BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2382 (tdh) DE:THREONINE 3-DEHYDROGENASE (EC 1.1.1.103).
(348 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75049 L-threonine 3-dehydrogenase (EC 1.1.1.103) PAB2382 -... 712 0.0
pir||H71110 probable dehydrogenase - Pyrococcus horikoshii >gi|3... 707 0.0
sp|O31776|TDH_BACSU THREONINE 3-DEHYDROGENASE >gi|7427644|pir||C... 349 3e-95
pir||B82405 threonine 3-dehydrogenase VCA0885 [imported] - Vibri... 310 1e-83
sp|Q52998|TDH_RHIME THREONINE 3-DEHYDROGENASE 303 2e-81
sp|P07913|TDH_ECOLI THREONINE 3-DEHYDROGENASE >gi|65905|pir||DEE... 302 4e-81
pir||A75371 threonine 3-dehydrogenase - Deinococcus radiodurans ... 301 7e-81
sp|O34268|TDH_XANCP THREONINE 3-DEHYDROGENASE >gi|7427643|pir||J... 295 6e-79
emb|CAB71246.1| (AL138598) threonine 3-dehydrogenase. [Streptomy... 279 3e-74
gb|AAB70823.1| (AF019635) benzyl alcohol dehydrogenase [Pseudomo... 263 2e-69
gb|AAC44788.1| (U20269) XylW hypothetical protein [Pseudomonas p... 263 2e-69
gb|AAA84986.1| (U41301) TmbW [Pseudomonas putida] 263 2e-69
gb|AAC38358.1| (AF043544) putative alcohol dehydrogenase NtnW [P... 261 9e-69
dbj|BAA09660.1| (D63341) benzyl alcohol dehydrogenase II [Pseudo... 258 8e-68
dbj|BAA75341.1| (AB011837) sorbitol dehydrogenase [Bacillus halo... 197 1e-49
sp|Q06004|DHSO_BACSU SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROG... 186 3e-46
pir||F69852 L-iditol 2-dehydrogenase (EC 1.1.1.14) homolog yjmD ... 176 2e-43
dbj|BAA95897.1| (AB042810) NAD-dependent sorbitol dehydrogenase ... 176 2e-43
dbj|BAA36481.2| (AB016256) NAD-dependent sorbitol dehydrogenase ... 176 4e-43
sp|Q57517|Y053_HAEIN HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENAS... 175 9e-43
gb|AAA88523.1| (L47288) threonine dehydrogenase [Sinorhizobium m... 173 2e-42
pir||T23889 hypothetical protein R04B5.5 - Caenorhabditis elegan... 171 1e-41
dbj|BAA94084.1| (AB025969) NAD-dependent sorbitol dehydrogenase ... 170 2e-41
pir||C83128 2,3-butanediol dehydrogenase PA4153 [imported] - Pse... 169 5e-41
gb|AAB58982.1| (L35343) 2,3-butanediol dehydrogenase [Pseudomona... 167 2e-40
sp|P38105|RSPB_ECOLI STARVATION SENSING PROTEIN RSPB >gi|2126057... 167 2e-40
dbj|BAB07668.1| (AP001520) L-iditol 2-dehydrogenase [Bacillus ha... 167 2e-40
dbj|BAB11045.1| (AB015478) sorbitol dehydrogenase-like protein [... 162 7e-39
pir||T23890 hypothetical protein R04B5.6 - Caenorhabditis elegan... 159 6e-38
gi|8394334 sorbitol dehydrogenase [Rattus norvegicus] >gi|57223|... 159 6e-38
sp|P27867|DHSO_RAT SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGEN... 159 6e-38
pir||S38363 L-iditol 2-dehydrogenase (EC 1.1.1.14) precursor - r... 158 8e-38
sp|P39400|YJJN_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENAS... 157 1e-37
emb|CAB61801.1| (AL133236) putative dehydrogenase [Streptomyces ... 157 1e-37
gb|AAC24597.1| (AF072541) xylitol dehydrogenase; XDH [Candida sp... 157 2e-37
pir||B72381 alcohol dehydrogenase, zinc-containing - Thermotoga ... 155 7e-37
gb|AAK43330.1| Sorbitol dehydrogenase [Sulfolobus solfataricus] 154 2e-36
pir||G70862 probable adhE2 protein - Mycobacterium tuberculosis ... 151 1e-35
sp|P22144|XYL2_PICST D-XYLULOSE REDUCTASE (XYLITOL DEHYDROGENASE... 151 1e-35
gb|AAD02817.1| (AF067126) NADP(H)-dependent ketose reductase [Be... 151 1e-35
sp|P77539|YDJL_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENAS... 151 1e-35
pir||T36961 probable zinc-containing dehydrogenase - Streptomyce... 151 1e-35
dbj|BAB03906.1| (AP001507) sorbitol dehydrogenase [Bacillus halo... 151 1e-35
sp|Q64442|DHSO_MOUSE SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROG... 150 2e-35
prf||2121217A sorbitol dehydrogenase [Homo sapiens] 150 2e-35
sp|Q00796|DHSO_HUMAN SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROG... 150 2e-35
pir||H81925 probable alcohol dehydrogenase (EC 1.1.1.-) NMA0808 ... 150 2e-35
gi|4507155 sorbitol dehydrogenase [Homo sapiens] >gi|1082564|pir... 149 5e-35
gi|11432526 sorbitol dehydrogenase [Homo sapiens] 148 1e-34
pir||E81178 probable alcohol dehydrogenase (EC 1.1.1.-) NMB0604 ... 148 1e-34
pir||H69789 probable alcohol dehydrogenase (EC 1.1.1.-) ydjL [si... 148 1e-34
sp|P77280|YDJJ_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENAS... 147 2e-34
sp|P07846|DHSO_SHEEP SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROG... 147 2e-34
pir||S10065 L-iditol 2-dehydrogenase (EC 1.1.1.14) - sheep (tent... 147 2e-34
gb|AAB69288.1| (AF010494) sorbitol dehydrogenase [Callithrix sp.] 146 3e-34
emb|CAC14943.1| (AL449216) putative oxidoreductase [Streptomyces... 146 3e-34
pir||T36915 probable zinc-binding dehydrogenase - Streptomyces c... 145 1e-33
pir||B83133 probable alcohol dehydrogenase (Zn-dependent) PA4097... 143 2e-33
sp|P50381|ADH3_SULSO NAD-DEPENDENT ALCOHOL DEHYDROGENASE >gi|108... 143 3e-33
gb|AAK42665.1| Alcohol dehydrogenase (Zn containing) (adh-10) [S... 141 9e-33
sp|P39462|ADH1_SULSO NAD-DEPENDENT ALCOHOL DEHYDROGENASE >gi|322... 141 9e-33
gb|AAK42584.1| Alcohol dehydrogenase (Zn containing) (adh-7) [Su... 141 2e-32
sp|P80094|FADH_AMYME NAD/MYCOTHIOL-DEPENDENT FORMALDEHYDE DEHYDR... 140 2e-32
pir||T36783 probable zinc-binding alcohol dehydrogenase - Strept... 140 2e-32
sp|Q02912|DHSO_BOMMO SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROG... 140 3e-32
sp|P42327|ADH2_BACST ALCOHOL DEHYDROGENASE (ADH) >gi|1075811|pir... 139 3e-32
gb|AAC32671.1| (U61983) benzyl alcohol dehydrogenase [Acinetobac... 139 3e-32
dbj|BAB10455.1| (AB005234) alcohol dehydrogenase-like protein [A... 139 3e-32
gb|AAG10028.1|AF282240_12 (AF282240) alcohol dehydrogenase [Acin... 139 6e-32
pir||C81088 alcohol dehydrogenase, zinc-containing NMB1395 [impo... 138 8e-32
gi|6322619 sorbitol-induced sorbitol dehydrogenase; Sor1p [Sacch... 138 1e-31
gi|6319955 Ydl246cp [Saccharomyces cerevisiae] >gi|2117435|pir||... 138 1e-31
dbj|BAA75343.1| (AB011837) sorbitol dehydrogenase [Bacillus halo... 137 2e-31
pir||C72533 probable alcohol dehydrogenase APE2239 - Aeropyrum p... 137 2e-31
gi|6323099 Ylr070cp [Saccharomyces cerevisiae] >gi|2117438|pir||... 136 3e-31
sp|P25406|ADHB_UROHA ALCOHOL DEHYDROGENASE I-B (ADH IB) >gi|2134... 136 5e-31
sp|P36624|DHSO_SCHPO PUTATIVE SORBITOL DEHYDROGENASE (L-IDITOL 2... 135 7e-31
sp|O31186|ADHA_RHIME ALCOHOL DEHYDROGENASE >gi|2645697|gb|AAB874... 135 7e-31
pir||T39670 probable sorbitol dehydrogenase - fission yeast (Sc... 135 7e-31
pir||G72376 alcohol dehydrogenase, zinc-containing - Thermotoga ... 134 1e-30
gb|AAK41467.1| Alcohol dehydrogenase (Zn containing) (adh-3) [Su... 134 2e-30
pir||S49084 NAD dependent galactitol-1-phosphate dehydrogenase (... 134 2e-30
sp|P25405|ADHA_UROHA ALCOHOL DEHYDROGENASE I-A (ADH IA) >gi|2134... 133 3e-30
gi|6319257 Yal061wp [Saccharomyces cerevisiae] >gi|731294|sp|P39... 132 4e-30
sp|P37190|GATD_ECOLI GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE >gi|... 132 4e-30
emb|CAC11970.1| (AL445065) alcohol dehydrogenase related protein... 132 4e-30
prf||2113201F carbohydrate phosphotransferase II [Escherichia coli] 132 6e-30
gb|AAD00903.1| (AF002213) sorbitol dehydrogenase [Drosophila mel... 132 6e-30
gb|AAD34026.1|AF150928_4 (AF150928) AreB [Acinetobacter sp. ADP1] 132 6e-30
pir||B83191 alcohol dehydrogenase class III PA3629 [imported] - ... 132 6e-30
gb|AAD00902.1| (AF002212) sorbitol dehydrogenase [Drosophila mel... 132 7e-30
pir||T36806 probable alcohol dehydrogenase (zinc-binding) - Stre... 131 1e-29
gi|6319258 Yal060wp [Saccharomyces cerevisiae] >gi|731293|sp|P39... 131 2e-29
gb|AAK42635.1| Alcohol dehydrogenase (Zn containing) (adh-9) [Su... 129 4e-29
pir||H81186 alcohol dehydrogenase, propanol-preferring NMB0546 [... 129 4e-29
gb|AAK40795.1| Alcohol dehydrogenase (Zn containing) (adh-1) [Su... 128 9e-29
sp|P14940|ADH_ALCEU ALCOHOL DEHYDROGENASE >gi|78184|pir||A30196 ... 128 9e-29
sp|P41681|ADH2_PERMA ALCOHOL DEHYDROGENASE 2 >gi|1364000|pir||B4... 128 1e-28
sp|P42328|ADH3_BACST ALCOHOL DEHYDROGENASE (ADH-HT) >gi|628989|p... 128 1e-28
sp|P12311|ADH1_BACST ALCOHOL DEHYDROGENASE (ADH-T) >gi|282375|pi... 127 2e-28
pir||H81915 probable alcohol dehydrogenase (EC 1.1.1.1) NMA0725 ... 127 2e-28
sp|P80512|ADH1_NAJNA ALCOHOL DEHYDROGENASE 1 >gi|2134233|pir||S6... 127 3e-28
sp|P77316|YBDR_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENAS... 127 3e-28
pir||A82968 alcohol dehydrogenase PA5427 [imported] - Pseudomona... 125 6e-28
gb|AAK41859.1| Alcohol dehydrogenase (Zn containing) (adh-5) [Su... 125 1e-27
gb|AAC04779.1| (AF036920) aryl-alcohol dehydrogenase homolog [Rh... 124 1e-27
pir||A83381 alcohol dehydrogenase (Zn-dependent) PA2119 [importe... 124 2e-27
sp|P77360|YPHC_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENAS... 124 2e-27
pir||H65031 hypothetical protein b2545 - Escherichia coli (strai... 124 2e-27
sp|P39849|XYLB_PSEPU ARYL-ALCOHOL DEHYDROGENASE (BENZYL ALCOHOL ... 124 2e-27
gb|AAA26024.1| (M94184) xylB [Pseudomonas putida] 124 2e-27
pir||T35422 probable zinc-binding alcohol dehydrogenase - Strept... 123 3e-27
emb|CAB64351.1| (AJ243941) putative formaldehyde dehydrogenase (... 123 3e-27
sp|P22797|ADH1_RANPE ALCOHOL DEHYDROGENASE, MAJOR >gi|104315|pir... 122 8e-27
emb|CAB61162.1| (AL132973) putative Zinc-containing dehydrogenas... 120 2e-26
sp|P00332|ADH_SCHPO ALCOHOL DEHYDROGENASE >gi|65898|pir||DEZPA a... 119 4e-26
pir||T40962 alcohol dehydrogenase - fission yeast (Schizosacchar... 119 4e-26
emb|CAA07791.1| (AJ007958) dehydrogenase [Thiobacillus sp.] 119 4e-26
emb|CAC11883.1| (AL445065) sorbitol dehydrogenase related protei... 119 4e-26
pir||D70517 hypothetical protein Rv1895 - Mycobacterium tubercul... 119 6e-26
pir||E72597 probable alcohol dehydrogenase APE1245 - Aeropyrum p... 118 7e-26
pir||C70418 probable alcohol dehydrogenase (EC 1.1.1.-) - Aquife... 118 1e-25
gi|4501939 class V alcohol dehydrogenase 6; aldehyde reductase [... 118 1e-25
pir||T44975 dehydrogenase [imported] - Haloferax volcanii megapl... 117 2e-25
pir||S35669 alcohol dehydrogenase (EC 1.1.1.1) I - American alli... 117 2e-25
gb|AAK42630.1| Alcohol dehydrogenase (Zn containing) (adh-8) [Su... 116 3e-25
sp|P80222|ADH1_ALLMI ALCOHOL DEHYDROGENASE, MAJOR >gi|410008|gb|... 116 3e-25
gb|AAC60755.1| (S78778) class I alcohol dehydrogenase, ADH I {EC... 116 4e-25
sp|P49645|ADH1_APTAU ALCOHOL DEHYDROGENASE I >gi|2147185|pir||I5... 116 4e-25
gb|AAA25324.1| (L34345) xylitol dehydrogenase [Morganella morganii] 116 4e-25
sp|P41680|ADHA_PERMA ALCOHOL DEHYDROGENASE A CHAIN >gi|1363999|p... 116 5e-25
pir||T36399 probable alcohol dehydrogenase (zinc-binding) - Stre... 116 5e-25
gi|4501929 class I alcohol dehydrogenase 1 alpha subunit; alcoho... 115 6e-25
sp|O00097|ADH1_PICST ALCOHOL DEHYDROGENASE I (ADH 2) >gi|2143328... 115 6e-25
gb|AAD37848.1|AF112883_4 (AF112883) alcohol dehydrogenase [Pseud... 115 6e-25
gi|11435475 alcohol dehydrogenase 1 (class I), alpha polypeptide... 115 6e-25
dbj|BAB05730.1| (AP001514) benzyl alcohol dehydrogenase [Bacillu... 115 1e-24
sp|P19854|ADHX_HORSE ALCOHOL DEHYDROGENASE CLASS III CHAIN (GLUT... 114 1e-24
pir||S34613 5-exo-hydroxycamphor dehydrogenase (EC 1.1.1.-) - Ps... 114 1e-24
pdb|1HDZ|A Chain A, Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-1 ... 114 2e-24
gb|AAA53300.1| (U15924) alcohol dehydrogenase [Candida albicans] 114 2e-24
dbj|BAA35108.1| (AB020760) Phenylacetaldehyde reductase [Coryneb... 114 2e-24
gb|AAF73255.1|AF156708_1 (AF156708) alcohol dehydrogenase class ... 114 2e-24
gi|11499684 alcohol dehydrogenase, zinc-dependent [Archaeoglobus... 113 2e-24
gb|AAF73254.1|AF154331_1 (AF154331) alcohol dehydrogenase class ... 113 2e-24
sp|P12886|ADH1_PEA ALCOHOL DEHYDROGENASE 1 >gi|81891|pir||S00912... 113 3e-24
pir||B70853 probable adhD protein - Mycobacterium tuberculosis (... 113 3e-24
gb|AAC15839.1| (AF060871) hypothetical alcohol dehydrogenase [Rh... 113 3e-24
sp|P13603|ADH1_TRIRP ALCOHOL DEHYDROGENASE 1 >gi|65900|pir||DEJY... 113 4e-24
gb|AAA51884.1| (M24317) alcohol dehydrogenase beta subunit [Homo... 113 4e-24
pir||S53308 alcohol dehydrogenase (EC 1.1.1.1) 1CN - Phaseolus a... 113 4e-24
pir||S53307 alcohol dehydrogenase (EC 1.1.1.1) 1 - Phaseolus acu... 113 4e-24
sp|P39450|ADH3_PASPI PUTATIVE ALCOHOL DEHYDROGENASE CLASS III (G... 113 4e-24
sp|Q17334|ADH1_CAEEL ALCOHOL DEHYDROGENASE K12G11.3 >gi|7505839|... 113 4e-24
sp|P28469|ADH_MACMU ALCOHOL DEHYDROGENASE ALPHA CHAIN (ADH) >gi|... 112 5e-24
gb|AAB66676.1| (U73654) alcohol dehydrogenase ADH-F [Gallus gallus] 112 5e-24
sp|O19053|ADHX_RABIT ALCOHOL DEHYDROGENASE CLASS III CHAIN (GLUT... 112 5e-24
gb|AAF23556.1|AF110458_1 (AF110458) alcohol dehydrogenase [Barba... 112 5e-24
sp|P14139|ADH_PAPHA ALCOHOL DEHYDROGENASE (ADH) >gi|86651|pir||A... 112 7e-24
gb|AAF23528.1|AF110430_1 (AF110430) alcohol dehydrogenase [Carda... 112 7e-24
emb|CAB62734.1| (AL133423) putative dehydrogenase [Streptomyces ... 111 9e-24
gb|AAK42487.1| Alcohol dehydrogenase (Zn containing) (adh-6) [Su... 111 1e-23
sp|P25437|ADH3_ECOLI ALCOHOL DEHYDROGENASE CLASS III (GLUTATHION... 111 1e-23
gi|11435477 alcohol dehydrogenase 2 (class I), beta polypeptide ... 111 2e-23
pdb|1DEH|A Chain A, Crystallization Of Human Beta1 Alcohol Dehyd... 111 2e-23
pdb|1HDY|A Chain A, Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-2 ... 111 2e-23
sp|P80468|ADH2_STRCA ALCOHOL DEHYDROGENASE II 111 2e-23
gb|AAD37446.1| (AF153821) alcohol dehydrogenase beta2 subunit [H... 111 2e-23
sp|P73138|ADH3_SYNY3 PROBABLE ALCOHOL DEHYDROGENASE CLASS III (G... 110 2e-23
gb|AAF23539.1|AF110441_1 (AF110441) alcohol dehydrogenase [Halim... 110 2e-23
gb|AAF23549.1|AF110451_1 (AF110451) alcohol dehydrogenase [Arabi... 110 2e-23
sp|P09347|FDEH_PSEPU 5-EXO-ALCOHOL DEHYDROGENASE (FDEH) >gi|4737... 110 3e-23
gb|AAB48003.1| (L38290) alcohol dehydrogenase beta-3 subunit [Ho... 110 3e-23
sp|P44557|ADH3_HAEIN PUTATIVE ALCOHOL DEHYDROGENASE CLASS III (G... 110 3e-23
pdb|1HTB|A Chain A, Crystallization Of Human Beta3 Alcohol Dehyd... 110 3e-23
gb|AAD38247.1|AC006193_3 (AC006193) very similar to alcohol dehy... 110 3e-23
pir||B83373 probable alcohol dehydrogenase (Zn-dependent) PA2188... 110 3e-23
sp|P19631|ADH3_COTJA ALCOHOL DEHYDROGENASE ALPHA CHAIN (ADH3) >g... 109 4e-23
sp|P43067|ADH1_CANAL ALCOHOL DEHYDROGENASE 1 (40 KD ALLERGEN) (A... 109 4e-23
gb|AAG20655.1| (AE005134) alcohol dehydrogenase; Adh2 [Halobacte... 109 4e-23
sp|P80338|ADH1_STRCA ALCOHOL DEHYDROGENASE I >gi|1079371|pir||S4... 109 5e-23
pir||S57525 alcohol dehydrogenase (EC 1.1.1.1) C - Escherichia c... 109 5e-23
dbj|BAA22972.1| (D63453) alcohol dehydrogenase [Arabis gemmifera] 109 5e-23
pir||T18230 alcohol dehydrogenase (EC 1.1.1.1) II - yeast (Candi... 109 5e-23
sp|P45382|FADH_PARDE GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROG... 109 6e-23
emb|CAA33487.1| (X15447) alcohol dehydrogenase [Homo sapiens] 108 1e-22
gb|AAF18534.1|AC006551_20 (AC006551) Very similar to alcohol deh... 108 1e-22
sp|P00327|ADHE_HORSE ALCOHOL DEHYDROGENASE E CHAIN >gi|625197|pi... 108 1e-22
pdb|3BTO|A Chain A, Horse Liver Alcohol Dehydrogenase Complexed ... 108 1e-22
gb|AAB32020.1| Class I alcohol dehydrogenase, class I ADH {EC 1.... 108 1e-22
pdb|1AXE|A Chain A, Crystal Structure Of The Active-Site Mutant ... 108 1e-22
gb|AAF23532.1|AF110434_1 (AF110434) alcohol dehydrogenase [Brass... 108 1e-22
gb|AAF23533.1|AF110435_1 (AF110435) alcohol dehydrogenase [Capse... 108 1e-22
gb|AAF23546.1|AF110448_1 (AF110448) alcohol dehydrogenase [Arabi... 108 1e-22
gb|AAF23548.1|AF110450_1 (AF110450) alcohol dehydrogenase [Arabi... 108 1e-22
pir||DECHA1 alcohol dehydrogenase (EC 1.1.1.1) I - chicken 107 2e-22
sp|P23991|ADH1_CHICK ALCOHOL DEHYDROGENASE I 107 2e-22
pir||I60970 alcohol dehydrogenase (EC 1.1.1.1) I - pocket gopher... 107 2e-22
dbj|BAA19617.1| (D84242) alcohol dehydrogenase [Arabidopsis thal... 107 2e-22
dbj|BAA19620.1| (D84245) alcohol dehydrogenase [Arabidopsis thal... 107 2e-22
dbj|BAA22979.1| (D63461) alcohol dehydrogenase [Arabidopsis thal... 107 2e-22
gb|AAF23536.1|AF110438_1 (AF110438) alcohol dehydrogenase [Arabi... 107 2e-22
gb|AAF23545.1|AF110447_1 (AF110447) alcohol dehydrogenase [Arabi... 107 2e-22
emb|CAA27842.1| (X04299) gamma 2 subunit (aa 1-375) [Homo sapiens] 107 2e-22
pir||A26468 alcohol dehydrogenase (EC 1.1.1.1) I - rat >gi|20272... 107 2e-22
gi|9506375 Alcohol dehydrogenase 3 [Rattus norvegicus] >gi|11339... 107 2e-22
sp|P00328|ADHS_HORSE ALCOHOL DEHYDROGENASE S CHAIN >gi|625198|pi... 107 2e-22
sp|Q64413|ADHA_GEOBU ALCOHOL DEHYDROGENASE A CHAIN >gi|2147094|p... 107 2e-22
pdb|1EE2|B Chain B, The Structure Of Steroid-Active Alcohol Dehy... 107 2e-22
emb|CAA54911.1| (X77943) alcohol dehydrogenase [Arabidopsis thal... 107 2e-22
sp|P80360|ADHX_MYXGL ALCOHOL DEHYDROGENASE CLASS III (GLUTATHION... 107 2e-22
sp|P79896|ADHX_SPAAU ALCOHOL DEHYDROGENASE CLASS III (GLUTATHION... 107 2e-22
dbj|BAA19616.1| (D84241) alcohol dehydrogenase [Arabidopsis thal... 107 2e-22
pir||A48257 alcohol dehydrogenase (EC 1.1.1.1) I - pocket gopher... 107 2e-22
pdb|1AXG|A Chain A, Crystal Structure Of The Val203->ala Mutant ... 107 2e-22
pdb|1A71|A Chain A, Ternary Complex Of An Active Site Double Mut... 107 2e-22
gb|AAC98958.1| (AF044728) alcohol dehydrogenase [Geomys bursariu... 107 2e-22
sp|P12711|ADHX_RAT ALCOHOL DEHYDROGENASE CLASS III (ALCOHOL DEHY... 107 2e-22
gb|AAD09950.1| (L30113) alcohol dehydrogenase; ADH [Papio hamadr... 107 2e-22
pir||T33939 probable alcohol dehydrogenase (EC 1.1.1.1) [similar... 107 2e-22
gb|AAF23529.1|AF110431_1 (AF110431) alcohol dehydrogenase [Arabi... 107 2e-22
pdb|1EE2|A Chain A, The Structure Of Steroid-Active Alcohol Dehy... 107 2e-22
sp|P06525|ADH1_ARATH ALCOHOL DEHYDROGENASE >gi|65899|pir||DEMUAM... 106 3e-22
gi|4501933 class I alcohol dehydrogenase 3 gamma subunit; alcoho... 106 3e-22
gb|AAF23551.1|AF110453_1 (AF110453) alcohol dehydrogenase [Arabi... 106 3e-22
pir||I60974 alcohol dehydrogenase (EC 1.1.1.1) - pocket gopher (... 106 4e-22
dbj|BAA22975.1| (D63456) alcohol dehydrogenase [Arabis gemmifera] 106 4e-22
gb|AAF23537.1|AF110439_1 (AF110439) alcohol dehydrogenase [Arabi... 106 4e-22
pir||F81097 probable alcohol dehydrogenase (EC 1.1.1.1) class II... 106 4e-22
sp|Q64415|ADHA_GEOKN ALCOHOL DEHYDROGENASE A CHAIN >gi|2147095|p... 106 5e-22
gi|4501941 class IV alcohol dehydrogenase 7 mu or sigma subunit;... 106 5e-22
emb|CAA53960.1| (X76342) alternative ORF [Homo sapiens] 106 5e-22
sp|P72324|ADHI_RHOSH ALCOHOL DEHYDROGENASE CLASS III (GLUTATHION... 106 5e-22
pdb|1D1S|A Chain A, Wild-Type Human Sigma (Class Iv) Alcohol Deh... 106 5e-22
dbj|BAA22973.1| (D63454) alcohol dehydrogenase [Arabis gemmifera... 106 5e-22
gb|AAC98957.1| (AF044724) alcohol dehydrogenase [Geomys knoxjonesi] 106 5e-22
pdb|1D1T|A Chain A, Mutant Of Human Sigma Alcohol Dehydrogenase ... 106 5e-22
gb|AAF23540.1|AF110442_1 (AF110442) alcohol dehydrogenase [Arabi... 106 5e-22
gb|AAF23541.1|AF110443_1 (AF110443) alcohol dehydrogenase [Arabi... 106 5e-22
pdb|1QLH|A Chain A, Horse Liver Alcohol Dehydrogenase Complexed ... 106 5e-22
gb|AAK41061.1| Alcohol dehydrogenase (Zn containing) (adh-2) [Su... 105 7e-22
emb|CAB57539.1| (Y18930) alcohol dehydrogenase (Zn containing) [... 105 7e-22
gb|AAD46162.1|AF130307_1 (AF130307) glutathione-dependent formal... 105 7e-22
gi|4501931 class I alcohol dehydrogenase 2 beta subunit; aldehyd... 105 9e-22
dbj|BAA22974.1| (D63455) alcohol dehydrogenase [Arabis gemmifera] 105 9e-22
gb|AAC62469.1| (AF079058) alcohol dehydrogenase Adh-1 [Glycine max] 105 9e-22
sp|P47734|FADH_METMR GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROG... 104 1e-21
gi|6319621 alcohol dehydrogenase isoenzyme V; Adh5p [Saccharomyc... 104 1e-21
dbj|BAA19621.1| (D84246) alcohol dehydrogenase [Arabidopsis thal... 104 1e-21
gb|AAC79416.1| (AF037558) alcohol dehydrogenase 2 [Leavenworthia... 104 1e-21
gb|AAD51737.1|AF175271_1 (AF175271) alcohol dehydrogenase 1 [Yar... 104 1e-21
gb|AAG09209.1|AF175685_1 (AF175685) mannitol-1-phosphate dehydro... 104 1e-21
sp|P14675|ADH3_SOLTU ALCOHOL DEHYDROGENASE 3 >gi|65903|pir||DEPO... 104 2e-21
gb|AAF18533.1|AC006551_19 (AC006551) Very similar to alcohol deh... 104 2e-21
pir||S11853 alcohol dehydrogenase (EC 1.1.1.1) 1 - potato >gi|74... 104 2e-21
gb|AAF23535.1|AF110437_1 (AF110437) alcohol dehydrogenase [Arabi... 104 2e-21
dbj|BAA22977.1| (D63458) alcohol dehydrogenase [Arabis gemmifera] 103 3e-21
dbj|BAA22978.1| (D63459) alcohol dehydrogenase [Arabis gemmifera] 103 3e-21
sp|P14673|ADH1_SOLTU ALCOHOL DEHYDROGENASE 1 >gi|169467|gb|AAA33... 103 3e-21
gi|6680652 alcohol dehydrogenase 5 [Mus musculus] >gi|113409|sp|... 103 3e-21
sp|P28032|ADH2_LYCES ALCOHOL DEHYDROGENASE 2 >gi|1076578|pir||S5... 103 3e-21
sp|P54202|ADH2_EMENI ALCOHOL DEHYDROGENASE II (ADH II) >gi|21332... 103 3e-21
dbj|BAB05670.1| (AP001513) unknown conserved protein [Bacillus h... 102 5e-21
pir||A53142 alcohol dehydrogenase (EC 1.1.1.1) IV - rat >gi|5458... 102 6e-21
emb|CAA67297.1| (X98746) alcohol dehydrogenase [Rattus norvegicus] 102 6e-21
sp|P41682|ADH7_RAT ALCOHOL DEHYDROGENASE CLASS IV 102 8e-21
gb|AAK41537.1| Alcohol dehydrogenase (Zn containing) (adh-4) [Su... 101 1e-20
dbj|BAA22971.1| (D63452) alchohol dehydrogenase [Arabis gemmifera] 101 1e-20
gb|AAF23550.1|AF110452_1 (AF110452) alcohol dehydrogenase [Arabi... 101 1e-20
gb|AAF23544.1|AF110446_1 (AF110446) alcohol dehydrogenase [Arabi... 101 2e-20
gb|AAG01383.1|AF194175_1 (AF194175) alcohol dehydrogenase 3 [Vit... 101 2e-20
dbj|BAA24528.1| (AB010636) SADH [Candida parapsilosis] 100 2e-20
gb|AAC49540.1| (U48367) alcohol dehydrogenase [Pinus banksiana] ... 100 3e-20
pir||B72395 alcohol dehydrogenase, zinc-containing - Thermotoga ... 100 3e-20
gb|AAD51739.1|AF175273_1 (AF175273) alcohol dehydrogenase 3 [Yar... 99 5e-20
sp|P04707|ADH2_MAIZE ALCOHOL DEHYDROGENASE 2 >gi|82671|pir||A230... 99 9e-20
pir||T49118 alcohol dehydrogenase like protein - Arabidopsis tha... 98 2e-19
gb|AAC35913.1| (AF066054) formaldehyde dehydrogenase [Pichia pas... 97 3e-19
pir||S10621 alcohol dehydrogenase (EC 1.1.1.1) beta-2 - human (f... 97 4e-19
pir||T36504 probable quinone oxidoreductase - Streptomyces coeli... 94 2e-18
dbj|BAB10198.1| (AB023032) alcohol dehydrogenase [Arabidopsis th... 94 2e-18
gb|AAB38424.1| (L47166) alcohol dehydrogenase 7 [Homo sapiens] >... 93 5e-18
sp|O46650|ADHQ_RABIT ALCOHOL DEHYDROGENASE CLASS II ISOZYME 2 >g... 92 7e-18
gb|AAF34412.1|AF172282_1 (AF172282) alcohol dehydrogenase 2 [Ory... 92 7e-18
sp|P20306|ADH1_ORYSA ALCOHOL DEHYDROGENASE 1 >gi|100652|pir||JQ0... 89 8e-17
emb|CAA38433.1| (X54612) alcohol dehydrogenase [Gallus gallus] 89 8e-17
pir||C75441 probable NADPH quinone oxidoreductase - Deinococcus ... 89 1e-16
prf||1909341A alcohol dehydrogenase [Glycine max] 89 1e-16
sp|Q17335|ADHX_CAEEL ALCOHOL DEHYDROGENASE CLASS III (GLUTATHION... 89 1e-16
sp|P18332|ADH2_ORYSA ALCOHOL DEHYDROGENASE 2 >gi|65904|pir||DERZ... 88 2e-16
gb|AAF55731.1| (AE003728) CG4836 gene product [Drosophila melano... 85 9e-16
gb|AAB33481.2| (S75487) alcohol dehydrogenase ADH [Lycopersicon... 85 1e-15
gb|AAC04784.1| (AF036920) aryl-alcohol dehydrogenase homolog [Rh... 79 9e-14
gb|AAD19419.1| (AF102543) unknown [Zymomonas mobilis] 78 1e-13
pir||S57614 ARP protein - Arabidopsis thaliana >gi|886434|emb|CA... 78 2e-13
gb|AAG13062.1|AC011807_21 (AC011807) ARP protein [Arabidopsis th... 78 2e-13
gb|AAF25975.1|AC017118_12 (AC017118) F6N18.16 [Arabidopsis thali... 76 8e-13
pir||T40965 alcohol dehydrogenase (EC 1.1.1.1) class III [simila... 75 1e-12
pir||T35960 crotonyl-CoA reductase - Streptomyces coelicolor >gi... 72 9e-12
>pir||G75049 L-threonine 3-dehydrogenase (EC 1.1.1.103) PAB2382 - Pyrococcus
abyssi (strain Orsay) >gi|5458805|emb|CAB50292.1|
(AJ248287) THREONINE 3-DEHYDROGENASE (EC 1.1.1.103).
[Pyrococcus abyssi]
Length = 348
Score = 712 bits (1818), Expect = 0.0
Identities = 348/348 (100%), Positives = 348/348 (100%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK
Sbjct: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD 120
PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD
Sbjct: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD 120
Query: 121 TDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLG 180
TDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLG
Sbjct: 121 TDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLG 180
Query: 181 LLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF 240
LLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF
Sbjct: 181 LLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF 240
Query: 241 LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETW 300
LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETW
Sbjct: 241 LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETW 300
Query: 301 YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK 348
YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK
Sbjct: 301 YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK 348
>pir||H71110 probable dehydrogenase - Pyrococcus horikoshii
>gi|3257063|dbj|BAA29746.1| (AP000003) 348aa long
hypothetical dehydrogenase [Pyrococcus horikoshii]
Length = 348
Score = 707 bits (1806), Expect = 0.0
Identities = 342/348 (98%), Positives = 347/348 (99%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
MSEKMVAIMKTKP YGAELVEVDVPKPGPGEVLIKV+ATSICGTDLHIYEWNEWAQSRIK
Sbjct: 1 MSEKMVAIMKTKPGYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIK 60
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD 120
PPQIMGHEVAGEVVE+GPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD
Sbjct: 61 PPQIMGHEVAGEVVEIGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD 120
Query: 121 TDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLG 180
TDGVFAEYAVVPAQN+WKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLG
Sbjct: 121 TDGVFAEYAVVPAQNIWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLG 180
Query: 181 LLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF 240
LLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF
Sbjct: 181 LLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF 240
Query: 241 LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETW 300
LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKV+IDFNNLIIFKALT+YGITGRHLWETW
Sbjct: 241 LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVTIDFNNLIIFKALTIYGITGRHLWETW 300
Query: 301 YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK 348
YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK
Sbjct: 301 YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK 348
>sp|O31776|TDH_BACSU THREONINE 3-DEHYDROGENASE >gi|7427644|pir||C69721 L-threonine
3-dehydrogenase (EC 1.1.1.103) - Bacillus subtilis
>gi|2634071|emb|CAB13572.1| (Z99112) threonine
3-dehydrogenase [Bacillus subtilis]
Length = 347
Score = 349 bits (886), Expect = 3e-95
Identities = 169/345 (48%), Positives = 231/345 (65%), Gaps = 1/345 (0%)
Query: 2 SEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP 61
S KM A+MK A+GA L EV +P+ EVLIKV A SICGTD+HIY W++WA+ RIK
Sbjct: 3 SGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICGTDVHIYNWDQWARQRIKT 62
Query: 62 PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT 121
P + GHE +G V VG V ++VG+YVS ETHIVCG+C C G+ HVC NT I GVDT
Sbjct: 63 PYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECVPCLTGKSHVCTNTAIIGVDT 122
Query: 122 DGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGL 181
G FAEY VPA N+W+NP + P A++QEPLGNAV TVL +G + + G GP+GL
Sbjct: 123 AGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVHTVLESQPAGGTTAVIGCGPIGL 182
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
+ +AVAKA+GA VI + +++R LAK++GA ++ +ED +K V +T G G D+
Sbjct: 183 MAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTVSIEKEDPLKIVSALTSGEGADLVC 242
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY 301
E SG P A+ QGL GR +L L V+ID N ++FK LT+ GITGR ++ TW
Sbjct: 243 EMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTIDLTNKVVFKGLTIQGITGRKMFSTWR 302
Query: 302 TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFM 346
VS+L+ S ++L P+ITH++ +++E+ FELMR+G+ GKV+ +
Sbjct: 303 QVSQLISSNMIDLAPVITHQFP-LEEFEKGFELMRSGQCGKVILI 346
>pir||B82405 threonine 3-dehydrogenase VCA0885 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9658319|gb|AAF96783.1|
(AE004416) threonine 3-dehydrogenase [Vibrio cholerae]
Length = 343
Score = 310 bits (787), Expect = 1e-83
Identities = 151/341 (44%), Positives = 228/341 (66%), Gaps = 3/341 (0%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K+ A+ K KP G + EVD+P+ G ++LIK+ T+ICGTD+HIY W+EW+Q I P
Sbjct: 2 KIKALSKLKPEQGIWMNEVDMPELGHNDLLIKIKKTAICGTDVHIYNWDEWSQKTIPVPM 61
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDG 123
++GHE GEVV +G V G ++GD VS E HI CG C CR G+ H+C+NT GV+ G
Sbjct: 62 VVGHEYVGEVVGIGQEVRGFQIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRTG 121
Query: 124 VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLG 183
F+EY V+PA N +K P I + A++ +P GNAV T L+ + G+ VLITGAGP+G++
Sbjct: 122 CFSEYLVIPAFNAFKIPDGISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMA 181
Query: 184 IAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEF 243
AVAK GA V++++ +++R +LA+K+G +N E+++ + ++ G DV LE
Sbjct: 182 AAVAKHVGARHVVITDVNEYRLDLARKMGVTRAVNVAEQNLEDVMKELGMTEGFDVGLEM 241
Query: 244 SGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTV 303
SG P A L+ + GR++LLG+ P ++ID+N +IFK L + GI GR ++ETWY +
Sbjct: 242 SGVPSAFSAMLKTMNHGGRIALLGIPPSSMAIDWNQ-VIFKGLVIKGIYGREMFETWYKM 300
Query: 304 SRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+ L+QSG L++ PIITH +K D +++ F++MR+G +GKV+
Sbjct: 301 ASLIQSG-LDISPIITHHFK-VDDFQKGFDIMRSGASGKVI 339
>sp|Q52998|TDH_RHIME THREONINE 3-DEHYDROGENASE
Length = 344
Score = 303 bits (767), Expect = 2e-81
Identities = 153/344 (44%), Positives = 220/344 (63%), Gaps = 3/344 (0%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
M+ M A++KTKP G + V VP+ GP +VLI+V ++ICGTD+HI+ W++WA+ I
Sbjct: 1 MTNMMKALVKTKPEVGLWMERVPVPEIGPNDVLIRVRKSAICGTDVHIWNWDQWAEKTIP 60
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD 120
P ++GHE GEVVEVGP V VG+ VS E HIVCGKC CR G+ H+C+NT GV+
Sbjct: 61 VPMVVGHEFMGEVVEVGPAVSKHHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVN 120
Query: 121 TDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLG 180
G FAE+ +P NV P +P E A + +P GNAV T L+ + G+ VL+TGAGP+G
Sbjct: 121 RPGSFAEFVCLPEYNVVSIPDDVPDEIAAIFDPFGNAVHTALSFDLVGEDVLVTGAGPIG 180
Query: 181 LLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF 240
++G VAK GA V++++ + R +LA+K+G D+V++ +E + + I G DV
Sbjct: 181 IMGAMVAKRCGARKVVITDINPVRLDLARKLGIDHVVDASKEKLADVMRVIGMTEGFDVG 240
Query: 241 LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETW 300
LE SGA A + + G++++LG+ P ID+N +IFK L + GI GR ++ETW
Sbjct: 241 LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNK-VIFKMLNLKGIYGREMFETW 299
Query: 301 YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
Y + +Q G L+L PIITH+ G D + + FE MR+G +GKVV
Sbjct: 300 YKMIAFVQGG-LDLSPIITHRI-GIDDFRDGFEAMRSGNSGKVV 341
>sp|P07913|TDH_ECOLI THREONINE 3-DEHYDROGENASE >gi|65905|pir||DEECTH L-threonine
3-dehydrogenase (EC 1.1.1.103) - Escherichia coli
>gi|41864|emb|CAA29884.1| (X06690) tdh gene [Escherichia
coli] >gi|466754|gb|AAB18593.1| (U00039) threonine
dehydrogenase [Escherichia coli]
>gi|1790045|gb|AAC76640.1| (AE000439) threonine
dehydrogenase [Escherichia coli K12]
Length = 341
Score = 302 bits (765), Expect = 4e-81
Identities = 149/340 (43%), Positives = 225/340 (65%), Gaps = 3/340 (0%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M A+ K K G + +V VP+ G ++LIK+ T+ICGTD+HIY W+EW+Q I P +
Sbjct: 1 MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV 60
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
+GHE GEVV +G V+G ++GD VS E HI CG C CR G+ H+C+NT GV+ G
Sbjct: 61 VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGC 120
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGI 184
FAEY V+PA N +K P +I + A + +P GNAV T L+ + G+ VL++GAGP+G++
Sbjct: 121 FAEYLVIPAFNAFKIPDNISDDLAAIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAA 180
Query: 185 AVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFS 244
AVAK GA V++++ +++R ELA+K+G +N +E++ + ++ G DV LE S
Sbjct: 181 AVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMS 240
Query: 245 GAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVS 304
GAP A L + GR+++LG+ P +SID+ +IFK L + GI GR ++ETWY ++
Sbjct: 241 GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTK-VIFKGLFIKGIYGREMFETWYKMA 299
Query: 305 RLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
L+QSG L+L PIITH++ D +++ F+ MR+G++GKV+
Sbjct: 300 ALIQSG-LDLSPIITHRF-SIDDFQKGFDAMRSGQSGKVI 337
>pir||A75371 threonine 3-dehydrogenase - Deinococcus radiodurans (strain R1)
>gi|6459424|gb|AAF11215.1|AE002008_10 (AE002008)
threonine 3-dehydrogenase [Deinococcus radiodurans]
Length = 370
Score = 301 bits (763), Expect = 7e-81
Identities = 149/344 (43%), Positives = 226/344 (65%), Gaps = 8/344 (2%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
+M A+ K +P G ++E +VP PGP ++LI++ SICGTD+HIY+W++WA + P
Sbjct: 22 RMRALSKQQPGEGIWMIETEVPTPGPNDLLIRIRKGSICGTDVHIYKWDDWASQTVPVPM 81
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDG 123
++GHE G V +G V G E+GD VS E H+ CG C CR G+ H+C+NT+ GV+ G
Sbjct: 82 VVGHEYVGVVAGMGSEVRGFEIGDRVSGEGHVTCGHCRNCRAGRRHLCRNTQGVGVNRPG 141
Query: 124 VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLG 183
FAEY V+PA N +K P IP + A + +P GNAV T L+ + G+ VLITGAGP+G +
Sbjct: 142 SFAEYLVLPAFNAFKLPDDIPDDVAAIFDPFGNAVHTALSFDLVGEDVLITGAGPIGCMA 201
Query: 184 IAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED---VVKEVMDITDGNGVDVF 240
AVA+ GA V++++ +D+R +LA+++G +N ED V + +D+ + G DV
Sbjct: 202 AAVARHVGARNVVITDVNDYRLDLARQMGVTRAVNVAREDLWTVATQELDMHE--GFDVG 259
Query: 241 LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETW 300
+E SG+ A Q + + G+V+LLG+ G+V ID+ N +IFK LT+ GI GR ++ETW
Sbjct: 260 MEMSGSGPAFAQMVSVMNNGGKVALLGIPSGEVQIDW-NAVIFKMLTIKGIYGREMFETW 318
Query: 301 YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
Y ++ L+QSG L+L P+ITH Y G +++ F+ M +G++GKV+
Sbjct: 319 YKMAALIQSG-LDLTPVITHHY-GIGDFQQGFDAMLSGQSGKVI 360
>sp|O34268|TDH_XANCP THREONINE 3-DEHYDROGENASE >gi|7427643|pir||JC5524 L-threonine
3-dehydrogenase (EC 1.1.1.103) - Xanthomonas campestris
pv. campestris >gi|2228763|gb|AAC45449.1| (U96384)
threonine dehydrogenase [Xanthomonas campestris pv.
campestris]
Length = 340
Score = 295 bits (747), Expect = 6e-79
Identities = 154/340 (45%), Positives = 212/340 (62%), Gaps = 4/340 (1%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M A++K + + G L +V VP PGP EVLIK+ T+ICGTDLHIY W+EW+Q I P
Sbjct: 1 MKALVKREASKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTITPGLT 60
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
+GHE G V E+G V G +VG VS E HIVCG C CR G+ H+C NT GV+ +G
Sbjct: 61 IGHEFVGRVAELGSAVTGYQVGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGA 120
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGI 184
FAEY V+PA N+W P IP E A +P GNA L + G+ VLITGAGP+G++
Sbjct: 121 FAEYMVMPASNLWPIPDQIPSELAAFFDPYGNAAHCALEFDVIGEDVLITGAGPIGIIAA 180
Query: 185 AVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFS 244
+ K GA V+V++ +DFR +LA +GA V+N + +K+VM G DV LE S
Sbjct: 181 GICKHIGARNVVVTDVNDFRLKLAADLGATRVVN-VSKTSLKDVMADLHMEGFDVGLEMS 239
Query: 245 GAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVS 304
G P+A L + G++++LG+ P D++ IIFK LTV GI GR ++ETWY ++
Sbjct: 240 GNPRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDK-IIFKGLTVQGIYGRKMYETWYKMT 298
Query: 305 RLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+L+ SG L ++TH+ D++++ F+LM GK GKVV
Sbjct: 299 QLVLSG-FPLQKVLTHQL-SIDEFQKGFDLMEEGKAGKVV 336
>emb|CAB71246.1| (AL138598) threonine 3-dehydrogenase. [Streptomyces coelicolor
A3(2)]
Length = 342
Score = 279 bits (707), Expect = 3e-74
Identities = 147/340 (43%), Positives = 211/340 (61%), Gaps = 3/340 (0%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M A++K G L +V P G G+VLIKV+ T ICGTDLHI W+ WAQ I+ P +
Sbjct: 1 MKALVKENAEPGLWLADVPEPTIGSGDVLIKVLRTGICGTDLHIRAWDGWAQQAIRTPLV 60
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
+GHE GEVV+ G V I+ GD VS E H+VCGKC C G+ H+C+ T GV DG
Sbjct: 61 VGHEFVGEVVDTGRDVTDIKAGDRVSGEGHLVCGKCRNCLAGRRHLCRATVGLGVGRDGA 120
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGI 184
FAEY +PA NVW + + + A + +P GNAV T L+ P+ G+ VLITGAGP+GL+
Sbjct: 121 FAEYVALPASNVWVHRVPVDLDVAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGLMAA 180
Query: 185 AVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFS 244
AVA+ +GA V++++ S+ R ELA+KVGA +N + + ++ G D+ LE S
Sbjct: 181 AVARHAGARNVVITDVSEERLELARKVGATLALNVSDATIADGQRELGLREGFDIGLEMS 240
Query: 245 GAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVS 304
G P+A+ + +T GR+++LGL + +D+ ++ +TV GI GR ++ETWY +S
Sbjct: 241 GRPEAMRDMIANMTHGGRIAMLGLPAEEFPVDWAR-VVTSMITVKGIYGREMFETWYAMS 299
Query: 305 RLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
LL+ G L+L P+IT +Y D +E AF +G+ GKV+
Sbjct: 300 VLLEGG-LDLAPVITGRYSHRD-FEAAFADAASGRGGKVI 337
>gb|AAB70823.1| (AF019635) benzyl alcohol dehydrogenase [Pseudomonas putida]
Length = 348
Score = 263 bits (665), Expect = 2e-69
Identities = 148/344 (43%), Positives = 210/344 (61%), Gaps = 6/344 (1%)
Query: 5 MVAIMKTKPAYGAELVE-VDVPKPGPG-EVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
M+AI KTK G V+ V PK +VL+KV A ICGTDL IY+W E+A+ R+K P
Sbjct: 1 MLAIRKTKAGPGGLSVDDVAAPKEAHSTDVLVKVEAAGICGTDLLIYKWGEFAK-RMKLP 59
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD 122
I+GHEV+G + +VG V+G+ G VS+E+H+ CG CY CRRG HVC NT+ GVD D
Sbjct: 60 TILGHEVSGVIEQVGSDVKGLRPGMRVSLESHLPCGTCYTCRRGWAHVCPNTRYPGVDFD 119
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGP-ISGKSVLITGAGPLGL 181
G FA + VVP W P IPP A + EP G AV L G +SG +VL++G GP+GL
Sbjct: 120 GGFASFVVVPESVCWPVPCGIPPLQAAMMEPFGLAVHASLEGSGVSGLNVLVSGCGPIGL 179
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
+ IA AKA GA VI ++ R A K+GAD IN EE V K V + GVDV +
Sbjct: 180 MNIAAAKALGASKVIATDIHPLRLTAAAKMGADECINATEESVYKTVRSLLGERGVDVAI 239
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY 301
++SG AL++ +Q++T G + L+G+ + ++ +FK L V G+ GR L+ETW
Sbjct: 240 DYSGQAAALKELIQSITHGGELRLMGVPSHDILLNLEEW-LFKGLIVRGLHGRRLFETWE 298
Query: 302 TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
+ LL +G+++L +++H+ E+AFE+ G++ K++F
Sbjct: 299 RSTSLLVTGRVDLSSLVSHRLP-LSAAEDAFEMALNGQSLKILF 341
>gb|AAC44788.1| (U20269) XylW hypothetical protein [Pseudomonas putida]
Length = 348
Score = 263 bits (665), Expect = 2e-69
Identities = 148/344 (43%), Positives = 210/344 (61%), Gaps = 6/344 (1%)
Query: 5 MVAIMKTKPAYGAELVE-VDVPKPGPG-EVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
M+AI KTK G V+ V PK +VL+KV A ICGTDL IY+W E+A+ R+K P
Sbjct: 1 MLAIRKTKAGPGGLSVDDVAAPKEAHSTDVLVKVEAAGICGTDLLIYKWGEFAK-RMKLP 59
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD 122
I+GHEV+G + +VG V+G+ G VS+E+H+ CG CY CRRG HVC T+ GVD D
Sbjct: 60 TILGHEVSGVIEQVGSDVKGLRPGMRVSLESHLPCGTCYTCRRGWAHVCPKTRYPGVDFD 119
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGP-ISGKSVLITGAGPLGL 181
G FA + VVP W P IPP AT+ EP G AV L G +SG +VL++G GP+GL
Sbjct: 120 GGFASFVVVPESVCWPVPCGIPPLQATMMEPFGLAVHASLEGSGVSGLNVLVSGCGPIGL 179
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
+ IA AKA GA VI ++ R A K+GAD IN EE V K V + GVDV +
Sbjct: 180 MNIAAAKALGASKVIATDIHPLRLTAAAKMGADECINATEESVYKTVRSLLGERGVDVAI 239
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY 301
++SG AL++ +Q++T G + L+G+ + ++ +FK L V G+ GR L+ETW
Sbjct: 240 DYSGQAAALKELIQSITHGGELRLMGVPSHDILLNLEEW-LFKGLIVRGLHGRRLYETWE 298
Query: 302 TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
+ LL +G+++L +++H+ E+AFE+ G++ K++F
Sbjct: 299 RSTSLLVTGRVDLSSLVSHRLP-LSAAEDAFEMALNGQSLKILF 341
>gb|AAA84986.1| (U41301) TmbW [Pseudomonas putida]
Length = 348
Score = 263 bits (665), Expect = 2e-69
Identities = 148/344 (43%), Positives = 210/344 (61%), Gaps = 6/344 (1%)
Query: 5 MVAIMKTKPAYGAELVE-VDVPKPGPG-EVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
M+AI KTK G V+ V PK +VL+KV A ICGTDL IY+W E+A+ R+K P
Sbjct: 1 MLAIRKTKAGPGGLSVDDVAAPKEAHSTDVLVKVEAAGICGTDLLIYKWGEFAK-RMKLP 59
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD 122
I+GHEV+G + +VG V+G+ G VS+E+H+ CG CY CRRG HVC NT+ GVD D
Sbjct: 60 TILGHEVSGVIEQVGSDVKGLRPGMRVSLESHLPCGTCYTCRRGWAHVCPNTRYPGVDFD 119
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGP-ISGKSVLITGAGPLGL 181
G FA + VVP W P IPP A + EP G AV L G +SG +VL++G GP+GL
Sbjct: 120 GGFASFVVVPESVCWPVPCGIPPLQAAMMEPFGLAVHASLEGSGVSGLNVLVSGCGPIGL 179
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
+ IA AKA GA VI ++ R A K+GAD IN EE V K V + GVDV +
Sbjct: 180 MNIAAAKALGASKVIATDIHPLRLTAAAKMGADECINATEESVYKTVRSLLGERGVDVAI 239
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY 301
++SG AL++ +Q++T G + L+G+ + ++ +FK L V G+ GR L+ETW
Sbjct: 240 DYSGQAAALKELIQSITHGGELRLMGVPSHDILLNLEEW-LFKGLIVRGLHGRRLFETWE 298
Query: 302 TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
+ LL +G+++L +++H+ E+AFE+ G++ K++F
Sbjct: 299 RSTSLLVTGRVDLSSLVSHRLP-LSAAEDAFEMALNGESLKILF 341
>gb|AAC38358.1| (AF043544) putative alcohol dehydrogenase NtnW [Pseudomonas sp.
TW3]
Length = 348
Score = 261 bits (660), Expect = 9e-69
Identities = 147/344 (42%), Positives = 209/344 (60%), Gaps = 6/344 (1%)
Query: 5 MVAIMKTKPAYGAELVE-VDVPKPGPG-EVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
M+AI KTK G V+ V PK +VL+KV A ICGTDL IY+W E+A+ R+K P
Sbjct: 1 MLAIRKTKAGPGGLSVDDVAAPKEAHSTDVLVKVEAAGICGTDLLIYKWGEFAK-RMKLP 59
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD 122
I+GHEV+G + +VG V+G+ G VS+E+H+ CG CY CRRG HVC T+ GVD D
Sbjct: 60 TILGHEVSGVIEQVGSDVKGLRPGMRVSLESHLPCGTCYTCRRGWAHVCPKTRYPGVDFD 119
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGP-ISGKSVLITGAGPLGL 181
G FA + VVP W P IPP A + EP G AV L G +SG +VL++G GP+GL
Sbjct: 120 GGFASFVVVPESVCWPVPCGIPPLQAAMMEPFGLAVHASLEGSGVSGLNVLVSGCGPIGL 179
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
+ IA AKA GA VI ++ R A K+GAD IN EE V K V + GVDV +
Sbjct: 180 MNIAAAKALGASKVIATDIHPLRLTAAAKMGADECINAAEESVYKTVRSLLGERGVDVAI 239
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY 301
++SG AL++ +Q++T G + L+G+ + ++ +FK L V G+ GR L+ETW
Sbjct: 240 DYSGQAAALKELIQSITHGGELRLMGVPSHDILLNLEEW-LFKGLIVRGLHGRRLYETWE 298
Query: 302 TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
+ LL +G+++L +++H+ E+AFE+ G++ K++F
Sbjct: 299 RSTSLLVTGRVDLSSLVSHRLP-LSAAEDAFEMALNGQSLKILF 341
>dbj|BAA09660.1| (D63341) benzyl alcohol dehydrogenase II [Pseudomonas putida]
Length = 348
Score = 258 bits (652), Expect = 8e-68
Identities = 146/344 (42%), Positives = 207/344 (59%), Gaps = 6/344 (1%)
Query: 5 MVAIMKTKPAYGAELVE-VDVPKPGPG-EVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
M+AI KTK G V+ V PK +VL+KV A ICGTDL IY+W E+A+ R+K P
Sbjct: 1 MLAIRKTKAGPGGLSVDDVAAPKEAHSTDVLVKVEAAGICGTDLLIYKWGEFAK-RMKLP 59
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD 122
I+GHEV+G + +VG V+G+ G VS+E+H+ CG CY CRRG HVC T+ GVD D
Sbjct: 60 TILGHEVSGVIEQVGSDVKGLRPGMRVSLESHLPCGTCYTCRRGWAHVCPKTRYPGVDFD 119
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGP-ISGKSVLITGAGPLGL 181
G FA + VVP W P IPP A + EP G AV L G +SG +VL++G GP+GL
Sbjct: 120 GGFASFVVVPESVCWPVPCGIPPLQAAMMEPFGLAVHASLEGSGVSGLNVLVSGCGPIGL 179
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
+ IA AKA GA VI + R A K+GAD IN EE V K V + GVDV +
Sbjct: 180 MNIAAAKALGASKVIAPDIHPLRLTAAAKMGADECINATEESVYKTVRSLLGERGVDVAI 239
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY 301
++SG AL++ +Q++T G + L+G+ + ++ +FK L V G+ GR L+E W
Sbjct: 240 DYSGQAAALKELIQSITHGGELRLMGVPSHDILLNLEEW-LFKGLIVRGLHGRRLYERWE 298
Query: 302 TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
+ LL +G+++L +++H+ E+AFE+ G++ K++F
Sbjct: 299 RSTSLLVTGRVDLSSLVSHRLP-LSAAEDAFEMALNGQSLKILF 341
>dbj|BAA75341.1| (AB011837) sorbitol dehydrogenase [Bacillus halodurans]
>gi|10172801|dbj|BAB03908.1| (AP001507) sorbitol
dehydrogenase [Bacillus halodurans]
Length = 343
Score = 197 bits (496), Expect = 1e-49
Identities = 123/345 (35%), Positives = 189/345 (54%), Gaps = 12/345 (3%)
Query: 5 MVAIMKTKPAYGAELV-EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
M A++KT+ G V E P PG +V IKV T +CG+D+H YE + P
Sbjct: 1 MKALVKTQHGTGHFAVQEKPEPTPGKHQVKIKVKYTGVCGSDIHTYE----GHYPVAAPV 56
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVET-HIVCGKCYACRRGQYHVCQNTKIFGVDTD 122
+GHE +GE+VE+G GV G VGD V+ ET + +CGKC C G Y++C + K G D
Sbjct: 57 TLGHEFSGEIVELGEGVTGFNVGDRVTSETTYSICGKCSYCTSGDYNLCSHRKGLGNQQD 116
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGL 181
G FA+Y + +++ P + A + EPL + I+ G V++TG GP+GL
Sbjct: 117 GSFAKYVIARQESLHHLPAGVDDRSAAMTEPLACTHHAIAKTSINKGDLVVVTGPGPIGL 176
Query: 182 LGIAVAKASGAYPVIVSEPSD-FRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF 240
L VAK+ G +I +D R + AK+VG DY I+ E D+ + V ++TDG G DV
Sbjct: 177 LAAQVAKSHGGTVIITGLSNDQVRLKKAKEVGIDYAIDTQEVDIKELVSELTDGYGADVV 236
Query: 241 LEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFN-NLIIFKALTVYGITGRHLWET 299
LE SGA A +QG+ + G+ + +GL+ + I FN II K ++V G + +
Sbjct: 237 LECSGAVPAAKQGIDLLRKKGQYAQVGLF-AQPEIQFNFEKIIQKEISVVGSRSQKPAD- 294
Query: 300 WYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
W LL K+N ++TH+Y ++++A+ +++G+ KV+
Sbjct: 295 WEPALSLLNEKKVNAKTLVTHEYT-ISEWDKAYHAIKSGEAIKVL 338
>sp|Q06004|DHSO_BACSU SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE) (GLUCITOL
DEHYDROGENASE) >gi|322198|pir||A45052 L-iditol
2-dehydrogenase (EC 1.1.1.14) - Bacillus subtilis
>gi|304153|gb|AAA22508.1| (M96947) sorbitol
dehydrogenase [Bacillus subtilis]
>gi|2632928|emb|CAB12434.1| (Z99107) sorbitol
dehydrogenase [Bacillus subtilis]
Length = 353
Score = 186 bits (468), Expect = 3e-46
Identities = 111/313 (35%), Positives = 171/313 (54%), Gaps = 7/313 (2%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
VP EVLIKV+A ICG+DLH Y ++ P I+GHE AGE+ VG V+
Sbjct: 27 VPDINHDEVLIKVMAVGICGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQF 86
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVWKNPKS 142
+VGD V+VE + CG+C AC+ G+Y++C + + DG F +Y + V+ P S
Sbjct: 87 KVGDRVAVEPGVTCGRCEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDS 146
Query: 143 IPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E A L EP + + G ++ I G GP+GL+ +A AKA GA +IV++
Sbjct: 147 LSYEEAALIEPFSVGIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLE 206
Query: 202 DFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAG 261
R E AKK+GA ++IN E+D ++E+ IT+ GVDV E +G P AL+ L +V G
Sbjct: 207 PLRLEAAKKMGATHIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGG 266
Query: 262 RVSLLGLYPGKVSIDFN-NLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITH 320
+++++GL P + I N I + +YGI T+ L SG ++ ++T
Sbjct: 267 KLAIVGL-PSQNEIPLNVPFIADNEIDIYGIF--RYANTYPKGIEFLASGIVDTKHLVTD 323
Query: 321 KYKGFDKYEEAFE 333
+Y ++ ++A E
Sbjct: 324 QY-SLEQTQDAME 335
>pir||F69852 L-iditol 2-dehydrogenase (EC 1.1.1.14) homolog yjmD - Bacillus
subtilis >gi|2612905|gb|AAC46329.1| (AF015825)
zinc-containing alcohol dehydrogenase [Bacillus
subtilis] >gi|2633587|emb|CAB13090.1| (Z99110) similar
to sorbitol dehydrogenase [Bacillus subtilis]
Length = 339
Score = 176 bits (443), Expect = 2e-43
Identities = 114/333 (34%), Positives = 179/333 (53%), Gaps = 16/333 (4%)
Query: 9 MKTKPAYGAELVEVDVPKP---GPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIM 65
++ + AY +LV +V KP EVL+KV ICG+D+HIY + P+++
Sbjct: 4 VQVRKAY--DLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHIYHGTNPLATL---PRVI 58
Query: 66 GHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVF 125
GHEV G+V VG V+ ++ GD+V +E CG CYACR+G+ +VC +FGV DG
Sbjct: 59 GHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPNVCAKLSVFGVHEDGGM 118
Query: 126 AEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPI-SGKSVLITGAGPLGLLGI 184
EY V+P + + K +P E A + EP V G + G +VLI GAGP+G+ +
Sbjct: 119 REYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVEKGDTVLIQGAGPIGICVL 178
Query: 185 AVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFS 244
+AK +GA V++++ ++ R AK+ GAD V+N E V + V++ T G +V ++
Sbjct: 179 KMAKLAGA-AVMMTDLNNERLAFAKENGADAVVNVQAEHVAERVLEWTGNEGANVVIDAV 237
Query: 245 GAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY-TV 303
P+ ++AV+PAG V +LG + + + L I K ITG L + V
Sbjct: 238 CLPETFALSIEAVSPAGHVVVLGF--DERAAQISQLPITKKEVT--ITGSRLQTNQFPKV 293
Query: 304 SRLLQSGKLNLDPIITHKYKGFDKYEEAFELMR 336
LL G+L + ++TH + D AF+ ++
Sbjct: 294 VELLNGGRLMHNGLVTHTF-SVDDVHHAFQFIK 325
>dbj|BAA95897.1| (AB042810) NAD-dependent sorbitol dehydrogenase [Eriobotrya
japonica]
Length = 371
Score = 176 bits (443), Expect = 2e-43
Identities = 112/333 (33%), Positives = 180/333 (53%), Gaps = 16/333 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P GP +V +++ A ICG+D+H ++ +K P ++GHE AG + EVG VE +
Sbjct: 46 LPNLGPHDVRVRLKAVGICGSDVHHFKNMRCVDFIVKEPMVIGHECAGIIEEVGSEVEDL 105
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFG-VDTDGVFAEYAVVPAQNVWKNPKS 142
GD V++E I C +C C++G+Y++C+ K FG +G A V P +K P +
Sbjct: 106 VPGDRVALEPGISCKRCNLCKQGRYNLCRKMKFFGSPPNNGCLANQVVHPGDLCFKLPDN 165
Query: 143 IPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E + EPL + A +VL+ GAGP+GL+ + A+A GA +++++ +
Sbjct: 166 VSLEEGAMCEPLSVGIHACRRANVCQETNVLVVGAGPIGLVTLLAARAFGAPRIVIADVN 225
Query: 202 DFRRELAKKVGADYVINPFE--EDVVKEVMDITD--GNGVDVFLEFSGAPKALEQGLQAV 257
D R +AK +GAD V+ ED+ +EV I NGVDV + +G K + L A
Sbjct: 226 DERLSIAKSLGADEVVKVSTNIEDLAEEVATIQKVLENGVDVSFDCAGFDKTITTALSAT 285
Query: 258 TPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPI 317
P G+V L+G+ ++++ + + + V GI TW L+SGK+++ P+
Sbjct: 286 RPGGKVCLVGMGQREMTLP----LATREIDVIGIF--RYQNTWPLCLEFLRSGKIDVKPL 339
Query: 318 ITHKYKGFD--KYEEAFEL-MRAGKTGKVVFML 347
ITH++ GF + EEAFE R G KV+F L
Sbjct: 340 ITHRF-GFSQKEVEEAFETSARGGNAIKVMFNL 371
>dbj|BAA36481.2| (AB016256) NAD-dependent sorbitol dehydrogenase [Malus x domestica]
Length = 371
Score = 176 bits (441), Expect = 4e-43
Identities = 113/333 (33%), Positives = 180/333 (53%), Gaps = 16/333 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P GP +V +++ A ICG+D+H ++ +K P ++GHE AG + EVG VE +
Sbjct: 46 LPNLGPHDVRVRLRAVGICGSDVHHFKNMRCVDFIVKEPMVIGHECAGIIEEVGSEVEHL 105
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFG-VDTDGVFAEYAVVPAQNVWKNPKS 142
GD V++E I C +C C++G+Y++C+ K FG +G A V P +K P +
Sbjct: 106 VPGDRVALEPGISCKRCNLCKQGRYNLCRKMKFFGSPPNNGCLANQVVHPGDLCFKLPDN 165
Query: 143 IPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E + EPL + A +VL+ GAGP+GL+ + A+A GA +++++ +
Sbjct: 166 VSLEEGAMCEPLSVGIHACRRANVCQETNVLVVGAGPIGLVTLLAARAFGAPRIVIADVN 225
Query: 202 DFRRELAKKVGADYVINPFE--EDVVKEVMDITD--GNGVDVFLEFSGAPKALEQGLQAV 257
D R +AK +GAD V+ EDV +EV I NGVDV + +G K + L A
Sbjct: 226 DERLLIAKSLGADAVVKVSTNIEDVAEEVAKIQKVLENGVDVTFDCAGFNKTITTALSAT 285
Query: 258 TPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPI 317
P G+V L+G+ ++++ + + + V GI TW L+SGK+++ P+
Sbjct: 286 RPGGKVCLVGMGQREMTLP----LATREIDVIGIF--RYQNTWPLCLEFLRSGKIDVKPL 339
Query: 318 ITHKYKGFD--KYEEAFEL-MRAGKTGKVVFML 347
ITH++ GF + EEAFE R G KV+F L
Sbjct: 340 ITHRF-GFSQKEVEEAFETSARGGNAIKVMFNL 371
>sp|Q57517|Y053_HAEIN HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN HI0053
>gi|1074240|pir||F64141 probable L-iditol
2-dehydrogenase (EC 1.1.1.14) HI0053 - Haemophilus
influenzae (strain Rd KW20) >gi|1573000|gb|AAC21731.1|
(U32690) zinc-type alcohol dehydrogenase [Haemophilus
influenzae Rd]
Length = 342
Score = 175 bits (438), Expect = 9e-43
Identities = 110/321 (34%), Positives = 175/321 (54%), Gaps = 10/321 (3%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
M E++ AI KP + EV P+ +VLI+V + ICG+D+ Y +
Sbjct: 1 MKERIKAICLEKPN-NVVVKEVPYPEKSDNDVLIQVESMGICGSDIGAYRGTN---PLVT 56
Query: 61 PPQIMGHEVAGEVVEVGPGV-EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV 119
P+I+GHE+ G V+E G G+ +G+ VGD V V+ ++ CG+CY C G+ + C++ K+ GV
Sbjct: 57 YPRILGHEIVGRVIESGIGMSDGVRVGDRVIVDPYVCCGQCYPCSIGRTNCCESLKVIGV 116
Query: 120 DTDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPI-SGKSVLITGAGP 178
DG E PA + K P ++P L EPL A+ + + SG+ ++I GAG
Sbjct: 117 HIDGGMQEVIRHPAHLLTKVPDNLPIHQLPLAEPLTIALHALHRTTLKSGEHIVIIGAGA 176
Query: 179 LGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVD 238
+GL+ A GA P++V + + R E AK +G ++++NP +ED +K + +IT G +
Sbjct: 177 IGLMAALAAVQYGAIPILV-DILEQRLEYAKSLGIEHIVNPHKEDDIKRIKEITSGRMAE 235
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWE 298
V +E SGA +++ L + AGR++L G +P + NLI FK L +YG R
Sbjct: 236 VVMEASGANISIKNTLHYASFAGRIALTG-WPKTETPLPTNLITFKELNIYG--SRTSKG 292
Query: 299 TWYTVSRLLQSGKLNLDPIIT 319
+ +L + K+N IIT
Sbjct: 293 EFEEALDMLATNKINASHIIT 313
>gb|AAA88523.1| (L47288) threonine dehydrogenase [Sinorhizobium meliloti]
Length = 222
Score = 173 bits (435), Expect = 2e-42
Identities = 91/222 (40%), Positives = 137/222 (60%), Gaps = 3/222 (1%)
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLL 182
G FAE+ +P NV P +P E A + +P GNAV T L+ + G+ VL+TGAGP+G++
Sbjct: 1 GSFAEFVCLPEYNVVSIPDDVPDEIAAIFDPFGNAVHTALSFDLVGEDVLVTGAGPIGIM 60
Query: 183 GIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLE 242
G VAK GA V++++ + R +LA+K+G D+V++ +E + + I G DV LE
Sbjct: 61 GAMVAKRCGARKVVITDINPVRLDLARKLGIDHVVDASKEKLADVMRVIGMTEGFDVGLE 120
Query: 243 FSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYT 302
SGA A + + G++++LG+ P ID+N +IFK L + GI GR ++ETWY
Sbjct: 121 MSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNK-VIFKMLNLKGIYGREMFETWYK 179
Query: 303 VSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+ +Q G L+L PIITH+ G D + + FE MR+G +GKVV
Sbjct: 180 MIAFVQGG-LDLSPIITHRI-GIDDFRDGFEAMRSGNSGKVV 219
>pir||T23889 hypothetical protein R04B5.5 - Caenorhabditis elegans
>gi|3878825|emb|CAA94841.1| (Z70782) contains similarity
to Pfam domain: PF00107 (Zinc-binding dehydrogenases),
Score=379.0, E-value=1.6e-110, N=1~cDNA EST EMBL:T00701
comes from this gene [Caenorhabditis elegans]
Length = 347
Score = 171 bits (429), Expect = 1e-41
Identities = 115/338 (34%), Positives = 174/338 (51%), Gaps = 14/338 (4%)
Query: 15 YGAE---LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAG 71
YG + L +V +PKPGP +VL+KV ICG+D+H + +K P I+GHE +G
Sbjct: 11 YGVDDLRLEQVPIPKPGPNQVLVKVHTVGICGSDVHYWTHGAIGPFVVKEPMIVGHETSG 70
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAV 130
V EVG V+ ++VGD +++E + C C C+ G+Y++C + F G + + V
Sbjct: 71 IVSEVGNEVKHLKVGDRIAMEPGLPCKLCEHCKTGRYNLCPEMRFFATPPVHGTLSRFVV 130
Query: 131 VPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKA 189
A +K P ++ E L EPL A+ G + G VL+ GAGP+G+L + AKA
Sbjct: 131 HDADFCFKLPDNLSFEDGALIEPLSVAIHACRRGNVQMGHRVLVLGAGPIGVLNLITAKA 190
Query: 190 SGAYPVIVSEPSDFRRELAKKVGADYVINPFEE--DVVK-EVMDITDGNGVDVFLEFSGA 246
GA V++++ D R LAKK+GAD IN + D VK E++ DV +E +GA
Sbjct: 191 VGAGKVVITDLDDGRLALAKKLGADATINVKGKSLDAVKSEIITALGDQQPDVCIECTGA 250
Query: 247 PKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY-TVSR 305
++E + G + L+GL +V I II A + G + Y T
Sbjct: 251 QPSIETAITTTKSGGVIVLVGLGADRVEIP----IIESATREVDMRGIFRYVNCYPTAIE 306
Query: 306 LLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
L+ SGKLNL + YK ++ +EAF+ + KV
Sbjct: 307 LISSGKLNLSGLTRAHYK-LEETQEAFKRTQKADVIKV 343
>dbj|BAA94084.1| (AB025969) NAD-dependent sorbitol dehydrogenase [Prunus persica]
Length = 367
Score = 170 bits (427), Expect = 2e-41
Identities = 113/334 (33%), Positives = 177/334 (52%), Gaps = 15/334 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P GP +V +K+ A ICG+D+H + + A ++ P ++GHE AG V EVG V+ +
Sbjct: 39 LPTVGPNDVRVKIKAVGICGSDVHYLKTMKCADFVVQEPMVIGHECAGIVDEVGSLVKNL 98
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVWKNPKS 142
GD V++E I C +C C+ G+Y++C + K F G A V PA +K P++
Sbjct: 99 VPGDRVALEPGISCWRCEQCKGGRYNLCPDMKFFATPPVHGSLANQIVHPADLCFKLPEN 158
Query: 143 IPPEYATLQEPLGNAVDTVLAGPISGK-SVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E + EPL V I + +VL+ GAGP+GL+ + A+A GA +++ +
Sbjct: 159 VSLEEGAMCEPLSVGVHACRRANIGPETNVLVIGAGPIGLVSVLSARAFGAARIVIVDVD 218
Query: 202 DFRRELAKKVGADYVI----NPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
D R +AK +GAD + NP + ED V ++ G GVDV + G K + L A
Sbjct: 219 DERLSIAKSLGADDAVKVSTNPQDLEDEVSKISKAMKG-GVDVSFDCVGFNKTMSTALSA 277
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
P G+V L+G+ G +++ + + V GI TW L++GK+++ P
Sbjct: 278 TRPGGKVCLVGMGHGVMTVPLTPAAA-REVDVVGIF--RYKNTWPLCLEFLRTGKIDVKP 334
Query: 317 IITHKYKGFD--KYEEAFEL-MRAGKTGKVVFML 347
+ITH++ GF + EEAFE R G KV+F L
Sbjct: 335 LITHRF-GFSQKEIEEAFETSARGGNAIKVMFNL 367
>pir||C83128 2,3-butanediol dehydrogenase PA4153 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9950359|gb|AAG07540.1|AE004831_12 (AE004831)
2,3-butanediol dehydrogenase [Pseudomonas aeruginosa]
Length = 363
Score = 169 bits (423), Expect = 5e-41
Identities = 114/345 (33%), Positives = 170/345 (49%), Gaps = 26/345 (7%)
Query: 7 AIMKTKPAYGAELVEV-DVP---KPGPGEVLIKVIATSICGTDLHIYEWNE--------W 54
A M+ +G + V DVP +P PG V I+V ICG+DLH Y
Sbjct: 9 AAMRAAVWHGRHDIRVEDVPLPAEPPPGWVQIRVHWCGICGSDLHEYLAGPVFIPVEAPH 68
Query: 55 AQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNT 114
+ +K I+GHE +GE+V +G GV G VG V+ + CG CY CR G Y++C+N
Sbjct: 69 PLTGLKDQCILGHEFSGEIVRLGNGVTGFAVGQAVAADACQHCGTCYYCRHGLYNICENL 128
Query: 115 KIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTV-LAGPISGKSVLI 173
G+ +G FAEY VPA ++ P P E L EPL + V AG + G++V++
Sbjct: 129 AFTGLMNNGAFAEYVNVPANLLYALPAGFPSEAGALIEPLAVGMHAVKKAGSLLGQNVVV 188
Query: 174 TGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITD 233
GAG +GL I A+A+GA VI E S R+ A +VGA V++P D + E+ +T
Sbjct: 189 VGAGTIGLSTIMCARAAGAAQVIALEMSSARKAKALEVGASQVLDPSRCDALGEIRALTG 248
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLI-----IFKALTV 288
G G DV E G + + A+ AG+ L+G++ +F L+ + AL
Sbjct: 249 GLGADVSFECIGNKHTAKLAIDAIRKAGKCVLVGIFEEPSEFNFFELVSTEKQLLGALAY 308
Query: 289 YGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFE 333
G + V + G+L++ P++T + + E FE
Sbjct: 309 NG--------EFADVIAFIADGRLDIAPLVTGRIGLEEIVERGFE 345
>gb|AAB58982.1| (L35343) 2,3-butanediol dehydrogenase [Pseudomonas putida]
>gi|1093520|prf||2104227E 2,3-butanediol dehydrogenase
[Pseudomonas putida]
Length = 362
Score = 167 bits (419), Expect = 2e-40
Identities = 103/307 (33%), Positives = 156/307 (50%), Gaps = 22/307 (7%)
Query: 27 PGPGEVLIKVIATSICGTDLHIYEWNE--------WAQSRIKPPQIMGHEVAGEVVEVGP 78
P PG V IKV ICG+DLH Y + I+ I+GHE G++ ++G
Sbjct: 31 PAPGWVQIKVDWCGICGSDLHEYVAGPVFIPVEAPHPLTGIQGQCILGHEFCGQIAKLGE 90
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWK 138
GVEG VGD V+ + CG CY C G Y++C+ G+ +G FAE VPA +++
Sbjct: 91 GVEGFAVGDPVAADACQHCGTCYYCTHGLYNICERLAFTGLMNNGAFAELVNVPANLLYR 150
Query: 139 NPKSIPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIV 197
P+ PPE L EPL + V AG + G++V++ GAG +GL I AKA+GA VI
Sbjct: 151 LPQGFPPEAGALIEPLAVGMHAVKKAGSLLGQTVVVVGAGTIGLCTIMCAKAAGAAQVIA 210
Query: 198 SEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV 257
E S R+ AK+VGA V++P + D + ++ +T G G DV E G + + +
Sbjct: 211 LEMSSARKAKAKEVGATVVLDPSQCDALAQIRALTFGLGADVSFECIGNKHTAKLAIDTI 270
Query: 258 TPAGRVSLLGLYPGKVSIDFNNLI-----IFKALTVYGITGRHLWETWYTVSRLLQSGKL 312
AG+ L+G++ +F L+ + AL G + V + G+L
Sbjct: 271 RKAGKCVLVGIFEEPSEFNFFELVSTEKQVLGALAYNG--------EFADVIAFIADGRL 322
Query: 313 NLDPIIT 319
++ P++T
Sbjct: 323 DIRPLVT 329
>sp|P38105|RSPB_ECOLI STARVATION SENSING PROTEIN RSPB >gi|2126057|pir||I81185
starvation-sensing protein rspB (EC 1.1.1.-) -
Escherichia coli >gi|495783|gb|AAA21686.1| (L31628)
putative [Escherichia coli] >gi|1742581|dbj|BAA15284.1|
(D90799) Starvation sensing protein RspB (EC 1.1.1.-).
[Escherichia coli] >gi|1742604|dbj|BAA15306.1| (D90800)
Starvation sensing protein RspB (EC 1.1.1.-).
[Escherichia coli] >gi|1787863|gb|AAC74652.1| (AE000254)
starvation sensing protein [Escherichia coli K12]
Length = 339
Score = 167 bits (419), Expect = 2e-40
Identities = 116/325 (35%), Positives = 172/325 (52%), Gaps = 21/325 (6%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEW-NEWAQSRIKPPQ 63
M +I+ KP A +VE ++P P GEV +KV ICG+D HIY N +A K P+
Sbjct: 1 MKSILIEKPNQLA-IVEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPFA----KYPR 55
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDG 123
++GHE G + VG GVE VG+ V+V+ + CG CY C G+ +VC + GV DG
Sbjct: 56 VIGHEFFGVIDAVGEGVESARVGERVAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADG 115
Query: 124 VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAG-PISGKSVLITGAGPLGLL 182
F+EYAVVPA+N WK P+++ +YA + EP A + G P +VL+ GAGP+GL
Sbjct: 116 GFSEYAVVPAKNAWKIPEAVADQYAVMIEPFTIAANVTGHGQPTENDTVLVYGAGPIGLT 175
Query: 183 GIAVAKASGAY---PVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDV 239
+ V K G Y VIV++ D R E AK+ GAD+ IN + + +I G+
Sbjct: 176 IVQVLK--GVYNVKNVIVADRIDERLEKAKESGADWAINNSQ----TPLGEIFTEKGIKP 229
Query: 240 FLEFSGA--PKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLW 297
L A P L++ + +PA R+ L+G + + S I K L+++ + R
Sbjct: 230 TLIIDAACHPSILKEAVTLASPAARIVLMG-FSSEPSEVIQQGITGKELSIF--SSRLNA 286
Query: 298 ETWYTVSRLLQSGKLNLDPIITHKY 322
+ V L G + + +ITH +
Sbjct: 287 NKFPIVIDWLSKGLIKPEKLITHTF 311
>dbj|BAB07668.1| (AP001520) L-iditol 2-dehydrogenase [Bacillus halodurans]
Length = 348
Score = 167 bits (418), Expect = 2e-40
Identities = 112/334 (33%), Positives = 172/334 (50%), Gaps = 18/334 (5%)
Query: 15 YGAELVEVD---VPKPGPGEVLIKVIATSICGTDLHIY--------EWNEWAQSRIKPPQ 63
+G + V VD P G+V IKV ICG+DLH Y + + + + K P
Sbjct: 7 HGVKDVRVDDIAEPATLKGKVKIKVKWCGICGSDLHEYAAGPIFIPQNSPHSLTEEKAPI 66
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTD 122
+MGHE +G+VVEVG GV E GD V VE CG C AC++G+Y++C+ G+
Sbjct: 67 VMGHEFSGQVVEVGDGVTKCEEGDRVVVEPIFACGTCTACKQGKYNLCEQLGFLGLAGGG 126
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGL 181
G F+EY V V K P ++ E L EP A+ V + G ++ G GP+GL
Sbjct: 127 GGFSEYVTVDEHMVHKIPDTVSFEQGALVEPAAVALYAVRQSQFNVGDQAVVFGTGPIGL 186
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
L I KASGA + E S RR+ A+++GA +NP E +VV+E+ +TDG G DV
Sbjct: 187 LVIEALKASGASKIYAVELSTERRQRAEQLGA-IALNPAEVNVVEEIQRLTDG-GADVSF 244
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY 301
E +G P L Q +++ G+ ++ ++ + S NL++ + + GI G + +
Sbjct: 245 EVTGVPIVLTQAIESTKLNGQTMIVSIFEKEASFQ-PNLVVMRERNIAGIIGYR--DIFP 301
Query: 302 TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELM 335
V L+ G + + ++T + D E+ FE +
Sbjct: 302 AVISLMNQGYFSAETLVTKRIGLHDIVEQGFEAL 335
>dbj|BAB11045.1| (AB015478) sorbitol dehydrogenase-like protein [Arabidopsis
thaliana]
Length = 364
Score = 162 bits (405), Expect = 7e-39
Identities = 106/333 (31%), Positives = 172/333 (50%), Gaps = 13/333 (3%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P GP +V +++ A ICG+D+H + A +K P ++GHE AG + EVG V+ +
Sbjct: 36 LPSVGPHDVRVRMKAVGICGSDVHYLKTMRCADFVVKEPMVIGHECAGIIEEVGEEVKHL 95
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVWKNPKS 142
VGD V++E I C +C CR G+Y++C K F G A V PA +K P++
Sbjct: 96 VVGDRVALEPGISCWRCNLCREGRYNLCPEMKFFATPPVHGSLANQVVHPADLCFKLPEN 155
Query: 143 IPPEYATLQEPLGNAVDTVLAGPISGK-SVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E + EPL V + + +VL+ GAGP+GL+ + A+A +++ +
Sbjct: 156 VSLEEGAMCEPLSVGVHACRRAEVGPETNVLVMGAGPIGLVTMLAARAFSVPRIVIVDVD 215
Query: 202 DFRRELAKKVGADYVINPFE--EDVVKEVMDITD--GNGVDVFLEFSGAPKALEQGLQAV 257
+ R +AK++GAD ++ EDV EV I G+ +DV + +G K + L A
Sbjct: 216 ENRLAVAKQLGADEIVQVTTNLEDVGSEVEQIQKAMGSNIDVTFDCAGFNKTMSTALAAT 275
Query: 258 TPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPI 317
G+V L+G+ G +++ + + V G+ TW L SGK+++ P+
Sbjct: 276 RCGGKVCLVGMGHGIMTVPLTPAAA-REVDVVGVF--RYKNTWPLCLEFLTSGKIDVKPL 332
Query: 318 ITHKYKGFD--KYEEAFELMRAGKTG-KVVFML 347
ITH++ GF + E+AFE G KV+F L
Sbjct: 333 ITHRF-GFSQKEVEDAFETSARGSNAIKVMFNL 364
>pir||T23890 hypothetical protein R04B5.6 - Caenorhabditis elegans
>gi|3878826|emb|CAA94842.1| (Z70782) contains similarity
to Pfam domain: PF00107 (Zinc-binding dehydrogenases),
Score=367.1, E-value=6e-107, N=1~cDNA EST yk446c9.5
comes from this gene~cDNA EST yk446c9.3 comes from this
gene [Caenorhabditis elegans]
Length = 347
Score = 159 bits (397), Expect = 6e-38
Identities = 100/332 (30%), Positives = 164/332 (49%), Gaps = 14/332 (4%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGP 78
L + + KPGP +VL+K+ ICG+D+H +K P ++GHE +G V E+G
Sbjct: 18 LEQAPISKPGPRQVLVKINTVGICGSDVHFLTHGAIGSFVVKEPMVLGHESSGVVSEIGS 77
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVW 137
V+G +VGD +++E + C C C+ G+Y++C + + F +G + + V A +
Sbjct: 78 EVKGFKVGDRIAMEPGLPCKLCEHCKIGRYNLCPDMRFFATPPVNGALSRFVVHDADFCF 137
Query: 138 KNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVI 196
K P ++ E L EPL A+ G + G+ +L+ GAGP+G+L + AKA GA V+
Sbjct: 138 KLPDNLSFEDGALLEPLSVAIQACRRGTVQMGQKILVLGAGPIGVLNLLTAKAIGASKVV 197
Query: 197 VSEPSDFRRELAKKVGADYVINPF---EEDVVKEVMDITDGNGVDVFLEFSGAPKALEQG 253
+++ +D R LA+ +GAD IN ++V E++ V +E +G +E
Sbjct: 198 ITDLNDERLALARLLGADATINVMGKRSDEVRSEIIKAFGDQQPHVSIECTGVQPCVETA 257
Query: 254 LQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY-TVSRLLQSGKL 312
+ G V L+GL +V I +I + G Y T L+ SGKL
Sbjct: 258 IMTTRSGGVVVLVGLGAERVEIP----LIQSPTREVDLRGTFRSANCYSTAIELISSGKL 313
Query: 313 NLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+L + Y K EE+ E + + G V+
Sbjct: 314 DLSGLTRAHY----KLEESLEAFKRTQNGDVI 341
>gi|8394334 sorbitol dehydrogenase [Rattus norvegicus]
>gi|57223|emb|CAA41761.1| (X59037) sorbitol
dehydrogenase [Rattus norvegicus]
Length = 357
Score = 159 bits (397), Expect = 6e-38
Identities = 106/329 (32%), Positives = 175/329 (52%), Gaps = 16/329 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+ GP +VL+K+ + ICG+D+H +E +K P ++GHE AG V +VGP V+ +
Sbjct: 27 IPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHL 86
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E + C+ G+Y++ IF T DG + A +K P
Sbjct: 87 KPGDRVAIEPGVPREIDEFCKIGRYNL--TPSIFFCATPPDDGNLCRFYKHSADFCYKLP 144
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
S+ E L EPL + G +S G VL+ GAGP+G++ + VAKA GA V+V +
Sbjct: 145 DSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVID 204
Query: 200 PSDFRRELAKKVGADYVINPFEE---DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK+VGAD+ I +E D+ K+V + G+ +V +E +GA +++ G+ A
Sbjct: 205 LSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVL-GSKPEVTIECTGAESSVQDGIYA 263
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLW-ETWYTVSRLLQSGKLNLD 315
G + ++G+ P +++ ++ A+ I G + TW +L S LN+
Sbjct: 264 THSGGTLVVVGMGPEMINLP----LVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVK 319
Query: 316 PIITHKYKGFDKYEEAFELMRAGKTGKVV 344
P++TH++ +K EAFE + G KV+
Sbjct: 320 PLVTHRFP-LEKAVEAFETAKKGLGLKVM 347
>sp|P27867|DHSO_RAT SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)
Length = 399
Score = 159 bits (397), Expect = 6e-38
Identities = 106/329 (32%), Positives = 175/329 (52%), Gaps = 16/329 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+ GP +VL+K+ + ICG+D+H +E +K P ++GHE AG V +VGP V+ +
Sbjct: 69 IPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHL 128
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E + C+ G+Y++ IF T DG + A +K P
Sbjct: 129 KPGDRVAIEPGVPREIDEFCKIGRYNL--TPSIFFCATPPDDGNLCRFYKHSADFCYKLP 186
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
S+ E L EPL + G +S G VL+ GAGP+G++ + VAKA GA V+V +
Sbjct: 187 DSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVID 246
Query: 200 PSDFRRELAKKVGADYVINPFEE---DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK+VGAD+ I +E D+ K+V + G+ +V +E +GA +++ G+ A
Sbjct: 247 LSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVL-GSKPEVTIECTGAESSVQDGIYA 305
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLW-ETWYTVSRLLQSGKLNLD 315
G + ++G+ P +++ ++ A+ I G + TW +L S LN+
Sbjct: 306 THSGGTLVVVGMGPEMINLP----LVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVK 361
Query: 316 PIITHKYKGFDKYEEAFELMRAGKTGKVV 344
P++TH++ +K EAFE + G KV+
Sbjct: 362 PLVTHRFP-LEKAVEAFETAKKGLGLKVM 389
>pir||S38363 L-iditol 2-dehydrogenase (EC 1.1.1.14) precursor - rat
>gi|7427633|pir||S16132 L-iditol 2-dehydrogenase (EC
1.1.1.14), long form - rat >gi|397357|emb|CAA52670.1|
(X74593) L-iditol 2-dehydrogenase [Rattus norvegicus]
Length = 399
Score = 158 bits (396), Expect = 8e-38
Identities = 106/329 (32%), Positives = 175/329 (52%), Gaps = 16/329 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+ GP +VL+K+ + ICG+D+H +E +K P ++GHE AG V +VGP V+ +
Sbjct: 69 IPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHL 128
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E + C+ G+Y++ IF T DG + A +K P
Sbjct: 129 KPGDRVAIEPGVPREIDEFCKIGRYNL--TPSIFFCATPPDDGNLCRFYKHSADFCYKLP 186
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
S+ E L EPL + G +S G VL+ GAGP+G++ + VAKA GA V+V +
Sbjct: 187 DSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVID 246
Query: 200 PSDFRRELAKKVGADYVINPFEE---DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK+VGAD+ I +E D+ K+V + G+ +V +E +GA +++ G+ A
Sbjct: 247 LSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVL-GSKPEVTIECTGAESSVQTGIYA 305
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLW-ETWYTVSRLLQSGKLNLD 315
G + ++G+ P +++ ++ A+ I G + TW +L S LN+
Sbjct: 306 THSGGTLVVVGMGPEMINLP----LVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVK 361
Query: 316 PIITHKYKGFDKYEEAFELMRAGKTGKVV 344
P++TH++ +K EAFE + G KV+
Sbjct: 362 PLVTHRFP-LEKAVEAFETAKKGLGLKVM 389
>sp|P39400|YJJN_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN IN
TSR-MDOB INTERGENIC REGION >gi|1361174|pir||S56585
L-iditol 2-dehydrogenase (EC 1.1.1.14) homolog yjjN -
Escherichia coli >gi|537201|gb|AAA97256.1| (U14003)
ORF_o345 [Escherichia coli] >gi|1790819|gb|AAC77314.1|
(AE000506) putative oxidoreductase [Escherichia coli
K12]
Length = 345
Score = 157 bits (394), Expect = 1e-37
Identities = 98/312 (31%), Positives = 160/312 (50%), Gaps = 9/312 (2%)
Query: 23 DVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEG 82
++P PG E LIK+ + ICGTD+H + N Q P+++GHE+ GE+V +G +
Sbjct: 26 EIPIPGDNEALIKIKSVGICGTDIHAWGGN---QPFFSYPRVLGHEICGEIVGLGKNIAD 82
Query: 83 IEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKS 142
++ G V+V ++ C +C AC+ G+ + C+ + GV DG F+EY VP N+
Sbjct: 83 LKNGQQVAVIPYVACQQCPACKSGRTNCCEKISVIGVHQDGGFSEYLSVPVANILP-ADG 141
Query: 143 IPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
I P+ A L EP + V I+ G+ VL+ GAGP+GL A+AKA GA V+V++ S
Sbjct: 142 IDPQAAALIEPFAISAHAVRRAAIAPGEQVLVVGAGPIGLGAAAIAKADGA-QVVVADTS 200
Query: 202 DFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAG 261
RRE +++P ED ++ G+ ++ +G A+ + + G
Sbjct: 201 PARREHVATRLELPLLDPSAEDFDAQLRAQFGGSLAQKVIDATGNQHAMNNTVNLIRHGG 260
Query: 262 RVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHK 321
V +GL+ G+ + F++ K T + E + V RL+ GK+ D ++TH+
Sbjct: 261 TVVFVGLFKGE--LQFSDPEFHKKETTMMGSRNATPEDFAKVGRLMAEGKITADMMLTHR 318
Query: 322 YKGFDKYEEAFE 333
Y F E +E
Sbjct: 319 YP-FATLAETYE 329
>emb|CAB61801.1| (AL133236) putative dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 344
Score = 157 bits (394), Expect = 1e-37
Identities = 106/327 (32%), Positives = 157/327 (47%), Gaps = 11/327 (3%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV +P+ PG L++V T ICGTDL I R + I+GHE++G V PG
Sbjct: 20 EVPMPEVPPGWALVRVACTGICGTDLGIVHGKH---PRARQGLILGHEISGWVEVTAPG- 75
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNP 140
G G V E I C C ACR G HVC +FG+D G A++ +P + + P
Sbjct: 76 -GPPEGALVVAEPLISCKDCRACREGHSHVCARLGLFGIDAPGGAAQFVALPTSTLHQVP 134
Query: 141 KSIPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
+ P A L EPL AV V +G +G V + GAGP+G+L VA+ GA V+V+E
Sbjct: 135 SRVEPTQAALTEPLAVAVHAVSRSGMEAGDVVAVFGAGPIGILTALVARHEGASHVVVAE 194
Query: 200 PSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTP 259
P+ RR +A +G + P + V +++ G+G D + + P +
Sbjct: 195 PNARRRAVASDMG--LIAVPDGAQLRDMVAELSQGDGADTTFDSAAHPAVAAELADVTRV 252
Query: 260 AGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIIT 319
GRV ++G+Y ++D + FK +V G+ + E + T L+ L LD
Sbjct: 253 LGRVVIVGVYKEPAAVDL-QAVCFKEQSVVGVR-VYTREDFRTAIDLVAQNALGLDRFPV 310
Query: 320 HKYKGFDKYEEAFELMRAGKTGKVVFM 346
Y GFD+ +AF+ G G V +
Sbjct: 311 SVY-GFDRISDAFDAAATGSGGLKVLI 336
>gb|AAC24597.1| (AF072541) xylitol dehydrogenase; XDH [Candida sp. HA167]
Length = 353
Score = 157 bits (392), Expect = 2e-37
Identities = 112/329 (34%), Positives = 171/329 (51%), Gaps = 12/329 (3%)
Query: 24 VPK-PGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEG 82
+PK P V I+V T ICG+D+H + +K P ++GHE +G V+EVG V+
Sbjct: 24 IPKLSDPYSVKIQVKKTGICGSDVHYFTHGAIGDFVVKAPMVLGHESSGVVLEVGSEVKS 83
Query: 83 IEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT-DGVFAEYAVVPAQNVWKNPK 141
++VGD V++E + + G+Y++C + DG +Y ++P K P+
Sbjct: 84 LKVGDRVAMEPGVPSRHSDEYKSGRYNLCPHMAFAATPPYDGTLCKYYILPEDFCVKLPE 143
Query: 142 SIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEP 200
+ E L EPL AV + G I G V I GAGP+GLL AVA A GA V + +
Sbjct: 144 HVSLEEGALVEPLSVAVHSSKLGNIKPGSHVAIYGAGPVGLLVAAVASAFGAESVTIIDL 203
Query: 201 SDFRRELAKKVGADYVINPFEEDVVKE----VMDITDGNGVDVFLEFSGAPKALEQGLQA 256
+ R LAK++GA + +D KE V+ +G DV ++ SGA ++ + A
Sbjct: 204 VESRLNLAKELGATATVQVDFKDTPKESAAKVVAANNGIAPDVVIDASGAEASINSAINA 263
Query: 257 VTPAGRVSLLGLYPGKVSIDFN-NLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLD 315
+ P G +G+ GK + F +I K LTV G + R+ + + LL SGK+N+
Sbjct: 264 IRPGGTYVQVGM--GKPDVSFPIATLIGKELTVKG-SFRYGYGDYPLAVSLLASGKVNVK 320
Query: 316 PIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+ITH+ K F+ EAF+L+R GK K +
Sbjct: 321 KLITHEVK-FEDAAEAFQLVRDGKAIKCI 348
>pir||B72381 alcohol dehydrogenase, zinc-containing - Thermotoga maritima
(strain MSB8) >gi|4980917|gb|AAD35497.1|AE001720_11
(AE001720) alcohol dehydrogenase, zinc-containing
[Thermotoga maritima]
Length = 395
Score = 155 bits (388), Expect = 7e-37
Identities = 113/354 (31%), Positives = 181/354 (50%), Gaps = 33/354 (9%)
Query: 23 DVPKPG---PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP----PQIMGHEVAGEVVE 75
+VP+P P E++IKV A ICG+D+H+ + +E P +GHE +G VVE
Sbjct: 44 EVPEPRIEKPTEIIIKVKACGICGSDVHMAQTDEEGYILYPGLTGFPVTLGHEFSGVVVE 103
Query: 76 VGPGV------EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYA 129
GP + E+G+ V E + CG C C G + C+N G + DG FAEY
Sbjct: 104 AGPEAINRRTNKRFEIGEPVCAEEMLWCGHCRPCAEGFPNHCENLNELGFNVDGAFAEYV 163
Query: 130 VVPAQNVWKNPKSIPPEY--------ATLQEPLGNAVDTVLA---GPISGKSVLITGAGP 178
V A+ W + + + Y +L EP A + V+ G G +V+I G GP
Sbjct: 164 KVDAKYAW-SLRELEGVYEGDRLFLAGSLVEPTSVAYNAVIVRGGGIRPGDNVVILGGGP 222
Query: 179 LGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVD 238
+GL +A+ K +GA VI+SEPS+ RR LAK++GAD+VI+P +E+ V+ V+D T+G G
Sbjct: 223 IGLAAVAILKHAGASKVILSEPSEVRRNLAKELGADHVIDPTKENFVEAVLDYTNGLGAK 282
Query: 239 VFLEFSGAPKALEQGLQAVTPAGR-----VSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
+FLE +G P+ + ++ V R V+++ K+ + + + + G G
Sbjct: 283 LFLEATGVPQLVWPQIEEVIWRARGINATVAIVARADAKIPLT-GEVFQVRRAQIVGSQG 341
Query: 294 RHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
T+ V L+ SG +++ II+ K ++ E + ++ K+ V ML
Sbjct: 342 HSGHGTFPRVISLMASG-MDMTKIIS-KTVSMEEIPEYIKRLQTDKSLVKVTML 393
>gb|AAK43330.1| Sorbitol dehydrogenase [Sulfolobus solfataricus]
Length = 345
Score = 154 bits (385), Expect = 2e-36
Identities = 110/336 (32%), Positives = 173/336 (50%), Gaps = 19/336 (5%)
Query: 17 AELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEV 76
A + E+ +PK G+VL+K+ A +CGTD+ Q P I+GHE G + E
Sbjct: 18 AVIKELPLPKLQQGDVLVKMKACGLCGTDIE----KICGQYTASQP-ILGHEPTGIIQE- 71
Query: 77 GPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNV 136
V+ ++ GD V H+ C +CY C++G +C + +D G F+EY VPA NV
Sbjct: 72 -STVDWLKPGDRVFAHHHVPCYECYYCKKGSPTMCPYYRKTNLDPGG-FSEYFRVPAWNV 129
Query: 137 -----WKNPKSIPPEYATLQEPLGNAVDTVLAGPI-SGKSVLITGAGPLGLLGIAVAKAS 190
K P ++ E EPL + I +G +V I G GP+GLL +AK +
Sbjct: 130 ARGGVLKLPDNVSFEEGAFIEPLATVIRAQKRVAIDNGDTVFIVGIGPMGLLHAMMAKVN 189
Query: 191 GAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKAL 250
A +I S+ SDFR E KVG +Y +N + +VV EV +TDG G DV + SG+P A+
Sbjct: 190 KAGVIIASDVSDFRTEFGYKVGINYSLNAKKVNVVDEVKRLTDGRGADVTIIASGSPSAI 249
Query: 251 EQGLQAVTPAGRVSLLGL-YPGKV-SIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQ 308
GL A GRV L G+ Y G + + D ++L+ + + + + E ++
Sbjct: 250 VSGLNATRKGGRVLLFGVPYKGTILNYDISDLLNNEISII--PSNAAVEEDTKEALAIIA 307
Query: 309 SGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+ K+++ +ITH++ D++ EA + + G KV+
Sbjct: 308 NKKIDVTKLITHRF-SLDEFNEAVRIGKEGNAIKVI 342
>pir||G70862 probable adhE2 protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2909565|emb|CAA17296.1| (AL021925) adhE2
[Mycobacterium tuberculosis]
Length = 361
Score = 151 bits (378), Expect = 1e-35
Identities = 113/375 (30%), Positives = 170/375 (45%), Gaps = 42/375 (11%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
MS+ + ++ + ELV + VP PGPGE ++ V A +C TDL E +
Sbjct: 1 MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYREGG----INDE 56
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC--------- 111
P ++GHE AG + VGPGV +E GD+V + VCG+C AC+RG+ C
Sbjct: 57 YPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRPRYCFDTFNAEQK 116
Query: 112 ----QNTKIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVL 162
T++ G FA+ +V + K + P A L LG A++T
Sbjct: 117 MTLTDGTELTAALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINT-- 174
Query: 163 AGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEE 222
G +V + G G +G IA A GA +I + D + + A+ GA + +N E
Sbjct: 175 GGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREV 234
Query: 223 DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLII 282
DVV+ + +TDG G DV ++ G P+ +Q A AG V L+G+ + +D +
Sbjct: 235 DVVQAIGGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPLVDF 294
Query: 283 FKALTVYGITGRHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAF 332
F G L +WY T+ L G+L L ++ + G + EEAF
Sbjct: 295 FS-------HGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERI-GLEDVEEAF 346
Query: 333 ELMRAGKTGKVVFML 347
M GK + V ML
Sbjct: 347 HKMHGGKVLRSVVML 361
>sp|P22144|XYL2_PICST D-XYLULOSE REDUCTASE (XYLITOL DEHYDROGENASE) (XDH)
>gi|82871|pir||S13529 D-xylulose reductase (EC 1.1.1.9)
- yeast (Pichia stipitis) >gi|3263|emb|CAA39066.1|
(X55392) Xylitol dehydrogenase [Pichia stipitis]
>gi|4704748|gb|AAD28251.1|AF127801_1 (AF127801) xylitol
dehydrogenase [Pichia stipitis]
Length = 363
Score = 151 bits (377), Expect = 1e-35
Identities = 107/329 (32%), Positives = 164/329 (49%), Gaps = 22/329 (6%)
Query: 29 PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDY 88
P +VL++V T ICG+D+H Y + P ++GHE AG VV+VG GV ++VGD
Sbjct: 28 PTDVLVQVKKTGICGSDIHFYAHGRIGNFVLTKPMVLGHESAGTVVQVGKGVTSLKVGDN 87
Query: 89 VSVETHIVCGKCYACRRGQYHVC--------QNTKIFGVDTDGVFAEYAVVPAQNVWKNP 140
V++E I + G Y++C N+K + G +Y P + K P
Sbjct: 88 VAIEPGIPSRFSDEYKSGHYNLCPHMAFAATPNSKEGEPNPPGTLCKYFKSPEDFLVKLP 147
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
+ E L EPL V G ++ G V + GAGP+GLL AVAK GA VIV +
Sbjct: 148 DHVSLELGALVEPLSVGVHASKLGSVAFGDYVAVFGAGPVGLLAAAVAKTFGAKGVIVVD 207
Query: 200 PSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTP 259
D + ++AK +GA + +E++ GN +V LE +GA ++ G+ A+ P
Sbjct: 208 IFDNKLKMAKDIGAATHTFNSKTGGSEELIKAFGGNVPNVVLECTGAEPCIKLGVDAIAP 267
Query: 260 AGRVSLLGLYPGKVSIDFNNLIIFKALTVYGI---------TGRHLWETWYTVSRLLQSG 310
GR +G G VS + K LT++G T +++T Y R ++
Sbjct: 268 GGRFVQVGNAAGPVSFPI-TVFAMKELTLFGSFRYGFNDYKTAVGIFDTNYQNGR--ENA 324
Query: 311 KLNLDPIITHKYKGFDKYEEAFELMRAGK 339
++ + +ITH+YK F EA++L+RAGK
Sbjct: 325 PIDFEQLITHRYK-FKDAIEAYDLVRAGK 352
>gb|AAD02817.1| (AF067126) NADP(H)-dependent ketose reductase [Bemisia
argentifolii]
Length = 352
Score = 151 bits (377), Expect = 1e-35
Identities = 107/333 (32%), Positives = 170/333 (50%), Gaps = 21/333 (6%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+P EVL+++ ICG+D+H YE A +K P ++GHE +G VV+VG V+ +
Sbjct: 23 IPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKVGKNVKHL 82
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVWKNPKS 142
+ GD V+VE + C +C C+ G+Y++C + DG A Y V A K P +
Sbjct: 83 KKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNLARYYVHAADFCHKLPDN 142
Query: 143 IPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E L EPL V AG G +VL+ GAGP+GL+ + AKA GA+ V+ + S
Sbjct: 143 VSLEEGALLEPLSVGVHACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARS 201
Query: 202 DFRRELAKKVGAD--YVINPF--EEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV 257
R E+AK GAD V++P EE + E + G+ +V ++ SG K + G+
Sbjct: 202 PRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINIT 261
Query: 258 TPAGRVSLLGLYPGKVSIDFNNL----IIFKALTVYGITGRHLWETWYTVSRLLQSGKLN 313
G + L+G+ V++ N I K++ Y + ++ SG+ N
Sbjct: 262 RTGGTLMLVGMGSQMVTVPLVNACAREIDIKSVFRY-------CNDYPIALEMVASGRCN 314
Query: 314 LDPIITHKYKGFDKYEEAFELMR--AGKTGKVV 344
+ ++TH +K ++ +AFE R A T KV+
Sbjct: 315 VKQLVTHSFK-LEQTVDAFEAARKKADNTIKVM 346
>sp|P77539|YDJL_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN IN
ANSA-GAPA INTERGENIC REGION >gi|7427645|pir||H64937
probable alcohol dehydrogenase (EC 1.1.1.-) -
Escherichia coli (strain K-12)
>gi|1742895|dbj|BAA15574.1| (D90821) Threonine
3-dehydrogenase (EC 1.1.1.103). [Escherichia coli]
>gi|1788075|gb|AAC74846.1| (AE000272) putative
oxidoreductase [Escherichia coli K12]
Length = 358
Score = 151 bits (377), Expect = 1e-35
Identities = 110/362 (30%), Positives = 182/362 (49%), Gaps = 30/362 (8%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKP--GPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
M A+ + A+G + +DVP+P GP +V+I++ A +ICG D+ Y + +
Sbjct: 1 MKALARFGKAFGGYKM-IDVPQPMCGPEDVVIEIKAAAICGADMKHYNVDSGSDEF---N 56
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGD-YVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT 121
I GHE AG + +VG V+ +VG VS + VCG C AC +G + C G+D
Sbjct: 57 SIRGHEFAGCIAQVGEKVKDWKVGQRVVSDNSGHVCGVCPACEQGDFLCCTEKVNLGLDN 116
Query: 122 D---GVFAEYAVVPAQ-------NVWKNPKSIPPEYATLQEPLGNAVDTVLAGP--ISGK 169
+ G F++Y +VP + +W+ P + E A + +P+ NA ++ + G+
Sbjct: 117 NTWGGGFSKYCLVPGEILKIHRHALWEIPDGVDYEDAAVLDPICNAYKSIAQQSKFLPGQ 176
Query: 170 SVLITGAGPLGLLGIAVAKASGAYPVIV---SEPSDFRRELAKKVGADYVINPFEEDVVK 226
V++ G GPLGL + +A+ GA ++V E R +AK++GA V+N EDVV
Sbjct: 177 DVVVIGTGPLGLFSVQMARIMGAVNIVVVGLQEDVAVRFPVAKELGATAVVNGSTEDVVA 236
Query: 227 EVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKAL 286
I + + + +E SGA AL+Q ++ + P G V +G+ + N++ +
Sbjct: 237 RCQQICGKDNLGLVIECSGANIALKQAIEMLRPNGEVVRVGMGFKPLDFSINDITAWNK- 295
Query: 287 TVYGITGRHLWE--TWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
I G ++ +W RLL SG + + P+ITH+ G ++ E F+ M KT V
Sbjct: 296 ---SIIGHMAYDSTSWRNAIRLLASGAIKVKPMITHRI-GLSQWREGFDAM-VDKTAIKV 350
Query: 345 FM 346
M
Sbjct: 351 IM 352
>pir||T36961 probable zinc-containing dehydrogenase - Streptomyces coelicolor
>gi|5748641|emb|CAB53146.1| (AL109962) putative
zinc-containing dehydrogenase [Streptomyces coelicolor
A3(2)]
Length = 356
Score = 151 bits (377), Expect = 1e-35
Identities = 110/326 (33%), Positives = 168/326 (50%), Gaps = 20/326 (6%)
Query: 23 DVPKPG---PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPG 79
D+P P P + +++V A +ICGTDLHI + + ++P ++GHE GE+VEVG
Sbjct: 16 DIPDPELKEPTDAIVRVDAVTICGTDLHILKGDV---PEVRPGTVLGHEAVGEIVEVGTD 72
Query: 80 VEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTK--IFGVDTDGVFAEYAVVPAQ--N 135
V + GD V V CG+C CR G Y C I G +G AEY VP +
Sbjct: 73 VRTVRPGDRVLVSCITACGRCRYCREGVYGQCLGGGGWILGHLINGTQAEYVRVPYADLS 132
Query: 136 VWKNPKSIPPEYATLQE---PLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASG 191
V P ++ E A L P V VL G +S G +V++ GAGP+GL +A A+
Sbjct: 133 VHSLPGAVTDEDAVLLADIFPTAYEVG-VLNGRVSPGDTVVVVGAGPIGLAAVATARLFA 191
Query: 192 AYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALE 251
++V + + R E A+K+GA+ V + ED + V D+T G G DV +E G P+ E
Sbjct: 192 PERIVVVDLATARLEAARKLGAEAVADA-REDPEQLVADLTGGLGADVVIEAVGVPETFE 250
Query: 252 QGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGK 311
+ V P G V+ +G++ ++ +L K +TV TG + T+ R+ SG+
Sbjct: 251 MCTRVVRPGGHVANVGVHGRPATLHLEDL-WSKNVTV--TTGLVDTRSTPTLLRMAASGR 307
Query: 312 LNLDPIITHKYKGFDKYEEAFELMRA 337
L ++TH + ++ EEA+E+ A
Sbjct: 308 LPTGQLVTHTFP-LERMEEAYEVFSA 332
>dbj|BAB03906.1| (AP001507) sorbitol dehydrogenase [Bacillus halodurans]
Length = 354
Score = 151 bits (377), Expect = 1e-35
Identities = 108/350 (30%), Positives = 166/350 (46%), Gaps = 18/350 (5%)
Query: 9 MKTKPAYGAELVEVD-VPKPG---PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
MK YG + + + P P +++IKV A ICG+DL Y+ P
Sbjct: 1 MKALNLYGIQDLRFEETPAPSIEHDDDIIIKVKAVGICGSDLSRYK----KLGPYVPGMT 56
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
GHE AGEVV++G V G +GD V+ CG+C C+ G+ C+ + G G
Sbjct: 57 FGHEFAGEVVKIGRSVTGFSIGDRVAACPTYTCGQCRYCQLGEPTRCERLSVIGARHPGA 116
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLG 183
+AEY +PA++V P + + A L EP I G SV I G G +GLL
Sbjct: 117 YAEYVKLPAKHVIPLPNVVNYDEAALIEPASVVAHGFYRTNIKPGASVAIMGVGSIGLLA 176
Query: 184 IAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEF 243
+ AK GA V + + + +A ++GAD +I+ + K++++ T+G GVDV +E
Sbjct: 177 VQWAKIFGATTVFAIDIDEQKLNVANQLGADVLISSLQRPAHKQILEYTNGIGVDVAVES 236
Query: 244 SGAPKALEQGLQAVTPAGRVSLLGLYPGKVSID--FNNLIIFKALTVYG----ITGRHLW 297
+G P Q G V LG+ V I+ + I+ L VYG ++
Sbjct: 237 AGTPSTSAQVFALPKKGGEVVFLGIPYADVQIERFYFEKIVRNELHVYGSWNALSSPFPG 296
Query: 298 ETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAG--KTGKVVF 345
+ W T + SG+LN+ P+I+++ K E F+ + G K KV+F
Sbjct: 297 KEWATTIHYMSSGQLNVAPMISYRLP-LAKGPETFQQIAKGELKPTKVLF 345
>sp|Q64442|DHSO_MOUSE SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)
>gi|2137466|pir||S65956 L-iditol 2-dehydrogenase (EC
1.1.1.14), long form - mouse (fragment)
>gi|1009706|gb|AAA79043.1| (U27014) sorbitol
dehydrogenase precursor [Mus musculus domesticus]
Length = 375
Score = 150 bits (376), Expect = 2e-35
Identities = 104/329 (31%), Positives = 173/329 (51%), Gaps = 16/329 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+ GP +VL+K+ + ICG+DLH +E +K P ++GHE AG V +VG V+ +
Sbjct: 45 IPELGPNDVLLKMHSVGICGSDLHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGELVKHL 104
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E + C+ G+Y++ IF T DG + A +K P
Sbjct: 105 KPGDRVAIEPGVPREVDEYCKIGRYNL--TPTIFFCATPPDDGNLCRFYKHNADFCYKLP 162
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
S+ E L EPL + G +S G VL+ GAGP+G++ + VAKA GA V+V++
Sbjct: 163 DSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPVGMVTLLVAKAMGAAQVVVTD 222
Query: 200 PSDFRRELAKKVGADYVINPFEE---DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK+VGAD+ I +E ++ +V + G+ +V +E +GA +++ G+ A
Sbjct: 223 LSASRLTKAKEVGADFTIQVGKETPQEIASKVESLL-GSKPEVTIECTGAESSVQSGIYA 281
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLW-ETWYTVSRLLQSGKLNLD 315
G + ++G+ V++ ++ A+ I G + TW +L S LN+
Sbjct: 282 THSGGTLVIVGMGAEMVNLP----LVHAAIREVDIKGVFRYCNTWPMAISMLASKTLNVK 337
Query: 316 PIITHKYKGFDKYEEAFELMRAGKTGKVV 344
P++TH++ +K EAFE + G KV+
Sbjct: 338 PLVTHRFP-LEKAVEAFETAKKGVGLKVM 365
>prf||2121217A sorbitol dehydrogenase [Homo sapiens]
Length = 357
Score = 150 bits (376), Expect = 2e-35
Identities = 97/328 (29%), Positives = 173/328 (52%), Gaps = 14/328 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+PGP EVL+++ + ICG+D+H +E+ +K P ++GHE +G V +VG V+ +
Sbjct: 27 IPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGDFIVKKPMVLGHEASGTVEKVGSSVKHL 86
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E C+ G+Y++ + IF T DG + A +K P
Sbjct: 87 KPGDRVAIEPGAPRENDEFCKMGRYNL--SPSIFFCATPPDDGNLCRFYKHNAAFCYKLP 144
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
++ E L EPL + G ++ G VL+ GAGP+G++ + VAKA GA V+V++
Sbjct: 145 DNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTD 204
Query: 200 PSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGN---GVDVFLEFSGAPKALEQGLQA 256
S R AK++GAD V+ ++ +E+ + +G +V +E +GA +++ G+ A
Sbjct: 205 LSATRLSKAKEIGADLVLQ-ISKESPQEIARLVEGQLGCKPEVTIECTGAEASIQAGIYA 263
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
G + L+GL ++ + I + + + G+ TW +L S +N+ P
Sbjct: 264 TRSGGTLVLVGLGSEMTTVPLLHAAI-REVDIKGVF--RYCNTWPVAISMLASKSVNVKP 320
Query: 317 IITHKYKGFDKYEEAFELMRAGKTGKVV 344
++TH++ +K EAFE + G K++
Sbjct: 321 LVTHRFP-LEKALEAFETFKKGLGLKIM 347
>sp|Q00796|DHSO_HUMAN SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)
>gi|496078|gb|AAA80565.1| (L29008) L-iditol-2
dehydrogenase [Homo sapiens] >gi|496086|gb|AAA80566.1|
(L29254) L-iditol-2 dehydrogenase [Homo sapiens]
Length = 357
Score = 150 bits (375), Expect = 2e-35
Identities = 98/328 (29%), Positives = 174/328 (52%), Gaps = 14/328 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+PGP EVL+++ + ICG+D+H +E+ +K P ++GHE +G V +VG V+ +
Sbjct: 27 IPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHL 86
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E C+ G+Y++ + IF T DG + A +K P
Sbjct: 87 KPGDRVAIEPGAPRENDEFCKMGRYNL--SPSIFFCATPPDDGNLCRFYKHNAAFCYKLP 144
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
++ E L EPL + G ++ G VL+ GAGP+G++ + VAKA GA V+V++
Sbjct: 145 DNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTD 204
Query: 200 PSDFRRELAKKVGADYVINPFEE---DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK++GAD V+ +E ++ ++V + G +V +E +GA +++ G+ A
Sbjct: 205 LSATRLSKAKEIGADLVLQISKESPQEIARKVEGLL-GCKPEVTIECTGAEASIQAGIYA 263
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
G + L+GL ++ + I + + + G+ TW +L S +N+ P
Sbjct: 264 TRSGGTLVLVGLGSEMTTVPLLHAAI-REVDIKGVF--RYCNTWPVAISMLASKSVNVKP 320
Query: 317 IITHKYKGFDKYEEAFELMRAGKTGKVV 344
++TH++ +K EAFE + G K++
Sbjct: 321 LVTHRFP-LEKALEAFETFKKGLGLKIM 347
>pir||H81925 probable alcohol dehydrogenase (EC 1.1.1.-) NMA0808 [similarity] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379528|emb|CAB84091.1| (AL162754) putative
zinc-binding alcohol dehydrogenase [Neisseria
meningitidis Z2491]
Length = 354
Score = 150 bits (375), Expect = 2e-35
Identities = 111/325 (34%), Positives = 170/325 (52%), Gaps = 18/325 (5%)
Query: 23 DVPKP--GPGEVLIKVIATSICGTDLHIYE---------WNEWAQSRIKPPQIMGHEVAG 71
D+P+P PG V I V ICGTDLH + + S P MGHE +G
Sbjct: 16 DIPEPTVAPGTVGINVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPVTMGHEFSG 75
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAV 130
V VG GV+ I+VG +V VE +I+ YH+ ++ G+ G +E
Sbjct: 76 VVYAVGEGVDDIKVGQHVVVEPYIIHDDVPTGEGSNYHLSKDMNFIGLGGCGGGLSEKIA 135
Query: 131 VPAQNVWKNPKSIPPEYATLQEPLGNAVDT-VLAGPISGKSVLITGAGPLGLLGIAVAKA 189
V + V IP + A L EPL V +G +G L+ GAGP+GLL AV KA
Sbjct: 136 VKRRWVHPISDKIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVGGAGPIGLLLAAVLKA 195
Query: 190 SGAYPVIVSEPSDFRRELAKKVG-ADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPK 248
G VI++E S R++ A++ G ADY+++P E DVV+EV +T+G GVDV E + K
Sbjct: 196 KG-IKVIITELSKARKDKARESGVADYILDPSEVDVVEEVKKLTNGEGVDVAFECTSVNK 254
Query: 249 ALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQ 308
L+ ++A PA + ++ ++ +++ ++ ++ K L V G T + + T+ +L++
Sbjct: 255 VLDTLVEACKPAANLVIVSIWSHPATVNVHS-VVMKELDVRG-TIAYCNDHAETI-KLVE 311
Query: 309 SGKLNLDPIITHKYKGFDKYEEAFE 333
GK+NL+P IT + K + E FE
Sbjct: 312 EGKINLEPFITQRIKLDELVSEGFE 336
>gi|4507155 sorbitol dehydrogenase [Homo sapiens] >gi|1082564|pir||A54674
L-iditol 2-dehydrogenase (EC 1.1.1.14) - human
>gi|520450|gb|AAA66064.1| (U07361) sorbitol
dehydrogenase [Homo sapiens] >gi|1755138|gb|AAB61898.1|
(U67243) sorbitol dehydrogenase [Homo sapiens]
Length = 357
Score = 149 bits (372), Expect = 5e-35
Identities = 97/327 (29%), Positives = 170/327 (51%), Gaps = 12/327 (3%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+PGP EVL+++ + ICG+D+H +E+ +K P ++GHE +G V +VG V+ +
Sbjct: 27 IPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHL 86
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E C+ G+Y++ + IF T DG + A +K P
Sbjct: 87 KPGDRVAIEPGAPRENDEFCKMGRYNL--SPSIFFCATPPDDGNLCRFYKHNAAFCYKLP 144
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
++ E L EPL + G ++ G VL+ GAGP+G++ + VAKA GA V+V++
Sbjct: 145 DNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTD 204
Query: 200 PSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGV--DVFLEFSGAPKALEQGLQAV 257
S R AK++GAD V+ +E + + G +V +E +GA +++ G+ A
Sbjct: 205 LSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYAT 264
Query: 258 TPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPI 317
G + L+GL ++ + I + + + G+ TW +L S +N+ P+
Sbjct: 265 RSGGTLVLVGLGSEMTTVPLLHAAI-REVDIKGVF--RYCNTWPVAISMLASKSVNVKPL 321
Query: 318 ITHKYKGFDKYEEAFELMRAGKTGKVV 344
+TH++ +K EAFE + G K++
Sbjct: 322 VTHRFP-LEKALEAFETFKKGLGLKIM 347
>gi|11432526 sorbitol dehydrogenase [Homo sapiens]
Length = 357
Score = 148 bits (369), Expect = 1e-34
Identities = 96/327 (29%), Positives = 169/327 (51%), Gaps = 12/327 (3%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+PGP EVL+++ + ICG+D+H +E+ +K P ++GHE +G V +VG + +
Sbjct: 27 IPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSAKHL 86
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E C+ G+Y++ + IF T DG + A +K P
Sbjct: 87 KPGDRVAIEPGAPRENDEFCKMGRYNL--SPSIFFCATPPDDGNLCRFYKHNAAFCYKLP 144
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
++ E L EPL + G ++ G VL+ GAGP+G++ + VAKA GA V+V++
Sbjct: 145 DNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTD 204
Query: 200 PSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGV--DVFLEFSGAPKALEQGLQAV 257
S R AK++GAD V+ +E + + G +V +E +GA +++ G+ A
Sbjct: 205 LSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYAT 264
Query: 258 TPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPI 317
G + L+GL ++ + I + + + G+ TW +L S +N+ P+
Sbjct: 265 RSGGNLVLVGLGSEMTTVPLLHAAI-REVDIKGVF--RYCNTWPVAISMLASKSVNVKPL 321
Query: 318 ITHKYKGFDKYEEAFELMRAGKTGKVV 344
+TH++ +K EAFE + G K++
Sbjct: 322 VTHRFP-LEKALEAFETFKKGLGLKIM 347
>pir||E81178 probable alcohol dehydrogenase (EC 1.1.1.-) NMB0604 [similarity] -
Neisseria meningitidis (group B strain MD58)
>gi|7225834|gb|AAF41031.1| (AE002416) alcohol
dehydrogenase, zinc-containing [Neisseria meningitidis
MC58]
Length = 354
Score = 148 bits (369), Expect = 1e-34
Identities = 111/325 (34%), Positives = 168/325 (51%), Gaps = 18/325 (5%)
Query: 23 DVPKP--GPGEVLIKVIATSICGTDLHIYE---------WNEWAQSRIKPPQIMGHEVAG 71
D+P+P PG V I V ICGTDLH + + S P MGHE +G
Sbjct: 16 DIPEPTVAPGTVGINVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPVTMGHEFSG 75
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAV 130
V VG GV+ I+VG +V VE +I+ YH+ ++ G+ G +E
Sbjct: 76 VVYAVGEGVDDIKVGQHVVVEPYIIRDDVPTGEGSNYHLSKDMNFIGLGGCGGGLSEKIA 135
Query: 131 VPAQNVWKNPKSIPPEYATLQEPLGNAVDT-VLAGPISGKSVLITGAGPLGLLGIAVAKA 189
V + V IP + A L EPL V +G G L+ GAGP+GLL AV KA
Sbjct: 136 VKRRWVHPISDKIPLDQAALIEPLSVGHHAYVRSGAKEGDVALVGGAGPIGLLLAAVLKA 195
Query: 190 SGAYPVIVSEPSDFRRELAKKVG-ADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPK 248
G VI++E S R++ A++ G ADY+++P E DVV EV +T+G GVDV E + K
Sbjct: 196 KG-IKVIITELSKARKDKARESGVADYILDPSEVDVVAEVKKLTNGEGVDVAFECTSVNK 254
Query: 249 ALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQ 308
L+ ++A PA + ++ ++ +I+ ++ ++ K L V G T + + T+ +L++
Sbjct: 255 VLDTLVEACKPAANLVIVSIWSHPATINVHS-VVMKELDVRG-TIAYCNDHAETI-KLVE 311
Query: 309 SGKLNLDPIITHKYKGFDKYEEAFE 333
GK+NL+P IT + K + + FE
Sbjct: 312 EGKINLEPFITQRIKLDELVSKGFE 336
>pir||H69789 probable alcohol dehydrogenase (EC 1.1.1.-) ydjL [similarity] -
Bacillus subtilis >gi|2522016|dbj|BAA22767.1| (AB007638)
dehydrogenase [Bacillus subtilis]
>gi|2632937|emb|CAB12443.1| (Z99107) similar to L-iditol
2-dehydrogenase [Bacillus subtilis]
Length = 346
Score = 148 bits (369), Expect = 1e-34
Identities = 111/321 (34%), Positives = 160/321 (49%), Gaps = 18/321 (5%)
Query: 22 VDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--------PQIMGHEVAGEV 73
++ PK PG+V IKV ICG+DLH Y KP P MGHE +GEV
Sbjct: 17 IEEPKTEPGKVKIKVKWCGICGSDLHEYLGGPIFIPVDKPHPLTNETAPVTMGHEFSGEV 76
Query: 74 VEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVP 132
VEVG GVE +VGD V VE +G Y++ + G+ G F+EY V
Sbjct: 77 VEVGEGVENYKVGDRVVVEPIFATHG----HQGAYNLDEQMGFLGLAGGGGGFSEYVSVD 132
Query: 133 AQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPI-SGKSVLITGAGPLGLLGIAVAKASG 191
+ ++K P + E L EP A+ V + + +G + G GP+GLL I KA+G
Sbjct: 133 EELLFKLPDELSYEQGALVEPSAVALYAVRSSKLKAGDKAAVFGCGPIGLLVIEALKAAG 192
Query: 192 AYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALE 251
A + E S R++ A+++GA V +DVV E+ + T G GVDV E +G P L
Sbjct: 193 ATDIYAVELSPERQQKAEELGAIIVDPSKTDDVVAEIAERT-GGGVDVAFEVTGVPVVLR 251
Query: 252 QGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGK 311
Q +Q+ T AG ++ ++ I N+++I K TV GI G + + V L++ G
Sbjct: 252 QAIQSTTIAGETVIVSIWEKGAEIHPNDIVI-KERTVKGIIGYR--DIFPAVLSLMKEGY 308
Query: 312 LNLDPIITHKYKGFDKYEEAF 332
+ D ++T K D EE F
Sbjct: 309 FSADKLVTKKIVLDDLIEEGF 329
>sp|P77280|YDJJ_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN IN
ANSA-GAPA INTERGENIC REGION >gi|7427635|pir||F64937
probable L-iditol 2-dehydrogenase (EC 1.1.1.14) b1774 -
Escherichia coli (strain K-12)
>gi|1742893|dbj|BAA15572.1| (D90821) Sorbitol
dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).
[Escherichia coli] >gi|1788073|gb|AAC74844.1| (AE000272)
putative oxidoreductase [Escherichia coli K12]
Length = 347
Score = 147 bits (368), Expect = 2e-34
Identities = 91/321 (28%), Positives = 159/321 (49%), Gaps = 11/321 (3%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI-MGHEVAGEVVEV 76
+++ ++P P EVLIKV ICG+D+H +E + + +I +GHE AG VV V
Sbjct: 15 KIISAEIPVPKEDEVLIKVEYVGICGSDVHGFESGPFIPPKDPNQEIGLGHECAGTVVAV 74
Query: 77 GPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD--GVFAEYAVVPAQ 134
G V + GD V++E + CG C C G+Y++C + + G Y P
Sbjct: 75 GSRVRKFKPGDRVNIEPGVPCGHCRYCLEGKYNICPDVDFMATQPNYRGALTHYLCHPES 134
Query: 135 NVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAY 193
+K P ++ L EP + + + GK ++I GAG +GL+ + K GA
Sbjct: 135 FTYKLPDNMDTMEGALVEPAAVGMHAAMLADVKPGKKIIILGAGCIGLMTLQACKCLGAT 194
Query: 194 PVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQG 253
+ V + + R +A+++GA VIN +ED + T+ G D+ E +G+ ++Q
Sbjct: 195 EIAVVDVLEKRLAMAEQLGATVVINGAKEDTIARCQQFTEDMGADIVFETAGSAVTVKQA 254
Query: 254 LQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVS-RLLQSGKL 312
V G++ ++G PG +I+F L I + +T+ + + Y V+ + SG+
Sbjct: 255 PYLVMRGGKIMIVGTVPGDSAINF--LKINREVTIQTV---FRYANRYPVTIEAISSGRF 309
Query: 313 NLDPIITHKYKGFDKYEEAFE 333
++ ++TH Y + ++AFE
Sbjct: 310 DVKSMVTHIY-DYRDVQQAFE 329
>sp|P07846|DHSO_SHEEP SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)
Length = 354
Score = 147 bits (368), Expect = 2e-34
Identities = 103/329 (31%), Positives = 171/329 (51%), Gaps = 17/329 (5%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+PGP EVL+K+ + ICG+D+H ++ +K P ++GHE +G VV+VG V +
Sbjct: 25 IPEPGPNEVLLKMHSVGICGSDVHYWQ-GRIGDFVVKKPMVLGHEASGTVVKVGSLVRHL 83
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V+++ C+ G+Y++ + IF T DG + A +K P
Sbjct: 84 QPGDRVAIQPGAPRQTDEFCKIGRYNL--SPTIFFCATPPDDGNLCRFYKHNANFCYKLP 141
Query: 141 KSIPPEYATLQEPLGNAVDTVL-AGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
++ E L EPL + AG G VL+ GAGP+GL+ + AKA GA V+V++
Sbjct: 142 DNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGLVNLLAAKAMGAAQVVVTD 201
Query: 200 PSDFRRELAKKVGADYVI---NPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK+VGAD+++ N E++ K+V + G+ +V +E +G +++ G+ A
Sbjct: 202 LSASRLSKAKEVGADFILEISNESPEEIAKKVEGLL-GSKPEVTIECTGVETSIQAGIYA 260
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLW-ETWYTVSRLLQSGKLNLD 315
G + L+GL S+ ++ A I G + TW +L S +N+
Sbjct: 261 THSGGTLVLVGLGSEMTSVP----LVHAATREVDIKGVFRYCNTWPMAISMLASKSVNVK 316
Query: 316 PIITHKYKGFDKYEEAFELMRAGKTGKVV 344
P++TH++ +K EAFE + G KV+
Sbjct: 317 PLVTHRFP-LEKALEAFETSKKGLGLKVM 344
>pir||S10065 L-iditol 2-dehydrogenase (EC 1.1.1.14) - sheep (tentative sequence)
Length = 354
Score = 147 bits (368), Expect = 2e-34
Identities = 103/329 (31%), Positives = 171/329 (51%), Gaps = 17/329 (5%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+PGP EVL+K+ + ICG+D+H ++ +K P ++GHE +G VV+VG V +
Sbjct: 25 IPEPGPNEVLLKMHSVGICGSDVHYWQ-GRIGBFVVKKPMVLGHEASGTVVKVGSLVRHL 83
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V+++ C+ G+Y++ + IF T DG + A +K P
Sbjct: 84 QPGDRVAIQPGAPRQTDEFCKIGRYNL--SPTIFFCATPPDDGNLCRFYKHNANFCYKLP 141
Query: 141 KSIPPEYATLQEPLGNAVDTVL-AGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
++ E L EPL + AG G VL+ GAGP+GL+ + AKA GA V+V++
Sbjct: 142 DNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGLVNLLAAKAMGAAQVVVTD 201
Query: 200 PSDFRRELAKKVGADYVI---NPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK+VGAD+++ N E++ K+V + G+ +V +E +G +++ G+ A
Sbjct: 202 LSASRLSKAKEVGADFILEISNESPEEIAKKVEGLL-GSKPEVTIECTGVETSIQAGIYA 260
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLW-ETWYTVSRLLQSGKLNLD 315
G + L+GL S+ ++ A I G + TW +L S +N+
Sbjct: 261 THSGGTLVLVGLGSEMTSVP----LVHAATREVDIKGVFRYCNTWPMAISMLASKSVNVK 316
Query: 316 PIITHKYKGFDKYEEAFELMRAGKTGKVV 344
P++TH++ +K EAFE + G KV+
Sbjct: 317 PLVTHRFP-LEKALEAFETSKKGLGLKVM 344
>gb|AAB69288.1| (AF010494) sorbitol dehydrogenase [Callithrix sp.]
Length = 357
Score = 146 bits (365), Expect = 3e-34
Identities = 99/328 (30%), Positives = 173/328 (52%), Gaps = 14/328 (4%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+PGP EVL+++ + ICG+D+H ++ +K P ++GHE +G VV+VG V+ +
Sbjct: 27 IPEPGPNEVLLRIHSVGICGSDVHYWQHGRIGDFIVKKPMVLGHEASGRVVKVGSLVKHL 86
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---DGVFAEYAVVPAQNVWKNP 140
+ GD V++E C+ G+Y++ + IF T DG + A +K P
Sbjct: 87 KPGDRVAIEPGAPRETDEFCKTGRYNL--SPTIFFCATPPDDGNLCRFYKHNAAFCYKLP 144
Query: 141 KSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSE 199
++ E L EPL + G ++ G VL+ GAGP+GL+ + VAKA GA V+V++
Sbjct: 145 DNVTFEEGALIEPLSVGIHACRRGGVALGNKVLVCGAGPIGLVTLLVAKAMGASQVVVTD 204
Query: 200 PSDFRRELAKKVGADYVINPFEE---DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
S R AK++GAD+ + +E ++ +V + G +V +E +GA +++ G+ A
Sbjct: 205 LSAPRLSKAKEIGADFSLQISKESPQEIASKVEGLL-GCKPEVTIECTGAEASIQAGIYA 263
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
G + L+GL ++ + + + + G+ TW +L+S +NL P
Sbjct: 264 TRSGGTLVLVGLGSEMTTVPLVHATT-REVDIKGVF--RYSNTWPMAISMLESKSVNLMP 320
Query: 317 IITHKYKGFDKYEEAFELMRAGKTGKVV 344
++TH++ +K EAFE + G KV+
Sbjct: 321 LVTHRFP-LEKALEAFETSKKGLGLKVM 347
>emb|CAC14943.1| (AL449216) putative oxidoreductase [Streptomyces coelicolor]
Length = 362
Score = 146 bits (365), Expect = 3e-34
Identities = 112/358 (31%), Positives = 166/358 (46%), Gaps = 53/358 (14%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVEVGPGVE 81
VP PGPGE ++K+ A +C TDLH + Q I P ++GHE AG V VG GV
Sbjct: 24 VPDPGPGEAVVKIQACGVCHTDLH------YKQGGINDEFPFLLGHEAAGVVESVGAGVT 77
Query: 82 GIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTK-----------------IFGVDTDGV 124
+ GD+V + VCGKC ACRRG+ C +T G+ G
Sbjct: 78 DVAPGDFVILNWRAVCGKCRACRRGRPWYCFDTHNAEQRMTLASTGQELSPALGI---GA 134
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLITGAGPL 179
FAE +V A K ++P E A L +G A++T G G +V + G G +
Sbjct: 135 FAEKTLVAAGQCTKVDPAVPAEVAGLLGCGVMAGIGAAINTGNVG--RGDTVAVIGCGGV 192
Query: 180 GLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDV 239
G IA + +GA VI + D + E A+ +GA + +N D V+ + ++T G G DV
Sbjct: 193 GDAAIAGSYLAGASKVIAVDIDDRKLETARTMGATHTVNSRGTDPVEAIRELTGGFGADV 252
Query: 240 FLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWET 299
+E G P+ Q A AG V L+G+ ++ ++ L +F G L +
Sbjct: 253 VIEAVGRPETYRQAFYARDLAGTVVLVGVPTPEMKLELPLLDVFG-------RGGSLKSS 305
Query: 300 WY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
WY + L G+L+L +T + D+ E+AF+ M AG + V +L
Sbjct: 306 WYGDCLPSRDFPMLVDLHLQGRLDLGKFVTETIR-LDEVEQAFDRMHAGDVLRSVVVL 362
>pir||T36915 probable zinc-binding dehydrogenase - Streptomyces coelicolor
>gi|5420010|emb|CAB46402.1| (AL096743) putative
zinc-binding dehydrogenase [Streptomyces coelicolor
A3(2)]
Length = 329
Score = 145 bits (361), Expect = 1e-33
Identities = 111/332 (33%), Positives = 168/332 (50%), Gaps = 21/332 (6%)
Query: 17 AELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEV 76
A + EV P PGP EV+++V A +CGTDLHI + E+A K P + GHE AG VV V
Sbjct: 12 AVVTEVPDPTPGPREVVVEVAACGLCGTDLHILQ-GEFAP---KLPIVPGHEFAGAVVGV 67
Query: 77 GPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNV 136
G V + VGD V+V+ + C +C CR G ++C+ GV T G A+YAV P N
Sbjct: 68 GAQVTEVAVGDQVAVDPSLYCYECRYCRTGHNNLCERWAAIGVTTAGGAAQYAVAPVANC 127
Query: 137 WKNPKSIPPEYATLQEPLGNAVD--TVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYP 194
K P+ + + A L EPL AV VL + G VLI G+G +GL+ + +AK +GA
Sbjct: 128 VKLPEHVRTQDAALIEPLSCAVRGYDVLQSRL-GAHVLIYGSGTMGLMMLELAKRTGAAS 186
Query: 195 VIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGL 254
V + + + R E A+ +G +E + G D+ ++ +G A++ GL
Sbjct: 187 VDMVDLNPARLETARGLGVSASAATPDE--------LDRPQGWDLVIDATGNAAAIQDGL 238
Query: 255 QAVTPAGRVSLLGL--YPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKL 312
V AG G+ Y +V ID I + +T+ G + ++ + L +G L
Sbjct: 239 DRVAKAGTFLQFGVADYATRVQID-PYRIYNQEITITG--SMAVLHSYERAAELFANGVL 295
Query: 313 NLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+ D I+ + + +Y +A E AG K+V
Sbjct: 296 DPDVFISDRIE-LARYPQALEQFAAGVGRKIV 326
>pir||B83133 probable alcohol dehydrogenase (Zn-dependent) PA4097 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9950298|gb|AAG07484.1|AE004826_2 (AE004826) probable
alcohol dehydrogenase (Zn-dependent) [Pseudomonas
aeruginosa]
Length = 352
Score = 143 bits (358), Expect = 2e-33
Identities = 98/331 (29%), Positives = 163/331 (48%), Gaps = 16/331 (4%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWA--------QSRIKPPQIMGHEVA 70
L E++ P PGEV ++V ICG+DLH Y+ + S + P +GHE
Sbjct: 14 LSELERQAPRPGEVELEVAYCGICGSDLHEYQSGPHSIPQAEAHPLSGCRAPLTLGHEFC 73
Query: 71 GEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAV 130
G V +GPGVEG +GD V+VE CG+C CR G+Y++C++ G+ DG FAE A
Sbjct: 74 GVVAALGPGVEGPRIGDRVAVEPEYRCGECRYCREGRYNLCESMGFIGLMGDGGFAERAR 133
Query: 131 VPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKA 189
VPA + + P ++ A + EP A+ + ++ G+ + G GP+GLL + +A+
Sbjct: 134 VPAYMLHRLPDAVGFRQAAVLEPAAVALHALRRSSLAPGQRCAVFGLGPIGLLLVMLARL 193
Query: 190 SGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKA 249
G + + S R LA + GA ++ + D + +G +D E +G+ +
Sbjct: 194 RGIEDIAAVDVSPERLALAGEFGASRALDARDGDTAAR---LREGGALDCAFEAAGSQAS 250
Query: 250 LEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQS 309
L+ L ++ G + L+ L G+V +D +L + + L + G G + + + LL
Sbjct: 251 LDAALASLRKGGELVLVSLM-GEVRLDAFDL-VNRELRLLGSVGYR--DAYPELIALLAD 306
Query: 310 GKLNLDPIITHKYKGFDKYEEAFELMRAGKT 340
G+L+L +T E FE + K+
Sbjct: 307 GRLDLARAVTRSVPLEQAVEHGFEALLRDKS 337
>sp|P50381|ADH3_SULSO NAD-DEPENDENT ALCOHOL DEHYDROGENASE >gi|1085620|pir||S51120 alcohol
dehydrogenase (EC 1.1.1.1) - Sulfolobus sp
>gi|623348|emb|CAA87591.1| (Z47543) alcohol
dehydrogenase [Sulfolobus sp.]
Length = 347
Score = 143 bits (357), Expect = 3e-33
Identities = 96/316 (30%), Positives = 159/316 (49%), Gaps = 18/316 (5%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRI------KPPQIMGHEVAGE 72
L ++D+PKP +VLIKV A +C +D+H+ + + RI K P +GHE+AG+
Sbjct: 15 LKDIDIPKPKGAQVLIKVEAAGVCHSDVHMRQ-GRFGNLRIVEDLGVKLPVTLGHEIAGK 73
Query: 73 VVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVP 132
+ E+G V G GD V+V G CY CR G+ H+C + + G++ DG +AEY + P
Sbjct: 74 IEEMGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVLNP 133
Query: 133 AQNVWKNPKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITGA-GPLGLLGIAVA 187
+ + A+ G AV P K++++ GA G LG + + +A
Sbjct: 134 HYKYMYKLRRLNAVEASPLTCSGITTYRAVRKASLDPT--KTLVVVGAGGGLGTMAVQIA 191
Query: 188 KASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAP 247
KA G +I + + E AK+ GADYVIN +D + E+ IT+G GVD ++ + +
Sbjct: 192 KAVGGATIIGVDVREEAVETAKRAGADYVINASVQDPLAEIRRITEGKGVDAVIDLNNSE 251
Query: 248 KALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLL 307
K L +A+ G+ ++GL+ + + + + V + G + + RL
Sbjct: 252 KTLSVYPKALAKQGKYIMVGLFGADLHFHAPLITLSEIQFVGSLVGNQ--SDFLGIMRLA 309
Query: 308 QSGKLNLDPIITHKYK 323
++GK+ P+IT K
Sbjct: 310 EAGKVK--PMITKTMK 323
>gb|AAK42665.1| Alcohol dehydrogenase (Zn containing) (adh-10) [Sulfolobus
solfataricus]
Length = 347
Score = 141 bits (353), Expect = 9e-33
Identities = 98/316 (31%), Positives = 156/316 (49%), Gaps = 18/316 (5%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRI------KPPQIMGHEVAGE 72
L E+ VPKP +VLIKV A +C +D+H+ + + RI K P +GHE+AG+
Sbjct: 15 LQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQ-GRFGNLRIVEDLGVKLPVTLGHEIAGK 73
Query: 73 VVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVP 132
+ EVG V G GD V+V G CY CR G+ H+C + + G++ DG +AEY +VP
Sbjct: 74 IEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVP 133
Query: 133 AQNVWKNPKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITGA-GPLGLLGIAVA 187
+ + A G AV P K++L+ GA G LG + + +A
Sbjct: 134 HYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPT--KTLLVVGAGGGLGTMAVQIA 191
Query: 188 KASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAP 247
KA +I + + E AK+ GADYVIN +D + E+ IT+ GVD ++ + +
Sbjct: 192 KAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSE 251
Query: 248 KALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLL 307
K L +A+ G+ ++GL+ + + + + V + G + + RL
Sbjct: 252 KTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQ--SDFLGIMRLA 309
Query: 308 QSGKLNLDPIITHKYK 323
++GK+ P+IT K
Sbjct: 310 EAGKVK--PMITKTMK 323
>sp|P39462|ADH1_SULSO NAD-DEPENDENT ALCOHOL DEHYDROGENASE >gi|322356|pir||A44245 alcohol
dehydrogenase (EC 1.1.1.1) - Sulfolobus solfataricus
>gi|261969|gb|AAB24546.1| (S51211) NAD(+)-dependent
alcohol dehydrogenase, SSADH {EC 1.1.1.1} [Sulfolobus
solfataricus, DSM1617, Peptide, 347 aa]
>gi|3947748|emb|CAA09258.1| (AJ010590) alcohol
dehydrogenase [Sulfolobus solfataricus]
Length = 347
Score = 141 bits (353), Expect = 9e-33
Identities = 98/316 (31%), Positives = 156/316 (49%), Gaps = 18/316 (5%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRI------KPPQIMGHEVAGE 72
L E+ VPKP +VLIKV A +C +D+H+ + + RI K P +GHE+AG+
Sbjct: 15 LQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQ-GRFGNLRIVEDLGVKLPVTLGHEIAGK 73
Query: 73 VVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVP 132
+ EVG V G GD V+V G CY CR G+ H+C + + G++ DG +AEY +VP
Sbjct: 74 IEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGINFDGAYAEYVIVP 133
Query: 133 AQNVWKNPKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITGA-GPLGLLGIAVA 187
+ + A G AV P K++L+ GA G LG + + +A
Sbjct: 134 HYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPT--KTLLVVGAGGGLGTMAVQIA 191
Query: 188 KASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAP 247
KA +I + + E AK+ GADYVIN +D + E+ IT+ GVD ++ + +
Sbjct: 192 KAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNSE 251
Query: 248 KALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLL 307
K L +A+ G+ ++GL+ + + + + V + G + + RL
Sbjct: 252 KTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQ--SDFLGIMRLA 309
Query: 308 QSGKLNLDPIITHKYK 323
++GK+ P+IT K
Sbjct: 310 EAGKVK--PMITKTMK 323
>gb|AAK42584.1| Alcohol dehydrogenase (Zn containing) (adh-7) [Sulfolobus
solfataricus]
Length = 328
Score = 141 bits (351), Expect = 2e-32
Identities = 99/323 (30%), Positives = 167/323 (51%), Gaps = 19/323 (5%)
Query: 7 AIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMG 66
AI+K +G EL DV +P G +++KV+AT +C DLH+ + + +++ P+I+G
Sbjct: 4 AILKN---FGEELSLEDVREPSNG-IVLKVLATGLCHGDLHVINGDWRYEIKVELPKILG 59
Query: 67 HEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFA 126
HE+ GEVV+ G + GD V V I CGKC C +Y C+ KI G++ +G FA
Sbjct: 60 HEIVGEVVK---GNGTFKEGDKVLVYNSIGCGKCKYCASKKYQYCEKVKIIGLNINGGFA 116
Query: 127 EYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGIAV 186
EY VP+ N+ P + A L + G + G + SVLI G G + LL + +
Sbjct: 117 EYVSVPSDNILLRVDGEPVKLAPLAD-AGITAYSSAKGITNEDSVLIIGTGAVALLALQI 175
Query: 187 AKASGAYPVIVSEPSDFRRELAKKVGADYVIN-PFEEDVVKEVMDITDGNGVDVFLEFSG 245
K GA ++ + + E AK++GAD VIN ++ + EV + + D +++ G
Sbjct: 176 LKLKGARVTVIGHNKN-KLEKAKELGADEVINIKYDSTIASEVKE----SKFDYIIDYVG 230
Query: 246 APKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSR 305
+ L + + G + ++G + G +++ L++ K L V GI ++ +V +
Sbjct: 231 SDYTLSDSMWLLNREGELRIIGEFGGTITVP-EQLLVLKGLKVRGIL-YGSFDDLISVYK 288
Query: 306 LLQSGKLNLDPII-THKYKGFDK 327
L GK+ PI+ T+K + +K
Sbjct: 289 LYNEGKIR--PIVNTYKLRDINK 309
>sp|P80094|FADH_AMYME NAD/MYCOTHIOL-DEPENDENT FORMALDEHYDE DEHYDROGENASE (MD-FALDH)
Length = 360
Score = 140 bits (350), Expect = 2e-32
Identities = 111/351 (31%), Positives = 163/351 (45%), Gaps = 44/351 (12%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
EL ++ +P PGP EV + ++C TDL E + P ++GHE AG V VG
Sbjct: 17 ELTDIVIPDPGPSEVTALIATCAVCHTDLTYREGG----INDEFPFLLGHEAAGTVESVG 72
Query: 78 PGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNT-----KIFGVDTD--------GV 124
GV+ ++ GDYV + VCG+C AC+RG+ C +T K+ D G
Sbjct: 73 EGVDSVQPGDYVVLNWRAVCGQCRACKRGRPQYCFSTFNATQKMTLTDGTELTPALGIGA 132
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPIS-GKSVLITGAGP 178
FA+ +V A K + P A L LG AV+T G +S G SV + G G
Sbjct: 133 FADKTLVHAGQCTKVDPAADPAVAGLLGCGVMAGLGAAVNT---GAVSRGDSVAVIGCGA 189
Query: 179 LGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVD 238
+G IA A+ +GA +I + + E A ++GA + +N E DVV+ V +T G G D
Sbjct: 190 VGDAVIAGARLAGANKIIAVDRDAKKLEWATELGATHTVNATETDVVEAVQALTGGFGAD 249
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWE 298
V ++ G P+ +Q A AG V L+G+ + ++ L F G L
Sbjct: 250 VVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLEMPLLDFFS-------RGGALKS 302
Query: 299 TWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
+WY + L G+L LD +T + D E+AF M AG+
Sbjct: 303 SWYGDCLPERDFPVLIDLHLQGRLPLDKFVTERI-SLDDVEKAFHTMHAGE 352
>pir||T36783 probable zinc-binding alcohol dehydrogenase - Streptomyces
coelicolor >gi|5441756|emb|CAB46780.1| (AL096811)
putative zinc-binding alcohol dehydrogenase
[Streptomyces coelicolor A3(2)]
Length = 358
Score = 140 bits (350), Expect = 2e-32
Identities = 95/279 (34%), Positives = 137/279 (49%), Gaps = 13/279 (4%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG- 77
+ +V V PGPGE L+ V +CG+DLH + ++ P ++GHEV G VV G
Sbjct: 25 VTDVPVRPPGPGEALVAVRYGGVCGSDLHYWRHGGVGDFHLREPMLLGHEVVGTVVAYGS 84
Query: 78 PGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFG-----VDTDGVFAEYAVVP 132
P G G V+V CG C C + +VC++T+ G G FA VVP
Sbjct: 85 PDTPGPAAGTSVAVHPATPCGVCPECVDRRRNVCRDTRYLGSAARFPHVQGGFAARIVVP 144
Query: 133 AQNVWKNPKSIPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASG 191
A + P + P A L EPL A+ V AG +G+ VL+TGAGP+G L +A AKA+G
Sbjct: 145 AGQLRPLPAGLDPRRAALAEPLSVALHAVRRAGDPAGRHVLVTGAGPIGCLVVAAAKAAG 204
Query: 192 AYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALE 251
A V V++ E A+ GAD ++ + D ++ VD +E SG L+
Sbjct: 205 AAHVTVTDLLPAALEYARAAGADTLVRADDPDDAGWPVE------VDTAVEASGVAAGLD 258
Query: 252 QGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYG 290
L+ V G V LG+ P S NL++ + + + G
Sbjct: 259 TCLRLVRRGGVVVQLGMLPPGQSPFAGNLLVSREIELRG 297
>sp|Q02912|DHSO_BOMMO SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)
>gi|422395|pir||S32484 L-iditol 2-dehydrogenase (EC
1.1.1.14) - silkworm >gi|217260|dbj|BAA02634.1| (D13371)
mammalian sorbitol dehydrogenase homolog [Bombyx mori]
>gi|1871449|dbj|BAA11030.1| (D66906) sorbitol
dehydrogenase [Bombyx mori]
Length = 348
Score = 140 bits (349), Expect = 3e-32
Identities = 99/350 (28%), Positives = 171/350 (48%), Gaps = 13/350 (3%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
M+E A++ A + ++ VP+ EVLIK+ ICG+D+ +Y I
Sbjct: 1 MTENYAAVLHG--ANDVRIEKIPVPEINDDEVLIKIDCVGICGSDVKLYSTGTCGADVID 58
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTK-IFGV 119
P ++GHE AG VV+VG V + VGD V++E C C C+RG+Y++C + +
Sbjct: 59 KPIVIGHEGAGTVVKVGDKVSSLRVGDRVAIEPTQPCRSCELCKRGKYNLCVEPRYCSSM 118
Query: 120 DTDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGP 178
G Y A K P ++ E +PL + I+ G ++I GAGP
Sbjct: 119 GAPGNLCRYYKHVADFCHKLPDNLTMEEGAAVQPLAIVIHACNRAKITLGSKIVILGAGP 178
Query: 179 LGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI----NPFEEDVVKEVMDITDG 234
+G+L AKA GA +I+++ R + A ++GAD V+ +E+VV++++ + G
Sbjct: 179 IGILCAMSAKAMGASKIILTDVVQSRLDAALELGADNVLLVRREYTDEEVVEKIVKLL-G 237
Query: 235 NGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGR 294
+ DV ++ G A L AG V ++G+ V + + ++ + + V G
Sbjct: 238 DRPDVSIDACGYGSAQRVALLVTKTAGLVLVVGIADKTVELPLSQALL-REVDVVG--SF 294
Query: 295 HLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+ T+ + SG + LD ITH++ +K +EA +L ++G K++
Sbjct: 295 RIMNTYQPALAAVSSGAIPLDKFITHRFP-LNKTKEALDLAKSGAAMKIL 343
>sp|P42327|ADH2_BACST ALCOHOL DEHYDROGENASE (ADH) >gi|1075811|pir||S47643 alcohol
dehydrogenase (EC 1.1.1.1) - Bacillus stearothermophilus
(strain DSM 2334) >gi|580823|emb|CAA80989.1| (Z25544)
alcohol dehydrogenase [Bacillus stearothermophilus]
Length = 339
Score = 139 bits (348), Expect = 3e-32
Identities = 121/343 (35%), Positives = 171/343 (49%), Gaps = 31/343 (9%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVE 75
E+ EV+ PK GEVL+K+ A +C TDLH +W IKP P I GHE G VVE
Sbjct: 14 EIKEVERPKLEEGEVLVKIEACGVCHTDLHAAH-GDWP---IKPKLPLIPGHEGVGIVVE 69
Query: 76 VGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQ 134
V GV+ I+VGD V + + CG+C C GQ +C + G DG +AEY PA
Sbjct: 70 VAKGVKSIKVGDRVGIPWLYSACGECEYCLTGQETLCPHQLNGGYSVDGGYAEYCKAPAD 129
Query: 135 NVWKNPKSIPP-EYATLQEPLGNAVDTVLAGPIS----GKSVLITGAGPLGLLGIAVAKA 189
V K P ++ P E A + L V T A +S G+ V I G G LG + + AKA
Sbjct: 130 YVAKIPDNLDPVEVAPI---LCAGVTTYKALKVSGARPGEWVAIYGIGGLGHIALQYAKA 186
Query: 190 SGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKA 249
G V+ + SD + +LAK +GAD IN +ED VK + D GV + + KA
Sbjct: 187 MG-LNVVAVDISDEKSKLAKDLGADIAINGLKEDPVKAIHD--QVGGVHAAISVAVNKKA 243
Query: 250 LEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGI---TGRHLWETWYTVSRL 306
EQ Q+V G + ++GL + I + ++ ++V G T + + E +R
Sbjct: 244 FEQAYQSVKRGGTLVVVGLPNADLPIPIFDTVL-NGVSVKGSIVGTRKDMQEALDFAAR- 301
Query: 307 LQSGKLNLDPIITHKYKGFDKYEEAFELMRAGK-TGKVVFMLK 348
GK+ PI+ + ++ E FE M GK G++V LK
Sbjct: 302 ---GKVR--PIV--ETAELEEINEVFERMEKGKINGRIVLKLK 337
>gb|AAC32671.1| (U61983) benzyl alcohol dehydrogenase [Acinetobacter calcoaceticus]
Length = 371
Score = 139 bits (348), Expect = 3e-32
Identities = 114/365 (31%), Positives = 177/365 (48%), Gaps = 45/365 (12%)
Query: 1 MSEKMVAIMKTKPAYGA--ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSR 58
MSE I P GA EL + + +P EVL+KV+AT +C TDL + +
Sbjct: 1 MSELKDIIAAVTPCKGADFELQALKIRQPQGDEVLVKVVATGMCHTDLIVRD----QYYP 56
Query: 59 IKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TK 115
+ P ++GHE +G + +GP V ++VGD+V V ++ CGKC C G C
Sbjct: 57 VPLPAVLGHEGSGIIEAIGPNVTELQVGDHV-VLSYGYCGKCTQCNTGNPAYCSEFFGRN 115
Query: 116 IFGVDTDG--------------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLG 155
G D++G FA YA+ N K K +P E L PLG
Sbjct: 116 FSGADSEGNHALCTHDQGVVNDHFFAQSSFATYALSRENNTVKVTKDVPIE---LLGPLG 172
Query: 156 NAVDT-----VLAGPISGKSVLIT-GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAK 209
+ T + A ++ S L+T GAG +GL + AK GA +I + + R ELAK
Sbjct: 173 CGIQTGAGACINALKVTPASSLVTWGAGAVGLSALLAAKVCGASIIIAVDIVESRLELAK 232
Query: 210 KVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLY 269
++GA +VIN +D V + +ITDG GV+ LE +G P+ L+QG+ A+ G+++++G
Sbjct: 233 QLGATHVINSKTQDPVAAIKEITDG-GVNFALESTGRPEILKQGVDALGILGKIAVVGAP 291
Query: 270 PGKVSIDFN-NLIIFKALTVYGITGRHLWETWY--TVSRLLQSGKLNLDPIITHKYKGFD 326
+ F+ N ++ T+ G+ + + RL Q GK D ++ K+ FD
Sbjct: 292 QLGTTAQFDVNDLLLGGKTILGVVEGSGSPKKFIPELVRLYQQGKFPFDQLV--KFYAFD 349
Query: 327 KYEEA 331
+ +A
Sbjct: 350 EINQA 354
>dbj|BAB10455.1| (AB005234) alcohol dehydrogenase-like protein [Arabidopsis
thaliana]
Length = 383
Score = 139 bits (348), Expect = 3e-32
Identities = 107/355 (30%), Positives = 167/355 (46%), Gaps = 45/355 (12%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPG- 79
E +P+P E+LIK A +C +DLH+ + + P ++GHE+ GEVVE GP
Sbjct: 28 EFHIPRPKSNEILIKTKACGVCHSDLHVMK----GEIPFASPCVIGHEITGEVVEHGPLT 83
Query: 80 ----VEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---------------TKIFGVD 120
+ +G V + CG C C +G +C++ T++F
Sbjct: 84 DHKIINRFPIGSRVVGAFIMPCGTCSYCAKGHDDLCEDFFAYNRAKGTLYDGETRLFLRH 143
Query: 121 TD--------GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS----- 167
D G AEY V PA + P+S+P + + LG AV T
Sbjct: 144 DDSPVYMYSMGGMAEYCVTPAHGLAPLPESLPYSESAI---LGCAVFTAYGAMAHAAEIR 200
Query: 168 -GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVK 226
G S+ + G G +G + +A+A GA +I + D + + AK +GA +++N +ED V+
Sbjct: 201 PGDSIAVIGIGGVGSSCLQIARAFGASDIIAVDVQDDKLQKAKTLGATHIVNAAKEDAVE 260
Query: 227 EVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGL-YPGKV-SIDFNNLIIFK 284
+ +IT G GVDV +E G P+ Q +V G+ ++GL G V ID N L+ K
Sbjct: 261 RIREITGGMGVDVAVEALGKPQTFMQCTLSVKDGGKAVMIGLSQAGSVGEIDINRLVRRK 320
Query: 285 ALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
+ V G G + V +L +SG NL ++ KYK F+ +AF+ + GK
Sbjct: 321 -IKVIGSYGGRARQDLPKVVKLAESGIFNLTNAVSSKYK-FEDAGKAFQDLNEGK 373
>gb|AAG10028.1|AF282240_12 (AF282240) alcohol dehydrogenase [Acinetobacter sp. SE19]
Length = 352
Score = 139 bits (346), Expect = 6e-32
Identities = 91/285 (31%), Positives = 139/285 (47%), Gaps = 14/285 (4%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWN---------EWAQSRIKPPQIMGHE 68
E VE ++P+P EVL+ V A +C TDLH++E A +KPP + HE
Sbjct: 14 EDVEKEIPQPKGTEVLLHVKAAGLCHTDLHLWEGYYDLGGGKRLSLADRGLKPPLTLSHE 73
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEY 128
+ G+VV VGP E ++VG V I CG+C C+RG+ ++C + G+ G FAEY
Sbjct: 74 ITGQVVAVGPDAESVKVGMVSLVHPWIGCGECNYCKRGEENLCAKPQQLGIAKPGGFAEY 133
Query: 129 AVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL---AGPISGKSVLITGAGPLGLLGIA 185
+VP + + A G + L I + V+I GAG LGL+ +
Sbjct: 134 IIVPHPRYLVDIAGLDLAEAAPLACAGVTTYSALKKFGDLIQSEPVVIIGAGGLGLMALE 193
Query: 186 VAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSG 245
+ KA A IV + D + E A+ GA VIN ED ++++ TDG G + L+ G
Sbjct: 194 LLKAMQAKGAIVVDIDDSKLEAARAAGALSVINSRSEDAAQQLIQATDG-GARLILDLVG 252
Query: 246 APKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYG 290
+ L L + G + + GL G++ + +I + LT+ G
Sbjct: 253 SNPTLSLALASAARGGHIVICGLMGGEIKLSI-PVIPMRPLTIQG 296
>pir||C81088 alcohol dehydrogenase, zinc-containing NMB1395 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226634|gb|AAF41759.1| (AE002488) alcohol
dehydrogenase, zinc-containing [Neisseria meningitidis
MC58]
Length = 346
Score = 138 bits (345), Expect = 8e-32
Identities = 98/346 (28%), Positives = 164/346 (47%), Gaps = 17/346 (4%)
Query: 9 MKTKPAYGAELVEVDV-PKP---GPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
MK +GA + + P+P P + ++K++ T+ICGTDL I++ + +I
Sbjct: 1 MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKN---PEVADGRI 57
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTK-IFGVDTDG 123
+GHE G V EVG V+ I+VGD V + C C C+ Y C+N I G DG
Sbjct: 58 LGHEGIGIVEEVGEAVKNIKVGDKVIISCVSKCCTCDNCKTQLYSHCRNGGWILGYMIDG 117
Query: 124 VFAEYAVVPA--QNVWKNPKSIPPEYATLQE---PLGNAVDTVLAGPISGKSVLITGAGP 178
AEY P ++ P ++ E A L P + + G +V I GAGP
Sbjct: 118 TQAEYVRTPYADNSLVPLPDNVNEEIALLLSDALPTAHEIGVQYGDVKPGDTVFIAGAGP 177
Query: 179 LGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVD 238
+G+ + A+ +IV + + R +LAK++GA + INP +V K+V I +GVD
Sbjct: 178 VGMSALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTINPASGEVSKQVFAIVGEDGVD 237
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWE 298
+E G P V P G ++++G++ V L I K G+ + E
Sbjct: 238 CAIEAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKKLAITTGLVNANTTE 297
Query: 299 TWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+ + + S ++ ++TH +K F + E+A+++ + +V+
Sbjct: 298 ---MLMKAISSSSVDYTKMLTHHFK-FSELEKAYDVFKHAAENQVM 339
>gi|6322619 sorbitol-induced sorbitol dehydrogenase; Sor1p [Saccharomyces
cerevisiae] >gi|544159|sp|P35497|DHSO_YEAST SORBITOL
DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE)
>gi|1078385|pir||S55941 L-iditol 2-dehydrogenase (EC
1.1.1.14) SOR1 - yeast (Saccharomyces cerevisiae)
>gi|295661|gb|AAA35027.1| (L11039) sorbitol
dehydrogenase [Saccharomyces cerevisiae]
>gi|1015919|emb|CAA89692.1| (Z49659) ORF YJR159w
[Saccharomyces cerevisiae]
Length = 357
Score = 138 bits (344), Expect = 1e-31
Identities = 97/314 (30%), Positives = 157/314 (49%), Gaps = 13/314 (4%)
Query: 29 PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDY 88
P V + + AT ICG+D+H Y + +K P ++GHE +G+VVEVG V ++VGD
Sbjct: 30 PHYVKLAIKATGICGSDIHYYRSGGIGKYILKAPMVLGHESSGQVVEVGDAVTRVKVGDR 89
Query: 89 VSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVWKNPKSIPPEY 147
V++E + + G+Y++C + DG +Y + P + K P+ + E
Sbjct: 90 VAIEPGVPSRYSDETKEGRYNLCPHMAFAATPPIDGTLVKYYLSPEDFLVKLPEGVSYEE 149
Query: 148 ATLQEPLGNAV-DTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRE 206
EPL V LAG G V++ GAGP+GLL AVA+A GA VI + D + +
Sbjct: 150 GACVEPLSVGVHSNKLAGVRFGTKVVVFGAGPVGLLTGAVARAFGATDVIFVDVFDNKLQ 209
Query: 207 LAKKVGADYVINPFE------EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA 260
AK GA N + +D+ V + GN DV E SGA ++ ++
Sbjct: 210 RAKDFGATNTFNSSQFSTDKAQDLADGVQKLLGGNHADVVFECSGADVCIDAAVKTTKVG 269
Query: 261 GRVSLLGLYPGKVSIDFNNL-IIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIIT 319
G + +G+ GK +F + K + + G R+ + + L+ +GK+N+ P+IT
Sbjct: 270 GTMVQVGM--GKNYTNFPIAEVSGKEMKLIGCF-RYSFGDYRDAVNLVATGKVNVKPLIT 326
Query: 320 HKYKGFDKYEEAFE 333
HK+K F+ +A++
Sbjct: 327 HKFK-FEDAAKAYD 339
>gi|6319955 Ydl246cp [Saccharomyces cerevisiae] >gi|2117435|pir||S67811
L-iditol 2-dehydrogenase (EC 1.1.1.14) YDL246c - yeast
(Saccharomyces cerevisiae) >gi|1431420|emb|CAA98826.1|
(Z74294) ORF YDL246c [Saccharomyces cerevisiae]
Length = 357
Score = 138 bits (343), Expect = 1e-31
Identities = 97/314 (30%), Positives = 156/314 (48%), Gaps = 13/314 (4%)
Query: 29 PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDY 88
P V + + AT ICG+D+H Y + +K P ++GHE +G+VVEVG V ++VGD
Sbjct: 30 PHYVKLAIKATGICGSDIHYYRSGGIGKYILKAPMVLGHESSGQVVEVGDAVTRVKVGDR 89
Query: 89 VSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVWKNPKSIPPEY 147
V++E + + G Y++C + DG +Y + P + K P+ + E
Sbjct: 90 VAIEPGVPSRYSDETKEGSYNLCPHMAFAATPPIDGTLVKYYLSPEDFLVKLPEGVSYEE 149
Query: 148 ATLQEPLGNAV-DTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRE 206
EPL V LAG G V++ GAGP+GLL AVA+A GA VI + D + +
Sbjct: 150 GACVEPLSVGVHSNKLAGVRFGTKVVVFGAGPVGLLTGAVARAFGATDVIFVDVFDNKLQ 209
Query: 207 LAKKVGADYVINPFE------EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA 260
AK GA N + +D+ V + GN DV E SGA ++ ++
Sbjct: 210 RAKDFGATNTFNSSQFSTDKAQDLADGVQKLLGGNHADVVFECSGADVCIDAAVKTTKVG 269
Query: 261 GRVSLLGLYPGKVSIDFNNL-IIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIIT 319
G + +G+ GK +F + K + + G R+ + + L+ +GK+N+ P+IT
Sbjct: 270 GTMVQVGM--GKNYTNFPIAEVSGKEMKLIGCF-RYSFGDYRDAVNLVATGKVNVKPLIT 326
Query: 320 HKYKGFDKYEEAFE 333
HK+K F+ +A++
Sbjct: 327 HKFK-FEDAAKAYD 339
>dbj|BAA75343.1| (AB011837) sorbitol dehydrogenase [Bacillus halodurans]
Length = 306
Score = 137 bits (341), Expect = 2e-31
Identities = 92/289 (31%), Positives = 137/289 (46%), Gaps = 11/289 (3%)
Query: 9 MKTKPAYGAELVEVD-VPKPG---PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
MK YG + + + P P +++IKV A ICG+DL Y+ P
Sbjct: 1 MKALNLYGIQDLRFEETPAPSIEHDDDIIIKVKAVGICGSDLSRYK----KLGPYVPGMT 56
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
GHE AGEVV++G V G +GD V+ CG+C C+ G+ C+ + G G
Sbjct: 57 FGHEFAGEVVKIGRSVTGFSIGDRVAACPTYTCGQCRYCQLGEPTRCERLSVIGARHPGA 116
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLG 183
+AEY +PA++V P + + A L EP I G SV I G G +GLL
Sbjct: 117 YAEYVKLPAKHVIPLPNVVNYDEAALIEPASVVAHGFYRTNIKPGASVAIMGVGSIGLLA 176
Query: 184 IAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEF 243
+ AK GA V + + + +A ++GAD +I+ + K++++ T+G GVDV +E
Sbjct: 177 VQWAKIFGATTVFAIDIDEQKLNVANQLGADVLISSLQRPAHKQILEYTNGIGVDVAVES 236
Query: 244 SGAPKALEQGLQAVTPAGRVSLLGLYPGKVSID--FNNLIIFKALTVYG 290
+G P Q G V LG+ V I+ + I+ L VYG
Sbjct: 237 AGTPSTSAQVFALPKKGGEVVFLGIPYADVQIERFYFEKIVRNELHVYG 285
>pir||C72533 probable alcohol dehydrogenase APE2239 - Aeropyrum pernix (strain
K1) >gi|5105939|dbj|BAA81251.1| (AP000063) 359aa long
hypothetical alcohol dehydrogenase [Aeropyrum pernix]
Length = 359
Score = 137 bits (341), Expect = 2e-31
Identities = 100/337 (29%), Positives = 171/337 (50%), Gaps = 21/337 (6%)
Query: 21 EVDVPK-PGPGEVLIKVIATSICGTDLHIYE--WNEWAQSRIKPPQIMGHEVAGEVVEVG 77
+VD P+ G +V++++ +C TDLH+ + W+E Q ++ P +GHE G + EV
Sbjct: 32 DVDYPRLEGRFDVIVRIAGAGVCHTDLHLVQGMWHELLQPKL--PYTLGHENVGYIEEVA 89
Query: 78 PGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVW 137
GVEG+E GD V + + G C ACR G+ C+N + G++ DG FAE+ ++V
Sbjct: 90 EGVEGLEKGDPVILHPAVTDGTCLACRAGEDMHCENLEFPGLNIDGGFAEFMRTSHRSVI 149
Query: 138 KNPKSIPPEYATLQEPLGN-------AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKAS 190
K PK I E PL + AV G V I G G LG + + + K
Sbjct: 150 KLPKDISREKLVEMAPLADAGITAYRAVKKAARTLYPGAYVAIVGVGGLGHIAVQLLKVM 209
Query: 191 GAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKAL 250
VI + + + +LA+++GAD+V++ D VK+VM++T G GV+V ++F G+ +
Sbjct: 210 TPATVIALDVKEEKLKLAERLGADHVVDA-RRDPVKQVMELTRGRGVNVAMDFVGSQATV 268
Query: 251 EQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSG 310
+ + GR+ ++G Y G++ +I + + G ++ E V+ LQ G
Sbjct: 269 DYTPYLLGRMGRLIIVG-YGGELRFPTIRVISSEVSFEGSLVGNYV-ELHELVTLALQ-G 325
Query: 311 KLNLDPIITHKYKGFDKYEEAFELMRAGKT-GKVVFM 346
K+ ++ + HK D+ + E + G+ G+ V +
Sbjct: 326 KVRVE-VDIHK---LDEINDVLERLEKGEVLGRAVLI 358
>gi|6323099 Ylr070cp [Saccharomyces cerevisiae] >gi|2117438|pir||S64902
probable sugar reductase (EC 1.1.1.-) YLR070c - yeast
(Saccharomyces cerevisiae) >gi|1360424|emb|CAA97627.1|
(Z73242) ORF YLR070c [Saccharomyces cerevisiae]
Length = 356
Score = 136 bits (340), Expect = 3e-31
Identities = 102/323 (31%), Positives = 154/323 (47%), Gaps = 12/323 (3%)
Query: 19 LVEVDVPK-PGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
L V +PK P EV+I++ AT ICG+D+H Y A ++ P ++GHE +G V +G
Sbjct: 20 LTNVSIPKISDPNEVIIQIKATGICGSDIHYYTHGRIANYVVESPMVLGHESSGIVALIG 79
Query: 78 PGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT-DGVFAEYAVVPAQNV 136
V+ ++VGD V++E I + G+Y++ N K DG +Y V
Sbjct: 80 ENVKTLKVGDRVALEPGIPDRFSPEMKEGRYNLDPNLKFAATPPFDGTLTKYYKTMKDFV 139
Query: 137 WKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPV 195
+K P + E L EPL A+ I G ++ GAGP+GLL VA GA V
Sbjct: 140 YKLPDDVSFEEGALIEPLSVAIHANKLAKIKFGARCVVFGAGPIGLLAGKVASVFGAADV 199
Query: 196 IVSEPSDFRRELAKKVGADYVIN----PFEEDVVKEVMDITDGNGVDVFLEFSGAPKALE 251
+ + + + E A++ GA +++N P V + G DV E SGA +
Sbjct: 200 VFVDLLENKLETARQFGATHIVNSGDLPHGVTVDSVIKKAIGKKGADVVFECSGAEPCVR 259
Query: 252 QGLQAVTPAGRVSLLGLYPGKVSIDFN-NLIIFKALTVYGITGRHLWETWYTVSRLLQSG 310
G++ G + +G+ G+ I F ++I K LT G R+ + L+ S
Sbjct: 260 AGIEVCKAGGTIVQVGM--GQEEIQFPISIIPTKELTFQGCF-RYCQGDYSDSIELVSSR 316
Query: 311 KLNLDPIITHKYKGFDKYEEAFE 333
KL+L P ITH+Y F EAFE
Sbjct: 317 KLSLKPFITHRY-SFKDAVEAFE 338
>sp|P25406|ADHB_UROHA ALCOHOL DEHYDROGENASE I-B (ADH IB) >gi|2134226|pir||S62639 alcohol
dehydrogenase (EC 1.1.1.1) I chain B - Indian
spiny-tailed lizard
Length = 375
Score = 136 bits (338), Expect = 5e-31
Identities = 110/374 (29%), Positives = 173/374 (45%), Gaps = 42/374 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + +P +VE++V P EV IK++A+ IC +D H+ ++ P
Sbjct: 8 KCKAAVVWEPKKPFSIVEIEVAPPKAHEVRIKILASGICRSDDHVLS----GALKVNFPI 63
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC------------ 111
I+GHE AG V VG GV ++ GD V CG+C +CR + +VC
Sbjct: 64 ILGHEAAGVVESVGEGVTSMKPGDKVIPIFLPQCGECNSCRHPRGNVCKKSELGPFTGLL 123
Query: 112 ---------QNTKIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNA 157
Q ++ G F EY V P +V K S P E L G A
Sbjct: 124 YDGTSRFTYQGKPVYHFVRTGTFTEYTVAPEDSVVKIDASAPLEKVCLIGCGFSTGYGAA 183
Query: 158 VDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI 217
+++ P G + + G G +GL + KA+GA +I + + + AK++GA +
Sbjct: 184 INSAKVQP--GSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINKEKFPKAKELGATECV 241
Query: 218 NP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVS 274
NP +++ + + + D+TDG GV+ E G + L + G ++G+ P
Sbjct: 242 NPLDYKKPINEVLFDMTDGEGVEYSFEVIGRTDTMTAALASCHNNYGTSVIVGVPPSASQ 301
Query: 275 IDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
I F+ L++F T G + G W++ V RL+ K LDP+ITH F+K E
Sbjct: 302 IAFDPLLLFTGRTWKGSVFGG--WKSKDAVPRLVSDFMGKKFILDPLITHTMP-FEKINE 358
Query: 331 AFELMRAGKTGKVV 344
FEL+R+GK+ + V
Sbjct: 359 GFELLRSGKSIRTV 372
>sp|P36624|DHSO_SCHPO PUTATIVE SORBITOL DEHYDROGENASE (L-IDITOL 2-DEHYDROGENASE) (TMS1
PROTEIN) >gi|422054|pir||S35981 L-iditol 2-dehydrogenase
(EC 1.1.1.14) - fission yeast (Schizosaccharomyces
pombe) >gi|542212|pir||S38345 dehydrogenase - fission
yeast (Schizosaccharomyces pombe)
>gi|396479|emb|CAA52443.1| (X74422) dehydrogenase
[Schizosaccharomyces pombe]
Length = 347
Score = 135 bits (337), Expect = 7e-31
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 20/325 (6%)
Query: 31 EVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVS 90
+V + + AT ICG+D+H ++ +K P I+GHE AG VVEVG GV ++ GD V+
Sbjct: 18 QVKVAIKATGICGSDVHYWKEGGIGDFILKKPMILGHESAGVVVEVGKGVSSLKPGDPVA 77
Query: 91 VETHIVCGKCYACRRGQYHVCQNTKIFGVDT-DGVFAEYAVVPAQNVWKNPKSIPPEYAT 149
VE VC C CR G+Y++C + + DG Y + K PK I E
Sbjct: 78 VEPGCVCRLCDYCRSGRYNLCPHMEFAATPPYDGTLRTYYITTEDFCTKLPKQISVEEGA 137
Query: 150 LQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELA 208
L EP+ AV + G + G VL+ G G +GLL +AVAKA GA ++ + S R E A
Sbjct: 138 LFEPMSVAVHAMTRGNLKCGSRVLVMGCGTVGLLMMAVAKAYGAIDIVAVDASPSRVEFA 197
Query: 209 KK-VGADYVINPFEEDVVKEVMDITDGNG------VDVFLEFSGAPKALEQGLQAVTPAG 261
+K VGA PF KE + D ++ + EF A A G+ T
Sbjct: 198 QKYVGA----KPFTPIAAKENESLPDYAQRYKQAIIEKYGEFDFAVDATGVGICIHTAVL 253
Query: 262 RVSLLGLY----PGKVSIDFN-NLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
+ G + GK IDF N II + V G + R+ + L+ +G +++ P
Sbjct: 254 ALKRGGTFVQAGNGKPVIDFPINHIINYEINVLG-SFRYAHGCYKQSLFLVSNGLVDVKP 312
Query: 317 IITHKYKGFDKYEEAFELMRAGKTG 341
+ITH++ F +A+E + +G+ G
Sbjct: 313 LITHRF-AFKDALKAYETVASGEEG 336
>sp|O31186|ADHA_RHIME ALCOHOL DEHYDROGENASE >gi|2645697|gb|AAB87463.1| (AF031940) alcohol
dehydrogenase [Sinorhizobium meliloti]
Length = 340
Score = 135 bits (337), Expect = 7e-31
Identities = 101/284 (35%), Positives = 148/284 (51%), Gaps = 17/284 (5%)
Query: 15 YGAELV--EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGE 72
+G LV EV VP+PGPG+VLIK AT +C TDLH + +W R PP I GHE G
Sbjct: 11 FGKPLVIEEVPVPQPGPGQVLIKYEATGVCHTDLHAAK-GDWPV-RPNPPFIPGHEGVGY 68
Query: 73 VVEVGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVV 131
V ++G V ++ GD V V H CG C CR G +C + + G DG FA+Y +
Sbjct: 69 VAKLGAEVTRLKEGDRVGVPWLHTACGCCTPCRTGWETLCGSQQNTGYSVDGTFAQYGLA 128
Query: 132 PAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS-----GKSVLITGAGPLGLLGIAV 186
V + P + E+ L V TV G G+ VL++G G LG + +
Sbjct: 129 DPDFVGRLPARL--EFGPAAPVLCAGV-TVYKGLKETEVRPGEWVLVSGIGGLGHMAVQY 185
Query: 187 AKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGA 246
AKA G + V ++ + LA+K+GAD V++ D V+EV T G+ L + +
Sbjct: 186 AKAMGMH-VAAADIFPDKLALAEKLGADLVVDARAPDAVEEVQRRT--GGLHGALVTAVS 242
Query: 247 PKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYG 290
PKA+EQ + G ++L+GL PG++ + + ++ K +TV G
Sbjct: 243 PKAMEQAYSMLRSKGTMALVGLPPGQICLPVFDTVL-KRITVRG 285
>pir||T39670 probable sorbitol dehydrogenase - fission yeast
(Schizosaccharomyces pombe) >gi|3850083|emb|CAA21910.1|
(AL033389) putative sorbitol dehydrogenase
[Schizosaccharomyces pombe]
Length = 360
Score = 135 bits (337), Expect = 7e-31
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 20/325 (6%)
Query: 31 EVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVS 90
+V + + AT ICG+D+H ++ +K P I+GHE AG VVEVG GV ++ GD V+
Sbjct: 31 QVKVAIKATGICGSDVHYWKEGGIGDFILKKPMILGHESAGVVVEVGKGVSSLKPGDPVA 90
Query: 91 VETHIVCGKCYACRRGQYHVCQNTKIFGVDT-DGVFAEYAVVPAQNVWKNPKSIPPEYAT 149
VE VC C CR G+Y++C + + DG Y + K PK I E
Sbjct: 91 VEPGCVCRLCDYCRSGRYNLCPHMEFAATPPYDGTLRTYYITTEDFCTKLPKQISVEEGA 150
Query: 150 LQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELA 208
L EP+ AV + G + G VL+ G G +GLL +AVAKA GA ++ + S R E A
Sbjct: 151 LFEPMSVAVHAMTRGNLKCGSRVLVMGCGTVGLLMMAVAKAYGAIDIVAVDASPSRVEFA 210
Query: 209 KK-VGADYVINPFEEDVVKEVMDITDGNG------VDVFLEFSGAPKALEQGLQAVTPAG 261
+K VGA PF KE + D ++ + EF A A G+ T
Sbjct: 211 QKYVGA----KPFTPIAAKENESLPDYAQRYKQAIIEKYGEFDFAVDATGVGICIHTAVL 266
Query: 262 RVSLLGLY----PGKVSIDFN-NLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
+ G + GK IDF N II + V G + R+ + L+ +G +++ P
Sbjct: 267 ALKRGGTFVQAGNGKPVIDFPINHIINYEINVLG-SFRYAHGCYKQSLFLVSNGLVDVKP 325
Query: 317 IITHKYKGFDKYEEAFELMRAGKTG 341
+ITH++ F +A+E + +G+ G
Sbjct: 326 LITHRF-AFKDALKAYETVASGEEG 349
>pir||G72376 alcohol dehydrogenase, zinc-containing - Thermotoga maritima
(strain MSB8) >gi|4980943|gb|AAD35521.1|AE001722_5
(AE001722) alcohol dehydrogenase, zinc-containing
[Thermotoga maritima]
Length = 368
Score = 134 bits (335), Expect = 1e-30
Identities = 109/364 (29%), Positives = 182/364 (49%), Gaps = 33/364 (9%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
MV +P E D+P+ G +L+++++ +CG+D+H++ + R+ P I
Sbjct: 9 MVLEKFNQPLVYKEFEISDIPR---GSILVEILSAGVCGSDVHMFRGED---PRVPLPII 62
Query: 65 MGHEVAGEVVEVGP-----GVEGIEVGDYVSVETHIVCGKCYACRRGQY-HVCQNTKIFG 118
+GHE AG VVEV E ++ GD + I CG+CY C+ + ++C N K++G
Sbjct: 63 LGHEGAGRVVEVNGEKRDLNGELLKPGDLIVWNRGITCGECYWCKVSKEPYLCPNRKVYG 122
Query: 119 VDTD--------GVFAEYAVV-PAQNVWKNPKSIPPEYATLQEPLG----NAVDTVLAGP 165
++ G ++ + V+ P +V K + + + G +A D
Sbjct: 123 INRGCSEYPHLRGCYSSHIVLDPETDVLKVSEKDDLDVLAMAMCSGATAYHAFDEYPES- 181
Query: 166 ISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE---E 222
+GK+V+I GAGPLGL G+ +A++ GA VIV S R +LA+++GAD +N E E
Sbjct: 182 FAGKTVVIQGAGPLGLFGVVIARSLGAENVIVIAGSPNRLKLAEEIGADLTLNRRETSVE 241
Query: 223 DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFN--NL 280
+ K +MDIT G G D LE +G +AL +G + + G S+ G+ + + F
Sbjct: 242 ERRKAIMDITHGRGADFILEATGDSRALLEGSELLRRGGFYSVAGVAVPQDPVPFKVYEW 301
Query: 281 IIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKT 340
++ K T GI TVS ++ +L L +ITH+ + +A ELM + +
Sbjct: 302 LVLKNATFKGIWVSDTSHFVKTVSITSRNYQL-LSKLITHRLP-LKEANKALELMESREA 359
Query: 341 GKVV 344
KV+
Sbjct: 360 LKVI 363
>gb|AAK41467.1| Alcohol dehydrogenase (Zn containing) (adh-3) [Sulfolobus
solfataricus]
Length = 362
Score = 134 bits (333), Expect = 2e-30
Identities = 111/345 (32%), Positives = 175/345 (50%), Gaps = 27/345 (7%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYE-------WNEWAQSRIKPPQIMGHEVA 70
++ ++DVPK G G+VL+KVI+ IC +D H++ + +W+ ++ P GHEV
Sbjct: 15 KIEDLDVPKVGKGDVLLKVISCGICRSDWHLWRGDPALVAYMQWSGGKL--PITQGHEVY 72
Query: 71 GEVVEVGPGVEGIEVGDYVSVETHIVCGK--CYACRRGQYHVCQNTKIFGVDTDGVFAEY 128
GE+VEVG V + GD V + C C G +VC++ I G +G FAEY
Sbjct: 73 GEIVEVGESVTRLNKGDKVVMPASSTGDNRTCKYCMEGDSNVCEHLVIAGYGINGCFAEY 132
Query: 129 AVVPAQNVW---KNPKSIPPEYATLQE-PLGNAVD--TVLAGPISGKSVLITGAGPLGLL 182
++P ++V K P I E+A L G + + T+ V+I GAG +GL
Sbjct: 133 MLIPERSVIDLVKVPDGIKSEWAALSSCGFGTSWNAFTMKTNLKPSDIVVIIGAGGMGLS 192
Query: 183 GIAVAKASGAYPVIVSEPSDFRRELAKKVGA--DYVINPFEEDVVKEVMDITDGNG-VDV 239
GIA+A A GA VI + ++ E AK +G+ Y + E++ K V DI G VDV
Sbjct: 193 GIAIANALGA-KVIAIDVNERSLEKAKMLGSVETYRHSGKSEELNKIVEDIMKKYGSVDV 251
Query: 240 FLEFSGAPKALEQGLQAVTPAGRVSLLGLY-PGKVSIDFN-NLIIFKALTVYGITGRHLW 297
+ +G P+A+ L + G + L GL GK +L++ + + + G+
Sbjct: 252 IYDTTGIPEAVIPFLPLLKVHGTLLLAGLMMKGKEIFPLPADLVVAREIRIQGVLMLPA- 310
Query: 298 ETWYTVSRLLQSGKLNLDPIITHK---YKGFDKYEEAFELMRAGK 339
+ + T+ +L++ GK+NLDP+I Y D Y+E E AG+
Sbjct: 311 QKFDTIFKLMKEGKINLDPVIYKTISIYDVNDAYKEMSEYKNAGR 355
>pir||S49084 NAD dependent galactitol-1-phosphate dehydrogenase (EC 1.-.-.-) -
Escherichia coli >gi|508176|emb|CAA56231.1| (X79837)
Gat-1-P-DH, NAD dependent [Escherichia coli]
Length = 346
Score = 134 bits (333), Expect = 2e-30
Identities = 101/332 (30%), Positives = 153/332 (45%), Gaps = 29/332 (8%)
Query: 31 EVLIKVIATSICGTDL--------HIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEG 82
EV +K+ ++ +CG+DL H Y P +GHE +G + VG GV+
Sbjct: 27 EVRVKIASSGLCGSDLPRIFKNGAHYY------------PITLGHEFSGYIDAVGSGVDD 74
Query: 83 IEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKS 142
+ GD V+ + C C C +G Y C G DG FAEY VV +NV+ P
Sbjct: 75 LHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTD 134
Query: 143 IPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+P E EP+ + LA K+V+I GAG +GLL I A A GA V + S
Sbjct: 135 MPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDIS 194
Query: 202 DFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAG 261
+ LAK GA N E + + D + LE +G P+ +E ++ P
Sbjct: 195 SEKLALAKSFGAMQTFNSLEMSAPQMQGVLRDVRFNQLILETAGVPQTVELAVEIAGPHA 254
Query: 262 RVSLLGLYPGKVSIDFNNL--IIFKALTVYG--ITGRHLW--ETWYTVSRLLQSGKLNLD 315
+++L+G + + I+ K LTV G + W + W T SRLL KL+L+
Sbjct: 255 QLALVGTLHQDLHLTSTTFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLE 314
Query: 316 PIITHKYKGFDKYEEAF-ELMRAGKTGKVVFM 346
P+I H+ F+ + + ++ R GKV+ +
Sbjct: 315 PLIAHR-GSFESFTQVVRDIARNAMPGKVLLI 345
>sp|P25405|ADHA_UROHA ALCOHOL DEHYDROGENASE I-A (ADH IA) >gi|2134227|pir||S62638 alcohol
dehydrogenase (EC 1.1.1.1) I chain A - Indian
spiny-tailed lizard
Length = 375
Score = 133 bits (331), Expect = 3e-30
Identities = 110/359 (30%), Positives = 169/359 (46%), Gaps = 42/359 (11%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
+++V P EV IK++AT IC +D H+ ++ P ++GHE AG V VG GV
Sbjct: 25 QIEVAPPKAHEVRIKILATGICRSDDHVIS----GAFKMPLPMVLGHEAAGVVESVGEGV 80
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGVDTDGV------------- 124
++ GD V CGKC +CR + ++C + + G+ DG
Sbjct: 81 TCVKPGDKVIPLFVPQCGKCSSCRSTRGNLCTSNDLSAATGLMPDGTSRFTCKGKSLHHF 140
Query: 125 -----FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLIT 174
F EY VV +V K + P E L G AV+T P G + +
Sbjct: 141 ISTSSFTEYTVVHENSVVKIDAAAPLEKVCLIGCGFSTGYGAAVETAKVEP--GSTCAVF 198
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEEDVVKEVMDIT 232
G G +GL + KA+GA +I + + + AK++GA +NP +++ + + + D+T
Sbjct: 199 GLGGVGLSAVMGCKAAGASRIIGVDINKDKFPKAKEMGATECVNPLDYKKPINEVLFDLT 258
Query: 233 DGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYG- 290
G GVD E G + L + G ++GL P I F+ +IF T G
Sbjct: 259 GGEGVDYSFEVIGRTDTMTAALASCHMDYGTSIIVGLPPSASEITFSPGLIFTGRTWKGS 318
Query: 291 ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFM 346
+ G W++ +V RL+ K +LDP+ITH FDK E FEL+RAGK+ + V +
Sbjct: 319 VFGG--WKSKDSVPRLVSDFMQKKFSLDPLITHTMP-FDKINEGFELLRAGKSIRSVLL 374
>gi|6319257 Yal061wp [Saccharomyces cerevisiae] >gi|731294|sp|P39713|YAG1_YEAST
HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE
PROTEIN IN GDH3-CNE1 INTERGENIC REGION
>gi|1077490|pir||S51961 FUN50 protein - yeast
(Saccharomyces cerevisiae) >gi|595525|gb|AAC04973.1|
(U12980) Yal061wp [Saccharomyces cerevisiae]
Length = 417
Score = 132 bits (330), Expect = 4e-30
Identities = 100/317 (31%), Positives = 152/317 (47%), Gaps = 33/317 (10%)
Query: 29 PGEVLIKVIATSICGTDLHIY---------EWNEWAQSRIKPPQIMGHEVAGEVVEVGPG 79
P E++I + ICGTDLH Y + + S PQ MGHE+AG V+EVGPG
Sbjct: 26 PDELVIDIEWCGICGTDLHEYTDGPIFFPEDGHTHEISHNPLPQAMGHEMAGTVLEVGPG 85
Query: 80 VEGIEVGDYVSVETHIVCGK--------------CYACRRGQYHVCQNTKIFGVDTD-GV 124
V+ ++VGD V VE C C AC++G Y++C + G G
Sbjct: 86 VKNLKVGDKVVVEPTGTCRDRYRWPLSPNVDKEWCAACKKGYYNICSYLGLCGAGVQSGG 145
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPI-SGKSVLITGAGPLGLLG 183
FAE V+ + +K P +P + A L +PL + +G + LI GAGP+GL
Sbjct: 146 FAERVVMNESHCYKVPDFVPLDVAALIQPLAVCWHAIRVCEFKAGSTALIIGAGPIGLGT 205
Query: 184 IAVAKASGAYPVIVSEPSDFRRELAKKVGA---DYVINPFEE--DVVKEVMDITDGNGVD 238
I A+G ++VSEP+ RRELA+K+GA D + +E D ++ + D G+G D
Sbjct: 206 ILALNAAGCKDIVVSEPAKVRRELAEKMGARVYDPTAHAAKESIDYLRSIAD--GGDGFD 263
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWE 298
+ SG L +Q +T G L ++ G I F+ + I Y + +
Sbjct: 264 YTFDCSGLEVTLNAAIQCLTFRGTAVNLAMW-GHHKIQFSPMDITLHERKYTGSMCYTHH 322
Query: 299 TWYTVSRLLQSGKLNLD 315
+ V L+ G++++D
Sbjct: 323 DFEAVIEALEEGRIDID 339
>sp|P37190|GATD_ECOLI GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE >gi|7427639|pir||B64976
galactitol-1-phosphate dehydrogenase (EC 1.1.1.-) -
Escherichia coli (strain K-12)
>gi|1736808|dbj|BAA15954.1| (D90847)
Galactitol-1-phosphate dehydrogenase (EC 1.1.1.-).
[Escherichia coli] >gi|1788407|gb|AAC75152.1| (AE000298)
galactitol-1-phosphate dehydrogenase [Escherichia coli
K12]
Length = 346
Score = 132 bits (330), Expect = 4e-30
Identities = 101/332 (30%), Positives = 154/332 (45%), Gaps = 29/332 (8%)
Query: 31 EVLIKVIATSICGTDL--------HIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEG 82
EV +K+ ++ +CG+DL H Y P +GHE +G + VG GV+
Sbjct: 27 EVRVKIASSGLCGSDLPRIFKNGAHYY------------PITLGHEFSGYIDAVGSGVDD 74
Query: 83 IEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKS 142
+ GD V+ + C C C +G Y C G DG FAEY VV +NV+ P
Sbjct: 75 LHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTD 134
Query: 143 IPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+P E EP+ + LA K+V+I GAG +GLL I A A GA V + S
Sbjct: 135 MPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDIS 194
Query: 202 DFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAG 261
+ LAK GA N E + + + + LE +G P+ +E ++ P
Sbjct: 195 SEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVPQTVELAVEIAGPHA 254
Query: 262 RVSLLGLYPGKVSIDFNNL--IIFKALTVYG--ITGRHLW--ETWYTVSRLLQSGKLNLD 315
+++L+G + + I+ K LTV G + W + W T SRLL KL+L+
Sbjct: 255 QLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLE 314
Query: 316 PIITHKYKGFDKYEEAF-ELMRAGKTGKVVFM 346
P+I H+ F+ + +A ++ R GKV+ +
Sbjct: 315 PLIAHR-GSFESFAQAVRDIARNAMPGKVLLI 345
>emb|CAC11970.1| (AL445065) alcohol dehydrogenase related protein [Thermoplasma
acidophilum]
Length = 336
Score = 132 bits (330), Expect = 4e-30
Identities = 113/354 (31%), Positives = 174/354 (48%), Gaps = 36/354 (10%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M A + K +V+ ++P+PG EV+IK +C D+ RI+ P I
Sbjct: 1 MKAALLEKLNQPLSIVDREIPEPGENEVVIKQDYAGLCYRDILSATG---FFPRIQLPII 57
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
GHE+ G VV+ G V VGD+V+ +I CGKC CR G ++C K G + G
Sbjct: 58 PGHEIGGTVVKTGSEVRNFHVGDHVASLIYIPCGKCEYCRSGNENLCPYKKSIGEEVQGG 117
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTV-------LAGPISGKSVLITGA- 176
F EY VP ++ PK + Y P+ + V + LA G+ VLITGA
Sbjct: 118 FREYVNVPEISLISAPKEVDTRYL----PIASCVTGMIYHALFKLAKVKEGQRVLITGAG 173
Query: 177 GPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVIN---PFEEDVVKEVMDITD 233
G +G + +AKA GA VI S+ ++E+ +K+GADY+++ F EDV K
Sbjct: 174 GGVGSNAVQMAKAFGA-TVIAETTSESKKEMLEKIGADYIVDGNGKFNEDVKKI------ 226
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLG-LYPGKVSIDFNNLIIFKALTVYGIT 292
G D+ LE G E+ L+++ G++ ++G + P V++ LII K T+ G
Sbjct: 227 -GGADIVLECVGI-HTFERSLRSLNNGGKMIVIGNIKPDPVNLPL-GLIILKGNTIRG-- 281
Query: 293 GRHLWETWYTVSRLLQSGKLN-LDPIITHKYKGFDKYEEAFELMRAGKT-GKVV 344
+ T VS L+ N + P+I + D+ EA E+M+ +T G+V+
Sbjct: 282 --SISSTRKDVSDALKMVAENRIKPVIGSEV-SIDRINEAMEMMKNKQTEGRVL 332
>prf||2113201F carbohydrate phosphotransferase II [Escherichia coli]
Length = 346
Score = 132 bits (329), Expect = 6e-30
Identities = 101/332 (30%), Positives = 152/332 (45%), Gaps = 29/332 (8%)
Query: 31 EVLIKVIATSICGTDL--------HIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEG 82
EV +K+ ++ +CG+DL H Y P +GHE +G + VG GV+
Sbjct: 27 EVRVKIASSGLCGSDLPRIFKNGAHYY------------PITLGHEFSGYIDAVGSGVDD 74
Query: 83 IEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKS 142
+ GD V+ + C C C G Y C G DG FAEY VV +NV+ P
Sbjct: 75 LHPGDAVACVPLLPCFTCPECLYGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTD 134
Query: 143 IPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+P E EP+ + LA K+V+I GAG +GLL I A A GA V + S
Sbjct: 135 MPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDIS 194
Query: 202 DFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAG 261
+ LAK GA N E + + D + LE +G P+ +E ++ P
Sbjct: 195 SEKLALAKSFGAMQTFNSLEMSAPQMQGVLRDVRFNQLILETAGVPQTVELAVEIAGPHA 254
Query: 262 RVSLLGLYPGKVSIDFNNL--IIFKALTVYG--ITGRHLW--ETWYTVSRLLQSGKLNLD 315
+++L+G + + I+ K LTV G + W + W T SRLL KL+L+
Sbjct: 255 QLALVGTLHQDLHLTSTTFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLE 314
Query: 316 PIITHKYKGFDKYEEAF-ELMRAGKTGKVVFM 346
P+I H+ F+ + + ++ R GKV+ +
Sbjct: 315 PLIAHR-GSFESFTQVVRDIARNAMPGKVLLI 345
>gb|AAD00903.1| (AF002213) sorbitol dehydrogenase [Drosophila melanogaster]
>gi|7299382|gb|AAF54573.1| (AE003689) Sodh-2 gene
product [Drosophila melanogaster]
Length = 360
Score = 132 bits (329), Expect = 6e-30
Identities = 94/330 (28%), Positives = 159/330 (47%), Gaps = 11/330 (3%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+ EVL+ + + ICG+D+H + P I+GHE AG V ++G V +
Sbjct: 23 IPEIADDEVLLAMDSVGICGSDVHYLAHGRIGDFVLTKPMIIGHEAAGVVAKLGKKVTTL 82
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT-DGVFAEYAVVPAQNVWKNPKS 142
+VGD V++E + C C C++G+Y++C + DG Y A +K P
Sbjct: 83 KVGDRVAIEPGVPCRYCDHCKQGRYNLCADMVFCATPPYDGNLTRYYKHAADFCFKLPDH 142
Query: 143 IPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E L EPL V AG G VLI GAGP+GL+ + A+A GA +++++
Sbjct: 143 VSMEEGALLEPLSVGVHACRRAGVGLGSKVLILGAGPIGLVTLLAAQAMGASEILITDLV 202
Query: 202 DFRRELAKKVGADYVI----NPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV 257
R ++AK++GA + + + E+ VK V+ T D ++ GA + + A
Sbjct: 203 QQRLDVAKELGATHTLLLQRDQSAEETVK-VVHQTMSEVPDKSIDCCGAESSARLAIFAT 261
Query: 258 TPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPI 317
G V ++G+ +V + N + + + + G+ + L+ SGK+N+ +
Sbjct: 262 RSGGVVVVVGMGAPEVKLPLINALA-REIDIRGVF--RYCNDYSAALALVASGKVNVKRL 318
Query: 318 ITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
+TH Y + EAFE R G G + M+
Sbjct: 319 VTHHY-DITETAEAFETSRRGTGGAIKVMI 347
>gb|AAD34026.1|AF150928_4 (AF150928) AreB [Acinetobacter sp. ADP1]
Length = 371
Score = 132 bits (329), Expect = 6e-30
Identities = 102/345 (29%), Positives = 166/345 (47%), Gaps = 41/345 (11%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
EL ++ + +P EVL+K++AT +C TDL + + + P ++GHE +G + +G
Sbjct: 20 ELKQLKIREPQNDEVLVKIVATGMCHTDLIVRD----QYYPVPLPAVLGHEGSGIIEAIG 75
Query: 78 PGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDG----------- 123
P V+ + VGD+V V ++ CG C C GQ CQ+ G D DG
Sbjct: 76 PNVKDLAVGDHV-VLSYGFCGSCEQCSSGQPAYCQDFFGRNFSGGDPDGHSAVCSHDHHK 134
Query: 124 ---------VFAEYAVVPAQNVWKNPKSIPPEY-----ATLQEPLGNAVDTVLAGPISGK 169
FA YA+ N K K +P E +Q G A++ + P S
Sbjct: 135 IHDHFFAQSSFATYAISRENNAVKVSKDVPLELLGPLGCGIQTGAGAAINALKVAPAS-- 192
Query: 170 SVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVM 229
S + GAG +GL + AK GA +I + + R LAK++GA +VIN +D V+ +
Sbjct: 193 SFVTWGAGAVGLSALLAAKVCGATTIIAVDIVESRLALAKELGATHVINSKTQDPVEAIK 252
Query: 230 DITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYP--GKVSIDFNNLIIFKALT 287
+IT G GV LE +G P+ L+QG+ A+ G ++++G P + D N+L++
Sbjct: 253 EIT-GGGVKFALESTGRPEILKQGIDALGILGSIAVVGAPPLGTTAAFDVNDLLLGGKSI 311
Query: 288 VYGITGRHLWETWY-TVSRLLQSGKLNLDPIITHKYKGFDKYEEA 331
+ + G + + + + L Q GK D ++ K+ F +A
Sbjct: 312 IGVVEGSGVPKKFIPALVSLYQQGKFPFDKLV--KFYDFKDINQA 354
>pir||B83191 alcohol dehydrogenase class III PA3629 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9949788|gb|AAG07017.1|AE004783_2 (AE004783) alcohol
dehydrogenase class III [Pseudomonas aeruginosa]
Length = 370
Score = 132 bits (329), Expect = 6e-30
Identities = 115/378 (30%), Positives = 180/378 (47%), Gaps = 49/378 (12%)
Query: 2 SEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP 61
S VA KP E+VEVDV P GEVL++++AT +C TD + + S
Sbjct: 4 SRAAVAFAPNKPL---EIVEVDVAPPQKGEVLVRIVATGVCHTDAYTLSGQD---SEGVF 57
Query: 62 PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ---NTKIFG 118
P I+GHE G V VG GV ++VGD+V CGKC C G+ ++CQ T+ G
Sbjct: 58 PCILGHEGGGIVEAVGEGVTSLQVGDHVIPLYTAECGKCKFCLSGKTNLCQAVRATQGKG 117
Query: 119 VDTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT 160
+ DG F+EY V+P ++ K PK P E L LG V T
Sbjct: 118 LMPDGTSRFSYKGEPVFHYMGCSTFSEYTVLPEISLAKIPKDAPLEKVCL---LGCGVTT 174
Query: 161 VLAGPIS------GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGAD 214
+ ++ G +V I G G +GL I AK + A +I + + + ++A+++GA
Sbjct: 175 GIGAVLNTAKVEEGATVAIFGLGGIGLAAIIGAKMAKAARIIAVDINPGKFDIARELGAT 234
Query: 215 YVINP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPG 271
INP +++ + ++++TDG GVD E G + + L+ G ++G+
Sbjct: 235 DFINPKDYDKPIQDVIVELTDG-GVDYSFECVGNVQLMRAALECCHKGWGESVIIGVAGA 293
Query: 272 --KVSIDFNNLI---IFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFD 326
++S L+ +++ G+ GR ++ + Q G++ LD ITH G +
Sbjct: 294 GQEISTRPFQLVTGRVWRGSAFGGVRGRSELPSYVEKA---QKGEIPLDTFITHT-MGLE 349
Query: 327 KYEEAFELMRAGKTGKVV 344
EAFELM GK+ + V
Sbjct: 350 DINEAFELMHEGKSIRTV 367
>gb|AAD00902.1| (AF002212) sorbitol dehydrogenase [Drosophila melanogaster]
>gi|4389422|gb|AAD19792.1| (AE001574) sorbitol
dehydrogenase [Drosophila melanogaster]
>gi|7298873|gb|AAF54080.1| (AE003673) Sodh-1 gene
product [Drosophila melanogaster]
Length = 360
Score = 132 bits (328), Expect = 7e-30
Identities = 88/329 (26%), Positives = 158/329 (47%), Gaps = 9/329 (2%)
Query: 24 VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGI 83
+P+ EVL+ + + ICG+D+H + P I+GHE AG V ++G V +
Sbjct: 23 IPEIADDEVLLAMDSVGICGSDVHYLAHGRIGDFVLTKPMIIGHESAGVVAKLGKKVTTL 82
Query: 84 EVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT-DGVFAEYAVVPAQNVWKNPKS 142
+VGD V++E + C KC C++G+Y++C DG Y A +K P
Sbjct: 83 KVGDRVAIEPGVPCRKCDHCKQGKYNLCPGMVFCATPPYDGNLTRYYKHAADFCFKLPDH 142
Query: 143 IPPEYATLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPS 201
+ E L EPL V ++ G VLI GAGP+GL+ + A+A GA +++++
Sbjct: 143 VTMEEGALLEPLSVGVHACKRAEVTLGSKVLILGAGPIGLVTLMAAQAMGASEILITDLV 202
Query: 202 DFRRELAKKVGADYVINPFEEDVVKE---VMDITDGNGVDVFLEFSGAPKALEQGLQAVT 258
R ++AK++GA + + + +E ++ T G D ++ GA + + A
Sbjct: 203 QQRLDVAKELGATHTLLLKRDQTAEETAVLVQKTMGGQPDKSIDCCGAESSARLAIFATR 262
Query: 259 PAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPII 318
G V ++G+ ++ + N + + + + G+ + L+ SGK+N+ ++
Sbjct: 263 SGGIVVVVGMGAAEIKLPLINALA-REVDIRGVF--RYCNDYAAALALVASGKVNVKRLV 319
Query: 319 THKYKGFDKYEEAFELMRAGKTGKVVFML 347
TH + + +AFE R G G + M+
Sbjct: 320 THHF-DIKETAKAFETSRKGLGGAIKVMI 347
>pir||T36806 probable alcohol dehydrogenase (zinc-binding) - Streptomyces
coelicolor >gi|5441779|emb|CAB46803.1| (AL096811)
putative alcohol dehydrogenase (zinc-binding)
[Streptomyces coelicolor A3(2)]
Length = 365
Score = 131 bits (326), Expect = 1e-29
Identities = 110/364 (30%), Positives = 173/364 (47%), Gaps = 46/364 (12%)
Query: 13 PAYGA--ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVA 70
PA GA E+ +++P+PGPG V +++ A +C +DL + R+ P ++GHE A
Sbjct: 13 PAPGAPLEVTGIELPEPGPGRVRVRLAAAGVCHSDLSLSN----GTMRVPLPAVLGHEGA 68
Query: 71 GEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT------DG- 123
G VV VG GV + GD V + CG C+AC G+ +C + D DG
Sbjct: 69 GTVVAVGEGVTHVAPGDEVVLNWAPSCGACHACSLGEVWLCAHALAGAADVHARRADDGT 128
Query: 124 ---------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL------AGPISG 168
FAE VV A V P+ IP A L LG AV T A G
Sbjct: 129 DLHPGLNVAAFAEETVVAASCVLPAPEGIPLTEAAL---LGCAVLTGYGAVHHSARVREG 185
Query: 169 KSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGA-DYVINPFEEDVVKE 227
++V + G G +GL + A+ +GA ++ + S + ELA+ GA DY++ + +E
Sbjct: 186 ETVAVFGVGGVGLATLQAARIAGASKIVAVDVSPEKEELARAAGATDYLL--ASDTTARE 243
Query: 228 VMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIF---K 284
+ +T GVDV +E G + ++ GR +++G+ + FN L IF +
Sbjct: 244 IRALTGKQGVDVAVECVGRAVTIRTAWESTRRGGRTTVVGIGGKDQQVTFNALEIFHWGR 303
Query: 285 ALT--VYGIT--GRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKT 340
L+ VYG R L ++ +++G+L+L ++T + D AF+ M AGK
Sbjct: 304 TLSGCVYGNADPARDL----PVLAEHVRAGRLDLGALVTERI-ALDGIPAAFDNMLAGKG 358
Query: 341 GKVV 344
G+ +
Sbjct: 359 GRAL 362
>gi|6319258 Yal060wp [Saccharomyces cerevisiae] >gi|731293|sp|P39714|YAG0_YEAST
HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE
PROTEIN IN GDH3-CNE1 INTERGENIC REGION
>gi|1077489|pir||S51962 FUN49 protein - yeast
(Saccharomyces cerevisiae) >gi|595526|gb|AAC04974.1|
(U12980) Yal060wp [Saccharomyces cerevisiae]
Length = 382
Score = 131 bits (325), Expect = 2e-29
Identities = 110/364 (30%), Positives = 177/364 (48%), Gaps = 46/364 (12%)
Query: 23 DVPKPG---PGEVLIKVIATSICGTDLHIY-----------EWNEWAQSRIKPPQIMGHE 68
D+P+P EV+I V ICG+DLH Y E ++ + + + P MGHE
Sbjct: 17 DIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAAL--PLAMGHE 74
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGK--------------CYACRRGQYHVCQNT 114
++G V +VGP V ++VGD+V V+ C C AC+RG ++C +
Sbjct: 75 MSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHA 134
Query: 115 KIFGVDT-DGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTV-LAGPISGKSVL 172
G+ G FAE VV ++ PK IP + A L EPL V ++G G S L
Sbjct: 135 GFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSAL 194
Query: 173 ITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDIT 232
+ GAGP+GL I V K GA ++VSE ++ R E+AKK+G + V NP + + ++I
Sbjct: 195 VLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVE-VFNPSKHG--HKSIEIL 251
Query: 233 DG-----NGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNL-IIFKAL 286
G +G D + SG E L+A+T G + + ++ G + F + + +
Sbjct: 252 RGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVW-GPKPVPFQPMDVTLQEK 310
Query: 287 TVYGITGRHLWETWYTVSRLLQSGKLNLD---PIITHKYKGFDKYEEAFELMRAGKTGKV 343
+ G G ++ E + V R + +G + ++ +IT K + D +E+ F+ + K V
Sbjct: 311 VMTGSIG-YVVEAFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNV 369
Query: 344 VFML 347
+L
Sbjct: 370 KILL 373
>gb|AAK42635.1| Alcohol dehydrogenase (Zn containing) (adh-9) [Sulfolobus
solfataricus]
Length = 348
Score = 129 bits (322), Expect = 4e-29
Identities = 102/339 (30%), Positives = 167/339 (49%), Gaps = 24/339 (7%)
Query: 15 YGAELVEVDVPKPGP--GEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGE 72
YG L +VP P P GEVL+KV +T IC +DLH+ + I+GHE+AG
Sbjct: 9 YGLPLEIEEVPNPAPKEGEVLVKVASTGICHSDLHLLSGE--LVGPLPNGFIIGHEIAGW 66
Query: 73 VVEVGPGVE---GIEVGDYVSVETHIVCGKCYACRRGQYHVCQNT--KIFG-VDTDGVFA 126
V ++G V+ G++ GD V V + CG C C G+ + C++ ++ G + +G A
Sbjct: 67 VEKIGENVKNPYGLKEGDPVLVSWIVPCGICRYCANGKENYCKDNAKRLVGLIGINGGHA 126
Query: 127 EYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL-----AGPISGKSVLITGAGPLGL 181
EY VP V K++ P Y++ P+ A T A SGKSV+I GAG +G
Sbjct: 127 EYLTVPEIAVIPLAKNLDPYYSS---PIACAYGTAYNALKSANATSGKSVVIVGAGGVGS 183
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
I +A + G P++ + + + + AK +GA ++IN E D +V++ + +G D+
Sbjct: 184 AAIQLANSIGLNPIVAVDIDENKLKSAKLLGATHIINANENDARAKVLEALE-DGADIVY 242
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGL--YPGKVSIDFNNLIIFKALTVYGITGRHLWET 299
E P + L+ V G + + GL + I L + + +T+ G G
Sbjct: 243 ETKPYPD-FKLSLEVVKSGGTIVVTGLGGFSTLAQIPV-TLFVSRGITLIGSLGYRPRID 300
Query: 300 WYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAG 338
+ L SGK+++ +++H Y D EA+E ++ G
Sbjct: 301 LPDLVSLASSGKIDIKKLVSHIYTP-DMINEAYENLKKG 338
>pir||H81186 alcohol dehydrogenase, propanol-preferring NMB0546 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7225772|gb|AAF40975.1| (AE002410) alcohol
dehydrogenase, propanol-preferring [Neisseria
meningitidis MC58]
Length = 348
Score = 129 bits (322), Expect = 4e-29
Identities = 103/352 (29%), Positives = 164/352 (46%), Gaps = 21/352 (5%)
Query: 4 KMVAIMKTKPAYG-AELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
KM A++ K G E++E +V GE L++V +C TDLH+ ++ + KP
Sbjct: 2 KMQAVVVNKNVAGDVEVIEREVRPLEYGEALVEVEYCGVCHTDLHVAA-GDYGE---KPG 57
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIV-CGKCYACRRGQYHVCQNTKIFGVDT 121
+++GHE G V EV GV+ ++VGD VS+ CG C C G+ +C++ G
Sbjct: 58 RVLGHEGIGLVKEVADGVKNLKVGDRVSIAWLFQSCGSCEYCNTGRETLCRSVLNAGYTA 117
Query: 122 DGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGAGPL 179
DG A + +V A K P+ + P A+ G + +G G+ + I GAG L
Sbjct: 118 DGGMATHCIVSADYAVKVPEGLDPAQASSITCAGVTTYKAIKVSGVRPGQWIAIYGAGGL 177
Query: 180 GLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDV 239
G LG+ AK V+ + +D + AK+ GAD V+N +ED K + + T G V
Sbjct: 178 GNLGVQYAKKVFGAHVVAIDINDDKLAFAKETGADLVVNAAKEDAAKVIQEKTGGAHAAV 237
Query: 240 FLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWET 299
S A A + V GRV +GL P + + L++ V + G
Sbjct: 238 VTAVSAA--AFNSAVNCVRAGGRVVAIGLPPESMDLSIPRLVLDGIEVVGSLVG------ 289
Query: 300 WYTVSRLLQSGKLNLDPIITHK--YKGFDKYEEAFELMRAGK-TGKVVFMLK 348
T L ++ + + ++ K + D+ F+ MR GK TG++V +K
Sbjct: 290 --TRKDLEEAFQFGAEGLVVPKVQLRALDEAPAIFQEMREGKITGRMVIDMK 339
>gb|AAK40795.1| Alcohol dehydrogenase (Zn containing) (adh-1) [Sulfolobus
solfataricus]
Length = 371
Score = 128 bits (319), Expect = 9e-29
Identities = 98/344 (28%), Positives = 165/344 (47%), Gaps = 34/344 (9%)
Query: 22 VDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVE 81
+ + +P GE I++ AT +C +D++++E ++ + PP I GHE+AG + EVG V
Sbjct: 27 IQIDEPKVGETKIRIEATGLCHSDVNVFE----GKTPVPPPVIAGHEIAGVIEEVGNNVT 82
Query: 82 GIEVGDYVSVETHIVCGKCYACRRGQYHVCQ---NTKIFGVDTDGV-------------- 124
+ GD V CGKC C G+ ++C+ ++ G DG
Sbjct: 83 DFKPGDRVISAFIHPCGKCKNCITGKENLCEVFAKNRLNGTLLDGTTRLHFKDGTPIRAF 142
Query: 125 ----FAEYAVVPAQNVWKNPKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITGA 176
FAEYA+VP + K P+ + + G AV++ P G++V + G
Sbjct: 143 LGGGFAEYAMVPYTALTKVPEDLDLRKVAVLGCAGLTAYGAVNSAKIEP--GETVAVIGV 200
Query: 177 GPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNG 236
G +GL I + K +GA +I ++ E A ++GA V+N E DVV+ V +IT G G
Sbjct: 201 GGVGLSVIQMLKIAGAGRIIAVGTRKWKLEKALELGASDVVNSKETDVVRAVKNIT-GGG 259
Query: 237 VDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFK-ALTVYGITGRH 295
DV +E +G + ++ L V G+V L+GL P I I + + + G G
Sbjct: 260 PDVVIEVAGTTETVKMSLDMVRIGGKVVLVGLPPTTAEIPIRIASIVRGGIKIIGDYGGR 319
Query: 296 LWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
+ L++ GK + ++T K++ ++ EA +L+ G+
Sbjct: 320 PRVDMPRLIELVKLGKYDPTALVTGKFR-LEEINEAVKLLEQGE 362
>sp|P14940|ADH_ALCEU ALCOHOL DEHYDROGENASE >gi|78184|pir||A30196 probable alcohol
dehydrogenase (EC 1.1.1.1) - Alcaligenes eutrophus
>gi|141900|gb|AAA21953.1| (J03362) alcohol dehydrogenase
(EC 1.1.1.1) [Ralstonia eutropha]
Length = 366
Score = 128 bits (319), Expect = 9e-29
Identities = 107/376 (28%), Positives = 171/376 (45%), Gaps = 40/376 (10%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
M+ M A + +P EL + +P GP + L+++ T+ICGTD+HI + + +
Sbjct: 1 MTAMMKAAVFVEPGR-IELADKPIPDIGPNDALVRITTTTICGTDVHILK----GEYPVA 55
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRG------QYHV---- 110
+GHE G + ++G V G G V YA + G Y +
Sbjct: 56 KGLTVGHEPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQ 115
Query: 111 --CQNTKI-----FGVDTDGVFAEYAVVP--AQNVWKNPKSIPPEYATLQEPLGNAVDTV 161
C K FG DG AEY +VP N+ P + E + + + T
Sbjct: 116 CGCHGYKATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLMCPDI---MSTG 172
Query: 162 LAGPIS-----GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
G + G +V + GP+GL A A+ GA +I + +D R E+A+K+GAD V
Sbjct: 173 FKGAENANIRIGHTVAVFAQGPIGLCATAGARLCGATTIIAIDGNDHRLEIARKMGADVV 232
Query: 217 INPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSID 276
+N DVV EVM +T G GVD +E G EQ L+ + P G +S LG+Y ++I
Sbjct: 233 LNFRNCDVVDEVMKLTGGRGVDASIEALGTQATFEQSLRVLKPGGTLSSLGVYSSDLTIP 292
Query: 277 FN----NLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAF 332
+ L K T G+ E + +++SG+++L ++TH+Y+ D A+
Sbjct: 293 LSAFAAGLGDHKINTALCPGGK---ERMRRLINVIESGRVDLGALVTHQYR-LDDIVAAY 348
Query: 333 ELMRAGKTGKVVFMLK 348
+L + G + +K
Sbjct: 349 DLFANQRDGVLKIAIK 364
>sp|P41681|ADH2_PERMA ALCOHOL DEHYDROGENASE 2 >gi|1364000|pir||B49107 alcohol
dehydrogenase (EC 1.1.1.1) 2 - deer mouse
>gi|416390|gb|AAA40592.1| (L15704) alcohol dehydrogenase
2 [Peromyscus maniculatus]
Length = 375
Score = 128 bits (318), Expect = 1e-28
Identities = 104/369 (28%), Positives = 171/369 (46%), Gaps = 45/369 (12%)
Query: 12 KPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEV 69
KP + E+DV P EV +K++A ICGTD+ + ++ P P IMGHE
Sbjct: 17 KPGAPLTMEEIDVAPPKGKEVRVKMVAAGICGTDIKSLD-----NKKLAPFCPIIMGHEG 71
Query: 70 AGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD--------- 120
G V VG GV ++ GD V + CG+C C + ++C+ ++ G
Sbjct: 72 TGIVESVGEGVSTVKTGDKVIILCLPQCGECNTCLNSKNNICKEVRLSGTHLTSEGNSRI 131
Query: 121 -----------TDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAG 164
T G F+EY V+ +V K + E A + G A+++
Sbjct: 132 TCKGKTTYQYITTGTFSEYIVIKEISVAKVDEDALLEKACIIGCGFATGFGAAINSAKVS 191
Query: 165 PISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEE 222
P G + + G G +GL I KA+GA +I + + + AK VGA I+P FE+
Sbjct: 192 P--GSTCAVFGLGGVGLSVIMGCKAAGAARIIAVDTNKDKFAKAKTVGATECIDPQDFEK 249
Query: 223 DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVSIDFNNLI 281
+ + + D+ + +G D E +G P+ +E L + G ++G + ++ N+ +
Sbjct: 250 PIQQVLFDMMN-DGADFTFEVTGNPETVETALASCHKDHGVCVIVGSLASWIQLNINSHL 308
Query: 282 IFKALTVYG-ITGRHLWETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYEEAFELMRA 337
F T+ G + G W+T + +L+ + K NLDP+ITH DK EA +LM+
Sbjct: 309 FFSGRTLKGSVLGG--WKTKEEIPKLVSDYTAKKFNLDPLITHTLT-LDKVNEAIQLMKN 365
Query: 338 GKTGKVVFM 346
G+ + V +
Sbjct: 366 GQCIRCVLL 374
>sp|P42328|ADH3_BACST ALCOHOL DEHYDROGENASE (ADH-HT) >gi|628989|pir||S45605 alcohol
dehydrogenase (EC 1.1.1.1), thermostable - Bacillus
stearothermophilus (strain NCIMB 12403)
>gi|440138|emb|CAA81612.1| (Z27089) alcohol
dehydrogenase [Bacillus stearothermophilus]
Length = 339
Score = 128 bits (318), Expect = 1e-28
Identities = 108/341 (31%), Positives = 165/341 (47%), Gaps = 27/341 (7%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVE 75
++ EV+ P GEVL+++ A +C TDLH +W +KP P I GHE G V E
Sbjct: 14 KIKEVEKPTISYGEVLVRIKACGVCHTDLHAAH-GDWP---VKPKLPLIPGHEGVGIVEE 69
Query: 76 VGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQ 134
VGPGV ++VGD V + + CG C C GQ +C++ K G DG +AEY A
Sbjct: 70 VGPGVTHLKVGDRVGIPWLYSACGHCDYCLSGQETLCEHQKNAGYSVDGGYAEYCRAAAD 129
Query: 135 NVWKNPKSIPPEYATLQEPLGNAVDTV-----LAGPISGKSVLITGAGPLGLLGIAVAKA 189
V K P ++ E A P+ A T + G G+ V I G G LG + + AKA
Sbjct: 130 YVVKIPDNLSFEEAA---PIFCAGVTTYKALKVTGAKPGEWVAIYGIGGLGHVAVQYAKA 186
Query: 190 SGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKA 249
G V+ + D + ELAK++GAD V+NP +ED K + + GV + + + A
Sbjct: 187 MG-LNVVAVDIGDEKLELAKELGADLVVNPLKEDAAKFMKEKV--GGVHAAVVTAVSKPA 243
Query: 250 LEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQ- 308
+ ++ G L+GL P ++ I + ++ + I G T + LQ
Sbjct: 244 FQSAYNSIRRGGACVLVGLPPEEMPIPIFDTVLNGIKIIGSIVG-----TRKDLQEALQF 298
Query: 309 SGKLNLDPIITHKYKGFDKYEEAFELMRAGK-TGKVVFMLK 348
+ + + II + + +K E F+ M G+ G+VV L+
Sbjct: 299 AAEGKVKTII--EVQPLEKINEVFDRMLKGQINGRVVLTLE 337
>sp|P12311|ADH1_BACST ALCOHOL DEHYDROGENASE (ADH-T) >gi|282375|pir||A42654 alcohol
dehydrogenase (EC 1.1.1.1), thermostable - Bacillus
stearothermophilus (strain NCA1503)
>gi|216230|dbj|BAA14411.1| (D90421) alcohol
dehydrogenase [Bacillus stearothermophilus]
Length = 337
Score = 127 bits (316), Expect = 2e-28
Identities = 94/284 (33%), Positives = 139/284 (48%), Gaps = 18/284 (6%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVE 75
++ EV+ PK GEVL+++ A +C TDLH +W +KP P I GHE G + E
Sbjct: 14 QVKEVEKPKISYGEVLVRIKACGVCHTDLHAAH-GDWP---VKPKLPLIPGHEGVGVIEE 69
Query: 76 VGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQ 134
VGPGV ++VGD V + + CG C C GQ +C+ + G DG +AEY A
Sbjct: 70 VGPGVTHLKVGDRVGIPWLYSACGHCDYCLSGQETLCERQQNAGYSVDGGYAEYCRAAAD 129
Query: 135 NVWKNPKSIPPEYATLQEPLGNAVDTV-----LAGPISGKSVLITGAGPLGLLGIAVAKA 189
V K P ++ E A P+ A T + G G+ V I G G LG + + AKA
Sbjct: 130 YVVKIPDNLSFEEAA---PIFCAGVTTYKALKVTGAKPGEWVAIYGIGGLGHVAVQYAKA 186
Query: 190 SGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKA 249
G V+ + D + ELAK++GAD V+NP +D + + + G V S A A
Sbjct: 187 MG-LNVVAVDLGDEKLELAKQLGADLVVNPKHDDAAQWIKEKVGGVHATVVTAVSKA--A 243
Query: 250 LEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
E +++ G L+GL P ++ I + ++ + I G
Sbjct: 244 FESAYKSIRRGGACVLVGLPPEEIPIPIFDTVLNGVKIIGSIVG 287
>pir||H81915 probable alcohol dehydrogenase (EC 1.1.1.1) NMA0725 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379448|emb|CAB84010.1| (AL162754) putative alcohol
dehydrogenase [Neisseria meningitidis Z2491]
Length = 346
Score = 127 bits (316), Expect = 2e-28
Identities = 106/353 (30%), Positives = 165/353 (46%), Gaps = 25/353 (7%)
Query: 5 MVAIMKTKPAYG-AELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
M A++ K G E+VE +V GE L++V +C TDLH+ ++ + KP +
Sbjct: 1 MQAVVVNKNVAGDVEVVEREVRPLEYGEALVEVEYCGVCHTDLHVAA-GDYGE---KPGR 56
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIV-CGKCYACRRGQYHVCQNTKIFGVDTD 122
++GHE G V EV GV+ ++VGD VS+ CG C C G+ +C++ G D
Sbjct: 57 VLGHEGIGLVKEVADGVKHLKVGDRVSIAWLFQSCGSCEYCNTGRETLCRSVLNAGYTAD 116
Query: 123 GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS----GKSVLITGAGP 178
G A + +V A K P+ + P A+ G V T A +S G+ + I GAG
Sbjct: 117 GGMATHCIVSADYAVKVPEGLDPAQASSITCAG--VTTYKAIKVSSVRPGQWIAIYGAGG 174
Query: 179 LGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVD 238
LG LG+ AK V+ + +D + AK+ GAD V+N +ED K + + T G
Sbjct: 175 LGNLGVQYAKKVFGAHVVAIDINDDKLAFAKETGADLVVNAAKEDAAKVIQEKTGGAHAA 234
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWE 298
V S A A + V GRV +GL P + + L++ V + G
Sbjct: 235 VVTAVSAA--AFNSAVNCVRAGGRVVAIGLPPESMDLSIPRLVLDGIEVVGSLVG----- 287
Query: 299 TWYTVSRLLQSGKLNLDPIITHK--YKGFDKYEEAFELMRAGK-TGKVVFMLK 348
T L ++ + + ++ K + D+ F+ MR GK TG++V +K
Sbjct: 288 ---TRKDLEEAFQFGAEGLVVPKVQLRALDEAPAIFQEMREGKITGRMVIDMK 337
>sp|P80512|ADH1_NAJNA ALCOHOL DEHYDROGENASE 1 >gi|2134233|pir||S62640 alcohol
dehydrogenase (EC 1.1.1.1) I - Indian cobra
Length = 375
Score = 127 bits (315), Expect = 3e-28
Identities = 111/378 (29%), Positives = 174/378 (45%), Gaps = 48/378 (12%)
Query: 8 IMKTKPAYGAEL------VEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP 61
++K K A EL +++V P EV IK++AT +C +D H+ R+
Sbjct: 6 VIKCKAAIAWELNKPLSIEQIEVAPPKAHEVRIKILATGVCRSDEHVIS----GAFRMPL 61
Query: 62 PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FG 118
P ++GHE AG V VG GV ++ GD V CGKC AC+ + ++C + + G
Sbjct: 62 PMVLGHEAAGVVESVGEGVTCVKPGDKVIPLFAPQCGKCRACQSPKGNLCTSNDLNSGSG 121
Query: 119 VDTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLG 155
+ DG F EY VV +V K S P E L G
Sbjct: 122 LMPDGTSRFTCKGKSIHHFISTSTFTEYTVVHENSVVKIDPSAPLEKVCLIGCGFSTGYG 181
Query: 156 NAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADY 215
A+ T P G + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 182 AAMQTAKVEP--GSICAVFGLGGVGLSVVMGCKAAGASRIIGVDINKDKFAKAKEMGATE 239
Query: 216 VINP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGK 272
INP F++ + + + D+T G GVD E G + + + G ++G+ P
Sbjct: 240 CINPLDFKKPINEVLFDLTGGEGVDYSFEVIGRTETMISAFTSCHQNLGTSVVVGVPPNA 299
Query: 273 VSIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKY 328
I +N L++F T G + G W++ +V +L+ K LDP+ITH F+K
Sbjct: 300 SMITYNPLMLFTGRTWKGCVFGG--WKSKDSVPKLVSDFMQKKFVLDPLITHTLP-FEKI 356
Query: 329 EEAFELMRAGKTGKVVFM 346
E F+L+R+GK+ + V +
Sbjct: 357 NEGFDLLRSGKSIRTVLI 374
>sp|P77316|YBDR_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN IN
AHPF-RNK INTERGENIC REGION >gi|7427646|pir||F64794
probable alcohol dehydrogenase (EC 1.1.1.1) ybdR -
Escherichia coli >gi|1778526|gb|AAB40809.1| (U82598)
FadH homolog [Escherichia coli]
>gi|1786825|gb|AAC73709.1| (AE000166) putative
oxidoreductase [Escherichia coli K12]
>gi|4062224|dbj|BAA35238.1| (D90701)
Glutathione-dependent formaldehyde dehydrogenase (EC
1.2.1.1) (FDH) (FALDH). [Escherichia coli]
>gi|4062230|dbj|BAA35247.1| (D90702)
Glutathione-dependent formaldehyde dehydrogenase (EC
1.2.1.1) (FDH) (FALDH). [Escherichia coli]
Length = 412
Score = 127 bits (315), Expect = 3e-28
Identities = 116/385 (30%), Positives = 172/385 (44%), Gaps = 71/385 (18%)
Query: 9 MKTKPAYGAELVEVD-VPKPG---PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
MK +G V+V+ VP PG ++++++ AT+ICG+DLH+Y ++K I
Sbjct: 1 MKALTYHGPHHVQVENVPDPGVEQADDIILRITATAICGSDLHLYRGKI---PQVKHGDI 57
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTK--------- 115
GHE GEVVE G V+ ++ GD V + I CG C+ CR QY C+NT
Sbjct: 58 FGHEFMGEVVETGKDVKNLQKGDRVVIPFVIACGDCFFCRLQQYAACENTNAGKGAALNK 117
Query: 116 --------IFGVD-----TDGVFAEYAVVPAQNVWKNPKSIPP-----EYATLQEPLGNA 157
+FG G AEY VP NV P +PP + L + L A
Sbjct: 118 KQIPAPAALFGYSHLYGGVPGGQAEYVRVPKGNV--GPFKVPPLLSDDKALFLSDILPTA 175
Query: 158 VDTVLAGPI-SGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRREL-AKKVGADY 215
I G SV + GAGP+GLL IA A+ GA + V + +R A + GA
Sbjct: 176 WQAAKNAQIQQGSSVAVYGAGPVGLLTIACARLLGAEQIFVVDHHPYRLHFAADRYGAIP 235
Query: 216 VINPFEEDVVKEVMDITDGN-GVDVFLEFSG--------------------APKALEQGL 254
+ + D + +++ T G+ GVD ++ G + KAL Q +
Sbjct: 236 INFDEDSDPAQSIIEQTAGHRGVDAVIDAVGFEAKGSTTETVLTNLKLEGSSGKALRQCI 295
Query: 255 QAVTPAGRVSLLGLYPGKV-----SIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQS 309
AV G VS+ G+Y G + F+ + FK G T H W + L++
Sbjct: 296 AAVRRGGIVSVPGVYAGFIHGFLFGDAFDKGLSFK----MGQTHVHAW--LGELLPLIEK 349
Query: 310 GKLNLDPIITHKYKGFDKYEEAFEL 334
G L + I+TH Y F++ +E+
Sbjct: 350 GLLKPEEIVTH-YMPFEEAARGYEI 373
>pir||A82968 alcohol dehydrogenase PA5427 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9951755|gb|AAG08812.1|AE004955_6
(AE004955) alcohol dehydrogenase [Pseudomonas
aeruginosa]
Length = 342
Score = 125 bits (312), Expect = 6e-28
Identities = 99/288 (34%), Positives = 147/288 (50%), Gaps = 23/288 (7%)
Query: 14 AYGAEL--VEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ--IMGHEV 69
AYGA L EV VP PGPG+VL+K+ A+ +C TDLH E +W +KPP I GHE
Sbjct: 14 AYGAPLRIEEVKVPLPGPGQVLVKIEASGVCHTDLHAAE-GDWP---VKPPLPFIPGHEG 69
Query: 70 AGEVVEVGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEY 128
G V VG GV ++ GD V + + CG C C G +C++ + G +G +AEY
Sbjct: 70 VGYVAAVGSGVTRVKEGDRVGIPWLYTACGCCEHCLTGWETLCESQQNTGYSVNGGYAEY 129
Query: 129 AVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAG-----PISGKSVLITGAGPLGLLG 183
+ V PK++ E+A + P+ A TV G G+ V I+G G LG +
Sbjct: 130 VLADPNYVGILPKNV--EFAEI-APILCAGVTVYKGLKQTNARPGQWVAISGIGGLGHVA 186
Query: 184 IAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVM-DITDGNGVDVFLE 242
+ A+A G + V + D + ELA+K+GA +N +ED V+ + DI +GV L
Sbjct: 187 VQYARAMGLH-VAAIDIDDAKLELARKLGASLTVNARQEDPVEVLQRDIGGAHGV---LV 242
Query: 243 FSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYG 290
+ + A Q + G ++L+GL PG + ++ K L + G
Sbjct: 243 TAVSNSAFGQAIGMARRGGTIALVGLPPGDFPTPIFD-VVLKGLHIAG 289
>gb|AAK41859.1| Alcohol dehydrogenase (Zn containing) (adh-5) [Sulfolobus
solfataricus]
Length = 344
Score = 125 bits (310), Expect = 1e-27
Identities = 99/331 (29%), Positives = 158/331 (46%), Gaps = 21/331 (6%)
Query: 19 LVEVDVPK-PGPGEVLIKVIATSICGTDLHIYE--WNEWAQSRIKPPQIMGHEVAGEVVE 75
L EV+ P+ GP ++++++ +C TDLHI E W + ++ P +GHE G + E
Sbjct: 15 LDEVNKPRVSGPYDIVVRIRGAGVCRTDLHIIEGVWKDVLNPKL--PFTIGHENVGIIEE 72
Query: 76 VGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD-TDGVFAEYAVVPAQ 134
G V+ ++VGD V + +I C C ACR G C K G+D TDG +AEY A
Sbjct: 73 KGNAVDWLDVGDQVILHPYITCRHCRACRSGNDMHCPYGKFPGLDGTDGGYAEYLRTSAF 132
Query: 135 NVWKNPKSIP----PEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKAS 190
+ K PK I A +AV + G V + G G LG +GI KA
Sbjct: 133 SAIKIPKGIDIIPMAPLADAGITAYHAVKKISQYLYPGSIVGVIGVGGLGHIGIQALKAI 192
Query: 191 GAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKAL 250
VI + S+ + +LAK++GAD V+ ++ V +V+ +TD GVD ++F G
Sbjct: 193 TPARVIAIDISEEKTKLAKELGADEVVIAGKDSGVSDVLKLTDNIGVDAIIDFVGEHSTP 252
Query: 251 EQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSG 310
+ L+ + G S++G Y G+ + I + + V + G T + L +
Sbjct: 253 QNALRMIRKGGIYSIVG-YGGEFKNSTLDFINREIMVVGNLVG--------TYNELSELV 303
Query: 311 KLNLDPIITHKYKGF--DKYEEAFELMRAGK 339
L + + K K F ++ A E ++AG+
Sbjct: 304 TLYVQNKVKLKVKTFPLEEANSALEELKAGR 334
>gb|AAC04779.1| (AF036920) aryl-alcohol dehydrogenase homolog [Rhizobium tropici]
Length = 298
Score = 124 bits (309), Expect = 1e-27
Identities = 88/296 (29%), Positives = 140/296 (46%), Gaps = 39/296 (13%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
M E AI + K A L + + +P P E+L++++A+ +C TD+ + + +
Sbjct: 1 MKEAYAAISREK-AKPLVLECIGIDQPRPDEILVRIVASGVCHTDMVVRDQGY----DVP 55
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIF 117
P ++GHE +G V VG V+G+ GD+V++ ++ CGKC CR G + C++
Sbjct: 56 QPVVLGHEGSGVVEVVGADVKGLSPGDHVAL-SYAYCGKCEKCRGGTPYYCEDFFGRNFR 114
Query: 118 GVDTDGV--------------------FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNA 157
G DG FA YA+ +N K K +P E L PLG
Sbjct: 115 GTRPDGSCPLHDSHGTQISGCFFEQSSFATYAIASERNAVKVSKDVPLE---LMGPLGCG 171
Query: 158 VDTVLAG------PISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKV 211
+ T P G S+ + GAG +G+ + AK +G +IV + +D R ELA ++
Sbjct: 172 LQTGAGAVLNCLKPQPGSSIAVFGAGAVGMAAVMAAKIAGCSTIIVIDLNDERLELAIEL 231
Query: 212 GADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLG 267
GA ++IN D VK + +I G D LE + +PK Q + + G L+G
Sbjct: 232 GATHIINARNGDSVKAIREIIP-EGADFSLECTSSPKVFRQAVDCLGTPGTCGLVG 286
>pir||A83381 alcohol dehydrogenase (Zn-dependent) PA2119 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9948134|gb|AAG05507.1|AE004639_5 (AE004639) alcohol
dehydrogenase (Zn-dependent) [Pseudomonas aeruginosa]
Length = 366
Score = 124 bits (308), Expect = 2e-27
Identities = 103/362 (28%), Positives = 167/362 (45%), Gaps = 40/362 (11%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
MS+ M A + +P ELV+ +P GP + L+++ T++CGTD+HI + + +
Sbjct: 1 MSKMMKAAVFIQPGR-IELVDKPIPDVGPNDALVRITTTTLCGTDVHILK----GEYPVA 55
Query: 61 PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRG------QYHV---- 110
P +GHE G + ++G V G G V YA + G Y V
Sbjct: 56 PGLTVGHEPVGIIEKLGSAVVGYREGQRVIAGAICPNFNSYAAQDGVPSQDGSYLVESGR 115
Query: 111 --CQNTKI-----FGVDTDGVFAEYAVVP--AQNVWKNPKSIPPEYATLQEPLGNAVDTV 161
C K FG DG AEY +VP N+ P + E + + + T
Sbjct: 116 CACHGYKATAGWRFGNLIDGTQAEYVLVPDAQANLAPIPDGLSDEQVLMCPDI---MSTG 172
Query: 162 LAGPIS-----GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
G + G SV I GP+GL A A+ GA +I + + R ++A+ +GAD
Sbjct: 173 FKGAENANIRIGDSVAIFAQGPIGLCATAGARLLGASTIIAIDGNAHRLDIARGMGADVT 232
Query: 217 INPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSID 276
+N E DV++E++ +T G GVD +E G E L+ + P G +S LG+Y ++I
Sbjct: 233 LNFRECDVIEEILKLTGGRGVDASIEALGTQSTFETALRVLKPGGTLSSLGVYSEDLTIP 292
Query: 277 FN----NLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAF 332
+ L + T G+ E + ++ SG++NL P+++H+Y+ D A+
Sbjct: 293 LSAFAAGLGDHRINTALCPGGK---ERMRRLLNIVASGRVNLGPLVSHEYR-LDDIVAAY 348
Query: 333 EL 334
+L
Sbjct: 349 DL 350
>sp|P77360|YPHC_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN IN
CSIE-GLYA INTERGENIC REGION
Length = 353
Score = 124 bits (308), Expect = 2e-27
Identities = 104/338 (30%), Positives = 168/338 (48%), Gaps = 16/338 (4%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ------IMGHEVAG 71
+L EV VP PG +VLIK+ ++ ICG+D+H Y +++ + P + I GHE G
Sbjct: 16 DLREVAVPTPGINQVLIKMKSSGICGSDVH-YIYHQHRATAAAPDKPLYQGFINGHEPCG 74
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC--QNTKIFGVDTDGVFAEYA 129
++V +G G + GD V V CG C CRRG C + +G DG AEY
Sbjct: 75 QIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKAAYGWQRDGGHAEYL 134
Query: 130 VVPAQNVWKNPKSIPPE-YATLQEPLGNAVDTVLAGPISGK-SVLITGAGPLGLLGIAVA 187
+ +++ P ++ E A + +G A + +L G +SG +VL+ G GP+G++ + +A
Sbjct: 135 LAEEKDLILLPDALSYEDGAFISCGVGTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLA 194
Query: 188 KASGAYPVIVSEPSDFRRELAKKVGA-DYVINPFEEDVVKEVMDITDGNGVDVFLEFSGA 246
K GA +I + R +AK++G D+ E + + + ++T G G DV L+ SG
Sbjct: 195 KGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELTHG-GADVALDCSGN 253
Query: 247 PKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRL 306
LQ+ GRV +G GKV + + ++ + G L+ +
Sbjct: 254 AAGRLLALQSTADWGRVVYIG-ETGKVEFEVSADLMHHQRRIIGSWVTSLFH-MEKCAHD 311
Query: 307 LQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
L KL ITH++ ++ +A+ LM +GK GKVV
Sbjct: 312 LTDWKLWPRNAITHRF-SLEQAGDAYALMASGKCGKVV 348
>pir||H65031 hypothetical protein b2545 - Escherichia coli (strain K-12)
>gi|1788895|gb|AAC75598.1| (AE000340) putative
oxidoreductase [Escherichia coli K12]
>gi|1799962|dbj|BAA16447.1| (D90884) SORBITOL
DEHYDROGENASE (EC 1.1.1.14) (L-IDITOL 2-DEHYDROGENASE).
[Escherichia coli] >gi|1799970|dbj|BAA16454.1| (D90885)
SORBITOL DEHYDROGENASE (EC 1.1.1.14) (L-IDITOL
2-DEHYDROGENASE). [Escherichia coli]
Length = 364
Score = 124 bits (308), Expect = 2e-27
Identities = 104/338 (30%), Positives = 168/338 (48%), Gaps = 16/338 (4%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ------IMGHEVAG 71
+L EV VP PG +VLIK+ ++ ICG+D+H Y +++ + P + I GHE G
Sbjct: 27 DLREVAVPTPGINQVLIKMKSSGICGSDVH-YIYHQHRATAAAPDKPLYQGFINGHEPCG 85
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC--QNTKIFGVDTDGVFAEYA 129
++V +G G + GD V V CG C CRRG C + +G DG AEY
Sbjct: 86 QIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKAAYGWQRDGGHAEYL 145
Query: 130 VVPAQNVWKNPKSIPPE-YATLQEPLGNAVDTVLAGPISGK-SVLITGAGPLGLLGIAVA 187
+ +++ P ++ E A + +G A + +L G +SG +VL+ G GP+G++ + +A
Sbjct: 146 LAEEKDLILLPDALSYEDGAFISCGVGTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLA 205
Query: 188 KASGAYPVIVSEPSDFRRELAKKVGA-DYVINPFEEDVVKEVMDITDGNGVDVFLEFSGA 246
K GA +I + R +AK++G D+ E + + + ++T G G DV L+ SG
Sbjct: 206 KGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELTHG-GADVALDCSGN 264
Query: 247 PKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRL 306
LQ+ GRV +G GKV + + ++ + G L+ +
Sbjct: 265 AAGRLLALQSTADWGRVVYIG-ETGKVEFEVSADLMHHQRRIIGSWVTSLFH-MEKCAHD 322
Query: 307 LQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
L KL ITH++ ++ +A+ LM +GK GKVV
Sbjct: 323 LTDWKLWPRNAITHRF-SLEQAGDAYALMASGKCGKVV 359
>sp|P39849|XYLB_PSEPU ARYL-ALCOHOL DEHYDROGENASE (BENZYL ALCOHOL DEHYDROGENASE) (BADH)
>gi|482459|pir||A46704 aryl-alcohol dehydrogenase (EC
1.1.1.90) - Pseudomonas putida plasmid pWW0
>gi|939838|dbj|BAA09664.1| (D63341) benzyl alcohol
dehydrogenase [Pseudomonas putida]
Length = 366
Score = 124 bits (308), Expect = 2e-27
Identities = 105/363 (28%), Positives = 164/363 (44%), Gaps = 48/363 (13%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGP 78
L V + +P +VL++++AT +C TDL + + + P + GHE AG V VG
Sbjct: 17 LEHVALNEPAEDQVLVRLVATGLCHTDLVCRDQHY----PVPLPMVFGHEGAGVVERVGS 72
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDG--------------- 123
V+ ++ GD+V V T CG C AC G C N+ FG + G
Sbjct: 73 AVKKVQPGDHV-VLTFYTCGSCDACLSGDPTSCANS--FGPNFMGRSVTGECTIHDHQGA 129
Query: 124 ----------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAG------PIS 167
FA YA+ +N K K +P E L PLG + T P +
Sbjct: 130 EVGASFFGQSSFATYALSYERNTVKVTKDVPLE---LLGPLGCGIQTGAGSVLNALNPPA 186
Query: 168 GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKE 227
G ++ I GAG +GL + A +G +I + + R ELA ++GA ++INP D ++
Sbjct: 187 GSAIAIFGAGAVGLSAVMAAVVAGCTTIIAVDVKENRLELASELGATHIINPAANDPIEA 246
Query: 228 VMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYP--GKVSIDFNNLIIFKA 285
+ +I +GV LE SG P L Q + + G + ++G P V +D N L+ +
Sbjct: 247 IKEIF-ADGVPYVLETSGLPAVLTQAILSSAIGGEIGIVGAPPMGATVPVDINFLLFNRK 305
Query: 286 LTVYGITGRHLWETWY-TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
L + G+ + + + + L + GK D +I K+ FD+ A E G T K V
Sbjct: 306 LRGI-VEGQSISDIFIPRLVELYRQGKFPFDKLI--KFYPFDEINRAAEDSEKGVTLKPV 362
Query: 345 FML 347
+
Sbjct: 363 LRI 365
>gb|AAA26024.1| (M94184) xylB [Pseudomonas putida]
Length = 368
Score = 124 bits (308), Expect = 2e-27
Identities = 105/363 (28%), Positives = 164/363 (44%), Gaps = 48/363 (13%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGP 78
L V + +P +VL++++AT +C TDL + + + P + GHE AG V VG
Sbjct: 19 LEHVALNEPAEDQVLVRLVATGLCHTDLVCRDQHY----PVPLPMVFGHEGAGVVERVGS 74
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDG--------------- 123
V+ ++ GD+V V T CG C AC G C N+ FG + G
Sbjct: 75 AVKKVQPGDHV-VLTFYTCGSCDACLSGDPTSCANS--FGPNFMGRSVTGECTIHDHQGA 131
Query: 124 ----------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAG------PIS 167
FA YA+ +N K K +P E L PLG + T P +
Sbjct: 132 EVGASFFGQSSFATYALSYERNTVKVTKDVPLE---LLGPLGCGIQTGAGSVLNALNPPA 188
Query: 168 GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKE 227
G ++ I GAG +GL + A +G +I + + R ELA ++GA ++INP D ++
Sbjct: 189 GSAIAIFGAGAVGLSAVMAAVVAGCTTIIAVDVKENRLELASELGATHIINPAANDPIEA 248
Query: 228 VMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYP--GKVSIDFNNLIIFKA 285
+ +I +GV LE SG P L Q + + G + ++G P V +D N L+ +
Sbjct: 249 IKEIF-ADGVPYVLETSGLPAVLTQAILSSAIGGEIGIVGAPPMGATVPVDINFLLFNRK 307
Query: 286 LTVYGITGRHLWETWY-TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
L + G+ + + + + L + GK D +I K+ FD+ A E G T K V
Sbjct: 308 LRGI-VEGQSISDIFIPRLVELYRQGKFPFDKLI--KFYPFDEINRAAEDSEKGVTLKPV 364
Query: 345 FML 347
+
Sbjct: 365 LRI 367
>pir||T35422 probable zinc-binding alcohol dehydrogenase - Streptomyces
coelicolor >gi|4539186|emb|CAB39715.1| (AL049485)
probable zinc-binding alcohol dehydrogenase
[Streptomyces coelicolor A3(2)]
Length = 363
Score = 123 bits (306), Expect = 3e-27
Identities = 101/313 (32%), Positives = 151/313 (47%), Gaps = 40/313 (12%)
Query: 7 AIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMG 66
A + +P ++EV++ P P EVL+++ A +C TDL I + R P + G
Sbjct: 6 AAVVREPGAPFTVLEVELEDPRPREVLVRMTAAGVCHTDLGI----QAGWPRRLTPMVFG 61
Query: 67 HEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFGVDTDG 123
HE AG V VG V G+ GD V + T CG C C G C ++ + G DG
Sbjct: 62 HEGAGRVEAVGAEVTGLVPGDTVCL-TFASCGGCGQCTAGHPAYCDAARDLNLSGGRGDG 120
Query: 124 V-------------------FAEYAVVPAQNVWKNPKSIPPEYATLQEPLG----NAVDT 160
FA YAVV V + P +P ATL PLG T
Sbjct: 121 STPLRLDGAPLHGGFFGQSSFATYAVVHEHGVVRVPADLP---ATLAAPLGCGGQTGAGT 177
Query: 161 VL--AGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVIN 218
VL P G S+++ GAG +GL + A A G PV+ +P RR+LA+ +GA +
Sbjct: 178 VLNRLRPEPGTSLVVLGAGGVGLSALMAAVAVGCDPVLAVDPVASRRDLARALGARAALP 237
Query: 219 PFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFN 278
P ++ +V V +TDG G ++ +G P L++ + A+ P G ++LLGL G+V+ D
Sbjct: 238 P-DDALVAAVRQLTDG-GAHHVVDTTGRPGMLDRAVAALRPRGALALLGL-GGEVTFDMM 294
Query: 279 NLIIFKALTVYGI 291
L+ K + ++G+
Sbjct: 295 RLMT-KGVRLHGV 306
>emb|CAB64351.1| (AJ243941) putative formaldehyde dehydrogenase
(glutathione-dependent) [Pseudomonas sp.]
Length = 372
Score = 123 bits (306), Expect = 3e-27
Identities = 111/379 (29%), Positives = 178/379 (46%), Gaps = 46/379 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + P ++VEVDV P GEVL++V+AT +C TD + A S P
Sbjct: 3 KSRAAVAFAPNQPLQIVEVDVAPPKAGEVLVRVVATGVCHTDAYTL---SGADSEGVFPC 59
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVD 120
I+GHE G V VG GV + VGD+V C +C + G+ ++CQ T+ G+
Sbjct: 60 ILGHEGGGIVEAVGEGVTSLAVGDHVIPLYTAECRECKFFKSGKTNLCQKVRATQGKGLM 119
Query: 121 TDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL 162
DG F+EY V+P ++ K PK+ P E L LG V T +
Sbjct: 120 PDGTSRFSYNGQPIYHYMGCSTFSEYTVLPEISLAKIPKNAPLEKVCL---LGCGVTTGI 176
Query: 163 AGPIS------GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
++ G +V I G G +GL I AK + A +I + + + ++A+++GA
Sbjct: 177 GAVLNTAKVEEGATVAIFGLGGIGLAAIIGAKMAKASRIIAIDINPSKFDVARELGATDF 236
Query: 217 INPFE--EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
+NP + + + ++++TDG GVD E G + + L+ G ++G+ P
Sbjct: 237 VNPNDHAKPIQDVIVEMTDG-GVDYSFECIGNVRLMRAALECCHKGWGESVIIGVAPAGA 295
Query: 274 SIDFN--NLI---IFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKY 328
I+ +L+ +++ G+ GR ++ + Q G++ LD ITH G D
Sbjct: 296 EINTRPFHLVTGRVWRGSAFGGVKGRTELPSYVEKA---QQGEIPLDTFITHT-MGLDDI 351
Query: 329 EEAFELMRAGKTGKVVFML 347
AF+LM GK+ + V L
Sbjct: 352 NTAFDLMDEGKSIRSVVQL 370
>sp|P22797|ADH1_RANPE ALCOHOL DEHYDROGENASE, MAJOR >gi|104315|pir||A38405 alcohol
dehydrogenase (EC 1.1.1.1) I - Perez's frog
Length = 375
Score = 122 bits (302), Expect = 8e-27
Identities = 107/370 (28%), Positives = 165/370 (43%), Gaps = 52/370 (14%)
Query: 13 PAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGE 72
P + E++V P EV +K++AT IC +D H+ A S +K P I+GHE AG
Sbjct: 17 PKQPLSIEEIEVAPPKRHEVRVKIVATGICRSDDHVISG---ALSDMKFPVILGHEAAGV 73
Query: 73 VVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD------------ 120
V VG GV + GD V CG+C C+ + ++C I D
Sbjct: 74 VESVGEGVTKFKPGDKVIPLFVPQCGECRCCKNPESNLCYKNDIGKYDGVLLDKTSRFTC 133
Query: 121 ---------TDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPI 166
+ F EY V+ V K + P E L G+AV+T P
Sbjct: 134 KGKSIHNFISTSTFTEYTVLDEIAVAKIHEDAPLEKVCLIGCGFSTGYGSAVNTGKVKP- 192
Query: 167 SGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDV-V 225
G + + G G +GL I K +GA +I + + + AK+ GA INP + ++ +
Sbjct: 193 -GSTCAVFGLGGVGLSVIIGCKVAGASRIIGVDLNSDKFTTAKECGATECINPKDYNIPI 251
Query: 226 KEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVSIDFNNLIIFK 284
EV+ +GVD E G + L + G+ ++GL P + F+ L+I
Sbjct: 252 HEVLAKMTDDGVDYAFEVIGNTTVMTSALSSSHFGCGKTVIVGLAPSSAVMSFDPLLI-- 309
Query: 285 ALTVYGITGRHL-------WETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYEEAFEL 334
+TGR L W++ V +L++ + K + DP+ITH Y F+K E FEL
Sbjct: 310 ------LTGRILTGAVFGGWKSKDDVPKLVRDYLNKKFDFDPLITH-YMPFEKINEGFEL 362
Query: 335 MRAGKTGKVV 344
+R GK+ + +
Sbjct: 363 LRNGKSIRTI 372
>emb|CAB61162.1| (AL132973) putative Zinc-containing dehydrogenase. [Streptomyces
coelicolor A3(2)]
Length = 337
Score = 120 bits (299), Expect = 2e-26
Identities = 92/315 (29%), Positives = 142/315 (44%), Gaps = 20/315 (6%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
+M+A P+ L EV P+PGPGEVL+KV A +C +D+H+ +
Sbjct: 3 QMLAARLHVPSRTLRLEEVPRPQPGPGEVLVKVEAAGVCLSDVHLIDGTLTPLLLRGDTV 62
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDG 123
+GHEV+G V G GV G V + RR T GVD DG
Sbjct: 63 TLGHEVSGTVAGTGAGVTAWSPGQRVVLHA--------GERRDGV-----TYTRGVDYDG 109
Query: 124 VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLITGAGP 178
+AEYA+ A + P +IP E + P G +T P ++V + G G
Sbjct: 110 GWAEYALCAADAMTPLPDAIPFEQGAIIPDAVSTPWGAITETGEVRP--AEAVGVWGVGG 167
Query: 179 LGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVD 238
LG+ + + +A GA PV+ +PS RE A GAD ++ + + ++V T G G+
Sbjct: 168 LGVHAVQLLRAIGACPVVAVDPSPVARERALAAGADLALDSADPEFRQKVGAATGGAGLA 227
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWE 298
+F+G P EQ + + P GR+ L GL +++ + + G G +
Sbjct: 228 AAFDFAGVPPVREQAVSVLAPKGRLVLAGLTDKPLTVTDGTRFSYLQQRILGHYGSDMPV 287
Query: 299 TWYTVSRLLQSGKLN 313
+ RL+Q G+L+
Sbjct: 288 ALPQLLRLIQGGRLD 302
>sp|P00332|ADH_SCHPO ALCOHOL DEHYDROGENASE >gi|65898|pir||DEZPA alcohol dehydrogenase
(EC 1.1.1.1) - fission yeast (Schizosaccharomyces
pombe)
Length = 350
Score = 119 bits (296), Expect = 4e-26
Identities = 102/336 (30%), Positives = 158/336 (46%), Gaps = 21/336 (6%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV V +PG EVL+ + T +C TDLH + +W K P I GHE AG VV+VG GV
Sbjct: 25 EVPVAEPGQDEVLVNIKYTGVCHTDLHALQ-GDWPLPA-KMPLIGGHEGAGVVVKVGAGV 82
Query: 81 EGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKN 139
+++GD V V+ + CG C C + + +C + ++ G DG F Y + A +
Sbjct: 83 TRLKIGDRVGVKWMNSSCGNCEYCMKAEETICPHIQLSGYTVDGTFQHYCIANATHATII 142
Query: 140 PKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITGA-GPLGLLGIAVAKASGAYP 194
P+S+P E A G A+ GP G+ + I GA G LG L + AKA A
Sbjct: 143 PESVPLEVAAPIMCAGITCYRALKESKVGP--GEWICIPGAGGGLGHLAVQYAKAM-AMR 199
Query: 195 VIVSEPSDFRRELAKKVGADYVIN-PFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQG 253
V+ + D + EL K GA+ ++ E D+++ V T+G G L S +PK+ EQ
Sbjct: 200 VVAIDTGDDKAELVKSFGAEVFLDFKKEADMIEAVKACTNG-GAHGTLVLSTSPKSYEQA 258
Query: 254 LQAVTPAGRVSLLGLYPG-KVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKL 312
P + + + G K+ D I + + + I G H+ ++ L +
Sbjct: 259 AGFARPGSTMVTVSMPAGAKLGAD----IFWLTVKMLKICGSHVGNRIDSIEALEYVSRG 314
Query: 313 NLDPIITHKYKGFDKYEEAFELMRAGK-TGKVVFML 347
+ P +K + F + + LM K G++V L
Sbjct: 315 LVKPY--YKVQPFSTLPDVYRLMHENKIAGRIVLDL 348
>pir||T40962 alcohol dehydrogenase - fission yeast (Schizosaccharomyces pombe)
>gi|3810864|emb|CAA21782.1| (AL032681) alcohol
dehydrogenase [Schizosaccharomyces pombe]
Length = 350
Score = 119 bits (296), Expect = 4e-26
Identities = 102/336 (30%), Positives = 158/336 (46%), Gaps = 21/336 (6%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV V +PG EVL+ + T +C TDLH + +W K P I GHE AG VV+VG GV
Sbjct: 25 EVPVAEPGQDEVLVNIKYTGVCHTDLHALQ-GDWPLPA-KMPLIGGHEGAGVVVKVGAGV 82
Query: 81 EGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKN 139
+++GD V V+ + CG C C + + +C + ++ G DG F Y + A +
Sbjct: 83 TRLKIGDRVGVKWMNSSCGNCEYCMKAEETICPHIQLSGYTVDGTFQHYCIANATHATII 142
Query: 140 PKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITGA-GPLGLLGIAVAKASGAYP 194
P+S+P E A G A+ GP G+ + I GA G LG L + AKA A
Sbjct: 143 PESVPLEVAAPIMCAGITCYRALKESKVGP--GEWICIPGAGGGLGHLAVQYAKAM-AMR 199
Query: 195 VIVSEPSDFRRELAKKVGADYVIN-PFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQG 253
V+ + D + EL K GA+ ++ E D+++ V T+G G L S +PK+ EQ
Sbjct: 200 VVAIDTGDDKAELVKSFGAEVFLDFKKEADMIEAVKAATNG-GAHGTLVLSTSPKSYEQA 258
Query: 254 LQAVTPAGRVSLLGLYPG-KVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKL 312
P + + + G K+ D I + + + I G H+ ++ L +
Sbjct: 259 AGFARPGSTMVTVSMPAGAKLGAD----IFWLTVKMLKICGSHVGNRIDSIEALEYVSRG 314
Query: 313 NLDPIITHKYKGFDKYEEAFELMRAGK-TGKVVFML 347
+ P +K + F + + LM K G++V L
Sbjct: 315 LVKPY--YKVQPFSTLPDVYRLMHENKIAGRIVLDL 348
>emb|CAA07791.1| (AJ007958) dehydrogenase [Thiobacillus sp.]
Length = 422
Score = 119 bits (296), Expect = 4e-26
Identities = 98/316 (31%), Positives = 149/316 (47%), Gaps = 23/316 (7%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
E+VE++ P+ PG V++KV A+ ICGTDL Y + +Q GHE AG +VEVG
Sbjct: 93 EVVEINRPEALPGTVVVKVGASGICGTDLRAYRQDPNSQDLPH-----GHEFAGTIVEVG 147
Query: 78 PGVEGIEVGDYVSVETHI--VCGKCYACRRGQ-YHVCQNTKIFGVDTDGVFAEYAVVPAQ 134
GV +G V+ + + +CG C C G YH F G FAEY V
Sbjct: 148 EGVSRDRIGKRVTADLFLNAMCGNCQFCISGHAYHCIDKALPF---RSGGFAEYLRVRNA 204
Query: 135 NVWKNPKSIPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAY 193
+ P SI L EPL + + L G G ++ GAG +GL IA A +GA
Sbjct: 205 ATFDLPDSIDDALGALVEPLAVSTHAIRLVGVQPGMIGVVIGAGTIGLCAIAAALHAGAT 264
Query: 194 PVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKA-LEQ 252
V V F+ ELA+ +GA ++ + + ++ +G D +E G +A ++Q
Sbjct: 265 NVFVVARHAFQGELARAIGATDILPDDIGSAINRIREVAP-HGADFVIEAVGGGQATIDQ 323
Query: 253 GLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALT-----VYG-ITGRHLWETWYTVSRL 306
+ + P GRV ++G + + + K LT YG + G+H +E + L
Sbjct: 324 ATRFLAPRGRVGIVGETGPGIKVVEAYPALMKELTFLYSNCYGYLDGKHDFEV--AIENL 381
Query: 307 LQSGKLNLDPIITHKY 322
G+ L +ITH++
Sbjct: 382 ALDGE-RLRKLITHEF 396
>emb|CAC11883.1| (AL445065) sorbitol dehydrogenase related protein [Thermoplasma
acidophilum]
Length = 250
Score = 119 bits (296), Expect = 4e-26
Identities = 79/262 (30%), Positives = 126/262 (47%), Gaps = 15/262 (5%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
++ E + +P PG V ++V ICG++L + + KPP IMGHE G+VV+VG
Sbjct: 2 DIDERPLEEPQPGWVTVRVNYAGICGSELSAFVGQNELR---KPPSIMGHEFTGKVVKVG 58
Query: 78 PGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVW 137
+ +G V+V + CGKC C+ G +C K+ GVD G F EY VP+ + +
Sbjct: 59 SSSDSNLLGKNVAVNPLVTCGKCRYCKTGNRQLCPERKLIGVDYPGGFEEYVNVPSYSCY 118
Query: 138 KNPKSIPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVI 196
+ + PE +L EPL A + A P L+ GAG +GLL + + G +
Sbjct: 119 EITEK--PE-GSLAEPLATAFRAINHAKPEMDDRALVIGAGTIGLLSAKLLELYGTVERV 175
Query: 197 VSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
V++ +D+R E A GA IN +E + + DI ++ G + + +
Sbjct: 176 VTDINDYRLEHALHWGATRTINNKKEKSIPKDFDIV--------IDAVGTQETRTMAINS 227
Query: 257 VTPAGRVSLLGLYPGKVSIDFN 278
+ GRV +GL+ + N
Sbjct: 228 IARGGRVVFVGLHEPNAEMPVN 249
>pir||D70517 hypothetical protein Rv1895 - Mycobacterium tuberculosis (strain
H37RV) >gi|2225965|emb|CAB10037.1| (Z97193) hypothetical
protein Rv1895 [Mycobacterium tuberculosis]
Length = 384
Score = 119 bits (295), Expect = 6e-26
Identities = 99/332 (29%), Positives = 147/332 (43%), Gaps = 16/332 (4%)
Query: 23 DVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEG 82
D PGP V++ V A ICG+DLH YE + P +GHE G +VE GP V
Sbjct: 19 DPALPGPDGVVVAVTAAGICGSDLHFYE----GEYPFTEPVALGHEAVGTIVEAGPQVRT 74
Query: 83 IEVGDYVSVETHIVCGKCYACRRGQYHVC-QNTKIFGVDT-DGVFAEYAVVPAQN--VWK 138
+ VGD V V + CG C C +C IFG G A+ VPA + V K
Sbjct: 75 VGVGDLVMVSSVAGCGVCPGCETHDPVMCFSGPMIFGAGVLGGAQADLLAVPAADFQVLK 134
Query: 139 NPKSIPPEYA-TLQEPLGNAVDTVLAGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVI 196
P+ I E A L + L IS G +V + G G +GL + A GA V
Sbjct: 135 IPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGAVGLCALRSAFIHGAATVF 194
Query: 197 VSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
+ R + A GA P + ++ T G G D ++ G ++ L A
Sbjct: 195 AVDRVKGRLQRAATWGA----TPIPSPAAETILAATRGRGADSVIDAVGTDASMSDALNA 250
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
V P G VS++G++ + + +++T+ +T + TW + LLQSG+L++D
Sbjct: 251 VRPGGTVSVVGVHDLQPFPVPALTCLLRSITL-RMTMAPVQRTWPELIPLLQSGRLDVDG 309
Query: 317 IITHKYKGFDKYEEAFELMRAGKTGKVVFMLK 348
I T D+ + + RA ++ F L+
Sbjct: 310 IFTTTLP-LDEAAKGYATARARSGEELRFCLR 340
>pir||E72597 probable alcohol dehydrogenase APE1245 - Aeropyrum pernix (strain
K1) >gi|5104921|dbj|BAA80235.1| (AP000061) 332aa long
hypothetical alcohol dehydrogenase [Aeropyrum pernix]
Length = 332
Score = 118 bits (294), Expect = 7e-26
Identities = 104/335 (31%), Positives = 155/335 (46%), Gaps = 23/335 (6%)
Query: 15 YGAELVEV-DVPKPGPGE--VLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAG 71
YG V V D+P P E L++ A ICGTD Y K P + GHEV+G
Sbjct: 13 YGPGDVRVEDLPPPEQPEGWALVRSRAVGICGTDKAFYRGT---YPLFKKPLVPGHEVSG 69
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVV 131
EVVE G E + VG V E + C +C CR G Y C K G+D DG AEY
Sbjct: 70 EVVE---GPEDL-VGSRVVSEINFACLRCEVCREGLYTHCPRKKTLGIDFDGGMAEYFTA 125
Query: 132 PAQNVWKNPKSIPPEYATLQEPLGNAVDTV-LAGPISGKSVLITGAGPLGLLGIAVAKAS 190
P + +P ++P E A EPL ++ + A P G +V + G G + L A
Sbjct: 126 PPWAL--HPHNMPHEKAFAAEPLAAVLNALQQAPPRPGWAVAVLGTGFMAHLTAQTLTAY 183
Query: 191 GAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKAL 250
G P IV+ P + +++G + V+ P E+ VK + G G + E +G+ + L
Sbjct: 184 GFKPAIVARPDSPKAVFFRRLGLE-VLTP--EEAVKAASETPGGLGFHMVFETTGSNQGL 240
Query: 251 EQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGI-TGRHLWETWYTVSRLLQS 309
P G V + PG ++ L + K + + G G H + RLL+S
Sbjct: 241 SIATALARPRGVVHVKST-PGGEAVFSQTLAVVKEIRLIGTRCGSH--REFKEALRLLES 297
Query: 310 GKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
G+ ++P +T K++ ++ EAFE ++ K+V
Sbjct: 298 GE--VEPQVT-KFRSLEEAPEAFEASLDRESMKIV 329
>pir||C70418 probable alcohol dehydrogenase (EC 1.1.1.-) - Aquifex aeolicus
>gi|2983768|gb|AAC07327.1| (AE000736) alcohol
dehydrogenase [Aquifex aeolicus]
Length = 343
Score = 118 bits (293), Expect = 1e-25
Identities = 86/270 (31%), Positives = 141/270 (51%), Gaps = 18/270 (6%)
Query: 23 DVPKPGP--GEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVEVGP 78
D PKP P EVLI+V A ++ D+ W +KP P I+G +V+G V +VG
Sbjct: 20 DFPKPEPKEDEVLIRVKAVALNHLDI----WVRMGALPVKPELPHILGSDVSGVVEKVGS 75
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWK 138
V+ ++ G+ V + + CG C+ C+ G+ + C++ I G+ G +AEY VPA+NV K
Sbjct: 76 LVKNVKEGEEVIIAPGLSCGVCWDCQSGRDNHCKDYDILGLKNKGGYAEYVAVPARNVIK 135
Query: 139 NPKSIPPEYA-----TLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAY 193
PK++ E A T VD P S + + G+ +G+ GI +AKA A+
Sbjct: 136 KPKNLSFEEAASYPLTFLTVWNALVDKAQIKPYS-RVFIWAGSSGVGVAGIQLAKAFNAF 194
Query: 194 PVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQG 253
VI + ++ + + K++GAD V N +++DVVK+V ++ GVDV ++ G +
Sbjct: 195 -VITTAGNEEKAKKCKELGADLVFNHYKDDVVKKVREVFK-EGVDVVVDHIG-EATFWKS 251
Query: 254 LQAVTPAGRVSLLGLYPG-KVSIDFNNLII 282
+Q + G++ G G K ID + +
Sbjct: 252 VQMLRKGGKLVFFGTTTGSKGEIDIRYVFV 281
>gi|4501939 class V alcohol dehydrogenase 6; aldehyde reductase [Homo sapiens]
>gi|113389|sp|P28332|ADH6_HUMAN ALCOHOL DEHYDROGENASE 6
>gi|2144314|pir||DEHUA6 alcohol dehydrogenase (EC
1.1.1.1) 6 - human >gi|178146|gb|AAA35509.1| (M84409)
alcohol dehydrogenase 6 [Homo sapiens]
Length = 368
Score = 118 bits (292), Expect = 1e-25
Identities = 100/360 (27%), Positives = 162/360 (44%), Gaps = 41/360 (11%)
Query: 12 KPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAG 71
KP + EV+V P EV IKV+AT +CGT++ + + P I+GHE AG
Sbjct: 17 KPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLD---LLYPTILGHEGAG 73
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYH--------------------VC 111
V +G GV ++ GD V CG+C +C + + C
Sbjct: 74 IVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQSKTQLMSDGTSRFTC 133
Query: 112 QNTKIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPI 166
+ I+ F EY V+ +V K P E L G A++T P
Sbjct: 134 KGKSIYHFGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFSTGFGAAINTAKVTP- 192
Query: 167 SGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEEDV 224
G + + G G +GL + KA+GA +I + + + + A+++GA +NP ++ +
Sbjct: 193 -GSTCAVFGLGGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGATECLNPQDLKKPI 251
Query: 225 VKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKVSIDFNNLIIF 283
+ + D+TD G+D E G L L + + G ++G+ P V + + + F
Sbjct: 252 QEVLFDMTDA-GIDFCFEAIGNLDVLAAALASCNESYGVCVVVGVLPASVQLKISGQLFF 310
Query: 284 KALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
++ G + G W++ + +L+ + KLNLDP+ITH DK EA ELM+ GK
Sbjct: 311 SGRSLKGSVFGG--WKSRQHIPKLVADYMAEKLNLDPLITHTL-NLDKINEAVELMKTGK 367
>pir||T44975 dehydrogenase [imported] - Haloferax volcanii megaplasmid pHV3
>gi|2459726|gb|AAB71801.1| (U95372) dehydrogenase
[Haloferax volcanii]
Length = 389
Score = 117 bits (291), Expect = 2e-25
Identities = 100/328 (30%), Positives = 158/328 (47%), Gaps = 20/328 (6%)
Query: 29 PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDY 88
P + +I+V T+ICG+DL Y +E + +GHE G V EVG V ++ GD
Sbjct: 65 PTDAVIRVTHTAICGSDLWFYRGHEEHEEGSG----VGHEPMGIVEEVGEDVTSVQPGDR 120
Query: 89 VSVETHIVCGKCYACRRGQYHVCQNTKIFGV---DTDGVFAEYAVVPAQN--VWKNPKSI 143
V V CG+C CR+G + C + FG +T G AE V + V + P+
Sbjct: 121 VLVPFAYSCGECEFCRKGIHTACVDGGFFGPHGDETGGAQAEKVRVLHADGTVVRVPERY 180
Query: 144 PPEYATLQE--PLGNAVDT-----VLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVI 196
+ TL+ PL + + T VLA +G + ++ G G +GL G+ AK GA +I
Sbjct: 181 ADDEETLKSLLPLTDVMSTGHHAAVLADLEAGDTAVVIGDGAVGLCGVLAAKRIGAERII 240
Query: 197 VSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
+ R E+A+++GA ++ ++ V+EV+++T G G + LE GA ALE Q
Sbjct: 241 AVGHHEDRLEVARELGATDTVSSRGQEAVEEVLELTHG-GANHVLECVGAASALETAAQV 299
Query: 257 VTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDP 316
P G + +G+ P S DF I +K L+ + G + + + G L+ P
Sbjct: 300 ARPGGSIGAVGV-PHVESADFLQPIFYKNLS-FSAGGAPVRNYIEELMDDVLQGTLDPSP 357
Query: 317 IITHKYKGFDKYEEAFELMRAGKTGKVV 344
I+T K D E ++ M + KV+
Sbjct: 358 ILT-KTVDLDGVPEGYQAMDDREAIKVM 384
>pir||S35669 alcohol dehydrogenase (EC 1.1.1.1) I - American alligator
Length = 374
Score = 117 bits (290), Expect = 2e-25
Identities = 105/351 (29%), Positives = 154/351 (42%), Gaps = 39/351 (11%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
E++V P EV IK++AT IC +D H+ + P I+GHE AG V G GV
Sbjct: 25 EIEVAPPKAHEVRIKILATGICRSDDHVTA----GLLTMPLPMILGHEAAGVVESTGEGV 80
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGVDTDG-------------- 123
++ GD V CG+C C + ++C + G+ DG
Sbjct: 81 TSLKPGDKVIPLFVPQCGECMPCLKSNGNLCIRNDLGSPSGLMADGTSRFTCKGKDIHHF 140
Query: 124 ----VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLIT 174
F EY VV V + + P E L G AV P G + +
Sbjct: 141 IGTSTFTEYTVVHETAVARIDAAAPLEKVCLIGCGFSTGYGAAVKDAKVEP--GSTCAVF 198
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMDITD 233
G G +GL I KA+GA +I + + + AK++GA INP + + ++EV+
Sbjct: 199 GLGGVGLSTIMGCKAAGASRIIGIDINKDKFAKAKELGATECINPLDCKKPIQEVLSEMT 258
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTP-AGRVSLLGLYPGKVSIDFNNLIIFKALTVYGIT 292
G GVD E G + L G ++G+ P I FN +++F T G T
Sbjct: 259 GGGVDYSFEVIGRIDTMTAALACCQDNYGTSVIVGVPPASEKITFNPMMLFTGRTWKG-T 317
Query: 293 GRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKT 340
W++ +V +L+ K+NLD +ITH FDK E FEL+R GK+
Sbjct: 318 VFGGWKSKESVPKLVADYMEKKINLDGLITHTLP-FDKINEGFELLRTGKS 367
>gb|AAK42630.1| Alcohol dehydrogenase (Zn containing) (adh-8) [Sulfolobus
solfataricus]
Length = 336
Score = 116 bits (289), Expect = 3e-25
Identities = 106/346 (30%), Positives = 171/346 (48%), Gaps = 21/346 (6%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M A++ G + EV PKPG E +IKV ++C DL + R K P I
Sbjct: 1 MKAVILPAHKQGYRIEEVPDPKPGKDEAIIKVNKAALCYRDLLQIKG---FYPRSKYPLI 57
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
+GHEV G V EVG V+ + GD V+ + C C+ G+ C+N ++ + DG
Sbjct: 58 LGHEVVGTVEEVGEDVKDFKKGDRVTSMLFVPDWSCEYCKSGEEVYCKNRVVYAQELDGF 117
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGA-GPLGL 181
FAE A V A ++ K P+S+ E A + + V L AG G+ VL+TGA G +G+
Sbjct: 118 FAEKAKVKASSLVKVPESVSDEGAVIVPCVAAMVYRGLKKAGIKKGEIVLVTGASGGVGI 177
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 241
I VAKA GA + V+ + ++K ADYVI E +E I D V + +
Sbjct: 178 HAIQVAKALGAKVIGVTSGESKAKIVSKY--ADYVI--VGEKFSEEAKKIGD---VSIVI 230
Query: 242 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFN-NLIIFKALTVYGITGRHLWETW 300
E G P LE+ ++++ G++ +G V+ + II K +++ G G + +
Sbjct: 231 ENVG-PYTLEESMKSLRSGGKIIQIGNLDPSVTFNLRLGYIILKDISLMGHIGANKNDII 289
Query: 301 YTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKT--GKVV 344
T++ L++ GK+ P+I + + + +A +L+ K GK++
Sbjct: 290 KTLN-LVKEGKIK--PVIGSEV-SLENFGKALDLLNDSKNRYGKIL 331
>sp|P80222|ADH1_ALLMI ALCOHOL DEHYDROGENASE, MAJOR >gi|410008|gb|AAB28120.1| alcohol
dehydrogenase {EC 1.1.1.1} [Alligator
mississippiensis=American alligators, liver, Peptide,
374 aa]
Length = 374
Score = 116 bits (289), Expect = 3e-25
Identities = 105/352 (29%), Positives = 155/352 (43%), Gaps = 41/352 (11%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
E++V P EV IK++AT IC +D H+ + P I+GHE AG V G GV
Sbjct: 25 EIEVAPPKAHEVRIKILATGICRSDDHVTA----GLLTMPLPMILGHEAAGVVESTGEGV 80
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGVDTDG-------------- 123
++ GD V CG+C C + ++C + G+ DG
Sbjct: 81 TSLKPGDKVIPLFVPQCGECMPCLKSNGNLCIRNDLGSPSGLMADGTSRFTCKGKDIHHF 140
Query: 124 ----VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLIT 174
F EY VV V + + P E L G AV P G + +
Sbjct: 141 IGTSTFTEYTVVHETAVARIDAAAPLEKVCLIGCGFSTGYGAAVKDAKVEP--GSTCAVF 198
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMDITD 233
G G +GL I KA+GA +I + + + AK++GA INP + + ++EV+
Sbjct: 199 GLGGVGLSTIMGCKAAGASRIIGIDINKDKFAKAKELGATECINPLDCKKPIQEVLSEMT 258
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTP-AGRVSLLGLYPGKVSIDFNNLIIFKALTVYG-I 291
G GVD E G + L G ++G+ P I FN +++F T G +
Sbjct: 259 GGGVDYSFEVIGRIDTMTAALACCQDNYGTSVIVGVPPASEKITFNPMMLFTGRTWKGSV 318
Query: 292 TGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKT 340
G W++ +V +L+ K+NLD +ITH FDK E FEL+R GK+
Sbjct: 319 FGG--WKSKESVPKLVADYMEKKINLDGLITHTLP-FDKINEGFELLRTGKS 367
>gb|AAC60755.1| (S78778) class I alcohol dehydrogenase, ADH I {EC 1.1.1.1} [Apteryx
australis=brown kiwis, ssp. australis, liver, Peptide,
374 aa]
Length = 374
Score = 116 bits (288), Expect = 4e-25
Identities = 113/377 (29%), Positives = 172/377 (44%), Gaps = 45/377 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K A + +P + EV+V P EV IK++AT IC +D H+ + ++P P
Sbjct: 8 KCKAAVLWEPKKPFSIEEVEVAPPKAHEVRIKILATGICRSDDHVI-----TGALVRPFP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CG+C AC + ++C I G+
Sbjct: 63 IILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECSACLSTKGNLCSKNDIGSASGL 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F EY VV V K + P E L G
Sbjct: 123 MPDGTTRFTCKGKAIHHFIGTSTFTEYTVVHETAVAKIAAAAPLEKVCLIGCGFSTGYGA 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV T P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 183 AVQTAKVEP--GSTCAVFGLGGVGLSVVMGCKAAGASRIIAIDINKDKFAKAKELGATDC 240
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKV 273
+NP F + + + +M++T G GVD E G + + L + VS +LG+ P
Sbjct: 241 VNPKDFTKPIHEVLMEMT-GLGVDYSFEVIGHTETMAAALASCHFNYGVSVILGVPPAAE 299
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
I F+ +++F T G + G W++ V +L+ K L+P+ITH F K
Sbjct: 300 KISFDPMLLFSGRTWKGSVFGG--WKSKDAVPKLVADYMEKKFVLEPLITHTLP-FIKIN 356
Query: 330 EAFELMRAGKTGKVVFM 346
E F+L+R GK+ + V +
Sbjct: 357 EGFDLLRKGKSIRSVLV 373
>sp|P49645|ADH1_APTAU ALCOHOL DEHYDROGENASE I >gi|2147185|pir||I51312 class I alcohol
dehydrogenase - Apteryx australis
>gi|7427625|pir||S66272 alcohol dehydrogenase (EC
1.1.1.1) I - brown kiwi
Length = 375
Score = 116 bits (288), Expect = 4e-25
Identities = 113/377 (29%), Positives = 172/377 (44%), Gaps = 45/377 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K A + +P + EV+V P EV IK++AT IC +D H+ + ++P P
Sbjct: 9 KCKAAVLWEPKKPFSIEEVEVAPPKAHEVRIKILATGICRSDDHVI-----TGALVRPFP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CG+C AC + ++C I G+
Sbjct: 64 IILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECSACLSTKGNLCSKNDIGSASGL 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F EY VV V K + P E L G
Sbjct: 124 MPDGTTRFTCKGKAIHHFIGTSTFTEYTVVHETAVAKIAAAAPLEKVCLIGCGFSTGYGA 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV T P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVQTAKVEP--GSTCAVFGLGGVGLSVVMGCKAAGASRIIAIDINKDKFAKAKELGATDC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKV 273
+NP F + + + +M++T G GVD E G + + L + VS +LG+ P
Sbjct: 242 VNPKDFTKPIHEVLMEMT-GLGVDYSFEVIGHTETMAAALASCHFNYGVSVILGVPPAAE 300
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
I F+ +++F T G + G W++ V +L+ K L+P+ITH F K
Sbjct: 301 KISFDPMLLFSGRTWKGSVFGG--WKSKDAVPKLVADYMEKKFVLEPLITHTLP-FIKIN 357
Query: 330 EAFELMRAGKTGKVVFM 346
E F+L+R GK+ + V +
Sbjct: 358 EGFDLLRKGKSIRSVLV 374
>gb|AAA25324.1| (L34345) xylitol dehydrogenase [Morganella morganii]
Length = 338
Score = 116 bits (288), Expect = 4e-25
Identities = 87/315 (27%), Positives = 147/315 (46%), Gaps = 10/315 (3%)
Query: 28 GPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGD 87
G +V IK+ ICG+D+H Y+ + P ++GHE +G + G V+ ++VGD
Sbjct: 26 GDDDVEIKIHTVGICGSDVHYYQHGRIGPFVVDEPMVLGHEASGVITAAGKNVKHLKVGD 85
Query: 88 YVSVETHIVCGKCYACRRGQYHVCQNTKIFGV-DTDGVFAEYAVVPAQNVWKNPKSIPPE 146
V +E I + R G Y++ + + DG E + PA +K P ++
Sbjct: 86 RVCMEPGIPDLQSPQSRAGIYNLDPAVRFWATPPIDGCLRESVIHPAAFTFKLPDNVSFA 145
Query: 147 YATLQEPLGNAVDTVL-AGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRR 205
+ EPL + + AG G L+ GAG +G++ A A G VI+ + D +
Sbjct: 146 QGAMVEPLAIGMQSATKAGIKPGDIGLVIGAGTIGII-TQSALAGGCSDVIICDVFDEKL 204
Query: 206 ELAKKVGADYVINPFEEDVVKE-VMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS 264
++A+K + +N ++ + + V ++T G GV+V E SGA + + P G
Sbjct: 205 KVAEKYQGLHAVNSKDQQALADKVRELTGGEGVNVLFECSGAKPVIASISDHIAPGGTAV 264
Query: 265 LLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYK- 323
L+G+ +D ++ +A V T + RLL SGKLN+ P+++ YK
Sbjct: 265 LVGMPIDPAPLD---IVAAQAKEVTFKTILRYANMYPRTIRLLSSGKLNVAPLLSATYKF 321
Query: 324 --GFDKYEEAFELMR 336
+ YE A E +R
Sbjct: 322 KDSVEAYERAAEPVR 336
>sp|P41680|ADHA_PERMA ALCOHOL DEHYDROGENASE A CHAIN >gi|1363999|pir||A49107 alcohol
dehydrogenase (EC 1.1.1.1) I - deer mouse
>gi|416388|gb|AAA40591.1| (L15703) alcohol dehydrogenase
1 [Peromyscus maniculatus]
Length = 375
Score = 116 bits (287), Expect = 5e-25
Identities = 108/375 (28%), Positives = 175/375 (45%), Gaps = 45/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K A + +P + +++V P EV IK++AT +C +D H+ ++S P P
Sbjct: 9 KCKAAVLWEPHKPFSIEDIEVAPPKAHEVRIKMVATGVCRSDDHVV-----SRSLASPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
++GHE AG V VG GV ++ GD V CGKC C+ +Y++C + G
Sbjct: 64 AVLGHEGAGIVESVGEGVTSVKPGDKVIPLFTPQCGKCRICKHPEYNLCMKNDLMQPRGT 123
Query: 120 DTDGV------------------FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LLDGTSRFTCRGKAIHNFISTSTFSQYTVVDEMAVAKIDGASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV P G + + G G +GL I KA+GA +I + + + AK++GA
Sbjct: 184 AVKVAKVTP--GSTCAVFGLGGVGLSVIIGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKV 273
INP + + + + + ++TDG GVD E G + L + + VS ++G+ P
Sbjct: 242 INPLDYSKPIQEVLQEMTDG-GVDFSFEVIGRLDTMTSSLLSCHASCGVSVIVGVPPNAQ 300
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
S+ N + + + G I G +++ +V +L+ + K L+P+ITH F+K
Sbjct: 301 SLSVNPMSLLMGRSWKGAIFGG--FKSKDSVPKLVTDFMAKKFPLEPLITHVLP-FEKIN 357
Query: 330 EAFELMRAGKTGKVV 344
EAF+L+RAGK+ + V
Sbjct: 358 EAFDLLRAGKSIRTV 372
>pir||T36399 probable alcohol dehydrogenase (zinc-binding) - Streptomyces
coelicolor (fragment) >gi|5777662|emb|CAB53403.1|
(AL109987) putative alcohol dehydrogenase (zinc-binding)
[Streptomyces coelicolor A3(2)]
Length = 236
Score = 116 bits (287), Expect = 5e-25
Identities = 79/230 (34%), Positives = 115/230 (49%), Gaps = 10/230 (4%)
Query: 15 YGAELVEVDVPKP---GPGEVLIKVIATSICGTDLHIYEWNEWAQ-SRIKPPQIMGHEVA 70
YG L +VP P GP +V++++ +C TDLHI E +WA+ S ++ P +GHE A
Sbjct: 9 YGKNLEMAEVPAPEVTGPYDVIVRIGGAGVCRTDLHILE-GQWAEKSGVELPYTIGHENA 67
Query: 71 GEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAV 130
G V VG V + GD V V I CG C ACR G C+N + G+DT G +AEY
Sbjct: 68 GWVHAVGSAVTNVSEGDKVIVHPLITCGLCRACRAGDDVHCENNRFPGIDTAGGYAEYLK 127
Query: 131 VPAQNVWKNPKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITGAGPLGLLGIAV 186
A++V + S+ P G +A G ++ GAG LG +GI V
Sbjct: 128 TSARSVVRLDDSLEPADVAALADAGLTAYHAAAKAARRLRPGDRCVVIGAGGLGHIGIQV 187
Query: 187 AKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNG 236
A A ++V + + +LA VGAD+ + + V V ++T G+G
Sbjct: 188 LGALTAAEIVVVDRNPDAVDLAVSVGADHGVLA-DGGHVDRVRELTGGHG 236
>gi|4501929 class I alcohol dehydrogenase 1 alpha subunit; alcohol
dehydrogenase (class I), alpha polypeptide; aldehyde
reductase; alcohol dehydrogenase 1 (class I), alpha
polypeptide [Homo sapiens]
>gi|113390|sp|P07327|ADHA_HUMAN ALCOHOL DEHYDROGENASE
ALPHA CHAIN >gi|65886|pir||DEHUAA alcohol dehydrogenase
(EC 1.1.1.1) 1 - human >gi|178090|gb|AAA51590.1|
(M12963) alcohol dehydrogenase alpha subunit (EC
1.1.1.1) [Homo sapiens] >gi|178092|gb|AAA68131.1|
(M12271) alcohol dehydrogenase 1 [Homo sapiens]
Length = 375
Score = 115 bits (286), Expect = 6e-25
Identities = 107/375 (28%), Positives = 167/375 (44%), Gaps = 43/375 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A ICGTD H+ + + + P P
Sbjct: 11 KAAVLWELKKPFSIEEVEVAPPKAH--EVRIKMVAVGICGTDDHVV-----SGTMVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL I KA+GA +I + + + AK++GA
Sbjct: 184 AVNVAKVTP--GSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ 300
Query: 274 SIDFNNLIIFKALTVYG--ITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEA 331
++ N +++ T G + G E + + K +LD +ITH F+K E
Sbjct: 301 NLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLP-FEKINEG 359
Query: 332 FELMRAGKTGKVVFM 346
F+L+ +GK+ + + M
Sbjct: 360 FDLLHSGKSIRTILM 374
>sp|O00097|ADH1_PICST ALCOHOL DEHYDROGENASE I (ADH 2) >gi|2143328|emb|CAA73827.1|
(Y13397) alcohol dehydrogenase [Pichia stipitis]
>gi|2305088|gb|AAC49991.1| (AF008245) alcohol
dehydrogenase I [Pichia stipitis]
Length = 348
Score = 115 bits (286), Expect = 6e-25
Identities = 102/324 (31%), Positives = 149/324 (45%), Gaps = 14/324 (4%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
++ VP P P E+LI V + +C TDLH ++ +W K P + GHE AG VV +G V
Sbjct: 23 DIPVPTPKPNEILINVKYSGVCHTDLHAWK-GDWPLDT-KLPLVGGHEGAGVVVGIGSNV 80
Query: 81 EGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKN 139
G E+GDY ++ + C C C+ C + G DG F +YA A +
Sbjct: 81 TGWELGDYAGIKWLNGSCLNCEFCQHSDEPNCAKADLSGYTHDGSFQQYATADAVQAARL 140
Query: 140 PKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGA-GPLGLLGIAVAKASGAYPVI 196
PK A G V L A G V I+GA G LG L I AKA G + VI
Sbjct: 141 PKGTDLAQAAPILCAGITVYKALKTAQIQPGNWVCISGAGGGLGSLAIQYAKAMG-FRVI 199
Query: 197 VSEPSDFRRELAKKVGAD-YVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQ 255
+ + + E K +GA+ YV +D+VK++ TDG G + S + KA+ Q Q
Sbjct: 200 AIDGGEEKGEFVKSLGAEAYVDFTVSKDIVKDIQTATDG-GPHAAINVSVSEKAIAQSCQ 258
Query: 256 AVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLD 315
V G V L+GL G + + K++++ G + ++ + + L
Sbjct: 259 YVRSTGTVVLVGLPAGAKVVAPVFDAVVKSISIRGSYVGNRADSAEAIDFFTRG--LIKC 316
Query: 316 PIITHKYKGFDKYEEAFELMRAGK 339
PI K G + + +ELM AGK
Sbjct: 317 PI---KVVGLSELPKVYELMEAGK 337
>gb|AAD37848.1|AF112883_4 (AF112883) alcohol dehydrogenase [Pseudomonas sp. M1]
Length = 367
Score = 115 bits (286), Expect = 6e-25
Identities = 98/351 (27%), Positives = 156/351 (43%), Gaps = 47/351 (13%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K+ A + + G + +++ +P EVL++++ IC TDL I+PP
Sbjct: 2 KITAAVTRANSNGFSIENLELDEPRDDEVLVRIVGVGICHTDLVAAA----GVLPIQPPA 57
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV---- 119
+ GHE AG V++ G V G++ GD+V++ H CG+C CR C + +
Sbjct: 58 VFGHEGAGVVIKTGSKVTGVQSGDHVALSFHS-CGECPRCRVDDPSYCHSFGLLNFTGIR 116
Query: 120 -------DTDGV-----------FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTV 161
D G FA + V +NV K K IP E L PLG + T
Sbjct: 117 QGGSNLHDATGAAVAGNFFGQSSFASHCVANQRNVVKVSKDIPLE---LVGPLGCGIQTG 173
Query: 162 LAGPI------SGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADY 215
G + S+LI G G +GL + A G +I++EP RR LA ++GA
Sbjct: 174 FGGVARALACEADSSILILGGGAVGLSAVMAAVIRGCQQIILTEPHAARRALALELGATA 233
Query: 216 VINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGL------- 268
VI+ EDV + GV+ + SG ALE + + P L+G+
Sbjct: 234 VIDQISEDVEQLFKGFLPA-GVNYAFDTSGIGAALETAYRCLAPRATFGLVGVPQDWEQK 292
Query: 269 YPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIIT 319
PG ++ + IIFK + + G + ++ + L Q+G+L +D ++T
Sbjct: 293 LPGTLAEMVQSGIIFKGI-IEGDSDPQ--QSIPELIALYQAGRLPIDKLVT 340
>gi|11435475 alcohol dehydrogenase 1 (class I), alpha polypeptide [Homo sapiens]
Length = 399
Score = 115 bits (286), Expect = 6e-25
Identities = 107/375 (28%), Positives = 167/375 (44%), Gaps = 43/375 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A ICGTD H+ + + + P P
Sbjct: 35 KAAVLWELKKPFSIEEVEVAPPKAH--EVRIKMVAVGICGTDDHVV-----SGTMVTPLP 87
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 88 VILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGT 147
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 148 LQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 207
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL I KA+GA +I + + + AK++GA
Sbjct: 208 AVNVAKVTP--GSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATEC 265
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 266 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ 324
Query: 274 SIDFNNLIIFKALTVYG--ITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEA 331
++ N +++ T G + G E + + K +LD +ITH F+K E
Sbjct: 325 NLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLP-FEKINEG 383
Query: 332 FELMRAGKTGKVVFM 346
F+L+ +GK+ + + M
Sbjct: 384 FDLLHSGKSIRTILM 398
>dbj|BAB05730.1| (AP001514) benzyl alcohol dehydrogenase [Bacillus halodurans]
Length = 366
Score = 115 bits (284), Expect = 1e-24
Identities = 95/356 (26%), Positives = 165/356 (45%), Gaps = 41/356 (11%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV++ +P E+L+K++A+ +C TD E I P ++GHE +G V VG V
Sbjct: 19 EVELAEPKADEILVKIVASGVCHTDAVARE----QLIPIPLPAVLGHEGSGVVEAVGTHV 74
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDGV------------- 124
++ GD+V V T CG+C C+ G C FG +D
Sbjct: 75 TSVKPGDHV-VLTFTTCGECENCQSGHPSFCTEFAPLNFFGKMSDRTNRIQQNGKDVSTF 133
Query: 125 -----FAEYAVVPAQNVWKNPKSIP-----PEYATLQEPLGNAVDTVLAGPISGKSVLIT 174
F YA+ A+NV K + P +Q G ++ + P G SV I
Sbjct: 134 FGQASFGTYAIANARNVVKVDPDVDLALLGPLACGIQTGAGTVLNKLR--PEFGSSVAIF 191
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDG 234
G G +GL + AK G +I + D R LAK++GA +V N + +V+ + +T+G
Sbjct: 192 GCGAVGLSAVMAAKIVGCQKIIAIDIHDSRLALAKELGATHVFNGNDSRLVEAIQAVTNG 251
Query: 235 NGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGR 294
G + +E +G Q ++A+T G V+++G+ G V+++ N+ I+ + T+ G+
Sbjct: 252 -GTNYAVETTGISHVFHQSIKALTTLGVVAVVGV-GGDVTVNMNDDILSQGKTITGVIEG 309
Query: 295 HLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
+ + + +L+ ++G D ++ K D+ +AFE + G K + +
Sbjct: 310 DVVPQLF-IPKLIDYYKAGHFPFDRLV--KLYELDEINQAFEDSKNGSAVKPIIKM 362
>sp|P19854|ADHX_HORSE ALCOHOL DEHYDROGENASE CLASS III CHAIN (GLUTATHIONE-DEPENDENT
FORMALDEHYDE DEHYDROGENASE) (FDH) (FALDH)
>gi|89112|pir||A33419 alcohol dehydrogenase (EC 1.1.1.1)
class III - horse
Length = 373
Score = 114 bits (283), Expect = 1e-24
Identities = 112/359 (31%), Positives = 162/359 (44%), Gaps = 40/359 (11%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK+IAT++C TD + A P I+GHE AG V VG GV
Sbjct: 23 EVEVAPPKAHEVRIKIIATAVCHTDAYTL---SGADPEGSFPVILGHEGAGIVESVGEGV 79
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ---NTKIFGVDTDG-------------- 123
++ GD V CG+C C Q ++CQ T+ G+ DG
Sbjct: 80 TKLKAGDTVIPLYIPQCGECKFCLNPQTNLCQKIRTTQGKGLMPDGTSRFTCKGKTILHY 139
Query: 124 ----VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLIT 174
F+EY VV +V K P + L G AV+T P G + I
Sbjct: 140 MGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGVSTGYGAAVNTAKVEP--GSTCAIF 197
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEEDVVKEVMDIT 232
G G +GL I K +GA +I + + + AK+ GA INP F + + + ++++T
Sbjct: 198 GLGGVGLAVIMGCKVAGASRIIGVDINKDKFAKAKEFGASECINPQDFSKPIQEVLIEMT 257
Query: 233 DGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFNNLIIFKALTVYGI 291
DG GVD E G K + L+A VS ++G+ I + T G
Sbjct: 258 DG-GVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKG- 315
Query: 292 TGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
T W++ ++ +L+ S K+ +D +TH FD+ EAFELM AGK+ + V L
Sbjct: 316 TAFGGWKSVESIPKLVSEYMSKKIKVDEFVTHSL-SFDQINEAFELMHAGKSIRTVVKL 373
>pir||S34613 5-exo-hydroxycamphor dehydrogenase (EC 1.1.1.-) - Pseudomonas
putida plasmid CAM
Length = 361
Score = 114 bits (283), Expect = 1e-24
Identities = 103/351 (29%), Positives = 167/351 (47%), Gaps = 34/351 (9%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
E EV + P PG L++V+ +CG+D+HI A P I+GHE G + ++G
Sbjct: 16 ETWEVPIFDPAPGGALVRVVLGGVCGSDVHIVSGEAGAMPF---PIILGHEGIGRIEKLG 72
Query: 78 PGVE----GIEV--GDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD---GVFAEY 128
GV G+ V GD V +C +C++C C N+ F G +A++
Sbjct: 73 TGVTTDYAGVPVKQGDMVYWAPIALCHRCHSCTVLDETPCDNSTFFEHAQKPNWGSYADF 132
Query: 129 AVVP-AQNVWKNPKSIPPEYATLQEPLGNAVDTVL-----AGPIS-GKSVLITGAGPLGL 181
A +P ++ P PE LG A+ TVL GP+ +V++ GAGP+GL
Sbjct: 133 ACLPNGMAFYRLPDHAQPEALAA---LGCALPTVLRGYDRCGPVGLDDTVVVQGAGPVGL 189
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE---EDVVKEVMDITDGNGVD 238
+ VA ASGA +I + S R ++A+ +GA I+ + E+ + V + G
Sbjct: 190 AAVLVAAASGAKDIIAIDHSPIRLDMARSLGATETISLADTTPEERQRIVQERFGKRGAS 249
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYP--GKVSIDFNNLIIFKALTVYGIT---G 293
+ +E +GA A +G+ GR +LGL+ G I +L I K +++ G T
Sbjct: 250 LVVEAAGALPAFPEGVNLTGNHGRYVILGLWGAIGTQPISPRDLTI-KNMSIAGATFPKP 308
Query: 294 RHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+H ++ +RL + L +IT ++ D+ +A EL++AG K V
Sbjct: 309 KHYYQAMQLAARL--QDRYPLADLITQRF-SIDEASKALELVKAGALIKPV 356
>pdb|1HDZ|A Chain A, Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-1 Isoenzyme,
Human) Mutant With Arg 47 Replaced By Gly (R47g)
Complexed With Nad+ >gi|494092|pdb|1HDZ|B Chain B,
Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-1 Isoenzyme,
Human) Mutant With Arg 47 Replaced By Gly (R47g)
Complexed With Nad+
Length = 374
Score = 114 bits (282), Expect = 2e-24
Identities = 109/375 (29%), Positives = 166/375 (44%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A ICGTD H+ N + P P
Sbjct: 10 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICGTDDHVVSGN-----LVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 63 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 123 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 183 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 240
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 241 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 299
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 300 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 356
Query: 330 EAFELMRAGKTGKVV 344
E F+L+ +GK+ + V
Sbjct: 357 EGFDLLHSGKSIRTV 371
>gb|AAA53300.1| (U15924) alcohol dehydrogenase [Candida albicans]
Length = 350
Score = 114 bits (282), Expect = 2e-24
Identities = 106/332 (31%), Positives = 161/332 (47%), Gaps = 18/332 (5%)
Query: 16 GAELVEVD--VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEV 73
G +LV D VP P P E+LI V + +C TDLH ++ +W + K P + GHE AG V
Sbjct: 18 GGQLVYKDYPVPTPKPNELLINVKYSGVCHTDLHAWK-GDWPLAT-KLPLVGGHEGAGVV 75
Query: 74 VEVGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVP 132
V +G V+G ++GD+ ++ + C C C++G C + G DG F +YA
Sbjct: 76 VGMGENVKGWKIGDFAGIKWLNGSCMSCEFCQQGAEPNCGEADLSGYTHDGSFEQYATAD 135
Query: 133 AQNVWKNPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGAGP-LGLLGIAVAKA 189
A K P G V L A +G+ V I+GAG LG L + A+A
Sbjct: 136 AVQAAKIPAGTDLANVAPILCAGVTVYKALKTADLAAGQWVAISGAGGGLGSLAVQYARA 195
Query: 190 SGAYPVIVSEPSDFRRELAKKVGAD-YVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPK 248
G V+ + D + EL K +GA+ YV ++D+V+ V TDG G + S + K
Sbjct: 196 MGLR-VVAIDGGDEKGELVKSLGAEAYVDFTKDKDIVEAVKKATDG-GPHGAINVSVSEK 253
Query: 249 ALEQGLQAVTPAGRVSLLGL-YPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLL 307
A++Q ++ V P G+V L+GL KV+ + ++ K++ + G + +T +
Sbjct: 254 AIDQSVEYVRPLGKVVLVGLPAHAKVTAPVFDAVV-KSIEIKGSYVGNRKDTAEAID--F 310
Query: 308 QSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
S L PI K G + E F+LM GK
Sbjct: 311 FSRGLIKCPI---KIVGLSELPEVFKLMEEGK 339
>dbj|BAA35108.1| (AB020760) Phenylacetaldehyde reductase [Corynebacterium sp. ST-10]
Length = 385
Score = 114 bits (282), Expect = 2e-24
Identities = 82/277 (29%), Positives = 127/277 (45%), Gaps = 11/277 (3%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M AI T+ EL E+ P+PGPGEVL++V A +C +D I E Q P
Sbjct: 1 MKAIQYTRIGAEPELTEIPKPEPGPGEVLLEVTAAGVCHSDDFIMSLPE-EQYTYGLPLT 59
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD---- 120
+GHE AG+V VG GVEG+++G V V CG C+ C +G + C + G++
Sbjct: 60 LGHEGAGKVAAVGEGVEGLDIGTNVVVYGPWGCGNCWHCSQGLENYCSRAQELGINPPGL 119
Query: 121 -TDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLG----NAVDTVLAGPISGKSVLITG 175
G AE+ +V + + P G +A+ L G ++ G
Sbjct: 120 GAPGALAEFMIVDSPRHLVPIGDLDPVKTVPLTDAGLTPYHAIKRSLPKLRGGSYAVVIG 179
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGN 235
G LG + I + + A VI + S + ELA KVGA V+ ++D + V IT
Sbjct: 180 TGGLGHVAIQLLRHLSAATVIALDVSADKLELATKVGAHEVVLS-DKDAAENVRKITGSQ 238
Query: 236 GVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGK 272
G + L+F G ++ + V+++G+ G+
Sbjct: 239 GAALVLDFVGYQPTIDTAMAVAGVGSDVTIVGIGDGQ 275
>gb|AAF73255.1|AF156708_1 (AF156708) alcohol dehydrogenase class III [Branchiostoma
lanceolatum]
Length = 377
Score = 114 bits (282), Expect = 2e-24
Identities = 102/354 (28%), Positives = 167/354 (46%), Gaps = 46/354 (12%)
Query: 22 VDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVE 81
++V P EV IKV+AT +C TD + + + S K P ++GHE G V VG GV
Sbjct: 28 IEVAPPRAHEVRIKVLATGVCHTDAYTLDGFD---SEGKFPVVLGHEGGGVVESVGEGVS 84
Query: 82 GIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GVDTDG--------------- 123
G + GD+V C +C C+ + ++CQ ++ GV DG
Sbjct: 85 GFKPGDHVIPLYVPQCKECKFCKSPKTNLCQKIRVTQGQGVMPDGSTRFTCKGQTVFHFM 144
Query: 124 ---VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPI------SGKSVLIT 174
F+EY VV ++ K +S P + L LG + T + SG +V +
Sbjct: 145 GTSTFSEYTVVADISLCKVTESAPLDKVCL---LGCGISTGYGAALNTAKVESGSTVAVW 201
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDIT 232
G G +GL I AK +GA +I + + + E+AKK G +NP + D + + ++++T
Sbjct: 202 GLGAVGLAVIMGAKVAGASRIIGVDINPDKAEIAKKFGMTEFVNPKDHDKPIQQVLVELT 261
Query: 233 DGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKVSIDFNNLIIFKALT--VY 289
DG G+D E G + L++ G ++G+ I F+ +T V+
Sbjct: 262 DG-GLDFTFECIGNVHTMRAALESCHKGWGTSVIIGVAAAGQEISTRP---FQLVTGRVW 317
Query: 290 GITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKT 340
T W++ +V +L+ QSGK+ +D I+H + DK ++F LM AG++
Sbjct: 318 KGTAFGGWKSVDSVPKLVEEYQSGKIQVDEFISHNFP-LDKINDSFHLMHAGES 370
>gi|11499684 alcohol dehydrogenase, zinc-dependent [Archaeoglobus fulgidus]
>gi|7482899|pir||E69512 alcohol dehydrogenase,
zinc-dependent homolog - Archaeoglobus fulgidus
>gi|2648422|gb|AAB89145.1| (AE000958) alcohol
dehydrogenase, zinc-dependent [Archaeoglobus fulgidus]
Length = 402
Score = 113 bits (281), Expect = 2e-24
Identities = 103/360 (28%), Positives = 159/360 (43%), Gaps = 54/360 (15%)
Query: 27 PGPGEVLIKVIATSICGTDLHIYEWNE--WAQSRIKPPQIMGHEVAGEVVEVGPGVEGIE 84
P V +K ICG+DL I E + P I GHEV GEVVEVG + E
Sbjct: 46 PDEDWVKVKTRLCGICGSDLRIITLQESFYLAPLTSFPFIPGHEVVGEVVEVGKEADAQE 105
Query: 85 VGDYVSVETHIVC-----GKCYACRRGQYHVCQNTKIFGV----------DTDGVFAEYA 129
G+ V + T + C C ACR+G + C N + DT G +AEY
Sbjct: 106 -GERVVINTALSCRVRGFDDCDACRKGHFAACHNVDRGRISPGIFTGTCRDTGGGWAEYF 164
Query: 130 VVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAG-PISGKSVLITGAGPLGLLGIAVAK 188
V + + P+ I E A EPL + + L P G+ V I G G +G+ I +
Sbjct: 165 VAHESQLVRVPEGIRDENAVFAEPLTIGIHSALRSFPDDGEVVAIVGCGVIGICTIIALR 224
Query: 189 ASGAYPVIVS-EPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGN------------ 235
G I+ + S+ + ELA+K GAD V+ E+ V+ + ++T G
Sbjct: 225 HLGFRGEIIGIDISERQAELARKFGADGVVT---ENPVERIAEMTGGRVYRPPRDKPMFI 281
Query: 236 --GVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
GVDV E +G P+ ++ L+ P GRV + G K+ +D+ + K L+V G G
Sbjct: 282 GGGVDVAFECTGIPQTVDTALRITKPLGRVVIAGTV-AKMGVDWAP-VFAKELSVLGTFG 339
Query: 294 ----------RHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R ++ + + + K++L ++TH++ D + + GK+G V
Sbjct: 340 CGIEEVNGEKRDAFDIAFEILK-----KVDLSSLLTHRFTIEDYKKALRAAIEKGKSGAV 394
>gb|AAF73254.1|AF154331_1 (AF154331) alcohol dehydrogenase class III [Branchiostoma floridae]
Length = 377
Score = 113 bits (281), Expect = 2e-24
Identities = 105/353 (29%), Positives = 162/353 (45%), Gaps = 44/353 (12%)
Query: 22 VDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVE 81
++V P EV IKV+AT +C TD + A S K P ++GHE G V VG GV
Sbjct: 28 IEVAPPKAHEVRIKVLATGVCHTDAYTLSG---ADSEGKFPVVLGHEGGGVVESVGEGVT 84
Query: 82 GIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GVDTDG--------------- 123
G + GD+V C C CR + ++CQ ++ GV DG
Sbjct: 85 GFQPGDHVIPLYIPQCRDCKFCRSPKTNLCQKIRVSQGQGVMPDGSSRFTCKGQTVYHFM 144
Query: 124 ---VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLITG 175
F+EY VV ++ K +S P E L G A++T P G +V + G
Sbjct: 145 GTSTFSEYTVVADISLCKVAESAPLEKVCLLGCGISTGYGAALNTAKVEP--GSTVAVWG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL I AK +GA +I + + + E+A+K G +NP + D + + + D+TD
Sbjct: 203 LGAVGLAVIMGAKVAGASRIIGVDINPDKAEIAQKFGMTEFVNPKDHDRPIQQVLADMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKVSIDFNNLIIFKALT--VYG 290
G G+D E G + L+A G ++G+ I F+ +T V+
Sbjct: 263 G-GLDYTFECIGNVHTMRAALEACHKGWGTSVIIGVAAAGQEISTRP---FQLVTGRVWK 318
Query: 291 ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKT 340
T W++ +V RL+ Q+GK+ +D I+H + D E+F LM G++
Sbjct: 319 GTAFGGWKSVESVPRLVGEYQAGKIKVDEFISHTFP-LDNINESFRLMHDGES 370
>sp|P12886|ADH1_PEA ALCOHOL DEHYDROGENASE 1 >gi|81891|pir||S00912 alcohol dehydrogenase
(EC 1.1.1.1) 1 - garden pea >gi|20639|emb|CAA29609.1|
(X06281) alcohol dehydrogenase [Pisum sativum]
Length = 380
Score = 113 bits (280), Expect = 3e-24
Identities = 112/391 (28%), Positives = 174/391 (43%), Gaps = 55/391 (14%)
Query: 1 MSEKMVAIMKTKPAYGAE------LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEW 54
MS + I+K + A E + EV+V P GEV +K++ TS+C TD +Y W
Sbjct: 1 MSNTVGQIIKCRAAVAWEAGKPLVIEEVEVAPPQAGEVRLKILFTSLCHTD--VYFWEAK 58
Query: 55 AQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNT 114
Q+ + P +I GHE G V VG GV ++ GD+ CG+C C+ + ++C
Sbjct: 59 GQTPLFP-RIFGHEAGGIVESVGEGVTHLKPGDHALPVFTGECGECPHCKSEESNMCDLL 117
Query: 115 KI--------------FGVDTDGV--------FAEYAVVPAQNVWK-NPKSIPPEYATLQ 151
+I F + V F+EY VV A V K NP + + L
Sbjct: 118 RINTDRGVMLNDNKSRFSIKGQPVHHFVGTSTFSEYTVVHAGCVAKINPDAPLDKVCILS 177
Query: 152 EPLGNAVDTVL--AGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAK 209
+ + + A P G SV I G G +GL A+ SGA +I + R ELAK
Sbjct: 178 CGICTGLGATINVAKPKPGSSVAIFGLGAVGLAAAEGARISGASRIIGVDLVSSRFELAK 237
Query: 210 KVGADYVINPFEED--VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLG 267
K G + +NP E D V + + ++T+G GVD +E +G+ +A+ + V V++L
Sbjct: 238 KFGVNEFVNPKEHDKPVQQVIAEMTNG-GVDRAVECTGSIQAMISAFECVHDGWGVAVLV 296
Query: 268 LYPGKVSIDFNNLIIFKALTVYGITGRHLWETWY----------TVSRLLQSGKLNLDPI 317
P K FK + + R L T+Y V G+L L+
Sbjct: 297 GVPSKDD-------AFKTHPMNFLNERTLKGTFYGNYKPRTDLPNVVEKYMKGELELEKF 349
Query: 318 ITHKYKGFDKYEEAFELMRAGKTGKVVFMLK 348
ITH F + +AF+ M G++ + + ++
Sbjct: 350 ITHTVP-FSEINKAFDYMLKGESIRCIIKME 379
>pir||B70853 probable adhD protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2808433|emb|CAA16144.1| (AL021309) adhD
[Mycobacterium tuberculosis]
Length = 368
Score = 113 bits (280), Expect = 3e-24
Identities = 104/358 (29%), Positives = 164/358 (45%), Gaps = 49/358 (13%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVE 75
EL+E+D+ PGPGEVL+K A +C +DLH+ + + + P P + GHE +G + E
Sbjct: 16 ELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGD------LPPRFPIVGGHEGSGVIEE 69
Query: 76 VGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC--------------------QNTK 115
VG GV ++ GD+V CG C C G+ ++C Q T
Sbjct: 70 VGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGSFRFHSQGTD 129
Query: 116 IFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPI-SGK 169
+ G FAE A V +V K +P E A L G AV+ AG + +G
Sbjct: 130 FGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVN---AGNLRAGD 186
Query: 170 SVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVM 229
+ +I G G LG+ + A A+G V+V +P F+RE A K GA + K V
Sbjct: 187 TAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASAAAK-VD 245
Query: 230 DITDGNGVDVFLEFSGA--PKALEQGLQAVTPAGRVSLLGLY-PGKVSIDFN--NLIIFK 284
++T G G D L G + + + G V + GL P K+++ + +L + +
Sbjct: 246 ELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHE 305
Query: 285 ALTVYGITGRHLWETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
+ G Y + RLL+ +G+L LD ++T Y ++ + ++ +R GK
Sbjct: 306 KTIKGSLFGS--CNPQYDIVRLLRLYDAGQLMLDELVTTTY-NLEQVNQGYQDLRDGK 360
>gb|AAC15839.1| (AF060871) hypothetical alcohol dehydrogenase [Rhodococcus
rhodochrous]
Length = 370
Score = 113 bits (280), Expect = 3e-24
Identities = 100/357 (28%), Positives = 160/357 (44%), Gaps = 52/357 (14%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWN-EWAQSRIKPPQIMGHEVAGEVVEVGPG 79
E+D+ P GEVL+++ + +C +D H+ + W P + GHE AG VVEVGPG
Sbjct: 20 EIDLDPPRHGEVLVEMGGSGLCHSDEHVLTGDLPWPL-----PMVGGHEGAGTVVEVGPG 74
Query: 80 VEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD----------------- 122
VEG+ GD V CG+C AC G ++C+ + G T
Sbjct: 75 VEGLAAGDRVIFGFLPACGRCAACSAGMQNLCELGQYLGDGTQISDHTSRHHARGQDLGL 134
Query: 123 ----GVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VLAGPIS-GKSVL 172
G FA++ VV N K I + A L LG V T V G + G + +
Sbjct: 135 MCLLGTFAQHTVVSEANCIKIDDDIALDKACL---LGCGVVTGWGSAVFTGGVKPGDTSV 191
Query: 173 ITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDIT 232
+ G G +G+ + A +G+ V+ +P +F+R A ++GA + + EE V D+T
Sbjct: 192 VVGVGGIGINAVQGAAMNGSQYVVAVDPVEFKRTKALELGATHAVATSEE-AQALVADLT 250
Query: 233 DGNGVDVFLEFSGAPKALEQG--LQAVTPAGRVSLLGLYPG---KVSIDFNNLIIFKALT 287
G G +V + +G + + G L G V + L+ V + +L++ +
Sbjct: 251 YGRGANVVVNTTGVGEGDQIGASLAMTAKRGTVVVTNLHRATEETVKMSALDLVLMEKRV 310
Query: 288 VYGITGR-----HLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
V + G H+ + + L +SG L LD + T YK D+ ++ MR G+
Sbjct: 311 VGSLFGSANPRLHIPK----MLGLYRSGHLKLDELATRSYK-LDEVNTGYQDMREGR 362
>sp|P13603|ADH1_TRIRP ALCOHOL DEHYDROGENASE 1 >gi|65900|pir||DEJYAW alcohol dehydrogenase
(EC 1.1.1.1) 1 - white clover >gi|21951|emb|CAA32934.1|
(X14826) alcohol dehydrogenase I (AA 1-380) [Trifolium
repens]
Length = 380
Score = 113 bits (279), Expect = 4e-24
Identities = 107/365 (29%), Positives = 164/365 (44%), Gaps = 49/365 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P GEV +K++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 27 EVEVAPPQAGEVRLKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 83
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI--------------FGVDTDGV-- 124
++ GD+ CG+C C+ + ++C +I F + V
Sbjct: 84 THLKPGDHALPVFTGECGECPHCKSEESNMCNLLRINTDRGVMINDNKSRFSIKGQPVHH 143
Query: 125 ------FAEYAVVPAQNVWK-NPKSIPPEYATLQEPL--GNAVDTVLAGPISGKSVLITG 175
F+EY VV A V K NP + + L + G +A P G SV I G
Sbjct: 144 FVGTSTFSEYTVVHAGCVAKINPDAPLDKVCILSCGICTGLGATVNVAKPKPGSSVAIFG 203
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ SGA +I + R ELAKK G + +NP + D V + + ++TD
Sbjct: 204 LGAVGLAAAEGARMSGASRIIGVDLVSSRFELAKKFGVNEFVNPKDHDKPVQQVIAEMTD 263
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ + V V++L P K FK + +
Sbjct: 264 G-GVDRAVECTGSIQAMISAFECVHDGWGVAVLVGVPKKDD-------AFKTHPMNFLNE 315
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T+Y V G+L L+ ITH F + +AF+ M G++ +
Sbjct: 316 RTLKGTFYGNYKPRTDLPNVVEQYMKGELELEKFITHSIP-FSEINKAFDYMLKGESIRC 374
Query: 344 VFMLK 348
+ ++
Sbjct: 375 IIRME 379
>gb|AAA51884.1| (M24317) alcohol dehydrogenase beta subunit [Homo sapiens]
Length = 375
Score = 113 bits (279), Expect = 4e-24
Identities = 108/375 (28%), Positives = 166/375 (43%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 11 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICRTDDHVVSGN-----LVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 123
Query: 120 DTDGV------------------FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + ++ AK++GA
Sbjct: 184 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKKAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 300
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 301 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 357
Query: 330 EAFELMRAGKTGKVV 344
E F+L+ +GK+ + V
Sbjct: 358 EGFDLLHSGKSIRTV 372
>pir||S53308 alcohol dehydrogenase (EC 1.1.1.1) 1CN - Phaseolus acutifolius
>gi|452767|emb|CAA80692.1| (Z23171) alcohol
dehydrogenase-1CN [Phaseolus acutifolius]
Length = 380
Score = 113 bits (279), Expect = 4e-24
Identities = 112/389 (28%), Positives = 169/389 (42%), Gaps = 53/389 (13%)
Query: 1 MSEKMVAIMKTKPAYGAE------LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEW 54
MS ++K K A E + EV+V P GEV +K++ TS+C TD +Y W
Sbjct: 1 MSSTAGQVIKCKAAVAWEAGKPLVMEEVEVAPPKAGEVRLKILYTSLCHTD--VYFWEAK 58
Query: 55 AQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNT 114
Q+ + P +I GHE G V VG GV ++ GD+ CG+C C+ + ++C
Sbjct: 59 GQTPLFP-RIFGHEAGGIVESVGEGVTHLKPGDHALPVFTGECGECAHCKSEESNMCDLL 117
Query: 115 KI--------------FGVDTDGV--------FAEYAVVPAQNVWK-NPKSIPPEYATLQ 151
+I F + + F+EY VV A V K NP + + L
Sbjct: 118 RINTDRGVMIHDSQTRFSIKGQPIYHSVGTSTFSEYTVVHAGCVAKVNPAAPLDKICVLS 177
Query: 152 EPL--GNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAK 209
+ G +A P G SV I G G +GL A+ SGA +I + R E AK
Sbjct: 178 CGICTGLGATVNVAKPKPGSSVAIFGLGAVGLAAAEGARISGASRIIGVDLVSSRFEEAK 237
Query: 210 KVGADYVINPFEED-VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGL 268
K G + +NP + D V+EV+ GVD +E +G+ +A+ + V V++L
Sbjct: 238 KFGVNEFVNPKDHDKPVQEVIAEMTNGGVDRAVECTGSIQAMISAFECVHDGWGVAVLVG 297
Query: 269 YPGKVSIDFNNLIIFKALTVYGITGRHLWETWY----------TVSRLLQSGKLNLDPII 318
P K FK V + R L T+Y V +G+L LD I
Sbjct: 298 VPNKDD-------AFKTHPVNFLNERTLKGTFYGNYKPRTDLPLVVEQYMNGELELDKFI 350
Query: 319 THKYKGFDKYEEAFELMRAGKTGKVVFML 347
TH F + +AF+ M G++ + + +
Sbjct: 351 THTVP-FSEINKAFDYMLKGESIRCIIRM 378
>pir||S53307 alcohol dehydrogenase (EC 1.1.1.1) 1 - Phaseolus acutifolius
>gi|452769|emb|CAA80691.1| (Z23170) alcohol
dehydrogenase-1F [Phaseolus acutifolius]
Length = 380
Score = 113 bits (279), Expect = 4e-24
Identities = 112/389 (28%), Positives = 169/389 (42%), Gaps = 53/389 (13%)
Query: 1 MSEKMVAIMKTKPAYGAE------LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEW 54
MS ++K K A E + EV+V P GEV +K++ TS+C TD +Y W
Sbjct: 1 MSSTAGQVIKCKAAVAWEAGKPLVMEEVEVAPPKAGEVRLKILYTSLCHTD--VYFWEAK 58
Query: 55 AQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNT 114
Q+ + P +I GHE G V VG GV ++ GD+ CG+C C+ + ++C
Sbjct: 59 GQTPLFP-RIFGHEAGGIVESVGEGVTHLKPGDHALPVFTGECGECAHCKSEESNMCDLL 117
Query: 115 KI--------------FGVDTDGV--------FAEYAVVPAQNVWK-NPKSIPPEYATLQ 151
+I F + + F+EY VV A V K NP + + L
Sbjct: 118 RINTDRGVMIHDSQTRFSIKGQPIYHFVGTSTFSEYTVVHAGCVAKVNPAAPLDKICVLS 177
Query: 152 EPL--GNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAK 209
+ G +A P G SV I G G +GL A+ SGA +I + R E AK
Sbjct: 178 CGICTGLGATVNVAKPKPGSSVAIFGLGAVGLAAAEGARISGASRIIGVDLVSSRFEEAK 237
Query: 210 KVGADYVINPFEED-VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGL 268
K G + +NP + D V+EV+ GVD +E +G+ +A+ + V V++L
Sbjct: 238 KFGVNEFVNPKDHDKPVQEVIAEMTNGGVDRAVECTGSIQAMISAFECVHDGWGVAVLVG 297
Query: 269 YPGKVSIDFNNLIIFKALTVYGITGRHLWETWY----------TVSRLLQSGKLNLDPII 318
P K FK V + R L T+Y V +G+L LD I
Sbjct: 298 VPNKDD-------AFKTHPVNFLNERTLKGTFYGNYKPRTDLPLVVEQYMNGELELDKFI 350
Query: 319 THKYKGFDKYEEAFELMRAGKTGKVVFML 347
TH F + +AF+ M G++ + + +
Sbjct: 351 THTVP-FSEINKAFDYMLKGESIRCIIRM 378
>sp|P39450|ADH3_PASPI PUTATIVE ALCOHOL DEHYDROGENASE CLASS III (GLUTATHIONE-DEPENDENT
FORMALDEHYDE DEHYDROGENASE) (FDH) (FALDH)
Length = 369
Score = 113 bits (279), Expect = 4e-24
Identities = 105/363 (28%), Positives = 166/363 (44%), Gaps = 38/363 (10%)
Query: 13 PAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGE 72
P E+VE+DV P GEVL+K+ T +C TD + ++ P ++GHE AG
Sbjct: 11 PGLPLEIVEIDVAPPKKGEVLVKISHTGVCHTDAYTLSGDD---PEGLFPVVLGHEGAGV 67
Query: 73 VVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFGVDTD------- 122
VVEVG GV ++ GD+V CG+C C G+ ++C + T+ GV D
Sbjct: 68 VVEVGEGVTSVKPGDHVIPLYTAECGECDFCTSGKTNLCVAVRETQGKGVMPDATSRFFV 127
Query: 123 -----------GVFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTV--LAGPISG 168
F+EY VV ++ K NP++ + L + + V A G
Sbjct: 128 NGQPLYHYMGCSTFSEYTVVAEVSLAKINPQANAEQVCLLGCGVTTGIGAVHNTAKVQEG 187
Query: 169 KSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED-VVKE 227
SV + G G +GL + A+ + A + + + + ELAK+ GA INP + D V++
Sbjct: 188 DSVAVFGLGGIGLAVVQGARQAKAGRIFAIDTNPSKFELAKQFGATDCINPNDYDKPVQQ 247
Query: 228 VMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPG--KVSIDFNNLI--- 281
V+ GVD E G + L++ G+ ++G+ ++S L+
Sbjct: 248 VLVEMTKWGVDHTFECIGNVNVMRSALESAHRGWGQSVIIGVAGAGKEISTRPFQLVTGR 307
Query: 282 IFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTG 341
++K G+ GR + SGK+ L P +TH + DK EAF+LM GK+
Sbjct: 308 VWKGTAFGGVKGRTQLPGMVEDA---MSGKIELAPFVTHTME-LDKINEAFDLMHDGKSI 363
Query: 342 KVV 344
+ V
Sbjct: 364 RTV 366
>sp|Q17334|ADH1_CAEEL ALCOHOL DEHYDROGENASE K12G11.3 >gi|7505839|pir||T23626 probable
alcohol dehydrogenase (EC 1.1.1.1) K12G11.3 [similarity]
- Caenorhabditis elegans >gi|3878552|emb|CAB04604.1|
(Z81570) predicted using Genefinder~Similarity to Yeast
alcohol dehydrogenase (SW:P07246), contains similarity
to Pfam domain: PF00107 (Zinc-binding dehydrogenases),
Score=354.9, E-value=2.8e-103, N=1~cDNA EST EMBL:M88802
comes from this gene~cDNA EST >
Length = 349
Score = 113 bits (279), Expect = 4e-24
Identities = 90/286 (31%), Positives = 139/286 (48%), Gaps = 13/286 (4%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
E+ +V VP P E+L+K+ + IC +DLH+ W + P + GHE AG VV++G
Sbjct: 22 EVRQVPVPSPADDEILVKIEYSGICHSDLHV--WLGDLKDMSVCPLVGGHEGAGSVVQIG 79
Query: 78 PGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNV 136
V G ++GD V+ + C C C++G +C + + +G D G F EY + +
Sbjct: 80 KNVTGWQLGDKAGVKLMNFNCLNCEFCKKGHEPLCHHIQNYGFDRSGTFQEYLTIRGVDA 139
Query: 137 WKNPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGA-GPLGLLGIAVAKASGAY 193
K K A G V L + G+ +++TGA G LG L I A A G
Sbjct: 140 AKINKDTNLAAAAPILCAGVTVYKALKESNVAPGQIIVLTGAGGGLGSLAIQYACAMGMR 199
Query: 194 PVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQ 252
V + S + K +GA++ ++ FE D+V + +T+G G + F+ A K +EQ
Sbjct: 200 VVAMDHGS--KEAHCKGLGAEWFVDAFETPDIVSHITKLTEG-GPHGVINFAVARKPMEQ 256
Query: 253 GLQAVTPAGRVSLLGL-YPGKVSIDFNNLIIFKALTVYG-ITGRHL 296
++ V G V +GL KV+ D IF A+T+ G I G L
Sbjct: 257 AVEYVRKRGTVVFVGLPKDSKVTFD-TTPFIFNAITIKGSIVGSRL 301
>sp|P28469|ADH_MACMU ALCOHOL DEHYDROGENASE ALPHA CHAIN (ADH) >gi|2117437|pir||I55359
alcohol dehydrogenase (EC 1.1.1.1) 1 - rhesus macaque
>gi|342065|gb|AAA36830.1| (M81807) alcohol dehydrogenase
[Macaca mulatta]
Length = 375
Score = 112 bits (278), Expect = 5e-24
Identities = 103/358 (28%), Positives = 160/358 (43%), Gaps = 45/358 (12%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHEVAGEVVEVGPG 79
+V+V P EV IK++ ICGTD H+ + + + P P I+GHE AG V VG G
Sbjct: 26 DVEVAPPKAYEVRIKMVTVGICGTDDHVV-----SGTMVTPLPVILGHEAAGIVESVGEG 80
Query: 80 VEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GVDTDG------------- 123
V +E GD V CGKC C+ + + C + G DG
Sbjct: 81 VTTVEPGDKVIPLALPQCGKCRICKTPERNYCLKNDVSNPRGTLQDGTSRFTCRGKPIHH 140
Query: 124 -----VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLI 173
F++Y VV V K + P E L G+AV P G + +
Sbjct: 141 FLGVSTFSQYTVVDENAVAKIDAASPMEKVCLIGCGFSTGYGSAVKVAKVTP--GSTCAV 198
Query: 174 TGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEEDVVKEVMDI 231
G G +GL + KA+GA +I + + + AK++GA INP +++ + + + ++
Sbjct: 199 FGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEM 258
Query: 232 TDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKVSIDFNNLIIFKALT--- 287
TDG GVD E G + L A G ++G+ P ++ N +++ T
Sbjct: 259 TDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKG 317
Query: 288 -VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
VYG G E + + K +LD +ITH F+K E F+L+R+GK+ + +
Sbjct: 318 AVYG--GFKSKEDIPKLVADFMAKKFSLDALITHVLP-FEKINEGFDLLRSGKSIRTI 372
>gb|AAB66676.1| (U73654) alcohol dehydrogenase ADH-F [Gallus gallus]
Length = 376
Score = 112 bits (278), Expect = 5e-24
Identities = 101/357 (28%), Positives = 160/357 (44%), Gaps = 38/357 (10%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
E++V P EV +K++AT IC TD H+ E N + P I+GHE AG V +G GV
Sbjct: 26 EIEVAPPKAREVRVKMVATGICHTDEHVLEGNF---PDVDFPVILGHEGAGIVESIGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYH---------------------VCQNTKIFGV 119
++ GD V + CG+C C + C+ +I
Sbjct: 83 TSVKPGDKVILFPLPQCGECSFCLNPDSNYCLKSHLTEPQNLMPDKTTRFTCKGKQIQHF 142
Query: 120 DTDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLIT 174
+ FAEY VVP + K + P + + G AV+T A G + +
Sbjct: 143 LWNSTFAEYTVVPEYTLAKIDAAAPLDKVCVFACGFSTGYGAAVNT--AKVKLGSTCAVF 200
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMDITD 233
G G +GL + KA+GA +I + + + AK++GA INP + + +++V+
Sbjct: 201 GLGGVGLSVVMGCKAAGASRIIAIDINKDKFAKAKEMGATECINPQDFKKPIQQVLTEMT 260
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVT-PAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGIT 292
G+GVD E G L L + G ++G+ P ++ + ++ T G T
Sbjct: 261 GHGVDYSFEAIGTADTLIAALASCNMNTGVCVMVGVLPAGSTVPIDPFLLLSGRTCKG-T 319
Query: 293 GRHLWETWYTVSRLLQS---GKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFM 346
W+ ++ +L+ S K N D +ITH F K E FEL+RAGK+ + V +
Sbjct: 320 LAGGWKMRDSIPKLVASYLEKKFNSDLLITHTLP-FAKINEGFELLRAGKSIRTVML 375
>sp|O19053|ADHX_RABIT ALCOHOL DEHYDROGENASE CLASS III CHAIN (GLUTATHIONE-DEPENDENT
FORMALDEHYDE DEHYDROGENASE) (FDH) (FALDH)
>gi|2598605|emb|CAA75606.1| (Y15406) class III alcohol
dehydrogenase [Oryctolagus cuniculus]
Length = 374
Score = 112 bits (278), Expect = 5e-24
Identities = 107/356 (30%), Positives = 162/356 (45%), Gaps = 40/356 (11%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
E++V P EV IK+ AT++C TD + A P I+GHE AG V VG GV
Sbjct: 24 EIEVAPPKAHEVRIKIFATAVCHTDAYTLSG---ADPEGCFPVILGHEGAGIVESVGEGV 80
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GVDTDG-------------- 123
++ GD V CG+C C + ++CQ ++ G+ DG
Sbjct: 81 TNLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHY 140
Query: 124 ----VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLIT 174
F+EY VV +V K S P + L G A++T P G + +
Sbjct: 141 MGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAALNTAKVEP--GSTCAVF 198
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEEDVVKEVMDIT 232
G G +GL I KA+GA +I + + + AK+ GA INP F + + + +++ T
Sbjct: 199 GLGGVGLAAIMGCKAAGASRIIAVDINKDKFARAKEFGATECINPQDFSKPIQEVLVEKT 258
Query: 233 DGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFNNLIIFKALTVYGI 291
DG GVD E G K + L+A VS ++G+ I + T G
Sbjct: 259 DG-GVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAGAGEEISTRPFQLVTGRTWKG- 316
Query: 292 TGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
T W++ +V +L+ S K+N+D +T+ FD+ EAFELM +GK+ + V
Sbjct: 317 TAFGGWKSVESVPKLVSEYMSKKINVDEFVTNTL-SFDQINEAFELMHSGKSIRTV 371
>gb|AAF23556.1|AF110458_1 (AF110458) alcohol dehydrogenase [Barbarea vulgaris]
Length = 379
Score = 112 bits (278), Expect = 5e-24
Identities = 107/364 (29%), Positives = 166/364 (45%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP++ + + L + L A P G+SV + G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPEAPLDKVCIVSCGLSTGLGATLTVAKPKKGQSVAVFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL AK +GA +I + + R E AKK G +NP E D V + + D+T+
Sbjct: 203 LGAVGLGAAEGAKMAGASRIIGVDLNPKRFEEAKKFGVTEFVNPREHDKPVQQVIADMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEMYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>sp|P14139|ADH_PAPHA ALCOHOL DEHYDROGENASE (ADH) >gi|86651|pir||A33909 alcohol
dehydrogenase (EC 1.1.1.1) 2 - baboon
>gi|176564|gb|AAA35378.1| (M25035) alcohol dehydrogenase
(EC 1.1.1.1) [Papio hamadryas]
Length = 375
Score = 112 bits (277), Expect = 7e-24
Identities = 110/375 (29%), Positives = 164/375 (43%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 11 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICRTDDHVVSGN-----LVSPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACR--RGQYHV---------- 110
I+GHE AG V VG GV ++ GD V CGKC C+ G Y V
Sbjct: 64 AILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKSPEGNYCVKNDLSNPRGT 123
Query: 111 ---------CQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
C+ I F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCRGKPIHHFVGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVNVAKVTP--GSVCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ 300
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 301 NLSINPMLLLTGRTWKGAVYG--GFKSREGIPKLVADFMAKKFSLDALITHVLP-FEKIN 357
Query: 330 EAFELMRAGKTGKVV 344
E F+L+R+GK+ + V
Sbjct: 358 EGFDLLRSGKSIRTV 372
>gb|AAF23528.1|AF110430_1 (AF110430) alcohol dehydrogenase [Cardamine amara]
Length = 379
Score = 112 bits (277), Expect = 7e-24
Identities = 105/364 (28%), Positives = 167/364 (45%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVC----QNTKIFGVDTDGV------------ 124
++ GD+V CG C C + ++C +NT G+ DGV
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRKNTDRVGMIHDGVSRFSINGKPIHH 142
Query: 125 ------FAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY +V + V K NP++ + + L + L A P G+SV + G
Sbjct: 143 FLGTSTFSEYTMVHSGQVAKINPEAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAVFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ SGA +I + + R E AKK G +NP E D V + + ++T+
Sbjct: 203 LGAVGLAACEGARMSGASRIIGVDLNPKRFEEAKKFGVTEFVNPREHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + + +L ++ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEMYMNKELEIEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>emb|CAB62734.1| (AL133423) putative dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 338
Score = 111 bits (276), Expect = 9e-24
Identities = 95/331 (28%), Positives = 151/331 (44%), Gaps = 19/331 (5%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGP 78
LV + +PGPGE L++V A ICG+D +Y+ N + ++ P GHE +G V VG
Sbjct: 15 LVPHEPGEPGPGEALVRVHAAGICGSDREVYQGNR-PEGYVRYPLTPGHEWSGTVERVGA 73
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC-QNTKIFGVDTDGVFAEYAVVPAQNVW 137
GV G VG V E C C C G+ +C + G G A +PA+ +
Sbjct: 74 GVPGSLVGRKVVGEGFRNCQVCDRCHAGETTLCTAGYEETGFTQPGAMAPTLTLPARLLH 133
Query: 138 KNPKSIPPEYATLQEPLG-NAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVI 196
P A L EP A + A G+ V + G G LG+ + +A+ ++
Sbjct: 134 ALPDDADLTAAALLEPAACIAAAALKANARPGERVAVVGTGTLGMFAVQFLRAASPAELL 193
Query: 197 VSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQA 256
V R L+++ GA D + +TD DV +E +G+ A
Sbjct: 194 VVGTRGDREALSRQFGA--------TDFRTKDRPLTD--DFDVVIETAGSADAARTAAAL 243
Query: 257 VTPAGRVSLLGL-YPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLD 315
+ GR+ L G+ PG +D +L++ + L V+ + G + W R+ +G L+
Sbjct: 244 LRRGGRLVLTGIPAPGAGGLDPTDLVV-RQLEVHTVFGAPP-DAWAHTVRVFAAGLLDPR 301
Query: 316 PIITHKYKGFDKYEEAFELMRAG--KTGKVV 344
P++TH+ ++ EA EL+ +G K GKV+
Sbjct: 302 PLVTHELP-LAEFSEAIELVGSGDPKVGKVL 331
>gb|AAK42487.1| Alcohol dehydrogenase (Zn containing) (adh-6) [Sulfolobus
solfataricus]
Length = 338
Score = 111 bits (275), Expect = 1e-23
Identities = 97/334 (29%), Positives = 166/334 (49%), Gaps = 28/334 (8%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV P+ GP +VLI+V+ + + D + A P I G E+AG V +VG V
Sbjct: 25 EVQEPQLGPHDVLIRVVKSGLNPIDYFVIN----AIPVTPMPHIPGAELAGVVEKVGDHV 80
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNP 140
+G+ GD V V + G C C G+ +C+N I V T+G ++EY VP +N++K P
Sbjct: 81 KGLNKGDKVVVYNRVFDGTCDLCLSGREMLCRNGGIMSVITNGGWSEYFSVPDKNIFKIP 140
Query: 141 KSIPPEYATLQEPLG-----NAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPV 195
+S+ + A P+ +++ + GP + V+ +G GL + +AK GA +
Sbjct: 141 ESMSWDVAA-SLPVAALTSYHSLKELEVGP-NDIIVIFGASGNTGLFAVQLAKKFGATVI 198
Query: 196 IVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQ 255
VS R+ K+ GADY++ +DVV++V +IT+G DV + G+ E LQ
Sbjct: 199 AVS-----RKNWLKEFGADYIVG--YDDVVQKVKEITNGKMADVVINSLGS-SMWENSLQ 250
Query: 256 AVTPAGRVSLLGLYPG-KVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNL 314
+ G+++ G G +V ++ ++L + + V G TG E ++ L + K+ +
Sbjct: 251 VLGLDGQLAFFGTLTGSEVKVNLSSL-YGRHIKVVGTTGGSRKELMELIN-LCKDCKVKV 308
Query: 315 DPIITHK-YKGFDKYEEAFELMRAGKTGKVVFML 347
HK YK + E E+M + G+++ +
Sbjct: 309 -----HKTYKLDEGVEAVKEIMNENREGRIMLQV 337
>sp|P25437|ADH3_ECOLI ALCOHOL DEHYDROGENASE CLASS III (GLUTATHIONE-DEPENDENT FORMALDEHYDE
DEHYDROGENASE) (FDH) (FALDH) >gi|7427627|pir||D64763
alcohol dehydrogenase (EC 1.1.1.1) C - Escherichia coli
>gi|1786552|gb|AAC73459.1| (AE000142) alcohol
dehydrogenase class III; formaldehyde dehydrogenase,
glutathione-dependent [Escherichia coli K12]
>gi|2443392|dbj|BAA22412.1| (D38504) formaldehyde
dehydrogenase [Escherichia coli]
Length = 369
Score = 111 bits (275), Expect = 1e-23
Identities = 105/374 (28%), Positives = 171/374 (45%), Gaps = 42/374 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + P E+VE+DV P GEVLIKV T +C TD ++ P
Sbjct: 2 KSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDD---PEGVFPV 58
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFGVD 120
++GHE AG VVEVG GV ++ GD+V CG+C CR G+ ++C + T+ G+
Sbjct: 59 VLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLM 118
Query: 121 TDG------------------VFAEYAVVPAQNVWK-NPKSIPPEYATL----QEPLGNA 157
DG F+EY VV ++ K NP++ L +G
Sbjct: 119 PDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAV 178
Query: 158 VDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI 217
+T P G SV + G G +GL + A+ + A +I + + + +LA++ GA I
Sbjct: 179 HNTAKVQP--GDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCI 236
Query: 218 NPFEED-VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPG--KV 273
NP + D +K+V+ + G+D E G + L++ G+ ++G+ ++
Sbjct: 237 NPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAVAGQEI 296
Query: 274 SIDFNNLI---IFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEE 330
S L+ ++K G+ GR + G ++L+P +TH D+ +
Sbjct: 297 STRPFQLVTGRVWKGSAFGGVKGRSQLPGMVEDA---MKGDIDLEPFVTHT-MSLDEIND 352
Query: 331 AFELMRAGKTGKVV 344
AF+LM GK+ + V
Sbjct: 353 AFDLMHEGKSIRTV 366
>gi|11435477 alcohol dehydrogenase 2 (class I), beta polypeptide [Homo sapiens]
>gi|113394|sp|P00325|ADHB_HUMAN ALCOHOL DEHYDROGENASE
BETA CHAIN >gi|625195|pir||DEHUAB alcohol dehydrogenase
(EC 1.1.1.1) 2 [validated] - human
>gi|28416|emb|CAA27056.1| (X03350) ADH beta-1-subunit
(aa 1-375) [Homo sapiens] >gi|178111|gb|AAB59496.1|
(M24316) alcohol dehydrogenase beta-1 subunit [Homo
sapiens] >gi|219428|dbj|BAA00084.1| (D00137) alcohol
dehydrogenase beta 1 [Homo sapiens]
Length = 375
Score = 111 bits (274), Expect = 2e-23
Identities = 108/375 (28%), Positives = 165/375 (43%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 11 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICRTDDHVVSGN-----LVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 300
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 301 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 357
Query: 330 EAFELMRAGKTGKVV 344
E F+L+ +GK+ + V
Sbjct: 358 EGFDLLHSGKSIRTV 372
>pdb|1DEH|A Chain A, Crystallization Of Human Beta1 Alcohol Dehydrogenase (15
MgML) IN 50 MM SODIUM PHOSPHATE (PH 7.5), 2.0 MM NAD+
And 1 Mm 4-Iodopyrazole At 25 Oc, 13% (WV) PEG 8000
>gi|1421404|pdb|1DEH|B Chain B, Crystallization Of Human
Beta1 Alcohol Dehydrogenase (15 MgML) IN 50 MM SODIUM
PHOSPHATE (PH 7.5), 2.0 MM NAD+ And 1 Mm 4-Iodopyrazole
At 25 Oc, 13% (WV) PEG 8000 >gi|494087|pdb|1HDX|A Chain
A, Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-1
Isoenzyme, Human) Complexed With Nad(H) And Cyclohexanol
>gi|494088|pdb|1HDX|B Chain B, Alcohol Dehydrogenase
(E.C.1.1.1.1) (Beta-1 Isoenzyme, Human) Complexed With
Nad(H) And Cyclohexanol >gi|494876|pdb|3HUD|A Chain A,
Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-1 Isoenzyme)
>gi|494877|pdb|3HUD|B Chain B, Alcohol Dehydrogenase
(E.C.1.1.1.1) (Beta-1 Isoenzyme)
Length = 374
Score = 111 bits (274), Expect = 2e-23
Identities = 108/375 (28%), Positives = 165/375 (43%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 10 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICRTDDHVVSGN-----LVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 63 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 123 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 183 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 240
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 241 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 299
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 300 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 356
Query: 330 EAFELMRAGKTGKVV 344
E F+L+ +GK+ + V
Sbjct: 357 EGFDLLHSGKSIRTV 371
>pdb|1HDY|A Chain A, Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-2 Isoenzyme,
Human) Complexed With Nad+ And 4-Iodopyrazole
>gi|494090|pdb|1HDY|B Chain B, Alcohol Dehydrogenase
(E.C.1.1.1.1) (Beta-2 Isoenzyme, Human) Complexed With
Nad+ And 4-Iodopyrazole
Length = 374
Score = 111 bits (274), Expect = 2e-23
Identities = 108/375 (28%), Positives = 165/375 (43%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 10 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICHTDDHVVSGN-----LVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 63 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 123 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 183 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 240
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 241 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 299
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 300 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 356
Query: 330 EAFELMRAGKTGKVV 344
E F+L+ +GK+ + V
Sbjct: 357 EGFDLLHSGKSIRTV 371
>sp|P80468|ADH2_STRCA ALCOHOL DEHYDROGENASE II
Length = 379
Score = 111 bits (274), Expect = 2e-23
Identities = 104/368 (28%), Positives = 171/368 (46%), Gaps = 56/368 (15%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
E++V P EV +K++AT +C TD H N + + P I+GHE AG V +G GV
Sbjct: 25 EIEVSPPKDHEVRVKIVATGVCRTDEHAI--NPSFKEGVFPV-ILGHEGAGIVESIGQGV 81
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDT---------DGV------- 124
+ GD V CG C C + ++C+ KI + T DG
Sbjct: 82 SKFKPGDKVIPLYMPQCGHCKFCLNPKTNLCE--KISKIKTPISDQEVMSDGTSRFTCKG 139
Query: 125 -----------FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISG 168
F+EY VV ++ K + P + L G A++T P G
Sbjct: 140 KPIYHFMGTSTFSEYTVVSESSLAKIDAAAPLDKVCLIGCGFSTGYGAAINTAQVEP--G 197
Query: 169 KSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEV 228
+ + G G +GL + KA+GA + + + + LAKK+GA +NP +D+ K V
Sbjct: 198 STCAVFGLGGVGLSAVMGCKAAGASKIFGIDINKDKFPLAKKLGATDCLNP--QDIRKPV 255
Query: 229 MDI----TDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKVSIDFN--NLI 281
+I T+G GVD +E G P ++ ++ T G ++G+ G+ SI F+ LI
Sbjct: 256 QEIIAEMTNG-GVDFAIECIGNPDVMKAAFESTTVGWGTCVIVGVAVGEQSIPFSPMQLI 314
Query: 282 IFKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAG 338
+ + + G W++ +V +L+ + K +LD +++H DK +AF+LM AG
Sbjct: 315 MGRKIKATFFGG---WKSVKSVPKLVSDYMAKKFDLDALVSHTLP-LDKINDAFDLMNAG 370
Query: 339 KTGKVVFM 346
K+ + + +
Sbjct: 371 KSNRTILV 378
>gb|AAD37446.1| (AF153821) alcohol dehydrogenase beta2 subunit [Homo sapiens]
Length = 375
Score = 111 bits (274), Expect = 2e-23
Identities = 108/375 (28%), Positives = 165/375 (43%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 11 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICHTDDHVVSGN-----LVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 300
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 301 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 357
Query: 330 EAFELMRAGKTGKVV 344
E F+L+ +GK+ + V
Sbjct: 358 EGFDLLHSGKSIRTV 372
>sp|P73138|ADH3_SYNY3 PROBABLE ALCOHOL DEHYDROGENASE CLASS III (GLUTATHIONE-DEPENDENT
FORMALDEHYDE DEHYDROGENASE) (FDH) (FALDH)
>gi|7427628|pir||S75250 alcohol dehydrogenase (EC
1.1.1.1) sll0990 - Synechocystis sp. (strain PCC 6803)
>gi|1652241|dbj|BAA17164.1| (D90904) formaldehyde
dehydrogenase [Synechocystis sp.]
Length = 369
Score = 110 bits (273), Expect = 2e-23
Identities = 107/372 (28%), Positives = 166/372 (43%), Gaps = 45/372 (12%)
Query: 2 SEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP 61
S VA KP ++VE+DV P GEVL+K+ T +C TD ++
Sbjct: 3 SRAAVAFEVGKPL---QIVEIDVAPPQQGEVLVKITHTGVCHTDAFTLSGDD---PEGLF 56
Query: 62 PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFG 118
P ++GHE AG VVEVG GV +++GD+V CGKC CR G+ ++C + T+ G
Sbjct: 57 PVVLGHEGAGIVVEVGEGVTSVQLGDHVIPLYTAECGKCLFCRSGKTNLCVAVRATQGKG 116
Query: 119 VDTDG------------------VFAEYAVVPAQNVWK-NPKSIPPEYATL----QEPLG 155
V DG F+EY VV ++ K NP++ L +G
Sbjct: 117 VMPDGTSRFSYNGQSLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIG 176
Query: 156 NAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADY 215
+T P G SV + G G +GL + A+ + A +I + + + ELAK++GA
Sbjct: 177 AVHNTAKVQP--GDSVAVFGLGGIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQMGATD 234
Query: 216 VINPFEED-VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP + D +++V+ G GVD E G + + L+ G+ ++G+
Sbjct: 235 CINPKDHDQPIQQVIVEMTGWGVDHSFECIGNVEVMRSALECAHRGWGQSVIIGVAGAGQ 294
Query: 274 SIDFNNLII-----FKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKY 328
I + + G+ GR S G++ L P +TH + D
Sbjct: 295 EISTRPFQLVTGRKWMGTAFGGVKGRSQLPGMVEQS---MRGEIQLAPFVTHTMELKD-I 350
Query: 329 EEAFELMRAGKT 340
+AF+LM GK+
Sbjct: 351 NQAFDLMHDGKS 362
>gb|AAF23539.1|AF110441_1 (AF110441) alcohol dehydrogenase [Halimolobos perplexa var.
lemhiensis]
Length = 379
Score = 110 bits (273), Expect = 2e-23
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPVFTGECGDCRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV + G
Sbjct: 143 FVGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAVFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AKK G +NP + D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGIDLNPKRFDEAKKFGVTEFVNPKDHDKPVQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD LE +G +A+ Q + V V++L P K FK+ + +
Sbjct: 263 G-GVDRSLECTGNVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKSHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ + + + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGIVEMYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAF23549.1|AF110451_1 (AF110451) alcohol dehydrogenase [Arabis pauciflora]
Length = 379
Score = 110 bits (273), Expect = 2e-23
Identities = 107/364 (29%), Positives = 163/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I HE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFSHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAILG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R E AKK G +NP E D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGAARIIGVDLNPKRFEEAKKFGVTEFVNPREHDKPVQEVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD LE +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSLECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>sp|P09347|FDEH_PSEPU 5-EXO-ALCOHOL DEHYDROGENASE (FDEH) >gi|473746|dbj|BAA03511.1|
(D14680) 5-exo-hydroxycamphor dehydrogenase [Pseudomonas
putida]
Length = 361
Score = 110 bits (272), Expect = 3e-23
Identities = 102/351 (29%), Positives = 166/351 (47%), Gaps = 34/351 (9%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
E EV + P PG L++V+ +CG+D+HI A P I+GHE G + ++G
Sbjct: 16 ETWEVPIFDPAPGGALVRVVLGGVCGSDVHIVSGEAGAMPF---PIILGHEGIGRIEKLG 72
Query: 78 PGVE----GIEV--GDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD---GVFAEY 128
GV G+ V GD V +C +C++C N+ F G +A++
Sbjct: 73 TGVTTDYAGVPVKQGDMVYWAPIALCHRCHSCTVLDETPWDNSTFFEHAQKPNWGSYADF 132
Query: 129 AVVP-AQNVWKNPKSIPPEYATLQEPLGNAVDTVL-----AGPIS-GKSVLITGAGPLGL 181
A +P ++ P PE LG A+ TVL GP+ +V++ GAGP+GL
Sbjct: 133 ACLPNGMAFYRLPDHAQPEALAA---LGCALPTVLRGYDRCGPVGLDDTVVVQGAGPVGL 189
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE---EDVVKEVMDITDGNGVD 238
+ VA ASGA +I + S R ++A+ +GA I+ + E+ + V + G
Sbjct: 190 AAVLVAAASGAKDIIAIDHSPIRLDMARSLGATETISLADTTPEERQRIVQERFGKRGAS 249
Query: 239 VFLEFSGAPKALEQGLQAVTPAGRVSLLGLYP--GKVSIDFNNLIIFKALTVYGIT---G 293
+ +E +GA A +G+ GR +LGL+ G I +L I K +++ G T
Sbjct: 250 LVVEAAGALPAFPEGVNLTGNHGRYVILGLWGAIGTQPISPRDLTI-KNMSIAGATFPKP 308
Query: 294 RHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
+H ++ +RL + L +IT ++ D+ +A EL++AG K V
Sbjct: 309 KHYYQAMQLAARL--QDRYPLADLITQRF-SIDEASKALELVKAGALIKPV 356
>gb|AAB48003.1| (L38290) alcohol dehydrogenase beta-3 subunit [Homo sapiens]
Length = 375
Score = 110 bits (272), Expect = 3e-23
Identities = 107/371 (28%), Positives = 163/371 (43%), Gaps = 47/371 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 11 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICRTDDHVVSGN-----LVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 300
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 301 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 357
Query: 330 EAFELMRAGKT 340
E F+L+ +GK+
Sbjct: 358 EGFDLLHSGKS 368
>sp|P44557|ADH3_HAEIN PUTATIVE ALCOHOL DEHYDROGENASE CLASS III (GLUTATHIONE-DEPENDENT
FORMALDEHYDE DEHYDROGENASE) (FDH) (FALDH)
>gi|1074149|pir||H64052 alcohol dehydrogenase (EC
1.1.1.1) HI0185 - Haemophilus influenzae (strain Rd
KW20) >gi|1573141|gb|AAC21854.1| (U32703) alcohol
dehydrogenase, class III (adhC) [Haemophilus influenzae
Rd]
Length = 378
Score = 110 bits (272), Expect = 3e-23
Identities = 104/372 (27%), Positives = 166/372 (43%), Gaps = 38/372 (10%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + P ++VE+DV P GEVLI+ T +C TD ++ P
Sbjct: 11 KSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSD---PEGVFPV 67
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC------------ 111
++GHE AG VV VG GV ++ GD+V CG+C CR G+ ++C
Sbjct: 68 VLGHEGAGVVVAVGEGVLSVKPGDHVIPLYTAECGECEFCRSGKTNLCVSVRDTQGKGLM 127
Query: 112 ---------QNTKIFGVDTDGVFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTV 161
Q I+ F+EY+VV ++ K NP++ + L + + V
Sbjct: 128 PDCTTRFSYQGQPIYHYMGCSTFSEYSVVAEVSLAKINPEANHEQVCLLGCGVTTGIGAV 187
Query: 162 --LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP 219
A G SV + G G +GL + A+ + A +I + + + ELAK+ GA +NP
Sbjct: 188 HNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFGATDCLNP 247
Query: 220 FEED-VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPG--KVSI 275
+ D +K+V+ + G+D E G + Q L++ G+ ++G+ ++S
Sbjct: 248 NDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEIST 307
Query: 276 DFNNLI---IFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAF 332
L+ ++K G+ GR S G + L+P +TH DK EAF
Sbjct: 308 RPFQLVTGRVWKGSAFGGVKGRSELPQMVEDS---MKGDIQLEPFVTHTMP-LDKINEAF 363
Query: 333 ELMRAGKTGKVV 344
ELM GK+ + V
Sbjct: 364 ELMHEGKSIRTV 375
>pdb|1HTB|A Chain A, Crystallization Of Human Beta3 Alcohol Dehydrogenase (10
MgML) IN 100 MM SODIUM PHOSPHATE (PH 7.5), 7.5 MM Nad+
And 1 Mm 4-Iodopyrazole At 25 C >gi|1311011|pdb|1HTB|B
Chain B, Crystallization Of Human Beta3 Alcohol
Dehydrogenase (10 MgML) IN 100 MM SODIUM PHOSPHATE (PH
7.5), 7.5 MM Nad+ And 1 Mm 4-Iodopyrazole At 25 C
Length = 374
Score = 110 bits (272), Expect = 3e-23
Identities = 107/371 (28%), Positives = 163/371 (43%), Gaps = 47/371 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 10 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICRTDDHVVSGN-----LVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 63 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 123 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 183 AVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 240
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 241 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 299
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 300 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 356
Query: 330 EAFELMRAGKT 340
E F+L+ +GK+
Sbjct: 357 EGFDLLHSGKS 367
>gb|AAD38247.1|AC006193_3 (AC006193) very similar to alcohol dehydrogenase [Arabidopsis
thaliana]
Length = 387
Score = 110 bits (272), Expect = 3e-23
Identities = 111/380 (29%), Positives = 175/380 (45%), Gaps = 53/380 (13%)
Query: 6 VAIMKTKPAYGAE----LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP 61
V K A+GA + +V V P EV I+++ TSIC TDL ++ AQ
Sbjct: 7 VITCKAAVAWGAGEPLVMEDVKVDPPQRLEVRIRILFTSICHTDLSAWKGENEAQRAY-- 64
Query: 62 PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVD- 120
P+I+GHE AG V VG GVE + GD+V CG C C+R ++C+ ++ +
Sbjct: 65 PRILGHEAAGIVESVGEGVEEMMAGDHVLPIFTGECGDCRVCKRDGANLCERFRVDPMKK 124
Query: 121 ---TDG--------------------VFAEYAVVPAQNVWKNPKSIPPEYATL------- 150
TDG F+EY V+ + V K P E +L
Sbjct: 125 VMVTDGKTRFFTSKDNKPIYHFLNTSTFSEYTVIDSACVLKVDPLFPLEKISLLSCGVST 184
Query: 151 -----QEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRR 205
E +G A + P S +V I G G +GL A+A GA +I + + +
Sbjct: 185 DKCLWNEGVGAAWNVADIQPAS--TVAIFGLGAVGLAVAEGARARGASKIIGIDINPDKF 242
Query: 206 ELAKKVGADYVINPFEED--VVKEVMDITDGNGVDVFLEFSGAPKALEQG-LQAVTPAGR 262
+L ++ G INP E D V + VM+IT+G GV+ E +G+ +AL + L + G
Sbjct: 243 QLGREAGISEFINPKESDKAVHERVMEITEG-GVEYSFECAGSIEALREAFLSTNSGVGV 301
Query: 263 VSLLGLYPGKVSIDFNNLIIFKALTV-YGITGRHLWETW--YTVSRLLQSGKLNLDPIIT 319
+LG++ + + + +F+ ++ + G +T + +++ LQ G LNLD I+
Sbjct: 302 TVMLGVHASPQLLPIHPMELFQGRSITASVFGGFKPKTQLPFFITQCLQ-GLLNLDLFIS 360
Query: 320 HKYKGFDKYEEAFELMRAGK 339
H+ F EA +L+ GK
Sbjct: 361 HQLP-FHDINEAMQLLHQGK 379
>pir||B83373 probable alcohol dehydrogenase (Zn-dependent) PA2188 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9948209|gb|AAG05576.1|AE004645_10 (AE004645)
probable alcohol dehydrogenase (Zn-dependent)
[Pseudomonas aeruginosa]
Length = 388
Score = 110 bits (272), Expect = 3e-23
Identities = 107/380 (28%), Positives = 164/380 (43%), Gaps = 61/380 (16%)
Query: 9 MKTKPAYGAELVEVD-VPKPG---PGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M+ +G+ V +D V +P P ++L++V AT+ICG+DLH+Y ++ I
Sbjct: 1 MRALTFHGSHDVRIDRVAEPRLQEPDDLLLRVTATAICGSDLHLYRGKI---PMVEQGDI 57
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTK--------- 115
+GHE G V EVG V + GD V V I CG+C+ CR + C+ T
Sbjct: 58 LGHEFMGVVEEVGSAVTAVRPGDRVVVPFVIACGECFFCRLNLHAACETTNPGRGAILNK 117
Query: 116 --------IFGVD-----TDGVFAEYAVVPAQNVWKNPKSIP-----PEYATLQEPLGNA 157
++G G AEY VP N P IP L + L
Sbjct: 118 KQIPPGAALYGYSHLYGGVPGGQAEYVRVPKAN--SGPFVIPDVMEDERVLFLSDILSTG 175
Query: 158 VDTVL-AGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKV-GADY 215
V AG G SV I GAGP+GL+ A A+ GA + + + +R + A + GA
Sbjct: 176 YQAVRNAGVRQGSSVAIYGAGPVGLMAAACARMLGAERIFIVDHHPYRLDFAARTYGAIP 235
Query: 216 VINPFEEDVVKEVMDITDGN-GVDVFLEFSG--------------------APKALEQGL 254
+ E+D +++ TDG+ GVD ++ G + KAL Q +
Sbjct: 236 IDFDQEDDPAAAIIERTDGHRGVDAVIDAVGFEAKGSVTETVLTALKLEASSGKALRQCI 295
Query: 255 QAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNL 314
AV G VS+ G+Y G + K LT + + H+ + + +G L+
Sbjct: 296 AAVRRGGTVSVPGVYAGFIHGFLFGDAFDKGLT-FKMGQTHVQALLPALLEHIGNGDLHP 354
Query: 315 DPIITHKYKGFDKYEEAFEL 334
+ II+H+ + D E + L
Sbjct: 355 EAIISHRLR-LDDAPEGYAL 373
>sp|P19631|ADH3_COTJA ALCOHOL DEHYDROGENASE ALPHA CHAIN (ADH3) >gi|86146|pir||A35837
alcohol dehydrogenase (EC 1.1.1.1) I - Japanese quail
Length = 375
Score = 109 bits (271), Expect = 4e-23
Identities = 105/362 (29%), Positives = 160/362 (44%), Gaps = 42/362 (11%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGP 78
L EV+V P EV IK++AT IC +D H+ + P I+GHE AG V VG
Sbjct: 23 LEEVEVAPPKAHEVRIKIVATGICRSDDHVVT----GALAMPFPVILGHEAAGVVESVGE 78
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI----FGVDTDG----------- 123
V ++ GD V CG+C +C + ++C + G+ DG
Sbjct: 79 KVTLLKPGDAVIPLFVPQCGECRSCLSTKGNLCIKNDLSSSPTGLMADGTTRFTCKGKAI 138
Query: 124 -------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSV 171
F EY VV K + P E L G + T P G +
Sbjct: 139 HHFIGTSTFTEYTVVHETAAAKIDSAAPLEKVCLIGCGFSTGYGAVLQTAKVEP--GSTC 196
Query: 172 LITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMD 230
+ G G +GL + KA+GA +I + + + AK++GA +NP + + + EV+
Sbjct: 197 AVFGLGGVGLSVVMGCKAAGASRIIAIDINKDKFAKAKELGATECVNPKDFKKPIHEVLT 256
Query: 231 ITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFNNLIIFKALTVY 289
G GVD E G + + + L + VS ++G+ P I F+ ++IF T
Sbjct: 257 EMTGKGVDYSFEVIGRIETMTEALASCHYNYGVSVIVGVPPAAQKISFDPMLIFSGRTWK 316
Query: 290 G-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
G + G W++ V +L+ K LDP+ITH F K E F+L+R GK+ + V
Sbjct: 317 GSVFGG--WKSKDAVPKLVADYMKKKFVLDPLITHTLP-FTKINEGFDLLRTGKSIRTVL 373
Query: 346 ML 347
+L
Sbjct: 374 VL 375
>sp|P43067|ADH1_CANAL ALCOHOL DEHYDROGENASE 1 (40 KD ALLERGEN) (ALLERGEN CAN A 1) (CAN A
I) >gi|1076931|pir||S52153 alcohol dehydrogenase (EC
1.1.1.1) - yeast (Candida albicans)
>gi|2131134|pir||S63781 alcohol dehydrogenase (EC
1.1.1.1) - yeast (Candida albicans)
>gi|608690|emb|CAA57342.1| (X81694) alcohol
dehydrogenase [Candida albicans]
Length = 350
Score = 109 bits (271), Expect = 4e-23
Identities = 105/332 (31%), Positives = 158/332 (46%), Gaps = 18/332 (5%)
Query: 16 GAELVEVD--VPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEV 73
G +LV D VP P P E+LI V + +C TDLH + +W + K P + GHE AG V
Sbjct: 18 GGQLVYKDYPVPTPKPNELLIHVKYSGVCHTDLHARK-GDWPLAT-KLPLVGGHEGAGVV 75
Query: 74 VEVGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVP 132
V +G V+G ++GD+ ++ + C C C++G C + G DG F +YA
Sbjct: 76 VGMGENVKGWKIGDFAGIKWLNGSCMSCEFCQQGAEPNCGEADLSGYTHDGSFEQYATAD 135
Query: 133 AQNVWKNPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGAGP-LGLLGIAVAKA 189
A K P G V L A +G+ V I+GAG LG L + A+A
Sbjct: 136 AVQAAKIPAGTDLANVAPILCAGVTVYKALKTADLAAGQWVAISGAGGGLGSLAVQYARA 195
Query: 190 SGAYPVIVSEPSDFRRELAKKVGAD-YVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPK 248
G V+ + D + E K +GA+ YV ++D+V+ V TDG G + S + K
Sbjct: 196 MGLR-VVAIDGGDEKGEFVKSLGAEAYVDFTKDKDIVEAVKKATDG-GPHGAINVSVSEK 253
Query: 249 ALEQGLQAVTPAGRVSLLGL-YPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLL 307
A++Q ++ V P G+V L+GL KV+ + ++ K++ + G + +T +
Sbjct: 254 AIDQSVEYVRPLGKVVLVGLPAHAKVTAPVFDAVV-KSIEIKGSYVGNRKDTAEAID--F 310
Query: 308 QSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
S L PI K G E F+LM GK
Sbjct: 311 FSRGLIKCPI---KIVGLSDLPEVFKLMEEGK 339
>gb|AAG20655.1| (AE005134) alcohol dehydrogenase; Adh2 [Halobacterium sp. NRC-1]
Length = 347
Score = 109 bits (271), Expect = 4e-23
Identities = 75/264 (28%), Positives = 125/264 (46%), Gaps = 18/264 (6%)
Query: 18 ELVEVDVPKP---GPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVV 74
E+ +VPKP P + +I+V T++CG+DL Y + ++ + +GHE G V
Sbjct: 11 EIAVEEVPKPDIESPEDAVIRVTHTAVCGSDLWFYRGDSDREAGSR----VGHEPMGIVE 66
Query: 75 EVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDG---------VF 125
EVG V + GD V I CG+C CR+G Y C + +G + +G F
Sbjct: 67 EVGDDVTSVAPGDRVIAPFAISCGECEFCRQGLYTSCVEDESWGSEANGGGQGEYVKCPF 126
Query: 126 AEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVD-TVLAGPISGKSVLITGAGPLGLLGI 184
A+ +V + + + + + L + +G V AG G + ++ G G +GL G+
Sbjct: 127 ADGTLVRVPDRYADDEDVLESLLPLTDVMGTGHHAAVSAGVGEGDTAVVVGDGAVGLCGV 186
Query: 185 AVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFS 244
A+ GA +I + R ELA + GA I+ +D ++ D+T G G + +E
Sbjct: 187 LAAQRLGAERIIAMGHHEDRLELAAEFGATDTISARGDDAIERARDLTHG-GANHVMECV 245
Query: 245 GAPKALEQGLQAVTPAGRVSLLGL 268
GA A++ + P G V +G+
Sbjct: 246 GAASAMDSAIAIARPGGTVGYVGV 269
>sp|P80338|ADH1_STRCA ALCOHOL DEHYDROGENASE I >gi|1079371|pir||S48157 alcohol
dehydrogenase (EC 1.1.1.1) I - ostrich
Length = 374
Score = 109 bits (270), Expect = 5e-23
Identities = 108/377 (28%), Positives = 171/377 (44%), Gaps = 45/377 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K A + +P + EV+V P EV +K+IAT IC +D H+ + + P P
Sbjct: 8 KCKAAVLWEPKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVI-----SGVLVMPFP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CG+C C + ++C+ I +
Sbjct: 63 IILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECSVCLSTKGNLCRKNDIGPASAL 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F EY V+ V K + P E L G
Sbjct: 123 MPDGTSRFTCKGKAIHHFAGTSTFTEYTVLHETAVAKIDAAAPLEKVCLIGCGFSTGYGA 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
A+ T P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 183 ALQTAKVEP--GSTCAVFGLGGVGLSVVMGCKAAGASRIIGVDINKDKFAKAKELGATDC 240
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKV 273
+NP F + + + +M++T G GVD E G + + L + VS ++G+ P
Sbjct: 241 VNPKDFTKPIHEVLMEMT-GLGVDYSFEVIGHTETMAAALASCHFNYGVSVIVGVPPAAE 299
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
+ F+ +++F T G + G W++ +V +L+ K LDP+ITH F K
Sbjct: 300 KLSFDPMLLFSGRTWKGSVFGG--WKSKDSVPKLVADYMEKKFVLDPLITHTLP-FHKIN 356
Query: 330 EAFELMRAGKTGKVVFM 346
E F+L+R GK+ + V +
Sbjct: 357 EGFDLLRTGKSIRSVLL 373
>pir||S57525 alcohol dehydrogenase (EC 1.1.1.1) C - Escherichia coli (isolate
VU 3685) >gi|887431|emb|CAA52057.1| (X73835)
formaldehyde dehydrogenase (glutathione) [Escherichia
coli]
Length = 369
Score = 109 bits (270), Expect = 5e-23
Identities = 103/374 (27%), Positives = 170/374 (44%), Gaps = 42/374 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + P E+VE+DV P GEVL+K+ T +C TD ++ P
Sbjct: 2 KSRAAVAFAPGKPLEIVEIDVEPPRKGEVLVKITHTGVCHTDAFTLSGDD---PEGVFPA 58
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFGVD 120
++GHE AG VVEVG GV ++ GD+V CG+C C+ G+ ++C + T+ G+
Sbjct: 59 VLGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECLFCKSGKTNLCVSVRATQGKGLM 118
Query: 121 TDG------------------VFAEYAVVPAQNVWK-NPKSIPPEYATL----QEPLGNA 157
DG F+EY VV ++ K NP++ L +G
Sbjct: 119 PDGTTRFSYKGQPLFHYMGCSTFSEYTVVAEVSLAKINPQANHEHVCLLGCGVTTGIGAV 178
Query: 158 VDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI 217
+T P G +V I G G +GL + A+ + A + + + + +LA+ GA I
Sbjct: 179 HNTAKVQP--GDTVAIFGLGGIGLAAVQGARQAKAGRIFAIDTNPEKFDLARSFGATDCI 236
Query: 218 NPFEED-VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPG--KV 273
NP + D +++V+ G GVD E G + L+A G+ ++G+ ++
Sbjct: 237 NPKDYDKPIQDVLIELTGWGVDHTFECIGNVNVMRSALEAAHRGWGQSVVIGVAGAGKEI 296
Query: 274 SIDFNNLI---IFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEE 330
S L+ ++K G+ GR + G+++L P +TH G ++ +
Sbjct: 297 STRPFQLVTGRVWKGSAFGGVKGRTQLPGMVEDA---MKGEIDLAPFVTHT-MGLEEIND 352
Query: 331 AFELMRAGKTGKVV 344
AF+LM GK+ + V
Sbjct: 353 AFDLMHEGKSIRTV 366
>dbj|BAA22972.1| (D63453) alcohol dehydrogenase [Arabis gemmifera]
Length = 379
Score = 109 bits (270), Expect = 5e-23
Identities = 104/364 (28%), Positives = 164/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
+ GD+V CG C C + H+C NT+ G+ DG
Sbjct: 83 TDLHPGDHVLPIFTGECGDCPHCHSEESHMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSQRFDQAKEFGVTEFVNPRDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q ++ V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAIECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVEEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>pir||T18230 alcohol dehydrogenase (EC 1.1.1.1) II - yeast (Candida albicans)
>gi|3859714|emb|CAA21988.1| (AL033501) alcohol
dehydrogenase II [Candida albicans]
Length = 348
Score = 109 bits (270), Expect = 5e-23
Identities = 104/337 (30%), Positives = 156/337 (45%), Gaps = 34/337 (10%)
Query: 18 ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVG 77
E ++ VPKP E+LI V + +C TDLH ++ +W + K P + GHE AG VV +G
Sbjct: 20 EYKDIPVPKPKANELLINVKYSGVCHTDLHAWK-GDWPLAT-KLPLVGGHEGAGVVVALG 77
Query: 78 PGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNV 136
V+G +VGDY V+ + C C C+ G C + G DG F +YA A
Sbjct: 78 ENVKGWKVGDYAGVKWLNGSCLNCEYCQSGAEPNCAEADLSGYTHDGSFQQYATADAVQA 137
Query: 137 WKNPKSIPPEYATLQEPLGNAVDTVLAGPI-----------SGKSVLITG-AGPLGLLGI 184
+ P L N + AG +G+ V I+G AG LG L +
Sbjct: 138 ARIPAG---------TDLANVAPILCAGVTVYKALKTAELEAGQWVAISGAAGGLGSLAV 188
Query: 185 AVAKASGAYPVIVSEPSDFRRELAKKVGADYVIN-PFEEDVVKEVMDITDGNGVDVFLEF 243
AKA G Y V+ + + + E K +GA+ I+ E+DVV+ V T+G G +
Sbjct: 189 QYAKAMG-YRVLAIDGGEDKGEFVKSLGAETFIDFTKEKDVVEAVKKATNG-GPHGVINV 246
Query: 244 SGAPKALEQGLQAVTPAGRVSLLGLYPG-KVSIDFNNLIIFKALTVYGITGRHLWETWYT 302
S + +A+ Q + V G+V L+GL G K+S + +I K + + G + +T
Sbjct: 247 SVSERAIGQSTEYVRTLGKVVLVGLPAGAKISTPVFDAVI-KTIQIKGSYVGNRKDTAEA 305
Query: 303 VSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGK 339
V + L PI K G + E ++LM GK
Sbjct: 306 VDFFTRG--LIKCPI---KIVGLSELPEVYKLMEEGK 337
>sp|P45382|FADH_PARDE GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE (FDH) (FALDH)
(GD-FALDH) >gi|548208|gb|AAA65962.1| (L36327)
glutathione-dependent formaldehyde dehydrogenase
[Paracoccus denitrificans] >gi|1002865|gb|AAC44551.1|
(U34346) NAD-GSH-dependent formaldehyde dehydrogenase
[Paracoccus denitrificans]
Length = 375
Score = 109 bits (269), Expect = 6e-23
Identities = 105/388 (27%), Positives = 172/388 (44%), Gaps = 67/388 (17%)
Query: 6 VAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP---- 61
VA+ KP E++EV++ P GEV++++ AT IC TD E+ S P
Sbjct: 7 VALEAGKPL---EVMEVNLEGPKAGEVMVEIKATGICHTD-------EFTLSGADPEGLF 56
Query: 62 PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---------- 111
P I+GHE AG VVEVGPGV ++ G++V C +C +C G+ ++C
Sbjct: 57 PSILGHEGAGVVVEVGPGVTSVKPGNHVIPLYTPECRQCASCLSGKTNLCTAIRATQGQG 116
Query: 112 ------------QNTKIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVD 159
T IF F+ Y V+P V K + P + +G V
Sbjct: 117 LMPDGTSRFSMLDGTPIFHYMGCSTFSNYTVLPEIAVAKVREDAPFDKICY---IGCGVT 173
Query: 160 TVLAGPIS------GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGA 213
T + I+ G ++ G G +GL + + +GA +I + +D ++ +A+ G
Sbjct: 174 TGIGAVINTAKVEIGAKAVVFGLGGIGLNVLQGLRLAGADMIIGVDLNDDKKPMAEHFGM 233
Query: 214 DYVINPFE-EDVVKEVMDITDG-----NGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLL 266
+ INP E+VV+E++++T G D + +G K + L+ G+ ++
Sbjct: 234 THFINPKNCENVVQEIVNLTKTPFDQIGGADYSFDCTGNVKVMRDALECTHRGWGQSIII 293
Query: 267 GLYPGKVSIDFN--NLI---IFKALTVYGITGR---HLWETWYTVSRLLQSGKLNLDPII 318
G+ P I L+ ++K G GR WY GK+ +DP+I
Sbjct: 294 GVAPAGAEISTRPFQLVTGRVWKGTAFGGARGRTDVPQIVDWY------MDGKIEIDPMI 347
Query: 319 THKYKGFDKYEEAFELMRAGKTGKVVFM 346
TH D + F+LM AG++ + V +
Sbjct: 348 THTL-SLDDINKGFDLMHAGESIRSVVL 374
>emb|CAA33487.1| (X15447) alcohol dehydrogenase [Homo sapiens]
Length = 376
Score = 108 bits (267), Expect = 1e-22
Identities = 108/375 (28%), Positives = 165/375 (43%), Gaps = 46/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC TD H+ N + P P
Sbjct: 11 KAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICHTDDHVVSGN-----LVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV+ V G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVN-VAKVVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 242
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 243 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ 301
Query: 274 SIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T VYG G E + + K +LD +ITH F+K
Sbjct: 302 NLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FEKIN 358
Query: 330 EAFELMRAGKTGKVV 344
E F+L+ +GK+ + V
Sbjct: 359 EGFDLLHSGKSIRTV 373
>gb|AAF18534.1|AC006551_20 (AC006551) Very similar to alcohol dehydrogenase [Arabidopsis
thaliana]
Length = 388
Score = 108 bits (267), Expect = 1e-22
Identities = 98/360 (27%), Positives = 161/360 (44%), Gaps = 38/360 (10%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
++ V P EV IK++ TS+C TDL ++ + SR P+I+GHE G V +G V
Sbjct: 32 DIHVDPPQAYEVRIKILCTSLCHTDLTFWKLSFGPISRF--PRILGHEAVGVVESIGENV 89
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVC--------QNTKIFGV-----DTDG---- 123
+G + GD V H C +C C+ + + C NT+ +G+ D+ G
Sbjct: 90 DGFKQGDVVLPVFHPYCEECKDCKSSKTNWCDRYAEDFISNTRRYGMASRFKDSSGEVIH 149
Query: 124 ------VFAEYAVVPAQNVWKNPKSIPPEYATLQE---PLGNAVDTVLAGPISGKSVLIT 174
F+EY VV ++ K IP + A L G +A G ++ I
Sbjct: 150 HFLFVSSFSEYTVVDIAHLVKISPEIPVDKAALLSCGVSTGIGAAWKVANVEEGSTIAIF 209
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPF---EEDVVKEVMDI 231
G G +GL A+ GA +I + + + EL KK G INP E+ + + + ++
Sbjct: 210 GLGAVGLAVAEGARLRGAAKIIGIDTNSDKFELGKKFGFTDFINPTLCGEKKISEVIKEM 269
Query: 232 TDGNGVDVFLEFSGAPKALEQG-LQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYG 290
T+G GVD E G L + + T G+ +LG+ I + + + + G
Sbjct: 270 TEG-GVDYSFECVGLASLLNEAFISTRTGTGKTVMLGMEKHAAPISLGSFDLLRGRVICG 328
Query: 291 -ITG--RHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
+ G + + V L+ +LNLD ITH+ F + +AF L+ GK+ + + +
Sbjct: 329 SLFGGLKSKLDIPILVDHYLKK-ELNLDSFITHEL-NFKEINKAFALLEEGKSLRCILWM 386
>sp|P00327|ADHE_HORSE ALCOHOL DEHYDROGENASE E CHAIN >gi|625197|pir||DEHOAL alcohol
dehydrogenase (EC 1.1.1.1) E - horse
>gi|164176|gb|AAA30931.1| (M64864) alcohol
dehydrogenase-E-isoenzyme [Equus caballus]
Length = 375
Score = 108 bits (266), Expect = 1e-22
Identities = 107/374 (28%), Positives = 169/374 (44%), Gaps = 45/374 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++AT IC +D H+ + + + P P
Sbjct: 11 KAAVLWEEKKPFSIEEVEVAPPKAH--EVRIKMVATGICRSDDHVV-----SGTLVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I GHE AG V +G GV + GD V CGKC C+ + + C + G
Sbjct: 64 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV +V K + P E L G+
Sbjct: 124 MQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV +A G + + G G +GL I KA+GA +I + + + AK+VGA
Sbjct: 184 AVK--VAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 241
Query: 217 INPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVS 274
+NP + + ++EV+ GVD E G + L A VS ++G+ P +
Sbjct: 242 VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN 301
Query: 275 IDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+ N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 302 LSMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+R+G++ + +
Sbjct: 359 GFDLLRSGESIRTI 372
>pdb|3BTO|A Chain A, Horse Liver Alcohol Dehydrogenase Complexed To Nadh And
(1s,3s)3-Butylthiolane 1-Oxide >gi|1941936|pdb|3BTO|B
Chain B, Horse Liver Alcohol Dehydrogenase Complexed To
Nadh And (1s,3s)3-Butylthiolane 1-Oxide
>gi|1941937|pdb|3BTO|C Chain C, Horse Liver Alcohol
Dehydrogenase Complexed To Nadh And
(1s,3s)3-Butylthiolane 1-Oxide >gi|1941938|pdb|3BTO|D
Chain D, Horse Liver Alcohol Dehydrogenase Complexed To
Nadh And (1s,3s)3-Butylthiolane 1-Oxide
>gi|443412|pdb|2OHX|A Chain A, Alcohol Dehydrogenase
(Holo Form) (E.C.1.1.1.1) Complex With Nadh And Dmso
>gi|443413|pdb|2OHX|B Chain B, Alcohol Dehydrogenase
(Holo Form) (E.C.1.1.1.1) Complex With Nadh And Dmso
>gi|2098535|pdb|1BTO|A Chain A, Horse Liver Alcohol
Dehydrogenase Complexed To Nadh And
(1s,3r)3-Butylthiolane 1-Oxide >gi|2098536|pdb|1BTO|B
Chain B, Horse Liver Alcohol Dehydrogenase Complexed To
Nadh And (1s,3r)3-Butylthiolane 1-Oxide
>gi|2098537|pdb|1BTO|C Chain C, Horse Liver Alcohol
Dehydrogenase Complexed To Nadh And
(1s,3r)3-Butylthiolane 1-Oxide >gi|2098538|pdb|1BTO|D
Chain D, Horse Liver Alcohol Dehydrogenase Complexed To
Nadh And (1s,3r)3-Butylthiolane 1-Oxide
>gi|640056|pdb|1HLD|A Chain A, Alcohol Dehydrogenase
(E.C.1.1.1.1) (Ee Isozyme) Complexed With Nicotinamide
Adenine Dinucleotide (Nad), 2,3,4,5,6-Penta-Fluorobenzyl
Alcohol, P-Bromobenzyl Alcohol And Zinc
>gi|640057|pdb|1HLD|B Chain B, Alcohol Dehydrogenase
(E.C.1.1.1.1) (Ee Isozyme) Complexed With Nicotinamide
Adenine Dinucleotide (Nad), 2,3,4,5,6-Penta-Fluorobenzyl
Alcohol, P-Bromobenzyl Alcohol And Zinc
>gi|494824|pdb|2OXI|A Chain A, Alcohol Dehydrogenase
(E.C.1.1.1.1) (Holo, Liver) Complexed With Nadh And Dmso
>gi|494825|pdb|2OXI|B Chain B, Alcohol Dehydrogenase
(E.C.1.1.1.1) (Holo, Liver) Complexed With Nadh And Dmso
>gi|1065295|pdb|1ADB|A Chain A, Alcohol Dehydrogenase
(Adh) (E.C.1.1.1.1) Complexed With
5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
(Cnad) >gi|1065296|pdb|1ADB|B Chain B, Alcohol
Dehydrogenase (Adh) (E.C.1.1.1.1) Complexed With
5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
(Cnad) >gi|231278|pdb|8ADH| Apo-Liver Alcohol
Dehydrogenase (E.C.1.1.99.8) >gi|2098481|pdb|1LDE|A
Chain A, Horse Liver Alcohol Dehydrogenase Complexed To
Nadh And N-Formyl Piperdine >gi|2098482|pdb|1LDE|B Chain
B, Horse Liver Alcohol Dehydrogenase Complexed To Nadh
And N-Formyl Piperdine >gi|2098483|pdb|1LDE|C Chain C,
Horse Liver Alcohol Dehydrogenase Complexed To Nadh And
N-Formyl Piperdine >gi|2098484|pdb|1LDE|D Chain D, Horse
Liver Alcohol Dehydrogenase Complexed To Nadh And
N-Formyl Piperdine >gi|2098334|pdb|1LDY|A Chain A, Horse
Liver Alcohol Dehydrogenase Complexed To Nadh And
Cyclohexyl Formamide (Cxf) >gi|2098335|pdb|1LDY|B Chain
B, Horse Liver Alcohol Dehydrogenase Complexed To Nadh
And Cyclohexyl Formamide (Cxf) >gi|2098336|pdb|1LDY|C
Chain C, Horse Liver Alcohol Dehydrogenase Complexed To
Nadh And Cyclohexyl Formamide (Cxf)
>gi|2098337|pdb|1LDY|D Chain D, Horse Liver Alcohol
Dehydrogenase Complexed To Nadh And Cyclohexyl Formamide
(Cxf) >gi|1065297|pdb|1ADC|A Chain A, Alcohol
Dehydrogenase (Adh) (E.C.1.1.1.1) Complexed With
5-Beta-D-Ribofuranosylpicolinamide Adenine Dinucleotide
(Cpad) >gi|1065298|pdb|1ADC|B Chain B, Alcohol
Dehydrogenase (Adh) (E.C.1.1.1.1) Complexed With
5-Beta-D-Ribofuranosylpicolinamide Adenine Dinucleotide
(Cpad) >gi|493803|pdb|1ADG| Alcohol Dehydrogenase
(E.C.1.1.1.1) Complexed With Inhibitor: Beta-Methylene
Selenazole-4-Carboxamide Adenine Dinucleotide (Beta-Sad)
>gi|231189|pdb|6ADH|A Chain A, Holo-Liver Alcohol
Dehydrogenase (E.C.1.1.1.1) Complex With Nad And Dmso
>gi|231190|pdb|6ADH|B Chain B, Holo-Liver Alcohol
Dehydrogenase (E.C.1.1.1.1) Complex With Nad And Dmso
>gi|231109|pdb|5ADH| Apo-Liver Alcohol Dehydrogenase
(E.C.1.1.1.1) Complex With Adp-Ribose
>gi|493802|pdb|1ADF| Alcohol Dehydrogenase
(E.C.1.1.1.1) Complexed With Inhibitor: Beta-Methylene
Thiazole-4-Carboxamide Adenine Dinucleotide (Beta-Tad)
>gi|229330|prf||701201A dehydrogenase E,alcohol [Equus
caballus]
Length = 374
Score = 108 bits (266), Expect = 1e-22
Identities = 107/374 (28%), Positives = 169/374 (44%), Gaps = 45/374 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++AT IC +D H+ + + + P P
Sbjct: 10 KAAVLWEEKKPFSIEEVEVAPPKAH--EVRIKMVATGICRSDDHVV-----SGTLVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I GHE AG V +G GV + GD V CGKC C+ + + C + G
Sbjct: 63 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV +V K + P E L G+
Sbjct: 123 MQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV +A G + + G G +GL I KA+GA +I + + + AK+VGA
Sbjct: 183 AVK--VAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 240
Query: 217 INPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVS 274
+NP + + ++EV+ GVD E G + L A VS ++G+ P +
Sbjct: 241 VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN 300
Query: 275 IDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+ N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 301 LSMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINE 357
Query: 331 AFELMRAGKTGKVV 344
F+L+R+G++ + +
Sbjct: 358 GFDLLRSGESIRTI 371
>gb|AAB32020.1| Class I alcohol dehydrogenase, class I ADH {EC 1.1.1.1} [Struthio
camelus=ostriches, liver, Peptide, 374 aa]
Length = 374
Score = 108 bits (266), Expect = 1e-22
Identities = 108/377 (28%), Positives = 170/377 (44%), Gaps = 45/377 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K A + +P + EV+V P EV +K+IAT IC +D H+ + + P P
Sbjct: 8 KCKAAVLWEPKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVI-----SGVLVMPFP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CG+C C + ++C I +
Sbjct: 63 IILGHEAAGVVESVGEGVTSVKPGDKVIPLFVPQCGECSVCLSTKGNLCCKNDIGPASAL 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F EY V+ V K + P E L G
Sbjct: 123 MPDGTSRFTCKGKAIHHFAGTSTFTEYTVLHETAVAKIDAAAPLEKVCLIGCGFSTGYGA 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
A+ T P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 183 ALQTAKVEP--GSTCAVFGLGGVGLSVVMGCKAAGASRIIGVDINKDKFAKAKELGATDC 240
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKV 273
+NP F + + + +M++T G GVD E G + + L + VS ++G+ P
Sbjct: 241 VNPKDFTKPIHEVLMEMT-GLGVDYSFEVIGHTETMAAALASCHFNYGVSVIVGVPPAAE 299
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
+ F+ +++F T G + G W++ +V +L+ K LDP+ITH F K
Sbjct: 300 KLSFDPMLLFSGRTWKGSVFGG--WKSKDSVPKLVADYMEKKFVLDPLITHTLP-FHKIN 356
Query: 330 EAFELMRAGKTGKVVFM 346
E F+L+R GK+ + V +
Sbjct: 357 EGFDLLRTGKSIRSVLL 373
>pdb|1AXE|A Chain A, Crystal Structure Of The Active-Site Mutant Phe93->trp Of
Horse Liver Alcohol Dehydrogenase In Complex With Nad
And Inhibitor Trifluoroethanol >gi|3114327|pdb|1AXE|B
Chain B, Crystal Structure Of The Active-Site Mutant
Phe93->trp Of Horse Liver Alcohol Dehydrogenase In
Complex With Nad And Inhibitor Trifluoroethanol
Length = 374
Score = 108 bits (266), Expect = 1e-22
Identities = 107/374 (28%), Positives = 169/374 (44%), Gaps = 45/374 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++AT IC +D H+ + + + P P
Sbjct: 10 KAAVLWEEKKPFSIEEVEVAPPKAH--EVRIKMVATGICRSDDHVV-----SGTLVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I GHE AG V +G GV + GD V CGKC C+ + + C + G
Sbjct: 63 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLWTPQCGKCRVCKHPEGNFCLKNDLSMPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV +V K + P E L G+
Sbjct: 123 MQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV +A G + + G G +GL I KA+GA +I + + + AK+VGA
Sbjct: 183 AVK--VAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 240
Query: 217 INPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVS 274
+NP + + ++EV+ GVD E G + L A VS ++G+ P +
Sbjct: 241 VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN 300
Query: 275 IDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+ N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 301 LSMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINE 357
Query: 331 AFELMRAGKTGKVV 344
F+L+R+G++ + +
Sbjct: 358 GFDLLRSGESIRTI 371
>gb|AAF23532.1|AF110434_1 (AF110434) alcohol dehydrogenase [Brassica oleracea]
Length = 379
Score = 108 bits (266), Expect = 1e-22
Identities = 106/363 (29%), Positives = 161/363 (44%), Gaps = 47/363 (12%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
+ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLXPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP++ + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPEAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED-VVKEVMDITDG 234
G +GL A+ +GA +I + + R E AKK G +NP E D V+EV+
Sbjct: 203 LGAVGLAAAEGARIAGAGRIIGVDLNPKRFEEAKKFGVTEFVNPKEHDKPVQEVIAEMTN 262
Query: 235 NGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGR 294
GVD +E +G+ +A+ Q + V V++L P K FK + + R
Sbjct: 263 GGVDRSVECTGSIQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNLLNER 315
Query: 295 HLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVV 344
L T++ V + +L L+ ITH F + +AF+ M G++ + +
Sbjct: 316 TLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRCI 374
Query: 345 FML 347
+
Sbjct: 375 ITM 377
>gb|AAF23533.1|AF110435_1 (AF110435) alcohol dehydrogenase [Capsella rubella]
Length = 379
Score = 108 bits (266), Expect = 1e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AKK G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNPSRFDQAKKFGVTEFVNPKDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK+ + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKSHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IIXM 377
>gb|AAF23546.1|AF110448_1 (AF110448) alcohol dehydrogenase [Arabis lyallii]
Length = 379
Score = 108 bits (266), Expect = 1e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ + DG
Sbjct: 83 TDLQPGDHVLPVFTGECGDCRHCHSEESNMCDLLRINTERGVMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FVGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA VI + + R + AKK G +NP + D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGASRVIGVDLNPKRFDEAKKFGVTEFVNPKDHDKPVQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK+ + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKSHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ + + + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGIVEMYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAF23548.1|AF110450_1 (AF110450) alcohol dehydrogenase [Arabis parishii]
Length = 379
Score = 108 bits (266), Expect = 1e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ + DG
Sbjct: 83 TDLQPGDHVLPVFTGECGDCRHCHSEESNMCDLLRINTERGVMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FVGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA VI + + R + AKK G +NP + D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGASRVIGVDLNPKRFDEAKKFGVTEFVNPKDHDKPVQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK+ + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKSHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ + + + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGIVEMYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>pir||DECHA1 alcohol dehydrogenase (EC 1.1.1.1) I - chicken
Length = 375
Score = 107 bits (265), Expect = 2e-22
Identities = 105/362 (29%), Positives = 160/362 (44%), Gaps = 42/362 (11%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGP 78
L EV+V P EV IK++AT IC +D H+ + P I+GHE AG + VG
Sbjct: 23 LEEVEVAPPKAHEVRIKIVATGICRSDDHVVT----GALAMPFPIILGHEAAGVIESVGE 78
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI----FGVDTDG----------- 123
V ++ GD V CG+C +C + ++C + G+ DG
Sbjct: 79 KVTSLKPGDAVIPLFVPQCGECRSCLSTKGNLCIKNDLSSSPTGLMADGTTRFTCKGKAI 138
Query: 124 -------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSV 171
F EY VV K + P E L G + T A +G +
Sbjct: 139 HHFVGTSTFTEYTVVHETAAAKIDSAAPLEKVCLIGCGFSTGYGAVLQT--AKVEAGSTC 196
Query: 172 LITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMD 230
+ G G +GL + KA+GA +I + + + AK++GA INP + + + EV+
Sbjct: 197 AVFGLGGVGLSVVMGCKAAGASRIIAVDINKDKFAKAKELGATECINPKDFKKPIHEVLT 256
Query: 231 ITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFNNLIIFKALTVY 289
G GVD E G + + L + VS ++G+ P I F+ ++IF T
Sbjct: 257 EMTGQGVDYSFEVIGRIETMTAALASCHNNYGVSVIVGVPPAAQKISFDPMLIFSGRTWK 316
Query: 290 G-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
G + G W++ V +L+ K LDP+ITH F K E F+L+R GK+ + V
Sbjct: 317 GSVFGG--WKSKDAVPKLVADYMKKKFVLDPLITHTLP-FTKINEGFDLLRTGKSIRSVL 373
Query: 346 ML 347
+L
Sbjct: 374 VL 375
>sp|P23991|ADH1_CHICK ALCOHOL DEHYDROGENASE I
Length = 376
Score = 107 bits (265), Expect = 2e-22
Identities = 105/362 (29%), Positives = 160/362 (44%), Gaps = 42/362 (11%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGP 78
L EV+V P EV IK++AT IC +D H+ + P I+GHE AG + VG
Sbjct: 24 LEEVEVAPPKAHEVRIKIVATGICRSDDHVVT----GALAMPFPIILGHEAAGVIESVGE 79
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI----FGVDTDG----------- 123
V ++ GD V CG+C +C + ++C + G+ DG
Sbjct: 80 KVTSLKPGDAVIPLFVPQCGECRSCLSTKGNLCIKNDLSSSPTGLMADGTTRFTCKGKAI 139
Query: 124 -------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSV 171
F EY VV K + P E L G + T A +G +
Sbjct: 140 HHFVGTSTFTEYTVVHETAAAKIDSAAPLEKVCLIGCGFSTGYGAVLQT--AKVEAGSTC 197
Query: 172 LITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMD 230
+ G G +GL + KA+GA +I + + + AK++GA INP + + + EV+
Sbjct: 198 AVFGLGGVGLSVVMGCKAAGASRIIAVDINKDKFAKAKELGATECINPKDFKKPIHEVLT 257
Query: 231 ITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFNNLIIFKALTVY 289
G GVD E G + + L + VS ++G+ P I F+ ++IF T
Sbjct: 258 EMTGQGVDYSFEVIGRIETMTAALASCHNNYGVSVIVGVPPAAQKISFDPMLIFSGRTWK 317
Query: 290 G-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVF 345
G + G W++ V +L+ K LDP+ITH F K E F+L+R GK+ + V
Sbjct: 318 GSVFGG--WKSKDAVPKLVADYMKKKFVLDPLITHTLP-FTKINEGFDLLRTGKSIRSVL 374
Query: 346 ML 347
+L
Sbjct: 375 VL 376
>pir||I60970 alcohol dehydrogenase (EC 1.1.1.1) I - pocket gopher hybrid
(Geomys knoxjonesi x Geomys bursarius major)
>gi|294292|gb|AAA03596.1| (L15464) alcohol dehydrogenase
[Geomys knoxjonesi x Geomys bursarius major]
Length = 375
Score = 107 bits (265), Expect = 2e-22
Identities = 107/374 (28%), Positives = 172/374 (45%), Gaps = 58/374 (15%)
Query: 10 KTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHE 68
K KP + EV+V P EV IK++AT IC +D H+ S I P P I+GHE
Sbjct: 18 KNKPF---SIEEVEVAPPKAYEVRIKIVATGICRSDDHVVN-----GSIITPLPAILGHE 69
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGVDTDG-- 123
G V +G GV ++ GD V CGKC AC+ + ++C++ + G DG
Sbjct: 70 AGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCKHGNLGRAQGTLMDGTT 129
Query: 124 ----------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VL 162
F+EY VV +V K + P E L +G T V
Sbjct: 130 RFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDATSPLEKVCL---IGCGFSTGYGSAVK 186
Query: 163 AGPISGKSVL-ITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP-- 219
G ++ S+ +G +GL I KA+GA +I + + + AK++GA +NP
Sbjct: 187 VGKVARGSICSCVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQD 246
Query: 220 FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFN 278
+++ + + + ++TDG GVD E G + L + VS ++G+ P S+ +
Sbjct: 247 YDKPIYQVLQEMTDG-GVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTMD 305
Query: 279 NLII-----FKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+++ +K G G+ V +L+ + K L+P+IT+ + F K E
Sbjct: 306 PMVLLSGRSWKGAVFGGYKGKD------DVPKLVADFMAKKFPLEPLITNVFP-FAKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+RAGK+ + V
Sbjct: 359 GFDLLRAGKSIRTV 372
>dbj|BAA19617.1| (D84242) alcohol dehydrogenase [Arabidopsis thaliana]
Length = 379
Score = 107 bits (265), Expect = 2e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TDL Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTDL--YFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG+C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLATGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D + + + ++TD
Sbjct: 203 LGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>dbj|BAA19620.1| (D84245) alcohol dehydrogenase [Arabidopsis thaliana]
>gi|1944218|dbj|BAA19623.1| (D84248) alcohol
dehydrogenase [Arabidopsis thaliana]
Length = 379
Score = 107 bits (265), Expect = 2e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TDL Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTDL--YFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG+C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D + + + ++TD
Sbjct: 203 LGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>dbj|BAA22979.1| (D63461) alcohol dehydrogenase [Arabidopsis thaliana]
Length = 379
Score = 107 bits (265), Expect = 2e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TDL Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILYTSLCHTDL--YFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG+C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D + + + ++TD
Sbjct: 203 LGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAF23536.1|AF110438_1 (AF110438) alcohol dehydrogenase [Arabis fendleri]
Length = 379
Score = 107 bits (265), Expect = 2e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P+I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTP-RFPRIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ + DG
Sbjct: 83 TDLQPGDHVLPVFTGECGDCRHCHSEESNMCDLLRINTERGVMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FVGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA VI + + R + AKK G +NP + D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGASRVIGVDLNPKRFDEAKKFGVTEFVNPKDHDKPVQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK+ + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKSHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ + + + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGIVEMYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAF23545.1|AF110447_1 (AF110447) alcohol dehydrogenase [Arabis lignifera]
Length = 379
Score = 107 bits (265), Expect = 2e-22
Identities = 104/364 (28%), Positives = 165/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ + DG
Sbjct: 83 TDLQPGDHVLPVFTGECGDCRHCHSEESNMCDLLRINTERGVMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FVGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLRATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA VI + + R + AKK G +NP + D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGASRVIGVDLNPKRFDEAKKFGVTEFVNPKDHDKPVQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK+ + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKSHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ + + + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGSYKPKTDIPGIVEMYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>emb|CAA27842.1| (X04299) gamma 2 subunit (aa 1-375) [Homo sapiens]
Length = 375
Score = 107 bits (264), Expect = 2e-22
Identities = 107/375 (28%), Positives = 170/375 (44%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC +D H+ N + P P
Sbjct: 11 KAAVLWELKKPFSIEEVEVAPPKAH--EVRIKMVAAGICRSDEHVVSGN-----LVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVKVAKVTP--GSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQ 300
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T G I G +++ +V +L+ + K +LD +IT+ F+K
Sbjct: 301 NLSINPMLLLTGRTWKGAIFGG--FKSKESVPKLVADFMAKKFSLDALITNVLP-FEKIN 357
Query: 330 EAFELMRAGKTGKVV 344
E F+L+R+GK+ + V
Sbjct: 358 EGFDLLRSGKSIRTV 372
>pir||A26468 alcohol dehydrogenase (EC 1.1.1.1) I - rat
>gi|202727|gb|AAA40681.1| (M15327) alcohol dehydrogenase
[Rattus norvegicus] >gi|225439|prf||1303272A
dehydrogenase,alcohol [Rattus norvegicus]
Length = 376
Score = 107 bits (264), Expect = 2e-22
Identities = 105/375 (28%), Positives = 170/375 (45%), Gaps = 44/375 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + +P + +++V P EV IK++AT +C +D H + + P
Sbjct: 9 KCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHAVSGSLFTPL----PA 64
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF----GV 119
++GHE AG V +G GV ++ GD V CGKC C+ + ++C TK G
Sbjct: 65 VLGHEGAGIVESIGEGVTCVKPGDKVIPLFSPQCGKCRICKHPESNLCCQTKNLTQPKGA 124
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P + L G+
Sbjct: 125 LLDGTSRFSCRGKPIHHFLSTSTFSQYTVVDDIAVAKIDAAAPLDKVCLIGCGFSTGYGS 184
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV P G + + G G +GL + K +GA +I + + + AK++GA
Sbjct: 185 AVQVAKVTP--GSTCAVFGLGGVGLSVVIGCKTAGAAKIIAVDINKDKFAKAKELGATDC 242
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKV 273
INP + + + + + ++TDG GVD E G + L + A VS ++G+ P
Sbjct: 243 INPQDYTKPIQEVLQEMTDG-GVDFSFEVIGRLDTMTSALLSCHSACGVSVIVGVPPSAQ 301
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
S+ N + + T G I G +++ V +L+ + K L+P+ITH F+K
Sbjct: 302 SLSVNPMSLLLGRTWKGAIFGG--FKSKDAVPKLVADFMAKKFPLEPLITHVLP-FEKIN 358
Query: 330 EAFELMRAGKTGKVV 344
EAF+L+RAGK+ + V
Sbjct: 359 EAFDLLRAGKSIRTV 373
>gi|9506375 Alcohol dehydrogenase 3 [Rattus norvegicus]
>gi|113392|sp|P06757|ADHA_RAT ALCOHOL DEHYDROGENASE A
CHAIN >gi|202737|gb|AAA85462.1| (M29523) alcohol
dehydrogenase [Rattus norvegicus]
Length = 376
Score = 107 bits (264), Expect = 2e-22
Identities = 105/375 (28%), Positives = 170/375 (45%), Gaps = 44/375 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + +P + +++V P EV IK++AT +C +D H + + P
Sbjct: 9 KCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHAVSGSLFTPL----PA 64
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF----GV 119
++GHE AG V +G GV ++ GD V CGKC C+ + ++C TK G
Sbjct: 65 VLGHEGAGIVESIGEGVTCVKPGDKVIPLFSPQCGKCRICKHPESNLCCQTKNLTQPKGA 124
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P + L G+
Sbjct: 125 LLDGTSRFSCRGKPIHHFISTSTFSQYTVVDDIAVAKIDAAAPLDKVCLIGCGFSTGYGS 184
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV P G + + G G +GL + K +GA +I + + + AK++GA
Sbjct: 185 AVQVAKVTP--GSTCAVFGLGGVGLSVVIGCKTAGAAKIIAVDINKDKFAKAKELGATDC 242
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKV 273
INP + + + + + ++TDG GVD E G + L + A VS ++G+ P
Sbjct: 243 INPQDYTKPIQEVLQEMTDG-GVDFSFEVIGRLDTMTSALLSCHSACGVSVIVGVPPSAQ 301
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
S+ N + + T G I G +++ V +L+ + K L+P+ITH F+K
Sbjct: 302 SLSVNPMSLLLGRTWKGAIFGG--FKSKDAVPKLVADFMAKKFPLEPLITHVLP-FEKIN 358
Query: 330 EAFELMRAGKTGKVV 344
EAF+L+RAGK+ + V
Sbjct: 359 EAFDLLRAGKSIRTV 373
>sp|P00328|ADHS_HORSE ALCOHOL DEHYDROGENASE S CHAIN >gi|625198|pir||DEHOAS alcohol
dehydrogenase (EC 1.1.1.1) S - horse
>gi|164178|gb|AAA30932.1| (M64865) alcohol
dehydrogenase-S-isoenzyme [Equus caballus]
Length = 374
Score = 107 bits (264), Expect = 2e-22
Identities = 107/373 (28%), Positives = 168/373 (44%), Gaps = 44/373 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC +D H+ + + + P P
Sbjct: 11 KAAVLWEQKKPFSIEEVEVAPPKAH--EVRIKMVAAGICRSDDHVV-----SGTLVAPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF--GVD 120
I GHE AG V +G GV + GD V CGKC C+ + ++C G
Sbjct: 64 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTM 123
Query: 121 TDGV------------------FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNA 157
DG F++Y VV +V K + P E L G+A
Sbjct: 124 QDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLVGCGFSTGYGSA 183
Query: 158 VDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI 217
V +A G + + G G +GL I KA+GA +I + + + AK+VGA +
Sbjct: 184 VK--VAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECV 241
Query: 218 NPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSI 275
NP + + ++EV+ GVD E G + L A VS ++G+ P ++
Sbjct: 242 NPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQNL 301
Query: 276 DFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEA 331
N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 302 SMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINEG 358
Query: 332 FELMRAGKTGKVV 344
F+L+R+GK+ + +
Sbjct: 359 FDLLRSGKSIRTI 371
>sp|Q64413|ADHA_GEOBU ALCOHOL DEHYDROGENASE A CHAIN >gi|2147094|pir||I60972 alcohol
dehydrogenase (EC 1.1.1.1) - pocket gopher (Geomys
bursarius) >gi|294296|gb|AAA03598.1| (L15466) alcohol
dehydrogenase [Geomys bursarius]
Length = 375
Score = 107 bits (264), Expect = 2e-22
Identities = 107/374 (28%), Positives = 172/374 (45%), Gaps = 58/374 (15%)
Query: 10 KTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHE 68
K KP + EV+V P EV IK++AT IC +D H+ S I P P I+GHE
Sbjct: 18 KNKPF---SIEEVEVAPPKAYEVRIKIVATGICRSDDHVVN-----GSIITPLPAILGHE 69
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDG-- 123
G V +G GV ++ GD V CGKC AC+ + ++C++ + G DG
Sbjct: 70 AGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCKHGDLGRAQGTLMDGTS 129
Query: 124 ----------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VL 162
F+EY VV +V K + P E L +G T V
Sbjct: 130 RFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDATSPLEKVCL---IGCGFSTGYGSAVK 186
Query: 163 AGPISGKSVL-ITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP-- 219
G ++ S+ +G +GL I KA+GA +I + + + AK++GA +NP
Sbjct: 187 VGKVARGSICSCVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQD 246
Query: 220 FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFN 278
+++ + + + ++TDG GVD E G + L + VS ++G+ P S+ +
Sbjct: 247 YDKPIYQVLQEMTDG-GVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTMD 305
Query: 279 NLII-----FKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+++ +K G G+ V +L+ + K L+P+IT+ + F K E
Sbjct: 306 PMVLLSGRSWKGAVFGGYKGKD------DVPKLVADFMAKKFPLEPLITNVFP-FAKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+RAGK+ + V
Sbjct: 359 GFDLLRAGKSIRTV 372
>pdb|1EE2|B Chain B, The Structure Of Steroid-Active Alcohol Dehydrogenase At
1.54 A Resolution >gi|300407|gb|AAB26666.1| alcohol
dehydrogenase S subunit, HLADH S chain [horses, liver,
Peptide, 373 aa]
Length = 373
Score = 107 bits (264), Expect = 2e-22
Identities = 107/373 (28%), Positives = 168/373 (44%), Gaps = 44/373 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC +D H+ + + + P P
Sbjct: 10 KAAVLWEQKKPFSIEEVEVAPPKAH--EVRIKMVAAGICRSDDHVV-----SGTLVAPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF--GVD 120
I GHE AG V +G GV + GD V CGKC C+ + ++C G
Sbjct: 63 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTM 122
Query: 121 TDGV------------------FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNA 157
DG F++Y VV +V K + P E L G+A
Sbjct: 123 QDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLVGCGFSTGYGSA 182
Query: 158 VDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI 217
V +A G + + G G +GL I KA+GA +I + + + AK+VGA +
Sbjct: 183 VK--VAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECV 240
Query: 218 NPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSI 275
NP + + ++EV+ GVD E G + L A VS ++G+ P ++
Sbjct: 241 NPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQNL 300
Query: 276 DFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEA 331
N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 301 SMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINEG 357
Query: 332 FELMRAGKTGKVV 344
F+L+R+GK+ + +
Sbjct: 358 FDLLRSGKSIRTI 370
>emb|CAA54911.1| (X77943) alcohol dehydrogenase [Arabidopsis thaliana]
>gi|1944214|dbj|BAA19619.1| (D84244) alcohol
dehydrogenase [Arabidopsis thaliana]
>gi|2570194|dbj|BAA22981.1| (D63463) alcohol
dehydrogenase [Arabidopsis thaliana]
>gi|2829917|gb|AAC00625.1| (AC002291) Alcohol
Dehydrogenase [Arabidopsis thaliana]
Length = 379
Score = 107 bits (264), Expect = 2e-22
Identities = 103/364 (28%), Positives = 165/364 (45%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG+C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D + + + ++TD
Sbjct: 203 LGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>sp|P80360|ADHX_MYXGL ALCOHOL DEHYDROGENASE CLASS III (GLUTATHIONE-DEPENDENT FORMALDEHYDE
DEHYDROGENASE) (FDH) (FALDH) >gi|1085623|pir||S51187
alcohol dehydrogenase (EC 1.1.1.1) class III - Atlantic
hagfish
Length = 376
Score = 107 bits (264), Expect = 2e-22
Identities = 104/366 (28%), Positives = 165/366 (44%), Gaps = 50/366 (13%)
Query: 19 LVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP----PQIMGHEVAGEVV 74
L E++V P EV +KV+AT++C TD + S + P P ++GHE AG V
Sbjct: 24 LEEIEVAPPKAHEVRMKVLATAVCHTD-------AYTLSGVDPEGSFPVVLGHEGAGIVE 76
Query: 75 EVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GVDTDG-------- 123
VG GV + GD V CG+C C + ++CQ ++ G+ DG
Sbjct: 77 SVGEGVTKFKPGDSVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGMMPDGTSRLTCRG 136
Query: 124 ----------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPIS------ 167
F+EYAVV ++ + PP+ L LG V T P++
Sbjct: 137 KSLYHFMGASTFSEYAVVADISLCRVAPEAPPDRVCL---LGCGVSTGYGAPLNTAKVEP 193
Query: 168 GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGA-DYVINPFEEDVVK 226
G + I G G +GL I + +GA +I + + + E A+ GA D V+ + +
Sbjct: 194 GSTCAIFGLGAVGLAAIMGCRVAGASRIIAIDRNPDKFEKARIFGATDCVVPDASDKPIS 253
Query: 227 EVM-DITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFNNLIIFK 284
+V+ ++TDG G+D E G + L++ VS +LG+ G I +
Sbjct: 254 QVLGEMTDG-GLDYTFECVGNVGIMRAALESCHKGWGVSVILGVAGGGQEISTRPFQLVT 312
Query: 285 ALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTG 341
T G W++ +V +L+ +GK+ +D ++H FD EAF+LM AGK+
Sbjct: 313 GRTWKGAAFGG-WKSVESVPKLVDDYMAGKIMVDEFVSHSLP-FDSINEAFDLMHAGKSI 370
Query: 342 KVVFML 347
+ V L
Sbjct: 371 RTVLQL 376
>sp|P79896|ADHX_SPAAU ALCOHOL DEHYDROGENASE CLASS III (GLUTATHIONE-DEPENDENT FORMALDEHYDE
DEHYDROGENASE) (FDH) (FALDH) >gi|2117436|pir||JC4967
alcohol dehydrogenase (EC 1.1.1.1) class III - gilthead
sea bream >gi|1814386|gb|AAB41888.1| (U84791) alcohol
dehydrogenase class III [Sparus aurata]
Length = 376
Score = 107 bits (264), Expect = 2e-22
Identities = 105/375 (28%), Positives = 166/375 (44%), Gaps = 44/375 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + +P + EV+V P EV IK+ AT +C TD + ++ P
Sbjct: 9 KCKAAVAWEPGKPLSIEEVEVAPPNAHEVRIKLFATGVCHTDAYTLSGSD---PEGLFPV 65
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI------- 116
I+GHE AG V VG GV + GD V CG+C C+ + ++CQ +I
Sbjct: 66 ILGHEGAGTVESVGEGVTKFKPGDTVIPLYVPQCGECKFCKNPKTNLCQKIRITQGQGLL 125
Query: 117 --------------FGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNA 157
F F+EY VV ++ K + P + L G A
Sbjct: 126 PDKTSRFTCKGKQVFHFMGTSTFSEYTVVADISLAKVNEKAPMDKVCLLGCGISTGYGAA 185
Query: 158 VDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI 217
++T P G + + G G +GL I K +GA +I + + + E AK+ GA +
Sbjct: 186 LNTAKVEP--GSTCAVFGLGAVGLAVIMGCKVAGATRIIGIDLNPAKFETAKEFGATEFV 243
Query: 218 NP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKVS 274
NP + + + ++++TDG GVD E G + + L+A G ++G+
Sbjct: 244 NPKDHSKPIQEVLVEMTDG-GVDYSFECIGNVQIMRAALEACHKGWGESVIIGVAGAGQE 302
Query: 275 IDFNNLIIFKALT--VYGITGRHLWETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYE 329
I F+ +T V+ T W++ +V +L++ S KL +D +TH F+K
Sbjct: 303 ISTRP---FQLVTGRVWKGTAFGGWKSVESVPKLVEDYMSKKLKVDEFVTHTLP-FEKIN 358
Query: 330 EAFELMRAGKTGKVV 344
E FELM AGK+ + V
Sbjct: 359 EGFELMHAGKSIRTV 373
>dbj|BAA19616.1| (D84241) alcohol dehydrogenase [Arabidopsis thaliana]
>gi|1944217|dbj|BAA19622.1| (D84247) alcohol
dehydrogenase [Arabidopsis thaliana]
>gi|6684372|gb|AAF23554.1|AF110456_1 (AF110456) alcohol
dehydrogenase [Arabidopsis thaliana]
Length = 379
Score = 107 bits (264), Expect = 2e-22
Identities = 103/364 (28%), Positives = 165/364 (45%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C+ + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCRHCKSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D + + + ++TD
Sbjct: 203 LGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>pir||A48257 alcohol dehydrogenase (EC 1.1.1.1) I - pocket gopher (Geomys
bursarius) >gi|2147098|pir||I60971 alcohol dehydrogenase
(EC 1.1.1.1) - pocket gopher hybrid (Geomys knoxjonesi x
Geomys bursarius major) >gi|294290|gb|AAA03595.1|
(L15463) alcohol dehydrogenase [Geomys bursarius]
>gi|294294|gb|AAA03597.1| (L15465) alcohol dehydrogenase
[Geomys knoxjonesi x Geomys bursarius major]
Length = 375
Score = 107 bits (264), Expect = 2e-22
Identities = 107/374 (28%), Positives = 172/374 (45%), Gaps = 58/374 (15%)
Query: 10 KTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHE 68
K KP + EV+V P EV IK++AT IC +D H+ S I P P I+GHE
Sbjct: 18 KNKPF---SIEEVEVAPPKAYEVRIKIVATGICRSDDHVVN-----GSIITPLPAILGHE 69
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDG-- 123
G V +G GV ++ GD V CGKC AC+ + ++C++ + G DG
Sbjct: 70 AGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCKHGDLGRAQGTLMDGTT 129
Query: 124 ----------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VL 162
F+EY VV +V K + P E L +G T V
Sbjct: 130 RFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDATSPLEKVCL---IGCGFSTGYGSAVK 186
Query: 163 AGPISGKSVL-ITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP-- 219
G ++ S+ +G +GL I KA+GA +I + + + AK++GA +NP
Sbjct: 187 VGKVARGSICSCVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQD 246
Query: 220 FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFN 278
+++ + + + ++TDG GVD E G + L + VS ++G+ P S+ +
Sbjct: 247 YDKPIYQVLQEMTDG-GVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTMD 305
Query: 279 NLII-----FKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+++ +K G G+ V +L+ + K L+P+IT+ + F K E
Sbjct: 306 PMVLLSGRSWKGAVFGGYKGKD------DVPKLVADFMAKKFPLEPLITNVFP-FAKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+RAGK+ + V
Sbjct: 359 GFDLLRAGKSIRTV 372
>pdb|1AXG|A Chain A, Crystal Structure Of The Val203->ala Mutant Of Liver
Alcohol Dehydrogenase Complexed With Cofactor Nad And
Inhibitor Trifluoroethanol Solved To 2.5 Angstrom
Resolution >gi|3114329|pdb|1AXG|B Chain B, Crystal
Structure Of The Val203->ala Mutant Of Liver Alcohol
Dehydrogenase Complexed With Cofactor Nad And Inhibitor
Trifluoroethanol Solved To 2.5 Angstrom Resolution
>gi|3114330|pdb|1AXG|C Chain C, Crystal Structure Of The
Val203->ala Mutant Of Liver Alcohol Dehydrogenase
Complexed With Cofactor Nad And Inhibitor
Trifluoroethanol Solved To 2.5 Angstrom Resolution
>gi|3114331|pdb|1AXG|D Chain D, Crystal Structure Of The
Val203->ala Mutant Of Liver Alcohol Dehydrogenase
Complexed With Cofactor Nad And Inhibitor
Trifluoroethanol Solved To 2.5 Angstrom Resolution
Length = 374
Score = 107 bits (264), Expect = 2e-22
Identities = 107/374 (28%), Positives = 168/374 (44%), Gaps = 45/374 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++AT IC +D H+ + + + P P
Sbjct: 10 KAAVLWEEKKPFSIEEVEVAPPKAH--EVRIKMVATGICRSDDHVV-----SGTLVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I GHE AG V +G GV + GD V CGKC C+ + + C + G
Sbjct: 63 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV +V K + P E L G+
Sbjct: 123 MQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV +A G + + G G GL I KA+GA +I + + + AK+VGA
Sbjct: 183 AVK--VAKVTQGSTCAVFGLGGAGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 240
Query: 217 INPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVS 274
+NP + + ++EV+ GVD E G + L A VS ++G+ P +
Sbjct: 241 VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN 300
Query: 275 IDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+ N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 301 LSMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINE 357
Query: 331 AFELMRAGKTGKVV 344
F+L+R+G++ + +
Sbjct: 358 GFDLLRSGESIRTI 371
>pdb|1A71|A Chain A, Ternary Complex Of An Active Site Double Mutant Of Horse
Liver Alcohol Dehydrogenase, Phe93>trp, Val203>ala With
Nad And Trifluoroethanol >gi|3318997|pdb|1A71|B Chain B,
Ternary Complex Of An Active Site Double Mutant Of Horse
Liver Alcohol Dehydrogenase, Phe93>trp, Val203>ala With
Nad And Trifluoroethanol >gi|3318998|pdb|1A72| An
Active-Site Double Mutant (Phe93->trp, Val203->ala) Of
Horse Liver Alcohol Dehydrogenase In Complex With The
Isosteric Nad Analog Cpad
Length = 374
Score = 107 bits (264), Expect = 2e-22
Identities = 107/374 (28%), Positives = 168/374 (44%), Gaps = 45/374 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++AT IC +D H+ + + + P P
Sbjct: 10 KAAVLWEEKKPFSIEEVEVAPPKAH--EVRIKMVATGICRSDDHVV-----SGTLVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I GHE AG V +G GV + GD V CGKC C+ + + C + G
Sbjct: 63 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLWTPQCGKCRVCKHPEGNFCLKNDLSMPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV +V K + P E L G+
Sbjct: 123 MQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV +A G + + G G GL I KA+GA +I + + + AK+VGA
Sbjct: 183 AVK--VAKVTQGSTCAVFGLGGAGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 240
Query: 217 INPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVS 274
+NP + + ++EV+ GVD E G + L A VS ++G+ P +
Sbjct: 241 VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQN 300
Query: 275 IDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+ N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 301 LSMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINE 357
Query: 331 AFELMRAGKTGKVV 344
F+L+R+G++ + +
Sbjct: 358 GFDLLRSGESIRTI 371
>gb|AAC98958.1| (AF044728) alcohol dehydrogenase [Geomys bursarius major]
Length = 375
Score = 107 bits (264), Expect = 2e-22
Identities = 107/374 (28%), Positives = 171/374 (45%), Gaps = 58/374 (15%)
Query: 10 KTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHE 68
K KP + EV+V P EV IK++AT IC +D H+ S I P P I+GHE
Sbjct: 18 KNKPF---SIEEVEVAPPKAYEVRIKIVATGICRSDDHVVN-----GSIITPLPAILGHE 69
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDG-- 123
G V +G GV ++ GD V CGKC AC+ + ++C++ + G DG
Sbjct: 70 AGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCKHGDLGRAQGTLMDGTT 129
Query: 124 ----------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VL 162
F+EY VV +V K + P E L +G T V
Sbjct: 130 RFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDATSPLEKVCL---IGCGFSTGYGSAVK 186
Query: 163 AGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP-- 219
G ++ G +G +GL I KA+GA +I + + + AK++GA +NP
Sbjct: 187 VGKVARGSICACVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQD 246
Query: 220 FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFN 278
+++ + + + ++TDG GVD E G + L + VS ++G+ P S+ +
Sbjct: 247 YDKPIYQVLQEMTDG-GVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTID 305
Query: 279 NLII-----FKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+++ +K G G+ V +L+ + K L+P+IT+ + F K E
Sbjct: 306 PMVLLSGRSWKGAVFGGYKGKD------DVPKLVADFMAKKFPLEPLITNVFP-FAKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+RAGK+ + V
Sbjct: 359 GFDLLRAGKSIRTV 372
>sp|P12711|ADHX_RAT ALCOHOL DEHYDROGENASE CLASS III (ALCOHOL DEHYDROGENASE 2)
(GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE) (FDH)
(FALDH) (ALCOHOL DEHYDROGENASE-B2) >gi|65894|pir||DERTA
alcohol dehydrogenase (EC 1.1.1.1) 2 - rat
Length = 373
Score = 107 bits (264), Expect = 2e-22
Identities = 105/359 (29%), Positives = 161/359 (44%), Gaps = 40/359 (11%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
E++V P EV IK+IAT++C TD + A P I+GHE AG V VG GV
Sbjct: 23 EIEVAPPQAHEVRIKIIATAVCHTDAYTLSG---ADPEGCFPVILGHEGAGIVESVGEGV 79
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GVDTDG-------------- 123
++ GD V CG+C C + ++CQ ++ G+ DG
Sbjct: 80 TKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKPILHF 139
Query: 124 ----VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAVDTVLAGPISGKSVLIT 174
F+EY VV +V K S P + L G AV+T P G + +
Sbjct: 140 MGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEP--GSTCAVF 197
Query: 175 GAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEEDVVKEVMDIT 232
G G +GL I K +GA +I + + + AK+ GA INP F + + + ++++T
Sbjct: 198 GLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGATECINPQDFSKSIQEVLIEMT 257
Query: 233 DGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFNNLIIFKALTVYGI 291
DG GVD E G K + L+A VS ++G+ I + T G
Sbjct: 258 DG-GVDFSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKG- 315
Query: 292 TGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
T W++ +V +L+ S K+ +D +T FD+ +AF+LM +G + + V L
Sbjct: 316 TAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNL-SFDQINKAFDLMHSGNSIRTVLKL 373
>gb|AAD09950.1| (L30113) alcohol dehydrogenase; ADH [Papio hamadryas]
Length = 375
Score = 107 bits (264), Expect = 2e-22
Identities = 106/377 (28%), Positives = 171/377 (45%), Gaps = 47/377 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC +D H+ + + + P P
Sbjct: 11 KAAVLWEVKKPFSIEEVEVAPPKAH--EVRIKMVAVGICRSDDHVV-----SGTLVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 AILGHEAAGIVEGVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCFKNDLSNPRGT 123
Query: 120 DTDGV------------------FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G
Sbjct: 124 MQDGTRRFTCGGKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGP 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVKVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTIMASLLCCHEACGTSVIVGVPPDSQ 300
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T G I G +++ +V +L+ + K +LD +IT+ F+K
Sbjct: 301 NLSINPVLLLTGRTWKGAIFGG--FKSKESVPKLVSDFMAKKFSLDALITNVLP-FEKIN 357
Query: 330 EAFELMRAGKTGKVVFM 346
E F+L+R+GK+ + + M
Sbjct: 358 EGFDLLRSGKSIRTILM 374
>pir||T33939 probable alcohol dehydrogenase (EC 1.1.1.1) [similarity] -
Caenorhabditis elegans >gi|4262561|gb|AAD14690.1|
(AF125951) similar to zinc-binding dehydrogenases
(Pfam:PF00107, Score=356.6, E=2.7e-103, N=1)
[Caenorhabditis elegans]
Length = 408
Score = 107 bits (264), Expect = 2e-22
Identities = 95/310 (30%), Positives = 144/310 (45%), Gaps = 35/310 (11%)
Query: 14 AYGA--ELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAG 71
+YG E+ ++ +P+P E+L+K+ + IC +D+H + + S K P I GHE AG
Sbjct: 17 SYGGPLEIKQLPIPQPNEDELLVKMEYSGICHSDVHTWLGDFHYVS--KCPMIGGHEGAG 74
Query: 72 EVVEVGPGVEGIEVGDYVSVETHIV-----------------CGKCYACRRGQYHVCQNT 114
V+ VG V+ ++GD V ++ C C C+ G +C +
Sbjct: 75 SVISVGSKVKNWQIGDKVGIKVSQTLNSSSLNFNIFQLVQGNCLNCEYCQTGHEPLCPHV 134
Query: 115 KIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLA----GPISGKS 170
GV G F EYA + + K PKS+ A L V A SG+
Sbjct: 135 WNIGVQKYGTFQEYATIRDVDAIKIPKSM--NMAAAAPVLCGGVTAYKALKESEVKSGQI 192
Query: 171 VLITGA-GPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPF-EEDVVKEV 228
V +TGA G LG I A+A G V + PS + K +GA++ ++ F ED+V +
Sbjct: 193 VAVTGAGGGLGSFAIQYARAMGMRVVAIDHPS--KEAHCKSLGAEWFVDAFGTEDIVAHI 250
Query: 229 MDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGL-YPGKVSIDFNNLIIFKALT 287
+ITDG G + F+ A +E+ L+ V G V +GL K+ +D L IF A+
Sbjct: 251 REITDG-GAHGVVNFAAAKVPMEKALEYVRKRGTVVFVGLAKDSKILVDTIPL-IFNAVK 308
Query: 288 VYG-ITGRHL 296
+ G I G L
Sbjct: 309 IKGSIVGSRL 318
>gb|AAF23529.1|AF110431_1 (AF110431) alcohol dehydrogenase [Arabis blepharophylla]
Length = 379
Score = 107 bits (264), Expect = 2e-22
Identities = 103/364 (28%), Positives = 162/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
+ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLAPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSIDGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY V+ + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FVGTSTFSEYTVIHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AKK G +NP + D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSKRFDEAKKFGVTEFVNPKDHDKPVQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L ++ ITH F + +AF+ M G+ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEQYMNKELEIEKFITHTVP-FSEINKAFDYMLKGEGNRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IIRM 377
>pdb|1EE2|A Chain A, The Structure Of Steroid-Active Alcohol Dehydrogenase At
1.54 A Resolution
Length = 373
Score = 107 bits (264), Expect = 2e-22
Identities = 107/373 (28%), Positives = 168/373 (44%), Gaps = 44/373 (11%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC +D H+ + + + P P
Sbjct: 10 KAAVLWEQKKPFSIEEVEVAPPKAH--EVRIKMVAAGICRSDDHVV-----SGTLVAPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF--GVD 120
I GHE AG V +G GV + GD V CGKC C+ + ++C G
Sbjct: 63 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTM 122
Query: 121 TDGV------------------FAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNA 157
DG F++Y VV +V K + P E L G+A
Sbjct: 123 QDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLVGCGFSTGYGSA 182
Query: 158 VDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI 217
V +A G + + G G +GL I KA+GA +I + + + AK+VGA +
Sbjct: 183 VK--VAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECV 240
Query: 218 NPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSI 275
NP + + ++EV+ GVD E G + L A VS ++G+ P ++
Sbjct: 241 NPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQNL 300
Query: 276 DFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEEA 331
N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 301 SMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINEG 357
Query: 332 FELMRAGKTGKVV 344
F+L+R+GK+ + +
Sbjct: 358 FDLLRSGKSIRTI 370
>sp|P06525|ADH1_ARATH ALCOHOL DEHYDROGENASE >gi|65899|pir||DEMUAM alcohol dehydrogenase
(EC 1.1.1.1) - Arabidopsis thaliana
>gi|166584|gb|AAA32728.1| (M12196) alcohol dehydrogenase
[Arabidopsis thaliana] >gi|1944210|dbj|BAA19615.1|
(D84240) alcohol dehydrogenase [Arabidopsis thaliana]
>gi|1944213|dbj|BAA19618.1| (D84243) alcohol
dehydrogenase [Arabidopsis thaliana]
>gi|1944219|dbj|BAA19624.1| (D84249) alcohol
dehydrogenase [Arabidopsis thaliana]
>gi|2570188|dbj|BAA22983.1| (D63460) alcohol
dehydrogenase [Arabidopsis thaliana]
>gi|2570192|dbj|BAA22980.1| (D63462) alcohol
dehydrogenase [Arabidopsis thaliana]
>gi|2570196|dbj|BAA22982.1| (D63464) alcohol
dehydrogenase [Arabidopsis thaliana]
Length = 379
Score = 106 bits (263), Expect = 3e-22
Identities = 103/364 (28%), Positives = 165/364 (45%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C+ + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCRHCQSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D + + + ++TD
Sbjct: 203 LGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gi|4501933 class I alcohol dehydrogenase 3 gamma subunit; alcohol
dehydrogenase (class I), gamma polypeptide; aldehyde
reductase; alcohol dehydrogenase 3 (class I), gamma
polypeptide [Homo sapiens]
>gi|113398|sp|P00326|ADHG_HUMAN ALCOHOL DEHYDROGENASE
GAMMA CHAIN >gi|625196|pir||DEHUAG alcohol dehydrogenase
(EC 1.1.1.1) 3 - human >gi|178148|gb|AAC41757.1|
(M12272) alcohol dehydrogenase 1 [Homo sapiens]
Length = 375
Score = 106 bits (263), Expect = 3e-22
Identities = 107/375 (28%), Positives = 170/375 (44%), Gaps = 47/375 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++A IC +D H+ N + P P
Sbjct: 11 KAAVLWELKKPFSIEEVEVAPPKAH--EVRIKMVAAGICRSDEHVVSGN-----LVTPLP 63
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI---FGV 119
I+GHE AG V VG GV ++ GD V CGKC C+ + + C + G
Sbjct: 64 VILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGT 123
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV V K + P E L G+
Sbjct: 124 LQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGS 183
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV P G + + G G +GL + KA+GA +I + + + AK++GA
Sbjct: 184 AVKVAKVTP--GSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATEC 241
Query: 217 INP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKV 273
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 242 INPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ 300
Query: 274 SIDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYE 329
++ N +++ T G I G +++ +V +L+ + K +LD +IT+ F+K
Sbjct: 301 NLSINPMLLLTGRTWKGAIFGG--FKSKESVPKLVADFMAKKFSLDALITN-ILPFEKIN 357
Query: 330 EAFELMRAGKTGKVV 344
E F+L+R+GK+ + V
Sbjct: 358 EGFDLLRSGKSIRTV 372
>gb|AAF23551.1|AF110453_1 (AF110453) alcohol dehydrogenase [Arabidopsis lyrata subsp.
petraea]
Length = 379
Score = 106 bits (263), Expect = 3e-22
Identities = 104/364 (28%), Positives = 164/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSQRFDQAKEFGVTEFVNPRDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVIEKYMNKELELEKFITHTLP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ L
Sbjct: 374 IITL 377
>pir||I60974 alcohol dehydrogenase (EC 1.1.1.1) - pocket gopher (Geomys
knoxjonesi) >gi|294300|gb|AAA03600.1| (L15461) alcohol
dehydrogenase [Geomys knoxjonesi]
Length = 375
Score = 106 bits (262), Expect = 4e-22
Identities = 107/374 (28%), Positives = 171/374 (45%), Gaps = 58/374 (15%)
Query: 10 KTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHE 68
K KP + EV+V P EV IK++AT IC +D H+ S I P P I+GHE
Sbjct: 18 KNKPF---SIEEVEVAPPKAYEVRIKIVATGICRSDDHVVN-----GSIITPLPAILGHE 69
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDG-- 123
G V +G GV ++ GD V CGKC AC+ + ++C + + G DG
Sbjct: 70 AGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCTHGDLGRAQGTLMDGTS 129
Query: 124 ----------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VL 162
F+EY VV +V K + P E L +G T V
Sbjct: 130 RFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDAASPLEKVCL---IGCGFSTGYGSAVK 186
Query: 163 AGPISGKSVL-ITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP-- 219
G ++ S+ +G +GL I KA+GA +I + + + AK++GA +NP
Sbjct: 187 VGKVARGSICSCVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQD 246
Query: 220 FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFN 278
+++ + + + ++TDG GVD E G + L + VS ++G+ P S+ +
Sbjct: 247 YDKPIYQVLQEMTDG-GVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTMD 305
Query: 279 NLII-----FKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+++ +K G G+ V +L+ + K L+P+IT+ + F K E
Sbjct: 306 PMVLLSGRSWKGAVFGGYKGKD------DVPKLVADFMAKKFPLEPLITNVFP-FAKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+RAGK+ + V
Sbjct: 359 GFDLLRAGKSIRTV 372
>dbj|BAA22975.1| (D63456) alcohol dehydrogenase [Arabis gemmifera]
Length = 379
Score = 106 bits (262), Expect = 4e-22
Identities = 103/364 (28%), Positives = 164/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPKKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGGGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSSQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSQRFDQAKEFGVTEFVNPRDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAF23537.1|AF110439_1 (AF110439) alcohol dehydrogenase [Arabis glabra]
Length = 379
Score = 106 bits (262), Expect = 4e-22
Identities = 103/364 (28%), Positives = 164/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVGKPKRGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D V + + ++TD
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSKRFDQAKEFGVTEFVNPKDHDKPVQQVLAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK+ + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKSHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMMKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>pir||F81097 probable alcohol dehydrogenase (EC 1.1.1.1) class III NMA1518
[similarity] - Neisseria meningitidis (group B strain
MD58, group A strain Z2491) >gi|7226545|gb|AAF41679.1|
(AE002479) alcohol dehydrogenase, class III [Neisseria
meningitidis MC58] >gi|7380160|emb|CAB84746.1|
(AL162756) alcohol dehydrogenase class-III [Neisseria
meningitidis Z2491]
Length = 378
Score = 106 bits (262), Expect = 4e-22
Identities = 102/372 (27%), Positives = 170/372 (45%), Gaps = 38/372 (10%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + P ++VE+DV P GEVLI+ T +C TD ++ P
Sbjct: 11 KSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSD---PEGVFPV 67
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFGVD 120
++GHE AG VV VG GV ++ GD+V CG+C C G+ ++C ++T+ G+
Sbjct: 68 VLGHEGAGVVVAVGEGVSSVKPGDHVIPLYTAECGECEFCCSGKTNLCVSVRDTQGKGLM 127
Query: 121 TDG------------------VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTV 161
DG F+EY+VV ++ K NP++ + L + + V
Sbjct: 128 PDGTTRFSYQGQPIYHYMGCSTFSEYSVVAEVSLAKINPEANHEQVCLLGCGVTTGIGAV 187
Query: 162 --LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP 219
A G SV + G G +GL + A+ + A +I + + + ELAK+ GA +NP
Sbjct: 188 HNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPSKFELAKQFGATDCLNP 247
Query: 220 FEED-VVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPG--KVSI 275
+ D +K+V+ + G+D E G + Q L++ G+ ++G+ ++S
Sbjct: 248 NDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEIST 307
Query: 276 DFNNLI---IFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAF 332
L+ ++K G+ GR S G + L+P +TH D+ +AF
Sbjct: 308 RPFQLVTGRVWKGSAFGGVKGRSELPKMVEDS---MKGDIELEPFVTHTMT-LDQINKAF 363
Query: 333 ELMRAGKTGKVV 344
+LM GK+ + V
Sbjct: 364 DLMHEGKSIRAV 375
>sp|Q64415|ADHA_GEOKN ALCOHOL DEHYDROGENASE A CHAIN >gi|2147095|pir||I60973 alcohol
dehydrogenase (EC 1.1.1.1) I - pocket gopher (Geomys
knoxjonesi) >gi|294298|gb|AAA03599.1| (L15462) alcohol
dehydrogenase [Geomys knoxjonesi]
Length = 375
Score = 106 bits (261), Expect = 5e-22
Identities = 107/374 (28%), Positives = 171/374 (45%), Gaps = 58/374 (15%)
Query: 10 KTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHE 68
K KP + EV+V P EV IK++AT IC +D H+ S I P P I+GHE
Sbjct: 18 KNKPF---SIEEVEVVPPKAYEVRIKIVATGICRSDDHVVN-----GSIITPLPAILGHE 69
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDG-- 123
G V +G GV ++ GD V CGKC AC+ + ++C + + G DG
Sbjct: 70 AGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCTHGDLGRAQGTLMDGTS 129
Query: 124 ----------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VL 162
F+EY VV +V K + P E L +G T V
Sbjct: 130 RFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDAASPLEKVCL---IGCGFSTGYGSAVK 186
Query: 163 AGPISGKSVL-ITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP-- 219
G ++ S+ +G +GL I KA+GA +I + + + AK++GA +NP
Sbjct: 187 VGKVARGSICSCVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQD 246
Query: 220 FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFN 278
+++ + + + ++TDG GVD E G + L + VS ++G+ P S+ +
Sbjct: 247 YDKPIYQVLQEMTDG-GVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTMD 305
Query: 279 NLII-----FKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+++ +K G G+ V +L+ + K L+P+IT+ + F K E
Sbjct: 306 PMVLLSGRSWKGAVFGGYKGKD------DVPKLVADFMAKKFPLEPLITNVFP-FAKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+RAGK+ + V
Sbjct: 359 GFDLLRAGKSIRTV 372
>gi|4501941 class IV alcohol dehydrogenase 7 mu or sigma subunit; alcohol
dehydrogenase-7; alcohol dehydrogenase 7 (class IV), mu
or sigma polypeptide; aldehyde reductase; retinol
dehydrogenase; gastric alcohol dehydrogenase [Homo
sapiens] >gi|728806|sp|P40394|ADH7_HUMAN ALCOHOL
DEHYDROGENASE CLASS IV MU/SIGMA CHAIN (RETINOL
DEHYDROGENASE) (GASTRIC ALCOHOL DEHYDROGENASE)
>gi|2144313|pir||DEHUAS alcohol dehydrogenase (EC
1.1.1.1) 7 [validated] - human >gi|499098|gb|AAA19002.1|
(U07821) alcohol dehydrogenase [Homo sapiens]
>gi|516618|gb|AAA59211.1| (L33179) alcohol dehydrogenase
[Homo sapiens] >gi|541676|emb|CAA53961.1| (X76342)
alcohol dehydrogenase [Homo sapiens]
>gi|642482|gb|AAC51351.1| (U16293) class IV alcohol
dehydrogenase [Homo sapiens] >gi|790524|gb|AAA82165.1|
(U09623) alcohol dehydrogenase [Homo sapiens]
Length = 374
Score = 106 bits (261), Expect = 5e-22
Identities = 107/371 (28%), Positives = 164/371 (43%), Gaps = 40/371 (10%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K + + K + E +EV PK EV IK++AT IC TD H+ + + K P
Sbjct: 11 KAAVLWEQKQPFSIEEIEVAPPKTK--EVRIKILATGICRTDDHVIKGTMVS----KFPV 64
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF--GVDT 121
I+GHE G V +G GV ++ GD V C +C ACR ++C + I GV
Sbjct: 65 IVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLA 124
Query: 122 DG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAV 158
DG F EY VV +V K + PPE L G AV
Sbjct: 125 DGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAV 184
Query: 159 DTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVIN 218
T P G + ++ G G +GL I K++GA +I + + + E A VGA I+
Sbjct: 185 KTGKVKP--GSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECIS 242
Query: 219 PFEE-DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVSID 276
P + + EV+ GN V E G + + L + G ++G+ P +
Sbjct: 243 PKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLT 302
Query: 277 FNNLIIFKALTVYGITGRHLWETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYEEAFE 333
++ +++F T G L ++ V +L+ + K +LD +ITH F K E FE
Sbjct: 303 YDPMLLFTGRTWKGCVFGGL-KSRDDVPKLVTEFLAKKFDLDQLITHVLP-FKKISEGFE 360
Query: 334 LMRAGKTGKVV 344
L+ +G++ + V
Sbjct: 361 LLNSGQSIRTV 371
>emb|CAA53960.1| (X76342) alternative ORF [Homo sapiens]
Length = 386
Score = 106 bits (261), Expect = 5e-22
Identities = 107/371 (28%), Positives = 164/371 (43%), Gaps = 40/371 (10%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K + + K + E +EV PK EV IK++AT IC TD H+ + + K P
Sbjct: 23 KAAVLWEQKQPFSIEEIEVAPPKTK--EVRIKILATGICRTDDHVIKGTMVS----KFPV 76
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF--GVDT 121
I+GHE G V +G GV ++ GD V C +C ACR ++C + I GV
Sbjct: 77 IVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLA 136
Query: 122 DG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAV 158
DG F EY VV +V K + PPE L G AV
Sbjct: 137 DGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAV 196
Query: 159 DTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVIN 218
T P G + ++ G G +GL I K++GA +I + + + E A VGA I+
Sbjct: 197 KTGKVKP--GSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECIS 254
Query: 219 PFEE-DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVSID 276
P + + EV+ GN V E G + + L + G ++G+ P +
Sbjct: 255 PKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLT 314
Query: 277 FNNLIIFKALTVYGITGRHLWETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYEEAFE 333
++ +++F T G L ++ V +L+ + K +LD +ITH F K E FE
Sbjct: 315 YDPMLLFTGRTWKGCVFGGL-KSRDDVPKLVTEFLAKKFDLDQLITHVLP-FKKISEGFE 372
Query: 334 LMRAGKTGKVV 344
L+ +G++ + V
Sbjct: 373 LLNSGQSIRTV 383
>sp|P72324|ADHI_RHOSH ALCOHOL DEHYDROGENASE CLASS III (GLUTATHIONE-DEPENDENT FORMALDEHYDE
DEHYDROGENASE) (FDH) (FALDH) (GSH-FDH)
>gi|986949|gb|AAB09774.1| (L47326) alcohol dehydrogenase
[Rhodobacter sphaeroides]
Length = 376
Score = 106 bits (261), Expect = 5e-22
Identities = 106/383 (27%), Positives = 172/383 (44%), Gaps = 68/383 (17%)
Query: 6 VAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP---- 61
VA+ KP E++EV++ P GEV++++ AT IC TD E+ S P
Sbjct: 7 VAVEAGKPL---EIMEVNLEGPKAGEVMVEIKATGICHTD-------EFTLSGADPEGMF 56
Query: 62 PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFG 118
P I+GHE AG VVEVGPGV ++ GD+V C +C +C + ++C + T+ G
Sbjct: 57 PAILGHEGAGVVVEVGPGVTSVKPGDHVIPLYTPECRQCPSCLSQKTNLCTAIRGTQGQG 116
Query: 119 VDTDG-------------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVD 159
+ DG F+ Y V+P V K P + +G V
Sbjct: 117 LMPDGTSRFSMLDGTPILHYMGCSTFSNYTVLPEIAVAKVRPDAPFDKICY---IGCGVT 173
Query: 160 TVLAGPIS------GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGA 213
T + I+ G ++ G G +GL I K +GA +I + ++ ++E ++ G
Sbjct: 174 TGIGAVINTAKVEIGAKAVVFGLGGIGLNVIQGLKLAGADMIIGVDLNNAKKEWGERFGM 233
Query: 214 DYVINPFE--EDVVKEVMDITDG-----NGVDVFLEFSGAPKALEQGLQAVTPA-GRVSL 265
+ +NP E DVV ++++T G D + +G K + Q L+A G+ +
Sbjct: 234 THFVNPSEIDGDVVAHLVNMTKTPFDQIGGADYTFDCTGNVKVMRQALEACHRGWGQSIV 293
Query: 266 LGLYPGKVSIDFN--NLI---IFKALTVYGITGR---HLWETWYTVSRLLQSGKLNLDPI 317
+G+ P I L+ ++K G GR WY GK+ +DP+
Sbjct: 294 IGVAPAGAEIQTRPFQLVTGRVWKGSAFGGARGRTDVPKIVDWY------MEGKIQIDPM 347
Query: 318 ITHKYKGFDKYEEAFELMRAGKT 340
ITH ++ + F+LM AG++
Sbjct: 348 ITH-ILSLEEINKGFDLMHAGES 369
>pdb|1D1S|A Chain A, Wild-Type Human Sigma (Class Iv) Alcohol Dehydrogenase
>gi|6137443|pdb|1D1S|B Chain B, Wild-Type Human Sigma
(Class Iv) Alcohol Dehydrogenase >gi|6137444|pdb|1D1S|C
Chain C, Wild-Type Human Sigma (Class Iv) Alcohol
Dehydrogenase >gi|6137445|pdb|1D1S|D Chain D, Wild-Type
Human Sigma (Class Iv) Alcohol Dehydrogenase
>gi|1942122|pdb|1AGN|A Chain A, X-Ray Structure Of Human
Sigma Alcohol Dehydrogenase >gi|1942123|pdb|1AGN|B Chain
B, X-Ray Structure Of Human Sigma Alcohol Dehydrogenase
>gi|1942124|pdb|1AGN|C Chain C, X-Ray Structure Of Human
Sigma Alcohol Dehydrogenase >gi|1942125|pdb|1AGN|D Chain
D, X-Ray Structure Of Human Sigma Alcohol Dehydrogenase
Length = 373
Score = 106 bits (261), Expect = 5e-22
Identities = 107/371 (28%), Positives = 164/371 (43%), Gaps = 40/371 (10%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K + + K + E +EV PK EV IK++AT IC TD H+ + + K P
Sbjct: 10 KAAVLWEQKQPFSIEEIEVAPPKTK--EVRIKILATGICRTDDHVIKGTMVS----KFPV 63
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF--GVDT 121
I+GHE G V +G GV ++ GD V C +C ACR ++C + I GV
Sbjct: 64 IVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLA 123
Query: 122 DG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAV 158
DG F EY VV +V K + PPE L G AV
Sbjct: 124 DGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAV 183
Query: 159 DTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVIN 218
T P G + ++ G G +GL I K++GA +I + + + E A VGA I+
Sbjct: 184 KTGKVKP--GSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECIS 241
Query: 219 PFEE-DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVSID 276
P + + EV+ GN V E G + + L + G ++G+ P +
Sbjct: 242 PKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLT 301
Query: 277 FNNLIIFKALTVYGITGRHLWETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYEEAFE 333
++ +++F T G L ++ V +L+ + K +LD +ITH F K E FE
Sbjct: 302 YDPMLLFTGRTWKGCVFGGL-KSRDDVPKLVTEFLAKKFDLDQLITHVLP-FKKISEGFE 359
Query: 334 LMRAGKTGKVV 344
L+ +G++ + V
Sbjct: 360 LLNSGQSIRTV 370
>dbj|BAA22973.1| (D63454) alcohol dehydrogenase [Arabis gemmifera]
>gi|2570182|dbj|BAA22976.1| (D63457) alcohol
dehydrogenase [Arabis gemmifera]
Length = 379
Score = 106 bits (261), Expect = 5e-22
Identities = 103/364 (28%), Positives = 164/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSQRFDQAKEFGVTEFVNPRDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAC98957.1| (AF044724) alcohol dehydrogenase [Geomys knoxjonesi]
Length = 375
Score = 106 bits (261), Expect = 5e-22
Identities = 107/374 (28%), Positives = 170/374 (44%), Gaps = 58/374 (15%)
Query: 10 KTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-PQIMGHE 68
K KP + EV+V P EV IK++AT IC +D H+ S I P P I+GHE
Sbjct: 18 KNKPF---SIEEVEVVPPKAYEVRIKIVATGICRSDDHVVN-----GSIITPLPAILGHE 69
Query: 69 VAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQN---TKIFGVDTDG-- 123
G V +G GV ++ GD V CGKC AC+ + ++C + + G DG
Sbjct: 70 AGGIVESIGEGVTTVKPGDKVIPLFVPQCGKCRACKHPESNLCTHGDLGRAQGTLMDGTS 129
Query: 124 ----------------VFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDT-----VL 162
F+EY VV +V K + P E L +G T V
Sbjct: 130 RFTCKGKPIHHFLGVTTFSEYTVVSEISVTKIDAASPLEKVCL---IGCGFSTGYGSAVK 186
Query: 163 AGPIS-GKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP-- 219
G ++ G +G +GL I KA+GA +I + + + AK++GA +NP
Sbjct: 187 VGKVARGSICACVWSGRVGLSAIIGCKAAGAARIIAVDINKDKFAKAKELGATECVNPQD 246
Query: 220 FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVSIDFN 278
+++ + + + ++TDG GVD E G + L + VS ++G+ P S+ +
Sbjct: 247 YDKPIYQVLQEMTDG-GVDFSFEVIGRLDTMVSALMCCQESHGVSVIVGVPPNAQSLTMD 305
Query: 279 NLII-----FKALTVYGITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+++ +K G G+ V +L+ + K L+P+IT+ + F K E
Sbjct: 306 PMVLLSGRSWKGAVFGGYKGKD------DVPKLVADFMAKKFPLEPLITNVFP-FAKINE 358
Query: 331 AFELMRAGKTGKVV 344
F+L+RAGK+ + V
Sbjct: 359 GFDLLRAGKSIRTV 372
>pdb|1D1T|A Chain A, Mutant Of Human Sigma Alcohol Dehydrogenase With Leucine
At Position 141 >gi|6137447|pdb|1D1T|B Chain B, Mutant
Of Human Sigma Alcohol Dehydrogenase With Leucine At
Position 141 >gi|6137448|pdb|1D1T|C Chain C, Mutant Of
Human Sigma Alcohol Dehydrogenase With Leucine At
Position 141 >gi|6137449|pdb|1D1T|D Chain D, Mutant Of
Human Sigma Alcohol Dehydrogenase With Leucine At
Position 141
Length = 373
Score = 106 bits (261), Expect = 5e-22
Identities = 107/371 (28%), Positives = 164/371 (43%), Gaps = 40/371 (10%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K + + K + E +EV PK EV IK++AT IC TD H+ + + K P
Sbjct: 10 KAAVLWEQKQPFSIEEIEVAPPKTK--EVRIKILATGICRTDDHVIKGTMVS----KFPV 63
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF--GVDT 121
I+GHE G V +G GV ++ GD V C +C ACR ++C + I GV
Sbjct: 64 IVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLA 123
Query: 122 DG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGNAV 158
DG F EY VV +V K + PPE L G AV
Sbjct: 124 DGTTRFTCKGKPVHHFLNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAV 183
Query: 159 DTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVIN 218
T P G + ++ G G +GL I K++GA +I + + + E A VGA I+
Sbjct: 184 KTGKVKP--GSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECIS 241
Query: 219 PFEE-DVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAV-TPAGRVSLLGLYPGKVSID 276
P + + EV+ GN V E G + + L + G ++G+ P +
Sbjct: 242 PKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLT 301
Query: 277 FNNLIIFKALTVYGITGRHLWETWYTVSRLLQ---SGKLNLDPIITHKYKGFDKYEEAFE 333
++ +++F T G L ++ V +L+ + K +LD +ITH F K E FE
Sbjct: 302 YDPMLLFTGRTWKGCVFGGL-KSRDDVPKLVTEFLAKKFDLDQLITHVLP-FKKISEGFE 359
Query: 334 LMRAGKTGKVV 344
L+ +G++ + V
Sbjct: 360 LLNSGQSIRTV 370
>gb|AAF23540.1|AF110442_1 (AF110442) alcohol dehydrogenase [Arabidopsis halleri]
Length = 379
Score = 106 bits (261), Expect = 5e-22
Identities = 103/364 (28%), Positives = 164/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSQRFDQAKEFGVTEFVNPRDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAF23541.1|AF110443_1 (AF110443) alcohol dehydrogenase [Arabis hirsuta]
Length = 379
Score = 106 bits (261), Expect = 5e-22
Identities = 104/364 (28%), Positives = 164/364 (44%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
+ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLAPGDHVLPVFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSIDGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FVGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AKK G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSKRFDEAKKFGVTEFVNPKDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q L+ V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQALECVHDGWGVAVLVGVPSKDD-------AFKTHPMNLLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ + G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYILKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>pdb|1QLH|A Chain A, Horse Liver Alcohol Dehydrogenase Complexed To Nad Double
Mutant Of Gly 293 Ala And Pro 295 Thr
>gi|6730483|pdb|1QLJ|A Chain A, Horse Liver Alcohol
Dehydrogenase Apo Enzyme Double Mutant Of Gly 293 Ala
And Pro 295 Thr
Length = 374
Score = 106 bits (261), Expect = 5e-22
Identities = 106/374 (28%), Positives = 168/374 (44%), Gaps = 45/374 (12%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKP-P 62
K + + K + E VEV PK EV IK++AT IC +D H+ + + + P P
Sbjct: 10 KAAVLWEEKKPFSIEEVEVAPPKAH--EVRIKMVATGICRSDDHVV-----SGTLVTPLP 62
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIF---GV 119
I GHE AG V +G GV + GD V CGKC C+ + + C + G
Sbjct: 63 VIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGT 122
Query: 120 DTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEPLGN 156
DG F++Y VV +V K + P E L G+
Sbjct: 123 MQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGS 182
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
AV +A G + + G G +GL I KA+GA +I + + + AK+VGA
Sbjct: 183 AVK--VAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 240
Query: 217 INPFE-EDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVS-LLGLYPGKVS 274
+NP + + ++EV+ GVD E G + L A VS ++ + P +
Sbjct: 241 VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVAVTPDSQN 300
Query: 275 IDFNNLIIFKALTVYG-ITGRHLWETWYTVSRLL---QSGKLNLDPIITHKYKGFDKYEE 330
+ N +++ T G I G +++ +V +L+ + K LDP+ITH F+K E
Sbjct: 301 LSMNPMLLLSGRTWKGAIFGG--FKSKDSVPKLVADFMAKKFALDPLITHVLP-FEKINE 357
Query: 331 AFELMRAGKTGKVV 344
F+L+R+G++ + +
Sbjct: 358 GFDLLRSGESIRTI 371
>gb|AAK41061.1| Alcohol dehydrogenase (Zn containing) (adh-2) [Sulfolobus
solfataricus]
Length = 333
Score = 105 bits (260), Expect = 7e-22
Identities = 105/350 (30%), Positives = 173/350 (49%), Gaps = 30/350 (8%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M A++ G + EV P PG EV+I+V ++C DL + R+K P I
Sbjct: 1 MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQG---FYPRMKYPVI 57
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
+GHEV G + ++G +G + GD V + G C+ C+ G+ C + + + DG
Sbjct: 58 LGHEVVGTIEQIGENAKGFKEGDKVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGF 117
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGA-GPLGL 181
FAE A V ++ K ++P E A L + V L A G++VL+TGA G +G+
Sbjct: 118 FAEKAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKLQKGETVLVTGASGGVGI 177
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI--NPFEEDVVKEVMDITDGNGVDV 239
I VAKA GA VI S+ + +K AD+VI + F E+ K++ D V+V
Sbjct: 178 HAIQVAKALGA-KVIGVTTSEEKAAFIRKF-ADHVIVGSKFSEE-AKKIGD------VNV 228
Query: 240 FLEFSGAPKALEQGLQAVTPAGRVSLLG-LYPGKVSIDFNNLIIFKALTVYG---ITGRH 295
++ G P +++ L+++ GR+ +G + P ++ +I K + + G T R
Sbjct: 229 VIDTVGTP-TIDESLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRD 287
Query: 296 LWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMR-AGKTGKVV 344
ET +L GK+N P+I G D+ ++ +E+++ K GKV+
Sbjct: 288 AEET----LKLTGEGKIN--PVIAATV-GLDEIDKGYEILKDKHKIGKVL 330
>emb|CAB57539.1| (Y18930) alcohol dehydrogenase (Zn containing) [Sulfolobus
solfataricus]
Length = 333
Score = 105 bits (260), Expect = 7e-22
Identities = 105/350 (30%), Positives = 173/350 (49%), Gaps = 30/350 (8%)
Query: 5 MVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQI 64
M A++ G + EV P PG EV+I+V ++C DL + R+K P I
Sbjct: 1 MKAVVVPGKQKGYRIEEVSDPIPGKDEVVIRVNRAALCYRDLLQLQG---FYPRMKYPVI 57
Query: 65 MGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGV 124
+GHEV G + ++G +G + GD V + G C+ C+ G+ C + + + DG
Sbjct: 58 LGHEVVGTIEQIGENAKGFKEGDKVISLLYAPDGTCHYCQMGEEAYCHSRVGYSEELDGF 117
Query: 125 FAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITGA-GPLGL 181
FAE A V ++ K ++P E A L + V L A G++VL+TGA G +G+
Sbjct: 118 FAEKAKVKVTSIVKVGTNVPDEGAVLVPCVTGMVYRSLRRAKLQKGETVLVTGASGGVGI 177
Query: 182 LGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVI--NPFEEDVVKEVMDITDGNGVDV 239
I VAKA GA VI S+ + +K AD+VI + F E+ K++ D V+V
Sbjct: 178 HAIQVAKALGA-KVIGVTTSEEKAAFIRKF-ADHVIVGSKFSEE-AKKIGD------VNV 228
Query: 240 FLEFSGAPKALEQGLQAVTPAGRVSLLG-LYPGKVSIDFNNLIIFKALTVYG---ITGRH 295
++ G P +++ L+++ GR+ +G + P ++ +I K + + G T R
Sbjct: 229 VIDTVGTP-TIDESLKSLWMGGRLVQIGNVDPTQIYQLRLGYVILKDIAIIGHASATKRD 287
Query: 296 LWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMR-AGKTGKVV 344
ET +L GK+N P+I G D+ ++ +E+++ K GKV+
Sbjct: 288 AEET----LKLTGEGKIN--PVIAATV-GLDEIDKGYEILKDKHKIGKVL 330
>gb|AAD46162.1|AF130307_1 (AF130307) glutathione-dependent formaldehyde dehydrogenase
[Acinetobacter baumannii]
Length = 369
Score = 105 bits (260), Expect = 7e-22
Identities = 102/378 (26%), Positives = 169/378 (43%), Gaps = 50/378 (13%)
Query: 4 KMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
K A + P E+VE+DV P GEVLIK+ T +C TD ++ P
Sbjct: 2 KSRAAVAFAPGKPLEIVEIDVAPPKAGEVLIKITHTGVCHTDAFTLSGDD---PEGVFPA 58
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVC---QNTKIFGVD 120
I+GHE AG V+EVG GV ++ GD+V C +C C+ G+ ++C + T+ GV
Sbjct: 59 ILGHEGAGVVIEVGEGVTSVQPGDHVIPLYTAECKECLFCKSGKTNLCVAVRATQGKGVM 118
Query: 121 TDG------------------VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTV 161
DG F+EY VV ++ K NP++ + L + + V
Sbjct: 119 PDGTTRFSYKGEPIYHYMGCSTFSEYTVVAEVSLAKINPEANHEQVCLLGCGVTTGIGAV 178
Query: 162 --LAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP 219
A G SV + G G +GL + A+ + A +IV + + + ELAK+ GA +NP
Sbjct: 179 HNTAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDTNPDKFELAKQFGATDFLNP 238
Query: 220 --FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYPGKVSID 276
+++ + + ++++T G GVD E G + L+ G+ ++G+ I
Sbjct: 239 KDYDQPIQQVIVEMT-GWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEIS 297
Query: 277 FNNLIIFKALTVYGITGRHLWETWY-------TVSRLLQ---SGKLNLDPIITHKYKGFD 326
+ +TGR T + + ++++ G + L+P +TH
Sbjct: 298 TRPFQL--------VTGRKWLGTAFGGVKGRSQLPKMVEDAMKGDIQLEPFVTHTMP-LQ 348
Query: 327 KYEEAFELMRAGKTGKVV 344
AF+LM GK+ + V
Sbjct: 349 DINTAFDLMHEGKSIRTV 366
>gi|4501931 class I alcohol dehydrogenase 2 beta subunit; aldehyde reductase;
alcohol dehydrogenase 2 (class I), beta polypeptide
[Homo sapiens] >gi|178100|gb|AAA51592.1| (M21692)
alcohol dehydrogenase beta-1 subunit (EC 1.1.1.1) [Homo
sapiens]
Length = 375
Score = 105 bits (259), Expect = 9e-22
Identities = 107/378 (28%), Positives = 164/378 (43%), Gaps = 47/378 (12%)
Query: 1 MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIK 60
M K + + K + E VEV PK EV IK++A IC TD H+ + +
Sbjct: 8 MKCKAAVLWEVKKPFSIEDVEVAPPKAY--EVRIKMVAVGICRTDDHVV-----SGKLVT 60
Query: 61 P-PQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKI--- 116
P P I+GHE AG V VG GV ++ GD V CGKC C+ + + C +
Sbjct: 61 PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNP 120
Query: 117 FGVDTDG------------------VFAEYAVVPAQNVWKNPKSIPPEYATL-----QEP 153
G DG F++Y VV V K + E L
Sbjct: 121 RGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASKLEKVCLIGCGFSTG 180
Query: 154 LGNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGA 213
G+AV+ P G + + G G +GL + KA+GA +I + + + AK +GA
Sbjct: 181 YGSAVNVAKVTP--GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKVLGA 238
Query: 214 DYVINP--FEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPA-GRVSLLGLYP 270
INP +++ + + + ++TDG GVD E G + L A G ++G+ P
Sbjct: 239 TECINPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPP 297
Query: 271 GKVSIDFNNLIIFKALT----VYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFD 326
++ N +++ T VYG G E + + K +LD +ITH F+
Sbjct: 298 ASQNLSINPMLLLTGRTWKGAVYG--GFKSKEGIPKLVADFMAKKFSLDALITHVLP-FE 354
Query: 327 KYEEAFELMRAGKTGKVV 344
K E F+L+ +GK+ + V
Sbjct: 355 KINEGFDLLHSGKSIRTV 372
>dbj|BAA22974.1| (D63455) alcohol dehydrogenase [Arabis gemmifera]
Length = 379
Score = 105 bits (259), Expect = 9e-22
Identities = 102/357 (28%), Positives = 166/357 (45%), Gaps = 35/357 (9%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSQRFDQAKEFGVTEFVNPRDHDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGK-VSIDFNNLIIFKALTVYG-I 291
G GVD +E +G+ +A+ Q + V V++L P K + + + T+ G
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDDAFKTHPMNFLNERTLKGTF 321
Query: 292 TGRHLWET-WYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 347
+G + +T V + +L L+ ITH F + +AF+ M G++ + + +
Sbjct: 322 SGNYKPKTDMPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRCIITM 377
>gb|AAC62469.1| (AF079058) alcohol dehydrogenase Adh-1 [Glycine max]
Length = 374
Score = 105 bits (259), Expect = 9e-22
Identities = 105/368 (28%), Positives = 163/368 (43%), Gaps = 58/368 (15%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHE--VAGEVVEVGP 78
EV+V P GEV +K++ TS+C TD +Y W+ A+ P+I GHE V G V VG
Sbjct: 21 EVEVAPPQAGEVRLKILYTSLCHTD--VYFWD--AKQTPLFPRIFGHEASVGGIVESVGE 76
Query: 79 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTD---------------- 122
GV ++ GD+ CG C C+ + ++C+ + ++TD
Sbjct: 77 GVTHLKPGDHALPVFTGECGDCAHCKSEESNMCE---LLRINTDRGVMIHDGQSRFSKNG 133
Query: 123 ---------GVFAEYAVVPAQNVWK-NPKSIPPEYATLQEPL--GNAVDTVLAGPISGKS 170
F+EY VV A V K NP + + L + G +A P G S
Sbjct: 134 QPIHHFLGTSTFSEYTVVHAGCVAKINPAAPLDKVCVLSCGICTGFGATVNVAKPKPGSS 193
Query: 171 VLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEV 228
V I G G + + A+ SGA +I + R E AKK G + +NP + D V + +
Sbjct: 194 VAIFGLGAVAVAAAEGARVSGASRIIGVDLVSARFEEAKKFGVNEFVNPKDHDKPVQQVI 253
Query: 229 MDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTV 288
++T+G GVD +E +G+ +A+ + V +++L P K FK +
Sbjct: 254 AEMTNG-GVDRAVECTGSIQAMVSAFECVHDGWGLAVLVGVPSKDD-------AFKTAPI 305
Query: 289 YGITGRHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAG 338
+ R L T+Y +V SG+L +D ITH F + +AF+LM G
Sbjct: 306 NFLNERTLKGTFYGNYKPRTDLPSVVEKYMSGELEVDKFITHTVP-FSEINKAFDLMLKG 364
Query: 339 KTGKVVFM 346
++ M
Sbjct: 365 SIRCIIRM 372
>sp|P47734|FADH_METMR GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE (FDH) (FALDH)
>gi|496118|gb|AAA65728.1| (L33464) alcohol dehydrogenase
3 [Methylobacter marinus]
Length = 424
Score = 104 bits (258), Expect = 1e-21
Identities = 105/397 (26%), Positives = 165/397 (41%), Gaps = 63/397 (15%)
Query: 8 IMKTKPAYGAELVEVD-VPKP---GPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQ 63
+MK +G V VD VP P P + ++K+ AT+ICG+DLH+Y+ ++
Sbjct: 34 VMKALCWHGKYDVRVDTVPDPIIVDPTDAIVKITATAICGSDLHLYDGY---MPTMESGD 90
Query: 64 IMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNT--------K 115
I+GHE GEVVEVG V ++ GD V V I CG C+ C + Y C + K
Sbjct: 91 ILGHEPMGEVVEVGSEVTSLKTGDRVVVPFTISCGHCFFCEKTLYSCCDTSNPNADMARK 150
Query: 116 IFGVDTDGVF-------------AEYAVVPAQNVW--KNPKSIPPEYATLQE---PLG-N 156
G G+F AEY VP +V K +P + P G
Sbjct: 151 AMGHSPAGIFGYSHMLGGFAGGQAEYLRVPYADVGPIKITSDLPDDKVLFLSDIFPTGYM 210
Query: 157 AVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYV 216
A + P G +V + G GP+ I GA VI + R +A++ G +
Sbjct: 211 AAENAQIEP--GDTVAVWGCGPVAQFVIQSCWMLGAGRVIAIDRVPERLTMAQEHGKAEI 268
Query: 217 INPFEEDVVKEVMDITDGNGVDVFLEFSGA-------------------------PKALE 251
I+ EEDV +M +T+G G D ++ G P L
Sbjct: 269 IDFEEEDVYDRLMAMTNGRGPDCCIDAVGCEAHGAGSFDAVLDKAKAALYLGTDRPHVLR 328
Query: 252 QGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGK 311
+ + G VS+ G+Y G + + K LT+ + H+ + ++ +
Sbjct: 329 EAIMCCRKGGTVSIPGVYVGLLDQLPMGAAMNKGLTL-KMGQTHVQRYLEPLLEKIEEDQ 387
Query: 312 LNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK 348
++ +ITH G D+ +A++ R + G + +LK
Sbjct: 388 IDPSFVITHSL-GLDEGPQAYKTFRDKEDGCIKVVLK 423
>gi|6319621 alcohol dehydrogenase isoenzyme V; Adh5p [Saccharomyces cerevisiae]
>gi|584729|sp|P38113|ADH5_YEAST ALCOHOL DEHYDROGENASE V
>gi|626095|pir||S46016 alcohol dehydrogenase (EC
1.1.1.1) 5 - yeast (Saccharomyces cerevisiae)
>gi|536448|emb|CAA85103.1| (Z36014) ORF YBR145w
[Saccharomyces cerevisiae]
Length = 351
Score = 104 bits (258), Expect = 1e-21
Identities = 91/275 (33%), Positives = 135/275 (49%), Gaps = 17/275 (6%)
Query: 3 EKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPP 62
EK AI+ + E +V VP+P P E+L+ V + +C +DLH + +W ++K P
Sbjct: 8 EKQKAIVFYETDGKLEYKDVTVPEPKPNEILVHVKYSGVCHSDLHAWH-GDWP-FQLKFP 65
Query: 63 QIMGHEVAGEVVEVGPGVEGIEVGDYVSVE-THIVCGKCYACRRGQYHVCQNTKIFGVDT 121
I GHE AG VV++G V+G +VGD+ ++ + C C C G C G
Sbjct: 66 LIGGHEGAGVVVKLGSNVKGWKVGDFAGIKWLNGTCMSCEYCEVGNESQCPYLDGTGFTH 125
Query: 122 DGVFAEYAVVPAQNVWKNPKSIPPEYATLQ-EPLGNAVDTVL-----AGPISGKSVLITG 175
DG F EYA A IPP + P+ A TV A I G+ V I+G
Sbjct: 126 DGTFQEYATADAVQA----AHIPPNVNLAEVAPILCAGITVYKALKRANVIPGQWVTISG 181
Query: 176 A-GPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEE-DVVKEVMDITD 233
A G LG L I A A G Y VI + + +R+L +++G + I+ EE D+V ++ T+
Sbjct: 182 ACGGLGSLAIQYALAMG-YRVIGIDGGNAKRKLFEQLGGEIFIDFTEEKDIVGAIIKATN 240
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGL 268
G V + S + A+E + P G V L+G+
Sbjct: 241 GGSHGV-INVSVSEAAIEASTRYCRPNGTVVLVGM 274
>dbj|BAA19621.1| (D84246) alcohol dehydrogenase [Arabidopsis thaliana]
Length = 379
Score = 104 bits (258), Expect = 1e-21
Identities = 102/364 (28%), Positives = 164/364 (45%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+C TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLCHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG+C C + ++C N + G+ DG
Sbjct: 83 TDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINPERGGMIHDGESRFSINGKPIYH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NP + + + L + L A P G+SV I G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEED--VVKEVMDITD 233
G +GL A+ +GA +I + + R + AK+ G +NP + D + + + ++TD
Sbjct: 203 LGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTD 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
R L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 RTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
>gb|AAC79416.1| (AF037558) alcohol dehydrogenase 2 [Leavenworthia stylosa]
Length = 379
Score = 104 bits (258), Expect = 1e-21
Identities = 102/364 (28%), Positives = 166/364 (45%), Gaps = 49/364 (13%)
Query: 21 EVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGV 80
EV+V P EV IK++ TS+ TD +Y W Q+ + P +I GHE G V VG GV
Sbjct: 26 EVEVAPPQKHEVRIKILFTSLWHTD--VYFWEAKGQTPLFP-RIFGHEAGGIVESVGEGV 82
Query: 81 EGIEVGDYVSVETHIVCGKCYACRRGQYHVCQ----NTKIFGVDTDG------------- 123
++ GD+V CG C C + ++C NT+ G+ DG
Sbjct: 83 TDLKPGDHVLPIFTGECGDCPHCHSEESNMCDLLRINTERRGMIHDGESRFSINGKPIHH 142
Query: 124 -----VFAEYAVVPAQNVWK-NPKSIPPEYATLQEPLGNAVDTVL--AGPISGKSVLITG 175
F+EY VV + V K NPK+ + + L + +L A P G+SV + G
Sbjct: 143 FLGTSTFSEYTVVHSGQVAKINPKAPLDKVWIVSWGLSTGLGAILNVAKPKKGQSVAVFG 202
Query: 176 AGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINP--FEEDVVKEVMDITD 233
G +GL A+ +GA +I + + R E AKK G +NP +++ V + + ++T+
Sbjct: 203 LGAVGLAAAEGARIAGASRIIGVDLNSKRFEEAKKFGVTEFVNPKDYDKPVQQVIAEMTN 262
Query: 234 GNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITG 293
G GVD +E +G+ +A+ Q + V V++L P K FK + +
Sbjct: 263 G-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDD-------AFKTHPMNFLNE 314
Query: 294 RHLWETWY----------TVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKV 343
+ L T++ V + +L L+ ITH F + +AF+ M G++ +
Sbjct: 315 KTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVP-FSEINKAFDYMLKGESIRC 373
Query: 344 VFML 347
+ +
Sbjct: 374 IITM 377
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.139 0.415
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 140793235
Number of Sequences: 2977
Number of extensions: 6301431
Number of successful extensions: 19022
Number of sequences better than 1.0e-10: 619
Number of HSP's better than 0.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 560
Number of HSP's that attempted gapping in prelim test: 17253
Number of HSP's gapped (non-prelim): 650
length of query: 348
length of database: 189,106,746
effective HSP length: 54
effective length of query: 294
effective length of database: 156,788,448
effective search space: 46095803712
effective search space used: 46095803712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)