BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2417 (guaA-C) DE:GMP synthase, Cter domain
(308 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||C75125 gmp synthase, cter domain PAB2417 - Pyrococcus abyss... 614 e-175
pir||E71006 probable GMP synthase - Pyrococcus horikoshii >gi|32... 599 e-171
pir||B64441 GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) - ... 406 e-112
gi|11497869 GMP synthase (guaA-1) [Archaeoglobus fulgidus] >gi|7... 379 e-104
pir||H69194 GMP synthetase, subunit B - Methanobacterium thermoa... 377 e-103
pir||G72206 GMP synthase - Thermotoga maritima (strain MSB8) >gi... 362 3e-99
sp|O66601|GUAA_AQUAE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 359 2e-98
gb|AAG20037.1| (AE005084) GMP synthase subunit B; GuaAb [Halobac... 356 1e-97
sp|P49057|GUAA_SYNY3 PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZIN... 342 2e-93
emb|CAC12482.1| (AL445067) probable GMP synthase [Thermoplasma a... 339 3e-92
dbj|BAB04326.1| (AP001509) GMP synthetase [Bacillus halodurans] 338 6e-92
gb|AAC33274.1| (AF051937) GMP synthetase [Lactobacillus rhamnosus] 333 2e-90
sp|P29727|GUAA_BACSU GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 332 3e-90
pir||C72476 probable GMP synthase APE2452 - Aeropyrum pernix (st... 332 3e-90
pir||B42280 GMP synthetase - Bacillus subtilis 328 5e-89
gb|AAA22497.1| (M83691) GMP synthetase [Bacillus subtilis] 328 5e-89
gb|AAD15805.1| (AF058326) GMP synthase [Lactococcus lactis] 328 7e-89
emb|CAB82024.1| (AL161755) GMP synthase [Streptomyces coelicolor... 313 1e-84
sp|P44335|GUAA_HAEIN GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 305 4e-82
pir||T31103 probable GMP synthase (glutamine-hydrolyzing) (EC 6.... 304 9e-82
pir||B81332 GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) Cj... 303 1e-81
pir||D81701 GMP synthase TC0442 [imported] - Chlamydia muridarum... 303 1e-81
sp|P04079|GUAA_ECOLI GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 302 5e-81
sp|Q50729|GUAA_MYCTU GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 301 8e-81
pir||D82282 GMP synthase VC0768 [imported] - Vibrio cholerae (gr... 301 8e-81
pir||A82558 glutamine amidotransferase XF2429 [imported] - Xylel... 300 2e-80
emb|CAA49847.1| (X70397) GMP synthase [Saccharomyces cerevisiae] 299 2e-80
gi|6323873 GMP synthase; Gua1p [Saccharomyces cerevisiae] >gi|17... 299 2e-80
sp|P46810|GUAA_MYCLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 295 5e-79
pir||G81971 probable GMP synthase (glutamine-hydrolyzing) (EC 6.... 293 2e-78
pir||D81026 GMP synthase NMB1920 [imported] - Neisseria meningit... 292 3e-78
gb|AAF09154.1|AC011622_11 (AC011622) GMP synthase; 61700-64653 [... 287 8e-77
pir||F71865 gmp synthetase - Helicobacter pylori (strain J99) >g... 286 2e-76
sp|O25165|GUAA_HELPY GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 286 3e-76
pir||G83173 GMP synthase PA3769 [imported] - Pseudomonas aerugin... 285 4e-76
pir||B75342 GMP synthase - Deinococcus radiodurans (strain R1) >... 284 7e-76
gi|11497008 GMP synthase (guaA) [Borrelia burgdorferi] >gi|39157... 284 1e-75
pir||I40246 GMP synthetase - Lyme disease spirochete >gi|495734|... 283 2e-75
gb|AAD24213.1| (AF086638) unknown [Pseudomonas putida GB-1] 280 1e-74
dbj|BAA89456.1| (AB003155) GMP synthetase [Corynebacterium ammon... 280 2e-74
emb|CAB88269.1| (AL353014) GMP synthase [glutamine-hydrolyzing] ... 271 9e-72
gb|AAK43326.1| GMP synthase, PP-ATPase domain (guaA) [Sulfolobus... 252 4e-66
gb|AAF09184.1|AF152349_1 (AF152349) GMP synthetase [Plasmodium f... 249 2e-65
sp|O52831|GUAA_CORAM GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 240 2e-62
pir||B72109 GMP synthase CP0599 [imported] - Chlamydophila pneum... 207 1e-52
gb|AAB02826.1| (U59112) ORFB; putative GMP synthase like-protein... 195 6e-49
gi|4504035 guanine monophosphate synthetase; guanosine 5'-monoph... 158 7e-38
sp|P32073|GUAA_DICDI GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTA... 155 4e-37
sp|Q09580|GUAA_CAEEL PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZIN... 154 1e-36
gb|AAF53975.1| (AE003669) CG9242 gene product [Drosophila melano... 146 3e-34
gi|11432448 guanine monphosphate synthetase [Homo sapiens] 121 9e-27
>pir||C75125 gmp synthase, cter domain PAB2417 - Pyrococcus abyssi (strain
Orsay) >gi|5458227|emb|CAB49716.1| (AJ248285) GMP
synthase, Cter domain [Pyrococcus abyssi]
Length = 308
Score = 614 bits (1567), Expect = e-175
Identities = 308/308 (100%), Positives = 308/308 (100%)
Query: 1 MNWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK 60
MNWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK
Sbjct: 1 MNWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK 60
Query: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG 120
GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG
Sbjct: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG 120
Query: 121 AEYLIQGTIAPDWIESQGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPE 180
AEYLIQGTIAPDWIESQGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPE
Sbjct: 121 AEYLIQGTIAPDWIESQGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPE 180
Query: 181 KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTV 240
KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTV
Sbjct: 181 KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTV 240
Query: 241 GVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNK 300
GVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNK
Sbjct: 241 GVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNK 300
Query: 301 PPATIEFE 308
PPATIEFE
Sbjct: 301 PPATIEFE 308
>pir||E71006 probable GMP synthase - Pyrococcus horikoshii
>gi|3257770|dbj|BAA30453.1| (AP000006) 308aa long
hypothetical GMP synthase [Pyrococcus horikoshii]
Length = 308
Score = 599 bits (1529), Expect = e-171
Identities = 298/308 (96%), Positives = 307/308 (98%)
Query: 1 MNWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK 60
M+W +FVEEKV+EIRETVGDSKAIIALSGGVDSSTAAVLA+KAIGD+LHAVFVNTGFLRK
Sbjct: 1 MDWGRFVEEKVREIRETVGDSKAIIALSGGVDSSTAAVLAHKAIGDRLHAVFVNTGFLRK 60
Query: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG 120
GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVA++IG
Sbjct: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAKKIG 120
Query: 121 AEYLIQGTIAPDWIESQGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPE 180
AEYLIQGTIAPDWIESQGKIKSHHNVGGLPE+LNLKLIEPLRDLYKDEVRELAKFLGLPE
Sbjct: 121 AEYLIQGTIAPDWIESQGKIKSHHNVGGLPEKLNLKLIEPLRDLYKDEVRELAKFLGLPE 180
Query: 181 KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTV 240
KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTV
Sbjct: 181 KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTV 240
Query: 241 GVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNK 300
GVQGDIRAYKETIAVRIVES+DGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNK
Sbjct: 241 GVQGDIRAYKETIAVRIVESIDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNK 300
Query: 301 PPATIEFE 308
PPATIEFE
Sbjct: 301 PPATIEFE 308
>pir||B64441 GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) - Methanococcus
jannaschii >gi|1592321|gb|AAB99133.1| (U67556) GMP
synthase (guaA) [Methanococcus jannaschii]
Length = 310
Score = 406 bits (1031), Expect = e-112
Identities = 206/307 (67%), Positives = 253/307 (82%), Gaps = 3/307 (0%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
+KF++E V+EI++ + D KAIIALSGGVDSS AAVL +KAIGDKL AVFV+TG +RKGE
Sbjct: 5 KKFIDEAVEEIKQQISDRKAIIALSGGVDSSVAAVLTHKAIGDKLTAVFVDTGLMRKGER 64
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAEY 123
E V KTFRD+ G+NL VDA+DRF +ALKGVTDPEEKRKIIG++FI+VFEE+A +I AE
Sbjct: 65 EEVEKTFRDKLGLNLIVVDAKDRFLNALKGVTDPEEKRKIIGKLFIDVFEEIAEDIKAEV 124
Query: 124 LIQGTIAPDWIESQGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPEKIY 183
L+QGTIAPDWIE+QGKIKSHHNV LP + L+++EPLR+LYKDEVR LAK LGLP+ I
Sbjct: 125 LVQGTIAPDWIETQGKIKSHHNV-ALPHGMVLEVVEPLRELYKDEVRLLAKELGLPDSIV 183
Query: 184 NRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAFAVLLGVKTVG 241
R PFPGPGLAVRV+GEVT EK+ I REANAIVEEEV++A L WQ FAV+L K G
Sbjct: 184 YRQPFPGPGLAVRVLGEVTEEKLNICREANAIVEEEVKKANLDKDLWQYFAVVLDCKATG 243
Query: 242 VQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKP 301
V+GD R Y +A+R+V+SLD MTA+ +P+++L+RI+ RITSEIP V RV++DIT+KP
Sbjct: 244 VKGDEREYNWIVALRMVKSLDAMTAHVPEIPFDLLKRISKRITSEIPNVARVVFDITDKP 303
Query: 302 PATIEFE 308
PATIEFE
Sbjct: 304 PATIEFE 310
>gi|11497869 GMP synthase (guaA-1) [Archaeoglobus fulgidus]
>gi|7483311|pir||E69281 GMP synthase (guaA-1) homolog -
Archaeoglobus fulgidus >gi|2650384|gb|AAB90977.1|
(AE001088) GMP synthase (guaA-1) [Archaeoglobus
fulgidus]
Length = 303
Score = 379 bits (962), Expect = e-104
Identities = 196/309 (63%), Positives = 240/309 (77%), Gaps = 7/309 (2%)
Query: 1 MNWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK 60
M+ EKFVE +KEIRE V D KAIIALSGGVDSS VLA+KA+GD+L VFV+TG +R+
Sbjct: 1 MDVEKFVENAIKEIRERVKDGKAIIALSGGVDSSVCTVLAHKALGDRLIPVFVDTGLMRE 60
Query: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG 120
GEPE + + F + M L ++DA++ FF ALKGVTDPEEKRK+IG +F+ +FE VA E
Sbjct: 61 GEPEKIKEIFGN---MGLVFIDAKEEFFKALKGVTDPEEKRKVIGELFVRIFERVAEEHN 117
Query: 121 AEYLIQGTIAPDWIESQGKIKSHHNVGGLPERLNLK-LIEPLRDLYKDEVRELAKFLGLP 179
AEYLIQGTI PD IESQG IKSHHNVGG P K +IEPLR+LYKDEVRE+A++LGLP
Sbjct: 118 AEYLIQGTIYPDIIESQGGIKSHHNVGGFPTSYKFKDVIEPLRELYKDEVREVARYLGLP 177
Query: 180 EKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKT 239
++I RMPFPGPGLAVR++GEVTPEK+ IVR+AN IVEEE+ A WQ FA L+G K
Sbjct: 178 KEISERMPFPGPGLAVRIVGEVTPEKVEIVRKANKIVEEEL--ADYDKWQCFAALIG-KA 234
Query: 240 VGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITN 299
GV+GD+R + IAVR VES DGMTA+ + + ++ L+RIA RIT EI +V RV+YDIT
Sbjct: 235 TGVKGDVRVWGYIIAVRAVESRDGMTADPIKIDYDRLRRIALRITGEIDKVSRVVYDITP 294
Query: 300 KPPATIEFE 308
KPPATIE+E
Sbjct: 295 KPPATIEYE 303
>pir||H69194 GMP synthetase, subunit B - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621797|gb|AAB85215.1| (AE000850)
GMP synthetase, subunit B [Methanobacterium
thermoautotrophicum]
Length = 311
Score = 377 bits (957), Expect = e-103
Identities = 190/309 (61%), Positives = 237/309 (76%), Gaps = 5/309 (1%)
Query: 1 MNWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK 60
+N F+EE V+EIR TVG+ KAIIALSGGVDSS A+VLA +AIGD L AVFV+ G LR+
Sbjct: 5 LNPSDFIEEAVEEIRSTVGNEKAIIALSGGVDSSVASVLAGRAIGDNLTAVFVDHGLLRE 64
Query: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG 120
GE E+V KTF + +N Y+DA + F L+GVTDPEEKRKIIGRVFIEVFE VA EIG
Sbjct: 65 GEAEYVRKTFSER--LNFRYIDASEEFLKELEGVTDPEEKRKIIGRVFIEVFERVAEEIG 122
Query: 121 AEYLIQGTIAPDWIESQGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPE 180
A YL+QGTIAPDWIES+G+IKSHHNV LP L L+++EP+R+LYKDEVRE+ LGLP
Sbjct: 123 ARYLVQGTIAPDWIESEGQIKSHHNV-ALPHGLVLEIVEPIRELYKDEVREIGLELGLPR 181
Query: 181 KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAFAVLLGVK 238
++ R PFPGPGLAVR++GE+T EKI I R ANAIVEEEV +GL WQ FAVL
Sbjct: 182 EMIQRQPFPGPGLAVRIVGEITREKIEICRRANAIVEEEVVESGLHESLWQYFAVLTDTM 241
Query: 239 TVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDIT 298
GV+GD+R + + +R+VESLD MTA+ +PW++++RI+ RIT+EIPEV V ++
Sbjct: 242 VTGVKGDVRDFGYLVVIRMVESLDAMTASVPELPWDLIKRISKRITAEIPEVTHVALSVS 301
Query: 299 NKPPATIEF 307
+KPP+TIEF
Sbjct: 302 DKPPSTIEF 310
>pir||G72206 GMP synthase - Thermotoga maritima (strain MSB8)
>gi|4982402|gb|AAD36883.1|AE001819_6 (AE001819) GMP
synthase [Thermotoga maritima]
Length = 501
Score = 362 bits (919), Expect = 3e-99
Identities = 186/317 (58%), Positives = 239/317 (74%), Gaps = 10/317 (3%)
Query: 2 NWE--KFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLR 59
NW+ VEEK++ I+ET+G+ KAI+ALSGGVDSS AAVL ++AIG L VFV+ G LR
Sbjct: 185 NWKIGDLVEEKIRHIKETIGNKKAILALSGGVDSSVAAVLVHRAIGKNLVCVFVDHGLLR 244
Query: 60 KGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI 119
K E E V + F++ F MNL VDA+ RF L+GVTDPE+KRKIIG FI VFEE A++
Sbjct: 245 KNEREEVERVFKEHFDMNLVVVDARKRFLEKLRGVTDPEKKRKIIGEEFIRVFEEEAKKH 304
Query: 120 GAEYLIQGTIAPDWIES------QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELA 173
E+L+QGTI D IES KIKSHHNVGGLPE++NLKL+EPLRDL+KDEVR++
Sbjct: 305 DVEFLVQGTIYSDVIESAASGKTTAKIKSHHNVGGLPEKMNLKLVEPLRDLFKDEVRKVG 364
Query: 174 KFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAF 231
K+LG+P++I NR PFPGPGLAVRV+GEVT EK+ I+REA+ I E + + + WQAF
Sbjct: 365 KYLGIPDRIINRHPFPGPGLAVRVLGEVTEEKLEILREADYIFIETLRKHDYYDKVWQAF 424
Query: 232 AVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVG 291
AVLL +K+VGV+GD RAY+ +A+R V S++GMTA+ +P ++L A RIT E+ VG
Sbjct: 425 AVLLPIKSVGVKGDARAYEYVVALRAVNSVEGMTADWSRIPHDILDEAARRITREVKGVG 484
Query: 292 RVLYDITNKPPATIEFE 308
RV+YDIT+KPPATIE+E
Sbjct: 485 RVVYDITSKPPATIEWE 501
>sp|O66601|GUAA_AQUAE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|7438057|pir||E70321 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) - Aquifex aeolicus
>gi|2982942|gb|AAC06558.1| (AE000679) GMP synthase
[Aquifex aeolicus]
Length = 510
Score = 359 bits (912), Expect = 2e-98
Identities = 184/317 (58%), Positives = 241/317 (75%), Gaps = 11/317 (3%)
Query: 2 NWEK--FVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLR 59
NWE F+ EK++EIR+TVGD+K I ALSGGVDS+ AAVL ++AIGDKLH F++ G LR
Sbjct: 195 NWEMGDFIHEKIEEIRKTVGDAKVIAALSGGVDSTVAAVLTHRAIGDKLHCFFIDHGLLR 254
Query: 60 KGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI 119
E E V K R G+ L VDA + F LKGV DPEEKRKIIGR FIEVFE A++I
Sbjct: 255 YKEREEVEKNLRS-LGLPLTVVDASEEFLEKLKGVEDPEEKRKIIGRTFIEVFEREAKKI 313
Query: 120 -GAEYLIQGTIAPDWIESQG-----KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELA 173
GAE+L+QGT+ PD +ES G KIK+HHNVGGLPER+NLKL+EP R+L+KDEVR++
Sbjct: 314 EGAEFLLQGTLYPDVVESAGIKGSAKIKTHHNVGGLPERMNLKLLEPFRELFKDEVRKIG 373
Query: 174 KFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAF 231
K LG+PE+I R PFPGPGLA+R+IGEV + + I+R+A+ I +E+++ GL R WQAF
Sbjct: 374 KLLGVPEEILRRHPFPGPGLAIRIIGEVNKKDLEILRKADYIFIQELKKEGLYDRVWQAF 433
Query: 232 AVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVG 291
AVLL VK+VGV GD+R Y++ +A+R VES+DGMTA+ +P++ L R+ RI +E+ V
Sbjct: 434 AVLLPVKSVGVMGDVRTYEKVVALRAVESVDGMTADWARLPYDFLDRVMRRIINEVEGVN 493
Query: 292 RVLYDITNKPPATIEFE 308
RV+YDI++KPP+TIE+E
Sbjct: 494 RVVYDISSKPPSTIEWE 510
>gb|AAG20037.1| (AE005084) GMP synthase subunit B; GuaAb [Halobacterium sp. NRC-1]
Length = 305
Score = 356 bits (905), Expect = 1e-97
Identities = 186/306 (60%), Positives = 226/306 (73%), Gaps = 6/306 (1%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
+ FVE+ EI E +GD AIIALSGGVDSSTAA LAY+A+GD+L V+V+TG +RKGE
Sbjct: 5 DSFVEDARAEISEALGDETAIIALSGGVDSSTAAALAYEAVGDQLVPVYVDTGLMRKGET 64
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAEY 123
+ + + F ++ +L VDA DRFF L GVTDPEEKR IG FI FE VA E+ A
Sbjct: 65 DEIREVF--DYMDSLRVVDASDRFFDELAGVTDPEEKRHAIGEQFIREFETVAEEVDATQ 122
Query: 124 LIQGTIAPDWIESQGKIKSHHNVGGLPERLNLK-LIEPLRDLYKDEVRELAKFLGLPEKI 182
L+QGTI PD IES+G IKSHHNVGGLPER+ + ++EP+RDLYKDEVRE+A+ LGL E I
Sbjct: 123 LVQGTIYPDRIESEGTIKSHHNVGGLPERVGFEGIVEPMRDLYKDEVREVARHLGLEEII 182
Query: 183 YNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTVGV 242
RMPFPGPGLAVRVIGEVTPEK+ + REA IVE+E+E PWQAFA +LG + GV
Sbjct: 183 SERMPFPGPGLAVRVIGEVTPEKVAVCREATHIVEDELE--AYEPWQAFAAVLG-RATGV 239
Query: 243 QGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPP 302
+GD R + +AVR VES DGMTA A + WE LQR+ RI I EV RV+YD+T+KPP
Sbjct: 240 KGDNRVHGHVVAVRSVESRDGMTARAQELEWETLQRLQSRIAGTIDEVSRVVYDVTHKPP 299
Query: 303 ATIEFE 308
ATIE+E
Sbjct: 300 ATIEYE 305
>sp|P49057|GUAA_SYNY3 PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE
AMIDOTRANSFERASE) (GMP SYNTHETASE)
>gi|7438055|pir||S76358 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) - Synechocystis sp.
(strain PCC 6803) >gi|1001583|dbj|BAA10210.1| (D64000)
GMP synthetase [Synechocystis sp.]
Length = 542
Score = 342 bits (869), Expect = 2e-93
Identities = 169/319 (52%), Positives = 232/319 (71%), Gaps = 16/319 (5%)
Query: 6 FVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEF 65
F+EE ++E+R VGD + ++ALSGGVDSST A L ++AIGD L +F++ GF+RKGEPE
Sbjct: 224 FIEESIREVRSQVGDRRVLLALSGGVDSSTLAFLLHRAIGDNLTCMFIDQGFMRKGEPER 283
Query: 66 VVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGA-EYL 124
+V+ F +F + + YV+A+DRF L+GVTDPEEKR++IG FI+VFEE + +G +YL
Sbjct: 284 LVELFDHQFHIPVQYVNARDRFLKQLEGVTDPEEKRRLIGHEFIQVFEEESNRLGPFDYL 343
Query: 125 IQGTIAPDWIESQG-------------KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRE 171
QGT+ PD IES KIKSHHNVGGLP+ L KL+EPLR L+KDEVR+
Sbjct: 344 AQGTLYPDVIESADSNVDPKTGERVAVKIKSHHNVGGLPKNLRFKLVEPLRKLFKDEVRK 403
Query: 172 LAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQ 229
L + +GLPE+I R PFPGPGLA+R+IGEVT E++ I+R+A+ IV +E+ + G+ WQ
Sbjct: 404 LGRSIGLPEEIVRRHPFPGPGLAIRIIGEVTSERLNILRDADFIVRDEISKRGIYHDYWQ 463
Query: 230 AFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPE 289
AFAVLL +++VGV GD R Y + +R + S DGMTA+ VP+++L+ I+ RI +E+
Sbjct: 464 AFAVLLPIRSVGVMGDKRTYAHPVVLRFITSEDGMTADWARVPYDILEAISNRIVNEVKG 523
Query: 290 VGRVLYDITNKPPATIEFE 308
V RV+YDIT+KPP TIE+E
Sbjct: 524 VNRVVYDITSKPPGTIEWE 542
>emb|CAC12482.1| (AL445067) probable GMP synthase [Thermoplasma acidophilum]
Length = 310
Score = 339 bits (859), Expect = 3e-92
Identities = 177/315 (56%), Positives = 227/315 (71%), Gaps = 12/315 (3%)
Query: 1 MNWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK 60
M+ ++++ EI E V +AIIA+SGG DSS +VLA + +GD+L VFV+TG +R
Sbjct: 1 MSTSSYIDQIKNEISEKV-KGRAIIAVSGGQDSSLLSVLASQVLGDRLLCVFVDTGLIRI 59
Query: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG 120
GE + V K F +E MN VDA RF ALKG+TDPEEKRKIIG++FI+V E A
Sbjct: 60 GEVDRVRKFF-EEHAMNYRIVDASKRFLEALKGITDPEEKRKIIGKMFIDVLNEEAENFH 118
Query: 121 AEYLIQGTIAPDWIESQGK----IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFL 176
AEYL+QGTIAPDWIES G+ IKSHHNVGGLP+ + LKL+EPLRD YKDE+R +++ L
Sbjct: 119 AEYLLQGTIAPDWIESGGQKRDTIKSHHNVGGLPKEMKLKLVEPLRDFYKDEIRAMSREL 178
Query: 177 GLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERA---GLRPWQAFAV 233
GL + PFPGPGLAVR++GE+TPEK+ ++R A IVE+++E A RPWQ FAV
Sbjct: 179 GLRTDL---QPFPGPGLAVRIVGEITPEKLDLLRRATRIVEDKIESALKPEERPWQYFAV 235
Query: 234 LLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRV 293
LL VKT GV GD RAY T+AVR+++S+D MT W++L+ IA IT EIP++ RV
Sbjct: 236 LLPVKTTGVHGDRRAYGYTVAVRMIDSIDAMTGTFTKPSWDLLEDIANTITDEIPDINRV 295
Query: 294 LYDITNKPPATIEFE 308
+YDITNKPPATIE+E
Sbjct: 296 VYDITNKPPATIEWE 310
>dbj|BAB04326.1| (AP001509) GMP synthetase [Bacillus halodurans]
Length = 513
Score = 338 bits (857), Expect = 6e-92
Identities = 171/316 (54%), Positives = 232/316 (73%), Gaps = 9/316 (2%)
Query: 2 NW--EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLR 59
NW E F+E ++++IRE VGD + + ALSGGVDSS AVL +KAIGD+L +F++ G LR
Sbjct: 198 NWSMENFIELEMEKIREQVGDKQVLCALSGGVDSSVVAVLIHKAIGDQLTCMFIDHGLLR 257
Query: 60 KGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI 119
KGE + V+KTF + F MN+ +DA+DRF S L+GV+DPE+KRKIIG FI VFEE A ++
Sbjct: 258 KGEADSVMKTFSEGFNMNVIKIDAKDRFLSKLEGVSDPEQKRKIIGNEFIYVFEEEASKL 317
Query: 120 -GAEYLIQGTIAPDWIES----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAK 174
++L QGT+ D IES IKSHHNVGGLPE + +LIEPL L+KDEVR+L
Sbjct: 318 KDMDFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMRFELIEPLNTLFKDEVRKLGT 377
Query: 175 FLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFA 232
LG+P+++ R PFPGPGL +RV+GE+T EK+ IVRE++AI+ EE+++AGL WQ F
Sbjct: 378 ELGIPDEVVWRQPFPGPGLGIRVLGEITEEKLEIVRESDAILREEIKKAGLDREIWQYFT 437
Query: 233 VLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGR 292
L +++VGV GD R Y T+ +R V S+DGMT++ +PW+VL+ I+ RI +E+ V R
Sbjct: 438 ALPNMRSVGVMGDARTYDYTVGIRAVTSIDGMTSDWARIPWDVLEIISTRIVNEVKHVNR 497
Query: 293 VLYDITNKPPATIEFE 308
V+YDIT+KPPATIE+E
Sbjct: 498 VVYDITSKPPATIEWE 513
>gb|AAC33274.1| (AF051937) GMP synthetase [Lactobacillus rhamnosus]
Length = 517
Score = 333 bits (845), Expect = 2e-90
Identities = 171/316 (54%), Positives = 228/316 (72%), Gaps = 9/316 (2%)
Query: 2 NW--EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLR 59
NW + F+ +++ +IR VGD + ++ LSGGVDSS VL +KAIG +L ++FV+ G LR
Sbjct: 202 NWSMDDFITKQIAKIRAEVGDKRVLLGLSGGVDSSVVGVLLHKAIGTQLTSIFVDHGLLR 261
Query: 60 KGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVF-EEVARE 118
KGE E V+ + + +FG+N+ V+A+DRF + L+GVTDPE+KRKIIGR FIEVF EE A+
Sbjct: 262 KGEAEQVMDSLKGKFGLNIIKVNAKDRFLNDLRGVTDPEKKRKIIGRDFIEVFNEEAAKL 321
Query: 119 IGAEYLIQGTIAPDWIES----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAK 174
G E+L QGT+ D +ES IKSHHNVGGLPE L KLIEPL L+KDEVREL +
Sbjct: 322 NGIEFLAQGTLYTDVVESGTDTAQTIKSHHNVGGLPEDLKFKLIEPLNKLFKDEVRELGE 381
Query: 175 FLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAFA 232
LG+P + R PFPGPGL +RVIGEVT +K+ IVR+++ I+ EE+ + GL WQ F
Sbjct: 382 KLGMPHSLVWRQPFPGPGLGIRVIGEVTEDKLEIVRDSDYILREEIAKHGLDKDIWQYFT 441
Query: 233 VLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGR 292
VL G+++VGV GD R Y TI +R + S+DGMTA+ + W+VLQ I+ RI +E+ V R
Sbjct: 442 VLPGIRSVGVMGDGRTYDYTIGIRAITSIDGMTADFARIDWDVLQEISSRIVNEVKHVNR 501
Query: 293 VLYDITNKPPATIEFE 308
V+YDIT+KPPATIE+E
Sbjct: 502 VVYDITSKPPATIEWE 517
>sp|P29727|GUAA_BACSU GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|7428511|pir||C69638 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) guaA - Bacillus
subtilis >gi|2239288|gb|AAB62311.1| (U51115) GMP
synthetase [Bacillus subtilis]
>gi|2632949|emb|CAB12455.1| (Z99107) GMP synthetase
[Bacillus subtilis]
Length = 513
Score = 332 bits (843), Expect = 3e-90
Identities = 174/312 (55%), Positives = 227/312 (71%), Gaps = 8/312 (2%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
E F+E ++++IRETVGD + + ALSGGVDSS AVL +KAIGD+L +FV+ G LRKGE
Sbjct: 203 ENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEA 262
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAE 122
E V+KTF + F MN+ VDA+DRF + LKGV+DPE+KRKIIG FI VF++ A ++ G +
Sbjct: 263 EGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGID 322
Query: 123 YLIQGTIAPDWIES----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGL 178
YL QGT+ D IES IKSHHNVGGLPE + +LIEPL L+KDEVR L LG+
Sbjct: 323 YLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGI 382
Query: 179 PEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAFAVLLG 236
P++I R PFPGPGL +RV+GEVT EK+ IVRE++AI+ EE+ GL WQ F VL
Sbjct: 383 PDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPD 442
Query: 237 VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYD 296
+++VGV GD R Y TI R S+DGMT++ +PW+VL+ I+ RI +E+ + RV+YD
Sbjct: 443 IRSVGVMGDARTYDYTIESRRT-SIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYD 501
Query: 297 ITNKPPATIEFE 308
IT+KPPATIE+E
Sbjct: 502 ITSKPPATIEWE 513
>pir||C72476 probable GMP synthase APE2452 - Aeropyrum pernix (strain K1)
>gi|5106156|dbj|BAA81467.1| (AP000064) 512aa long
hypothetical GMP synthase [Aeropyrum pernix]
Length = 512
Score = 332 bits (842), Expect = 3e-90
Identities = 176/309 (56%), Positives = 226/309 (72%), Gaps = 8/309 (2%)
Query: 7 VEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFV 66
V E V+ +++ VGD+ A+ A+SGGVDS+ AA++A KAIG +L+ VF++ G +GE E V
Sbjct: 205 VSELVESVKKEVGDALAVAAVSGGVDSTVAALIAKKAIGSRLYPVFIDHGLHPEGEVERV 264
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAEYLIQ 126
VK G+ VDA + F +AL+GV DPEEKR+++GRV+ EV E AR+IGAEYL+Q
Sbjct: 265 VKLL-SRLGLEPVMVDAGEEFLAALEGVGDPEEKRRVVGRVYAEVLERAARDIGAEYLVQ 323
Query: 127 GTIAPDWIESQGK-----IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPEK 181
GTI PD IES + IK+HHNVGGLP+ + LKL+EPLR YKDEVR LA+ LG+P +
Sbjct: 324 GTIYPDVIESGARPGADTIKTHHNVGGLPKDMRLKLVEPLRYFYKDEVRLLAEKLGVPRE 383
Query: 182 IYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVLLGVKT 239
+ + P PGPGLAVRV G +T EK+RIVR A+AIV EEVE AGL + WQ FAVL
Sbjct: 384 LIWKQPVPGPGLAVRVEGPITREKLRIVRRADAIVREEVEAAGLGGKLWQYFAVLTASMA 443
Query: 240 VGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITN 299
GV+GD R+Y +AVR VES+D MTA +PW +L+RIA RITSEIPEV RV+YDIT+
Sbjct: 444 TGVRGDSRSYGYVVAVRAVESVDAMTAKPAELPWWLLERIARRITSEIPEVVRVVYDITS 503
Query: 300 KPPATIEFE 308
KPP+TIE+E
Sbjct: 504 KPPSTIEWE 512
>pir||B42280 GMP synthetase - Bacillus subtilis
Length = 513
Score = 328 bits (832), Expect = 5e-89
Identities = 172/312 (55%), Positives = 225/312 (71%), Gaps = 8/312 (2%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
E F+E ++++IRE VGD + + LSGGVDSS AVL +KAIGD+L +FV+ G LRKGE
Sbjct: 203 ENFIEIEMQKIREQVGDKQVLCGLSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGER 262
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAE 122
E V+KTF + F MN+ VDA+DRF + LKGV+DPE+KRKIIG FI VF++ A ++ G +
Sbjct: 263 EGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGID 322
Query: 123 YLIQGTIAPDWIES----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGL 178
YL QGT+ D IES IKSHHNVGGLPE + +LIEPL L+KDEVR L LG+
Sbjct: 323 YLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGI 382
Query: 179 PEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAFAVLLG 236
P++I R PFPGPGL +RV+GEVT EK+ IVRE++AI+ EE+ GL WQ F VL
Sbjct: 383 PDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPD 442
Query: 237 VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYD 296
+++VGV GD R Y TI R S+DGMT++ +PW+VL+ I+ RI +E+ + RV+YD
Sbjct: 443 IRSVGVMGDARTYDYTIESRRT-SIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYD 501
Query: 297 ITNKPPATIEFE 308
IT+KPPATIE+E
Sbjct: 502 ITSKPPATIEWE 513
>gb|AAA22497.1| (M83691) GMP synthetase [Bacillus subtilis]
Length = 513
Score = 328 bits (832), Expect = 5e-89
Identities = 172/312 (55%), Positives = 225/312 (71%), Gaps = 8/312 (2%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
E F+E ++++IRE VGD + + LSGGVDSS AVL +KAIGD+L +FV+ G LRKGE
Sbjct: 203 ENFIEIEMQKIREQVGDKQVLCGLSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGER 262
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAE 122
E V+KTF + F MN+ VDA+DRF + LKGV+DPE+KRKIIG FI VF++ A ++ G +
Sbjct: 263 EGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGID 322
Query: 123 YLIQGTIAPDWIES----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGL 178
YL QGT+ D IES IKSHHNVGGLPE + +LIEPL L+KDEVR L LG+
Sbjct: 323 YLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGI 382
Query: 179 PEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAFAVLLG 236
P++I R PFPGPGL +RV+GEVT EK+ IVRE++AI+ EE+ GL WQ F VL
Sbjct: 383 PDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPD 442
Query: 237 VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYD 296
+++VGV GD R Y TI R S+DGMT++ +PW+VL+ I+ RI +E+ + RV+YD
Sbjct: 443 IRSVGVMGDARTYDYTIESRRT-SIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYD 501
Query: 297 ITNKPPATIEFE 308
IT+KPPATIE+E
Sbjct: 502 ITSKPPATIEWE 513
>gb|AAD15805.1| (AF058326) GMP synthase [Lactococcus lactis]
Length = 513
Score = 328 bits (831), Expect = 7e-89
Identities = 164/316 (51%), Positives = 228/316 (71%), Gaps = 9/316 (2%)
Query: 2 NW--EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLR 59
NW E F++ ++K+IRE VGD K ++ LSGGVDSS VL +AIGD+L ++FV+ GFLR
Sbjct: 198 NWSMENFIDMQIKDIREKVGDKKVLLGLSGGVDSSVVGVLLQRAIGDQLTSIFVDHGFLR 257
Query: 60 KGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI 119
KGE + V++T +FG+N+ VDAQ RF L G++DPE +RKIIG F+ VF++ A ++
Sbjct: 258 KGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETQRKIIGNEFVYVFDDEANKL 317
Query: 120 -GAEYLIQGTIAPDWIES----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAK 174
G ++L QGT+ D IES IKSHHNVGGLPE + +LIEPL L+KDEVR L
Sbjct: 318 EGVDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGT 377
Query: 175 FLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLR--PWQAFA 232
LG+P++I R PFPGPGLA+RV+G++T EK+ VRE++AI+ EE+ +GL WQ F
Sbjct: 378 QLGMPDEIVWRQPFPGPGLAIRVLGDLTEEKLETVRESDAILREEIAASGLERDVWQYFT 437
Query: 233 VLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGR 292
V VK+VGV GD R Y T+A+R + S+DGMTA+ +PW++LQ+I+ RI +E+ V R
Sbjct: 438 VNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDLLQKISKRIVNEVDHVNR 497
Query: 293 VLYDITNKPPATIEFE 308
++YDIT+KPPAT+E++
Sbjct: 498 IVYDITSKPPATVEWQ 513
>emb|CAB82024.1| (AL161755) GMP synthase [Streptomyces coelicolor A3(2)]
Length = 526
Score = 313 bits (794), Expect = 1e-84
Identities = 170/316 (53%), Positives = 220/316 (68%), Gaps = 14/316 (4%)
Query: 7 VEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFV 66
+EE+V IR VGD +AI LSGGVDS+ AA L KAIG +L V+V+ G +RKGE E V
Sbjct: 211 IEEQVAAIRAQVGDRRAICGLSGGVDSAVAAALVQKAIGSQLTCVYVDHGLMRKGETEQV 270
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFE----EVAREIGAE 122
K F G+ L VDA +RF AL GV+DPE+KRKIIGR FI VFE E+ RE G E
Sbjct: 271 EKDFVAATGVQLKVVDASERFLGALAGVSDPEQKRKIIGREFIRVFEQAQLEIMREDGPE 330
Query: 123 --YLIQGTIAPDWIESQG-----KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKF 175
+L+QGT+ PD +ES G IKSHHNVGGLP+ + +L+EPLR L+KDEVR + +
Sbjct: 331 VAFLVQGTLYPDVVESGGGTGTANIKSHHNVGGLPDDIEFELVEPLRQLFKDEVRMVGQE 390
Query: 176 LGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAFAV 233
LGLP++I R PFPGPGL +R++GEVT E++ ++REA+AI EE+ AGL WQ V
Sbjct: 391 LGLPDEIVQRQPFPGPGLGIRIVGEVTKERLDLLREADAIAREELTAAGLDRDIWQCPVV 450
Query: 234 LLG-VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGR 292
LL V++VGVQGD R Y I +R V S D MTA+ +P+EVL +I+ RIT+E+ +V R
Sbjct: 451 LLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWSRLPYEVLSKISTRITNEVTDVNR 510
Query: 293 VLYDITNKPPATIEFE 308
V+ D+T+KPP TIE+E
Sbjct: 511 VVLDVTSKPPGTIEWE 526
>sp|P44335|GUAA_HAEIN GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|1074169|pir||I64055 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) - Haemophilus
influenzae (strain Rd KW20) >gi|1573186|gb|AAC21891.1|
(U32708) GMP synthase (guaA) [Haemophilus influenzae Rd]
Length = 523
Score = 305 bits (773), Expect = 4e-82
Identities = 158/315 (50%), Positives = 223/315 (70%), Gaps = 10/315 (3%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
E +E+ V I+E VGD + I+ LSGGVDSS A+L ++AIG LH VFV+ G LR E
Sbjct: 209 ENIIEDAVARIKEQVGDDEVILGLSGGVDSSVVALLLHRAIGKNLHCVFVDNGLLRLHEG 268
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAE 122
+ V++ F D+FG+N+ VDA+ RF L GV+DPE KRKIIG+VF++VF++ ++++ +
Sbjct: 269 DQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDESKKLTNVK 328
Query: 123 YLIQGTIAPDWIESQGK-------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKF 175
+L QGTI PD IES IKSHHNVGGLP+ + L L+EPLR+L+KDEVR++
Sbjct: 329 WLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLA 388
Query: 176 LGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAV 233
LGLP ++ NR PFPGPGL VRV+GEV E ++R A+AI EE+ +G + QAF+V
Sbjct: 389 LGLPAEMINRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSV 448
Query: 234 LLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRV 293
L VK+VGV GD R Y I++R VE++D MTA+ ++P+++L +++ RI +E+ + RV
Sbjct: 449 FLPVKSVGVMGDGRKYDWVISLRAVETIDFMTAHWAHLPYDLLGKVSNRIINEVNGISRV 508
Query: 294 LYDITNKPPATIEFE 308
+YDI+ KPPATIE+E
Sbjct: 509 VYDISGKPPATIEWE 523
>pir||T31103 probable GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) -
Haemophilus ducreyi (fragment)
>gi|3929020|gb|AAC79759.1| (AF057695) putative GMP
synthase [Haemophilus ducreyi]
Length = 368
Score = 304 bits (770), Expect = 9e-82
Identities = 155/315 (49%), Positives = 226/315 (71%), Gaps = 10/315 (3%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
E +E+ V +I++ VG+ + I+ LSGGVDSS A+L ++AIG LH VFV+ G LR E
Sbjct: 54 ENIIEDAVAKIKQKVGNDQVILGLSGGVDSSVTALLLHRAIGKNLHCVFVDNGLLRLNEG 113
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAE 122
+ V++ F D+FG+N+ V+A++RF ALKG+ +PE KRKIIG+VFI++F++ A+++ +
Sbjct: 114 DQVMEMFGDKFGLNIIRVNAEERFLEALKGIDEPEAKRKIIGKVFIDIFDDEAKKLTDVK 173
Query: 123 YLIQGTIAPDWIESQGK-------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKF 175
+L QGTI PD IES IKSHHNVGGLP+ + L L+EPLR+L+KDEVR++
Sbjct: 174 WLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLT 233
Query: 176 LGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAG--LRPWQAFAV 233
LGLP ++ NR PFPGPGL VRV+GE+ E ++R A+AI EE+ ++G + QAF V
Sbjct: 234 LGLPAEMLNRHPFPGPGLGVRVLGEIKKEYCDLLRNADAIFIEELYKSGWYYKVSQAFTV 293
Query: 234 LLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRV 293
L VK+VGV GD R Y +++R VE++D MTA+ ++P+E+L +I+ RI +E+ + RV
Sbjct: 294 FLPVKSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYELLGKISNRIINEVNGISRV 353
Query: 294 LYDITNKPPATIEFE 308
+YD++ KPPATIE+E
Sbjct: 354 VYDVSGKPPATIEWE 368
>pir||B81332 GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) Cj1248 [imported]
- Campylobacter jejuni (strain NCTC 11168)
>gi|6968681|emb|CAB73502.1| (AL139077) GMP synthase
(glutamine-hydrolyzing) [Campylobacter jejuni]
Length = 511
Score = 303 bits (769), Expect = 1e-81
Identities = 157/315 (49%), Positives = 219/315 (68%), Gaps = 8/315 (2%)
Query: 2 NWEKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKG 61
N F + + ++IRE VG+ K + A+SGGVDSS A L AI +++ VFV+ G LR G
Sbjct: 197 NMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIKEQIIVVFVDNGLLRSG 256
Query: 62 EPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVARE-IG 120
E E V F++ G++L +DA + F S L VTDPE+KRKIIG FIEVFEE A++
Sbjct: 257 EKEQVEFMFKNTLGIDLISIDASEIFLSRLVNVTDPEQKRKIIGNTFIEVFEEEAKKHKD 316
Query: 121 AEYLIQGTIAPDWIES-----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKF 175
+YL QGT+ D IES IKSHHNVGGLPE++NLKLIEPL++++KDEVR L
Sbjct: 317 VKYLAQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLE 376
Query: 176 LGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAV 233
LGL +++ R PFPGPGLA+R++GEV + ++R+A+ I+ EE++ G + WQAF V
Sbjct: 377 LGLSKEVVYRHPFPGPGLAIRIMGEVNRASLELLRKADVILLEELKSTGWYDKTWQAFCV 436
Query: 234 LLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRV 293
LL VK+VGV GD R Y + +R+V++ DGMTA ++P+E+L+ I+ RI +E+ + RV
Sbjct: 437 LLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEILENISRRIINEVEGINRV 496
Query: 294 LYDITNKPPATIEFE 308
+YDI++KPPATIE+E
Sbjct: 497 VYDISSKPPATIEWE 511
>pir||D81701 GMP synthase TC0442 [imported] - Chlamydia muridarum (strain Nigg)
>gi|7190487|gb|AAF39296.1| (AE002313) GMP synthase
[Chlamydia muridarum]
Length = 512
Score = 303 bits (769), Expect = 1e-81
Identities = 167/314 (53%), Positives = 220/314 (69%), Gaps = 10/314 (3%)
Query: 4 EKFVEEKVKEIRETVGDS-KAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGE 62
E ++ ++ IRE VG++ + ++ LSGGVDSS AVL + A+GD+L VFV+TG LRK E
Sbjct: 200 ETIEKQLIQGIREKVGETERVLLGLSGGVDSSVLAVLLHNALGDRLSCVFVDTGLLRKNE 259
Query: 63 PEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAE 122
E V + F G+ + VDA ++FF L G+ DPE+KRK+IG FIEVF+E ++ + +
Sbjct: 260 VEEVKQQF-SSLGLEILVVDASEKFFHDLSGIEDPEQKRKVIGAAFIEVFDEASKNLDVQ 318
Query: 123 YLIQGTIAPDWIESQGK------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFL 176
+L QGTI D IES IKSHHNVGGLPE+LNLKL+EPLR L+KDEVR L K L
Sbjct: 319 WLAQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVL 378
Query: 177 GLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVL 234
GLP+ + +R PFPGPGL VRV+GEV E + IV+ A++I EE+++A L + QAFAV
Sbjct: 379 GLPDVLISRHPFPGPGLGVRVLGEVRREYVEIVKNADSIFIEELKKANLYHKVSQAFAVF 438
Query: 235 LGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVL 294
L K+V V+GD R Y TIA+R VES D MTA ++ E L R + RI +EIPEV RV+
Sbjct: 439 LPCKSVAVKGDCRHYGYTIALRAVESTDFMTACWPSLSREFLNRCSSRIINEIPEVCRVV 498
Query: 295 YDITNKPPATIEFE 308
YDI++KPPATIE+E
Sbjct: 499 YDISDKPPATIEWE 512
>sp|P04079|GUAA_ECOLI GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|68651|pir||SYECGU GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) [validated] -
Escherichia coli >gi|1310841|pdb|1GPM|A Chain A,
Escherichia Coli Gmp Synthetase Complexed With Amp And
Pyrophosphate >gi|1310843|pdb|1GPM|C Chain C,
Escherichia Coli Gmp Synthetase Complexed With Amp And
Pyrophosphate >gi|1310842|pdb|1GPM|B Chain B,
Escherichia Coli Gmp Synthetase Complexed With Amp And
Pyrophosphate >gi|1310844|pdb|1GPM|D Chain D,
Escherichia Coli Gmp Synthetase Complexed With Amp And
Pyrophosphate >gi|146276|gb|AAB18619.1| (M10101) GMP
synthetase [Escherichia coli] >gi|1788854|gb|AAC75560.1|
(AE000337) GMP synthetase (glutamine-hydrolyzing)
[Escherichia coli K12] >gi|1805567|dbj|BAA16394.1|
(D90880) GMP synthase (glutamine-hydrolyzing) (EC
6.3.5.2) [Escherichia coli]
Length = 525
Score = 302 bits (764), Expect = 5e-81
Identities = 161/314 (51%), Positives = 217/314 (68%), Gaps = 10/314 (3%)
Query: 5 KFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPE 64
K +++ V IRE VGD K I+ LSGGVDSS A+L ++AIG L VFV+ G LR E E
Sbjct: 212 KIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAE 271
Query: 65 FVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAEY 123
V+ F D FG+N+ +V A+DRF SAL G DPE KRKIIGRVF+EVF+E A ++ ++
Sbjct: 272 QVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKW 331
Query: 124 LIQGTIAPDWIESQGK-------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFL 176
L QGTI PD IES IKSHHNVGGLP+ + + L+EPL++L+KDEVR++ L
Sbjct: 332 LAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLEL 391
Query: 177 GLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVL 234
GLP + R PFPGPGL VRV+GEV E ++R A+AI EE+ +A L + QAF V
Sbjct: 392 GLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVF 451
Query: 235 LGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVL 294
L V++VGV GD R Y +++R VE++D MTA+ ++P++ L R++ RI +E+ + RV+
Sbjct: 452 LPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVV 511
Query: 295 YDITNKPPATIEFE 308
YDI+ KPPATIE+E
Sbjct: 512 YDISGKPPATIEWE 525
>sp|Q50729|GUAA_MYCTU GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|7438058|pir||A70735 probable guaA
protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1449391|emb|CAB01027.1| (Z77165) guaA [Mycobacterium
tuberculosis]
Length = 525
Score = 301 bits (762), Expect = 8e-81
Identities = 165/310 (53%), Positives = 212/310 (68%), Gaps = 12/310 (3%)
Query: 11 VKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFVVKTF 70
++++R +GD AI LSGGVDS+ AA L +AIGD+L VFV+ G LR GE V + F
Sbjct: 216 IEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDF 275
Query: 71 RDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI----GAEYLIQ 126
G NL VDA + F AL GV+ PE KRKIIGR FI FE R++ AE+L+Q
Sbjct: 276 VAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQ 335
Query: 127 GTIAPDWIESQG-----KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPEK 181
GT+ PD +ES G IKSHHNVGGLP+ L L+EPLR L+KDEVR + + LGLPE+
Sbjct: 336 GTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEE 395
Query: 182 IYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVLLG-VK 238
I R PFPGPGL +R++GEVT +++ +R A++IV EE+ AGL + WQ VLL V+
Sbjct: 396 IVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVR 455
Query: 239 TVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDIT 298
+VGVQGD R Y I +R V S D MTA+ VP+EVL+RI+ RIT+E+ EV RV+ DIT
Sbjct: 456 SVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVNRVVLDIT 515
Query: 299 NKPPATIEFE 308
+KPPATIE+E
Sbjct: 516 SKPPATIEWE 525
>pir||D82282 GMP synthase VC0768 [imported] - Vibrio cholerae (group O1 strain
N16961) >gi|9655215|gb|AAF93933.1| (AE004162) GMP
synthase [Vibrio cholerae]
Length = 517
Score = 301 bits (762), Expect = 8e-81
Identities = 158/315 (50%), Positives = 221/315 (70%), Gaps = 10/315 (3%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
E +E+ V I+E VG+ + I+ LSGGVDSS A+L ++AIG KL VFV+ G LR E
Sbjct: 203 ESIIEDAVARIKEQVGNDEVILGLSGGVDSSVVAMLVHRAIGSKLTCVFVDNGLLRLNEG 262
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAE 122
E V++ F D+FG+N+ VDA++RF AL+G+ +PE KRK IGRVF+EVF+E ++++ A+
Sbjct: 263 EQVMEMFGDKFGLNIIKVDAEERFLKALEGIDEPEAKRKTIGRVFVEVFDEESKKLSNAK 322
Query: 123 YLIQGTIAPDWIESQGK-------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKF 175
+L QGTI PD IES IKSHHNVGGLP+ + + L+EPLR+L+KDEVR++
Sbjct: 323 WLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDMKMGLVEPLRELFKDEVRKIGLE 382
Query: 176 LGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAV 233
LGLP + R PFPGPGL VRV+GEV E ++R A+AI EE+ A L + QAF V
Sbjct: 383 LGLPYNMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHAADLYNKVSQAFTV 442
Query: 234 LLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRV 293
L V++VGV GD R Y +++R VE++D MTA+ ++P+E L +++ RI +E+ + RV
Sbjct: 443 FLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYEFLGKVSNRIINEVNGISRV 502
Query: 294 LYDITNKPPATIEFE 308
+YDI+ KPPATIE+E
Sbjct: 503 VYDISGKPPATIEWE 517
>pir||A82558 glutamine amidotransferase XF2429 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9107620|gb|AAF85228.1|AE004052_3
(AE004052) glutamine amidotransferase [Xylella
fastidiosa]
Length = 522
Score = 300 bits (759), Expect = 2e-80
Identities = 161/312 (51%), Positives = 217/312 (68%), Gaps = 10/312 (3%)
Query: 7 VEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFV 66
+E+++ +RE VG + I+ LSGGVDSS A L KAIG +L VFV+TG LR GE + V
Sbjct: 211 IEDQIAHVRERVGCDEVILGLSGGVDSSVVAALLQKAIGSQLTCVFVDTGLLRWGEGDQV 270
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVA-REIGAEYLI 125
+ F + G+N+ ++A R+F AL+GV DPE KRKIIG +FI++FEE A + A++L
Sbjct: 271 MAMFAEHMGVNVVRINAASRYFDALQGVYDPEAKRKIIGNLFIQIFEEEASKRKQAKWLA 330
Query: 126 QGTIAPDWIESQGK-------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGL 178
QGTI PD IES G IKSHHNVGGLPE++ L ++EPLR+L+KDEVR L LGL
Sbjct: 331 QGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEQMTLGMVEPLRELFKDEVRRLGVALGL 390
Query: 179 PEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVLLG 236
P + R PFPGPGL VR++GEV PE ++ +A+AI +E+ +A L + QAFAV L
Sbjct: 391 PHAMVYRHPFPGPGLGVRILGEVKPEYAELLAKADAIFIDELHQADLYDKVSQAFAVFLP 450
Query: 237 VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYD 296
VK+VGV GD RAY+ IA+R VE++D MTA +P++ L ++ RI +E+ V RV+YD
Sbjct: 451 VKSVGVVGDARAYEWVIALRAVETVDFMTAQWAPLPYDFLSTVSNRIINELRGVSRVVYD 510
Query: 297 ITNKPPATIEFE 308
I+ KPPATIE+E
Sbjct: 511 ISGKPPATIEWE 522
>emb|CAA49847.1| (X70397) GMP synthase [Saccharomyces cerevisiae]
Length = 525
Score = 299 bits (758), Expect = 2e-80
Identities = 164/324 (50%), Positives = 219/324 (66%), Gaps = 17/324 (5%)
Query: 2 NW--EKFVEEKVKEIRETVGDSKAII-ALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFL 58
NW E F++ ++ IR+ VG + +I A+SGGVDS+ A+ L +AIGD+ HA+ V+ G L
Sbjct: 202 NWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVL 261
Query: 59 RKGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVARE 118
R E V KT + G+NL VDA + F S LKGVTDPE+KRKIIG FI VFE A +
Sbjct: 262 RLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEK 321
Query: 119 IGA------EYLIQGTIAPDWIES------QGKIKSHHNVGGLPERLNLKLIEPLRDLYK 166
I ++L+QGT+ PD IES IK+HHNVGGL E + LKLIEPLR+L+K
Sbjct: 322 IKPRDGKEIQFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFK 381
Query: 167 DEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL- 225
DEVR L + LG+P + R PFPGPG+A+RV+GEVT E++ I R+A+ I EE+++AGL
Sbjct: 382 DEVRHLGELLGIPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLY 441
Query: 226 -RPWQAFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRIT 284
+ QAFA LL VK+VGV GD R Y + IA+R +E+ D MTA+ L+++A RI
Sbjct: 442 NQISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIV 501
Query: 285 SEIPEVGRVLYDITNKPPATIEFE 308
+E+ V RV YDIT+KPPAT+E+E
Sbjct: 502 NEVDGVARVTYDITSKPPATVEWE 525
>gi|6323873 GMP synthase; Gua1p [Saccharomyces cerevisiae]
>gi|1708073|sp|P38625|GUAA_YEAST GMP SYNTHASE
[GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|1077145|pir||S55099 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) [validated] - yeast
(Saccharomyces cerevisiae) >gi|854469|emb|CAA89932.1|
(Z49809) Gua1p [Saccharomyces cerevisiae]
Length = 525
Score = 299 bits (758), Expect = 2e-80
Identities = 164/324 (50%), Positives = 219/324 (66%), Gaps = 17/324 (5%)
Query: 2 NW--EKFVEEKVKEIRETVGDSKAII-ALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFL 58
NW E F++ ++ IR+ VG + +I A+SGGVDS+ A+ L +AIGD+ HA+ V+ G L
Sbjct: 202 NWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVL 261
Query: 59 RKGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVARE 118
R E V KT + G+NL VDA + F S LKGVTDPE+KRKIIG FI VFE A +
Sbjct: 262 RLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEK 321
Query: 119 IGA------EYLIQGTIAPDWIES------QGKIKSHHNVGGLPERLNLKLIEPLRDLYK 166
I ++L+QGT+ PD IES IK+HHNVGGL E + LKLIEPLR+L+K
Sbjct: 322 IKPKDGKEIQFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFK 381
Query: 167 DEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL- 225
DEVR L + LG+P + R PFPGPG+A+RV+GEVT E++ I R+A+ I EE+++AGL
Sbjct: 382 DEVRHLGELLGIPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLY 441
Query: 226 -RPWQAFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRIT 284
+ QAFA LL VK+VGV GD R Y + IA+R +E+ D MTA+ L+++A RI
Sbjct: 442 NQISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIV 501
Query: 285 SEIPEVGRVLYDITNKPPATIEFE 308
+E+ V RV YDIT+KPPAT+E+E
Sbjct: 502 NEVDGVARVTYDITSKPPATVEWE 525
>sp|P46810|GUAA_MYCLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|2145847|pir||S72813 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) - Mycobacterium
leprae >gi|466934|gb|AAC43222.1| (U00015) guaA;
B1620_C2_205 [Mycobacterium leprae]
Length = 590
Score = 295 bits (747), Expect = 5e-79
Identities = 163/314 (51%), Positives = 210/314 (65%), Gaps = 16/314 (5%)
Query: 11 VKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFVVKTF 70
V+++R +G+ AI LSGGVDS+ AA L +AIGD+L +FV+ G LR GE V + F
Sbjct: 277 VEQVRAQIGNGHAICGLSGGVDSAVAAALVQRAIGDRLTCIFVDHGLLRDGERGQVQRDF 336
Query: 71 RDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI--------GAE 122
G L VDA + F AL GVT+PE KRKIIGR FI FE R++ G E
Sbjct: 337 VAATGAKLVTVDAAETFLQALSGVTNPEGKRKIIGRQFIRAFEGAVRDLLGDSTFDSGIE 396
Query: 123 YLIQGTIAPDWIESQG-----KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLG 177
+L+QGT+ PD +ES G IKSHHNVGGLP+ L KL+EPLR L+KDEVR + + L
Sbjct: 397 FLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDNLRFKLVEPLRLLFKDEVRAVGRQLD 456
Query: 178 LPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVLL 235
LPE+I R PFPGPGL +R++GEVT E++ +R A++I EE+ AGL + WQ VLL
Sbjct: 457 LPEEIVARQPFPGPGLGIRIVGEVTAERLDTLRRADSIAREELTTAGLDYQIWQCPVVLL 516
Query: 236 G-VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVL 294
V++VGVQGD R+Y I +R V S D MTA+ VP+EVL+ I+ RIT+E+ EV RV+
Sbjct: 517 ADVRSVGVQGDNRSYGHPIVLRPVSSEDAMTADWTWVPYEVLECISTRITNEVAEVNRVV 576
Query: 295 YDITNKPPATIEFE 308
DITNKPP TIE+E
Sbjct: 577 LDITNKPPGTIEWE 590
>pir||G81971 probable GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) NMA0534
[imported] - Neisseria meningitidis (group A strain
Z2491) >gi|7379274|emb|CAB83828.1| (AL162753) putative
GMP synthetase [Neisseria meningitidis Z2491]
Length = 521
Score = 293 bits (741), Expect = 2e-78
Identities = 160/319 (50%), Positives = 214/319 (66%), Gaps = 16/319 (5%)
Query: 6 FVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEF 65
++EE V +IRE VG + I+ LSGGVDSS AA L ++AIGD+L VFV+ G LR E +
Sbjct: 203 YIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKM 262
Query: 66 VVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAEYL 124
V+ F G+ + +VDA+ +F + L GVTDPE+KRKIIG FIEVF+ +++ A++L
Sbjct: 263 VMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKIIGAEFIEVFDAEEKKLTNAKWL 322
Query: 125 IQGTIAPDWIESQG-------KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLG 177
QGTI PD IES G IKSHHNVGGLPE + LKL+EPLRDL+KDEVREL LG
Sbjct: 323 AQGTIYPDVIESAGAKTKKAHAIKSHHNVGGLPENMKLKLLEPLRDLFKDEVRELGVALG 382
Query: 178 LPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERA---GLRPW-----Q 229
LP ++ R PFPGPGL VR++GEV E ++R+A+ I +E+ W Q
Sbjct: 383 LPREMVYRHPFPGPGLGVRILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQ 442
Query: 230 AFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPE 289
AFAV L VK+VGV GD R Y +A+R V + D MTA+ +P+ +L R++ RI +E+
Sbjct: 443 AFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAHWAELPYSLLGRVSNRIINEVKG 502
Query: 290 VGRVLYDITNKPPATIEFE 308
+ RV+YD++ KPPATIE+E
Sbjct: 503 INRVVYDVSGKPPATIEWE 521
>pir||D81026 GMP synthase NMB1920 [imported] - Neisseria meningitidis (group B
strain MD58) >gi|7227178|gb|AAF42250.1| (AE002541) GMP
synthase [Neisseria meningitidis MC58]
Length = 521
Score = 292 bits (740), Expect = 3e-78
Identities = 160/319 (50%), Positives = 214/319 (66%), Gaps = 16/319 (5%)
Query: 6 FVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEF 65
++EE V +IRE VG + I+ LSGGVDSS AA L ++AIGD+L VFV+ G LR E +
Sbjct: 203 YIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNESKM 262
Query: 66 VVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAEYL 124
V+ F G+ + +VDA+ +F + L GVTDPE+KRKIIG FIEVF+ +++ A++L
Sbjct: 263 VMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKIIGAEFIEVFDAEEKKLTNAKWL 322
Query: 125 IQGTIAPDWIESQG-------KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLG 177
QGTI PD IES G IKSHHNVGGLPE + LKL+EPLRDL+KDEVREL LG
Sbjct: 323 AQGTIYPDVIESAGAKTKKAHAIKSHHNVGGLPENMKLKLLEPLRDLFKDEVRELGVALG 382
Query: 178 LPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERA---GLRPW-----Q 229
LP ++ R PFPGPGL VR++GEV E ++R+A+ I +E+ W Q
Sbjct: 383 LPREMVYRHPFPGPGLGVRILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQ 442
Query: 230 AFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPE 289
AFAV L VK+VGV GD R Y IA+R V + D MTA+ +P+ +L +++ RI +E+
Sbjct: 443 AFAVFLPVKSVGVMGDGRTYDYVIALRAVITSDFMTAHWAELPYSLLGKVSNRIINEVKG 502
Query: 290 VGRVLYDITNKPPATIEFE 308
+ RV+YD++ KPPATIE+E
Sbjct: 503 INRVVYDVSGKPPATIEWE 521
>gb|AAF09154.1|AC011622_11 (AC011622) GMP synthase; 61700-64653 [Arabidopsis thaliana]
Length = 534
Score = 287 bits (728), Expect = 8e-77
Identities = 159/325 (48%), Positives = 213/325 (64%), Gaps = 20/325 (6%)
Query: 4 EKFVEEKVKEIRETVG-DSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGE 62
E +EE++K I +TV D I ALSGGVDS+ AA L +KAIGD+LH +FV+ G LR E
Sbjct: 210 EDLMEEEIKVINKTVASDEHVICALSGGVDSTVAATLVHKAIGDRLHCIFVDNGLLRYKE 269
Query: 63 PEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAE 122
E V+ TF + + + VDA +RF S LKGV DPE KRKIIGR FI +F++ A+E+ +
Sbjct: 270 QERVMDTFERDLHLPVTCVDASERFLSELKGVVDPETKRKIIGREFINIFDQFAQELEKK 329
Query: 123 ------YLIQGTIAPDWIES----------QGKIKSHHNVGGLPERLNLKLIEPLRDLYK 166
+L+QGT+ PD IES IKSHHNVGGLP+ + LKLIEPL+ L+K
Sbjct: 330 HGKKPAFLVQGTLYPDVIESCPPPGTDRTHSHTIKSHHNVGGLPKDMKLKLIEPLKLLFK 389
Query: 167 DEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTP-EKIRIVREANAIVEEEVERAGL 225
DEVREL + L +P R PFPGPGLAVRV+G+VT + ++R+ + I + + AGL
Sbjct: 390 DEVRELGRILNVPVGFLKRHPFPGPGLAVRVLGDVTQGNALEVLRQVDEIFIQSIRDAGL 449
Query: 226 RP--WQAFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRI 283
WQAFAV L V++VGVQGD R + +A+R V S DGMTA+ N + L ++ +I
Sbjct: 450 YDSIWQAFAVFLPVRSVGVQGDKRTHSHVVALRAVTSQDGMTADWFNFEHKFLDDVSRKI 509
Query: 284 TSEIPEVGRVLYDITNKPPATIEFE 308
+ + V RV+ DIT+KPP+TIE+E
Sbjct: 510 CNSVQGVNRVVLDITSKPPSTIEWE 534
>pir||F71865 gmp synthetase - Helicobacter pylori (strain J99)
>gi|4155553|gb|AAD06548.1| (AE001526) GMP SYNTHETASE
[Helicobacter pylori J99]
Length = 508
Score = 286 bits (725), Expect = 2e-76
Identities = 154/317 (48%), Positives = 217/317 (67%), Gaps = 13/317 (4%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
+ F + ++ ++E + ++K + A+SGGVDS+ A L ++AI D L AVFV+ G LRK E
Sbjct: 193 QHFAQREIVRLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAVFVDHGLLRKNEK 252
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGA-- 121
E V F+D + L+ +DA++ F S LKGV++PE KRKIIG FIEVFE+ A++
Sbjct: 253 EKVQAMFKD-LQIPLNTIDAKEVFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKG 311
Query: 122 --EYLIQGTIAPDWIESQGK------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELA 173
E+L QGT+ PD IES IK+HHNVGGLPE ++ KLIEPLR+L+KDEVR L
Sbjct: 312 KIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEVRLLG 371
Query: 174 KFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAF 231
K LG+ + R PFPGPGLA+R++GE+ KI+ ++EA+AI EE+++A L + WQAF
Sbjct: 372 KELGVSQDFLMRHPFPGPGLAIRILGEINENKIKRLQEADAIFIEELKKANLYDKVWQAF 431
Query: 232 AVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVG 291
VLL V +VGV GD R Y+ I +R V + DGMTA+ + L++++ RIT+E+ +
Sbjct: 432 CVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVSNRITNEVNGIN 491
Query: 292 RVLYDITNKPPATIEFE 308
RV+YDIT+KPP TIE+E
Sbjct: 492 RVVYDITSKPPGTIEWE 508
>sp|O25165|GUAA_HELPY GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|7438054|pir||A64571 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) - Helicobacter
pylori (strain 26695) >gi|2313515|gb|AAD07477.1|
(AE000557) GMP synthase (guaA) [Helicobacter pylori
26695]
Length = 508
Score = 286 bits (723), Expect = 3e-76
Identities = 154/317 (48%), Positives = 217/317 (67%), Gaps = 13/317 (4%)
Query: 4 EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEP 63
+ F + ++ ++E + ++K + A+SGGVDS+ A L ++AI D L AVFV+ G LRK E
Sbjct: 193 QHFAQREIARLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAVFVDHGLLRKNEK 252
Query: 64 EFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGA-- 121
E V F+D + L+ +DA++ F S LKGV++PE KRKIIG FIEVFE+ A++
Sbjct: 253 ERVQAMFKD-LKIPLNTIDAKEVFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKG 311
Query: 122 --EYLIQGTIAPDWIESQGK------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELA 173
E+L QGT+ PD IES IK+HHNVGGLPE ++ KLIEPLR+L+KDEVR L
Sbjct: 312 KIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEVRLLG 371
Query: 174 KFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAF 231
K LG+ + R PFPGPGLAVR++GE++ KI+ ++EA+ I EE+++A L + WQAF
Sbjct: 372 KELGVSQDFLMRHPFPGPGLAVRILGEISESKIKRLQEADFIFIEELKKANLYDKVWQAF 431
Query: 232 AVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVG 291
VLL V +VGV GD R Y+ I +R V + DGMTA+ + L++++ RIT+E+ +
Sbjct: 432 CVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVSNRITNEVSGIN 491
Query: 292 RVLYDITNKPPATIEFE 308
RV+YDIT+KPP TIE+E
Sbjct: 492 RVVYDITSKPPGTIEWE 508
>pir||G83173 GMP synthase PA3769 [imported] - Pseudomonas aeruginosa (strain
PAO1) >gi|9949940|gb|AAG07156.1|AE004796_1 (AE004796)
GMP synthase [Pseudomonas aeruginosa]
Length = 525
Score = 285 bits (722), Expect = 4e-76
Identities = 153/312 (49%), Positives = 210/312 (67%), Gaps = 10/312 (3%)
Query: 7 VEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFV 66
V++ + +R VG SK ++ LSGGVDSS A L +KAIGD+L VFV+ G LR E + V
Sbjct: 214 VDDAIATVRAQVGSSKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQV 273
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAEYLI 125
+ F + G+ + +A+D+F L GV DPEEKRKIIGR FIEVF+E A ++ ++L
Sbjct: 274 MAMFAENMGVKVIRANAEDKFLGRLAGVADPEEKRKIIGRTFIEVFDEEATKLQDVKFLA 333
Query: 126 QGTIAPDWIESQGK-------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGL 178
QGTI PD IES G IKSHHNVGGLPE + +L+EPLR+L+KDEVR++ LGL
Sbjct: 334 QGTIYPDVIESAGAKTGKAHVIKSHHNVGGLPEDMQFELVEPLRELFKDEVRKIGLELGL 393
Query: 179 PEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVLLG 236
P + R PFPGPGL VR++GEV E ++R+A+ I EE+ + QAF V
Sbjct: 394 PYDMVYRHPFPGPGLGVRILGEVKKEYADLLRQADHIFIEELRAFDWYHKTSQAFVVFQP 453
Query: 237 VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYD 296
VK+VGV GD R Y +A+R VE++D MTA ++P+E+L++++ RI +EI + RV YD
Sbjct: 454 VKSVGVVGDGRRYAWVVALRAVETIDFMTARWAHLPYELLEKVSNRIINEIAGISRVTYD 513
Query: 297 ITNKPPATIEFE 308
+++KPPATIE+E
Sbjct: 514 VSSKPPATIEWE 525
>pir||B75342 GMP synthase - Deinococcus radiodurans (strain R1)
>gi|6459656|gb|AAF11428.1|AE002027_1 (AE002027) GMP
synthase [Deinococcus radiodurans]
Length = 506
Score = 284 bits (720), Expect = 7e-76
Identities = 157/316 (49%), Positives = 211/316 (66%), Gaps = 10/316 (3%)
Query: 2 NWEKFVEEKVKEIRETVGDS-KAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRK 60
N E V+E ++ +R VGD+ + ++ +SGGVDSST A+L KA+G++L AVF++ G LR
Sbjct: 192 NAEHIVDELIEGVRAQVGDTGRVLLGISGGVDSSTLALLLAKAVGERLTAVFIDHGLLRL 251
Query: 61 GEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIG 120
GE E V+ G+NL VDA+D F L GV+DPE+KRKIIGR FI FE ++G
Sbjct: 252 GERE-QVEAALTPLGVNLVTVDAKDEFLGQLAGVSDPEQKRKIIGREFIRAFERETAKLG 310
Query: 121 A-EYLIQGTIAPDWIESQG-----KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAK 174
E+L QGT+ PD IES G IKSHHNVGGLP+ + KL+EP R L+KDEVRE+A+
Sbjct: 311 DFEFLAQGTLYPDVIESAGGEGAANIKSHHNVGGLPDDVQFKLVEPFRTLFKDEVREIAR 370
Query: 175 FLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPW--QAFA 232
LGLP+ I R PFPGPGLA+R +GEVT EK+ I++ + I + GL QA A
Sbjct: 371 LLGLPDHIRMRHPFPGPGLAIRCLGEVTAEKVDILQRVDDIFISGLREFGLYDGCSQALA 430
Query: 233 VLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGR 292
VL +++VGV GD R Y T A+R V + D MTA +P++ L ++ RI +++ E+ R
Sbjct: 431 VLTPIQSVGVMGDERTYSYTAALRAVTTDDFMTAEWARLPYDFLATMSNRIVNQVHEINR 490
Query: 293 VLYDITNKPPATIEFE 308
V+YDIT KPPATIE+E
Sbjct: 491 VVYDITGKPPATIEWE 506
>gi|11497008 GMP synthase (guaA) [Borrelia burgdorferi]
>gi|3915728|sp|P49056|GUAA_BORBU GMP SYNTHASE
[GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|7438056|pir||F70218 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) guaA - Lyme disease
spirochete plasmid B/cp26 >gi|2689885|gb|AAC66313.1|
(AE000792) GMP synthase (guaA) [Borrelia burgdorferi]
Length = 528
Score = 284 bits (718), Expect = 1e-75
Identities = 152/319 (47%), Positives = 217/319 (67%), Gaps = 12/319 (3%)
Query: 1 MNW--EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFL 58
+NW E +E VK+I+ VG K I+ LSGG DS A+L KAI + L VFVNTG L
Sbjct: 211 INWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLL 270
Query: 59 RKGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVARE 118
RK E + +++ + ++ +N+ Y+DA +F + LK ++DPEEKRKIIG+ F++VFE++ E
Sbjct: 271 RKNEDKKILE-LKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLE 329
Query: 119 I-GAEYLIQGTIAPDWIESQGK------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRE 171
EYL QGTI D IES+ K IKSHHNVGGLP++++LKL+EPL + +KDE+ +
Sbjct: 330 DQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQ 389
Query: 172 LAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEE--VERAGLRPWQ 229
+ LG+ ++ R PFPGPGLA+R+IGEVT EKI I++EA+ I+ EE + + Q
Sbjct: 390 IGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQ 449
Query: 230 AFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPE 289
AF VLL VK+VGV GD R Y+ T +R V + D MTA +P+ L++++ RI +E+
Sbjct: 450 AFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRG 509
Query: 290 VGRVLYDITNKPPATIEFE 308
+ RV YDI++KPP+TIE+E
Sbjct: 510 INRVCYDISSKPPSTIEWE 528
>pir||I40246 GMP synthetase - Lyme disease spirochete >gi|495734|gb|AAA53232.1|
(L25883) GMP synthetase [Borrelia burgdorferi]
Length = 512
Score = 283 bits (717), Expect = 2e-75
Identities = 152/319 (47%), Positives = 217/319 (67%), Gaps = 12/319 (3%)
Query: 1 MNW--EKFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFL 58
+NW E +E VK+I+ VG K I+ LSGG DS A+L KAI + L VFVNTG L
Sbjct: 195 INWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLL 254
Query: 59 RKGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVARE 118
RK E + +++ + ++ +N+ Y+DA +F + LK ++DPEEKRKIIG+ F++VFE++ E
Sbjct: 255 RKNENKKILE-LKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLE 313
Query: 119 I-GAEYLIQGTIAPDWIESQGK------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRE 171
EYL QGTI D IES+ K IKSHHNVGGLP++++LKL+EPL + +KDE+ +
Sbjct: 314 DQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQ 373
Query: 172 LAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEE--VERAGLRPWQ 229
+ LG+ ++ R PFPGPGLA+R+IGEVT EKI I++EA+ I+ EE + + Q
Sbjct: 374 IGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQ 433
Query: 230 AFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPE 289
AF VLL VK+VGV GD R Y+ T +R V + D MTA +P+ L++++ RI +E+
Sbjct: 434 AFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRG 493
Query: 290 VGRVLYDITNKPPATIEFE 308
+ RV YDI++KPP+TIE+E
Sbjct: 494 INRVCYDISSKPPSTIEWE 512
>gb|AAD24213.1| (AF086638) unknown [Pseudomonas putida GB-1]
Length = 436
Score = 280 bits (709), Expect = 1e-74
Identities = 149/312 (47%), Positives = 210/312 (66%), Gaps = 10/312 (3%)
Query: 7 VEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFV 66
VE+ + ++R VG + ++ LSGGVDSS A L ++AIGD+L VFV+ G LR E + V
Sbjct: 125 VEDAIAQVRAQVGSANVLLGLSGGVDSSVVAALLHRAIGDQLTCVFVDNGLLRLHEGDQV 184
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREI-GAEYLI 125
+ F++ G+ + DA+ +F L+G DPE+KRKIIGR FI++F+ A ++ ++L
Sbjct: 185 MAMFKENMGVKVIRADAEKQFLDNLEGEADPEKKRKIIGRTFIDIFDAEASKLENIQFLA 244
Query: 126 QGTIAPDWIESQGK-------IKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGL 178
QGTI PD IES G IKSHHNVGGLPE +NLKL+EPLR+L+KDEVR++ LGL
Sbjct: 245 QGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRKIGLELGL 304
Query: 179 PEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVLLG 236
P + R PFPGPGL VR++GEV E I+R A+ I +E+ +A + QAF V
Sbjct: 305 PYDMVYRHPFPGPGLGVRILGEVKKEYADILRRADHIFIKELRKADWYHKTSQAFVVFQP 364
Query: 237 VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYD 296
VK+VGV GD R Y +A+R E++D MTA ++P+E+L+ ++ RI +EI + RV YD
Sbjct: 365 VKSVGVVGDGRRYTWVVALRAHETVDFMTARWAHLPYELLETVSGRIINEIDGISRVTYD 424
Query: 297 ITNKPPATIEFE 308
+++KPPATIE+E
Sbjct: 425 VSSKPPATIEWE 436
>dbj|BAA89456.1| (AB003155) GMP synthetase [Corynebacterium ammoniagenes]
Length = 524
Score = 280 bits (708), Expect = 2e-74
Identities = 157/318 (49%), Positives = 206/318 (64%), Gaps = 17/318 (5%)
Query: 8 EEKVKEIRETVG-DSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFV 66
++ + ++R +G + +AI LSGGVDS+ AA L +AIGD+L VFV+ G LR GE E V
Sbjct: 207 QQLIDDVRAQIGPEGRAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGEREQV 266
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFE--------EVARE 118
K F G L D F S L GVTDPE KRK IG FI FE E +
Sbjct: 267 EKDFVASTGAKLITAHEADAFLSKLAGVTDPEAKRKAIGAEFIRSFERAVAQALEESPED 326
Query: 119 IGAEYLIQGTIAPDWIESQG-----KIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELA 173
++L+QGT+ PD +ES G IKSHHNVGGLP+ + +L+EPLR L+KDEVR +
Sbjct: 327 STVDFLVQGTLYPDVVESGGGDGTANIKSHHNVGGLPDDVEFELVEPLRLLFKDEVRAVG 386
Query: 174 KFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAF 231
+ LGLPE+I R PFPGPGL +R+IGEVT E++ I+R+A+ I E+ AGL WQ
Sbjct: 387 RELGLPEEIVARQPFPGPGLGIRIIGEVTEERLEILRQADLIARTELTNAGLDGDIWQCP 446
Query: 232 AVLLG-VKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEV 290
VLL V++VGVQGD R Y I +R V S D MTA+ VP++VL++I+ RIT+E+ +V
Sbjct: 447 VVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYDVLEKISTRITNEVNDV 506
Query: 291 GRVLYDITNKPPATIEFE 308
RV+ DIT+KPP TIE+E
Sbjct: 507 NRVVVDITSKPPGTIEWE 524
>emb|CAB88269.1| (AL353014) GMP synthase [glutamine-hydrolyzing]
[Schizosaccharomyces pombe]
Length = 539
Score = 271 bits (685), Expect = 9e-72
Identities = 153/325 (47%), Positives = 208/325 (63%), Gaps = 18/325 (5%)
Query: 2 NW--EKFVEEKVKEIRETVGDSKAII-ALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFL 58
NW E FV++++ IR+ +G S +I A+SGGVDS+ A+ + +AIGD+ HA+ V+ G L
Sbjct: 215 NWSMENFVDKEILRIRKMIGPSDHVIGAVSGGVDSTVASKVLKEAIGDRFHAIMVDNGLL 274
Query: 59 RKGEPEFVVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVARE 118
R E E V +T G+ L VDA + F LKGVTDPE+KRKIIG FI VFE A
Sbjct: 275 RLNEAEIVRETLNKHLGIQLTVVDASEEFIGKLKGVTDPEKKRKIIGNTFIHVFEREAER 334
Query: 119 I------GAEYLIQGTIAPDWIES------QGKIKSHHNVGGLPERLNLKLIEPLRDLYK 166
I EYL+QGT+ PD IES IK+HHNVGGL + + LKLIEPLR+L+K
Sbjct: 335 IVKETNGKVEYLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLKDMKLKLIEPLRELFK 394
Query: 167 DEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL- 225
DEVR L + LG+ + R PFPGPGL +R++GEV ++ I R+A+ I E+ G
Sbjct: 395 DEVRALGELLGIEHSLVWRHPFPGPGLGIRILGEVNAAQLEIARKADHIFITEIRNHGYY 454
Query: 226 -RPWQAFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMN-VPWEVLQRIAFRI 283
+ QAFA LL VK VGV GD R +++ IA+R + + D MTA+ + + L+ ++ RI
Sbjct: 455 DKISQAFAALLPVKAVGVMGDKRTHEQVIALRAITTSDFMTADWYDGFSIKFLKLVSSRI 514
Query: 284 TSEIPEVGRVLYDITNKPPATIEFE 308
+E+ V RVLYDI++KPPAT+E E
Sbjct: 515 CNEVSGVNRVLYDISSKPPATVEME 539
>gb|AAK43326.1| GMP synthase, PP-ATPase domain (guaA) [Sulfolobus solfataricus]
Length = 367
Score = 252 bits (637), Expect = 4e-66
Identities = 147/362 (40%), Positives = 204/362 (55%), Gaps = 60/362 (16%)
Query: 6 FVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEF 65
FVEE ++R+ +G+ K + A+SGGVDS+TAAVLAY +GDK+ V V+TGFLRK E E
Sbjct: 7 FVEEIGPQLRQKLGNEKVLAAVSGGVDSTTAAVLAYNLLGDKVIPVLVDTGFLRKNEAE- 65
Query: 66 VVKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAEYLI 125
+K + NL VD ++ F S ++G+ D E KRK +F + ++ A YL+
Sbjct: 66 KIKDYLSNILPNLIIVDKKETFISEIEGIDDAEMKRKRFRELFYSTISSLMKKFNARYLM 125
Query: 126 QGTIAPDWIESQGKIKSHHNVG-----GLPERLNLKLIEPLRDLYKDEVRELAKFLGLPE 180
QGTIA DW+E+QG IK+ HNV + LIEPL DLYK+EVRELA++L LP+
Sbjct: 126 QGTIAADWVETQGGIKTQHNVLVQIGIDTEKEWGFTLIEPLADLYKNEVRELARYLKLPK 185
Query: 181 KIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRPWQAF--------- 231
+I R PFPGPGL VR +G++T EK+ +VREAN IVE+ ++ + A
Sbjct: 186 EISERQPFPGPGLLVRAVGKLTREKLEVVREANDIVEKYLDPFNYSQYFAVSFESYGNLV 245
Query: 232 ------AVLLGVKTVGVQGDIRAY------------------------------------ 249
A L + GV+GD+RAY
Sbjct: 246 NLDGIDAFLYKARATGVKGDVRAYGNIAKIECSNINNVKNIIDTLVKYDITHVLCTLDER 305
Query: 250 ---KETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPPATIE 306
K ++A+R V + D MTA+ + +P E+L +I+ I +IP V VLYD+T+KPPATIE
Sbjct: 306 NSGKYSVAIRAVTTEDFMTADYVRIPKEILSKISSEILQKIPNVKEVLYDVTSKPPATIE 365
Query: 307 FE 308
FE
Sbjct: 366 FE 367
>gb|AAF09184.1|AF152349_1 (AF152349) GMP synthetase [Plasmodium falciparum]
Length = 555
Score = 249 bits (630), Expect = 2e-65
Identities = 137/317 (43%), Positives = 200/317 (62%), Gaps = 13/317 (4%)
Query: 5 KFVEEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPE 64
++ E ++K I + D I A+SGG+DS+ AA +K ++ +F++ G LRK E E
Sbjct: 239 RYHELELKNIEKYKHDHYVIAAMSGGIDSTVAAAYTHKIFKERFFGIFIDNGLLRKNEAE 298
Query: 65 FVVKTFRDEF-GMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAEY 123
V + F MN+ +DA + F S L+GVTDP K++ ++ + + I EY
Sbjct: 299 NVYTFLKSTFPDMNITKIDASENFLSNLQGVTDPRTKKENYRGNYLLKNLKRRKYIDIEY 358
Query: 124 ----LIQGTIAPDWIESQ------GKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELA 173
L+QGT+ PD IES+ IK+HHNVGGLP+ L KL EP + L+KD+V+ L+
Sbjct: 359 KQTFLLQGTLYPDIIESKCSKNLSDTIKTHHNVGGLPKNLKFKLFEPFKYLFKDDVKTLS 418
Query: 174 KFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAF 231
+ L LPE+I NR PFPGPGLA+RVIGE+ K+ I+RE + I ++++ GL + QAF
Sbjct: 419 RELNLPEEITNRHPFPGPGLAIRVIGEINKHKLNILREVDDIFINDLKQYGLYNQISQAF 478
Query: 232 AVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVG 291
AVLL K+VGV+GD R+Y +R V++ MTAN +P+++L +I RI SE+ V
Sbjct: 479 AVLLSSKSVGVRGDARSYDYVCVLRAVKTSSFMTANWYQIPYDILDKITTRILSEVKGVN 538
Query: 292 RVLYDITNKPPATIEFE 308
R+LYD+++KPPATIEFE
Sbjct: 539 RILYDVSSKPPATIEFE 555
>sp|O52831|GUAA_CORAM GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|2765079|emb|CAA71524.1| (Y10499)
GMP synthase [Corynebacterium ammoniagenes]
Length = 522
Score = 240 bits (605), Expect = 2e-62
Identities = 140/317 (44%), Positives = 191/317 (60%), Gaps = 17/317 (5%)
Query: 8 EEKVKEIRETVG-DSKAIIALSGGVDSSTAAVLAYKAIGDKLHAVFVNTGFLRKGEPEFV 66
++ + ++R +G + +AI LSGGVDS+ AA L +AIGD+L VFV+ G LR GE E V
Sbjct: 207 QQLIDDVRAQIGPEGRAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGEREQV 266
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVTDPEEKRKIIGRVFIEVF--------EEVARE 118
K F G N+ D F S L GVTDPE KRK IG FI F EE +
Sbjct: 267 EKDFVASTGANVITAHEADAFLSKLAGVTDPEAKRKAIGAEFIRSFERAVAQALEESPED 326
Query: 119 IGAEYLIQGTIAPDWIES-----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELA 173
++L+QGT+ PD +ES IKSHHNVGGLP+ + +L+EPLR L + +
Sbjct: 327 STVDFLVQGTLYPDVVESGRGDGTANIKSHHNVGGLPDDVEFELVEPLRLLLRRSPCR-S 385
Query: 174 KFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVERAGLRP--WQAF 231
+ LGLPE+I R PFPGPGL +R+IGEVT E++ I+R+A+ I E+ AGL WQ
Sbjct: 386 RELGLPEEIVARQPFPGPGLGIRIIGEVTEERLEILRQADLIARTELTNAGLDGDIWQCQ 445
Query: 232 AVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVG 291
+ L + + I +R V S D MTA+ VP++VL++I+ RIT+E+ +V
Sbjct: 446 SYCLPMSAPSSPRRRPHLRHPIVLRPVSSEDAMTADWTRVPYDVLEKISTRITNEVNDVN 505
Query: 292 RVLYDITNKPPATIEFE 308
RV+ DIT+KPP TIE+E
Sbjct: 506 RVVVDITSKPPGTIEWE 522
>pir||B72109 GMP synthase CP0599 [imported] - Chlamydophila pneumoniae (strains
CWL029 and AR39) >gi|4376440|gb|AAD18324.1| (AE001604)
GMP Synthase [Chlamydophila pneumoniae CWL029]
>gi|7189511|gb|AAF38415.1| (AE002218) GMP synthase
[Chlamydophila pneumoniae AR39]
>gi|8978544|dbj|BAA98381.1| (AP002545) GMP synthase
[Chlamydophila pneumoniae J138]
Length = 429
Score = 207 bits (521), Expect = 1e-52
Identities = 113/208 (54%), Positives = 146/208 (69%), Gaps = 8/208 (3%)
Query: 109 IEVFEEVAREIGAEYLIQGTIAPDWIESQGK------IKSHHNVGGLPERLNLKLIEPLR 162
IEVF+EVA+ + ++L QGTI D IES IKSHHNVGGLP+ L LKL+EPLR
Sbjct: 222 IEVFDEVAQSLDVQWLAQGTIYSDVIESSRSGHASEVIKSHHNVGGLPKNLKLKLVEPLR 281
Query: 163 DLYKDEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEVER 222
L+KDEVR L + LGL + +R PFPGPGL +RVIGE+ PE + I+R A+ I EE+ +
Sbjct: 282 YLFKDEVRILGEALGLSSYLLDRHPFPGPGLTIRVIGEILPEYLAILRRADLIFIEELRK 341
Query: 223 AGL--RPWQAFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIA 280
A L + QAFA+ L +K+V V+GD R+Y TIA+R VES D MT +P +VL +
Sbjct: 342 AKLYDKISQAFALFLPIKSVSVKGDCRSYGYTIALRAVESTDFMTGRWAYLPCDVLSSCS 401
Query: 281 FRITSEIPEVGRVLYDITNKPPATIEFE 308
RI +EIPEV RV+YDI++KPPATIE+E
Sbjct: 402 SRIINEIPEVSRVVYDISDKPPATIEWE 429
>gb|AAB02826.1| (U59112) ORFB; putative GMP synthase like-protein [Dichelobacter
nodosus]
Length = 240
Score = 195 bits (490), Expect = 6e-49
Identities = 114/239 (47%), Positives = 156/239 (64%), Gaps = 12/239 (5%)
Query: 81 VDAQDRFFSALKGVTDPEEKR-KIIGRVFIEVF-EEVAREIGAEYLIQGTIAPDWIES-- 136
V+A DRF K VTDPEEK K+ GR+FIE+F EE A+++ G PD IES
Sbjct: 3 VNAADRFLHN-KRVTDPEEKTPKLSGRLFIEIFDEESAQKLRTLNGGAGHDYPDVIESLV 61
Query: 137 -----QGKIKSHHNVGGLPERLNLKLIEPLRDLYKDEVRELAKFLGLPEKIYNRMPFPGP 191
IKSHHNVGGLPE++NL L+EPLR L+KDEVR+L L LP+ + R PFPGP
Sbjct: 62 VKTAKAQVIKSHHNVGGLPEKMNLSLLEPLRMLFKDEVRQLGLALSLPQTMIYRHPFPGP 121
Query: 192 GLAVRVIGEVTPEKIRIVREANAIVEEEVERAGL--RPWQAFAVLLGVKTVGVQGDIRAY 249
GL VR++GEV E ++R+A+AI + + L QAFAV L +++VGV GD R Y
Sbjct: 122 GLGVRILGEVKAEYADLLRQADAIFIQALREYDLYDAVSQAFAVFLPIRSVGVMGDGRRY 181
Query: 250 KETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPPATIEFE 308
+A+R VE++D MTA +P++ L ++ RI + + + RV+YD+++KPPATIE+E
Sbjct: 182 DFVVALRAVETIDFMTARWAKLPYDFLDEVSRRIINHVSGISRVVYDVSSKPPATIEWE 240
>gi|4504035 guanine monophosphate synthetase; guanosine 5'-monophosphate
synthase; GMP Synthase; glutamine amidotransferase.
[Homo sapiens] >gi|1708072|sp|P49915|GUAA_HUMAN GMP
SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE
AMIDOTRANSFERASE) (GMP SYNTHETASE)
>gi|627453|pir||A54847 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) - human
>gi|595410|gb|AAA60331.1| (U10860) guanosine
5'-monophosphate synthetase [Homo sapiens]
Length = 693
Score = 158 bits (396), Expect = 7e-38
Identities = 122/351 (34%), Positives = 173/351 (48%), Gaps = 77/351 (21%)
Query: 9 EKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIG-DKLHAVFVNTGFLRKGEPEFVV 67
E ++EI+E VG SK ++ LSGGVDS+ L +A+ +++ AV ++ GF+RK E + V
Sbjct: 225 ECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVE 284
Query: 68 KTFRDEFGMNLHYVDAQDRFFSA--------------------LKGVTDPEEKRKIIGRV 107
+ + + G+ + ++A F++ L T PEEKRKIIG
Sbjct: 285 EALK-KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDT 343
Query: 108 FIEVFEEVAREIGAE----YLIQGTIAPDWIES-----QGK---IKSHHNVGGLPERLNL 155
F+++ EV E+ + +L QGT+ PD IES GK IK+HHN L +L
Sbjct: 344 FVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLRE 403
Query: 156 --KLIEPLRDLYKDEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREAN 213
K+IEPL+D +KDEVR L + LGLPE++ +R PFPGPGLA+RVI P + E N
Sbjct: 404 EGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETN 463
Query: 214 AIV-------------------------EEEVER----AGLRPWQAFAVLLGVKTVGVQG 244
I+ EE+ E+ L AF LL +KTVGVQG
Sbjct: 464 NILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAF--LLPIKTVGVQG 521
Query: 245 DIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLY 295
D R+Y + + D WE L +A I V RV+Y
Sbjct: 522 DCRSYSYVCGISSKDEPD----------WESLIFLARLIPRMCHNVNRVVY 562
>sp|P32073|GUAA_DICDI GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE)
(GMP SYNTHETASE) >gi|84114|pir||A41164 GMP synthase
(glutamine-hydrolyzing) (EC 6.3.5.2) - slime mold
(Dictyostelium discoideum) >gi|167807|gb|AAA33213.1|
(M64282) GMP synthetase [Dictyostelium discoideum]
Length = 718
Score = 155 bits (389), Expect = 4e-37
Identities = 113/341 (33%), Positives = 172/341 (50%), Gaps = 64/341 (18%)
Query: 8 EEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIG-DKLHAVFVNTGFLRKGEPEFV 66
++ + I+ V + K ++ +SGGVDS+ A L KAIG + + A+ ++ GF+RK E V
Sbjct: 255 QQAITYIKSIVSNKKVLVLVSGGVDSTVCAALISKAIGPENVIALHIDNGFMRKDESLNV 314
Query: 67 VKTFRDEFGMNLHYVDAQDRFF-----------SALKGVTDPEEKRKIIGRVFIEVFEEV 115
K G++L VDA F+ S+LK PEE+RKIIG F+ V E
Sbjct: 315 EKAL-SVLGLHLIVVDASQTFYNSTTTIKGHLTSSLKETISPEERRKIIGDTFMRVAENE 373
Query: 116 AREIGAE----YLIQGTIAPDWIESQGK--------IKSHHNVGGLPERL--NLKLIEPL 161
+++G + YL QGT+ PD IES K IK+HHN L L + +++EPL
Sbjct: 374 VKKLGLQPEDVYLAQGTLRPDLIESSSKTVSGVADVIKTHHNDTELVRILRDSGRVVEPL 433
Query: 162 RDLYKDEVRELAKFLGLPEKIYNRMPFPGPGLAVRVI----------------------G 199
+D +KDEVREL K LGL + + R PFPGPGLA+R+I G
Sbjct: 434 KDYHKDEVRELGKSLGLSDSLVWRQPFPGPGLAIRIICADEPYLVNYDFTNNVVQYLVTG 493
Query: 200 EVTPE-----KIRIVREANAIVEEEVERAGLRPWQAFAVLLGVKTVGVQGDIRAYKETIA 254
E + E KI+I ++ + + ++ ++P VLL ++TV VQGD R Y +
Sbjct: 494 EASSELESEVKIKIDKQLTEMKCKRQDKITIKP-----VLLPIQTVVVQGDGRTYSYLLG 548
Query: 255 VRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLY 295
+ E+ + +PW + +A I + RV++
Sbjct: 549 LYSSEN-----STIDQIPWSYIFNLARTIPKICHNINRVVF 584
>sp|Q09580|GUAA_CAEEL PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (GLUTAMINE
AMIDOTRANSFERASE) >gi|7506029|pir||T23742 hypothetical
protein M106.4 - Caenorhabditis elegans
>gi|3878715|emb|CAA87052.1| (Z46935) contains similarity
to Pfam domain: PF00117 (Glutamine amidotransferase
class-I), Score=162.2, E-value=2.8e-45, N=1; PF00958
(GMP synthase C terminal domain), Score=446.3,
E-value=8.3e-131, N=1~cDNA EST EMBL:M88983 comes from
this gene~cDNA ES>
Length = 792
Score = 154 bits (385), Expect = 1e-36
Identities = 116/363 (31%), Positives = 171/363 (46%), Gaps = 77/363 (21%)
Query: 11 VKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAIG-DKLHAVFVNTGFLRKGEPEFVVKT 69
+ EI VGD K ++ +SGGVDS+ A L +A+G +++ A+ ++ GF+R E + V K+
Sbjct: 310 ISEINSIVGDKKVLVMVSGGVDSAVCAALLRRALGPNRVTAIHIDNGFMRHEESDAVEKS 369
Query: 70 FRDEFGMNLHYVDAQDRFFS----------ALKGVTDPEEKRKIIGRVFIEVFEEVAREI 119
+ +H + F S AL DPE KRKIIG FI V + + +++
Sbjct: 370 LA-ALDLPIHRYNFGTTFRSSTEHCKDGEVALDECDDPEMKRKIIGNTFIRVKDVIMKDL 428
Query: 120 GAE----YLIQGTIAPDWIESQGK--------IKSHHNVGGLPERLNL--KLIEPLRDLY 165
+L QGT+ PD IES IK+HHN L L K++EPL+D +
Sbjct: 429 NINHDEYFLAQGTLRPDLIESASALASGHADTIKTHHNDTFLVRELRKLGKVVEPLKDFH 488
Query: 166 KDEVRELAKFLGLPEKIYNRMPFPGPGLAVRVI-----------------GEVTPEKIRI 208
KDEVREL K LGLPE I R PFPGPGLA+R++ G+V I +
Sbjct: 489 KDEVRELGKDLGLPESIVQRHPFPGPGLAIRILCASDKRPELMFNGPMYNGDVQGRIIDV 548
Query: 209 VRE-------------------------ANAIVEEEVERAGLRPWQAFAVLLGVKTVGVQ 243
+ ++ E + + A + +Q A +L +KTVGVQ
Sbjct: 549 TEQFLNSAINPSQGIYEHLQFEQARNNVLLSLSERDRQLAEQQTFQISAHILPIKTVGVQ 608
Query: 244 GDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPPA 303
GD R+Y +A ++ +PW++L A I V RV+Y +K
Sbjct: 609 GDARSYSYAVA---------LSTEQRPIPWKLLFAYASVIPKLFHGVNRVVYAFGSKIEF 659
Query: 304 TIE 306
+IE
Sbjct: 660 SIE 662
>gb|AAF53975.1| (AE003669) CG9242 gene product [Drosophila melanogaster]
Length = 683
Score = 146 bits (365), Expect = 3e-34
Identities = 119/350 (34%), Positives = 177/350 (50%), Gaps = 76/350 (21%)
Query: 8 EEKVKEIRETVGDSKAIIALSGGVDSSTAAVLAYKAI-GDKLHAVFVNTGFLRKGEPEFV 66
EE ++ IRE VG++K ++ +SGGVDSS A L +A+ ++ AV V+ GF+RK E E V
Sbjct: 216 EECIRYIREKVGNNKVLLLVSGGVDSSVCAALLRRALYPHQIIAVHVDNGFMRKKESEKV 275
Query: 67 VKTFRDEFGMNLHYVDAQDRFFSALKGVT--------------------DPEEKRKIIGR 106
++ RD G++L + ++ LKG T +PEEKRKIIG
Sbjct: 276 ERSLRD-IGIDLI---VRKEGYTFLKGTTQVKRPGQYSVVETPMLCQTYNPEEKRKIIGD 331
Query: 107 VFIEVFEEVAREIGAE----YLIQGTIAPDWIESQGK--------IKSHHNVGGLPERLN 154
+F++V +V E+ + L QGT+ PD IES IK+HHN L L
Sbjct: 332 IFVKVTNDVVAELKLKPEEVMLAQGTLRPDLIESASSMVSTNAETIKTHHNDTDLIRELR 391
Query: 155 L--KLIEPLRDLYKDEVRELAKFLGLPEKIYNRMPFPGPGLAVRVI--GEVTPEK----- 205
+++EPL D +KDEVR+L LGLP+++ R PFPGPGLA+RV+ E EK
Sbjct: 392 NAGRVVEPLCDFHKDEVRDLGNDLGLPQELVERQPFPGPGLAIRVLCAEEAYMEKDYSET 451
Query: 206 ---IRIV-------REANAIVE------EEVERAGL----RPWQAFAVLLGVKTVGVQGD 245
IR++ ++ +A++ E E+ L Q A LL +++VGVQGD
Sbjct: 452 QVIIRVIVDYKNKLQKNHALINRVTAATSEAEQKDLMRISSNSQIQATLLPIRSVGVQGD 511
Query: 246 IRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLY 295
R+Y + + + + W+ L +A I + V RV Y
Sbjct: 512 KRSYSYVVGL----------STSQEPNWQDLLFLAKIIPRILHNVNRVCY 551
>gi|11432448 guanine monphosphate synthetase [Homo sapiens]
Length = 400
Score = 121 bits (301), Expect = 9e-27
Identities = 95/253 (37%), Positives = 122/253 (47%), Gaps = 55/253 (21%)
Query: 86 RFFSALKGVTDPEEKRKIIGRVFIEVFEEVAREIGAE----YLIQGTIAPDWIES----- 136
R L T PEEKRKIIG F+++ EV E+ + +L QGT+ PD IES
Sbjct: 29 RISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVA 88
Query: 137 QGK---IKSHHNVGGLPERLNL--KLIEPLRDLYKDEVRELAKFLGLPEKIYNRMPFPGP 191
GK IK+HHN L +L K+IEPL+D +KDEVR L + LGLPE++ +R PFPGP
Sbjct: 89 SGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGP 148
Query: 192 GLAVRVIGEVTPEKIRIVREANAIV-------------------------EEEVER---- 222
GLA+RVI P + E N I+ EE+ E+
Sbjct: 149 GLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQI 208
Query: 223 AGLRPWQAFAVLLGVKTVGVQGDIRAYKETIAVRIVESLDGMTANAMNVPWEVLQRIAFR 282
L AF LL +KTVGVQGD R+Y + + D WE L +A
Sbjct: 209 TSLHSLNAF--LLPIKTVGVQGDCRSYSYVCGISSKDEPD----------WESLIFLARL 256
Query: 283 ITSEIPEVGRVLY 295
I V RV+Y
Sbjct: 257 IPRMCHNVNRVVY 269
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.140 0.399
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 113235448
Number of Sequences: 2977
Number of extensions: 4855507
Number of successful extensions: 14206
Number of sequences better than 1.0e-10: 51
Number of HSP's better than 0.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 13988
Number of HSP's gapped (non-prelim): 59
length of query: 308
length of database: 189,106,746
effective HSP length: 56
effective length of query: 252
effective length of database: 155,591,474
effective search space: 39209051448
effective search space used: 39209051448
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)