BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2373 (CDC21) DE:CELL DIVISION CONTROL PROTEIN.
(1112 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||D75056 cell division control protein. PAB2373 - Pyrococcus ... 2189 0.0
pir||E71104 probable cell division control protein - Pyrococcus ... 1724 0.0
gb|AAG20316.1| (AE005105) MCM / cell division control protein 21... 338 2e-91
gi|11498128 cell division control protein 21 (cdc21) [Archaeoglo... 312 1e-83
pir||D69103 DNA helicase (EC 3.6.1.-) MTH1770 [validated] - Meth... 298 2e-79
gb|AAK41071.1| Minichromosome maintenance protein MCM [Sulfolobu... 291 3e-77
emb|CAB57529.1| (Y18930) minichromosome maintenance (MCM) protei... 291 3e-77
emb|CAC11929.1| (AL445065) DNA replication licensing factor MCM ... 271 3e-71
pir||B72775 probable DNA replication licensing factor mcm APE018... 263 6e-69
gi|6325276 Involved in initiation of DNA replication; Cdc54p [Sa... 241 3e-62
gb|AAD22296.1|AC007047_5 (AC007047) putative CDC21 protein [Arab... 237 4e-61
gb|AAC26671.1| (AC004483) putative DNA replication licensing fac... 217 5e-55
gb|AAF59242.1| (AE003841) dpa gene product [Drosophila melanogas... 217 5e-55
gb|AAA91232.1| (U46131) DNA replication initiator protein [Xenop... 217 5e-55
sp|Q26454|MCM4_DROME DNA REPLICATION LICENSING FACTOR MCM4 (DISC... 217 5e-55
pir||T47223 replication licensing factor MCM4 [validated] - Afri... 216 9e-55
sp|P33991|MCM4_HUMAN DNA REPLICATION LICENSING FACTOR MCM4 (CDC2... 216 9e-55
emb|CAA52801.1| (X74794) P1 Cdc21 protein [Homo sapiens] >gi|109... 216 9e-55
gi|6678828 mini chromosome maintenance deficient 4 homolog (S. c... 216 1e-54
sp|Q58884|YE89_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ1489 >gi|21... 215 2e-54
pir||T50408 cdc21 protein [imported] - fission yeast (Schizosac... 213 6e-54
sp|P29458|CC21_SCHPO CDC21 PROTEIN >gi|4165293|emb|CAA41628.1| (... 213 6e-54
sp|P30664|MCM4_XENLA DNA REPLICATION LICENSING FACTOR MCM4 (CDC2... 213 6e-54
pir||S26640 replication licensing factor MCM4 - fission yeast (... 213 6e-54
pir||T38702 hypothetical protein SPAC3F10.01 - fission yeast (Sc... 212 1e-53
sp|P41389|NDA4_SCHPO CELL DIVISION CONTROL PROTEIN NDA4 212 2e-53
pir||A48723 replication licensing factor MCM5 - fission yeast (... 211 3e-53
sp|Q57809|Y363_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ0363 >gi|21... 209 2e-52
sp|Q58371|Y961_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ0961 >gi|21... 208 3e-52
emb|CAB55276.1| (AL035461) dJ967N21.5 (novel MCM2/3/5 family mem... 207 6e-52
dbj|BAA09949.1| (D63920) xCDC46 [Xenopus laevis] 205 2e-51
sp|P55862|MCM5_XENLA DNA REPLICATION LICENSING FACTOR MCM5 (CDC4... 205 2e-51
emb|CAA73947.1| (Y13624) minichromosome maintenance like protein... 199 1e-49
gi|6321237 component of MCM initiator complex involved in DNA re... 199 1e-49
gi|6678830 mini chromosome maintenance deficient 5 (S. cerevisia... 199 1e-49
gb|AAD32857.1|AF124743_1 (AF124743) DNA replication factor MCM7 ... 198 4e-49
gb|AAF54557.1| (AE003688) Mcm5 gene product [Drosophila melanoga... 197 5e-49
gb|AAC47652.1| (U83493) MCM5 homolog [Drosophila melanogaster] 197 7e-49
gi|11418031 minichromosome maintenance deficient (S. cerevisiae)... 196 9e-49
sp|P33992|MCM5_HUMAN DNA REPLICATION LICENSING FACTOR MCM5 (CDC4... 196 1e-48
gb|AAF18476.1|AF211951_1 (AF211951) minichromosome maintenance 5... 195 2e-48
gi|6323304 MCM initiator complex protein; Cdc46p [Saccharomyces ... 195 3e-48
dbj|BAA34733.1| (AB010109) MCM7 [Drosophila melanogaster] 194 6e-48
pir||T50339 mis5 protein [imported] - fission yeast (Schizosacch... 194 6e-48
gi|6981192 minichromosome maintenance deficient (S. cerevisiae) ... 193 1e-47
emb|CAB05110.1| (Z82244) bK286B10.3 (minichromosome maintenance ... 193 1e-47
dbj|BAB11083.1| (AB010698) MCM3 homolog [Arabidopsis thaliana] 192 2e-47
emb|CAA03887.1| (AJ000058) MCM3 homolog [Arabidopsis thaliana] 192 2e-47
emb|CAA10166.1| (AJ012750) MCM3 protein [Pisum sativum] 191 3e-47
sp|P49731|MIS5_SCHPO MIS5 PROTEIN >gi|11274808|pir||T43423 proba... 191 3e-47
pir||I38080 replication licensing factor MCM5 - human 191 4e-47
pir||T03920 replication licensing factor MCM7 - Caenorhabditis e... 191 4e-47
gb|AAF17244.1|AF203971_1 (AF203971) minichromosome maintenance p... 190 5e-47
pir||T39991 minichromosome maintenance protein mcm7p [imported] ... 190 7e-47
sp|P43299|PROL_ARATH PROLIFERA PROTEIN >gi|675491|gb|AAC37429.1|... 190 9e-47
pir||T01507 replication licensing factor MCM7 - Arabidopsis thal... 190 9e-47
sp|P49735|MCM2_DROME DNA REPLICATION LICENSING FACTOR MCM2 >gi|8... 189 1e-46
gb|AAB94861.1| (AF014813) DNA replication licensing factor [Aspe... 189 1e-46
sp|P38132|CC47_YEAST CELL DIVISION CONTROL PROTEIN 47 >gi|608169... 189 2e-46
sp|Q91876|MCM7_XENLA DNA REPLICATION LICENSING FACTOR MCM7 (CDC4... 188 3e-46
pir||T47221 replication licensing factor MCM7 [validated] - Afri... 188 3e-46
pir||S62607 minichromosome maintenance protein, 85K - human (fra... 187 4e-46
gi|10242373 mini chromosome maintenance deficient 7 (S. cerevisi... 187 4e-46
sp|P33993|MCM7_HUMAN DNA REPLICATION LICENSING FACTOR MCM7 (CDC4... 187 4e-46
gb|AAC60228.1| (U66710) CDC47-2p [Xenopus laevis] 187 4e-46
gb|AAF23296.1|AC016661_21 (AC016661) putative minichromosome mai... 187 4e-46
gb|AAG01994.1| (AY007130) similar to Homo sapiens mRNA for hMCM2... 187 4e-46
dbj|BAA05839.1| (D28480) hMCM2 [Homo sapiens] >gi|1094423|prf||2... 187 4e-46
pir||T47222 replication licensing factor MCM6 [validated] - Afri... 187 6e-46
gb|AAC41267.1| (AF031139) zygotic DNA replication factor MCM6b [... 187 6e-46
gi|6678832 mini chromosome maintenance deficient 6 (S. cerevisia... 186 1e-45
gi|7427519 minichromosome maintenance deficient (mis5, S. pombe)... 186 1e-45
gb|AAD32858.1|AF124744_1 (AF124744) DNA replication factor MCM6 ... 186 1e-45
gi|11429381 minichromosome maintenance deficient (mis5, S. pombe... 186 1e-45
sp|P40377|CC19_SCHPO CELL DIVISION CONTROL PROTEIN 19 >gi|542209... 185 2e-45
sp|Q62724|MCM6_RAT DNA REPLICATION LICENSING FACTOR MCM6 (INTEST... 185 2e-45
gb|AAD48445.1|AF164200_1 (AF164200) putative DNA replication pro... 185 2e-45
pir||T26498 hypothetical protein Y17G7B.5 - Caenorhabditis elega... 185 2e-45
dbj|BAA34732.1| (AB010108) MCM6 [Drosophila melanogaster] 185 2e-45
gb|AAC50766.1| (U46838) p105MCM [Homo sapiens] 184 4e-45
emb|CAB55370.1| (AL117260) DNA replication licensing factor (CDC... 183 1e-44
sp|P34647|MCM6_CAEEL DNA REPLICATION LICENSING FACTOR MCM6 HOMOL... 182 3e-44
pir||S40933 probable replication licensing factor MCM6 - Caenorh... 182 3e-44
sp|P30666|MCM3_SCHPO MINICHROMOSOME MAINTENANCE PROTEIN 3 HOMOLO... 181 4e-44
gb|AAD48086.1|AF073330_1 (AF073330) replication origin activator... 180 7e-44
gb|AAD48087.1|AF073331_1 (AF073331) replication origin activator... 180 7e-44
pir||T47225 replication licensing factor MCM2 [validated] - Afri... 180 7e-44
dbj|BAA04642.1| (D21063) KIAA0030 [Homo sapiens] 180 1e-43
sp|P49736|MCM2_HUMAN DNA REPLICATION LICENSING FACTOR MCM2 (NUCL... 180 1e-43
pir||I51589 P1 homolog - African clawed frog (fragment) >gi|8680... 179 1e-43
sp|P55861|MCM2_XENLA DNA REPLICATION LICENSING FACTOR MCM2 (X.MC... 178 2e-43
sp|Q43704|MCM3_MAIZE DNA REPLICATION LICENSING FACTOR MCM3 HOMOL... 177 5e-43
sp|Q21902|MCM5_CAEEL DNA REPLICATION LICENSING FACTOR MCM5 HOMOL... 177 5e-43
sp|P49739|MCM3_XENLA DNA REPLICATION LICENSING FACTOR MCM3 (X.MC... 177 5e-43
gi|6319679 MCM3 protein homolog (S. cerevisiae); Cdc47p [Sacchar... 177 5e-43
gb|AAC16250.1| (AF004105) BM28 homolog [Mus musculus] 177 5e-43
gi|6678826 mini chromosome maintenance deficient 2 (S. cerevisia... 177 5e-43
gi|6319448 Minichromosome maintenance protein, transcription fac... 176 1e-42
emb|CAA69609.1| (Y08301) MCM2-related protein [Arabidopsis thali... 176 1e-42
gb|AAF78275.1|AC020576_19 (AC020576) Contains similarity to a MC... 176 1e-42
emb|CAA37615.1| (X53539) MCM2 [Saccharomyces cerevisiae] 175 2e-42
pir||T19446 hypothetical protein C25D7.6 - Caenorhabditis elegan... 175 3e-42
emb|CAA72333.1| (Y11594) B24 protein [Triturus carnifex] 175 3e-42
pir||I51022 replication licensing factor MCM3 - eastern newt (fr... 175 3e-42
dbj|BAA07267.1| (D38073) hRlf beta subunit (p102 protein) [Homo ... 173 1e-41
gi|6631095 minichromosome maintenance deficient (S. cerevisiae) ... 173 1e-41
dbj|BAA34731.1| (AB010107) MCM3 [Drosophila melanogaster] 173 1e-41
sp|P25205|MCM3_HUMAN DNA REPLICATION LICENSING FACTOR MCM3 (DNA ... 172 2e-41
gb|AAG37990.1|AF095948_1 (AF095948) DNA replication licensing fa... 171 3e-41
gb|AAD32859.1|AF124745_1 (AF124745) DNA replication factor MCM3 ... 171 5e-41
pir||S17100 P1.m protein - mouse (fragment) >gi|53551|emb|CAA440... 169 1e-40
sp|P25206|MCM3_MOUSE DNA REPLICATION LICENSING FACTOR MCM3 (DNA ... 169 1e-40
pir||S22804 replication licensing factor MCM3 - mouse (fragment) 169 1e-40
gi|11433475 minichromosome maintenance deficient (S. cerevisiae)... 169 1e-40
sp|Q24849|MCM3_ENTHI DNA REPLICATION LICENSING FACTOR MCM3 >gi|1... 161 4e-38
gi|4758706 minichromosome maintenance deficient (S. cerevisiae) ... 161 5e-38
gb|AAC52018.1| (U63630) MCM4 [Homo sapiens] 159 2e-37
pir||S43199 cell division control protein CDC46 - human (fragment) 151 4e-35
pir||T41090 cdc21 protein - fission yeast (Schizosaccharomyces p... 145 3e-33
gi|6320803 component of DNA replication initiator complex; Mcm3p... 143 1e-32
gb|AAG37988.1|AF083323_1 (AF083323) DNA replication licensing fa... 141 3e-32
emb|CAB59865.1| (AL132763) possible DNA replication licensing fa... 139 1e-31
emb|CAB89596.1| (AL354513) possible putative minichromosome main... 124 6e-27
gi|10954504 M. jannaschii predicted coding region MJECL13 [Metha... 101 4e-20
gb|AAD19787.1| (AC006528) putative DNA replication licensing fac... 95 4e-18
pir||H71450 probable DNA repair protein - Pyrococcus horikoshii ... 89 2e-16
sp|Q58446|RPA2_METJA DNA-DIRECTED RNA POLYMERASE SUBUNIT A" >gi|... 89 2e-16
gb|AAC36509.1| (U89402) cdc21 [Mus musculus] 76 3e-12
>pir||D75056 cell division control protein. PAB2373 - Pyrococcus abyssi (strain
Orsay) >gi|5458858|emb|CAB50345.1| (AJ248287) CELL
DIVISION CONTROL PROTEIN. [Pyrococcus abyssi]
Length = 1112
Score = 2189 bits (5610), Expect = 0.0
Identities = 1112/1112 (100%), Positives = 1112/1112 (100%)
Query: 1 MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV 60
MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV
Sbjct: 1 MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV 60
Query: 61 LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEG
Sbjct: 61 LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFV 180
VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFV
Sbjct: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFV 180
Query: 181 NFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTF 240
NFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTF
Sbjct: 181 NFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTF 240
Query: 241 KKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGI 300
KKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGI
Sbjct: 241 KKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGI 300
Query: 301 ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAKCVDYETEVVLGNGERKKIGEIVERAI 360
ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAKCVDYETEVVLGNGERKKIGEIVERAI
Sbjct: 301 ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAKCVDYETEVVLGNGERKKIGEIVERAI 360
Query: 361 EEAEKNGKLGRVDDGFYAPIDIEVYSLDLETLKVRKARANIAWKRTAPKKMMLVKTRGGK 420
EEAEKNGKLGRVDDGFYAPIDIEVYSLDLETLKVRKARANIAWKRTAPKKMMLVKTRGGK
Sbjct: 361 EEAEKNGKLGRVDDGFYAPIDIEVYSLDLETLKVRKARANIAWKRTAPKKMMLVKTRGGK 420
Query: 421 RIRVTPTHPFFVLEEGKVAMRKARDLEEGNKIATIEGLSVSWDEVAEILEYEPKDPWVYD 480
RIRVTPTHPFFVLEEGKVAMRKARDLEEGNKIATIEGLSVSWDEVAEILEYEPKDPWVYD
Sbjct: 421 RIRVTPTHPFFVLEEGKVAMRKARDLEEGNKIATIEGLSVSWDEVAEILEYEPKDPWVYD 480
Query: 481 LQVPGYHNFLANGIFVHNSQLLRYIANLAPRAIYTSGKSSSAAGLCVAPETLIITENGTK 540
LQVPGYHNFLANGIFVHNSQLLRYIANLAPRAIYTSGKSSSAAGLCVAPETLIITENGTK
Sbjct: 481 LQVPGYHNFLANGIFVHNSQLLRYIANLAPRAIYTSGKSSSAAGLCVAPETLIITENGTK 540
Query: 541 EIGEVVERWMKELGEIEYDDGISYSPAFEKVASLNGGKVKMLPVRRVWKLRSPGKMIKIR 600
EIGEVVERWMKELGEIEYDDGISYSPAFEKVASLNGGKVKMLPVRRVWKLRSPGKMIKIR
Sbjct: 541 EIGEVVERWMKELGEIEYDDGISYSPAFEKVASLNGGKVKMLPVRRVWKLRSPGKMIKIR 600
Query: 601 SESGKQITVTPETKLLTIIDGSLEWVEARKLKKGNYVAVVNKERSIVPIGDFLAKLLKFY 660
SESGKQITVTPETKLLTIIDGSLEWVEARKLKKGNYVAVVNKERSIVPIGDFLAKLLKFY
Sbjct: 601 SESGKQITVTPETKLLTIIDGSLEWVEARKLKKGNYVAVVNKERSIVPIGDFLAKLLKFY 660
Query: 661 GVELNLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLVEMLSSME 720
GVELNLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLVEMLSSME
Sbjct: 661 GVELNLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLVEMLSSME 720
Query: 721 GELKEEVMLLLSDVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEG 780
GELKEEVMLLLSDVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEG
Sbjct: 721 GELKEEVMLLLSDVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEG 780
Query: 781 SHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEA 840
SHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEA
Sbjct: 781 SHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEA 840
Query: 841 LEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVL 900
LEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVL
Sbjct: 841 LEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVL 900
Query: 901 VDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIE 960
VDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIE
Sbjct: 901 VDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIE 960
Query: 961 KYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME 1020
KYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME
Sbjct: 961 KYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME 1020
Query: 1021 YTLRQIAVDETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKK 1080
YTLRQIAVDETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKK
Sbjct: 1021 YTLRQIAVDETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKK 1080
Query: 1081 FGIEKQEAREILEKLLEQGQIYMPENGYYRTV 1112
FGIEKQEAREILEKLLEQGQIYMPENGYYRTV
Sbjct: 1081 FGIEKQEAREILEKLLEQGQIYMPENGYYRTV 1112
>pir||E71104 probable cell division control protein - Pyrococcus horikoshii
>gi|3257012|dbj|BAA29695.1| (AP000003) 1108aa long
hypothetical cell division control protein [Pyrococcus
horikoshii]
Length = 1108
Score = 1724 bits (4416), Expect = 0.0
Identities = 856/1118 (76%), Positives = 987/1118 (87%), Gaps = 16/1118 (1%)
Query: 1 MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV 60
M+REEIIERFL+F REYAEEGEEPLY+GKIKDLL ITPKRSI INWMHLNS+DPELAEEV
Sbjct: 1 MEREEIIERFLKFFREYAEEGEEPLYMGKIKDLLTITPKRSIVINWMHLNSYDPELAEEV 60
Query: 61 LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
+ENPEECILAAEDAIQIILKED +REDVP+IHARF+NLPKTLMVKE+GAEHINKLIQVEG
Sbjct: 61 IENPEECILAAEDAIQIILKEDFLREDVPKIHARFHNLPKTLMVKEVGAEHINKLIQVEG 120
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFV 180
VVTRVTEIKPFVS AVFVCKDCGHEMVV QKPYEGFVAVKKCE+CGSKNVQLDVEKSKFV
Sbjct: 121 VVTRVTEIKPFVSVAVFVCKDCGHEMVVPQKPYEGFVAVKKCEQCGSKNVQLDVEKSKFV 180
Query: 181 NFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTF 240
NFQMFRIQDRPE+L+GGQMPRFIDGILLDDIVDTAMPGDRV+VVGILRV+QEKREKVPTF
Sbjct: 181 NFQMFRIQDRPESLRGGQMPRFIDGILLDDIVDTAMPGDRVIVVGILRVIQEKREKVPTF 240
Query: 241 KKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGI 300
KKVIEVN+IEP+SKE+EELEI+PE+EQKIRELAKRKDIV AIVDSIAPAIYGY+EVKKGI
Sbjct: 241 KKVIEVNHIEPISKELEELEISPEDEQKIRELAKRKDIVSAIVDSIAPAIYGYKEVKKGI 300
Query: 301 ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAKCVDYETEVVLGNGERKKIGEIVERAI 360
ALALFGGV RTLPDGTRLRGDIHVLLVGDPGVAKCVDY+TEV+LG+G ++KIGEIVE AI
Sbjct: 301 ALALFGGVSRTLPDGTRLRGDIHVLLVGDPGVAKCVDYDTEVLLGDGRKRKIGEIVEEAI 360
Query: 361 EEAEKNGKLGRVDDGFYAPIDIEVYSLDLETLKVRKARANIAWKRTAPKKMMLVKTRGGK 420
++AEK GKLGRVDDGFYAPI++E+Y+LD+ TLKVRK +A+IAWKRT P+KM+ ++T+ G+
Sbjct: 361 KKAEKEGKLGRVDDGFYAPINLELYALDVRTLKVRKVKADIAWKRTTPEKMLRIRTKRGR 420
Query: 421 RIRVTPTHPFFVLEEGKVAMRKARDLEEGNKIAT----IEGLSVSWDEVAEILEYEPKDP 476
IRVTPTHPFF LEEG++ +KA +L+ G KIAT + WDEV EI EY+P +
Sbjct: 421 EIRVTPTHPFFTLEEGRIKTKKAYELKVGEKIATPREEAPEAEIFWDEVVEIEEYKPNNS 480
Query: 477 WVYDLQVPGYHNFLANGIFVHNSQLLRYIANLAPRAIYTSGKSSSAAGLCVAPETLIITE 536
WVYDLQVP +HNF+ANGIFVHNSQLLRY+ANLAPRAIYTSGKSSSAAGLCVAP+TLI T+
Sbjct: 481 WVYDLQVPEHHNFIANGIFVHNSQLLRYVANLAPRAIYTSGKSSSAAGLCVAPDTLINTD 540
Query: 537 NGTKEIGEVVERWMKELGEIEYDDGISYSPAFEKVASLNGGKVKMLPVRRVWKLRSPGKM 596
NG EIG+ VE WMKE+GEI ++GISY+P F KV + GK+ P+RRVWKLR+P K+
Sbjct: 541 NGRVEIGKFVEEWMKEVGEIS-EEGISYAPCFRKVETFKDGKIVESPIRRVWKLRAPKKL 599
Query: 597 IKIRSESGKQITVTPETKLLTIIDGSLEWVEARKLKKGNYVAVVNKERSIVP-IGDFLAK 655
++I++E+G+ I +T ETKLLTI DG L WVEA ++K G YV V E+ ++P G +
Sbjct: 600 VRIKTENGRSIALTRETKLLTINDGELSWVEAGEVKVGTYVGTVKSEKDVIPGAGKTIRD 659
Query: 656 LLKFYGVELNLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLVEM 715
+ K Y +E+ + + + R++ RK +E L+ + ++ + I+IP + Y +L+
Sbjct: 660 VSKLYNMEMEVKDYLTREEVRKAIEKLE-EIMNPMNIKIPGV--------QESYEELLRK 710
Query: 716 LSSMEGE-LKEEVMLLLSDVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVY 774
L + E ++ E ++LLSDV D HE+ +E++++I +I+ S+ WE++ EV EV +VY
Sbjct: 711 LETTNDERVRNETLILLSDVSDAHELAKEKIEKIKEIVNSEVHWEKVTEVGEVDGVEYVY 770
Query: 775 DLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDR 834
DLTVEGSH+F+ANGF+VHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKM+D+DR
Sbjct: 771 DLTVEGSHNFVANGFIVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMSDRDR 830
Query: 835 SVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRF 894
SVIHEALEQQTISLSKAGITATLNARTTVIAAANPK GRFNRMKR+SEQI+LPPTL+SRF
Sbjct: 831 SVIHEALEQQTISLSKAGITATLNARTTVIAAANPKHGRFNRMKRVSEQIDLPPTLLSRF 890
Query: 895 DLIFVLVDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEE 954
DLIFVL+DEPDEK+DSEIARHIL+VRRGESEVVTPKIPH+LLRKYIAYARKN+HPVISEE
Sbjct: 891 DLIFVLMDEPDEKVDSEIARHILKVRRGESEVVTPKIPHELLRKYIAYARKNIHPVISEE 950
Query: 955 AMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDARE 1014
AMEEIEKYYVKMR+S KKSS +EIKPIPITARQLEALIRLSEAHARMRLSPIVTREDARE
Sbjct: 951 AMEEIEKYYVKMRRSAKKSSGDEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDARE 1010
Query: 1015 AIKLMEYTLRQIAVDETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDI 1074
AIKLMEYTL+QIAVDE GQ+DVTILEVGQSARKLSKVERILDI+EKLE TSEKGAKIDDI
Sbjct: 1011 AIKLMEYTLKQIAVDEAGQLDVTILEVGQSARKLSKVERILDIVEKLERTSEKGAKIDDI 1070
Query: 1075 LEEAKKFGIEKQEAREILEKLLEQGQIYMPENGYYRTV 1112
LEEA KFGIEK EAREILEKLLE+GQIYMPENGYY+TV
Sbjct: 1071 LEEAAKFGIEKSEAREILEKLLEKGQIYMPENGYYKTV 1108
>gb|AAG20316.1| (AE005105) MCM / cell division control protein 21; Mcm
[Halobacterium sp. NRC-1]
Length = 831
Score = 338 bits (858), Expect = 2e-91
Identities = 194/549 (35%), Positives = 309/549 (55%), Gaps = 49/549 (8%)
Query: 53 DPELAEEVLENPEECILAAEDAIQII-LKEDIMREDVPRIHARFYNLPKTLMVKEIGAEH 111
DP+LA++ + +P++ AAE+A+++ L D+ + + H R + L + ++ I AEH
Sbjct: 2 DPDLADDYISHPDQLQEAAEEALRVYDLPVDV---SLGQAHVRVHGLAEHTDIRAIRAEH 58
Query: 112 INKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-V 170
+N ++ ++G+V + T++ P + AVFVC+ CG + V Q GF +CE C +
Sbjct: 59 LNTMVSIQGMVRKATDVMPKIQRAVFVCQRCGTDTEVPQGD-AGFQEPYQCESCERQGPF 117
Query: 171 QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV 230
+LD ++S+FV+ Q RIQ+ PE L GG+ P+ ID + DD PGD V V G+LR+
Sbjct: 118 KLDPDRSEFVDSQKLRIQESPEGLGGGETPQSIDVHVEDDATGNVTPGDHVTVTGVLRLD 177
Query: 231 Q-EKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPA 289
Q E+ P F+ +E + + E +EL I+ ++++I L+ ++I + +VDS+APA
Sbjct: 178 QSEEATDSPVFEHYMEGSSVVIEDAEFDELNISEADKEEIVALSDHEEIHEEMVDSMAPA 237
Query: 290 IYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAKCVDYETEVVLGNGER 349
IYG+RE K + L LF GV + LPD +R+RGD+H+LL+GDPG KCV +T V L +G
Sbjct: 238 IYGHREAKLAMMLQLFSGVTKHLPDKSRIRGDLHMLLIGDPGTGKCVRGDTTVALADGSE 297
Query: 350 KKIGEIVERAIEEAEKNGKLGRVDDGFYAPIDIEVYSLDLETLKVRKARANIAWKRTAPK 409
++I ++VE +++ VDDG + +D+ V SL + V++ RA WKR AP+
Sbjct: 298 REIRDLVEANLDDPRP------VDDGVWDGVDVAVPSLAADGRLVQR-RATKVWKREAPE 350
Query: 410 KMMLVKTRGGKRIRVTPTHPFFVLEEGKVAMRKARDLEEGNKIATI-------------- 455
M V+T G R+ VTP+HP FV + DLE G +
Sbjct: 351 TMYRVRTAAGHRLTVTPSHPLFVAGSHGPDAVRTEDLEVGQLVGVAPDGDGSGQVAPDGG 410
Query: 456 -----------EGLSVSWDEVAEILEYEPKDPWVYDLQVPGYHNFLANGIFVHNSQLLRY 504
+ +V+W + I E EP + WVYDL+V G H++L +G+ HNSQ++ Y
Sbjct: 411 VIRDAQPAPVGDAETVAWSAIESITEVEPDEEWVYDLEVEGTHSYLTDGVVSHNSQMISY 470
Query: 505 IANLAPRAIYTSGKSSSAAGLCVAPETLIITENGTKEIGEVVERWMKELGEIEY-DDGIS 563
+ N+APR++YTSGK SSAAGL A + G+ ++W E G + D+G++
Sbjct: 471 VQNIAPRSVYTSGKGSSAAGLTAAAV--------RDDFGD-GQQWSLEAGALVLADNGVA 521
Query: 564 YSPAFEKVA 572
+K+A
Sbjct: 522 AVDELDKMA 530
Score = 305 bits (774), Expect = 1e-81
Identities = 173/409 (42%), Positives = 248/409 (60%), Gaps = 57/409 (13%)
Query: 757 SWERIAEVEEVVRDGH-VYDLTVEGSHSFIANGFVVHN---------------------- 793
+W I + EV D VYDL VEG+HS++ +G V HN
Sbjct: 427 AWSAIESITEVEPDEEWVYDLEVEGTHSYLTDGVVSHNSQMISYVQNIAPRSVYTSGKGS 486
Query: 794 -----TAAVVRDEFTGG--WVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTI 846
TAA VRD+F G W LEAGALVLAD G A +DELDKM D DRS +HEALEQQ I
Sbjct: 487 SAAGLTAAAVRDDFGDGQQWSLEAGALVLADNGVAAVDELDKMADDDRSAMHEALEQQKI 546
Query: 847 SLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDE 906
S+SKAGI ATL AR +++ AANPK GRF++ + I EQI+L P L+SRFDLIF + D+PD
Sbjct: 547 SVSKAGINATLKARCSLLGAANPKYGRFDQYEPIGEQIDLEPALISRFDLIFTVTDQPDP 606
Query: 907 KIDSEIARHILRVR----------------------RGESEVVTPKIPHDLLRKYIAYAR 944
+ D+ +A HIL+ ++E V P I LLRKYIAYAR
Sbjct: 607 EEDAALADHILQTNYAGELNTQNEELANANYSEAEIESQTEDVAPAIEPGLLRKYIAYAR 666
Query: 945 KNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLS 1004
+ P ++ +A + IE++YV +R K ++E+ P+P+TARQLEA++RL+EA AR+RLS
Sbjct: 667 RTCFPTMTPDARQAIEEFYVDLR---SKGADED-APVPVTARQLEAIVRLAEASARLRLS 722
Query: 1005 PIVTREDAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKLEG 1063
V + DA I +++ L+ I VD ETG+ D ++E GQS + +V+ I +I ++E
Sbjct: 723 DSVEKSDADRVIGIVQSCLQDIGVDPETGEFDADVVETGQSKTQRDRVKNIKALIGEIEE 782
Query: 1064 TSEKGAKIDDILEEAKKFGIEKQEAREILEKLLEQGQIYMPENGYYRTV 1112
+ GA ++++L+ A++ G++ +A +EKL E+G++Y P + R++
Sbjct: 783 EFDDGAPVEEVLDRAEEIGMDAGKAEHEIEKLKERGELYQPNTDHLRSI 831
>gi|11498128 cell division control protein 21 (cdc21) [Archaeoglobus fulgidus]
>gi|7428562|pir||E69314 replication licensing factor
MCM-type homolog AF0517 - Archaeoglobus fulgidus
>gi|2650102|gb|AAB90715.1| (AE001068) cell division
control protein 21 (cdc21) [Archaeoglobus fulgidus]
Length = 586
Score = 312 bits (791), Expect = 1e-83
Identities = 169/341 (49%), Positives = 229/341 (66%), Gaps = 27/341 (7%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA VRDE G W LEAGALVLAD G AL+DE+DKM +D S +HEALEQQTIS++KAGI
Sbjct: 248 TATAVRDEVDGRWTLEAGALVLADKGIALVDEIDKMRKEDTSALHEALEQQTISVAKAGI 307
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A L AR ++ AANPK GRF + + EQI + PTL+SRFDLIFVL DEPDE+ D +
Sbjct: 308 NAILKARCALLGAANPKYGRFEKFTPVPEQIEMSPTLLSRFDLIFVLKDEPDEEKDKRLV 367
Query: 914 RHIL---------------------RVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVIS 952
HIL R SE + P+I DLLRKYIAYARK V+PV++
Sbjct: 368 EHILYSHQLGEMTEKAKNVAAEYDEEFIRQRSERIVPEIDPDLLRKYIAYARKTVYPVLT 427
Query: 953 EEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDA 1012
+EA E+I+++Y+ +R VK++S P+PITARQLE+++RL+EA AR+RLS V ED
Sbjct: 428 DEAKEKIKEFYLSLRSRVKENS-----PVPITARQLESIVRLAEASARVRLSDRVEPEDV 482
Query: 1013 REAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKI 1071
I++M +LR+IAVD ETG++D+ + G S + ++ + IIE+LE E+G
Sbjct: 483 DRVIEIMMRSLREIAVDPETGEMDIDLAYSGTSKTQRDRIMILKKIIEQLEEEHERGVPE 542
Query: 1072 DDILEEAKKFGIEKQEAREILEKLLEQGQIYMPENGYYRTV 1112
+ ILEEA+K GI++ +A+EIL KL G++Y P++G+Y+ V
Sbjct: 543 ELILEEAEKEGIDRTKAKEILSKLKLHGEVYTPKHGHYKLV 583
Score = 186 bits (467), Expect = 1e-45
Identities = 100/225 (44%), Positives = 140/225 (61%), Gaps = 15/225 (6%)
Query: 118 VEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQK------PYEGFVAVKKCEKCGSKNVQ 171
+EG+V +VTE++P + A F C +CG +V Q+ P+E C KC +K +
Sbjct: 3 IEGIVRKVTEVRPRIVEAAFACLNCGSITMVPQEDSQLRQPFE-------CSKCSTKKMI 55
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQ 231
+ S V+ Q +IQ+ PE L+GG+ P+ ID IL D+ + PGDRV++ GI+R
Sbjct: 56 FLPDSSISVDSQRVKIQEYPENLRGGEQPQTIDVILEGDLAGSVNPGDRVIINGIVRAKP 115
Query: 232 EK--REKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPA 289
+ K+ IE N +E + +E EE EIT ++ + I +LA DI + IV SIAP+
Sbjct: 116 RGLGQRKMTHMDLYIEGNSVEVLQQEYEEFEITEKDRELIMQLAASDDIYEKIVKSIAPS 175
Query: 290 IYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
IYG+ +VK IAL LFGGVP+ LPDGT +RGDIH+LLVGDPGVAK
Sbjct: 176 IYGHEDVKLAIALQLFGGVPKKLPDGTEIRGDIHILLVGDPGVAK 220
>pir||D69103 DNA helicase (EC 3.6.1.-) MTH1770 [validated] - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622900|gb|AAB86236.1| (AE000932) DNA replication
initiator (Cdc21/Cdc54) [Methanobacterium
thermoautotrophicum]
Length = 666
Score = 298 bits (756), Expect = 2e-79
Identities = 163/321 (50%), Positives = 227/321 (69%), Gaps = 9/321 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAA VRDEF GGW LEAGALVL D G +DELDKM ++DRS IHEALEQQTIS++KAGI
Sbjct: 353 TAAAVRDEF-GGWSLEAGALVLGDKGNVCVDELDKMREEDRSAIHEALEQQTISIAKAGI 411
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLN+R +V+AAANPK GRF+ K I+EQI+LP T++SRFDLIFV+ D+PDE+ D E+A
Sbjct: 412 MATLNSRCSVLAAANPKFGRFDSYKSIAEQIDLPSTILSRFDLIFVVEDKPDEEKDRELA 471
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKS 973
RHIL+ + + + +I +LLRKYIAYARKNV PV+++EAM+ +E +YV MR S
Sbjct: 472 RHILKTHK--EDHMPFEIDPELLRKYIAYARKNVRPVLTDEAMQVLEDFYVSMR----AS 525
Query: 974 SEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD-ETG 1032
+ +E P+PITARQLEAL+RLSEA A+++L V EDAR+AIKL + L+Q+ D ETG
Sbjct: 526 AADEDSPVPITARQLEALVRLSEASAKIKLKEHVEAEDARKAIKLSQACLKQVGYDPETG 585
Query: 1033 QIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEE-AKKFGIEKQEAREI 1091
+ID+ +E + K +L++I++ E A + ++ E ++ + +++ E+
Sbjct: 586 KIDIDKVEGRTPKSERDKFRLLLELIKEYEDDYGGRAPTNILITEMMDRYNVSEEKVEEL 645
Query: 1092 LEKLLEQGQIYMPENGYYRTV 1112
+ L ++G I+ P GY + V
Sbjct: 646 IRILKDKGAIFEPARGYLKIV 666
Score = 231 bits (584), Expect = 2e-59
Identities = 124/295 (42%), Positives = 190/295 (64%), Gaps = 7/295 (2%)
Query: 40 RSIAINWMHLNSFDPELAEEVLENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLP 99
RSI ++++ L FDP+LA+ ++E P++ I AA+ AI+ I D +R++V ++ RF +
Sbjct: 38 RSIEVDYLDLEMFDPDLADLLIEKPDDVIRAAQQAIRNI---DRLRKNVD-LNIRFSGIS 93
Query: 100 KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAV 159
+ ++E+ ++ I K + V+G+V + EI+P + AVF C+ C V Q
Sbjct: 94 NVIPLRELRSKFIGKFVAVDGIVRKTDEIRPRIVKAVFECRGCMRHHAVTQST-NMITEP 152
Query: 160 KKCEKCGSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGD 219
C +CG ++ +L ++S+F++ Q ++Q+ E L GG+ PR I +L DD+VDT PGD
Sbjct: 153 SLCSECGGRSFRLLQDESEFLDTQTLKLQEPLENLSGGEQPRQITVVLEDDLVDTLTPGD 212
Query: 220 RVVVVGILRVVQEKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIV 279
V V G LR V+++R K FK I NY E + +E EEL+I+ E+E+KI+ELA +I
Sbjct: 213 IVRVTGTLRTVRDERTK--RFKNFIYGNYTEFLEQEFEELQISEEDEEKIKELAGDPNIY 270
Query: 280 DAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ I+ S AP+I+GYREVK+ IAL LFGG + L D TRLRGDIH+L+VGDPG+ K
Sbjct: 271 EKIIRSTAPSIHGYREVKEAIALQLFGGTGKELDDKTRLRGDIHILIVGDPGIGK 325
>gb|AAK41071.1| Minichromosome maintenance protein MCM [Sulfolobus solfataricus]
Length = 686
Score = 291 bits (737), Expect = 3e-77
Identities = 168/320 (52%), Positives = 220/320 (68%), Gaps = 8/320 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVR++ TG + LEAGALVLADGG A+IDE+DKM D+DR IHEA+EQQT+S++KAGI
Sbjct: 374 TAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRVAIHEAMEQQTVSIAKAGI 433
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR VIAA NPK GR+ + +S+ INLPPT++SRFDLIF+L D+P E+ D E+A
Sbjct: 434 VAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFILKDQPGEQ-DRELA 492
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKS 973
+IL V G+S I D LRKYIAYARK V P I+ EA I ++V+MR KKS
Sbjct: 493 NYILDVHSGKS--TKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMR---KKS 547
Query: 974 SEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD-ETG 1032
SE PI IT RQLEALIR+SEA+A+M L VTREDA AI +M L + VD E+G
Sbjct: 548 SETPDSPILITPRQLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDMESG 607
Query: 1033 QIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEAREIL 1092
+ID+ + G+ K+ +I++II+ L +SE AK+ DIL+EA++ GIEK ++L
Sbjct: 608 KIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSSE-CAKVKDILKEAQQVGIEKSNIEKLL 666
Query: 1093 EKLLEQGQIYMPENGYYRTV 1112
+ + G IY + Y+ V
Sbjct: 667 TDMRKSGIIYEAKPECYKKV 686
Score = 215 bits (541), Expect = 3e-54
Identities = 126/335 (37%), Positives = 202/335 (59%), Gaps = 12/335 (3%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
F+ FL + + YI +I +L+A K+S+ I + + SF+ LA E++ N + +
Sbjct: 14 FIEFLTTFKGNNNQNKYIERINELVAYR-KKSLIIEFSDVLSFNENLAYEIINNTKIILP 72
Query: 70 AAEDAI--QIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTE 127
E A+ I+ + + D+ ++H R +P+ + +++I + I KLI ++G++ +VT
Sbjct: 73 ILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKLITIDGILVKVTP 132
Query: 128 IKPFVSSAVF--VCKDCGHEMV--VQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKFVNF 182
+K + A + + DC E ++ E C KCG +L EK+K +++
Sbjct: 133 VKERIYKATYKHIHPDCMQEFEWPEDEEMPEVLEMPTICPKCGKPGQFRLIPEKTKLIDW 192
Query: 183 QMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE---KREKVPT 239
Q IQ+RPE + GQ+PR ++ IL DD+VD+A PGDRV V GIL + Q+ KR
Sbjct: 193 QKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIKQDSPVKRGSRAV 252
Query: 240 FKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKG 299
F ++V+ IE K ++E+ I+ E+E+KI++LAK I D I+ SIAP+IYG+ E+K+
Sbjct: 253 FDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEA 312
Query: 300 IALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ALALFGGVP+ L D TR+RGDIH+L++GDPG AK
Sbjct: 313 LALALFGGVPKVLED-TRIRGDIHILIIGDPGTAK 346
>emb|CAB57529.1| (Y18930) minichromosome maintenance (MCM) protein [Sulfolobus
solfataricus]
Length = 686
Score = 291 bits (737), Expect = 3e-77
Identities = 168/320 (52%), Positives = 220/320 (68%), Gaps = 8/320 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVR++ TG + LEAGALVLADGG A+IDE+DKM D+DR IHEA+EQQT+S++KAGI
Sbjct: 374 TAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRVAIHEAMEQQTVSIAKAGI 433
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR VIAA NPK GR+ + +S+ INLPPT++SRFDLIF+L D+P E+ D E+A
Sbjct: 434 VAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFILKDQPGEQ-DRELA 492
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKS 973
+IL V G+S I D LRKYIAYARK V P I+ EA I ++V+MR KKS
Sbjct: 493 NYILDVHSGKS--TKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMR---KKS 547
Query: 974 SEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD-ETG 1032
SE PI IT RQLEALIR+SEA+A+M L VTREDA AI +M L + VD E+G
Sbjct: 548 SETPDSPILITPRQLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDMESG 607
Query: 1033 QIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEAREIL 1092
+ID+ + G+ K+ +I++II+ L +SE AK+ DIL+EA++ GIEK ++L
Sbjct: 608 KIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSSE-CAKVKDILKEAQQVGIEKSNIEKLL 666
Query: 1093 EKLLEQGQIYMPENGYYRTV 1112
+ + G IY + Y+ V
Sbjct: 667 TDMRKSGIIYEAKPECYKKV 686
Score = 215 bits (541), Expect = 3e-54
Identities = 126/335 (37%), Positives = 202/335 (59%), Gaps = 12/335 (3%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
F+ FL + + YI +I +L+A K+S+ I + + SF+ LA E++ N + +
Sbjct: 14 FIEFLTTFKGNNNQNKYIERINELVAYR-KKSLIIEFSDVLSFNENLAYEIINNTKIILP 72
Query: 70 AAEDAI--QIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTE 127
E A+ I+ + + D+ ++H R +P+ + +++I + I KLI ++G++ +VT
Sbjct: 73 ILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKLITIDGILVKVTP 132
Query: 128 IKPFVSSAVF--VCKDCGHEMV--VQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKFVNF 182
+K + A + + DC E ++ E C KCG +L EK+K +++
Sbjct: 133 VKERIYKATYKHIHPDCMQEFEWPEDEEMPEVLEMPTICPKCGKPGQFRLIPEKTKLIDW 192
Query: 183 QMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE---KREKVPT 239
Q IQ+RPE + GQ+PR ++ IL DD+VD+A PGDRV V GIL + Q+ KR
Sbjct: 193 QKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIKQDSPVKRGSRAV 252
Query: 240 FKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKG 299
F ++V+ IE K ++E+ I+ E+E+KI++LAK I D I+ SIAP+IYG+ E+K+
Sbjct: 253 FDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEA 312
Query: 300 IALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ALALFGGVP+ L D TR+RGDIH+L++GDPG AK
Sbjct: 313 LALALFGGVPKVLED-TRIRGDIHILIIGDPGTAK 346
>emb|CAC11929.1| (AL445065) DNA replication licensing factor MCM related protein
[Thermoplasma acidophilum]
Length = 698
Score = 271 bits (686), Expect = 3e-71
Identities = 158/354 (44%), Positives = 228/354 (63%), Gaps = 28/354 (7%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEF-TGGWVLEAGALVLADGGYALIDELDKMN 830
++ +++ G +F TAA VRDEF G W LEAGALVLAD G+ IDELDKM+
Sbjct: 349 YMAEVSPRGIFTFGRGSSAAGLTAAAVRDEFGEGRWTLEAGALVLADNGFVAIDELDKMD 408
Query: 831 DKDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTL 890
+ D + +HEA+EQQT+++SKAGI ATL AR +V+AAANPK GR++ + ++EQIN P L
Sbjct: 409 EHDTAAMHEAMEQQTVTISKAGIMATLKARASVLAAANPKFGRYDLNRNLAEQINFPLPL 468
Query: 891 MSRFDLIFVLVDEPDEKIDSEIARHILRVRR-GE---------------SEVVTPKIPHD 934
+SRFD+IF +VD P++ DS +A H+L+ R GE + P+I D
Sbjct: 469 LSRFDVIFKMVDHPNKDSDSRLAEHVLKAHRIGEIYRSIEHSDADIEIDEQGFEPEIDKD 528
Query: 935 LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRL 994
LRKY+AYAR NV P +S+EA+ ++ YVK R + + IPIT RQLE+ IRL
Sbjct: 529 TLRKYVAYARNNVFPRLSDEAIAILQDQYVKTRSTSHDA-------IPITVRQLESTIRL 581
Query: 995 SEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSARKLSKVERI 1054
+EA AR RLS IVT EDA A K+++Y L +++D G++D+ I+ G S+++ + +E +
Sbjct: 582 AEAAARARLSTIVTVEDALLAKKIVDYYLMDVSMD-NGKMDIDIIYTGASSKQRNDMETV 640
Query: 1055 LDIIEKLEGTSEKG-AKIDDILEEAKKFGIEKQEAREILEKLLEQGQIYMPENG 1107
LDII++L+ SEKG A++ D++ A G+ +++A E L KL GQI+ G
Sbjct: 641 LDIIKQLK--SEKGMAEVADVINVAMSRGMTQKKAEEALLKLKNAGQIFEKSYG 692
Score = 178 bits (447), Expect = 3e-43
Identities = 106/307 (34%), Positives = 172/307 (55%), Gaps = 14/307 (4%)
Query: 40 RSIAINWMHLNSFDPELAEEVLENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLP 99
R++ +++ L ++ + A +L +PE I A E+ I D + + + R +L
Sbjct: 39 RTLYVSFRDLEDYNWQFAGSILVSPEIYIRAGEEVILQDYLLDRVTQRFNIFNLRIKDLE 98
Query: 100 K---TLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGF 156
+ +++I + +I LI V G+V + TE+ P + +A F C C H + ++
Sbjct: 99 EKNVAYRIRDIRSANIGTLISVSGIVRKNTEVFPKLKNAAFECSSC-HGLTYVEQTENRL 157
Query: 157 VAVKKCEKCGSKN------VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDD 210
+ C+ CG +L S+F++ Q IQ+ PETL+GG P+ I I DD
Sbjct: 158 SEPQVCDHCGLSRGKDKIFFKLRPNLSEFIDVQKVEIQEDPETLEGGSQPQRITIITEDD 217
Query: 211 IVDTAMPGDRVVVVGILRVVQEKREKVPT---FKKVIEVNYIEPVSKEIEELEITPEEEQ 267
+ PG+RV+V GILR Q ++ +P F + +N + V KE+E ++IT E+++
Sbjct: 218 LAGLLYPGNRVIVDGILRTEQRRQGNIPLTEFFTYLYAINVRKDV-KELESVKITEEDKK 276
Query: 268 KIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLV 327
+I E++K+ DI+D I SIAP I+G VKK +AL +FGGV + + DGT +RGDIH+L+V
Sbjct: 277 RIIEISKKPDIIDVISRSIAPTIHGLDMVKKALALQMFGGVRKVMKDGTTMRGDIHILMV 336
Query: 328 GDPGVAK 334
GDPG AK
Sbjct: 337 GDPGTAK 343
>pir||B72775 probable DNA replication licensing factor mcm APE0188 - Aeropyrum
pernix (strain K1) >gi|5103579|dbj|BAA79100.1| (AP000058)
699aa long hypothetical DNA replication licensing factor
mcm [Aeropyrum pernix]
Length = 699
Score = 263 bits (666), Expect = 6e-69
Identities = 147/324 (45%), Positives = 212/324 (65%), Gaps = 6/324 (1%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV+RD TG + LEAGALVLADGG A+IDE DKM+ +DR VIHEA+EQQT+S++KAGI
Sbjct: 377 TAAVLRDPRTGEYFLEAGALVLADGGIAVIDEFDKMSKEDRGVIHEAMEQQTVSIAKAGI 436
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATL+AR +++AA NPK G ++ + + ++LP ++SRFDLIFV+ D + D +A
Sbjct: 437 KATLSARASLLAAGNPKFGYYDPSRSFVDNVDLPAPIISRFDLIFVVRDVIERSRDEMLA 496
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKS-VKK 972
++L E+ P+I DLLRKYIA+ARK+V P ++ +A + ++ +YV+MR S +
Sbjct: 497 SYVLETHT-NVELFKPEIDPDLLRKYIAFARKHVKPRLTPQAKKLLKDFYVEMRSSALHH 555
Query: 973 SSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD-ET 1031
SS+E KP+PIT RQLEALIRL+EAHARM L T EDA AI++M L+ I +D ET
Sbjct: 556 SSQEGAKPVPITTRQLEALIRLTEAHARMSLKQEATEEDAIAAIRIMTSVLQSIGLDLET 615
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKG---AKIDDILEEAKKFGIEKQEA 1088
G+ID+ I+ G S R + +LD+I+ + G + +I+ + I +++
Sbjct: 616 GEIDIGIIMTGASFRSRKIMSEVLDLIKSIVEEERGGQGCVRASEIVRRLGEKNIPEEKV 675
Query: 1089 REILEKLLEQGQIYMPENGYYRTV 1112
R+ ++KL QG I Y+ V
Sbjct: 676 RDAIDKLYRQGLIIEIRTECYKAV 699
Score = 196 bits (494), Expect = 9e-49
Identities = 121/334 (36%), Positives = 188/334 (56%), Gaps = 9/334 (2%)
Query: 8 ERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEEC 67
ERF FL + E + Y+ I+ ++ + S+ + + L +DP L+E +LE P E
Sbjct: 18 ERFKTFLENFRTEEGKLKYVEAIRRMINYE-ETSLEVEFKDLYRYDPLLSEILLEKPREF 76
Query: 68 ILAAEDAIQIILKEDIMREDVPRIHA-RFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVT 126
+ A +A++ I+ ++ R+ RF L T +++IG++H+ KL+Q+ G+VTR+
Sbjct: 77 LKEASEALKEIVAQESPEYAQGRVFTPRFTGLFDTERIRDIGSDHVGKLVQINGIVTRMH 136
Query: 127 EIKPFVSSAVFVCKDCGHEMV----VQQKPYEGFVAVKKCEKCGSKNVQLDV--EKSKFV 180
+ A F CG E + E C CG + + +KS ++
Sbjct: 137 PRATRMVRARFRHDRCGAEFWWPANEDEVLGERIERPSICPVCGEGGGKFTLVRDKSLYI 196
Query: 181 NFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTF 240
++Q +Q+RPE + GGQ+PR I+ L D+V+ PGDRV +VG++ + Q +
Sbjct: 197 DWQKIMVQERPEDVPGGQIPRSIEVHLSRDLVEKVRPGDRVKIVGVVGL-QSFSSSSTLY 255
Query: 241 KKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGI 300
+E N I K +EE+ IT E+E+KI +L++ I + I+ SIAP IYG+ ++K+ I
Sbjct: 256 SLYMEANSILLEEKILEEVSITREDEEKILQLSRDPWIKEKIIASIAPTIYGHWDLKEAI 315
Query: 301 ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
AL LFGGVP+ PDGTR RGDIHVL VGDPGVAK
Sbjct: 316 ALLLFGGVPKQRPDGTRTRGDIHVLFVGDPGVAK 349
>gi|6325276 Involved in initiation of DNA replication; Cdc54p [Saccharomyces
cerevisiae] >gi|1168816|sp|P30665|CC54_YEAST CELL
DIVISION CONTROL PROTEIN 54 >gi|1084526|pir||S56050
replication licensing factor MCM4 [validated] - yeast
(Saccharomyces cerevisiae) >gi|608171|gb|AAA86310.1|
(U14731) Cdc54p [Saccharomyces cerevisiae]
>gi|887597|emb|CAA90164.1| (Z49919) unknown
[Saccharomyces cerevisiae] >gi|1314093|emb|CAA95015.1|
(Z71255) Cdc54p [Saccharomyces cerevisiae]
Length = 933
Score = 241 bits (609), Expect = 3e-62
Identities = 135/349 (38%), Positives = 220/349 (62%), Gaps = 9/349 (2%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V+ +T G ++ V TA + RD T VLE+GALVL+DGG IDE DKM+D
Sbjct: 580 YVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSD 639
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQTIS++KAGI TLNAR++++A+ANP R+N ++E I+LPP L+
Sbjct: 640 STRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLL 699
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRV---RRGESEVVTPKIPHDLLRKYIAYARKNVH 948
SRFDL+++++D+ DEK D E+A+H+ + + E +P + L YI+YA++++H
Sbjct: 700 SRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIH 759
Query: 949 PVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVT 1008
P+I+E A E+ + YV MRK S +E K I T RQLE++IRL+EAHA+M+L +V
Sbjct: 760 PIITEAAKTELVRAYVGMRKMGDDSRSDE-KRITATTRQLESMIRLAEAHAKMKLKNVVE 818
Query: 1009 REDAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSA--RKLSK--VERILDIIEKLEG 1063
ED +EA++L+ ++ A D +TG+ID+ +++ G+S RKL + I+++++
Sbjct: 819 LEDVQEAVRLIRSAIKDYATDPKTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQAS 878
Query: 1064 TSEKGAKIDDILEEAKKFGIEKQEAREILEKLLEQGQIYMPENGYYRTV 1112
S ++ + E + +E + +E L +L ++ ++ + G R+V
Sbjct: 879 DSMSFNELIKQINEHSQDRVESSDIQEALSRLQQEDKVIVLGEGVRRSV 927
Score = 143 bits (356), Expect = 1e-32
Identities = 99/326 (30%), Positives = 164/326 (49%), Gaps = 53/326 (16%)
Query: 55 ELAEEVLENPEECILAAEDAIQ----IILKEDIMREDVPRIHARFY-----NLPKTLMVK 105
+L ++L P+E I + I+ ++ ++ + D+ I +FY N+ ++
Sbjct: 256 DLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMR 315
Query: 106 EIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQ------QKPYEGFVAV 159
E+ I+KLI ++G+V R T + P + A F C C H M V+ Q+P
Sbjct: 316 ELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEP------- 368
Query: 160 KKCEK--CGSKN-VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAM 216
+CE+ C N + L + F + Q+ ++Q+ P+ + GQ P I + D++VD+
Sbjct: 369 ARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCR 428
Query: 217 PGDRVVVVGILRVVQ---EKREKV--PTFKKVIEVNYIEPVS------------------ 253
GDR+ V G R + R++V +K ++V +++ VS
Sbjct: 429 AGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQN 488
Query: 254 ----KEIEEL-EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGV 308
E+EE+ +IT ++ KIRE+A R+D+ + SIAP+IY +VKKGI L LFGG
Sbjct: 489 KVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGT 548
Query: 309 PRTLPDGTRLRGDIHVLLVGDPGVAK 334
+T G R RGDI++LL GDP +K
Sbjct: 549 NKTFTKGGRYRGDINILLCGDPSTSK 574
>gb|AAD22296.1|AC007047_5 (AC007047) putative CDC21 protein [Arabidopsis thaliana]
Length = 720
Score = 237 bits (599), Expect = 4e-61
Identities = 141/318 (44%), Positives = 204/318 (63%), Gaps = 12/318 (3%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+++ L+ G ++ V TA V +D TG VLE+GALVL+D G IDE DKM+D
Sbjct: 393 YIHKLSPRGIYTSGRGSSAVGLTAYVAKDPETGETVLESGALVLSDRGICCIDEFDKMSD 452
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RS++HE +EQQT+S++KAGI A+LNART+V+A ANP R+N + E I+LPPTL+
Sbjct: 453 SARSMLHEVMEQQTVSIAKAGIIASLNARTSVLACANPSGSRYNPRLSVIENIHLPPTLL 512
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEVVTPK-IPHDLLRKYIAYARKNVHPV 950
SRFDLI++++D+PDE+ D +A+HI+ + +E + I L Y++YARKN+HP
Sbjct: 513 SRFDLIYLILDKPDEQTDRRLAKHIVALHFENAESAQEEAIDITTLTTYVSYARKNIHPK 572
Query: 951 ISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTRE 1010
+S+EA EE+ + YV++RK+ K + + K I T RQ+E+LIRLSEA ARMR S V +
Sbjct: 573 LSDEAAEELTRGYVELRKAGKFAGSSK-KVITATPRQIESLIRLSEALARMRFSEWVEKH 631
Query: 1011 DAREAIKLMEYTLRQIAVDE-TGQIDVTILEVGQSA----RKLSKVERILDI-IEKLEGT 1064
D EA +L+ ++Q A D TG ID+ ++ G SA R+ + I DI +EK+ T
Sbjct: 632 DVDEAFRLLRVAMQQSATDHATGTIDMDLINTGVSASERMRRDTFASSIRDIALEKI--T 689
Query: 1065 SEKGAKIDDILEEAKKFG 1082
E + +LEE KK G
Sbjct: 690 ME--MLLLQLLEELKKHG 705
Score = 148 bits (371), Expect = 2e-34
Identities = 107/358 (29%), Positives = 182/358 (49%), Gaps = 30/358 (8%)
Query: 2 DREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFD-----PEL 56
D + IE F++ RE E ++ GK +++I I W+ +++FD P+L
Sbjct: 35 DVKSAIEMFVKHFREARENSDDLFREGKY--MVSIRKVIEIEGEWIDVDAFDVFDYDPDL 92
Query: 57 AEEVLENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLI 116
+++ P E +LA D + + + I R + R +NL + ++ + I K+I
Sbjct: 93 YNKMVRYPLE-VLAIFDIVLMDIVSTINRLFEKHVQVRIFNLRTSTSMRNLNPSDIEKMI 151
Query: 117 QVEGVVTRVTEIKPFVSSAVFVCKDCGHE----MVVQQKPYEGFVAVKKCEKCGSKN-VQ 171
++G++ R + I P + AVF C CG+ +V + K E +K ++C +KN +
Sbjct: 152 SLKGMIIRSSSIIPEIREAVFRCLVCGYFSDPIIVDRGKISEPPTCLK--QECMTKNSMT 209
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQ 231
L + +F + Q+ R+Q+ P+ + G P + +L D +VD PGDR+ V GI R +
Sbjct: 210 LVHNRCRFADKQIVRLQETPDEIPEGGTPHTVSLLLHDKLVDNGKPGDRIEVTGIYRAMT 269
Query: 232 EK-----REKVPTFKKVIEVNYIEPVSK---------EIEE-LEITPEEEQKIRELAKRK 276
+ R FK I+ +I+ SK +++ L E+ +K +EL+K+
Sbjct: 270 VRVGPAHRTVKSVFKTYIDCLHIKKASKLRMSAEDPMDVDNSLRRVDEDLRKFQELSKQP 329
Query: 277 DIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
DI + + S+AP I+ +VKKG+ LFGG L G RGDI++LLVGDPG +K
Sbjct: 330 DIYERLSRSLAPNIWELDDVKKGLLCQLFGGNALNLASGANFRGDINILLVGDPGTSK 387
>gb|AAC26671.1| (AC004483) putative DNA replication licensing factor, mcm5
[Arabidopsis thaliana]
Length = 727
Score = 217 bits (547), Expect = 5e-55
Identities = 127/316 (40%), Positives = 192/316 (60%), Gaps = 18/316 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD T + LE GA+VLADGG IDE DKM +DR IHEA+EQQTIS++KAGI
Sbjct: 409 TASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGI 468
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T LN+RT+V+AAANP GR++ +K + I+L T++SRFDLIF++ D D EIA
Sbjct: 469 TTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDIRKYSQDKEIA 528
Query: 914 RHILRVRRGE---SEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
HI+RV S+ T + L++YI Y R HP +S++A E +++ YV +R +
Sbjct: 529 SHIIRVHASANKFSDENTDSKEDNWLKRYIQYCRARCHPRLSKDAAENLQRKYVTIRMDM 588
Query: 971 KKSSEE--EIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
K+ + E E PIPIT RQLEA++RLSE+ A+MRLS T +D +A KL + + A
Sbjct: 589 KRRAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHEATPDDVDKAFKLFDTSTMDAAR 648
Query: 1029 DETG-QIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEK 1085
QI++T G+ A ++ + E +++ GA++ + ++E+ + G+
Sbjct: 649 SGINQQINIT----GEMANEIKQAE------TQIKRRMGIGARLSERRLIEDLARMGMND 698
Query: 1086 QEAREILEKLLEQGQI 1101
R L + ++G++
Sbjct: 699 SMVRRALLIMHQRGEV 714
Score = 136 bits (340), Expect = 1e-30
Identities = 98/357 (27%), Positives = 176/357 (48%), Gaps = 34/357 (9%)
Query: 6 IIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPE 65
++ +F F+R + E Y ++ L PKR + ++ L SFD +L + P
Sbjct: 31 VLTKFKEFIRNFEIEQNCFPY----REALLDNPKR-LVVHLEDLLSFDSDLPSLIRSAPA 85
Query: 66 ECILAAEDAIQIIL---------KEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKL 115
+ + E A +L + +M E + R + + + ++ +GA++I+KL
Sbjct: 86 DYLPVFEKAAGEVLTGLKMREANEGGVMEEPLTRDVQILLTSREDPVSMRLLGAQYISKL 145
Query: 116 IQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKP-YEGFVAVKKCEKC---GSKNVQ 171
+++ G+ + +K + VCK+C V +P G + + C+ G +
Sbjct: 146 VKISGISIAASRVKAKATYVFLVCKNCKKTREVPCRPGLGGAIVPRSCDNIPQPGEEPCP 205
Query: 172 LDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGI 226
LD ++S++V+ Q ++Q+ PE + G++PR + + +V T +PG R+ V+GI
Sbjct: 206 LDPWMVVPDRSQYVDQQTLKLQENPEDVPTGELPRNMLLSVDRHLVQTIVPGTRLTVMGI 265
Query: 227 LRVVQEKREKVPTFKKVIEVN--YIEPVSKEIEE-------LEITPEEEQKIRELAKRKD 277
+ Q + K + + YI V E TP+EE++ ++ A +D
Sbjct: 266 YSIFQASSSS-NSHKGAVAIRQPYIRVVGLEDTNEASSRGPANFTPDEEEEFKKFADSQD 324
Query: 278 IVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ I IAP+I+G+ +VK+ A LFGG ++LPDG +LRGDI+VLL+GDP AK
Sbjct: 325 VYKNICTKIAPSIFGHEDVKRAAACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAK 381
>gb|AAF59242.1| (AE003841) dpa gene product [Drosophila melanogaster]
Length = 866
Score = 217 bits (547), Expect = 5e-55
Identities = 137/341 (40%), Positives = 200/341 (58%), Gaps = 20/341 (5%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V++L ++ V TA V +D T VL+ GALVLAD G IDE DKMND
Sbjct: 524 YVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMND 583
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+++AAANP + ++N+ K I + + LP TL+
Sbjct: 584 STRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLL 643
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILR---VRRGESEVVTPKIPHDLLRKYIAYARKNVH 948
SRFDLIF+++D DE D +A H++ V R E E +LR YIAYAR+++
Sbjct: 644 SRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEE--DTMFDMSVLRDYIAYAREHLS 701
Query: 949 PVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVT 1008
P +S+EA + + + YV MRK + +I P RQLE+LIRLSEAHA++RLS V
Sbjct: 702 PTLSDEAQQRLIQAYVDMRK--VGAGRGQISAYP---RQLESLIRLSEAHAKVRLSNQVE 756
Query: 1009 REDAREAIKLMEYTLRQIAVDE-TGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEK 1067
D EA +L L+Q A D +G+IDV IL G S K ++ I+ E +K
Sbjct: 757 LLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIK--ENLKKK 814
Query: 1068 G-------AKIDDILEEAKKFGIEKQEAREILEKLLEQGQI 1101
G K+ ++E + I +++ + L+++ ++G I
Sbjct: 815 GKVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQDEGAI 855
Score = 138 bits (344), Expect = 3e-31
Identities = 101/349 (28%), Positives = 174/349 (48%), Gaps = 28/349 (8%)
Query: 11 LRFLREYAEEGE--------EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
+RF+ AE+ E +PLY+ K++++ + + + +N HL +FD +L +++
Sbjct: 173 MRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLE-EPYLNLNCAHLKTFDQDLYRQLIC 231
Query: 63 NPEECILAAEDAIQIILKEDIMREDVP-RIHARFYNLPKTLMVKEIGAEHINKLIQVEGV 121
P+E I + AI + E + +I R +N KT ++ + E +++LI + G+
Sbjct: 232 YPQEVIPGFDMAINEMFFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGM 291
Query: 122 VTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKNV-QLDVEKSKF 179
V R + + P + A F C C V+ G + C C + + +L +S+F
Sbjct: 292 VIRSSNVIPEMREAFFSCNICSFSTTVEVD--RGRINQPTLCTNCNTNHCFRLIHNRSEF 349
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPT 239
+ Q+ ++Q+ P+ + GQ P + +D+VD PGDRV V GI R K + +
Sbjct: 350 TDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSS 409
Query: 240 FKKVIEVNYIEPV------SKEIEELE------ITPEEEQKIRELAKRKDIVDAIVDSIA 287
K + +++ V +K + E E PE + ++ LAK+ DI D + +IA
Sbjct: 410 SVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIA 469
Query: 288 PAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
P+IY ++KKGI L LFGG + R R +IH+LL GDPG +K
Sbjct: 470 PSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSK 518
>gb|AAA91232.1| (U46131) DNA replication initiator protein [Xenopus laevis]
Length = 863
Score = 217 bits (547), Expect = 5e-55
Identities = 127/292 (43%), Positives = 180/292 (61%), Gaps = 7/292 (2%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V++L G ++ V TA V++D T VL+ GALVL+D G IDE DKMN+
Sbjct: 522 YVFNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNE 581
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+V+AAANP + ++N K E I LP TL+
Sbjct: 582 STRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENIQLPHTLL 641
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRV-RRGESEVVTPKIPHDLLRKYIAYARKNVHPV 950
SRFDLIF+++D DE D +A H++ + + E ++ + +L+ YIAYAR V+P
Sbjct: 642 SRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEEQMKEEHLDMAVLKDYIAYARTYVNPR 701
Query: 951 ISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTRE 1010
+SEEA + + + YV MRK S + P RQLE+LIRLSEAHA++R S V
Sbjct: 702 LSEEASQALIEAYVSMRKI--GSGRGMVSAYP---RQLESLIRLSEAHAKVRFSNKVETI 756
Query: 1011 DAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKL 1061
D EA +L L+Q A D TG +D++IL G SA + E + +++KL
Sbjct: 757 DVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATARKRKEELAQVLKKL 808
Score = 138 bits (344), Expect = 3e-31
Identities = 103/358 (28%), Positives = 178/358 (48%), Gaps = 36/358 (10%)
Query: 8 ERFLRFLREYAEEG-----------EEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPEL 56
E+F RF++ + + EP+Y+ +++++ + + I+ HL +FD +L
Sbjct: 164 EKFQRFVQRFIDPSAKEEDNVGLDLNEPIYMQRLEEINVVGDP-FLNIDCDHLRNFDQDL 222
Query: 57 AEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHARFYNLPKTLMVKEIGAEHIN 113
+++ P+E I + A I E D + E +I R YN KT ++ + E I+
Sbjct: 223 YRQLVCYPQEVIPTFDMAANEIFFERYPDSILEH--QIQVRPYNALKTRNMRSLNPEDID 280
Query: 114 KLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKN-VQ 171
+LI + G+V R ++I P + A F C+ C V+ G +A C+ C + + +
Sbjct: 281 QLITISGMVIRTSQIIPEMQEAFFKCQVCAFTTRVEID--RGRIAEPSVCKHCNTTHSMA 338
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQ 231
L +S F + QM ++Q+ PE + GQ P +D+VD PGDRV V GI R V
Sbjct: 339 LIHNRSMFSDKQMIKLQESPEDMPAGQTPHTTILYGHNDLVDKVQPGDRVNVTGIYRAVP 398
Query: 232 EK-----REKVPTFKKVIEVNY--------IEPVSKEIEELEITPEEEQKIRELAKRKDI 278
+ R +K I+V + + + ++ E+ T E ++ELA + DI
Sbjct: 399 IRVNPRVRNVKSVYKTHIDVIHYRKTDSKRLHGIDEDTEQKLFTEERVAMLKELAAKPDI 458
Query: 279 VDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
+ + ++AP+IY + ++KKGI L LFGG + R R ++++LL GDPG +K
Sbjct: 459 YERLAAALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEVNILLCGDPGTSK 516
>sp|Q26454|MCM4_DROME DNA REPLICATION LICENSING FACTOR MCM4 (DISC PROLIFERATION ABNORMAL
PROTEIN) >gi|2133664|pir||S59872 replication licensing
factor MCM4 - fruit fly (Drosophila melanogaster)
>gi|1245870|gb|AAB35644.1| (S80255) replication factors
MCM=dpa [Drosophila, Peptide, 866 aa] [Drosophila sp.]
Length = 866
Score = 217 bits (547), Expect = 5e-55
Identities = 137/341 (40%), Positives = 200/341 (58%), Gaps = 20/341 (5%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V++L ++ V TA V +D T VL+ GALVLAD G IDE DKMND
Sbjct: 524 YVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMND 583
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+++AAANP + ++N+ K I + + LP TL+
Sbjct: 584 STRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLL 643
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILR---VRRGESEVVTPKIPHDLLRKYIAYARKNVH 948
SRFDLIF+++D DE D +A H++ V R E E +LR YIAYAR+++
Sbjct: 644 SRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEE--DTMFDMSVLRDYIAYAREHLS 701
Query: 949 PVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVT 1008
P +S+EA + + + YV MRK + +I P RQLE+LIRLSEAHA++RLS V
Sbjct: 702 PTLSDEAQQRLIQAYVDMRK--VGAGRGQISAYP---RQLESLIRLSEAHAKVRLSNQVE 756
Query: 1009 REDAREAIKLMEYTLRQIAVDE-TGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEK 1067
D EA +L L+Q A D +G+IDV IL G S K ++ I+ E +K
Sbjct: 757 LLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIK--ENLKKK 814
Query: 1068 G-------AKIDDILEEAKKFGIEKQEAREILEKLLEQGQI 1101
G K+ ++E + I +++ + L+++ ++G I
Sbjct: 815 GKVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQDEGAI 855
Score = 138 bits (345), Expect = 3e-31
Identities = 100/349 (28%), Positives = 175/349 (49%), Gaps = 28/349 (8%)
Query: 11 LRFLREYAEEGE--------EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
+RF+ AE+ E +PLY+ K++++ + + + +N HL +FD +L +++
Sbjct: 173 MRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLE-EPYLNLNCAHLKTFDQDLYRQLIC 231
Query: 63 NPEECILAAEDAIQIILKEDIMREDVP-RIHARFYNLPKTLMVKEIGAEHINKLIQVEGV 121
P+E I + AI + E + +I R +N KT ++ + E +++LI + G+
Sbjct: 232 YPQEVIPGFDMAINEMFFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGM 291
Query: 122 VTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKNV-QLDVEKSKF 179
V R + + P + A F C C V+ G + C C + + +L +S+F
Sbjct: 292 VIRSSNVIPEMREAFFSCNICSFSTTVEVD--RGRINQPTLCTNCNTNHCFRLIHNRSEF 349
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPT 239
+ Q+ ++Q+ P+ + GQ P + +D+VD PGDRV V GI R K + +
Sbjct: 350 TDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSS 409
Query: 240 FKKVIEVNYIEPVS-KEIEELEITPEEEQK-----------IRELAKRKDIVDAIVDSIA 287
K + +++ V ++++ + EEE K ++ LAK+ DI D + +IA
Sbjct: 410 SVKSVYKTHVDVVHFRKVDNKRLYEEEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIA 469
Query: 288 PAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
P+IY ++KKGI L LFGG + R R +IH+LL GDPG +K
Sbjct: 470 PSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSK 518
>pir||T47223 replication licensing factor MCM4 [validated] - African clawed frog
>gi|2231173|gb|AAC60225.1| (U44049) cdc21p [Xenopus
laevis]
Length = 858
Score = 216 bits (545), Expect = 9e-55
Identities = 127/292 (43%), Positives = 178/292 (60%), Gaps = 7/292 (2%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+VY+L G ++ V TA V++D T VL+ GALVL+D G IDE DKMN+
Sbjct: 517 YVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNE 576
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+V+AAANP + ++N K E I LP TL+
Sbjct: 577 STRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENIQLPHTLL 636
Query: 892 SRFDLIFVLVDEPDEKIDSEIARH-ILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPV 950
SRFDLIF+++D DE D +A H ++ + E ++ + +L+ YIAYAR V+P
Sbjct: 637 SRFDLIFLMLDPQDETYDRRLAHHLVVLYYQSEEQLKEEHLDMAVLKDYIAYARTYVNPR 696
Query: 951 ISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTRE 1010
+ EEA + + + YV MRK S + P RQLE+LIRLSEAHA++R S V
Sbjct: 697 LGEEASQALIEAYVDMRKI--GSGRGMVSAYP---RQLESLIRLSEAHAKVRFSSKVETI 751
Query: 1011 DAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKL 1061
D EA +L L+Q A D TG +D++IL G SA + E + +++KL
Sbjct: 752 DVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATARKRKEELAQVLKKL 803
Score = 139 bits (346), Expect = 2e-31
Identities = 106/359 (29%), Positives = 182/359 (50%), Gaps = 33/359 (9%)
Query: 4 EEIIERFL-RFLREYAEEGE-------EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPE 55
+E +RF+ RF+ A+E E EP+Y+ +++++ + + + I+ HL SFD +
Sbjct: 158 KEKFQRFVQRFIDPLAKEEENVGLDLNEPIYMQRLEEI-NVVGEPFLNIDCDHLRSFDQD 216
Query: 56 LAEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHARFYNLPKTLMVKEIGAEHI 112
L +++ P+E I + A I E D + E +I R YN KT ++ + E I
Sbjct: 217 LYRQLVCYPQEVIPTFDMAANEIFFERYPDSILEH--QIQVRPYNALKTRNMRSLNPEDI 274
Query: 113 NKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKN-V 170
++LI + G+V R ++I P + + F C+ C V+ G +A C+ C + + +
Sbjct: 275 DQLITISGMVIRTSQIIPEMQESFFKCQVCAFTTRVEID--RGRIAEPSVCKHCNTTHSM 332
Query: 171 QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV 230
L +S F + QM ++Q+ P + GQ P +D+VD PGDRV V GI R V
Sbjct: 333 ALIHNRSMFSDKQMIKLQESPGDMPAGQTPHTTILYAHNDLVDKVQPGDRVNVTGIYRAV 392
Query: 231 QEK-----REKVPTFKKVIEVNY--------IEPVSKEIEELEITPEEEQKIRELAKRKD 277
+ R +K I+V + + + ++ E+ T E ++ELA + D
Sbjct: 393 PIRVNPRVRNVKSVYKTHIDVIHYRKTDSKRLHGIDEDTEQKMFTEERVAVLKELAAKPD 452
Query: 278 IVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
I + + ++AP+IY + ++KKGI L LFGG + R R ++++LL GDPG +K
Sbjct: 453 IYERLAAALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEVNILLCGDPGTSK 511
>sp|P33991|MCM4_HUMAN DNA REPLICATION LICENSING FACTOR MCM4 (CDC21 HOMOLOG) (P1-CDC21)
>gi|7428558|pir||S65954 replication licensing factor MCM4
- human
Length = 863
Score = 216 bits (545), Expect = 9e-55
Identities = 127/292 (43%), Positives = 179/292 (60%), Gaps = 7/292 (2%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+VY+L G ++ V TA V++D T VL+ GALVL+D G IDE DKMN+
Sbjct: 522 YVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNE 581
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+V+AAANP + ++N K E I LP TL+
Sbjct: 582 STRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLL 641
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRV-RRGESEVVTPKIPHDLLRKYIAYARKNVHPV 950
SRFDLIF+++D DE D +A H++ + + E + + +L+ YIAYA + P
Sbjct: 642 SRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPR 701
Query: 951 ISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTRE 1010
+SEEA + + + YV MRK SS + P RQLE+LIRL+EAHA++RLS V
Sbjct: 702 LSEEASQALIEAYVDMRKI--GSSRGMVSAYP---RQLESLIRLAEAHAKVRLSNKVEAI 756
Query: 1011 DAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKL 1061
D EA +L L+Q A D TG +D++IL G SA + E + + ++KL
Sbjct: 757 DVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKL 808
Score = 150 bits (375), Expect = 8e-35
Identities = 108/359 (30%), Positives = 189/359 (52%), Gaps = 33/359 (9%)
Query: 4 EEIIERFL-RFLREYAEEGE-------EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPE 55
+E +RFL RF+ A+E E EPLY+ ++ ++ I ++ + +N H+ SFD
Sbjct: 163 KENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIG-EQFLNVNCEHIKSFDKN 221
Query: 56 LAEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHARFYNLPKTLMVKEIGAEHI 112
L +++ P+E I + A+ I + D + E +I R +N KT ++ + E I
Sbjct: 222 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEH--QIQVRPFNALKTKNMRNLNPEDI 279
Query: 113 NKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKN-V 170
++LI + G+V R +++ P + A F C+ C H V+ G +A C +C + + +
Sbjct: 280 DQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMD--RGRIAEPSVCGRCHTTHSM 337
Query: 171 QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV 230
L +S F + QM ++Q+ PE + GQ P + +D+VD PGDRV V GI R V
Sbjct: 338 ALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAV 397
Query: 231 QEK-REKVPTFKKVIE-----VNYIEPVSKEIEELEITPEEE-------QKIRELAKRKD 277
+ +V K V + ++Y + +K + L+ E++ + ++EL+++ D
Sbjct: 398 PIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPD 457
Query: 278 IVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
I + + ++AP+IY + ++KKGI L LFGG + R R +I++LL GDPG +K
Sbjct: 458 IYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSK 516
>emb|CAA52801.1| (X74794) P1 Cdc21 protein [Homo sapiens] >gi|1098112|prf||2115257A
Cdc21-like protein [Homo sapiens]
Length = 923
Score = 216 bits (545), Expect = 9e-55
Identities = 127/292 (43%), Positives = 179/292 (60%), Gaps = 7/292 (2%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+VY+L G ++ V TA V++D T VL+ GALVL+D G IDE DKMN+
Sbjct: 582 YVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNE 641
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+V+AAANP + ++N K E I LP TL+
Sbjct: 642 STRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLL 701
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRV-RRGESEVVTPKIPHDLLRKYIAYARKNVHPV 950
SRFDLIF+++D DE D +A H++ + + E + + +L+ YIAYA + P
Sbjct: 702 SRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPR 761
Query: 951 ISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTRE 1010
+SEEA + + + YV MRK SS + P RQLE+LIRL+EAHA++RLS V
Sbjct: 762 LSEEASQALIEAYVDMRKI--GSSRGMVSAYP---RQLESLIRLAEAHAKVRLSNKVEAI 816
Query: 1011 DAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKL 1061
D EA +L L+Q A D TG +D++IL G SA + E + + ++KL
Sbjct: 817 DVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKL 868
Score = 150 bits (375), Expect = 8e-35
Identities = 108/359 (30%), Positives = 189/359 (52%), Gaps = 33/359 (9%)
Query: 4 EEIIERFL-RFLREYAEEGE-------EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPE 55
+E +RFL RF+ A+E E EPLY+ ++ ++ I ++ + +N H+ SFD
Sbjct: 223 KENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIG-EQFLNVNCEHIKSFDKN 281
Query: 56 LAEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHARFYNLPKTLMVKEIGAEHI 112
L +++ P+E I + A+ I + D + E +I R +N KT ++ + E I
Sbjct: 282 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEH--QIQVRPFNALKTKNMRNLNPEDI 339
Query: 113 NKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKN-V 170
++LI + G+V R +++ P + A F C+ C H V+ G +A C +C + + +
Sbjct: 340 DQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMD--RGRIAEPSVCGRCHTTHSM 397
Query: 171 QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV 230
L +S F + QM ++Q+ PE + GQ P + +D+VD PGDRV V GI R V
Sbjct: 398 ALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAV 457
Query: 231 QEK-REKVPTFKKVIE-----VNYIEPVSKEIEELEITPEEE-------QKIRELAKRKD 277
+ +V K V + ++Y + +K + L+ E++ + ++EL+++ D
Sbjct: 458 PIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPD 517
Query: 278 IVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
I + + ++AP+IY + ++KKGI L LFGG + R R +I++LL GDPG +K
Sbjct: 518 IYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSK 576
>gi|6678828 mini chromosome maintenance deficient 4 homolog (S. cerevisiae) [Mus
musculus] >gi|1705521|sp|P49717|MCM4_MOUSE DNA
REPLICATION LICENSING FACTOR MCM4 (CDC21 HOMOLOG)
(P1-CDC21) >gi|1363105|pir||S56766 replication licensing
factor MCM4 - mouse >gi|940406|dbj|BAA05082.1| (D26089)
mcdc21 protein [Mus musculus]
Length = 862
Score = 216 bits (544), Expect = 1e-54
Identities = 127/292 (43%), Positives = 178/292 (60%), Gaps = 7/292 (2%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+VY+L G ++ V TA V++D T VL+ GALVL+D G IDE DKMN+
Sbjct: 521 YVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNE 580
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+V+AAANP + ++N K E I LP TL+
Sbjct: 581 STRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLL 640
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRV-RRGESEVVTPKIPHDLLRKYIAYARKNVHPV 950
SRFDLIF+++D DE D +A H++ + + E +V + +L+ YIAYA + P
Sbjct: 641 SRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEEEFLDMAVLKDYIAYAHSTIMPR 700
Query: 951 ISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTRE 1010
+SEEA + + + YV MRK SS + P RQLE+LIRL+EAHA++R S V
Sbjct: 701 LSEEASQALIEAYVNMRKI--GSSRGMVSAYP---RQLESLIRLAEAHAKVRFSNKVEAI 755
Query: 1011 DAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKL 1061
D EA +L L+Q A D TG +D++IL G SA + E + + + KL
Sbjct: 756 DVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKL 807
Score = 143 bits (356), Expect = 1e-32
Identities = 110/361 (30%), Positives = 186/361 (51%), Gaps = 37/361 (10%)
Query: 4 EEIIERFLR-FLREYAEEGE-------EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPE 55
+E +RFL+ F A+E E +PLY+ ++ ++ IT + + +N H+ SF
Sbjct: 162 KENFQRFLQCFTDPLAKEEENVGIDITQPLYMQQLGEI-NITGEPFLNVNCEHIKSFSKN 220
Query: 56 LAEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHARFYNLPKTLMVKEIGAEHI 112
L +++ P+E I + A+ I + D + E +I R +N KT ++ + E I
Sbjct: 221 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEH--QIQVRPFNALKTKSMRNLNPEDI 278
Query: 113 NKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVK-KCEKCGSKN-V 170
++LI + G+V R +++ P + A F C+ C H V+ G +A C C + + +
Sbjct: 279 DQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEID--RGRIAEPCSCVHCHTTHSM 336
Query: 171 QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV 230
L +S F + QM ++Q+ PE + GQ P I +D+VD PGDRV V GI R V
Sbjct: 337 ALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLFAHNDLVDKVQPGDRVNVTGIYRAV 396
Query: 231 QEK-REKVPTFKKVIE-----VNYIEPVSKEIEELEITPEEEQKI---------RELAKR 275
+ +V K V + ++Y + +K + L+ E EQK+ +EL+++
Sbjct: 397 PIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLD--EEAEQKLFSEKRVKLLKELSRK 454
Query: 276 KDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVA 333
DI + + ++AP+IY + ++KKGI L LFGG + R R +I++LL GDPG +
Sbjct: 455 PDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTS 514
Query: 334 K 334
K
Sbjct: 515 K 515
>sp|Q58884|YE89_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ1489 >gi|2127802|pir||H64485
replication licensing factor MCM-type homolog MJ1489 -
Methanococcus jannaschii >gi|1592127|gb|AAB99502.1|
(U67590) cell division control protein 47 (cdc47)
[Methanococcus jannaschii]
Length = 682
Score = 215 bits (543), Expect = 2e-54
Identities = 142/334 (42%), Positives = 200/334 (59%), Gaps = 32/334 (9%)
Query: 794 TAAVVRDEFTGG---WVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSK 850
TAAVVR++ G WV++ G LV A G A IDEL +N + +S + EA+E QTI +SK
Sbjct: 362 TAAVVREKTEIGEDTWVIKPGLLVKAHKGTACIDELT-VNKELQSYVLEAMESQTIHISK 420
Query: 851 AGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDS 910
GI A L A ++AA NP+ GRFN ++EQIN+P L+SRFDLIF + D D+ D
Sbjct: 421 GGINAKLPAECAILAACNPRWGRFNPEVSVAEQINIPAPLLSRFDLIFPIRDVSDKDKDK 480
Query: 911 EIARHILRVRRG-------------ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAME 957
+IA +I+ + R EV KI + + KYI YAR+ P+ISE+A E
Sbjct: 481 DIAEYIVDLHRAYLDEKINREMGLDYLEVDGVKIDKEFIIKYIYYARQK-KPIISEKAKE 539
Query: 958 EIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIK 1017
YYV+MRK + ITARQLEA IR++EAHA+ +L +V EDA+EAI
Sbjct: 540 LFVNYYVEMRKKHQ-----------ITARQLEAAIRIAEAHAKAKLKDVVDEEDAKEAIN 588
Query: 1018 LMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILE 1076
++ L++IA D ETG DV + +G S ++ K+ + +II++L SE + +DI E
Sbjct: 589 IITECLKEIAYDPETGIFDVDKI-LGVSKKERDKLTTVYEIIKELSEKSEL-VEHEDIAE 646
Query: 1077 EAKKFGIEKQEAREILEKLLEQGQIYMPENGYYR 1110
EAKK GI++ E I++KL++ G I P+ G YR
Sbjct: 647 EAKKKGIKEDELENIIKKLIKYGDIDEPKPGRYR 680
Score = 105 bits (260), Expect = 2e-21
Identities = 63/237 (26%), Positives = 129/237 (53%), Gaps = 11/237 (4%)
Query: 100 KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAV 159
K +++I ++ + KL++ EG++ ++I+P + A ++C CG E VV++ +
Sbjct: 112 KIFTIEDIRSKTLGKLVEFEGIIVMASKIRPMLKKAYYICPKCGRE-VVREIDILNTDSE 170
Query: 160 KKCEKCGSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGD 219
K +CG++ + L KS + +FQ ++Q + ++ + P + L++ +
Sbjct: 171 KAVCECGAE-LNLIEHKSIYTDFQEIKVQQPLDLMENPEEPPKYITVFLEN--SPGIYAG 227
Query: 220 RVVVVGILRVVQEKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIV 279
RV + GI + +K +K+P + ++ + E + E+ ++++T + + I+++AKRKD+V
Sbjct: 228 RVKITGI-PIKVKKSKKLPIYDIHVKALHCEVLDGEV-KIKLTNSDIENIKKIAKRKDVV 285
Query: 280 DAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAKCV 336
+ + D + P I G+ +KK + L GV + R DIH+LL+ DPG+ K V
Sbjct: 286 NILADRLIPEIKGHSAIKKAVLLQQIKGVKK-----PGKRADIHILLITDPGIGKTV 337
>pir||T50408 cdc21 protein [imported] - fission yeast (Schizosaccharomyces pombe)
(fragment) >gi|7160246|emb|CAB76210.1| (AL157991) cdc21
protein [Schizosaccharomyces pombe]
Length = 407
Score = 213 bits (538), Expect = 6e-54
Identities = 119/280 (42%), Positives = 179/280 (63%), Gaps = 13/280 (4%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V+ + G ++ V TA + RD+ T VLE+GALVL+DGG IDE DKM+D
Sbjct: 53 YVHKIAPRGVYTSGKGSSAVGLTAYITRDQDTKQLVLESGALVLSDGGICCIDEFDKMSD 112
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RS++HE +EQQT++++KAGI TLNART+++A+ANP ++N +++ I+LPPTL+
Sbjct: 113 ATRSILHEVMEQQTVTVAKAGIITTLNARTSILASANPIGSKYNPDLPVTKNIDLPPTLL 172
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDL-------LRKYIAYAR 944
SRFDL+++++D DE +D ++A HI+ + + TP+ D+ L YI YAR
Sbjct: 173 SRFDLVYLILDRVDETLDRKLANHIVSMYMED----TPEHATDMEVFSVEFLTSYITYAR 228
Query: 945 KNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLS 1004
N++PVISEEA +E+ YV MRK + E K I T RQLE++IRLSEAHA+M L
Sbjct: 229 NNINPVISEEAAKELVNAYVGMRKLGEDVRASE-KRITATTRQLESMIRLSEAHAKMHLR 287
Query: 1005 PIVTREDAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQ 1043
+V D EA +L++ ++ A D TG+I + ++ V +
Sbjct: 288 NVVEVGDVLEAARLIKTAIKDYATDPATGKISLDLIYVNE 327
>sp|P29458|CC21_SCHPO CDC21 PROTEIN >gi|4165293|emb|CAA41628.1| (X58824) cdc21 protein
[Schizosaccharomyces pombe]
Length = 931
Score = 213 bits (538), Expect = 6e-54
Identities = 119/280 (42%), Positives = 179/280 (63%), Gaps = 13/280 (4%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V+ + G ++ V TA + RD+ T VLE+GALVL+DGG IDE DKM+D
Sbjct: 557 YVHKIAPRGVYTSGKGSSAVGLTAYITRDQDTKQLVLESGALVLSDGGICCIDEFDKMSD 616
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RS++HE +EQQT++++KAGI TLNART+++A+ANP ++N +++ I+LPPTL+
Sbjct: 617 ATRSILHEVMEQQTVTVAKAGIITTLNARTSILASANPIGSKYNPDLPVTKNIDLPPTLL 676
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDL-------LRKYIAYAR 944
SRFDL+++++D DE +D ++A HI+ + + TP+ D+ L YI YAR
Sbjct: 677 SRFDLVYLILDRVDETLDRKLANHIVSMYMED----TPEHATDMEVFSVEFLTSYITYAR 732
Query: 945 KNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLS 1004
N++PVISEEA +E+ YV MRK + E K I T RQLE++IRLSEAHA+M L
Sbjct: 733 NNINPVISEEAAKELVNAYVGMRKLGEDVRASE-KRITATTRQLESMIRLSEAHAKMHLR 791
Query: 1005 PIVTREDAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQ 1043
+V D EA +L++ ++ A D TG+I + ++ V +
Sbjct: 792 NVVEVGDVLEAARLIKTAIKDYATDPATGKISLDLIYVNE 831
Score = 150 bits (375), Expect = 8e-35
Identities = 116/389 (29%), Positives = 199/389 (50%), Gaps = 62/389 (15%)
Query: 4 EEIIERFLRFLR--------EYAEE------GEEPLYIGKIKDLLAITPKRSIAINWMHL 49
+E I F FLR EY E E+ +YI ++++ I + ++ L
Sbjct: 167 QESIASFRGFLRGFKKKYRPEYRNELMPPPDAEQLVYIEALRNM-RIMGLEILNLDVQDL 225
Query: 50 NSFDP--ELAEEVLENPEECILAAEDAIQIIL--------KEDIMREDVPRIHA-RFYNL 98
+ P +L ++ P+E I + I+ ++ ED++ + +I+ R +NL
Sbjct: 226 KHYPPTKKLYHQLYSYPQEIIPIMDQTIKDVMLDLLGTNPPEDVLNDIELKIYKIRPFNL 285
Query: 99 PKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVA 158
K + ++++ I+KLI ++G+V R T + P + A F C CGH + V+ G +A
Sbjct: 286 EKCINMRDLNPGDIDKLISIKGLVLRCTPVIPDMKQAFFRCSVCGHCVTVEID--RGRIA 343
Query: 159 VK-KC--EKCGSKN-VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDT 214
KC E CG+ N +QL +S+F + Q+ ++Q+ P+ + GQ P + + D++VD+
Sbjct: 344 EPIKCPREVCGATNAMQLIHNRSEFADKQVIKLQETPDVVPDGQTPHSVSLCVYDELVDS 403
Query: 215 AMPGDRVVVVGILRVV--------------------------QEKREKVPTFKKVIEVNY 248
A GDR+ V GI R V Q+KR ++ T +E +
Sbjct: 404 ARAGDRIEVTGIFRCVPVRLNPRMRTVKSLFKTYVDVVHIKKQDKR-RLGTDPSTLESDI 462
Query: 249 IEPVSKEIEEL-EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGG 307
E + +I+E+ +I+ EE +KI++++KR DI D + S+AP+IY +VKKG+ L LFGG
Sbjct: 463 AEDAALQIDEVRKISDEEVEKIQQVSKRDDIYDILSRSLAPSIYEMDDVKKGLLLQLFGG 522
Query: 308 VPRTLPDGT--RLRGDIHVLLVGDPGVAK 334
++ G R RGDI++L+ GDP +K
Sbjct: 523 TNKSFHKGASPRYRGDINILMCGDPSTSK 551
>sp|P30664|MCM4_XENLA DNA REPLICATION LICENSING FACTOR MCM4 (CDC21 HOMOLOG) (P1-CDC21)
(X.MCM4) >gi|2134046|pir||S64720 replication licensing
factor MCM4 - African clawed frog
>gi|1002598|gb|AAB01680.1| (U29178) Cdc21 [Xenopus
laevis]
Length = 863
Score = 213 bits (538), Expect = 6e-54
Identities = 125/292 (42%), Positives = 179/292 (60%), Gaps = 7/292 (2%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V++L G ++ V TA V++D T VL+ GALVL+D G IDE DKMN+
Sbjct: 522 YVFNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNE 581
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+V+AAANP + ++N K E I LP TL+
Sbjct: 582 STRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENIQLPHTLL 641
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRV-RRGESEVVTPKIPHDLLRKYIAYARKNVHPV 950
SRFDLIF+++D DE D +A H++ + + E ++ + +L+ YIAYAR V+P
Sbjct: 642 SRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEEQMKEEHLDMAVLKDYIAYARTYVNPR 701
Query: 951 ISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTRE 1010
+SEEA + + + YV MRK S + P RQLE+LIR +EAHA++R S V
Sbjct: 702 LSEEASQALIEAYVSMRKI--GSGRGMVSAYP---RQLESLIRRAEAHAKVRFSNKVETI 756
Query: 1011 DAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKL 1061
D EA +L L+Q A D TG +D++IL G SA + E + +++KL
Sbjct: 757 DVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATARKRKEELAQVLKKL 808
Score = 138 bits (344), Expect = 3e-31
Identities = 103/358 (28%), Positives = 178/358 (48%), Gaps = 36/358 (10%)
Query: 8 ERFLRFLREYAEEG-----------EEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPEL 56
E+F RF++ + + EP+Y+ +++++ + + I+ HL +FD +L
Sbjct: 164 EKFQRFVQRFIDPSAKEEDNVGLDLNEPIYMQRLEEINVVGDP-FLNIDCDHLRNFDQDL 222
Query: 57 AEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHARFYNLPKTLMVKEIGAEHIN 113
+++ P+E I + A I E D + E +I R YN KT ++ + E I+
Sbjct: 223 YRQLVCYPQEVIPTFDMAANEIFFERYPDSILEH--QIQVRPYNALKTRNMRSLNPEDID 280
Query: 114 KLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKN-VQ 171
+LI + G+V R ++I P + A F C+ C V+ G +A C+ C + + +
Sbjct: 281 QLITISGMVIRTSQIIPEMQEAFFKCQVCAFTTRVEID--RGRIAEPSVCKHCNTTHSMA 338
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQ 231
L +S F + QM ++Q+ PE + GQ P +D+VD PGDRV V GI R V
Sbjct: 339 LIHNRSMFSDKQMIKLQESPEDMPAGQTPHTTILYGHNDLVDKVQPGDRVNVTGIYRAVP 398
Query: 232 EK-----REKVPTFKKVIEVNY--------IEPVSKEIEELEITPEEEQKIRELAKRKDI 278
+ R +K I+V + + + ++ E+ T E ++ELA + DI
Sbjct: 399 IRVNPRVRNVKSVYKTHIDVIHYRKTDSKRLHGIDEDTEQKLFTEERVAMLKELAAKPDI 458
Query: 279 VDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
+ + ++AP+IY + ++KKGI L LFGG + R R ++++LL GDPG +K
Sbjct: 459 YERLAAALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEVNILLCGDPGTSK 516
>pir||S26640 replication licensing factor MCM4 - fission yeast
(Schizosaccharomyces pombe)
Length = 909
Score = 213 bits (538), Expect = 6e-54
Identities = 119/280 (42%), Positives = 179/280 (63%), Gaps = 13/280 (4%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+V+ + G ++ V TA + RD+ T VLE+GALVL+DGG IDE DKM+D
Sbjct: 557 YVHKIAPRGVYTSGKGSSAVGLTAYITRDQDTKQLVLESGALVLSDGGICCIDEFDKMSD 616
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RS++HE +EQQT++++KAGI TLNART+++A+ANP ++N +++ I+LPPTL+
Sbjct: 617 ATRSILHEVMEQQTVTVAKAGIITTLNARTSILASANPIGSKYNPDLPVTKNIDLPPTLL 676
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDL-------LRKYIAYAR 944
SRFDL+++++D DE +D ++A HI+ + + TP+ D+ L YI YAR
Sbjct: 677 SRFDLVYLILDRVDETLDRKLANHIVSMYMED----TPEHATDMEVFSVEFLTSYITYAR 732
Query: 945 KNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLS 1004
N++PVISEEA +E+ YV MRK + E K I T RQLE++IRLSEAHA+M L
Sbjct: 733 NNINPVISEEAAKELVNAYVGMRKLGEDVRASE-KRITATTRQLESMIRLSEAHAKMHLR 791
Query: 1005 PIVTREDAREAIKLMEYTLRQIAVD-ETGQIDVTILEVGQ 1043
+V D EA +L++ ++ A D TG+I + ++ V +
Sbjct: 792 NVVEVGDVLEAARLIKTAIKDYATDPATGKISLDLIYVNE 831
Score = 150 bits (375), Expect = 8e-35
Identities = 116/389 (29%), Positives = 199/389 (50%), Gaps = 62/389 (15%)
Query: 4 EEIIERFLRFLR--------EYAEE------GEEPLYIGKIKDLLAITPKRSIAINWMHL 49
+E I F FLR EY E E+ +YI ++++ I + ++ L
Sbjct: 167 QESIASFRGFLRGFKKKYRPEYRNELMPPPDAEQLVYIEALRNM-RIMGLEILNLDVQDL 225
Query: 50 NSFDP--ELAEEVLENPEECILAAEDAIQIIL--------KEDIMREDVPRIHA-RFYNL 98
+ P +L ++ P+E I + I+ ++ ED++ + +I+ R +NL
Sbjct: 226 KHYPPTKKLYHQLYSYPQEIIPIMDQTIKDVMLDLLGTNPPEDVLNDIELKIYKIRPFNL 285
Query: 99 PKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVA 158
K + ++++ I+KLI ++G+V R T + P + A F C CGH + V+ G +A
Sbjct: 286 EKCINMRDLNPGDIDKLISIKGLVLRCTPVIPDMKQAFFRCSVCGHCVTVEID--RGRIA 343
Query: 159 VK-KC--EKCGSKN-VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDT 214
KC E CG+ N +QL +S+F + Q+ ++Q+ P+ + GQ P + + D++VD+
Sbjct: 344 EPIKCPREVCGATNAMQLIHNRSEFADKQVIKLQETPDVVPDGQTPHSVSLCVYDELVDS 403
Query: 215 AMPGDRVVVVGILRVV--------------------------QEKREKVPTFKKVIEVNY 248
A GDR+ V GI R V Q+KR ++ T +E +
Sbjct: 404 ARAGDRIEVTGIFRCVPVRLNPRMRTVKSLFKTYVDVVHIKKQDKR-RLGTDPSTLESDI 462
Query: 249 IEPVSKEIEEL-EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGG 307
E + +I+E+ +I+ EE +KI++++KR DI D + S+AP+IY +VKKG+ L LFGG
Sbjct: 463 AEDAALQIDEVRKISDEEVEKIQQVSKRDDIYDILSRSLAPSIYEMDDVKKGLLLQLFGG 522
Query: 308 VPRTLPDGT--RLRGDIHVLLVGDPGVAK 334
++ G R RGDI++L+ GDP +K
Sbjct: 523 TNKSFHKGASPRYRGDINILMCGDPSTSK 551
>pir||T38702 hypothetical protein SPAC3F10.01 - fission yeast (Schizosaccharomyces
pombe) (fragment) >gi|1182048|emb|CAA93299.1| (Z69369)
cell division control protein nda4 [Schizosaccharomyces
pombe]
Length = 649
Score = 212 bits (535), Expect = 1e-53
Identities = 116/260 (44%), Positives = 163/260 (62%), Gaps = 6/260 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA++ RD T + LE GA+VLADGG IDE DKM D+DR IHEA+EQQTIS++KAGI
Sbjct: 335 TASIQRDSVTREFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGI 394
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T LN+RT+V+AAANP GR++ MK E I+ T++SRFD+IF++ DE DE D IA
Sbjct: 395 TTILNSRTSVLAAANPIFGRYDDMKTPGENIDFQSTILSRFDMIFIVKDEHDETKDRNIA 454
Query: 914 RHILRVRRGESE----VVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKS 969
RH++ + E + +IP D R+YI Y R P + EA E++ +V +RK
Sbjct: 455 RHVINLHTNLQESSETLAIGEIPFDKFRRYINYCRHKCAPNLDAEAAEKLSSQFVAIRKR 514
Query: 970 VKKSSEE--EIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIA 1027
V +S ++ IPIT RQLEA+IR++E+ A+M LSPI + A EAI+L + A
Sbjct: 515 VHQSEQDSNSRSTIPITVRQLEAIIRITESLAKMSLSPIASEAHATEAIRLFLTSTLAAA 574
Query: 1028 VDETGQIDVTILEVGQSARK 1047
+ ++ + ++ S RK
Sbjct: 575 TQSSPEVTEEVKKIEASLRK 594
Score = 138 bits (344), Expect = 3e-31
Identities = 91/309 (29%), Positives = 156/309 (50%), Gaps = 28/309 (9%)
Query: 51 SFDPELAEEVLENPEECILAAEDAIQIILKEDIMRE------DVPRIHARFYNLPKTLMV 104
S++ +LA +L P + + E A+ + K + R ++P L +
Sbjct: 2 SYNEDLAHLLLSQPTDILPLFESAVTTVAKRLLYRSQENASTNIPTCQVTLRYDANILPI 61
Query: 105 KEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQ-QKPYEGFVAVKKCE 163
+ + A HI+KL++V G++ + + ++ VC++C ++Q + G + CE
Sbjct: 62 RNLTASHISKLVRVPGIIIGASTLSCRATALHLVCRNCRATRILQISGGFSGVQLPRVCE 121
Query: 164 K---------CGSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDD--IV 212
C +D KS F++ Q+ ++Q+ P+ + G++PR I +L D +
Sbjct: 122 APVLDGEKKDCPMDPFIIDHSKSTFIDQQVLKLQEAPDMVPVGELPRHI--LLNADRYLT 179
Query: 213 DTAMPGDRVVVVGILRVVQEKREKVPTFKKVIEVNYIEPVSKEIEELE-------ITPEE 265
+ PG R V+ GI + Q K K + I YI V +++ + + EE
Sbjct: 180 NQITPGTRCVITGIFSIFQNKSVKA-SGAVAIRNPYIRVVGIQMDSNDGSKSTPLFSEEE 238
Query: 266 EQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVL 325
E++ E+++ ++ D I +SI+PAIYG ++KK IA LF G + LPDG RLRGDI+VL
Sbjct: 239 EEEFLEISRTPNLYDIISNSISPAIYGNVDIKKAIACLLFSGSKKILPDGMRLRGDINVL 298
Query: 326 LVGDPGVAK 334
L+GDPG AK
Sbjct: 299 LLGDPGTAK 307
>sp|P41389|NDA4_SCHPO CELL DIVISION CONTROL PROTEIN NDA4
Length = 720
Score = 212 bits (534), Expect = 2e-53
Identities = 116/260 (44%), Positives = 163/260 (62%), Gaps = 6/260 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA++ RD T + LE GA+VLADGG IDE DKM D+DR IHEA+EQQTIS++KAGI
Sbjct: 406 TASIQRDSVTREFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGI 465
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T LN+RT+V+AAANP GR++ MK E I+ T++SRFD+IF++ DE DE D IA
Sbjct: 466 TTILNSRTSVLAAANPIFGRYDDMKTPGENIDFQSTILSRFDMIFIVKDEHDETKDRNIA 525
Query: 914 RHILRVRRGESE----VVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKS 969
RH++ + E + +IP D R+YI Y R P + EA E++ +V +RK
Sbjct: 526 RHVINLHTNLQESSETLAIGEIPFDKFRRYINYCRHKCAPNLDAEAAEKLSSQFVAIRKL 585
Query: 970 VKKSSEE--EIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIA 1027
V +S ++ IPIT RQLEA+IR++E+ A+M LSPI + A EAI+L + A
Sbjct: 586 VHQSEQDSNSRSTIPITVRQLEAIIRITESLAKMSLSPIASEAHATEAIRLFLTSTLAAA 645
Query: 1028 VDETGQIDVTILEVGQSARK 1047
+ ++ + ++ S RK
Sbjct: 646 TQSSPEVTEEVKKIEASLRK 665
Score = 148 bits (371), Expect = 2e-34
Identities = 100/352 (28%), Positives = 180/352 (50%), Gaps = 30/352 (8%)
Query: 8 ERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEEC 67
+ F++F+ E+ + + +Y +++D L + + + I+ HL S++ +LA +L P +
Sbjct: 32 KNFIQFIEEFVIDNDF-IYRTQLRDNLVVK-QYMLNIDLRHLISYNEDLAHLLLSQPTDI 89
Query: 68 ILAAEDAIQIILKEDIMRE------DVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGV 121
+ E A+ + K + R ++P L ++ + A HI+KL++V G+
Sbjct: 90 LPLFESAVTTVAKRLLYRSQENASTNIPTCQVTLRYDANILPIRNLTASHISKLVRVPGI 149
Query: 122 VTRVTEIKPFVSSAVFVCKDCGHEMVVQ-QKPYEGFVAVKKCEK---------CGSKNVQ 171
+ + + ++ VC++C ++Q + G + CE C
Sbjct: 150 IIGASTLSCRATALHLVCRNCRATRILQISGGFSGVQLPRVCEAPVLDGEKKDCPMDPFI 209
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDD--IVDTAMPGDRVVVVGILRV 229
+D KS F++ Q+ ++Q+ P+ + G++PR I +L D + + PG R V+ GI +
Sbjct: 210 IDHSKSTFIDQQVLKLQEAPDMVPVGELPRHI--LLNADRYLTNQITPGTRCVITGIFSI 267
Query: 230 VQEKREKVPTFKKVIEVNYIEPVSKEIEELE-------ITPEEEQKIRELAKRKDIVDAI 282
Q K K + I YI V +++ + + EEE++ E+++ ++ D I
Sbjct: 268 FQNKSVKA-SGAVAIRNPYIRVVGIQMDSNDGSKSTPLFSEEEEEEFLEISRTPNLYDII 326
Query: 283 VDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+SI+PAIYG ++KK IA LF G + LPDG RLRGDI+VLL+GDPG AK
Sbjct: 327 SNSISPAIYGNVDIKKAIACLLFSGSKKILPDGMRLRGDINVLLLGDPGTAK 378
>pir||A48723 replication licensing factor MCM5 - fission yeast
(Schizosaccharomyces pombe) >gi|545211|gb|AAC60568.1|
(S68467) CDC46 homolog=nda4+ [Schizosaccharomyces pombe,
nda4-108, Peptide, 720 aa]
Length = 720
Score = 211 bits (532), Expect = 3e-53
Identities = 116/260 (44%), Positives = 162/260 (61%), Gaps = 6/260 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA++ RD T + LE GA+VLADGG IDE DKM D+DR IHEA+EQQTIS+ KAGI
Sbjct: 406 TASIQRDSVTREFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHEAMEQQTISIRKAGI 465
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T LN+RT+V+AAANP GR++ MK E I+ T++SRFD+IF++ DE DE D IA
Sbjct: 466 TTILNSRTSVLAAANPIFGRYDDMKTPGENIDFQSTILSRFDMIFIVKDEHDETKDRNIA 525
Query: 914 RHILRVRRGESE----VVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKS 969
RH++ + E + +IP D R+YI Y R P + EA E++ +V +RK
Sbjct: 526 RHVINLHTNLQESSETLAIGEIPFDKFRRYINYCRHKCAPNLDAEAAEKLSSQFVAIRKL 585
Query: 970 VKKSSEE--EIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIA 1027
V +S ++ IPIT RQLEA+IR++E+ A+M LSPI + A EAI+L + A
Sbjct: 586 VHQSEQDSNSRSTIPITVRQLEAIIRITESLAKMSLSPIASEAHATEAIRLFLTSTLAAA 645
Query: 1028 VDETGQIDVTILEVGQSARK 1047
+ ++ + ++ S RK
Sbjct: 646 TQSSPEVTEEVKKIEASLRK 665
Score = 148 bits (371), Expect = 2e-34
Identities = 100/352 (28%), Positives = 180/352 (50%), Gaps = 30/352 (8%)
Query: 8 ERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEEC 67
+ F++F+ E+ + + +Y +++D L + + + I+ HL S++ +LA +L P +
Sbjct: 32 KNFIQFIEEFVIDNDF-IYRTQLRDNLVVK-QYMLNIDLRHLISYNEDLAHLLLSQPTDI 89
Query: 68 ILAAEDAIQIILKEDIMRE------DVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGV 121
+ E A+ + K + R ++P L ++ + A HI+KL++V G+
Sbjct: 90 LPLFESAVTTVAKRLLYRSQENASTNIPTCQVTLRYDANILPIRNLTASHISKLVRVPGI 149
Query: 122 VTRVTEIKPFVSSAVFVCKDCGHEMVVQ-QKPYEGFVAVKKCEK---------CGSKNVQ 171
+ + + ++ VC++C ++Q + G + CE C
Sbjct: 150 IIGASTLSCRATALHLVCRNCRATRILQISGGFSGVQLPRVCEAPVLDGEKKDCPMDPFI 209
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDD--IVDTAMPGDRVVVVGILRV 229
+D KS F++ Q+ ++Q+ P+ + G++PR I +L D + + PG R V+ GI +
Sbjct: 210 IDHSKSTFIDQQVLKLQEAPDMVPVGELPRHI--LLNADRYLTNQITPGTRCVITGIFSI 267
Query: 230 VQEKREKVPTFKKVIEVNYIEPVSKEIEELE-------ITPEEEQKIRELAKRKDIVDAI 282
Q K K + I YI V +++ + + EEE++ E+++ ++ D I
Sbjct: 268 FQNKSVKA-SGAVAIRNPYIRVVGIQMDSNDGSKSTPLFSEEEEEEFLEISRTPNLYDII 326
Query: 283 VDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+SI+PAIYG ++KK IA LF G + LPDG RLRGDI+VLL+GDPG AK
Sbjct: 327 SNSISPAIYGNVDIKKAIACLLFSGSKKILPDGMRLRGDINVLLLGDPGTAK 378
>sp|Q57809|Y363_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ0363 >gi|2127803|pir||C64345
replication licensing factor MCM-type homolog MJ0363 -
Methanococcus jannaschii >gi|1591071|gb|AAB98345.1|
(U67489) cell division control protein 21 (cdc21)
[Methanococcus jannaschii]
Length = 759
Score = 209 bits (526), Expect = 2e-52
Identities = 136/332 (40%), Positives = 205/332 (60%), Gaps = 25/332 (7%)
Query: 796 AVVRD--EFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAG- 852
+VVR+ EF WVL+AG L ADGG IDE + N + + +EQQ I ++KAG
Sbjct: 433 SVVREKAEFGDSWVLKAGVLTEADGGVVCIDEFSR-NKEVYDYLLGVMEQQKIEINKAGV 491
Query: 853 ITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEI 912
I A L AR ++AA NP+ GRFN + EQINLP L+ RFDLIFV+ D+ D+K D +I
Sbjct: 492 IDAVLPARVAILAACNPRFGRFNPDLTVWEQINLPKELLDRFDLIFVIKDKIDKKKDEDI 551
Query: 913 A-------RHILRVRRGESE-----VVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIE 960
A +R R+G+S + ++ +LL KY+ YAR+ + P IS+EA + I+
Sbjct: 552 ADFSIDNYNSKVRERKGKSSGKKFVINGVELNDELLLKYVLYARQ-IEPEISDEARKIIK 610
Query: 961 KYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME 1020
+YYV SV+K SE + I+ARQL ++IRL+ AHA++RLS +V DA EAI+L++
Sbjct: 611 EYYV----SVRKMSEAK-GTFGISARQLGSIIRLAVAHAKLRLSEVVKAVDAEEAIRLVD 665
Query: 1021 YTLRQIAVD-ETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKG-AKIDDILEEA 1078
L+QIA D E+G ID+ + G K KVE++L+II+++ + + G A ++I E A
Sbjct: 666 TCLKQIAYDPESGSIDIDKI-AGTPKSKRDKVEKVLNIIKEISNSRDDGLAPEEEIYERA 724
Query: 1079 KKFGIEKQEAREILEKLLEQGQIYMPENGYYR 1110
++ G+ ++E + + L G IY P++GY++
Sbjct: 725 ERAGLSEKEVEDAINYLKRVGDIYSPKSGYWQ 756
>sp|Q58371|Y961_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ0961 >gi|2127860|pir||A64420
replication licensing factor MCM-type homolog MJ0961 -
Methanococcus jannaschii >gi|1591625|gb|AAB98963.1|
(U67539) cell division control protein 54 (cdc54)
[Methanococcus jannaschii]
Length = 762
Score = 208 bits (524), Expect = 3e-52
Identities = 184/609 (30%), Positives = 296/609 (48%), Gaps = 65/609 (10%)
Query: 555 EIEYDDGISYSPAFEKVASLNGGKVKMLPVRRVW-KLRSPGKMIKIRSESGKQITVTPET 613
EIE DD S + + S K K+L ++VW KL GK+ +
Sbjct: 162 EIEIDDYFSEGEFIKDMLSPREVK-KILENKKVWDKLVEKGKIPRCVDLKENDEVFKENL 220
Query: 614 KLLTIIDGSLE--WVEARKLKKGNYVAVV-NKERSIVPIGDFLAKLLKFYGVELNLNEAV 670
K + I + +V ++++ + ++ N E I FL Y +N+ V
Sbjct: 221 KEIKFILDEYDSIYVNIQEMEIQQPIDLMKNPEEPARSIRVFLENTPGIYAGRVNVIGRV 280
Query: 671 ERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLVEMLSSMEGELKEEVMLL 730
+ + R + K S+ I+I E + D +R +L+E L+ + K+ ++ +
Sbjct: 281 MKREYRHNIPIYKIYIKSNY-IKISESYNKIEVKDILRNEELIETLNELGR--KKNIIDI 337
Query: 731 LSDVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEG---------- 780
LS+ E +K+ + + +++ + + + RD H+ +T G
Sbjct: 338 LSNYLISQIKGYELVKKAIFLQQIKGAFKFLPDGTPLRRDSHILLITDPGIGKSTMLRRI 397
Query: 781 SHSFIANGFVVHNTA------AVVRDEFT---GGWVLEAGALVLADGGYALIDELDKMND 831
+ F N + TA A+V E T GWV++ G V A+ G A IDEL ++
Sbjct: 398 ARLFPQNAYASVTTATGGGLTAIVTREATEIGDGWVVKPGVFVRANEGTACIDELT-VDK 456
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
I EA+E QTI ++K GI L AR V+AA NPK+GRF+R + EQI++P L+
Sbjct: 457 NVMKYILEAMESQTIHVNKGGINVKLPARCAVLAACNPKRGRFDRNLTVIEQIDIPAPLL 516
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRVR----------RGESEVVTPKIPHDLLRKYIA 941
SRFDLIF L+D+P+ K D EIA HIL G ++ + LL+ YI
Sbjct: 517 SRFDLIFPLMDKPNRKSDEEIAEHILNTHIETATKDYKILGAIDIDGITVDEKLLKYYII 576
Query: 942 YAR-------------------KNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIP 982
YAR K + P ++++A + I+KYY++MRK E PIP
Sbjct: 577 YARSCAYIEENQDLYLGEFDETKLIMPYLTDKAKKMIKKYYLEMRK-----LGEGDNPIP 631
Query: 983 ITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD-ETGQIDVTILEV 1041
ITARQLEA+IR++E HA+ RLS V DA AI +++ L+Q+A D ETG +D+ +
Sbjct: 632 ITARQLEAIIRIAEMHAKARLSDKVEDVDAEVAISIIDDCLKQVAYDPETGTLDLDKI-A 690
Query: 1042 GQSARKLSKVERILDIIEKLEGTSEKG-AKIDDILEEAKKFGIEKQEAREILEKLLEQGQ 1100
G + K++ +L+II ++ + G A ++I E+A G+ +++ + LE L + G
Sbjct: 691 GTPKSRRDKMDAVLNIIREIVSLRDDGLAPEEEIYEKAMAIGLSEKDVNDALEYLKKAGD 750
Query: 1101 IYMPENGYY 1109
IY P G++
Sbjct: 751 IYNPRYGFW 759
Score = 92.4 bits (226), Expect = 2e-17
Identities = 102/395 (25%), Positives = 171/395 (42%), Gaps = 85/395 (21%)
Query: 17 YAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL------- 69
+ EE Y KIK + K ++ N + N F+ ++ + ++ P+ C +
Sbjct: 4 FDEEVFRAYYEHKIKSFI----KEELSNNLIKGNIFEFDIEKFLMHFPDACEVNDLIIER 59
Query: 70 --AAEDAIQIILKE---DIMRED--VPRIHARFYNLPKTL--MVKEIGAEHINKLIQVEG 120
E+ I I KE ++ ED + +I F N PK +++EI AE INKL++ EG
Sbjct: 60 PKEIEEIILDIFKEAYVELFGEDKELEKIQIAFKN-PKGCEKLIEEISAEDINKLVKFEG 118
Query: 121 VVTRVTEIKPFVSSAV-------------FVCK----DCGHEMVVQ-------------- 149
+ + ++ + AV F+CK C + ++
Sbjct: 119 NILQAGKVNALLKKAVYYCNKRIKDENGGFLCKYTYTPCDGRVEIEIDDYFSEGEFIKDM 178
Query: 150 ------------QKPYEGFVAVKKCEKC------------GSKNVQ--LDVEKSKFVNFQ 183
+K ++ V K +C K ++ LD S +VN Q
Sbjct: 179 LSPREVKKILENKKVWDKLVEKGKIPRCVDLKENDEVFKENLKEIKFILDEYDSIYVNIQ 238
Query: 184 MFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTFKKV 243
IQ + +K + P + L++ + RV V+G + + +E R +P +K
Sbjct: 239 EMEIQQPIDLMKNPEEPARSIRVFLENT--PGIYAGRVNVIGRV-MKREYRHNIPIYKIY 295
Query: 244 IEVNYIEPVSK--EIEELEITPEEE--QKIRELAKRKDIVDAIVDSIAPAIYGYREVKKG 299
I+ NYI+ +IE +I EE + + EL ++K+I+D + + + I GY VKK
Sbjct: 296 IKSNYIKISESYNKIEVKDILRNEELIETLNELGRKKNIIDILSNYLISQIKGYELVKKA 355
Query: 300 IALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
I L G + LPDGT LR D H+LL+ DPG+ K
Sbjct: 356 IFLQQIKGAFKFLPDGTPLRRDSHILLITDPGIGK 390
>emb|CAB55276.1| (AL035461) dJ967N21.5 (novel MCM2/3/5 family member) [Homo sapiens]
Length = 606
Score = 207 bits (521), Expect = 6e-52
Identities = 121/346 (34%), Positives = 192/346 (54%), Gaps = 44/346 (12%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
T + +D +G + LEAGALVL D G IDE DKM ++ ++++ EA+EQQ+ISL+KAG+
Sbjct: 254 TVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGV 312
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L ART++IAAANP G +N+ K +SE + + L+SRFDL+F+L+D P+E D ++
Sbjct: 313 VCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLS 372
Query: 914 RHILRVRRGES---------------------EVVTPK----------------IPHDLL 936
H++ +R G+ EVV+ K IPH LL
Sbjct: 373 EHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLL 432
Query: 937 RKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSE 996
RKYI YAR+ V+P +S EA ++ +Y+++RK + + PIT RQLE+LIRL+E
Sbjct: 433 RKYIGYARQYVYPRLSTEAARVLQDFYLELRK-----QSQRLNSSPITTRQLESLIRLTE 487
Query: 997 AHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSARKLSKVERILD 1056
A AR+ L T+EDA + +++M+Y++ DE G +D + G S +R +
Sbjct: 488 ARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFIS 547
Query: 1057 IIEKL-EGTSEKGAKIDDILEEAKKFGIEKQEAREILEKLLEQGQI 1101
+ + E T + + + AK+ I+ + + L +QG +
Sbjct: 548 ALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYL 593
Score = 74.9 bits (181), Expect = 4e-12
Identities = 46/149 (30%), Positives = 75/149 (49%), Gaps = 7/149 (4%)
Query: 87 DVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM 146
+VP IHAR YN +K + A + K I + G V RV+ IKP + F+C CG E+
Sbjct: 36 NVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACG-EI 94
Query: 147 VVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSK----FVNFQMFRIQD--RPETLKGGQMP 200
P + KC + +S +++Q +IQ+ + + G++P
Sbjct: 95 QSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIP 154
Query: 201 RFIDGILLDDIVDTAMPGDRVVVVGILRV 229
R I+ L+ D+VD+ +PGD V + GI++V
Sbjct: 155 RTIECELVHDLVDSCVPGDTVTITGIVKV 183
>dbj|BAA09949.1| (D63920) xCDC46 [Xenopus laevis]
Length = 716
Score = 205 bits (516), Expect = 2e-51
Identities = 118/316 (37%), Positives = 192/316 (60%), Gaps = 17/316 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 397 TASVMRDPVSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 456
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K E I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 457 TTTLNSRCSVLAAANSVYGRWDDTKG-EENIDFMPTILSRFDMIFIVKDEHNEQRDMTLA 515
Query: 914 RHILRVR---RGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
+H++ V R +S V ++ + L+KYIAY R P +S EA E+++ Y+ MR
Sbjct: 516 KHVMNVHLSARTQSSSVEGEVDLNTLKKYIAYCRAKCGPRLSAEAAEKLKNRYILMRSGA 575
Query: 971 KKSSEEEIK--PIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
++ E K IPIT RQLEA++R+SE+ +M+L P T D EA++L + + A+
Sbjct: 576 REHERETEKRSSIPITVRQLEAIVRISESLGKMKLQPFATETDVEEALRLFQVSTLDAAM 635
Query: 1029 DETGQID-VTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEK 1085
+G + V + LS++E+ +++ G+++ + I+++ K +
Sbjct: 636 --SGSLSGVEGFTTQEDQEMLSRIEK------QMKKRFAIGSQVSEHSIIQDFLKQKYPE 687
Query: 1086 QEAREILEKLLEQGQI 1101
++L ++ +G+I
Sbjct: 688 HAIHKVLSLMMRRGEI 703
Score = 155 bits (387), Expect = 3e-36
Identities = 102/364 (28%), Positives = 180/364 (49%), Gaps = 36/364 (9%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ +RF FLR+Y + + K +D L KR I + L SFD +
Sbjct: 10 KSQLKKRFREFLRQYRIGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDED 65
Query: 56 LAEEVLENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAE 110
LA+ + + P E + E+A Q + E E + I + ++ + +E
Sbjct: 66 LADYLYKQPTEHLQLLEEAAQEVADEVTRPRPAGEETIQEIQVMLRSDANPANIRSLKSE 125
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--EKCG 166
++ L+++ G++ T ++ + C+ C + + + + EG+ +KC E+ G
Sbjct: 126 QMSHLVKIPGIIIAATAVRAKATKISIQCRSCRNTIGNIAVRPGLEGYAMPRKCNTEQAG 185
Query: 167 SKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRV 221
N LD +K K V+FQ ++Q+ P+ + G++PR + + D +PG+RV
Sbjct: 186 RPNCPLDPYFIIPDKCKCVDFQTLKLQESPDAVPHGELPRHMQLYCDRYLCDKVVPGNRV 245
Query: 222 VVVGILRVVQEKREKVPTFKKV---IEVNYIEPVSKEIEEL--------EITPEEEQKIR 270
++GI + + + +V I +YI V +++ ITP+EE++ R
Sbjct: 246 TIMGIYSIRKSGKTSTKGRDRVGVGIRSSYIRVVGIQVDTEGTGRSAAGAITPQEEEEFR 305
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
LA + DI + + SIAP+IYG ++KK IA LFGG + LPDG RGD+++L++GDP
Sbjct: 306 RLAAKPDIYETVAKSIAPSIYGSSDIKKAIACLLFGGSRKRLPDGLTRRGDVNLLMLGDP 365
Query: 331 GVAK 334
G AK
Sbjct: 366 GTAK 369
>sp|P55862|MCM5_XENLA DNA REPLICATION LICENSING FACTOR MCM5 (CDC46 HOMOLOG) (X.CDC46)
>gi|11380985|pir||PC4225 replication licensing factor
MCM5 [validated] - African clawed frog
>gi|2231171|gb|AAC60224.1| (U44048) MCM5/CDC46p [Xenopus
laevis]
Length = 735
Score = 205 bits (516), Expect = 2e-51
Identities = 118/316 (37%), Positives = 192/316 (60%), Gaps = 17/316 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 416 TASVMRDPVSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 475
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K E I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 476 TTTLNSRCSVLAAANSVYGRWDDTKG-EENIDFMPTILSRFDMIFIVKDEHNEQRDMTLA 534
Query: 914 RHILRVR---RGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
+H++ V R +S V ++ + L+KYIAY R P +S EA E+++ Y+ MR
Sbjct: 535 KHVMNVHLSARTQSSSVEGEVDLNTLKKYIAYCRAKCGPRLSAEAAEKLKNRYILMRSGA 594
Query: 971 KKSSEEEIK--PIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
++ E K IPIT RQLEA++R+SE+ +M+L P T D EA++L + + A+
Sbjct: 595 REHERETEKRSSIPITVRQLEAIVRISESLGKMKLQPFATETDVEEALRLFQVSTLDAAM 654
Query: 1029 DETGQID-VTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEK 1085
+G + V + LS++E+ +++ G+++ + I+++ K +
Sbjct: 655 --SGSLSGVEGFTTQEDQEMLSRIEK------QMKKRFAIGSQVSEHSIIQDFLKQKYPE 706
Query: 1086 QEAREILEKLLEQGQI 1101
++L ++ +G+I
Sbjct: 707 HAIHKVLSLMMRRGEI 722
Score = 155 bits (387), Expect = 3e-36
Identities = 102/364 (28%), Positives = 180/364 (49%), Gaps = 36/364 (9%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ +RF FLR+Y + + K +D L KR I + L SFD +
Sbjct: 29 KSQLKKRFREFLRQYRIGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDED 84
Query: 56 LAEEVLENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAE 110
LA+ + + P E + E+A Q + E E + I + ++ + +E
Sbjct: 85 LADYLYKQPTEHLQLLEEAAQEVADEVTRPRPAGEETIQEIQVMLRSDANPANIRSLKSE 144
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--EKCG 166
++ L+++ G++ T ++ + C+ C + + + + EG+ +KC E+ G
Sbjct: 145 QMSHLVKIPGIIIAATAVRAKATKISIQCRSCRNTIGNIAVRPGLEGYAMPRKCNTEQAG 204
Query: 167 SKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRV 221
N LD +K K V+FQ ++Q+ P+ + G++PR + + D +PG+RV
Sbjct: 205 RPNCPLDPYFIIPDKCKCVDFQTLKLQESPDAVPHGELPRHMQLYCDRYLCDKVVPGNRV 264
Query: 222 VVVGILRVVQEKREKVPTFKKV---IEVNYIEPVSKEIEEL--------EITPEEEQKIR 270
++GI + + + +V I +YI V +++ ITP+EE++ R
Sbjct: 265 TIMGIYSIRKSGKTSTKGRDRVGVGIRSSYIRVVGIQVDTEGTGRSAAGAITPQEEEEFR 324
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
LA + DI + + SIAP+IYG ++KK IA LFGG + LPDG RGD+++L++GDP
Sbjct: 325 RLAAKPDIYETVAKSIAPSIYGSSDIKKAIACLLFGGSRKRLPDGLTRRGDVNLLMLGDP 384
Query: 331 GVAK 334
G AK
Sbjct: 385 GTAK 388
>emb|CAA73947.1| (Y13624) minichromosome maintenance like protein [Saccharomyces
cerevisiae]
Length = 562
Score = 199 bits (502), Expect = 1e-49
Identities = 137/370 (37%), Positives = 207/370 (55%), Gaps = 23/370 (6%)
Query: 665 NLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLVEMLS-SMEGEL 723
N+ + ERDQ L +L S +++ L+ +K + + Y LV ++ ++ G
Sbjct: 37 NVYQDNERDQ-EVFLNSLSSDEINE--------LKEMVKDEHI-YDKLVRSIAPAVFGHE 86
Query: 724 KEEVMLLLSDVGDIHEVIQERLKEIGKI---LESDASWERIAEVEEVVRDGHVYDLTVEG 780
+ +LL +G +H+ E +K G I + D S + ++ VV G
Sbjct: 87 AVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVV--GFAPRSVYTS 144
Query: 781 SHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEA 840
+ A G TAAVVRDE G + +EAGAL+LAD G IDE DKM+ D+ IHEA
Sbjct: 145 GKASSAAGL----TAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEA 200
Query: 841 LEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVL 900
+EQQTIS++KAGI ATLNART+++AAANP GR+NR + +N+ +MSRFDL FV+
Sbjct: 201 MEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVI 260
Query: 901 VDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIE 960
+D+ +EKID+E+A HI+ + E + P + LR+YI YAR P++++EA +
Sbjct: 261 LDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYAR-TFKPILTKEARSYLV 319
Query: 961 KYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME 1020
+ Y ++RK + IT RQLE++IRLSEA AR +T EA L+
Sbjct: 320 EKYKELRKDDAQGFSR--SSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLR 377
Query: 1021 YTLRQIAVDE 1030
++ ++ VD+
Sbjct: 378 QSIIRVDVDD 387
Score = 73.7 bits (178), Expect = 1e-11
Identities = 32/74 (43%), Positives = 53/74 (71%)
Query: 261 ITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRG 320
++ +E +++E+ K + I D +V SIAPA++G+ VKKGI L + GGV ++ +G +LRG
Sbjct: 53 LSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRG 112
Query: 321 DIHVLLVGDPGVAK 334
DI++ +VGDP +K
Sbjct: 113 DINICVVGDPSTSK 126
>gi|6321237 component of MCM initiator complex involved in DNA replication; Mcm6p
[Saccharomyces cerevisiae]
>gi|1723953|sp|P53091|MCM6_YEAST MINICHROMOSOME
MAINTENANCE PROTEIN 6 >gi|2131619|pir||S64219 replication
licensing factor MCM6 - yeast (Saccharomyces cerevisiae)
>gi|1322832|emb|CAA96913.1| (Z72723) ORF YGL201c
[Saccharomyces cerevisiae]
Length = 1017
Score = 199 bits (502), Expect = 1e-49
Identities = 137/370 (37%), Positives = 207/370 (55%), Gaps = 23/370 (6%)
Query: 665 NLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLVEMLS-SMEGEL 723
N+ + ERDQ L +L S +++ L+ +K + + Y LV ++ ++ G
Sbjct: 492 NVYQDNERDQ-EVFLNSLSSDEINE--------LKEMVKDEHI-YDKLVRSIAPAVFGHE 541
Query: 724 KEEVMLLLSDVGDIHEVIQERLKEIGKI---LESDASWERIAEVEEVVRDGHVYDLTVEG 780
+ +LL +G +H+ E +K G I + D S + ++ VV G
Sbjct: 542 AVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVV--GFAPRSVYTS 599
Query: 781 SHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEA 840
+ A G TAAVVRDE G + +EAGAL+LAD G IDE DKM+ D+ IHEA
Sbjct: 600 GKASSAAGL----TAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEA 655
Query: 841 LEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVL 900
+EQQTIS++KAGI ATLNART+++AAANP GR+NR + +N+ +MSRFDL FV+
Sbjct: 656 MEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVI 715
Query: 901 VDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIE 960
+D+ +EKID+E+A HI+ + E + P + LR+YI YAR P++++EA +
Sbjct: 716 LDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYAR-TFKPILTKEARSYLV 774
Query: 961 KYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME 1020
+ Y ++RK + IT RQLE++IRLSEA AR +T EA L+
Sbjct: 775 EKYKELRKDDAQGFSR--SSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLR 832
Query: 1021 YTLRQIAVDE 1030
++ ++ VD+
Sbjct: 833 QSIIRVDVDD 842
Score = 78.4 bits (190), Expect = 4e-13
Identities = 49/142 (34%), Positives = 73/142 (50%), Gaps = 6/142 (4%)
Query: 95 FYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGH--EMVVQQKP 152
F+NLP +++I +E I L+ + G VTR +E++P + A F C C + V Q
Sbjct: 267 FFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFK 326
Query: 153 YEG--FVAVKKCEKCGSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDD 210
Y F CE L+V +S+F+++Q RIQ+ + G MPR +D IL D
Sbjct: 327 YTEPTFCPNPSCENRAFWT--LNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGD 384
Query: 211 IVDTAMPGDRVVVVGILRVVQE 232
V+ A PGDR G+ VV +
Sbjct: 385 SVERAKPGDRCKFTGVEIVVPD 406
Score = 73.7 bits (178), Expect = 1e-11
Identities = 32/74 (43%), Positives = 53/74 (71%)
Query: 261 ITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRG 320
++ +E +++E+ K + I D +V SIAPA++G+ VKKGI L + GGV ++ +G +LRG
Sbjct: 508 LSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRG 567
Query: 321 DIHVLLVGDPGVAK 334
DI++ +VGDP +K
Sbjct: 568 DINICVVGDPSTSK 581
>gi|6678830 mini chromosome maintenance deficient 5 (S. cerevisiae) [Mus
musculus] >gi|1705525|sp|P49718|MCM5_MOUSE DNA
REPLICATION LICENSING FACTOR MCM5 (CDC46 HOMOLOG)
(P1-CDC46) >gi|1363106|pir||S56767 replication licensing
factor MCM5 - mouse >gi|940404|dbj|BAA05083.1| (D26090)
mCDC46 protein [Mus musculus]
Length = 733
Score = 199 bits (501), Expect = 1e-49
Identities = 114/316 (36%), Positives = 194/316 (61%), Gaps = 17/316 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 414 TASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 473
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K + I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 474 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDMMLA 532
Query: 914 RHILRVRRG---ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
+H++ + +++ V +I ++K+IAY R P +S EA E+++ Y+ MR
Sbjct: 533 KHVMTLHVSALTQTQAVEGEIDLAKMKKFIAYCRARCGPRLSAEAAEKLKNRYIIMRSGA 592
Query: 971 KKSSEEEIK--PIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
++ + + IPIT RQLEA++R++EA ++M+L P T D EA++L + + A+
Sbjct: 593 RQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL 652
Query: 1029 DETGQID-VTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEK 1085
+G + V + LS++E+ +L+ G+++ + I+++ K +
Sbjct: 653 --SGNLSGVEGFTTQEDQEMLSRIEK------QLKRRFAIGSQVSEHSIVQDFTKQKYPE 704
Query: 1086 QEAREILEKLLEQGQI 1101
R++L+ +L +G+I
Sbjct: 705 HAIRKVLQLMLRRGEI 720
Score = 129 bits (322), Expect = 1e-28
Identities = 96/367 (26%), Positives = 183/367 (49%), Gaps = 43/367 (11%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ RF FLR+Y + + K +D L KR I + L SFD E
Sbjct: 28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDEE 83
Query: 56 LAEEVLENPEECILAAEDAIQIILKE--------DIMREDVPRIHARFYNLPKTLMVKEI 107
LA+ + + P E + E+A + + E D + +D+ ++ + P ++ + +
Sbjct: 84 LADHLHKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDI-QVMLKSDASPSSIRI--L 140
Query: 108 GAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--E 163
++ ++ L+++ G++ + ++ + C+ C + + + +P G +KC +
Sbjct: 141 KSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMPRP-RGLCLPRKCNMD 199
Query: 164 KCGSKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPG 218
+ G LD +K K V+FQ ++Q+ P+ + G+MPR + + D +PG
Sbjct: 200 QAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPG 259
Query: 219 DRVVVVGILRVVQ------EKREKV-----PTFKKVIEVNYIEPVSKEIEELEITPEEEQ 267
+RV ++GI + + + R++V ++ +V+ + S ++P+EE+
Sbjct: 260 NRVTIMGIYSIKKFGLNPSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGSVSPQEEE 319
Query: 268 KIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLV 327
+ R LA +I + I SI+P+I+G ++KK IA LFGG + LPDG RGDI++L++
Sbjct: 320 EFRRLAALPNIYELISKSISPSIFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLML 379
Query: 328 GDPGVAK 334
GDPG AK
Sbjct: 380 GDPGTAK 386
>gb|AAD32857.1|AF124743_1 (AF124743) DNA replication factor MCM7 [Drosophila melanogaster]
>gi|7295030|gb|AAF50357.1| (AE003554) Mcm7 gene product
[Drosophila melanogaster]
Length = 720
Score = 198 bits (497), Expect = 4e-49
Identities = 141/426 (33%), Positives = 224/426 (52%), Gaps = 30/426 (7%)
Query: 674 QARKLLETLKSKGLSDVTIEI-PEKLRRFIKCDRVRYVDLVEMLSSMEGELKEEVMLLLS 732
QA +++ K+ +SD E+ PE+L + D + + + G L + LLL
Sbjct: 299 QAHRIICINKNDEISDKDAELTPEELEELAQDDFYERL-ATSLAPEIYGHLDVKKALLLL 357
Query: 733 DVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEGSHSFIANGFVVH 792
VG + + + +K G I +A+ + + G++ L V ++ V
Sbjct: 358 LVGGVDKR-PDGMKIRGNINICLMGDPGVAKSQLL---GYISRLAVRSQYTTGRGSSGVG 413
Query: 793 NTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAG 852
TAAV++D TG LE GALVLAD G IDE DKM D+DR+ IHE +EQQTIS++KAG
Sbjct: 414 LTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAG 473
Query: 853 ITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEI 912
I TLNAR +++AAANP GR+N + + + I LP L+SRFDL++++ D+PD D +
Sbjct: 474 IMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRL 533
Query: 913 ARHILRVRRGESEVVT--PKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
A+HI V + T + +L+R+YI ++ +P I +E + I YV++R+
Sbjct: 534 AKHITYVHSHSKQPPTRVKALDMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREA 592
Query: 971 KKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEY---TLRQIA 1027
+ + +AR L ++RLS A AR+RLS V ++D EA++L+E +L QI
Sbjct: 593 RNQKDMTF----TSARNLLGILRLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIH 648
Query: 1028 VDETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQE 1087
+ G + T +RI I+ +L G S K KI DI++ G + +
Sbjct: 649 EHQKGHVPNT-------------SDRIFAIVRELAG-SGKAVKISDIMDRCTTKGFKPDQ 694
Query: 1088 AREILE 1093
+ ++
Sbjct: 695 VDKCID 700
Score = 138 bits (344), Expect = 3e-31
Identities = 113/389 (29%), Positives = 180/389 (46%), Gaps = 66/389 (16%)
Query: 2 DREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVL 61
DRE I + FL + ++G++ G LA + I I+ L F+ LAE V+
Sbjct: 9 DRESI-KTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVV 67
Query: 62 ENPEECI------------------LAAEDAIQIILKEDIMREDVPR------------- 90
+N + A+DA+ + ++ +M E R
Sbjct: 68 DNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFP 127
Query: 91 --IHARF------YNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDC 142
+ RF + K ++E+ A+HI KL+ V G+VTR TE+KP + A + C C
Sbjct: 128 SELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRC 187
Query: 143 GHEMVVQQKPYEGFVAVKKC-------EKCGSKNVQLDVEKSKFVNFQMFRIQDRPETLK 195
G E Q F V C K G + + L SKFV FQ ++Q+ + +
Sbjct: 188 GSE-TYQPVNSLSFTPVHDCPSDDCRVNKAGGR-LYLQTRGSKFVKFQEVKMQEHSDQVP 245
Query: 196 GGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEK----------REKVPTFKKVIE 245
G +PR + + ++ A PGD +VV G+ + E ++I
Sbjct: 246 VGHIPRSMTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHRIIC 305
Query: 246 VNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALF 305
+N + +S ++ E+TPEE + ELA + D + + S+AP IYG+ +VKK + L L
Sbjct: 306 INKNDEISD--KDAELTPEE---LEELA-QDDFYERLATSLAPEIYGHLDVKKALLLLLV 359
Query: 306 GGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
GGV + PDG ++RG+I++ L+GDPGVAK
Sbjct: 360 GGVDKR-PDGMKIRGNINICLMGDPGVAK 387
>gb|AAF54557.1| (AE003688) Mcm5 gene product [Drosophila melanogaster]
Length = 733
Score = 197 bits (496), Expect = 5e-49
Identities = 123/319 (38%), Positives = 192/319 (59%), Gaps = 21/319 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V++D T +V+E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 412 TASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 471
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K E I+ PT++SRFD+IF++ D DE D +A
Sbjct: 472 TTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLA 530
Query: 914 RHILRV-----RRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK 968
+HI+ V + SE +I +KYI Y R + P +SE A E+++ YV MR
Sbjct: 531 KHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRS 590
Query: 969 SV---KKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQ 1025
+K+S++ + IPIT RQLEA+IR+SE+ A++RL P T E EA++L + +
Sbjct: 591 GAGQQEKASDKRLS-IPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLD 649
Query: 1026 IAVDETGQIDVTILEVGQSARKLSKVERILDIIEK-LEGTSEKGAKIDD--ILEEAKKFG 1082
A+ TG + G + + L+ IEK L+ G+++ + IL++ +
Sbjct: 650 AAM--TGSL------AGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQK 701
Query: 1083 IEKQEAREILEKLLEQGQI 1101
E++ +++ ++ +G++
Sbjct: 702 YEERTVMKVIHTMIRRGEL 720
Score = 127 bits (317), Expect = 5e-28
Identities = 96/361 (26%), Positives = 175/361 (47%), Gaps = 34/361 (9%)
Query: 4 EEIIERFLRFLREYAEEGEEPLYIGKIKDLLA---ITPKRSIAINWMHLNSFDPELAEEV 60
+ + +++ F+R + EE + K +D L + + + I L FD LA+++
Sbjct: 28 QAVKKKYKEFIRTFNEEN----FFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKL 83
Query: 61 LENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAEHINKL 115
+ P E + E+A + + E E + I + ++++ ++ ++KL
Sbjct: 84 NKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKL 143
Query: 116 IQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMV-VQQKP-YEGFVAVKKC--EKCGSKNVQ 171
+++ G++ + I + C C + ++ P EG+ +KC E+ G
Sbjct: 144 VKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKCNTEQAGRPKCP 203
Query: 172 LDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGI 226
LD +K K V+FQ ++Q+ P+ + G++PR + + + +PG+RV++ GI
Sbjct: 204 LDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGI 263
Query: 227 --LRVVQEKREKVPTFKKVIEVN--YIEPVSKEIEE---------LEITPEEEQKIRELA 273
+R V + + K V+ V Y+ V ++ IT +EE+ R +A
Sbjct: 264 YSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMA 323
Query: 274 KRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVA 333
DI + + S+AP+I+G R++KK I LFGG + LPDG RGDI+VLL+GDPG A
Sbjct: 324 ASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTA 383
Query: 334 K 334
K
Sbjct: 384 K 384
>gb|AAC47652.1| (U83493) MCM5 homolog [Drosophila melanogaster]
Length = 732
Score = 197 bits (495), Expect = 7e-49
Identities = 123/319 (38%), Positives = 192/319 (59%), Gaps = 21/319 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V++D T +V+E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 411 TASVMKDPQTRNFVVEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 470
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K E I+ PT++SRFD+IF++ D DE D +A
Sbjct: 471 TTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLA 529
Query: 914 RHILRV-----RRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK 968
+HI+ V + SE +I +KYI Y R + P +SE A E+++ YV MR
Sbjct: 530 KHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRS 589
Query: 969 SV---KKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQ 1025
+K+S++ + IPIT RQLEA+IR+SE+ A++RL P T E EA++L + +
Sbjct: 590 GAGQQEKASDKRLS-IPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLD 648
Query: 1026 IAVDETGQIDVTILEVGQSARKLSKVERILDIIEK-LEGTSEKGAKIDD--ILEEAKKFG 1082
A+ TG + G + + L+ IEK L+ G+++ + IL++ +
Sbjct: 649 AAM--TGSL------AGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQK 700
Query: 1083 IEKQEAREILEKLLEQGQI 1101
E++ +++ ++ +G++
Sbjct: 701 YEERTVMKVIHTMIRRGEL 719
Score = 121 bits (300), Expect = 5e-26
Identities = 99/362 (27%), Positives = 173/362 (47%), Gaps = 37/362 (10%)
Query: 4 EEIIERFLRFLREYAEEGEEPLYIGKIKDLLA---ITPKRSIAINWMHLNSFDPELAE-- 58
+ + +++ F+R + EE + K +D L + + + I L FD LA+
Sbjct: 28 QAVKKKYKEFIRTFNEEN----FFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADTD 83
Query: 59 ----EVLENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINK 114
E LE EE A E A +I E + I + ++++ ++ ++K
Sbjct: 84 KQPTEHLEIFEEA--AREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSK 141
Query: 115 LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMV-VQQKP-YEGFVAVKKC--EKCGSKNV 170
L+++ G++ + I + C C + ++ P EG+ +KC E+ G
Sbjct: 142 LVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKCNTEQAGRPKC 201
Query: 171 QLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVG 225
LD +K K V+FQ ++Q+ P+ + G++PR + + + +PG+RV++ G
Sbjct: 202 PLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQG 261
Query: 226 I--LRVVQEKREKVPTFKKVIEVN--YIEPVSKEIEE---------LEITPEEEQKIREL 272
I +R V + + K V+ V Y+ V ++ IT +EE+ +R +
Sbjct: 262 IYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGVGAISRYSNITSDEEEHLRRM 321
Query: 273 AKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGV 332
A DI + + S+AP+I+G R++KK I LFG + LPDG RGDI+VLL+GDPG
Sbjct: 322 AASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGVSRKRLPDGLCRRGDINVLLLGDPGT 381
Query: 333 AK 334
AK
Sbjct: 382 AK 383
>gi|11418031 minichromosome maintenance deficient (S. cerevisiae) 5 (cell division
cycle 46) [Homo sapiens] >gi|5824002|emb|CAA52802.2|
(X74795) P1 Cdc46 [Homo sapiens]
Length = 734
Score = 196 bits (494), Expect = 9e-49
Identities = 114/315 (36%), Positives = 191/315 (60%), Gaps = 15/315 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 415 TASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 474
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K + I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 475 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLA 533
Query: 914 RHILRVRRG---ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
+H++ + +++ V +I L+K+IAY R P +S EA E+++ Y+ MR
Sbjct: 534 KHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGA 593
Query: 971 KKSSEEEIK--PIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
++ + + IPIT RQLEA++R++EA ++M+L P T D EA++L + + A+
Sbjct: 594 RQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL 653
Query: 1029 DETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEKQ 1086
T V + LS++E+ +L+ G+++ + I+++ K +
Sbjct: 654 SGT-LSGVEGFTSQEDQEMLSRIEK------QLKRRFAIGSQVSEHSIIKDFTKQKYPEH 706
Query: 1087 EAREILEKLLEQGQI 1101
++L+ +L +G+I
Sbjct: 707 AIHKVLQLMLRRGEI 721
Score = 133 bits (332), Expect = 9e-30
Identities = 94/364 (25%), Positives = 176/364 (47%), Gaps = 36/364 (9%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ RF FLR+Y + + K +D L KR I + L SFD +
Sbjct: 28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDED 83
Query: 56 LAEEVLENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAE 110
LA+ + + P E + E+A + + E E + I + ++ + ++
Sbjct: 84 LADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSD 143
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--EKCG 166
++ L+++ G++ + ++ + C+ C + + + + EG+ +KC ++ G
Sbjct: 144 MMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAG 203
Query: 167 SKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRV 221
LD +K K V+FQ ++Q+ P+ + G+MPR + + D +PG+RV
Sbjct: 204 RPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRV 263
Query: 222 VVVGILRV------VQEKREKV-----PTFKKVIEVNYIEPVSKEIEELEITPEEEQKIR 270
++GI + R++V ++ +V+ + S ++P+EE++ R
Sbjct: 264 TIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFR 323
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
LA ++ + I SIAP+I+G ++KK IA LFGG + LPDG RGDI++L++GDP
Sbjct: 324 RLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDP 383
Query: 331 GVAK 334
G AK
Sbjct: 384 GTAK 387
>sp|P33992|MCM5_HUMAN DNA REPLICATION LICENSING FACTOR MCM5 (CDC46 HOMOLOG) (P1-CDC46)
Length = 734
Score = 196 bits (493), Expect = 1e-48
Identities = 114/315 (36%), Positives = 191/315 (60%), Gaps = 15/315 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 415 TASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 474
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K + I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 475 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLA 533
Query: 914 RHILRVRRG---ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
+H++ + +++ V +I L+K+IAY R P +S EA E+++ Y+ MR
Sbjct: 534 KHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRTGA 593
Query: 971 KKSSEEEIK--PIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
++ + + IPIT RQLEA++R++EA ++M+L P T D EA++L + + A+
Sbjct: 594 RQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL 653
Query: 1029 DETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEKQ 1086
T V + LS++E+ +L+ G+++ + I+++ K +
Sbjct: 654 SGT-LSGVEGFTSQEDQEMLSRIEK------QLKRRFAIGSQVSEHSIIKDFTKQKYPEH 706
Query: 1087 EAREILEKLLEQGQI 1101
++L+ +L +G+I
Sbjct: 707 AIHKVLQLMLRRGEI 721
Score = 133 bits (332), Expect = 9e-30
Identities = 94/364 (25%), Positives = 176/364 (47%), Gaps = 36/364 (9%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ RF FLR+Y + + K +D L KR I + L SFD +
Sbjct: 28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDED 83
Query: 56 LAEEVLENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAE 110
LA+ + + P E + E+A + + E E + I + ++ + ++
Sbjct: 84 LADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSD 143
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--EKCG 166
++ L+++ G++ + ++ + C+ C + + + + EG+ +KC ++ G
Sbjct: 144 MMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAG 203
Query: 167 SKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRV 221
LD +K K V+FQ ++Q+ P+ + G+MPR + + D +PG+RV
Sbjct: 204 RPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRV 263
Query: 222 VVVGILRV------VQEKREKV-----PTFKKVIEVNYIEPVSKEIEELEITPEEEQKIR 270
++GI + R++V ++ +V+ + S ++P+EE++ R
Sbjct: 264 TIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFR 323
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
LA ++ + I SIAP+I+G ++KK IA LFGG + LPDG RGDI++L++GDP
Sbjct: 324 RLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDP 383
Query: 331 GVAK 334
G AK
Sbjct: 384 GTAK 387
>gb|AAF18476.1|AF211951_1 (AF211951) minichromosome maintenance 5 protein [Entamoeba
histolytica]
Length = 527
Score = 195 bits (491), Expect = 2e-48
Identities = 109/239 (45%), Positives = 148/239 (61%), Gaps = 9/239 (3%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV +D TG + L GALVL DGG IDE DKMN+ DR IHEA+EQQTIS++KAGI
Sbjct: 293 TAAVNKDSSTGEFYLNGGALVLGDGGVVCIDEFDKMNEVDRVAIHEAMEQQTISIAKAGI 352
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TA LNAR+ V+AAANP GRFN + +NL T++SRFD+IF++ D+ D K D EI
Sbjct: 353 TAVLNARSAVLAAANPSFGRFNERASFGDNVNLKTTILSRFDMIFMIRDKHDAKRDKEIV 412
Query: 914 RHILRVRRGESEVVTPKIPH--DLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+H +V K+ + ++YIAY + P ++ A ++ Y+V +R+ V+
Sbjct: 413 KHYYGY-----SIVKRKVDNLSQAFKEYIAYCKAYCIPRLTVNASNKLSNYFVSIRQKVR 467
Query: 972 --KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
K + + IPIT RQLEA+IR+SEA A+M +S I EAI+L E + AV
Sbjct: 468 ENKLENDNDEGIPITVRQLEAIIRISEALAKMTMSDIADENHVDEAIRLFELSTMNSAV 526
Score = 117 bits (291), Expect = 6e-25
Identities = 74/246 (30%), Positives = 132/246 (53%), Gaps = 21/246 (8%)
Query: 100 KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAV 159
K + + + + ++K+I+V G++ ++ ++P V+ A+ CK E+ V G +
Sbjct: 30 KMIQPRMLQSSFLSKVIRVSGIIVSISRVEPKVTKAILRCK-LQKEIAVIVPSCCGIINY 88
Query: 160 -KKCE--------KCGSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDD 210
K C+ KC + EK KFV+ + ++Q+ PE + G++PR + I +D
Sbjct: 89 PKSCDGVSPVTGKKCPPDPYDVVTEKCKFVDRIVLKLQETPENVAPGEVPRTVTVIFRND 148
Query: 211 I--VDTAMPGDRVVVVGILRVVQEKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQK 268
I + G R+ + GI ++ K I +YI + EI ++ +++++
Sbjct: 149 ICLLLDLTAGQRIFIEGIFGACLQR-------KGTISTSYIRAIGIEISG-QVVSQDDRR 200
Query: 269 IRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVG 328
++E+A R + ++ SIAPAI GY ++K+ + + GG + LPDGT LRGDI+VLL+G
Sbjct: 201 MKEVA-RTITKEKLIKSIAPAICGYDDIKEAVLCLMLGGSGKALPDGTHLRGDINVLLMG 259
Query: 329 DPGVAK 334
DPG AK
Sbjct: 260 DPGTAK 265
>gi|6323304 MCM initiator complex protein; Cdc46p [Saccharomyces cerevisiae]
>gi|231717|sp|P29496|MCM5_YEAST MINICHROMOSOME
MAINTENANCE PROTEIN 5 (CELL DIVISION CONTROL PROTEIN 46)
>gi|101247|pir||A39631 replication licensing factor MCM5
[validated] - yeast (Saccharomyces cerevisiae)
>gi|485273|gb|AAA18027.1| (U09242) Cdc46p [Saccharomyces
cerevisiae] >gi|577187|gb|AAB67364.1| (U17245) Cdc46p
[Saccharomyces cerevisiae]
Length = 775
Score = 195 bits (490), Expect = 3e-48
Identities = 102/236 (43%), Positives = 151/236 (63%), Gaps = 9/236 (3%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V RD T + LE GA+VLADGG IDE DKM D+DR IHEA+EQQTIS++KAGI
Sbjct: 450 TASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGI 509
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T LN+RT+V+AAANP GR++ +K + I+ T++SRFD+IF++ D+ +E+ D IA
Sbjct: 510 TTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIA 569
Query: 914 RHILRVRRGESEVVT-------PKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKM 966
H++ + G + + +I + +++YI Y R P +S +A E++ +V +
Sbjct: 570 NHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTI 629
Query: 967 RKS--VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME 1020
RK + + E IPIT RQLEA+IR++E+ A++ LSPI EAI+L +
Sbjct: 630 RKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQ 685
Score = 127 bits (315), Expect = 9e-28
Identities = 89/402 (22%), Positives = 176/402 (43%), Gaps = 71/402 (17%)
Query: 2 DREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVL 61
D EII+ F F+ E+ + + +Y ++++ + + S+ +N HL ++ ++ +++
Sbjct: 23 DNTEIIKSFKNFILEFRLDSQF-IYRDQLRNNILVK-NYSLTVNMEHLIGYNEDIYKKLS 80
Query: 62 ENPEECILAAEDAIQIILK-------------------------EDIMREDVPRIHARFY 96
+ P + I E AI + K + ++ +P
Sbjct: 81 DEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQLILN 140
Query: 97 NLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGF 156
+ + ++++ +EH++K++++ G++ + + + +C++C H + +
Sbjct: 141 SNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSI 200
Query: 157 VA-----VKKC----------------------EKCGSKNVQLDVEKSKFVNFQMFRIQD 189
+ C + CG + E SKF++ Q ++Q+
Sbjct: 201 TGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQE 260
Query: 190 RPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKRE-------------- 235
PE + G+MPR + + + +PG RV +VGI + K
Sbjct: 261 IPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSG 320
Query: 236 ---KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYG 292
+ P K + + +E S T EEE++ +L++ + + + +SIAP+I+G
Sbjct: 321 VAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFG 380
Query: 293 YREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
++KK I L GG + LPDG RLRGDI+VLL+GDPG AK
Sbjct: 381 NEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAK 422
>dbj|BAA34733.1| (AB010109) MCM7 [Drosophila melanogaster]
Length = 717
Score = 194 bits (487), Expect = 6e-48
Identities = 135/407 (33%), Positives = 218/407 (53%), Gaps = 16/407 (3%)
Query: 674 QARKLLETLKSKGLSDVTIEI-PEKLRRFIKCDRVRYVDLVEMLSSMEGELKEEVMLLLS 732
QA +++ K+ +SD E+ PE+L + D + + + G L + LLL
Sbjct: 297 QAHRIICINKNDEISDKDAELTPEELEELAQDDFYERL-ATSLAPEIYGHLDVKKALLLL 355
Query: 733 DVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEGSHSFIANGFVVH 792
VG + + + +K G I +A+ + + G++ L V ++ V
Sbjct: 356 LVGGVDKR-PDGMKIRGNINICLMGDPGVAKSQLL---GYISRLAVRSQYTTGRGSSGVG 411
Query: 793 NTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAG 852
TAAV++D TG LE GALVLAD G IDE DKM D+DR+ IHE +EQQTIS++KAG
Sbjct: 412 LTAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAG 471
Query: 853 ITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEI 912
I TLNAR +++AAANP GR+N + + + I LP L+SRFDL++++ D+PD D +
Sbjct: 472 IMTTLNARVSILAAANPAFGRYNPRRTVEQNIELPAALLSRFDLLWLIQDKPDRDNDLRL 531
Query: 913 ARHILRVRRGESEVVT--PKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
A+HI V + T + +L+R+YI ++ +P I +E + I YV++R+
Sbjct: 532 AKHITYVHSHSKQPPTRVKALDMNLMRRYINLCKRK-NPTIPDELTDYIVGAYVELRREA 590
Query: 971 KKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEY---TLRQIA 1027
+ + +AR L ++RLS A A +RLS V ++D EA++L+E +L QI
Sbjct: 591 RNQKDMTF----TSARNLLGILRLSTALAWLRLSDTVEKDDVAEALRLLEMSKDSLNQIH 646
Query: 1028 VDETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDI 1074
+ G + T + R+L+ + + I ++ ++ KG K D +
Sbjct: 647 EHQKGHVPNTTDRIFAIVRELAGSGKAVKISHIIDRSTTKGFKPDQV 693
Score = 134 bits (333), Expect = 7e-30
Identities = 113/389 (29%), Positives = 179/389 (45%), Gaps = 68/389 (17%)
Query: 2 DREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVL 61
DRE I + FL + ++G++ G LA + I I+ L F+ LAE V+
Sbjct: 9 DRESI-KTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVV 67
Query: 62 ENPEECI------------------LAAEDAIQIILKEDIMREDVPR------------- 90
+N + A+DA+ + ++ +M E R
Sbjct: 68 DNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFP 127
Query: 91 --IHARF------YNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDC 142
+ RF + K ++E+ A+HI KL+ V G+VTR TE+KP + A + C C
Sbjct: 128 SELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRC 187
Query: 143 GHEMVVQQKPYEGFVAVKKC-------EKCGSKNVQLDVEKSKFVNFQMFRIQDRPETLK 195
G E Q F V C K G + + L SKFV FQ ++Q+ + +
Sbjct: 188 GSE-TYQPVNSLSFTPVHDCPSDDCRVNKAGGR-LYLQTRGSKFVKFQEVKMQEHSDQVP 245
Query: 196 GGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEK----------REKVPTFKKVIE 245
G +P I + ++ A PGD +VV G+ + E ++I
Sbjct: 246 VGHIPMTI--MCRGEVTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHRIIC 303
Query: 246 VNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALF 305
+N + +S ++ E+TPEE + ELA + D + + S+AP IYG+ +VKK + L L
Sbjct: 304 INKNDEISD--KDAELTPEE---LEELA-QDDFYERLATSLAPEIYGHLDVKKALLLLLV 357
Query: 306 GGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
GGV + PDG ++RG+I++ L+GDPGVAK
Sbjct: 358 GGVDKR-PDGMKIRGNINICLMGDPGVAK 385
>pir||T50339 mis5 protein [imported] - fission yeast (Schizosaccharomyces pombe)
>gi|6983768|emb|CAB75412.1| (AL139314) mis5 protein
[Schizosaccharomyces pombe]
Length = 892
Score = 194 bits (487), Expect = 6e-48
Identities = 106/237 (44%), Positives = 152/237 (63%), Gaps = 3/237 (1%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVV+DE TG + +EAGAL+LAD G IDE DKM+ D+ IHEA+EQQTIS++KAGI
Sbjct: 510 TAAVVKDEETGDFTIEAGALMLADNGICAIDEFDKMDLSDQVAIHEAMEQQTISIAKAGI 569
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP GR+NR + IN+ +MSRFDL FV++DE +E +D +A
Sbjct: 570 QATLNARTSILAAANPIGGRYNRKTTLRNNINMSAPIMSRFDLFFVVLDECNESVDRHLA 629
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKS 973
+HI+ + R + + P+ + L++YI YAR P ++ E+ EI K Y ++R +
Sbjct: 630 KHIVDIHRLRDDAMQPEFSTEQLQRYIRYAR-TFKPKLNTESCAEIVKKYKQLRMDDAQG 688
Query: 974 SEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDE 1030
+ + IT RQLE++IRLSEA AR +T EA L+ ++ + D+
Sbjct: 689 AGK--NSYRITVRQLESMIRLSEAIARANCVDDITPAFVNEAYSLLRQSIIHVERDD 743
Score = 132 bits (328), Expect = 3e-29
Identities = 104/415 (25%), Positives = 187/415 (45%), Gaps = 86/415 (20%)
Query: 4 EEIIERFLRFLREYAEE-----------GEEPLYIGKIKDLLAITPKRSIAINWMHLNSF 52
E + E F FL ++++ +E Y+ +I L A+ ++ +++ HL S+
Sbjct: 70 ESVREAFEEFLLSFSDDRVAGGDALPSASQEKYYVQQIHGL-AMYEIHTVYVDYKHLTSY 128
Query: 53 DPELAEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHAR--------------- 94
+ LA ++E A+Q ++++ + R + R +A
Sbjct: 129 NDVLALAIVEQYYRFSPFLLRALQKLIEKFEPEYYRSSLSRENASLSPNFKASDKTFALA 188
Query: 95 FYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYE 154
FYNLP ++++ + I +L + G VTR +E++P ++ F+C++C H +V +
Sbjct: 189 FYNLPFRSTIRDLRTDRIGRLTTITGTVTRTSEVRPELAQGTFICEEC-HTVVSNVEQAF 247
Query: 155 GFVAVKKC--EKCGSKNV-QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDI 211
+ +C E C +K +L++ +S F ++Q RIQ+ + G MPR +D IL DI
Sbjct: 248 RYTEPTQCPNELCANKRSWRLNISQSSFQDWQKVRIQENSNEIPTGSMPRTLDVILRGDI 307
Query: 212 VDTAMPGDRVVVVGILRVVQEKRE-KVP-------------------------------- 238
V+ A GD+ GIL V + + +P
Sbjct: 308 VERAKAGDKCAFTGILIAVPDVSQLGIPGVKPEAYRDSRNFGGRDADGVTGLKSLGVRDL 367
Query: 239 TFKKVIEVNYIEP--------------VSKEIEELE-----ITPEEEQKIRELAKRKDIV 279
T+K ++P S+ IEE + ++ EE +R + I
Sbjct: 368 TYKLSFLACMVQPDDANDKSGADVRGDGSQGIEEQDEFLQSLSQEEIDDLRAMVHSDHIY 427
Query: 280 DAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ +S+AP++YG+ +KKGI L L GGV + P+G LRGD+++ +VGDP +K
Sbjct: 428 SRLTNSLAPSVYGHEIIKKGILLQLMGGVHKLTPEGINLRGDLNICIVGDPSTSK 482
>gi|6981192 minichromosome maintenance deficient (S. cerevisiae) 5 (cell division
cycle 46) [Homo sapiens] >gi|1232079|dbj|BAA12176.1|
(D83986) huMCM5 [Homo sapiens]
Length = 733
Score = 193 bits (485), Expect = 1e-47
Identities = 115/314 (36%), Positives = 187/314 (58%), Gaps = 14/314 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 415 TASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 474
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K + I+ PT++SRFD+IF++ DE +E D +A
Sbjct: 475 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEVRDVMLA 533
Query: 914 RHILRVRRG---ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKS- 969
+H++ + +++ V +I L+K+IAY R P +S EA E+++ Y+ MR
Sbjct: 534 KHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRTGP 593
Query: 970 VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD 1029
V IPIT RQLEA++R++EA ++M+L P T D EA++L + + A+
Sbjct: 594 VSTRGTVTASSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALS 653
Query: 1030 ETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEKQE 1087
T V + LS++E+ +L+ G+++ + I+++ K +
Sbjct: 654 GT-LSGVEGFTSQEDQEMLSRIEK------QLKRRFAIGSQVSEHSIIKDFTKQKYPEHA 706
Query: 1088 AREILEKLLEQGQI 1101
++L+ +L +G+I
Sbjct: 707 IHKVLQLMLRRGEI 720
Score = 133 bits (332), Expect = 9e-30
Identities = 94/364 (25%), Positives = 176/364 (47%), Gaps = 36/364 (9%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ RF FLR+Y + + K +D L KR I + L SFD +
Sbjct: 28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDED 83
Query: 56 LAEEVLENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAE 110
LA+ + + P E + E+A + + E E + I + ++ + ++
Sbjct: 84 LADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSD 143
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--EKCG 166
++ L+++ G++ + ++ + C+ C + + + + EG+ +KC ++ G
Sbjct: 144 MMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAG 203
Query: 167 SKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRV 221
LD +K K V+FQ ++Q+ P+ + G+MPR + + D +PG+RV
Sbjct: 204 RPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRV 263
Query: 222 VVVGILRV------VQEKREKV-----PTFKKVIEVNYIEPVSKEIEELEITPEEEQKIR 270
++GI + R++V ++ +V+ + S ++P+EE++ R
Sbjct: 264 TIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFR 323
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
LA ++ + I SIAP+I+G ++KK IA LFGG + LPDG RGDI++L++GDP
Sbjct: 324 RLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDP 383
Query: 331 GVAK 334
G AK
Sbjct: 384 GTAK 387
>emb|CAB05110.1| (Z82244) bK286B10.3 (minichromosome maintenance deficient (S.
cerevisiae) 5 (cell division cycle 46) (DNA Replication
Licensing Factor, P1-CDC46) (isoform 1)) [Homo sapiens]
Length = 733
Score = 193 bits (485), Expect = 1e-47
Identities = 114/315 (36%), Positives = 191/315 (60%), Gaps = 16/315 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 415 TASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 474
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K + I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 475 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDM-LA 532
Query: 914 RHILRVRRG---ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
+H++ + +++ V +I L+K+IAY R P +S EA E+++ Y+ MR
Sbjct: 533 KHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGA 592
Query: 971 KKSSEEEIK--PIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
++ + + IPIT RQLEA++R++EA ++M+L P T D EA++L + + A+
Sbjct: 593 RQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL 652
Query: 1029 DETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEKQ 1086
T V + LS++E+ +L+ G+++ + I+++ K +
Sbjct: 653 SGT-LSGVEGFTSQEDQEMLSRIEK------QLKRRFAIGSQVSEHSIIKDFTKQKYPEH 705
Query: 1087 EAREILEKLLEQGQI 1101
++L+ +L +G+I
Sbjct: 706 AIHKVLQLMLRRGEI 720
Score = 133 bits (332), Expect = 9e-30
Identities = 94/364 (25%), Positives = 176/364 (47%), Gaps = 36/364 (9%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ RF FLR+Y + + K +D L KR I + L SFD +
Sbjct: 28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDED 83
Query: 56 LAEEVLENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAE 110
LA+ + + P E + E+A + + E E + I + ++ + ++
Sbjct: 84 LADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSD 143
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--EKCG 166
++ L+++ G++ + ++ + C+ C + + + + EG+ +KC ++ G
Sbjct: 144 MMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAG 203
Query: 167 SKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRV 221
LD +K K V+FQ ++Q+ P+ + G+MPR + + D +PG+RV
Sbjct: 204 RPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRV 263
Query: 222 VVVGILRV------VQEKREKV-----PTFKKVIEVNYIEPVSKEIEELEITPEEEQKIR 270
++GI + R++V ++ +V+ + S ++P+EE++ R
Sbjct: 264 TIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFR 323
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
LA ++ + I SIAP+I+G ++KK IA LFGG + LPDG RGDI++L++GDP
Sbjct: 324 RLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDP 383
Query: 331 GVAK 334
G AK
Sbjct: 384 GTAK 387
>dbj|BAB11083.1| (AB010698) MCM3 homolog [Arabidopsis thaliana]
Length = 776
Score = 192 bits (483), Expect = 2e-47
Identities = 114/268 (42%), Positives = 159/268 (58%), Gaps = 40/268 (14%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKMND+DR IHE +EQQT++++KAGI
Sbjct: 369 TAAVTSDQETGERRLEAGAMVLADKGIVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGI 428
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +V+AAANP G ++R ++ I LP +L+SRFDL+F+++D+ D IDS I+
Sbjct: 429 HASLNARCSVVAAANPIYGTYDRSLTPTKNIGLPDSLLSRFDLLFIVLDQMDAGIDSMIS 488
Query: 914 RHILRVRR---------------------GESEVVTP-----------KIPHD------L 935
H+LR+ R ESE+ HD
Sbjct: 489 EHVLRMHRYKNDRGEAGPDGSLPYAREDNAESEMFVKYNQTLHGKKKRGQTHDKTLTIKF 548
Query: 936 LRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLS 995
L+KYI YA+ + P +++EA E I + Y +R + S + +PITAR LE +IRL+
Sbjct: 549 LKKYIHYAKHRITPKLTDEASERIAEAYADLRNA--GSDTKTGGTLPITARTLETIIRLA 606
Query: 996 EAHARMRLSPIVTREDAREAIKLMEYTL 1023
AHA+M+LS VT+ DA A+KLM + +
Sbjct: 607 TAHAKMKLSSEVTKADAEAALKLMNFAI 634
Score = 146 bits (364), Expect = 2e-33
Identities = 97/325 (29%), Positives = 169/325 (51%), Gaps = 16/325 (4%)
Query: 23 EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL----AAEDAIQII 78
+ +Y+ +IK L+ R I IN ++ E+A +L+NP E + AA +A + I
Sbjct: 20 DSMYMEEIKALVHQKRHRLI-INISDIHHHFREVASRILKNPNEYMQSFCDAATEATRAI 78
Query: 79 LKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFV 138
+ + ++ + Y + + + +E+ ++ I ++ VEG+VT+ + ++P V +V
Sbjct: 79 DPKYLKEGELVLVGFEGYFVSRVVTPRELLSDFIGSMVCVEGIVTKCSLVRPKVVKSVHF 138
Query: 139 CKDCG-------HEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFVNFQMFRIQDRP 191
C G ++ G V + +K + + K+ + Q IQ+ P
Sbjct: 139 CPSTGEFTNRDYRDITSHAGLPTGSVYPTRDDK--GNLLVTEYGLCKYKDHQTLSIQEVP 196
Query: 192 ETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV--QEKREKVPTFKKVIEVNYI 249
E GQ+PR +D I DD+VD+ PGDRV V GI + + + K F+ ++ N I
Sbjct: 197 ENAAPGQLPRSVDVIAEDDLVDSCKPGDRVSVFGIYKALPGKSKGSVNGVFRTILIANNI 256
Query: 250 EPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVP 309
++KE T ++ I+ +A+R D D + S+AP+IYG+ +KK + L + GGV
Sbjct: 257 ALLNKEANAPIYTKQDLDNIKNIARRDDAFDLLARSLAPSIYGHAWIKKAVVLLMLGGVE 316
Query: 310 RTLPDGTRLRGDIHVLLVGDPGVAK 334
+ L +GT LRGDI++++VGDP VAK
Sbjct: 317 KNLKNGTHLRGDINMMMVGDPSVAK 341
>emb|CAA03887.1| (AJ000058) MCM3 homolog [Arabidopsis thaliana]
Length = 776
Score = 192 bits (483), Expect = 2e-47
Identities = 114/268 (42%), Positives = 159/268 (58%), Gaps = 40/268 (14%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKMND+DR IHE +EQQT++++KAGI
Sbjct: 369 TAAVTSDQETGERRLEAGAMVLADKGIVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGI 428
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +V+AAANP G ++R ++ I LP +L+SRFDL+F+++D+ D IDS I+
Sbjct: 429 HASLNARCSVVAAANPIYGTYDRSLTPTKNIGLPDSLLSRFDLLFIVLDQMDAGIDSMIS 488
Query: 914 RHILRVRR---------------------GESEVVTP-----------KIPHD------L 935
H+LR+ R ESE+ HD
Sbjct: 489 EHVLRMHRYKNDRSEAGPDGSLPYAREDNAESEMFVKYNQTLHGKKKRGQTHDKTLTIKF 548
Query: 936 LRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLS 995
L+KYI YA+ + P +++EA E I + Y +R + S + +PITAR LE +IRL+
Sbjct: 549 LKKYIHYAKHRITPKLTDEASERIAEAYADLRNA--GSDTKTGGTLPITARTLETIIRLA 606
Query: 996 EAHARMRLSPIVTREDAREAIKLMEYTL 1023
AHA+M+LS VT+ DA A+KLM + +
Sbjct: 607 TAHAKMKLSSEVTKADAEAALKLMNFAI 634
Score = 146 bits (364), Expect = 2e-33
Identities = 97/325 (29%), Positives = 169/325 (51%), Gaps = 16/325 (4%)
Query: 23 EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL----AAEDAIQII 78
+ +Y+ +IK L+ R I IN ++ E+A +L+NP E + AA +A + I
Sbjct: 20 DSMYMEEIKALVHQKRHRLI-INISDIHHHFREVASRILKNPNEYMQSFCDAATEATRAI 78
Query: 79 LKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFV 138
+ + ++ + Y + + + +E+ ++ I ++ VEG+VT+ + ++P V +V
Sbjct: 79 DPKYLKEGELVLVGFEGYFVSRVVTPRELLSDFIGSMVCVEGIVTKCSLVRPKVVKSVHF 138
Query: 139 CKDCG-------HEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFVNFQMFRIQDRP 191
C G ++ G V + +K + + K+ + Q IQ+ P
Sbjct: 139 CPSTGEFTNRDYRDITSHAGLPTGSVYPTRDDK--GNLLVTEYGLCKYKDHQTLSIQEVP 196
Query: 192 ETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV--QEKREKVPTFKKVIEVNYI 249
E GQ+PR +D I DD+VD+ PGDRV V GI + + + K F+ ++ N I
Sbjct: 197 ENAAPGQLPRSVDVIAEDDLVDSCKPGDRVSVFGIYKALPGKSKGSVNGVFRTILIANNI 256
Query: 250 EPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVP 309
++KE T ++ I+ +A+R D D + S+AP+IYG+ +KK + L + GGV
Sbjct: 257 ALLNKEANAPIYTKQDLDNIKNIARRDDAFDLLARSLAPSIYGHAWIKKAVVLLMLGGVE 316
Query: 310 RTLPDGTRLRGDIHVLLVGDPGVAK 334
+ L +GT LRGDI++++VGDP VAK
Sbjct: 317 KNLKNGTHLRGDINMMMVGDPSVAK 341
>emb|CAA10166.1| (AJ012750) MCM3 protein [Pisum sativum]
Length = 656
Score = 191 bits (481), Expect = 3e-47
Identities = 107/272 (39%), Positives = 159/272 (58%), Gaps = 44/272 (16%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKMND+DR IHE +EQQT++++KAGI
Sbjct: 252 TAAVTSDQETGERRLEAGAMVLADRGVVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGI 311
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +V+AAANP G ++R ++ I LP +L+SRFDL+F+++D+ D ID +I+
Sbjct: 312 HASLNARCSVVAAANPIYGTYDRSLTPTKNIGLPDSLLSRFDLLFIVLDQMDPDIDRQIS 371
Query: 914 RHILRVRRGESEVVTPKIPHD--------------------------------------- 934
H+LR+ R S + + HD
Sbjct: 372 EHVLRMHRFRSAIDGGEAAHDGSARYGKKEEADTESSVFVKYNRMLHGKKTDRGRKRDTL 431
Query: 935 ---LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEAL 991
L+KYI YA+ + P +++EA ++I Y ++R + S+ + +PITAR LE +
Sbjct: 432 TIKFLKKYIHYAKHRIQPDLTDEASDQIATAYAELRNA--NSNAKTGGTLPITARTLETI 489
Query: 992 IRLSEAHARMRLSPIVTREDAREAIKLMEYTL 1023
IRLS AHA+++LS VT+ D A+K++ + +
Sbjct: 490 IRLSTAHAKLKLSRKVTKSDVDAALKILNFAI 521
Score = 122 bits (304), Expect = 2e-26
Identities = 72/224 (32%), Positives = 123/224 (54%), Gaps = 7/224 (3%)
Query: 118 VEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVK--KCEKCGSKNVQLDVE 175
VEG++T+ + ++P V +V C G + + + +N L V
Sbjct: 1 VEGIITKCSLVRPKVVKSVHFCPTTGSFTSRDYRDITSNLGLPTGSVYPTRDENGNLLVT 60
Query: 176 K---SKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV-- 230
+ K+ + Q +Q+ PE GQ+PR +D I DD+VD+ PGDRV +VGI + +
Sbjct: 61 EYGLCKYKDHQTLSMQEVPENSAPGQLPRTVDVIAEDDLVDSGKPGDRVAIVGIYKALPG 120
Query: 231 QEKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAI 290
+ K F+ V+ N + ++KE + E+ + I+++A+R D D + +S+AP+I
Sbjct: 121 KSKGSVNGVFRTVLIANNVALLNKEANAPIYSTEDLKNIKKIAERDDTFDLLGNSLAPSI 180
Query: 291 YGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+G+ +KK + L + GV + L +GT LRGDI++++VGDP VAK
Sbjct: 181 HGHSWIKKAVILLMLSGVEKNLKNGTHLRGDINMMMVGDPSVAK 224
>sp|P49731|MIS5_SCHPO MIS5 PROTEIN >gi|11274808|pir||T43423 probable replication licensing
factor mis5 - fission yeast (Schizosaccharomyces pombe)
>gi|829086|dbj|BAA06729.1| (D31960) unknown
[Schizosaccharomyces pombe]
Length = 868
Score = 191 bits (481), Expect = 3e-47
Identities = 105/237 (44%), Positives = 151/237 (63%), Gaps = 3/237 (1%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVV+DE TG + +EAGAL+ AD G IDE DKM+ D+ IHEA+EQQTIS++KAGI
Sbjct: 510 TAAVVKDEETGDFTIEAGALMSADNGICAIDEFDKMDLSDQVAIHEAMEQQTISIAKAGI 569
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP GR+NR + IN+ +MSRFDL FV++DE +E +D +A
Sbjct: 570 QATLNARTSILAAANPIGGRYNRKTTLRNNINMSAPIMSRFDLFFVVLDECNESVDRHLA 629
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKS 973
+HI+ + R + + P+ + L++YI YAR P ++ E+ EI K Y ++R +
Sbjct: 630 KHIVDIHRLRDDAMQPEFSTEQLQRYIRYAR-TFKPKLNTESCAEIVKKYKQLRMDDAQG 688
Query: 974 SEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDE 1030
+ + IT RQLE++IRLSEA AR +T EA L+ ++ + D+
Sbjct: 689 AGK--NSYRITVRQLESMIRLSEAIARANCVDDITPAFVNEAYSLLRQSIIHVERDD 743
Score = 130 bits (323), Expect = 1e-28
Identities = 104/415 (25%), Positives = 187/415 (45%), Gaps = 86/415 (20%)
Query: 4 EEIIERFLRFLREYAEE-----------GEEPLYIGKIKDLLAITPKRSIAINWMHLNSF 52
E + E F FL ++++ +E Y+ +I L A+ ++ +++ HL S+
Sbjct: 70 ESVREAFEEFLLSFSDDRVAGGDALPSASQEKYYVQQIHGL-AMYEIHTVYVDYKHLTSY 128
Query: 53 DPELAEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHAR--------------- 94
+ LA ++E A+Q ++++ + R + R +A
Sbjct: 129 NDVLALAIVEQYYRFSPFLLRALQKLIEKFEPEYYRSSLSRENASLSPNFKASDKTFALA 188
Query: 95 FYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYE 154
FYNLP ++++ + I +L + G VTR +E++P ++ F+C++C H +V +
Sbjct: 189 FYNLPFRSTIRDLRTDRIGRLTTITGTVTRTSEVRPELAQGTFICEEC-HTVVSNVEQAF 247
Query: 155 GFVAVKKC--EKCGSK-NVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDI 211
+ +C E C +K + +L++ +S F + Q RIQ+ + G MPR +D IL DI
Sbjct: 248 RYTEPTQCPNELCANKRSWRLNISQSSFQDCQKVRIQENSNEIPTGSMPRTLDVILRGDI 307
Query: 212 VDTAMPGDRVVVVGILRVVQEKRE-KVP-------------------------------- 238
V+ A GD+ GIL V + + +P
Sbjct: 308 VERAKAGDKCAFTGILIAVPDVSQLGIPGVKPEAYRDSRNFGGRDADGVTGLKSLGVRDL 367
Query: 239 TFKKVIEVNYIEP--------------VSKEIEELE-----ITPEEEQKIRELAKRKDIV 279
T+K ++P S+ IEE + ++ EE +R + I
Sbjct: 368 TYKLSFLACMVQPDDANDKSGADVRGDGSQGIEEQDEFLQSLSQEEIDDLRAMVHSDHIY 427
Query: 280 DAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ +S+AP++YG+ +KKGI L L GGV + P+G LRGD+++ +VGDP +K
Sbjct: 428 SRLSNSLAPSVYGHEIIKKGILLQLMGGVHKLTPEGINLRGDLNICIVGDPSTSK 482
>pir||I38080 replication licensing factor MCM5 - human
Length = 734
Score = 191 bits (480), Expect = 4e-47
Identities = 112/315 (35%), Positives = 189/315 (59%), Gaps = 15/315 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 415 TASVMRDPSSRNFIMEGGAWVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 474
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K + I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 475 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLA 533
Query: 914 RHILRVRRG---ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
+H++ + +++ V +I L+K+IAY R P +S EA E+++ Y+ MR
Sbjct: 534 KHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRTGA 593
Query: 971 KKSSEEEIK--PIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAV 1028
++ + + IPIT R +EA++R++EA ++M+L P T D EA++L + + A+
Sbjct: 594 RQHERDSDRRSSIPITVRHVEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAAL 653
Query: 1029 DETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDD--ILEEAKKFGIEKQ 1086
T V + LS++E+ +L+ G+++ + I+++ K +
Sbjct: 654 SGT-LSGVEGFTSQEDQEMLSRIEK------QLKRRFAIGSQVSEHSIIKDFTKQKYPEH 706
Query: 1087 EAREILEKLLEQGQI 1101
++L+ +L +G+I
Sbjct: 707 AIHKVLQLMLPRGEI 721
Score = 132 bits (328), Expect = 3e-29
Identities = 93/364 (25%), Positives = 176/364 (47%), Gaps = 36/364 (9%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-------IAINWMHLNSFDPE 55
+ ++ RF FLR+Y + + K +D L KR I + L SFD +
Sbjct: 28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFDED 83
Query: 56 LAEEVLENPEECILAAEDAIQIILKEDIM-----REDVPRIHARFYNLPKTLMVKEIGAE 110
LA+ + + P E + E+A + + E E + I + ++ + ++
Sbjct: 84 LADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSD 143
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKC--EKCG 166
++ L+++ G++ + ++ + C+ C + + + + EG+ +KC ++ G
Sbjct: 144 MMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLSNIAMRPGLEGYALPRKCNTDQAG 203
Query: 167 SKNVQLDV-----EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRV 221
LD +K K V+FQ ++Q+ P+ + G++PR + + D +PG+RV
Sbjct: 204 RPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEVPRHMQLYCDRYLCDKVVPGNRV 263
Query: 222 VVVGILRV------VQEKREKV-----PTFKKVIEVNYIEPVSKEIEELEITPEEEQKIR 270
++GI + R++V ++ +V+ + S ++P+EE++ R
Sbjct: 264 TIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFR 323
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
LA ++ + I SIAP+I+G ++KK IA LFGG + LPDG RGDI++L++GDP
Sbjct: 324 RLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDP 383
Query: 331 GVAK 334
G AK
Sbjct: 384 GTAK 387
>pir||T03920 replication licensing factor MCM7 - Caenorhabditis elegans
>gi|2291237|gb|AAB65356.1| (AF016427) Contains similarity
to Pfam domain: PF00493 (MCM), Score=834.6,
E-value=1.1e-247, N=1 [Caenorhabditis elegans]
Length = 730
Score = 191 bits (480), Expect = 4e-47
Identities = 111/313 (35%), Positives = 174/313 (55%), Gaps = 19/313 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV++D TG LE GALVLADGG IDE DKM D DR+ IHE +EQQTIS++KAGI
Sbjct: 424 TAAVMKDPVTGEMSLEGGALVLADGGICCIDEFDKMMDHDRTAIHEVMEQQTISIAKAGI 483
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNART +IAAANP GR+N + I + ++LP L+SRFDLI ++ D+ D + D +A
Sbjct: 484 MTTLNARTAIIAAANPAYGRYNPNRSIEQNVDLPAALLSRFDLILLMQDKADRENDKILA 543
Query: 914 RHILRVRRGESEVVTPK---IPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSV 970
HI V + K I + LR+YI+ K P + E I + YV+MR+
Sbjct: 544 EHITYVHQHGCHPNREKKDLISLETLREYISLC-KTYTPTVDPALRERIVEAYVEMRRDA 602
Query: 971 KKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDE 1030
+ SS+ P ++ R + ++R++ A A++RLS IV D EA++LM++ + ++
Sbjct: 603 RYSSD----PTFVSPRMILGIVRMATARAKLRLSTIVDESDVEEALRLMQFAKDSLRPEQ 658
Query: 1031 TGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEARE 1090
+ ++++ V+ ++ +L I + ++ + GI + ++
Sbjct: 659 -----------NKIEKRMAPVDAAFAVLRELYHADNAPIAISNAIQRCARKGISEVALKK 707
Query: 1091 ILEKLLEQGQIYM 1103
L++ G + M
Sbjct: 708 CLDQYTANGLLVM 720
Score = 100 bits (247), Expect = 8e-20
Identities = 74/240 (30%), Positives = 123/240 (50%), Gaps = 14/240 (5%)
Query: 104 VKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAV---- 159
V+ I A I L+ ++GVV R TE+KP V + C C E+ K + V
Sbjct: 162 VRNIKATEIGHLVSMKGVVIRATEVKPCVEVMTYTCDTCAAEVYQPVKGMQFTPPVNCPN 221
Query: 160 KKC-EKCGSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPG 218
K+C E + + + + SKFV FQ +IQ+ E + G +PR + + ++ G
Sbjct: 222 KECVEAKANGRLHMQLRGSKFVKFQELKIQELSEQVPVGSIPRTMTVHVYGEMTRKCNTG 281
Query: 219 DRVVVVGILRVVQEKREKVPTFKKVIEVNYIEPVSKEIEELEITPE----EEQKIRELAK 274
+ V V G+ + + + PT V + Y+E + I L+ P + ++ L +
Sbjct: 282 NVVHVSGVFLPIMQSGFR-PTGGLVAD-TYLE--AHYINNLDDNPTFNGVQSAELEVLRR 337
Query: 275 RKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ D + + SIAP I+G+ +VKK + +AL GG + +G ++RG I+VL++GDPGVAK
Sbjct: 338 KGDNYETLAASIAPEIFGHVDVKKCLLMALVGGNDNS-SNGMKIRGCINVLMMGDPGVAK 396
>gb|AAF17244.1|AF203971_1 (AF203971) minichromosome maintenance protein 2 homolog [Entamoeba
histolytica]
Length = 883
Score = 190 bits (479), Expect = 5e-47
Identities = 110/239 (46%), Positives = 154/239 (64%), Gaps = 19/239 (7%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV +D G W LE GALVLAD G LIDE DKM+D+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 622 TAAVKKDSMNGEWALEGGALVLADEGVCLIDEFDKMDDQDRTSIHEAMEQQSISISKAGI 681
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR +VIAAANPK G++N K +++ +NL ++SRFDLI ++ D D ++A
Sbjct: 682 VTSLKARCSVIAAANPKTGKYNPNKNLNQNVNLTEPIISRFDLIMIVRDVVDYVKVYKLA 741
Query: 914 RHIL-----------RVRRGESEVV--TPKIPHDLLRKYIAYARKNVHPVIS-EEAMEEI 959
+ ++ + R + +V T I H LL+KYIAYAR+N HP S + I
Sbjct: 742 QFVVESHSINHPEASQKRESIAPIVNKTNIISHVLLKKYIAYARQNCHPKWSGTVGSQMI 801
Query: 960 EKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKL 1018
++ Y++MRK K + +TARQ+EA+ RLSEAHA++ L +VT ED + A+K+
Sbjct: 802 QQAYIEMRKCCDKYHTGQ-----VTARQIEAINRLSEAHAKIHLRGVVTTEDVKIALKI 855
Score = 169 bits (424), Expect = 1e-40
Identities = 119/341 (34%), Positives = 182/341 (52%), Gaps = 13/341 (3%)
Query: 5 EIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENP 64
E ++ FL + E E + +YI I+ +++ S+ ++++HL LA+ ++ P
Sbjct: 256 ETLKIFLLYYTE-TETSKNVVYIISIRKMVSRN-SGSLDVSFLHLAKSSKLLAQWIVLCP 313
Query: 65 EECI-LAAEDAIQIILKEDIMREDVP-RIHARFYNLPKTLMVKEIGAEHINKLIQVEGVV 122
I + +E A Q L +D+ +++ R + + ++++ HIN LI+V G+V
Sbjct: 314 SSVIPIFSEAATQATLLLYPDYKDISTQVNVRIVDYTTRIALRDLRHCHINTLIRVVGIV 373
Query: 123 TRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
TRVT I P + + ++C C + K ++ C C SK +DV+ + +
Sbjct: 374 TRVTAIFPQLKAVKYICSVCQARLGPYFINKEMNKVPQLQVCTVCQSKGPFSIDVQNTIY 433
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q IQ+ P ++ G +PR D ILL D++D A PG+ + + G + E +
Sbjct: 434 QNYQKITIQEPPNSVSAGNVPRTKDVILLGDLIDKAQPGEEIDINGNVCPNYETGLNRNF 493
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F VIEVN IE S ++ IT EEEQ+IR LA I I++SIAPAIYG+
Sbjct: 494 GFPVFCTVIEVNTIEKRSGDVISTTITHEEEQEIRRLANNPQIFQIIINSIAPAIYGHDA 553
Query: 296 VKKGIALALFGGVPRTLPD--GTRLRGDIHVLLVGDPGVAK 334
K IALALFGG R L D R RGDI+VLL+GDPG AK
Sbjct: 554 SKAAIALALFGGEQRVLVDKGNHRTRGDINVLLLGDPGTAK 594
>pir||T39991 minichromosome maintenance protein mcm7p [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|3236468|gb|AAC23693.1|
(AF070481) minichromosome maintenance protein Mcm7p
[Schizosaccharomyces pombe] >gi|3378510|emb|CAA20099.1|
(AL031158) minichromosome maintenance protein mcm7p
[Schizosaccharomyces pombe]
Length = 760
Score = 190 bits (478), Expect = 7e-47
Identities = 119/318 (37%), Positives = 179/318 (55%), Gaps = 12/318 (3%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV+RD T VLE GALVLAD G IDE DKM++ DR+ IHE +EQQTIS+SKAGI
Sbjct: 437 TAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGI 496
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLNART+++AAANP GR+N INLP L+SRFD++F+++D P + D +A
Sbjct: 497 TTTLNARTSILAAANPLYGRYNPKVAPIHNINLPAALLSRFDILFLILDTPSRETDEHLA 556
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+H+ V + P D ++R YI+ AR+ PV+ ++ + + YV++R++ K
Sbjct: 557 QHVTYVHMHNEQPKMDFEPLDPNMIRHYISSARQ-YRPVVPKDVCDYVTGAYVQLRQNQK 615
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD-E 1030
+ E + T R L A++R+ +A AR+R S V D EA++LM + + D +
Sbjct: 616 RDEANERQFAHTTPRTLLAILRMGQALARLRFSNRVEIGDVDEALRLMSVSKSSLYDDLD 675
Query: 1031 TGQIDVTILEVGQSARKLSKVER-ILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEAR 1089
D TI K+ K+ R +L+ I +EG +E+ + I E G +
Sbjct: 676 PSSHDTTI------TSKIYKIIRDMLNSIPDVEG-NERSLTLRAIRERVLAKGFTEDHLI 728
Query: 1090 EILEKLLEQGQIYMPENG 1107
+++ + G + NG
Sbjct: 729 NTIQEYTDLGVLLTTNNG 746
Score = 141 bits (351), Expect = 5e-32
Identities = 103/368 (27%), Positives = 175/368 (46%), Gaps = 53/368 (14%)
Query: 18 AEEGEEPLYIGKIKDLLAITPKRS---IAINWMHLNSFDP-------------------- 54
++ G+EP K D+L R I ++ L FDP
Sbjct: 44 SDAGDEPFLKSKYMDILQKISNRESNVINVDLNDLYEFDPSDTQLLHNIESNAKRFVELF 103
Query: 55 -ELAEEVLENPEECILAAEDAIQIILKEDIMR-EDVPRIHARF-------YNL------- 98
+ A+ ++ P I + + +I+++ + R E++ H F Y+L
Sbjct: 104 SQCADALMPPPTVEINYRNEVLDVIMQQRVQRNENIDPEHKGFPPELTRGYDLYFRPVTR 163
Query: 99 -PKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFV 157
K V+++ E++ L+ V G+VTR +++KP ++ + C CG+E V Q+ + F+
Sbjct: 164 NKKPFSVRDLRGENLGSLLTVRGIVTRTSDVKPSLTVNAYTCDRCGYE-VFQEIRQKTFL 222
Query: 158 AVKKC--EKCGSKNVQ----LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDI 211
+ +C ++C + + + SKF+ FQ +IQ+ + G +PR + L I
Sbjct: 223 PMSECPSDECKKNDAKGQLFMSTRASKFLPFQEVKIQELTNQVPIGHIPRSLTVHLYGAI 282
Query: 212 VDTAMPGDRVVVVGILRVV-----QEKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEE 266
+ PGD V + GI + R + T +E +Y+ + K +E TP+ E
Sbjct: 283 TRSVNPGDIVDISGIFLPTPYTGFRAMRAGLLT-DTYLECHYVSQIIKNYTNIEKTPQSE 341
Query: 267 QKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLL 326
I EL + ++ + + SIAP IYG+ +VKK + L L GGV + L DG R+RGDI++ L
Sbjct: 342 AAIAELNQGGNVYEKLAKSIAPEIYGHEDVKKALLLLLVGGVTKELGDGMRIRGDINICL 401
Query: 327 VGDPGVAK 334
GDPGVAK
Sbjct: 402 TGDPGVAK 409
>sp|P43299|PROL_ARATH PROLIFERA PROTEIN >gi|675491|gb|AAC37429.1| (L39954) contains
MCM2/3/5 family signature; PROSITE; PS00847; disruption
leads to early lethal phenotype; similar to MCM2/3/5
family, most similar to YBR1441 [Arabidopsis thaliana]
Length = 716
Score = 190 bits (477), Expect = 9e-47
Identities = 117/311 (37%), Positives = 183/311 (58%), Gaps = 11/311 (3%)
Query: 722 ELKEEVMLLLSDVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEGS 781
++K+ ++LLL VG H +++ +K G + +A+ + + H+ ++ G
Sbjct: 343 DIKKALLLLL--VGAPHRQLKDGMKIRGDVHICLMGDPGVAKSQLLK---HIINVAPRGV 397
Query: 782 HSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEAL 841
++ V TAAV+RD+ T VLE GALVLAD G IDE DKM++ DR+ IHE +
Sbjct: 398 YTTGKGSSGVGLTAAVMRDQVTNEMVLEGGALVLADMGICAIDEFDKMDESDRTAIHEVM 457
Query: 842 EQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLV 901
EQQT+S++KAGIT +LNART V+AAANP GR++ + +E INLPP L+SRFDL+++++
Sbjct: 458 EQQTVSIAKAGITTSLNARTAVLAAANPAWGRYDLRRTPAENINLPPALLSRFDLLWLIL 517
Query: 902 DEPDEKIDSEIARHILRVRRGESEVVT--PKIPHDLLRKYIAYARKNVHPVISEEAMEEI 959
D D D E+A+H+L V + E + ++LR YI+ AR+ + P + E E I
Sbjct: 518 DRADMDSDLELAKHVLHVHQTEESPALGFEPLEPNILRAYISAARR-LSPYVPAELEEYI 576
Query: 960 EKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLM 1019
Y +R+ KS+ T R L +++R+S A AR+R S V + D EA++LM
Sbjct: 577 ATAYSSIRQEEAKSNTPHSY---TTVRTLLSILRISAALARLRFSESVAQSDVDEALRLM 633
Query: 1020 EYTLRQIAVDE 1030
+ + + D+
Sbjct: 634 QMSKISLYADD 644
Score = 153 bits (382), Expect = 1e-35
Identities = 101/340 (29%), Positives = 175/340 (50%), Gaps = 27/340 (7%)
Query: 14 LREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECILAAE- 72
L Y +E EE ++G++ + +R ++I ++ PE E ++ + ++
Sbjct: 51 LFNYKDESEE--FLGRLTE----NTRRYVSIFSAAVDELLPEPTEAFPDDDHDILMTQRA 104
Query: 73 ----DAIQIILKEDIMREDVPRIHARFYNLP---KTLMVKEIGAEHINKLIQVEGVVTRV 125
D + + ++ R + ++ P + ++E+ A HI +L+++ G+VTR
Sbjct: 105 DDGTDNPDVSDPHQQIPSEIKRYYEVYFKAPSKGRPSTIREVKASHIGQLVRISGIVTRC 164
Query: 126 TEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCE----KCGSK--NVQLDVEKSKF 179
+++KP ++ AV+ C+DCGHE + Q+ F+ + KC + SK N L + SKF
Sbjct: 165 SDVKPLMAVAVYTCEDCGHE-IYQEVTSRVFMPLFKCPSSRCRLNSKAGNPILQLRASKF 223
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPT 239
+ FQ ++Q+ E + G +PR + L ++ PGD V GI + K
Sbjct: 224 LKFQEAKMQELAEHVPKGHIPRSMTVHLRGELTRKVSPGDVVEFSGIFLPIPYTGFKALR 283
Query: 240 FKKVIEVNYIEPVS-----KEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYR 294
V + Y+E S K+ EE E +EE++I LA+ DI + + S+AP IYG+
Sbjct: 284 AGLVADT-YLEATSVTHFKKKYEEYEFQKDEEEQIARLAEDGDIYNKLSRSLAPEIYGHE 342
Query: 295 EVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
++KK + L L G R L DG ++RGD+H+ L+GDPGVAK
Sbjct: 343 DIKKALLLLLVGAPHRQLKDGMKIRGDVHICLMGDPGVAK 382
>pir||T01507 replication licensing factor MCM7 - Arabidopsis thaliana
>gi|2104530|gb|AAC78698.1| (AF001308) PROLIFERA
[Arabidopsis thaliana] >gi|2104548|gb|AAB57797.1|
(AF001535) AGAA.2, PROLIFERA [Arabidopsis thaliana]
>gi|7268590|emb|CAB80699.1| (AL161493) PROLIFERA
[Arabidopsis thaliana]
Length = 716
Score = 190 bits (477), Expect = 9e-47
Identities = 117/311 (37%), Positives = 183/311 (58%), Gaps = 11/311 (3%)
Query: 722 ELKEEVMLLLSDVGDIHEVIQERLKEIGKILESDASWERIAEVEEVVRDGHVYDLTVEGS 781
++K+ ++LLL VG H +++ +K G + +A+ + + H+ ++ G
Sbjct: 343 DIKKALLLLL--VGAPHRQLKDGMKIRGDVHICLMGDPGVAKSQLLK---HIINVAPRGV 397
Query: 782 HSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEAL 841
++ V TAAV+RD+ T VLE GALVLAD G IDE DKM++ DR+ IHE +
Sbjct: 398 YTTGKGSSGVGLTAAVMRDQVTNEMVLEGGALVLADMGICAIDEFDKMDESDRTAIHEVM 457
Query: 842 EQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLV 901
EQQT+S++KAGIT +LNART V+AAANP GR++ + +E INLPP L+SRFDL+++++
Sbjct: 458 EQQTVSIAKAGITTSLNARTAVLAAANPAWGRYDLRRTPAENINLPPALLSRFDLLWLIL 517
Query: 902 DEPDEKIDSEIARHILRVRRGESEVVT--PKIPHDLLRKYIAYARKNVHPVISEEAMEEI 959
D D D E+A+H+L V + E + ++LR YI+ AR+ + P + E E I
Sbjct: 518 DRADMDSDLELAKHVLHVHQTEESPALGFEPLEPNILRAYISAARR-LSPYVPAELEEYI 576
Query: 960 EKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLM 1019
Y +R+ KS+ T R L +++R+S A AR+R S V + D EA++LM
Sbjct: 577 ATAYSSIRQEEAKSNTPHSY---TTVRTLLSILRISAALARLRFSESVAQSDVDEALRLM 633
Query: 1020 EYTLRQIAVDE 1030
+ + + D+
Sbjct: 634 QMSKISLYADD 644
Score = 153 bits (382), Expect = 1e-35
Identities = 101/340 (29%), Positives = 175/340 (50%), Gaps = 27/340 (7%)
Query: 14 LREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECILAAE- 72
L Y +E EE ++G++ + +R ++I ++ PE E ++ + ++
Sbjct: 51 LFNYKDESEE--FLGRLTE----NTRRYVSIFSAAVDELLPEPTEAFPDDDHDILMTQRA 104
Query: 73 ----DAIQIILKEDIMREDVPRIHARFYNLP---KTLMVKEIGAEHINKLIQVEGVVTRV 125
D + + ++ R + ++ P + ++E+ A HI +L+++ G+VTR
Sbjct: 105 DDGTDNPDVSDPHQQIPSEIKRYYEVYFKAPSKGRPSTIREVKASHIGQLVRISGIVTRC 164
Query: 126 TEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCE----KCGSK--NVQLDVEKSKF 179
+++KP ++ AV+ C+DCGHE + Q+ F+ + KC + SK N L + SKF
Sbjct: 165 SDVKPLMAVAVYTCEDCGHE-IYQEVTSRVFMPLFKCPSSRCRLNSKAGNPILQLRASKF 223
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPT 239
+ FQ ++Q+ E + G +PR + L ++ PGD V GI + K
Sbjct: 224 LKFQEAKMQELAEHVPKGHIPRSMTVHLRGELTRKVSPGDVVEFSGIFLPIPYTGFKALR 283
Query: 240 FKKVIEVNYIEPVS-----KEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYR 294
V + Y+E S K+ EE E +EE++I LA+ DI + + S+AP IYG+
Sbjct: 284 AGLVADT-YLEATSVTHFKKKYEEYEFQKDEEEQIARLAEDGDIYNKLSRSLAPEIYGHE 342
Query: 295 EVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
++KK + L L G R L DG ++RGD+H+ L+GDPGVAK
Sbjct: 343 DIKKALLLLLVGAPHRQLKDGMKIRGDVHICLMGDPGVAK 382
>sp|P49735|MCM2_DROME DNA REPLICATION LICENSING FACTOR MCM2 >gi|852053|gb|AAB36617.1|
(L42762) DNA replication licensing factor [Drosophila
melanogaster] >gi|7299005|gb|AAF54207.1| (AE003678) Mcm2
gene product [Drosophila melanogaster]
Length = 887
Score = 189 bits (476), Expect = 1e-46
Identities = 107/239 (44%), Positives = 150/239 (61%), Gaps = 18/239 (7%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R+ + W LEAGALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 542 TAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 601
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAAANP GR++ SE +NL ++SRFD++ V+ DE D D ++A
Sbjct: 602 VTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLA 661
Query: 914 RHIL--RVRRGESEVVTP-----------KIPHDLLRKYIAYARKNVHPVISEEAMEEIE 960
+ ++ ++ SE P +IP DLLR+YI YA++N+ P ++ ++I
Sbjct: 662 KFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIA 721
Query: 961 KYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLM 1019
K Y ++R+ + +PIT R +E++IR+SEAHARM L V D AI++M
Sbjct: 722 KMYAQLRQESFATGS-----LPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMM 775
Score = 141 bits (353), Expect = 3e-32
Identities = 99/341 (29%), Positives = 167/341 (48%), Gaps = 12/341 (3%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + +E Y +I+ + S +++ L + + LA + E
Sbjct: 177 RTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMS-SFVVSYTDLANKEHVLAYFLPE 235
Query: 63 NPEECI----LAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQV 118
P + + A+D + I IH R LP ++ H+N+L++
Sbjct: 236 APFQMLEIFDKVAKDMVLSIFPT--YERVTTEIHVRISELPLIEELRTFRKLHLNQLVRT 293
Query: 119 EGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKS 177
GVVT T + P +S + C CG+ + + + C +C S +++E++
Sbjct: 294 LGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGSCPECQSTGPFSINMEQT 353
Query: 178 KFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKR--- 234
+ N+Q +Q+ P + G++PR D ILL D+ D PGD + V GI +
Sbjct: 354 LYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNT 413
Query: 235 -EKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGY 293
+ P F VI N++ + +T E+ I++L+K IV+ +V S+AP+IYG+
Sbjct: 414 DQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGH 473
Query: 294 REVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+ +ALALFGG + + ++RGDI++L+ GDPG AK
Sbjct: 474 DYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAK 514
>gb|AAB94861.1| (AF014813) DNA replication licensing factor [Aspergillus nidulans]
Length = 889
Score = 189 bits (476), Expect = 1e-46
Identities = 110/336 (32%), Positives = 183/336 (53%), Gaps = 8/336 (2%)
Query: 6 IIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPE 65
I F FL E+ + +Y KIK L + S+ +++ HL+S L + P
Sbjct: 204 IYREFKAFLTEFTDPTGSSVYGNKIKTLGEVN-SASLEVSYTHLSSTKAVLGYFLANEPT 262
Query: 66 ECILAAED-AIQIILKEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKLIQVEGVVT 123
E + + A+ + L D+ IH R +LP ++++ H+N L++V GVVT
Sbjct: 263 EVLKVFDQVALDVTLFHYPQYHDIHNEIHVRITDLPIVYTLRQLRQSHLNCLVRVSGVVT 322
Query: 124 RVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKFVNF 182
R T + P + +F+C+ C + Q+ V V C+ C S+ + EK+ + N+
Sbjct: 323 RRTGVFPQLKYVMFICQKCNMTLGPYQQESSSEVKVTMCQNCQSRGPFTVSSEKTVYRNY 382
Query: 183 QMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KREKVP 238
Q +Q+ P ++ G++PR + ILL D++D+A PGD + + GI R + + P
Sbjct: 383 QKLTLQESPGSVPAGRLPRQREVILLADLIDSAKPGDEIEITGIYRNSYDAQLNNKNGFP 442
Query: 239 TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKK 298
F +IE N++ + ++T E+E++IR L++ DIV+ I+ SIAP+IYG+++VK
Sbjct: 443 VFATIIEANHVIKSHDQQAGFQLTEEDEREIRALSRDPDIVEKIIRSIAPSIYGHQDVKT 502
Query: 299 GIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+AL+LFGGV + +RGDI+VLL+GDPG AK
Sbjct: 503 AVALSLFGGVRKETQGKMSIRGDINVLLLGDPGTAK 538
Score = 164 bits (410), Expect = 6e-39
Identities = 103/274 (37%), Positives = 140/274 (50%), Gaps = 56/274 (20%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V RD T W LE GALVLAD G LIDE DKMND+DR+ IHEA+EQQTIS+SKAGI
Sbjct: 566 TASVRRDPLTSEWTLEGGALVLADRGTCLIDEFDKMNDQDRTSIHEAMEQQTISISKAGI 625
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVL------------- 900
TL AR V+AAANP GR+N SE + L ++SRFD++ V+
Sbjct: 626 VTTLQARCAVVAAANPIGGRYNSSAPFSENVQLTEPILSRFDILCVVRDLVDPSEDERLA 685
Query: 901 ------------------------------VDEPDEKIDSEIARHILR--------VRRG 922
+DE +ID + R LR R
Sbjct: 686 SFVIESHHRANPSKPLRDEHGNLINADGERIDEEGYRIDDDGIRLPLRPDEIEARNAARD 745
Query: 923 ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIP 982
+ +IP +LLRKYI YAR++ P + + +++ + + MR+ + P
Sbjct: 746 NDDEKEGEIPQELLRKYILYAREHCRPKLYQIDQDKVARLFADMRRESLATG-----AYP 800
Query: 983 ITARQLEALIRLSEAHARMRLSPIVTREDAREAI 1016
IT R LEA++R++EA +MRLS + +D AI
Sbjct: 801 ITVRHLEAIMRIAEAFCKMRLSEYCSAQDIDRAI 834
>sp|P38132|CC47_YEAST CELL DIVISION CONTROL PROTEIN 47 >gi|608169|gb|AAA86309.1| (U14730)
Cdc47p [Saccharomyces cerevisiae]
Length = 845
Score = 189 bits (475), Expect = 2e-46
Identities = 130/400 (32%), Positives = 210/400 (52%), Gaps = 26/400 (6%)
Query: 690 VTIEIPEKLRRFIKCDRVRYVDLVEMLSSMEGELKEEVMLLLSDVGDIHEVIQERLKEIG 749
+T ++ E++ I V + + G L + LLL VG + + + + +K G
Sbjct: 393 LTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRG 452
Query: 750 KI---LESDASWERIAEVEEVVRDGHVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGW 806
I L D + ++ + + ++ G ++ V TAAV++D T
Sbjct: 453 DINVCLMGDPGVAKSQLLKAICK------ISPRGVYTTGKGSSGVGLTAAVMKDPVTDEM 506
Query: 807 VLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGITATLNARTTVIAA 866
+LE GALVLAD G IDE DKM++ DR+ IHE +EQQTIS+SKAGI TLNART+++AA
Sbjct: 507 ILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAA 566
Query: 867 ANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEV 926
ANP GR+N + INLP L+SRFD++F+++D P D ++A H+ V +
Sbjct: 567 ANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQP 626
Query: 927 ---VTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPI 983
TP P +R+YIAYA K PV+SE + + + Y+++R+ K+ + +
Sbjct: 627 DLDFTPVEP-SKMREYIAYA-KTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQA 684
Query: 984 TARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQ 1043
T R L +IRLS+A A++RL+ +V +D EA++L+ + + E +
Sbjct: 685 TPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESL-----------YQETNK 733
Query: 1044 SARKLSKVERILDIIEK-LEGTSEKGAKIDDILEEAKKFG 1082
S S +I II+K L+ T + ++I++ + G
Sbjct: 734 SKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRG 773
Score = 136 bits (338), Expect = 2e-30
Identities = 80/245 (32%), Positives = 129/245 (52%), Gaps = 11/245 (4%)
Query: 100 KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAV 159
K L V++I + + +LI V G++TRV+++KP V + C CG+E V Q+ F +
Sbjct: 223 KPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYE-VFQEVNSRTFTPL 281
Query: 160 KKC--EKCGSKNVQ----LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVD 213
+C E+C + + SKF FQ +IQ+ + + G +PR ++ + +V
Sbjct: 282 SECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVR 341
Query: 214 TAMPGDRVVVVGILRVVQEKREKVPTF----KKVIEVNYIEPVSKEIEELEITPEEEQKI 269
+ PGD V V GI K + +E ++ K+ +T + E+++
Sbjct: 342 SLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERV 401
Query: 270 RELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGD 329
EL D+ + + SIAP IYG +VKK + L L GGV + + DG ++RGDI+V L+GD
Sbjct: 402 MELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGD 461
Query: 330 PGVAK 334
PGVAK
Sbjct: 462 PGVAK 466
>sp|Q91876|MCM7_XENLA DNA REPLICATION LICENSING FACTOR MCM7 (CDC47 HOMOLOG) (X.MCM7)
>gi|1469526|gb|AAB17253.1| (U51234) XMCM7 [Xenopus
laevis]
Length = 720
Score = 188 bits (473), Expect = 3e-46
Identities = 111/279 (39%), Positives = 163/279 (57%), Gaps = 20/279 (7%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV++D TG LE GALVLAD G IDE DKM D DR+ IHE +EQQTIS++KAGI
Sbjct: 414 TAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGI 473
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N K + + I LP L+SRFD+++++ D+PD D +A
Sbjct: 474 MTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDVLWLIQDKPDRDNDLRLA 533
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + + P D L+R+YI ++ P I E + + YV+MRK +
Sbjct: 534 QHITYVHQHSKQPPSQFQPLDMKLMRRYITMCKRK-QPAIPEALADYLTAAYVEMRKEAR 592
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDET 1031
+ + +AR L +++RLS A AR+RL +V +ED EA++LME + + D+
Sbjct: 593 TNKDMTF----TSARTLLSVLRLSTALARLRLEDVVEKEDVNEAMRLMEMSKDSLLGDK- 647
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAK 1070
G ++R + I I ++ EKGA+
Sbjct: 648 ----------GHTSRTQRPADVIFSTIREM--VPEKGAR 674
Score = 130 bits (323), Expect = 1e-28
Identities = 101/354 (28%), Positives = 174/354 (48%), Gaps = 36/354 (10%)
Query: 14 LREYAEEGEEPLYIGKIKDLLAITPKRSIAI--NWMHLNSFDPELAEEVLENPEECILAA 71
L A + LYI + DL P+ AI N + + +E+L +E +
Sbjct: 36 LANIAHREQVALYID-LDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVH 94
Query: 72 EDAIQIILKEDIMRED---------------VPRIHARF---YNLP---KTLMVKEIGAE 110
+DA+ + ++ +M E P + RF + P K +V+++ A+
Sbjct: 95 KDALDVYIEHRLMMEQRGRDPNEMRDSQNQYPPELMRRFELYFKAPSSSKARVVRDVKAD 154
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHE--MVVQQKPYEGFVAV--KKCEKCG 166
I KL+ V G+VTRVTE+KP + A + C CG E +Q + + ++C+
Sbjct: 155 SIGKLVNVRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNR 214
Query: 167 S-KNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVG 225
S + L SKF+ FQ +IQ+ + + G +PR + + + A PGD V + G
Sbjct: 215 SGGRLYLQTRGSKFIKFQELKIQEHSDQVPVGNIPRCMSVYVRGENTRLAQPGDHVGITG 274
Query: 226 I----LRVVQEKREKVPTFKKVIEVNYIEPVSK-EIEELEITPEEEQKIRELAKRKDIVD 280
+ LR + + + +E + + ++K E +EL E+++R++ + +D +
Sbjct: 275 VFLPMLRTGFRQVVQGLLSETYLECHRLVKMNKTEDDELGTEELSEEELRQITE-EDFYE 333
Query: 281 AIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ SIAP IYG+ +VKK + L L GGV + P G ++RG+I++ L+GDPGVAK
Sbjct: 334 KLAASIAPEIYGHEDVKKALLLLLVGGVDNS-PRGMKIRGNINICLMGDPGVAK 386
>pir||T47221 replication licensing factor MCM7 [validated] - African clawed frog
>gi|2231177|gb|AAC60227.1| (U44051) CDC47p [Xenopus
laevis]
Length = 720
Score = 188 bits (473), Expect = 3e-46
Identities = 111/279 (39%), Positives = 163/279 (57%), Gaps = 20/279 (7%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV++D TG LE GALVLAD G IDE DKM D DR+ IHE +EQQTIS++KAGI
Sbjct: 414 TAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGI 473
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N K + + I LP L+SRFD+++++ D+PD D +A
Sbjct: 474 MTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDVLWLIQDKPDRDNDLRLA 533
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + + P D L+R+YI ++ P I E + + YV+MRK +
Sbjct: 534 QHITYVHQHSKQPPSQFQPLDMKLMRRYITMCKRK-QPAIPEALADYLTAAYVEMRKEAR 592
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDET 1031
+ + +AR L +++RLS A AR+RL +V +ED EA++LME + + D+
Sbjct: 593 TNKDMTF----TSARTLLSVLRLSTALARLRLEDVVEKEDVNEAMRLMEMSKDSLLGDK- 647
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGAK 1070
G ++R + I I ++ EKGA+
Sbjct: 648 ----------GHTSRTQRPADVIFSTIREM--VPEKGAR 674
Score = 127 bits (315), Expect = 9e-28
Identities = 99/354 (27%), Positives = 173/354 (47%), Gaps = 36/354 (10%)
Query: 14 LREYAEEGEEPLYIGKIKDLLAITPKRSIAI--NWMHLNSFDPELAEEVLENPEECILAA 71
L A + LYI + DL P+ AI N + + +E+L +E +
Sbjct: 36 LANIAHREQVALYID-LDDLAEEDPELVDAICENTRRYTNLFADAVQELLPQYKEREVVH 94
Query: 72 EDAIQIILKEDIMRED---------------VPRIHARF---YNLP---KTLMVKEIGAE 110
+DA+ + ++ +M E P + RF + P K +V+++ A+
Sbjct: 95 KDALDVYIEHRLMMEQRGRDPNEMRDSQNQYPPELMRRFELYFKAPSSSKARVVRDVKAD 154
Query: 111 HINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHE--MVVQQKPYEGFVAV--KKCEKCG 166
I KL+ + G+VTRVTE+KP + A + C CG E +Q + + ++C+
Sbjct: 155 SIGKLVNIRGIVTRVTEVKPMMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSRECQTNR 214
Query: 167 S-KNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVG 225
S + L SKF+ FQ +IQ+ + + +PR + + + A PGD V + G
Sbjct: 215 SGGRLYLQTRGSKFIKFQELKIQEHSDQVPVWNIPRCMSVYVRGENTRLAQPGDHVGITG 274
Query: 226 I----LRVVQEKREKVPTFKKVIEVNYIEPVSK-EIEELEITPEEEQKIRELAKRKDIVD 280
+ LR + + + +E + + ++K E +EL E+++R++ + +D +
Sbjct: 275 VFLPMLRTGFRQLVQGLLSETYLECHRLVKMNKSEDDELGTEELSEEELRQITE-EDFYE 333
Query: 281 AIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ SIAP IYG+ +VKK + L L GGV + P G ++RG+I++ L+GDPGVAK
Sbjct: 334 KLAASIAPEIYGHEDVKKALLLLLVGGVDNS-PRGMKIRGNINICLMGDPGVAK 386
>pir||S62607 minichromosome maintenance protein, 85K - human (fragment)
>gi|755746|emb|CAA52803.1| (X74796) p85Mcm protein [Homo
sapiens] >gi|1098113|prf||2115257B p85Mcm Protein [Homo
sapiens]
Length = 617
Score = 187 bits (471), Expect = 4e-46
Identities = 111/270 (41%), Positives = 159/270 (58%), Gaps = 18/270 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV+RD +G LE GALVLAD G IDE DKM + DR+ IHE +EQQTIS++KAGI
Sbjct: 313 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGI 372
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N + + + I LP L+SRFDL++++ D PD D +A
Sbjct: 373 LTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 432
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + + P D L+R+YIA R+ P++ E + I YV+MR+
Sbjct: 433 QHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAW 491
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDET 1031
S + +AR L A++RLS A AR+R+ +V +ED EAI+LME + + D+
Sbjct: 492 ASKDATY----TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDK- 546
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKL 1061
GQ+AR + I + +L
Sbjct: 547 ----------GQTARTQRPADVIFATVREL 566
Score = 123 bits (305), Expect = 1e-26
Identities = 83/251 (33%), Positives = 135/251 (53%), Gaps = 24/251 (9%)
Query: 100 KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAV 159
K +++E+ A+ + KL+ V G+VTRV+E+KP + A + C CG E Q F+ +
Sbjct: 43 KPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAE-TYQPIQSPTFMPL 101
Query: 160 KKC--EKCGSK----NVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVD 213
C ++C + + L S+F+ FQ ++Q+ + + G +PR I ++ +
Sbjct: 102 IMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTR 161
Query: 214 TAMPGDRVVVVGIL---------RVVQE-KREKVPTFKKVIEVNYIEPVSKEIEELEITP 263
A PGD V V GI +VVQ E +++++N E E E+T
Sbjct: 162 IAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSE--DDESGAGELTR 219
Query: 264 EEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIH 323
EE ++I E +D + + SIAP IYG+ +VKK + L L GGV ++ P G ++RG+I+
Sbjct: 220 EELRQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNIN 274
Query: 324 VLLVGDPGVAK 334
+ L+GDPGVAK
Sbjct: 275 ICLMGDPGVAK 285
>gi|10242373 mini chromosome maintenance deficient 7 (S. cerevisiae) [Mus
musculus] >gi|2497827|sp|Q61881|MCM7_MOUSE DNA
REPLICATION LICENSING FACTOR MCM7 (CDC47 HOMOLOG)
>gi|2137202|pir||JC4580 replication licensing factor MCM7
- mouse >gi|1136747|dbj|BAA05084.1| (D26091) mCDC47 [Mus
musculus] >gi|1586562|prf||2204259A protein CDC47 [Mus
musculus]
Length = 719
Score = 187 bits (471), Expect = 4e-46
Identities = 112/270 (41%), Positives = 157/270 (57%), Gaps = 18/270 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV+RD +G LE GALVLAD G IDE DKM + DR+ IHE +EQQTIS++KAGI
Sbjct: 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGI 474
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N + + + + LP L+SRFDL++++ D PD D +A
Sbjct: 475 LTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + P D L+R+YIA + P + E + I YV+MR+ +
Sbjct: 535 QHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCHER-QPTVPESLADYITAAYVEMRREAR 593
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDET 1031
S + +AR L A++RLS A AR+R+ IV +ED EAI+LME +
Sbjct: 594 ASKDATY----TSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMSK-------- 641
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKL 1061
D + E GQ+AR + I I +L
Sbjct: 642 ---DSLLGEKGQTARTQRPADVIFATIREL 668
Score = 137 bits (341), Expect = 8e-31
Identities = 107/383 (27%), Positives = 186/383 (47%), Gaps = 62/383 (16%)
Query: 8 ERFLRFLREYAEE---GEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENP 64
E+ +FL+E+ E G++ G LA + ++ ++ + DPEL + + EN
Sbjct: 11 EKVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENA 70
Query: 65 EECILAAEDAIQIILKE----DIMREDVPRIHAR-------------------------- 94
+ D +Q +L E +++ +DV ++
Sbjct: 71 KRYSRLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSEL 130
Query: 95 ------FYNLP---KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHE 145
++ P K +++E+ A+ + KL+ V G+VTRV+E+KP + A + C CG E
Sbjct: 131 MRRFELYFRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAE 190
Query: 146 MVVQQKPYEGFVAVKKC--EKCGSK----NVQLDVEKSKFVNFQMFRIQDRPETLKGGQM 199
Q F+ + C ++C + + L SKFV FQ +IQ+ + + G +
Sbjct: 191 -TYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNI 249
Query: 200 PRFIDGILLDDIVDTAMPGDRVVVVGI----LRVVQEKREKVPTFKKVIEVNYIEPVSKE 255
PR I +L + A PGD V V GI LR ++ + + +E ++I ++K
Sbjct: 250 PRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHWIVKMTKS 309
Query: 256 IEEL----EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRT 311
+++ E++ EE ++I E +D + + SIAP IYG+ +VKK + L L GGV ++
Sbjct: 310 DDDVSGAGELSSEELKQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS 365
Query: 312 LPDGTRLRGDIHVLLVGDPGVAK 334
P G ++RG+IH+ L+GDPGVAK
Sbjct: 366 -PQGMKIRGNIHICLMGDPGVAK 387
>sp|P33993|MCM7_HUMAN DNA REPLICATION LICENSING FACTOR MCM7 (CDC47 HOMOLOG) (P1.1-MCM3)
>gi|2134885|pir||S70583 replication licensing factor MCM7
- human >gi|1255617|dbj|BAA09534.1| (D55716) P1cdc47
[Homo sapiens]
Length = 719
Score = 187 bits (471), Expect = 4e-46
Identities = 111/270 (41%), Positives = 159/270 (58%), Gaps = 18/270 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV+RD +G LE GALVLAD G IDE DKM + DR+ IHE +EQQTIS++KAGI
Sbjct: 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGI 474
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N + + + I LP L+SRFDL++++ D PD D +A
Sbjct: 475 LTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + + P D L+R+YIA R+ P++ E + I YV+MR+
Sbjct: 535 QHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAW 593
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDET 1031
S + +AR L A++RLS A AR+R+ +V +ED EAI+LME + + D+
Sbjct: 594 ASKDATY----TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDK- 648
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKL 1061
GQ+AR + I + +L
Sbjct: 649 ----------GQTARTQRPADVIFATVREL 668
Score = 127 bits (317), Expect = 5e-28
Identities = 104/386 (26%), Positives = 183/386 (46%), Gaps = 63/386 (16%)
Query: 4 EEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLEN 63
+E +++FL+ + E G++ G LA + ++ ++ + DPEL + + EN
Sbjct: 10 KEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICEN 69
Query: 64 PEECILAAEDAIQIILKE----DIMREDVPRIHAR------------------------- 94
DA+Q +L + +++ +DV ++
Sbjct: 70 ARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAE 129
Query: 95 -------FYNLP---KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGH 144
++ P K +++E+ A+ + KL+ V G+VTRV+E+KP + A + C CG
Sbjct: 130 LMRRFELYFQGPSSSKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGA 189
Query: 145 EMVVQQKPYEGFVAVKKC--EKCGSK----NVQLDVEKSKFVNFQMFRIQDRPETLKGGQ 198
E Q F+ + C ++C + + L S+F+ FQ ++Q+ + + G
Sbjct: 190 E-TYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGN 248
Query: 199 MPRFIDGILLDDIVDTAMPGDRVVVVGIL---------RVVQE-KREKVPTFKKVIEVNY 248
+PR I ++ + A PGD V V GI +VVQ E +++++N
Sbjct: 249 IPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNK 308
Query: 249 IEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGV 308
E E E+T EE ++I E +D + + SIAP IYG+ +VKK + L L GGV
Sbjct: 309 SE--DDESGAGELTREELRQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGV 362
Query: 309 PRTLPDGTRLRGDIHVLLVGDPGVAK 334
++ P G ++RG+I++ L+GDPGVAK
Sbjct: 363 DQS-PRGMKIRGNINICLMGDPGVAK 387
>gb|AAC60228.1| (U66710) CDC47-2p [Xenopus laevis]
Length = 720
Score = 187 bits (471), Expect = 4e-46
Identities = 104/239 (43%), Positives = 148/239 (61%), Gaps = 7/239 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV++D TG LE GALVLAD G IDE DKM D DR+ IHE +EQQTIS++KAGI
Sbjct: 414 TAAVMKDPVTGEMTLEGGALVLADQGVCCIDEFDKMMDSDRTAIHEVMEQQTISIAKAGI 473
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N K + + I LP L+SRFDL++++ D+PD D +A
Sbjct: 474 MTTLNARCSILAAANPAYGRYNPKKTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLA 533
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + + P D L+R+YI K+ P I E + + YV+MRK +
Sbjct: 534 QHITYVHQHSKQPPSQFQPMDMKLMRRYITMC-KSKQPAIPESLADYLTAAYVEMRKEAR 592
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDE 1030
+ + +AR L +++RLS A AR+RL +V +ED EA++L E + + D+
Sbjct: 593 TNKDMTF----TSARTLLSILRLSTALARLRLEDVVDKEDVNEAMRLTEMSKDSLQGDK 647
Score = 127 bits (316), Expect = 7e-28
Identities = 93/328 (28%), Positives = 164/328 (49%), Gaps = 39/328 (11%)
Query: 41 SIAINWMHLNSFDPELAEEVLENPEECILAAEDAIQIILKEDIMRED------------- 87
+I N + + +E+L +E + +DA+ + ++ +M E
Sbjct: 64 AICENTRRYTNLFADAVQELLPQYKEREVVHKDALDVYIEHRLMMEQRGRDPNEMRDPHN 123
Query: 88 --VPRIHARF---YNLP---KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVC 139
P + RF + P K +V+++ A+ I KL+ V G+VTRVTE+KP + A + C
Sbjct: 124 QYPPELMRRFELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTC 183
Query: 140 KDCGHE--MVVQQKPYEGFVAV--KKCEKCGS-KNVQLDVEKSKFVNFQMFRIQDRPETL 194
CG E +Q + + ++C+ S + L SKF+ FQ +IQ+ + +
Sbjct: 184 DQCGAETYQPIQSPTFMPLIMCPSRECQTNRSGGRLYLQTRGSKFIKFQELKIQEHSDQV 243
Query: 195 KGGQMPRFIDGILLDDIVDTAMPGDRVVVVGI-LRVVQEKREKVPTFKKVIEVNYIEPVS 253
G +PR + + + A PGD V + G+ L +++ +V + ++ Y+E S
Sbjct: 244 PVGNIPRCMSVYVRGENTRLAQPGDHVGITGVFLPMLRTGFRQV--VQGLLSETYLE--S 299
Query: 254 KEIEELEITPEEEQKIRELAKR-------KDIVDAIVDSIAPAIYGYREVKKGIALALFG 306
+ ++ T ++E +EL++ +D + + SIAP IYG+ +VKK + L L G
Sbjct: 300 HRLVKMNKTDDDELGTQELSEEELRQITDEDFYEKLAASIAPEIYGHEDVKKALLLLLVG 359
Query: 307 GVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
GV + P G ++RG+I+V L+GDPGVAK
Sbjct: 360 GVDHS-PRGMKIRGNINVCLMGDPGVAK 386
>gb|AAF23296.1|AC016661_21 (AC016661) putative minichromosome maintenance (MCM) protein
[Arabidopsis thaliana]
Length = 777
Score = 187 bits (471), Expect = 4e-46
Identities = 117/320 (36%), Positives = 187/320 (57%), Gaps = 27/320 (8%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
T AVV+D T + EAGA+VLADGG IDE DKM + ++++ EA+EQQ +S++KAG+
Sbjct: 437 TVAVVKDSMTNDYAFEAGAMVLADGGLCCIDEFDKMTTEHQALL-EAMEQQCVSVAKAGL 495
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+L+ART+VIAAANP G +NR K ++E + + L+SRFDL+F+L+D+PDE +D +++
Sbjct: 496 VASLSARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDKPDELLDKQVS 555
Query: 914 RHILRVRR--GESEVVTPKIPHD-----LLRK------YIAYARKNVHP----VISEEAM 956
HI+ R G + I + LRK ++A N+ P ++S++A
Sbjct: 556 EHIMSHHRMLGMQTCMQKGILYFQDCGWTLRKMTTFLRFLANCLGNIFPMHGILMSKDAG 615
Query: 957 EEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAI 1016
E I+K+Y+K+R PITARQLE+L+RL++A AR+ L +T +DA + +
Sbjct: 616 EIIQKFYLKLR-----DHNTSADSTPITARQLESLVRLAQARARVDLREEITVQDAMDVV 670
Query: 1017 KLMEYTLRQIAVDETGQIDVTILEVGQSARKLSKVERILDIIEKLEGTSEKGA-KIDDIL 1075
++M+ +L +DE G +D G S +K +K R L ++K +K + ++
Sbjct: 671 EIMKESLYDKLIDEHGVVDFG-RSGGMSQQKEAK--RFLSALDKQSELQQKDCFSVSEMY 727
Query: 1076 EEAKKFGIEKQEAREILEKL 1095
A + G+ + LE L
Sbjct: 728 SLADRIGLRVPDIDTFLENL 747
Score = 127 bits (315), Expect = 9e-28
Identities = 93/313 (29%), Positives = 157/313 (49%), Gaps = 42/313 (13%)
Query: 62 ENPEECILAAEDAIQIILKEDIMR---EDVPRIHARFYNLPKT-LMVKEIGAEHINKLIQ 117
+NP+ I A+ +L + E+V +I+ R +N P++ + +K + A +I KL+
Sbjct: 99 DNPKGVIPCMNAAVHKVLFDQWETNEFENVMKINVRLHNYPESSISLKNLRAAYIGKLVT 158
Query: 118 VEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEG-FVAVKKCEK--CGSKNVQLDV 174
V G V +V+ +KP V+ F C C + + ++ +G F KC+ C SK
Sbjct: 159 VHGTVVKVSTVKPLVTQMAFDCGKC--KTGITREFTDGKFSPPLKCDSHGCKSKTFTPIR 216
Query: 175 EKSKFVNFQMFRIQD--RPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE 232
++ ++FQ R+Q+ +PE + G++PR ++ L++D+VD +PGD V V GI+ V+
Sbjct: 217 SSAQTIDFQKIRVQELQKPEDHEEGRVPRTVECELMEDLVDICIPGDVVTVTGIIGVINN 276
Query: 233 KRE----KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVD-------- 280
+ K T + +IE VS + + + E + A+ D+ D
Sbjct: 277 YMDIGGGKSKTKNQGFYYLFIEAVSVKNTKRQSAFENSEDSSSSAQTADVGDLYSFSQRD 336
Query: 281 -----------------AIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGD 321
I+ S+ P+IYG+ VK GI L+LFGGV + D + +RGD
Sbjct: 337 LEFIVKFKEEYGSDTFRRILHSVCPSIYGHEIVKAGITLSLFGGVRKHSMDRNKVPVRGD 396
Query: 322 IHVLLVGDPGVAK 334
IHV++VGDPG+ K
Sbjct: 397 IHVIIVGDPGLGK 409
>gb|AAG01994.1| (AY007130) similar to Homo sapiens mRNA for hMCM2 with GenBank
Accession Number D28480.1
Length = 351
Score = 187 bits (471), Expect = 4e-46
Identities = 111/270 (41%), Positives = 159/270 (58%), Gaps = 18/270 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV+RD +G LE GALVLAD G IDE DKM + DR+ IHE +EQQTIS++KAGI
Sbjct: 47 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGI 106
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N + + + I LP L+SRFDL++++ D PD D +A
Sbjct: 107 LTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 166
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + + P D L+R+YIA R+ P++ E + I YV+MR+
Sbjct: 167 QHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAW 225
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDET 1031
S + +AR L A++RLS A AR+R+ +V +ED EAI+LME + + D+
Sbjct: 226 ASKDATY----TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDK- 280
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKL 1061
GQ+AR + I + +L
Sbjct: 281 ----------GQTARTQRPADVIFATVREL 300
>dbj|BAA05839.1| (D28480) hMCM2 [Homo sapiens] >gi|1094423|prf||2106167A nuclear
protein MCM2 [Homo sapiens]
Length = 543
Score = 187 bits (471), Expect = 4e-46
Identities = 111/270 (41%), Positives = 159/270 (58%), Gaps = 18/270 (6%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV+RD +G LE GALVLAD G IDE DKM + DR+ IHE +EQQTIS++KAGI
Sbjct: 239 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGI 298
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +++AAANP GR+N + + + I LP L+SRFDL++++ D PD D +A
Sbjct: 299 LTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 358
Query: 914 RHILRVRRGESEVVTPKIPHD--LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
+HI V + + + P D L+R+YIA R+ P++ E + I YV+MR+
Sbjct: 359 QHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAW 417
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDET 1031
S + +AR L A++RLS A AR+R+ +V +ED EAI+LME + + D+
Sbjct: 418 ASKDATY----TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDK- 472
Query: 1032 GQIDVTILEVGQSARKLSKVERILDIIEKL 1061
GQ+AR + I + +L
Sbjct: 473 ----------GQTARTQRPADVIFATVREL 492
Score = 92.4 bits (226), Expect = 2e-17
Identities = 67/214 (31%), Positives = 111/214 (51%), Gaps = 20/214 (9%)
Query: 135 AVFVCKDCGHEMVVQQKPYEGFVAVKKC--EKCGSKN----VQLDVEKSKFVNFQMFRIQ 188
A + C CG E Q F+ + C ++C + + L S+F+ FQ ++Q
Sbjct: 4 ATYTCDQCGAE-TYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQ 62
Query: 189 DRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEK--REKVPTF--KKVI 244
+ + + G +PR I ++ + A PGD V V GI + R+ V + +
Sbjct: 63 EHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYL 122
Query: 245 EVNYIEPVSKEIEEL----EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGI 300
E + I ++K ++ E+T EE ++I E +D + + SIAP IYG+ +VKK +
Sbjct: 123 EAHRIVKMNKSEDDESGAGELTREELRQIAE----EDFYEKLAASIAPEIYGHEDVKKAL 178
Query: 301 ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
L L GGV ++ P G ++RG+I++ L+GDPGVAK
Sbjct: 179 LLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAK 211
>pir||T47222 replication licensing factor MCM6 [validated] - African clawed frog
>gi|2231175|gb|AAC60226.1| (U44050) mis5p [Xenopus
laevis]
Length = 796
Score = 187 bits (470), Expect = 6e-46
Identities = 109/237 (45%), Positives = 155/237 (64%), Gaps = 11/237 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVV+DE + +V+EAGAL+LAD G IDE DKM+ KD+ IHEA+EQQTIS++KAG+
Sbjct: 432 TAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGV 491
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP GR+ R K + +NL +MSRFDL F+LVDE +E D IA
Sbjct: 492 KATLNARTSILAAANPVGGRYERSKSLKHNVNLSAPIMSRFDLFFILVDECNEVTDYAIA 551
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK----S 969
R I+ + E + + +++Y+ +AR+ P I++EA E I + Y ++R+
Sbjct: 552 RRIVDLHARNEESIERVYSIEDIQRYLLFARQ-FQPKITKEAEEFIVEQYRRLRQRDGSG 610
Query: 970 VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQI 1026
V KSS IT RQLE+LIRLSE+ ARM S V + +EA +L+ ++ ++
Sbjct: 611 VAKSSWR------ITVRQLESLIRLSESMARMHCSDEVQPKHVKEAFRLLSKSIIRV 661
Score = 131 bits (325), Expect = 6e-29
Identities = 106/383 (27%), Positives = 173/383 (44%), Gaps = 68/383 (17%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-IAINWMHLNSFDPELAEEVLEN----- 63
FL F E + LY+ ++L I P+R+ +A+N+ + ++ +LA + E
Sbjct: 32 FLEFFEECKGKDGSNLYVSAAEEL--IRPERNTLAVNFTDIEYYNQQLATTIQEEYYRVY 89
Query: 64 PEECILAAEDAIQIILKEDIMREDVP---RIHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P C A Q+ ++P + F + P ++E+ + I L+++ G
Sbjct: 90 PHLCRAVRSFARQM--------GNIPANKEFYIAFSDFPARQKIRELSSAKIGTLLRISG 141
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSK 178
V R + P + S F+C DC + V QQ Y K + LD KS+
Sbjct: 142 QVVRTHPVHPELVSGTFLCMDCQSIVKDVEQQFRYTQPTICKNPVCANRRRFTLDTNKSR 201
Query: 179 FVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE------ 232
FV+FQ RIQ+ L G +PR ++ IL + V++AM GDR G L VV +
Sbjct: 202 FVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVESAMAGDRCDFTGTLIVVPDVSAFAA 261
Query: 233 -----------------KREKVPTFKK--VIEVNY----------------------IEP 251
E V K V +++Y E
Sbjct: 262 GDARMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFLACYVGATNPRFGGKDLREED 321
Query: 252 VSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRT 311
+ E + ++T +E +K+ E+++ K++ + S+ P I+G E+K+G+ L LFGGVP+T
Sbjct: 322 QTAESIKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGVLLMLFGGVPKT 381
Query: 312 LPDGTRLRGDIHVLLVGDPGVAK 334
+GT LRGDI+V +VGDP +K
Sbjct: 382 TMEGTSLRGDINVCIVGDPSTSK 404
>gb|AAC41267.1| (AF031139) zygotic DNA replication factor MCM6b [Xenopus laevis]
Length = 824
Score = 187 bits (470), Expect = 6e-46
Identities = 106/233 (45%), Positives = 152/233 (64%), Gaps = 3/233 (1%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVRDE + +V+EAGAL+LAD G IDE DKM+ KD+ IHEA+EQQTIS++KAG+
Sbjct: 431 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDTKDQVAIHEAMEQQTISITKAGV 490
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP GR++R K + + +NL +MSRFDL F+LVDE +E D I
Sbjct: 491 KATLNARTSILAAANPVGGRYDRAKSLKQNVNLSAPIMSRFDLFFILVDECNEVTDYAIT 550
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKS 973
R I+ + E + D +R+Y+ +A K P IS+E+ + I + Y ++R+ +
Sbjct: 551 RRIVDLHSRIEESIDRVYTLDEVRRYLLFA-KQFKPKISKESEDFIVEQYKRLRQ--RDG 607
Query: 974 SEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQI 1026
S IT RQLE++IRLSE ARM S V + +EA +L+ ++ ++
Sbjct: 608 SGVTKSAWRITVRQLESMIRLSEGMARMHCSDEVQPKHVKEAFRLLNKSIIRV 660
Score = 131 bits (327), Expect = 3e-29
Identities = 106/386 (27%), Positives = 175/386 (44%), Gaps = 56/386 (14%)
Query: 3 REEIIER----FLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-IAINWMHLNSFDPELA 57
++E+ E+ F FL E+ E Y ++L I P+R+ + ++++ L F+ +LA
Sbjct: 20 KDEVAEKCQKLFQDFLEEFRGSDGELKYQSDAEEL--IRPERNTLLVSFVDLEQFNQQLA 77
Query: 58 EEVLENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQ 117
+ E A++ ++ + F LP ++E+ I L++
Sbjct: 78 TTIQEEFYRVYPYLCRAVKAFARDHGNIPQNKEFYVAFQELPTRHKIRELTTPRIGSLLR 137
Query: 118 VEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQLDVE 175
+ G V R + P + S F+C DC + V QQ Y + K LD
Sbjct: 138 ISGQVVRTHPVHPELVSGTFLCLDCQTLVRDVEQQFKYTQPSICRNPVCANRKRFMLDTN 197
Query: 176 KSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE--- 232
KS+FV+FQ RIQ+ L G +PR ++ IL + V++ GDR G L VV +
Sbjct: 198 KSRFVDFQKVRIQETQAELPRGSIPRSVEVILRAEAVESCQAGDRCDFTGSLIVVPDISQ 257
Query: 233 --------------------KREKVP----------TFKKVIEVNYIEPVS-----KEIE 257
+ E V ++K V Y+ P + K++
Sbjct: 258 LSTPGVRAETSSRVGGREGYEAEGVQGLRALGVRDLSYKLVFLACYVCPTNPRFGGKDLH 317
Query: 258 ELEITPE---------EEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGV 308
E ++T E E +K+ E+++ K++ + S+ P ++G EVK+GI L LFGGV
Sbjct: 318 EEDMTAESIKNQMSVKEWEKVFEMSQDKNLYHNLCTSLFPTVHGNDEVKRGILLMLFGGV 377
Query: 309 PRTLPDGTRLRGDIHVLLVGDPGVAK 334
P++ +GT LRGDI+V +VGDP AK
Sbjct: 378 PKSTMEGTSLRGDINVCVVGDPSTAK 403
>gi|6678832 mini chromosome maintenance deficient 6 (S. cerevisiae) [Mus
musculus] >gi|2497825|sp|P97311|MCM6_MOUSE DNA
REPLICATION LICENSING FACTOR MCM6 (MIS5 HOMOLOG)
>gi|1498166|dbj|BAA13159.1| (D86726) mMIS5 [Mus musculus]
Length = 821
Score = 186 bits (467), Expect = 1e-45
Identities = 108/237 (45%), Positives = 155/237 (64%), Gaps = 11/237 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVRDE + +V+EAGAL+LAD G IDE DKM+ +D+ IHEA+EQQTIS++KAG+
Sbjct: 430 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGV 489
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP G ++R K + + INL +MSRFDL F+LVDE +E D IA
Sbjct: 490 KATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIA 549
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK----S 969
R I+ + E + D +R+Y+ +AR+ P IS+E+ + I + Y ++R+
Sbjct: 550 RRIVDLHSRIEESIDRVYSLDDIRRYLLFARQ-FKPKISKESEDFIVEQYKRLRQRDGSG 608
Query: 970 VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQI 1026
V KSS IT RQLE++IRLSE+ ARM V + +EA +L+ ++ ++
Sbjct: 609 VTKSSWR------ITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRV 659
Score = 136 bits (340), Expect = 1e-30
Identities = 111/389 (28%), Positives = 182/389 (46%), Gaps = 62/389 (15%)
Query: 3 REEIIER----FLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-IAINWMHLNSFDPELA 57
R+E+ E+ FL FL E+ E Y+ ++L I P+R+ + +++ L F+ +L+
Sbjct: 19 RDEVAEKCQKLFLDFLEEFQGSDGEIKYLQFAEEL--IRPERNTLVVSFADLEQFNQQLS 76
Query: 58 EEVLENPEECILAAEDAIQIILKEDIMREDVP---RIHARFYNLPKTLMVKEIGAEHINK 114
+ E A++ +K+ R+++P + F +LP ++E+ + I
Sbjct: 77 TTIQEEFYRVYPYLCRALKTFVKD---RKEIPFAKDFYVAFQDLPTRHKIRELTSSRIGL 133
Query: 115 LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQL 172
L ++ G V R + P + S F+C DC + V QQ Y + K L
Sbjct: 134 LTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQFKYTQPNICRNPVCANRKRFLL 193
Query: 173 DVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV-- 230
D KS+FV+FQ RIQ+ L G +PR ++ IL + V++A GDR G L VV
Sbjct: 194 DTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPD 253
Query: 231 ----------QEKREKVP---------------------TFKKVIEVNYIEPVS-----K 254
E +V +++ V ++ P + K
Sbjct: 254 VSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGK 313
Query: 255 EIEELEITPE---------EEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALF 305
E+ + E T E E +K+ E+++ K++ + S+ P I+G EVK+G+ L LF
Sbjct: 314 ELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLF 373
Query: 306 GGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
GGVP+T +GT LRGDI+V +VGDP AK
Sbjct: 374 GGVPKTTGEGTSLRGDINVCIVGDPSTAK 402
>gi|7427519 minichromosome maintenance deficient (mis5, S. pombe) 6; Mis5 [Homo
sapiens] >gi|2497824|sp|Q14566|MCM6_HUMAN DNA REPLICATION
LICENSING FACTOR MCM6 (P105MCM)
>gi|1688042|dbj|BAA12699.1| (D84557) HsMcm6 [Homo
sapiens]
Length = 821
Score = 186 bits (467), Expect = 1e-45
Identities = 113/258 (43%), Positives = 162/258 (61%), Gaps = 13/258 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVRDE + +V+EAGAL+LAD G IDE DKM+ +D+ IHEA+EQQTIS++KAG+
Sbjct: 430 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGV 489
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP G ++R K + + INL +MSRFDL F+LVDE +E D IA
Sbjct: 490 KATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIA 549
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK----S 969
R I+ + E + D +R+Y+ +AR+ P IS+E+ + I + Y +R+
Sbjct: 550 RRIVDLHSRIEESIDRVYSLDDIRRYLLFARQ-FKPKISKESEDFIVEQYKHLRQRDGSG 608
Query: 970 VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD 1029
V KSS IT RQLE++IRLSEA ARM V + +EA +L+ ++ ++
Sbjct: 609 VTKSSWR------ITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETP 662
Query: 1030 ETG--QIDVTILEVGQSA 1045
+ Q + +EV + A
Sbjct: 663 DVNLDQEEEIQMEVDEGA 680
Score = 134 bits (335), Expect = 4e-30
Identities = 109/389 (28%), Positives = 181/389 (46%), Gaps = 62/389 (15%)
Query: 3 REEIIER----FLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-IAINWMHLNSFDPELA 57
R+E+ E+ FL FL E+ E Y+ ++L I P+R+ + ++++ L F+ +L+
Sbjct: 19 RDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEEL--IRPERNTLVVSFVDLEQFNQQLS 76
Query: 58 EEVLENPEECILAAEDAIQIILKEDIMREDVPR---IHARFYNLPKTLMVKEIGAEHINK 114
+ E A++ +K+ R+++P + F +LP ++E+ + I
Sbjct: 77 TTIQEEFYRVYPYLCRALKTFVKD---RKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGL 133
Query: 115 LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQL 172
L ++ G V R + P + S F+C DC + V QQ Y + + L
Sbjct: 134 LTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLL 193
Query: 173 DVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE 232
D KS+FV+FQ RIQ+ L G +PR ++ IL + V++A GD+ G L VV +
Sbjct: 194 DTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPD 253
Query: 233 KRE------KVPTFKKVIEVNYIEPV--------------------------------SK 254
+ + T +V V+ E K
Sbjct: 254 VSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGK 313
Query: 255 EIEELEITPE---------EEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALF 305
E+ + E T E E +K+ E+++ K++ + S+ P I+G EVK+G+ L LF
Sbjct: 314 ELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLF 373
Query: 306 GGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
GGVP+T +GT LRGDI+V +VGDP AK
Sbjct: 374 GGVPKTTGEGTSLRGDINVCIVGDPSTAK 402
>gb|AAD32858.1|AF124744_1 (AF124744) DNA replication factor MCM6 [Drosophila melanogaster]
>gi|7290738|gb|AAF46184.1| (AE003438) Mcm6 gene product
[Drosophila melanogaster]
Length = 817
Score = 186 bits (467), Expect = 1e-45
Identities = 132/377 (35%), Positives = 205/377 (54%), Gaps = 26/377 (6%)
Query: 654 AKLLKFYGVELNLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLV 713
A +F G +L ++E D +++ + K I E + DR Y +L+
Sbjct: 297 ATTARFGGTDLPMSEVTAEDMKKQMTDAEWHK--------IYEMSK-----DRNLYQNLI 343
Query: 714 EML-SSMEGELKEEVMLLLSDVGDIHEVIQERLKEIGKI---LESDASWERIAEVEEVVR 769
L S+ G + + +LL G + + E+ G I + D S + +++V
Sbjct: 344 SSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQV-S 402
Query: 770 DGHVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKM 829
D + G S A TAAVVRDE + +V+EAGAL+LAD G IDE DKM
Sbjct: 403 DFSPRAIYTSGKASSAAG-----LTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKM 457
Query: 830 NDKDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPT 889
+ +D+ IHEA+EQQTIS+++AG+ ATLNART+++AAANP GR++R K + + I L
Sbjct: 458 DQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAP 517
Query: 890 LMSRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHP 949
+MSRFDL F+LVDE +E +D IAR I+ + E V + + +Y+ +AR+ P
Sbjct: 518 IMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLRYVTFARQ-FKP 576
Query: 950 VISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTR 1009
VIS+EA + + Y +R+ + + IT RQLE++IRLSEA A++ S V
Sbjct: 577 VISQEAGHMLVENYGHLRQ--RDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLE 634
Query: 1010 EDAREAIKLMEYTLRQI 1026
+EA +L+ ++ ++
Sbjct: 635 RHVKEAFRLLNKSIIRV 651
Score = 136 bits (338), Expect = 2e-30
Identities = 107/408 (26%), Positives = 178/408 (43%), Gaps = 55/408 (13%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
F FL E+ E+GE + + L + ++ +++ + +D LA ++E
Sbjct: 25 FQDFLEEFKEDGE--IKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYP 82
Query: 70 AAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIK 129
++ +K+ I + + F +P V+++ I LI++ G V R +
Sbjct: 83 FLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVH 142
Query: 130 PFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFVNFQMFRI 187
P + S VF+C DC E+ V QQ + + K LDVEKS F++FQ RI
Sbjct: 143 PELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRI 202
Query: 188 QDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE---------KREKVP 238
Q+ L G +PR ++ IL ++V+T GDR G L VV + + E
Sbjct: 203 QETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSS 262
Query: 239 TFKK--------------VIEVNY----------------------IEPVSKEIEELEIT 262
K + E+NY + V+ E + ++T
Sbjct: 263 RHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMT 322
Query: 263 PEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDI 322
E KI E++K +++ ++ S+ P+IYG EVK+GI L FGGV +T + T LRGDI
Sbjct: 323 DAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDI 382
Query: 323 HVLLVGDPGVAK------CVDYETEVVLGNGERKKIGEIVERAIEEAE 364
+V +VGDP AK D+ + +G+ + + + E
Sbjct: 383 NVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEE 430
>gi|11429381 minichromosome maintenance deficient (mis5, S. pombe) 6 [Homo
sapiens]
Length = 711
Score = 186 bits (467), Expect = 1e-45
Identities = 113/258 (43%), Positives = 162/258 (61%), Gaps = 13/258 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVRDE + +V+EAGAL+LAD G IDE DKM+ +D+ IHEA+EQQTIS++KAG+
Sbjct: 320 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGV 379
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP G ++R K + + INL +MSRFDL F+LVDE +E D IA
Sbjct: 380 KATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIA 439
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK----S 969
R I+ + E + D +R+Y+ +AR+ P IS+E+ + I + Y +R+
Sbjct: 440 RRIVDLHSRIEESIDRVYSLDDIRRYLLFARQ-FKPKISKESEDFIVEQYKHLRQRDGSG 498
Query: 970 VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD 1029
V KSS IT RQLE++IRLSEA ARM V + +EA +L+ ++ ++
Sbjct: 499 VTKSSWR------ITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETP 552
Query: 1030 ETG--QIDVTILEVGQSA 1045
+ Q + +EV + A
Sbjct: 553 DVNLDQEEEIQMEVDEGA 570
Score = 108 bits (266), Expect = 5e-22
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 49/267 (18%)
Query: 117 QVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQLDV 174
++ G V R + P + S F+C DC + V QQ Y + + LD
Sbjct: 26 RISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDT 85
Query: 175 EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKR 234
KS+FV+FQ RIQ+ L G +PR ++ IL + V++A GD+ G L VV +
Sbjct: 86 NKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVS 145
Query: 235 E------KVPTFKKVIEVNYIEPVS--------------------------------KEI 256
+ + T +V V+ E KE+
Sbjct: 146 KLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKEL 205
Query: 257 EELEITPE---------EEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGG 307
+ E T E E +K+ E+++ K++ + S+ P I+G EVK+G+ L LFGG
Sbjct: 206 RDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGG 265
Query: 308 VPRTLPDGTRLRGDIHVLLVGDPGVAK 334
VP+T +GT LRGDI+V +VGDP AK
Sbjct: 266 VPKTTGEGTSLRGDINVCIVGDPSTAK 292
>sp|P40377|CC19_SCHPO CELL DIVISION CONTROL PROTEIN 19 >gi|542209|pir||B48723 replication
licensing factor MCM2 homolog nda1 - fission yeast
(Schizosaccharomyces pombe) >gi|476336|gb|AAC48930.1|
(U08048) Cdc19p [Schizosaccharomyces pombe]
>gi|545213|gb|AAC60569.1| (S68468) MCM2 homolog=nda1+
[Schizosaccharomyces pombe, nda1-376, Peptide, 830 aa]
>gi|6066722|emb|CAB58403.1| (AL121863) cell division
control protein 19 [Schizosaccharomyces pombe]
>gi|1093054|prf||2102323A replication protein
[Schizosaccharomyces pombe]
Length = 830
Score = 185 bits (466), Expect = 2e-45
Identities = 116/348 (33%), Positives = 182/348 (51%), Gaps = 20/348 (5%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R I F FL EY +E +Y +I+ L + + S+ +N+ HL P LA +
Sbjct: 197 RRTIAREFKNFLLEYTDENGTSVYGNRIRTLGEVNAE-SLMVNYAHLGESKPILAYFLAN 255
Query: 63 NPEECILAAEDAIQIILKEDIMR-EDVPRIHA----RFYNLPKTLMVKEIGAEHINKLIQ 117
P + ++ L+ ++ D RIH+ R NLP ++++ H+N L++
Sbjct: 256 APAPIFRIFD---RVALEATLLHYPDYERIHSDIHVRITNLPTCFTLRDLRQSHLNCLVR 312
Query: 118 VEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEK 176
V GVVTR T + P + F C CG + + V + C C S+ ++ E+
Sbjct: 313 VSGVVTRRTGLFPQLKYIRFTCTKCGATLGPFFQDSSVEVKISFCHNCSSRGPFVINSER 372
Query: 177 SKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILR----VVQE 232
+ + N+Q +Q+ P T+ G++PR + ILL D+VD A PG+ + V GI R
Sbjct: 373 TVYNNYQRITLQESPGTVPSGRLPRHREVILLADLVDVAKPGEEIDVTGIYRNNFDASLN 432
Query: 233 KREKVPTFKKVIEVNYIEPVS------KEIEELEITPEEEQKIRELAKRKDIVDAIVDSI 286
+ P F +IE N+I + + +T +EE++IR LAK DI + I+ S+
Sbjct: 433 TKNGFPVFATIIEANHISQLDGSGNTDDDFSLSRLTDDEEREIRALAKSPDIHNRIIASM 492
Query: 287 APAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
AP+IYG+R +K IA ALFGGVP+ + ++RGDI+VLL+GDPG AK
Sbjct: 493 APSIYGHRSIKTAIAAALFGGVPKNINGKHKIRGDINVLLLGDPGTAK 540
Score = 180 bits (451), Expect = 1e-43
Identities = 123/354 (34%), Positives = 185/354 (51%), Gaps = 33/354 (9%)
Query: 687 LSDVTIEIPEKLRRFIKCDRVRYVDLVEMLSSMEGELKEEVMLLLSDVGDIHEVIQERLK 746
LS +T + ++R K + + M S+ G + + + G + + I + K
Sbjct: 464 LSRLTDDEEREIRALAKSPDIHNRIIASMAPSIYGHRSIKTAIAAALFGGVPKNINGKHK 523
Query: 747 ---EIGKILESDASWERIAEVEEVVRDGH-VYDLTVEGSHSFIANGFVVHNTAAVVRDEF 802
+I +L D + ++ V + H T +G+ + V TA+V +D
Sbjct: 524 IRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFATGQGASA-------VGLTASVRKDPI 576
Query: 803 TGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGITATLNARTT 862
T W LE GALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI TL AR T
Sbjct: 577 TNEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCT 636
Query: 863 VIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIAR-------- 914
+IAAANP GR+N ++ + L ++SRFD++ V+ D + +ID ++A
Sbjct: 637 IIAAANPIGGRYNTTIPFNQNVELTEPILSRFDILQVVKDTVNPEIDEQLANFVVSSHIR 696
Query: 915 ---------HILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVK 965
+L+ E+ + IP DLLRKYI +AR+ V P + + E+I + Y
Sbjct: 697 SHPAFDPNMDVLKKVPTETGIDAKPIPQDLLRKYIHFAREKVFPRLQQMDEEKISRLYSD 756
Query: 966 MRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLM 1019
MR+ + PIT R LE+ IRLSEA A+M+LS V +AI+++
Sbjct: 757 MRRESLATGS-----YPITVRHLESAIRLSEAFAKMQLSEFVRPSHIDKAIQVI 805
>sp|Q62724|MCM6_RAT DNA REPLICATION LICENSING FACTOR MCM6 (INTESTINAL DNA REPLICATION
PROTEIN) >gi|7513992|pir||T10753 intestinal DNA
replication protein - rat (fragment)
>gi|3169699|gb|AAC18424.1| (U17565) intestinal DNA
replication protein [Rattus norvegicus]
Length = 507
Score = 185 bits (466), Expect = 2e-45
Identities = 107/237 (45%), Positives = 155/237 (65%), Gaps = 11/237 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVRDE + +V+EAGAL+LAD G IDE DKM+ +D+ IHEA+EQQTIS++KAG+
Sbjct: 116 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGV 175
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNART+++AAANP G ++R K + + INL +MSRFDL F+LVDE +E D IA
Sbjct: 176 KATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIA 235
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK----S 969
R I+ + E + D +R+Y+ +AR+ P IS+E+ + I + Y ++R+
Sbjct: 236 RRIVDLHSRIEESIDRVYSLDDIRRYLLFARQ-FKPKISKESEDFIVEQYKRLRQRDGSG 294
Query: 970 VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQI 1026
+ KSS IT RQLE++IRLSE+ ARM V + +EA +L+ ++ ++
Sbjct: 295 ITKSSWR------ITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRV 345
Score = 74.9 bits (181), Expect = 4e-12
Identities = 34/75 (45%), Positives = 54/75 (71%)
Query: 260 EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLR 319
++T +E +K+ E+++ +++ + S+ P I+G EVK+G+ L LFGGVP+T +GT LR
Sbjct: 14 QMTVKEWEKVFEMSQDQNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLR 73
Query: 320 GDIHVLLVGDPGVAK 334
GDI+V +VGDP AK
Sbjct: 74 GDINVCIVGDPSTAK 88
>gb|AAD48445.1|AF164200_1 (AF164200) putative DNA replication protein CDC47 [Trypanosoma
brucei]
Length = 731
Score = 185 bits (466), Expect = 2e-45
Identities = 113/291 (38%), Positives = 174/291 (58%), Gaps = 24/291 (8%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV RD +TG +LE GALVL+D G IDE DKM+D DR+ +HE +EQQ +S++KAGI
Sbjct: 418 TAAVTRDTYTGEVMLEGGALVLSDRGICCIDEFDKMDDSDRTALHEVMEQQMVSIAKAGI 477
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+LNART+++AAANPK GR+ R SE +NLPP L+SRFD++++L+DE + + D+E++
Sbjct: 478 ITSLNARTSILAAANPKYGRWRRNLTPSENVNLPPALLSRFDVLWLLLDESNRERDAELS 537
Query: 914 RHILRVR-----------RGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKY 962
H+ V G + + D L+ Y+ A+K +HP++ A + I
Sbjct: 538 MHVTYVHLHGVAPGTVSDNGFYGLSSDYFGKDFLQAYVGEAKK-IHPIVDSSAAKVISDI 596
Query: 963 YVKMR-KSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEY 1021
Y +MR +SV+ ++ +TAR L ++IRLS+A AR+R S V D REA +L++
Sbjct: 597 YCEMRAQSVRHTN-------VVTARTLLSIIRLSQACARLRFSDRVVEADVREAGRLLDC 649
Query: 1022 T--LRQIAVDETGQIDVTILE--VGQSARKLSKVERILDIIEKLEGTSEKG 1068
+ Q VD G+ VT + + + ++L++ +D+ E KG
Sbjct: 650 SKISLQERVDTGGRRMVTTSDAAIFSTIKELARSRGSIDLAEVRPALMIKG 700
Score = 83.9 bits (204), Expect = 9e-15
Identities = 78/302 (25%), Positives = 135/302 (43%), Gaps = 28/302 (9%)
Query: 58 EEVLENPEECILAA---EDAIQ-IILKEDIMREDVPRIHARFYNL--------PKTLMVK 105
EEV +E I A ED I +IL+ + +P + R Y L + + ++
Sbjct: 92 EEVYRVVDEIIPEAYFEEDMIDHLILEAQTAGQHLPPLLTRRYELVVMPLTSFSEPVPLR 151
Query: 106 EIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCE-- 163
++ I L+ + G+ T ++P +S V VC+ C E QQ + + C+
Sbjct: 152 QLKGGLIGTLVVLRGICIAATAVRPKLSMLVSVCEVCA-ETTFQQVIGDRLTPLMVCQSQ 210
Query: 164 KCGSKN----VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGD 219
+C N + + SKF Q R+Q+ P+ + G +PR I I + A PG
Sbjct: 211 RCRLNNTVGRLLPQYKASKFTKHQELRLQELPQYVPRGAIPRTIRVICEGEQTRIATPGQ 270
Query: 220 RVVVVGILRVVQEKREKVPTF------KKVIEVNYIEPVSKEIEE-LEITPEEEQKIREL 272
V VVG + F K + IE + +E + + +++
Sbjct: 271 VVKVVGTYCPDPSTGQGHEAFRASTMVKTLFRALRIELERRSYQEAADDLKIQVDNVKQH 330
Query: 273 AKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGV 332
++ +++ + S+AP I+G +VKK + L GG ++ +G R+R D ++ L+GDPGV
Sbjct: 331 PDKEVVIEKLTRSVAPEIWGMEDVKKALLCLLVGG--SSIANGIRIRSDTNICLMGDPGV 388
Query: 333 AK 334
AK
Sbjct: 389 AK 390
>pir||T26498 hypothetical protein Y17G7B.5 - Caenorhabditis elegans
>gi|3947600|emb|CAA19452.1| (AL023828) contains
similarity to Pfam domain: PF00493 (MCM2/3/5 family),
Score=901.3, E-value=9.2e-268, N=1~cDNA EST yk96b11.5
comes from this gene~cDNA EST EMBL:T02370 comes from this
gene~cDNA EST yk96b11.3 comes from this gene~cDNA EST
yk49h9.3 com>
Length = 881
Score = 185 bits (465), Expect = 2e-45
Identities = 103/246 (41%), Positives = 147/246 (58%), Gaps = 25/246 (10%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R T W LEAGA+VLAD G LIDE DKM+D+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 532 TAYVQRHPVTREWTLEAGAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGI 591
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L+AR TVIAA+NP GR+N + +E ++L ++SRFD++ V+ D D D +A
Sbjct: 592 VTSLHARCTVIAASNPIGGRYNPTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLA 651
Query: 914 RHIL---RVRRGESEVVTPK-----------------IPHDLLRKYIAYARKNVHPVISE 953
+ ++ R +++ + + IP DLLRKYI YAR+ HP + E
Sbjct: 652 KFVVGNHRTHHPDAKKIVKEGDELEEDQMDERTGVRLIPQDLLRKYIIYAREKCHPTLPE 711
Query: 954 EAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAR 1013
+ E+ + +MRK + + IT R +E++IRLSEAHA++ L V ED
Sbjct: 712 QHSEKFSNIFAQMRKESMATGS-----VAITVRHVESMIRLSEAHAKLHLRSYVNDEDCA 766
Query: 1014 EAIKLM 1019
AI++M
Sbjct: 767 AAIRVM 772
Score = 151 bits (377), Expect = 5e-35
Identities = 111/343 (32%), Positives = 175/343 (50%), Gaps = 16/343 (4%)
Query: 4 EEIIERFLRFLREYAEEG-EEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPE--LAEEV 60
+EI RF FLR + E G ++ YI IK + A + S+ +++ L+ + E ++ +
Sbjct: 166 KEIERRFKNFLRSFHEPGNKQTKYIQMIKSMAADN-RESLEVSFTDLSDDNGEQNISYFL 224
Query: 61 LENPEECILAAEDAIQIILKE--DIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQV 118
E P E + + A ++ I R LP ++ + H+N LI+
Sbjct: 225 PEAPNEMLAIMDRAATEVVMNMYPFYSRVCNEIKVRISQLPVEEDIRMLRQVHLNMLIRT 284
Query: 119 EGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKN-VQLDVE 175
GVVT + I P ++ + C CG+ + VQQ E V C C K +L+VE
Sbjct: 285 AGVVTIASGILPQLAVVKYDCVACGYLLGPFVQQNDEE--VRPTICPSCQGKGPFELNVE 342
Query: 176 KSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEK-- 233
+ + N+Q +Q+ P + G++PR D ILL D+ D+ PGD + V G+ +
Sbjct: 343 NTVYHNYQRITMQESPNKVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYTNNFDGSL 402
Query: 234 --REKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIY 291
++ P F +I N+I K + ++T E+ + IREL++ +I + SIAP+IY
Sbjct: 403 NYKQGFPVFNTLIHANHITNKDKMASD-QLTDEDIKAIRELSQDPNISQRVFSSIAPSIY 461
Query: 292 GYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
G+ +VK+ IALALF G + RLRGDI+VLL GDPG AK
Sbjct: 462 GHDDVKRAIALALFRGEAKNPGAKHRLRGDINVLLCGDPGTAK 504
>dbj|BAA34732.1| (AB010108) MCM6 [Drosophila melanogaster]
Length = 817
Score = 185 bits (465), Expect = 2e-45
Identities = 132/377 (35%), Positives = 205/377 (54%), Gaps = 26/377 (6%)
Query: 654 AKLLKFYGVELNLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKCDRVRYVDLV 713
A +F G +L ++E D +++ + K I E + DR Y +L+
Sbjct: 297 ATTARFGGTDLPMSEVTAEDMKKQMTDAEWHK--------IYEMSK-----DRNLYQNLI 343
Query: 714 EML-SSMEGELKEEVMLLLSDVGDIHEVIQERLKEIGKI---LESDASWERIAEVEEVVR 769
L S+ G + + +LL G + + E+ G I + D S + +++V
Sbjct: 344 SSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDINVCIVGDPSTAKSQFLKQV-S 402
Query: 770 DGHVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKM 829
D + G S A TAAVVRDE + +V+EAGAL+LAD G IDE DKM
Sbjct: 403 DFSPRAIYTSGKASSAAG-----LTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKM 457
Query: 830 NDKDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPT 889
+ +D+ IHEA+EQQTIS+++AG+ ATLNART+++AAANP GR++R K + + I L
Sbjct: 458 DQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAP 517
Query: 890 LMSRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHP 949
+MSRFDL F+LVDE +E +D IAR I+ + E V + + +Y+ +AR+ P
Sbjct: 518 IMSRFDLFFILVDECNEVVDYAIARKIVDLHSKIEESVERAYTREEVLRYVTFARQ-FKP 576
Query: 950 VISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTR 1009
VIS+EA + + Y +R+ + + IT RQLE++IRLSEA A++ S V
Sbjct: 577 VISQEAGHMLVENYGHLRQ--RDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLE 634
Query: 1010 EDAREAIKLMEYTLRQI 1026
+EA +L+ ++ ++
Sbjct: 635 RHVKEAFRLLNKSIIRV 651
Score = 136 bits (338), Expect = 2e-30
Identities = 107/408 (26%), Positives = 178/408 (43%), Gaps = 55/408 (13%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
F FL E+ E+GE + + L + ++ +++ + +D LA ++E
Sbjct: 25 FQDFLEEFKEDGE--IKYTRPAASLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHIYP 82
Query: 70 AAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIK 129
++ +K+ I + + F +P V+++ I LI++ G V R +
Sbjct: 83 FLCQSVSNYVKDRIGLKTQKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVH 142
Query: 130 PFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFVNFQMFRI 187
P + S VF+C DC E+ V QQ + + K LDVEKS F++FQ RI
Sbjct: 143 PELVSGVFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRI 202
Query: 188 QDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE---------KREKVP 238
Q+ L G +PR ++ IL ++V+T GDR G L VV + + E
Sbjct: 203 QETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSS 262
Query: 239 TFKK--------------VIEVNY----------------------IEPVSKEIEELEIT 262
K + E+NY + V+ E + ++T
Sbjct: 263 RHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMT 322
Query: 263 PEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDI 322
E KI E++K +++ ++ S+ P+IYG EVK+GI L FGGV +T + T LRGDI
Sbjct: 323 DAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLRGDI 382
Query: 323 HVLLVGDPGVAK------CVDYETEVVLGNGERKKIGEIVERAIEEAE 364
+V +VGDP AK D+ + +G+ + + + E
Sbjct: 383 NVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEE 430
>gb|AAC50766.1| (U46838) p105MCM [Homo sapiens]
Length = 821
Score = 184 bits (463), Expect = 4e-45
Identities = 112/258 (43%), Positives = 161/258 (61%), Gaps = 13/258 (5%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVVRDE + +V+EAGAL+LAD G IDE DKM+ +D+ IHEA+EQQTIS++KAG+
Sbjct: 430 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGV 489
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLN RT+++AAANP G ++R K + + INL +MSRFDL F+LVDE +E D IA
Sbjct: 490 KATLNTRTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIA 549
Query: 914 RHILRVRRGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK----S 969
R I+ + E + D +R+Y+ +AR+ P IS+E+ + I + Y +R+
Sbjct: 550 RRIVDLHSRIEESIDRVYSLDDIRRYLLFARQ-FKPKISKESEDFIVEQYKHLRQRDGSG 608
Query: 970 VKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVD 1029
V KSS IT RQLE++IRLSEA ARM V + +EA +L+ ++ ++
Sbjct: 609 VTKSSWR------ITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETP 662
Query: 1030 ETG--QIDVTILEVGQSA 1045
+ Q + +EV + A
Sbjct: 663 DVNLDQEEEIQMEVDEGA 680
Score = 116 bits (288), Expect = 1e-24
Identities = 103/389 (26%), Positives = 174/389 (44%), Gaps = 62/389 (15%)
Query: 3 REEIIER----FLRFLREYAEEGEEPLYIGKIKDLLAITPKRS-IAINWMHLNSFDPELA 57
R+E+ E+ FL FL E+ E Y+ ++L I P+R+ + ++++ L F+ +L+
Sbjct: 19 RDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEEL--IRPERNTLVVSFVDLEQFNQQLS 76
Query: 58 EEVLENPEECILAAEDAIQIILKEDIMREDVPR---IHARFYNLPKTLMVKEIGAEHINK 114
+ E A++ +K+ R+++P + F +LP ++E+ + I
Sbjct: 77 TTIQEEFYRVYPYLCRALKTFVKD---RKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGL 133
Query: 115 LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEM--VVQQKPYEGFVAVKKCEKCGSKNVQL 172
L ++ G V R + P + S F+C DC + V QQ Y + + L
Sbjct: 134 LTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLL 193
Query: 173 DVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE 232
D KS+FV+FQ RIQ+ L G +PR ++ IL + V++A GD+ G L VV +
Sbjct: 194 DTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPD 253
Query: 233 KRE------KVPTFKKVIEVNYIEPV--------------------------------SK 254
+ + T +V V+ E K
Sbjct: 254 VSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGK 313
Query: 255 EIEELEITPE---------EEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALF 305
E+ + E T E E +K+ E+++ K++ + S+ P I+G EVK+G+ L LF
Sbjct: 314 ELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLF 373
Query: 306 GGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
GGV + GDI+V +VGDP AK
Sbjct: 374 GGVSKDNRRRDLSSGDINVCIVGDPSTAK 402
>emb|CAB55370.1| (AL117260) DNA replication licensing factor (CDC47 homolog)
[Leishmania major]
Length = 725
Score = 183 bits (459), Expect = 1e-44
Identities = 103/238 (43%), Positives = 142/238 (59%), Gaps = 18/238 (7%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D TG +LE GALVL+D G IDE DKM+D DR+ +HE +EQQ +S++KAGI
Sbjct: 412 TAAVTHDTHTGEVMLEGGALVLSDKGVCCIDEFDKMDDSDRTALHEVMEQQMVSIAKAGI 471
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+LNART+++AAANPK GR+ R +E +NLPP L+SRFDL+++L+DE + D+E++
Sbjct: 472 ITSLNARTSILAAANPKFGRWKRNATPTENVNLPPALLSRFDLLWLLLDESSRERDAELS 531
Query: 914 RHILRVR-----------RGESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKY 962
H+ V G T D LR Y+ K +HP + A + I
Sbjct: 532 MHVTHVHLHGVAPGTVADDGVRGTTTEYFGRDFLRAYVGEV-KRIHPYVDPGAAKAISDI 590
Query: 963 YVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLME 1020
Y +MR + S +TAR L +LIRLS+A AR+R S V ED REA +L++
Sbjct: 591 YCEMRAQSARHSN------VVTARTLLSLIRLSQACARLRFSERVLEEDVREAGRLLD 642
Score = 97.9 bits (240), Expect = 5e-19
Identities = 74/280 (26%), Positives = 133/280 (47%), Gaps = 24/280 (8%)
Query: 76 QIILKEDIMREDVPRIHARFYNLP--------KTLMVKEIGAEHINKLIQVEGVVTRVTE 127
Q+I++ + +++P + R Y L + ++E+ I L + G+ T
Sbjct: 108 QLIMEARMSGQELPALLTRRYELKIHPLSEDSVPIPLRELKGGKIGTLTVLRGICIAATA 167
Query: 128 IKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCE--KCGSKN----VQLDVEKSKFVN 181
++P +S V VC+ C E QQ + ++ C+ +C N + + SKF+
Sbjct: 168 VRPKLSMLVSVCEVCA-ETTFQQVIGDRLTPLQVCQSQRCKLNNAVGRLLAQNKASKFMK 226
Query: 182 FQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTF- 240
+Q R+Q+ PE + G +PR I + + A PG V + G+ + F
Sbjct: 227 YQELRVQELPEDVPRGAIPRTIRVVCEGEQTRIATPGQVVRITGVYCPDPSTGQGHEAFR 286
Query: 241 -----KKVIEVNYIEPVSKEIEEL-EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYR 294
K + + +IE + +E E + + IR+ R+ +++ + SIAP I+G
Sbjct: 287 ASTMVKTLYKAIHIELEKRSYQEAAEDMRAQVEDIRDYPDREAVIEKLTRSIAPEIWGME 346
Query: 295 EVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+VKK + L GG ++ +G R+R DI++L +GDPGVAK
Sbjct: 347 DVKKALLCQLVGG--SSIANGIRIRSDINILFMGDPGVAK 384
>sp|P34647|MCM6_CAEEL DNA REPLICATION LICENSING FACTOR MCM6 HOMOLOG
>gi|3879078|emb|CAA82357.1| (Z29095) similar to Mcm2 and
Mcm3: yeast ARS related proteins, contains similarity to
Pfam domain: PF00493 (MCM2/3/5 family), Score=1018.5,
E-value=4.8e-303, N=1~cDNA EST yk105h8.5 comes from this
gene; cDNA EST EMBL:M89289 comes from this gene~cDNA ES>
>gi|3881705|emb|CAA80191.1| (Z22181) similar to Mcm2 and
Mcm3: yeast ARS related proteins, contains similarity to
Pfam domain: PF00493 (MCM2/3/5 family), Score=1018.5,
E-value=4.8e-303, N=1~cDNA EST yk105h8.5 comes from this
gene; cDNA EST EMBL:M89289 comes from this gene~cDNA ES>
Length = 810
Score = 182 bits (456), Expect = 3e-44
Identities = 109/235 (46%), Positives = 151/235 (63%), Gaps = 5/235 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVV+DE + +V+EAGAL+LAD G IDE DKM+ KD+ IHEA+EQQTIS++KAG+
Sbjct: 431 TAAVVKDEESFEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGV 490
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNAR +++AAANP GR++R + + + + +MSRFDL FVLVDE +E D IA
Sbjct: 491 KATLNARASILAAANPVNGRYDRSRPLKYNVQMSAPIMSRFDLFFVLVDECNEVTDYAIA 550
Query: 914 RHILRVRRGESEVVTPKIPH--DLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
R IL R SE + D ++KYIA+AR P IS++A E + + Y K+R S
Sbjct: 551 RRILDNHRAISEHTERDSVYKIDDIKKYIAFAR-CFKPKISDKAAETLVREYKKLRMS-- 607
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQI 1026
S+ IT RQLE+L+RLSEA AR+ V E +A +L+ ++ ++
Sbjct: 608 DSNNAATSSWRITVRQLESLVRLSEALARLHCGKEVLVEHVEKAAELLNKSIVRV 662
Score = 143 bits (357), Expect = 1e-32
Identities = 113/393 (28%), Positives = 178/393 (44%), Gaps = 65/393 (16%)
Query: 2 DREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVL 61
D + F +FL+ + ++ E +Y +K+L+ K +I IN HL F LA +
Sbjct: 16 DGTRVQNEFSKFLKSFKDQKNEFIYKSAMKELVQ-PEKNTIFINMQHLYKFSNNLATTIE 74
Query: 62 ENP--------EECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHIN 113
E LA DA ++ + ++ +++ +NL V+E+ A+ +
Sbjct: 75 LQYYRVYPFMCEALHLATLDACDESERQQMFKK---QLYVSLFNLDAKTKVRELSADKVG 131
Query: 114 KLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN---V 170
L+++ G + R + P +S A FVC+DCG Q+ + + KC N
Sbjct: 132 GLVRIAGQIVRTHPVHPELSRACFVCEDCGVTTRDVQQQFR-YTQPTKCANPQCMNRTRF 190
Query: 171 QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV 230
LDV S FV+FQ RIQ+ L G +PR +D I+ ++V+T PGD+ +VG L V+
Sbjct: 191 SLDVNSSTFVDFQKIRIQETQAELPRGSIPRTVDVIVRGEMVETVQPGDKCDIVGTLIVI 250
Query: 231 -----------------------QEKREKVP----------TFKKVIEVNYIE------- 250
+K E + T+K +I+
Sbjct: 251 PDIAQLSTPGLRAETSNQNRGRATDKSEGITGLKALGVRDLTYKMAFLACHIQQTESLVG 310
Query: 251 -PVSKEIEELE-------ITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIAL 302
S +EE + ++ E+ +++++ K I IVDS+ P IYG EVK G+ L
Sbjct: 311 GDASGAVEETDYLDLWSKMSTEDRATLKKMSDDKKIEKNIVDSLFPNIYGNHEVKLGVLL 370
Query: 303 ALFGGVPRTLPD-GTRLRGDIHVLLVGDPGVAK 334
L GGV + D GT LRGDI+V LVGDP AK
Sbjct: 371 MLLGGVAKKSRDEGTSLRGDINVCLVGDPSTAK 403
>pir||S40933 probable replication licensing factor MCM6 - Caenorhabditis elegans
(fragment)
Length = 521
Score = 182 bits (456), Expect = 3e-44
Identities = 109/235 (46%), Positives = 151/235 (63%), Gaps = 5/235 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVV+DE + +V+EAGAL+LAD G IDE DKM+ KD+ IHEA+EQQTIS++KAG+
Sbjct: 142 TAAVVKDEESFEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGV 201
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
ATLNAR +++AAANP GR++R + + + + +MSRFDL FVLVDE +E D IA
Sbjct: 202 KATLNARASILAAANPVNGRYDRSRPLKYNVQMSAPIMSRFDLFFVLVDECNEVTDYAIA 261
Query: 914 RHILRVRRGESEVVTPKIPH--DLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVK 971
R IL R SE + D ++KYIA+AR P IS++A E + + Y K+R S
Sbjct: 262 RRILDNHRAISEHTERDSVYKIDDIKKYIAFAR-CFKPKISDKAAETLVREYKKLRMS-- 318
Query: 972 KSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQI 1026
S+ IT RQLE+L+RLSEA AR+ V E +A +L+ ++ ++
Sbjct: 319 DSNNAATSSWRITVRQLESLVRLSEALARLHCGKEVLVEHVEKAAELLNKSIVRV 373
>sp|P30666|MCM3_SCHPO MINICHROMOSOME MAINTENANCE PROTEIN 3 HOMOLOG >gi|7490536|pir||T41059
replication licensing factor MCM3 - fission yeast
(Schizosaccharomyces pombe) >gi|3139137|gb|AAC32263.1|
(AF063864) essential nuclear protein Mcm3p
[Schizosaccharomyces pombe] >gi|3560156|emb|CAA20668.1|
(AL031525) minichromosome maintenance protein 3 homolog
[Schizosaccharomyces pombe]
Length = 879
Score = 181 bits (454), Expect = 4e-44
Identities = 122/359 (33%), Positives = 179/359 (48%), Gaps = 80/359 (22%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR IHE +EQQT++++KAGI
Sbjct: 390 TAAVTTDKETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGI 449
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+LNAR +VIAAANP G+++ K + I LP +++SRFDL+F++ D+ D+K D ++
Sbjct: 450 HTSLNARCSVIAAANPIYGQYDIRKDPHQNIALPDSMLSRFDLLFIVTDDIDDKKDRALS 509
Query: 914 RHILRVRR----------------------------------GESEVVTP------KIPH 933
H+LR+ R E EV TP + H
Sbjct: 510 EHVLRMHRYLPPGVEPGTPVRDSLNSVLNVGATNAAGVSTENVEQEVETPVWETFSSLLH 569
Query: 934 -------------DLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKP 980
+ +RKYI YA+ +HP++++ E I Y +R + ++ +
Sbjct: 570 ANARTKKKELLNINFVRKYIQYAKSRIHPILNQATAEYITNIYCGLRNDDLQGNQR--RT 627
Query: 981 IPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILE 1040
P+TAR LE LIRLS AHA+ RLS +V +DA+ A K++ Y L E
Sbjct: 628 SPLTARTLETLIRLSTAHAKARLSSVVEVKDAKAAEKILRYAL--------------FRE 673
Query: 1041 VGQSARKLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEAREILEKLLEQG 1099
V + RK K +R+ E G + D + + IE+ E +++ G
Sbjct: 674 VVKPKRKKHKKQRL-----------EAGEEFDSEDDNSDDMDIEESEEEMDTNMVIDSG 721
Score = 145 bits (363), Expect = 2e-33
Identities = 109/364 (29%), Positives = 179/364 (48%), Gaps = 41/364 (11%)
Query: 4 EEIIERFLRFLREYAEEGEEP----LYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEE 59
+E+ + +R +EY E + LY I +L + +R I +N L ++ ELA+
Sbjct: 7 DEVFKDRVRIFQEYLEHDTDDANVTLYQEAILRMLNMGQRRLI-VNIDELRDYNRELADG 65
Query: 60 VLENPEECILAAEDAIQII------------LKEDIMREDVPRIHARFYNLPKTLMVKEI 107
VL P E + ++A++ + LK+ + + P+TL
Sbjct: 66 VLLKPLEYVEPFDEALRNVVSTLIDPVVHKDLKDKLFYVGFRGSFGDHHVNPRTLR---- 121
Query: 108 GAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKP--------YEGFVAV 159
A H+NK+I +EG+VTR + ++P V +V C+ Q ++ V
Sbjct: 122 -AMHLNKMISLEGIVTRCSFVRPKVIKSVHYCEATKRHHFKQYADATMNGGLSFQSTVYP 180
Query: 160 KKCEKCGSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGD 219
+ E +++ S F + Q +Q+ PE GQ+PR ID +L DD+VDT PGD
Sbjct: 181 TQDENGNPLSIEFGF--STFRDHQSISLQEMPERAPPGQLPRSIDILLDDDLVDTVKPGD 238
Query: 220 RVVVVGILRVVQEKRE--KVPTFKKVIEVNYIEPVSKEIE-------ELEITPEEEQKIR 270
RV +VG R + K TF+ V+ N + + + L+IT + + I
Sbjct: 239 RVNIVGQYRSMGSKTSGNTSATFRTVLLANNVVLLGNKPGLGNVGGGALDITDADIRNIN 298
Query: 271 ELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDP 330
+LA++K++ + + S+AP+IYGY VK+ I L L GG + L +GT +RGDI++L+VGDP
Sbjct: 299 KLARKKNVFELLSTSLAPSIYGYEYVKQAILLLLLGGTEKNLTNGTHIRGDINILMVGDP 358
Query: 331 GVAK 334
AK
Sbjct: 359 STAK 362
>gb|AAD48086.1|AF073330_1 (AF073330) replication origin activator 2 [Zea mays]
Length = 768
Score = 180 bits (452), Expect = 7e-44
Identities = 108/294 (36%), Positives = 163/294 (54%), Gaps = 43/294 (14%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKMND+DR IHE +EQQT++++KAGI
Sbjct: 374 TAAVTSDQETGERRLEAGAMVLADRGVVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGI 433
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +VIAAANP G ++R ++ I LP +L+SRFDL+F+++D+ D +ID +I+
Sbjct: 434 HASLNARCSVIAAANPIYGTYDRSLTPTKNIGLPDSLLSRFDLLFIVLDQMDPEIDRQIS 493
Query: 914 RHILRVRR-------------------------------------GESEVVTPKIPHD-- 934
H+ R+ R G+ K D
Sbjct: 494 EHVARMHRYCTDDGGARSLDKEGYAEEDDGDANAAIFVKYDRMLHGQDRRRGKKSKQDRL 553
Query: 935 ---LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEAL 991
L+KYI YA+ + P +++EA + I Y ++R +++ +PITAR LE +
Sbjct: 554 TVKFLKKYIHYAKNLIQPRLTDEASDHIATSYAELRDG-SANAKSGGGTLPITARTLETI 612
Query: 992 IRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSA 1045
IRLS AHA+M+L V + D A++++ + + + E + + +E+ Q A
Sbjct: 613 IRLSTAHAKMKLRHEVLKSDVEAALQVLNFAIYHKELTEMEEREQREMEMKQQA 666
Score = 146 bits (366), Expect = 9e-34
Identities = 96/341 (28%), Positives = 177/341 (51%), Gaps = 25/341 (7%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
FL FL + +G +Y+ ++D++ + + I L + + +LA V+ P E +
Sbjct: 15 FLDFLDQDVGKG---VYMQAVRDMVQ-NKRHRLIIGMDDLRNHNLDLARRVIRTPGEYMQ 70
Query: 70 AAEDAIQIILK--EDIMREDVPRIHARFYN-------LPKTLMVKEIGAEHINKLIQVEG 120
A DA+ + + + ++ R+ F P+ LM IG ++ VEG
Sbjct: 71 PASDAVSEVARNLDPKFLKEGERVMVGFSGPFGFHRVTPRDLMSSFIGT-----MVCVEG 125
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-----VQLDVE 175
+VT+ + ++P V +V C G + + + FV + +++ + +
Sbjct: 126 IVTKCSLVRPKVVKSVHFCPVTGDFLSREYRDITSFVGLPTGSVYPTRDDNGNLLVTEYG 185
Query: 176 KSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV--QEK 233
++ + Q +Q+ PE GQ+PR +D I+ DD+VD PGDRV +VG+ + + + K
Sbjct: 186 MCEYKDHQTLSMQEVPENSAPGQLPRTVDVIVEDDLVDCCKPGDRVSIVGVYKALPGKSK 245
Query: 234 REKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGY 293
F+ V+ N + ++KE T E+ ++++E+++R D D + +S+AP+IYG+
Sbjct: 246 GSVSGVFRTVLIANNVSLLNKEANAPVYTREDLKRMKEISRRNDTFDLLGNSLAPSIYGH 305
Query: 294 REVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+KK + L + GGV + L +GT LRGDI++++VGDP VAK
Sbjct: 306 LWIKKAVVLLMLGGVEKNLKNGTHLRGDINMMMVGDPSVAK 346
>gb|AAD48087.1|AF073331_1 (AF073331) replication origin activator 3 [Zea mays]
Length = 768
Score = 180 bits (452), Expect = 7e-44
Identities = 108/294 (36%), Positives = 163/294 (54%), Gaps = 43/294 (14%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKMND+DR IHE +EQQT++++KAGI
Sbjct: 374 TAAVTSDQETGERRLEAGAMVLADRGVVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGI 433
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +VIAAANP G ++R ++ I LP +L+SRFDL+F+++D+ D +ID +I+
Sbjct: 434 HASLNARCSVIAAANPIYGTYDRSLTPTKNIGLPDSLLSRFDLLFIVLDQMDPEIDRQIS 493
Query: 914 RHILRVRR-------------------------------------GESEVVTPKIPHD-- 934
H+ R+ R G+ K D
Sbjct: 494 EHVARMHRYCTDDGGARSLDKEGYAEEDDGDANAAIFVKYDRMLHGQDRRRGKKSKQDRL 553
Query: 935 ---LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEAL 991
L+KYI YA+ + P +++EA + I Y ++R +++ +PITAR LE +
Sbjct: 554 TVKFLKKYIHYAKNLIQPRLTDEASDHIATSYAELRDG-SANAKSGGGTLPITARTLETI 612
Query: 992 IRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSA 1045
IRLS AHA+M+L V + D A++++ + + + E + + +E+ Q A
Sbjct: 613 IRLSTAHAKMKLRHEVLKSDVEAALQVLNFAIYHKELTEMEEREQREMEMKQQA 666
Score = 146 bits (366), Expect = 9e-34
Identities = 96/341 (28%), Positives = 177/341 (51%), Gaps = 25/341 (7%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
FL FL + +G +Y+ ++D++ + + I L + + +LA V+ P E +
Sbjct: 15 FLDFLDQDVGKG---VYMQAVRDMVQ-NKRHRLIIGMDDLRNHNLDLARRVIRTPGEYMQ 70
Query: 70 AAEDAIQIILK--EDIMREDVPRIHARFYN-------LPKTLMVKEIGAEHINKLIQVEG 120
A DA+ + + + ++ R+ F P+ LM IG ++ VEG
Sbjct: 71 PASDAVSEVARNLDPKFLKEGERVMVGFSGPFGFHRVTPRDLMSSFIGT-----MVCVEG 125
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-----VQLDVE 175
+VT+ + ++P V +V C G + + + FV + +++ + +
Sbjct: 126 IVTKCSLVRPKVVKSVHFCPVTGDFLSREYRDITSFVGLPTGSVYPTRDDNGNLLVTEYG 185
Query: 176 KSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV--QEK 233
++ + Q +Q+ PE GQ+PR +D I+ DD+VD PGDRV +VG+ + + + K
Sbjct: 186 MCEYKDHQTLSMQEVPENSAPGQLPRTVDVIVEDDLVDCCKPGDRVSIVGVYKALPGKSK 245
Query: 234 REKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGY 293
F+ V+ N + ++KE T E+ ++++E+++R D D + +S+AP+IYG+
Sbjct: 246 GSVSGVFRTVLIANNVSLLNKEANAPVYTREDLKRMKEISRRNDTFDLLGNSLAPSIYGH 305
Query: 294 REVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+KK + L + GGV + L +GT LRGDI++++VGDP VAK
Sbjct: 306 LWIKKAVVLLMLGGVEKNLKNGTHLRGDINMMMVGDPSVAK 346
>pir||T47225 replication licensing factor MCM2 [validated] - African clawed frog
>gi|2231169|gb|AAC60223.1| (U44047) MCM2p [Xenopus
laevis]
Length = 886
Score = 180 bits (452), Expect = 7e-44
Identities = 102/244 (41%), Positives = 147/244 (59%), Gaps = 23/244 (9%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R T W LEAGALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 542 TAYVQRHPVTKEWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 601
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAA+NP GR++ SE ++L ++SRFD++ V+ D D D +A
Sbjct: 602 VTSLQARCTVIAASNPIGGRYDPSLTFSENVDLTEPIVSRFDILCVVRDTVDPVQDEMLA 661
Query: 914 RHILR-----------VRRGE-SEVVTPK------IPHDLLRKYIAYARKNVHPVISEEA 955
R ++ + G+ +E P +P ++L+KYI YA++ + P +++
Sbjct: 662 RFVVSSHIKHHPSSKDIANGDAAEFALPNTFGVEALPQEVLKKYIMYAKEKIRPKLNQMD 721
Query: 956 MEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREA 1015
+++ K Y +RK + IPIT R +E++IR++EAHARM L V +D A
Sbjct: 722 QDKVAKMYSDLRKESMATGS-----IPITVRHIESMIRMAEAHARMHLRDYVVEDDVNMA 776
Query: 1016 IKLM 1019
I++M
Sbjct: 777 IRVM 780
Score = 165 bits (414), Expect = 2e-39
Identities = 109/339 (32%), Positives = 176/339 (51%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + +E ++ KI D+ K S+ +N+ L + + LA + E
Sbjct: 177 RLEIYHRFKNFLRTHVDEHGHNVFKEKISDMCKEN-KESLPVNYEDLAAREHVLAYFLPE 235
Query: 63 NPEECILAAEDAIQIILKEDIMRED--VPRIHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + ++A + ++ + D IH R +LP ++ + H+N+LI+ G
Sbjct: 236 APAEMLKIFDEAAKEVVLVMYPKYDRIAREIHVRISHLPLVEELRSLRQLHLNQLIRTSG 295
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 296 VVTCCTGVLPQLSMVKYNCNKCNFILGPFFQSQNQEVRPGSCPECQSFGPFEINMEETVY 355
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q IQ+ P + G++PR D ILL D+VD+ PGD + + GI +
Sbjct: 356 QNYQRITIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTAN 415
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F VI N+I ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 416 GFPVFATVILANHITKKDDKVAVGELTDEDVKAIVALSKDERIGERIFASIAPSIYGHED 475
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G+ALALFGG + ++RGDI+VLL GDPG AK
Sbjct: 476 IKRGLALALFGGEAKNPGGKHKVRGDINVLLCGDPGTAK 514
>dbj|BAA04642.1| (D21063) KIAA0030 [Homo sapiens]
Length = 914
Score = 180 bits (451), Expect = 1e-43
Identities = 105/247 (42%), Positives = 147/247 (59%), Gaps = 26/247 (10%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R + W LEAGALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 567 TAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 626
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAAANP GR++ SE ++L ++SRFD++ V+ D D D +A
Sbjct: 627 VTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLA 686
Query: 914 RHIL--RVRRGES-------------EVVTPK------IPHDLLRKYIAYARKNVHPVIS 952
R ++ VR S E P +P ++L+KYI YA++ VHP ++
Sbjct: 687 RFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLN 746
Query: 953 EEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDA 1012
+ +++ K Y +RK + IPIT R +E++IR++EAHAR+ L V +D
Sbjct: 747 QMDQDKVAKMYSDLRKESMATGS-----IPITVRHIESMIRMAEAHARIHLRDYVIEDDV 801
Query: 1013 REAIKLM 1019
AI++M
Sbjct: 802 NMAIRVM 808
Score = 169 bits (424), Expect = 1e-40
Identities = 108/339 (31%), Positives = 179/339 (51%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + + ++ +I D+ + S+ +N+ L + + LA + E
Sbjct: 202 RLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKEN-RESLVVNYEDLAAREHVLAYFLPE 260
Query: 63 NPEECI-LAAEDAIQIILKEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + + E A++++L + + IH R +LP ++ + H+N+LI+ G
Sbjct: 261 APAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSG 320
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 321 VVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIY 380
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q RIQ+ P + G++PR D ILL D+VD+ PGD + + GI +
Sbjct: 381 QNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTAN 440
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F VI N++ ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 441 GFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHED 500
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G+ALALFGG P+ ++RGDI+VLL GDPG AK
Sbjct: 501 IKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAK 539
>sp|P49736|MCM2_HUMAN DNA REPLICATION LICENSING FACTOR MCM2 (NUCLEAR PROTEIN BM28)
(KIAA0030) >gi|1232077|dbj|BAA12177.1| (D83987) huMCM2
[Homo sapiens]
Length = 895
Score = 180 bits (451), Expect = 1e-43
Identities = 105/247 (42%), Positives = 147/247 (59%), Gaps = 26/247 (10%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R + W LEAGALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 548 TAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 607
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAAANP GR++ SE ++L ++SRFD++ V+ D D D +A
Sbjct: 608 VTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLA 667
Query: 914 RHIL--RVRRGES-------------EVVTPK------IPHDLLRKYIAYARKNVHPVIS 952
R ++ VR S E P +P ++L+KYI YA++ VHP ++
Sbjct: 668 RFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLN 727
Query: 953 EEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDA 1012
+ +++ K Y +RK + IPIT R +E++IR++EAHAR+ L V +D
Sbjct: 728 QMDQDKVAKMYSDLRKESMATGS-----IPITVRHIESMIRMAEAHARIHLRDYVIEDDV 782
Query: 1013 REAIKLM 1019
AI++M
Sbjct: 783 NMAIRVM 789
Score = 166 bits (415), Expect = 2e-39
Identities = 107/339 (31%), Positives = 178/339 (51%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + + ++ +I D+ + S+ +N+ L + + LA + E
Sbjct: 183 RLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKEN-RESLVVNYEDLAAREHVLAYFLPE 241
Query: 63 NPEECI-LAAEDAIQIILKEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + + E A++++L + + IH R +LP ++ + H+N+LI+ G
Sbjct: 242 APAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSG 301
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 302 VVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIY 361
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q RIQ+ P + G++PR D ILL D+VD+ GD + + GI +
Sbjct: 362 QNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCNAGDEIELTGIYHNNYDGSLNTAN 421
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F VI N++ ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 422 GFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHED 481
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G+ALALFGG P+ ++RGDI+VLL GDPG AK
Sbjct: 482 IKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAK 520
>pir||I51589 P1 homolog - African clawed frog (fragment)
>gi|868012|dbj|BAA07268.1| (D38074) xRlf beta subunit
(p100 protein) [Xenopus laevis]
Length = 806
Score = 179 bits (450), Expect = 1e-43
Identities = 117/333 (35%), Positives = 182/333 (54%), Gaps = 58/333 (17%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 378 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 437
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ + E I L +L+SRFDL+F+++D+ D D EIA
Sbjct: 438 QARLNARCSVLAAANPVYGRYDQYRTPMENIGLQDSLLSRFDLLFIVLDKMDADNDQEIA 497
Query: 914 RHILRVRR----GE----------------------SEVVTPKI----PHD--------- 934
H+LR+ R GE S+V ++ HD
Sbjct: 498 DHVLRMHRYRTPGEQDGYALPLGCSVEIFATDDPNASDVTDQELQIYEKHDNLLHGPRKN 557
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
+RKYI + K + PV++ EA + I + Y K+R + + + + +P+TAR
Sbjct: 558 KSKIVSMQFIRKYI-HVAKLIKPVLTSEAADYISQEYAKIRNH-DQINNDSARTMPVTAR 615
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYT-LRQIAVDETGQIDVTILEVGQSA 1045
LE +IRLS AHA++R+S + R+DA A++L+++ +++ E + D + + S
Sbjct: 616 ALETMIRLSTAHAKVRMSKTIERQDAETALELVQFAYFKKVLAKEKKKTDKDLHDENLSQ 675
Query: 1046 RKLSKVERILDIIEKLEGTSEKGAKIDDILEEA 1078
LS+ E + +S + KI D +++
Sbjct: 676 DTLSQ--------ESVRKSSRRAGKIADSQDDS 700
Score = 135 bits (337), Expect = 2e-30
Identities = 107/349 (30%), Positives = 172/349 (48%), Gaps = 30/349 (8%)
Query: 5 EIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENP 64
E +L FL + ++G LY GK++D++ R I +N + + + A +L +
Sbjct: 13 EAQREYLDFLDDDQDQG---LYHGKVRDMIGSNEHRLI-VNLNDVRRKNDKRANLMLNDA 68
Query: 65 EECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHIN----------K 114
A A Q LK+ + D +A+ + G++H++
Sbjct: 69 ----FAETIAFQRALKDLVASIDAT--YAKQFEEFSVGFEGSFGSKHVSPRTLTASLLGS 122
Query: 115 LIQVEGVVTRVTEIKPFVSSAVFVC---KDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQ 171
L+ VEG+VT+ + ++P V +V C K E F + +N
Sbjct: 123 LVCVEGIVTKCSLVRPKVMRSVHYCPATKKTLERKYSDLTSLEAFPSSSIYPTKDEENNP 182
Query: 172 LDVEK--SKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRV 229
L+ E S + + Q IQ+ P+ GQ+PR +D I DD+VD PGDRV +VGI R
Sbjct: 183 LETEYGLSTYKDHQTLSIQEMPDKAPAGQLPRSVDIIADDDLVDKCKPGDRVQIVGIYRC 242
Query: 230 VQEKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDAIVDS 285
+ K+ TF+ ++ N I+ +SKEI + ++ KI++ K KDI + + S
Sbjct: 243 LPSKQGGFTSGTFRTILLANNIKLMSKEIAPT-FSADDVAKIKKFCKAHSKDIFEHLSKS 301
Query: 286 IAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+AP+I+G+ +KK I L GG + L +GTR+RGDI+VLL+GDP VAK
Sbjct: 302 LAPSIHGHEYIKKAILCMLLGGNEKVLENGTRIRGDINVLLIGDPSVAK 350
>sp|P55861|MCM2_XENLA DNA REPLICATION LICENSING FACTOR MCM2 (X.MCM2)
>gi|2134113|pir||JC5085 replication licensing factor MCM2
- African clawed frog >gi|1753193|dbj|BAA09948.1|
(D63919) xMCM2 [Xenopus laevis]
Length = 886
Score = 178 bits (448), Expect = 2e-43
Identities = 101/244 (41%), Positives = 146/244 (59%), Gaps = 23/244 (9%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R T W LEAGALV AD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 542 TAYVQRHPVTKEWTLEAGALVFADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 601
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAA+NP GR++ SE ++L ++SRFD++ V+ D D D +A
Sbjct: 602 VTSLQARCTVIAASNPIGGRYDPSLTFSENVDLTEPIVSRFDILCVVRDTVDPVQDEMLA 661
Query: 914 RHILR-----------VRRGE-SEVVTPK------IPHDLLRKYIAYARKNVHPVISEEA 955
R ++ + G+ +E P +P ++L+KYI YA++ + P +++
Sbjct: 662 RFVVSSHIKHHPSSKDIANGDAAEFALPNTFGVEALPQEVLKKYIMYAKEKIRPKLNQMD 721
Query: 956 MEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREA 1015
+++ K Y +RK + IPIT R +E++IR++EAHARM L V +D A
Sbjct: 722 QDKVAKIYSDLRKESMATGS-----IPITVRHIESMIRMAEAHARMHLRDYVVEDDVNMA 776
Query: 1016 IKLM 1019
I++M
Sbjct: 777 IRVM 780
Score = 166 bits (416), Expect = 1e-39
Identities = 109/339 (32%), Positives = 176/339 (51%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + +E ++ KI D+ K S+ +N+ L + + LA + E
Sbjct: 177 RLEIYHRFKNFLRTHVDEHGHNVFKEKISDMCKEN-KESLPVNYEDLAAREHVLAYFLPE 235
Query: 63 NPEECILAAEDAIQIILKEDIMRED--VPRIHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + ++A + ++ + D IH R +LP ++ + H+N+LI+ G
Sbjct: 236 APAEMLKIFDEAAKEVVLVMYPKYDRIAREIHVRISHLPLVEELRSLRQLHLNQLIRTSG 295
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 296 VVTCCTGVLPQLSMVKYNCNKCNFILGPFFQSQNQEVRPGSCPECQSFGPFEINMEETVY 355
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q IQ+ P + G++PR D ILL D+VD+ PGD + + GI +
Sbjct: 356 QNYQRITIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTAN 415
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F VI N+I ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 416 GFPVFATVILANHITKKDDKVAVRELTDEDVKAIVALSKDERIGERIFASIAPSIYGHED 475
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G+ALALFGG + ++RGDI+VLL GDPG AK
Sbjct: 476 IKRGLALALFGGEAKNPGGKHKVRGDINVLLCGDPGTAK 514
>sp|Q43704|MCM3_MAIZE DNA REPLICATION LICENSING FACTOR MCM3 HOMOLOG (REPLICATION ORIGIN
ACTIVATOR) (ROA PROTEIN) >gi|1076823|pir||S52247
replication licensing factor MCM3 - maize (fragment)
>gi|609290|emb|CAA82556.1| (Z29368) ROA protein [Zea
mays]
Length = 600
Score = 177 bits (445), Expect = 5e-43
Identities = 107/294 (36%), Positives = 163/294 (55%), Gaps = 43/294 (14%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKMND+DR IHE +EQQT++++KAGI
Sbjct: 206 TAAVTSDQETGERRLEAGAMVLADRGVVCIDEFDKMNDQDRVAIHEVMEQQTVTIAKAGI 265
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +VIAAANP G ++R ++ I LP +L+SRF L+F+++D+ D +ID +I+
Sbjct: 266 HASLNARCSVIAAANPIYGTYDRSLTPTKNIGLPDSLLSRFRLLFIVLDQMDPEIDRQIS 325
Query: 914 RHILRVRR-------------------------------------GESEVVTPKIPHD-- 934
H+ R+ R G+ K D
Sbjct: 326 EHVARMHRYCTDDGGARSLDKEGYAEEDDGDANAAIFIKYDRMLHGQDRRRGKKSKQDRL 385
Query: 935 ---LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEAL 991
L+KYI YA+ + P +++EA + I Y ++R +++ +PITAR LE++
Sbjct: 386 TVKFLKKYIHYAKNLIQPRLTDEASDHIATSYAELRDG-SANAKSGGGTLPITARTLESI 444
Query: 992 IRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSA 1045
IRLS AHA+M+L V + D A++++ + + + E + + +E+ Q A
Sbjct: 445 IRLSTAHAKMKLRHEVLKSDVEAALQVLNFAIYHKELTEMEEREQKEMEMKQQA 498
Score = 123 bits (306), Expect = 1e-26
Identities = 60/159 (37%), Positives = 101/159 (62%), Gaps = 2/159 (1%)
Query: 178 KFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV--QEKRE 235
++ + Q +Q+ PE GQ+PR +D I+ DD+VD PGDRV +VG+ + + + K
Sbjct: 20 EYKDHQTLSMQEVPENSAPGQLPRTVDVIVEDDLVDCCKPGDRVSIVGVYKALPGKSKGS 79
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
F+ V+ N + ++KE T E+ ++++E+++R D D + +S+AP+IYG+
Sbjct: 80 VSGVFRTVLIANNVSLLNKEANAPVYTREDLKRMKEISRRNDTFDLLGNSLAPSIYGHLW 139
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+KK + L + GGV + L +GT LRGDI++++VGDP VAK
Sbjct: 140 IKKAVVLLMLGGVEKNLKNGTHLRGDINMMMVGDPSVAK 178
>sp|Q21902|MCM5_CAEEL DNA REPLICATION LICENSING FACTOR MCM5 HOMOLOG >gi|7506575|pir||T24130
hypothetical protein R10E4.4 - Caenorhabditis elegans
>gi|3879051|emb|CAA90765.1| (Z50874) contains similarity
to Pfam domain: PF00493 (MCM2/3/5 family), Score=983.8,
E-value=1.3e-292, N=1~cDNA EST yk36a9.3 comes from this
gene~cDNA EST yk36d11.3 comes from this gene~cDNA EST
yk41c7.3 comes from this gene~cDNA EST yk29a6.5 comes
fro>
Length = 759
Score = 177 bits (445), Expect = 5e-43
Identities = 101/264 (38%), Positives = 153/264 (57%), Gaps = 31/264 (11%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA+VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 414 TASVIRDPQSRSFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 473
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ R + I+ PT++SRFD+I+++ D D D+ +A
Sbjct: 474 TTTLNSRCSVLAAANSVYGRWDE-SRGDDNIDFMPTILSRFDMIYIVKDTHDVLKDATLA 532
Query: 914 RHILRVRRGESEVV------TPK------------------IPHDLLRKYIAYARKNVHP 949
+H++ V S PK + + L+K++ YAR N P
Sbjct: 533 KHVIEVHVNASAAKERDIAGVPKTATTDSDGVMTMFDTDGFLTIEFLKKFVTYARLNCGP 592
Query: 950 VISEEAMEEIEKYYVKMRKSV------KKSSEEEIKPIPITARQLEALIRLSEAHARMRL 1003
++ +A E++ +YVKMR V K + IPIT RQLEA++R++E+ A+M L
Sbjct: 593 RLTPQASEKLVNHYVKMRNPVVNADAFKSGKKAHNSAIPITVRQLEAIVRIAESIAKMEL 652
Query: 1004 SPIVTREDAREAIKLMEYTLRQIA 1027
T + EA++L + + A
Sbjct: 653 QQFATDKHVEEALRLFRVSTIEAA 676
Score = 156 bits (391), Expect = 1e-36
Identities = 99/356 (27%), Positives = 187/356 (51%), Gaps = 29/356 (8%)
Query: 5 EIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENP 64
++I +F F+R+++ G +Y ++K + + + IN HL +FD ++ ++ + P
Sbjct: 34 QLITQFRNFIRDFSTGGFGMIYRDQLKRNY-FSHEYRLEINLNHLKNFDEDIEMKLRKFP 92
Query: 65 EECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKE-------IGAEHINKLIQ 117
+ + A E+A +I+ E + P+ + +++ TL + E + + ++++++
Sbjct: 93 GKVLPALEEAAKIVADE--ITTPRPKGEEKLHDIQVTLTLDEYPTSLRQVKSAQVSQVVK 150
Query: 118 VEGVVTRVTEIKPFVSSAVFVCKDCGHEMV-VQQKP-YEGFVAVKKC--------EKCGS 167
+ G++ +++ + C+ C H + V KP EGF + C ++C
Sbjct: 151 ISGIIVAAAQVRSKATKVTLQCRQCKHTIPDVSIKPGLEGFALPRTCAAPQQGQMQRCPI 210
Query: 168 KNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGIL 227
+ +K + V++Q ++Q+ PE + G+MPR + + D +PG+RV +VG+
Sbjct: 211 DPYIMLPDKCECVDYQTLKLQENPEDVPHGEMPRHLQLFTERYLTDKVVPGNRVTIVGVY 270
Query: 228 ---RVVQEKR-----EKVPT-FKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDI 278
+++Q+K + + T + +V+ ++ TPEEE+ + LA+RKD
Sbjct: 271 SIKKLIQKKGGDKSLQGIRTPYLRVLGIHMETSGPGRTNFTTFTPEEERMFKTLAQRKDA 330
Query: 279 VDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ I SIAP+IYG ++KK IA LFGG + LPDG RGDI+VLL+GDPG AK
Sbjct: 331 YELIAKSIAPSIYGSADIKKSIACLLFGGARKKLPDGITRRGDINVLLLGDPGTAK 386
>sp|P49739|MCM3_XENLA DNA REPLICATION LICENSING FACTOR MCM3 (X.MCM3) (P1 HOMOLOG) (P100)
>gi|2134104|pir||I51685 replication licensing factor MCM3
[validated] - African clawed frog
>gi|829621|gb|AAA80227.1| (U26057) MCM3 [Xenopus laevis]
Length = 807
Score = 177 bits (445), Expect = 5e-43
Identities = 117/328 (35%), Positives = 178/328 (53%), Gaps = 58/328 (17%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 438
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ + E I L +L+SRFDL+F+++D+ D D EIA
Sbjct: 439 QARLNARCSVLAAANPVYGRYDQYRTPMENIGLQDSLLSRFDLLFIVLDKMDADNDQEIA 498
Query: 914 RHILRVRR----GE----------------------SEVVTPKI----PHD--------- 934
H+LR+ R GE S+V ++ HD
Sbjct: 499 DHVLRMHRYRTPGEQDGYALPLGCSVEIFATDDPNASDVTDQELQIYEKHDNLLHGPRKN 558
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
+RKYI + K + PV++ EA + I + Y K+R + + + +P+TAR
Sbjct: 559 KSKIVSMQFIRKYI-HVAKLIKPVLTSEAADYISQEYAKIRNH-DQINNGSARTMPVTAR 616
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYT-LRQIAVDETGQIDVTILEVGQSA 1045
LE +IRLS AHA++R+S + R+DA A++L+++ +++ E + D + + S
Sbjct: 617 ALETMIRLSTAHAKVRMSKTIERQDAETALELVQFAYFKKVLAKEKKKTDKDLHDENLSQ 676
Query: 1046 RKLSKVERILDIIEKLEGTSEKGAKIDD 1073
LS+ E + +S + KI D
Sbjct: 677 DTLSQ--------ESVRKSSRRAGKIAD 696
Score = 136 bits (340), Expect = 1e-30
Identities = 108/349 (30%), Positives = 172/349 (48%), Gaps = 30/349 (8%)
Query: 5 EIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENP 64
E +L FL + ++G LY GK++D++ R I +N + + + A +L +
Sbjct: 14 EAQREYLDFLDDDQDQG---LYHGKVRDMIGSNEHRLI-VNLNDVRRKNDKRANLMLNDA 69
Query: 65 EECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHIN----------K 114
A A Q LK+ + D +A+ + G++H++
Sbjct: 70 ----FAETIAFQRALKDLVASIDAT--YAKQFEEFSVGFEGSFGSKHVSPRTLTASLLGS 123
Query: 115 LIQVEGVVTRVTEIKPFVSSAVFVC---KDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQ 171
L+ VEG+VT+ + ++P V +V C K E F + +N
Sbjct: 124 LVCVEGIVTKCSLVRPKVMRSVHYCPATKKTLERKYSDLTSLEAFPSSSIYPTKDEENNP 183
Query: 172 LDVEK--SKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRV 229
L+ E S + + Q IQ+ PE GQ+PR +D I DD+VD PGDRV +VGI R
Sbjct: 184 LETEYGLSTYKDHQTLSIQEMPEKAPAGQLPRSVDIIADDDLVDKCKPGDRVQIVGIYRC 243
Query: 230 VQEKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDAIVDS 285
+ K+ TF+ ++ N I+ +SKEI + ++ KI++ K KDI + + S
Sbjct: 244 LPSKQGGFTSGTFRTILLANNIKLMSKEIAPT-FSADDVAKIKKFCKAHSKDIFEHLSKS 302
Query: 286 IAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+AP+I+G+ +KK I L GG + L +GTR+RGDI+VLL+GDP VAK
Sbjct: 303 LAPSIHGHEYIKKAILCMLLGGNEKVLENGTRIRGDINVLLIGDPSVAK 351
>gi|6319679 MCM3 protein homolog (S. cerevisiae); Cdc47p [Saccharomyces
cerevisiae] >gi|419857|pir||S34027 replication licensing
factor MCM7 [validated] - yeast (Saccharomyces
cerevisiae) >gi|311678|emb|CAA79689.1| (Z21487) unknown
[Saccharomyces cerevisiae] >gi|536577|emb|CAA85166.1|
(Z36071) ORF YBR202w [Saccharomyces cerevisiae]
Length = 845
Score = 177 bits (445), Expect = 5e-43
Identities = 126/400 (31%), Positives = 205/400 (50%), Gaps = 26/400 (6%)
Query: 690 VTIEIPEKLRRFIKCDRVRYVDLVEMLSSMEGELKEEVMLLLSDVGDIHEVIQERLKEIG 749
+T ++ E++ I V + + G L + LLL VG + + + + +K G
Sbjct: 393 LTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRG 452
Query: 750 KI---LESDASWERIAEVEEVVRDGHVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGW 806
I L D + ++ + + ++ G ++ V TAAV++D T
Sbjct: 453 DINVCLMGDPGVAKSQLLKAICK------ISPRGVYTTGKGSSGVGLTAAVMKDPVTDEM 506
Query: 807 VLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGITATLNARTTVIAA 866
+LE GALVLAD G IDE DKM++ DR+ IHE +EQQTIS+SKA I ART+++AA
Sbjct: 507 ILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAVINTNPGARTSILAA 566
Query: 867 ANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIARHILRVRRGESEV 926
ANP GR N + INLP L+SRFD++F+++D P D ++A H+ V +
Sbjct: 567 ANPLYGRINPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQP 626
Query: 927 ---VTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPI 983
TP P +R+YIAYA K PV+SE + + + Y+++R+ K+ + +
Sbjct: 627 DLDFTPVEP-SKMREYIAYA-KTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQA 684
Query: 984 TARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQ 1043
T R L +IRLS+A A++RL+ +V +D EA++L+ + + E +
Sbjct: 685 TPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESL-----------YQETNK 733
Query: 1044 SARKLSKVERILDIIEK-LEGTSEKGAKIDDILEEAKKFG 1082
S S +I II+K L+ T + ++I++ + G
Sbjct: 734 SKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRG 773
Score = 136 bits (338), Expect = 2e-30
Identities = 80/245 (32%), Positives = 129/245 (52%), Gaps = 11/245 (4%)
Query: 100 KTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAV 159
K L V++I + + +LI V G++TRV+++KP V + C CG+E V Q+ F +
Sbjct: 223 KPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYE-VFQEVNSRTFTPL 281
Query: 160 KKC--EKCGSKNVQ----LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVD 213
+C E+C + + SKF FQ +IQ+ + + G +PR ++ + +V
Sbjct: 282 SECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVR 341
Query: 214 TAMPGDRVVVVGILRVVQEKREKVPTF----KKVIEVNYIEPVSKEIEELEITPEEEQKI 269
+ PGD V V GI K + +E ++ K+ +T + E+++
Sbjct: 342 SLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERV 401
Query: 270 RELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGD 329
EL D+ + + SIAP IYG +VKK + L L GGV + + DG ++RGDI+V L+GD
Sbjct: 402 MELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGD 461
Query: 330 PGVAK 334
PGVAK
Sbjct: 462 PGVAK 466
>gb|AAC16250.1| (AF004105) BM28 homolog [Mus musculus]
Length = 904
Score = 177 bits (445), Expect = 5e-43
Identities = 104/247 (42%), Positives = 146/247 (59%), Gaps = 26/247 (10%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R + W LEAGALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 557 TAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 616
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAAANP GR++ SE ++L ++SRFD++ V+ D D D +A
Sbjct: 617 VTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLA 676
Query: 914 RHIL--RVRR-------------GESEVVTPK------IPHDLLRKYIAYARKNVHPVIS 952
R ++ VR G E P +P ++L+KYI YA++ V P ++
Sbjct: 677 RFVVGSHVRHHPSNKKDEGLTNGGTLEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLN 736
Query: 953 EEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDA 1012
+ +++ + Y +RK + IPIT R +E++IR++EAHARM L V +D
Sbjct: 737 QMDQDKVARMYSDLRKESMATGS-----IPITVRHIESMIRMAEAHARMHLRDYVMEDDV 791
Query: 1013 REAIKLM 1019
AI++M
Sbjct: 792 NMAIRVM 798
Score = 169 bits (424), Expect = 1e-40
Identities = 107/339 (31%), Positives = 179/339 (52%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + + ++ +I D+ + S+ +N+ L + + LA + E
Sbjct: 192 RLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKEN-RESLVVNYEDLAAREHVLAYFLPE 250
Query: 63 NPEECI-LAAEDAIQIILKEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + + E A++++L + + IH R +LP ++ + H+N+LI+ G
Sbjct: 251 APAELLQIFDEAALEVVLAMHPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSG 310
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 311 VVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEINMEETIY 370
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q RIQ+ P + G++PR D ILL D+VD+ PGD + + GI +
Sbjct: 371 QNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTAN 430
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F +I N++ ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 431 GFPVFATIILANHVAKKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHED 490
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G+ALALFGG P+ ++RGDI+VLL GDPG AK
Sbjct: 491 IKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAK 529
>gi|6678826 mini chromosome maintenance deficient 2 (S. cerevisiae) [Mus
musculus] >gi|2851575|sp|P97310|MCM2_MOUSE DNA
REPLICATION LICENSING FACTOR MCM2 >gi|7428556|pir||T10067
replication licensing factor MCM2 - mouse
>gi|2381485|dbj|BAA22148.1| (D86725) mMCM2 [Mus musculus]
Length = 904
Score = 177 bits (445), Expect = 5e-43
Identities = 104/247 (42%), Positives = 146/247 (59%), Gaps = 26/247 (10%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R + W LEAGALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 557 TAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 616
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAAANP GR++ SE ++L ++SRFD++ V+ D D D +A
Sbjct: 617 VTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLA 676
Query: 914 RHIL--RVRR-------------GESEVVTPK------IPHDLLRKYIAYARKNVHPVIS 952
R ++ VR G E P +P ++L+KYI YA++ V P ++
Sbjct: 677 RFVVGSHVRHHPSNKKDEGLTNGGTLEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLN 736
Query: 953 EEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDA 1012
+ +++ + Y +RK + IPIT R +E++IR++EAHARM L V +D
Sbjct: 737 QMDQDKVARMYSDLRKESMATGS-----IPITVRHIESMIRMAEAHARMHLRDYVMEDDV 791
Query: 1013 REAIKLM 1019
AI++M
Sbjct: 792 NMAIRVM 798
Score = 168 bits (422), Expect = 2e-40
Identities = 107/339 (31%), Positives = 179/339 (52%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + + ++ +I D+ + S+ +N+ L + + LA + E
Sbjct: 192 RLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKEN-RESLVVNYEDLAAREHVLAYFLPE 250
Query: 63 NPEECI-LAAEDAIQIILKEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + + E A++++L + + IH R +LP ++ + H+N+LI+ G
Sbjct: 251 APAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSG 310
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 311 VVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEINMEETIY 370
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q RIQ+ P + G++PR D ILL D+VD+ PGD + + GI +
Sbjct: 371 QNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTAN 430
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F +I N++ ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 431 GFPVFATIILANHVAKKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHED 490
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G+ALALFGG P+ ++RGDI+VLL GDPG AK
Sbjct: 491 IKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAK 529
>gi|6319448 Minichromosome maintenance protein, transcription factor; Mcm2p
[Saccharomyces cerevisiae]
>gi|585465|sp|P29469|MCM2_YEAST MINICHROMOSOME
MAINTENANCE PROTEIN 2 >gi|626737|pir||S45757 replication
licensing factor MCM2 [validated] - yeast (Saccharomyces
cerevisiae) >gi|536021|emb|CAA84842.1| (Z35784) ORF
YBL023c [Saccharomyces cerevisiae]
>gi|602896|emb|CAA54503.1| (X77291) MCM2 [Saccharomyces
cerevisiae]
Length = 868
Score = 176 bits (442), Expect = 1e-42
Identities = 103/272 (37%), Positives = 154/272 (55%), Gaps = 53/272 (19%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V +D T W LE GALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 577 TASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 636
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TL AR ++IAAANP GR+N +++ ++L ++SRFD++ V+ D DE+ D +A
Sbjct: 637 VTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLA 696
Query: 914 RHIL-------------------------RVRRGESEV--------------------VT 928
++ + +GE E+ ++
Sbjct: 697 TFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEIS 756
Query: 929 PKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK-SVKKSSEEEIKPIPITARQ 987
P IP +LL KYI YAR ++P + + M+++ + Y +R+ S+ S PIT R
Sbjct: 757 P-IPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGS------FPITVRH 809
Query: 988 LEALIRLSEAHARMRLSPIVTREDAREAIKLM 1019
LE+++R++E+ A+MRLS V+ D AIK++
Sbjct: 810 LESILRIAESFAKMRLSEFVSSYDLDRAIKVV 841
Score = 168 bits (422), Expect = 2e-40
Identities = 110/339 (32%), Positives = 185/339 (54%), Gaps = 20/339 (5%)
Query: 13 FLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECI---- 68
FL EY +E +Y +I+ L + + S+ +N+ HL LA + + PEE +
Sbjct: 214 FLLEYTDETGRSVYGARIRTLGEMNSE-SLEVNYRHLAESKAILALFLAKCPEEMLKIFD 272
Query: 69 LAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEI 128
L A +A ++ + IH R + P ++E+ +++ L++V GVVTR T +
Sbjct: 273 LVAMEATELHYPDYARIHS--EIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGV 330
Query: 129 KPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKFVNFQMFRI 187
P + F C CG + + + + C C SK +++ EK+ + N+Q +
Sbjct: 331 FPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTL 390
Query: 188 QDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KREKVPTFKKV 243
Q+ P T+ G++PR + ILL D+VD + PG+ V V GI + + + P F +
Sbjct: 391 QEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATI 450
Query: 244 IEVNYIEP----VSKEIEE-LEI---TPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
IE N I+ + E EE L++ T EEE++ R++++ + I+D I+ S+AP+IYG+R+
Sbjct: 451 IEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRD 510
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K +A +LFGGVP+ + +RGDI+VLL+GDPG AK
Sbjct: 511 IKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAK 549
>emb|CAA69609.1| (Y08301) MCM2-related protein [Arabidopsis thaliana]
Length = 491
Score = 176 bits (441), Expect = 1e-42
Identities = 100/246 (40%), Positives = 142/246 (57%), Gaps = 25/246 (10%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV +D T W LE GALVLAD G LIDE DKMND+DR IHEA+EQQ+IS+SKAGI
Sbjct: 138 TAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGI 197
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR +VIAAANP GR++ K ++ + L ++SRFD++ V+ D D D +A
Sbjct: 198 VTSLQARCSVIAAANPVGGRYDSSKSFAQNVELTDPILSRFDILCVVKDVVDPVTDEMLA 257
Query: 914 RHILRVR-------------------RGESEVVTPKI-PHDLLRKYIAYARKNVHPVISE 953
++ +G S P++ P +LL+KY+ Y++ V P + E
Sbjct: 258 EFVVNSHFKSQPKGGKMEDSDPEDGIQGSSGSTDPEVLPQNLLKKYLTYSKLYVFPKLGE 317
Query: 954 EAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAR 1013
+++E Y +R+ + + I R LE++IR+SEAHARM L VT ED
Sbjct: 318 LDAKKLETVYANLRRESMNG-----QGVSIATRHLESMIRMSEAHARMHLRQYVTEEDVN 372
Query: 1014 EAIKLM 1019
AI+++
Sbjct: 373 MAIRVL 378
Score = 93.2 bits (228), Expect = 1e-17
Identities = 44/97 (45%), Positives = 64/97 (65%)
Query: 238 PTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVK 297
P F V+E NY+ ++T E++ +I EL+K IV+ I+ SIAP+IYG+ ++K
Sbjct: 14 PVFATVVEANYVTKKQDLFSAYKLTQEDKTQIEELSKDPRIVERIIKSIAPSIYGHEDIK 73
Query: 298 KGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ALA+FGG + + RLRGDI+VLL+GDPG AK
Sbjct: 74 TALALAMFGGQEKNIKGKHRLRGDINVLLLGDPGTAK 110
>gb|AAF78275.1|AC020576_19 (AC020576) Contains similarity to a MCM2-related protein from
Arabidopsis thaliana gb|Y08301 and contains a MCM
PF|00493 domain
Length = 936
Score = 176 bits (441), Expect = 1e-42
Identities = 100/246 (40%), Positives = 142/246 (57%), Gaps = 25/246 (10%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV +D T W LE GALVLAD G LIDE DKMND+DR IHEA+EQQ+IS+SKAGI
Sbjct: 583 TAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGI 642
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR +VIAAANP GR++ K ++ + L ++SRFD++ V+ D D D +A
Sbjct: 643 VTSLQARCSVIAAANPVGGRYDSSKSFAQNVELTDPILSRFDILCVVKDVVDPVTDEMLA 702
Query: 914 RHILRVR-------------------RGESEVVTPKI-PHDLLRKYIAYARKNVHPVISE 953
++ +G S P++ P +LL+KY+ Y++ V P + E
Sbjct: 703 EFVVNSHFKSQPKGGKMEDSDPEDGIQGSSGSTDPEVLPQNLLKKYLTYSKLYVFPKLGE 762
Query: 954 EAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAR 1013
+++E Y +R+ + + I R LE++IR+SEAHARM L VT ED
Sbjct: 763 LDAKKLETVYANLRRESMNG-----QGVSIATRHLESMIRMSEAHARMHLRQYVTEEDVN 817
Query: 1014 EAIKLM 1019
AI+++
Sbjct: 818 MAIRVL 823
Score = 175 bits (438), Expect = 3e-42
Identities = 107/344 (31%), Positives = 183/344 (53%), Gaps = 15/344 (4%)
Query: 3 REEIIERFLRFLREYAE---EGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEE 59
R I ++F FL Y + E + Y+ I ++++ K S+ I++ P +A
Sbjct: 215 RRFIAKKFKDFLLTYVKPKNENGDIEYVRLINEMVSAN-KCSLEIDYKEFIHVHPNIAIW 273
Query: 60 VLENPEECILAAEDAIQIILKEDIMREDVPRIHARFY----NLPKTLMVKEIGAEHINKL 115
+ + P+ + E+ + ++ + + + IH + Y NLP ++ I H+N +
Sbjct: 274 LADAPQPVLEVMEEVSEKVIFD--LHPNYKNIHTKIYVRVTNLPVNDQIRNIRQIHLNTM 331
Query: 116 IQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDV 174
I++ GVVTR + + P + + C CG + + V V C +C SK ++V
Sbjct: 332 IRIGGVVTRRSGVFPQLQQVKYDCNKCGAVLGPFFQNSYSEVKVGSCSECQSKGPFTVNV 391
Query: 175 EKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILR----VV 230
E++ + N+Q IQ+ P T+ G++PR + ILL+D++D A PG+ + V GI +
Sbjct: 392 EQTIYRNYQKLTIQESPGTVPAGRLPRHKEVILLNDLIDCARPGEEIEVTGIYTNNFDLS 451
Query: 231 QEKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAI 290
+ P F V+E NY+ ++T E++ +I EL+K IV+ I+ SIAP+I
Sbjct: 452 LNTKNGFPVFATVVEANYVTKKQDLFSAYKLTQEDKTQIEELSKDPRIVERIIKSIAPSI 511
Query: 291 YGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
YG+ ++K +ALA+FGG + + RLRGDI+VLL+GDPG AK
Sbjct: 512 YGHEDIKTALALAMFGGQEKNIKGKHRLRGDINVLLLGDPGTAK 555
>emb|CAA37615.1| (X53539) MCM2 [Saccharomyces cerevisiae]
Length = 890
Score = 175 bits (440), Expect = 2e-42
Identities = 102/257 (39%), Positives = 151/257 (58%), Gaps = 38/257 (14%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
T +V + T W LE GALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 577 TRSVRKHPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 636
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TL AR ++IAAANP GR+N +++ ++L ++SRFD++ V+ D DE+ D +A
Sbjct: 637 VTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLA 696
Query: 914 RHIL-----------RVRRGE-------------------SEVVTPKIPHDLLRKYIAYA 943
++ + R GE E ++P IP +LL KYI YA
Sbjct: 697 TFVVDSHVRSHPENDQDREGEELKNNGESAIEQGEDQRKKEEEISP-IPQELLMKYIHYA 755
Query: 944 RKNVHPVISEEAMEEIEKYYVKMRK-SVKKSSEEEIKPIPITARQLEALIRLSEAHARMR 1002
R ++P + + M+++ + Y +R+ S+ S PIT R LE+++R++E+ A+MR
Sbjct: 756 RTKIYPKLHQMDMDKVSRVYADLRRESISTGS------FPITVRHLESILRIAESFAKMR 809
Query: 1003 LSPIVTREDAREAIKLM 1019
LS V+ D AIK++
Sbjct: 810 LSEFVSSYDLDRAIKVV 826
Score = 168 bits (422), Expect = 2e-40
Identities = 110/339 (32%), Positives = 185/339 (54%), Gaps = 20/339 (5%)
Query: 13 FLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECI---- 68
FL EY +E +Y +I+ L + + S+ +N+ HL LA + + PEE +
Sbjct: 214 FLLEYTDETGRSVYGARIRTLGEMNSE-SLEVNYRHLAESKAILALFLAKCPEEMLKIFD 272
Query: 69 LAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEI 128
L A +A ++ + IH R + P ++E+ +++ L++V GVVTR T +
Sbjct: 273 LVAMEATELHYPDYARIHS--EIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGV 330
Query: 129 KPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKFVNFQMFRI 187
P + F C CG + + + + C C SK +++ EK+ + N+Q +
Sbjct: 331 FPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTL 390
Query: 188 QDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KREKVPTFKKV 243
Q+ P T+ G++PR + ILL D+VD + PG+ V V GI + + + P F +
Sbjct: 391 QEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATI 450
Query: 244 IEVNYIEP----VSKEIEE-LEI---TPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
IE N I+ + E EE L++ T EEE++ R++++ + I+D I+ S+AP+IYG+R+
Sbjct: 451 IEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRD 510
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K +A +LFGGVP+ + +RGDI+VLL+GDPG AK
Sbjct: 511 IKTAVACSLFGGVPKNVNPKHSIRGDINVLLLGDPGTAK 549
>pir||T19446 hypothetical protein C25D7.6 - Caenorhabditis elegans
>gi|3874445|emb|CAB02770.1| (Z81039) predicted using
Genefinder~Similarity to Xenopus DNA replication
licensing factor MCM3 (SW:P49739), contains similarity to
Pfam domain: PF00493 (MCM2/3/5 family), Score=883.4,
E-value=2.3e-262, N=1~cDNA EST EMBL:M75844 comes from
this gene; cD>
Length = 812
Score = 175 bits (439), Expect = 3e-42
Identities = 111/270 (41%), Positives = 152/270 (56%), Gaps = 45/270 (16%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D +G LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ +++SKAGI
Sbjct: 382 TAAVTTDPDSGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGI 441
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+N K E I + +L+SRFDLIFVL+DE D D+ +A
Sbjct: 442 HAKLNARCSVLAAANPVYGRYNPFKSPMENIGMQDSLLSRFDLIFVLLDEHDADKDANVA 501
Query: 914 RHILRVR----RGESEVV-------------------------------------TPKIP 932
H+L++ +GE++ T +
Sbjct: 502 EHVLKLHTYRTQGEADGTVLPMGGGVETISTINMETKKASSSIYEENTQWAGIQDTKILT 561
Query: 933 HDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRK-SVKKSSEEEIKPIPITARQLEAL 991
D +RKYI AR +V P +++EA E I + Y +R + K+ +E + +P+TARQLE L
Sbjct: 562 MDFMRKYIHLAR-SVQPKLTDEATEYISEVYADIRSFDITKTDQE--RTMPVTARQLETL 618
Query: 992 IRLSEAHARMRLSPIVTREDAREAIKLMEY 1021
IRLS A A+ R S V RED +A L+ +
Sbjct: 619 IRLSTAIAKARFSKKVEREDTEKAYNLLHF 648
Score = 141 bits (352), Expect = 4e-32
Identities = 95/345 (27%), Positives = 177/345 (50%), Gaps = 21/345 (6%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
++EI E++L FL A+ Y KI ++ R + +N + PE AE +L
Sbjct: 18 KQEITEQYLNFLDNQADTFH---YRQKIVKMMNDGESR-LVMNLDEIREILPERAEGLLT 73
Query: 63 NPEECILAAEDAIQIIL-KEDIMREDVPRIHARFYNL--PKTLMVKEIGAEHINKLIQVE 119
+ + A+Q+ + + D+ H F + + + + + ++ L+ E
Sbjct: 74 QSVLEMNCLQSALQMAINRSDVQAVVKTGFHVGFEGTFGERHVNPRTLKSSYLGNLVCCE 133
Query: 120 GVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKC--------EKCGSKNVQ 171
G+VT+ + ++ + ++V C V +K + F + E ++
Sbjct: 134 GIVTKCSTVRQKLLTSVHYCPATNK---VLEKKFADFTMLDTAVTNNNYPTEDENKNPLE 190
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQ 231
+ S + + Q F IQ+ PE+ GQ+PR +D + D+ D PGDRV ++G+ RV+
Sbjct: 191 TEFGHSVYKDHQTFTIQELPESAPAGQLPRAVDCVADLDLADRVKPGDRVRIIGVFRVLP 250
Query: 232 EKREKVPT--FKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPA 289
K+ V + F+ +I +N+I+ +SKE+ P++ + +R+++K ++ + + S+AP+
Sbjct: 251 NKQNGVSSGSFRSIIIINHIQMLSKEVIP-NFEPQDVKDVRKISKSRNPFELLARSLAPS 309
Query: 290 IYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
I G+ E KK + L GG+ + L +G+RLRGDI+VLL+GDP VAK
Sbjct: 310 ICGHEETKKALLCLLLGGMEKILNNGSRLRGDINVLLIGDPSVAK 354
>emb|CAA72333.1| (Y11594) B24 protein [Triturus carnifex]
Length = 815
Score = 175 bits (438), Expect = 3e-42
Identities = 110/275 (40%), Positives = 158/275 (57%), Gaps = 49/275 (17%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG L+ GA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 380 TAAVTTDQETGERRLDVGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 439
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D D EI+
Sbjct: 440 QARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIVLDQMDADNDREIS 499
Query: 914 RHILRVRR----GE-----------SEVVTPKIP---------------HD--------- 934
H+LR+ R GE EV T P HD
Sbjct: 500 DHVLRMHRYRAQGELDGHALPLGCSVEVFTTDDPNAQNEAEQELQIYEKHDNLLHGPRTK 559
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
+RKYI + K V PV+S+EA + I + Y K+R S + + E + +P+TAR
Sbjct: 560 RDKVVSMQFIRKYI-HVAKLVKPVLSQEAADYIAEEYSKIR-SHDQMNNERARTMPVTAR 617
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEY 1021
LE +IRLS AHA++R+S + +DA A++L+++
Sbjct: 618 ALETMIRLSTAHAKLRMSKTIDIQDAEVALELVQF 652
Score = 131 bits (327), Expect = 3e-29
Identities = 100/339 (29%), Positives = 173/339 (50%), Gaps = 19/339 (5%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
+L FL + ++G +Y GK++D+++ R I +N L A +L + ++
Sbjct: 19 YLDFLDDDQDQG---VYHGKVRDMISENQHRLI-VNLNDLRRKSEARANRLLNDSFGEVI 74
Query: 70 AAEDAIQIILK--EDIMREDVPRIHARFYNL--PKTLMVKEIGAEHINKLIQVEGVVTRV 125
A + A++ ++ + + + F K + + +GA+ + L+ VEG+VT+
Sbjct: 75 AFQKALKDMVSSIDATYSKQFEEFNVGFEGSFGTKHVSPRTLGAQFLGNLLCVEGIVTKC 134
Query: 126 TEIKPFVSSAVFVC---KDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKS--KFV 180
+ ++P V +V C K + F + +N L+ E +
Sbjct: 135 SLVRPKVMRSVHYCPATKKTLERKYTDLTSLDPFPSSAVYPTKDEENNPLETEYGLCTYK 194
Query: 181 NFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPG-DRVVVVGILRVVQEKREKVP- 238
+ Q IQ+ PE GQ+PR ID I DD+VD+ PG DRV +VGI R + K+
Sbjct: 195 DHQTLTIQEMPEKAPAGQLPRSIDIIADDDLVDSCKPGSDRVQIVGIYRRLPSKQGGFTS 254
Query: 239 -TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDAIVDSIAPAIYGYRE 295
TF+ ++ N ++ +SKE+ + ++ KI++ + KDI + + S+AP+I+G+
Sbjct: 255 GTFRTIMLANNVKQMSKEMAPT-FSADDVAKIKKFCRTHSKDIFEHLSKSLAPSIHGHEY 313
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+KK I L GG + L +GTR+RGDI+VLL+GDP VAK
Sbjct: 314 IKKAILCMLLGGNEKILENGTRIRGDINVLLIGDPSVAK 352
>pir||I51022 replication licensing factor MCM3 - eastern newt (fragment)
>gi|467691|emb|CAA55125.1| (X78322) B24 protein
[Notophthalmus viridescens]
Length = 744
Score = 175 bits (438), Expect = 3e-42
Identities = 117/332 (35%), Positives = 183/332 (54%), Gaps = 54/332 (16%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG L+ GA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 377 TAAVTTDQETGERRLDMGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 436
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D D EI+
Sbjct: 437 QARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIVLDQMDADSDREIS 496
Query: 914 RHILRVRR----GES-----------EVVTPKIP---------------HD--------- 934
H+LR+ R GE EV P HD
Sbjct: 497 DHVLRMHRYRAQGERDGHALPLGCNVEVFATDDPNAQNEAEEELQIYEKHDNLLHGPRAK 556
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
+RKYI + K V PV+S+EA + I + Y K+R S + + E + +P+TAR
Sbjct: 557 REKVVSMQFIRKYI-HVAKLVKPVLSQEAADYIAEEYSKIR-SHDQMNNERARTMPVTAR 614
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSAR 1046
LE +IRLS AHA++R+S + +DA A++L+++ Q +++ + ++ G +
Sbjct: 615 ALETMIRLSTAHAKLRMSKTIDIQDAEVALELIQFAYFQKVLEKEKK---KVVGDGINED 671
Query: 1047 KLSKVERILDIIEK--LEGTSEKGAKIDDILE 1076
S+V + + K G+ ++G +++D ++
Sbjct: 672 NSSQVVPSQESVRKSSKRGSKDEGDEMEDTMD 703
Score = 133 bits (332), Expect = 9e-30
Identities = 101/338 (29%), Positives = 169/338 (49%), Gaps = 18/338 (5%)
Query: 10 FLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECIL 69
+L FL + ++G LY GK++D+++ R I +N L D A +L + ++
Sbjct: 17 YLDFLDDDQDQG---LYHGKVRDMISENRHRLI-VNMNDLRRNDEARANRLLNDAFGEVI 72
Query: 70 AAEDAIQIILK--EDIMREDVPRIHARFYNLPKTLMV--KEIGAEHINKLIQVEGVVTRV 125
A + A++ ++ + + F T V + +G + L+ VEG+VT+
Sbjct: 73 AFQKALKDMVSSIDATYSKQFEEFSIGFEGSFGTNDVSPRTLGRHFLGNLVCVEGIVTKC 132
Query: 126 TEIKPFVSSAVFVC---KDCGHEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKS--KFV 180
+ ++P V +V C K + F + +N L+ E +
Sbjct: 133 SLVRPKVMRSVHYCPATKKTLERKYTDLTSLDPFPSSAVYPTKDEENNPLETEYGLCTYK 192
Query: 181 NFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVP-- 238
+ Q IQ+ PE GQ+PR +D I DD+VD+ PGDRV +VGI R + K+
Sbjct: 193 DHQTLTIQEMPEKAPAGQLPRSVDIIADDDLVDSCKPGDRVQIVGIYRCLPSKQGGFTSG 252
Query: 239 TFKKVIEVNYIEPVSKEIEELEITPEEEQKIREL--AKRKDIVDAIVDSIAPAIYGYREV 296
TF+ ++ N ++ +SKE+ + ++ KI++ A DI + S+AP+I+G+ +
Sbjct: 253 TFRTIMLANNVKQMSKEMAPT-FSADDVAKIKKFCRAHTNDIFQHLSKSLAPSIHGHEYI 311
Query: 297 KKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
KK I L GG + L +GTR+RGDI+VLL+GDP VAK
Sbjct: 312 KKAILCMLLGGNEKVLENGTRIRGDINVLLIGDPSVAK 349
>dbj|BAA07267.1| (D38073) hRlf beta subunit (p102 protein) [Homo sapiens]
Length = 808
Score = 173 bits (434), Expect = 1e-41
Identities = 118/358 (32%), Positives = 188/358 (51%), Gaps = 76/358 (21%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 438
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D + D EI+
Sbjct: 439 HARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREIS 498
Query: 914 RHILRVRR----GES-----------EVVTPKIP---------------HD--------- 934
H+LR+ R GE +++ P HD
Sbjct: 499 DHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKK 558
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
++KYI + K + PV+++E+ I + Y ++R S S + + P+TAR
Sbjct: 559 KEKMVSAAFMKKYI-HVAKIIKPVLTQESATYIAEEYSRLR-SQDSMSSDTARTSPVTAR 616
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSAR 1046
LE LIRL+ AHA+ R+S V +DA EA++L++Y
Sbjct: 617 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY------------------------- 651
Query: 1047 KLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEAREILEKLLEQGQIYMP 1104
+ +++L+ +K + SE ++ +D E++++ +K++ R+ + + G Y P
Sbjct: 652 --AYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDP 707
Score = 135 bits (337), Expect = 2e-30
Identities = 102/353 (28%), Positives = 178/353 (49%), Gaps = 27/353 (7%)
Query: 1 MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV 60
+D E+ E +L +E ++ +Y K+++L++ R I +N L + + A +
Sbjct: 7 LDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLI-VNVNDLRRKNEKRANRL 65
Query: 61 LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINK------ 114
L N E ++A + A++ + + +A+ Y + G++H++
Sbjct: 66 LNNAFEELVAFQRALKDFVAS------IDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSC 119
Query: 115 ----LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN- 169
++ VEG+VT+ + ++P V +V C + + VA +K+
Sbjct: 120 FLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDE 179
Query: 170 ----VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVG 225
++ + S + + Q IQ+ PE GQ+PR +D IL DD+VD A GDRV VVG
Sbjct: 180 ENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKANAGDRVQVVG 239
Query: 226 ILRVVQEKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDA 281
R + K+ TF+ V+ ++ +SK+ + + E+ KI++ +K KDI D
Sbjct: 240 TYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQP-SFSAEDIAKIKKFSKTRSKDIFDQ 298
Query: 282 IVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ S+AP+I+G+ VKK I L GGV R L +G+ +RGDI++LL+GDP VAK
Sbjct: 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAK 351
>gi|6631095 minichromosome maintenance deficient (S. cerevisiae) 3;
Minichromosome maintenance, S. cerevisiae, homolog of, 3
[Homo sapiens] >gi|11417476|ref|XP_004096.1|
minichromosome maintenance deficient (S. cerevisiae) 3
[Homo sapiens] >gi|5824000|emb|CAA44078.2| (X62153) P1.h
protein [Homo sapiens] >gi|6969149|emb|CAB75298.1|
(AL034343) dJ108C2.1 (minichromosome maintenance
deficient (S. cerevisiae) 3 (DNA replication licensing
factor, DNA polymerase alpha holoenzyme-associated
protein P1, RLF beta subunit)) [Homo sapiens]
Length = 808
Score = 173 bits (434), Expect = 1e-41
Identities = 118/358 (32%), Positives = 188/358 (51%), Gaps = 76/358 (21%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 438
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D + D EI+
Sbjct: 439 HARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREIS 498
Query: 914 RHILRVRR----GES-----------EVVTPKIP---------------HD--------- 934
H+LR+ R GE +++ P HD
Sbjct: 499 DHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKK 558
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
++KYI + K + PV+++E+ I + Y ++R S S + + P+TAR
Sbjct: 559 KEKMVSAAFMKKYI-HVAKIIKPVLTQESATYIAEEYSRLR-SQDSMSSDTARTSPVTAR 616
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSAR 1046
LE LIRL+ AHA+ R+S V +DA EA++L++Y
Sbjct: 617 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY------------------------- 651
Query: 1047 KLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEAREILEKLLEQGQIYMP 1104
+ +++L+ +K + SE ++ +D E++++ +K++ R+ + + G Y P
Sbjct: 652 --AYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDP 707
Score = 139 bits (346), Expect = 2e-31
Identities = 103/353 (29%), Positives = 179/353 (50%), Gaps = 27/353 (7%)
Query: 1 MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV 60
+D E+ E +L +E ++ +Y K+++L++ R I +N L + + A +
Sbjct: 7 LDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLI-VNVNDLRRKNEKRANRL 65
Query: 61 LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINK------ 114
L N E ++A + A++ + + +A+ Y + G++H++
Sbjct: 66 LNNAFEELVAFQRALKDFVAS------IDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSC 119
Query: 115 ----LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN- 169
++ VEG+VT+ + ++P V +V C + + VA +K+
Sbjct: 120 FLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDE 179
Query: 170 ----VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVG 225
++ + S + + Q IQ+ PE GQ+PR +D IL DD+VD A PGDRV VVG
Sbjct: 180 ENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVG 239
Query: 226 ILRVVQEKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDA 281
R + K+ TF+ V+ ++ +SK+ + + E+ KI++ +K KDI D
Sbjct: 240 TYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQP-SFSAEDIAKIKKFSKTRSKDIFDQ 298
Query: 282 IVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ S+AP+I+G+ VKK I L GGV R L +G+ +RGDI++LL+GDP VAK
Sbjct: 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAK 351
>dbj|BAA34731.1| (AB010107) MCM3 [Drosophila melanogaster]
Length = 819
Score = 173 bits (433), Expect = 1e-41
Identities = 112/283 (39%), Positives = 157/283 (54%), Gaps = 48/283 (16%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ +++SKAGI
Sbjct: 374 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGI 433
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +V+AAANP GR+++ K E I L +L+SRFDL+FV++D D +D I+
Sbjct: 434 HASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMIS 493
Query: 914 RHILRVRR---------------------------------------------GESEVVT 928
H++R+ R G+S +
Sbjct: 494 DHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRLRH 553
Query: 929 PKI-PHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQ 987
KI + +RKYI A K + P + E+A E I Y ++R S + + + PITAR
Sbjct: 554 EKILSVEFMRKYIHIA-KCMKPKLGEQACEAIANEYSRLR-SQEADETDVARTQPITART 611
Query: 988 LEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDE 1030
LE LIRLS AHAR R+S VT +DA AI+L+++ + +D+
Sbjct: 612 LETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDK 654
Score = 157 bits (392), Expect = 8e-37
Identities = 116/345 (33%), Positives = 183/345 (52%), Gaps = 22/345 (6%)
Query: 8 ERFLRFL-REYAE----EGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
E+F++ + REY + E ++ +Y G +KD++A KR I +N L +P+ A +L
Sbjct: 6 EQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLI-VNVNDLKRKNPQRALGLLS 64
Query: 63 NPEECILAAEDAIQIILKE-----DIMREDV-PRIHARFYNLPKTLMVKEIGAEHINKLI 116
N + LA A++ M ED+ F N + + + + + ++ ++
Sbjct: 65 NAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGN--RHVTPRSLTSIYLGNMV 122
Query: 117 QVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-----VQ 171
VEG+VT+V+ I+P V V C + M + F AV +K+ ++
Sbjct: 123 CVEGIVTKVSLIRPKVVRCVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDGNLLE 182
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQ 231
+ S + + Q IQ+ PE GQ+PR +D + DD+VD PGDRV +VG R +
Sbjct: 183 TEYGLSVYKDDQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLP 242
Query: 232 EKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPA 289
KR TF+ V+ N I +SKE L+I+ E+ ++LAK DI + + S+AP+
Sbjct: 243 GKRGGYTSGTFRTVLLANNISQLSKE-SNLDISREDIMLCKKLAKNNDIFELLSKSLAPS 301
Query: 290 IYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
I+G+ VK+ I L GGV + LP+GTRLRGDI+VLL+GDP VAK
Sbjct: 302 IHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAK 346
>sp|P25205|MCM3_HUMAN DNA REPLICATION LICENSING FACTOR MCM3 (DNA POLYMERASE ALPHA
HOLOENZYME-ASSOCIATED PROTEIN P1) (RLF BETA SUBUNIT)
(P102 PROTEIN) (P1-MCM3) >gi|2135007|pir||S62594
replication licensing factor MCM3 - human
Length = 808
Score = 172 bits (431), Expect = 2e-41
Identities = 117/358 (32%), Positives = 185/358 (50%), Gaps = 76/358 (21%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 438
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D + D EI+
Sbjct: 439 HARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREIS 498
Query: 914 RHILRVR--RGESEVVTPKIP----------------------------HD--------- 934
H+LR+ R E +P HD
Sbjct: 499 DHVLRIHGYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKK 558
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
++KYI + K + PV+++E+ I + Y ++R S S + + P+TAR
Sbjct: 559 KEKMVSAAFMKKYI-HVAKIIKPVLTQESATYIAEEYSRLR-SQDSMSSDTARTSPVTAR 616
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDETGQIDVTILEVGQSAR 1046
LE LIRL+ AHA+ R+S V +DA EA++L++Y
Sbjct: 617 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY------------------------- 651
Query: 1047 KLSKVERILDIIEKLEGTSEKGAKIDDILEEAKKFGIEKQEAREILEKLLEQGQIYMP 1104
+ +++L+ +K + SE ++ +D E++++ +K++ R+ + + G Y P
Sbjct: 652 --AYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDP 707
Score = 131 bits (325), Expect = 6e-29
Identities = 101/353 (28%), Positives = 176/353 (49%), Gaps = 27/353 (7%)
Query: 1 MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV 60
+D E+ E +L +E ++ +Y K+++L++ R I +N L + + A +
Sbjct: 7 LDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLI-VNVNDLRRKNEKRANRL 65
Query: 61 LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINK------ 114
L N E ++A + A++ + + +A+ Y + G++H++
Sbjct: 66 LNNAFEEMVAFQRALKDFVAS------IDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSC 119
Query: 115 ----LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN- 169
++ VEG+ T+ + ++ V +V C + + VA +K+
Sbjct: 120 FLSCVVCVEGLCTKCSLVRSKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDE 179
Query: 170 ----VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVG 225
++ + S + Q IQ+ PE GQ+PR +D IL DD+VD A PGDRV VVG
Sbjct: 180 ENNPLETEYGLSVYRYHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVG 239
Query: 226 ILRVVQEKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDA 281
R V K+ TF+ V+ ++ +SK+ + + E+ KI++ +K KDI +
Sbjct: 240 TYRCVPGKKGGYTSGTFRTVLIACNVKQMSKDAQP-SFSAEDIAKIKKFSKTRSKDIFEQ 298
Query: 282 IVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ S+AP+I+G+ VKK I L GGV R L +G+ +RGDI++LL+GDP VAK
Sbjct: 299 LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAK 351
>gb|AAG37990.1|AF095948_1 (AF095948) DNA replication licensing factor MCM2 [Plasmodium
falciparum]
Length = 971
Score = 171 bits (430), Expect = 3e-41
Identities = 104/249 (41%), Positives = 143/249 (56%), Gaps = 31/249 (12%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V +D T W LE GALVLAD G +IDE DKM DKDR IHEA+EQQ+IS+SKAGI
Sbjct: 594 TAGVRKDHTTNEWTLEGGALVLADEGICIIDEFDKMTDKDRVSIHEAMEQQSISISKAGI 653
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TL AR VIAAANP GR+N E ++L ++SRFDLI VL D P+ D +A
Sbjct: 654 VTTLRARCAVIAAANPIYGRYNPSLTFKENVDLSDPILSRFDLITVLRDIPNVDEDFYLA 713
Query: 914 RHIL------------------RVRRGESEVVTPK----IPHDLLRKYIAYARKNVHPVI 951
+++ R+ ++ +V+ IP DLL+KYI YAR N P +
Sbjct: 714 EYVVTNHQLSHPKLENTQNYQKRIENLKNVIVSSSAYEPIPQDLLQKYIIYARTNCKPSL 773
Query: 952 SE----EAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIV 1007
S+ E ++ +Y ++R+ S P+T R +E++IR++EA+A+MRLS +
Sbjct: 774 SDVPYAEISAKLSNFYSRVRQKACASG-----GYPLTLRHIESIIRIAEANAKMRLSHQI 828
Query: 1008 TREDAREAI 1016
+D AI
Sbjct: 829 YSKDVDYAI 837
Score = 120 bits (299), Expect = 7e-26
Identities = 93/348 (26%), Positives = 165/348 (46%), Gaps = 47/348 (13%)
Query: 26 YIGKIKDLLAITPKRSIAINWMHLNSFDPE--------LAEEVLENPEECILAAEDAIQI 77
YI KI+ ++ + K ++ ++ HL F E E++LE EC++ I
Sbjct: 227 YIDKIEKMI-LNDKHTLIVSAKHLIQFHCENLVQWIEFKPEQILEVLHECLMVEAYRISP 285
Query: 78 ILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVF 137
L + + + V R + P + ++ + +N LI+V GV + + P +
Sbjct: 286 KLYKGRICKVVLR------DWPYSTQLRNLRCTELNTLIKVTGVCIKRGYVLPKLRVMYL 339
Query: 138 VCKDCG---HEMVVQQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFVNFQMFRIQDRPETL 194
C C E+ + + V ++C C S +D K+ + ++Q +Q+ P ++
Sbjct: 340 KCNSCDTTLSEVPIYFADGKKPVLPRRCPHCQSATFSVDRIKTAYTDYQKITLQESPCSV 399
Query: 195 KGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKV----PTFKKVIEVNYIE 250
G+ PR + ++ D+VD PG+ V V+GI + + + P + IE N IE
Sbjct: 400 PAGRAPRQREVVVTGDLVDKVKPGEEVEVLGIYKTKYDIGLNIKYGFPILQTEIEANNIE 459
Query: 251 PVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPR 310
++I+ E+T ++ + I +L+K +I + I+ SIAPAI+G++++K IA ALFGGV +
Sbjct: 460 R-KEDIQLSELTEDDIKDILKLSKDPNIRERIITSIAPAIWGHKDIKTSIAYALFGGVQK 518
Query: 311 ------------------------TLPDGTRLRGDIHVLLVGDPGVAK 334
G +RGDI+VLL+GDPG+ K
Sbjct: 519 GGDKSFSKNNETNNFGVQNRDILNNFKGGHTIRGDINVLLLGDPGLGK 566
>gb|AAD32859.1|AF124745_1 (AF124745) DNA replication factor MCM3 [Drosophila melanogaster]
>gi|7290573|gb|AAF46023.1| (AE003434) Mcm3 gene product
[Drosophila melanogaster]
Length = 819
Score = 171 bits (428), Expect = 5e-41
Identities = 112/283 (39%), Positives = 156/283 (54%), Gaps = 48/283 (16%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ +++SKAGI
Sbjct: 374 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGI 433
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A+LNAR +V+AAANP GR+++ K E I L +L+SRFDL+FV++D D +D I+
Sbjct: 434 HASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMIS 493
Query: 914 RHILRVRR---------------------------------------------GESEVVT 928
H++R+ R G+S
Sbjct: 494 DHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRH 553
Query: 929 PKI-PHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQ 987
KI + +RKYI A K + P + E+A E I Y ++R S + + + PITAR
Sbjct: 554 EKILSVEFMRKYIHIA-KCMKPKLGEQACEAIANEYSRLR-SQEAVETDVARTQPITART 611
Query: 988 LEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDE 1030
LE LIRLS AHAR R+S VT +DA AI+L+++ + +D+
Sbjct: 612 LETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDK 654
Score = 157 bits (393), Expect = 6e-37
Identities = 116/345 (33%), Positives = 184/345 (52%), Gaps = 22/345 (6%)
Query: 8 ERFLRFL-REYAE----EGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
E+F++ + REY + E ++ +Y G +KD++A KR I +N L +P+ A +L
Sbjct: 6 EQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLI-VNVNDLKRKNPQRALGLLS 64
Query: 63 NPEECILAAEDAIQIILKE-----DIMREDV-PRIHARFYNLPKTLMVKEIGAEHINKLI 116
N + LA A++ M ED+ F N + + + + + ++ ++
Sbjct: 65 NAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGN--RHVTPRSLTSIYLGNMV 122
Query: 117 QVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-----VQ 171
VEG+VT+V+ I+P V +V C + M + F AV +K+ ++
Sbjct: 123 CVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDGNLLE 182
Query: 172 LDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQ 231
+ S + + Q IQ+ PE GQ+PR +D + DD+VD PGDRV +VG R +
Sbjct: 183 TEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLP 242
Query: 232 EKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPA 289
KR TF+ V+ N I +SKE L+I+ E+ ++LAK DI + + S+AP+
Sbjct: 243 GKRGGYTSGTFRTVLLANNISLLSKE-SNLDISREDIMLCKKLAKNNDIFELLSKSLAPS 301
Query: 290 IYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
I+G+ VK+ I L GGV + LP+GTRLRGDI+VLL+GDP VAK
Sbjct: 302 IHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAK 346
>pir||S17100 P1.m protein - mouse (fragment) >gi|53551|emb|CAA44079.1| (X62154)
P1.m protein [Mus musculus]
Length = 795
Score = 169 bits (425), Expect = 1e-40
Identities = 105/275 (38%), Positives = 153/275 (55%), Gaps = 49/275 (17%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 362 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 421
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D + D EI+
Sbjct: 422 HARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREIS 481
Query: 914 RHILRVR--RGESEVVTPKIP----------------------------HD--------- 934
H+LR+ R E +P HD
Sbjct: 482 DHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDSLLHGTKKK 541
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
++KYI + K + P +++E+ I + Y ++R S S + + P+TAR
Sbjct: 542 KEKMVSAAFMKKYI-HVAKIIKPTLTQESAAYIAEEYSRLR-SQDSMSSDTARTSPVTAR 599
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEY 1021
LE LIRL+ AHA+ R+S V +DA EA++L++Y
Sbjct: 600 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 634
Score = 131 bits (326), Expect = 4e-29
Identities = 96/342 (28%), Positives = 174/342 (50%), Gaps = 27/342 (7%)
Query: 12 RFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECILAA 71
R L +E ++ +Y K+++L++ R I ++ L + + A +L N E ++A
Sbjct: 1 RLLGLLDDEEDQGIYQNKVRELISDNQYRLI-VSVNDLRRKNEKRANRLLNNAFEELVAF 59
Query: 72 EDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINK----------LIQVEGV 121
+ A++ + + +A+ Y + G++H++ ++ VEG+
Sbjct: 60 QRALKDFVAS------IDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGI 113
Query: 122 VTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-----VQLDVEK 176
VT+ + ++P V +V C + + VA +K+ ++ +
Sbjct: 114 VTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGL 173
Query: 177 SKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREK 236
S + + Q IQ+ PE GQ+PR +D IL DD+VD PGDR+ VVG R + K+
Sbjct: 174 SVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGC 233
Query: 237 VP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDAIVDSIAPAIYG 292
TF+ V+ ++ +SK+I+ + ++ KI++ +K KD+ + + S+AP+I+G
Sbjct: 234 YTSGTFRTVLIACNVKQMSKDIQPA-FSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHG 292
Query: 293 YREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ VKK I L GGV R L +G+ +RGDI++LL+GDP VAK
Sbjct: 293 HDYVKKAILCLLLGGVERELENGSHIRGDINILLIGDPSVAK 334
>sp|P25206|MCM3_MOUSE DNA REPLICATION LICENSING FACTOR MCM3 (DNA POLYMERASE ALPHA
HOLOENZYME-ASSOCIATED PROTEIN P1) (P1-MCM3)
Length = 812
Score = 169 bits (425), Expect = 1e-40
Identities = 105/275 (38%), Positives = 153/275 (55%), Gaps = 49/275 (17%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 379 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 438
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D + D EI+
Sbjct: 439 HARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREIS 498
Query: 914 RHILRVR--RGESEVVTPKIP----------------------------HD--------- 934
H+LR+ R E +P HD
Sbjct: 499 DHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDSLLHGTKKK 558
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
++KYI + K + P +++E+ I + Y ++R S S + + P+TAR
Sbjct: 559 KEKMVSAAFMKKYI-HVAKIIKPTLTQESAAYIAEEYSRLR-SQDSMSSDTARTSPVTAR 616
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEY 1021
LE LIRL+ AHA+ R+S V +DA EA++L++Y
Sbjct: 617 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 651
Score = 132 bits (329), Expect = 2e-29
Identities = 98/353 (27%), Positives = 179/353 (49%), Gaps = 27/353 (7%)
Query: 1 MDREEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEV 60
+D E+ E +L +E ++ +Y K+++L++ R I ++ L + + A +
Sbjct: 7 LDDVELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLI-VSVNDLRRKNEKRANRL 65
Query: 61 LENPEECILAAEDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINK------ 114
L N E ++A + A++ + + +A+ Y + G++H++
Sbjct: 66 LNNAFEELVAFQRALKDFVAS------IDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSC 119
Query: 115 ----LIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN- 169
++ VEG+VT+ + ++P V +V C + + VA +K+
Sbjct: 120 FLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDE 179
Query: 170 ----VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVG 225
++ + S + + Q IQ+ PE GQ+PR +D IL DD+VD PGDR+ VVG
Sbjct: 180 ENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVG 239
Query: 226 ILRVVQEKREKVP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDA 281
R + K+ TF+ V+ ++ +SK+I+ + ++ KI++ +K KD+ +
Sbjct: 240 TYRCLPGKKGCYTSGTFRTVLIACNVKQMSKDIQPA-FSADDIAKIKKFSKTRSKDVFEQ 298
Query: 282 IVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ S+AP+I+G+ VKK I L GGV R L +G+ +RGDI++LL+GDP VAK
Sbjct: 299 LARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIGDPSVAK 351
>pir||S22804 replication licensing factor MCM3 - mouse (fragment)
Length = 795
Score = 169 bits (425), Expect = 1e-40
Identities = 105/275 (38%), Positives = 153/275 (55%), Gaps = 49/275 (17%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D+ TG LEAGA+VLAD G IDE DKM+D DR+ IHE +EQ ++++KAGI
Sbjct: 362 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGI 421
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
A LNAR +V+AAANP GR+++ K E I L +L+SRFDL+F+++D+ D + D EI+
Sbjct: 422 HARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREIS 481
Query: 914 RHILRVR--RGESEVVTPKIP----------------------------HD--------- 934
H+LR+ R E +P HD
Sbjct: 482 DHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDSLLHGTKKK 541
Query: 935 --------LLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITAR 986
++KYI + K + P +++E+ I + Y ++R S S + + P+TAR
Sbjct: 542 KEKMVSAAFMKKYI-HVAKIIKPTLTQESAAYIAEEYSRLR-SQDSMSSDTARTSPVTAR 599
Query: 987 QLEALIRLSEAHARMRLSPIVTREDAREAIKLMEY 1021
LE LIRL+ AHA+ R+S V +DA EA++L++Y
Sbjct: 600 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 634
Score = 131 bits (326), Expect = 4e-29
Identities = 96/342 (28%), Positives = 174/342 (50%), Gaps = 27/342 (7%)
Query: 12 RFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLENPEECILAA 71
R L +E ++ +Y K+++L++ R I ++ L + + A +L N E ++A
Sbjct: 1 RLLGLLDDEEDQGIYQNKVRELISDNQYRLI-VSVNDLRRKNEKRANRLLNNAFEELVAF 59
Query: 72 EDAIQIILKEDIMREDVPRIHARFYNLPKTLMVKEIGAEHINK----------LIQVEGV 121
+ A++ + + +A+ Y + G++H++ ++ VEG+
Sbjct: 60 QRALKDFVAS------IDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGI 113
Query: 122 VTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-----VQLDVEK 176
VT+ + ++P V +V C + + VA +K+ ++ +
Sbjct: 114 VTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEEKNPLETEYGL 173
Query: 177 SKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREK 236
S + + Q IQ+ PE GQ+PR +D IL DD+VD PGDR+ VVG R + K+
Sbjct: 174 SVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGC 233
Query: 237 VP--TFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR--KDIVDAIVDSIAPAIYG 292
TF+ V+ ++ +SK+I+ + ++ KI++ +K KD+ + + S+AP+I+G
Sbjct: 234 YTSGTFRTVLIACNVKQMSKDIQPA-FSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHG 292
Query: 293 YREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+ VKK I L GGV R L +G+ +RGDI++LL+GDP VAK
Sbjct: 293 HDYVKKAIICLLLGGVERELENGSHIRGDINILLIGDPSVAK 334
>gi|11433475 minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin)
[Homo sapiens]
Length = 582
Score = 169 bits (424), Expect = 1e-40
Identities = 108/339 (31%), Positives = 179/339 (51%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + + ++ +I D+ + S+ +N+ L + + LA + E
Sbjct: 183 RLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKEN-RESLVVNYEDLAAREHVLAYFLPE 241
Query: 63 NPEECI-LAAEDAIQIILKEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + + E A++++L + + IH R +LP ++ + H+N+LI+ G
Sbjct: 242 APAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSG 301
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 302 VVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIY 361
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q RIQ+ P + G++PR D ILL D+VD+ PGD + + GI +
Sbjct: 362 QNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTAN 421
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F VI N++ ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 422 GFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHED 481
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G+ALALFGG P+ ++RGDI+VLL GDPG AK
Sbjct: 482 IKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAK 520
>sp|Q24849|MCM3_ENTHI DNA REPLICATION LICENSING FACTOR MCM3 >gi|1359633|emb|CAA66661.1|
(X98048) mini chromosome maintenance protein [Entamoeba
histolytica]
Length = 597
Score = 161 bits (403), Expect = 4e-38
Identities = 99/264 (37%), Positives = 152/264 (57%), Gaps = 38/264 (14%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAVV D T LEAGA+VLAD G +DE DKM+ +DR+ +HE +EQQT+++ KAGI
Sbjct: 263 TAAVVNDPDTNQRTLEAGAMVLADRGICCVDEFDKMSIEDRAAMHEVMEQQTVTVQKAGI 322
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+ + +++AAANP G ++ K E + P +L+SRFDLIF+++D E++D +++
Sbjct: 323 HTGIKCKMSILAAANPSNGNYDFKKSPMENLYFPESLLSRFDLIFIILDSSTEELDRKLS 382
Query: 914 RHILRV---------RRGESEV--------------VTPKIPHDLLRKYIAY----ARKN 946
+H+L++ +RG+ EV P L K Y + KN
Sbjct: 383 QHVLKMHRHFDALTEQRGDDEVNVLALVDAEREKIGDAPVYQDSLCMKEKNYLLINSLKN 442
Query: 947 V--------HPVISEEAMEEIEKYYVKMRKSVKKSSEE---EIKPIPITARQLEALIRLS 995
+ P +SE A E I YVK+R++ + + +IK +PITAR L++LIRL+
Sbjct: 443 MLLMLEISPTPSLSESASETIADAYVKLRENERLKRIKHNFKIKTLPITARALDSLIRLA 502
Query: 996 EAHARMRLSPIVTREDAREAIKLM 1019
EAHAR+R S + DA+ A++L+
Sbjct: 503 EAHARIRGSDTIDEIDAQVAVQLI 526
Score = 129 bits (321), Expect = 2e-28
Identities = 82/239 (34%), Positives = 131/239 (54%), Gaps = 23/239 (9%)
Query: 105 KEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVC--------KDCGHEMVVQQKPYEGF 156
+ I A + + + V+G++T+ ++I+P + +AV C +D H V+
Sbjct: 11 RNITASILQQKVAVQGIITKSSQIRPLLQTAVQFCPLDYSTHARDLSHADVM-------- 62
Query: 157 VAVKKCEKC-GSKNVQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTA 215
VK K K ++L+ S + +FQ +Q+ PE+ GQMPR + ILLD +VD
Sbjct: 63 --VKLSSKTPDGKPLELEPGLSTYKDFQTLVVQEMPESAPTGQMPRSVIVILLDQLVDKG 120
Query: 216 MPGDRVVVVGILRVVQEKREKVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKR 275
PGDRV++ G L+ + TFK V+E I + E EL T +++ I+++ K
Sbjct: 121 KPGDRVIINGTLKALAGPNHS-STFKVVLEAENINTLQSEGPEL--TEIDKENIKKVMKE 177
Query: 276 KDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
++ ++ SIAP+IYG+ +VKK I L L G P+ + +R+RGDIHV+L GDP AK
Sbjct: 178 ENPINLFSKSIAPSIYGHSDVKKAILLMLVGATPK-IRLRSRVRGDIHVMLCGDPSTAK 235
>gi|4758706 minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin);
cdc19; cyclin-like 1; mitotin [Homo sapiens]
>gi|7428555|pir||S42228 replication licensing factor
MCM2 - human >gi|468704|emb|CAA47749.1| (X67334)
polypeptide BM28 [Homo sapiens]
Length = 892
Score = 161 bits (402), Expect = 5e-38
Identities = 106/339 (31%), Positives = 176/339 (51%), Gaps = 8/339 (2%)
Query: 3 REEIIERFLRFLREYAEEGEEPLYIGKIKDLLAITPKRSIAINWMHLNSFDPELAEEVLE 62
R EI RF FLR + + ++ +I D+ + S+ +N+ L + + LA + E
Sbjct: 181 RLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKEN-RESLVVNYEDLAAREHVLAYFLPE 239
Query: 63 NPEECI-LAAEDAIQIILKEDIMREDVPR-IHARFYNLPKTLMVKEIGAEHINKLIQVEG 120
P E + + E A++++L + + IH R +LP ++ + H+N+LI+ G
Sbjct: 240 APAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSG 299
Query: 121 VVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKKCEKCGSKN-VQLDVEKSKF 179
VVT T + P +S + C C + + V C +C S ++++E++ +
Sbjct: 300 VVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIY 359
Query: 180 VNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVVQE----KRE 235
N+Q RIQ+ P + ++PR D ILL D+VD+ GD + + GI +
Sbjct: 360 QNYQRIRIQESPGKVAARRLPRSKDAILLADLVDSCNAGDEIELTGIYHNNYDGSLNTAN 419
Query: 236 KVPTFKKVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYRE 295
P F VI N++ ++ E+T E+ + I L+K + I + I SIAP+IYG+ +
Sbjct: 420 GFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHED 479
Query: 296 VKKGIALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
+K+G ALALFGG P+ ++RGDI+VLL GDPG AK
Sbjct: 480 IKRGPALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAK 518
Score = 154 bits (386), Expect = 4e-36
Identities = 92/219 (42%), Positives = 128/219 (58%), Gaps = 26/219 (11%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA V R + W LEAGALVLAD G LIDE DKMND+DR+ IHEA+EQQ+IS+SKAGI
Sbjct: 546 TAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI 605
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
+L AR TVIAAANP GR++ SE ++L ++SRFD++ V+ D D D +A
Sbjct: 606 VTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLA 665
Query: 914 RHIL--RVRRGES-------------EVVTPK------IPHDLLRKYIAYARKNVHPVIS 952
R ++ VR S E P +P ++L+KYI YA++ VHP ++
Sbjct: 666 RFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLN 725
Query: 953 EEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEAL 991
+ +++ K Y +RK + IPIT R +E++
Sbjct: 726 QMDQDKVAKMYSDLRKESMATGS-----IPITVRHIESM 759
>gb|AAC52018.1| (U63630) MCM4 [Homo sapiens]
Length = 712
Score = 159 bits (397), Expect = 2e-37
Identities = 85/189 (44%), Positives = 120/189 (62%), Gaps = 1/189 (0%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+VY+L G ++ V TA V++D T VL+ GALVL+D G IDE DKMN+
Sbjct: 522 YVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNE 581
Query: 832 KDRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLM 891
RSV+HE +EQQT+S++KAGI LNART+V+AAANP + ++N K E I LP TL+
Sbjct: 582 STRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLL 641
Query: 892 SRFDLIFVLVDEPDEKIDSEIARHILRV-RRGESEVVTPKIPHDLLRKYIAYARKNVHPV 950
SRFDLIF+L+D DE D +A H++ + + E + + +L+ YIAYA + P
Sbjct: 642 SRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPR 701
Query: 951 ISEEAMEEI 959
+SEEA + +
Sbjct: 702 LSEEASQAL 710
Score = 149 bits (372), Expect = 2e-34
Identities = 108/359 (30%), Positives = 188/359 (52%), Gaps = 33/359 (9%)
Query: 4 EEIIERFL-RFLREYAEEGE-------EPLYIGKIKDLLAITPKRSIAINWMHLNSFDPE 55
+E +RFL RF+ A+E E EPLY+ ++ ++ I + + +N H+ SFD
Sbjct: 163 KENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIG-EPFLNVNCEHIKSFDKN 221
Query: 56 LAEEVLENPEECILAAEDAIQIILKE---DIMREDVPRIHARFYNLPKTLMVKEIGAEHI 112
L +++ P+E I + A+ I + D + E +I R +N KT ++ + E I
Sbjct: 222 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEH--QIQVRPFNALKTKNMRNLNPEDI 279
Query: 113 NKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVAVKK-CEKCGSKN-V 170
++LI + G+V R +++ P + A F C+ C H V+ G +A C +C + + +
Sbjct: 280 DQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMD--RGRIAEPSVCGRCHTTHSM 337
Query: 171 QLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV 230
L +S F + QM ++Q+ PE + GQ P + +D+VD PGDRV V GI R V
Sbjct: 338 ALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAV 397
Query: 231 QEK-REKVPTFKKVIE-----VNYIEPVSKEIEELEITPEEE-------QKIRELAKRKD 277
+ +V K V + ++Y + +K + L+ E++ + ++EL+++ D
Sbjct: 398 PIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPD 457
Query: 278 IVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTR--LRGDIHVLLVGDPGVAK 334
I + + ++AP+IY + ++KKGI L LFGG + R R +I++LL GDPG +K
Sbjct: 458 IYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSK 516
>pir||S43199 cell division control protein CDC46 - human (fragment)
Length = 241
Score = 151 bits (378), Expect = 4e-35
Identities = 80/177 (45%), Positives = 120/177 (67%), Gaps = 4/177 (2%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TA+V+RD + +++E GA VLADGG IDE DKM + DR IHEA+EQQTIS++KAGI
Sbjct: 66 TASVMRDPSSRNFIMEGGAWVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGI 125
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
T TLN+R +V+AAAN GR++ K + I+ PT++SRFD+IF++ DE +E+ D +A
Sbjct: 126 TTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLA 184
Query: 914 RHILRVRRG---ESEVVTPKIPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMR 967
+H++ + +++ V +I L+K+IAY R P +S EA E+++ Y+ MR
Sbjct: 185 KHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMR 241
>pir||T41090 cdc21 protein - fission yeast (Schizosaccharomyces pombe)
(fragment) >gi|5748697|emb|CAB53089.1| (AL109957) cdc21
protein [Schizosaccharomyces pombe]
Length = 546
Score = 145 bits (362), Expect = 3e-33
Identities = 114/384 (29%), Positives = 196/384 (50%), Gaps = 62/384 (16%)
Query: 4 EEIIERFLRFLR--------EYAEE------GEEPLYIGKIKDLLAITPKRSIAINWMHL 49
+E I F FLR EY E E+ +YI ++++ I + ++ L
Sbjct: 167 QESIASFRGFLRGFKKKYRPEYRNELMPPPDAEQLVYIEALRNM-RIMGLEILNLDVQDL 225
Query: 50 NSFDP--ELAEEVLENPEECILAAEDAIQIIL--------KEDIMREDVPRIHA-RFYNL 98
+ P +L ++ P+E I + I+ ++ ED++ + +I+ R +NL
Sbjct: 226 KHYPPTKKLYHQLYSYPQEIIPIMDQTIKDVMLDLLGTNPPEDVLNDIELKIYKIRPFNL 285
Query: 99 PKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKDCGHEMVVQQKPYEGFVA 158
K + ++++ I+KLI ++G+V R T + P + A F C CGH + V+ G +A
Sbjct: 286 EKCINMRDLNPGDIDKLISIKGLVLRCTPVIPDMKQAFFRCSVCGHCVTVEID--RGRIA 343
Query: 159 VK-KC--EKCGSKN-VQLDVEKSKFVNFQMFRIQDRPETLKGGQMPRFIDGILLDDIVDT 214
KC E CG+ N +QL +S+F + Q+ ++Q+ P+ + GQ P + + D++VD+
Sbjct: 344 EPIKCPREVCGATNAMQLIHNRSEFADKQVIKLQETPDVVPDGQTPHSVSLCVYDELVDS 403
Query: 215 AMPGDRVVVVGILRVV--------------------------QEKREKVPTFKKVIEVNY 248
A GDR+ V GI R V Q+KR ++ T +E +
Sbjct: 404 ARAGDRIEVTGIFRCVPVRLNPRMRTVKSLFKTYVDVVHIKKQDKR-RLGTDPSTLESDI 462
Query: 249 IEPVSKEIEEL-EITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGG 307
E + +I+E+ +I+ EE +KI++++KR DI D + S+AP+IY +VKKG+ L LFGG
Sbjct: 463 AEDAALQIDEVRKISDEEVEKIQQVSKRDDIYDILSRSLAPSIYEMDDVKKGLLLQLFGG 522
Query: 308 VPRTLPDGT--RLRGDIHVLLVGD 329
++ G R RGDI++L+ GD
Sbjct: 523 TNKSFHKGASPRYRGDINILMCGD 546
>gi|6320803 component of DNA replication initiator complex; Mcm3p
[Saccharomyces cerevisiae]
>gi|126822|sp|P24279|MCM3_YEAST MINICHROMOSOME
MAINTENANCE PROTEIN 3 >gi|101441|pir||A36376 replication
licensing factor MCM3 [validated] - yeast
(Saccharomyces cerevisiae) >gi|3914|emb|CAA37616.1|
(X53540) Mcm3 product [Saccharomyces cerevisiae]
>gi|603647|gb|AAB65010.1| (U18779) Mcm3p [Saccharomyces
cerevisiae]
Length = 971
Score = 143 bits (356), Expect = 1e-32
Identities = 104/334 (31%), Positives = 158/334 (47%), Gaps = 40/334 (11%)
Query: 34 LAITPKRSIAINWMHLNSFDPELAEEVLENPEECILAAEDAIQIILKEDIMREDVPRIHA 93
L I P R I I+ L FD +L P I AE A+ + +DVP +A
Sbjct: 89 LNILPHR-IIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADS---MDDVPHPNA 144
Query: 94 RFYNL-------------PKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCK 140
+ L + + A+H+NKL+ VEG+VT+ + ++P + +V
Sbjct: 145 SAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAA 204
Query: 141 DCGHEMVVQQKPYEGFV----------AVKKCEKCGSKNVQLDVEKSKFVNFQMFRIQDR 190
G + Y A+ E + + S F++ Q +Q+
Sbjct: 205 KTGR---FHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEM 261
Query: 191 PETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILRVV------QEKREKVPTFKKVI 244
PE GQ+PR ID IL DD+VD PGDRV VVG+ + + Q + FK +I
Sbjct: 262 PEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLI 321
Query: 245 EVNYIEPVSKEIEELE----ITPEEEQKIRELAKRKDIVDAIVDSIAPAIYGYREVKKGI 300
N + P+ + +T + + I +L+K+KDI D + S+AP+IYG+ +KK I
Sbjct: 322 LGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAI 381
Query: 301 ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
L L GGV + L +G+ LRGDI++L+VGDP AK
Sbjct: 382 LLMLMGGVEKNLENGSHLRGDINILMVGDPSTAK 415
Score = 131 bits (327), Expect = 3e-29
Identities = 69/128 (53%), Positives = 89/128 (68%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
TAAV D TG LEAGA+VLAD G IDE DKM D DR IHE +EQQT++++KAGI
Sbjct: 443 TAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGI 502
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
TLNAR +VIAAANP G+++ + + I LP +L+SRFDL+FV+ D+ +E D I+
Sbjct: 503 HTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSIS 562
Query: 914 RHILRVRR 921
H+LR R
Sbjct: 563 EHVLRTHR 570
Score = 71.8 bits (173), Expect = 4e-11
Identities = 38/88 (43%), Positives = 56/88 (63%), Gaps = 6/88 (6%)
Query: 936 LRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEALIRLS 995
LRKY+ YA++ V P +++EA+ I K Y +R +++ K PITAR LE LIRL+
Sbjct: 656 LRKYVQYAKERVIPQLTQEAINVIVKNYTDLR------NDDNTKKSPITARTLETLIRLA 709
Query: 996 EAHARMRLSPIVTREDAREAIKLMEYTL 1023
AHA++RLS V + DA+ A L+ + L
Sbjct: 710 TAHAKVRLSKTVNKVDAKVAANLLRFAL 737
>gb|AAG37988.1|AF083323_1 (AF083323) DNA replication licensing factor MCM4 [Plasmodium
falciparum]
Length = 1005
Score = 141 bits (353), Expect = 3e-32
Identities = 83/237 (35%), Positives = 139/237 (58%), Gaps = 9/237 (3%)
Query: 680 ETLKSKGLSDVTIEIPEKLRRFIKCDRV--RYVDLVEMLSSMEGELKEEVMLLLSDVGDI 737
E L +G T E+ +K+ + K + R VD + G++K+ ++ L I
Sbjct: 489 EKLNEQGNLLFTTEVIQKMEQLSKDPNIYQRLVDSIAPSIYGRGDIKKGLLCQLFGGSKI 548
Query: 738 HEVIQERLK-EIGKILESDASWERIAEVEEVVRDGHVYDLTVEGSHSFIANGFVVHNTAA 796
+ + + EI +L D S + + +V+ L+ G ++ V TA
Sbjct: 549 TDKYNNKYRSEIHILLRGDPSTAKSQLLH------YVHKLSPRGIYTSGKGSSSVGLTAF 602
Query: 797 VVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGITAT 856
+ +D T ++LE+GA+VL+D G IDE DKM+D R+++HE +EQQT++++KAGI AT
Sbjct: 603 ISKDSETKEYILESGAVVLSDKGICCIDEFDKMDDSARAILHEVMEQQTVTIAKAGIVAT 662
Query: 857 LNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIA 913
LNART+++A+ANP R+++ K + E INLPP+L SRFDLI++++D+ +E D ++A
Sbjct: 663 LNARTSILASANPINSRYDKNKAVVENINLPPSLFSRFDLIYLVIDQANEDEDRKLA 719
Score = 116 bits (288), Expect = 1e-24
Identities = 98/367 (26%), Positives = 163/367 (43%), Gaps = 78/367 (21%)
Query: 40 RSIAINWMHLNSFDPELAEEVLENPEECILAAEDAIQ--------IILKEDIM------- 84
+S I+ H+ F+ +L + ++E P +CI + I ++L+ D
Sbjct: 212 KSFEIDLTHIFFFNKKLYKLIIEYPSDCISEIDKIISTKYNSLLALVLEGDTRSSSSDKY 271
Query: 85 -----REDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVC 139
++D R+ RF+N +++G I L+ V+GV+ R + I P ++ A F C
Sbjct: 272 PLSSTKQDYCRV--RFFNKKHKDTPRKLGPNQIETLVCVKGVIIRCSNIIPEMTMAAFKC 329
Query: 140 -----------KDCGHEM---VVQQKPYEGFVAVKKCEKCGSKNV-QLDVEKSKFVNFQM 184
+ C E+ V+Q + E C C +KN +L F + Q+
Sbjct: 330 TSKKRIGVNNYEKCNEEVYEHVIQGEVQEPVT----CSNCNNKNTFELWHNNCCFSSKQL 385
Query: 185 FRIQDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGILR---------------- 228
++ + E LK G+ P+ I DD++D PGD V + GIL+
Sbjct: 386 IKLSEVTEHLKQGETPQSISIYAYDDLIDYTKPGDTVELTGILKASPVRLNPRSRCYNSV 445
Query: 229 ---------VVQEKREKVP------TFKKVIEVNYIEPVSKEIEELE------ITPEEEQ 267
+ +E ++K+ T +++ N V + E+L T E Q
Sbjct: 446 HRTYINVIHIKKENKQKMKLTEQNDTANIILKRNEDGTVEENFEKLNEQGNLLFTTEVIQ 505
Query: 268 KIRELAKRKDIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVLLV 327
K+ +L+K +I +VDSIAP+IYG ++KKG+ LFGG T + R +IH+LL
Sbjct: 506 KMEQLSKDPNIYQRLVDSIAPSIYGRGDIKKGLLCQLFGGSKITDKYNNKYRSEIHILLR 565
Query: 328 GDPGVAK 334
GDP AK
Sbjct: 566 GDPSTAK 572
Score = 76.9 bits (186), Expect = 1e-12
Identities = 48/129 (37%), Positives = 76/129 (58%), Gaps = 7/129 (5%)
Query: 931 IPHDLLRKYIAYARKNVHPVISEEAMEEIEKYYVKMRKSVKKSSEEEIKPIPITARQLEA 990
I + L YIAY R +P+IS E+ + I + Y+KMR +E K + RQLE
Sbjct: 822 IDSNTLALYIAYCRITCNPIISLESKKIIIEEYIKMR------CKEGTKSPTASPRQLEG 875
Query: 991 LIRLSEAHARMRLSPIVTREDAREAIKLMEYTLRQIAVDE-TGQIDVTILEVGQSARKLS 1049
L+RLS++ A+M+L +V+ E+A EA++LM Q +D +G+ID + +GQ+++
Sbjct: 876 LVRLSQSLAKMKLKRVVSPEEANEAVRLMNIATFQSLIDPLSGRIDFDQVNLGQTSQHKK 935
Query: 1050 KVERILDII 1058
K + I DII
Sbjct: 936 KSDLIKDII 944
>emb|CAB59865.1| (AL132763) possible DNA replication licensing factor MCM4
[Leishmania major]
Length = 985
Score = 139 bits (348), Expect = 1e-31
Identities = 72/145 (49%), Positives = 98/145 (66%)
Query: 773 VYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDK 832
V+++ G ++ V TA VV+D TG VLE GALVL+D G IDE DKMN+
Sbjct: 548 VHEIAPRGVYTSGKGSSSVGLTAFVVQDSDTGELVLEPGALVLSDRGLCCIDEFDKMNEA 607
Query: 833 DRSVIHEALEQQTISLSKAGITATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMS 892
RSV+HE +EQQT+S++KAGI A LNART+++AAANPK ++N + E + + PTL+S
Sbjct: 608 TRSVLHEVMEQQTLSIAKAGIIAQLNARTSILAAANPKDSQWNAQLNVVENLQIEPTLLS 667
Query: 893 RFDLIFVLVDEPDEKIDSEIARHIL 917
RFDLIF+L+D D D +A H+L
Sbjct: 668 RFDLIFLLLDCHDSVEDRRLAAHVL 692
Score = 110 bits (272), Expect = 1e-22
Identities = 90/373 (24%), Positives = 155/373 (41%), Gaps = 68/373 (18%)
Query: 30 IKDLLAI--TPKRSIAINWMHLNSFDPELAEEVLENPEECIL---AAEDAIQ---IILKE 81
+K+LL + + ++ +++ L P L + + +P EC+ A D + ++L+
Sbjct: 169 LKELLRMHMQGRSTLEVDFTWLQRVAPRLYVQTVHHPTECLQMMSAVADEVYRDVLLLRH 228
Query: 82 DIMREDVPRIHARFYNLPKTLMVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVFVCKD 141
I + I LP +K++ +HI +L+ ++G+V RV++I P + A F C +
Sbjct: 229 GIEVAEDVLITVAAKKLPSMWTLKQLSPQHIEQLLSIKGMVIRVSKIVPEIRVACFQCWN 288
Query: 142 CGHEMVVQQKPYEGFVAVKKCEKCGSK-NVQLDVEKSKFVNFQMFRIQDRPETLKGGQMP 200
C ++ +C CG + +L S + + Q+ ++Q+ PE + G+ P
Sbjct: 289 CQYQERSVSGDKGRIFEPTRCAHCGKTYSFKLQHNLSLYEDKQLIKVQESPEHVADGETP 348
Query: 201 RFIDGILLDDIVDTAMPGDRVVVVGILRVVQEKREKVPTFKKVIEVNYIEPVSKEIEELE 260
I ++ +VD +PGDRV+V G+ R + K I +I+ V E+
Sbjct: 349 ISIGVVVYGSMVDAVVPGDRVIVTGVYRSTPIRLNANTRIIKSIFATHIDAVHIELVRAT 408
Query: 261 ITPEEEQK--------------------------------------------IRELAKRK 276
E K LA R
Sbjct: 409 RASEAGAKKGCFANGNATGTGLHVSTPTLATAKNAEGDLSSAVLMDTARLDMFHSLAHRP 468
Query: 277 DIVDAIVDSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRL---------------RGD 321
DI D ++ S A I+G+ +VK+GI LFGG +T R+ R +
Sbjct: 469 DIYDVLLHSFARTIWGHDDVKRGILAQLFGGTAKTFVFSERIGSGAAATTSSNSAVFRSE 528
Query: 322 IHVLLVGDPGVAK 334
++VLL GDPGVAK
Sbjct: 529 LNVLLCGDPGVAK 541
>emb|CAB89596.1| (AL354513) possible putative minichromosome maintenance protein
[Leishmania major]
Length = 993
Score = 124 bits (308), Expect = 6e-27
Identities = 81/280 (28%), Positives = 142/280 (49%), Gaps = 52/280 (18%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
T + RD +G EAGA+V DGG +DE+DK + ++++ E +EQ+T+SL+KAG+
Sbjct: 617 TMTLTRDPVSGETTFEAGAVVHGDGGITCLDEIDKGVQEHKALL-EVMEQETVSLAKAGM 675
Query: 854 TATLNARTTVIAAANPKQGRFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSE-- 911
++ RT+++AA NP GRF+ K ++ +NL P L+SRFD+I L + +++
Sbjct: 676 IFSMPVRTSILAAGNPIGGRFDVRKSLAANVNLSPALLSRFDIIACLRNPHGSSGNAQQA 735
Query: 912 IARHILRVR-----------------RGESEVVTPKIPHDLLRKYIAYARKNVHPVISEE 954
+ H+L+ RG P +P L+++++ + R P + E
Sbjct: 736 LTDHVLQWHRRAPAGGDGGEGCNGGGRGRGHGAGP-LPLPLVQRFLLFCRSQCQPTLCRE 794
Query: 955 AMEEIEKYYVKMRKSVKK----------------------SSEEEIKPIP---------I 983
A + ++ +Y+ R+ + + S P+P +
Sbjct: 795 ACDVLQTHYLAQRQHLPQPQYGFEHGATASCAGSAAGHLSDSGSVSGPLPRAAMGLEATV 854
Query: 984 TARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYTL 1023
T R L+ALIR++EA A++ L +VTREDA A++L++ L
Sbjct: 855 TPRYLQALIRVAEARAKLELRHVVTREDAEYAVQLLQSCL 894
>gi|10954504 M. jannaschii predicted coding region MJECL13 [Methanococcus
jannaschii] >gi|2497832|sp|Q60275|YZ13_METJA HYPOTHETICAL
MCM-TYPE PROTEIN MJECL13 >gi|2129030|pir||E64511
replication licensing factor MCM-type homolog MJECL13 -
Methanococcus jannaschii plasmid pURB800
>gi|1522653|gb|AAC37086.1| (L77118) M. jannaschii
predicted coding region MJECL13 [Methanococcus
jannaschii]
Length = 602
Score = 101 bits (250), Expect = 4e-20
Identities = 77/258 (29%), Positives = 135/258 (51%), Gaps = 31/258 (12%)
Query: 799 RDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGITATLN 858
R G + G ++ G ID+ ++ N+K + + EA E+ ++ +K G +
Sbjct: 354 RSNILGKFYTVCGGVIPRTLGVLCIDDFNE-NNKLSTKLSEAFERNVLTTNK-GSFYCVP 411
Query: 859 ARTTVIAAANPKQG--RFNRMKRISEQINLPPTLMSRFDLIFVLVDEPDEKIDSEIARHI 916
A + + A PK +F++ K I +QI + L+ FDLIF + D PD+ D E+A++I
Sbjct: 412 AECSFLCACYPKTKFRKFDQKKSIIKQIGISSILLKNFDLIFPIRDIPDKDRDEEVAKYI 471
Query: 917 -LRVRRGESEVVTP-------------KIPHDLLRKYIAYARKNVHPVISEEAMEEIEKY 962
L+ ++E + KI + L+KY+ Y+R+ + P I++E +E+I +
Sbjct: 472 FLKYINSDNEEIEGYDYVFVDVGGEKIKIDFEFLKKYVVYSRQ-ITPKITDEVIEKISNW 530
Query: 963 YVKMRKSVKKSSEEEIKPIPITARQLEALIRLSEAHARMRLSPIVTREDAREAIKLMEYT 1022
Y +MRK+ ITA+QL +I+LS A AR +L V +D +EAI ++ +
Sbjct: 531 YDEMRKNHY-----------ITAKQLNTVIKLSIAVARAKLKECVDEDDVKEAIDIIMHY 579
Query: 1023 LRQIAVD-ETGQIDVTIL 1039
L+Q+ + + G IDV +L
Sbjct: 580 LKQVVYNPKKGIIDVILL 597
>gb|AAD19787.1| (AC006528) putative DNA replication licensing factor [Arabidopsis
thaliana]
Length = 610
Score = 95.2 bits (233), Expect = 4e-18
Identities = 83/334 (24%), Positives = 143/334 (41%), Gaps = 48/334 (14%)
Query: 44 INWMHLNSFDPELAEEVLENPEECILAAEDAIQIILKEDIMREDVPR-----------IH 92
I + L +P LA +V +PE + +D+ IL I E + + IH
Sbjct: 43 IEYAELVDDNPSLARQVFSDPEHYLRQFDDSA--ILAHKIALEHMKKFEEKIGIEKRFIH 100
Query: 93 ARFYNLPKTL---------------MVKEIGAEHINKLIQVEGVVTRVTEIKPFVSSAVF 137
R L + + +H L+ ++G V R +K + ++
Sbjct: 101 VRINTSGSPLERSPADFDFDTETFPSIGRVRVKHRGILMMLKGTVIRSGAVKMYEGEKMY 160
Query: 138 VCKDCGHEMVV----------QQKPYEGFVAVKKCEKCGSKNVQLDVEKSKFVNFQMFRI 187
C+ C H + + P+ K CE V V + ++Q +I
Sbjct: 161 RCRKCKHMFPIFPELESINSIVKPPFCPSQRSKACEGTNFDPVDDTVTRH---DYQEIKI 217
Query: 188 QDRPETLKGGQMPRFIDGILLDDIVDTAMPGDRVVVVGIL--RVVQEKREKVPTFKKVIE 245
Q+ + L G +PR I +L DD+VD GD VVV GIL + + ++ + ++
Sbjct: 218 QENTQVLGVGVIPRSILVVLKDDLVDNVKAGDDVVVSGILTSKWSHDLKDVRCDLEPMLI 277
Query: 246 VNYIEPVSKEIEELEITPEEEQKIRELAKR-KDIV----DAIVDSIAPAIYGYREVKKGI 300
N++ ++ E++I+ + +K + +D +AI+ I P ++G VK +
Sbjct: 278 ANHVRRTNELKSEIDISDDLIEKFKNFWSHFRDTPLKGRNAILRGICPQVFGLFTVKLAV 337
Query: 301 ALALFGGVPRTLPDGTRLRGDIHVLLVGDPGVAK 334
AL L GGV GT++RG+ H+LL+GDPG K
Sbjct: 338 ALTLIGGVQHVDASGTKVRGESHLLLIGDPGTGK 371
Score = 70.6 bits (170), Expect = 9e-11
Identities = 39/81 (48%), Positives = 51/81 (62%), Gaps = 4/81 (4%)
Query: 794 TAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMNDKDRSVIHEALEQQTISLSKAGI 853
T V+D G W+LEAGALVLADGG IDE D M + DR+ IHEA+EQQ+IS++K I
Sbjct: 399 TVTAVKDG--GEWMLEAGALVLADGGLCCIDEFDSMREHDRATIHEAMEQQSISVAK--I 454
Query: 854 TATLNARTTVIAAANPKQGRF 874
LN + + P+ +F
Sbjct: 455 QKILNGMQLYLLTSLPRYIQF 475
>pir||H71450 probable DNA repair protein - Pyrococcus horikoshii
>gi|3256652|dbj|BAA29335.1| (AP000001) 529aa long
hypothetical DNA repair protein [Pyrococcus horikoshii]
Length = 529
Score = 89.3 bits (218), Expect = 2e-16
Identities = 79/326 (24%), Positives = 146/326 (44%), Gaps = 66/326 (20%)
Query: 242 KVIEVNYIEPVSKEIEELEITPEEEQKIRELAKRKDI------------------VDAIV 283
+V+E++ IE + E+EE T ++++K +E+ +D+ ++AI
Sbjct: 12 EVVEIDEIEGLGLELEEESTTSKKKKKEKEIKSIEDLPGVGPATAEKLREAGFDTLEAIA 71
Query: 284 DSIAPAIYGYREVKKGIALALFGGVPRTLPDGTRLRGDIHVL------------------ 325
+ + + +G AL + + GT +R D ++
Sbjct: 72 VASPIELKEVAGISEGAALKIIQAARKAANLGTFMRADEYLKKRESIGRISTGSKSLDKL 131
Query: 326 ------------LVGDPGVAKCVDYETEVVLGNGERKKIGEIVERAIEEAEKNGKLGRVD 373
+ G+ G KC +TEV N + I E + A NG+L D
Sbjct: 132 LGGGIETQAITEVFGEFGSGKCFARDTEVYYENDTVPHMESIEEMYSKYASMNGELP-FD 190
Query: 374 DGFYAPID-IEVYSLDLETLKVRKARANIAWKRTAPKKMMLVKTRGGKRIRVTPTHPFFV 432
+G+ P+D + VY+LD+ + +++K RA+ ++ +K++ +K G ++VTP+HP +
Sbjct: 191 NGYAVPLDNVFVYTLDIASGEIKKTRASYIYREKV-EKLIEIKLSSGYSLKVTPSHPVLL 249
Query: 433 LEEG----KVAMRKARDLEEGNKIATIEGLSVSWDEV-------AEILEYEPKDPWVYDL 481
+G A K D+ G + + +S E+ I++Y + WVYDL
Sbjct: 250 FRDGLQWVPAAEVKPGDVVVGVREEVLRRRIISKGELEFHEVSSVRIIDY---NNWVYDL 306
Query: 482 QVPGYHNFLA-NGIFVHNSQLLRYIA 506
+P HNF+A NG+ +HN+QL +A
Sbjct: 307 VIPETHNFIAPNGLVLHNTQLAHTLA 332
>sp|Q58446|RPA2_METJA DNA-DIRECTED RNA POLYMERASE SUBUNIT A" >gi|2127865|pir||B64430
DNA-directed RNA polymerase (EC 2.7.7.6) subunit A''
(intein-containing) - Methanococcus jannaschii
>gi|1591697|gb|AAB99047.1| (U67547) DNA-directed RNA
polymerase, subunit A'' (rpoA2) [Methanococcus
jannaschii]
Length = 859
Score = 89.3 bits (218), Expect = 2e-16
Identities = 132/582 (22%), Positives = 240/582 (40%), Gaps = 73/582 (12%)
Query: 249 IEPVSKEIEELEITPE-EEQKIRELAKRKDIVDAIVDSIAPAIYG-YREVKKGIALALFG 306
+E + ++IE L+I +++ +L+K KD+ + +VD I + YR
Sbjct: 3 MEALKQKIEGLDIPQSLKDELFEKLSKEKDLTEEMVDEIIDEVVNAYR------------ 50
Query: 307 GVPRTLPDGTRLRGDIHVLLVGDPGVAKCVDYETEVVLGNGERKK---IGEIVERAIEEA 363
+ L + G + +G+PG + YE ++++ GE K IG++V+ IE
Sbjct: 51 ---KALVEPYEAVGIVAAQSIGEPGTQMSLPYEEKIIIKEGEFIKPVEIGKLVDEMIERF 107
Query: 364 --EKNGKLGRVDDGFYAPIDIEVYSLDLETLKVRKARANIAWKRTAPKKMMLVKTRGGKR 421
EK G D PIDI SLD + KV R + K++ +KT+ G+
Sbjct: 108 GFEKIGNSEVCD----LPIDIYALSLDQDE-KVHWKRIISCIRHKHNGKLIKIKTKSGRE 162
Query: 422 IRVTPTHPFFVLEEGKVAMRKARDLEEGNKIATIEGLSVSWDEVAEILEYEPKDPWVYDL 481
I TP H F + ++ K+ K +L+ G++I ++ + + E I +Y +
Sbjct: 163 ITATPYHSFVIRKDNKIIPVKGSELKIGDRIPVVKHIPANCVEAINISDYVSG-----NY 217
Query: 482 QVPGYHNFLA---NGIFVHNSQLLRYIANLAPRAIYTSGKSSSAAGLCVAPETLIITENG 538
V +N +A NG + N+ L Y G + + LI+
Sbjct: 218 VVDNINNKIAPKINGKSIPNNIKLDYDFGYFIGIYLAEGSVTKYFVSISNVDELIL---- 273
Query: 539 TKEIGEVVERWMKELGEIEYDDGIS-------YSPAFEKVASLNGGKVKMLPVRR-VWKL 590
+I ++ GE + ++G + YS + S G + V+
Sbjct: 274 -NKIRAFADKLGLNYGEYDNNNGFAESHDIRIYSSTLAEFLSNFGTSSNTKKIAEFVFGA 332
Query: 591 RSPGKMIKIRSESGKQITVTPETKLLTIIDGSLEWVE--ARKLKKGNYVAVVNKERS--- 645
IR V + K++ + S E ++ A L + N ++ K ++
Sbjct: 333 NKEFVRGLIRGYFDGDGNVNADRKVIRVTSNSKELIDGIAILLARFNIFSIKTKTKNQFV 392
Query: 646 -IVPIGDFLAKLLKFYGVELNLNEAVERDQARKLLETLKSKGLSDVTIEIPEKLRRFIKC 704
I+P + K + E+N + ++ + +L+ +L D IP K
Sbjct: 393 LIIP-----HRYAKKFHEEINFSVEKKKSELERLVSSLNDDKTYDSIDMIPSIGDALTKL 447
Query: 705 -DRVRYVDLVEMLSSMEGELKEEVMLLLSDVGDIHEVIQER------LKE---IGKILES 754
++V Y ++ L E + K L + I E+ ++ LKE + K +ES
Sbjct: 448 GEKVDYPKVI--LKKFERKQKIGRATLQRHLRRIEELAVKKGVNILALKEYWLLKKAVES 505
Query: 755 DASWERIAEVEEVVRD-GHVYDLTVEGSHSFIA-NGFVVHNT 794
D W+ I ++EE+ D +VYD++VEG +F +G + HNT
Sbjct: 506 DVIWDEIVKIEEISCDKKYVYDISVEGLETFTTFDGVLTHNT 547
>gb|AAC36509.1| (U89402) cdc21 [Mus musculus]
Length = 100
Score = 75.7 bits (183), Expect = 3e-12
Identities = 39/82 (47%), Positives = 53/82 (64%)
Query: 772 HVYDLTVEGSHSFIANGFVVHNTAAVVRDEFTGGWVLEAGALVLADGGYALIDELDKMND 831
+VY+L G ++ V TA V++D T VL+ GALVL+D G DE DKMN+
Sbjct: 19 YVYNLVPRGRYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCTDEFDKMNE 78
Query: 832 KDRSVIHEALEQQTISLSKAGI 853
RSV+HE +EQQT+S++KAGI
Sbjct: 79 STRSVLHEVMEQQTLSIAKAGI 100
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.317 0.137 0.382
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 401240877
Number of Sequences: 2977
Number of extensions: 17412098
Number of successful extensions: 62160
Number of sequences better than 1.0e-10: 131
Number of HSP's better than 0.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 61147
Number of HSP's gapped (non-prelim): 454
length of query: 1112
length of database: 189,106,746
effective HSP length: 62
effective length of query: 1050
effective length of database: 152,000,552
effective search space: 159600579600
effective search space used: 159600579600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 170 (70.6 bits)