BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB2411 (top6A) DE:DNA topoisomerase VI, subunit A (top6A)
         (382 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||F75179 DNA topoisomerase VI, chain A (top6a) PAB2411 - Pyro...   783  0.0
sp|O59209|TP6A_PYRHO TYPE II DNA TOPOISOMERASE VI SUBUNIT A           768  0.0
pir||C71034 probable typeII DNA topoisomerase subunit A - Pyroco...   608  e-173
sp|Q9YE67|TP6A_AERPE TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|...   266  2e-70
sp|O05208|TP6A_SULSH TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|...   253  2e-66
gb|AAK41243.1| DNA topoisomerase VI subunit A (top6A) [Sulfolobu...   252  6e-66
sp|O27089|TP6A_METTH TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|...   234  2e-60
sp|Q57815|TP6A_METJA TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|...   230  2e-59
gb|AAG19326.1| (AE005027) DNA topoisomerase VI subunit A; Top6A ...   226  3e-58
gi|11498545 DNA topoisomerase VI, subunit A (top6A) [Archaeoglob...   210  3e-53
pdb|1D3Y|B Chain B, Structure Of The Dna Topoisomerase Vi A Subu...   201  8e-51
pir||T48303 meiosis specific-like protein - Arabidopsis thaliana...   173  4e-42
emb|CAB81544.1| (AJ251989) putative topoisomerase VIA [Arabidops...   123  3e-27
emb|CAB99470.1| (AL135939) dJ481F12.2.1 (SPO11, meiotic protein ...   121  2e-26
gi|6912680 SPO11, meiotic protein covalently bound to DSB (S. ce...   120  2e-26
gi|6755624 sporulation protein, meiosis-specific, SPO11 homolog ...   120  4e-26
emb|CAB99469.1| (AL135939) dJ481F12.2.2 (SPO11, meiotic protein ...   114  2e-24
dbj|BAB01408.1| (AP000375) DNA topoisomerase VI, subunit A [Arab...   111  2e-23
sp|Q9WTK8|SP11_MOUSE SPO11 PROTEIN HOMOLOG >gi|5453472|gb|AAD435...   110  2e-23
gb|AAD43589.1|AF163054_1 (AF163054) meiotic DNA transesterase/to...   107  2e-22
gb|AAD49561.1|AF126400_1 (AF126400) SPO11 protein [Mus musculus]...   103  3e-21
emb|CAB81545.1| (AJ251990) putative topoisomerase VIA [Arabidops...    88  2e-16
gb|AAC61735.1| (AF085276) MEI-W68 [Drosophila melanogaster] >gi|...    75  1e-12

>pir||F75179 DNA topoisomerase VI, chain A (top6a) PAB2411 - Pyrococcus abyssi
           (strain Orsay) >gi|5458027|emb|CAB49517.1| (AJ248284)
           DNA topoisomerase VI, subunit A (top6A) [Pyrococcus
           abyssi]
           Length = 382
           
 Score =  783 bits (2001), Expect = 0.0
 Identities = 382/382 (100%), Positives = 382/382 (100%)

Query: 1   MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARL 60
           MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARL
Sbjct: 1   MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARL 60

Query: 61  IKLGDKLSRRYFLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTREN 120
           IKLGDKLSRRYFLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTREN
Sbjct: 61  IKLGDKLSRRYFLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTREN 120

Query: 121 TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWA 180
           TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWA
Sbjct: 121 TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWA 180

Query: 181 VPGTVEHIQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHR 240
           VPGTVEHIQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHR
Sbjct: 181 VPGTVEHIQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHR 240

Query: 241 LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNL 300
           LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNL
Sbjct: 241 LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNL 300

Query: 301 EHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALAN 360
           EHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALAN
Sbjct: 301 EHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALAN 360

Query: 361 KSLEFVAKEYLPEKIREGKLLP 382
           KSLEFVAKEYLPEKIREGKLLP
Sbjct: 361 KSLEFVAKEYLPEKIREGKLLP 382


>sp|O59209|TP6A_PYRHO TYPE II DNA TOPOISOMERASE VI SUBUNIT A
           Length = 382
           
 Score =  768 bits (1961), Expect = 0.0
 Identities = 371/382 (97%), Positives = 380/382 (99%)

Query: 1   MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARL 60
           MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEE KSGKNPYFDVPTRGLNNVYFDEE+RL
Sbjct: 1   MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEEAKSGKNPYFDVPTRGLNNVYFDEESRL 60

Query: 61  IKLGDKLSRRYFLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTREN 120
           I+LGD+LSRRYFLNVAHARKF QTLILMAYIKRLVSEGKHASLREAYYANKHT+PGTREN
Sbjct: 61  IRLGDRLSRRYFLNVAHARKFMQTLILMAYIKRLVSEGKHASLREAYYANKHTVPGTREN 120

Query: 121 TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWA 180
           TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWA
Sbjct: 121 TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWA 180

Query: 181 VPGTVEHIQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHR 240
           VPGTVEHIQFPE+NVDYVLVVETAAMADRLIEEKYPK+ENCLIVATQGQASRGVRRLIHR
Sbjct: 181 VPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRENCLIVATQGQASRGVRRLIHR 240

Query: 241 LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNL 300
           LHYEEGLPIIVFTDGDPYGWYIYSTIK+GSINLAYLSEKLATPDAKFVGMTMDDIKEYNL
Sbjct: 241 LHYEEGLPIIVFTDGDPYGWYIYSTIKRGSINLAYLSEKLATPDAKFVGMTMDDIKEYNL 300

Query: 301 EHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALAN 360
           E+VTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQ+KEWQRQLKLALKWGVRIEQQALAN
Sbjct: 301 ENVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQDKEWQRQLKLALKWGVRIEQQALAN 360

Query: 361 KSLEFVAKEYLPEKIREGKLLP 382
           KSLEFVAKEYLPEKIREGKLLP
Sbjct: 361 KSLEFVAKEYLPEKIREGKLLP 382


>pir||C71034 probable typeII DNA topoisomerase subunit A - Pyrococcus horikoshii
           >gi|3257992|dbj|BAA30675.1| (AP000006) 301aa long
           hypothetical typeII DNA topoisomerase subunit A
           [Pyrococcus horikoshii]
           Length = 301
           
 Score =  608 bits (1552), Expect = e-173
 Identities = 294/300 (98%), Positives = 300/300 (100%)

Query: 83  QTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERMLGVL 142
           QTLILMAYIKRLVSEGKHASLREAYYANKHT+PGTRENTFEDQSESDPIIEDLERMLGVL
Sbjct: 2   QTLILMAYIKRLVSEGKHASLREAYYANKHTVPGTRENTFEDQSESDPIIEDLERMLGVL 61

Query: 143 REEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYVLVVE 202
           REEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPE+NVDYVLVVE
Sbjct: 62  REEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEINVDYVLVVE 121

Query: 203 TAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYI 262
           TAAMADRLIEEKYPK+ENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYI
Sbjct: 122 TAAMADRLIEEKYPKRENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYI 181

Query: 263 YSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGGPTGDY 322
           YSTIK+GSINLAYLSEKLATPDAKFVGMTMDDIKEYNLE+VTEKLKGIPPDKKGGPTGDY
Sbjct: 182 YSTIKRGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLENVTEKLKGIPPDKKGGPTGDY 241

Query: 323 KRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP 382
           KRLIEELNYPWFQ+KEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP
Sbjct: 242 KRLIEELNYPWFQDKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP 301


>sp|Q9YE67|TP6A_AERPE TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|7446569|pir||G72659
           probable type II DNA topoisomerase VI subunit a APE0703
           - Aeropyrum pernix (strain K1)
           >gi|5104364|dbj|BAA79679.1| (AP000060) 385aa long
           hypothetical type II DNA topoisomerase VI subunit a
           [Aeropyrum pernix]
           Length = 385
           
 Score =  266 bits (674), Expect = 2e-70
 Identities = 145/364 (39%), Positives = 218/364 (59%), Gaps = 20/364 (5%)

Query: 29  KILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVAHARKFTQTLILM 88
           +++ +V  G+ P  ++P R L+N  FD E  ++ +G++   R FLNV  +R+F QTL++ 
Sbjct: 24  RLISDVIKGRPPKLEIPKRTLSNTIFDPERGILVIGEEKLEREFLNVGESRRFMQTLLMA 83

Query: 89  AYIKRLVSEGKHASLREAYYANKHTIP-------GTRENTFEDQSESDPIIEDLERMLGV 141
           + I + + E ++ ++R+ YY  KHTI           ENT+++Q ESD +I+D+E   G+
Sbjct: 84  SIIYQSLIENEYPTIRDLYYKGKHTIVYRDYSGRKREENTWDEQKESDSVIQDIEVYTGL 143

Query: 142 LREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYVLVV 201
            RE+M I +  +G + G++ I+ G D  + SKLG G +A+  T + I+F +V+ ++VLVV
Sbjct: 144 FREDMLILSKEKGKVVGNMRIRSGGDVIDLSKLGHGAYAIEPTPDLIEFLDVDAEFVLVV 203

Query: 202 ETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWY 261
           E  A+  +L    + KK   L+V   GQ  R  RR + RLH E  LP+ + TD DPYGWY
Sbjct: 204 EKDAVFQQLHRAGFWKKYKALLVTGSGQPDRATRRFVRRLHEELKLPVYIITDSDPYGWY 263

Query: 262 IYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDI------KEYNLEHVTEKLKGIPPDKK 315
           IYS  K GSI L+Y SE+LATP AKF+G+ M DI      K Y  E   +K      DK 
Sbjct: 264 IYSVYKVGSITLSYESERLATPKAKFLGVQMTDIFGYRGKKPYLSEAERKKFMIKATDK- 322

Query: 316 GGPTGDYKRLIEELNYPWF-QNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEK 374
                D KR  E LNY W  +N+ W  +++L LK  V++E +A+A+K L+F A +Y+PEK
Sbjct: 323 -----DIKRAKELLNYSWIGKNRRWNVEIRLFLKHLVKLEIEAIASKGLKFFAYQYIPEK 377

Query: 375 IREG 378
           I  G
Sbjct: 378 IETG 381


>sp|O05208|TP6A_SULSH TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|1926404|emb|CAA71605.1|
           (Y10582) type II DNA topoisomerase subunit A [Sulfolobus
           shibatae]
           Length = 389
           
 Score =  253 bits (640), Expect = 2e-66
 Identities = 139/374 (37%), Positives = 223/374 (59%), Gaps = 21/374 (5%)

Query: 17  QKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVA 76
           +K    L D    ++E++K G+    ++P R L+N  +DE+ +L+ LG+K  RR FL++ 
Sbjct: 15  RKAANILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLRRNFLDLN 74

Query: 77  HARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHT-----IPGTR----ENTFEDQSE 127
            A++F QT+++ + I   +   ++ ++R+ YY  KH+     I G +    ENT+++Q E
Sbjct: 75  EAKRFMQTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIEGNKIVSEENTWDEQKE 134

Query: 128 SDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEH 187
           SD +I D+E    +LREEM I +  +G + G++ I+ G D  + SK G G +A+  T + 
Sbjct: 135 SDSVIVDIEVFTSLLREEMLILSKEKGKVVGNLRIRSGNDVIDLSKTGHGAYAIEPTPDL 194

Query: 188 IQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGL 247
           I F +V+ ++VLVVE  A+  +L    + K+   +++ + GQ  R  RR + RL+ E  L
Sbjct: 195 IDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRATRRFVRRLNEELKL 254

Query: 248 PIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDI------KEYNLE 301
           P+ + TD DPYGWYI+S  + GSI+L+Y SE+LATPDAKF+G++M DI      K Y  E
Sbjct: 255 PVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMGDIFGNSRKKPYLSE 314

Query: 302 HVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANK 361
              E+   I   K      D KR  E  NY WF+ K WQ ++   L+   ++E +A+A+K
Sbjct: 315 --AERKNYIIKAK----DADIKRAEEIKNYEWFKTKAWQEEINTFLQRKAKLEIEAMASK 368

Query: 362 SLEFVAKEYLPEKI 375
            L+F+A +Y+PEKI
Sbjct: 369 GLKFLAFQYIPEKI 382


>gb|AAK41243.1| DNA topoisomerase VI subunit A (top6A) [Sulfolobus solfataricus]
           Length = 389
           
 Score =  252 bits (636), Expect = 6e-66
 Identities = 137/374 (36%), Positives = 223/374 (58%), Gaps = 21/374 (5%)

Query: 17  QKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVA 76
           +K    L D    ++E++K G+    ++P R L+N  +DE+ +L+ LG+K  +R FL++ 
Sbjct: 15  RKAASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMN 74

Query: 77  HARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHT-----IPGTR----ENTFEDQSE 127
            A++F QT+++ + I   +   ++ ++R+ YY  KH+     I G +    ENT+++Q E
Sbjct: 75  EAKRFMQTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKE 134

Query: 128 SDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEH 187
           SD +I D+E    +LREEM I +  +G + G++ I+ G D  + SK G G +A+  T + 
Sbjct: 135 SDSVIVDIEVFTSLLREEMLILSKEKGKVVGNLRIRSGNDTIDLSKTGHGAYAIEPTPDL 194

Query: 188 IQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGL 247
           I F +V+ ++VLVVE  A+  +L    + K+   +++ + GQ  R  RR + RL+ E  L
Sbjct: 195 IDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRATRRFVRRLNEELKL 254

Query: 248 PIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDI------KEYNLE 301
           P+ + TD DPYGWYI+S  + GSI+L+Y SE+LATPDAKF+G++M DI      K Y  E
Sbjct: 255 PVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMSDIFGNSRKKPYLSE 314

Query: 302 HVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANK 361
              E+   I   K+     D KR  E  NY WF+ K W+ ++   L    ++E +A+A+K
Sbjct: 315 --AERKNYIIKAKE----ADIKRAEEIKNYEWFKTKAWEEEINTFLHRKAKLEIEAMASK 368

Query: 362 SLEFVAKEYLPEKI 375
            L+F+A +Y+PEKI
Sbjct: 369 GLKFLAFQYIPEKI 382


>sp|O27089|TP6A_METTH TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|7446566|pir||D69001
           conserved hypothetical protein MTH1008 -
           Methanobacterium thermoautotrophicum (strain Delta H)
           >gi|2622109|gb|AAB85504.1| (AE000873) conserved protein
           [Methanobacterium thermoautotrophicum]
           Length = 353
           
 Score =  234 bits (590), Expect = 2e-60
 Identities = 135/357 (37%), Positives = 207/357 (57%), Gaps = 18/357 (5%)

Query: 20  LKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVAHAR 79
           + KL+ L   IL++V  G+ P   VP+RG +N+ +DE+ R   LGD+   R   NV   +
Sbjct: 8   INKLKSLGDVILDDVTQGRIPRIKVPSRGTSNIIYDEDKRHYVLGDRYGTRSMGNVKQIK 67

Query: 80  KFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERML 139
           K  Q L    + K LV+  K A+LRE YY ++       E  F DQ ES+ + EDLE  L
Sbjct: 68  KIGQMLYTANFCKDLVAREKTATLRELYYISEGW-----EVDFADQQESNIVGEDLEVTL 122

Query: 140 GVLREEMHITADRRGY-IYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYV 198
           G+ REE+ +  +  G  +YG + +++G+ E +A + G  G+ +  T++ ++F + +V+ V
Sbjct: 123 GMTREELGLMPEEDGASVYGALTVREGDIEIDALRSGKSGYNISPTIDEVEFVDHDVERV 182

Query: 199 LVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPY 258
           + VET  M  RL++EK  KK + LIV  +GQA+R  RR I R++ E  LP+ +  DGDP+
Sbjct: 183 IAVETMGMFHRLVQEKAYKKFDALIVGLKGQAARATRRFIKRVNEELNLPVYICNDGDPW 242

Query: 259 GWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGGP 318
           G++I   I  GS  LA+++ +LATPDAKF+G+T  DI  Y+L   T+ LK +        
Sbjct: 243 GFHIAMVIISGSAKLAHVNHQLATPDAKFLGVTASDIINYDLP--TDPLKDV-------- 292

Query: 319 TGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKI 375
             D  RL E L  P ++   W+ ++K  L  G + EQQ+ +   LE+V   YLPEK+
Sbjct: 293 --DVVRLKELLQDPRYRGDFWKTEIKKMLTIGKKAEQQSFSKYGLEYVVDTYLPEKL 347


>sp|Q57815|TP6A_METJA TYPE II DNA TOPOISOMERASE VI SUBUNIT A >gi|2128280|pir||A64346
           hypothetical protein MJ0369 - Methanococcus jannaschii
           >gi|1591076|gb|AAB98358.1| (U67490) DNA topoisomerase
           VI, subunit A (top6A) [Methanococcus jannaschii]
           Length = 369
           
 Score =  230 bits (580), Expect = 2e-59
 Identities = 143/372 (38%), Positives = 212/372 (56%), Gaps = 23/372 (6%)

Query: 13  SYDPQKVLK-KLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRY 71
           S  P+++ K K+ +LA K+ E++  GK P   +P R L+N  FD+E     L  K   R 
Sbjct: 8   SKKPREIAKQKIIELAKKMYEDLMKGKRPKITMPIRSLSNAMFDKEKGSFTLVGKEKART 67

Query: 72  FLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPI 131
            L V  A+ F QT  ++ + K+L+     ++LREAYY +K+      E  F+DQ  S+ +
Sbjct: 68  -LTVNQAKIFAQTTKMLEFAKQLLETDDFSTLREAYYVSKNW----GEARFDDQQASNNV 122

Query: 132 IEDLERMLGVLREEMHITADRRGY-IYGDIVI----KDGEDEFNASKLGTGGWAVPGTVE 186
           IEDLE  LGVLRE +    +  G  + G + I     +GE   + +KLGTG + +P  V 
Sbjct: 123 IEDLEAALGVLREHLGFIPEEDGSSVVGPLKIIEETPEGELVVDCTKLGTGAYNIPNDVT 182

Query: 187 HIQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEG 246
            +   E + D++L +ET+ M  RL  E++  K NC++V+ +G  +R  RR I RLH E  
Sbjct: 183 KLNL-ETDADFILAIETSGMFARLNAERFWDKHNCILVSLKGVPARATRRFIKRLHEEHD 241

Query: 247 LPIIVFTDGDPYGWY-IYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTE 305
           LP++VFTDGDPYG+  IY T+K GS    +L++KL+ P A+ +G+T  DI +Y+L     
Sbjct: 242 LPVLVFTDGDPYGYLNIYRTLKVGSGKAIHLADKLSIPAARLIGVTPQDIIDYDLPTHPL 301

Query: 306 KLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEF 365
           K + I   K G    D+ R     ++P     EWQ+ LK  L  GVR EQQ+LA   L++
Sbjct: 302 KEQDIKRIKDGLKNDDFVR-----SFP-----EWQKALKQMLDMGVRAEQQSLAKYGLKY 351

Query: 366 VAKEYLPEKIRE 377
           V   YLPEKI++
Sbjct: 352 VVNTYLPEKIKD 363


>gb|AAG19326.1| (AE005027) DNA topoisomerase VI subunit A; Top6A [Halobacterium sp.
           NRC-1]
           Length = 366
           
 Score =  226 bits (570), Expect = 3e-58
 Identities = 134/374 (35%), Positives = 207/374 (54%), Gaps = 20/374 (5%)

Query: 10  EKFSYDPQKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSR 69
           E  + D  +   +L  +A +  ++   G  P   +PTR  +N+ +DE+A +   GD  S 
Sbjct: 3   ETHTSDETEARDQLLAIAEQFYDQFADGDIPRMSLPTRSKSNIEYDEDADVWVYGDSQST 62

Query: 70  RYFLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESD 129
           R   +V  ARK  +++  + ++ + + EG+ ++LRE YY ++       E  F DQSESD
Sbjct: 63  RSANSVRGARKLLKSVYTVDFLAQQLDEGRSSTLRELYYLSESW--DEAEAQFNDQSESD 120

Query: 130 PIIEDLERMLGVLREEMHITADRRGY-IYGDIVIKD----GEDEFNASK-LGTGGWAVPG 183
            ++EDLE + GV RE+ H+  +  G  + G + +++    G+ E +  + +G GG+ +P 
Sbjct: 121 KLVEDLEIVSGVKREDFHMRPEESGAKVMGPLRLREQTRRGDREIHCQEDVGQGGYQIPN 180

Query: 184 TVEHIQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHY 243
             + I F + + D+VL VET  M DRL+E  +    N ++V   GQ +R  RRL  RLH 
Sbjct: 181 NPDTIDFLDTDADFVLCVETGGMRDRLVENGFDDDYNAIVVHLGGQPARATRRLTKRLHD 240

Query: 244 EEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHV 303
           E  LP+ VFTDGDP+ + IY ++  GSI  A+LSE LATP A+F+G+   DI +Y+L   
Sbjct: 241 ELDLPVTVFTDGDPWSYRIYGSVAYGSIKSAHLSEYLATPQAQFIGIRPQDIVDYDLP-- 298

Query: 304 TEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSL 363
           T+ L             D   L  EL  P FQ+  W  Q+ L L    + EQQALA++ L
Sbjct: 299 TDPLS----------DSDVNALESELEDPRFQSDFWTEQIGLQLDIDKKAEQQALASRGL 348

Query: 364 EFVAKEYLPEKIRE 377
           +FV   YLPE++ E
Sbjct: 349 DFVTDTYLPERLAE 362


>gi|11498545 DNA topoisomerase VI, subunit A (top6A) [Archaeoglobus fulgidus]
           >gi|3122956|sp|O29322|TP6A_ARCFU TYPE II DNA
           TOPOISOMERASE VI SUBUNIT A >gi|7446567|pir||D69367 DNA
           topoisomerase VI, subunit A (top6A) homolog -
           Archaeoglobus fulgidus >gi|2649657|gb|AAB90299.1|
           (AE001039) DNA topoisomerase VI, subunit A (top6A)
           [Archaeoglobus fulgidus]
           Length = 360
           
 Score =  210 bits (528), Expect = 3e-53
 Identities = 125/367 (34%), Positives = 207/367 (56%), Gaps = 22/367 (5%)

Query: 17  QKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVA 76
           ++ L+ L  +   I +++K+G+ P   + TR   N+ F+EE+ +   GD+ S R    V 
Sbjct: 6   RRCLRALIGIVQNIYDQMKAGQVPELHIATRTKYNIEFNEESEVWVYGDRKSVRSAKTVK 65

Query: 77  HARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLE 136
            A +  +   ++ ++K  ++  K ++LRE YY ++    G     FE+Q ESD ++EDLE
Sbjct: 66  GAYRILKMTYVIGFLKEQLNLNKSSTLRELYYISE----GWGAAKFEEQPESDRLVEDLE 121

Query: 137 RMLGVLREEMHITADRRGY-IYGDIVIKD----GEDEFNASK-LGTGGWAVPGTVEHIQF 190
            +    RE  HI  +  G  + G + +++    G  E +    +G GG+ +P  V+ I+F
Sbjct: 122 ILTNFQREHFHIRPEEDGATVIGPLRVREETRRGVREIHCQDDVGEGGYQIPVNVDKIEF 181

Query: 191 PEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPII 250
            + +  +V+ +ET  M DRL+E  + +K + +IV  +GQ +R  RRL+ RL+ E  LP++
Sbjct: 182 VDHDAKFVIAIETGGMRDRLVENGFDEKYDAIIVHLKGQPARSTRRLLRRLNTELNLPVV 241

Query: 251 VFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGI 310
           VFTDGDP+ + I++++  GSI  A+LSE LATP A+FVG+   DI +Y+L          
Sbjct: 242 VFTDGDPWSYRIFASVAYGSIKSAHLSEYLATPAAQFVGIRPTDIVKYDL---------- 291

Query: 311 PPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEY 370
           P DK      D K L   L  P F ++ W++++ L L+   + EQQALA   L++V   Y
Sbjct: 292 PADKL--TEEDIKALNAILTDPRFDSEFWKKEVNLQLEINKKSEQQALAKYGLDYVTDVY 349

Query: 371 LPEKIRE 377
           LPE++ E
Sbjct: 350 LPERLSE 356


>pdb|1D3Y|B Chain B, Structure Of The Dna Topoisomerase Vi A Subunit
           >gi|6573667|pdb|1D3Y|A Chain A, Structure Of The Dna
           Topoisomerase Vi A Subunit
           Length = 301
           
 Score =  201 bits (507), Expect = 8e-51
 Identities = 121/309 (39%), Positives = 179/309 (57%), Gaps = 21/309 (6%)

Query: 75  VAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIED 134
           V  A+ F QT  ++ + K+L+     ++LREAYY +K+      E  F+DQ  S+ +IED
Sbjct: 2   VNQAKIFAQTTKMLEFAKQLLETDDFSTLREAYYVSKNW----GEARFDDQQASNNVIED 57

Query: 135 LERMLGVLREEMHITADRRGY-IYGDIVI----KDGEDEFNASKLGTGGWAVPGTVEHIQ 189
           LE  LGVLRE +    +  G  + G + I     +GE   + +KLGTG + +P  V  + 
Sbjct: 58  LEAALGVLREHLGFIPEEDGSSVVGPLKIIEETPEGELVVDCTKLGTGAYNIPNDVTKLN 117

Query: 190 FPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPI 249
             E + D++L +ET+ M  RL  E++  K NC++V+ +G  +R  RR I RLH E  LP+
Sbjct: 118 L-ETDADFILAIETSGMFARLNAERFWDKHNCILVSLKGVPARATRRFIKRLHEEHDLPV 176

Query: 250 IVFTDGDPYGWY-IYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLK 308
           +VFTDGDPYG+  IY T+K GS    +L++KL+ P A+ +G+T  DI +Y+L     K +
Sbjct: 177 LVFTDGDPYGYLNIYRTLKVGSGKAIHLADKLSIPAARLIGVTPQDIIDYDLPTHPLKEQ 236

Query: 309 GIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAK 368
            I   K G    D+ R     ++P     EWQ+ LK  L  GVR EQQ+LA   L++V  
Sbjct: 237 DIKRIKDGLKNDDFVR-----SFP-----EWQKALKQMLDMGVRAEQQSLAKYGLKYVVN 286

Query: 369 EYLPEKIRE 377
            YLPEKI++
Sbjct: 287 TYLPEKIKD 295


>pir||T48303 meiosis specific-like protein - Arabidopsis thaliana
           >gi|7413557|emb|CAB86036.1| (AL162973) meiosis
           specific-like protein [Arabidopsis thaliana]
           Length = 427
           
 Score =  173 bits (433), Expect = 4e-42
 Identities = 104/359 (28%), Positives = 186/359 (50%), Gaps = 16/359 (4%)

Query: 19  VLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVAHA 78
           V  ++E +  +I   + +G    F VP+R  +N  +  E   I L DK + R F +V+  
Sbjct: 81  VQTEIETVIVQIARSILAGDGFSFSVPSRAASNQLYVPELDRIVLKDKSTLRPFASVSSV 140

Query: 79  RKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERM 138
           RK T T  ++A I +L     H + R+ +Y        T    F+DQ++SD +++D+  M
Sbjct: 141 RKTTITTRILALIHQLCLRNIHVTKRDLFY--------TDVKLFQDQTQSDAVLDDVSCM 192

Query: 139 LGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYV 198
           LG  R  +++ A  +G + G ++  D  D  + +K+G GG A+P  ++ +   + +  ++
Sbjct: 193 LGCTRSSLNVIAAEKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFI 252

Query: 199 LVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPY 258
           L+VE  A   RL E+++  +  C+IV  +GQ     R  + ++  E  LP++   D DPY
Sbjct: 253 LLVEKDAAYMRLAEDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPY 312

Query: 259 GWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGGP 318
           G  I S    GS N++Y S  L TPD K++G+   D+ +Y +         +P  ++   
Sbjct: 313 GLKILSVYGCGSKNMSYDSANLTTPDIKWLGIRPSDLDKYKIPEQCR----LPMTEQDIK 368

Query: 319 TGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIRE 377
           TG  K ++EE      +N  W  +L L +K   + E QAL++   +++++ YLP K+++
Sbjct: 369 TG--KDMLEEDFVK--KNPGWVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQ 423


>emb|CAB81544.1| (AJ251989) putative topoisomerase VIA [Arabidopsis thaliana]
           Length = 362
           
 Score =  123 bits (306), Expect = 3e-27
 Identities = 88/364 (24%), Positives = 168/364 (45%), Gaps = 26/364 (7%)

Query: 19  VLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVA-- 76
           +L++++D    ++ ++  G++P   +      N   + EA  +   DK   +    +   
Sbjct: 13  LLQRIKDFTQSVVVDLAEGRSPKISI--NQFRNYCMNPEADCLCSSDKPKGQEIFTLKKE 70

Query: 77  -HARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDL 135
               +    L ++  +++L+ E +HAS R+ YY +         + F+ QS  D  I D+
Sbjct: 71  PQTYRIDMLLRVLLIVQQLLQENRHASKRDIYYMHP--------SAFKAQSIVDRAIGDI 122

Query: 136 ERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNV 195
             +    R  +++ +   G + G +  ++   +F+        + VP  VE ++      
Sbjct: 123 CILFQCSRYNLNVVSVGNGLVMGWLKFREAGRKFDCLNSLNTAYPVPVLVEEVEDIVSLA 182

Query: 196 DYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDG 255
           +Y+LVVE   +  RL  + + K   C+++  +G      RR +  L  +  LP+    D 
Sbjct: 183 EYILVVEKETVFQRLANDMFCKTNRCIVITGRGYPDVSTRRFLRLLMEKLHLPVHCLVDC 242

Query: 256 DPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKK 315
           DPYG+ I +T + GS+ +AY  E L  PD K++G    D + Y+          +P    
Sbjct: 243 DPYGFEILATYRFGSMQMAYDIESLRAPDMKWLGAFPSDSEVYS----------VPKQCL 292

Query: 316 GGPTGDYKRLIEELNYPWFQNKE---WQRQLKLALKWGVRIEQQALANKSLEFVAKEYLP 372
              T + K+  E +    +  +E   W+ +L+  LK GV+ E +AL+  SL F+++ Y+P
Sbjct: 293 LPLTEEDKKRTEAMLLRCYLKREMPQWRLELETMLKRGVKFEIEALSVHSLSFLSEVYIP 352

Query: 373 EKIR 376
            KIR
Sbjct: 353 SKIR 356


>emb|CAB99470.1| (AL135939) dJ481F12.2.1 (SPO11, meiotic protein covalently bound to
           DSB (S. cerevisiae)-like (a DNA
           transesterase/topoisomerase homolog isoform 1)) [Homo
           sapiens]
           Length = 395
           
 Score =  121 bits (300), Expect = 2e-26
 Identities = 94/379 (24%), Positives = 182/379 (47%), Gaps = 23/379 (6%)

Query: 5   RQKPKEKFSYDPQKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGL-NNVYFDEEARLIKL 63
           R+ P         +VL  +E++   I+  +   + P F +  R    N+ F++   L  +
Sbjct: 32  REPPTGGSRLASSEVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMV 91

Query: 64  GDKLSRRYFLNVAH-ARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTF 122
               +R+   +    A+KF+  L +++ I +LV    +A+ R+ YY        T    F
Sbjct: 92  SHCTTRKIKSDSPKSAQKFSLILKILSMIYKLVQSNTYATKRDIYY--------TDSQLF 143

Query: 123 EDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDI-VIKDGEDEFNASKLGTGGWAV 181
            +Q+  D II D+  ML V R  +HI +  +G I G++  I++   + N +  G    AV
Sbjct: 144 GNQTVVDNIINDISCMLKVSRRSLHILSTSKGLIAGNLRYIEEDGTKVNCT-CGATAVAV 202

Query: 182 PGTVEHIQFPEVNVDYVLVVETAAMADRLIEEKYPKKEN-CLIVATQGQASRGVRRLIHR 240
           P  ++ I+    +  +VL+VE  A   RL+++ +  K + C+++  +G      R L+ +
Sbjct: 203 PSNIQGIRNLVTDAKFVLIVEKDATFQRLLDDNFCNKLSPCIMITGKGVPDLNTRLLVKK 262

Query: 241 LHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNL 300
           L     +P+    D DP+G  I    K GS+++++ +  L  P  +++G+   D+K  N+
Sbjct: 263 LWDTFHVPVFTLVDADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKRLNV 322

Query: 301 EHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKE-WQRQLKLALKWGVRIEQQALA 359
                K   IP  K+     D  +L   L  P+   +  W++++++     ++ E QAL 
Sbjct: 323 ----PKDSLIPLTKR-----DQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALT 373

Query: 360 NKSLEFVAKEYLPEKIREG 378
             S +++++ YLP K++ G
Sbjct: 374 FLSSDYLSRVYLPNKLKFG 392


>gi|6912680 SPO11, meiotic protein covalently bound to DSB (S. cerevisiae)-like
           [Homo sapiens] >gi|11422023|ref|XP_009661.1| SPO11,
           meiotic protein covalently bound to DSB (S.
           cerevisiae)-like [Homo sapiens]
           >gi|7674367|sp|Q9Y5K1|SP11_HUMAN SPO11 PROTEIN HOMOLOG
           >gi|5532654|gb|AAD44812.1|AF149310_1 (AF149310) Spo11
           homolog [Homo sapiens]
           >gi|5815131|gb|AAD52562.1|AF169385_1 (AF169385) SPO11
           [Homo sapiens]
           Length = 396
           
 Score =  120 bits (299), Expect = 2e-26
 Identities = 92/366 (25%), Positives = 179/366 (48%), Gaps = 23/366 (6%)

Query: 18  KVLKKLEDLAWKILEEVKSGKNPYFDVPTRGL-NNVYFDEEARLIKLGDKLSRRYFLNVA 76
           +VL  +E++   I+  +   + P F +  R    N+ F++   L  +    +R+   +  
Sbjct: 46  EVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKSDSP 105

Query: 77  H-ARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDL 135
             A+KF+  L +++ I +LV    +A+ R+ YY        T    F +Q+  D II D+
Sbjct: 106 KSAQKFSLILKILSMIYKLVQSNTYATKRDIYY--------TDSQLFGNQTVVDNIINDI 157

Query: 136 ERMLGVLREEMHITADRRGYIYGDI-VIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVN 194
             ML V R  +HI +  +G I G++  I++   + N +  G    AVP  ++ I+    +
Sbjct: 158 SCMLKVSRRSLHILSTSKGLIAGNLRYIEEDGTKVNCT-CGATAVAVPSNIQGIRNLVTD 216

Query: 195 VDYVLVVETAAMADRLIEEKYPKKEN-CLIVATQGQASRGVRRLIHRLHYEEGLPIIVFT 253
             +VL+VE  A   RL+++ +  K + C+++  +G      R L+ +L     +P+    
Sbjct: 217 AKFVLIVEKDATFQRLLDDNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHVPVFTLV 276

Query: 254 DGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPD 313
           D DP+G  I    K GS+++++ +  L  P  +++G+   D+K  N+     K   IP  
Sbjct: 277 DADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKRLNV----PKDSLIPLT 332

Query: 314 KKGGPTGDYKRLIEELNYPWFQNKE-WQRQLKLALKWGVRIEQQALANKSLEFVAKEYLP 372
           K+     D  +L   L  P+   +  W++++++     ++ E QAL   S +++++ YLP
Sbjct: 333 KR-----DQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLP 387

Query: 373 EKIREG 378
            K++ G
Sbjct: 388 NKLKFG 393


>gi|6755624 sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae)
           [Mus musculus] >gi|5815133|gb|AAD52563.1|AF169386_1
           (AF169386) SPO11 [Mus musculus]
           >gi|9367101|gb|AAF87096.1|AF173848_1 (AF173848) SPO11
           protein [Mus musculus]
           Length = 396
           
 Score =  120 bits (297), Expect = 4e-26
 Identities = 88/365 (24%), Positives = 173/365 (47%), Gaps = 21/365 (5%)

Query: 18  KVLKKLEDLAWKILEEVKSGKNPYFDVPTRGL-NNVYFDEEARLIKLGDKLSRRYFLNVA 76
           +VL  +E++   I++ +   + P F +  R    N+ FD+   L  +    +R+   +  
Sbjct: 46  EVLTAIENIIQDIIKSLARNEVPAFTIDNRSSWENIMFDDSVGLRMIPQCTTRKIRSDSP 105

Query: 77  HA-RKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDL 135
            + +KF   L +++ I +L+    +A+ R+ YY        T    F +Q+  D  I+D+
Sbjct: 106 KSVKKFALILKVLSMIYKLIQSDTYATKRDIYY--------TDSQLFGNQAAVDSAIDDI 157

Query: 136 ERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNV 195
             ML V R  +H+ +  +G I G++   + +             AVP  ++ +Q    + 
Sbjct: 158 SCMLKVPRRSLHVLSTSKGLIAGNLRYMEEDGTRVQCTCSATATAVPTNIQGMQHLITDA 217

Query: 196 DYVLVVETAAMADRLIEEKYPKKEN-CLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTD 254
            ++L+VE  A   RL+++ +  + + C++V  +G      R L+ +L     +P+    D
Sbjct: 218 KFLLIVEKDATFQRLLDDNFCSRMSPCIMVTGKGVPDLNTRLLVKKLWDTFHIPVFTLVD 277

Query: 255 GDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDK 314
            DPYG  I    K GS+++++ +  L  P  +++G+   DI+  N+     K   IP  K
Sbjct: 278 ADPYGIEIMCIYKYGSMSMSFEAHNLTIPTIRWLGLLPSDIQRLNI----PKDSLIPLTK 333

Query: 315 KGGPTGDYKRLIEELNYPWFQNKE-WQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPE 373
                 D  +L   L  P+   +  W+++L++     ++ E QAL   S +++++ YLP 
Sbjct: 334 H-----DQMKLDSILKRPYITYQPLWKKELEMMADSKMKAEIQALTLLSSDYLSRVYLPN 388

Query: 374 KIREG 378
           K+R G
Sbjct: 389 KLRFG 393


>emb|CAB99469.1| (AL135939) dJ481F12.2.2 (SPO11, meiotic protein covalently bound to
           DSB (S.cerevisiae)-like (meiotic DNA
           transesterase/topoisomerase homolog isoform 2 (high
           similarity to mouse variant))) [Homo sapiens]
           Length = 357
           
 Score =  114 bits (283), Expect = 2e-24
 Identities = 89/348 (25%), Positives = 169/348 (47%), Gaps = 26/348 (7%)

Query: 35  KSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVAH-ARKFTQTLILMAYIKR 93
           + G+ P    PT G     F++   L  +    +R+   +    A+KF+  L +++ I +
Sbjct: 29  RGGREP----PTGGSRLASFEDSVGLQMVSHCTTRKIKSDSPKSAQKFSLILKILSMIYK 84

Query: 94  LVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERMLGVLREEMHITADRR 153
           LV    +A+ R+ YY        T    F +Q+  D II D+  ML V R  +HI +  +
Sbjct: 85  LVQSNTYATKRDIYY--------TDSQLFGNQTVVDNIINDISCMLKVSRRSLHILSTSK 136

Query: 154 GYIYGDI-VIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYVLVVETAAMADRLIE 212
           G I G++  I++   + N +  G    AVP  ++ I+    +  +VL+VE  A   RL++
Sbjct: 137 GLIAGNLRYIEEDGTKVNCT-CGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLLD 195

Query: 213 EKYPKKEN-CLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSI 271
           + +  K + C+++  +G      R L+ +L     +P+    D DP+G  I    K GS+
Sbjct: 196 DNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHVPVFTLVDADPHGIEIMCIYKYGSM 255

Query: 272 NLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGGPTGDYKRLIEELNY 331
           ++++ +  L  P  +++G+   D+K  N+     K   IP  K+     D  +L   L  
Sbjct: 256 SMSFEAHHLTVPAIRWLGLLPSDLKRLNV----PKDSLIPLTKR-----DQMKLDSILRR 306

Query: 332 PWFQNKE-WQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREG 378
           P+   +  W++++++     ++ E QAL   S +++++ YLP K++ G
Sbjct: 307 PYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFG 354


>dbj|BAB01408.1| (AP000375) DNA topoisomerase VI, subunit A [Arabidopsis thaliana]
           Length = 357
           
 Score =  111 bits (274), Expect = 2e-23
 Identities = 90/365 (24%), Positives = 167/365 (45%), Gaps = 33/365 (9%)

Query: 19  VLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVAHA 78
           +L++++D    ++ ++  G++P   +      N   + EA  +   DK   +    +   
Sbjct: 13  LLQRIKDFTQSVVVDLAEGRSPKISI--NQFRNYCMNPEADCLCSSDKPKGQEIFTL--- 67

Query: 79  RKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERM 138
           +K  QT  +   +++L+ E +HAS R+ YY +         + F+ QS  D  I D+  +
Sbjct: 68  KKEPQTYRI---VQQLLQENRHASKRDIYYMHP--------SAFKAQSIVDRAIGDICIL 116

Query: 139 LGVLREEMH----ITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVN 194
               R  ++    I       + G +  ++   +F+        + VP  VE ++     
Sbjct: 117 FQCSRYNLNVIHLIILLCCRLVMGWLKFREAGRKFDCLNSLNTAYPVPVLVEEVEDIVSL 176

Query: 195 VDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTD 254
            +Y+LVVE   +  RL  + + K   C+++  +G      RR +  L  +  LP+    D
Sbjct: 177 AEYILVVEKETVFQRLANDMFCKTNRCIVITGRGYPDVSTRRFLRLLMEKLHLPVHCLVD 236

Query: 255 GDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDK 314
            DPYG+ I +T + GS+ +AY  E L  PD K++G    D + Y+          +P   
Sbjct: 237 CDPYGFEILATYRFGSMQMAYDIESLRAPDMKWLGAFPSDSEVYS----------VPKQC 286

Query: 315 KGGPTGDYKRLIEELNYPWFQNKE---WQRQLKLALKWGVRIEQQALANKSLEFVAKEYL 371
               T + K+  E +    +  +E   W+ +L+  LK GV+ E +AL+  SL F+++ Y+
Sbjct: 287 LLPLTEEDKKRTEAMLLRCYLKREMPQWRLELETMLKRGVKFEIEALSVHSLSFLSEVYI 346

Query: 372 PEKIR 376
           P KIR
Sbjct: 347 PSKIR 351


>sp|Q9WTK8|SP11_MOUSE SPO11 PROTEIN HOMOLOG >gi|5453472|gb|AAD43588.1|AF163053_1
           (AF163053) meiotic DNA transesterase/topoisomerase
           homolog variant A [Mus musculus]
           >gi|5453482|gb|AAD43591.1| (AF163052) meiotic DNA
           transesterase/topoisomerase homolog variant A [Mus
           musculus] >gi|5532652|gb|AAD44811.1|AF149309_1
           (AF149309) Spo11 homolog [Mus musculus]
           >gi|9367033|gb|AAF87090.1|AF165313_1 (AF165313) SPO11
           [Mus musculus]
           Length = 358
           
 Score =  110 bits (273), Expect = 2e-23
 Identities = 76/302 (25%), Positives = 145/302 (47%), Gaps = 19/302 (6%)

Query: 79  RKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERM 138
           +KF   L +++ I +L+    +A+ R+ YY        T    F +Q+  D  I+D+  M
Sbjct: 71  KKFALILKVLSMIYKLIQSDTYATKRDIYY--------TDSQLFGNQAAVDSAIDDISCM 122

Query: 139 LGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYV 198
           L V R  +H+ +  +G I G++   + +             AVP  ++ +Q    +  ++
Sbjct: 123 LKVPRRSLHVLSTSKGLIAGNLRYMEEDGTRVQCTCSATATAVPTNIQGMQHLITDAKFL 182

Query: 199 LVVETAAMADRLIEEKYPKKEN-CLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDP 257
           L+VE  A   RL+++ +  + + C++V  +G      R L+ +L     +P+    D DP
Sbjct: 183 LIVEKDATFQRLLDDNFCSRMSPCIMVTGKGVPDLNTRLLVKKLWDTFHIPVFTLVDADP 242

Query: 258 YGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGG 317
           YG  I    K GS+++++ +  L  P  +++G+   DI+  N+     K   IP  K   
Sbjct: 243 YGIEIMCIYKYGSMSMSFEAHNLTIPTIRWLGLLPSDIQRLNI----PKDSLIPLTKH-- 296

Query: 318 PTGDYKRLIEELNYPWFQNKE-WQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIR 376
              D  +L   L  P+   +  W+++L++     ++ E QAL   S +++++ YLP K+R
Sbjct: 297 ---DQMKLDSILKRPYITYQPLWKKELEMMADSKMKAEIQALTLLSSDYLSRVYLPNKLR 353

Query: 377 EG 378
            G
Sbjct: 354 FG 355


>gb|AAD43589.1|AF163054_1 (AF163054) meiotic DNA transesterase/topoisomerase homolog variant
           B [Mus musculus] >gi|5453483|gb|AAD43592.1| (AF163052)
           meiotic DNA transesterase/topoisomerase homolog variant
           B [Mus musculus]
           Length = 354
           
 Score =  107 bits (265), Expect = 2e-22
 Identities = 76/302 (25%), Positives = 145/302 (47%), Gaps = 23/302 (7%)

Query: 79  RKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERM 138
           +KF   L +++ I +L+    +A+ R+ YY        T    F +Q+  D  I+D+  M
Sbjct: 71  KKFALILKVLSMIYKLIQSDTYATKRDIYY--------TDSQLFGNQAAVDSAIDDISCM 122

Query: 139 LGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYV 198
           L V R  +H+ +  +G I G++   + +             AVP  ++ +Q    +  ++
Sbjct: 123 LKVPRRSLHVLSTSKGLIAGNLRYMEEDGTRVQCTCSATATAVPTNIQGMQ----HAKFL 178

Query: 199 LVVETAAMADRLIEEKYPKKEN-CLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDP 257
           L+VE  A   RL+++ +  + + C++V  +G      R L+ +L     +P+    D DP
Sbjct: 179 LIVEKDATFQRLLDDNFCSRMSPCIMVTGKGVPDLNTRLLVKKLWDTFHIPVFTLVDADP 238

Query: 258 YGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGG 317
           YG  I    K GS+++++ +  L  P  +++G+   DI+  N+     K   IP  K   
Sbjct: 239 YGIEIMCIYKYGSMSMSFEAHNLTIPTIRWLGLLPSDIQRLNI----PKDSLIPLTKH-- 292

Query: 318 PTGDYKRLIEELNYPWFQNKE-WQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIR 376
              D  +L   L  P+   +  W+++L++     ++ E QAL   S +++++ YLP K+R
Sbjct: 293 ---DQMKLDSILKRPYITYQPLWKKELEMMADSKMKAEIQALTLLSSDYLSRVYLPNKLR 349

Query: 377 EG 378
            G
Sbjct: 350 FG 351


>gb|AAD49561.1|AF126400_1 (AF126400) SPO11 protein [Mus musculus]
           >gi|9367040|gb|AAF87094.1|AF167439_1 (AF167439) SPO11b
           [Mus musculus]
           Length = 371
           
 Score =  103 bits (255), Expect = 3e-21
 Identities = 76/311 (24%), Positives = 147/311 (46%), Gaps = 24/311 (7%)

Query: 79  RKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPG---------TRENTFEDQSESD 129
           +KF   L +++ I +L+    +A+ R    +N H++           T    F +Q+  D
Sbjct: 71  KKFALILKVLSMIYKLIQSDTYATKR----SNAHSVLTLHLHRDIYYTDSQLFGNQAAVD 126

Query: 130 PIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQ 189
             I+D+  ML V R  +H+ +  +G I G++   + +             AVP  ++ +Q
Sbjct: 127 SAIDDISCMLKVPRRSLHVLSTSKGLIAGNLRYMEEDGTRVQCTCSATATAVPTNIQGMQ 186

Query: 190 FPEVNVDYVLVVETAAMADRLIEEKYPKKEN-CLIVATQGQASRGVRRLIHRLHYEEGLP 248
               +  ++L+VE  A   RL+++ +  + + C++V  +G      R L+ +L     +P
Sbjct: 187 HLITDAKFLLIVEKDATFQRLLDDNFCSRMSPCIMVTGKGVPDLNTRLLVKKLWDTFHIP 246

Query: 249 IIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLK 308
           +    D DPYG  I    K GS+++++ +  L  P  +++G+   DI+  N+     K  
Sbjct: 247 VFTLVDADPYGIEIMCIYKYGSMSMSFEAHNLTIPTIRWLGLLPSDIQRLNI----PKDS 302

Query: 309 GIPPDKKGGPTGDYKRLIEELNYPWFQNKE-WQRQLKLALKWGVRIEQQALANKSLEFVA 367
            IP  K      D  +L   L  P+   +  W+++L++     ++ E QAL   S ++++
Sbjct: 303 LIPLTKH-----DQMKLDSILKRPYITYQPLWKKELEMMADSKMKAEIQALTLLSSDYLS 357

Query: 368 KEYLPEKIREG 378
           + YLP K+R G
Sbjct: 358 RVYLPNKLRFG 368


>emb|CAB81545.1| (AJ251990) putative topoisomerase VIA [Arabidopsis thaliana]
           Length = 383
           
 Score = 87.8 bits (214), Expect = 2e-16
 Identities = 77/325 (23%), Positives = 148/325 (44%), Gaps = 22/325 (6%)

Query: 61  IKLGDKLSRRYFLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTREN 120
           I L    ++    N   A+ F +   +M    +++ + K  + RE +Y      P    +
Sbjct: 77  IFLSTSFTKSSLTNAKTAKAFVRVWKVMEICFQILLQEKRVTQRELFYKLLCDSP----D 132

Query: 121 TFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKD-GEDEFNASKLGTGGW 179
            F  Q E +  ++D+  +L   R  + I A  RG + G + +++ G++  + S  G+ G+
Sbjct: 133 YFSSQIEVNRSVQDVVALLRCSRYSLGIMASSRGLVAGRLFLQEPGKEAVDCSACGSSGF 192

Query: 180 AVPGTVEHIQFPEVNVD--YVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRL 237
           A+ G +  +    +  D  Y+++VE  A+  RL+E++      C+ +  +G      R  
Sbjct: 193 AITGDLNLLDNTIMRTDARYIIIVEKHAIFHRLVEDRVFNHIPCVFITAKGYPDIATRFF 252

Query: 238 IHRLHYE-EGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIK 296
           +HR+      LPI+V  D +P G  I  T K GSI +   + + A  + K++G+  DD+ 
Sbjct: 253 LHRMSTTFPDLPILVLVDWNPAGLAILCTFKFGSIGMGLEAYRYAC-NVKWIGLRGDDL- 310

Query: 297 EYNLEHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQ 356
             NL      +   P D +   +    ++++E          +  +L L ++ G R E +
Sbjct: 311 --NLIPEESLVPLKPKDSQIAKSLLSSKILQE---------NYIEELSLMVQTGKRAEIE 359

Query: 357 ALANKSLEFVAKEYLPEKIREGKLL 381
           AL      ++ K Y+  KI +GK +
Sbjct: 360 ALYCHGYNYLGK-YIATKIVQGKYI 383


>gb|AAC61735.1| (AF085276) MEI-W68 [Drosophila melanogaster]
           >gi|7302468|gb|AAF57553.1| (AE003795) mei-W68 gene
           product [Drosophila melanogaster]
           Length = 331
           
 Score = 75.3 bits (182), Expect = 1e-12
 Identities = 78/363 (21%), Positives = 146/363 (39%), Gaps = 39/363 (10%)

Query: 21  KKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVAHARK 80
           + +E +A ++L  +  G N    VP     NV    E R +   ++ SR           
Sbjct: 6   ENIERIALELLSNLVHG-NATLSVPRNSSGNVI--SEYRRVSYNNRGSRH---------S 53

Query: 81  FTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERMLG 140
           F   + +++ + RL   G   ++R  YY N   +          QS       D+ RML 
Sbjct: 54  FCVLIYMLSRVHRLQVRGGSFTVRGLYYDNPLLV--------RSQSRIAEARLDVCRMLR 105

Query: 141 VLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYVLV 200
                + I A  +G + GD+ +     +   S L  G   +P   E I   E   ++VL+
Sbjct: 106 TSPLSLGILAASKGLVAGDLRLLMTNGDVLDSSLYGGPLTLPTDPEKIDRIETLAEFVLI 165

Query: 201 VETAAMADRLIEEKY--PKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPY 258
           VE  ++ + L+        +   +++  +G      RR++HRL  E  L   +  D DP+
Sbjct: 166 VEKESVFESLLSRNVFGTFERRFILITGKGYPDCCTRRIVHRLTEENQLAAYILVDADPF 225

Query: 259 GWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGGP 318
           G  I    + GS ++++ S+ L TP  +++G+   +I       V               
Sbjct: 226 GVEIMLVYRHGSKSMSFSSQGLTTPALRWIGLHPSEIPALGTGAVAL------------V 273

Query: 319 TGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREG 378
            GD K++ + L        + +  ++  L+    ++ +A     ++F+  +Y+P KI   
Sbjct: 274 AGDNKKINDLL-----ARHDLEPGVRQELRMLQDVQLKAEIESVIDFLTDDYIPNKINRN 328

Query: 379 KLL 381
             L
Sbjct: 329 LFL 331


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.317    0.138    0.403 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 153446881
Number of Sequences: 2977
Number of extensions: 6911377
Number of successful extensions: 15508
Number of sequences better than 1.0e-10: 23
Number of HSP's better than  0.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 15434
Number of HSP's gapped (non-prelim): 23
length of query: 382
length of database: 189,106,746
effective HSP length: 56
effective length of query: 326
effective length of database: 155,591,474
effective search space: 50722820524
effective search space used: 50722820524
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 166 (69.1 bits)