDNEGEAAVKHAIDVGYRHIDTAYFY---QNEAEVGKAIRDKI 65
Query: 78 -EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEE- 133
EG RE+IF+V+K+W E + R G YIDLYL+H P +K +++
Sbjct: 66 AEGVVKREDIFLVTKLWNIFHDPERVEGICRKQLSNFGLDYIDLYLMHMPVG-YKYVDDN 124
Query: 134 --------------------TLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV 173
T A+E+LV GL+R IGVSNF+ E L R A + + V
Sbjct: 125 TLLPKNEDDVLQLSDVDYLDTYKAMEKLVKLGLVRSIGVSNFNSEQLARVL-ANCEIKPV 183
Query: 174 VNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-------EKGILARNKCLAEIGKRY 226
NQV+ S + L + K+ +TL YTPL +K + +A I K+Y
Sbjct: 184 TNQVECS---PALNQKALTAFCKKNDVTLTGYTPLGKPKPDIQKPDFIYSPEVAVIAKKY 240
Query: 227 GKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
GKT+ Q+ L YL+ V+ IPK+SN + I ENF + L+ E+
Sbjct: 241 GKTTPQIVLRYLV-GLGVIPIPKSSNTNRISENFDIFDFELTAEE 284
>sp|P21300|ALD1_MOUSE ALDOSE REDUCTASE-RELATED PROTEIN 1 (AR) (ALDEHYDE REDUCTASE) (VAS
DEFERENS ANDROGEN-DEPENDENT PROTEIN) (MVDP)
>gi|199900|gb|AAA39774.1| (M81448) aldose reductase [Mus
musculus]
Length = 316
Score = 118 bits (292), Expect = 1e-25
Identities = 94/290 (32%), Positives = 146/290 (49%), Gaps = 52/290 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW K P K EA++ ++ G ID A Y H+E VG+AI
Sbjct: 12 KMPLVGLGTW----KSSPGQVK-----EAVKAAIDAGYRHIDCAYVY---HNENEVGEAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
+ RE++FIVSK+W T F KKA + + L Y+DLYL+HWP
Sbjct: 60 QEKIKENAVKREDLFIVSKLWATFFEKSLVKKAFQNTLSDLKLDYLDLYLVHWPQGFQAG 119
Query: 126 ------DTWKKIE-------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
D K+ + A+EELVD+GL++ +G+SNF+ ++ R + K++
Sbjct: 120 NALLPKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHK 179
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAE 221
V NQ++ S T E+ L+ Y + +GI + AY+PL E ++ + E
Sbjct: 180 PVTNQIE-SHPYLTQEK--LIQYCQSKGIAVTAYSPLGSPDRPYAKPEDPVVMEIPKIKE 236
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I ++ KT AQV + + + + NVV IPK+ I+EN ++LS ED
Sbjct: 237 IAAKHKKTVAQVLIRFHV-QRNVVVIPKSVTPSRIQENLQVFDFQLSEED 285
>gb|AAC36465.1| (AF052577) aldo-keto reductase [Homo sapiens]
Length = 316
Score = 117 bits (291), Expect = 1e-25
Identities = 93/293 (31%), Positives = 145/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++ G ID A Y +E VG+AI
Sbjct: 12 KMPIVGLGTWK---------SPLGKVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWP------ 124
+ RE++FIVSK+WPT F +KA + K L +Y+D+YL+HWP
Sbjct: 60 QEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG 119
Query: 125 GDTWKKIE------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
D + K + + A+EELVDEGL++ +GVSNF ++ + + KY+
Sbjct: 120 DDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L+ Y +GIT+ AY+PL E L +
Sbjct: 180 PVTNQVECHPYLTQEK------LIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPK 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI ++ KT+AQV + + I + NV+ IPK+ I EN ++LS E+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHI-QRNVIVIPKSVTPARIVENIQVFDFKLSDEE 285
>gi|4757742 aldo-keto reductase family 1, member B11 (aldose reductase-like);
aldose reductase-like 1 [Homo sapiens]
>gi|3150035|gb|AAC17469.1| (U37100) aldose
reductase-like peptide [Homo sapiens]
Length = 316
Score = 117 bits (291), Expect = 1e-25
Identities = 93/293 (31%), Positives = 145/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++ G ID A Y +E VG+AI
Sbjct: 12 KMPIVGLGTWK---------SPLGKVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWP------ 124
+ RE++FIVSK+WPT F +KA + K L +Y+D+YL+HWP
Sbjct: 60 QEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG 119
Query: 125 GDTWKKIE------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
D + K + + A+EELVDEGL++ +GVSNF ++ + + KY+
Sbjct: 120 DDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L+ Y +GIT+ AY+PL E L +
Sbjct: 180 PVTNQVECHPYLTQEK------LIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPK 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI ++ KT+AQV + + I + NV+ IPK+ I EN ++LS E+
Sbjct: 234 IKEIAAKHKKTAAQVLIRFHI-QRNVIVIPKSVTPARIVENIQVFDFKLSDEE 285
>gb|AAC53199.1| (U81045) aldo-keto reductase [Cricetulus griseus]
Length = 316
Score = 117 bits (291), Expect = 1e-25
Identities = 96/299 (32%), Positives = 148/299 (49%), Gaps = 60/299 (20%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++ G ID A Y ++E VG+AI
Sbjct: 12 KMPIVGLGTW---------QSPPGQVKEAVKVAIDAGYRHIDCAYAY---YNEHEVGEAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKK 130
+ RE++FIVSK+WPT F + K+A + + L Y+DLYL+HWP
Sbjct: 60 QEKIKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPG 119
Query: 131 IE------------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
E + +EELVDEGL++ +GVSNF+ ++ R + K++
Sbjct: 120 KELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L++Y +GIT+ AY+PL E L +
Sbjct: 180 PVTNQVECHPYLTQEK------LIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPK 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKL 277
+ EI ++ KTSAQV + + I + NVV IPK+ I ENF ++LS D+E A +
Sbjct: 234 IKEIAAKHKKTSAQVLIRFHI-QRNVVVIPKSVTPARIHENFQVFDFQLS--DQEMATI 289
>pdb|1C9W|A Chain A, Cho Reductase With Nadp+
Length = 315
Score = 117 bits (291), Expect = 1e-25
Identities = 96/299 (32%), Positives = 148/299 (49%), Gaps = 60/299 (20%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++ G ID A Y ++E VG+AI
Sbjct: 11 KMPIVGLGTW---------QSPPGQVKEAVKVAIDAGYRHIDCAYAY---YNEHEVGEAI 58
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKK 130
+ RE++FIVSK+WPT F + K+A + + L Y+DLYL+HWP
Sbjct: 59 QEKIKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPG 118
Query: 131 IE------------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
E + +EELVDEGL++ +GVSNF+ ++ R + K++
Sbjct: 119 KELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHK 178
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L++Y +GIT+ AY+PL E L +
Sbjct: 179 PVTNQVECHPYLTQEK------LIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPK 232
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKL 277
+ EI ++ KTSAQV + + I + NVV IPK+ I ENF ++LS D+E A +
Sbjct: 233 IKEIAAKHKKTSAQVLIRFHI-QRNVVVIPKSVTPARIHENFQVFDFQLS--DQEMATI 288
>gi|11419799 similar to aldo-keto reductase family 1, member B11 (aldose
reductase-like) (H. sapiens) [Homo sapiens]
>gi|11436644|ref|XP_006113.1| aldo-keto reductase family
1, member B11 (aldose reductase-like) [Homo sapiens]
Length = 339
Score = 117 bits (291), Expect = 1e-25
Identities = 93/293 (31%), Positives = 145/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++ G ID A Y +E VG+AI
Sbjct: 35 KMPIVGLGTWK---------SPLGKVKEAVKVAIDAGYRHIDCAYVY---QNEHEVGEAI 82
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWP------ 124
+ RE++FIVSK+WPT F +KA + K L +Y+D+YL+HWP
Sbjct: 83 QEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG 142
Query: 125 GDTWKKIE------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
D + K + + A+EELVDEGL++ +GVSNF ++ + + KY+
Sbjct: 143 DDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYK 202
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L+ Y +GIT+ AY+PL E L +
Sbjct: 203 PVTNQVECHPYLTQEK------LIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPK 256
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI ++ KT+AQV + + I + NV+ IPK+ I EN ++LS E+
Sbjct: 257 IKEIAAKHKKTAAQVLIRFHI-QRNVIVIPKSVTPARIVENIQVFDFKLSDEE 308
>pir||H83328 probable oxidoreductase PA2535 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9948592|gb|AAG05923.1|AE004681_5
(AE004681) probable oxidoreductase [Pseudomonas
aeruginosa]
Length = 331
Score = 117 bits (290), Expect = 2e-25
Identities = 98/295 (33%), Positives = 148/295 (49%), Gaps = 52/295 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDR-ESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
V+AIG+G G+ +F DR E+I L +ELG+N DTA+ YG +EEL+G+A+
Sbjct: 13 VSAIGLGCMGM--TDFYTTGGDRQEAIATLHRAVELGLNFFDTADMYGPHSNEELLGEAL 70
Query: 78 EGFNREEIFIVSKVW-------PTHFGYESA----KKAARASAKRLGT-YIDLYLLHWPG 125
G RE++F+ SK P G + + ++A S KRLGT +DLY H
Sbjct: 71 RG-KREQVFLASKFGIVRDPANPRARGVDGSPAYIRRAIEGSLKRLGTDRLDLYYQH-RM 128
Query: 126 DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRT 185
D IE+++ AL +LV G IR+IG+S E L R A R + I Q +YSL R
Sbjct: 129 DPQVPIEDSVGALADLVKAGKIRHIGLSEASAETLER---AHRVHPISALQSEYSLWTRD 185
Query: 186 PEETGLLDYMKREGITLMAYTPLEKGIL---------------------------ARNKC 218
PE+TG+L +R GI + Y+PL +G L A+N
Sbjct: 186 PEDTGVLAACRRLGIAFVPYSPLGRGFLTGTLKRPEDFAADDYRRFSPRFQGENFAKNLK 245
Query: 219 L----AEIGKRYGKTSAQVALNYLIWE-ENVVAIPKASNKDHIKENFGAMGWRLS 268
L E+ G +Q+AL +++ + ++++ IP + +++EN A RLS
Sbjct: 246 LVDKVGELAAAKGVKPSQLALAWVLAQGDDLIPIPGTKQRRYLEENVAATELRLS 300
>gi|6753148 androgen regulated vas deferens protein [Mus musculus]
>gi|109530|pir||A37990 aldose reductase homolog - mouse
>gi|199898|gb|AAA39773.1| (J05663) vas deferens protein
[Mus musculus]
Length = 316
Score = 116 bits (289), Expect = 2e-25
Identities = 94/290 (32%), Positives = 145/290 (49%), Gaps = 52/290 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW K P K EA++ ++ G ID A Y H+E VG+AI
Sbjct: 12 KMPLVGLGTW----KSSPGQVK-----EAVKAAIDAGYRHIDCAYVY---HNENEVGEAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
+ RE++FIVSK+W T F KKA + L Y+DLYL+HWP
Sbjct: 60 QEKIKENAVKREDLFIVSKLWATFFEKSLVKKAFDNTLSDLKLDYLDLYLVHWPQGFQAG 119
Query: 126 ------DTWKKIE-------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
D K+ + A+EELVD+GL++ +G+SNF+ ++ R + K++
Sbjct: 120 NALLPKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHK 179
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAE 221
V NQ++ S T E+ L+ Y + +GI + AY+PL E ++ + E
Sbjct: 180 PVTNQIE-SHPYLTQEK--LIQYCQSKGIAVTAYSPLGSPDRPYAKPEDPVVMEIPKIKE 236
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I ++ KT AQV + + + + NVV IPK+ I+EN ++LS ED
Sbjct: 237 IAAKHKKTVAQVLIRFHV-QRNVVVIPKSVTPSRIQENLQVFDFQLSEED 285
>sp|P77256|YDJG_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN ANSA-RND INTERGENIC REGION
>gi|7447926|pir||C64937 hypothetical protein b1771 -
Escherichia coli (strain K-12)
>gi|1742882|dbj|BAA15562.1| (D90820) IolS protein.
[Escherichia coli] >gi|1742890|dbj|BAA15569.1| (D90821)
IolS protein. [Escherichia coli]
>gi|1788070|gb|AAC74841.1| (AE000272) orf, hypothetical
protein [Escherichia coli K12]
Length = 326
Score = 115 bits (286), Expect = 5e-25
Identities = 94/308 (30%), Positives = 147/308 (47%), Gaps = 56/308 (18%)
Query: 16 DDKVTAIGMGTWGIGGKEFPDYSKDRE-SIEALRYGLELGINLIDTAEFYGAGHSEELVG 74
D ++ +G+GTW IGG + DR+ I+ + GINLIDTA Y G+SE +VG
Sbjct: 10 DITLSRMGLGTWAIGGGPAWNGDLDRQICIDTILEAHRCGINLIDTAPGYNFGNSEVIVG 69
Query: 75 KAIEGFNREEIFIVSK---VWP---------------THFGYESAKKAARASAKRLG-TY 115
+A++ RE++ + +K VW + ES ++ AS +RLG Y
Sbjct: 70 QALKKLPREQVVVETKCGIVWERKGSLFNKVGDRQLYKNLSPESIREEVAASLQRLGIDY 129
Query: 116 IDLYLLHWPG--DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV 173
ID+Y+ HW + I ET+ L EL EG IR IG +N D + +R E ++ E+
Sbjct: 130 IDIYMTHWQSVPPFFTPIAETVAVLNELKSEGKIRAIGAANVDADHIR---EYLQYGELD 186
Query: 174 VNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA------------------- 214
+ Q KYS++DR E LL + GI + Y+PLE+G+L
Sbjct: 187 IIQAKYSILDRAMENE-LLPLCRDNGIVVQVYSPLEQGLLTGTITRDYVPGGARANKVWF 245
Query: 215 -RNKCLAEIG---------KRYGKTSAQVALNYLIWEENVVAI-PKASNKDHIKENFGAM 263
R L I RY T +AL +++ + ++++I A+ + ++EN A+
Sbjct: 246 QRENMLKVIDMLEQWQPLCARYQCTIPTLALAWILKQSDLISILSGATAPEQVRENVAAL 305
Query: 264 GWRLSRED 271
LS D
Sbjct: 306 NINLSDAD 313
>gi|6679791 fibroblast growth factor regulated protein [Mus musculus]
>gi|1168404|sp|P45377|ALD2_MOUSE ALDOSE
REDUCTASE-RELATED PROTEIN 2 (AR) (ALDEHYDE REDUCTASE)
(FR-1 PROTEIN) >gi|1083210|pir||A53440 aldose reductase
homolog - mouse >gi|463377|gb|AAA16953.1| (U04204)
aldose reductase-related protein [Mus musculus]
Length = 316
Score = 115 bits (284), Expect = 8e-25
Identities = 94/293 (32%), Positives = 145/293 (49%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW K P+ K EA++ ++ G ID A Y +E VG+AI
Sbjct: 12 KMPIVGLGTW----KSPPNQVK-----EAVKAAIDAGYRHIDCAYAYC---NENEVGEAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKK 130
+ RE++FIVSK+WPT F + K+A + + L Y+DLYL+HWP
Sbjct: 60 QEKIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPG 119
Query: 131 IE------------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
E E +EELVD+GL++ +GVSNF+ ++ R + K++
Sbjct: 120 KELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L+ Y +GI++ AY+PL E L +
Sbjct: 180 PVTNQVECHPYLTQEK------LIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPK 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI ++ KTSAQV + + I + NVV IPK+ I+EN ++LS E+
Sbjct: 234 IKEIAAKHEKTSAQVLIRFHI-QRNVVVIPKSVTPSRIQENIQVFDFQLSDEE 285
>pdb|1FRB| Fr-1 ProteinNADPHZOPOLRESTAT COMPLEX
Length = 315
Score = 115 bits (284), Expect = 8e-25
Identities = 94/293 (32%), Positives = 145/293 (49%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW K P+ K EA++ ++ G ID A Y +E VG+AI
Sbjct: 11 KMPIVGLGTW----KSPPNQVK-----EAVKAAIDAGYRHIDCAYAYC---NENEVGEAI 58
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKK 130
+ RE++FIVSK+WPT F + K+A + + L Y+DLYL+HWP
Sbjct: 59 QEKIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPG 118
Query: 131 IE------------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
E E +EELVD+GL++ +GVSNF+ ++ R + K++
Sbjct: 119 KELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHK 178
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L+ Y +GI++ AY+PL E L +
Sbjct: 179 PVTNQVECHPYLTQEK------LIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPK 232
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI ++ KTSAQV + + I + NVV IPK+ I+EN ++LS E+
Sbjct: 233 IKEIAAKHEKTSAQVLIRFHI-QRNVVVIPKSVTPSRIQENIQVFDFQLSDEE 284
>emb|CAB92199.1| (AL356592) oxidoreductase. [Streptomyces coelicolor A3(2)]
Length = 276
Score = 115 bits (284), Expect = 8e-25
Identities = 83/254 (32%), Positives = 131/254 (50%), Gaps = 21/254 (8%)
Query: 21 AIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE-- 78
A+G+GTW + KD E+ A+R LE G LIDTA Y +E VG+ +
Sbjct: 17 ALGLGTWPM---------KDEEAERAVRAALETGYRLIDTATNY---RNETGVGRGVASA 64
Query: 79 GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHA 137
G REEI + +K+ H GYE + S RLG Y+DLYL+HWP K ++ A
Sbjct: 65 GLPREEIVVTTKLPGRHHGYEETLASFEESRARLGLEYVDLYLIHWPLPRVDKYVDSWKA 124
Query: 138 LEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKR 197
+ +L ++GL+R +GVSNF E + R + R+ ++ + + L P++ L Y +R
Sbjct: 125 MVKLREDGLVRSVGVSNFTAEHIERLE---RETGVLPSVNQIELHPLLPQDE-LRAYHER 180
Query: 198 EGITLMAYTPLEKGI-LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHI 256
+GI +++PL +G L + +A + +G T AQ L + + V IPK+++
Sbjct: 181 KGIRTESWSPLGRGSDLLDDPAVAAVAAAHGVTPAQAVLRWHT-QLGAVPIPKSADPARQ 239
Query: 257 KENFGAMGWRLSRE 270
+ N G+ L E
Sbjct: 240 RANLDVFGFELDAE 253
>gb|AAD56034.1|AF182168_1 (AF182168) aldose-reductase-like protein MVDP/AKR1-B7 [Rattus
norvegicus]
Length = 316
Score = 114 bits (283), Expect = 1e-24
Identities = 91/293 (31%), Positives = 144/293 (49%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW K P K EA++ ++ G D A Y +E VG+AI
Sbjct: 12 KMPLVGLGTW----KSPPGQVK-----EAVKAAIDAGYRHFDCAYVY---QNESEVGEAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
+ RE++FIVSK+W T F K+A + + L Y+DLYL+HWP
Sbjct: 60 QEKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAG 119
Query: 126 ------DTWKKIE-------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
D+ K+ + +EELVD+GL++ +GVSNF+ ++ R + K++
Sbjct: 120 KEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
V NQV+ Y ++ L+ Y +GI ++AY+PL E ++
Sbjct: 180 PVTNQVECHPYLTQEK------LIQYCHSKGIVVIAYSPLGSPDRPYAKPEDPVVLEIPK 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI +++ KT AQV + + + + NV IPK+ HIKEN ++LS ED
Sbjct: 234 IKEIARKHKKTIAQVLIRFHV-QRNVAVIPKSVTLSHIKENIQVFDFQLSEED 285
>gb|AAA30370.1| (M31463) aldose reductase (EC 1.1.1.21) [Bos taurus]
Length = 296
Score = 114 bits (282), Expect = 1e-24
Identities = 84/266 (31%), Positives = 133/266 (49%), Gaps = 49/266 (18%)
Query: 45 EALRYGLELGINLIDTAEFYGAGHSEELVGKAIEG------FNREEIFIVSKVWPTHFGY 98
EA++ ++LG ID A Y +E VG A++ RE++FIVSK+W T+
Sbjct: 10 EAVKVAIDLGYRHIDCAHVY---QNENEVGLALQAKLQEKVVKREDLFIVSKLWCTYHDK 66
Query: 99 ESAKKAARASAKRLGT-YIDLYLLHWPGD------------------TWKKIEETLHALE 139
+ K A + + L Y+DLYL+HWP + K +T A+E
Sbjct: 67 DLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAME 126
Query: 140 ELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYEIVVNQVK---YSLMDRTPEETGLLDYM 195
ELVDEGL++ IGVSNF+ L++ + + KY+ VNQ++ Y ++ L+ Y
Sbjct: 127 ELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEK------LIQYC 180
Query: 196 KREGITLMAYTPL----------EKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVV 245
+GI + AY+PL E + + + I +Y KT+AQV + + I + N++
Sbjct: 181 NSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPI-QRNLI 239
Query: 246 AIPKASNKDHIKENFGAMGWRLSRED 271
IPK+ + I ENF + L +ED
Sbjct: 240 VIPKSVTPERIAENFQVFDFELDKED 265
>gb|AAF57392.1| (AE003789) CG9436 gene product [Drosophila melanogaster]
Length = 311
Score = 114 bits (282), Expect = 1e-24
Identities = 93/290 (32%), Positives = 143/290 (49%), Gaps = 60/290 (20%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
++ +G+GTW K F + ++ + R+ L++G +DTA Y +E VG+AI
Sbjct: 15 EMPTLGLGTW----KSF-----ESDAYHSTRHALDVGYRHLDTAFVY---ENEAEVGQAI 62
Query: 78 -----EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
EG REE+F+ +K+ H ++A R S LG Y+DLYL+H P
Sbjct: 63 SEKIAEGVVTREEVFVTTKLGGIHHDPALVERACRLSLSNLGLEYVDLYLMHMPVGQKFH 122
Query: 126 -----------------DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMR 168
DTW++ +E+LVD GL R IG+SNF+ R R
Sbjct: 123 NDSNVHGTLELTDVDYLDTWRE-------MEKLVDLGLTRSIGLSNFNAAQTERVLANCR 175
Query: 169 KYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILAR-------NKCLAE 221
VVNQV+ ++ L ++ KR G+ + AY PL + AR ++
Sbjct: 176 -IRPVVNQVE---CHPGFQQRQLREHAKRHGLVICAYCPLARPQPARQWPPFLYDEHAQN 231
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ K+YG+T+AQ+ L YL+ + VV +PK+SNK I+ENF + LS +D
Sbjct: 232 LAKKYGRTTAQICLRYLV-QLGVVPLPKSSNKARIEENFRVFDFELSPDD 280
>pir||A64745 probable aldehyde reductase (EC 1.1.1.-) yafB - Escherichia coli
(strain K-12) >gi|1552777|gb|AAB08629.1| (U70214)
hypothetical [Escherichia coli]
>gi|1786400|gb|AAC73312.1| (AE000129) putative aldose
reductase (EC 1.1.1.21) [Escherichia coli K12]
Length = 267
Score = 113 bits (281), Expect = 2e-24
Identities = 80/261 (30%), Positives = 137/261 (51%), Gaps = 24/261 (9%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI- 77
+ A G+GT+ + KD I ++ LELG IDTA+ Y +E VG+AI
Sbjct: 3 IPAFGLGTFRL---------KDDVVISSVITALELGYRAIDTAQIYD---NEAAVGQAIA 50
Query: 78 -EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK-KIEET 134
G R E++I +K+W + + + + S ++L T Y+DL L+HWP + +EE
Sbjct: 51 ESGVPRHELYITTKIWIENLSKDKLIPSLKESLQKLRTDYVDLTLIHWPSPNDEVSVEEF 110
Query: 135 LHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS--LMDRTPEETGLL 192
+ AL E +GL R IG+SNF + L+ ++ A+ I NQ++ S L +R ++
Sbjct: 111 MQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRK-----VV 165
Query: 193 DYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASN 252
+ K+ GI + +Y L G +++ +A I ++ T AQV L + + E V IP ++
Sbjct: 166 AWAKQHGIHITSYMTLAYGKALKDEVIARIAAKHNATPAQVILAWAMGEGYSV-IPSSTK 224
Query: 253 KDHIKENFGAMGWRLSREDRE 273
+ +++ N A +L ED++
Sbjct: 225 RKNLESNLKAQNLQLDAEDKK 245
>gi|4502049 aldo-keto reductase family 1, member B1 (aldose reductase);
aldehyde reductase 1 (low Km aldose reductase); aldose
reductase [Homo sapiens] >gi|11419797|ref|XP_004729.1|
aldo-keto reductase family 1, member B1 (aldose
reductase) [Homo sapiens] >gi|11432210|ref|XP_002907.1|
similar to aldo-keto reductase family 1, member B1
(aldose reductase) (H. sapiens) [Homo sapiens]
>gi|113596|sp|P15121|ALDR_HUMAN ALDOSE REDUCTASE (AR)
(ALDEHYDE REDUCTASE) >gi|105249|pir||A39763 aldehyde
reductase (EC 1.1.1.21) - human >gi|8569628|pdb|1EL3|A
Chain A, Human Aldose Reductase Complexed With Idd384
Inhibitor >gi|28647|emb|CAA33460.1| (X15414) aldose
reductase (AA 1-316) [Homo sapiens]
>gi|178485|gb|AAA51712.1| (M59783) aldose reductase
[Homo sapiens] >gi|178487|gb|AAA51713.1| (J04795) aldose
reductase (EC 1.1.1.21) [Homo sapiens]
>gi|178491|gb|AAA51715.1| (J05474) aldose reductase
[Homo sapiens] >gi|179036|gb|AAA35560.1| (M34720) aldose
reductase (EC 1.1.1.21) [Homo sapiens]
>gi|2687578|gb|AAB88851.1| (AF032455) aldose reductase
[Homo sapiens] >gi|449803|prf||1920176A aldose reductase
[Homo sapiens]
Length = 316
Score = 113 bits (280), Expect = 2e-24
Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 62/295 (21%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ +++G ID A Y +E VG AI
Sbjct: 12 KMPILGLGTWK---------SPPGQVTEAVKVAIDVGYRHIDCAHVY---QNENEVGVAI 59
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
+ REE+FIVSK+W T+ K A + + L Y+DLYL+HWP
Sbjct: 60 QEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 119
Query: 125 --------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRK 169
DT I +T A+EELVDEGL++ IG+SNF+ L++ + K
Sbjct: 120 KEFFPLDESGNVVPSDT--NILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 170 YEIVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARN 216
Y+ VNQ++ Y ++ L+ Y + +GI + AY+PL E L +
Sbjct: 178 YKPAVNQIECHPYLTQEK------LIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLED 231
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I ++ KT+AQV + + + + N+V IPK+ + I ENF + LS +D
Sbjct: 232 PRIKAIAAKHNKTTAQVLIRFPM-QRNLVVIPKSVTPERIAENFKVFDFELSSQD 285
>gb|AAA51714.1| (J05017) aldose reductase [Homo sapiens]
Length = 316
Score = 113 bits (280), Expect = 2e-24
Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 62/295 (21%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ +++G ID A Y +E VG AI
Sbjct: 12 KMPILGLGTWK---------SPPGQVTEAVKVAIDVGYRHIDCAHVY---QNENEVGVAI 59
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
+ REE+FIVSK+W T+ K A + + L Y+DLYL+HWP
Sbjct: 60 QEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 119
Query: 125 --------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRK 169
DT I +T A+EELVDEGL++ IG+SNF+ L++ + K
Sbjct: 120 KEFFPLDESGNVVPSDT--NILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 177
Query: 170 YEIVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARN 216
Y+ VNQ++ Y ++ L+ Y + +GI + AY+PL E L +
Sbjct: 178 YKPAVNQIECHPYLTQEK------LIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLED 231
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I ++ KT+AQV + + + + N+V IPK+ + I ENF + LS +D
Sbjct: 232 PRIKAIAAKHNKTTAQVLIRFPM-QRNLVVIPKSVTPERIAENFKVFDFELSSQD 285
>pdb|2ACQ| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+ And
Glucose-6-Phosphate >gi|576363|pdb|2ACR| Aldose
Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+
And Cacodylate >gi|442618|pdb|1ADS| Aldose Reductase
(E.C.1.1.1.21) Complex With Nadph >gi|576364|pdb|2ACS|
Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With
Nadp+ And Citrate >gi|1127255|pdb|1MAR| Aldose
Reductase (E.C.1.1.1.21)
Length = 315
Score = 113 bits (280), Expect = 2e-24
Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 62/295 (21%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ +++G ID A Y +E VG AI
Sbjct: 11 KMPILGLGTWK---------SPPGQVTEAVKVAIDVGYRHIDCAHVY---QNENEVGVAI 58
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
+ REE+FIVSK+W T+ K A + + L Y+DLYL+HWP
Sbjct: 59 QEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 118
Query: 125 --------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRK 169
DT I +T A+EELVDEGL++ IG+SNF+ L++ + K
Sbjct: 119 KEFFPLDESGNVVPSDT--NILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 176
Query: 170 YEIVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARN 216
Y+ VNQ++ Y ++ L+ Y + +GI + AY+PL E L +
Sbjct: 177 YKPAVNQIECHPYLTQEK------LIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLED 230
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I ++ KT+AQV + + + + N+V IPK+ + I ENF + LS +D
Sbjct: 231 PRIKAIAAKHNKTTAQVLIRFPM-QRNLVVIPKSVTPERIAENFKVFDFELSSQD 284
>pdb|1ABN| Aldose Reductase (E.C.1.1.1.21) Mutant With Cys 298 Replaced By
Ser (C298s) Complex With Nadph
Length = 315
Score = 113 bits (280), Expect = 2e-24
Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 62/295 (21%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ +++G ID A Y +E VG AI
Sbjct: 11 KMPILGLGTWK---------SPPGQVTEAVKVAIDVGYRHIDCAHVY---QNENEVGVAI 58
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
+ REE+FIVSK+W T+ K A + + L Y+DLYL+HWP
Sbjct: 59 QEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 118
Query: 125 --------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRK 169
DT I +T A+EELVDEGL++ IG+SNF+ L++ + K
Sbjct: 119 KEFFPLDESGNVVPSDT--NILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 176
Query: 170 YEIVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARN 216
Y+ VNQ++ Y ++ L+ Y + +GI + AY+PL E L +
Sbjct: 177 YKPAVNQIECHPYLTQEK------LIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLED 230
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I ++ KT+AQV + + + + N+V IPK+ + I ENF + LS +D
Sbjct: 231 PRIKAIAAKHNKTTAQVLIRFPM-QRNLVVIPKSVTPERIAENFKVFDFELSSQD 284
>pdb|1AZ1| Alrestatin Bound To C298aW219Y MUTANT HUMAN ALDOSE Reductase
>gi|2981776|pdb|1AZ2| Citrate Bound, C298aW219Y MUTANT
HUMAN ALDOSE REDUCTASE
Length = 315
Score = 113 bits (280), Expect = 2e-24
Identities = 92/295 (31%), Positives = 143/295 (48%), Gaps = 62/295 (21%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ +++G ID A Y +E VG AI
Sbjct: 11 KMPILGLGTWK---------SPPGQVTEAVKVAIDVGYRHIDCAHVY---QNENEVGVAI 58
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
+ REE+FIVSK+W T+ K A + + L Y+DLYL+HWP
Sbjct: 59 QEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 118
Query: 125 --------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRK 169
DT I +T A+EELVDEGL++ IG+SNF+ L++ + K
Sbjct: 119 KEFFPLDESGNVVPSDT--NILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 176
Query: 170 YEIVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARN 216
Y+ VNQ++ Y ++ L+ Y + +GI + AY+PL E L +
Sbjct: 177 YKPAVNQIECHPYLTQEK------LIQYCQSKGIVVTAYSPLGSPDRPYAKPEDPSLLED 230
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I ++ KT+AQV + + + + N+V IPK+ + I ENF + LS +D
Sbjct: 231 PRIKAIAAKHNKTTAQVLIRFPM-QRNLVVIPKSVTPERIAENFKVFDFELSSQD 284
>gb|AAB41556.1| (U13925) chalcone reductase [Medicago sativa subsp. sativa]
>gi|1096530|prf||2111449B chalcone reductase [Medicago
sativa]
Length = 312
Score = 113 bits (279), Expect = 3e-24
Identities = 82/285 (28%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +GMG+ PD++ +++ +A+ ++ G DTA YG SE+ +G+A+
Sbjct: 19 KMPVVGMGS-------APDFTCKKDTKDAIIEAIKQGYRHFDTAAAYG---SEQALGEAL 68
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ REE+F+ SK+W T A + S K L Y+DLYL+HWP +
Sbjct: 69 KEAIELGLVTREELFVTSKLWVTENHPHLVIPALQKSLKTLQLDYLDLYLIHWPLSSQPG 128
Query: 130 --------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++ ++EE + GL + IGVSNF ++ L E + V+
Sbjct: 129 KFSFPIDVADLLPFDVKGVWESMEESLKLGLTKAIGVSNFSVKKL----ENLLSVATVLP 184
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
V M+ ++ L ++ GI L A++PL KG + N L EI +GK+
Sbjct: 185 AVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKGASRGPNEVMENDMLKEIADAHGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQ++L +L +E+ V +PK+ +K+ + +N W L++ED E+
Sbjct: 245 VAQISLRWL-YEQGVTFVPKSYDKERMNQNLCIFDWSLTKEDHEK 288
>pir||S48850 chalcone reductase (EC 1.-.-.-) - alfalfa
>gi|563538|emb|CAA57784.1| (X82368) chalcone reductase
[Medicago sativa]
Length = 312
Score = 113 bits (279), Expect = 3e-24
Identities = 82/285 (28%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +GMG+ PD++ +++ +A+ ++ G DTA YG SE+ +G+A+
Sbjct: 19 KMPVVGMGS-------APDFTCKKDTKDAIIEAIKQGYRHFDTAAAYG---SEQALGEAL 68
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ REE+F+ SK+W T A + S K L Y+DLYL+HWP +
Sbjct: 69 KEAIELGLVTREELFVTSKLWVTENHPHLVIPALQKSLKTLQLDYLDLYLIHWPLSSQPG 128
Query: 130 --------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++ ++EE + GL + IGVSNF ++ L E + V+
Sbjct: 129 KFSFPIDVADLLPFDVKGVWESMEESLKLGLTKAIGVSNFSVKKL----ENLLSVATVLP 184
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
V M+ ++ L ++ GI L A++PL KG + N L EI +GK+
Sbjct: 185 AVNQVEMNLAWQQKKLREFCNANGIVLTAFSPLRKGASRGPNEVMENDMLKEIADAHGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQ++L +L +E+ V +PK+ +K+ + +N W L++ED E+
Sbjct: 245 VAQISLRWL-YEQGVTFVPKSYDKERMNQNLCIFDWSLTKEDHEK 288
>gb|AAC13358.1| (U89150) aldose reductase [Mus musculus]
Length = 316
Score = 112 bits (278), Expect = 4e-24
Identities = 90/293 (30%), Positives = 144/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++LG ID A+ Y +E+ VG A+
Sbjct: 12 KMPTLGLGTWK---------SPPGQVTEAVKVAIDLGYRHIDCAQVY---QNEKEVGVAL 59
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----G 125
+ R+++FIVSK+W T K A + + L Y+DLYL+HWP G
Sbjct: 60 QEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPG 119
Query: 126 DTWKKIE-------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ ++ +T A+E+LVDEGL++ IGVSNF+ L++ R + KY+
Sbjct: 120 PDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L++Y +GI + AY+PL E L +
Sbjct: 180 PAVNQIECHPYLTQEK------LIEYCHSKGIVVTAYSPLGSPDRPWGKPEDPSLLEDPR 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I +Y KT+AQV + + I + N+V IPK+ I EN + +S ED
Sbjct: 234 IKAIAAKYNKTTAQVLIRFPI-QRNLVVIPKSVTPVRIAENLKVFDFEVSSED 285
>sp|P45376|ALDR_MOUSE ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE)
>gi|662845|gb|AAA62176.1| (L39795) aldose reductase [Mus
musculus] >gi|881964|gb|AAA69958.1| (U29152) aldose
reductase [Mus musculus] >gi|4586552|dbj|BAA76413.1|
(AB016665) aldose reductase [Mus musculus]
>gi|4894207|gb|AAD32300.1| (U93231) aldose reductase
[Mus musculus]
Length = 316
Score = 112 bits (278), Expect = 4e-24
Identities = 90/293 (30%), Positives = 144/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++LG ID A+ Y +E+ VG A+
Sbjct: 12 KMPTLGLGTWK---------SPPGQVTEAVKVAIDLGYRHIDCAQVY---QNEKEVGVAL 59
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----G 125
+ R+++FIVSK+W T K A + + L Y+DLYL+HWP G
Sbjct: 60 QEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPG 119
Query: 126 DTWKKIE-------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ ++ +T A+E+LVDEGL++ IGVSNF+ L++ R + KY+
Sbjct: 120 PDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L++Y +GI + AY+PL E L +
Sbjct: 180 PAVNQIECHPYLTQEK------LIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPR 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I +Y KT+AQV + + I + N+V IPK+ I EN + +S ED
Sbjct: 234 IKAIAAKYNKTTAQVLIRFPI-QRNLVVIPKSVTPVRIAENLKVFDFEVSSED 285
>sp|P26690|6DCS_SOYBN NAD(P)H DEPENDENT 6'-DEOXYCHALCONE SYNTHASE >gi|99953|pir||S14222
chalcone reductase (EC 1.-.-.-) - soybean
>gi|18728|emb|CAA39261.1| (X55730) reductase [Glycine
max]
Length = 315
Score = 112 bits (277), Expect = 5e-24
Identities = 83/285 (29%), Positives = 147/285 (51%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
++ +GMG+ PD++ +++ EA+ ++ G DTA YG SE+ +G+A+
Sbjct: 20 RMPVVGMGS-------APDFTCKKDTKEAIIEAVKQGYRHFDTAAAYG---SEQALGEAL 69
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ +R+++F+ SK+W T A R S K L Y+DLYL+HWP +
Sbjct: 70 KEAIHLGLVSRQDLFVTSKLWVTENHPHLVLPALRKSLKTLQLEYLDLYLIHWPLSSQPG 129
Query: 130 ------KIEETL--------HALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++E+ L ++EE GL + IGVSNF ++ L+ ++ VV+
Sbjct: 130 KFSFPIEVEDLLPFDVKGVWESMEECQKLGLTKAIGVSNFSVKKLQNLL-SVATIRPVVD 188
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
QV+ +L ++ L ++ K GI + A++PL KG + N L EI + +GK+
Sbjct: 189 QVEMNL---AWQQKKLREFCKENGIIVTAFSPLRKGASRGPNEVMENDVLKEIAEAHGKS 245
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV+L +L +E+ V +PK+ +K+ + +N W L+ +D +
Sbjct: 246 IAQVSLRWL-YEQGVTFVPKSYDKERMNQNLHIFDWALTEQDHHK 289
>sp|P15122|ALDR_RABIT ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE)
>gi|537593|gb|AAA31160.1| (M32818) aldose reductase
[Oryctolagus cuniculus] >gi|559768|gb|AAA50833.1|
(U12316) aldose reductase [Oryctolagus cuniculus]
>gi|559973|gb|AAB60687.1| (U13694) aldose reductase
[Oryctolagus cuniculus]
Length = 316
Score = 112 bits (277), Expect = 5e-24
Identities = 92/293 (31%), Positives = 141/293 (47%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++LG ID A Y +E VG A+
Sbjct: 12 KMPILGLGTWK---------SPPGQVTEAVKTAIDLGYRHIDCAHVY---QNENEVGVAL 59
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----G 125
+ REE+FIVSK+W T K A + + L Y+DLYL+HWP G
Sbjct: 60 QEKLKEQVVKREELFIVSKLWCTSHDKSLVKGACQKTLNDLKLDYLDLYLIHWPTGFKHG 119
Query: 126 DTWKKIE-------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ ++ +T A+E LVDEGL++ IGVSNF+ L++ R + KY+
Sbjct: 120 SEYFPLDAAGNVIPSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIERILNKPGLKYK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L+ Y +GI + AY+PL E L +
Sbjct: 180 PAVNQIECHPYLTQEK------LIQYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPR 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I ++ KT+AQV + + + + N+V IPK+ I ENF + LS ED
Sbjct: 234 IKAIADKHKKTTAQVLIRFPM-QRNLVVIPKSVTPARIAENFQVFDFELSSED 285
>pir||S48849 chalcone reductase (EC 1.-.-.-) - alfalfa
>gi|563536|emb|CAA57783.1| (X82367) chalcone reductase
[Medicago sativa]
Length = 312
Score = 112 bits (277), Expect = 5e-24
Identities = 81/285 (28%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +GMG+ PD++ +++ +A+ ++ G DTA YG SE+ +G+A+
Sbjct: 19 KMPVVGMGS-------APDFTCKKDTKDAIIEAIKQGYRHFDTAAAYG---SEQALGEAL 68
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ R+E+F+ SK+W T A + S K L Y+DLYL+HWP +
Sbjct: 69 KEAIELGLVTRDELFVTSKLWVTENHPHLVIPALQKSLKTLQLDYLDLYLIHWPLSSQPG 128
Query: 130 --------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++ ++EE + GL + IGVSNF ++ L E + V+
Sbjct: 129 KFSFPIDVADLLPFDVKGVWESMEESLKLGLTKAIGVSNFSVKKL----ENLLSVATVLP 184
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
V M+ ++ L ++ GI L A++PL KG + N L EI +GK+
Sbjct: 185 AVNQVEMNLAWQQKKLREFCNAHGIVLTAFSPLRKGASRGPNEVMENDMLKEIADAHGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQ++L +L +E+ V +PK+ +K+ + +N W L++ED E+
Sbjct: 245 VAQISLRWL-YEQGVTFVPKSYDKERMNQNLRIFDWSLTKEDHEK 288
>pir||S48851 chalcone reductase (EC 1.-.-.-) - alfalfa
>gi|563540|emb|CAA57782.1| (X82366) chalcone reductase
[Medicago sativa]
Length = 312
Score = 112 bits (277), Expect = 5e-24
Identities = 81/285 (28%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +GMG+ PD++ +++ +A+ ++ G DTA YG SE+ +G+A+
Sbjct: 19 KMPVVGMGS-------APDFTCKKDTKDAIIEAIKQGYRHFDTAAAYG---SEQALGEAL 68
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ R+E+F+ SK+W T A + S K L Y+DLYL+HWP +
Sbjct: 69 KEAIELGLVTRDELFVTSKLWVTENHPHLVIPALQKSLKTLQLDYLDLYLIHWPLSSQPG 128
Query: 130 --------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++ ++EE + GL + IGVSNF ++ L E + V+
Sbjct: 129 KFTFPIDVADLLPFDVKGVWESMEESLKLGLTKAIGVSNFSVKKL----ENLLSVATVLP 184
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
V M+ ++ L ++ GI L A++PL KG + N L EI +GK+
Sbjct: 185 AVNQVEMNLAWQQKKLREFCNAHGIVLTAFSPLRKGASRGPNEVMENDMLKEIADAHGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQ++L +L +E+ V +PK+ +K+ + +N W L++ED E+
Sbjct: 245 VAQISLRWL-YEQGVTFVPKSYDKERMNQNLRIFDWSLTKEDHEK 288
>sp|P30863|YAFB_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN ASPU-MLTD INTERGENIC REGION
>gi|78516|pir||JS0715 hypothetical 29.4K protein (aspV
3' region) - Escherichia coli >gi|216645|dbj|BAA02170.1|
(D12650) ORF267 [Escherichia coli]
>gi|4902944|dbj|BAA77878.1| (D83536) Hypothetical 29.4
kd protein in aspU-dniR intergenic region (orf267).
[Escherichia coli]
Length = 267
Score = 111 bits (275), Expect = 9e-24
Identities = 79/261 (30%), Positives = 136/261 (51%), Gaps = 24/261 (9%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI- 77
+ A G+GT+ + KD I ++ LELG IDTA+ Y +E VG+AI
Sbjct: 3 IPAFGLGTFRL---------KDDVVISSVITALELGYRAIDTAQIYD---NEAAVGQAIA 50
Query: 78 -EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK-KIEET 134
G R E++I +K+W + + + + S ++L T Y+DL L+HWP + +EE
Sbjct: 51 ESGVPRHELYITTKIWIENLSKDKLIPSLKESLQKLRTDYVDLTLIHWPSPNDEVSVEEF 110
Query: 135 LHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS--LMDRTPEETGLL 192
+ AL E +GL R IG+SNF + L+ ++ A+ I NQ++ S L +R ++
Sbjct: 111 MQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRK-----VV 165
Query: 193 DYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASN 252
+ K+ GI + +Y L G +++ +A ++ T AQV L + + E V IP ++
Sbjct: 166 AWAKQHGIHITSYMTLAYGKALKDEVIAAYAAKHNATPAQVILAWAMGEGYSV-IPSSTK 224
Query: 253 KDHIKENFGAMGWRLSREDRE 273
+ +++ N A +L ED++
Sbjct: 225 RKNLESNLKAQNLQLDAEDKK 245
>pdb|2ACU| Aldose Reductase (E.C.1.1.1.21) Mutant With Tyr 48 Replaced By His
(Y48h) Complexed With Nadp+ And Citrate
Length = 315
Score = 111 bits (275), Expect = 9e-24
Identities = 91/295 (30%), Positives = 143/295 (47%), Gaps = 62/295 (21%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ +++G ID A + +E VG AI
Sbjct: 11 KMPILGLGTWK---------SPPGQVTEAVKVAIDVGYRHIDCAHVH---QNENEVGVAI 58
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
+ REE+FIVSK+W T+ K A + + L Y+DLYL+HWP
Sbjct: 59 QEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 118
Query: 125 --------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRK 169
DT I +T A+EELVDEGL++ IG+SNF+ L++ + K
Sbjct: 119 KEFFPLDESGNVVPSDT--NILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLK 176
Query: 170 YEIVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARN 216
Y+ VNQ++ Y ++ L+ Y + +GI + AY+PL E L +
Sbjct: 177 YKPAVNQIECHPYLTQEK------LIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLED 230
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I ++ KT+AQV + + + + N+V IPK+ + I ENF + LS +D
Sbjct: 231 PRIKAIAAKHNKTTAQVLIRFPM-QRNLVVIPKSVTPERIAENFKVFDFELSSQD 284
>gi|6753038 aldo-keto reductase family 1, member B1 (aldose reductase);
aldehyde reductase 1 [Mus musculus]
>gi|2117448|pir||I49484 aldehyde reductase (EC 1.1.1.21)
- mouse >gi|786001|dbj|BAA06980.1| (D32250) aldose
reductase [Mus musculus] >gi|1093491|prf||2104210A
aldo-ketoreductase [Mus musculus]
Length = 316
Score = 111 bits (275), Expect = 9e-24
Identities = 89/293 (30%), Positives = 144/293 (48%), Gaps = 58/293 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S + EA++ ++LG ID ++ Y +E+ VG A+
Sbjct: 12 KMPTLGLGTWK---------SPPGQVTEAVKVAIDLGYRHIDCSQVY---QNEKEVGVAL 59
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----G 125
+ R+++FIVSK+W T K A + + L Y+DLYL+HWP G
Sbjct: 60 QEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPG 119
Query: 126 DTWKKIE-------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYE 171
+ ++ +T A+E+LVDEGL++ IGVSNF+ L++ R + KY+
Sbjct: 120 PDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYK 179
Query: 172 IVVNQVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKC 218
VNQ++ Y ++ L++Y +GI + AY+PL E L +
Sbjct: 180 PAVNQIECHPYLTQEK------LIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPR 233
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I +Y KT+AQV + + I + N+V IPK+ I EN + +S ED
Sbjct: 234 IKAIAAKYNKTTAQVLIRFPI-QRNLVVIPKSVTPVRIAENLKVFDFEVSSED 285
>gb|AAF47812.1| (AE003479) CG12766 gene product [Drosophila melanogaster]
Length = 320
Score = 111 bits (275), Expect = 9e-24
Identities = 92/295 (31%), Positives = 144/295 (48%), Gaps = 51/295 (17%)
Query: 11 FKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSE 70
FK + IG+GT+ S + + A+ + +++G IDTA FYG +E
Sbjct: 9 FKHNDGTHIQGIGLGTFA---------STEGDCERAVLHAIDVGYRHIDTAYFYG---NE 56
Query: 71 ELVGKAI-----EG-FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHW 123
VG A+ EG RE+IFI +K+W E + A R + K +G Y+DLYL+HW
Sbjct: 57 AEVGAAVRKKIAEGVIKREDIFITTKLWCNFHEPERVEYACRKTLKNIGLDYVDLYLIHW 116
Query: 124 P-------------GDTWKKIE-------ETLHALEELVDEGLIRYIGVSNFDLELLRRS 163
P D ++E +T A+E+LVD GL + IGVSNF+ E L R
Sbjct: 117 PFSYKYRGDNELIPKDANGEVELVDIDYLDTWGAMEKLVDLGLTKSIGVSNFNEEQLTRL 176
Query: 164 QEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEK-------GILARN 216
A K + + NQ++ + ++ L+ K+ GI + A++PL + +
Sbjct: 177 L-ANCKIKPIHNQIE---VHPALDQKKLIALCKKNGILVTAFSPLGRHNAELRTPTFMYD 232
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ I +Y K+ AQV + Y+I E + +PK+SN I+ENF ++L ED
Sbjct: 233 GKVQAIADKYNKSIAQVVIRYVI-ELGTIPLPKSSNPKRIEENFNVFDFKLDAED 286
>gb|AAG09967.1|AF248037_2 (AF248037) aldose reductase [Streptococcus agalactiae]
Length = 280
Score = 111 bits (275), Expect = 9e-24
Identities = 81/256 (31%), Positives = 135/256 (52%), Gaps = 36/256 (14%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW I KD +ELG I+TA+ Y ++E+ VG I
Sbjct: 12 KIPTLGLGTWMIDNDRVAQVVKD---------AIELGYRHINTAQAY---NNEKGVGVGI 59
Query: 78 E--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEET 134
+ G RE +F+ +K+ H YESA K+ S + LG IDL ++H P WK+ ET
Sbjct: 60 KESGITRESLFVTTKIAAEHKDYESATKSIDQSLEALGLDCIDLMIIHSP-QPWKEWRET 118
Query: 135 -----------LHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMD 183
ALE+ G ++ IGVSNF + L+ + VNQ+ + +
Sbjct: 119 DKHFDQGNLEAWRALEDAQKSGKVKSIGVSNFLEKDLKNGH-----VKPAVNQI-LAHIG 172
Query: 184 RTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEEN 243
TP + L+DY + +GI + AY+P+ G ++ + ++ ++YG + AQ+ + YL+ + N
Sbjct: 173 NTPFD--LIDYCQSKGIQVEAYSPIAHGQALKSDGIQKMAEKYGVSVAQLCIQYLL-QLN 229
Query: 244 VVAIPKASNKDHIKEN 259
++ +PKAS+K+H++ N
Sbjct: 230 LIVLPKASSKEHLQSN 245
>dbj|BAB09734.1| (AB015476) aldo/keto reductase-like protein [Arabidopsis thaliana]
Length = 324
Score = 111 bits (274), Expect = 1e-23
Identities = 87/303 (28%), Positives = 144/303 (46%), Gaps = 45/303 (14%)
Query: 14 IGDDKVTAIGMGTWGIGGKEFPDY--SKDRESIEALRYGLELGINLIDTAEFYGA----G 67
+G V+ +G GTW G + Y S D + +A LE GINL DTA+ YG G
Sbjct: 1 MGPLSVSPMGFGTWAWGNQLLWGYQTSMDDQLQQAFELALENGINLFDTADSYGTGRLNG 60
Query: 68 HSEELVGKAIEGF-----NREEIFIVSK--VWPTHFGYESAKKAARASAKRLG-TYIDLY 119
SE L+GK I+ + E+ + +K +P A RAS RL + +
Sbjct: 61 QSERLLGKFIKESQGLKGKQNEVVVATKFAAYPWRLTSGQFVNACRASLDRLQIDQLGIG 120
Query: 120 LLHWPGDTWKKIEETL--HALEELVDEGLIRYIGVSNFDLELLRRSQEAM--RKYEIVVN 175
LHW ++ ++E + L ++ ++GL+R +GVSN+ + L + + + R +
Sbjct: 121 QLHWSTASYAPLQELVLWDGLVQMYEKGLVRAVGVSNYGPQQLVKIHDYLKTRGVPLCSA 180
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARN------------------- 216
QV++SL+ E+ + GI L++Y+PL G+L
Sbjct: 181 QVQFSLLSMGKEQLEIKSICDELGIRLISYSPLGLGMLTGKYSSSKLPTGPRSLLFRQIL 240
Query: 217 -------KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSR 269
L+EI K+ GKT QVA+N+ I + V IP + H+++N GA+GW+L+
Sbjct: 241 PGLEPLLLALSEIAKKRGKTMPQVAINWCIC-KGTVPIPGIKSVRHVEDNLGALGWKLTN 299
Query: 270 EDR 272
+++
Sbjct: 300 DEQ 302
>pir||A34406 aldehyde reductase (EC 1.1.1.21) - rabbit (fragment)
>gi|164757|gb|AAA31157.1| (J05048) aldose reductase (EC
1.1.1.21) [Oryctolagus cuniculus]
Length = 302
Score = 110 bits (273), Expect = 2e-23
Identities = 91/289 (31%), Positives = 139/289 (47%), Gaps = 58/289 (20%)
Query: 22 IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEG-- 79
+G+GTW S + EA++ ++LG ID A Y +E VG A++
Sbjct: 2 LGLGTWK---------SPPGQVTEAVKTAIDLGYRHIDCAHVY---QNENEVGVALQEKL 49
Query: 80 ----FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GDTWK 129
REE+FIVSK+W T K A + + L Y+DLYL+HWP G +
Sbjct: 50 KEQVVKREELFIVSKLWCTSHDKSLVKGACQKTLNDLKLDYLDLYLIHWPTGFKHGSEYF 109
Query: 130 KIE-------------ETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYEIVVN 175
++ +T A+E LVDEGL++ IGVSNF+ L++ R + KY+ VN
Sbjct: 110 PLDAAGNVIPSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIERILNKPGLKYKPAVN 169
Query: 176 QVK---YSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCLAEI 222
Q++ Y ++ L+ Y +GI + AY+PL E L + + I
Sbjct: 170 QIECHPYLTQEK------LIQYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAI 223
Query: 223 GKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
++ KT+AQV + + + + N+V IPK+ I ENF + LS ED
Sbjct: 224 ADKHKKTTAQVLIRFPM-QRNLVVIPKSVTPARIAENFQVFDFELSSED 271
>pir||S75444 hypothetical protein slr1503 - Synechocystis sp. (strain PCC 6803)
>gi|1653089|dbj|BAA18005.1| (D90911) hypothetical
protein [Synechocystis sp.]
Length = 330
Score = 110 bits (272), Expect = 2e-23
Identities = 90/296 (30%), Positives = 140/296 (46%), Gaps = 44/296 (14%)
Query: 21 AIGMGTWGIGGKEFPDY--SKDRESIEALRYGLELGINLIDTAEFYGAGH----SEELVG 74
A+G GTW G K Y + + E R + GI DT + YG G SE+L+G
Sbjct: 15 AMGCGTWAWGNKLLWGYQPAMNGELERVFRECVAAGITFFDTGDSYGTGRLQGQSEKLLG 74
Query: 75 K---AIEGFNREEIFIVSKV--WPTHFGYESAKKAARASAKRLGTYIDLYLLHWPGDTWK 129
+ A EG N+++I + +K+ +P ++ A AS +RL IDL LHW +
Sbjct: 75 QFSQAYEGLNQDKICLATKLAPYPWRLTPQAMVGAGMASQQRLQRPIDLVQLHWSTANYA 134
Query: 130 KIEET--LHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRK--YEIVVNQVKYSLMDRT 185
+E L L +L G + +G+SNF + L+++ + + IV QV+YSL+
Sbjct: 135 PWQEQPLLKGLVQLCQRGHAKALGLSNFGPKRLQKAYDFCQNEGVSIVSLQVQYSLLSTD 194
Query: 186 P-EETGLLDYMKREGITLMAYTPLEKGILARN---------------------------K 217
P + GL + ++ GI L+AY+PL G+L
Sbjct: 195 PVSKLGLKELCEQLGIKLIAYSPLTLGLLTGKYGPQGPFPPGIRGLLFRRLLPKIQPLLD 254
Query: 218 CLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
L I + KT AQVALN+ I + + IP A N +++N GA+GW+L R + +
Sbjct: 255 TLQAIAREREKTMAQVALNWCICQ-GTMPIPGAKNCQQVQDNLGALGWQLDRGEMD 309
>gb|AAB41555.1| (U13924) chalcone reductase [Medicago sativa subsp. sativa]
>gi|1096529|prf||2111449A chalcone reductase [Medicago
sativa]
Length = 312
Score = 109 bits (271), Expect = 3e-23
Identities = 79/285 (27%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +GMG+ PD++ +++ +A+ ++ G DTA YG SE+ +G+A+
Sbjct: 19 KMPVVGMGS-------APDFTCKKDTKDAIIEAIKQGYRHFDTAAAYG---SEQALGEAL 68
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ R+++F+ SK+W T A + S K L Y+DLYL+HWP +
Sbjct: 69 KEAIELGLVTRDDLFVTSKLWVTENHPHLVIPALQKSLKTLQLDYLDLYLIHWPLSSQPG 128
Query: 130 --------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++ ++EE + GL + IGVSNF ++ L E + V+
Sbjct: 129 KFSFPIDVADLLPFDVKGVWESMEESLKLGLTKAIGVSNFSVKKL----ENLLSVATVLP 184
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
V M+ ++ L ++ GI L A++P+ KG + N L EI +GK+
Sbjct: 185 AVNQVEMNLAWQQKKLREFCNAHGIVLTAFSPVRKGASRGPNEVMENDMLKEIADAHGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQ++L +L +E+ V +PK+ +K+ + +N W L++ED E+
Sbjct: 245 VAQISLRWL-YEQGVTFVPKSYDKERMNQNLRIFDWSLTKEDHEK 288
>dbj|BAB12273.1| (AB047854) aldehyde reductase [Acinetobacter sp. M-1]
Length = 268
Score = 109 bits (271), Expect = 3e-23
Identities = 73/262 (27%), Positives = 140/262 (52%), Gaps = 24/262 (9%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
++ G+GT+ + KD+ I++++ LE+G IDTA+ Y +E VG+AI
Sbjct: 2 RIPQFGLGTFRL---------KDQAVIDSVKTALEVGYRAIDTAQVY---ENEAAVGQAI 49
Query: 78 --EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK-KIEE 133
G R+++F+ +K+W +F + + + S ++L T +DL L+HWP I
Sbjct: 50 AESGVARQDLFLTTKIWVDNFAEDKFIPSLKDSLQKLRTDAVDLTLIHWPAPALGVSIPS 109
Query: 134 TLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS--LMDRTPEETGL 191
+ L E +GL + IG+SNF++ L +++ +++ I NQ++ S L +R L
Sbjct: 110 VMQLLLEAKQQGLTKQIGISNFNIALTQQAIDSIGIEHIATNQIELSPYLQNRN-----L 164
Query: 192 LDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKAS 251
++Y++ + I + +Y L G + ++ L EI ++ T+AQVAL + + + IP ++
Sbjct: 165 VNYLREQNIDVTSYMTLAYGKVLQDPTLIEIAAQHQATTAQVALAWAL-QNGFAVIPSST 223
Query: 252 NKDHIKENFGAMGWRLSREDRE 273
++++ N A LS E+ +
Sbjct: 224 KRENLISNLKAQDLTLSAEEMQ 245
>dbj|BAA12084.1| (D83718) polyketide reductase [Glycyrrhiza echinata]
Length = 319
Score = 109 bits (270), Expect = 4e-23
Identities = 85/285 (29%), Positives = 143/285 (49%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
+V IGMG+ PD++ +++ EA+ ++ G DTA YG SE +G+A+
Sbjct: 24 RVPVIGMGS-------APDFTCKKDTKEAIIEAIKQGYRHFDTAAAYG---SETALGEAL 73
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ REE+F+ SK+W T A R S + L Y+DLYL+HWP +
Sbjct: 74 KEARDLGLVTREELFVTSKLWVTENHPHLVIPALRKSLETLQLEYLDLYLIHWPLSSQPG 133
Query: 130 ------KIEETL--------HALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++E+ L ++EE + GL + IGVSNF ++ L+ ++ VN
Sbjct: 134 KFSFPIQVEDLLPFDVKGVWESMEECLKLGLTKAIGVSNFSVKKLQNLL-SVATIRPAVN 192
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
QV+ +L ++ L ++ GI L A++PL KG + N L I + +GK+
Sbjct: 193 QVEMNL---AWQQKKLREFCTANGIVLTAFSPLRKGASRGPNEVMENDMLKGIAEAHGKS 249
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV+L +L +E+ V + K+ +K+ + +N W L+ ED ++
Sbjct: 250 IAQVSLRWL-YEQGVTFVAKSYDKERMNQNLQIFDWELTTEDHQK 293
>pir||T38538 probable oxidoreductase - fission yeast (Schizosaccharomyces pombe)
>gi|2408060|emb|CAB16262.1| (Z99165) Aldo/keto reductase
family oxidoreductase [Schizosaccharomyces pombe]
Length = 275
Score = 109 bits (270), Expect = 4e-23
Identities = 83/235 (35%), Positives = 123/235 (52%), Gaps = 26/235 (11%)
Query: 51 LELGINLIDTAEFYGAGHSEELVGKAI------EGFNREEIFIVSKVWPTHFGYESAKKA 104
L+ G ID+A+ Y H+E G+AI G RE+I+ SK+ GY+S +
Sbjct: 37 LQCGYRHIDSAQMY---HNEADCGRAILKFMEETGTKREDIWFTSKLNDLS-GYKSTLSS 92
Query: 105 ARASAKRLGT-YIDLYLLHWP-GD---TWKKIEETLHALEELVDEGLIRYIGVSNFDLEL 159
AS K G YIDL+LLH P GD +WK ALE+ V+EG +R IGVSNF
Sbjct: 93 IDASVKACGLGYIDLFLLHSPYGDRIESWK-------ALEKGVEEGKLRAIGVSNFGPHH 145
Query: 160 LRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCL 219
++ ++ K VNQ++ + + ++DY + +GI L AY PL G NK L
Sbjct: 146 IQELLDSHPKIIPCVNQIE---LHPFCSQQKVVDYCESKGIQLAAYAPLVHGEKFGNKQL 202
Query: 220 AEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
I +Y K+ AQ+ + Y + + + +PK+S IKEN + +S+ED E+
Sbjct: 203 LAIASKYNKSEAQIMIRYCL-QRGFIVLPKSSTPRRIKENGDVFDFEISKEDMEK 256
>emb|CAB41997.1| (AJ131966) 3-dehydroecdysone 3beta-reductase [Spodoptera
littoralis]
Length = 345
Score = 109 bits (270), Expect = 4e-23
Identities = 86/288 (29%), Positives = 138/288 (47%), Gaps = 34/288 (11%)
Query: 12 KRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEE 71
K + D ++ AI +GT+ K SKD++ + ++LG DTA Y ++E
Sbjct: 26 KMLNDREMPAIALGTYLGFDKGGAVTSKDKQLRNVVMQAIDLGYRHFDTAAIY---NTEA 82
Query: 72 LVGKAI-----EG-FNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWP 124
VG+AI EG RE++F+ +K+W TH E A + + + G Y+DL+L+HWP
Sbjct: 83 EVGEAIRMKIDEGVIKREDVFLTTKLWNTHHKREQVAVAMKETLNKTGLDYVDLFLMHWP 142
Query: 125 -------GDTWKKIEETLHALEELVDEGLIRYIGVSNFD-LELLRRSQEAMRKYEIVVNQ 176
+ ET A EE+V G + IG+SNF+ L++ QE K + +
Sbjct: 143 IALNEDYSHSNTDYLETWRATEEMVKLGYTKSIGLSNFNKLQVATVLQECTIKPVALQIE 202
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYTPLEK----------GILARNKCLAEIGKRY 226
V ++ + L+ Y K EGI +M Y+P G + L + K+Y
Sbjct: 203 VHPQII-----QEDLITYAKDEGIIVMGYSPFGSLVKRFGMDLPGPKMDDPVLTSLAKKY 257
Query: 227 GKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
KT AQ+ L +L+ + VV IPK + + EN ++L E+ E+
Sbjct: 258 EKTPAQIVLRWLV-DRKVVPIPKTVSPKRLLENINIFDFKLKEEEIEK 304
>gb|AAF50039.1| (AE003544) CG6084 gene product [Drosophila melanogaster]
Length = 302
Score = 109 bits (269), Expect = 5e-23
Identities = 88/298 (29%), Positives = 134/298 (44%), Gaps = 66/298 (22%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
+V IG+GTWG S + EA++ ++ G ID A Y +E+ VG +
Sbjct: 13 EVPIIGLGTWG---------SPKGQVTEAVKVAIDAGYRHIDCAYVY---QNEDEVGDGV 60
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
E RE++FI SK+W T + K A + L Y+DLYL+HWP
Sbjct: 61 EAKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEG 120
Query: 126 --------------------DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQE 165
DTWK A+E+LV+EGL++ IGVSNF+ + R E
Sbjct: 121 CDLFPTDKDGKTLYSPVDYVDTWK-------AMEKLVEEGLVKSIGVSNFNRRQIERVLE 173
Query: 166 AMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEK----------GILAR 215
+ V NQ++ + L+D+ K + IT+ AY+PL ++
Sbjct: 174 -VATIPPVTNQIE---CHPYLTQKKLIDFCKSKDITITAYSPLGSPNRPWAKAGDPVILE 229
Query: 216 NKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
+ EI + KT Q+ + Y + N+V IPK+ KD I+ NF + L+ E+ E
Sbjct: 230 EAKIKEIAAKKKKTPGQILIRYQVQRANIV-IPKSVTKDRIESNFQVFDFELTPEEIE 286
>prf||2008147C protein RAKd [Rattus norvegicus]
Length = 321
Score = 109 bits (269), Expect = 5e-23
Identities = 89/289 (30%), Positives = 141/289 (47%), Gaps = 49/289 (16%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ A+G GT P+ +S+EA+ ++ G + IDTA Y EE +G+AI+
Sbjct: 15 IPALGFGT------SIPNEVPKSKSLEAVHLAIDAGYHHIDTASAY---QIEEEIGQAIQ 65
Query: 79 -----GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWP-----GDT 127
G RE++FI +K+W T F E K A S K L Y DLY++H+P GD
Sbjct: 66 SKIKAGVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDK 125
Query: 128 WKKIE-------------ETLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEIV 173
+ + +T LE+ D GL++ IGVSNF+ + L R + KY+ V
Sbjct: 126 YLPVPDNGKWLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLINKPGLKYKPV 185
Query: 174 VNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAEI 222
NQV+ L ++ LLDY K + I L+AY L +L + L ++
Sbjct: 186 CNQVECHLY---MNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLDDPVLCDV 242
Query: 223 GKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
K+ ++ A +AL YL+ E VV + ++ ++ ++EN ++L ED
Sbjct: 243 AKKNKRSPALIALRYLVQRE-VVPLAQSFKENEMRENLQVFDFQLHPED 290
>sp|Q46857|YQHE_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN METC-SUFI INTERGENIC REGION
Length = 275
Score = 109 bits (269), Expect = 5e-23
Identities = 89/280 (31%), Positives = 144/280 (50%), Gaps = 27/280 (9%)
Query: 5 MAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY 64
MA + K + + +G+G W + + E I A++ LE+G IDTA Y
Sbjct: 1 MANPTVIKLQDGNVMPQLGLGVW---------QASNEEVITAIQKALEVGYRSIDTAAAY 51
Query: 65 GAGHSEELVGKAIEG--FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLL 121
+EE VGKA++ NREE+FI +K+W + ++ ++A S K+L YIDLYL+
Sbjct: 52 ---KNEEGVGKALKNASVNREELFITTKLW--NDDHKRPREALLDSLKKLQLDYIDLYLM 106
Query: 122 HWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVK-YS 180
HWP E + EL EGLI+ IGV NF + L+R + V+NQ++ +
Sbjct: 107 HWPVPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDE-TGVTPVINQIELHP 165
Query: 181 LMDRTPEETGLLDYMKREGITLMAYTPLEKG--ILARNKCLAEIGKRYGKTSAQVALNYL 238
LM ++ L + I +++PL +G + K + ++ +YGKT AQ+ + +
Sbjct: 166 LM----QQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWH 221
Query: 239 IWEENVVAIPKASNKDHIKENFGAMGWRLSRED-RERAKL 277
+ + +V IPK+ I ENF +RL +++ E AKL
Sbjct: 222 L-DSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKL 260
>gi|7304879 aldo-keto reductase AKR1C13 [Mus musculus]
>gi|6407376|dbj|BAA86850.1| (AB027125) aldo-keto
reductase AKR1C13 [Mus musculus]
Length = 323
Score = 108 bits (268), Expect = 6e-23
Identities = 92/290 (31%), Positives = 142/290 (48%), Gaps = 50/290 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ A+G GT+ KE P +S+EA L++G +DTA Y EE +G+AI+
Sbjct: 16 IPALGFGTYK--PKEVPK----SKSLEAACLALDVGYLHVDTAYAYQV---EEEIGQAIQ 66
Query: 79 G------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
RE++FI +K+W T F E K A S K+L Y+DLY++H+P GD
Sbjct: 67 SKIKAGVVKREDLFITTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSGD 126
Query: 127 TWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEI 172
+ E T LEE D GL++ IGVSNF+ L R + KY+
Sbjct: 127 NDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKP 186
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAE 221
V NQV+ L + LLDY + + I L+AY L +L + L +
Sbjct: 187 VCNQVECHLY---LNQRKLLDYCESKDIVLVAYGALGTQRYKKWVDQNSPVLLNDPVLCD 243
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ K+ ++ A +AL YLI + +V + ++ ++ ++EN G++LS ED
Sbjct: 244 VAKKNKRSPALIALRYLI-QRGIVPLAQSFKENEMRENLQVFGFQLSPED 292
>pir||B75341 probable oxidoreductase - Deinococcus radiodurans (strain R1)
>gi|6459673|gb|AAF11444.1|AE002028_6 (AE002028)
oxidoreductase, putative [Deinococcus radiodurans]
Length = 327
Score = 108 bits (268), Expect = 6e-23
Identities = 89/270 (32%), Positives = 136/270 (49%), Gaps = 21/270 (7%)
Query: 15 GDDKVTAIGMGTWGIGGKEFPDYSKDRE-SIEALRYGLELGINLIDTAEFYGAGHSEELV 73
G+ +V +G G + G DRE S+ LR LG+NLIDTA+ YG SEEL+
Sbjct: 48 GELEVNRLGYGAMRVTGDGVWGDPADREGSLATLRALPGLGVNLIDTADSYGPAVSEELI 107
Query: 74 GKAIEGFNREEIFIVSK---------VWPTHFGYESAKKAARASAKRLGT-YIDLYLLHW 123
+A+ + + + +K VWP E + A+ S +RLG IDL+ LH
Sbjct: 108 REALHPY--PGLVVATKGGLTRTGPNVWPPCGRPEYLIQQAQISRRRLGVERIDLWQLH- 164
Query: 124 PGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMD 183
D +E A+ +L+D+G+IR++G+S ++E + + A + + + Q Y+L +
Sbjct: 165 RIDPQVPRDEQFGAIRQLLDDGVIRFVGLSEVNVEEI---EAARQVFPVATVQNLYNLTN 221
Query: 184 RTPEETGLLDYMKREGITLMAYTPLEKG-ILARNKCLAEIGKRYGKTSAQVALNYLIWEE 242
R E +LDY REGI + + PL G + A L E R G AQVAL +++
Sbjct: 222 RKSE--AVLDYCGREGIGFLPWYPLASGKLAAEGSVLTETAARLGAAPAQVALAWVLRRS 279
Query: 243 NV-VAIPKASNKDHIKENFGAMGWRLSRED 271
V + IP S H++EN A L+ ED
Sbjct: 280 PVMLPIPGTSKVKHLEENVAAASLTLTDED 309
>pir||H72307 oxidoreductase, aldo/keto reductase family - Thermotoga maritima
(strain MSB8) >gi|4981550|gb|AAD36088.1|AE001762_15
(AE001762) oxidoreductase, aldo/keto reductase family
[Thermotoga maritima]
Length = 333
Score = 108 bits (266), Expect = 1e-22
Identities = 95/305 (31%), Positives = 138/305 (45%), Gaps = 64/305 (20%)
Query: 18 KVTAIGMGTW--GIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
+V+AIG+G G K+ PD +E I+ +R +ELGIN DTAE YG +EELVG+
Sbjct: 14 EVSAIGLGCMRMSFGQKKLPDR---KEMIKLIRTAVELGINFFDTAEVYGPYTNEELVGE 70
Query: 76 AIEGFNREEIFIVSKVWPTHFGY-----------------ESAKKAARASAKRLGTYIDL 118
A+E F E + T FG+ E KKA S +RL
Sbjct: 71 ALEPFKGEVVI------ATKFGFELYEDGRPGWKGLNSNPEHIKKAVEGSLRRLRVEAID 124
Query: 119 YLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVK 178
L D IEE A++EL++EG +++ G+ E +RR+ + + V Q +
Sbjct: 125 ILYQHRVDPNVPIEEVAGAVKELIEEGKVKHFGLCEASAETIRRAHKVC---PVDVVQYE 181
Query: 179 YSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA------------------------ 214
YS+ R PEE LL + GI +AY+PL KG L
Sbjct: 182 YSMWWRKPEEE-LLPTCEELGIGFVAYSPLGKGFLTGAIGENSKFDEEDSRSRIPRFQKE 240
Query: 215 ---RNKCLAE----IGKRYGKTSAQVALNYLIWEEN-VVAIPKASNKDHIKENFGAMGWR 266
N L E I +R G T +Q+AL +L+ ++ +V IP + H+ EN G
Sbjct: 241 NLRENLALVELRKTIAERKGATPSQIALAWLLAQKPWIVPIPGTTKLSHLLENIGGAFVE 300
Query: 267 LSRED 271
L+ E+
Sbjct: 301 LTPEE 305
>gb|AAF42808.1|AF177041_1 (AF177041) aldo-keto reductase a [Mus musculus]
Length = 323
Score = 108 bits (266), Expect = 1e-22
Identities = 92/290 (31%), Positives = 141/290 (47%), Gaps = 50/290 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ A+G GT+ KE P +S+EA L++G +DTA Y EE +G+AI+
Sbjct: 16 IPALGFGTYK--PKEVPK----SKSLEAACLALDVGYRHVDTAYAYQV---EEEIGQAIQ 66
Query: 79 G------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
RE++FI +K+W F E K A S K L Y+DLYL+H+P GD
Sbjct: 67 SKIKAGVVKREDLFITTKLWCGCFRPELVKPALEKSLKSLQLDYVDLYLIHYPVPMKPGD 126
Query: 127 TWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEI 172
++E T LEE D GL++ IGVSNF+ L R + KY+
Sbjct: 127 NESPLDENGKFLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKP 186
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAE 221
V NQV+ L ++ LLDY K + I L+AY L +L + L +
Sbjct: 187 VCNQVECHLY---LNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCD 243
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ KR ++ A +AL YL ++ +V + ++ ++ ++EN ++LS ED
Sbjct: 244 VAKRNKRSPALIALRYL-FQRGIVPLAQSFKENEMRENLQVFEFQLSPED 292
>pir||T02543 aldehyde dehydrogenase homolog F13M22.27 - Arabidopsis thaliana
>gi|3236259|gb|AAC23647.1| (AC004684) putative alcohol
dehydrogenase [Arabidopsis thaliana]
Length = 290
Score = 107 bits (265), Expect = 1e-22
Identities = 88/287 (30%), Positives = 137/287 (47%), Gaps = 44/287 (15%)
Query: 8 VSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAG 67
++ FK K ++G+GTW + P D A+ +++G ID A+ YG
Sbjct: 5 ITFFKLNTGAKFPSVGLGTW----QASPGLVGD-----AVAAAVKIGYRHIDCAQIYG-- 53
Query: 68 HSEELVGKAIEGF------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYL 120
+E+ +G ++ RE++FI SK+W T + +A + K L Y+DLYL
Sbjct: 54 -NEKEIGAVLKKLFEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYL 112
Query: 121 LHWPGDTWK-------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAM 167
+HWP K I T A+E L D G R IGVSNF + L E +
Sbjct: 113 IHWPARIKKGSVGIKPENLLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLE-L 171
Query: 168 RKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLE-------KGILARNKCLA 220
+ VNQV+ R +T L ++ K +G+ L AY+PL K + +N L
Sbjct: 172 ARVPPAVNQVECHPSWR---QTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSDVLKNPILN 228
Query: 221 EIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRL 267
+ ++ GK+ AQVAL + + + V +PK++N+ IKENF W +
Sbjct: 229 MVAEKLGKSPAQVALRWGLQMGHSV-LPKSTNEGRIKENFNVFDWSI 274
>dbj|BAB04730.1| (AP001510) oxidoreductase [Bacillus halodurans]
Length = 297
Score = 107 bits (265), Expect = 1e-22
Identities = 91/289 (31%), Positives = 150/289 (51%), Gaps = 48/289 (16%)
Query: 16 DDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
D V+ +G G +G D +K R ++ + LELGIN +DTA+ Y G +E+ VGK
Sbjct: 10 DLHVSELGFGCMSLG----TDETKARRIMDEV---LELGINYLDTADLYNQGLNEQFVGK 62
Query: 76 AIEGFNREEIFIVSKV------------WPTHFGYESAKKAARASAKRLGT-YIDLYLLH 122
A++G R++I + +KV W Y K+A + S +RL T YIDLY LH
Sbjct: 63 ALKG-RRQDIILATKVGNRFEQGKEGWWWDPSKAY--IKEAVKDSLRRLQTDYIDLYQLH 119
Query: 123 WPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLM 182
G I+ET+ A EEL EG+IRY G+S+ +++ E +++ IV ++YS++
Sbjct: 120 -GGTIDDPIDETIEAFEELKQEGVIRYYGISSIRPNVIK---EYLKRSNIVSIMMQYSIL 175
Query: 183 DRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAE----IGKRYGKTSA------- 231
DR PEE ++ G++++ P+ +G+L+R + L E + RY +
Sbjct: 176 DRRPEE--WFPLIQEHGVSVVVRGPVARGLLSR-RPLPEGEGYLNYRYDELKLLRESLPT 232
Query: 232 -----QVALNYLIWEENVVAIPK-ASNKDHIKENFGAM-GWRLSREDRE 273
++AL Y + + V + AS+ D +K N A+ L+ E+R+
Sbjct: 233 DRPLHELALQYCLAHDVVATVAAGASSIDQVKANVQAVEATPLTAEERQ 281
>sp|Q50668|YM98_MYCTU HYPOTHETICAL 34.9 KDA PROTEIN RV2298 >gi|7447942|pir||F70733
hypothetical protein Rv2298 - Mycobacterium tuberculosis
(strain H37RV) >gi|1449322|emb|CAB00973.1| (Z77163)
hypothetical protein Rv2298 [Mycobacterium tuberculosis]
Length = 323
Score = 107 bits (264), Expect = 2e-22
Identities = 90/291 (30%), Positives = 136/291 (45%), Gaps = 36/291 (12%)
Query: 15 GDDKVTAIGMGTWGIGGKE--FPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEEL 72
G +V+ IG+GTW G +E + D + + ++ LG+ L DTAE YG G SE +
Sbjct: 8 GIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERI 67
Query: 73 VGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWPGDTWKKI 131
+G+A+ G +R E+ + SKV+P K RASA+RL I LY +H P
Sbjct: 68 LGEAL-GDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPD- 125
Query: 132 EETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGL 191
+ + +L+D G I GVSN+ L R++ A+ + +V NQV +SL E L
Sbjct: 126 SVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGR-PVVSNQVHFSLAHPDALE-DL 183
Query: 192 LDYMKREGITLMAYTPLEKGILARN-----------------------------KCLAEI 222
+ + + E ++AY+PL +G+L L I
Sbjct: 184 VPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATLRAI 243
Query: 223 GKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
AQVAL +LI VVAIP AS+ + ++ N A LS + R+
Sbjct: 244 AVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRD 294
>dbj|BAA13113.1| (D86558) polyketide reductase (GGPKR1) [Glycyrrhiza glabra]
Length = 316
Score = 107 bits (264), Expect = 2e-22
Identities = 82/285 (28%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
+V IGMG+ PD++ +++ EA+ ++ G DTA YG SE +G+A+
Sbjct: 21 RVPVIGMGS-------APDFTCKKDTKEAIIEAIKQGYRHFDTAAAYG---SETALGEAL 70
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ RE++F+ SK+W T A R S + L Y+DLYL+HWP +
Sbjct: 71 KEARDLGLVTREDLFVTSKLWVTENHPHLVVPALRKSLETLQLEYLDLYLIHWPLSSQPG 130
Query: 130 --------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++ ++EE + GL + IGVSNF ++ L+ ++ VN
Sbjct: 131 KFSFPIQAEDLLPFDVKGVWESMEESLKLGLTKAIGVSNFSVKKLQNLL-SVATIRPAVN 189
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
QV+ +L ++ L ++ GI L A++PL KG + N L I + +GK+
Sbjct: 190 QVEMNL---AWQQKKLREFCNANGIVLTAFSPLRKGASRGPNEVMENDMLKGIAEAHGKS 246
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV+L +L +E+ V + K+ +K+ + +N W L+ ED ++
Sbjct: 247 IAQVSLRWL-YEQGVTFVAKSYDKERMNQNLQIFDWELTTEDHQK 290
>dbj|BAA13114.1| (D86559) polyketide reductase (GGPKR2) [Glycyrrhiza glabra]
Length = 315
Score = 107 bits (264), Expect = 2e-22
Identities = 82/285 (28%), Positives = 140/285 (48%), Gaps = 43/285 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
+V IGMG+ PD++ +++ EA+ ++ G DTA YG SE +G+A+
Sbjct: 20 RVPVIGMGS-------APDFTCKKDTKEAIIEAIKQGYRHFDTAAAYG---SETALGEAL 69
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK- 129
+ RE++F+ SK+W T A R S + L Y+DLYL+HWP +
Sbjct: 70 KEARDLGLVTREDLFVTSKLWVTENHPHLVVPALRKSLETLQLEYLDLYLIHWPLSSQPG 129
Query: 130 --------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
++ ++EE + GL + IGVSNF ++ L+ ++ VN
Sbjct: 130 KFSFPIQAEDLLPFDVKGVWESMEESLKLGLTKAIGVSNFSVKKLQNLL-SVATIRPAVN 188
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------LARNKCLAEIGKRYGKT 229
QV+ +L ++ L ++ GI L A++PL KG + N L I + +GK+
Sbjct: 189 QVEMNL---AWQQKKLREFCNANGIVLTAFSPLRKGASRGPNEVMENDMLKGIAEAHGKS 245
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV+L +L +E+ V + K+ +K+ + +N W L+ ED ++
Sbjct: 246 IAQVSLRWL-YEQGVTFVAKSYDKERMNQNLQIFDWELTTEDHQK 289
>gi|7304877 aldo-keto reductase AKR1C12 [Mus musculus]
>gi|6407382|dbj|BAA86851.1| (AB027237) aldo-keto
reductase AKR1C12 [Mus musculus]
Length = 323
Score = 107 bits (264), Expect = 2e-22
Identities = 91/290 (31%), Positives = 140/290 (47%), Gaps = 50/290 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ A+G GT+ KE P +S+EA L++G +DTA Y EE +G+AI+
Sbjct: 16 IPALGFGTYK--PKEVPK----SKSLEAACLALDVGYRHVDTAYAYQV---EEEIGQAIQ 66
Query: 79 G------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
RE++F+ +K+W F E K A S K L Y+DLYL+H+P GD
Sbjct: 67 SKIKAGVVKREDLFVTTKLWCGCFRPELVKPALEKSLKSLQLDYVDLYLIHYPVPMKPGD 126
Query: 127 TWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEI 172
++E T LEE D GL++ IGVSNF+ L R KY+
Sbjct: 127 NESPLDENGKFLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNNPGLKYKP 186
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAE 221
V NQV+ L ++ LLDY K + I L+AY L +L + L +
Sbjct: 187 VCNQVECHLY---LNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCD 243
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ KR ++ A +AL YL ++ +V + ++ ++ ++EN ++LS ED
Sbjct: 244 VAKRNKRSPALIALRYL-FQRGIVPLAQSFKENEMRENLQVFEFQLSPED 292
>prf||2008147A protein RAKb [Rattus norvegicus]
Length = 318
Score = 106 bits (262), Expect = 3e-22
Identities = 90/290 (31%), Positives = 139/290 (47%), Gaps = 50/290 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ A+G GT+ P+ +S+EA ++ G IDTA Y EE +G+AI+
Sbjct: 11 IPALGFGTYK------PEKVPKSKSLEAAHLAIDAGYRHIDTAYAY---QIEEEIGQAIQ 61
Query: 79 G------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
RE++FI +K+W T F E K A S K L Y DLY++H+P GD
Sbjct: 62 SKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGD 121
Query: 127 TWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEI 172
+ E T LE+ D GL++ IGVSNF+ + L R + KY+
Sbjct: 122 NDFPVPEKGKSLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKGLERLLNKPGLKYKP 181
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAE 221
V NQV+ L ++ LLDY K + I L+AY L +L + L +
Sbjct: 182 VCNQVECHLY---LNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCD 238
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ K+ +T A +AL YL+ + VV + ++ ++ ++EN ++LS ED
Sbjct: 239 VAKKNKRTPALIALRYLV-QRGVVPLAQSFKENEMRENLQVFDFQLSPED 287
>pir||T45928 reductase-like protein - Arabidopsis thaliana
>gi|7630008|emb|CAB88350.1| (AL132960) reductase-like
protein [Arabidopsis thaliana]
Length = 315
Score = 105 bits (260), Expect = 5e-22
Identities = 86/284 (30%), Positives = 135/284 (47%), Gaps = 52/284 (18%)
Query: 18 KVTAIGMGTW----GIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELV 73
K+ ++G+GTW G+ G +A+ +++G ID A YG +E +
Sbjct: 15 KIPSVGLGTWQAAPGVVG-------------DAVAAAVKIGYQHIDCASRYG---NEIEI 58
Query: 74 GKAIEGF------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGD 126
GK ++ RE++FI SK+W T + A + + L Y+DLYL+HWP
Sbjct: 59 GKVLKKLFDDGVVKREKLFITSKIWLTDLDPPDVQDALNRTLQDLQLDYVDLYLMHWPVR 118
Query: 127 TWK-------------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV 173
K I T A+E LVD G R IGVSNF + L EA R
Sbjct: 119 LKKGTVDFKPENIMPIDIPSTWKAMEALVDSGKARAIGVSNFSTKKLSDLVEAAR-VPPA 177
Query: 174 VNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-------EKGILARNKCLAEIGKRY 226
VNQV+ + ++ L ++ K +GI L Y+PL K + ++ + I K
Sbjct: 178 VNQVE---CHPSWQQHKLHEFCKSKGIHLSGYSPLGSPGTTWVKADVLKSPVIEMIAKEI 234
Query: 227 GKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRE 270
GK+ AQ AL + + + + +PK++N+ I+ENF +GW + +E
Sbjct: 235 GKSPAQTALRWGLQMGHSI-LPKSTNEGRIRENFDVLGWSIPKE 277
>gb|AAK43116.1| Oxidoreductase [Sulfolobus solfataricus]
Length = 344
Score = 105 bits (259), Expect = 7e-22
Identities = 93/321 (28%), Positives = 157/321 (47%), Gaps = 71/321 (22%)
Query: 18 KVTAIGMGTWGIGGKEFPD----YSKDRES-IEALRYGLELGINLIDTAE-FYGA----- 66
KV+ + +GTW + + D Y D+E+ ++ L+ + G+N IDTA ++GA
Sbjct: 19 KVSQVAIGTWFLPRLQEKDELGIYKVDKETTLKILKRAYDEGVNFIDTANRYHGAMAPVD 78
Query: 67 ----GHSEELVGKAIEGFNREEIFIVSKVWPTHFGYESAKKAARA--------SAKRLGT 114
G++E +VG+ ++ +RE + I +KV + + + +R S KRLGT
Sbjct: 79 LPHVGNAERIVGEFLKTVDRESVVISTKVRGKMGDFVNGEGLSRKHILWQIKESLKRLGT 138
Query: 115 -YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFD----LELLRRSQEAMRK 169
YID+Y +HWP K+E TL L LV+ GL+ Y+GVSN +E L+ S E
Sbjct: 139 SYIDVYFIHWPDPDTPKLE-TLRTLNSLVNNGLVYYLGVSNHSAVDVMEFLQLS-ERHNL 196
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI---------------LA 214
+ +V Q KY++++R E+ + KR G+ +MAY+PL +G L+
Sbjct: 197 EKFIVMQEKYNMLERDIEKDKAI-IAKRFGLAIMAYSPLAQGFLTGKYVDKNGWKIEELS 255
Query: 215 RNKCLAEIGKRY-------------------GKTSAQVALNYLIWEE-----NVVAIPKA 250
R ++ KRY G T +Q+A+++L+ V+ + A
Sbjct: 256 RASITEDLKKRYFTEANLRILLGLKDVASELGITLSQLAISWLLKRGEQLGITVIPLIGA 315
Query: 251 SNKDHIKENFGAMGWRLSRED 271
S +H+++N A+ L R+D
Sbjct: 316 SKIEHLEDNLSALNINL-RDD 335
>pir||JQ2253 aldehyde reductase (EC 1.1.1.21), NADPH-dependent - bromegrass
>gi|167113|gb|AAA21751.1| (L12042) aldose
reductase-related protein [Bromus inermis]
Length = 320
Score = 104 bits (258), Expect = 9e-22
Identities = 81/278 (29%), Positives = 132/278 (47%), Gaps = 45/278 (16%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ A+G+GTW G S S++ E G +DTA YG E+ VGK ++
Sbjct: 24 IPAVGLGTWRAG-------SDTAHSVQTAI--TEAGYRHVDTAAEYGV---EKEVGKGLK 71
Query: 79 -----GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-------- 124
G +R+++F+ SK+W T + + A + K L Y+DLYL+HWP
Sbjct: 72 AAMEAGIDRKDLFVTSKLWCTDLVPDRVRPALEKTLKDLQLDYLDLYLIHWPFRLKDGAH 131
Query: 125 -----GDTWK-KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVK 178
G+ + +E +E LV +GL++ IGV N+ + L R ++ + V
Sbjct: 132 KPPEAGEVLEFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLQSAKIAPAVCQ--- 188
Query: 179 YSLMDRTP--EETGLLDYMKREGITLMAYTPL---EKGILARNKCLAEIGKRYGKTSAQV 233
M+ P + +L+ K+ GI AY+PL EK LA + + ++ + KT QV
Sbjct: 189 ---MEMHPGWKNDKILEACKKHGIHATAYSPLCSSEKN-LAHDPVVEKVANKLNKTPGQV 244
Query: 234 ALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ + + + + IPK+S + IKEN GW + ED
Sbjct: 245 LIKWAL-QRGTIVIPKSSKDERIKENIQVFGWEIPEED 281
>gb|AAD22264.1|AF133841_1 (AF133841) aldose reductase ALDRXV4 [Xerophyta viscosa]
Length = 319
Score = 104 bits (258), Expect = 9e-22
Identities = 83/296 (28%), Positives = 133/296 (44%), Gaps = 55/296 (18%)
Query: 6 AKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG 65
AK FK + + A+G+GTW G K A+ G G IDTA YG
Sbjct: 10 AKTQSFKLLSGHSIPAVGLGTWKSGDKA------GNAVYTAITEG---GYRHIDTAAQYG 60
Query: 66 AGHSEELVGKAIE-----GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLY 119
E VG A++ G NR+ +F+ SKVW E + A + + + L Y+DLY
Sbjct: 61 V---HEEVGNALQSALKAGINRKALFVTSKVWCEDLSPERVRPALKNTLEELQLDYLDLY 117
Query: 120 LLHWP---------------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFDLE 158
L+HWP G W++ +E+LV GL+R IG+SNF ++
Sbjct: 118 LIHWPIHLKKGAHMPPEAGEVLEFDIGGVWRE-------MEKLVKVGLVRDIGISNFTVK 170
Query: 159 LLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL---EKGILAR 215
L E + + + V M + + + ++ GI AY+PL E+ +L+
Sbjct: 171 KL----EKLLNFAEIKPSVCQMEMHPGWRKHKMFEICRKYGIHTTAYSPLGSSERDLLS- 225
Query: 216 NKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ + +I + K+ Q+ + + + + IPK++N + IKEN GW + ED
Sbjct: 226 DPTVLKIANKLNKSPGQLLVRWAV-QRGTSVIPKSTNPERIKENIQVFGWEIPAED 280
>gb|AAG15839.2|AF055910_1 (AF055910) NADPH-dependent mannose 6-phosphate reductase [Orobanche
ramosa]
Length = 310
Score = 104 bits (258), Expect = 9e-22
Identities = 92/300 (30%), Positives = 138/300 (45%), Gaps = 61/300 (20%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+G W GK+ + + +++G D A Y +E VG+A+
Sbjct: 10 KMPIIGLGVWRTEGKDLKNL---------IINAIKIGYRHFDCAADY---KNEAEVGEAL 57
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
E RE++FI +K+W + G+ +A S K+L Y+DLYL+H+P
Sbjct: 58 EEALQTGLVKREDLFITTKLWNSDHGH--VVEACTDSLKKLRLEYLDLYLVHFPVATKHT 115
Query: 126 -----------------DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMR 168
DT +E T HA+E+LV GL R IG+SN+D+ L R A
Sbjct: 116 GVGTTDSALGDDGILDIDTTISLETTWHAMEDLVSLGLARSIGISNYDI-FLTRDCLAYS 174
Query: 169 KYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIG----- 223
K + VNQ++ + L+ + ++ GI + A+TPL G LA + +
Sbjct: 175 KIKPAVNQIE---THPYFQRESLVKFCQKHGICVTAHTPL-GGALANTEWFGTVSCLDDP 230
Query: 224 -------KRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAK 276
K KT AQ+AL + I + N V IPK S +D + ENF + LS ED E K
Sbjct: 231 VIKGLTEKYKKKTVAQIALRWGI-QRNTVVIPKTSKQDRLIENFQVFDFELSNEDMELLK 289
>emb|CAC17786.1| (AJ245805) rhoB-crystallin [Lepidodactylus lugubris]
Length = 319
Score = 104 bits (258), Expect = 9e-22
Identities = 85/293 (29%), Positives = 138/293 (47%), Gaps = 55/293 (18%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
++ +G+GTW + + EA+++ ++LG ID A Y +E +G AI
Sbjct: 12 RMPILGLGTW---------QAPPGKVEEAIKHAIDLGYRHIDCAHLY---RNENEIGNAI 59
Query: 78 E------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----G 125
+ RE++FIVSK+W T K A + + L Y+DLYL+H+P G
Sbjct: 60 QQNIKEGAVKREDLFIVSKLWCTFHEKSQVKGACQRTLSALKLDYLDLYLIHFPMGFKAG 119
Query: 126 DTWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYE 171
D ++E T +E+LVD GL++ +G+SNF+ E + + + +Y
Sbjct: 120 DDLIPLDEHGKVIPSNTDIRDTWEGMEDLVDAGLVKAVGISNFNREQIEKILNKPGLRYI 179
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-------------EKGILARNKC 218
NQ++ +ET L+ Y + +GIT+ A++P L +
Sbjct: 180 PANNQIE--CHPYLTQET-LIKYCRSKGITVCAHSPFGSPGNPVSTLGKTRYTTLIEDPT 236
Query: 219 LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ +I +Y KTSAQV L + I E N IPK+ +KEN ++LS ED
Sbjct: 237 VKKIADKYNKTSAQVLLRFHI-ERNTPVIPKSDKPHRLKENLQVFDFKLSDED 288
>sp|P52898|DDBX_BOVIN DIHYDRODIOL DEHYDROGENASE 3 (PROSTAGLANDIN F SYNTHASE)
>gi|1339854|dbj|BAA08493.1| (D49542) cytosolic
dihydrodiol dehydrogenase 3 [Bos taurus]
>gi|1669605|dbj|BAA13690.1| (D88749) prostaglandin F
synthase [Bos taurus]
Length = 323
Score = 104 bits (257), Expect = 1e-21
Identities = 91/290 (31%), Positives = 133/290 (45%), Gaps = 50/290 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ +G GT+ P E++E ++ +E G ID+A Y +EE VG+AI
Sbjct: 16 IPVLGFGTFA------PREVPKSEALEVTKFAIEAGFRHIDSAHLY---QNEEQVGQAIR 66
Query: 79 G------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
RE+IF SK+W T E + A S L Y+DLY++H+P G+
Sbjct: 67 SKIADGTVKREDIFYTSKLWSTSLRPELVRPALEKSLNNLQLDYVDLYIIHFPVALKPGE 126
Query: 127 TWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEI 172
T +E T ALE+ D GL + IGVSNF+ + L + + KY+
Sbjct: 127 TLFPTDENGKPIFDSVDLCRTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKP 186
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAE 221
V NQV+ ++ LLD+ K I L+AY L L + L+
Sbjct: 187 VCNQVE---CHPYFNQSKLLDFCKSHDIVLVAYGALGSQRLKEWVNPNLPFLLEDPVLSA 243
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I K++ +T A VAL Y I + VV + K+ NK IKEN + L+ ED
Sbjct: 244 IAKKHRQTPALVALRYQI-QRGVVVLAKSYNKKRIKENIQVFDFELTPED 292
>gb|AAD32792.1|AC007661_29 (AC007661) putative alcohol dehydrogenase [Arabidopsis thaliana]
Length = 350
Score = 104 bits (257), Expect = 1e-21
Identities = 85/281 (30%), Positives = 134/281 (47%), Gaps = 46/281 (16%)
Query: 18 KVTAIGMGTW----GIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELV 73
K+ ++G+GTW G+ G A+ +++G ID A+ YG LV
Sbjct: 15 KIPSVGLGTWQADPGLVGN-------------AVDAAVKIGYRHIDCAQIYGNEKEIGLV 61
Query: 74 GKAI-EG--FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
K + +G REE+FI SK+W T+ + +A + + L Y+DLYL+HWP
Sbjct: 62 LKKLFDGGVVKREEMFITSKLWCTYHDPQEVPEALNRTLQDLQLDYVDLYLIHWPVSLKK 121
Query: 125 GDTWKK--------IEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQ 176
G T K I T A+E L D G R IGVSNF + L + + VNQ
Sbjct: 122 GSTGFKPENILPTDIPSTWKAMESLFDSGKARAIGVSNFSSKKL-ADLLVVARVPPAVNQ 180
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYTPLEK-------GILARNKCLAEIGKRYGKT 229
V+ + ++ L D+ K +G+ L Y+PL + +N L + ++ GKT
Sbjct: 181 VE---CHPSWQQNVLRDFCKSKGVHLSGYSPLGSPGTTWLTSDVLKNPILGGVAEKLGKT 237
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRE 270
AQVAL + + + +PK++++D IK+NF W + +
Sbjct: 238 PAQVALRWGL-QMGQSVLPKSTHEDRIKQNFDVFNWSIPED 277
>pir||H70671 probable oxidoreductase - Mycobacterium tuberculosis (strain H37RV)
>gi|1694860|emb|CAB05440.1| (Z83018) hypothetical
protein Rv2971 [Mycobacterium tuberculosis]
Length = 282
Score = 103 bits (255), Expect = 2e-21
Identities = 81/250 (32%), Positives = 119/250 (47%), Gaps = 15/250 (6%)
Query: 24 MGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI--EGFN 81
M G+G E D +R A+ LE+G LIDTA YG +E VG+AI G
Sbjct: 21 MPVLGLGVAELSDDETER----AVSAALEIGCRLIDTAYAYG---NEAAVGRAIAASGVA 73
Query: 82 REEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEE 140
REE+F+ +K+ G+ +++A RAS RLG Y+DLYL+HWP K + + +
Sbjct: 74 REELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQ 133
Query: 141 LVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGI 200
EG R IGVSNF E + + + VNQ++ + E L + +
Sbjct: 134 SRGEGHARSIGVSNFTAENIENLID-LTFVTPAVNQIELHPLLNQDE---LRKANAQHTV 189
Query: 201 TLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENF 260
+Y PL G L N + I Y KT AQV L + + N V + +++ + I NF
Sbjct: 190 VTQSYCPLALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVV-RSARPERIASNF 248
Query: 261 GAMGWRLSRE 270
+ L+ E
Sbjct: 249 DVFDFELAAE 258
>gi|9256562 aldo-keto reductase [Mus musculus] >gi|1698718|gb|AAB37274.1|
(U68535) aldo-keto reductase [Mus musculus]
Length = 301
Score = 103 bits (255), Expect = 2e-21
Identities = 81/287 (28%), Positives = 136/287 (47%), Gaps = 46/287 (16%)
Query: 17 DKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKA 76
+ + +G+GTW E D A++ + LG D A Y H+E VG
Sbjct: 2 ENIPTVGLGTWKASPGEVTD---------AVKLAINLGYRHFDCAYLY---HNESEVGMG 49
Query: 77 I-----EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
I EG RE++F+VSK+W T K A + + L Y+DLYL+HWP
Sbjct: 50 ISEKIKEGVVKREDLFVVSKLWCTCHKKSLVKTACTNTLEALNLDYLDLYLIHWPIGFKP 109
Query: 125 GDTWKKIE-------------ETLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKY 170
G+ ++ +T A+E+LV EGL++ +GVSNF+ E L R + +
Sbjct: 110 GEKDIPLDRNGKVIPSHTSFLDTWEAMEDLVFEGLVKNLGVSNFNHEQLERLLDKPGLRV 169
Query: 171 EIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKG----ILARNKCLAEIGKRY 226
+ NQ++ + L+D+ + +++ AY PL L + + +I K++
Sbjct: 170 RPITNQIE---CHPYLNQKKLIDFCHKRNVSVTAYRPLGGSGGGFHLMDDTVIRKIAKKH 226
Query: 227 GKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
GK+ AQ+ + + I + N++ IPK+ I+EN + L+ +D E
Sbjct: 227 GKSPAQILIRFQI-QRNLIVIPKSVTPSRIRENIQVFDFELTEKDME 272
>sp|P05980|PGFS_BOVIN PROSTAGLANDIN-F SYNTHASE 1 (PGF SYNTHASE 1) (PGF 1)
(PROSTAGLANDIN-D2 11 REDUCTASE 1) (PGFSI)
>gi|89727|pir||A28396 prostaglandin-F synthase (EC
1.1.1.188) - bovine >gi|163512|gb|AAA30694.1| (J03570)
lung prostaglandin F [Bos taurus]
>gi|228091|prf||1717138A prostaglandin F synthetase [Bos
taurus]
Length = 323
Score = 103 bits (254), Expect = 3e-21
Identities = 87/290 (30%), Positives = 135/290 (46%), Gaps = 50/290 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ +G GT+ P+ E++EA ++ +E+G +D+A Y +EE VG+AI
Sbjct: 16 IPVLGFGTYA------PEEVPKSEALEATKFAIEVGFRHVDSAHLY---QNEEQVGQAIR 66
Query: 79 G------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
RE+IF SK+W E + A S + L Y+DLY++H P G+
Sbjct: 67 SKIADGTVKREDIFYTSKLWCNSLQPELVRPALEKSLQNLQLDYVDLYIIHSPVSLKPGN 126
Query: 127 TWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEI 172
+ +E T ALE+ D GL + IGVSNF+ + L + + KY+
Sbjct: 127 KFVPKDESGKLIFDSVDLCHTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKP 186
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAE 221
V NQV+ ++ LL++ K I L+AY L +L + L
Sbjct: 187 VCNQVE---CHPYLNQSKLLEFCKSHDIVLVAYAALGAQLLSEWVNSNNPVLLEDPVLCA 243
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I K++ +T A VAL Y + + VV + K+ NK IKEN + L+ ED
Sbjct: 244 IAKKHKQTPALVALRYQV-QRGVVVLAKSFNKKRIKENMQVFDFELTPED 292
>sp|P52897|PGF2_BOVIN PROSTAGLANDIN-F SYNTHASE 2 (PGF SYNTHASE 2) (PGF 2)
(PROSTAGLANDIN-D2 11 REDUCTASE 2) (PGFSII)
>gi|11374576|pir||JH0575 prostaglandin-F synthase (EC
1.1.1.188) II, hepatic [validated] - bovine
>gi|163606|gb|AAA30730.1| (M86544) prostaglandin F
synthetase II [Bos taurus]
Length = 323
Score = 103 bits (254), Expect = 3e-21
Identities = 87/290 (30%), Positives = 135/290 (46%), Gaps = 50/290 (17%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ +G GT+ P+ E++EA ++ +E+G +D+A Y +EE VG+AI
Sbjct: 16 IPVLGFGTYA------PEEVPKSEALEATKFAIEVGFRHVDSAHLY---QNEEQVGQAIR 66
Query: 79 G------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
RE+IF SK+W E + A S + L Y+DLY++H P G+
Sbjct: 67 SKIADGTVKREDIFYTSKLWCNSLQPELVRPALEKSLQNLQLDYVDLYIIHSPVSLKPGN 126
Query: 127 TWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEI 172
+ +E T ALE+ D GL + IGVSNF+ + L + + KY+
Sbjct: 127 KFVPKDESGKLIFDSVDLCHTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKP 186
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAE 221
V NQV+ ++ LL++ K I L+AY L +L + L
Sbjct: 187 VCNQVE---CHPYLNQSKLLEFCKSHDIVLVAYAALGAQLLSEWVNSNNPVLLEDPVLCA 243
Query: 222 IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
I K++ +T A VAL Y + + VV + K+ NK IKEN + L+ ED
Sbjct: 244 IAKKHKQTPALVALRYQV-QRGVVVLAKSFNKKRIKENMQVFDFELTPED 292
>sp|P54569|YQKF_BACSU HYPOTHETICAL OXIDOREDUCTASE IN ANSR-BMRU INTERGENIC REGION
>gi|7447941|pir||H69966 conserved hypothetical protein
yqkF - Bacillus subtilis >gi|1303983|dbj|BAA12638.1|
(D84432) YqkF [Bacillus subtilis]
>gi|2634797|emb|CAB14294.1| (Z99116) similar to
hypothetical proteins [Bacillus subtilis]
Length = 306
Score = 103 bits (254), Expect = 3e-21
Identities = 88/300 (29%), Positives = 141/300 (46%), Gaps = 58/300 (19%)
Query: 16 DDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
D ++ +G+G +G ++ +++ L +ELGIN +DTA+ Y G +EE+VG
Sbjct: 10 DLDISEVGLGCMSLG-------TEKNKALSILDEAIELGINYLDTADLYDRGRNEEIVGD 62
Query: 76 AIEGFNREEIFIVSKV------------WPTHFGYESAKKAARASAKRLGT-YIDLYLLH 122
AI+ R +I + +K W Y K+A + S RL T YIDLY LH
Sbjct: 63 AIQN-RRHDIILATKAGNRWDDGSEGWYWDPSKAY--IKEAVKKSLTRLKTDYIDLYQLH 119
Query: 123 WPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLM 182
G I+ET+ A EEL EG+IRY G+S+ +++ E ++K IV +++SL
Sbjct: 120 -GGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIK---EYVKKSNIVSIMMQFSLF 175
Query: 183 DRTPEETGLLDYMKREGITLMAYTPLEKGILAR--------------------------N 216
DR PEE L ++ I+++A P+ KG+L
Sbjct: 176 DRRPEE--WLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQNGYLSYSFEELTNAR 233
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVA-IPKASNKDHIKENFGAMGWRLSREDRERA 275
K + E+ T + +L YL+ + V + I AS + ++EN A R E+ +A
Sbjct: 234 KAMEEVAPDLSMT--EKSLQYLLAQPAVASVITGASKIEQLRENIQAANARRLTEEEIKA 291
>pir||B82645 phenylacetaldehyde dehydrogenase XF1729 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9106797|gb|AAF84538.1|AE003996_7 (AE003996)
phenylacetaldehyde dehydrogenase [Xylella fastidiosa]
Length = 291
Score = 103 bits (254), Expect = 3e-21
Identities = 83/272 (30%), Positives = 132/272 (48%), Gaps = 21/272 (7%)
Query: 15 GDDKVTAIGMGTWGIGGKEFPDYSKDR-ESIEALRYGLELGINLIDTAEFYGAGHSEELV 73
GD V +G G I G + +D E+I L+ E+G++LIDTA+ YG SE+L+
Sbjct: 15 GDLTVNRLGFGAMRITGPDVWGEPEDHDEAIRVLKRLPEIGVDLIDTADSYGPFVSEQLI 74
Query: 74 GKAIEGFNREEIFIVSKV-----------WPTHFGYESAKKAARASAKRLG-TYIDLYLL 121
A+ + +I + WP ++ S +RL IDL+ L
Sbjct: 75 ADALHPYGGIKIATKGSLVRYPGNSTNPSWPVIGDPAYLRQCVYMSLRRLKLEQIDLWQL 134
Query: 122 HWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSL 181
H + E+ A+ E +DEGLIR+ G+S +E + +EA + + + Q +Y+L
Sbjct: 135 HRIDPKVPRAEQ-FGAIREFIDEGLIRHAGLSQVSVEAI---EEARKVFPVATVQNRYNL 190
Query: 182 MDRTPEETGLLDYMKREGITLMAYTPLEKGILAR-NKCLAEIGKRYGKTSAQVALNYLIW 240
DR E+ +LDY + GI + + PL G LA+ + + K G T+ Q+AL +L+
Sbjct: 191 ADRADED--VLDYCEANGIGFIPWFPLAAGDLAKPGGAVDALAKAKGATAGQIALAWLLK 248
Query: 241 EENVV-AIPKASNKDHIKENFGAMGWRLSRED 271
V+ IP S H++EN A LS E+
Sbjct: 249 RSPVILPIPGTSKVAHLEENVAAAAITLSDEE 280
>emb|CAA88322.1| (Z48360) aldose reductase [Hordeum vulgare]
Length = 320
Score = 102 bits (253), Expect = 4e-21
Identities = 80/277 (28%), Positives = 131/277 (46%), Gaps = 47/277 (16%)
Query: 21 AIGMGTWGIGGKEFPDYSKDRESIEALRYGL-ELGINLIDTAEFYGAGHSEELVGKAIE- 78
A+G+GTW G ++ ++R + E G +DTA YG E+ VGK ++
Sbjct: 26 AVGLGTWRAGS----------DTAHSVRTAITEAGYRHVDTAAEYGV---EKEVGKGLKA 72
Query: 79 ----GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP--------- 124
G +R+++F+ SK+W T+ E + A + K L YIDLY +HWP
Sbjct: 73 AMEAGIDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHM 132
Query: 125 ----GDTWK-KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKY 179
G+ + +E +E LV +GL++ IGV N+ + L R + + V
Sbjct: 133 PPEAGEVLEFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVCQ---- 188
Query: 180 SLMDRTP--EETGLLDYMKREGITLMAYTPL---EKGILARNKCLAEIGKRYGKTSAQVA 234
M+ P + + + K+ GI + AY+PL EK LA + + ++ + KT QV
Sbjct: 189 --MEMHPGWKNDKIFEACKKHGIHITAYSPLGSSEKN-LAHDPVVEKVANKLNKTPGQVL 245
Query: 235 LNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ + + + IPK+S + IKEN GW + ED
Sbjct: 246 IKWAL-QRGTSVIPKSSKDERIKENIQVFGWEIPEED 281
>gi|6322556 Yjr096wp [Saccharomyces cerevisiae]
>gi|1176340|sp|P47137|YJ66_YEAST PROBABLE OXIDOREDUCTASE
YJR096W >gi|1077006|pir||S57117 probable aldehyde
reductase (EC 1.1.1.-) YJR096w - yeast (Saccharomyces
cerevisiae) >gi|1015796|emb|CAA89626.1| (Z49596) ORF
YJR096w [Saccharomyces cerevisiae]
Length = 282
Score = 102 bits (253), Expect = 4e-21
Identities = 83/267 (31%), Positives = 127/267 (47%), Gaps = 33/267 (12%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +I +GT+ I + + E + G++ G DTA YG +E+ VG I
Sbjct: 13 KIPSIALGTYDIPRSQ---------TAEIVYEGVKCGYRHFDTAVLYG---NEKEVGDGI 60
Query: 78 --------EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG--TYIDLYLLHWPGDT 127
REEIF +K+W + GY+ AK A R + YIDL L+H P +
Sbjct: 61 IKWLNEDPGNHKREEIFYTTKLWNSQNGYKRAKAAIRQCLNEVSGLQYIDLLLIHSPLEG 120
Query: 128 WKKIEETLHALEELVDEGLIRYIGVSNFDL----ELLRRSQEAMRKYEIVVNQVKYSLMD 183
K ET A++E VDEGL++ IGVSN+ ELL + K++ VVNQ++ S
Sbjct: 121 SKLRLETWRAMQEAVDEGLVKSIGVSNYGKKHIDELLNWPE---LKHKPVVNQIEISPWI 177
Query: 184 RTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEEN 243
E L DY K +G+ + A+ PL G N L ++ K + QV + + + +
Sbjct: 178 MRQE---LADYCKSKGLVVEAFAPLCHGYKMTNPDLLKVCKEVDRNPGQVLIRWSL-QHG 233
Query: 244 VVAIPKASNKDHIKENFGAMGWRLSRE 270
+ +PK ++ N A + LS E
Sbjct: 234 YLPLPKTKTVKRLEGNLAAYNFELSDE 260
>emb|CAA11226.1| (AJ223291) chalcone reductase [Sesbania rostrata]
Length = 322
Score = 102 bits (253), Expect = 4e-21
Identities = 78/257 (30%), Positives = 131/257 (50%), Gaps = 39/257 (15%)
Query: 51 LELGINLIDTAEFYGAGHSEELVGKAI-----EGF--NREEIFIVSKVWPTHFGYESAKK 103
+++G D+A YG +EE +G A+ +G +R+E+FI SK W T ++
Sbjct: 43 IQVGYRHFDSASVYG---TEEAIGMAVSKAIEQGLIKSRDEVFITSKPWNTDAHHDLIVP 99
Query: 104 AARASAKRLG-TYIDLYLLHWPGDTWK----------------KIEETLHALEELVDEGL 146
A + + K+LG Y+DLYL+HWP IE T A+EE GL
Sbjct: 100 ALKTTLKKLGMEYVDLYLIHWPVRLRHDLENPVIFSKEDLLPFDIEGTWKAMEECYRLGL 159
Query: 147 IRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYT 206
+ IG+ N+ + L + E + VNQV+ M+ + ++ L ++ K++GI + A++
Sbjct: 160 AKSIGICNYGTKKLTKLLE-IATIPPAVNQVE---MNPSWQQGNLREFCKQKGIHVSAWS 215
Query: 207 PL-------EKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKEN 259
PL G + N+ L +I GKT AQVAL + ++++ A+ K+ NK+ +K+N
Sbjct: 216 PLGAYKIFWGSGAVMENQILQDIATAKGKTIAQVALRW-VYQQGSSAMAKSFNKERMKQN 274
Query: 260 FGAMGWRLSREDRERAK 276
+ LS E+ E+ K
Sbjct: 275 LEIFDFELSEEELEKIK 291
>gb|AAD23674.1|AC006841_3 (AC006841) putative NADPH dependent mannose 6-phosphate reductase
[Arabidopsis thaliana]
Length = 309
Score = 102 bits (253), Expect = 4e-21
Identities = 89/299 (29%), Positives = 144/299 (47%), Gaps = 60/299 (20%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+G W + +E D D +++G +D A Y +E VG+A+
Sbjct: 10 KMPIIGLGVWRMEKEELRDLIID---------AIKIGYRHLDCAANY---KNEAEVGEAL 57
Query: 78 -EGFN-----REEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
E F RE++FI +K+W + G+ +A + S K+L Y+DL+L+H P
Sbjct: 58 TEAFTTGLVKREDLFITTKLWSSDHGH--VIEACKDSLKKLQLDYLDLFLVHIPIATKHT 115
Query: 126 -----------------DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMR 168
DT +E T H +E+LV GL+R IG+SN+D+ L R A
Sbjct: 116 GIGTTDSALGDDGVLDIDTTISLETTWHDMEKLVSMGLVRSIGISNYDV-FLTRDCLAYS 174
Query: 169 KYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILAR-----------NK 217
K + VNQ++ + L+ + ++ GI + A+TPL G A +
Sbjct: 175 KIKPAVNQIE---THPYFQRDSLVKFCQKHGICVTAHTPL-GGATANAEWFGTVSCLDDP 230
Query: 218 CLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAK 276
L ++ ++Y +T AQ+ L + I + N V IPK S + ++ENF ++LS+ED E K
Sbjct: 231 VLKDVAEKYKQTVAQIVLRWGI-QRNTVVIPKTSKPERLEENFQVFDFQLSKEDMEVIK 288
>sp|P23901|ALDR_HORVU ALDOSE REDUCTASE (AR) (ALDEHYDE REDUCTASE) >gi|100562|pir||S15024
aldose reductase-related protein - barley
>gi|18891|emb|CAA40747.1| (X57526) aldose
reductase-related protein [Hordeum vulgare]
Length = 320
Score = 102 bits (252), Expect = 5e-21
Identities = 80/277 (28%), Positives = 131/277 (46%), Gaps = 47/277 (16%)
Query: 21 AIGMGTWGIGGKEFPDYSKDRESIEALRYGL-ELGINLIDTAEFYGAGHSEELVGKAIE- 78
A+G+GTW G ++ ++R + E G +DTA YG E+ VGK ++
Sbjct: 26 AVGLGTWRAGS----------DTAHSVRTAITEAGYRHVDTAAEYGV---EKEVGKGLKA 72
Query: 79 ----GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP--------- 124
G +R+++F+ SK+W T+ E + A + K L YIDLY +HWP
Sbjct: 73 AMEAGIDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHM 132
Query: 125 ----GDTWK-KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKY 179
G+ + +E +E LV +GL++ IGV N+ + L R + + V
Sbjct: 133 PPEAGEVLEFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVCQ---- 188
Query: 180 SLMDRTP--EETGLLDYMKREGITLMAYTPL---EKGILARNKCLAEIGKRYGKTSAQVA 234
M+ P + + + K+ GI + AY+PL EK LA + + ++ + KT QV
Sbjct: 189 --MEMHPGWKNDKIFEACKKHGIHVTAYSPLGSSEKN-LAHDPVVEKVANKLNKTPGQVL 245
Query: 235 LNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ + + + IPK+S + IKEN GW + ED
Sbjct: 246 IKWAL-QRGTSVIPKSSKDERIKENIQVFGWEIPEED 281
>emb|CAB72221.1| (AL138852) putative oxidoreductase [Streptomyces coelicolor A3(2)]
Length = 336
Score = 102 bits (252), Expect = 5e-21
Identities = 83/220 (37%), Positives = 118/220 (52%), Gaps = 30/220 (13%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEA------LRYGLELGINLIDTAEFYGAGHSEE 71
+V+AI +G G G PD + S+ A +R LE G+N +DTA Y AG+SEE
Sbjct: 12 EVSAIALGCMGFGE---PDRGGEPWSLGADPSRDIIRQALEGGVNFLDTANGYSAGNSEE 68
Query: 72 LVGKAIEGF-NREEIFIVSKVW----PTHFGYESAKKA----ARASAKRLGT-YIDLYLL 121
+VG+A++ F REE+ + +KVW P G ++KA AS KRLGT YIDLY +
Sbjct: 69 IVGQAVKDFARREEVVLSTKVWMRMRPGPNGAGLSRKAIFAELDASLKRLGTDYIDLYQI 128
Query: 122 H-WPGDTWKKIEETLHALEELVDEGLIRYIGVSN-----FDLELLRRSQEAMRKYEIVVN 175
H W DT IEETL AL ++V G +RY+G S+ F L ++ V
Sbjct: 129 HRWDYDT--PIEETLEALHDVVKSGKVRYLGASSMYAWQFAKALYLADLNGWTRF--VSM 184
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILAR 215
Q Y+L+ R E +L +GI ++ ++PL +G L R
Sbjct: 185 QDHYNLIHREAERE-MLPLCADQGIGVIPWSPLARGRLTR 223
>dbj|BAA93569.1| (AB035926) aldose reductase [Escherichia coli O157:H7]
Length = 206
Score = 102 bits (252), Expect = 5e-21
Identities = 71/221 (32%), Positives = 116/221 (52%), Gaps = 23/221 (10%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI- 77
+ A G+GT+ + KD I +++ LELG IDTA+ Y +E VG AI
Sbjct: 3 IPAFGLGTFRL---------KDDVVISSVKTALELGYRAIDTAQIYD---NEAAVGLAIA 50
Query: 78 -EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK-KIEET 134
G R E++I +K+W + + + + S ++L T Y+DL L+HWP + +EE
Sbjct: 51 ESGVPRHELYITTKIWIENLSKDKLIPSLKESLQKLRTDYVDLTLIHWPSPNDEVSVEEF 110
Query: 135 LHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS--LMDRTPEETGLL 192
+ AL E EGL R IG+SNF + L+ ++ A+ I NQ++ S L +R ++
Sbjct: 111 MQALLEAKKEGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRK-----VV 165
Query: 193 DYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQV 233
+ K+ GI + +Y L G +++ +A I ++ T AQV
Sbjct: 166 AWAKQHGIHITSYMTLAYGKALKDEVIARIAAKHNATPAQV 206
>sp|Q02198|MORA_PSEPU MORPHINE 6-DEHYDROGENASE (NALOXONE REDUCTASE)
>gi|1621507|gb|AAB17356.1| (M94775) morphine
dehydrogenase [Pseudomonas putida]
Length = 296
Score = 102 bits (251), Expect = 6e-21
Identities = 85/279 (30%), Positives = 139/279 (49%), Gaps = 41/279 (14%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ A+G+G + +E + A+ + G LIDTA Y ++E VG+ I
Sbjct: 15 KMPALGLGVFAASAEE---------TASAIASAISSGYRLIDTARSY---NNEAQVGEGI 62
Query: 78 E--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEET 134
G +R E+F+ +K++ +GYE A +A S RLG Y+DLYLLHWP W ++
Sbjct: 63 RNSGVDRAEMFVTTKLFNCDYGYERALRAFDESLGRLGLDYVDLYLLHWPTKDWNATIQS 122
Query: 135 LHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV--VNQVK-YSLMDRTPEETGL 191
A E+++ +G R IGV NF L + E + ++V VNQ++ + + P L
Sbjct: 123 WKAAEKILGDGRARAIGVCNF---LEDQLDELIAASDVVPAVNQIELHPYFAQKP----L 175
Query: 192 LDYMKREGITLMAYTPLEKGI-------------LARNKCLAEIGKRYGKTSAQVALNYL 238
L + GI A++P+ I + + I + +G+++AQV L +
Sbjct: 176 LAKNRALGIVTEAWSPIGGAINDGDGDNHGGRKHPLTDPVITTIAEAHGRSAAQVILRW- 234
Query: 239 IWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKL 277
++ +VVAIPK+ N + I +N + LS D E A+L
Sbjct: 235 HFQNDVVAIPKSVNPERIAKNIDVFDFALS--DAEMAQL 271
>gb|AAF54175.1| (AE003677) CG2767 gene product [Drosophila melanogaster]
Length = 329
Score = 102 bits (251), Expect = 6e-21
Identities = 91/298 (30%), Positives = 142/298 (47%), Gaps = 60/298 (20%)
Query: 17 DKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKA 76
+K+ IG+GTW + D E A+ LE G IDTA YG +E+ +G+
Sbjct: 13 EKMPVIGIGTW---------QASDEEIETAIDAALEAGYRHIDTAPVYG---NEKAIGRV 60
Query: 77 IEGF------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
++ + REE+FIV+KV P + + S + L Y+DLYL+H P
Sbjct: 61 LKRWLDAGKVKREELFIVTKVPPVSNRPHEVEPTIKKSLEDLQLDYVDLYLVHTPFTINI 120
Query: 125 --GDTWKKIEETLH-------------ALEELVDEGLIRYIGVSNFDLELLRRSQEAMRK 169
++K +E L A+E LV++GL + IGVSNF + + R + K
Sbjct: 121 NEDGSFKLDKEGLMEVDVTTNHAAIWVAMEALVEKGLTKSIGVSNFSKDQVARLLKNC-K 179
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-EKGILARNKC---------- 218
NQ+++ + ++ L+D+ K E IT+ AY+PL KGI N
Sbjct: 180 IRPANNQIEHHVY---LQQRDLVDFCKSENITVTAYSPLGSKGIAKFNAGAGIVRDLPDL 236
Query: 219 -----LAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ EI +GKT AQV L ++I + V AIPK++N +K+N + L+ E+
Sbjct: 237 MDIPEVKEIAASHGKTPAQVLLRWII-DTGVSAIPKSTNPARLKQNLDVFDFELTAEE 293
>gb|AAB53024.1| (U30873) OrfC [Bacillus subtilis]
Length = 269
Score = 101 bits (250), Expect = 8e-21
Identities = 75/206 (36%), Positives = 103/206 (49%), Gaps = 15/206 (7%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
KV IG G +GG D + +R L+ G+N IDTA YG G SEEL+G+ +
Sbjct: 13 KVKRIGFGANAVGGHNLFPNLNDETGKDLVRTALDGGVNFIDTAFIYGLGRSEELIGEVV 72
Query: 78 -EGFNREEIFIVSKVWPTHF--------GYESAKKAARASAKRLGT-YIDLYLLHWPGDT 127
E R E+ I +K E + S KRL T YIDLY +H+P D
Sbjct: 73 QERGVRNELIIATKGAHKEVDGSIELDNSREFLRSEVEKSLKRLKTDYIDLYYVHFP-DG 131
Query: 128 WKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPE 187
+ E L+EL DEG I+ IG SN D + L Q+ + V Q +YSL+ R E
Sbjct: 132 KTPLAEVAGTLKELKDEGKIKAIGASNLDYQQL---QDFNADGYLEVFQAEYSLIQRDAE 188
Query: 188 ETGLLDYMKREGITLMAYTPLEKGIL 213
+ LL Y +++GI+ + Y PL G+L
Sbjct: 189 KE-LLPYCEKQGISFIPYFPLASGLL 213
>sp|P46905|YCCK_BACSU HYPOTHETICAL OXIDOREDUCTASE IN NATB-RAPJ INTERGENIC REGION (ORFC)
>gi|7447928|pir||B69755 ion channel homolog yccK -
Bacillus subtilis >gi|2415728|dbj|BAA22238.1| (AB000617)
YccK [Bacillus subtilis] >gi|2632563|emb|CAB12071.1|
(Z99105) alternate gene name: yzaE~similar to ion
channel [Bacillus subtilis]
Length = 310
Score = 101 bits (250), Expect = 8e-21
Identities = 75/206 (36%), Positives = 103/206 (49%), Gaps = 15/206 (7%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
KV IG G +GG D + +R L+ G+N IDTA YG G SEEL+G+ +
Sbjct: 13 KVKRIGFGANAVGGHNLFPNLNDETGKDLVRTALDGGVNFIDTAFIYGLGRSEELIGEVV 72
Query: 78 -EGFNREEIFIVSKVWPTHF--------GYESAKKAARASAKRLGT-YIDLYLLHWPGDT 127
E R E+ I +K E + S KRL T YIDLY +H+P D
Sbjct: 73 QERGVRNELIIATKGAHKEVDGSIELDNSREFLRSEVEKSLKRLKTDYIDLYYVHFP-DG 131
Query: 128 WKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPE 187
+ E L+EL DEG I+ IG SN D + L Q+ + V Q +YSL+ R E
Sbjct: 132 KTPLAEVAGTLKELKDEGKIKAIGASNLDYQQL---QDFNADGYLEVFQAEYSLIQRDAE 188
Query: 188 ETGLLDYMKREGITLMAYTPLEKGIL 213
+ LL Y +++GI+ + Y PL G+L
Sbjct: 189 KE-LLPYCEKQGISFIPYFPLASGLL 213
>pir||T02542 aldehyde dehydrogenase homolog F13M22.26 - Arabidopsis thaliana
>gi|3236258|gb|AAC23646.1| (AC004684) putative alcohol
dehydrogenase [Arabidopsis thaliana]
Length = 294
Score = 101 bits (249), Expect = 1e-20
Identities = 85/280 (30%), Positives = 130/280 (46%), Gaps = 48/280 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG-----AGHSEEL 72
K+ +G+GT+ + A+ +++G ID A YG G ++L
Sbjct: 15 KLPCVGLGTYAMVAT-------------AIEQAIKIGYRHIDCASIYGNEKEIGGVLKKL 61
Query: 73 VGKAIEGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKK 130
+G +GF REE+FI SK+W E KA + + L Y+DLYL+HWP K+
Sbjct: 62 IG---DGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKE 118
Query: 131 -------------IEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQV 177
I T A+E L D G R IGVSNF + L R VNQV
Sbjct: 119 SLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVAR-VTPAVNQV 177
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPL---EKG----ILARNKCLAEIGKRYGKTS 230
+ ++ GL + K +G+ L Y+PL KG + +N + E+ ++ GKT+
Sbjct: 178 E---CHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTT 234
Query: 231 AQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRE 270
AQVAL + + + V +PK+S+ +KEN W + +
Sbjct: 235 AQVALRWGLQTGHSV-LPKSSSGARLKENLDVFDWSIPED 273
>pir||S61421 aldose reductase homolog - wild oat >gi|1155213|gb|AAC49138.1|
(U21747) aldose reductase-related protein [Avena fatua]
>gi|1587923|prf||2207360A aldose reductase [Avena fatua]
Length = 319
Score = 101 bits (248), Expect = 1e-20
Identities = 81/278 (29%), Positives = 130/278 (46%), Gaps = 45/278 (16%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE 78
+ A+G+GTW G S S++ E G +DTA YG E+ V K ++
Sbjct: 23 IPAVGLGTWRAG-------SDTAHSVQTAI--TEAGYRHVDTAAQYGI---EKEVDKGLK 70
Query: 79 -----GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-------- 124
G +R+++F+ SK+W T+ E A+ A + K L YIDLYL+HWP
Sbjct: 71 AAMEAGIDRKDLFVTSKIWRTNLAPERARPALENTLKDLQLDYIDLYLIHWPFRLKDGAH 130
Query: 125 -----GDTWK-KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVK 178
G+ + +E +E+LV +GL++ I V NF + L R + V
Sbjct: 131 QPPEAGEVLEFDMEGVWKEMEKLVKDGLVKDIDVCNFTVTKLNRLLRSANIPPAVCQ--- 187
Query: 179 YSLMDRTP--EETGLLDYMKREGITLMAYTPL---EKGILARNKCLAEIGKRYGKTSAQV 233
M+ P + + + K+ GI + AY+PL EK L + + ++ + KT QV
Sbjct: 188 ---MEMHPGWKNDKIFEACKKHGIHVTAYSPLGSSEKN-LVHDPVVEKVANKLNKTPGQV 243
Query: 234 ALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ + + + IPK+S + IKEN A GW + +D
Sbjct: 244 LIKWAL-QRGTSVIPKSSKDERIKENIQAFGWEIPEDD 280
>gb|AAD38635.1|AF145660_1 (AF145660) BcDNA.GH10614 [Drosophila melanogaster]
>gi|7292408|gb|AAF47813.1| (AE003479) BcDNA:GH10614 gene
product [Drosophila melanogaster]
Length = 316
Score = 101 bits (248), Expect = 1e-20
Identities = 89/301 (29%), Positives = 142/301 (46%), Gaps = 53/301 (17%)
Query: 6 AKVSDFKRIGDDKVTAIGMGTW-GIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFY 64
+K+ K ++ +IG+GT+ +GG + A + +++G IDTA FY
Sbjct: 3 SKIPYVKHNNGTQIQSIGLGTYTSLGG----------DCERATLHAIDVGYRHIDTAYFY 52
Query: 65 GAGHSEELVGKAIEG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YID 117
+E VG A++ RE+I I +K+W + + A R + + G Y+D
Sbjct: 53 ---ENENEVGAAVQRKIAEGVIKREDIHITTKLWCHFHEPKRVEYACRKTLQNFGLQYVD 109
Query: 118 LYLLHWP-------------GDTWKKIE-------ETLHALEELVDEGLIRYIGVSNFDL 157
LYL+HWP D ++E +T +E+LV+ GL + IGVSNF+
Sbjct: 110 LYLMHWPYSYVYRGDNEMMPTDAKGEVELNDIDYLDTWREMEKLVELGLTKSIGVSNFNS 169
Query: 158 ELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILAR-- 215
E L R A K + + NQ++ + L+ K+ I + AY PL + A
Sbjct: 170 EQLTRLL-ANCKIKPIHNQIE---CHPALNQKKLIALCKKNDIVVTAYCPLGRPNPAEKT 225
Query: 216 -----NKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRE 270
+ + IG +Y K++AQV L YLI E + +PK+SN I+ENF ++L E
Sbjct: 226 PNYIYDAKVQAIGDKYKKSTAQVVLRYLI-EIGTIPLPKSSNPKRIEENFQIFDFQLDAE 284
Query: 271 D 271
D
Sbjct: 285 D 285
>pir||T12582 auxin-induced protein - common sunflower >gi|2606077|gb|AAB84222.1|
(AF030301) auxin-induced protein [Helianthus annuus]
Length = 338
Score = 100 bits (247), Expect = 2e-20
Identities = 82/294 (27%), Positives = 144/294 (48%), Gaps = 46/294 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
+V+A G+G + P + + I + + + G+ +DT+++YG +E L+GKA+
Sbjct: 15 EVSAQGLGCMSMSAFYGPP-KPEPDMINLIHHAVNSGVTFVDTSDYYGPKTNEILLGKAL 73
Query: 78 EGFNREEIFIVSKV-------WPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK 129
+G R+++ + +K W + A AS KRL IDLY H DT
Sbjct: 74 KGGMRDKVELATKYGIKLSGSWEVKGDPAYVRAACEASLKRLYVDCIDLYYQH-RIDTRV 132
Query: 130 KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEET 189
IE T+ L+ELV+EG I+Y+G+S +RR+ + I Q+++SL R EE
Sbjct: 133 PIEITMGELKELVEEGKIKYVGLSEASASTIRRAHSV---HPITAIQLEWSLWSRDVEE- 188
Query: 190 GLLDYMKREGITLMAYTPLEKGILA---------------------------RNKCL--- 219
++ + GI ++AY+PL +G A NK L
Sbjct: 189 DIIPTCRELGIGIVAYSPLGRGFFASGSKMMEKLEDGDYRPNFPRFQPENLEHNKILYER 248
Query: 220 -AEIGKRYGKTSAQVALNYLIWEEN-VVAIPKASNKDHIKENFGAMGWRLSRED 271
+EI + G T++Q+AL ++ + N VV IP + +++++N GA+ +++ E+
Sbjct: 249 VSEIASKKGCTTSQLALAWVHHQGNDVVPIPGTTKIENLEQNIGALSVKITPEE 302
>gb|AAK43154.1| Oxidoreductase [Sulfolobus solfataricus]
Length = 368
Score = 100 bits (247), Expect = 2e-20
Identities = 89/302 (29%), Positives = 138/302 (45%), Gaps = 52/302 (17%)
Query: 3 WKMAKVSDFKRIGDD--KVTAIGMGTWGIG-GKEFPDYS----KDRESIEALRYGLELGI 55
+KM ++ + G+ KV+ +GTW + KE Y + ES + + ++LG+
Sbjct: 12 YKMCNKMEYMKFGNSGLKVSKFCLGTWHLPPSKERDSYGVYKVDEEESKKTIVKAIDLGV 71
Query: 56 NLIDTAEFYGA----------GHSEELVGKAIEGFNREEIFIVSKV---WPTHFGYESAK 102
N DTA Y G++E ++G+AI+G++RE + + +KV H E
Sbjct: 72 NFFDTANVYHGVMQGPDVFHVGNAERILGEAIKGYDRESLVLATKVRGKMAEHANGEGLS 131
Query: 103 KA-----ARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFD 156
+ R S KRL T YID+YL+H P D IEET+ +LV +G I YIG S FD
Sbjct: 132 RKHIMWQVRESLKRLNTDYIDIYLMHRP-DPDTPIEETMETFHDLVRQGKIHYIGESYFD 190
Query: 157 LELLRRSQEAMRKYEI--VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA 214
+ + + + + Q Y+ ++R E+ + K G+ +MAY PL +G+L
Sbjct: 191 PTDIPYLVKIAKDLHVPFIAMQEPYNFLERDIEKDKFI-LAKTYGLGIMAYIPLAQGVLT 249
Query: 215 RNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
GK T Y +P+ SN+ KENF + RE E
Sbjct: 250 --------GKYLNTTPDMSRATY---------VPEISNRYFTKENFEVL-----REFHEI 287
Query: 275 AK 276
AK
Sbjct: 288 AK 289
>dbj|BAA99542.1| (AB045829) 3alpha-hydroxysteroid dehydrogenase variant [Homo
sapiens]
Length = 323
Score = 100 bits (247), Expect = 2e-20
Identities = 86/285 (30%), Positives = 136/285 (47%), Gaps = 45/285 (15%)
Query: 24 MGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEG---- 79
M G G P+ ++R ++E + +E G ID+A Y ++EE VG AI
Sbjct: 16 MPVLGFGTYAPPEVPRNR-AVEVTKLAIEAGFRHIDSAYLY---NNEEQVGLAIRSKIAD 71
Query: 80 --FNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHW-----PGDTWKKI 131
RE+IF SK+W T F + + A +S K+L Y+DLYLLH+ PG+T
Sbjct: 72 GSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPK 131
Query: 132 EE-------------TLHALEELVDEGLIRYIGVSNFDLELLRR-SQEAMRKYEIVVNQV 177
+E T +E+ D GL + IGVSNF+ L + KY+ V NQV
Sbjct: 132 DENGKVIFDTVDLCATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQV 191
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLAEIGKRY 226
+ ++ LLD+ K + I L+A++ L +L + L + K++
Sbjct: 192 E---CHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKH 248
Query: 227 GKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+T A +AL Y + + VV + K+ N+ I+EN ++L+ ED
Sbjct: 249 KRTPALIALRYQL-QRGVVVLAKSYNEQRIRENIQVFEFQLTSED 292
>pir||T48732 2,5-diketo-D-gluconic acid reductase related protein [imported] -
Neurospora crassa >gi|7635782|emb|CAB88548.1| (AL353819)
2, 5-diketo-D-gluconic acid reductase related protein
[Neurospora crassa]
Length = 254
Score = 99.8 bits (245), Expect = 3e-20
Identities = 69/244 (28%), Positives = 122/244 (49%), Gaps = 18/244 (7%)
Query: 42 ESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI----------EGFNREEIFIVSKV 91
E+ A+R+ L G D+A++Y ++E G+AI G R+++ SK+
Sbjct: 6 ETTRAVRWALGAGYRGFDSAQWY---YNEREAGQAILSFLSSPENTAGLTRKDVHFTSKL 62
Query: 92 WPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYI 150
Y++ + + S K G YIDL+LLH P + + A+E+ V G ++
Sbjct: 63 RDNSTNYDAVRASISKSVKASGLGYIDLFLLHSPLGGREARLTSWKAVEDAVLAGEVKMA 122
Query: 151 GVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEK 210
GVSN+ ++ L A K + +VNQ++ + PE + + GI + AY PL +
Sbjct: 123 GVSNYGVKHLDEVMSAPFKIKPLVNQIECHPFNTQPEIRAACE---KYGIVIEAYAPLAR 179
Query: 211 GILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRE 270
G+ ++ L + K+YG T AQV + + + + V +PK++ K+ + EN + L+ E
Sbjct: 180 GMRMKHPVLTAVAKKYGVTPAQVLVRWSV-QHGFVTLPKSTKKERLVENADVGRFELAEE 238
Query: 271 DRER 274
D E+
Sbjct: 239 DMEK 242
>sp|Q09923|YAKC_SCHPO HYPOTHETICAL 37.7 KD PROTEIN C1F7.12 IN CHROMOSOME I
>gi|2130303|pir||S62584 probable oxidoreductase -
fission yeast (Schizosaccharomyces pombe)
>gi|7492782|pir||T38106 probable oxidoreductase -
fission yeast (Schizosaccharomyces pombe)
>gi|1067214|emb|CAA91959.1| (Z67998) putative
oxidoreductase [Schizosaccharomyces pombe]
Length = 340
Score = 99.5 bits (244), Expect = 4e-20
Identities = 89/309 (28%), Positives = 144/309 (45%), Gaps = 64/309 (20%)
Query: 12 KRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEE 71
++IG+D V AIG G G+ P + +++ L + +LG D+++ YG G +EE
Sbjct: 6 RKIGNDTVPAIGFGCMGLHAMYGPSSEEANQAV--LTHAADLGCTFWDSSDMYGFGANEE 63
Query: 72 LVGKAIEGFNR-EEIFIVSKVWPTHFGYES---------------AKKAARASAKRLGT- 114
+G+ + R +EIF+ +K FGYE +KA S KRLG
Sbjct: 64 CIGRWFKQTGRRKEIFLATK-----FGYEKNPETGELSLNNEPDYIEKALDLSLKRLGID 118
Query: 115 YIDLYLLH-WPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV 173
IDLY +H + G+T IE+ + AL++ V+ G IRYIG+S +RR A Y +
Sbjct: 119 CIDLYYVHRFSGET--PIEKIMGALKKCVEAGKIRYIGLSECSANTIRR---AAAVYPVS 173
Query: 174 VNQVKYSLMDRTPE--ETGLLDYMKREGITLMAYTPLEKGILA--------------RNK 217
QV+YS E E G++ + IT++ Y PL +G L R K
Sbjct: 174 AVQVEYSPFSLEIERPEIGVMKACRENNITIVCYAPLGRGFLTGAYKSPDDFPEGDFRRK 233
Query: 218 C-----------------LAEIGKRYGKTSAQVALNYLIWE-ENVVAIPKASNKDHIKEN 259
+ +I T Q++L +L+ + ++++ IP +++EN
Sbjct: 234 APRYQKENFYKNLELVTKIEKIATANNITPGQLSLAWLLAQGDDILPIPGTKRVKYLEEN 293
Query: 260 FGAMGWRLS 268
FGA+ +LS
Sbjct: 294 FGALKVKLS 302
>gb|AAD23673.1|AC006841_2 (AC006841) putative NADPH dependent mannose 6-phosphate reductase
[Arabidopsis thaliana]
Length = 309
Score = 99.1 bits (243), Expect = 5e-20
Identities = 89/300 (29%), Positives = 144/300 (47%), Gaps = 62/300 (20%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESI-EALRYGLELGINLIDTAEFYGAGHSEELVGKA 76
K+ +G+G W + ++E I + + +++G +D A Y +E VG A
Sbjct: 10 KMPIVGLGVWRM----------EKEGIRDLILNAIKIGYRHLDCAADY---RNETEVGDA 56
Query: 77 I-EGFN-----REEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG---- 125
+ E F RE++FI +K+W + G+ +A + S K+L Y+DL+L+H+P
Sbjct: 57 LTEAFKTGLVKREDLFITTKLWNSDHGH--VIEACKDSLKKLQLDYLDLFLVHFPVATKH 114
Query: 126 ------------------DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAM 167
DT +E T H +E+LV GL+R IG+SN+D+ L R A
Sbjct: 115 TGVGTTDSALGDDGVLDIDTTISLETTWHDMEKLVSMGLVRSIGISNYDV-FLTRDCLAY 173
Query: 168 RKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILAR-----------N 216
K + VNQ++ + L+ + ++ GI + A+TPL G A +
Sbjct: 174 SKIKPAVNQIE---THPYFQRDSLVKFCQKHGICVTAHTPL-GGATANAEWFGTVSCLDD 229
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAK 276
L ++ ++Y KT AQV L + I + VV IPK S ++ENF + LS+ED E K
Sbjct: 230 PVLKDVAEKYKKTVAQVVLRWGIQRKTVV-IPKTSKPARLEENFQVFDFELSKEDMEVIK 288
>pir||S30383 morphine 6-dehydrogenase (EC 1.1.1.218) - Pseudomonas putida
plasmid pMdh7.2
Length = 295
Score = 98.7 bits (242), Expect = 7e-20
Identities = 85/279 (30%), Positives = 139/279 (49%), Gaps = 42/279 (15%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ A+G+G + +E + A+ + G LIDTA Y ++E VG+ I
Sbjct: 15 KMPALGLGVFAASAEE---------TASAIASAISSGYRLIDTARSY---NNEAQVGEGI 62
Query: 78 EG-FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIEETL 135
+R E+F+ +K++ +GYE A +A S RLG Y+DLYLLHWP W ++
Sbjct: 63 RNSVDRAEMFVTTKLFNCDYGYERALRAFDESLGRLGLDYVDLYLLHWPTKDWNATIQSW 122
Query: 136 HALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV--VNQVK-YSLMDRTPEETGLL 192
A E+++ +G R IGV NF L + E + ++V VNQ++ + + P LL
Sbjct: 123 KAAEKILGDGRARAIGVCNF---LEDQLDELIAASDVVPAVNQIELHPYFAQKP----LL 175
Query: 193 DYMKREGITLMAYTPL--------------EKGILARNKCLAEIGKRYGKTSAQVALNYL 238
+ GI A++P+ K L + + I + +G+++AQV L +
Sbjct: 176 AKNRALGIVTEAWSPIGCHQRWQDGDNHGGRKHPLT-DPVITTIAEAHGRSAAQVILRW- 233
Query: 239 IWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKL 277
++ +VVAIPK+ N + I +N + LS D E A+L
Sbjct: 234 HFQNDVVAIPKSVNPERIAKNIDVFDFALS--DAEMAQL 270
>sp|P51652|PE2R_RAT 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE (20-ALPHA-HSD) (HSD1)
>gi|471152|dbj|BAA03317.1| (D14424)
20-alpha-hydroxysteroid dehydrogenase [Rattus
norvegicus] >gi|506415|gb|AAA40601.1| (L32601)
20-alpha-hydroxysteroid dehydrogenase [Rattus
norvegicus]
Length = 323
Score = 98.7 bits (242), Expect = 7e-20
Identities = 83/305 (27%), Positives = 142/305 (46%), Gaps = 50/305 (16%)
Query: 6 AKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG 65
+K+ + + +G GT+ + + ++S+E+ + +++G ID + Y
Sbjct: 3 SKIQKMELNDGHSIPVLGFGTYAT------EENLRKKSMESTKIAIDVGFRHIDCSHLY- 55
Query: 66 AGHSEELVGKAIEG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDL 118
+EE +G+AI RE+IF SK+W T E + + S ++L Y+DL
Sbjct: 56 --QNEEEIGQAIVSKIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENSLRKLNLDYVDL 113
Query: 119 YLLHWP-----GDTWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELL 160
YL+H+P GD +E T A+E+ D GL + IGVSNF+ L
Sbjct: 114 YLIHFPVSLKPGDELLPQDEHGNLILDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQL 173
Query: 161 RR-SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------- 208
+ + K+ V NQV+ L ++ LL Y K I L+AY L
Sbjct: 174 EKILNKPGLKHRPVCNQVECHLY---LNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINE 230
Query: 209 EKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLS 268
+ +L + L + K+Y +T A +AL Y + E +V + K+ N++ I+EN ++L+
Sbjct: 231 DTPVLLDDPILCTMAKKYKRTPALIALRYQL-ERGIVTLVKSFNEERIRENLQVFDFQLA 289
Query: 269 REDRE 273
+D E
Sbjct: 290 SDDME 294
>pir||S76143 probable aldehyde reductase (EC 1.1.1.-) - Synechocystis sp.
(strain PCC 6803) >gi|1653489|dbj|BAA18402.1| (D90914)
aldehyde reductase [Synechocystis sp.]
Length = 327
Score = 98.7 bits (242), Expect = 7e-20
Identities = 90/299 (30%), Positives = 139/299 (46%), Gaps = 55/299 (18%)
Query: 17 DKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKA 76
+++ A+G+GTW S + +A+ L+LG +D A YG +E +G
Sbjct: 19 EQIPALGLGTWK---------SSPQVVGQAVEQALDLGYRHLDCAAIYG---NEAEIGAT 66
Query: 77 IEG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE++I SK+W ++ A + + LG Y+DLYL+HWP
Sbjct: 67 LANAFTKGVVKREELWITSKLWSNAHHPDAVLPALEKTLQDLGLDYLDLYLIHWPVVIQP 126
Query: 125 -------GD-----TWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEI 172
GD T +E T ALE+ VD GL +IGVSNF L+ L +M +
Sbjct: 127 DVGFPESGDQLLPFTPASLEGTWQALEKAVDLGLCHHIGVSNFSLKKLEMVL-SMARIPP 185
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKG-------ILARNKCLAE---- 221
VNQV+ + +++ LL + + I L AY+PL G A K L +
Sbjct: 186 AVNQVE---LHPYLQQSDLLTFANSQNILLTAYSPLGSGDRPAAFQQAAEPKLLTDPVIN 242
Query: 222 -IGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAKLCV 279
I G ++AQV L + I + V IPK+ N + +++N A L+ D E AK+ +
Sbjct: 243 GIAAEQGCSAAQVLLAWAI-QRGTVTIPKSVNPERLEQNLRAADITLT--DSEMAKIAL 298
>pir||B65088 hypothetical protein b3012 - Escherichia coli (strain K-12)
>gi|882541|gb|AAA69179.1| (U28377) ORF_o236 [Escherichia
coli] >gi|1789387|gb|AAC76048.1| (AE000383) orf,
hypothetical protein [Escherichia coli K12]
Length = 236
Score = 98.3 bits (241), Expect = 9e-20
Identities = 78/232 (33%), Positives = 124/232 (52%), Gaps = 18/232 (7%)
Query: 53 LGINLIDTAEFYGAGHSEELVGKAIEG--FNREEIFIVSKVWPTHFGYESAKKAARASAK 110
+G IDTA Y +EE VGKA++ NREE+FI +K+W + ++ ++A S K
Sbjct: 1 MGYRSIDTAAAY---KNEEGVGKALKNASVNREELFITTKLW--NDDHKRPREALLDSLK 55
Query: 111 RLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRK 169
+L YIDLYL+HWP E + EL EGLI+ IGV NF + L+R +
Sbjct: 56 KLQLDYIDLYLMHWPVPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDE-TG 114
Query: 170 YEIVVNQVK-YSLMDRTPEETGLLDYMKREGITLMAYTPLEKG--ILARNKCLAEIGKRY 226
V+NQ++ + LM ++ L + I +++PL +G + K + ++ +Y
Sbjct: 115 VTPVINQIELHPLM----QQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKY 170
Query: 227 GKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED-RERAKL 277
GKT AQ+ + + + + +V IPK+ I ENF +RL +++ E AKL
Sbjct: 171 GKTPAQIVIRWHL-DSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKL 221
>gb|AAB97617.1| (U83687) NADPH-dependent mannose 6-phosphate reductase [Apium
graveolens]
Length = 309
Score = 98.3 bits (241), Expect = 9e-20
Identities = 88/300 (29%), Positives = 145/300 (48%), Gaps = 62/300 (20%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYG-LELGINLIDTAEFYGAGHSEELVGKA 76
K+ +G+G W + DR I+ L + LG D A Y +E VG+A
Sbjct: 10 KMPVLGLGVWRM----------DRNEIKNLLLSAINLGYRHFDCAADY---KNELEVGEA 56
Query: 77 I-EGFN-----REEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
E F+ RE++FI +K+W + G+ +A + S K+L Y+DLYL+H+P
Sbjct: 57 FKEAFDTDLVKREDLFITTKLWNSDHGH--VIEACKNSLKKLQLEYLDLYLIHFPMASKH 114
Query: 125 ---GDT---------WK-----KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAM 167
G T W+ +E T H +E+LV+ GL+R IG+SN+D+ L R +
Sbjct: 115 SGIGTTRSILDDEGVWEVDATISLEATWHEMEKLVEMGLVRSIGISNYDV-YLTRDILSY 173
Query: 168 RKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNK---------- 217
K + VNQ++ + L+ + ++ GI + A+TPL G LA +
Sbjct: 174 SKIKPAVNQIE---THPYFQRDSLIKFCQKYGIAITAHTPL-GGALANTERFGSVSCLDD 229
Query: 218 -CLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRERAK 276
L ++ ++ K+ AQ+ L + + + N + IPK+S ++EN + LS+ED E K
Sbjct: 230 PVLKKLSDKHNKSPAQIVLRWGV-QRNTIVIPKSSKTKRLEENINIFDFELSKEDMELIK 288
>pir||S72569 probable aldehyde reductase (EC 1.1.1.-) C35D10.6 - Caenorhabditis
elegans >gi|687885|gb|AAA62562.1| (U21324) similar to
aldose reductases [Caenorhabditis elegans]
Length = 287
Score = 97.5 bits (239), Expect = 2e-19
Identities = 77/275 (28%), Positives = 134/275 (48%), Gaps = 41/275 (14%)
Query: 22 IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE--- 78
IG+GTW + +E R+ I+A G + G IDTA+ Y ++E +G+ +E
Sbjct: 14 IGIGTWQVQKEEIL-----RQVIDA---GFKEGYRFIDTAQVY---NNEAKIGRILEKLL 62
Query: 79 ---GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKIE-- 132
G RE+I+I SK+ P++ G + A+++ S L Y+DL L+HWPG + K
Sbjct: 63 PANGLKREDIWITSKLAPSNAGVKKARESIEESLSNLKVEYLDLLLIHWPGSSLKSENPA 122
Query: 133 ------ETLHALEELVDEGLIRYIGVSNFD---LELLRRSQEAMRKYEIVVNQVKYSLMD 183
E+ + + E++ EG +R +GVSNF+ LE L++ + VNQV+Y
Sbjct: 123 NKKLRVESWNVMCEMMAEGKLRSVGVSNFEICHLEELKKDSNVVP----AVNQVEY---H 175
Query: 184 RTPEETGLLDYMKREGITLMAY----TPLEKGILARNKCLAEIGKRYGKTSAQVALNYLI 239
+ L+ Y I AY +P + L+ + E+ ++Y V L
Sbjct: 176 PHFHQDDLVKYCNENNIHFQAYSSLGSPTYRKQLSEEPLIKELAQKY-NVEIPVLLLGFA 234
Query: 240 WEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ + + +P+ +N +H+ NF +++ED +R
Sbjct: 235 YCQGISVLPRTTNPEHVATNFKVTKLAITQEDIDR 269
>gb|AAD30468.1| (AF124929) putative aldo/keto reductase family 2 enzyme
[Streptomyces clavuligerus]
Length = 344
Score = 97.5 bits (239), Expect = 2e-19
Identities = 95/312 (30%), Positives = 146/312 (46%), Gaps = 59/312 (18%)
Query: 12 KRIGDDKVTAIGMG---TWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGH 68
+ + D V+A G+G T G+ PD ++ +I A ++ G+ L+DTA+ G G
Sbjct: 23 RALRDLPVSAQGLGCLPTTDFYGR--PDRARATATIRA---AVDAGVTLLDTADVQGLGA 77
Query: 69 SEELVGKAIEGFNREEIFIVSKVWPTHFGYESA----------KKAARASAKRLGT-YID 117
EEL+G+A+ G R+E+ I +K ++ + A S +RLGT ID
Sbjct: 78 GEELLGRAVAG-RRDEVLIATKFGMVRSSDGASQGLCGEPSYVRAACERSLRRLGTDRID 136
Query: 118 LYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQV 177
LY HW D IEET+ A+ ELV EG +R +G+S LRR+ + + Q
Sbjct: 137 LYYQHWT-DPAVPIEETVGAVAELVREGKVRRLGLSEPSAATLRRADAV---HPVTAVQS 192
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------------------------- 212
++SL R E+ ++ + GI ++AY PL +G
Sbjct: 193 EWSLWSRGIEDE-VVPVCRELGIGIVAYAPLGRGFLTGTIRTTDDLGDEDFRRGQPRFSA 251
Query: 213 --LARNKCLAE----IGKRYGKTSAQVALNYLIWE-ENVVAIPKASNKDHIKENFGAMGW 265
LARN+ L + G T AQ+AL +L E+VV IP +N H+ +N A
Sbjct: 252 PALARNRSLLHRLRPVADGLGLTLAQLALAWLHHRGEDVVPIPGTANPAHLADNLAAASI 311
Query: 266 RLSREDRERAKL 277
RL +DR A++
Sbjct: 312 RL--DDRSLAEV 321
>pir||JC2330 luteal 20-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.-) - rat
Length = 323
Score = 97.1 bits (238), Expect = 2e-19
Identities = 82/305 (26%), Positives = 141/305 (45%), Gaps = 50/305 (16%)
Query: 6 AKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG 65
+K+ + + +G GT+ + + ++S+E+ + +++G ID + Y
Sbjct: 3 SKIQKMELNDGHSIPVLGFGTYAT------EENLRKKSMESTKIAIDVGFRHIDCSHLY- 55
Query: 66 AGHSEELVGKAIEG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDL 118
+EE +G+AI RE+IF SK+W T E + + S ++L Y+DL
Sbjct: 56 --QNEEEIGQAIVSKIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENSLRKLNLDYVDL 113
Query: 119 YLLHWP-----GDTWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELL 160
YL+H+P GD +E T A+E+ D GL + IGVSNF+ L
Sbjct: 114 YLIHFPVSLKPGDELLPQDEHGNLILDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQL 173
Query: 161 RR-SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------- 208
+ + K+ V NQV+ ++ LL Y K I L+AY L
Sbjct: 174 EKILNKPGLKHRPVCNQVE---CHHYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINE 230
Query: 209 EKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLS 268
+ +L + L + K+Y +T A +AL Y + E +V + K+ N++ I+EN ++L+
Sbjct: 231 DTPVLLDDPILCTMAKKYKRTPALIALRYQL-ERGIVTLVKSFNEERIRENLQVFDFQLA 289
Query: 269 REDRE 273
+D E
Sbjct: 290 SDDME 294
>gi|6324694 Similar to mammalian aldo/keto reductases; Gcy1p [Saccharomyces
cerevisiae] >gi|121087|sp|P14065|GCY_YEAST GCY PROTEIN
>gi|101162|pir||S22846 probable aldehyde reductase (EC
1.1.1.-) GCY1 - yeast (Saccharomyces cerevisiae)
>gi|3738|emb|CAA31615.1| (X13228) GCY protein (AA 1-312)
[Saccharomyces cerevisiae] >gi|1050812|emb|CAA62107.1|
(X90518) ORF O31567 [Saccharomyces cerevisiae]
>gi|1164965|emb|CAA64040.1| (X94335) YOR3269w
[Saccharomyces cerevisiae] >gi|1237092|emb|CAA65512.1|
(X96740) GCY protein [Saccharomyces cerevisiae]
>gi|1420317|emb|CAA99318.1| (Z75028) ORF YOR120w
[Saccharomyces cerevisiae]
Length = 312
Score = 96.3 bits (236), Expect = 4e-19
Identities = 86/289 (29%), Positives = 135/289 (45%), Gaps = 54/289 (18%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
++ IG+GTW SK+ ++ +A+ L+ G IDTA Y +E+ VG+AI
Sbjct: 19 QIPQIGLGTW---------QSKENDAYKAVLTALKDGYRHIDTAAIY---RNEDQVGQAI 66
Query: 78 E--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG--------- 125
+ G REEIF+ +K+W T + + A S KRLG Y+DLYL+HWP
Sbjct: 67 KDSGVPREEIFVTTKLWCTQ--HHEPEVALDQSLKRLGLDYVDLYLMHWPARLDPAYIKN 124
Query: 126 ------------------DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAM 167
W I +T ++EL G + +GVSNF + L+ +
Sbjct: 125 EDILSVPTKKDGSRAVDITNWNFI-KTWELMQELPKTGKTKAVGVSNFSINNLKDLLASQ 183
Query: 168 -RKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL--EKGILARNKCLAEIGK 224
K NQV+ + P++ L+++ K +GI + AY+PL L + + EI K
Sbjct: 184 GNKLTPAANQVE--IHPLLPQDE-LINFCKSKGIVVEAYSPLGSTDAPLLKEPVILEIAK 240
Query: 225 RYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
+ V +++ + + V +PK+ N D IK N + LS ED E
Sbjct: 241 KNNVQPGHVVISWHV-QRGYVVLPKSVNPDRIKTN--RKIFTLSTEDFE 286
>emb|CAB61562.2| (AL133171) putative aldo/keto reductase [Streptomyces coelicolor
A3(2)]
Length = 307
Score = 96.3 bits (236), Expect = 4e-19
Identities = 86/293 (29%), Positives = 138/293 (46%), Gaps = 43/293 (14%)
Query: 22 IGMGTWGIGGKEFPDYSKDRESIEAL-RYGLELGINLIDTAEFYGAGHSEELVGKAIEGF 80
+G T+G+ + +++ D + L R LE G+ DTA Y G SEE+VGKA+ F
Sbjct: 3 LGCMTYGVPDRGTHEWTLDEAASRPLIRQALEAGVTFFDTANVYSDGTSEEIVGKALADF 62
Query: 81 -NREEIFIVSKV----WPTHFGYESAKKAARA----SAKRLGT-YIDLYLLHWPGDTWKK 130
R++I + +KV P G ++KA S +RLGT Y+DLY +H D
Sbjct: 63 ARRDDIVLATKVNGRMRPGPNGAGLSRKAVMTEIDHSLRRLGTDYVDLYQIH-RFDPHTP 121
Query: 131 IEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKY---EIVVNQVKYSLMDRTPE 187
+EET+ AL +LV G +RYIG S+ + Q ++ + V Q Y+L+ R E
Sbjct: 122 VEETMEALHDLVKAGKVRYIGASSMYAWQFSKMQYTAERHGWTKFVSMQNHYNLVYR-EE 180
Query: 188 ETGLLDYMKREGITLMAYTPLEKGILARN--------------------------KCLAE 221
E +L +G+ ++ ++PL +G L R+ + +
Sbjct: 181 EREMLPLCADQGVGVLPWSPLARGRLTRDWDTATGRSATDTFGSTLYQEGDRAVVEAVTR 240
Query: 222 IGKRYGKTSAQVALNYLIWEENVVA-IPKASNKDHIKENFGAMGWRLSREDRE 273
I G A+VAL +L+ ++ V A I AS H+++ A+ LS + E
Sbjct: 241 IAGERGVPRARVALAWLLHQDTVTAPIVGASRPGHLEDAVAAVELTLSETEIE 293
>pir||T39901 probable aldo-keto reductase - fission yeast (Schizosaccharomyces
pombe) >gi|3873548|emb|CAA22125.1| (AL033534) putative
oxidoreductase; aldo-keto family [Schizosaccharomyces
pombe]
Length = 306
Score = 96.0 bits (235), Expect = 5e-19
Identities = 83/271 (30%), Positives = 142/271 (51%), Gaps = 21/271 (7%)
Query: 13 RIGDDKVTAIGMGTWGIGGKEFPDYSKDRES-IEALRYGLELGINLIDTAEFYGAGHSEE 71
++GD V +G G + G D KD+E+ I L+ EL IN IDTA+ YG SE
Sbjct: 19 KVGDMVVNRMGFGAMRVTGDGIWDEPKDKEACIATLKRLPELNINFIDTADSYGPEVSEN 78
Query: 72 LVGKAIEGFNREEIFIVSK-----VWPTHFGYESAKKAAR----ASAKRLGT-YIDLYLL 121
L+ +A+ + + + I +K P + A K R S +RLG IDL+ L
Sbjct: 79 LLREAL--YPYKGLIIATKGGLVRTGPNEWHPCGAPKFLRQEVLMSMRRLGVKQIDLWQL 136
Query: 122 HWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSL 181
H D ++ + + EGLIR++G+S ++ ++ EA + + +V Q ++L
Sbjct: 137 H-RIDPKVPRKDQFSEIAAMKKEGLIRHVGLSEVTVDDIK---EAEQYFPVVSVQNLFNL 192
Query: 182 MDRTPEETGLLDYMKREGITLMAYTPLEKGILAR-NKCLAEIGKRYGKTSAQVALNYLIW 240
++R E+ +L+Y +++GI + + PL G LA+ L + K ++++Q+AL++++
Sbjct: 193 VNRKNEK--VLEYCEQKGIAFIPWYPLASGALAKPGTILDAVSKDLDRSTSQIALSWVLQ 250
Query: 241 EENV-VAIPKASNKDHIKENFGAMGWRLSRE 270
V + IP S DH++EN A G +LS E
Sbjct: 251 RSPVMLPIPGTSKVDHLEENVKAAGIQLSSE 281
>dbj|BAB11959.1| (AB047396) glycerol dehydrogenase [Zygosaccharomyces rouxii]
Length = 310
Score = 96.0 bits (235), Expect = 5e-19
Identities = 85/290 (29%), Positives = 136/290 (46%), Gaps = 49/290 (16%)
Query: 1 MVWKMAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDT 60
MV S K + +G+GTW SK+ E +A+ L+ G ID
Sbjct: 1 MVTLQNSTSTLKLNTGQTIPQVGLGTWR---------SKENEGYKAVIEALKAGYRHIDG 51
Query: 61 AEFYGAGHSEELVGKAIE--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYID 117
A YG +E VGKAI+ G R EIF+ +K+W TH + ++A S +RLG Y+
Sbjct: 52 AAVYG---NEGEVGKAIQDSGVPRNEIFLTTKLWCTH--QRNPQEALDQSLQRLGLDYVG 106
Query: 118 LYLLHWP----------GDTWKKIE---------------ETLHALEELVDEGLIRYIGV 152
LYL+HWP G+ ++ E +T +++L++ G + IGV
Sbjct: 107 LYLVHWPVPLRTENIKDGNLFQFAEKPDGSKDVDLEWNFIKTWELMQKLLESGKTKAIGV 166
Query: 153 SNFDLELLRRSQEA-MRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL--E 209
SNF + L+ A K VNQV++ + P+E L+ Y +GI + AY+PL E
Sbjct: 167 SNFSVNNLKDLLAAPTTKVTPAVNQVEFHPL--LPQEE-LIQYCSEKGIVIEAYSPLGGE 223
Query: 210 KGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKEN 259
+ + + EI K G + V +++ + ++ +V +PK+ I N
Sbjct: 224 NAPILSDPTVQEIAKANGVEAGHVVISWAV-QKGLVTLPKSVTPSRIVGN 272
>sp|P25906|YDBC_ECOLI HYPOTHETICAL OXIDOREDUCTASE IN MAOC-ACPD INTERGENIC REGION
>gi|477201|pir||A48399 probable oxidoreductase (EC
1.-.-.-) ydbC - Escherichia coli
>gi|41830|emb|CAA44553.1| (X62680) ORF [Escherichia
coli] >gi|1742295|dbj|BAA15021.1| (D90779) IN2-2
protein. [Escherichia coli] >gi|1787674|gb|AAC74488.1|
(AE000238) putative dehydrogenase [Escherichia coli K12]
Length = 286
Score = 95.6 bits (234), Expect = 6e-19
Identities = 77/276 (27%), Positives = 135/276 (48%), Gaps = 27/276 (9%)
Query: 14 IGDDKVTAIGMGTWGIGGKEFPDYSKDRE-SIEALRYGLELGINLIDTAEFYGAGHSEEL 72
+G V +G G + G +DR +I LR L LG+N IDT++FYG + ++
Sbjct: 8 LGTKSVNRLGYGAMQLAGPGVFGPPRDRHVAITVLREALALGVNHIDTSDFYGPHVTNQI 67
Query: 73 VGKAIEGFNREEIFIVSKV---------WPTHFGYESAKKAARASAKRLG-TYIDLYLL- 121
+ +A+ ++ +++ IV+K+ W F +KA + + LG +D+ L
Sbjct: 68 IREALYPYS-DDLTIVTKIGARRGEDASWLPAFSPAELQKAVHDNLRNLGLDVLDVVNLR 126
Query: 122 ------HWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVN 175
H P + IE +L L E+ +GL+++IG+SN + EA + EIV
Sbjct: 127 VMMGDGHGPAE--GSIEASLTVLAEMQQQGLVKHIGLSNV---TPTQVAEARKIAEIVCV 181
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVAL 235
Q +Y++ R + ++D + +GI + + PL ++ L+++ G T QVAL
Sbjct: 182 QNEYNIAHRA--DDAMIDALAHDGIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVAL 239
Query: 236 NYLIWEE-NVVAIPKASNKDHIKENFGAMGWRLSRE 270
+L+ N++ IP S+ H++EN A LS E
Sbjct: 240 AWLLQRSPNILLIPGTSSVAHLRENMAAEKLHLSEE 275
>pir||T39169 probable oxidoreductase [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|2879854|emb|CAA16997.1|
(AL021815) probable oxidoreductase [Schizosaccharomyces
pombe]
Length = 325
Score = 94.8 bits (232), Expect = 1e-18
Identities = 88/289 (30%), Positives = 140/289 (47%), Gaps = 49/289 (16%)
Query: 4 KMAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEF 63
K A+ + F DK+ +IG+GTW G KD E+ A+ L+ G IDTA
Sbjct: 8 KNAREAYFTLPNGDKIPSIGLGTWRSG--------KD-ETKNAVCAALKAGYRHIDTAHI 58
Query: 64 YGAGHSEELVGKAIE--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYL 120
YG +E+ +G+ I G R +I++ SK+W A + + L YID YL
Sbjct: 59 YG---NEKEIGEGIRESGVPRTDIWVTSKLWCNAHRAGLVPLALEKTLQDLNLEYIDAYL 115
Query: 121 LHWP---------------GDTWKK---IEETLHALEELVDEGLIRYIGVSNFDLELLRR 162
+HWP G+ + IEET A+EEL++ G +RYIG+SNF+ E L R
Sbjct: 116 IHWPFALLSGPEELPRNEKGELIYEDVPIEETWQAMEELLETGKVRYIGISNFNNEYLDR 175
Query: 163 SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL---------EKGIL 213
+ + K + ++Q++ L P +T L+ K+ I + AY+PL + L
Sbjct: 176 VLK-IAKVKPTIHQME--LHPYLP-QTEYLEKHKKLQIHVSAYSPLANQNDAYNSDISKL 231
Query: 214 ARNKCLAEIGKRYGK--TSAQVALNYLIWEENVVAIPKASNKDHIKENF 260
+K L +I G+ T A +A+++ + + +PK+ N+ I NF
Sbjct: 232 IEHKTLVDIANARGEGITPANIAISWAV-KRGTSVLPKSVNESRIVSNF 279
>dbj|BAB11960.2| (AB047397) glycerol dehydrogenase [Zygosaccharomyces rouxii]
Length = 310
Score = 94.0 bits (230), Expect = 2e-18
Identities = 86/290 (29%), Positives = 135/290 (45%), Gaps = 49/290 (16%)
Query: 1 MVWKMAKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDT 60
MV S K + +G+GTW SK+ E +A+ L+ G ID
Sbjct: 1 MVTLQNSTSTLKLNTGQTIPQVGLGTWR---------SKENEGYKAVIEALKAGYRHIDG 51
Query: 61 AEFYGAGHSEELVGKAIE--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YID 117
A YG +E VGKAI+ G R EIF+ +K+W T + ++A S +RLG Y+D
Sbjct: 52 AAVYG---NEGEVGKAIQDSGVPRNEIFLTTKLWCTQ--QRNPQEALDQSLQRLGLDYVD 106
Query: 118 LYLLHWP----------GDTWKKIE---------------ETLHALEELVDEGLIRYIGV 152
LYL+HWP G+ ++ E +T +++L++ G + IGV
Sbjct: 107 LYLIHWPVPLRTENIKDGNLFQFAEKPDGSKDVDLEWNFIKTWELMQKLLESGKTKAIGV 166
Query: 153 SNFDLELLRRSQEA-MRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL--E 209
SNF + L+ A K VNQV+ L P+E L+ + K GI + AY+PL E
Sbjct: 167 SNFSVNNLKDLLAAPTTKVTPAVNQVE--LHPLLPQE-DLIKFGKENGIVIEAYSPLGGE 223
Query: 210 KGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKEN 259
+ + + EI K G + V +++ + ++ +V +PK+ I N
Sbjct: 224 NAPILSDPTVQEIAKANGVEAGHVVISWAV-QKGLVTLPKSVTPSRIVGN 272
>gi|5174391 aldo-keto reductase family 1, member A1 (aldehyde reductase) [Homo
sapiens] >gi|11422104|ref|XP_001394.1| aldo-keto
reductase family 1, member A1 (aldehyde reductase) [Homo
sapiens] >gi|113600|sp|P14550|ALDX_HUMAN ALCOHOL
DEHYDROGENASE [NADP+] (ALDEHYDE REDUCTASE)
>gi|105244|pir||A33851 alcohol dehydrogenase (NADP+) (EC
1.1.1.2) - human >gi|178481|gb|AAA51711.1| (J04794)
aldehyde reductase (EC 1.1.1.2) [Homo sapiens]
>gi|2707824|gb|AAB92369.1| (AF036683) aldehyde reductase
[Homo sapiens] >gi|6013149|gb|AAF01260.1|AF112485_1
(AF112485) aldehyde reductase [Homo sapiens]
Length = 325
Score = 93.6 bits (229), Expect = 2e-18
Identities = 80/295 (27%), Positives = 135/295 (45%), Gaps = 57/295 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+GTW K P K A++Y L +G ID A YG +E +G+A+
Sbjct: 13 KMPLIGLGTW----KSEPGQVK-----AAVKYALSVGYRHIDCAAIYG---NEPEIGEAL 60
Query: 78 E-------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE+F+ SK+W T E + A R + L Y+DLYL+HWP
Sbjct: 61 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120
Query: 125 GDT-------------WKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--RSQEAMRK 169
GD +ET ALE LV +GL++ +G+SNF+ + S ++R
Sbjct: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCL 219
+ V Y + L+ + + G+ + AY+PL ++ +L +
Sbjct: 181 AVLQVECHPYLAQNE------LIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVV 234
Query: 220 AEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ ++YG++ AQ+ L + + + V+ IPK+ I +N + S E+ ++
Sbjct: 235 LALAEKYGRSPAQILLRWQV-QRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQ 288
>sp|Q10494|YDG7_SCHPO PROBABLE OXIDOREDUCTASE C26F1.07 IN CHROMOSOME I
>gi|7492783|pir||T38413 probable oxidoreductase -
fission yeast (Schizosaccharomyces pombe)
>gi|1314176|emb|CAA97364.1| (Z73100) probable
oxidoreductase (EC 1.-.-.-) [Schizosaccharomyces pombe]
Length = 321
Score = 93.6 bits (229), Expect = 2e-18
Identities = 86/288 (29%), Positives = 144/288 (49%), Gaps = 51/288 (17%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ +G+GTW S+ ++ A++ L+ G ID A YG +E+ VG I
Sbjct: 23 KIPGLGLGTWR---------SEPNQTKNAVKTALQYGYRHIDAAAIYG---NEDEVGDGI 70
Query: 78 E--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------GDTW 128
+ G R++I++ SK+W E+ KA + K L Y+D YL+HWP D +
Sbjct: 71 KESGVPRKDIWVTSKLWCNAHAPEAVPKALEKTLKDLKLDYLDEYLIHWPVSFKTGEDKF 130
Query: 129 KK------------IEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQ 176
K IEET A+E+L++ G +R+IG+SNF+ L R + + K + V+Q
Sbjct: 131 PKDKDGNLIYEKNPIEETWKAMEKLLETGKVRHIGLSNFNDTNLERILK-VAKVKPAVHQ 189
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYTPL-------EKGI--LARNKCLAEIGKRYG 227
++ + +T ++ K+ GI + AY+P E I L ++ + +I K G
Sbjct: 190 ME---LHPFLPQTEFVEKHKKLGIHVTAYSPFGNQNTIYESKIPKLIEHETIQKIAKSKG 246
Query: 228 K--TSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
+ T A +A+++ I V IPK+ N+ IK NF + L++ED +
Sbjct: 247 EGVTGATIAVSWAITRGTSV-IPKSVNEQRIKSNFKYI--PLTKEDMD 291
>pdb|2ALR| Aldehyde Reductase
Length = 324
Score = 93.6 bits (229), Expect = 2e-18
Identities = 80/295 (27%), Positives = 135/295 (45%), Gaps = 57/295 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+GTW K P K A++Y L +G ID A YG +E +G+A+
Sbjct: 12 KMPLIGLGTW----KSEPGQVK-----AAVKYALSVGYRHIDCAAIYG---NEPEIGEAL 59
Query: 78 E-------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE+F+ SK+W T E + A R + L Y+DLYL+HWP
Sbjct: 60 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 119
Query: 125 GDT-------------WKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--RSQEAMRK 169
GD +ET ALE LV +GL++ +G+SNF+ + S ++R
Sbjct: 120 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 179
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCL 219
+ V Y + L+ + + G+ + AY+PL ++ +L +
Sbjct: 180 AVLQVECHPYLAQNE------LIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVV 233
Query: 220 AEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ ++YG++ AQ+ L + + + V+ IPK+ I +N + S E+ ++
Sbjct: 234 LALAEKYGRSPAQILLRWQV-QRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQ 287
>emb|CAB09639.1| (Z96801) putative oxidoreductase [Mycobacterium leprae]
Length = 306
Score = 93.6 bits (229), Expect = 2e-18
Identities = 87/272 (31%), Positives = 133/272 (47%), Gaps = 21/272 (7%)
Query: 15 GDDKVTAIGMGTWGIGGKEFPDYSKDR-ESIEALRYGLELGINLIDTAEFYGAGHSEELV 73
GD KV +G G + GK DR E++ LR +ELG+N IDTA+ YG SEE++
Sbjct: 35 GDLKVNRLGFGAMRLTGKGVWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEII 94
Query: 74 GKAIEGFNREEIFIVSK---------VWPTHFGYESAKKAARASAKRLGT-YIDLYLLHW 123
+A+ + + + I +K VW ++ S +RL IDL+ LH
Sbjct: 95 AEALHPY--KGLVIATKAGLLRTGRDVWIPLGNPSYLRQELEMSLRRLNVDTIDLFQLHR 152
Query: 124 PGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMD 183
+ + + + L L +EG IR+IG+S +L+ L +Q+ EIV Q Y+L
Sbjct: 153 IDPNF-PLADQVGELFTLKNEGKIRHIGLSEINLDQLTAAQQIT---EIVSVQNMYNLSA 208
Query: 184 RTPEETGLLDYMKREGITLMAYTPLEKGILAR-NKCLAEIGKRYGKTSAQVALNYLIWEE 242
R E LLD + GI + ++PL G LA + L I + T +Q+AL +L+
Sbjct: 209 RAAEP--LLDAVTSRGIGFIPWSPLAAGPLAAPDGPLQRIAVNHHATPSQLALAWLLKRS 266
Query: 243 NV-VAIPKASNKDHIKENFGAMGWRLSREDRE 273
V + IP S H++EN A LS ++ E
Sbjct: 267 PVMLPIPGTSRVAHLEENVAAAEISLSDDEFE 298
>gb|AAB97005.1| (AF039182) unknown [Fragaria x ananassa]
Length = 319
Score = 93.6 bits (229), Expect = 2e-18
Identities = 92/308 (29%), Positives = 147/308 (46%), Gaps = 56/308 (18%)
Query: 5 MAKVSD--FKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEA-LRYGLELGINLIDTA 61
MAKV GDD T M G+G +P D E+ +A + + G DTA
Sbjct: 1 MAKVPSVTLSSCGDDIQT---MPVIGMGTSSYP--RADPETAKAAILEAIRAGYRHFDTA 55
Query: 62 EFYGAGHSEELVGKAIEGF-------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT 114
YG SE+ +G+AI +R+E+FI +K+W + + + +AS L
Sbjct: 56 AAYG---SEKDLGEAIAEALRLQLIKSRDELFITTKLWASFAEKDLVLPSIKASLSNLQV 112
Query: 115 -YIDLYLLHWPGDTWKK---------------IEETLHALEELVDEGLIRYIGVSNFDLE 158
YID+Y++HWP K+ I+ A+EE GL R IGVSNF
Sbjct: 113 EYIDMYIIHWPFKLGKEVRTMPVERDLVQPLDIKSVWEAMEECKKLGLARGIGVSNFTSS 172
Query: 159 LLRRSQEAMRKYEI--VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARN 216
+L +E + EI VNQ++ M+ + L D+ K +GI + AY+PL AR
Sbjct: 173 ML---EELLSFAEIPPAVNQLE---MNPAWQLKKLRDFCKAKGIHVTAYSPLG---AART 223
Query: 217 K----------CLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWR 266
K + EI + GK++AQ++L + ++E+ V + K+ NK+ +++N +
Sbjct: 224 KWGDDRVLGSDIIEEIAQAKGKSTAQISLRW-VYEQGVSIVTKSYNKERMRQNLDIFDFC 282
Query: 267 LSREDRER 274
L+ E+ E+
Sbjct: 283 LTEEELEK 290
>emb|CAB55656.1| (AL117385) putative oxidoreductase [Streptomyces coelicolor A3(2)]
Length = 294
Score = 93.6 bits (229), Expect = 2e-18
Identities = 86/270 (31%), Positives = 120/270 (43%), Gaps = 21/270 (7%)
Query: 14 IGDDKVTAIGMGTWGIGGKEFPDYSKDRE-SIEALRYGLELGINLIDTAEFYGAGHSEEL 72
+GD VT G G + G DRE +I LR LGI IDTA YG + L
Sbjct: 19 LGDLTVTRFGYGAMQLAGPGVMGPPADREGAIAVLREAAALGITHIDTAGAYGPRVTNRL 78
Query: 73 VGKAIEGFNREEIFIVSKV---------WPTHFGYESAKKAARASAKRLGT----YIDLY 119
+ +A+ IV+KV WP E + A R + + LG ++L
Sbjct: 79 IREALRP-GPASAHIVTKVGAVRDQQGGWPPARRPEDLRHAVRENLEDLGLDALDVVNLR 137
Query: 120 LLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKY 179
L G + E L EL D+GLIR++GVSN E + EA IV Q Y
Sbjct: 138 LGDARGPRPGSLAEPFETLVELQDQGLIRHLGVSNATAE---QVAEAQAIAPIVCVQNMY 194
Query: 180 SLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYLI 239
+L R +E L+D + EGI + + PL ++ L + R G T VAL +L+
Sbjct: 195 NLAHRQDDE--LIDELAAEGIAYVPFFPLGGFTPLQSTALTAVATRLGATPMSVALAWLL 252
Query: 240 WEE-NVVAIPKASNKDHIKENFGAMGWRLS 268
N++ IP S+ H++EN G LS
Sbjct: 253 RRSPNILLIPGTSSVAHLRENVAGAGLSLS 282
>sp|P51635|ALDX_RAT ALCOHOL DEHYDROGENASE [NADP+] (ALDEHYDE REDUCTASE) (3-DG-REDUCING
ENZYME) >gi|484393|pir||JN0629 alcohol dehydrogenase (EC
1.1.1.1) - rat >gi|399660|dbj|BAA01627.1| (D10854)
aldehyde reductase [Rattus norvegicus]
Length = 325
Score = 92.4 bits (226), Expect = 5e-18
Identities = 79/295 (26%), Positives = 134/295 (44%), Gaps = 57/295 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+GTW K P K A++Y L +G ID A YG +E +G+A+
Sbjct: 13 KMPLIGLGTW----KSEPGQVK-----AAIKYALSVGYRHIDCASVYG---NETEIGEAL 60
Query: 78 E-------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE+F+ SK+W T E + A R + L Y+DLYL+HWP
Sbjct: 61 KESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFER 120
Query: 125 GDT-------------WKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--RSQEAMRK 169
GD +ET ALE LV +GL++ +G+SNF + S ++R
Sbjct: 121 GDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRP 180
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCL 219
+ V Y + L+ + + G+ + AY+PL ++ +L +
Sbjct: 181 AVLQVECHPYLAQNE------LIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVV 234
Query: 220 AEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ +++G++ AQ+ L + + + V+ IPK+ I +N + S E+ ++
Sbjct: 235 LALAEKHGRSPAQILLRWQV-QRKVICIPKSITPSRILQNIQVFDFTFSPEEMKQ 288
>sp|P28475|S6PD_MALDO NADP-DEPENDENT D-SORBITOL-6-PHOSPHATE DEHYDROGENASE
(ALDOSE-6-PHOSPHATE REDUCTASE [NADPH])
>gi|7488614|pir||T17013 D-sorbitol-6-phosphate
dehydrogenase, NADP-dependent - apple tree
>gi|217951|dbj|BAA01853.1| (D11080) NADP-dependent
D-sorbitol-6-phosphate dehydrogenase [Malus domestica]
>gi|3688805|gb|AAC97607.1| (AF057134) NADP-dependent
sorbitol 6-phosphate dehydrogenase [Malus x domestica]
>gi|445618|prf||1909365A NADP sorbitol phosphate
dehydrogenase [Malus domestica]
Length = 310
Score = 90.9 bits (222), Expect = 2e-17
Identities = 87/299 (29%), Positives = 140/299 (46%), Gaps = 66/299 (22%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
++ IG+G W + KD E E + +++G D A Y SE VG+A+
Sbjct: 11 EMPVIGLGLWRL--------EKD-ELKEVILNAIKIGYRHFDCAAHY---KSEADVGEAL 58
Query: 78 -EGFN-----REEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPG----- 125
E F REE+FI +K+W + G+ +A + S ++L Y+DLYL+H+P
Sbjct: 59 AEAFKTGLVKREELFITTKIWNSDHGH--VVEACKNSLEKLQIDYLDLYLVHYPMPTKHN 116
Query: 126 -----------------DTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMR 168
D +++T +E+ V GL+R IG+SN++L L R A
Sbjct: 117 AIGKTASLLGEDKVLDIDVTISLQQTWEGMEKTVSLGLVRSIGLSNYEL-FLTRDCLAYS 175
Query: 169 KYEIVVNQVKYSLMDRTP--EETGLLDYMKREGITLMAYTPLEKGILARNK--------- 217
K + V+Q + P + L+ + + G+ A+TPL G A NK
Sbjct: 176 KIKPAVSQ-----FETHPYFQRDSLVKFCMKHGVLPTAHTPL--GGAAANKDMFGSVSPL 228
Query: 218 ---CLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
L ++ K+YGK+ AQ+ L + I + V IPK+S +KEN + ++LS ED +
Sbjct: 229 DDPVLNDVAKKYGKSVAQICLRWGIQRKTAV-IPKSSKIQRLKENLEVLEFQLSDEDMQ 286
>gi|10946870 aldehyde reductase [Mus musculus]
>gi|7677318|gb|AAF67111.1|AF225564_1 (AF225564) aldehyde
reductase [Mus musculus]
Length = 325
Score = 90.9 bits (222), Expect = 2e-17
Identities = 79/295 (26%), Positives = 134/295 (44%), Gaps = 57/295 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+GTW K P K A+++ L G ID A YG +E +G+A+
Sbjct: 13 KMPLIGLGTW----KSEPGQVK-----AAIKHALSAGYRHIDCASVYG---NETEIGEAL 60
Query: 78 E-------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE+F+ SK+W T E + A R + L Y+DLYL+HWP
Sbjct: 61 KESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120
Query: 125 GDT-------------WKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--RSQEAMRK 169
GD +ET ALE LV +GL++ +G+SNF+ + S ++R
Sbjct: 121 GDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRP 180
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCL 219
+ V Y + L+ + G+ + AY+PL ++ +L +
Sbjct: 181 AVLQVECHPYLAQNE------LIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVV 234
Query: 220 AEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ +++G++ AQ+ L + + + V+ IPK+ N I +N + S E+ ++
Sbjct: 235 LALAEKHGRSPAQILLRWQV-QRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQ 288
>gi|5174695 aldo-keto reductase family 1, member D1; steroid-5-beta-reductase,
beta polypeptide 1 (3-oxo-5 beta-steroid delta
4-dehydrogenase beta 1); steroid 5-beta-reductase [Homo
sapiens] >gi|1703007|sp|P51857|3O5B_HUMAN
3-OXO-5-BETA-STEROID 4-DEHYDROGENASE
(DELTA(4)-3-KETOSTEROID 5-BETA-REDUCTASE)
>gi|542800|pir||S41120 cholestenone 5beta-reductase (EC
1.3.1.23) - human >gi|431857|emb|CAA82193.1| (Z28339)
delta 4-3-oxosteroid 5 beta-reductase [Homo sapiens]
>gi|11640835|gb|AAG39381.1| (AF283659) 5-beta steroid
reductase [Homo sapiens] >gi|740965|prf||2006243A
Delta4-3-oxosteroid 5beta reductase [Homo sapiens]
Length = 326
Score = 90.5 bits (221), Expect = 2e-17
Identities = 84/291 (28%), Positives = 132/291 (44%), Gaps = 47/291 (16%)
Query: 17 DKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHS--EELVG 74
+ + IG+GT+ P + +++ ++ G ID A Y H E +
Sbjct: 16 NSIPIIGLGTYSE-----PKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIRE 70
Query: 75 KAIEG-FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GDT 127
K EG RE+IF K+W T+ E + + + L Y+DLY++ P GD
Sbjct: 71 KIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDE 130
Query: 128 WKKIEE-------------TLHALEELVDEGLIRYIGVSNFD---LELLRRSQEAMRKYE 171
+E T A+E D GL++ +GVSNF+ LEL+ K++
Sbjct: 131 IYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGL--KHK 188
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARNKCLA 220
V NQV+ P+ LL + ++ I + AY+PL L ++ L
Sbjct: 189 PVSNQVECHPYFTQPK---LLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLN 245
Query: 221 EIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+GKRY KT+AQ+ L + I + VV IPK+ N + IKENF + L+ E+
Sbjct: 246 SLGKRYNKTAAQIVLRFNI-QRGVVVIPKSFNLERIKENFQIFDFSLTEEE 295
>dbj|BAA82867.1| (AB023951) delta4-3-oxosteroid 5beta-reductase [Oryctolagus
cuniculus]
Length = 326
Score = 90.5 bits (221), Expect = 2e-17
Identities = 87/295 (29%), Positives = 134/295 (44%), Gaps = 48/295 (16%)
Query: 14 IGD-DKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHS--E 70
+GD + + IG+GT+ P + +++ ++ G ID A Y H E
Sbjct: 12 LGDGNSIPIIGLGTYSE-----PKTTPKGSCATSVKIAIDTGYRHIDGAYIYQNEHEVGE 66
Query: 71 ELVGKAIEG-FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP---- 124
K EG RE+IF K+W T+ + + K L YIDLY++ P
Sbjct: 67 TFREKIAEGKVRREDIFYCGKLWATNHDPVMVRPTLERTLKVLKLDYIDLYIIEIPMAFK 126
Query: 125 -GDTWKKIEE-------------TLHALEELVDEGLIRYIGVSNFD---LELLRRSQEAM 167
GD +E T ALE D GL++ +GVSNF+ LELL
Sbjct: 127 PGDVVYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSLGVSNFNRQQLELLLNKPGL- 185
Query: 168 RKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----------EKGILARN 216
K++ V NQV+ P+ LL + ++ I ++AY+PL L ++
Sbjct: 186 -KHKPVCNQVECHPYFTQPK---LLKFCQQHDIIIVAYSPLGTCRNPMWVNTSLPPLLKD 241
Query: 217 KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
L +GK+Y KT+AQ+ L + + + VV IPK+ N + IKENF + L+ E+
Sbjct: 242 TLLNSLGKKYKKTAAQIVLRFNV-QRGVVVIPKSFNPERIKENFQIFDFSLTEEE 295
>gb|AAF13739.1|AF108435_1 (AF108435) NADPH-dependent codeinone reductase [Papaver somniferum]
Length = 321
Score = 90.5 bits (221), Expect = 2e-17
Identities = 84/285 (29%), Positives = 130/285 (45%), Gaps = 39/285 (13%)
Query: 20 TAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEG 79
+ I M G+G E +RE + L+ +E+G DTA Y SEE +G+AI
Sbjct: 13 SGIRMPALGMGTAETMVKGTEREKLAFLK-AIEVGYRHFDTAAAY---QSEECLGEAIAE 68
Query: 80 F-------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
+R+E+FI SK+W + A + S + L Y+DLYL+H P G
Sbjct: 69 ALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLEYLDLYLIHHPVSLKPGK 128
Query: 127 TWKKI----------EETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQ 176
+I + A+EE G R IGVSNF + L+ A K VVNQ
Sbjct: 129 FVNEIPKDHILPMDYKSVWAAMEECQTLGFTRAIGVSNFSCKKLQELMAAA-KIPPVVNQ 187
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYT-------PLEKGILARNKCLAEIGKRYGKT 229
V+ M T + L +Y K I + A++ P + +K L +I GK+
Sbjct: 188 VE---MSPTLHQKNLREYCKANNIMITAHSVLGAIGAPWGSNAVMDSKVLHQIAVARGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV++ + ++++ + K+ N+ +KEN W L+ ED E+
Sbjct: 245 VAQVSMRW-VYQQGASLVVKSFNEGRMKENLKIFDWELTAEDMEK 288
>pir||H83427 probable oxidoreductase PA1739 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9947716|gb|AAG05128.1|AE004600_4
(AE004600) probable oxidoreductase [Pseudomonas
aeruginosa]
Length = 323
Score = 90.1 bits (220), Expect = 3e-17
Identities = 85/305 (27%), Positives = 139/305 (44%), Gaps = 49/305 (16%)
Query: 13 RIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEA-LRYGLELGINLIDTAEFYGAGHS 69
R+G+ KV+ + +G G + + D E +R LE GI+ D+A+ Y G S
Sbjct: 5 RLGNSGLKVSRLCLGCMTYGDPAWRPWVLDEERARPFIREALEAGIDFFDSADIYSTGES 64
Query: 70 EELVGKAIEGF-NREEIFIVSKVW------PTHFGYESAKKAAR--ASAKRLGT-YIDLY 119
E ++G+A+ F RE++ I +K + P G A AS +RLGT Y+DL+
Sbjct: 65 ERILGRALRDFAQREDLVIATKAFFPMSDRPNACGLSRKHLLASVDASLRRLGTDYLDLF 124
Query: 120 LLH-WPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKY---EIVVN 175
++H + DT IEET L+ LV G +RY+G S+ + R + + +
Sbjct: 125 VIHRFDPDT--PIEETCETLDSLVRVGKVRYLGASSMPAWRFMKMLAFQRHHGLAQFISM 182
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNK------------------ 217
Q +Y+L+ R EE L+ + EGI L ++PL +G+LA +
Sbjct: 183 QSQYNLIVREDEE-DLVPLCREEGIALTPWSPLARGLLAGARSAGTLRTRTDEQAPRWYG 241
Query: 218 ----------CLAEIGKRYGKTSAQVALNYLIWEENVVA-IPKASNKDHIKENFGAMGWR 266
L ++ G AQ+AL +L+ V A I S H+++ A+
Sbjct: 242 GREEVESTLGALEKLAAARGLPPAQLALAWLLGRNGVAAPIVGLSRPHHLEDALAALTLD 301
Query: 267 LSRED 271
L+ E+
Sbjct: 302 LAEEE 306
>sp|P50578|ALDX_PIG ALCOHOL DEHYDROGENASE [NADP+] (ALDEHYDE REDUCTASE)
>gi|2981935|pdb|1AE4| Aldehyde Reductase Complexed With
Cofactor And Inhibitor, Alpha Carbon Atoms Only
>gi|1185557|gb|AAB60266.1| (U46064) aldehyde reductase
[Sus scrofa]
Length = 325
Score = 90.1 bits (220), Expect = 3e-17
Identities = 80/302 (26%), Positives = 131/302 (42%), Gaps = 71/302 (23%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+GTW K P K A++Y L +G ID A YG +E +G+A+
Sbjct: 13 KMPLIGLGTW----KSEPGQVK-----AAIKYALTVGYRHIDCAAIYG---NELEIGEAL 60
Query: 78 -------EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE+F+ SK+W T E + A R + L Y+DLYL+HWP
Sbjct: 61 TETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120
Query: 125 --------------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--R 162
DTWK ALE LV +GL+R +G+SNF +
Sbjct: 121 GDNPFPKNADGTIRYDATHYKDTWK-------ALEALVAKGLVRALGLSNFSSRQIDDVL 173
Query: 163 SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGI 212
S ++R + V Y + L+ + + G+ + AY+PL + +
Sbjct: 174 SVASVRPAVLQVECHPYLAQNE------LIAHCQARGLEVTAYSPLGSSDRAWRDPNEPV 227
Query: 213 LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDR 272
L + + ++Y ++ AQ+ L + + + V+ IPK+ I +N + S E+
Sbjct: 228 LLEEPVVQALAEKYNRSPAQILLRWQV-QRKVICIPKSVTPSRIPQNIQVFDFTFSPEEM 286
Query: 273 ER 274
++
Sbjct: 287 KQ 288
>pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holoenzyme
Length = 324
Score = 90.1 bits (220), Expect = 3e-17
Identities = 80/302 (26%), Positives = 131/302 (42%), Gaps = 71/302 (23%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+GTW K P K A++Y L +G ID A YG +E +G+A+
Sbjct: 12 KMPLIGLGTW----KSEPGQVK-----AAIKYALTVGYRHIDCAAIYG---NELEIGEAL 59
Query: 78 -------EGFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE+F+ SK+W T E + A R + L Y+DLYL+HWP
Sbjct: 60 TETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 119
Query: 125 --------------------GDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--R 162
DTWK ALE LV +GL+R +G+SNF +
Sbjct: 120 GDNPFPKNADGTIRYDATHYKDTWK-------ALEALVAKGLVRALGLSNFSSRQIDDVL 172
Query: 163 SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGI 212
S ++R + V Y + L+ + + G+ + AY+PL + +
Sbjct: 173 SVASVRPAVLQVECHPYLAQNE------LIAHCQARGLEVTAYSPLGSSDRAWRDPNEPV 226
Query: 213 LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDR 272
L + + ++Y ++ AQ+ L + + + V+ IPK+ I +N + S E+
Sbjct: 227 LLEEPVVQALAEKYNRSPAQILLRWQV-QRKVICIPKSVTPSRIPQNIQVFDFTFSPEEM 285
Query: 273 ER 274
++
Sbjct: 286 KQ 287
>pir||T48188 aldose reductase-like protein - Arabidopsis thaliana
>gi|7327826|emb|CAB82283.1| (AL161946) aldose
reductase-like protein [Arabidopsis thaliana]
Length = 320
Score = 88.9 bits (217), Expect = 6e-17
Identities = 78/288 (27%), Positives = 130/288 (45%), Gaps = 43/288 (14%)
Query: 8 VSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAG 67
+ F+ + K+ A+G+GTW G + + A+ +E G IDTA YG
Sbjct: 13 MESFRLLSGHKIPAVGLGTWRSGSQAA------HAVVTAI---VEGGYRHIDTAWEYG-- 61
Query: 68 HSEELVGKAIE-----GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLL 121
+ VG+ I+ G R ++F+ SK+W T E + A + + K L Y+DLYL+
Sbjct: 62 -DQREVGQGIKRAMHAGLERRDLFVTSKLWCTELSPERVRPALQNTLKELQLEYLDLYLI 120
Query: 122 HWP-------------GDTWK-KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAM 167
HWP GD +E +E L + L+R IGV NF + L + +
Sbjct: 121 HWPIRLREGASKPPKAGDVLDFDMEGVWREMENLSKDSLVRNIGVCNFTVTKLNK----L 176
Query: 168 RKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL--EKG--ILARNKCLAEIG 223
+ ++ V M +L++ K+ I AY+PL ++G L ++ + I
Sbjct: 177 LGFAELIPAVCQMEMHPGWRNDRILEFCKKNEI--HAYSPLGSQEGGRDLIHDQTVDRIA 234
Query: 224 KRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
K+ KT Q+ + + + + IPK+ N + IKEN W + +D
Sbjct: 235 KKLNKTPGQILVKWGL-QRGTSVIPKSLNPERIKENIKVFDWVIPEQD 281
>prf||1403439A aldehyde reductase [Homo sapiens]
Length = 323
Score = 88.5 bits (216), Expect = 8e-17
Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 58/295 (19%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ IG+GTW K P K A++Y L +G ID A YG +E +G+A+
Sbjct: 12 KMPLIGLGTW----KSEPGQVK-----AAVKYALSVGYRHIDCAAIYG---NEPEIGEAL 59
Query: 78 E-------GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
+ REE+F+ SK+W T E + A R + L Y+DLYL+HWP
Sbjct: 60 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 119
Query: 125 GDT-------------WKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--RSQEAMRK 169
GD +ET ALE LV +GL++ +G+SNF+ + S ++R
Sbjct: 120 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 179
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL----------EKGILARNKCL 219
+ V Y + L+ + + G+ + AY PL ++ +L +
Sbjct: 180 AVLQVECHPYLAQNE------LIAHCQARGLEVTAY-PLGSSDRAWRDPDEPVLLEEPVV 232
Query: 220 AEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ ++YG++ AQ+ L + + + V+ IPK+ I +N + S E+ ++
Sbjct: 233 LALAEKYGRSPAQILLRWQV-QRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQ 286
>gb|AAD42404.1|AF157493_12 (AF157493) 2,5-diketo-D-gluconate reductase [Zymomonas mobilis]
Length = 282
Score = 88.2 bits (215), Expect = 1e-16
Identities = 83/263 (31%), Positives = 126/263 (47%), Gaps = 22/263 (8%)
Query: 15 GDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVG 74
G+D + A+G GT+ + G + + +++G L+D+A Y +E VG
Sbjct: 15 GND-LPAVGFGTYKLNGSA---------GVSDIVSAIKVGYRLLDSAFNY---ENEGAVG 61
Query: 75 KAIE--GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWKKI 131
+ G R+++ IVSK+ H +E A S R Y DLYL+HWP +
Sbjct: 62 EVFREAGIARDKLRIVSKLPGRHHHFEEAIATVEESLYRAQLDYYDLYLIHWPNPSKDLY 121
Query: 132 EETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGL 191
E AL E +GLIR IGV NF E L R + VVNQV+ L P+E
Sbjct: 122 VEAWQALIEARKKGLIRSIGVCNFLPEHLERLIKE-TGVTPVVNQVE--LHPYFPQEEQR 178
Query: 192 LDYMKREGITLMAYTPLEKGI-LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKA 250
+ K GI +++PL + L ++ + +I R GK+ QV L + + + + IPKA
Sbjct: 179 A-WDKAHGIVTESWSPLGRASKLLQDDTIKKIADRLGKSIPQVILRWHV-QLGAIPIPKA 236
Query: 251 SNKDHIKENFGAMGWRLSREDRE 273
S+K+ EN + LS +D E
Sbjct: 237 SSKERQIENLSLFDFELSPQDVE 259
>sp|P31210|3O5B_RAT 3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (DELTA(4)-3-KETOSTEROID
5-BETA-REDUCTASE) >gi|109509|pir||S20272
3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6) -
mouse >gi|111296|pir||S15835 3-oxo-5beta-steroid
4-dehydrogenase (EC 1.3.99.6) - rat
>gi|456303|dbj|BAA04131.1| (D17309)
delta-4-3-ketosteroid 5-beta-reductase [Rattus
norvegicus] >gi|9438775|gb|AAB35916.2| (S80431) delta
4-3-ketosteroid 5 beta-reductase [Rattus sp.]
Length = 326
Score = 87.4 bits (213), Expect = 2e-16
Identities = 87/298 (29%), Positives = 135/298 (45%), Gaps = 61/298 (20%)
Query: 17 DKVTAIGMGTWG----IGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHS--E 70
+ + IG+GT+ + GK F A++ ++ G ID A Y H E
Sbjct: 16 NSIPIIGLGTYSDPRPVPGKTFI----------AVKTAIDEGYRHIDGAYVYRNEHEVGE 65
Query: 71 ELVGKAIEG-FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP---- 124
+ K EG REEIF K+W T E + A + + L YIDLY++ P
Sbjct: 66 AIREKVAEGKVKREEIFYCGKLWSTDHDPEMVRPALERTLQTLKLDYIDLYIIEMPMAFK 125
Query: 125 -GDTWKKIEE-------------TLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMR-- 168
G+ + +E T ALE D GL++ +GVSNF+ RR E +
Sbjct: 126 PGEEFYPKDENGRVIYHKSNLCATWEALEACKDAGLVKSLGVSNFN----RRQLEVILNK 181
Query: 169 ---KYEIVVNQVKYSLMDRTPEETGLLDYMKREGIT-LMAYTPL-----------EKGIL 213
KY+ V NQV+ +T LL+ + ++AY+PL L
Sbjct: 182 PGLKYKPVTNQVECHPYFT---QTKLLEVSASSMTSFIVAYSPLGTCRNPLWVNVSSPPL 238
Query: 214 ARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+++ L +GK+Y KT AQ+ L + I + +V IPK++ + IKENF + L++E+
Sbjct: 239 LKDELLTSLGKKYNKTQAQIVLRFDI-QRGLVVIPKSTTPERIKENFQIFDFSLTKEE 295
>gb|AAD31332.1|AC007354_5 (AC007354) Strong similarity to gb|X56267 auxin-induced protein
(pCNT115) from Nicotiana tabacum and is a member of the
PF|00248 Aldo/keto reductase family. [Arabidopsis
thaliana]
Length = 348
Score = 87.0 bits (212), Expect = 2e-16
Identities = 93/317 (29%), Positives = 151/317 (47%), Gaps = 57/317 (17%)
Query: 5 MAKVSDFKRI--GDD--KVTAIGMGTWGIGGKEFPDYSK-DRESIEALRYGLELGINLID 59
MA S +RI G +V+A G+G G+ F +K + + I + + + GI L+D
Sbjct: 1 MAAASGVRRIKLGSQGLEVSAQGLGCMGLS--IFDGTTKVETDLIALIHHAINSGITLLD 58
Query: 60 TAEFYGAGHSEELVGKAIEGFNREEIFIVSK----VWPTHFGYES----AKKAARASAKR 111
T++ YG +E L+G+A++ RE++ + +K + GY + A AS +R
Sbjct: 59 TSDIYGPETNELLLGQALKDGMREKVELATKFGLLLKDQKLGYRGDPAYVRAACEASLRR 118
Query: 112 LG-TYIDLYLLHWPGDTWKKIEETL-------------HALEELVDEGLIRYIGVSNFDL 157
LG + IDLY H DT IE TL L++LV+EG I+YIG+S
Sbjct: 119 LGVSCIDLYYQH-RIDTTVPIEVTLIVMVLSCPAISKIGELKKLVEEGKIKYIGLSEACA 177
Query: 158 ELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA--- 214
+RR+ + + Q+++SL R EE ++ + GI ++AY+PL G A
Sbjct: 178 STIRRAHAV---HPLTAVQLEWSLWSRDVEE-DIIPTCRELGIGIVAYSPLGLGFFAAGP 233
Query: 215 ---------------RNKCLAE----IGKRYGKTSAQVALNYLIWEEN-VVAIPKASNKD 254
NK L E + ++ T AQ+AL ++ + N V IP S
Sbjct: 234 KFIESMDNGDYRKANHNKILYEKVNAMAEKKSCTPAQLALAWVHHQGNDVCPIPGTSKIK 293
Query: 255 HIKENFGAMGWRLSRED 271
++ +N GA+ +LS E+
Sbjct: 294 NLNQNIGALSVKLSIEE 310
>emb|CAC16987.1| (AL450350) putative oxidoreductase [Streptomyces coelicolor]
Length = 285
Score = 87.0 bits (212), Expect = 2e-16
Identities = 80/283 (28%), Positives = 133/283 (46%), Gaps = 32/283 (11%)
Query: 12 KRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG-----A 66
+ IG V+AIG+G + + PD + SI + L+ G+ LIDTA+ Y
Sbjct: 4 RTIGGRSVSAIGLGGMPMSIEGRPDPER---SIATIHAALDAGVTLIDTADSYHRDANEV 60
Query: 67 GHSEELVGKAIEGFNRE--EIFIVSK---------VWPTHFGYESAKKAARASAKRLGT- 114
GH+EEL+ +A+ + ++ + +K W + K+AA+ SA+RLG
Sbjct: 61 GHNEELIARALREYGAAGADVLVATKGGHLRPGDGTWTRNGDPAYLKRAAKESARRLGVD 120
Query: 115 YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAM-RKYEIV 173
I LY H P D +++ AL EL+DEG+I G+SN + + ++E + + V
Sbjct: 121 AIGLYQFHRP-DPAVPYADSVGALRELLDEGVILMAGISNAGIAQIDEAREVLGGRLVSV 179
Query: 174 VNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-----EKGILARNKCLAEIGKRYGK 228
NQ + E L++ GI + ++PL K + AR+ ++ G
Sbjct: 180 QNQFSPAFRSSRSE----LEHCAGLGIAFLPWSPLGGIANAKELAARHGVFQQVADETGT 235
Query: 229 TSAQVALNY-LIWEENVVAIPKASNKDHIKENFGAMGWRLSRE 270
+ QVAL + L V+ IP AS I+++ A L+R+
Sbjct: 236 SVHQVALAWQLALAPVVIPIPGASRPASIRDSAAAADLELTRD 278
>dbj|BAA12182.1| (D83992) probable reductase, most similar to pir:A32950 probable
reductase protein (33.6% identity in 238 aa overlap
[Schizosaccharomyces pombe]
Length = 276
Score = 86.6 bits (211), Expect = 3e-16
Identities = 72/231 (31%), Positives = 115/231 (49%), Gaps = 17/231 (7%)
Query: 51 LELGINLIDTAEFYGAGHSEELVGKAIEGF-------NREEIFIVSKVWPTHFGYESAKK 103
L LGI +ID+A Y +E+ +AI+ F RE+I +++K+ + G+E K
Sbjct: 34 LSLGIRVIDSAITY---RNEKECEQAIQDFCHQNVNIKREDITLITKIPDSLQGFERTWK 90
Query: 104 AARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRR 162
A S +R G +D+ L+H P ++IE + AL + EG I IGVSN+++ L
Sbjct: 91 AVXQSLRRTGRPKLDVVLIHSPKWPVRRIE-SWRALLQHQKEGRINKIGVSNYNIHHLEE 149
Query: 163 SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEI 222
+NQV++S + P L Y GI + A++PL +G + L ++
Sbjct: 150 IISLGLPLP-AINQVEFSAFNNRPT---FLSYCFNHGILVQAFSPLTRGYRLSDIRLLDL 205
Query: 223 GKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
+Y KT A + L Y + ++ V I KAS+ HI EN A + L D +
Sbjct: 206 SLKYNKTPANILLRYCL-QKGVSPISKASSFVHIHENVKAEQFMLDPSDMD 255
>gb|AAF13738.1|AF108434_1 (AF108434) NADPH-dependent codeinone reductase [Papaver somniferum]
Length = 321
Score = 86.6 bits (211), Expect = 3e-16
Identities = 82/285 (28%), Positives = 129/285 (44%), Gaps = 39/285 (13%)
Query: 20 TAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEG 79
+ I M G+G E +RE + L+ +E+G DTA Y SEE +G+AI
Sbjct: 13 SGIRMPALGMGTAETMVKGTEREKLAFLK-AIEVGYRHFDTAAAY---QSEECLGEAIAE 68
Query: 80 F-------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
+R+E+FI SK+W + A + S + L Y+DLYL+H P G
Sbjct: 69 ALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLDYLDLYLIHHPVSLKPGK 128
Query: 127 TWKKI----------EETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQ 176
+I + A+EE G R IGV NF + L+ A K VVNQ
Sbjct: 129 FVNEIPKDHILPMDYKSVWAAMEECQTLGFTRAIGVCNFSCKKLQELMAAA-KIPPVVNQ 187
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYT-------PLEKGILARNKCLAEIGKRYGKT 229
V+ M T + L +Y K I + A++ P + +K L +I GK+
Sbjct: 188 VE---MSPTLHQKNLREYCKANNIMITAHSVLGAICAPWGSNAVMDSKVLHQIAVARGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV++ + ++++ + K+ N+ +KEN W L+ E+ E+
Sbjct: 245 VAQVSMRW-VYQQGASLVVKSFNEGRMKENLKIFDWELTAENMEK 288
>pir||T40048 probable oxidoreductase - fission yeast (Schizosaccharomyces pombe)
>gi|6018689|emb|CAB57934.1| (AL121795) putative
oxidoreductase [Schizosaccharomyces pombe]
Length = 276
Score = 85.8 bits (209), Expect = 5e-16
Identities = 72/231 (31%), Positives = 115/231 (49%), Gaps = 17/231 (7%)
Query: 51 LELGINLIDTAEFYGAGHSEELVGKAIEGF-------NREEIFIVSKVWPTHFGYESAKK 103
L LGI +ID+A Y +E+ +AI+ F RE+I +++K+ + G+E K
Sbjct: 34 LSLGIRVIDSAITY---RNEKECEQAIQDFCHQNVNIKREDITLITKIPDSLQGFERTWK 90
Query: 104 AARASAKRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRR 162
A S +R G +D+ L+H P ++IE + AL + EG I IGVSN+++ L
Sbjct: 91 AVEQSLRRTGRPKLDVVLIHSPKWPVRRIE-SWRALLQHQKEGRINKIGVSNYNIHHLEE 149
Query: 163 SQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEI 222
+NQV++S + P L Y GI + A++PL +G + L ++
Sbjct: 150 IISLGLPLP-AINQVEFSAFNNRPT---FLSYCFNHGILVQAFSPLTRGYRLSDIRLLDL 205
Query: 223 GKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRE 273
+Y KT A + L Y + ++ V I KAS+ HI EN A + L D +
Sbjct: 206 SLKYNKTPANILLRYCL-QKGVSPIFKASSFVHIHENVKAEQFMLDPSDMD 255
>gb|AAF13737.1|AF108433_1 (AF108433) NADPH-dependent codeinone reductase [Papaver somniferum]
Length = 321
Score = 85.8 bits (209), Expect = 5e-16
Identities = 83/285 (29%), Positives = 129/285 (45%), Gaps = 39/285 (13%)
Query: 20 TAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEG 79
+ I M G+G E + +RE + L +E+G DTA Y SEE +G+AI
Sbjct: 13 SGIRMPALGMGTVETMEKGTEREKLAFLN-AIEVGYRHFDTAAAY---QSEECLGEAIAE 68
Query: 80 F-------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
+R+E+FI SK+W + A + S + L Y+DLYL+H P G
Sbjct: 69 ALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLEYLDLYLIHHPVSLKPGK 128
Query: 127 TWKKI----------EETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQ 176
+I + A+EE G R IGVSNF + L+ A K VVNQ
Sbjct: 129 LVNEIPKDHILPMDYKSVWAAMEECQTLGFTRAIGVSNFSCKKLQELM-ATAKIPPVVNQ 187
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYT-------PLEKGILARNKCLAEIGKRYGKT 229
V+ M T + L +Y K I + A++ P + +K L +I GK+
Sbjct: 188 VE---MSPTLHQKNLREYCKANNIMITAHSVLGAIGAPWGSNAVMDSKVLHQIAVARGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV++ + ++++ + K+ N+ +KEN L+ ED E+
Sbjct: 245 VAQVSMRW-VYQQGASLVVKSFNEARMKENLKIFDSELTAEDMEK 288
>gb|AAF13736.1|AF108432_1 (AF108432) NADPH-dependent codeinone reductase [Papaver somniferum]
Length = 321
Score = 85.4 bits (208), Expect = 7e-16
Identities = 81/285 (28%), Positives = 128/285 (44%), Gaps = 39/285 (13%)
Query: 20 TAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIEG 79
+ I M G+G E +RE + L+ +E+G DTA Y +EE +G+AI
Sbjct: 13 SGIRMPALGMGTAETMVKGTEREKLAFLK-AIEVGYRHFDTAAAY---QTEECLGEAIAE 68
Query: 80 F-------NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GD 126
+R+E+FI SK+W + A + S + L Y+DLYL+H P G
Sbjct: 69 ALQLGLIKSRDELFITSKLWCADAHADLVLPALQNSLRNLKLDYLDLYLIHHPVSLKPGK 128
Query: 127 TWKKI----------EETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQ 176
+I + A+EE G R IGV NF + L+ E VVNQ
Sbjct: 129 FVNEIPKDHILPMDYKSVWAAMEECQTLGFTRAIGVCNFSCKRLQELMETANSPP-VVNQ 187
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYTPLEK-------GILARNKCLAEIGKRYGKT 229
V+ M T + L +Y K I + A++ L + +K L +I GK+
Sbjct: 188 VE---MSPTLHQKNLREYCKANNIMITAHSVLGAVGAAWGTNAVMHSKVLHQIAVARGKS 244
Query: 230 SAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
AQV++ + ++++ + K+ N+ +KEN W L+ ED E+
Sbjct: 245 VAQVSMRW-VYQQGASLVVKSFNEARMKENLKIFDWELTAEDMEK 288
>gb|AAB80621.1| (AC002376) Match to Arabidopsis ATHKCP (gb|L40948). ESTs
gb|ATTS0764, gb|R90646, gb|AA389809, gb|ATTS2615 come
from this gene. [Arabidopsis thaliana]
>gi|3126868|gb|AAC15999.1| (AF061570) potassium channel
beta subunit homolog [Arabidopsis thaliana]
Length = 328
Score = 85.0 bits (207), Expect = 9e-16
Identities = 64/218 (29%), Positives = 107/218 (48%), Gaps = 20/218 (9%)
Query: 11 FKRIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGH 68
+K +G KV+ + G W G + D + + ++ R + G+N D AE Y G
Sbjct: 3 YKNLGKSGLKVSTLSFGAWVTFGNQL-DVKEAKSILQCCR---DHGVNFFDNAEVYANGR 58
Query: 69 SEELVGKAIE--GFNREEIFIVSKVW-----PTHFGY--ESAKKAARASAKRLG-TYIDL 118
+EE++G+AI G+ R +I I +K++ P G + + +AS KRL Y+D+
Sbjct: 59 AEEIMGQAIRELGWRRSDIVISTKIFWGGPGPNDKGLSRKHIVEGTKASLKRLDMDYVDV 118
Query: 119 YLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV---VN 175
H P D IEET+ A+ ++D+G Y G S + + + + A + ++V V
Sbjct: 119 LYCHRP-DASTPIEETVRAMNYVIDKGWAFYWGTSEWSAQQITEAWGAADRLDLVGPIVE 177
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGIL 213
Q +Y++ R ET L GI L ++PL G+L
Sbjct: 178 QPEYNMFARHKVETEFLPLYTNHGIGLTTWSPLASGVL 215
>gb|AAD09330.1| (AF020040) xylose reductase [Pichia guilliermondii]
Length = 317
Score = 85.0 bits (207), Expect = 9e-16
Identities = 84/305 (27%), Positives = 143/305 (46%), Gaps = 67/305 (21%)
Query: 21 AIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI--- 77
++G G W + D + +++G L D AE YG +E+ VG I
Sbjct: 13 SVGFGCWKVDNATCAD---------TIYNAIKVGYRLFDGAEDYG---NEKEVGDGINRA 60
Query: 78 --EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP--------- 124
EG R+E+F+VSK+W + ++ +KA + L Y+DL+L+H+P
Sbjct: 61 LDEGLVARDELFVVSKLWNSFHDPKNVEKALDKTLSDLKVDYLDLFLIHFPIAFKFVPFE 120
Query: 125 -----------GDTWK----KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRK 169
GD + + +T ALE+LV++G IR IG+SNF L+ Q+ +R
Sbjct: 121 EKYPPGFYCGDGDKFHYEDVPLIDTWRALEKLVEKGKIRSIGISNFSGALI---QDLLRS 177
Query: 170 YEI--VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYT------------PLEKGI--L 213
+I V Q+++ + P L++Y++ +GI + AY+ P K + L
Sbjct: 178 AKIKPAVLQIEHHPYLQQPR---LVEYVQSQGIAITAYSSFGPQSFVELDHPRVKDVKPL 234
Query: 214 ARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED-R 272
+ + + + KT AQV L + + + IPK++N D + N + LS+ED +
Sbjct: 235 FEHDVIKSVAGKVKKTPAQVLLRWAT-QRGLAVIPKSNNPDRLLSNLKVNDFDLSQEDFQ 293
Query: 273 ERAKL 277
E +KL
Sbjct: 294 EISKL 298
>dbj|BAA19477.1| (AB002106) D-xylose reductase II,III [Candida tropicalis]
Length = 324
Score = 84.7 bits (206), Expect = 1e-15
Identities = 79/304 (25%), Positives = 140/304 (45%), Gaps = 67/304 (22%)
Query: 22 IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI---- 77
+G G W + + D + ++ G L D AE YG +E+ VG+ I
Sbjct: 21 VGFGCWKVNNETAADQ---------IYNAIKTGYRLFDGAEDYG---NEKEVGEGINRAI 68
Query: 78 -EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWP---------- 124
EG REE+FI SK+W ++ + A + L Y+DL+L+H+P
Sbjct: 69 KEGLVKREELFITSKLWNNFHDPKNVETALNKTLSDLNLDYVDLFLIHFPIAFKFVPIEE 128
Query: 125 ----------GDTWK----KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKY 170
GD + + +T ALE+LV+ G I+ IG+SNF L+ + +R
Sbjct: 129 KYPPGFYCGDGDNFHYEDVPLLDTWKALEKLVEAGKIKSIGISNFTGALI---YDLIRGA 185
Query: 171 EI--VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYT--------------PLEKGILA 214
I V Q+++ + P+ L++Y+++ GI + Y+ L L
Sbjct: 186 TIKPAVLQIEHHPYLQQPK---LIEYVQKAGIAITGYSSFGPQSFLELESKRALNTPTLF 242
Query: 215 RNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
++ + I ++GK+ AQV L + + N+ IPK++N + + +N + + L+++D +
Sbjct: 243 EHETIKSIADKHGKSPAQVLLRWAT-QRNIAVIPKSNNPERLAQNLSVVDFDLTKDDLDN 301
Query: 275 -AKL 277
AKL
Sbjct: 302 IAKL 305
>gb|AAA87294.1| (L40948) K+ channel protein [Arabidopsis thaliana]
Length = 328
Score = 84.3 bits (205), Expect = 2e-15
Identities = 63/218 (28%), Positives = 107/218 (48%), Gaps = 20/218 (9%)
Query: 11 FKRIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGH 68
+K +G KV+ + G W G + D + + ++ R + G+N D AE Y G
Sbjct: 3 YKNLGKSGLKVSTLSFGAWVTFGNQL-DVKEAKSILQCCR---DHGVNFFDNAEVYANGR 58
Query: 69 SEELVGKAIE--GFNREEIFIVSKVW-----PTHFGY--ESAKKAARASAKRLG-TYIDL 118
+EE++G+AI G+ R +I I +K++ P G + + +AS KRL Y+D+
Sbjct: 59 AEEIMGQAIRELGWRRSDIVISTKIFWGGPGPNDKGLSRKHIVEGTKASLKRLDMDYVDV 118
Query: 119 YLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV---VN 175
H P D IEE + A+ ++D+G Y G+S + + + + A + ++V V
Sbjct: 119 LYCHRP-DASTPIEEAVRAMNYVIDKGWAFYWGISEWSAQQITEAWGAADRLDLVGPIVE 177
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGIL 213
Q +Y++ R ET L GI L ++PL G+L
Sbjct: 178 QPEYNMFARHKVETEFLPLYTNHGIGLTTWSPLASGVL 215
>pir||A75289 probable potassium channel, beta subunit - Deinococcus radiodurans
(strain R1) >gi|6460125|gb|AAF11861.1|AE002063_4
(AE002063) potassium channel, beta subunit, putative
[Deinococcus radiodurans]
Length = 315
Score = 83.9 bits (204), Expect = 2e-15
Identities = 80/310 (25%), Positives = 139/310 (44%), Gaps = 49/310 (15%)
Query: 10 DFKRIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAG 67
+++++G KV+ + +G W G D SK I +R + G+N D A+ Y G
Sbjct: 2 EYRKLGKSGLKVSEVALGGWETYGVN-QDASKMVGDI--VRAAYDEGVNFFDQADVYARG 58
Query: 68 HSEELVGKAIEGFNREEIFIVSKV-WPTH-------FGYESAKKAARASAKRLGT-YIDL 118
SE+L+G + F R + + SKV WP + ++ S +RLGT Y+D+
Sbjct: 59 QSEQLMGAVLRDFPRHTLVLSSKVFWPMSDDVNDRGLSRKHVLESIDGSLRRLGTDYLDI 118
Query: 119 YLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQE---AMRKYEIVVN 175
Y H D +EE + A ++++ +G Y G S + + ++ E A + V
Sbjct: 119 YFAH-RYDPEVPMEEIVMAFDQVIRDGKALYWGTSMWPAARIAQAVEFAKANGLHAPVTE 177
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA--------------------- 214
Q +YS++ R E +L Y + GI L+ ++PL G+L
Sbjct: 178 QPEYSMVRRDRVEQEILPYTEGAGIGLVVWSPLAMGLLTGKYDEGRPEGARLTEKENWAG 237
Query: 215 ---------RNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNK-DHIKENFGAMG 264
+ + L I G T AQ+AL +L+ ++ V ++ + K + I++ A G
Sbjct: 238 SYLTDENIQKVRDLKSIADDLGVTRAQLALAWLLRQKGVSSVITGATKVNQIQDTVKAAG 297
Query: 265 WRLSREDRER 274
RLS + + R
Sbjct: 298 VRLSDDVQRR 307
>sp|P78736|XYL1_PACTA NAD(P)H-DEPENDENT XYLOSE REDUCTASE (XR) >gi|1674392|gb|AAC49526.1|
(U40706) aldose reductase [Pachysolen tannophilus]
Length = 318
Score = 83.9 bits (204), Expect = 2e-15
Identities = 89/306 (29%), Positives = 132/306 (43%), Gaps = 65/306 (21%)
Query: 18 KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAI 77
K+ AIGMG W + Y+ +E G L D A YG +E+ VG+ I
Sbjct: 13 KIPAIGMGCWKLENAADMVYAAIKE-----------GYRLFDCACDYG---NEKEVGEGI 58
Query: 78 EG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP------ 124
R+++FI SK+W E+ KKA S Y DLYL+H+P
Sbjct: 59 NRAIKDGLVKRKDLFITSKLWNNFHAKENVKKALMKSLSDFNLDYFDLYLMHFPISFKFV 118
Query: 125 ------------GDTWK------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEA 166
GD K I ET A+E LVDEGL++ IGVSN LL +A
Sbjct: 119 PFEEKYPPGFYCGDGDKFIYEDVPIIETWRAMENLVDEGLVKSIGVSNVSGGLLEDLIKA 178
Query: 167 MRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTP------LEKG--------I 212
R + + + ++ L++Y + +GI + Y+ LE G
Sbjct: 179 ARIKPASLQIEHHPYL----QQNKLVEYAQLKGIVVTGYSNFGPLSFLELGNETAKKTQP 234
Query: 213 LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED- 271
L NK + I ++GKT QV L + + + + IPK++ + + N + L++ED
Sbjct: 235 LYENKTITTIAAKHGKTPFQVLLRW-VNQRGIAIIPKSTFPNTLAVNLHVDEFDLTKEDF 293
Query: 272 RERAKL 277
E AKL
Sbjct: 294 EEIAKL 299
>pir||T07394 probable potassium channel beta chain KB1 - potato
>gi|3402279|emb|CAA04451.1| (AJ000999) putative
beta-subunit of K+ channels [Solanum tuberosum]
Length = 330
Score = 83.5 bits (203), Expect = 3e-15
Identities = 63/218 (28%), Positives = 106/218 (47%), Gaps = 20/218 (9%)
Query: 11 FKRIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGH 68
+K +G KV+ + G W G + D + + ++ R + G+N D AE Y G
Sbjct: 5 YKNLGRSGLKVSQLSYGAWVTFGNQL-DVKEAKTLLQCCR---DHGVNFFDNAEVYANGR 60
Query: 69 SEELVGKAIE--GFNREEIFIVSKVW-----PTHFGYESAK--KAARASAKRLG-TYIDL 118
+E ++G+AI G+ R +I + +K++ P G + +AS KRL Y+DL
Sbjct: 61 AERIMGQAIRELGWKRSDIVVSTKIFWGGSGPNDKGLSRKHIIEGTKASLKRLDMDYVDL 120
Query: 119 YLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV---VN 175
H P DT IEET+ A+ ++D+G Y G S + + + + ++ ++V V
Sbjct: 121 IYCHRP-DTSTPIEETVRAMNYVIDKGWAFYWGTSEWSAQQITEAWGVAQRLDLVGPIVE 179
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGIL 213
Q +Y L+ R E+ L GI L ++PL G+L
Sbjct: 180 QPEYKLLSRHKVESEYLPLYSNYGIGLTTWSPLASGVL 217
>pir||T22567 hypothetical protein F53F1.3 - Caenorhabditis elegans
>gi|3877460|emb|CAB03128.1| (Z81088) contains similarity
to Pfam domain: PF00248 (Aldo/keto reductase family),
Score=460.5, E-value=4.4e-135, N=1 [Caenorhabditis
elegans]
Length = 283
Score = 83.1 bits (202), Expect = 3e-15
Identities = 81/276 (29%), Positives = 131/276 (47%), Gaps = 42/276 (15%)
Query: 22 IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKAIE--- 78
IG+GT+ I G + + L L G L DTA+ Y ++E+ +G A+E
Sbjct: 14 IGLGTYKIIGDQV---------LPVLDAALTAGYRLFDTAKVY---NNEKEIGDALEILL 61
Query: 79 ---GFNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP-----GDTWK 129
RE+IFI +K+ P E+ KK S L T YID+YL+H+P GD
Sbjct: 62 PKHNLKREDIFITTKMHPNTV--ENVKKLVDESLSLLKTSYIDMYLIHYPKSFDYGDQ-D 118
Query: 130 KIEETLHA-----LEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDR 184
+ +TL L E + G IR +GVS+F++ L ++ + + NQV+Y
Sbjct: 119 PMNKTLRIATWNDLWECKNAGKIRSVGVSSFEIRHLEELKDLGKNFPPCCNQVEYH-PHF 177
Query: 185 TPEETGLLDYMKREGITLMAYTPLEK--GILARNKCLAEIGKRYGKTSAQVALNYLIWEE 242
T EE L +Y K EGI A++ L + L ++ + + ++Y V L++ +
Sbjct: 178 TREE--LKNYCKSEGIFFQAFSSLARHNETLLSSEIITRLAEKYHVPKTTVLLSWAT-SQ 234
Query: 243 NVVAIPKASNKDHIKENFGAMGWRLSREDRERAKLC 278
V IPK++N + + +N + E+ E K+C
Sbjct: 235 KVGIIPKSTNPERLAQNLKT----VLLEEEEVKKIC 266
>pir||A64669 probable aldo-keto reductase (EC 1.-.-.-) - Helicobacter pylori
(strain 26695) >gi|2314358|gb|AAD08243.1| (AE000625)
aldo-keto reductase, putative [Helicobacter pylori
26695]
Length = 329
Score = 82.7 bits (201), Expect = 4e-15
Identities = 86/308 (27%), Positives = 147/308 (46%), Gaps = 54/308 (17%)
Query: 12 KRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEE 71
+ +G KV A+ +G G+ + + ++ ++ + LELGIN DTAE YG +E+
Sbjct: 4 RHLGPLKVGALALGCMGMT-YGYGEVHDKKQMVKLIHKALELGINFFDTAEAYGE-DNEK 61
Query: 72 LVGKAIEGFNREEIFIVSKV----------WPTHFGYES---AKKAARASAKRLGT-YID 117
L+G+AI+ F ++++ + SK + T F S K A S KRL ID
Sbjct: 62 LLGEAIKPF-KDKVVVASKFGIYYADPNDKYATMFLDSSPNRIKSAIEGSLKRLKVECID 120
Query: 118 LYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQV 177
LY H DT I E ++ L+ EG I+ G+S L + Q+A + + Q
Sbjct: 121 LYYQH-RMDTNTPIGEVAEVMQLLIKEGKIKAWGMSEAGLSSI---QKAHQICPLSALQS 176
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI------------------------- 212
+YSL R PE+ +L ++++E I +A++PL KG
Sbjct: 177 EYSLWWREPEKE-ILGFLEKEKIGFVAFSPLGKGFLGAKFEKNATFASEDFRSVSPRFNQ 235
Query: 213 --LARNKCLAEIGKRY----GKTSAQVALNYLIWEENVVAIPKASNKD-HIKENFGAMGW 265
LA+N L E+ + + G T AQ+AL++++ + ++ + K+ + EN GA+
Sbjct: 236 ENLAKNYALVELIQDHAHAKGVTPAQLALSWILHTQKIIVPLFGTTKESRLIENIGALQV 295
Query: 266 RLSREDRE 273
S+++ E
Sbjct: 296 SWSQKELE 303
>pir||T27575 hypothetical protein ZC443.1 - Caenorhabditis elegans
>gi|3881394|emb|CAA99947.1| (Z75553) Similarity to Human
aldose reductase (SW:ALDR_HUMAN), contains similarity to
Pfam domain: PF00248 (Aldo/keto reductase family),
Score=508.9, E-value=1.2e-149, N=1 [Caenorhabditis
elegans]
Length = 343
Score = 82.7 bits (201), Expect = 4e-15
Identities = 81/302 (26%), Positives = 133/302 (43%), Gaps = 53/302 (17%)
Query: 6 AKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG 65
+KV F + +IG+GTW + G+E +R + G IDTA Y
Sbjct: 3 SKVPIFTLSNGVLMPSIGLGTWQMTGEE---------GKTVIRNAVLAGYRHIDTATLY- 52
Query: 66 AGHSEELVGKAI-----EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDL 118
+E +G A+ EG RE+IFI +K + + ++A R S KRL Y+DL
Sbjct: 53 --QNEHQIGDALAELFAEGILKREDIFITTKAFCHEVAPDVVEEALRNSLKRLRLDYVDL 110
Query: 119 YLLHWPGDTWK--------KIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKY 170
YL H P T K+E+ E++ GL + IGVSNF+ + R ++K
Sbjct: 111 YLAHIPASTKDDGSFRSDVKVEDIWRGFEKVYGLGLTKAIGVSNFNESQIVRIMN-IQKV 169
Query: 171 EIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAY----TPLEKGILARN---------- 216
I +Q++ L P++ + K+ I + AY +P ++ N
Sbjct: 170 PIHASQLELHLY--LPQKAHR-ELCKKHNILITAYATLGSPGRMSVVGSNGRPLFESTQN 226
Query: 217 -------KCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSR 269
K + + ++Y KT AQ+ L + E ++ IPK +N + +KEN + +S
Sbjct: 227 SENEMNDKHVKALAQKYSKTPAQILLRATV-EMGIIVIPKTTNPERMKENINIFDFNISN 285
Query: 270 ED 271
+
Sbjct: 286 AE 287
>gb|AAF54731.1| (AE003694) CG3397 gene product [Drosophila melanogaster]
Length = 342
Score = 82.7 bits (201), Expect = 4e-15
Identities = 68/205 (33%), Positives = 110/205 (53%), Gaps = 27/205 (13%)
Query: 10 DFKRIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAG 67
+++++G +V+ I +G + K F D E I ++ + GIN IDTA FYG G
Sbjct: 23 EYRQLGSTGLRVSKIALGGATLS-KLFSDDFDREEGILTVQEAIRSGINYIDTAPFYGQG 81
Query: 68 HSEELVGKAIEGFNREEIFIVSKVW-----PTH-FGYESAKKAARASAKRLGTY-----I 116
SEEL+G+A++ RE +I +KV P + F Y +AK AR S KR +
Sbjct: 82 KSEELLGQALKDVPREAYYIATKVARYELDPNNMFDYTAAK--ARESVKRSLELLQLDRV 139
Query: 117 DLYLLHWPGDTWKKIE----ETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMR-KYE 171
D+ +H D ++ ET+ LEE V G R+IGV+ +D+++L+ E + + +
Sbjct: 140 DVLQVH-DVDAAPSLDMVLNETIPVLEEYVQAGKARFIGVTAYDVDVLKECAERGKGRIQ 198
Query: 172 IVVNQVKYSLMDRTPEETGLLDYMK 196
+V+N +Y+L+D T LL +MK
Sbjct: 199 VVLNYARYTLLDNT-----LLRHMK 218
>gi|10954651 similar to ydbC gene in Escherichia coli [Agrobacterium rhizogenes]
>gi|10567315|dbj|BAB16124.1| (AP002086) similar to ydbC
gene in Escherichia coli [Agrobacterium rhizogenes]
Length = 295
Score = 81.9 bits (199), Expect = 8e-15
Identities = 75/271 (27%), Positives = 124/271 (45%), Gaps = 27/271 (9%)
Query: 12 KRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEE 71
KR+ G WG P KD ++ LR + LG N IDTAEFYG S +
Sbjct: 20 KRMSYGTTQLPGPHVWG------PPRDKDA-ALAVLREAIALGANHIDTAEFYGPHVSNQ 72
Query: 72 LVGKAIEGFNREEIFIVSKV---------WPTHFGYESAKKAARASAKRLG----TYIDL 118
L+ +A+ + ++ +V+K+ W E+ ++A + LG ++L
Sbjct: 73 LIREALAPY-PSDLALVTKIGFERGEDGSWFPDRTPETLRRAVHENLSSLGLEALDVVNL 131
Query: 119 YLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVK 178
L G + E L L EL +GL+R+IG+S + EA + IV Q +
Sbjct: 132 RLGGPHGPDENSVAEPLGVLVELQRKGLVRHIGLSTVS---PAQFAEAEKMAPIVCVQNE 188
Query: 179 YSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAEIGKRYGKTSAQVALNYL 238
Y+L+ R + +D + +G+ + Y PL ++ L+ + G + QVAL +L
Sbjct: 189 YNLVRR--GDDAFIDELAAKGVAYVPYFPLGGFTPLQSSLLSSVADELGASPKQVALAWL 246
Query: 239 IWEE-NVVAIPKASNKDHIKENFGAMGWRLS 268
+ N++ I S+ DH+++NF A LS
Sbjct: 247 LQRSPNILVIAGTSSVDHLRQNFAAADLVLS 277
>emb|CAA12646.1| (AJ225806) potassium channel beta subunit [Egeria densa]
Length = 328
Score = 81.1 bits (197), Expect = 1e-14
Identities = 61/218 (27%), Positives = 106/218 (47%), Gaps = 20/218 (9%)
Query: 11 FKRIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGH 68
+K +G +V+ + G+W G + D + + ++ R + G+N D AE Y G
Sbjct: 3 YKNLGRSGLRVSQLSYGSWVSFGNQV-DVKEAKALLQCCR---DHGVNFFDNAEVYANGR 58
Query: 69 SEELVGKAIE--GFNREEIFIVSKVW-----PTHFGY--ESAKKAARASAKRLGT-YIDL 118
+EE++G+A G+ R ++ + +K++ P G + + RAS KRL Y+D+
Sbjct: 59 AEEIMGQAFRELGWKRSDLVVSTKIFWGGPGPNDKGLSRKHVVEGLRASLKRLDMDYVDI 118
Query: 119 YLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIV---VN 175
H P D IEET+ A+ ++D G Y G S + + + A ++V V
Sbjct: 119 VYCHRP-DASTPIEETVRAMNHVIDRGWAFYWGTSEWSSQQITEPWAAAENLDLVGPIVE 177
Query: 176 QVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGIL 213
Q +Y+L+ R E L ++ GI L ++PL G+L
Sbjct: 178 QPEYNLLSRHKVEAEYLPLYEKYGIGLTTWSPLASGVL 215
>pir||D82644 sugar-phosphate dehydrogenase XF1723 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9106791|gb|AAF84532.1|AE003996_1 (AE003996)
sugar-phosphate dehydrogenase [Xylella fastidiosa]
Length = 362
Score = 80.8 bits (196), Expect = 2e-14
Identities = 91/311 (29%), Positives = 142/311 (45%), Gaps = 55/311 (17%)
Query: 10 DFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGA--- 66
++K +G T + + +G F + + + S + L+ G+NL DTA+ YG
Sbjct: 35 NYKHLGR---TGLKVSRIALGCMNFGELTDEPNSFRIMSEALDSGVNLFDTADVYGGPQT 91
Query: 67 -------GHSEELVGK--AIEGFNREEIFIVSKVW-PTHFG----YESA---KKAARASA 109
G SEE +G+ A + R+ I + +KV+ P G Y SA ++A AS
Sbjct: 92 PDMEKGFGTSEEYIGRWLAQDKSRRDRIVLATKVYQPMGTGPNDKYLSAYHIRRACEASL 151
Query: 110 KRLGT-YIDLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQ---E 165
KRL T +IDLY +H D +E A+E+LV EG I Y+G SNF + R+Q E
Sbjct: 152 KRLKTDHIDLYQMHHV-DRSTPWQEIWQAMEQLVREGKITYVGSSNFAAWDIARAQGVAE 210
Query: 166 AMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGIL------------ 213
+ +V Q Y+L+ RT E ++ ++ GI L+ ++P+ G+L
Sbjct: 211 SRNFLGLVSEQSLYNLIQRT-IELEVIPAVRELGIGLIPWSPIGMGLLGGVLGKITEGRR 269
Query: 214 ARNKCLAEIGK-------------RYGKTSAQVALNYLIWEENV-VAIPKASNKDHIKEN 259
A A+I K G+ A VAL ++I V AI + ++EN
Sbjct: 270 ATPGLQAQIQKFRPQLEAYEALCRELGQPPAVVALAWVIHNPVVTAAISGPRTVEQMREN 329
Query: 260 FGAMGWRLSRE 270
A+ LS E
Sbjct: 330 LKALSLNLSSE 340
>gb|AAD39334.1|AC007258_23 (AC007258) Putative Aldo/keto reductase [Arabidopsis thaliana]
Length = 327
Score = 80.8 bits (196), Expect = 2e-14
Identities = 75/254 (29%), Positives = 120/254 (46%), Gaps = 38/254 (14%)
Query: 51 LELGINLIDTAEFYGAGHSEELVGKAIEGF-------NREEIFIVSKVWPTHFGYESAKK 103
++LG DT+ Y +EE +G+A+ +R E+F+ SK+W
Sbjct: 48 IKLGYRHFDTSPRY---QTEEPLGEALAEAVSLGLIQSRSELFVTSKLWCADAHGGLVVP 104
Query: 104 AARASAKRLGT-YIDLYLLHWP-----GDTWKKIEE----------TLHALEELVDEGLI 147
A + S + L Y+DLYL+HWP G IEE +EE G+
Sbjct: 105 AIQRSLETLKLDYLDLYLIHWPVSSKPGKYKFPIEEDDFLPMDYETVWSEMEECQRLGVA 164
Query: 148 RYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTP 207
+ IGVSNF + L+ ++ K VNQV+ M ++ L + K +GI + AY+
Sbjct: 165 KCIGVSNFSCKKLQHIL-SIAKIPPSVNQVE---MSPVWQQRKLRELCKSKGIVVTAYSV 220
Query: 208 L-EKGI------LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENF 260
L +G + + L EI + GKT AQV++ + +EE V + K+ KD ++EN
Sbjct: 221 LGSRGAFWGTHKIMESDVLKEIAEAKGKTVAQVSMRWA-YEEGVSMVVKSFRKDRLEENL 279
Query: 261 GAMGWRLSREDRER 274
W L+ E+++R
Sbjct: 280 KIFDWSLTEEEKQR 293
>gb|AAG19415.1| (AE005035) probable oxidoreductase; YajO2 [Halobacterium sp. NRC-1]
Length = 336
Score = 79.6 bits (193), Expect = 4e-14
Identities = 69/226 (30%), Positives = 108/226 (47%), Gaps = 29/226 (12%)
Query: 11 FKRIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGL-----ELGINLIDTAEF 63
F ++GD + +A+ GTW G + S D E E + L + G IDTA+
Sbjct: 11 FVQLGDTGLQTSALQFGTWRFGKRT---ESGDLEISEQRAHDLLDTYADAGGRYIDTADV 67
Query: 64 YGAGHSEELVGKAIEGFNREEIFIVSKV-WPTHFGYESAKKAARASAK--------RLGT 114
YG G SE +G + +R+ I SK+ W G +++ R + + RLGT
Sbjct: 68 YGGGDSERWIGDWLSDRDRDRYTIASKIYWQVRDGDPNSRGTNRKTIRNRITALLDRLGT 127
Query: 115 -YID-LYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLR--RSQEAMRK- 169
Y+D LY+ W GDT + E + L +LV +GL+ Y+G S R R+ E R
Sbjct: 128 EYLDVLYIHRWDGDTTAR--ELMRTLNDLVADGLVHYLGASTLQPNAWRIARANELARAE 185
Query: 170 --YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGIL 213
V Q +Y+L+DR E L + + +G+ + ++PL +G L
Sbjct: 186 GWEPFSVLQPRYNLVDR-EIEGDYLTFAREQGLAVCPWSPLAQGFL 230
>pir||H72391 K+ channel, beta subunit - Thermotoga maritima (strain MSB8)
>gi|4980814|gb|AAD35401.1|AE001713_5 (AE001713) K+
channel, beta subunit [Thermotoga maritima]
Length = 319
Score = 79.2 bits (192), Expect = 5e-14
Identities = 55/218 (25%), Positives = 107/218 (48%), Gaps = 18/218 (8%)
Query: 10 DFKRIGD--DKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAG 67
+++++G K++ + +G+W GK+ + + E ++ GIN DTAE Y G
Sbjct: 2 EYRKVGKWGVKISELSLGSWLTFGKQLDLDT----ATEVVKKAFNSGINFFDTAEAYAGG 57
Query: 68 HSEELVGKAIEGFNREEIFIVSKVW-----PTHFGYESAK--KAARASAKRLG-TYIDLY 119
+E ++GK ++ F RE++ + +K++ P G + S KRL Y+D+
Sbjct: 58 IAEAMLGKILKNFRREDLVVSTKIFWGGSGPNDLGLSKKHLLEGTWNSLKRLQMDYVDIL 117
Query: 120 LLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEI---VVNQ 176
H P D +EE + A++ ++ EGL Y G S + + + + ++ + +V Q
Sbjct: 118 YCHRP-DPNVPMEEVVFAMDYILREGLALYWGTSEWSAKEIEEAHRVCKELGVMPPIVEQ 176
Query: 177 VKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA 214
+Y++ R E ++ G+ L Y+PL G+L+
Sbjct: 177 PQYNMFVRERVEKEYAPLYEKYGMGLTTYSPLASGLLS 214
>gb|AAC25601.1| (AF074484) xylose reductase [Candida tenuis]
Length = 322
Score = 78.8 bits (191), Expect = 7e-14
Identities = 86/322 (26%), Positives = 143/322 (43%), Gaps = 71/322 (22%)
Query: 6 AKVSDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG 65
A + D K + +IG G W + + + E + ++ G L D AE YG
Sbjct: 3 ASIPDIKLSSGHLMPSIGFGCWKLA---------NATAGEQVYQAIKAGYRLFDGAEDYG 53
Query: 66 AGHSEELVGKAI-----EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDL 118
+E+ VG + EG REEIF+ SK+W + ++ + A + L Y+DL
Sbjct: 54 ---NEKEVGDGVKRAIDEGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDL 110
Query: 119 YLLHWP--------------------GDTW----KKIEETLHALEELVDEGLIRYIGVSN 154
+L+H+P G+ + I ET ALE+LV G I+ IGVSN
Sbjct: 111 FLIHFPIAFKFVPIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSN 170
Query: 155 FD----LELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYT---- 206
F L+LLR + + V QV++ + P+ L+++ ++ G+T+ AY+
Sbjct: 171 FPGALLLDLLRGA-----TIKPAVLQVEHHPYLQQPK---LIEFAQKAGVTITAYSSFGP 222
Query: 207 ----------PLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHI 256
L L + + I +Y KT A+V L + + + IPK++ + +
Sbjct: 223 QSFVEMNQGRALNTPTLFAHDTIKAIAAKYNKTPAEVLLRWAA-QRGIAVIPKSNLPERL 281
Query: 257 KENFGAMGWRLSRED-RERAKL 277
+N + L++ED E AKL
Sbjct: 282 VQNRSFNTFDLTKEDFEEIAKL 303
>gb|AAD41821.1|AF147704_1 (AF147704) NDP-hexose 2,3-enoyl reductase TylCII [Streptomyces
fradiae]
Length = 329
Score = 78.8 bits (191), Expect = 7e-14
Identities = 65/217 (29%), Positives = 106/217 (47%), Gaps = 24/217 (11%)
Query: 15 GDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYG----AGHSE 70
G V+ + +GT G+ D ++I + L+ G+N +DTA+ YG GH+E
Sbjct: 11 GATLVSRLWLGTVNFSGRV-----PDDQAIRLMDEALDRGVNCVDTADIYGWRLYKGHTE 65
Query: 71 ELVGKAIEGFNREEIFIVS---------KVWPTHFGYESAKKAARASAKRLGT-YIDLYL 120
ELVG+ + G R + +++ +V ++ AS +RLG +IDLY
Sbjct: 66 ELVGRWLRGSGRRDDVVLATKVGEPMSDRVNDRGLSARHVIRSCEASLRRLGVDHIDLYQ 125
Query: 121 LHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRK---YEIVVNQV 177
+H D + +E A+++LV G +RYIG SNF L QE+ + +V Q
Sbjct: 126 MHRM-DRTVRWDELWQAMDQLVASGKVRYIGSSNFAGWHLAAGQESAARRGSLGLVSEQC 184
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILA 214
Y+L R E +L + GI + A++PL G+L+
Sbjct: 185 LYNLAVR-HAELEVLPAARAYGIGVFAWSPLHGGLLS 220
>pir||T35344 probable oxidoreductase - Streptomyces coelicolor
>gi|4835331|emb|CAB42953.1| (AL049863) putative
oxidoreductase [Streptomyces coelicolor A3(2)]
Length = 305
Score = 78.4 bits (190), Expect = 9e-14
Identities = 78/284 (27%), Positives = 129/284 (44%), Gaps = 30/284 (10%)
Query: 14 IGDDKVTAIGMGTWGIGGK---EFPDYSKDRESIEALRYGLELGINLIDTAEFYGAG--H 68
+GD V +G G + G S S+ LR +ELG+N IDTA FY +
Sbjct: 22 LGDLPVRRVGFGAMRLTGSAAFHLGTPSDRARSLAVLRRAVELGVNHIDTAAFYFSSLRS 81
Query: 69 SEELVGKAIEGFNREEIFIVSKV---------WPTHFGYESAKKAARASAKRLG-TYID- 117
+ EL+ A+ + +++ I +KV W T E + + ++LG ++D
Sbjct: 82 ANELINSALAPY-ADDLVIATKVGPYRDWSGEWGTSARPEDLRAHVEENLRQLGRDHLDV 140
Query: 118 LYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQV 177
+YL D+ + E AL EL GLIR++G+S + R EA ++ Q
Sbjct: 141 VYLRRMRQDS---VAEHFGALAELRAAGLIRHLGLSGVE---PRHLAEAQAIAPVMSVQN 194
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPL--EKGI----LARNKCLAEIGKRYGKTSA 231
+Y L P LL + +GI + + + E G A + + + + +G +SA
Sbjct: 195 RYGLGFHDPATDALLAQCRAQGIAFVPFYAIAGEAGPRGAGTAHEEEVRAVARAHGASSA 254
Query: 232 QVALNYLIWE-ENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
QV + + + + +V+A+P N DH+ EN A RL+ D R
Sbjct: 255 QVRIAWTLHQGPHVLAVPGTGNPDHLAENVAAGALRLTGADLAR 298
>emb|CAB62709.1| (AL133423) putative aldo/keto reductase [Streptomyces coelicolor
A3(2)]
Length = 338
Score = 78.4 bits (190), Expect = 9e-14
Identities = 72/224 (32%), Positives = 112/224 (49%), Gaps = 24/224 (10%)
Query: 13 RIGDD--KVTAIGMGTWGIGGKEFPDYSKDRESIEA-LRYGLELGINLIDTAEFYGAGHS 69
R+G D +V A G+G G+ P D E+ A L LELG+ L DTA+ YGAG +
Sbjct: 10 RLGTDGPEVGAQGLGCMGMSFAYGPT---DTEASRATLERALELGVTLYDTADAYGAGEN 66
Query: 70 EELVGKAIEGFNREEIFIVSKVW-------PTHFGYES----AKKAARASAKRLG-TYID 117
E + + +R+E+ + +K PT + ++A AS +RL ID
Sbjct: 67 ERFLAPFFKA-HRDEVVVATKFALSIPPDDPTKRIIRNDAPYIREAVEASLRRLDLDVID 125
Query: 118 LYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQV 177
LY +H D IEET+ + +LV EG ++ +G+S + LR +Q + I Q
Sbjct: 126 LYYMH-RRDVNVPIEETVAVMADLVREGKVKQLGLSEVTGDELRAAQTV---HPIAAVQS 181
Query: 178 KYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGILARNKCLAE 221
++SL R E G++ + G+TL+ Y+PL +G L + AE
Sbjct: 182 EWSLFSR-DIEAGVVPAARELGVTLVPYSPLGRGFLTGSFANAE 224
>gb|AAF86345.1|AF278715_1 (AF278715) xylose reductase [Candida shehatae]
Length = 323
Score = 78.4 bits (190), Expect = 9e-14
Identities = 84/312 (26%), Positives = 137/312 (42%), Gaps = 70/312 (22%)
Query: 11 FKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSE 70
FK ++ +IG G W + D + ++ G L D AE YG +E
Sbjct: 9 FKLNNGLEMPSIGFGCWKLDKSTAADQVYN---------AIKAGYRLFDGAEDYG---NE 56
Query: 71 ELVGKAI-----EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHW 123
+ VG+ + EG REEIF+ SK+W + ++ + A + K L Y+DL+L+H+
Sbjct: 57 QEVGEGVKRAIDEGIVTREEIFLTSKLWNNYHDPKNVETALNKTLKDLKVDYVDLFLIHF 116
Query: 124 P--------------------GDTWK----KIEETLHALEELVDEGLIRYIGVSNFD--- 156
P GD + I ET ALE+LV G IR IGVSNF
Sbjct: 117 PIAFKFVPIEEKYPPGFYCGDGDNFVYEDVPILETWKALEKLVKAGKIRSIGVSNFPGAL 176
Query: 157 -LELLRRSQEAMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYT--------- 206
L+L R + + V QV++ + P+ L++Y ++ GIT+ AY+
Sbjct: 177 LLDLFRGA-----TIKPAVLQVEHHPYLQQPK---LIEYAQKVGITVTAYSSFGPQSFVE 228
Query: 207 -----PLEKGILARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFG 261
L L + + I ++ K A+V L + + + IPK++ + + +N
Sbjct: 229 MNQGRALNTPTLFEHDVIKAIAAKHNKVPAEVLLRWSA-QRGIAVIPKSNLPERLVQNRS 287
Query: 262 AMGWRLSREDRE 273
+ L++ED E
Sbjct: 288 FNDFELTKEDFE 299
>pir||T44623 aldehyde reductase homolog [imported] - Butyrivibrio fibrisolvens
(fragment) >gi|1622731|gb|AAC44492.1| (U44893) AkrI
[Butyrivibrio fibrisolvens]
Length = 172
Score = 78.0 bits (189), Expect = 1e-13
Identities = 55/156 (35%), Positives = 79/156 (50%), Gaps = 21/156 (13%)
Query: 13 RIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEEL 72
RI + TAI M +G G + D + E+ ++R L+ G IDTA FY +E+
Sbjct: 7 RIKLNNGTAIPM--FGYGTYKIKDQN---EAYNSVRLALKNGYRHIDTAAFY---ENEKF 58
Query: 73 VGKAIEGF------NREEIFIVSKVWPTHFGYESAKKAARASAKRLG-TYIDLYLLHWPG 125
V AI+ F RE+IF+ SK W T GY+ A + + Y+DLYL+HWP
Sbjct: 59 VANAIKDFMEESQTKREDIFVTSKAWKTELGYDKTLAAFEKTMNEMQMDYLDLYLVHWPA 118
Query: 126 -----DTWKKI-EETLHALEELVDEGLIRYIGVSNF 155
D W+ +T A+ E+ G ++ IGVSNF
Sbjct: 119 SYAFDDDWENTNRQTWKAMTEIYKSGRVKAIGVSNF 154
>gi|6320079 Ydl124wp [Saccharomyces cerevisiae] >gi|2131342|pir||S67667
hypothetical protein YDL124w - yeast (Saccharomyces
cerevisiae) >gi|1431185|emb|CAA98692.1| (Z74172) ORF
YDL124w [Saccharomyces cerevisiae]
Length = 312
Score = 76.5 bits (185), Expect = 3e-13
Identities = 78/276 (28%), Positives = 134/276 (48%), Gaps = 31/276 (11%)
Query: 19 VTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLEL-GINLIDTAEFYGAGHSEELVGKAI 77
+ IG GT +E D + +E + Y L+L GI ID AE Y + VGKA+
Sbjct: 19 IAIIGTGTRWYKNEE-TDATFSNSLVEQIVYALKLPGIIHIDAAEIY---RTYPEVGKAL 74
Query: 78 EGFN--REEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWPGDTWK----K 130
R IF+ K P +S + K++GT Y+DLYLLH P + +
Sbjct: 75 SLTEKPRNAIFLTDKYSPQIKMSDSPADGLDLALKKMGTDYVDLYLLHSPFVSKEVNGLS 134
Query: 131 IEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEIVVNQVKYS--LMDRTPEE 188
+EE +E+L G + IGVSNF +E L+R + + + + VNQ+++S L ++TP
Sbjct: 135 LEEAWKDMEQLYKSGKAKNIGVSNFAVEDLQRILK-VAEVKPQVNQIEFSPFLQNQTP-- 191
Query: 189 TGLLDYMKREGITLMAYTPLEKGILARN----------KCLAEIGKRYGKTSAQVALNYL 238
G+ + + I + AY+PL G L + + + E+ ++Y K+ AQ+ L +
Sbjct: 192 -GIYKFCQEHDILVEAYSPL--GPLQKKTAQDDSQPFFEYVKELSEKYIKSEAQIILRW- 247
Query: 239 IWEENVVAIPKASNKDHIKENFGAMGWRLSREDRER 274
+ + V+ + +S I + + L+ E+ ++
Sbjct: 248 VTKRGVLPVTTSSKPQRISDAQNLFSFDLTAEEVDK 283
>gb|AAK40755.1| Oxidoreductase [Sulfolobus solfataricus]
Length = 354
Score = 73.7 bits (178), Expect = 2e-12
Identities = 71/286 (24%), Positives = 125/286 (42%), Gaps = 41/286 (14%)
Query: 11 FKRIGDDKVTA--IGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGH 68
++RIGD +T IG+G W + + + E I +R E+GIN DTA+ YG G
Sbjct: 31 YRRIGDTNITVSEIGIGVWSLVTDWWGADTNKAEDI--IRRAYEVGINFYDTADTYGEGK 88
Query: 69 SEELVGKAIEGFNREEIFIVSKVWPTHFGYESAK-----------KAARASAKRLGT-YI 116
EE++ K +E R+ I I++K+ + E K A + S +RL T YI
Sbjct: 89 GEEIIAKVLE-TKRDNIVILTKIGYDFYHKEGGKIRQRFDIPYLEFALKRSLERLRTDYI 147
Query: 117 DLYLLHWPGDTWKKIEETLHALEELVDEGLIRYIGVS--------NFDLELLRRSQEAMR 168
D+ ++H P K E L L L +G+IR GV+ +E + E++
Sbjct: 148 DILMIHNPKMNAIKNLEILSFLRSLKKDGIIRMYGVALGPTLGWEEEGIEAINMGYESLE 207
Query: 169 KYEIVVNQ------VKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGI---------L 213
++ Q +KY + D + + L++ L + + +
Sbjct: 208 YIYNIIEQRPGNKFLKYEKVGHIIRVPHASDVLNEDKWPLISDPKLHRSLKDIKWLNEGI 267
Query: 214 ARNKCLAEIGKRYGKTSAQVALNYLIWEENV-VAIPKASNKDHIKE 258
R+ L E G T + +AL +++ +NV IP ++ + +++
Sbjct: 268 KRSLKLKEFASSKGMTLSDLALKFILSNKNVSTVIPNITSINELEK 313
>emb|CAA98021.1| (Z73640) 4-Dihydromethyl-trisporate dehydrogenase [Mucor mucedo]
Length = 321
Score = 73.7 bits (178), Expect = 2e-12
Identities = 82/301 (27%), Positives = 128/301 (42%), Gaps = 61/301 (20%)
Query: 17 DKVTAIGMGTWGIGGKEFPDYSKDRESIEALRYGLELGINLIDTAEFYGAGHSEELVGKA 76
DK+ G G W I +KD E E + ++ G L D A YG +E VG+
Sbjct: 13 DKMPIRGFGCWKID-------TKDCE--ETVYQAIKTGYRLFDGACDYG---NEVEVGRG 60
Query: 77 I-----EGF-NREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP----- 124
I EG RE++FIV+K+W T + + K G Y DLYL+H+P
Sbjct: 61 INKAINEGLVKREDLFIVTKLWNTFHSKKHVRALFDRQLKDTGLEYFDLYLIHFPVPLQY 120
Query: 125 -------------GDT------WKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQE 165
GD I E LE++VD GL R IGV+NF+ + + +
Sbjct: 121 VDPATVYPPGWYVGDAKSLQFEQSPIHECWAELEKIVDAGLARNIGVANFNCQAI---LD 177
Query: 166 AMRKYEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL---------EKG----I 212
+ I ++ L P+E L+ ++K +GI + AY+ E G
Sbjct: 178 LLTYARIKPAVLQIELHPYLPQER-LVKWVKEQGIQITAYSSFGPTSYVDLTESGKTYTS 236
Query: 213 LARNKCLAEIGKRYGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSREDR 272
L + + + ++ ++ QV L + + E V IPK+ N +K N + +L ED
Sbjct: 237 LLEHASVKSVADKHNVSTGQVLLRWALDREFAV-IPKSVNAGRMKANLEILDIKLDAEDN 295
Query: 273 E 273
+
Sbjct: 296 K 296
>emb|CAB76977.1| (AL159178) putative oxidoreductase [Streptomyces coelicolor A3(2)]
Length = 285
Score = 73.7 bits (178), Expect = 2e-12
Identities = 84/284 (29%), Positives = 132/284 (45%), Gaps = 27/284 (9%)
Query: 9 SDFKRIGDDKVTAIGMGTWGIGGKEFPDYSKDRESIEA-LRYGLELGINLIDTAEFY--- 64
+DF+ GD + +G G + F ++D E+ A LR +ELGI+ IDTA FY
Sbjct: 3 NDFRLGGDLPIGRLGFGAMRLPTNSFHGPARDPETGRAVLRRAVELGIDHIDTAAFYTSD 62
Query: 65 -GAGHSEELVGKAIEGFNREEIFIVSKVWPTHF---GYESAKK--AARASAKR----LGT 114
G+ + +L+ +A+ + + + I +KV P G E+ A RA + LG
Sbjct: 63 DGSVRANDLIREALHPY-PDGLVIATKVGPLRTPDGGLEATTDPGALRALVEENLAGLGV 121
Query: 115 -YIDLYLLH----WPGDTWKKIEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRK 169
+DL L P + + AL L +EGLIR++G+S+ D L ++ A+
Sbjct: 122 DRLDLVYLRIGGIEPPPHGESVAARFEALAALREEGLIRHLGLSHVDAGHLAEAR-AIAP 180
Query: 170 YEIVVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPLEKGIL-ARNKCLAEIGKRYGK 228
V N D +T +L + GI + Y PL G+ +AE+ R+G
Sbjct: 181 VAAVQNHFHPDRRD----DTEVLARCEEAGIAYVPYFPLGGGLADIGGGRVAEVADRHGA 236
Query: 229 TSAQVALNYLIWEENV-VAIPKASNKDHIKENFGAMGWRLSRED 271
T Q+AL L+ V +AIP + H++EN A L+ ED
Sbjct: 237 TVPQIALARLLASSPVTLAIPGTGSVAHLEENTAAGSIVLTAED 280
>dbj|BAB11492.1| (AB015469) aldose reductase-like protein [Arabidopsis thaliana]
Length = 316
Score = 72.6 bits (175), Expect = 5e-12
Identities = 78/286 (27%), Positives = 127/286 (44%), Gaps = 49/286 (17%)
Query: 17 DKVTAIGMGTWGIGGKEFPDYSKDRES-IEALRYGLELGINLIDTAEFYGAGHSEELVGK 75
+ + +GMGT+ KDRES I A+ +++G DTA+ YG SEE +G
Sbjct: 12 ETIPLLGMGTYCP--------QKDRESTISAVHQAIKIGYRHFDTAKIYG---SEEALGT 60
Query: 76 AIEG------FNREEIFIVSKVWPTHFGYESAKKAARASAKRLGT-YIDLYLLHWP---- 124
A+ R+++F+ SK+W + + A + K +G Y+D YL+HWP
Sbjct: 61 ALGQAISYGTVQRDDLFVTSKLWSSD--HHDPISALIQTLKTMGLDYLDNYLVHWPIKLK 118
Query: 125 ---------GDTWKK---IEETLHALEELVDEGLIRYIGVSNFDLELLRRSQEAMRKYEI 172
D ++K IEET +E ++ GL R IGVSNF + + +
Sbjct: 119 PGVSEPIPKEDEFEKDLGIEETWQGMERCLEMGLCRSIGVSNFSSKKIFDLLD-FASVSP 177
Query: 173 VVNQVKYSLMDRTPEETGLLDYMKREGITLMAYTPL-------EKGILARNKCLAEIGKR 225
VNQV+ + R + L + I + Y+PL + + + I +
Sbjct: 178 SVNQVEMHPLWR---QRKLRKVCEENNIHVSGYSPLGGPGNCWGSTAVIEHPIIKSIALK 234
Query: 226 YGKTSAQVALNYLIWEENVVAIPKASNKDHIKENFGAMGWRLSRED 271
+ T AQVAL + + + I K+ N + EN A+ +L +D
Sbjct: 235 HNATPAQVALRWGM-SKGASVIVKSFNGARMIENKRALEIKLDDQD 279
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.137 0.406
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104453104
Number of Sequences: 2977
Number of extensions: 4247532
Number of successful extensions: 16248
Number of sequences better than 1.0e-10: 310
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 302
Number of HSP's that attempted gapping in prelim test: 15238
Number of HSP's gapped (non-prelim): 325
length of query: 279
length of database: 189,106,746
effective HSP length: 54
effective length of query: 225
effective length of database: 156,788,448
effective search space: 35277400800
effective search space used: 35277400800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 164 (68.3 bits)