BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2347 (nadC) DE:nicotinate-nucleotide pyrophosphorylase
(nadC)
(279 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75185 nicotinate-nucleotide pyrophosphorylase (nadc) PAB23... 534 e-151
pir||H71218 probable nicotinate-nucleotide pyrophosphorylase - P... 466 e-130
gi|11499424 nicotinate-nucleotide pyrophosphorylase (nadC) [Arch... 256 2e-67
sp|O27860|NADC_METTH PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 252 2e-66
sp|Q57916|NADC_METJA PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 248 5e-65
gb|AAK41267.1| Nicotinate-nucleotide pyrophosphorylase [Sulfolob... 242 3e-63
pir||B70375 quinolinate phosphoribosyl transferase - Aquifex aeo... 205 5e-52
gb|AAG20081.1| (AE005087) quinolinate phosphoribosyltransferase;... 193 2e-48
pir||B82621 nicotinate-mononucleotide pyrophosphorylase XF1925 [... 182 4e-45
pir||B72227 nicotinate-nucleotide pyrophosphorylase - Thermotoga... 178 5e-44
sp|P39666|NADC_BACSU PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 178 6e-44
pir||D81204 nicotinate-nucleotide pyrophosphorylase NMB0396 [imp... 177 1e-43
pir||A81780 nicotinate-nucleotide pyrophosphorylase (carboxylati... 176 2e-43
pir||D47071 orf2 3' of nadB - Bacillus subtilis (fragment) 173 2e-42
dbj|BAB04938.1| (AP001511) nicotinate-nucleotide pyrophosphoryla... 169 2e-41
sp|P77938|NADC_RHORU PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 166 3e-40
sp|P30011|NADC_ECOLI NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CA... 157 1e-37
pdb|1QAP|A Chain A, Quinolinic Acid Phosphoribosyltransferase Wi... 155 4e-37
sp|P30012|NADC_SALTY NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CA... 155 5e-37
emb|CAB89834.1| (AJ242516) NadC protein [Salmonella typhimurium] 155 5e-37
pir||S68368 quinolinate phosphoribosyltransferase - Escherichia ... 155 6e-37
gi|7657488 quinolinate phosphoribosyltransferase; nicotinate-nuc... 154 1e-36
pir||T36392 nicotinate-nucleotide pyrophophorylase - Streptomyce... 152 4e-36
sp|Q9ZJN2|NADC_HELPJ PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 149 4e-35
pir||G83080 nicotinate-nucleotide pyrophosphorylase PA4524 [impo... 149 4e-35
dbj|BAA92153.1| (AB038494) quinolinate phosphoribosyltransferase... 148 5e-35
sp|O06594|NADC_MYCTU NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CA... 148 8e-35
pdb|1QPO|A Chain A, Quinolinate Phosphoribosyl Transferase (Qapr... 148 8e-35
sp|O25909|NADC_HELPY PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 147 1e-34
sp|P46714|NADC_MYCLE PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 146 2e-34
emb|CAB59429.1| (AJ243436) quinolinate phosphoribosyltransferase... 146 3e-34
gb|AAD14535.1| (AC006200) putative nicotinate-nucleotide pyropho... 146 3e-34
pir||T50961 probable nicotinate-nucleotide pyrophosphorylase (c... 145 4e-34
gi|6321162 Yfr047cp [Saccharomyces cerevisiae] >gi|1171637|sp|P4... 145 6e-34
pir||F82077 nicotinate-nucleotide pyrophosphorylase, carboxylati... 143 2e-33
emb|CAB59430.1| (AJ243437) quinolinate phosphoribosyltransferase... 143 3e-33
gb|AAF13762.1|AF117351_19 (AF117351) molybdenum transport system... 136 2e-31
gb|AAD03555.1| (AF095748) phthalate-inducible quinolinate phosph... 136 4e-31
gb|AAC99834.1| (U27709) nicotinate-nucleotide pyrophosphorylase ... 131 9e-30
sp|P74301|NADC_SYNY3 PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHOR... 122 5e-27
sp|Q08384|MODD_RHOCA MOLYBDENUM TRANSPORT SYSTEM PROTEIN MODD >g... 111 1e-23
pir||B36914 probable nicotinate-nucleotide pyrophosphorylase (c... 111 1e-23
sp|Q57278|MODD_HAEIN MOLYBDENUM TRANSPORT SYSTEM PROTEIN MODD HO... 103 3e-21
sp|P94777|MODD_ECOLI MOLYBDENUM TRANSPORT SYSTEM PROTEIN MODD HO... 74 2e-12
gb|AAC61710.1| (AF081283) molybdenum transport protein [Escheric... 73 3e-12
>pir||G75185 nicotinate-nucleotide pyrophosphorylase (nadc) PAB2347 - Pyrococcus
abyssi (strain Orsay) >gi|5457443|emb|CAB48934.1|
(AJ248283) nicotinate-nucleotide pyrophosphorylase
(nadC) [Pyrococcus abyssi]
Length = 279
Score = 534 bits (1360), Expect = e-151
Identities = 279/279 (100%), Positives = 279/279 (100%)
Query: 1 MIPLNYLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVS 60
MIPLNYLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVS
Sbjct: 1 MIPLNYLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVS 60
Query: 61 VSVKKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNP 120
VSVKKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNP
Sbjct: 61 VSVKKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNP 120
Query: 121 NVKVAGTRKSLLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRRAKEFSM 180
NVKVAGTRKSLLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRRAKEFSM
Sbjct: 121 NVKVAGTRKSLLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRRAKEFSM 180
Query: 181 YKVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGIT 240
YKVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGIT
Sbjct: 181 YKVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGIT 240
Query: 241 PNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIKRGSSS 279
PNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIKRGSSS
Sbjct: 241 PNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIKRGSSS 279
>pir||H71218 probable nicotinate-nucleotide pyrophosphorylase - Pyrococcus
horikoshii >gi|3256396|dbj|BAA29079.1| (AP000001) 283aa
long hypothetical nicotinate-nucleotide
pyrophosphorylase [Pyrococcus horikoshii]
Length = 283
Score = 466 bits (1187), Expect = e-130
Identities = 236/273 (86%), Positives = 259/273 (94%)
Query: 1 MIPLNYLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVS 60
+IPL YLL+F+ ED+PYGDVTSEAIIPEDM AEAVIIAKQDGVIAGVEEA+VLFEHFGV
Sbjct: 4 VIPLEYLLRFVYEDSPYGDVTSEAIIPEDMNAEAVIIAKQDGVIAGVEEARVLFEHFGVK 63
Query: 61 VSVKKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNP 120
V+V K+DGE V+ GEVI E+KGNARAILLVERTALNI+GRMSGIATETRKLVEKV++VNP
Sbjct: 64 VNVLKKDGEYVKKGEVIAEVKGNARAILLVERTALNIIGRMSGIATETRKLVEKVRKVNP 123
Query: 121 NVKVAGTRKSLLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRRAKEFSM 180
VKVAGTRKSLLRLIDK+AIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAI+RAKEFS+
Sbjct: 124 RVKVAGTRKSLLRLIDKRAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIKRAKEFSV 183
Query: 181 YKVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGIT 240
YKVVEVEVE+LEDA+KAAKAGAD+IMLDNMKPQEI VIE+L+ LGLR+ +KIEVSGGIT
Sbjct: 184 YKVVEVEVENLEDAVKAAKAGADVIMLDNMKPQEIKEVIEKLRELGLRDGVKIEVSGGIT 243
Query: 241 PNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
P NIEEYAKLDVDVISLGYLTHSV+NFDVSLEI
Sbjct: 244 PENIEEYAKLDVDVISLGYLTHSVRNFDVSLEI 276
>gi|11499424 nicotinate-nucleotide pyrophosphorylase (nadC) [Archaeoglobus
fulgidus] >gi|3122422|sp|O28439|NADC_ARCFU PROBABLE
NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|7449672|pir||F69479
nicotinate-nucleotide pyrophosphorylase (nadC) homolog -
Archaeoglobus fulgidus >gi|2648709|gb|AAB89414.1|
(AE000976) nicotinate-nucleotide pyrophosphorylase
(nadC) [Archaeoglobus fulgidus]
Length = 258
Score = 256 bits (647), Expect = 2e-67
Identities = 135/261 (51%), Positives = 186/261 (70%), Gaps = 9/261 (3%)
Query: 16 PYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGEEVRAGE 75
PYGDVT+ IP + EAVI++K +GV+AGV K+LF+ + V K+DGE ++ G+
Sbjct: 2 PYGDVTA---IPTK-DVEAVIVSKGEGVLAGVGVVKILFDLAEIVVMESKKDGEPIKPGD 57
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
V++ L+G + +IL ER A+NI+ RMSGIAT T K+VE+ +RVNP V VA TRK+ R
Sbjct: 58 VVMRLRGKSDSILATERLAINILMRMSGIATATAKMVERARRVNPKVVVAATRKTTPGFR 117
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYKVVEVEVESLE 192
+ +K A+ IGGG+ HRFSLSD +++KDNH+A+ LE A++ + F+ K +EVEV S+
Sbjct: 118 IFEKMAVEIGGGDAHRFSLSDCLMLKDNHIAVAGSLERAMKVKRSFT--KKLEVEVGSVG 175
Query: 193 DAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
DAIKAA+ GADIIMLDN P+ + +EEL+R GLRE + IEVSG +TP N+ E+A +DV
Sbjct: 176 DAIKAAEFGADIIMLDNFTPEMVAEAVEELRRRGLREKVIIEVSGSVTPENVAEFAAMDV 235
Query: 253 DVISLGYLTHSVKNFDVSLEI 273
DVIS GY+THS D SL +
Sbjct: 236 DVISSGYITHSAPALDFSLRV 256
>sp|O27860|NADC_METTH PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|7449671|pir||A69112
quinolinate phosphoribosyltransferase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622966|gb|AAB86298.1| (AE000936) quinolinate
phosphoribosyltransferase [Methanobacterium
thermoautotrophicum]
Length = 279
Score = 252 bits (638), Expect = 2e-66
Identities = 128/275 (46%), Positives = 196/275 (70%), Gaps = 4/275 (1%)
Query: 4 LNYLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSV 63
++ + + I D + D+T+EA+I A I+++++GV+AGVE A+++ F +S+
Sbjct: 2 MDIIREMIRADVGFEDITTEALIDRGTRVVADIVSREEGVVAGVEVAEMMAREFSISIIR 61
Query: 64 KKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVK 123
K DG+ + GE +L L+G+A IL+VERT LN+M +MSGIAT TR ++++ + VN ++
Sbjct: 62 WKDDGDPLSGGERVLTLEGDAMDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNEGIR 121
Query: 124 VAGTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVP-LEEAIRRAKEF-S 179
+A TRK+ L+ +K+A+ IGGG+ HRF L D +IKDNH+A+V +E+A+RR ++ S
Sbjct: 122 IAATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKDNHIAIVGNIEDAVRRVRDHVS 181
Query: 180 MYKVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGI 239
K VEVEVES +DA++AA+AGADI++LDNM P+ I +EEL+R GLR+N+ +E SGGI
Sbjct: 182 FTKKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEELERRGLRDNVIVEASGGI 241
Query: 240 TPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIK 274
P+NIE YA V+VIS+G++T S D+SLEI+
Sbjct: 242 KPDNIELYASTGVEVISMGFITASAHPVDLSLEIR 276
>sp|Q57916|NADC_METJA PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|2129160|pir||E64361
nicotinate-nucleotide pyrophosphorylase (carboxylating)
(EC 2.4.2.19) - Methanococcus jannaschii
>gi|1591197|gb|AAB98483.1| (U67499)
nicotinate-nucleotide pyrophosphorylase (nadC)
[Methanococcus jannaschii]
Length = 283
Score = 248 bits (627), Expect = 5e-65
Identities = 138/277 (49%), Positives = 190/277 (67%), Gaps = 7/277 (2%)
Query: 4 LNYLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSV 63
L L K +E D +GD+T+ +IIPE ++A+ VI AK+ ++ G++ FE +G+
Sbjct: 7 LKILKKSLEYDVGFGDITTNSIIPEGVKAKGVIKAKEKCIVCGIDFIVAFFEEYGIKCKK 66
Query: 64 KKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVK 123
DGEE ILE +G+AR IL++ERTALN++ +SGIAT T ++V+K K VN NV+
Sbjct: 67 LFNDGEEAYGN--ILEFEGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVNKNVR 124
Query: 124 VAGTRKS--LLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRRAKE-FSM 180
VA TRK+ LL + K A+ IGGG+ HRF L D +LIKDNH+A+V ++EAIRRAKE S
Sbjct: 125 VACTRKTLPLLSPLQKYAVYIGGGDTHRFRLDDCVLIKDNHIAIVGVKEAIRRAKENVSF 184
Query: 181 YKVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIK--IEVSGG 238
K +EVEV +L++ +A + ADIIMLDN KP+EI ++ + + N K IEVSGG
Sbjct: 185 TKKIEVEVSNLKELREALEERADIIMLDNFKPEEIEEALKIIDEFERKTNFKPIIEVSGG 244
Query: 239 ITPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIKR 275
I +NI EYAK +VDVIS+G LTHSVK+ D+SL+I R
Sbjct: 245 IKEDNILEYAKYNVDVISMGALTHSVKSVDMSLDIVR 281
>gb|AAK41267.1| Nicotinate-nucleotide pyrophosphorylase [Sulfolobus solfataricus]
Length = 275
Score = 242 bits (612), Expect = 3e-63
Identities = 130/273 (47%), Positives = 187/273 (67%), Gaps = 12/273 (4%)
Query: 7 LLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKR 66
LL ++EED D+T++ + E + A ++ K G++AG ++ G S ++
Sbjct: 10 LLDYLEEDVMPEDITTKFL--EGIRARGIVRCKDSGILAGNRFIVPFLKYLGFSNINGEK 67
Query: 67 DGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAG 126
DG EV+ G+++L +G+A IL VER LN +G++SGIAT T +V+K K VNP V++AG
Sbjct: 68 DGREVKKGDIVLNFEGDAD-ILTVERLILNFLGKLSGIATITNLMVKKAKEVNPYVRIAG 126
Query: 127 TRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVP-LEEAIRRAK-EFSMYK 182
TRK+ RL +K AI +GGG+PHR++LSDA+LIKDNH+ L LEE I+R K S K
Sbjct: 127 TRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHITLYGNLEELIKRVKFSVSFTK 186
Query: 183 VVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPN 242
++EVEV S EDAI+A KAGAD+I+LDNMKP EI+ ++ ELK + +E SGGITP+
Sbjct: 187 IIEVEVSSYEDAIRAFKAGADVILLDNMKPYEILPIVNELK-----SKVLLEASGGITPD 241
Query: 243 NIEEYAKLDVDVISLGYLTHSVKNFDVSLEIKR 275
N+ +YAK VDVIS GY+THS ++ D SL++++
Sbjct: 242 NVIDYAKTGVDVISSGYITHSYRSLDFSLDVEK 274
>pir||B70375 quinolinate phosphoribosyl transferase - Aquifex aeolicus
>gi|2983403|gb|AAC06987.1| (AE000711) quinolinate
phosphoribosyl transferase [Aquifex aeolicus]
Length = 274
Score = 205 bits (516), Expect = 5e-52
Identities = 122/271 (45%), Positives = 176/271 (64%), Gaps = 13/271 (4%)
Query: 7 LLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFG-VSVSVKK 65
L +F+ ED GD+T+E I + +A+AVI K++GV+AG +++FE G VSV KK
Sbjct: 10 LKEFLLEDIGTGDITTEGIYRGE-KAKAVIKTKEEGVLAGAPFVEMVFEILGGVSVEFKK 68
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
R+GE GE++ L+G+A+++L+ ER +LNI+ R+SGIAT RK VEK+K NVK+
Sbjct: 69 REGEVFEKGEILAILEGDAKSLLIGERLSLNILQRLSGIATTARKFVEKLK--GTNVKIL 126
Query: 126 GTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKE-FSMY 181
TRK+ R +K A+ IGGG HRF L D +LIKDNH + ++EA++R +E S
Sbjct: 127 DTRKTTPGFRYFEKYAVRIGGGTNHRFGLYDMVLIKDNHKRVAGSIKEAVKRVRERISPV 186
Query: 182 KVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITP 241
+EVEVE+LE+ +A AG D+IMLDN P+E+ R +E +K L +EVSG IT
Sbjct: 187 YKIEVEVENLEEVEEALSAGVDVIMLDNFTPEEVKRAVEIIKGRAL-----VEVSGNITL 241
Query: 242 NNIEEYAKLDVDVISLGYLTHSVKNFDVSLE 272
+N+ +YA VD IS G + HS + D+SL+
Sbjct: 242 DNVLDYAVEGVDFISSGAIVHSSRWLDISLK 272
>gb|AAG20081.1| (AE005087) quinolinate phosphoribosyltransferase; NadC
[Halobacterium sp. NRC-1]
Length = 268
Score = 193 bits (485), Expect = 2e-48
Identities = 110/267 (41%), Positives = 166/267 (61%), Gaps = 16/267 (5%)
Query: 9 KFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDG 68
+++ ED + DVT++ +P E ++AKQ GV AG++ A +FE+ G G
Sbjct: 10 RWLREDLGHHDVTND--VPG--ETTGRLVAKQAGVAAGLDAAVRVFEYLGCEADAPAAAG 65
Query: 69 EEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTR 128
+ + AG+ +L + G A+++L ER A+N+ G SG+AT+TR+ V + + +V +AGTR
Sbjct: 66 DRIDAGDTVLRVSGAAQSVLRAERVAVNVAGHASGVATKTRRAVAAAREASDDVAIAGTR 125
Query: 129 KSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRR---AKEFSMYKV 183
K+ LR ++K+A++ GGG+ HR LS +++KDNH+A + LE AI R AK F+
Sbjct: 126 KTTPGLRGVEKRAVVAGGGDTHRLDLSHMVMVKDNHVAELGLEGAIERFRAAKSFA--TK 183
Query: 184 VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNN 243
++VEVE+ EDA +AA AGADI++LDNM P E R ++ L L E SGGIT ++
Sbjct: 184 LDVEVETPEDAPRAADAGADIVLLDNMTPAETERAVDLLDGAAL-----AEASGGITVDD 238
Query: 244 IEEYAKLDVDVISLGYLTHSVKNFDVS 270
+ YA VDVIS+G LTHS D+S
Sbjct: 239 VPAYAATGVDVISMGALTHSAPTLDLS 265
>pir||B82621 nicotinate-mononucleotide pyrophosphorylase XF1925 [imported] -
Xylella fastidiosa (strain 9a5c)
>gi|9107025|gb|AAF84731.1|AE004012_5 (AE004012)
nicotinate-mononucleotide pyrophosphorylase [Xylella
fastidiosa]
Length = 289
Score = 182 bits (457), Expect = 4e-45
Identities = 105/268 (39%), Positives = 161/268 (59%), Gaps = 13/268 (4%)
Query: 18 GDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKR--DGEEVRAGE 75
GD+TS A+IPE + +I+A+Q GVIAG++ A++ F+ + + + DG +V+ G+
Sbjct: 27 GDITSAAVIPEKHRSTVIIVARQSGVIAGLDTAELAFKVINAELVMMRHVHDGMKVKPGD 86
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
VI + G +RA+L ERTALN + +SGIAT T +V + V TRK+L +R
Sbjct: 87 VIATITGCSRALLTAERTALNFLSHLSGIATATASIVTAI--AGTKTVVVCTRKTLPGIR 144
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYKV-VEVEVESL 191
+ K A+ GGG HRF+L DA+LIKDNH+A+ + EA+R AK + + V +E+EV++L
Sbjct: 145 TLQKYAVRAGGGMNHRFALYDAMLIKDNHIAIAGSVREALRHAKAMAGHLVNIEIEVDTL 204
Query: 192 EDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKLD 251
E +A + G D ++LDNM+P E+ + + + E SG ITP A
Sbjct: 205 EQLHEAMEIGVDAVLLDNMQPSELREAVNIVAGRAI-----TEASGRITPETAINIAASG 259
Query: 252 VDVISLGYLTHSVKNFDVSLEIKRGSSS 279
VD+IS+G++THS D+ L+ K +SS
Sbjct: 260 VDLISVGWITHSAPILDIGLDFKSAASS 287
>pir||B72227 nicotinate-nucleotide pyrophosphorylase - Thermotoga maritima
(strain MSB8) >gi|4982219|gb|AAD36712.1|AE001807_3
(AE001807) nicotinate-nucleotide pyrophosphorylase
[Thermotoga maritima]
Length = 273
Score = 178 bits (448), Expect = 5e-44
Identities = 108/277 (38%), Positives = 166/277 (58%), Gaps = 13/277 (4%)
Query: 4 LNYLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIA-GVEEAKVLFEHFGVSVS 62
L+ L+ F++ED D+ S + + A A ++ K + V+A G+E +++ E G+
Sbjct: 5 LDLLMSFVKEDEGKLDLASFPL--RNTTAGAHLLLKTENVVASGIEVSRMFLEKMGLLSK 62
Query: 63 VKKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNV 122
DGE + VI E++GN +L+ ERT LN++ M +AT TR+ EK+K +
Sbjct: 63 FNVEDGEYLEGTGVIGEIEGNTYKLLVAERTLLNVLSVMFSVATTTRRFAEKLK----HA 118
Query: 123 KVAGTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFS 179
K+A TRK L L ++ K A++ GGG+PHR LS ++IKDNHL + E A++ ++
Sbjct: 119 KIAATRKILPGLGVLQKIAVVHGGGDPHRLDLSGCVMIKDNHLKMYGSAERAVQEVRKII 178
Query: 180 MYKV-VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGG 238
+ +EVEVE+LEDA++A +AGADI+MLDN+ P+E+ + +K + N+ +EVSGG
Sbjct: 179 PFTTKIEVEVENLEDALRAVEAGADIVMLDNLSPEEVKDISRRIK--DINPNVIVEVSGG 236
Query: 239 ITPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIKR 275
IT N+ Y VDVIS LT D+SLEI+R
Sbjct: 237 ITEENVSLYDFETVDVISSSRLTLQEVFVDLSLEIQR 273
>sp|P39666|NADC_BACSU PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) (GENERAL STRESS PROTEIN
70) (GSP70) >gi|7449665|pir||G69663
nicotinate-nucleotide pyrophosphorylase nadC - Bacillus
subtilis >gi|2635251|emb|CAB14746.1| (Z99118)
nicotinate-nucleotide pyrophosphorylase [Bacillus
subtilis]
Length = 289
Score = 178 bits (447), Expect = 6e-44
Identities = 114/276 (41%), Positives = 166/276 (59%), Gaps = 14/276 (5%)
Query: 10 FIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVS--VKKRD 67
F ED GD+TS++I E EA I+AK +G+ AG K F +V + K+D
Sbjct: 13 FFLEDIGTGDLTSQSIFGEQ-SCEAEIVAKSEGIFAGAAIIKEGFSLLDENVQSILHKKD 71
Query: 68 GEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGT 127
G+ + GEVI EL G A A+L ER LN++ R+SGIAT TR+ V + + +K+ T
Sbjct: 72 GDMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLD--DEQIKICDT 129
Query: 128 RKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYKV- 183
RK+ LR+++K A+ GGG HRF L D I+IKDNH+A + EA ++A++ + + V
Sbjct: 130 RKTTPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVN 189
Query: 184 VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNN 243
+EVE+E+ E +A AGAD+IM DN P + VR +L NIK E SGGIT +
Sbjct: 190 IEVEIETEEQLREAIAAGADVIMFDNC-PPDTVRHFAKL----TPANIKTEASGGITLES 244
Query: 244 IEEYAKLDVDVISLGYLTHSVKNFDVSLEIKRGSSS 279
+ + V+ ISLG+LTHSVK+ D+S+++ + S
Sbjct: 245 LPAFKGTGVNYISLGFLTHSVKSLDISMDVTLSNES 280
>pir||D81204 nicotinate-nucleotide pyrophosphorylase NMB0396 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7225618|gb|AAF40836.1| (AE002395)
nicotinate-nucleotide pyrophosphorylase [Neisseria
meningitidis MC58]
Length = 293
Score = 177 bits (445), Expect = 1e-43
Identities = 102/260 (39%), Positives = 157/260 (60%), Gaps = 5/260 (1%)
Query: 18 GDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKK--RDGEEVRAGE 75
GD+TS A+I D A+ +++++DGVIAG++ A++ F+ SV + RDG+ VRAG+
Sbjct: 31 GDITSAAVIAPDKTAKLFLVSREDGVIAGMDLARLAFQTMDPSVRFQAEIRDGQAVRAGQ 90
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSLLRLI 135
+ ++GNARA+L ERTALN + +SGIAT T + V +V ++ + LLR++
Sbjct: 91 TLAAVEGNARALLAAERTALNYLTHLSGIATATARAVAEVAEYGTDIVCSRKTIPLLRVL 150
Query: 136 DKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKE-FSMYKVVEVEVESLED 193
K A+ GGG HR L DA+LIKDNHLA + +A+++AK+ VE+EV++L
Sbjct: 151 QKYAVRAGGGVNHRMGLDDAVLIKDNHLAYCGSIAQAVQQAKQAVGALTCVEIEVDTLAQ 210
Query: 194 AIKAAKAGADIIMLDNMKPQEIVRVIEEL-KRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
+A AGA+ I+LDNM + + + I E SGGI + ++ A+ V
Sbjct: 211 LDEAIAAGAERILLDNMDDETLKEAANRCHTQTAHPHTIYCEASGGIGFDRLKRVAQTGV 270
Query: 253 DVISLGYLTHSVKNFDVSLE 272
D I+LGYLTHS ++ D+ L+
Sbjct: 271 DGIALGYLTHSSRSLDIGLD 290
>pir||A81780 nicotinate-nucleotide pyrophosphorylase (carboxylating) (EC
2.4.2.19) NMA2088 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7380713|emb|CAB85304.1|
(AL162758) nicotinate-nucleotide pyrophosphorylase
[Neisseria meningitidis Z2491]
Length = 293
Score = 176 bits (443), Expect = 2e-43
Identities = 101/260 (38%), Positives = 156/260 (59%), Gaps = 5/260 (1%)
Query: 18 GDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKR--DGEEVRAGE 75
GD+TS A+I D A+ +++++DGVIAG++ A++ F+ SV + DG+ VRAG+
Sbjct: 31 GDITSAAVIAPDKTAKLFLVSREDGVIAGMDLARIAFQTMDPSVRFQAEIHDGQAVRAGQ 90
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSLLRLI 135
+ ++GNARA+L ERTALN + +SGIAT T + V +V + ++ + LLR++
Sbjct: 91 TLAAVEGNARALLAAERTALNYLTHLSGIATATARAVAEVAKYGTDIVCSRKTIPLLRVL 150
Query: 136 DKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKE-FSMYKVVEVEVESLED 193
K A+ GGG HR L DA+LIKDNHLA + +A+R+AK+ VE+EV++L
Sbjct: 151 QKYAVRAGGGVNHRMGLDDAVLIKDNHLAYCGSIAQAVRQAKQAVGPLTCVEIEVDTLAQ 210
Query: 194 AIKAAKAGADIIMLDNMKPQEIVRVIEEL-KRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
+A AGA I+LDNM + + + + E SGGI + ++ A+ V
Sbjct: 211 LDEAIAAGAKRILLDNMDDETLKEAANRCHTQTSHPHTVYCEASGGIGFDRLKRVAQTGV 270
Query: 253 DVISLGYLTHSVKNFDVSLE 272
D I+LGYLTHS ++ D+ L+
Sbjct: 271 DGIALGYLTHSSRSLDIGLD 290
>pir||D47071 orf2 3' of nadB - Bacillus subtilis (fragment)
Length = 270
Score = 173 bits (434), Expect = 2e-42
Identities = 112/266 (42%), Positives = 160/266 (60%), Gaps = 14/266 (5%)
Query: 10 FIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVS--VKKRD 67
F ED GD+TS++I E EA I+AK +G+ AG K F +V + K+D
Sbjct: 13 FFLEDIGTGDLTSQSIFGEQ-SCEAEIVAKSEGIFAGAAIIKEGFSLLDENVQSILHKKD 71
Query: 68 GEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGT 127
G+ + GEVI EL G A A+L ER LN++ R+SGIAT TR+ V + + +K+ T
Sbjct: 72 GDMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLD--DEQIKICDT 129
Query: 128 RKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYKV- 183
RK+ LR+++K A+ GGG HRF L D I+IKDNH+A + EA ++A++ + + V
Sbjct: 130 RKTTPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKARQAAGHMVN 189
Query: 184 VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNN 243
+EVE+E+ E +A AGAD+IM DN P + VR +L NIK E SGGIT +
Sbjct: 190 IEVEIETEEQLREAIAAGADVIMFDNC-PPDTVRHFAKL----TPANIKTEASGGITLES 244
Query: 244 IEEYAKLDVDVISLGYLTHSVKNFDV 269
+ + V+ ISLG+LTHSVK+ D+
Sbjct: 245 LPAFKGTGVNYISLGFLTHSVKSLDI 270
>dbj|BAB04938.1| (AP001511) nicotinate-nucleotide pyrophosphorylase [Bacillus
halodurans]
Length = 281
Score = 169 bits (425), Expect = 2e-41
Identities = 104/271 (38%), Positives = 160/271 (58%), Gaps = 13/271 (4%)
Query: 9 KFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKR-- 66
+F ED GD+T+ AI P + A + AK G+++G+ ++ + + V++R
Sbjct: 12 RFFLEDGFNGDITTTAIFPPSEKCVAHVKAKARGIVSGLSLLEIGYSLLDDHIHVEERVK 71
Query: 67 DGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAG 126
DG+EVR G+VI ++G +L ER LN++ RMSGIAT TRK ++ + +P++++
Sbjct: 72 DGQEVRPGDVIATIQGPVHHVLFGERVLLNLIQRMSGIATVTRKAIDTLN--DPSIRICD 129
Query: 127 TRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVP-LEEAIRRAKEFSMYKV 183
TRK+ L+L +K A+ GGG HR +LSD +LIKDNH+A + +A+ +A+ + +
Sbjct: 130 TRKTTPGLKLFEKYAVRSGGGYNHRLNLSDMVLIKDNHIAQAKGIRQAVTQARSVIGHSL 189
Query: 184 -VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPN 242
+EVEVE+ E +A AG DIIM DNM P +I+E L + + I E SGGI+
Sbjct: 190 KIEVEVENREQLEEAVDAGVDIIMFDNMPP----HIIKEYVAL-VPDGIVTEASGGISLQ 244
Query: 243 NIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
I Y VD +SLG++THS D +L I
Sbjct: 245 TIASYRGCGVDYLSLGFITHSAPILDFTLLI 275
>sp|P77938|NADC_RHORU PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|11280012|pir||T51326
nicotinate-nucleotide pyrophosphorylase (carboxylating)
(EC 2.4.2.19) [imported] - Rhodospirillum rubrum
>gi|1498753|gb|AAC45128.1| (U65510)
nicotinate-nucleotide pyrophosphorylase [Rhodospirillum
rubrum]
Length = 296
Score = 166 bits (416), Expect = 3e-40
Identities = 101/263 (38%), Positives = 154/263 (58%), Gaps = 14/263 (5%)
Query: 18 GDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFG--VSVSVKKRDGEEVRAGE 75
GD+TS A IP A A +A+Q G++AG+ A+ F V+ + DG E+ AG+
Sbjct: 31 GDITSTATIPAATRAHARFVARQPGILAGLGCARSAFALLDDTVTFTTPLEDGAEIAAGQ 90
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
+ E+ G AR IL ERTALN +G +SGIAT TR+ + + + ++ TRK+ LR
Sbjct: 91 TVAEVAGAARTILAAERTALNFLGHLSGIATRTRRFGDAI--AHTRARLTCTRKTTPGLR 148
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYKV-VEVEVESL 191
++K A+ GGG HRF L DA+LIKDNH+A+ + A+ RA+ + V +E+EV++L
Sbjct: 149 GLEKYAVRCGGGSNHRFGLDDAVLIKDNHIAVAGGVSAALSRARAGVGHMVRIEIEVDTL 208
Query: 192 EDAIKA-AKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKL 250
E + A GA++++LDNM + R ++ + + E SGG++ + I A+
Sbjct: 209 EQLAEVLAVGGAEVVLLDNMDAPTLTRAVDM-----VAGRLVTEASGGVSLDTIAALAES 263
Query: 251 DVDVISLGYLTHSVKNFDVSLEI 273
VD IS+G LTHSV D+ L+I
Sbjct: 264 GVDYISVGALTHSVTTLDIGLDI 286
>sp|P30011|NADC_ECOLI NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|7449664|pir||E64733
nicotinate-nucleotide pyrophosphorylase (carboxylating)
(EC 2.4.2.19) - Escherichia coli (strain K-12 substrain
MG1655) >gi|456041|gb|AAC36922.1| (L28105) quinolinate
phosphoribosyltransferase [Escherichia coli]
>gi|1786299|gb|AAC73220.1| (AE000120) quinolinate
phosphoribosyltransferase [Escherichia coli K12]
Length = 297
Score = 157 bits (394), Expect = 1e-37
Identities = 97/262 (37%), Positives = 155/262 (59%), Gaps = 14/262 (5%)
Query: 19 DVTSEAIIPEDMEAEAVIIAKQDGVIAG---VEEAKVLFEHFGVSVSVKKRDGEEVRAGE 75
D+T++ ++PE+ + A +I +++GV G VEE + V++ DG+ + A +
Sbjct: 44 DITAK-LLPENSRSHATVITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQ 102
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
+ EL+G +R +L ERTALN + +SG+A++ R VE ++ N ++ TRK+L LR
Sbjct: 103 SLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLE--GTNTQLLDTRKTLPGLR 160
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNH-LALVPLEEAIRRAKEFSMYKVVEVEVESLE 192
K A++ GGG HR LSDA LIK+NH +A + +A+ +A VEVEVE+LE
Sbjct: 161 SALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLE 220
Query: 193 DAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
+ +A KAGADIIMLDN + +++ ++ L +EVSG +T + E+A+ V
Sbjct: 221 ELDEALKAGADIIMLDNFETEQMREAVKRTNGKAL-----LEVSGNVTDKTLREFAETGV 275
Query: 253 DVISLGYLTHSVKNFDVSLEIK 274
D IS+G LT V+ D+S+ +
Sbjct: 276 DFISVGALTKHVQALDLSMRFR 297
>pdb|1QAP|A Chain A, Quinolinic Acid Phosphoribosyltransferase With Bound
Quinolinic Acid >gi|1941992|pdb|1QAP|B Chain B,
Quinolinic Acid Phosphoribosyltransferase With Bound
Quinolinic Acid
Length = 296
Score = 155 bits (389), Expect = 4e-37
Identities = 96/259 (37%), Positives = 150/259 (57%), Gaps = 14/259 (5%)
Query: 19 DVTSEAIIPEDMEAEAVIIAKQDGVIAG---VEEAKVLFEHFGVSVSVKKRDGEEVRAGE 75
D+T++ ++P D +A A +I ++DGV G VEE + V ++ DG+ + A +
Sbjct: 43 DITAQ-LLPADTQAHATVITREDGVFCGKRWVEEVFIQLAGDDVRLTWHVDDGDAIHANQ 101
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
+ EL+G AR +L ERTALN + +SG+A+E R+ V + ++ TRK+L LR
Sbjct: 102 TVFELQGPARVLLTGERTALNFVQTLSGVASEVRRYVGLL--AGTQTQLLDTRKTLPGLR 159
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNH-LALVPLEEAIRRAKEFSMYKVVEVEVESLE 192
K A++ GGG HR L+DA LIK+NH +A + +A+ +A VEVEVE+L+
Sbjct: 160 TALKYAVLCGGGANHRLGLTDAFLIKENHIIASGSVRQAVEKAFWLHPDVPVEVEVENLD 219
Query: 193 DAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
+ A KAGADIIMLDN ++ ++ + ++EVSG +T + E+A+ V
Sbjct: 220 ELDDALKAGADIIMLDNFNTDQMREAVKR-----VNGQARLEVSGNVTAETLREFAETGV 274
Query: 253 DVISLGYLTHSVKNFDVSL 271
D IS+G LT V+ D+S+
Sbjct: 275 DFISVGALTKHVRALDLSM 293
>sp|P30012|NADC_SALTY NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|415621|gb|AAA03225.1|
(L07292) quinolinate phosphoribosyltransferase
[Salmonella typhimurium]
Length = 297
Score = 155 bits (388), Expect = 5e-37
Identities = 96/259 (37%), Positives = 149/259 (57%), Gaps = 14/259 (5%)
Query: 19 DVTSEAIIPEDMEAEAVIIAKQDGVIAG---VEEAKVLFEHFGVSVSVKKRDGEEVRAGE 75
D+T++ ++P D +A A +I ++DGV G VEE + V ++ DG+ + A +
Sbjct: 44 DITAQ-LLPADTQAHATVITREDGVFCGKRWVEEVFIQLAGDDVRLTWHVDDGDAIHANQ 102
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
+ EL G AR +L ERTALN + +SG+A+E R+ V + ++ TRK+L LR
Sbjct: 103 TVFELNGPARVLLTGERTALNFVQTLSGVASEVRRYVGLL--AGTQTQLLDTRKTLPGLR 160
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNH-LALVPLEEAIRRAKEFSMYKVVEVEVESLE 192
K A++ GGG HR L+DA LIK+NH +A + +A+ +A VEVEVE+L+
Sbjct: 161 TALKYAVLCGGGANHRLGLTDAFLIKENHIIASGSVRQAVEKAFWLHPDVPVEVEVENLD 220
Query: 193 DAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
+ A KAGADIIMLDN ++ ++ + ++EVSG +T + E+A+ V
Sbjct: 221 ELDDALKAGADIIMLDNFNTDQMREAVKR-----VNGQARLEVSGNVTAETLREFAETGV 275
Query: 253 DVISLGYLTHSVKNFDVSL 271
D IS+G LT V+ D+S+
Sbjct: 276 DFISVGALTKHVRALDLSM 294
>emb|CAB89834.1| (AJ242516) NadC protein [Salmonella typhimurium]
Length = 311
Score = 155 bits (388), Expect = 5e-37
Identities = 96/259 (37%), Positives = 149/259 (57%), Gaps = 14/259 (5%)
Query: 19 DVTSEAIIPEDMEAEAVIIAKQDGVIAG---VEEAKVLFEHFGVSVSVKKRDGEEVRAGE 75
D+T++ ++P D +A A +I ++DGV G VEE + V ++ DG+ + A +
Sbjct: 58 DITAQ-LLPADTQAHATVITREDGVFCGKRWVEEVFIQLAGDDVRLTWHVDDGDAIHANQ 116
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
+ EL G AR +L ERTALN + +SG+A+E R+ V + ++ TRK+L LR
Sbjct: 117 TVFELNGPARVLLTGERTALNFVQTLSGVASEVRRYVGLL--AGTQTQLLDTRKTLPGLR 174
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNH-LALVPLEEAIRRAKEFSMYKVVEVEVESLE 192
K A++ GGG HR L+DA LIK+NH +A + +A+ +A VEVEVE+L+
Sbjct: 175 TALKYAVLCGGGANHRLGLTDAFLIKENHIIASGSVRQAVEKAFWLHPDVPVEVEVENLD 234
Query: 193 DAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
+ A KAGADIIMLDN ++ ++ + ++EVSG +T + E+A+ V
Sbjct: 235 ELDDALKAGADIIMLDNFNTDQMREAVKR-----VNGQARLEVSGNVTAETLREFAETGV 289
Query: 253 DVISLGYLTHSVKNFDVSL 271
D IS+G LT V+ D+S+
Sbjct: 290 DFISVGALTKHVRALDLSM 308
>pir||S68368 quinolinate phosphoribosyltransferase - Escherichia coli
>gi|310262|gb|AAB00467.1| (L20833) quinolinate
phosphoribosyl transferase [Escherichia coli]
Length = 297
Score = 155 bits (387), Expect = 6e-37
Identities = 96/262 (36%), Positives = 154/262 (58%), Gaps = 14/262 (5%)
Query: 19 DVTSEAIIPEDMEAEAVIIAKQDGVIAG---VEEAKVLFEHFGVSVSVKKRDGEEVRAGE 75
D+T++ ++PE+ + A +I +++GV G VEE + V++ DG+ + A +
Sbjct: 44 DITAK-LLPENSRSHATVITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQ 102
Query: 76 VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL--LR 133
+ EL+G +R +L E TALN + +SG+A++ R VE ++ N ++ TRK+L LR
Sbjct: 103 SLFELEGPSRVLLTGEPTALNFVQTLSGVASKVRHYVELLE--GTNTQLLDTRKTLPGLR 160
Query: 134 LIDKKAIMIGGGEPHRFSLSDAILIKDNHL-ALVPLEEAIRRAKEFSMYKVVEVEVESLE 192
K A++ GGG HR LSDA LIK+NH+ A + +A+ +A VEVEVE+LE
Sbjct: 161 SALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLE 220
Query: 193 DAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKLDV 252
+ +A KAGADIIMLDN + +++ ++ L +EVSG +T + E+A+ V
Sbjct: 221 ELDEALKAGADIIMLDNFETEQMREAVKRTNGKAL-----LEVSGNVTDKTLREFAETGV 275
Query: 253 DVISLGYLTHSVKNFDVSLEIK 274
D IS+G LT V+ D+S+ +
Sbjct: 276 DFISVGALTKHVQALDLSMRFR 297
>gi|7657488 quinolinate phosphoribosyltransferase; nicotinate-nucleotide
pyrophosphorylase (carboxylating) [Homo sapiens]
>gi|2499961|sp|Q15274|NADC_HUMAN NICOTINATE-NUCLEOTIDE
PYROPHOSPHORYLASE [CARBOXYLATING] (QUINOLINATE
PHOSPHORIBOSYLTRANSFERASE [DECARBOXYLATING]) (QAPRTASE)
>gi|11280017|pir||T46864 nicotinate-nucleotide
pyrophosphorylase (carboxylating) (EC 2.4.2.19)
[validated] - human >gi|1060907|dbj|BAA11242.1| (D78177)
quinolinate phosphoribosyl transferase [Homo sapiens]
Length = 297
Score = 154 bits (385), Expect = 1e-36
Identities = 94/270 (34%), Positives = 155/270 (56%), Gaps = 12/270 (4%)
Query: 10 FIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGE 69
++ ED P + A++ ++A + AK GV+AG +F VS +G
Sbjct: 22 WLREDCP--GLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGS 79
Query: 70 EVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRK 129
++ + E++G A +LL ER ALN + R SGIA+ VE + VAGTRK
Sbjct: 80 KLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRK 139
Query: 130 SL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVP---LEEAIRRAKEFSMYKV- 183
+ RL++K +++GG HR+ L +++KDNH +VP +E+A+R A++ + + +
Sbjct: 140 TTPGFRLVEKYGLLVGGAASHRYDLGGLVMLKDNH--VVPPGGVEKAVRAARQAADFALK 197
Query: 184 VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNN 243
VEVE SL++ ++AA+AGAD+++LDN KP+E+ LK ++ +E SGGIT +N
Sbjct: 198 VEVECSSLQEVVQAAEAGADLVLLDNFKPEELHPTATALK--AQFPSVAVEASGGITLDN 255
Query: 244 IEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
+ ++ +DVIS+G LT +V D SL++
Sbjct: 256 LPQFCGPHIDVISMGMLTQAVPALDFSLKL 285
>pir||T36392 nicotinate-nucleotide pyrophophorylase - Streptomyces coelicolor
>gi|4585613|emb|CAB40881.1| (AL049628)
nicotinate-nucleotide pyrophophorylase [Streptomyces
coelicolor A3(2)]
Length = 329
Score = 152 bits (380), Expect = 4e-36
Identities = 106/273 (38%), Positives = 151/273 (54%), Gaps = 18/273 (6%)
Query: 11 IEEDAPYG-DVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLF-----EHFGVSVSVK 64
I+ED G DVT+ A IPED A A A++ GV+AG+ A+ + + F V V+
Sbjct: 63 IQEDLAGGVDVTTVATIPEDAVATADFTAREAGVVAGLRVAEAVLSVVCTDEFEVERHVE 122
Query: 65 KRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKV 124
DG+ V G+ +L + R IL ER+ALN++ RMSGIA+ TR + + KV
Sbjct: 123 --DGDRVAEGQKLLSVTTRTRDILTAERSALNLLCRMSGIASATRAWADALD--GTKAKV 178
Query: 125 AGTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNH-LALVPLEEAIRRAKEFSMY 181
TRK+ LR ++K A+ GGG HR SLSDA L+KDNH +A + EA +E
Sbjct: 179 RDTRKTTPGLRGLEKFAVRCGGGVNHRMSLSDAALVKDNHVVAAGGVAEAFNAVRESFPE 238
Query: 182 KVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITP 241
+EVEV++L + AGAD+I+LDN P E EE L + +E SG +T
Sbjct: 239 VPIEVEVDTLHQLREVVDAGADLILLDNFTPDE----CEEAVAL-VAGRAALEASGRLTL 293
Query: 242 NNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIK 274
N + YA VD +++G LTHS D+ L+++
Sbjct: 294 TNAKAYAATGVDYLAVGALTHSSPILDIGLDLR 326
>sp|Q9ZJN2|NADC_HELPJ PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|7449668|pir||H71827
nicotinate-nucleotide pyrophosphorylase - Helicobacter
pylori (strain J99) >gi|4155874|gb|AAD06845.1|
(AE001550) NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE
[Helicobacter pylori J99]
Length = 273
Score = 149 bits (372), Expect = 4e-35
Identities = 93/267 (34%), Positives = 149/267 (54%), Gaps = 9/267 (3%)
Query: 11 IEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGEE 70
++ED +GD+ E ++ +D +A A + AKQ+GV +G + A L + G+ +D E
Sbjct: 11 LKEDLGHGDLF-ERVLEKDFKATAFVRAKQEGVFSGEKYALELLQMTGIECVQNIKDKER 69
Query: 71 VRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKS 130
+ + ++E++G+ +L +ERT LN++ SGIAT T + VE + +P V++ TRK+
Sbjct: 70 FKPKDTLMEIRGDFSMLLKIERTLLNLLQHSSGIATLTSRFVEALN--SPKVRLLDTRKT 127
Query: 131 --LLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRA-KEFSMYKVVEV 186
LLR+ +K +++ GG HR L DA+++KD HL V L+ + A K +E+
Sbjct: 128 RPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLKHVKDLKSFLTHARKNLPFTAKIEI 187
Query: 187 EVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEE 246
E ES E+A A AGADI+M DNM E + R + +E SG I+ +I
Sbjct: 188 ECESFEEAKNAMSAGADIVMCDNMSVGETKEI--AAYREAHYPFVLLEASGNISLESINA 245
Query: 247 YAKLDVDVISLGYLTHSVKNFDVSLEI 273
YAK VD IS+G L H D+ +++
Sbjct: 246 YAKSGVDAISVGALIHQATFIDMHMKM 272
>pir||G83080 nicotinate-nucleotide pyrophosphorylase PA4524 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9950766|gb|AAG07912.1|AE004866_6 (AE004866)
nicotinate-nucleotide pyrophosphorylase [Pseudomonas
aeruginosa]
Length = 282
Score = 149 bits (372), Expect = 4e-35
Identities = 99/268 (36%), Positives = 149/268 (54%), Gaps = 13/268 (4%)
Query: 11 IEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFG--VSVSVKKRDG 68
+ ED GD+T++ I P+ EAEA +I ++ IAG +F V V+ + DG
Sbjct: 21 LAEDVGGGDLTAQLIDPQ-REAEARVITREHATIAGRAWVDEVFRQVDPRVLVTWQVEDG 79
Query: 69 EEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTR 128
+ V +++ +LKG ARA+L ER+ALN + +SG AT ++ + V VK+ TR
Sbjct: 80 QRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLV--AGTAVKLLDTR 137
Query: 129 KSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYKVVE 185
K+L LRL K A+ GG HR L DA LIK+NH+A ++ AI A+ + K VE
Sbjct: 138 KTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIDRAIAEARRIAPGKPVE 197
Query: 186 VEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIE 245
VEVE+L++ +A +AGADI+MLD + ++ + K+E SGGI +
Sbjct: 198 VEVENLDELRQALEAGADIVMLDELSLDDMRTAVAL-----TAGRAKLEASGGINEGTLR 252
Query: 246 EYAKLDVDVISLGYLTHSVKNFDVSLEI 273
A+ VD IS+G LT V+ D+S+ +
Sbjct: 253 NIAETGVDYISIGTLTKDVRAVDLSMRL 280
>dbj|BAA92153.1| (AB038494) quinolinate phosphoribosyltransferase [Nicotiana
tabacum]
Length = 351
Score = 148 bits (371), Expect = 5e-35
Identities = 102/286 (35%), Positives = 153/286 (52%), Gaps = 25/286 (8%)
Query: 8 LKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVK--K 65
L E+ GDVT +A IP DME++A +AK+DG+IAG+ A+++F S+ V+
Sbjct: 56 LALSEDAGNLGDVTCKATIPLDMESDAHFLAKEDGIIAGIALAEMIFAEVDPSLKVEWYV 115
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
DG++V G +++GNA I++ ER LN M RMSGIAT T+++ + +
Sbjct: 116 NDGDKVHKGLKFGKVQGNAYNIVIAERVVLNFMQRMSGIATLTKEMADAAH----PAYIL 171
Query: 126 GTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-----PLEEAIRRAKEF 178
TRK+ LRL+DK A++IGGG+ HR L D ++IKDNH++ L+ + ++
Sbjct: 172 ETRKTAPGLRLVDKWAVLIGGGKNHRMGLFDMVMIKDNHISAAGGVGKALKSVDQYLEQN 231
Query: 179 SMYKVVEVEVESLE------DAIKAAKAGADIIMLDNM-----KPQEIVRVIEELKRLGL 227
+ VEVE ++E D K IMLDNM V +++E L +
Sbjct: 232 KLQIGVEVETRTIEEVREVLDYASQTKTSLTRIMLDNMVVPLSNGDIDVSMLKEAVEL-I 290
Query: 228 RENIKIEVSGGITPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
E SG +T + + + V IS G LTHSVK D+SL+I
Sbjct: 291 NGRFDTEASGNVTLETVHKIGQTGVTYISSGALTHSVKALDISLKI 336
>sp|O06594|NADC_MYCTU NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|7449666|pir||F70543
probable nicotinate-nucleotide pyrophosphatase -
Mycobacterium tuberculosis (strain H37RV)
>gi|2117241|emb|CAB09073.1| (Z95586) nadC [Mycobacterium
tuberculosis]
Length = 285
Score = 148 bits (369), Expect = 8e-35
Identities = 93/271 (34%), Positives = 145/271 (53%), Gaps = 12/271 (4%)
Query: 11 IEEDAPYG-DVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHF----GVSVSVKK 65
++ED YG DVT+ A +P A ++ ++ GV+AG++ A + G V +
Sbjct: 19 LDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVALLTLNEVLGTNGYRVLDRV 78
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
DG V GE ++ L+ R +L ERT LN++G +SGIAT T V+ V+ K+
Sbjct: 79 EDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATATAAWVDAVR--GTKAKIR 136
Query: 126 GTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYK 182
TRK+L LR + K A+ GGG HR L DA LIKDNH+A + +A+R + +
Sbjct: 137 DTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAGSVVDALRAVRNAAPDL 196
Query: 183 VVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPN 242
EVEV+SLE ++I+LDN + ++ +R + +E SGG++
Sbjct: 197 PCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQ--RRDSRAPTVMLESSGGLSLQ 254
Query: 243 NIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
YA+ VD +++G LTHSV+ D+ L++
Sbjct: 255 TAATYAETGVDYLAVGALTHSVRVLDIGLDM 285
>pdb|1QPO|A Chain A, Quinolinate Phosphoribosyl Transferase (Qaprtase) Apo-
Enzyme From Mycobacterium Tuberculosis
>gi|4139885|pdb|1QPO|B Chain B, Quinolinate
Phosphoribosyl Transferase (Qaprtase) Apo- Enzyme From
Mycobacterium Tuberculosis >gi|4139886|pdb|1QPO|C Chain
C, Quinolinate Phosphoribosyl Transferase (Qaprtase)
Apo- Enzyme From Mycobacterium Tuberculosis
>gi|4139887|pdb|1QPO|D Chain D, Quinolinate
Phosphoribosyl Transferase (Qaprtase) Apo- Enzyme From
Mycobacterium Tuberculosis >gi|4139888|pdb|1QPO|E Chain
E, Quinolinate Phosphoribosyl Transferase (Qaprtase)
Apo- Enzyme From Mycobacterium Tuberculosis
>gi|4139889|pdb|1QPO|F Chain F, Quinolinate
Phosphoribosyl Transferase (Qaprtase) Apo- Enzyme From
Mycobacterium Tuberculosis >gi|3891647|pdb|1QPR|A Chain
A, Quinolinate Phosphoribosyltransferase (Qaprtase) From
Mycobacterium Tuberculosis In Complex With Phthalate And
Prpcp >gi|3891648|pdb|1QPR|B Chain B, Quinolinate
Phosphoribosyltransferase (Qaprtase) From Mycobacterium
Tuberculosis In Complex With Phthalate And Prpcp
>gi|3891649|pdb|1QPR|C Chain C, Quinolinate
Phosphoribosyltransferase (Qaprtase) From Mycobacterium
Tuberculosis In Complex With Phthalate And Prpcp
>gi|3891650|pdb|1QPR|D Chain D, Quinolinate
Phosphoribosyltransferase (Qaprtase) From Mycobacterium
Tuberculosis In Complex With Phthalate And Prpcp
>gi|3891651|pdb|1QPR|E Chain E, Quinolinate
Phosphoribosyltransferase (Qaprtase) From Mycobacterium
Tuberculosis In Complex With Phthalate And Prpcp
>gi|3891652|pdb|1QPR|F Chain F, Quinolinate
Phosphoribosyltransferase (Qaprtase) From Mycobacterium
Tuberculosis In Complex With Phthalate And Prpcp
>gi|4139890|pdb|1QPQ|A Chain A, Structure Of Quinolinic
Acid Phosphoribosyltransferase From Mycobacterium
Tuberculosis: A Potential Tb Drug Target
>gi|4139891|pdb|1QPQ|B Chain B, Structure Of Quinolinic
Acid Phosphoribosyltransferase From Mycobacterium
Tuberculosis: A Potential Tb Drug Target
>gi|4139892|pdb|1QPQ|C Chain C, Structure Of Quinolinic
Acid Phosphoribosyltransferase From Mycobacterium
Tuberculosis: A Potential Tb Drug Target
>gi|4139893|pdb|1QPQ|D Chain D, Structure Of Quinolinic
Acid Phosphoribosyltransferase From Mycobacterium
Tuberculosis: A Potential Tb Drug Target
>gi|4139894|pdb|1QPQ|E Chain E, Structure Of Quinolinic
Acid Phosphoribosyltransferase From Mycobacterium
Tuberculosis: A Potential Tb Drug Target
>gi|4139895|pdb|1QPQ|F Chain F, Structure Of Quinolinic
Acid Phosphoribosyltransferase From Mycobacterium
Tuberculosis: A Potential Tb Drug Target
>gi|4139878|pdb|1QPN|A Chain A, Quinolinate
Phosphoribosyl Transferase From Mycobacterium
Tuberculosis In Complex With Ncnn >gi|4139879|pdb|1QPN|B
Chain B, Quinolinate Phosphoribosyl Transferase From
Mycobacterium Tuberculosis In Complex With Ncnn
>gi|4139880|pdb|1QPN|C Chain C, Quinolinate
Phosphoribosyl Transferase From Mycobacterium
Tuberculosis In Complex With Ncnn >gi|4139881|pdb|1QPN|D
Chain D, Quinolinate Phosphoribosyl Transferase From
Mycobacterium Tuberculosis In Complex With Ncnn
>gi|4139882|pdb|1QPN|E Chain E, Quinolinate
Phosphoribosyl Transferase From Mycobacterium
Tuberculosis In Complex With Ncnn >gi|4139883|pdb|1QPN|F
Chain F, Quinolinate Phosphoribosyl Transferase From
Mycobacterium Tuberculosis In Complex With Ncnn
Length = 284
Score = 148 bits (369), Expect = 8e-35
Identities = 93/271 (34%), Positives = 145/271 (53%), Gaps = 12/271 (4%)
Query: 11 IEEDAPYG-DVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHF----GVSVSVKK 65
++ED YG DVT+ A +P A ++ ++ GV+AG++ A + G V +
Sbjct: 18 LDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVALLTLNEVLGTNGYRVLDRV 77
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
DG V GE ++ L+ R +L ERT LN++G +SGIAT T V+ V+ K+
Sbjct: 78 EDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATATAAWVDAVR--GTKAKIR 135
Query: 126 GTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYK 182
TRK+L LR + K A+ GGG HR L DA LIKDNH+A + +A+R + +
Sbjct: 136 DTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAGSVVDALRAVRNAAPDL 195
Query: 183 VVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPN 242
EVEV+SLE ++I+LDN + ++ +R + +E SGG++
Sbjct: 196 PCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQ--RRDSRAPTVMLESSGGLSLQ 253
Query: 243 NIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
YA+ VD +++G LTHSV+ D+ L++
Sbjct: 254 TAATYAETGVDYLAVGALTHSVRVLDIGLDM 284
>sp|O25909|NADC_HELPY PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|7449669|pir||C64689
nicotinate-nucleotide pyrophosphorylase - Helicobacter
pylori (strain 26695) >gi|2314523|gb|AAD08397.1|
(AE000636) nicotinate-nucleotide pyrophosphorylase
(nadC) [Helicobacter pylori 26695]
Length = 273
Score = 147 bits (367), Expect = 1e-34
Identities = 95/276 (34%), Positives = 154/276 (55%), Gaps = 17/276 (6%)
Query: 6 YLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKK 65
+L + ++ED +GD+ E ++ +D +A A + AKQ+GV +G + A L E G+
Sbjct: 6 FLERALKEDLGHGDLF-ERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTI 64
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
+D E + + ++E++G+ +L VERT LN++ SGIAT T + VE + + V++
Sbjct: 65 KDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALN--SHKVRLL 122
Query: 126 GTRKS--LLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRA-KEFSMY 181
TRK+ LLR+ +K +++ GG HR L DA+++KD HL V L+ + A K
Sbjct: 123 DTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLPFT 182
Query: 182 KVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLREN----IKIEVSG 237
+E+E ES E+A A AGADI+M DN+ V+E + R+ + +E SG
Sbjct: 183 AKIEIECESFEEAKNAMNAGADIVMCDNLS------VLETKEIAAYRDAHYPFVLLEASG 236
Query: 238 GITPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
I+ +I YAK VD IS+G L H D+ +++
Sbjct: 237 NISLESINAYAKSGVDAISVGALIHQATFIDMHMKM 272
>sp|P46714|NADC_MYCLE PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|2145919|pir||S72696
nicotinate-nucleotide pyrophosphorylase (carboxylating)
(EC 2.4.2.19) nadC - Mycobacterium leprae
>gi|466784|gb|AAA17060.1| (U00010) nadC; quinolinate
phosphoribosyltransferase; Lepb1170_C1_168
[Mycobacterium leprae]
Length = 284
Score = 146 bits (366), Expect = 2e-34
Identities = 98/271 (36%), Positives = 151/271 (55%), Gaps = 12/271 (4%)
Query: 11 IEEDAPYG-DVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAK-VLFEHFGVS---VSVKK 65
+ ED YG D+T++A +P ++ ++ GVIAGV+ A VL E FGV V +
Sbjct: 18 LHEDLRYGLDITTQATVPAGTVVTGSMVPREPGVIAGVDVALLVLDEVFGVDGYRVLYRV 77
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
DG +++G+ +L ++ AR +L ERT LN++ MSGIAT T V+ V+ K+
Sbjct: 78 EDGARLQSGQPLLTVQAAARGLLTAERTMLNLVCHMSGIATVTVAWVDAVR--GTKAKIR 135
Query: 126 GTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-PLEEAIRRAKEFSMYK 182
TRK+L LR + K A+ +GGG HR L D LIKDNH+A V + +A+R + +
Sbjct: 136 DTRKTLPGLRALQKYAVRVGGGVNHRLGLGDTALIKDNHVAAVGSVVDALRAVRAAAPEL 195
Query: 183 VVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPN 242
EVEV+SLE ++I+LDN + ++ +R + +E SGG++
Sbjct: 196 PCEVEVDSLEQLDAMLAEEPELILLDNFPVWQTQVAVQ--RRDIRAPTVLLESSGGLSLE 253
Query: 243 NIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
N YA VD +++G LTHSV+ D+ L++
Sbjct: 254 NAAIYAGTGVDYLAVGALTHSVRILDIGLDL 284
>emb|CAB59429.1| (AJ243436) quinolinate phosphoribosyltransferase [Nicotiana
rustica]
Length = 351
Score = 146 bits (364), Expect = 3e-34
Identities = 101/286 (35%), Positives = 152/286 (52%), Gaps = 25/286 (8%)
Query: 8 LKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVK--K 65
L E+ GDVT +A IP DME++A +AK+DG+IAG+ A+++F S+ V+
Sbjct: 56 LALSEDAGNLGDVTCKATIPLDMESDAHFLAKEDGIIAGIALAEMIFAEVDPSLKVEWYV 115
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
DG++V G +++GNA I++ ER LN M RMS IAT T+++ + +
Sbjct: 116 NDGDKVHKGLKFGKVQGNAYNIVIAERVVLNFMQRMSVIATLTKEMADAAH----PAYIL 171
Query: 126 GTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-----PLEEAIRRAKEF 178
TRK+ LRL+DK A++IGGG+ HR L D ++IKDNH++ L+ + ++
Sbjct: 172 ETRKTAPGLRLVDKWAVLIGGGKNHRMGLFDMVMIKDNHISAAGGVGKALKSVDQYLEQN 231
Query: 179 SMYKVVEVEVESLEDA------IKAAKAGADIIMLDNM-----KPQEIVRVIEELKRLGL 227
+ VEVE ++E+ K IMLDNM V +++E L +
Sbjct: 232 KLQIGVEVETRTIEEVREVLEYASQTKTSLTRIMLDNMVVPLSNGDIDVSMLKEAVEL-I 290
Query: 228 RENIKIEVSGGITPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
E SG +T + E + V IS G LTHSVK D+SL+I
Sbjct: 291 NGRFDTEASGNVTLETVHEIGQTGVTYISSGALTHSVKALDISLKI 336
>gb|AAD14535.1| (AC006200) putative nicotinate-nucleotide pyrophosphorylase
[Arabidopsis thaliana]
Length = 323
Score = 146 bits (364), Expect = 3e-34
Identities = 108/282 (38%), Positives = 159/282 (56%), Gaps = 26/282 (9%)
Query: 11 IEEDAPY-GDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVK--KRD 67
+ EDA + GDVT A IP DME EA +AK+DG++AGV A ++FEH S+ V+ ++D
Sbjct: 34 LAEDAGHTGDVTCMATIPFDMEVEAYFLAKEDGIVAGVALADMIFEHVDPSLKVEWMRKD 93
Query: 68 GEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGT 127
G+ V G ++ GNA I++ ER LN M RMSGIAT T+ + + + T
Sbjct: 94 GDYVHKGLKFGKVSGNAHKIVVAERVLLNFMQRMSGIATLTKLMADAAS----PACILET 149
Query: 128 RKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHL-ALVPLEEAIRRAKEFSMYKVV 184
RK+ LRL+DK A++IGGG HR L D ++IKDNH+ A + A++ E+ K +
Sbjct: 150 RKTAPGLRLVDKWAVLIGGGRNHRMGLFDMVMIKDNHISAAGGIVNAVKSVDEYLKQKNL 209
Query: 185 EVEVESLEDAIKAAK------AGADI----IMLDNM-KPQEIVRV-IEELKRLGLRENIK 232
E++VE ++ K +G++ IMLDNM P E V + LK N +
Sbjct: 210 EMDVEVETRTLEEVKEVLEYASGSETRLTRIMLDNMVVPLENGDVDVTMLKDAVELINGR 269
Query: 233 IEVSGGITPNNIEEYAKLD-VDVISLGYLTHSVKNFDVSLEI 273
E + ++ +Y + D V++ SL LTHSVK D+SL+I
Sbjct: 270 FETEAML---HLRQYTRSDRVELHSLAALTHSVKALDISLKI 308
>pir||T50961 probable nicotinate-nucleotide pyrophosphorylase (carboxylating)
[imported] - Neurospora crassa
>gi|9367264|emb|CAB97281.1| (AL389890) probable
nicotinate-nucleotide pyrophosphorylase (carboxylating)
[Neurospora crassa]
Length = 304
Score = 145 bits (363), Expect = 4e-34
Identities = 96/272 (35%), Positives = 150/272 (54%), Gaps = 10/272 (3%)
Query: 10 FIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDG- 68
++ ED P DV + D A + K G++AGV +F+ G +V +G
Sbjct: 23 WLAEDTPSFDVGG--FVVGDAPRTATLWGKSQGILAGVPFFNEVFKQCGCTVEWHATEGC 80
Query: 69 -EEVRAGE-VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAG 126
E G+ + + G AR +L ER ALNI+ R SG+AT++R L+ ++ VAG
Sbjct: 81 HVETHGGKRALATVTGPARGLLEGERVALNILARCSGVATQSRHLLVNLRSAGYKGIVAG 140
Query: 127 TRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHL-ALVPLEEAIRRAKEFSMYKV 183
TRK+ RL++K +++GG + HR LS ++KDNH+ + + EA++ AK + +
Sbjct: 141 TRKTTPGFRLVEKYGMLVGGADTHRMDLSTMTMLKDNHVWSRGSITEAVKAAKAAGGFSL 200
Query: 184 -VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELK-RLGLRENIKIEVSGGITP 241
+EVEV+S E+A +A AGADIIMLDN + + LK R ++ +EVSGG+T
Sbjct: 201 KIEVEVQSEEEADEAIAAGADIIMLDNFTGEGVRVAARSLKERWAGKKQFLLEVSGGLTA 260
Query: 242 NNIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
+N E Y D+D++S + V + D SL+I
Sbjct: 261 DNAESYICHDIDILSTSSIHQGVPHVDFSLKI 292
>gi|6321162 Yfr047cp [Saccharomyces cerevisiae]
>gi|1171637|sp|P43619|NADC_YEAST PUTATIVE
NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|1084761|pir||S56302
hypothetical protein YFR047c - yeast (Saccharomyces
cerevisiae) >gi|836802|dbj|BAA09286.1| (D50617) YFR047C
[Saccharomyces cerevisiae] >gi|871946|dbj|BAA08013.1|
(D44597) unknown [Saccharomyces cerevisiae]
Length = 295
Score = 145 bits (362), Expect = 6e-34
Identities = 91/275 (33%), Positives = 156/275 (56%), Gaps = 13/275 (4%)
Query: 10 FIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGE 69
++ ED P D ++ D++ EA + KQDG++ GV A+ +F + V ++G
Sbjct: 21 WLSEDVPSFDFGGY-VVGSDLK-EANLYCKQDGMLCGVPFAQEVFNQCELQVEWLFKEGS 78
Query: 70 EVRAGE------VILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVK 123
+ + V+ ++ G A+ ILL ERTALNI+ R SGIAT + K++ +
Sbjct: 79 FLEPSKNDSGKIVVAKITGPAKNILLAERTALNILSRSSGIATASHKIISLARSTGYKGT 138
Query: 124 VAGTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHL-ALVPLEEAIRRAKEFSM 180
+AGTRK+ LR ++K ++++GG + HR+ LS +++KDNH+ A + A++ A+
Sbjct: 139 IAGTRKTTPGLRRLEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGSITNAVKNARAVCG 198
Query: 181 YKV-VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELK-RLGLRENIKIEVSGG 238
+ V +EVE S ++A +A +AGAD+IMLDN K + + LK + +++ +E SGG
Sbjct: 199 FAVKIEVECLSEDEATEAIEAGADVIMLDNFKGDGLKMCAQSLKNKWNGKKHFLLECSGG 258
Query: 239 ITPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
+ +N+EEY D+D+ S + D SL++
Sbjct: 259 LNLDNLEEYLCDDIDIYSTSSIHQGTPVIDFSLKL 293
>pir||F82077 nicotinate-nucleotide pyrophosphorylase, carboxylating VC2422
[imported] - Vibrio cholerae (group O1 strain N16961)
>gi|9656997|gb|AAF95565.1| (AE004312)
nicotinate-nucleotide pyrophosphorylase, carboxylating
[Vibrio cholerae]
Length = 296
Score = 143 bits (358), Expect = 2e-33
Identities = 97/264 (36%), Positives = 150/264 (56%), Gaps = 13/264 (4%)
Query: 16 PYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVK--KRDGEEVRA 73
P D+T+ ++IP D + A II ++ GV G A +F+ G VS++ +DG+ +
Sbjct: 40 PAADITA-SLIPADRISTATIITREAGVFCGQLWADEVFKQLGGQVSIEWHVQDGDTLTP 98
Query: 74 GEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL-- 131
+ + L G AR +L ER A+N + +SG AT T + V+++K ++ TRK++
Sbjct: 99 NQTLCTLTGPARILLTGERNAMNFIQTLSGCATATARYVQELK--GTQCRLLDTRKTIPG 156
Query: 132 LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHL-ALVPLEEAIRRAKEFSMYKVVEVEVES 190
LR K A+ GGG HR + DA LIK+NH+ A + +AI AK+ + K VEVE E+
Sbjct: 157 LRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGIRQAISTAKQLNPGKPVEVETET 216
Query: 191 LEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEEYAKL 250
L + +A AGADIIMLDN + ++ E ++ +E SG IT +N++E A+
Sbjct: 217 LAELEEAISAGADIIMLDNFS----LEMMREAVKIN-AGRAALENSGNITLDNLKECAET 271
Query: 251 DVDVISLGYLTHSVKNFDVSLEIK 274
VD IS+G LT +K D+S+ K
Sbjct: 272 GVDYISVGALTKHLKALDLSMRFK 295
>emb|CAB59430.1| (AJ243437) quinolinate phosphoribosyltransferase [Nicotiana
tabacum]
Length = 351
Score = 143 bits (356), Expect = 3e-33
Identities = 99/286 (34%), Positives = 151/286 (52%), Gaps = 25/286 (8%)
Query: 8 LKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVK--K 65
L E+ GDVT +A IP DME++A +AK+DG+IAG+ A+++F S+ V+
Sbjct: 56 LALSEDAGNLGDVTCKATIPVDMESDAHFLAKEDGIIAGIALAEMIFAEVDPSLKVEWYV 115
Query: 66 RDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVA 125
DG++V G +++GNA I++ ER LN M RMSGIAT T+++ + +
Sbjct: 116 NDGDKVHKGLKFGKVQGNAYNIVIAERVVLNFMQRMSGIATLTKEMADAAH----PAYIL 171
Query: 126 GTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV-----PLEEAIRRAKEF 178
TRK+ LRL+DK A++IGGG+ HR L D ++IKDNH++ L+ + ++
Sbjct: 172 ETRKTAPGLRLVDKWAVLIGGGKNHRMGLFDMVMIKDNHISAAGGVGKALKSVDQYLEQN 231
Query: 179 SMYKVVEVEVESLEDA------IKAAKAGADIIMLDNM-----KPQEIVRVIEELKRLGL 227
+ VEVE ++ + K IMLDNM V +++E L +
Sbjct: 232 KLQIGVEVETRTIAEVREVLEYASQTKTSLTRIMLDNMVVPLSNGDIDVSMLKEAVEL-I 290
Query: 228 RENIKIEVSGGITPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
E SG +T + + + V IS G LT SVK D+SL+I
Sbjct: 291 NGRFDTEASGNVTLETVHKIGQTGVTYISSGALTQSVKALDISLKI 336
>gb|AAF13762.1|AF117351_19 (AF117351) molybdenum transport system protein [Zymomonas mobilis]
Length = 289
Score = 136 bits (340), Expect = 2e-31
Identities = 82/248 (33%), Positives = 138/248 (55%), Gaps = 8/248 (3%)
Query: 13 EDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGEEVR 72
EDA YGD+T+ ++ +D A A+ + + + VEEA L + G S+ G
Sbjct: 25 EDAGYGDLTTRSLGIQDHPAHITFTARDEQIASSVEEAAALLKQLGASIDYAIPSGSRAL 84
Query: 73 AGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKS-- 130
+G ++LE K +A + L ++A ++M +GIAT T K+V K+++P V TRK+
Sbjct: 85 SGTLLLEAKASAGQLHLGWKSAQSLMEWSAGIATMTHKMVTLAKKISPMAVVGCTRKAPP 144
Query: 131 LLRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLE--EAIRRAKEFSMYKVVEVEV 188
L R + KA++ GGG HR +LS+ +L+ HL + + +AI R K+ + + + VEV
Sbjct: 145 LTRPLAVKAVLAGGGVMHRINLSETLLVFAEHLTFMNFDIGKAIGRLKQTAPERKITVEV 204
Query: 189 ESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENI-KIEVSGGITPNNIEEY 247
E++E A+ A+ DI+ L+ PQ++ + E LK ++I + +GGI P NI +Y
Sbjct: 205 ETIEQALTVAQFSPDILQLEKFTPQQLHHLHERLK---FFDHIPSLAAAGGINPENIADY 261
Query: 248 AKLDVDVI 255
+ D+I
Sbjct: 262 IEAGADII 269
>gb|AAD03555.1| (AF095748) phthalate-inducible quinolinate phosphoribosyl
transferase [Burkholderia cepacia]
Length = 281
Score = 136 bits (338), Expect = 4e-31
Identities = 93/266 (34%), Positives = 143/266 (52%), Gaps = 13/266 (4%)
Query: 11 IEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVK--KRDG 68
+ ED D TS I P D AEAV+ ++ ++ G F+ ++++ +G
Sbjct: 17 LAEDIGEADWTSLLIDP-DASAEAVLTVREPALLCGRPWFDETFQQVDPRITIEWLVGEG 75
Query: 69 EEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTR 128
E + G+ + + G AR +L ERTALN + +SG+ATET + + V+ + ++ TR
Sbjct: 76 ERMHEGQAVCRIAGLARGMLTAERTALNFIQLLSGVATETSLMTQIVE--GTSARILDTR 133
Query: 129 KSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLAL-VPLEEAIRRAKEFSMYKVVE 185
K+L LRL K A+ +GGGE HR L D ILIK+NH+A + +R + V+
Sbjct: 134 KTLPGLRLAQKYAVRVGGGENHRRGLYDGILIKENHIAAGGGIASTLRATEALGAGVPVQ 193
Query: 186 VEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIE 245
VEVE+L++ +A GA I+LDN + + E R+ ++EVSGG+T +
Sbjct: 194 VEVETLDELKEALAGGAAAILLDNFS----IEAMREAVRV-TAGRAELEVSGGVTEQTLR 248
Query: 246 EYAKLDVDVISLGYLTHSVKNFDVSL 271
A+ VD ISLG LT +V+ D SL
Sbjct: 249 TIAETGVDRISLGKLTKNVRAIDFSL 274
>gb|AAC99834.1| (U27709) nicotinate-nucleotide pyrophosphorylase [Pseudomonas
aeruginosa]
Length = 283
Score = 131 bits (326), Expect = 9e-30
Identities = 92/269 (34%), Positives = 143/269 (52%), Gaps = 14/269 (5%)
Query: 11 IEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFG--VSVSVKKRDG 68
+ ED GD+T++ I P+ EAEA +I ++ IAG +F V V+ + +
Sbjct: 21 LAEDVGGGDLTAQLIDPQ-REAEARVITREHATIAGRAWVDEVFRQVDPRVLVTWQVEES 79
Query: 69 EEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTR 128
+ V +++ +LKG ARA+L ER+ALN + +SG AT ++ + V VK+ TR
Sbjct: 80 QRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLV--AGTAVKLLDTR 137
Query: 129 KSLLRLI---DKKAIMIGGGEPHRFSLSDAILIKDNHLALVP-LEEAIRRAKEFSMYKVV 184
K+L R D HR L DA LIK+NH+A ++ AI A+ + K V
Sbjct: 138 KTLPRPAPGADSTRSPAAVATNHRIGLYDAFLIKENHIAACGGIDRAIAEARRIAPGKPV 197
Query: 185 EVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNI 244
EVEVE+L++ +A +AGADI+MLD + ++ + K+E SGGI + +
Sbjct: 198 EVEVENLDELRQALEAGADIVMLDELSLDDMRTAVAL-----TAGRAKLEASGGINESTL 252
Query: 245 EEYAKLDVDVISLGYLTHSVKNFDVSLEI 273
A+ VD IS+G LT V+ D+S+ +
Sbjct: 253 RNIAETGVDYISIGTLTKDVRAVDLSMRL 281
>sp|P74301|NADC_SYNY3 PROBABLE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]
(QUINOLINATE PHOSPHORIBOSYLTRANSFERASE
[DECARBOXYLATING]) (QAPRTASE) >gi|7449667|pir||S76136
hypothetical protein - Synechocystis sp. (strain PCC
6803) >gi|1653482|dbj|BAA18395.1| (D90914)
nicotinate-nucleotide pyrophosphorylase [Synechocystis
sp.]
Length = 295
Score = 122 bits (303), Expect = 5e-27
Identities = 87/276 (31%), Positives = 151/276 (54%), Gaps = 11/276 (3%)
Query: 6 YLLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVS--V 63
+L +++ ED GD +++ + + +A +AK++GVIAG+ A +F+ S+ V
Sbjct: 24 WLQQWLAEDIGRGDWSTQGLGLQH-RGQARWVAKENGVIAGLPMAARIFQLLDPSMEFQV 82
Query: 64 KKRDGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVK 123
+G+ V A V+ + GN ++L ER ALN++ +SGIAT TR+ V+ + + +
Sbjct: 83 LAGEGQAVTASTVVATMAGNLGSLLTGERVALNLVMGLSGIATMTRQYVQAI--ADYPTR 140
Query: 124 VAGTRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHL-ALVPLEEAIRRAKEFSM 180
TRK+ LR+++K A +GG HR L DA+++KDNH+ A + +A++ ++
Sbjct: 141 FVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDNHIQAAGSITKAVQTLRQNLP 200
Query: 181 YKV-VEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGI 239
Y + +EVE +LE+ +A +IIMLDNM + ++ +++ I+IE SG +
Sbjct: 201 YPLAIEVETSNLEEVQEAIATQVEIIMLDNMGTDTMATAVKLIRQ--ANPLIRIEASGNV 258
Query: 240 TPNNIEEYAKLDVDVISLGYLTHSVKNFDVSLEIKR 275
T N+ A VD IS D+S++I R
Sbjct: 259 TLANLTAIASTGVDFISSSAPITRSPWLDLSMQIVR 294
>sp|Q08384|MODD_RHOCA MOLYBDENUM TRANSPORT SYSTEM PROTEIN MODD >gi|310273|gb|AAA71908.1|
(L06254) part of molybdenum transport system
[Rhodobacter capsulatus]
Length = 259
Score = 111 bits (274), Expect = 1e-23
Identities = 74/242 (30%), Positives = 121/242 (49%), Gaps = 8/242 (3%)
Query: 7 LLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKR 66
L+ I ED P GD+T+ ++ E + A+ +A EEA + + G +
Sbjct: 9 LMALIREDVPAGDLTTRSLGLAAEAGELTMRARGAMTVACSEEAVRILQLLGAEAWIATA 68
Query: 67 DGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAG 126
G +V GE++L +G A+L + A N++ SG+A+ +V + VNP V VA
Sbjct: 69 SGRQVEGGEMLLFARGQVEALLAGWKVAQNLIEWASGLASSATAIVAAARAVNPAVTVAC 128
Query: 127 TRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLAL---VPLEEAIRRAKEFSMY 181
TRKS+ R + +A+ +GG HR LSD++L+ H A L I R +
Sbjct: 129 TRKSVPGTRALSLRAVTVGGATVHRTGLSDSVLLFAEHRAFGGADALAAQIARLRASCPE 188
Query: 182 KVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITP 241
+ V VEV + +A+ AA+AGA+++ L+ P+++ V+ LG + +GGIT
Sbjct: 189 RKVVVEVADVAEALAAAQAGAEVLQLEKFPPEQVAAVV---AGLGPDWRGHVAAAGGITA 245
Query: 242 NN 243
N
Sbjct: 246 AN 247
>pir||B36914 probable nicotinate-nucleotide pyrophosphorylase (carboxylating)
(EC 2.4.2.19) modD [similarity] - Rhodobacter capsulatus
Length = 258
Score = 111 bits (274), Expect = 1e-23
Identities = 74/242 (30%), Positives = 121/242 (49%), Gaps = 8/242 (3%)
Query: 7 LLKFIEEDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKR 66
L+ I ED P GD+T+ ++ E + A+ +A EEA + + G +
Sbjct: 9 LMALIREDVPAGDLTTRSLGLAAEAGELTMRARGAMTVACSEEAVRILQLLGAEAWIATA 68
Query: 67 DGEEVRAGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAG 126
G +V GE++L +G A+L + A N++ SG+A+ +V + VNP V VA
Sbjct: 69 SGRQVEGGEMLLFARGQVEALLAGWKVAQNLIEWASGLASSATAIVAAARAVNPAVTVAC 128
Query: 127 TRKSL--LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLAL---VPLEEAIRRAKEFSMY 181
TRKS+ R + +A+ +GG HR LSD++L+ H A L I R +
Sbjct: 129 TRKSVPGTRALSLRAVTVGGATVHRTGLSDSVLLFAEHRAFGGADALAAQIARLRASCPE 188
Query: 182 KVVEVEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITP 241
+ V VEV + +A+ AA+AGA+++ L+ P+++ V+ LG + +GGIT
Sbjct: 189 RKVVVEVADVAEALAAAQAGAEVLQLEKFPPEQVAAVV---AGLGPDWRGHVAAAGGITA 245
Query: 242 NN 243
N
Sbjct: 246 AN 247
>sp|Q57278|MODD_HAEIN MOLYBDENUM TRANSPORT SYSTEM PROTEIN MODD HOMOLOG
>gi|1075030|pir||H64125 modD protein homolog -
Haemophilus influenzae (strain Rd KW20)
>gi|1574314|gb|AAC23121.1| (U32825) molybdenum transport
system protein (modD) [Haemophilus influenzae Rd]
Length = 281
Score = 103 bits (254), Expect = 3e-21
Identities = 64/246 (26%), Positives = 127/246 (51%), Gaps = 8/246 (3%)
Query: 13 EDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGEEVR 72
ED GD+T+ A+ E++ A+ + K GV+AGV A+ L + + + ++GE V
Sbjct: 15 EDIYRGDLTTHALSIENIPAKILFKRKNAGVVAGVSVAEKLLKKLDIQPHLYVKEGEWVE 74
Query: 73 AGEVILELKGNARAILLVERTALNIMGRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL- 131
+G +++ +G + + + ++ G+A T +++ K VNP VA TRKS+
Sbjct: 75 SGALLISAEGMSEQLHQAWKVVQLVLEWSCGVAQYTAEMIANAKSVNPTAVVACTRKSIP 134
Query: 132 -LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALV----PLEEAIRRAKEFSMYKVVEV 186
R + A++ GG HR +S+ +L+ NH L+ + + R ++ + + +
Sbjct: 135 NTRKLATNAVLAAGGHIHRQGVSETLLVFTNHRNLLSDPNDWTKIVDRLRQEAPENKITL 194
Query: 187 EVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIEE 246
E ++ + A DII LD +++ + ++ L+ +++I + V+GG+ NN+ +
Sbjct: 195 EADNYAQFEQMYMAEPDIIQLDKWLLEDVKKALDLLQ--SKQKDILLSVAGGVNKNNVSD 252
Query: 247 YAKLDV 252
YAKL +
Sbjct: 253 YAKLGI 258
>sp|P94777|MODD_ECOLI MOLYBDENUM TRANSPORT SYSTEM PROTEIN MODD HOMOLOG
>gi|1816657|gb|AAB42092.1| (U85771) molybdenum transport
protein homolog [Escherichia coli]
Length = 285
Score = 73.7 bits (178), Expect = 2e-12
Identities = 57/242 (23%), Positives = 109/242 (44%), Gaps = 9/242 (3%)
Query: 13 EDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGEEVR 72
ED GD+T+ A+ +Q G ++G+ A + G+++ DG +
Sbjct: 15 EDIQGGDLTTRALNIGHQHGYIEFFLRQGGCVSGISVACKMLTTLGLTIDDAVSDGSQAN 74
Query: 73 AGEVILELKGNARAILLVERTALNIM-GRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL 131
AG+ ++ +GNA A+ + N++ + + K V A TRK++
Sbjct: 75 AGQRLIRAQGNAAALHQGWKAVQNVLEWSLRLFLIISLKCWRYFVNVTLMAIFACTRKAI 134
Query: 132 --LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEE----AIRRAKEFSMYKVVE 185
RL+ +AI+ GG HR ++ IL+ NH + + AI + + + K +
Sbjct: 135 PGTRLLPSQAILAAGGLIHRAGCAETILLFANHRHFLHDNQDWSGAINQLRRHAPEKKIV 194
Query: 186 VEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIE 245
VE ++ ++AI A +A D++ LD PQ+ + + L + + ++GGI ++
Sbjct: 195 VEADAPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAP--SLAPHCTLALTGGINLTTLK 252
Query: 246 EY 247
Y
Sbjct: 253 NY 254
>gb|AAC61710.1| (AF081283) molybdenum transport protein [Escherichia coli]
Length = 285
Score = 73.4 bits (177), Expect = 3e-12
Identities = 57/242 (23%), Positives = 109/242 (44%), Gaps = 9/242 (3%)
Query: 13 EDAPYGDVTSEAIIPEDMEAEAVIIAKQDGVIAGVEEAKVLFEHFGVSVSVKKRDGEEVR 72
ED GD+T+ A+ +Q G ++G+ A + G+++ DG +
Sbjct: 15 EDIQGGDLTTRALNIGHQHGYIEFFLRQGGCVSGISVACKMLTTLGLTIDDAVSDGSQAN 74
Query: 73 AGEVILELKGNARAILLVERTALNIM-GRMSGIATETRKLVEKVKRVNPNVKVAGTRKSL 131
AG+ ++ +GNA A+ + N++ + + K V A TRK++
Sbjct: 75 AGQRLIRAQGNAAALHQGWKAVQNVLEWSLRLFLIISLKCWRYFVNVTLMAIFACTRKAI 134
Query: 132 --LRLIDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEE----AIRRAKEFSMYKVVE 185
RL+ +AI+ GG HR ++ IL+ NH + + AI + + + K +
Sbjct: 135 PGTRLLASQAILAAGGLIHRAGCAETILLFANHRHFLHDNQDWSGAINQLRRHAPEKKIV 194
Query: 186 VEVESLEDAIKAAKAGADIIMLDNMKPQEIVRVIEELKRLGLRENIKIEVSGGITPNNIE 245
VE ++ ++AI A +A D++ LD PQ+ + + L + + ++GGI ++
Sbjct: 195 VEADTPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAP--SLAPHCTLALTGGINLTTLK 252
Query: 246 EY 247
Y
Sbjct: 253 NY 254
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.316 0.136 0.358
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90504313
Number of Sequences: 2977
Number of extensions: 3501665
Number of successful extensions: 12475
Number of sequences better than 1.0e-10: 45
Number of HSP's better than 0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 12321
Number of HSP's gapped (non-prelim): 48
length of query: 279
length of database: 189,106,746
effective HSP length: 62
effective length of query: 217
effective length of database: 152,000,552
effective search space: 32984119784
effective search space used: 32984119784
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 164 (68.3 bits)