BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2400 (purC)
DE:phosphoribosylaminoimidazolesuccinocarboxamide synthase (purC)
(234 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||A75212 phosphoribosylaminoimidazolesuccinocarboxamide synth... 478 e-134
sp|O57978|PUR7_PYRHO PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 437 e-122
sp|Q58987|PUR7_METJA PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 241 5e-63
pir||G75545 phosphoribosylaminoimidazole-succinocarboxamide synt... 225 3e-58
sp|P12046|PUR7_BACSU PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 224 7e-58
sp|O67881|PUR7_AQUAE PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 218 6e-56
dbj|BAB04345.1| (AP001509) phosphoribosylaminoimidazole succinoc... 212 4e-54
pir||A81397 phosphoribosylaminoimidazolesuccinocarboxamide synth... 210 9e-54
sp|P73471|PUR7_SYNY3 PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 210 2e-53
sp|O26272|PUR7_METTH PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 209 3e-53
sp|Q07296|PUR7_STRPN PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 207 1e-52
pir||T51698 phosphoribosylaminoimidazolesuccinocarboxamide synth... 206 2e-52
gb|AAK40937.1| Phosphoribosylaminoimidazole-succinocarboxamide s... 199 2e-50
emb|CAB57674.1| (Y18930) phosphoribosylaminoimidazole-succinocar... 199 2e-50
pir||F83520 phosphoribosylaminoimidazole-succinocarboxamide synt... 198 5e-50
sp|P21155|PUR7_ECOLI PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 192 4e-48
sp|Q9X0X0|PUR7_THEMA PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 171 5e-42
sp|O05946|PUR7_RICPR PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 125 5e-28
gb|AAF53199.1| (AE003636) CG17024 gene product [Drosophila melan... 120 2e-26
gb|AAF06355.1|AF102579_1 (AF102579) 5'-phosphoribosylaminoimidaz... 115 4e-25
gb|AAG22346.1| (AE003490) ade5 gene product [Drosophila melanoga... 110 1e-23
gi|5453539 multifunctional polypeptide similar to SAICAR synthet... 109 3e-23
sp|Q10457|PUR6_CAEEL PROBABLE MULTIFUNCTIONAL PROTEIN ADE2 [INCL... 107 1e-22
sp|P51583|PUR6_RAT MULTIFUNCTIONAL PROTEIN ADE2 [INCLUDES: PHOSP... 107 1e-22
sp|P38024|PUR6_CHICK MULTIFUNCTIONAL PROTEIN ADE2 [INCLUDES: PHO... 106 3e-22
emb|CAC11454.1| (AL445063) phosphoribosylamidoimidazole-succinoc... 93 2e-18
sp|O68830|PUR7_LACLA PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 93 3e-18
sp|P50124|PUR7_PICJA PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXA... 92 5e-18
gi|6319326 phosphoribosyl amino imidazolesuccinocarbozamide synt... 91 9e-18
pdb|1A48| Saicar Synthase 91 9e-18
sp|P27616|PUR7_YEAST PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXA... 91 1e-17
sp|P43851|PUR7_HAEIN PUTATIVE PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCI... 87 2e-16
pir||B81161 phosphoribosylaminoimidazole-succinocarboxamide synt... 87 2e-16
pir||G81943 probable phosphoribosylaminoimidazolesuccinocarboxam... 86 4e-16
gb|AAF97181.1|AF268611_4 (AF268611) SAICAR synthase [uncultured ... 86 4e-16
dbj|BAA89448.1| (AB003161) 5'-phosphoribosyl-4-N-succinocarboxam... 83 3e-15
gb|AAC15763.1| (AF060796) putative multifunctional protein ADE2 ... 81 1e-14
sp|O08361|PUR7_MYCLE PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 79 5e-14
pir||T40437 phosphoribosylamidoimidazole-succinocarboxamide synt... 78 7e-14
sp|P27602|PUR7_CANMA PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXA... 78 1e-13
sp|P43060|PUR7_CANAL PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXA... 76 5e-13
pir||S55293 phosphoribosylaminoimidazolesuccinocarboxamide synth... 75 6e-13
pir||S55291 phosphoribosylaminoimidazolesuccinocarboxamide synth... 75 8e-13
pir||S55292 phosphoribosylaminoimidazolesuccinocarboxamide synth... 75 1e-12
sp|Q59566|PUR7_MYCTU PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXA... 74 1e-12
gb|AAB41456.1| (U34957) phosphoribosylaminoimidazolesuccinocarbo... 73 3e-12
emb|CAB56351.1| (AL118514) phosphoribosylaminoimidazole-succinoc... 70 3e-11
>pir||A75212 phosphoribosylaminoimidazolesuccinocarboxamide synthase (purc)
PAB2400 - Pyrococcus abyssi (strain Orsay)
>gi|5457653|emb|CAB49144.1| (AJ248283)
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(purC) [Pyrococcus abyssi]
Length = 234
Score = 478 bits (1217), Expect = e-134
Identities = 234/234 (100%), Positives = 234/234 (100%)
Query: 1 MEVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
MEVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG
Sbjct: 1 MEVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD
Sbjct: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
Query: 121 ELHDPMINYYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
ELHDPMINYYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG
Sbjct: 121 ELHDPMINYYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRITGEDPGN 234
EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRITGEDPGN
Sbjct: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRITGEDPGN 234
>sp|O57978|PUR7_PYRHO PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|7437944|pir||H71247 probable
phosphoribosylaminoimidazole-succinocarboxamide synthase
- Pyrococcus horikoshii >gi|3256628|dbj|BAA29311.1|
(AP000001) 238aa long hypothetical
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Pyrococcus horikoshii]
Length = 238
Score = 437 bits (1112), Expect = e-122
Identities = 208/232 (89%), Positives = 225/232 (96%)
Query: 1 MEVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
MEVYEGKAKKMIP+DDDK IMEFKDDATAFDG KKA+FKGKGWLNAQ+S FFKLLEEHG
Sbjct: 5 MEVYEGKAKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHG 64
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
IKTHFIGVAG N+LIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYK+D
Sbjct: 65 IKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKND 124
Query: 121 ELHDPMINYYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
ELHDPMINYYHAK+LGI+L+EIKK+EEIALKVNEILKDYLAK+GIILVDFKLEFGK+KNG
Sbjct: 125 ELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEFGKDKNG 184
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRITGEDP 232
+I+LADEISPDTCRFWDA+TK+SLDKDVFRFDKGDLIEAY+E+Y RITGE P
Sbjct: 185 DIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERITGEKP 236
>sp|Q58987|PUR7_METJA PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|2129197|pir||G64498
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - Methanococcus jannaschii
>gi|1592203|gb|AAB99610.1| (U67599)
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(purC) [Methanococcus jannaschii]
Length = 242
Score = 241 bits (609), Expect = 5e-63
Identities = 120/226 (53%), Positives = 163/226 (72%), Gaps = 1/226 (0%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
+Y GKAK + +DDDK ++EF+DD TA +G K +GKG+LNA IS+K F+ LEE+G+K
Sbjct: 14 LYSGKAKSIYEIDDDKVLIEFRDDITAGNGAKHDVKQGKGYLNALISSKLFEALEENGVK 73
Query: 63 THFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDEL 122
TH+I +I +K+++ P+EV+VRN+ AGSL +R P EG ELP PIV+ YK+DE
Sbjct: 74 THYIKYIEPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYPFEEGKELPFPIVQFDYKNDEY 133
Query: 123 HDPMINYYHAKILGI-TLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNGE 181
DPM+N A LG+ T EE+ K++EIALKVNE+LK ++GIILVDFK+E GK++ G
Sbjct: 134 GDPMLNEDIAVALGLATREELNKIKEIALKVNEVLKKLFDEKGIILVDFKIEIGKDREGN 193
Query: 182 IILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRI 227
+++ADEISPDT R WD ET+ LDKDVFR D GD+I Y + R+
Sbjct: 194 LLVADEISPDTMRLWDKETRDVLDKDVFRKDLGDVIAKYRIVAERL 239
>pir||G75545 phosphoribosylaminoimidazole-succinocarboxamide synthase -
Deinococcus radiodurans (strain R1)
>gi|6457896|gb|AAF09811.1|AE001884_6 (AE001884)
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Deinococcus radiodurans]
Length = 294
Score = 225 bits (568), Expect = 3e-58
Identities = 115/229 (50%), Positives = 157/229 (68%), Gaps = 2/229 (0%)
Query: 4 YEGKAKKMIPMDDD-KFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
YEGKAK++ ++ ++++E+KDDATAF+ K+ ++ GKG N I+A + LE GI
Sbjct: 65 YEGKAKRVYATENPHEYVVEYKDDATAFNAQKRGEWAGKGATNNAITAHLYPQLEAAGIP 124
Query: 63 THFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDEL 122
THF+ D + V+ + + P+EV+VRNV AGS KRL + EG LP P+VE YKSD L
Sbjct: 125 THFLEKLSDREQRVKAVTIVPVEVIVRNVAAGSFSKRLGVEEGTPLPRPVVEYCYKSDAL 184
Query: 123 HDPMINYYHAKILGITLEE-IKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNGE 181
DP+IN A LG E+ +K++ E+AL++ + L Y KRG+ L+DFKLEFGK +GE
Sbjct: 185 GDPLINTDTAVALGWASEDDLKRIRELALQIRDFLVPYFEKRGVRLIDFKLEFGKLPSGE 244
Query: 182 IILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRITGE 230
I+LADEISPDTCRFWDAET + +DKD FR D G EAY E+ +R+T E
Sbjct: 245 IVLADEISPDTCRFWDAETNEKMDKDRFRRDLGGEAEAYAEMLKRVTRE 293
>sp|P12046|PUR7_BACSU PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) (VEGETATIVE PROTEIN 286A) (VEG286A)
>gi|68623|pir||CEBSSC
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - Bacillus subtilis
>gi|143367|gb|AAA22677.1| (J02732) phosphoribosyl
aminoidazole succinocarboxamide synthetase (PUR-C; gtg
start codon) [Bacillus subtilis]
>gi|2632959|emb|CAB12465.1| (Z99107)
phosphoribosylaminoimidazole succinocarboxamide
synthetase [Bacillus subtilis]
Length = 241
Score = 224 bits (565), Expect = 7e-58
Identities = 114/229 (49%), Positives = 156/229 (67%), Gaps = 2/229 (0%)
Query: 3 VYEGKAKKMIPMDDDKFI-MEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+YEGKAKK+ DD+ + + +KD ATAF+G KKA+ GKG LN +IS+ FK L GI
Sbjct: 9 LYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAEISGKGRLNNEISSLIFKHLHAKGI 68
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
HFI + + +++K+ + PLEVVVRNVVAGS+ KRL +PEG EL +PI+E YYK D
Sbjct: 69 NNHFIERISETEQLIKKVTIVPLEVVVRNVVAGSMSKRLGIPEGTELEQPIIEFYYKDDA 128
Query: 122 LHDPMINYYHAKIL-GITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
L DP+I H +L T E+++ ++ I VNE L+ + L+DFKLEFG + G
Sbjct: 129 LGDPLITEDHIWLLKAATPEQVETIKSITTIVNEELQSIFDDCHVRLIDFKLEFGLDAEG 188
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRITG 229
+++LADEISPDTCR WD ET + LDKD+FR + G L +AYEE++ R+ G
Sbjct: 189 QVLLADEISPDTCRLWDKETNEKLDKDLFRRNLGSLTDAYEEIFNRLGG 237
>sp|O67881|PUR7_AQUAE PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|7437943|pir||E70481
phosphoribosylaminoimidazole-succinocarboxamide synthase
- Aquifex aeolicus >gi|2984328|gb|AAC07849.1| (AE000774)
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Aquifex aeolicus]
Length = 216
Score = 218 bits (549), Expect = 6e-56
Identities = 109/201 (54%), Positives = 147/201 (72%), Gaps = 2/201 (0%)
Query: 2 EVYEGKAKKMIPMDD-DKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
++YEGKAK + D+ DK I+EFKD ATAFDGVKK + KGKG LN +IS+ F++LE+HG
Sbjct: 6 KLYEGKAKIVYETDEKDKLILEFKDVATAFDGVKKEEIKGKGSLNNEISSLIFEILEDHG 65
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
IKTH+I D +++V + + +P+EVVVRN AGS KR + EG +L +P+VE + KSD
Sbjct: 66 IKTHYIKKLSDREMLVWRAERFPVEVVVRNYAAGSFVKRYGVKEGTKLEQPLVEFFMKSD 125
Query: 121 ELHDPMINYYHAKILGIT-LEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKN 179
ELHDPM+ H K+L + E + +ME+IALKVNEILK ++GI+LVDFKLEFG+ +
Sbjct: 126 ELHDPMVCINHIKVLKLAPAELVPEMEKIALKVNEILKKIFEEKGILLVDFKLEFGRLPS 185
Query: 180 GEIILADEISPDTCRFWDAET 200
GE+ + DEISPD+ R WD T
Sbjct: 186 GELAIVDEISPDSMRLWDKST 206
>dbj|BAB04345.1| (AP001509) phosphoribosylaminoimidazole succinocarboxamide
synthetase [Bacillus halodurans]
Length = 237
Score = 212 bits (533), Expect = 4e-54
Identities = 106/227 (46%), Positives = 156/227 (68%), Gaps = 2/227 (0%)
Query: 3 VYEGKAKKMIPMDDDKFI-MEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+YEGKAKK+ D++ + +E+K+ ATAF+G KKA +GK LN +IS+ F L+E G+
Sbjct: 7 LYEGKAKKIYRTDEEGLLWVEYKNSATAFNGEKKASIEGKARLNNEISSLIFSYLKEQGV 66
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
+HF+ + + ++ ++ + PLEVVVRNV+AGSL KR+ + EG L +P+VE YYK D+
Sbjct: 67 DSHFVKRLSETEQLIHQVTIIPLEVVVRNVIAGSLAKRIGIEEGTPLEKPLVEFYYKDDD 126
Query: 122 LHDPMINYYHAKIL-GITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
L DP++ H IL T E++ ++ A++VN+ L + A G+ LVDFKLEFG +G
Sbjct: 127 LGDPLVTEDHIAILQAATKEQVDILKVKAIEVNDALTTFFAGIGVKLVDFKLEFGVTADG 186
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRI 227
I+LADEISPDTCR WDA+T + DKD+FR + G+L + YE++ RI
Sbjct: 187 AILLADEISPDTCRLWDAKTGERFDKDLFRRNLGNLQDGYEQILTRI 233
>pir||A81397 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC
6.3.2.6) Cj0512 [imported] - Campylobacter jejuni
(strain NCTC 11168) >gi|6967981|emb|CAB75149.1|
(AL139075)
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Campylobacter jejuni]
Length = 236
Score = 210 bits (530), Expect = 9e-54
Identities = 106/228 (46%), Positives = 149/228 (64%), Gaps = 3/228 (1%)
Query: 3 VYEGKAKKMIPMDDDKFIM-EFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+YEGK KK+ DD+ ++ EFKDD TAF+ K+ GKG LN +IS + F LLE++GI
Sbjct: 7 LYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCKISTEIFHLLEKNGI 66
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
KTH + + D + +V+K + P+EV+VRNV GSL KRL + +G LP +VE K D
Sbjct: 67 KTHLVEIISDTEQVVKKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEFCLKDDA 126
Query: 122 LHDPMINYYHAKILGITLEE--IKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKN 179
L DP IN H IL + E I +++ +A K+N IL + + + L+DFK+E G K+
Sbjct: 127 LGDPFINDEHCLILNLVQNEAQISEIKNMARKINSILTPFFDNKNLRLIDFKIELGLTKD 186
Query: 180 GEIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRI 227
E++LADEISPD+CRFWD + + LDKD FR D G++ AYEE+ +RI
Sbjct: 187 NELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRI 234
>sp|P73471|PUR7_SYNY3 PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|7437946|pir||S77408
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - Synechocystis sp. (strain PCC 6803)
>gi|1652590|dbj|BAA17511.1| (D90906) phosphoribosyl
aminoidazole succinocarboxamide synthetase
[Synechocystis sp.]
Length = 264
Score = 210 bits (528), Expect = 2e-53
Identities = 109/235 (46%), Positives = 159/235 (67%), Gaps = 6/235 (2%)
Query: 2 EVYEGKAKKMIPMDD-DKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
++YEGKAK + P +D D + FKDDATAF+ KK + +GKG +N ISA F+ LE G
Sbjct: 19 KLYEGKAKILYPTEDPDVLLTIFKDDATAFNAQKKGQIQGKGAINCAISAALFRWLETLG 78
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
I TH+I +++++V+ +++ PLEVVVRN+ AGSL K+ L EG LP P+VE Y+K D
Sbjct: 79 IPTHYIDCPQNDQMLVKAVNIIPLEVVVRNIAAGSLCKQTGLKEGLVLPNPLVEFYFKDD 138
Query: 121 ELHDPMINYYHAKILGITLE-EIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKN 179
L DP++ + A +LG+T E ++ ++++AL +N+ L+ + A+ I LVDFKLEFG ++
Sbjct: 139 ALGDPLLTWERALLLGVTDEARLQTLKDLALNINQHLQRFFAQCDITLVDFKLEFGGDRQ 198
Query: 180 GEIILADEISPDTCRFWD----AETKKSLDKDVFRFDKGDLIEAYEELYRRITGE 230
G+IILADEISPDTCR WD + LDKD FR D G + AY+ + +R+ +
Sbjct: 199 GKIILADEISPDTCRLWDNAQADPQARVLDKDRFRRDLGSIEAAYQTVEKRVLSQ 253
>sp|O26272|PUR7_METTH PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|7437945|pir||D69094
phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Methanobacterium thermoautotrophicum (strain Delta H)
>gi|2621212|gb|AAB84676.1| (AE000804)
phosphoribosylaminoimidazolesuccinocarboxamide synthase
[Methanobacterium thermoautotrophicum]
Length = 248
Score = 209 bits (526), Expect = 3e-53
Identities = 102/231 (44%), Positives = 153/231 (66%), Gaps = 2/231 (0%)
Query: 3 VYEGKAKKMIPMDDDKFI-MEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+Y GKAK ++ DD + + + F+DD TA DG KK + KG+ N+ ISAK F++LEE G+
Sbjct: 9 LYSGKAKDVLLTDDPEIVAVRFRDDITAGDGEKKDTLEMKGYYNSVISAKIFEVLEEAGV 68
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
T ++ + ++ KL+M P+EV+ RN+ AGS+ +R P EG E P++++ YKSDE
Sbjct: 69 PTQYLELREPGCILARKLEMIPIEVITRNIAAGSIVRRFPFTEGQEFVPPLIQMDYKSDE 128
Query: 122 LHDPMINYYHAKILGI-TLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
DPM+N LGI T +E++++ I L +N +L+D+L RG+IL DFKLEFG++ +G
Sbjct: 129 HGDPMLNDDIILALGIATRDELEEIRRITLHINSVLRDFLKSRGLILPDFKLEFGRDSSG 188
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRITGED 231
I L DE+SPDTCR WD ET + LDKD+FR + ++ AY + R I ++
Sbjct: 189 RIRLGDEVSPDTCRLWDMETGEPLDKDIFRRGEEGVVGAYRRVARMILDDE 239
>sp|Q07296|PUR7_STRPN PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|625868|pir||A36941
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - Streptococcus pneumoniae
>gi|295192|gb|AAA03540.1| (L15190) SAICAR synthetase
[Streptococcus pneumoniae] >gi|663281|gb|AAA69512.1|
(M36180) SAICAR synthetase [Streptococcus pneumoniae]
Length = 235
Score = 207 bits (521), Expect = 1e-52
Identities = 108/227 (47%), Positives = 151/227 (65%), Gaps = 3/227 (1%)
Query: 3 VYEGKAKKMIPMDDDKFIME-FKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+Y GKAK + +D+ I+ +KD ATAF+GVKK + GKG LN QIS+ F+ L G+
Sbjct: 6 IYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAGV 65
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
THF+ D + + +K+ + PLEVV+RN AGS KR + EG L PIVE YYK+D+
Sbjct: 66 ATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDD 125
Query: 122 LHDPMINYYHAKILGIT-LEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
L DP IN H K L I ++I ++E A ++NE+LK + A+ G+ L+DFKLEFG +K+G
Sbjct: 126 LDDPFINDEHVKFLQIADDQQIAYLKEEARRINELLKVWFAEIGLKLIDFKLEFGFDKDG 185
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRI 227
+IILADE SPD CR WDA+ +DKDVFR G+L + YE ++ ++
Sbjct: 186 KIILADEFSPDNCRLWDAD-GNHMDKDVFRRGLGELTDVYEIVWEKL 231
>pir||T51698 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC
6.3.2.6) [imported] - Lactococcus lactis
>gi|4097530|gb|AAD12623.1| (U64311)
phosphoribosylaminoimidazolesuccinocarboxamide
synthetase [Lactococcus lactis]
Length = 236
Score = 206 bits (518), Expect = 2e-52
Identities = 113/223 (50%), Positives = 148/223 (65%), Gaps = 3/223 (1%)
Query: 3 VYEGKAKKMIPMDDDKFI-MEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+YEGKAKK+ DD + +E+ D ATA +G +K + GKG LN QI++ F+ L G+
Sbjct: 7 LYEGKAKKLYFTDDSNVLWVEYCDQATALNGARKEQITGKGALNNQITSLIFEKLNAEGL 66
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
+THFI + + +K+ + PLEVV+RNVVAGS KR L EG L EPIVE YYK D
Sbjct: 67 ETHFIKKLSKTEQLNKKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLEEPIVEFYYKDDA 126
Query: 122 LHDPMINYYHAKILGITLE-EIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
L DP IN H K L I + EI+ +++ K+N+ILK + G+ LVDFKLEFG+ +G
Sbjct: 127 LDDPFINDEHVKFLNIASDSEIEFLKKETRKINKILKKIWTEIGLTLVDFKLEFGRLADG 186
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEEL 223
IILADEISPDT R WDA+ + +DKDVFR + GDLIE Y E+
Sbjct: 187 SIILADEISPDTSRLWDAK-GQHMDKDVFRRNIGDLIETYTEV 228
>gb|AAK40937.1| Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR
synthetase) (purC) [Sulfolobus solfataricus]
Length = 233
Score = 199 bits (502), Expect = 2e-50
Identities = 103/230 (44%), Positives = 154/230 (66%), Gaps = 5/230 (2%)
Query: 2 EVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
++ EGK K + D D ++EFKDD TA DG K+ +GKG LNAQ SA FF+LLE +GI
Sbjct: 5 KISEGKTKIVYDFDKDHVLLEFKDDITAGDGQKRDILEGKGVLNAQTSAFFFRLLERNGI 64
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
+TH++G+ + +IV+KL M P+EVV+RN+ GS+ KRLP+ EG PIVE + K D
Sbjct: 65 ETHYVGMKDERTMIVKKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFESPIVEFFLKDDL 124
Query: 122 LHDPMINYYHAKILGI-TLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
HDP++NYYH + L + +E + +E+I +KVN++L +++ +G IL DFKLEFG+
Sbjct: 125 RHDPLLNYYHMEHLKLMNRKEAQHIEDIMMKVNDVLFNFIKSKGFILYDFKLEFGR-LGD 183
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFR--FDKGDLIEAYEELYRRIT 228
++++ DEIS D+ R D + + DKD++R +D + +YEE +RIT
Sbjct: 184 KLVIGDEISLDSMRIRDGNS-RIYDKDLYRKGYDLKTVKSSYEEFLKRIT 232
>emb|CAB57674.1| (Y18930) phosphoribosylaminoimidazole-succinocarboxamide, synthase
(SAICAR synthetase) [Sulfolobus solfataricus]
Length = 233
Score = 199 bits (502), Expect = 2e-50
Identities = 103/230 (44%), Positives = 154/230 (66%), Gaps = 5/230 (2%)
Query: 2 EVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
++ EGK K + D D ++EFKDD TA DG K+ +GKG LNAQ SA FF+LLE +GI
Sbjct: 5 KISEGKTKIVYDFDKDHVLLEFKDDITAGDGQKRDILEGKGVLNAQTSAFFFRLLERNGI 64
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDE 121
+TH++G+ + +IV+KL M P+EVV+RN+ GS+ KRLP+ EG PIVE + K D
Sbjct: 65 ETHYVGMKDERTMIVKKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFESPIVEFFLKDDL 124
Query: 122 LHDPMINYYHAKILGI-TLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNG 180
HDP++NYYH + L + +E + +E+I +KVN++L +++ +G IL DFKLEFG+
Sbjct: 125 RHDPLLNYYHMEHLKLMNRKEAQHIEDIMMKVNDVLFNFIKSKGFILYDFKLEFGR-LGD 183
Query: 181 EIILADEISPDTCRFWDAETKKSLDKDVFR--FDKGDLIEAYEELYRRIT 228
++++ DEIS D+ R D + + DKD++R +D + +YEE +RIT
Sbjct: 184 KLVIGDEISLDSMRIRDGNS-RIYDKDLYRKGYDLKTVKSSYEEFLKRIT 232
>pir||F83520 phosphoribosylaminoimidazole-succinocarboxamide synthase PA1013
[imported] - Pseudomonas aeruginosa (strain PAO1)
>gi|9946923|gb|AAG04402.1|AE004533_13 (AE004533)
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Pseudomonas aeruginosa]
Length = 236
Score = 198 bits (498), Expect = 5e-50
Identities = 106/228 (46%), Positives = 146/228 (63%), Gaps = 3/228 (1%)
Query: 2 EVYEGKAKKMIPMDD-DKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
E+Y GKAK + DD D+ I+ F++D +AFDG + + KG +N + +A + LE G
Sbjct: 6 ELYRGKAKSVYQTDDADRLILLFRNDTSAFDGKRIEQLDRKGAVNNKFNAFIMQKLEAAG 65
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
I T F + D + +V+KLDM P+E VVRN AGSL +RL + EG L P EL+ K+D
Sbjct: 66 IPTQFDKLLSDTECLVKKLDMIPVECVVRNFAAGSLVRRLGVEEGIALTPPTFELFLKND 125
Query: 121 ELHDPMINYYHAKILG-ITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKN 179
L DP IN H + G T E++ +M+ + KVNE+L G++LVDFKLEFG +
Sbjct: 126 ALGDPFINESHVQAFGWATPEQLAQMKTYSFKVNEVLNKLFDDAGLLLVDFKLEFGL-FH 184
Query: 180 GEIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRI 227
G+I+L DE SPD CR WD ET+K +DKD FR GD+IEAYEE+ +R+
Sbjct: 185 GQIVLGDEFSPDGCRLWDKETRKKMDKDRFRQGLGDVIEAYEEVAKRL 232
>sp|P21155|PUR7_ECOLI PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|96295|pir||C36146
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - Escherichia coli
>gi|147410|gb|AAA24448.1| (M33928)
5'-phosphoribosyl-5-aminoimidazole-4-
N-succinocarboxamide synthetase (EC 6.3.2.6)
[Escherichia coli] >gi|1788820|gb|AAC75529.1| (AE000334)
phosphoribosylaminoimidazole-succinocarboxamide
synthetase = SAICAR synthetase [Escherichia coli K12]
>gi|1799903|dbj|BAA16353.1| (D90876)
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) [Escherichia coli]
>gi|1805534|dbj|BAA16363.1| (D90877)
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) [Escherichia coli]
Length = 237
Score = 192 bits (482), Expect = 4e-48
Identities = 101/228 (44%), Positives = 144/228 (62%), Gaps = 3/228 (1%)
Query: 2 EVYEGKAKKMIPMDD-DKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
E+Y GKAK + ++ D ++EF++D +A DG + +F KG +N + + L E G
Sbjct: 6 ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
I T + D + +V+KLDM P+E VVRN AGSL KRL + EG EL P+ +L+ K+D
Sbjct: 66 IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
Query: 121 ELHDPMINYYHAKILG-ITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKN 179
+HDPM+N + + G ++ E + +M+E+ K N++LK G+ILVDFKLEFG K
Sbjct: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK- 184
Query: 180 GEIILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRI 227
GE++L DE SPD R WD ET + +DKD FR G LIEAYE + RR+
Sbjct: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
>sp|Q9X0X0|PUR7_THEMA PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|7437948|pir||E72276
phosphoribosylaminoimidazole-succinocarboxamide synthase
- Thermotoga maritima (strain MSB8)
>gi|4981798|gb|AAD36318.1|AE001780_2 (AE001780)
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Thermotoga maritima]
Length = 230
Score = 171 bits (430), Expect = 5e-42
Identities = 98/221 (44%), Positives = 134/221 (60%), Gaps = 4/221 (1%)
Query: 4 YEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIKT 63
YEGK K ++ + D ++EFKDD TA DG+K GKG + A+ +A K L E GIKT
Sbjct: 3 YEGKTK-IVKVTGDYALLEFKDDITAGDGLKHDVLTGKGSICAETTAILMKYLSEKGIKT 61
Query: 64 HFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSDELH 123
H + L V L M+PLEVVVR AGS +R EG +LP P+VE + K DE H
Sbjct: 62 HLVEYIPPRTLKVIPLKMFPLEVVVRLKKAGSFVRRYGGAEGEDLPVPLVEFFIKDDERH 121
Query: 124 DPMINYYHAKILGI-TLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKNGEI 182
DPM+ H +ILGI T ++ +KM+E A+K+ LK++ + L D K EFG +K+G +
Sbjct: 122 DPMVCVDHLEILGIATKKQAEKMKEAAVKITLALKEFFERANFELWDIKYEFGLDKDGNV 181
Query: 183 ILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEEL 223
+L DEISPDT R + + DKDV+R D GD ++ Y E+
Sbjct: 182 VLGDEISPDTFRL--RKKGEIFDKDVYRRDLGDPLKKYREV 220
>sp|O05946|PUR7_RICPR PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|7437949|pir||D71733
phosphoribosylaminoimidazole-succinocarboxamide synthase
(purC) RP220 - Rickettsia prowazekii
>gi|2073474|emb|CAA72468.1| (Y11780)
Phosphoribosylaminoimidazole-succinocarboxamide synthase
[Rickettsia prowazekii] >gi|3860782|emb|CAA14683.1|
(AJ235270)
PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
(purC) [Rickettsia prowazekii]
Length = 236
Score = 125 bits (311), Expect = 5e-28
Identities = 72/231 (31%), Positives = 124/231 (53%), Gaps = 6/231 (2%)
Query: 2 EVYEGKAKKMIPMDDD-KFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
++YEG +K + ++D IM F D A G + GKG LN IS+ LE G
Sbjct: 4 KLYEGSSKILYSAEEDFLLIMAFSDKAVLETG-ETVDISGKGVLNNNISSFLMDKLEMIG 62
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKSD 120
I+ H I + +++ ++++P++V++ +V G K + EGY +PI++ +S
Sbjct: 63 IENHLIEKINMREQLIQYVEVFPIQVIISSVACGRFVKEFGMDEGYVFDKPIIDFKVRSR 122
Query: 121 ELHDPMINYYHAKILG-ITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEFGKNKN 179
E + P++N Y G +T++EI+ ++ L++ + L GI LV+ KLEFG+ N
Sbjct: 123 EFNYPIVNEYQISNFGWLTMDEIRIVKAQTLRIYDFLSGLFIGIGIRLVECKLEFGRVFN 182
Query: 180 GE---IILADEISPDTCRFWDAETKKSLDKDVFRFDKGDLIEAYEELYRRI 227
GE I+L DEISPD CR W + + L ++ + + E+Y+ + R+
Sbjct: 183 GEESIIMLTDEISPDNCRLWHINSNEKLGFELIQNEPNKAFESYQLIANRL 233
>gb|AAF53199.1| (AE003636) CG17024 gene product [Drosophila melanogaster]
Length = 395
Score = 120 bits (297), Expect = 2e-26
Identities = 76/216 (35%), Positives = 112/216 (51%), Gaps = 11/216 (5%)
Query: 5 EGKAKKMIPMDDDK--FIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
EGK KK+ + D ++ KD TAFDG+ + +GK ++ + F+LL E GI+
Sbjct: 17 EGKTKKVYDLPDHPGLCLLLSKDRITAFDGLMAHELQGKAAISNTTNGLVFRLLNEAGIR 76
Query: 63 THFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVELYYKSDE 121
T ++ GDN I K M +E V R + GS K P +PEGY P E +K D
Sbjct: 77 TAYVDQCGDNAFIARKCQMVHIEWVTRRLATGSFIKLNPEVPEGYRFAPPKQETCFKDDS 136
Query: 122 LHDP-------MINYYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEF 174
HDP + + + L I +E++ M +L V E+L+ + LVD K+EF
Sbjct: 137 SHDPLWCDEQILSSNFECNGLIIGADEVQIMRRTSLVVFEVLERAWKTKNCALVDMKVEF 196
Query: 175 GKNKNGEIILADEISPDTCRFWDAETKK-SLDKDVF 209
G +++G I+LAD I DT R W A K+ +DK V+
Sbjct: 197 GVDEDGNILLADIIDSDTWRIWPAGDKRLMVDKTVY 232
>gb|AAF06355.1|AF102579_1 (AF102579) 5'-phosphoribosylaminoimidazole
carboxylase-5'-phosphoribosyl-4-(N-succinocarboxamide)-
5-aminoimidazole synthetase [Drosophila melanogaster]
>gi|6273743|gb|AAF06356.1|AF102580_1 (AF102580)
5'-phosphoribosylaminoimidazole
carboxylase-5'-phosphoribosyl-4-(N-succinocarboxamide)-
5-aminoimidazole synthetase [Drosophila melanogaster]
Length = 429
Score = 115 bits (286), Expect = 4e-25
Identities = 75/219 (34%), Positives = 110/219 (49%), Gaps = 11/219 (5%)
Query: 3 VYEGKAKKM--IPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
+ EGK K++ +P ++ KD TA DGVK GK ++ + + F+LL E G
Sbjct: 18 IIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVFRLLNEAG 77
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGS-LKKRLPLPEGYELPEPIVELYYKS 119
I+T ++ G I K M P+E V R + GS LK+ + +PEGY P E ++K
Sbjct: 78 IRTAYVKQCGAKAFIARKCQMIPIEWVTRRLATGSFLKRNVGVPEGYRFSPPKQETFFKD 137
Query: 120 DELHDPMIN-------YYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKL 172
D HDP + + L I +E+ M L V EIL+ + L+D K+
Sbjct: 138 DANHDPQWSEEQIVSAKFELNGLVIGQDEVDIMRRTTLLVFEILERAWQTKNCALIDMKV 197
Query: 173 EFGKNKNGEIILADEISPDTCRFWDAETKK-SLDKDVFR 210
EFG +G I+LAD I D+ R W A K+ +DK V+R
Sbjct: 198 EFGICDDGNIVLADIIDSDSWRLWPAGDKRLMVDKQVYR 236
>gb|AAG22346.1| (AE003490) ade5 gene product [Drosophila melanogaster]
Length = 431
Score = 110 bits (273), Expect = 1e-23
Identities = 75/221 (33%), Positives = 110/221 (48%), Gaps = 13/221 (5%)
Query: 3 VYEGKAKKM--IPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEH- 59
+ EGK K++ +P ++ KD TA DGVK GK ++ + + F+LL E
Sbjct: 18 IIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVFRLLNEAA 77
Query: 60 -GIKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGS-LKKRLPLPEGYELPEPIVELYY 117
GI+T ++ G I K M P+E V R + GS LK+ + +PEGY P E ++
Sbjct: 78 TGIRTAYVKQCGAKAFIARKCQMIPIEWVTRRLATGSFLKRNVGVPEGYRFSPPKQETFF 137
Query: 118 KSDELHDPMINY-------YHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDF 170
K D HDP + + L I +E+ M L V EIL+ + L+D
Sbjct: 138 KDDANHDPQWSEEQIVSAKFELNGLVIGQDEVDIMRRTTLLVFEILERAWQTKNCALIDM 197
Query: 171 KLEFGKNKNGEIILADEISPDTCRFWDAETKK-SLDKDVFR 210
K+EFG +G I+LAD I D+ R W A K+ +DK V+R
Sbjct: 198 KVEFGICDDGNIVLADIIDSDSWRLWPAGDKRLMVDKQVYR 238
>gi|5453539 multifunctional polypeptide similar to SAICAR synthetase and AIR
carboxylase [Homo sapiens]
>gi|131628|sp|P22234|PUR6_HUMAN MULTIFUNCTIONAL PROTEIN
ADE2 [INCLUDES:
PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
(SAICAR SYNTHETASE); PHOSPHORIBOSYLAMINOIMIDAZOLE
CARBOXYLASE (AIR CARBOXYLASE) (AIRC)]
>gi|106347|pir||S14147 multifunctional purine
biosynthesis protein - human >gi|28384|emb|CAA37801.1|
(X53793) 5' half of the product is homologues to
Bacillus subtiis SAICAR synthetase, 3' half corresponds
to the catalytic subunit of AIR carboxylase [Homo
sapiens]
Length = 425
Score = 109 bits (270), Expect = 3e-23
Identities = 74/222 (33%), Positives = 115/222 (51%), Gaps = 14/222 (6%)
Query: 2 EVYEGKAKKMIPMDDD--KFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEH 59
++YEGK K++ + D K +++ KD TA + +K +GK ++ +I++ F+LL+E
Sbjct: 12 KLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEA 71
Query: 60 GIKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVELYYK 118
GIKT F G+ I + +M P+E V R + GS KR P + EGY+ P VEL++K
Sbjct: 72 GIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFK 131
Query: 119 SDELHDPM--------INYYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDF 170
D +DP + A +L I E+ M + EIL+ + LVD
Sbjct: 132 DDANNDPQWSEEQLIAAKFCFAGLL-IGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDM 190
Query: 171 KLEFGKN-KNGEIILADEISPDTCRFW-DAETKKSLDKDVFR 210
K+EFG + EI+LAD I D+ R W + + DK +R
Sbjct: 191 KIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYR 232
>sp|Q10457|PUR6_CAEEL PROBABLE MULTIFUNCTIONAL PROTEIN ADE2 [INCLUDES:
PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
(SAICAR SYNTHETASE); PHOSPHORIBOSYLAMINOIMIDAZOLE
CARBOXYLASE (AIR CARBOXYLASE) (AIRC)]
>gi|7494835|pir||T15309 hypothetical protein B0286.3 -
Caenorhabditis elegans >gi|1053219|gb|AAA80690.1|
(U39848) Contains similarity to Pfam domain: PF01259
(SAICAR_synt), Score=452.5, E-value=1.2e-132, N=1
[Caenorhabditis elegans]
Length = 423
Score = 107 bits (265), Expect = 1e-22
Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 15/229 (6%)
Query: 5 EGKAKKMIPMDDDK--FIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
EGK K++ + +K ++ KD TAF+ V+K + +GK + ++ ++ F+ L+ G+
Sbjct: 19 EGKTKQIFDIKGEKDYVLIRSKDSLTAFNAVRKNELEGKSRIASKTTSNVFEYLQLLGLP 78
Query: 63 THFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVELYYKSDE 121
THF + + + K M P+E V R V GS KR P + EG+ + +E ++K D
Sbjct: 79 THFEKSISETEFVARKCTMIPIEWVARRVATGSFLKRNPGVKEGFRFNDLKLETFFKDDA 138
Query: 122 LHDP-------MINYYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVDFKLEF 174
DP + N L I EEI M+++ V L+ A L+D K+EF
Sbjct: 139 NDDPQWTDEQIVSNGLMIDHLKIGREEISLMKKMTKLVFRALEKGWALSNSALIDMKIEF 198
Query: 175 GKNKNGEIILADEISPDTCRFW-DAETKKSLDKDVFRFDKGDLIEAYEE 222
G GEI+LAD I D+ R W + + + LDK V+R D+ E EE
Sbjct: 199 GVTVEGEILLADVIDNDSWRVWPENDRRLQLDKQVYR----DMKEVTEE 243
>sp|P51583|PUR6_RAT MULTIFUNCTIONAL PROTEIN ADE2 [INCLUDES:
PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
(SAICAR SYNTHETASE); PHOSPHORIBOSYLAMINOIMIDAZOLE
CARBOXYLASE (AIR CARBOXYLASE) (AIRC)]
>gi|1363267|pir||S55684 aminoimidazole ribonucleotide
carboxylase - rat >gi|976252|dbj|BAA07197.1| (D37979)
AIR carboxylase-SAICAR synthetase [Rattus norvegicus]
>gi|1096145|prf||2111238A aminoimidazole ribonucleotide
carboxylase [Rattus norvegicus]
Length = 425
Score = 107 bits (264), Expect = 1e-22
Identities = 71/223 (31%), Positives = 115/223 (50%), Gaps = 16/223 (7%)
Query: 2 EVYEGKAKKMIPMDDD--KFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEH 59
++YEGK K++ + D + +++ KD TA + +K +GK ++ +I++ F+LL+E
Sbjct: 12 KLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEA 71
Query: 60 GIKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVELYYK 118
GIKT F G+ I + +M P+E V R + GS KR P + EGY P VE+++K
Sbjct: 72 GIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEMFFK 131
Query: 119 SDELHDPMIN---------YYHAKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILVD 169
D +DP + + ++G T E+ M + EIL+ + LVD
Sbjct: 132 DDANNDPQWSEEQLIAAKFCFAGLVIGQT--EVDIMSHATQAIFEILEKSWLPQNCTLVD 189
Query: 170 FKLEFGKN-KNGEIILADEISPDTCRFW-DAETKKSLDKDVFR 210
K+EFG + EI+LAD I D+ R W + + DK +R
Sbjct: 190 MKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYR 232
>sp|P38024|PUR6_CHICK MULTIFUNCTIONAL PROTEIN ADE2 [INCLUDES:
PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
(SAICAR SYNTHETASE); PHOSPHORIBOSYLAMINOIMIDAZOLE
CARBOXYLASE (AIR CARBOXYLASE) (AIRC)]
>gi|104510|pir||A35641 5-aminoimidazole ribonucleotide
carboxylase-5-aminoimidazole-4-N-succinocarboxamide
ribonucleotide - chicken >gi|211194|gb|AAA48601.1|
(M31764) 5-aminoimidazole ribonucleotide (AIR)
carboxylase-5- aminoimidazole-4-N-succinocarboxamide
ribonucleotide (SAICAR) synthetase [Gallus gallus]
Length = 426
Score = 106 bits (262), Expect = 3e-22
Identities = 78/236 (33%), Positives = 119/236 (50%), Gaps = 12/236 (5%)
Query: 2 EVYEGKAKKMIPMDDDK--FIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEH 59
+V EGK K++ + D +M+ KD TA + +K + +GK ++ ++ F+LL+E
Sbjct: 13 KVNEGKTKEVYELPDIPGCVLMQSKDQITAGNAARKDRMEGKAAISNTTTSCVFQLLQEA 72
Query: 60 GIKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVELYYK 118
GIKT F+ D I +M P+E V R + GS KR P + EGY+ P +E++YK
Sbjct: 73 GIKTAFVRKQSDTAFIAAHCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKIEMFYK 132
Query: 119 SDELHDPMIN---YYHAK--ILGITL--EEIKKMEEIALKVNEILKDYLAKRGIILVDFK 171
D +DP + AK G+T+ E+ M + EIL+ + LVD K
Sbjct: 133 DDANNDPQWSEEQLIEAKFSFAGLTIGKTEVDIMARSTQAIFEILEKSWQPQNCTLVDLK 192
Query: 172 LEFGKN-KNGEIILADEISPDTCRFW-DAETKKSLDKDVFRFDKGDLIEAYEELYR 225
+EFG N EI+LAD I D+ R W + + DK +R K EA + + R
Sbjct: 193 IEFGVNILTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEALQMVKR 248
>emb|CAC11454.1| (AL445063) phosphoribosylamidoimidazole-succinocarboxamide synthase
related protein [Thermoplasma acidophilum]
Length = 314
Score = 93.2 bits (228), Expect = 2e-18
Identities = 71/252 (28%), Positives = 121/252 (47%), Gaps = 40/252 (15%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
+ +GK K + D D + F + + FD + + + KG + S+ +F+ + E GIK
Sbjct: 24 IAKGKVKDVYD-DGDTLVFRFSNRISVFDKIIPTEIENKGESLCRTSSFWFRYIGERGIK 82
Query: 63 THFIGVAGDNKLIVEKLDM------------YPLEVVVRNVVAGSLKKRLP--------- 101
HFI + + + V K D+ PLE + R+ VAGSL RL
Sbjct: 83 NHFIEMIDNRTMRVRKYDVPEKVSPGSSGYVIPLEFITRHYVAGSLYDRLKAGSTKPADI 142
Query: 102 ----LPE-GYELPEPIVELYYKSDELHDPMINYYHA-KILGITLEEIKKMEEIALKVNEI 155
P+ G +LP P+ E+ K ++ D +++ A +I G+T EE ++ E LK++E+
Sbjct: 143 GLNHFPDYGEKLPSPVFEVTTKREKT-DRLLDIDEALEISGLTREEYAEIRETILKIDEM 201
Query: 156 LKDYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAETKKSLDKDVFRFDKG 214
++ + KRG+I D K E K E I+ D + D RFW+ + +D G
Sbjct: 202 MEQEVGKRGLIHADGKKEVALGKEREPIIVDTFGTADEDRFWEKK----------EYDAG 251
Query: 215 DLIEAYEELYRR 226
++E +E+ R+
Sbjct: 252 RIVELSKEMVRQ 263
>sp|O68830|PUR7_LACLA PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|3005671|gb|AAC32329.1| (AF054888)
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Lactococcus lactis]
Length = 115
Score = 92.8 bits (227), Expect = 3e-18
Identities = 50/109 (45%), Positives = 69/109 (62%), Gaps = 1/109 (0%)
Query: 3 VYEGKAKKMIPMDDDKFI-MEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+YEGKAKK+ DD + + +E+ D ATA +G +K + GKG LN QI++ F+ L G+
Sbjct: 7 LYEGKAKKLYFTDDSEVLWVEYCDQATALNGARKEQITGKGALNNQITSLIFEKLNAEGL 66
Query: 62 KTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPE 110
+THFI + + K+ + PLEVV+RNVVAGS KR L EG L E
Sbjct: 67 ETHFIEKLSKTEQLNRKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLQE 115
>sp|P50124|PUR7_PICJA PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|543485|pir||JC2039
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - yeast (Pichia jadinii)
>gi|391937|dbj|BAA04175.1| (D17356)
phosphoribosylaminoimidazolesuccinocarboxamide
synthetase [Candida utilis] >gi|740931|prf||2006225A
phosphoribosylaminoimidazolesuccinocarboxamide
synthetase [Pichia jadinii]
Length = 301
Score = 92.1 bits (225), Expect = 5e-18
Identities = 73/248 (29%), Positives = 116/248 (46%), Gaps = 42/248 (16%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
V GK + + +D+ + D +A+D + + KG L Q+S +F+ L+ + IK
Sbjct: 15 VARGKVRDIYEVDEKTLLFVATDRISAYDVIMENGIPQKGQLLTQLSEFWFEFLKPY-IK 73
Query: 63 THFIGVAG-------------------DNKLIVEKLDMYPLEVVVRNVVAGS-------- 95
TH I V L+V K + PLEV+VR + GS
Sbjct: 74 THLIEVDDIFAHLPKVLSEDRYKSQLQGGSLLVRKYKLVPLEVIVRGYITGSAWKVYKKS 133
Query: 96 -----LKKRLPLPEGYELPEPIVELYYKSDE-LHDPMINYYHAKILGITLEEIKKMEEIA 149
+K L E E P PI K+++ HD I+ A+ + + E K+ ++A
Sbjct: 134 GTVHGVKAAEGLQESQEFPTPIFTPSTKAEQGEHDENISVEQAEAI-VGKELADKIGKVA 192
Query: 150 LKVNEILKDYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAET------KK 202
+++ K Y A RGII+ D K EFG + + E++L DE+ +PD+ RFW+A+T +
Sbjct: 193 VELYSKAKGYAAGRGIIIADTKFEFGLDDDNELVLVDEVLTPDSSRFWNAKTYEVGKGQD 252
Query: 203 SLDKDVFR 210
S DK R
Sbjct: 253 SYDKQFLR 260
>gi|6319326 phosphoribosyl amino imidazolesuccinocarbozamide synthetase; Ade1p
[Saccharomyces cerevisiae] >gi|2144564|pir||JQ1395
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - yeast (Saccharomyces cerevisiae)
>gi|170999|gb|AAA34398.1| (M67445)
phosphoribosyl-amino-imidazolesuccinocarboxamide
synthetase [Saccharomyces cerevisiae]
>gi|349755|gb|AAC04963.1| (L22015) Ade1p: phosphoribosyl
amino imidazolesuccinocarbozamide synthetase
[Saccharomyces cerevisiae]
Length = 306
Score = 91.3 bits (223), Expect = 9e-18
Identities = 75/253 (29%), Positives = 118/253 (45%), Gaps = 48/253 (18%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
V GK + + +D + D +A+D + + KG L ++S +FK L + ++
Sbjct: 15 VARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVR 73
Query: 63 THFIGVAG----------------------DNKLIVEKLDMYPLEVVVRNVVAGS----- 95
H + +A D L+V K + PLEV+VR + GS
Sbjct: 74 NHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEY 133
Query: 96 --------LKKRLPLPEGYELPEPIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKM 145
LK+ L E E PEPI K+++ HD I+ A +++G L +++
Sbjct: 134 VKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLS--RRV 191
Query: 146 EEIALKVNEILKDYLAKRGIILVDFKLEFG-KNKNGEIILADEI-SPDTCRFWD------ 197
E+A+K+ KDY ++GII+ D K EFG K EIIL DE+ +PD+ RFW+
Sbjct: 192 AELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKV 251
Query: 198 AETKKSLDKDVFR 210
E++ S DK R
Sbjct: 252 GESQDSYDKQFLR 264
>pdb|1A48| Saicar Synthase
Length = 306
Score = 91.3 bits (223), Expect = 9e-18
Identities = 75/253 (29%), Positives = 118/253 (45%), Gaps = 48/253 (18%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
V GK + + +D + D +A+D + + KG L ++S +FK L + ++
Sbjct: 15 VARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVR 73
Query: 63 THFIGVAG----------------------DNKLIVEKLDMYPLEVVVRNVVAGS----- 95
H + +A D L+V K + PLEV+VR + GS
Sbjct: 74 NHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEY 133
Query: 96 --------LKKRLPLPEGYELPEPIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKM 145
LK+ L E E PEPI K+++ HD I+ A +++G L +++
Sbjct: 134 VKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLS--RRV 191
Query: 146 EEIALKVNEILKDYLAKRGIILVDFKLEFG-KNKNGEIILADEI-SPDTCRFWD------ 197
E+A+K+ KDY ++GII+ D K EFG K EIIL DE+ +PD+ RFW+
Sbjct: 192 AELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKV 251
Query: 198 AETKKSLDKDVFR 210
E++ S DK R
Sbjct: 252 GESQDSYDKQFLR 264
>sp|P27616|PUR7_YEAST PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|170996|gb|AAA34396.1| (M61209)
N-succinyl-5-aminoimidazole-4-carboxamide ribotide
synthetase [Saccharomyces cerevisiae]
Length = 306
Score = 90.9 bits (222), Expect = 1e-17
Identities = 75/253 (29%), Positives = 118/253 (45%), Gaps = 48/253 (18%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
V GK + + +D + D +A+D + + KG L ++S +FK L + ++
Sbjct: 15 VARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVR 73
Query: 63 THFIGVAG----------------------DNKLIVEKLDMYPLEVVVRNVVAGS----- 95
H + +A D L+V K + PLEV+VR + GS
Sbjct: 74 NHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEY 133
Query: 96 --------LKKRLPLPEGYELPEPIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKM 145
LK+ L E E PEPI K+++ HD I+ A +++G L +++
Sbjct: 134 VKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGGDLS--RRV 191
Query: 146 EEIALKVNEILKDYLAKRGIILVDFKLEFG-KNKNGEIILADEI-SPDTCRFWD------ 197
E+A+K+ KDY ++GII+ D K EFG K EIIL DE+ +PD+ RFW+
Sbjct: 192 AELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKV 251
Query: 198 AETKKSLDKDVFR 210
E++ S DK R
Sbjct: 252 GESQDSYDKQFLR 264
>sp|P43851|PUR7_HAEIN PUTATIVE PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
(SAICAR SYNTHETASE) >gi|1075294|pir||E64138
phosphoribosylaminoimidazolesuccinocarboxamide synthase
homolog - Haemophilus influenzae (strain Rd KW20)
>gi|1574582|gb|AAC23372.1| (U32845)
phosphoribosylaminoimidazole-succinocarboxamide synthase
(purC) [Haemophilus influenzae Rd]
Length = 306
Score = 87.0 bits (212), Expect = 2e-16
Identities = 70/228 (30%), Positives = 108/228 (46%), Gaps = 32/228 (14%)
Query: 2 EVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
++Y GK + + +DD + +M D +AFD + KG + QIS +F L H +
Sbjct: 28 KIYSGKVRDLYEIDDKRMLMVTSDRLSAFDVILDDPIPRKGEILTQISNFWFNKLA-HIM 86
Query: 62 KTHFIG-------------VAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKR--------- 99
HF G + D ++ ++L+ +E +VR + GS K
Sbjct: 87 PNHFTGDSVYDVLPKEEADLIRDRAVVCKRLNPIKIESIVRGYLTGSGLKDYKQTGTICG 146
Query: 100 LPLPEGY----ELPEPIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKMEEIALKVN 153
L LPEG +LPE I K + HD I+Y K++G L K + IAL
Sbjct: 147 LKLPEGLVEASKLPEAIFTPSSKEEVGNHDINISYAECEKLIGADLAAQVKEKAIALYT- 205
Query: 154 EILKDYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAET 200
+ +Y +GII+ D K EFG ++NG + L DE+ +PD+ RFW +T
Sbjct: 206 -VAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDT 252
>pir||B81161 phosphoribosylaminoimidazole-succinocarboxamide synthase NMB0757
[imported] - Neisseria meningitidis (group B strain
MD58) >gi|7225987|gb|AAF41170.1| (AE002430)
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Neisseria meningitidis MC58]
Length = 287
Score = 87.0 bits (212), Expect = 2e-16
Identities = 72/245 (29%), Positives = 115/245 (46%), Gaps = 38/245 (15%)
Query: 1 MEVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
+++Y GK + + +DD + +M D +AFD + KG + QIS +FK L H
Sbjct: 7 VKIYFGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFKKLA-HI 65
Query: 61 IKTHFIG-----VAGDNK--------LIVEKLDMYPLEVVVRNVVAGSLKKR-------- 99
+ HF G V +N+ ++ +KL +E +VR +AGS K
Sbjct: 66 MPNHFTGQTVYDVLPENEAKALEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQKTGSVC 125
Query: 100 -LPLPEGYELPEPIVELYYKSDEL-----HDPMINYYHA-KILGITLEEIKKMEEIALKV 152
+ LPEG + + + E+ + HD I++ +I+G L E + + + L
Sbjct: 126 GIQLPEGMQEAQQLPEVIFTPSTKAAVGDHDENISFEECGRIIGKELAEEVRAKAVRLYT 185
Query: 153 NEILKDYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAETKK------SLD 205
+Y RGII+ D K EFG ++NG + L DE+ +PD+ RFW A+ K S D
Sbjct: 186 EAA--EYAKSRGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWPADQYKVGTNPPSFD 243
Query: 206 KDVFR 210
K R
Sbjct: 244 KQFVR 248
>pir||G81943 probable phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) NMA0968 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7379671|emb|CAB84238.1|
(AL162754) putative
phosphoribosylaminoimidazole-succinocarboxamide synthase
[Neisseria meningitidis Z2491]
Length = 287
Score = 85.8 bits (209), Expect = 4e-16
Identities = 66/228 (28%), Positives = 108/228 (46%), Gaps = 32/228 (14%)
Query: 1 MEVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
+++Y GK + + +DD + +M D +AFD + KG + QIS +FK L H
Sbjct: 7 VKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFKKL-AHI 65
Query: 61 IKTHFIG-------------VAGDNKLIVEKLDMYPLEVVVRNVVAGSLKK--------- 98
+ HF G V ++ +KL +E +VR +AGS K
Sbjct: 66 MPNHFTGQTVYDVLPENEAKVLEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQKTGSVC 125
Query: 99 RLPLPEGYELPEPIVELYYKSDEL-----HDPMINYYH-AKILGITLEEIKKMEEIALKV 152
+ LPEG + + + E+ + HD I++ +I+G L E ++ A+++
Sbjct: 126 GIRLPEGMQEAQQLPEVIFTPSTKAAVGDHDENISFEECGRIIGKELAE--EVRAKAVRL 183
Query: 153 NEILKDYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAE 199
+Y RGII+ D K EFG + NG + L DE+ +PD+ RFW A+
Sbjct: 184 YTEAAEYAKSRGIIICDTKFEFGLDTNGTLTLMDEVLTPDSSRFWPAD 231
>gb|AAF97181.1|AF268611_4 (AF268611) SAICAR synthase [uncultured marine group II
euryarchaeote 37F11]
Length = 301
Score = 85.8 bits (209), Expect = 4e-16
Identities = 69/255 (27%), Positives = 116/255 (45%), Gaps = 42/255 (16%)
Query: 3 VYEGKAKKMIPMDDDKFI-MEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGI 61
+Y+GK K++ DD + F + + FD + + KG + +A +FKL+E+ G+
Sbjct: 5 LYQGKVKQVWSTDDPDILEFRFTNQISVFDQIIPSLIPRKGESLNRTTAHWFKLVEQEGV 64
Query: 62 -KTHFIGVAGDNKLIVEKLDMY---------------PLEVVVRNVVAGSLKKRLPLPE- 104
TH + + ++ +V K+++ PLE +VR+ ++GS +R E
Sbjct: 65 CGTHLVELNAPDRCLVRKVEVVKEPGAIPRDAEWVFVPLEFIVRHYLSGSAWRRFQRGEL 124
Query: 105 -------------GYELPEPIVELYYKSDELHDPMINYYHAKILGITLEEIKKMEEIALK 151
G +L EP VE+ K + + +I IT +E + + ALK
Sbjct: 125 TAESLGVSQDAEYGVKLSEPFVEVTTKFEAFDRNIDREEALQISNITDQEFDSIVQAALK 184
Query: 152 VNEILKDYLAKRGIILVDFKLEFGKNKNGEIILADEISP-DTCRFWDAETKKSLDKDVFR 210
V+EI++ AK G+I VD K EF +++L D D R+WDAE
Sbjct: 185 VDEIIEREAAKNGLIHVDGKKEFALGPGRKVVLVDTFGTLDEDRWWDAEA---------- 234
Query: 211 FDKGDLIEAYEELYR 225
+ G+ IE +E R
Sbjct: 235 YSNGECIELSKEFVR 249
>dbj|BAA89448.1| (AB003161) 5'-phosphoribosyl-4-N-succinocarboxamide-5-amino
imidazole synth etase [Corynebacterium ammoniagenes]
Length = 295
Score = 83.1 bits (202), Expect = 3e-15
Identities = 65/238 (27%), Positives = 108/238 (45%), Gaps = 34/238 (14%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
V GK + + +DD+ +M D +A+D + KG + + FF ++
Sbjct: 11 VSSGKVRDIYEVDDNTLLMVVTDRISAYDFALEPAIPDKGRVLTATTMFFFDAID---FP 67
Query: 63 THFIGVAGDNKL---------IVEKLDMYPLEVVVRNVVAGSLKKR---------LPLPE 104
H G D ++ IV+KL+M P E V R + GS K + LPE
Sbjct: 68 NHLAGPIDDARIPEEVLGRAIIVKKLNMLPFECVARGYLTGSGLKEYNANGTVCGIELPE 127
Query: 105 GY----ELPEPIVELYYKSDEL-HDPMINYYHAKILGITLEEIKKMEEIALKVNEILKDY 159
G LPEPI K+++ HD +++ + + E +++ + L++
Sbjct: 128 GLVEASRLPEPIFTPATKAEQGDHDENVSFERV-VQDLGQERAEQLRDETLRIYSAAAKI 186
Query: 160 LAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAET------KKSLDKDVFR 210
++GIIL D K EFG + G ++L DE+ +PD+ R+W A+T + S DK R
Sbjct: 187 AEEKGIILADTKFEFGLDSEGNLVLGDEVLTPDSSRYWPADTYAEGIVQPSFDKQYVR 244
>gb|AAC15763.1| (AF060796) putative multifunctional protein ADE2 [Manduca sexta]
Length = 141
Score = 80.8 bits (196), Expect = 1e-14
Identities = 46/126 (36%), Positives = 69/126 (54%), Gaps = 3/126 (2%)
Query: 3 VYEGKAKKMIPMDD--DKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHG 60
+ EGK K++ + D ++ ++ KD TA DGVK +GK ++ Q +AK F +L G
Sbjct: 16 IIEGKTKQVFDLPDVPNQCMLINKDRITAGDGVKAHDMEGKAAISNQTNAKVFNILNSAG 75
Query: 61 IKTHFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKRLP-LPEGYELPEPIVELYYKS 119
IKT F+ + I +K +M P+E V R + GS KR P +PEG+ P E ++K
Sbjct: 76 IKTAFVKMVSPTAFISKKCEMVPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKD 135
Query: 120 DELHDP 125
D DP
Sbjct: 136 DANLDP 141
>sp|O08361|PUR7_MYCLE PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|2076622|emb|CAB08411.1| (Z95151) PurC
[Mycobacterium leprae]
Length = 297
Score = 78.8 bits (191), Expect = 5e-14
Identities = 75/278 (26%), Positives = 124/278 (43%), Gaps = 59/278 (21%)
Query: 6 GKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIKTHF 65
GK +++ +DD+ +M D +AFD V + KG + +S FF ++ H
Sbjct: 14 GKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKGRILTAMSVFFFSFVDA---PNHL 70
Query: 66 IGVAGDNK---------LIVEKLDMYPLEVVVRNVVAGS---------LKKRLPLPEGY- 106
G D + L+V +LDM P+E V R + GS +PLP G
Sbjct: 71 AGPPDDPRIPEEVLGRALVVRQLDMLPMECVARGYLTGSGLLDYQATGKVCGIPLPPGLV 130
Query: 107 ELPEPIVELYYKSDEL----HDPMINYYHA-KILGITLEEIKKMEEIALKVNEILKDYLA 161
E L+ + + HD I++ +++G+ ++ + L++ D+
Sbjct: 131 EASRFAAPLFTPAMKAVLGEHDENISFSRMIEMVGVV--RANQLRDRTLQIYLQAADHAL 188
Query: 162 KRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAE------TKKSLDKDVFRF--- 211
K GII+ D K EFG +++G ++LADEI +PD+ R+W + ++S DK R
Sbjct: 189 KTGIIIADTKFEFGIDRDGNLLLADEIFTPDSSRYWSVDDYRVGVVQRSFDKQFVRNWLV 248
Query: 212 --DKG--------------DLIEA----YEELYRRITG 229
+ G D+IEA Y E+Y RI+G
Sbjct: 249 SPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISG 286
>pir||T40437 phosphoribosylamidoimidazole-succinocarboxamide synthase - fission
yeast (Schizosaccharomyces pombe)
>gi|5731917|emb|CAB52612.1| (AL109822)
phosphoribosylamidoimidazole-succinocarboxamide
synthase; SAICAR synthetase [Schizosaccharomyces pombe]
Length = 299
Score = 78.4 bits (190), Expect = 7e-14
Identities = 76/269 (28%), Positives = 124/269 (45%), Gaps = 59/269 (21%)
Query: 17 DKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIKTHFIGVAG------ 70
D + D +A+D + + KG + +IS +F +L+ H ++TH I
Sbjct: 31 DDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPH-VQTHLITSRWEELPPV 89
Query: 71 --------DNKLIVEKLDMYPLEVVVRNVVAGSLKKR---------LPLPEGYE----LP 109
D ++V+K + P+E +VR + GS K L +P G + P
Sbjct: 90 ITKHEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLNVPTGMKEAEAFP 149
Query: 110 EPIVELYYKSDELHDPMINYYH-AKILGITLEEIKKMEEIALKVNEILKDYLAKRGIILV 168
EP+ K+ E HD I+ +KI+G L K++ E ++K+ +I +D K+GII+
Sbjct: 150 EPLFTPSTKAAEGHDENIHPDEVSKIVGPELA--KQVAETSVKLYKIARDVALKKGIIIA 207
Query: 169 DFKLEFGKNK-NGEIILADEI-SPDTCRFWDAETKKSLDKDVFRFDK------------- 213
D K EFG ++ +I+L DE+ +PD+ RFW A + ++ K FDK
Sbjct: 208 DTKFEFGVDETTNKIVLVDEVLTPDSSRFWLA-SDYTVGKSPDSFDKQYLRNWLTANNLA 266
Query: 214 --------GDLIEA----YEELYRRITGE 230
D++EA Y E Y ITG+
Sbjct: 267 NKPNVSLPEDVVEATRRKYVEAYEMITGK 295
>sp|P27602|PUR7_CANMA PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|83924|pir||JH0489
phosphoribosylaminoimidazolesuccinocarboxamide synthase
(EC 6.3.2.6) - yeast (Candida maltosa)
>gi|170816|gb|AAA34318.1| (M58322)
phosphoribosyl-amidoimidazole-succinocarboxamide
synthetase [Candida maltosa] >gi|218521|dbj|BAA00731.1|
(D00855) C-ADE1 [Candida maltosa]
Length = 291
Score = 77.6 bits (188), Expect = 1e-13
Identities = 66/236 (27%), Positives = 113/236 (46%), Gaps = 28/236 (11%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLL--EEHG 60
+ +GK + + +DD+ + D +A+D + KG + ++S +F L E H
Sbjct: 13 IAKGKVRDIYQVDDNTLLFVATDRISAYDVIMSNGIPNKGKILTKLSEFWFDFLPIENHL 72
Query: 61 IKTHFI----------GVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKR---------LP 101
IK L+V KL + PLEV+VR + GS K +P
Sbjct: 73 IKGDIFQKYPQLEPYRNQLEGRSLLVRKLKLIPLEVIVRGYITGSGWKEYQKSKTVHGIP 132
Query: 102 LPEGYELPE--PIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKMEEIALKVNEILK 157
+ + E + PI K+++ HD I A KI+G L + ++E+IA+ + +
Sbjct: 133 IGDVVESQQITPIFTPSTKAEQGEHDENITKEQADKIVGKELCD--RIEKIAIDLYTKAR 190
Query: 158 DYLAKRGIILVDFKLEFGKNKNGEIILADEISPDTCRFWDAETKKSLDKDVFRFDK 213
DY A +GII+ D K EFG + + +++ + ++PD+ RFW+A K + K +DK
Sbjct: 191 DYAATKGIIIADTKFEFGLDGDNIVLVDEVLTPDSSRFWNA-AKYEVGKSQDSYDK 245
>sp|P43060|PUR7_CANAL PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|295566|gb|AAA34317.1| (L12463)
phosphoribosyl-amidoimidazole-succinocarboxamide
synthetase [Candida albicans]
Length = 291
Score = 75.7 bits (183), Expect = 5e-13
Identities = 69/240 (28%), Positives = 116/240 (47%), Gaps = 35/240 (14%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLL--EEHG 60
+ GK + + +DD+ + D +A+D + KG + ++S +F L + H
Sbjct: 13 IARGKVRDIYQVDDNTLLFVATDRISAYDVIMANGIPNKGKILTKLSEFWFAFLPIDNHL 72
Query: 61 IK----------THFIGVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKR---------LP 101
IK + L+V KL + PLEV+VR + GS K +P
Sbjct: 73 IKGDIFEKYPQLEKYRDQLEGRSLLVRKLKLIPLEVIVRGYITGSGWKEYTKSKTVHGIP 132
Query: 102 LPEGYELPE--PIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKMEEIALKVNEILK 157
+ + E + PI K+++ HD I A KI+G L + ++E+IA+ + +
Sbjct: 133 IGDVVESQQITPIFTPSTKAEQGEHDENITKEQADKIVGKELCD--RIEKIAIDLYTKAR 190
Query: 158 DYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDA------ETKKSLDKDVFR 210
DY A +GII+ D K EFG + + +I+L DE+ +PD+ RFW A ++++S DK R
Sbjct: 191 DYAATKGIIIADTKFEFGLDGD-KIVLVDEVLTPDSSRFWSAAKYKLGQSQESYDKQFLR 249
>pir||S55293 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC
6.3.2.6) (clone CipA10) - yeast (Candida maltosa)
Length = 291
Score = 75.3 bits (182), Expect = 6e-13
Identities = 74/277 (26%), Positives = 124/277 (44%), Gaps = 51/277 (18%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLL--EEHG 60
+ +GK + + +DD+ + D +A+D + KG + + S +F L E H
Sbjct: 13 IAKGKVRDINQVDDNTLLFVATDRISAYDVIMSNGIPNKGKILTKFSEFWFDFLPIENHL 72
Query: 61 IKTHFI----------GVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKR---------LP 101
IK L+V KL + PLEV+VR + GS K +P
Sbjct: 73 IKGDIFQKYPQLEPYRNQLEGRSLLVRKLKLIPLEVIVRGYITGSGWKEYQKSKTVHGIP 132
Query: 102 LPEGYELPE--PIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKMEEIALKVNEILK 157
+ + E + PI K+++ HD I A KI+G L + ++E+ A+ + +
Sbjct: 133 IGDVVESQQITPIFTPSTKAEQGEHDENITKEQADKIVGKELCD--RIEKFAIDFSTKAR 190
Query: 158 DYLAKRGIILVDFKLEFGKNKNGEIILADEISPDTCRFWDA------ETKKSLDKDVFR- 210
DY A +GII+ D K EFG + + +++ + ++PD+ RFW+A +++ S DK R
Sbjct: 191 DYAATKGIIIADTKFEFGLDGDNIVLVDEVLTPDSSRFWNAAKYEVGKSQDSYDKQFLRD 250
Query: 211 ---------FDKGDLIE--------AYEELYRRITGE 230
D DL E Y E Y ++TG+
Sbjct: 251 WLTSNGVAGKDGVDLPEDIVTETKSKYVEAYEKLTGD 287
>pir||S55291 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC
6.3.2.6) (clone CipA300) - yeast (Candida maltosa)
Length = 291
Score = 74.9 bits (181), Expect = 8e-13
Identities = 65/236 (27%), Positives = 111/236 (46%), Gaps = 28/236 (11%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLL--EEHG 60
+ +GK + + +DD+ + D +A+D + KG + ++S +F L E H
Sbjct: 13 IAKGKVRDIYQVDDNTLLFVATDRISAYDVIMSKGIPNKGKILTKLSEFWFDFLPIENHL 72
Query: 61 IKTHFI----------GVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKR---------LP 101
IK L+V KL + PLEV+VR + GS K +P
Sbjct: 73 IKGDIFQKYPQLEPYRNQLEGRSLLVRKLKLIPLEVIVRGYITGSGWKEYQKSKTVHGIP 132
Query: 102 LPEGYELPE--PIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKMEEIALKVNEILK 157
+ + E + PI K+++ HD I A KI+G L + ++E+IA+ + +
Sbjct: 133 IGDVVESQQITPIFTPSTKAEQGEHDENITKEQADKIVGKELCD--RIEKIAIDLYTKAR 190
Query: 158 DYLAKRGIILVDFKLEFGKNKNGEIILADEISPDTCRFWDAETKKSLDKDVFRFDK 213
DY A +GII+ D K EFG + + +++ + + PD+ FW+A K + K +DK
Sbjct: 191 DYAATKGIIIADTKFEFGLDGDNIVLVDEVLPPDSSTFWNA-AKYEVGKSQDSYDK 245
>pir||S55292 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC
6.3.2.6) (clone CipA400) - yeast (Candida maltosa)
Length = 291
Score = 74.5 bits (180), Expect = 1e-12
Identities = 65/236 (27%), Positives = 112/236 (46%), Gaps = 28/236 (11%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLL--EEHG 60
+ +GK + + +DD+ + D +A+D + KG + ++S +F L E H
Sbjct: 13 IAKGKVRDIYQVDDNTLLFVATDRISAYDVIMSNGIPNKGKILTKLSEFWFDFLPIENHL 72
Query: 61 IKTHFI----------GVAGDNKLIVEKLDMYPLEVVVRNVVAGSLKKR---------LP 101
IK L+V KL + PLEV+VR + GS K +P
Sbjct: 73 IKGDIFQKYPQLEPYRNQLEGRSLLVRKLKLIPLEVIVRGYITGSGWKEYQKSKTVHGIP 132
Query: 102 LPEGYELPE--PIVELYYKSDE-LHDPMINYYHA-KILGITLEEIKKMEEIALKVNEILK 157
+ + E + PI K+++ H I A KI+G L + ++E+IA+ + +
Sbjct: 133 IGDVVESQQITPIFTPTTKAEQGEHAENITKEQADKIVGKELCD--RIEKIAIDLYTKAR 190
Query: 158 DYLAKRGIILVDFKLEFGKNKNGEIILADEISPDTCRFWDAETKKSLDKDVFRFDK 213
DY A +GII+ D K EFG + + +++ + ++PD+ RFW+A K + K +DK
Sbjct: 191 DYAATKGIIIADTKFEFGLDGDNIVLVDEVLTPDSSRFWNA-AKYEVGKSQDSYDK 245
>sp|Q59566|PUR7_MYCTU PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR
SYNTHETASE) >gi|7437950|pir||G70708 probable purC
protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1550658|emb|CAB02370.1| (Z80226) purC [Mycobacterium
tuberculosis]
Length = 297
Score = 74.1 bits (179), Expect = 1e-12
Identities = 67/242 (27%), Positives = 109/242 (44%), Gaps = 42/242 (17%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
V GK +++ +DD+ ++ D +A+D V + KG + +SA FF L++
Sbjct: 11 VASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFFFGLVDA---P 67
Query: 63 THFIGVAGDNK---------LIVEKLDMYPLEVVVRNVVAGSLKKRLPLPE---GYELPE 110
H G D + L+V +L+M P+E V R + GS G LP
Sbjct: 68 NHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQATGKVCGIALPP 127
Query: 111 PIVELYYKSDELHDPMINYYHAKILG-----ITLEEIKKMEEIALKVNEI---------- 155
+VE + P+ LG I+ + + +M AL+ N++
Sbjct: 128 GLVE----ASRFATPLFTPATKAALGDHDENISFDRVVEMVG-ALRANQLRDRTLQTYVQ 182
Query: 156 LKDYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAE------TKKSLDKDV 208
D+ RGII+ D K EFG +++G ++LADEI +PD+ R+W A+ + S DK
Sbjct: 183 AADHALTRGIIIADTKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDKQF 242
Query: 209 FR 210
R
Sbjct: 243 VR 244
>gb|AAB41456.1| (U34957) phosphoribosylaminoimidazolesuccinocarboxamide synthase
[Mycobacterium tuberculosis]
Length = 297
Score = 73.0 bits (176), Expect = 3e-12
Identities = 65/238 (27%), Positives = 106/238 (44%), Gaps = 34/238 (14%)
Query: 3 VYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEEHGIK 62
V GK +++ +DD+ ++ D +A+D V + KG + +SA FF L++
Sbjct: 11 VASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFFFGLVDA---P 67
Query: 63 THFIGVAGDNK---------LIVEKLDMYPLEVVVRNVVAGSLKKRLPLPE---GYELPE 110
H G D + L+V +L+M P+E V R + GS G LP
Sbjct: 68 NHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQATGKVCGIRLPP 127
Query: 111 PIVELYYKSDEL-----------HDPMINYYHAKILGITLEEIKKMEEIALKVNEILKDY 159
+VE + L HD I++ + L ++ + L+ D+
Sbjct: 128 GLVEASRFATPLFTPATKAALGDHDENISFDRVVEMVGPLRA-NQLRDRTLQTYVQAADH 186
Query: 160 LAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAE------TKKSLDKDVFR 210
RGII+ D K EFG +++G ++LADEI +PD+ R+W A+ + S DK R
Sbjct: 187 ALTRGIIIADTKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDKQFVR 244
>emb|CAB56351.1| (AL118514) phosphoribosylaminoimidazole-succinocarboxamide synthase
(EC 6.3.2.6) [Streptomyces coelicolor A3(2)]
Length = 299
Score = 69.9 bits (168), Expect = 3e-11
Identities = 64/223 (28%), Positives = 105/223 (46%), Gaps = 27/223 (12%)
Query: 1 MEVYEGKAKKMIPMDDDKFIMEFKDDATAFDGVKKAKFKGKGWLNAQISAKFFKLLEE-- 58
+ ++ GK +++ + +M D +A+D V + KG + Q+S +F L +
Sbjct: 17 VHLHTGKVRELYRNEAGDLVMVASDRISAYDWVLPTEIPDKGRVLTQLSLWWFDQLADLA 76
Query: 59 --HGIKTHFI-GVAGD---NKLIVEKLDMYPLEVVVRNVVAGSLKKR---------LPLP 103
H + T G D L+ + L M P+E V R + GS L LP
Sbjct: 77 PNHVLSTELPPGAPADWEGRALVCKSLRMVPVECVARGYLTGSGLAEYDETRTVCGLALP 136
Query: 104 EGY----ELPEPIVELYYKSDE-LHDPMINYYH-AKILGITLEEIKKMEEIALKVNEILK 157
EG ELP PI K++ HD ++Y A+ +G + + + L V +
Sbjct: 137 EGLVDGSELPAPIFTPATKAEVGEHDENVSYEEVARQVGA--DTAAALRQATLAVYSRAR 194
Query: 158 DYLAKRGIILVDFKLEFGKNKNGEIILADEI-SPDTCRFWDAE 199
D +RGI+L D K EFG + + +++LADE+ +PD+ RFW A+
Sbjct: 195 DIARERGIVLADTKFEFGFDGD-DLVLADEVLTPDSSRFWPAD 236
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.142 0.407
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92352308
Number of Sequences: 2977
Number of extensions: 4047232
Number of successful extensions: 10872
Number of sequences better than 1.0e-10: 47
Number of HSP's better than 0.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 10753
Number of HSP's gapped (non-prelim): 48
length of query: 234
length of database: 189,106,746
effective HSP length: 54
effective length of query: 180
effective length of database: 156,788,448
effective search space: 28221920640
effective search space used: 28221920640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 164 (68.3 bits)