BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2423 (top-RG) DE:reverse gyrase (top-RG)
(1214 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||H75034 reverse gyrase (top-rg) PAB2423 - Pyrococcus abyssi ... 2412 0.0
gb|AAB49283.1| (U66557) reverse gyrase [Pyrococcus furiosus] 2128 0.0
pir||C71129 probable reverse gyrase - Pyrococcus horikoshii >gi|... 1728 0.0
pir||F72609 probable reverse gyrase APE1340 - Aeropyrum pernix (... 957 0.0
pir||B70376 reverse gyrase - Aquifex aeolicus >gi|2983417|gb|AAC... 927 0.0
pir||G70399 reverse gyrase - Aquifex aeolicus >gi|2983618|gb|AAC... 861 0.0
gb|AAK40747.1| Reverse gyrase (topR-1) [Sulfolobus solfataricus] 834 0.0
sp|Q08582|TOPG_SULAC REVERSE GYRASE [INCLUDES: HELICASE; TOPOISO... 827 0.0
gi|11498629 reverse gyrase (top-RG) [Archaeoglobus fulgidus] >gi... 815 0.0
pir||C72409 reverse gyrase - Thermotoga maritima (strain MSB8) >... 810 0.0
pir||G72614 probable reverse gyrase APE1376 - Aeropyrum pernix (... 788 0.0
pir||G64488 reverse gyrase (intein-containing) - Methanococcus j... 736 0.0
gb|AAK41237.1| Reverse gyrase (topR-2) [Sulfolobus solfataricus] 684 0.0
pir||T29099 reverse gyrase - Sulfolobus shibatae >gi|1679872|emb... 671 0.0
pir||T18550 reverse gyrase chain B homolog rgyB - Methanopyrus k... 570 e-161
gb|AAA96962.1| (U41058) reverse gyrase A subunit [Methanopyrus k... 277 7e-73
pir||B81266 DNA topoisomerase (EC 5.99.1.2) I Cj1686c [imported]... 259 1e-67
sp|O66893|TOP1_AQUAE DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 254 6e-66
sp|P46799|TOP1_THEMA DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 253 1e-65
sp|Q9KA23|TOP1_BACHD DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 242 1e-62
sp|P39814|TOP1_BACSU DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 241 3e-62
sp|O34204|TOP1_FERIS DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 239 1e-61
pir||H81236 DNA topoisomerase I NMB0118 [imported] - Neisseria m... 237 6e-61
pir||A82009 DNA topoisomerase (EC 5.99.1.2) I NMA0156 [imported]... 237 6e-61
pir||G64119 DNA topoisomerase (EC 5.99.1.2) - Haemophilus influe... 236 1e-60
sp|P43012|TOP1_HAEIN DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 236 1e-60
pir||D83269 DNA topoisomerase I PA3011 [imported] - Pseudomonas ... 233 9e-60
pdb|1ECL| Amino Terminal 67kda Domain Of Escherichia Coli Dna ... 228 3e-58
sp|P06612|TOP1_ECOLI DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 226 1e-57
pdb|1CY7|A Chain A, Complex Of E.Coli Dna Topoisomerase I With 5... 226 1e-57
sp|Q9KRB2|TOP1_VIBCH DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 224 6e-57
sp|P55991|TOP1_HELPY DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 221 3e-56
emb|CAA71737.1| (Y10747) topoisomerase I [Helicobacter pylori] 220 9e-56
sp|Q9ZMV7|TOP1_HELPJ DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 217 5e-55
sp|O83409|TOP1_TREPA DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 216 1e-54
sp|P73810|TOP1_SYNY3 DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 215 3e-54
pir||B82746 DNA topoisomerase I XF0920 [imported] - Xylella fast... 213 1e-53
sp|Q9X909|TOP1_STRCO DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 212 3e-53
gb|AAD21553.1| (AF088896) topoisomerase I [Zymomonas mobilis] 210 1e-52
sp|Q9ZDK2|TOP1_RICPR DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 205 3e-51
pir||B82870 DNA topoisomerase I UU590 [imported] - Ureaplasma ur... 197 6e-49
sp|Q59567|TOP1_MYCTU DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 196 1e-48
sp|P57371|TOP1_BUCAI DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 195 3e-48
pir||H81749 DNA topoisomerase I TC0012 [imported] - Chlamydia mu... 192 1e-47
pir||G75403 DNA topoisomerase I - Deinococcus radiodurans (strai... 190 7e-47
sp|O69548|TOP1_MYCLE DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 188 4e-46
pir||D72038 DNA topoisomerase I CP1103 [imported] - Chlamydophil... 188 4e-46
sp|P47368|TOP1_MYCGE DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 185 3e-45
pir||A75055 DNA topoisomerase I (topa) PAB1430 - Pyrococcus abys... 180 6e-44
gi|10956714 topoisomerase I [Xylella fastidiosa] >gi|11279673|pi... 180 8e-44
pir||A71488 probable DNA topoisomerase I-fused to SWI domain - C... 179 2e-43
pir||E71106 probable DNA topoisomerase I - Pyrococcus horikoshii... 179 2e-43
sp|P78032|TOP1_MYCPN DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 176 2e-42
pir||B64506 DNA topoisomerase (EC 5.99.1.2) - Methanococcus jann... 171 4e-41
pir||G71870 topoisomerase I - Helicobacter pylori (strain J99) >... 171 5e-41
pir||T04488 DNA topoisomerase homolog F8F16.30 - Arabidopsis tha... 161 5e-38
sp|O51768|TOP1_BORBU DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 161 5e-38
gb|AAF36767.1| (L35043) DNA topoisomerase I [Mycoplasma gallisep... 158 3e-37
pir||H64574 DNA topoisomerase I - Helicobacter pylori (strain 26... 150 1e-34
sp|P34185|TOP1_SYNP7 DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXI... 144 5e-33
pir||A69084 DNA topoisomerase I - Methanobacterium thermoautotro... 140 8e-32
pir||JC5211 DNA topoisomerase (EC 5.99.1.2) I - Mycobacterium tu... 123 1e-26
emb|CAC11211.1| (AL445063) DNA topoisomerase III beta related pr... 119 2e-25
gi|11499394 DNA topoisomerase I (topA) [Archaeoglobus fulgidus] ... 118 4e-25
gb|AAF71288.1|AF255733_1 (AF255733) DNA topoisomerase III alpha ... 114 7e-24
pir||F71871 topoisomerase I - Helicobacter pylori (strain J99) >... 112 3e-23
sp|O60126|TOP3_SCHPO DNA TOPOISOMERASE III >gi|7490479|pir||T396... 111 4e-23
gb|AAK41190.1| DNA topoisomerase I family A (topA) [Sulfolobus s... 109 1e-22
pdb|1CYY|B Chain B, Crystal Structure Of The 30 Kda Fragment Of ... 106 2e-21
pir||H72563 probable DNA topoisomerase APE1794 - Aeropyrum perni... 104 5e-21
sp|O96651|TOP3_DROME DNA TOPOISOMERASE III >gi|4235475|gb|AAD132... 100 1e-19
gb|AAF46144.1| (AE003437) Top3beta gene product [Drosophila mela... 100 1e-19
gb|AAC26106.1| (AF042825) DNA topoisomerase I [Pyrococcus furiosus] 99 3e-19
gi|6755851 topoisomerase (DNA) III beta; Topo III beta [Mus musc... 98 5e-19
dbj|BAB07106.1| (AP001518) DNA topoisomerase III [Bacillus halod... 98 6e-19
emb|CAB60424.1| (AL117203) predicted using Genefinder~contains s... 97 1e-18
gi|4507635 topoisomerase (DNA) III beta; topoisomerase III beta ... 96 2e-18
dbj|BAA96895.1| (AB019227) DNA topoisomerase III [Arabidopsis th... 95 5e-18
pir||H69724 DNA topoisomerase III topB - Bacillus subtilis >gi|1... 94 9e-18
pir||S45077 hypothetical protein gamma - Streptococcus pyogenes ... 90 1e-16
gb|AAC38606.1| (AF007787) type I topoisomerase [Enterococcus fae... 90 1e-16
sp|O61660|TOP3_CAEEL DNA TOPOISOMERASE III >gi|11270818|pir||T43... 87 2e-15
emb|CAB60518.1| (AL132860) contains similarity to Pfam domain: P... 85 3e-15
gb|AAG18918.1| (AE004994) DNA topoisomerase I; TopA [Halobacteri... 82 3e-14
>pir||H75034 reverse gyrase (top-rg) PAB2423 - Pyrococcus abyssi (strain Orsay)
>gi|5458686|emb|CAB50173.1| (AJ248287) reverse gyrase
(top-RG) [Pyrococcus abyssi]
Length = 1214
Score = 2412 bits (6183), Expect = 0.0
Identities = 1214/1214 (100%), Positives = 1214/1214 (100%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW 60
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW
Sbjct: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW 60
Query: 61 EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS 120
EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS
Sbjct: 61 EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS 120
Query: 121 IYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIK 180
IYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIK
Sbjct: 121 IYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIK 180
Query: 181 DGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVIN 240
DGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVIN
Sbjct: 181 DGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVIN 240
Query: 241 RAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSA 300
RAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSA
Sbjct: 241 RAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSA 300
Query: 301 RGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDK 360
RGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDK
Sbjct: 301 RGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDK 360
Query: 361 GIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHL 420
GIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHL
Sbjct: 361 GIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHL 420
Query: 421 IRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIP 480
IRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIP
Sbjct: 421 IRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIP 480
Query: 481 QYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVE 540
QYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVE
Sbjct: 481 QYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVE 540
Query: 541 GKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIK 600
GKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIK
Sbjct: 541 GKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIK 600
Query: 601 KFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQP 660
KFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQP
Sbjct: 601 KFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQP 660
Query: 661 SKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIK 720
SKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIK
Sbjct: 661 SKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIK 720
Query: 721 RCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIA 780
RCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIA
Sbjct: 721 RCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIA 780
Query: 781 WDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELS 840
WDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELS
Sbjct: 781 WDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELS 840
Query: 841 QKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVK 900
QKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVK
Sbjct: 841 QKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVK 900
Query: 901 EVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS 960
EVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS
Sbjct: 901 EVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS 960
Query: 961 IHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
IHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL
Sbjct: 961 IHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
Query: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVK 1080
PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVK
Sbjct: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVK 1080
Query: 1081 PLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLL 1140
PLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLL
Sbjct: 1081 PLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLL 1140
Query: 1141 QRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEV 1200
QRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEV
Sbjct: 1141 QRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEV 1200
Query: 1201 LRELHEEIKRYIRS 1214
LRELHEEIKRYIRS
Sbjct: 1201 LRELHEEIKRYIRS 1214
>gb|AAB49283.1| (U66557) reverse gyrase [Pyrococcus furiosus]
Length = 1214
Score = 2128 bits (5452), Expect = 0.0
Identities = 1036/1214 (85%), Positives = 1146/1214 (94%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW 60
MKAIYR MCPNC GAITDERLA KNPC+ CL EPI +DY +LV A+R ALKL+G LK+W
Sbjct: 1 MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEW 60
Query: 61 EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS 120
E++Y LNKEV E+E+LFK+ATGF FWSAQR+WVKRI++GKSFSIIAPTGMGKSTFGAF+S
Sbjct: 61 EEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMS 120
Query: 121 IYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIK 180
IYFA+KGK+SYIVVPTTPLVVQTVKKI+ MME+A V V LVYYHGNLKKKEK+EAL++IK
Sbjct: 121 IYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIK 180
Query: 181 DGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVIN 240
G+FDILVTSSQFLATRFDELL+DKR D +FVDDVDAFLKASKNIDRSL++LGF +E+I
Sbjct: 181 SGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIK 240
Query: 241 RAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSA 300
+AWE+IKLKKQLAKLLQ + +EVE+LN+EIE++EREI+RY++EN IGILIVASATGSA
Sbjct: 241 KAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIDRYKKENKIGILIVASATGSA 300
Query: 301 RGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDK 360
RGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPE+S+EE VE LL+ LG+GGLIFVPIDK
Sbjct: 301 RGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDK 360
Query: 361 GIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHL 420
GIE+AE+LTNYLKSKGFKVELVSA++K+GLELFE+ EVDYLVGVATYYGTIVRGLDLPHL
Sbjct: 361 GIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHL 420
Query: 421 IRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIP 480
+RFA+F GVPKFRFS+DLEQPTIYRVLGLMSEILEFLP+EKR EGEKLYARLRRLIRNIP
Sbjct: 421 VRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIP 480
Query: 481 QYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVE 540
QYELMKIEEALAEG+ELEGF+NHVL+VFKQAVEFLRE L+DEEV+++I+ENPFLSLK++E
Sbjct: 481 QYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIE 540
Query: 541 GKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIK 600
GK YIEIPDVRTYIQASGRTSRLFAGGITKGLSVI+VDDQKVFNGLIRQMRWRFVEFEIK
Sbjct: 541 GKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIK 600
Query: 601 KFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQP 660
EIN+E VL+EID DR+KVRLV+EGKISEQVKDLVKSALMIVESPNKARTIA+FFGQP
Sbjct: 601 PLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQP 660
Query: 661 SKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIK 720
SKRRIG+LVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVL+L+ GK Y+VPVYDTIK
Sbjct: 661 SKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIK 720
Query: 721 RCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIA 780
RCRDCGHQFVDWE+KGVCP+CGSRNV+DALENVKAMR+LA EVDEILIGTDPDTEGEKIA
Sbjct: 721 RCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIA 780
Query: 781 WDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELS 840
WDIRNVLSPY P IKRIEFHEVTRPAIL+AI EARDINEDRV AQLVRRIEDRWIGFELS
Sbjct: 781 WDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELS 840
Query: 841 QKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVK 900
QKLWEVFEN NLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLEN I+I +E G+V+
Sbjct: 841 QKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQ 900
Query: 901 EVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS 960
EV VK+V IEEREINPLPPYTTDAMLQDASRFLGFS T TMQLAQDLFELGL TYHRTDS
Sbjct: 901 EVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSPTHTMQLAQDLFELGLTTYHRTDS 960
Query: 961 IHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
IHVSNTGIEIAKEYI++EIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL
Sbjct: 961 IHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
Query: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVK 1080
PRNLTKDHF+LYDLIFRRF+ASQMKPA+VLYE+A+I TP+G+VE+EGYI+++YDGWSR+K
Sbjct: 1021 PRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIK 1080
Query: 1081 PLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLL 1140
PLPLK++P+LEK Q LKVTEI++WRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLL
Sbjct: 1081 PLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLL 1140
Query: 1141 QRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEV 1200
QRGYVIETK +KKLVPTEKGIKVY YLVSKYKDLVSEERTRQLEK+MD +EEAKA+YQEV
Sbjct: 1141 QRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEV 1200
Query: 1201 LRELHEEIKRYIRS 1214
L EL+EEI RY++S
Sbjct: 1201 LNELYEEILRYVKS 1214
>pir||C71129 probable reverse gyrase - Pyrococcus horikoshii
>gi|3257210|dbj|BAA29893.1| (AP000003) 1624aa long
hypothetical reverse gyrase [Pyrococcus horikoshii]
Length = 1624
Score = 1728 bits (4427), Expect = 0.0
Identities = 841/954 (88%), Positives = 922/954 (96%), Gaps = 1/954 (0%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW 60
MKAIYRGMCPNC GAITDERL+ KNPCEGCLSEPI +EDY +L+ AVRNALKLRGTLKDW
Sbjct: 1 MKAIYRGMCPNCRGAITDERLSNKNPCEGCLSEPILSEDYNELIVAVRNALKLRGTLKDW 60
Query: 61 EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS 120
E+LYRLNKEVSE+E+LF+++TGF+FWSAQRTWVKRI+RGKSFSIIAPTGMGKSTFGAFIS
Sbjct: 61 EELYRLNKEVSEIEELFEKSTGFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFIS 120
Query: 121 IYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIK 180
IYFA KGK+SYIVVPTTPLV+QTVKKI+ M+E+A V+VRLVYYHGNL+KKEKEEAL++I+
Sbjct: 121 IYFATKGKKSYIVVPTTPLVIQTVKKIESMLEKANVSVRLVYYHGNLRKKEKEEALEKIR 180
Query: 181 DGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVIN 240
+GDFDIL+TSSQFLATRF ELL+DK+FDLIFVDDVDAFLKASKNIDRSL++LGF++E+I
Sbjct: 181 NGDFDILITSSQFLATRFKELLKDKKFDLIFVDDVDAFLKASKNIDRSLIMLGFSEEIIG 240
Query: 241 RAWEVIKLKKQLAKLLQAQGK-EKEVEELNKEIEKIEREIERYRRENNIGILIVASATGS 299
RAWEVIKLKKQLAKLLQ + K E+E+E+LNKEIEKIE EIE Y+R N IGILIVASATGS
Sbjct: 241 RAWEVIKLKKQLAKLLQNEKKNEEEIEKLNKEIEKIEDEIEEYKRRNKIGILIVASATGS 300
Query: 300 ARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPID 359
A+GDRIKLYRELLGFEVGSGRSVLRNIVDTY++PE+ IEE V LLRKLGKGGLIFVPID
Sbjct: 301 AKGDRIKLYRELLGFEVGSGRSVLRNIVDTYLLPEKPIEEHVVELLRKLGKGGLIFVPID 360
Query: 360 KGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPH 419
KGIE+AEELT+YLKS+GFKVELVSAKNK+GLELFE+GE+DYLVGVATYYGT+VRGLDLPH
Sbjct: 361 KGIEYAEELTDYLKSQGFKVELVSAKNKKGLELFEKGEIDYLVGVATYYGTLVRGLDLPH 420
Query: 420 LIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNI 479
LIRFA+F GVPKFRFSMDLEQPTIYRVLGLMSEILEFLP+EK+ EGEKLYARLRRLIRNI
Sbjct: 421 LIRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEEKKSEGEKLYARLRRLIRNI 480
Query: 480 PQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEV 539
PQYELMKIEEALAEG+ELEGFHNHVL+VFKQ+VEFLREVL+DEEVI++I+ENPFLSLKE+
Sbjct: 481 PQYELMKIEEALAEGLELEGFHNHVLEVFKQSVEFLREVLKDEEVIKKIAENPFLSLKEI 540
Query: 540 EGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEI 599
EGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEF+I
Sbjct: 541 EGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFDI 600
Query: 600 KKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQ 659
KKFEE+NL+ VL+EID DR+KV+LVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQ
Sbjct: 601 KKFEEVNLKEVLKEIDRDREKVKLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQ 660
Query: 660 PSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTI 719
PSKR+IG+L AYEVSIGDKMLTILASGGHMFDLVT EGYHGVLILK++GKPY+VPVYDTI
Sbjct: 661 PSKRKIGDLTAYEVSIGDKMLTILASGGHMFDLVTNEGYHGVLILKNNGKPYFVPVYDTI 720
Query: 720 KRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKI 779
KRCRDCGHQFVDWEQKGVCP+CGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKI
Sbjct: 721 KRCRDCGHQFVDWEQKGVCPRCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKI 780
Query: 780 AWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFEL 839
AWDIRNVL+PY PNIKRIEFHEVTRPAIL+AI+EARDINEDRV AQLVRRIEDRWIGFEL
Sbjct: 781 AWDIRNVLAPYAPNIKRIEFHEVTRPAILRAIREARDINEDRVNAQLVRRIEDRWIGFEL 840
Query: 840 SQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEV 899
SQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLG+ LENGI++TIENAKGEV
Sbjct: 841 SQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGIILENGINVTIENAKGEV 900
Query: 900 KEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLC 953
+EVEVKDV+IEE+++NPLPPYTTD MLQDASRFLGFSATKTMQLAQDLFE GLC
Sbjct: 901 REVEVKDVIIEEKDVNPLPPYTTDTMLQDASRFLGFSATKTMQLAQDLFEAGLC 954
Score = 490 bits (1247), Expect = e-137
Identities = 231/261 (88%), Positives = 255/261 (97%)
Query: 953 CTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQL 1012
CTYHRTDSIHVSNTGIE+AKEYI++EIGEEYF PRKWGEEGAHEAIRPTRPIDTGRLIQL
Sbjct: 1364 CTYHRTDSIHVSNTGIEVAKEYITQEIGEEYFTPRKWGEEGAHEAIRPTRPIDTGRLIQL 1423
Query: 1013 IRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL 1072
IRDGIIT+P+NLT+DHFRLYDLIFRRF+ASQMKPA++LYEKAIISTPF DVEVEGYI++L
Sbjct: 1424 IRDGIITIPKNLTRDHFRLYDLIFRRFMASQMKPAKILYEKAIISTPFKDVEVEGYIDVL 1483
Query: 1073 YDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTY 1132
YDGWS++K LPL+QIPKLEKGQ+L+V E+KQWRAPKVSLYTQGDVIALMKERGIGRPSTY
Sbjct: 1484 YDGWSKIKSLPLRQIPKLEKGQRLRVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTY 1543
Query: 1133 AKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEE 1192
AKIVQTLLQRGYVIETKG+KKLVPTEKGIKVYQYL++KYKDLVSEERTRQLEKIMD +EE
Sbjct: 1544 AKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLITKYKDLVSEERTRQLEKIMDMVEE 1603
Query: 1193 AKADYQEVLRELHEEIKRYIR 1213
AKADYQ+VL EL+EEIKRY+R
Sbjct: 1604 AKADYQDVLNELYEEIKRYVR 1624
>pir||F72609 probable reverse gyrase APE1340 - Aeropyrum pernix (strain K1)
>gi|5105018|dbj|BAA80332.1| (AP000061) 1376aa long
hypothetical reverse gyrase [Aeropyrum pernix]
Length = 1376
Score = 957 bits (2448), Expect = 0.0
Identities = 571/1334 (42%), Positives = 801/1334 (59%), Gaps = 150/1334 (11%)
Query: 2 KAIYRGMCPNCGGAITDERLAEKNPCEGCLSE-PIKAEDYEKLVFAVRNALKLRGTL-KD 59
+ +YR +CPNCGG ++ERL+ PC CL P K + L+ GTL
Sbjct: 15 RGVYRYLCPNCGGPNSEERLSRGLPCPRCLPRLPRKGVSGWT---GLARLLRREGTLGAG 71
Query: 60 WEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFI 119
+ + L +E + F++A G W AQRTW KR+ RG SFSIIAPTG+GK+TFGA
Sbjct: 72 VKAMASLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAA 131
Query: 120 SIYFAIK-GKRSYIVVPTTPLVVQTVKKIQDMMERAGVN-VRLVYYHGNLKKKEKEEALK 177
S+++A K G RSYIV+PTT L +K++ M+E G VRL+ H LK E+ EA++
Sbjct: 132 SLFYACKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAME 191
Query: 178 RIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQE 237
R + GDFDILVT++ F A ++ + L RF L+FVDDVDA L++++++D L ++GF +E
Sbjct: 192 RFEKGDFDILVTTAAF-ARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEE 250
Query: 238 VINRAWEVIKLKKQLAKL---LQAQGKE------KEVEELNKEIEKIEREIERYRRENNI 288
I + EV++L+++ A+L LQ+Q +E K++ E+ + +E++E EIE R
Sbjct: 251 AIEKGLEVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIEA--RRGRT 308
Query: 289 GILIVASATGSARGDRIKLYRELLGFEVGSGRSV-LRNIVDTYIIPERSIEEEVENLLRK 347
LIV+SATG RG R++L+R LL FE G + LR ++D+Y P + E+V L+R+
Sbjct: 309 ASLIVSSATGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRR 368
Query: 348 LGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFER---GEVDYLVGV 404
LG GGL++VPID G+E+AE L L+ G K E AK + LEL +R GE+D LVGV
Sbjct: 369 LGTGGLVYVPIDMGVEYAERLAEELRRAGVKAEAYHAK--KPLELLDRFAEGEIDVLVGV 426
Query: 405 ATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREE 464
A YYGT+VRGLDLP +R+AVFAGVP+ +F D+ P R+L L+S + E +E
Sbjct: 427 ANYYGTLVRGLDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASA 486
Query: 465 GEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEV 524
RLRR++R + L I E +A G G+ VL+ + +FLRE L ++V
Sbjct: 487 ARSHMGRLRRMLRVLSPAALQMIAERVARGEVEGGYDRQVLEAY----QFLREALARDDV 542
Query: 525 IRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFN 584
+ E ++E G+ YI +PD TY+QASGRTSRL+AGGIT GLSV++VD++ V
Sbjct: 543 WESLRELDVGIVRE-GGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMR 601
Query: 585 GLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIV 644
GL++++ W E + ++FE+++L+S+LREIDEDR+KVR V++G + +LV++AL++V
Sbjct: 602 GLMKRVSW-MAEVDWRRFEDLDLQSILREIDEDREKVRRVVKGLY--RGVELVRTALLVV 658
Query: 645 ESPNKARTIASFFGQPSKRRI-GELVAYEVSIGDKMLTILASGGHMFDLVTT-------- 695
ESPNKARTIA FFGQPS R + G YEV+ GDK+L I+ASGGH+FDLV
Sbjct: 659 ESPNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEA 718
Query: 696 ------EGYHGVLI--LKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVH 747
GVL L +G Y PVY +IKRC DCG+QFVD + CP+CGS +
Sbjct: 719 AGGEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVDEASR--CPRCGSELIR 776
Query: 748 DALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAI 807
++L V+ +R +A E DE+ +GTDPDTEGEKI WD+ L PY P+IKR+EFHEVT+ AI
Sbjct: 777 NSLSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAI 836
Query: 808 LKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLW-------------EVFENR---- 850
L+A+ R +++ V AQ+VRR+EDRWIGF LS LW E E R
Sbjct: 837 LEALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMD 896
Query: 851 -----------NLSAGRVQTPVLGWIVQR----------YKEFTESETDFLGLT----LE 885
NLSAGRVQTP LGW+V R Y+ +S+ F + +
Sbjct: 897 RERCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVP 956
Query: 886 NGISITIENAKGEVKE------VEVKDVVIEER--EINPLPPYTTDAMLQDASRFLGFSA 937
+ ++N K+ ++VK VV +E + P PPYTTD ML+DA+R LG +
Sbjct: 957 ESVKRVLDNWVKHHKKTGIEPWLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGS 1016
Query: 938 TKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIG---EEYFAPRKWGEEGA 994
+ M++AQDLFE GL TYHRTDS VS+ G+++A+E++ G + + PR+WGE GA
Sbjct: 1017 AEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGA 1076
Query: 995 HEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPA---RVLY 1051
HEAIRP RPID RL L+ +G+I LP LT+ H RLYDLIFRRF+ASQM+ A RV+Y
Sbjct: 1077 HEAIRPVRPIDVERLQLLVEEGVIELPGTLTRRHLRLYDLIFRRFMASQMREADALRVVY 1136
Query: 1052 EKAIISTPFGDVEVEGYIEILYDG------------WSRVKPLPLKQIPKLEKGQKLKV- 1098
+ + +E +EI G W V+P P+L +G++ +
Sbjct: 1137 RLRVPELDGYTLTLERVVEIGRPGDAEGVTRGFTLVWPYVRPQ-----PRLVEGREAWIR 1191
Query: 1099 TEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIET-----KGRKK 1153
++ + PK YT+G+++ MK RGIGRPSTYAKIV+TL +R YVIE +G
Sbjct: 1192 ARVEGRQVPKAYPYTEGEIVEEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGF 1251
Query: 1154 LVPTEKGIKVYQYLVSKYK-------------------DLVSEERTRQLEKIMDEIEEAK 1194
+V T +GI VY YL + + LVSE+RTR+LE+ MD +E+
Sbjct: 1252 VVATSRGINVYNYLTEELRSADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGD 1311
Query: 1195 ADYQEVLRELHEEI 1208
A +VL + EI
Sbjct: 1312 ASRDDVLESVFNEI 1325
>pir||B70376 reverse gyrase - Aquifex aeolicus >gi|2983417|gb|AAC07000.1|
(AE000712) reverse gyrase [Aquifex aeolicus]
Length = 1146
Score = 927 bits (2370), Expect = 0.0
Identities = 538/1226 (43%), Positives = 779/1226 (62%), Gaps = 101/1226 (8%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDY-EKLVF-AVRNALKLRGTLK 58
+KAI+ +CPNCGG I+ ERL + PCE CL E + E+ +KL + + +L LK
Sbjct: 2 IKAIFDTLCPNCGGEISAERLLKGLPCEKCLPEEVNREEVCQKLENGSFKEFCELLSELK 61
Query: 59 DWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAF 118
DWED FK G WS Q++W +++ G+SF+++APTG+GK+TFG
Sbjct: 62 DWEDF-------------FKEILGTSPWSLQKSWARKVFLGRSFAMLAPTGVGKTTFGLS 108
Query: 119 ISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKR 178
++ Y A +GK+SYI++PT LV Q ++I+ GV+ + G L +K+K+E +R
Sbjct: 109 MASYLAKQGKKSYIILPTQLLVEQVSERIKTF----GVDEDRLIVWGKLSEKKKKELKER 164
Query: 179 IKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEV 238
I+ GDFDIL+T+S FL ++ L +D F IFVDDVD+FLK +KN+D+ L LLGF++E
Sbjct: 165 IQKGDFDILITTSMFLYKNYEILPKD--FSFIFVDDVDSFLKTAKNVDKVLYLLGFSEED 222
Query: 239 INRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATG 298
I++A+E+I+LK++ K E++ EE+ K E++ REI + ++ G+L V+SATG
Sbjct: 223 IHKAFELIRLKEKPNK------SEEDWEEIKKRSEEL-REIAKKKK----GVLAVSSATG 271
Query: 299 SARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPI 358
+ R +RIKL+RELLGFEVG +LRNIV+TY ++++E + +++ GKGGL+FV
Sbjct: 272 NPRSNRIKLFRELLGFEVGKPSVLLRNIVETYE-ETQNLKETLLKRVKEFGKGGLVFVSS 330
Query: 359 DKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLP 418
D G E EE+ +L+S G K + + L+LFE+GE +G++++ + RG+DLP
Sbjct: 331 DYGREAVEEVKKFLESHGVK----AVTYEEDLKLFEKGEAQVAIGISSFKNPLARGIDLP 386
Query: 419 HLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEK-REEGEKLYARLRRLIR 477
H++R+A+F GVPK R + +E + + L+S L EK + E +K+ ++RL R
Sbjct: 387 HVVRYAIFYGVPKIRVPLKVETSVSHLLWALLSLRPIILKDEKLKSEVKKVDTWIQRLRR 446
Query: 478 NIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLK 537
Y + ++ + E +L+ + + ++ K+ EFL E+++ +I + L+L+
Sbjct: 447 ----YSFLS-DDFVEERPDLK---DRIENLRKEVQEFLLR----EDIVEKIKNSEELTLR 494
Query: 538 EVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEF 597
E + + DV Y+QASGRTSR++AGG+TKGLS ++VDD++ F L +++RW +
Sbjct: 495 LGEEGFELVVADVTGYLQASGRTSRMYAGGLTKGLSHVLVDDRRAFKNLEKKVRWFNQDI 554
Query: 598 EIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFF 657
KK EE++L+ VLREIDEDRKKVR ++EGK+ + K+ VK L++VESPNKARTIA+FF
Sbjct: 555 NFKKIEEVDLKEVLREIDEDRKKVREILEGKVKAEQKEHVKPVLVVVESPNKARTIANFF 614
Query: 658 GQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYD 717
G+P R+IG + EV +GD + I AS GH+FDLV + +HGV+ + YVP+Y+
Sbjct: 615 GKPMGRKIGGIDVLEVMVGDLYIMITASLGHVFDLVKDKEFHGVIAKNGE----YVPIYE 670
Query: 718 TIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGE 777
I+ G N+ VK +RELA EVD +LIGTDPDTEGE
Sbjct: 671 VIE---------------------GKENI------VKGLRELAQEVDTVLIGTDPDTEGE 703
Query: 778 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGF 837
KI WD+ +LSPY PN++RIEFHEVTR AI A++ RD NE+ VKAQLVRRI DRW+GF
Sbjct: 704 KIGWDLGALLSPYIPNVERIEFHEVTRKAIKHAVENPRDFNENLVKAQLVRRIADRWVGF 763
Query: 838 ELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIE---N 894
E+S+ + + F+ LS GRVQ PVLGWI++R K + + + ENG + +
Sbjct: 764 EVSRIVQQAFDKHWLSGGRVQIPVLGWIIEREKLYRKKKHVVQITFKENGRWLRLGFEFQ 823
Query: 895 AKGEVKEV-----EVKDVVIEERE--INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDL 947
K E KE E+ V+EERE NP PP+TTD ML++AS S K MQLAQ+L
Sbjct: 824 DKKEAKEFYENLKEIDVEVLEEREELKNPPPPFTTDTMLKEASDRYRISVPKLMQLAQEL 883
Query: 948 FELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTG 1007
FE GL TYHRTDS VS+ GI +AKE+ISEE+G+E F PR WGE GAHE IRPT+P+D
Sbjct: 884 FEYGLITYHRTDSTRVSDVGIGVAKEWISEELGKELFYPRVWGEGGAHECIRPTKPLDVE 943
Query: 1008 RLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEG 1067
L ++ G + +NLT++H LY+LIF+RF+ASQMKP +V +K + + E+
Sbjct: 944 DLRSMMLAGQL---QNLTREHLLLYELIFKRFMASQMKPVKVKTKKVKVKALGREQELIL 1000
Query: 1068 YIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIG 1127
EIL +G+++V PL L+ P L KG + + P LYTQG ++ MK RGIG
Sbjct: 1001 TTEILEEGFNKVYPLELQ--PDL-KGSVYVEDKKELKSVPMAYLYTQGSLVEEMKRRGIG 1057
Query: 1128 RPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYK--DLVSEERTRQLEK 1185
RPSTYA IV LL+RGYVIE G L+PT+ G +VY++L S+ K VSEE TR+LE+
Sbjct: 1058 RPSTYATIVSKLLERGYVIERHG--FLIPTKLGKQVYEFLKSREKIMPFVSEEFTRKLEE 1115
Query: 1186 IMDEIEEAKADYQEVLRELHEEIKRY 1211
+MD++EE K DY +VL EL++++ +
Sbjct: 1116 LMDKVEEGKEDYLQVLDELYKKVNEF 1141
>pir||G70399 reverse gyrase - Aquifex aeolicus >gi|2983618|gb|AAC07187.1|
(AE000726) reverse gyrase [Aquifex aeolicus]
Length = 1177
Score = 861 bits (2200), Expect = 0.0
Identities = 509/1222 (41%), Positives = 740/1222 (59%), Gaps = 96/1222 (7%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW 60
++ I RG CPNCGG I+ +RL + PC CL +P + + V +AL+ TLK
Sbjct: 21 LELIERG-CPNCGGVISSDRLEKGLPCSKCLPKPTEEK--------VCDALEELKTLKYL 71
Query: 61 EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS 120
+ +K + + F++A G + WS QR W KR+ +SF+I+APTG+GK+TFG +S
Sbjct: 72 KPFCDTDKSLERFINFFEKAVGAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMS 131
Query: 121 IYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIK 180
++ +KG R + PT L Q ++ ++ ++ GVN +++ Y KK +E+ L
Sbjct: 132 LF--LKG-RVLAIFPTRLLAQQAGDRLSELAQKVGVNKKILIYQS--KKNIREQFL---- 182
Query: 181 DGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVIN 240
+GD+DIL+ ++ FL F+ L+ K F LIF+DD+D+FLK KN+D LLGF+ E I
Sbjct: 183 NGDWDILLGTNMFLHKNFENLINFK-FKLIFIDDIDSFLKRGKNVDYLFKLLGFSGEEIK 241
Query: 241 RAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSA 300
A + K ++ +L + + ++++ +LIV+SAT
Sbjct: 242 LALKENKTQRDYDRLARIRKRKRDT------------------------VLIVSSATLKP 277
Query: 301 RGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVEN---LLRKLGKGGLIFVP 357
RG R L+R LLGF+V + LRNIVD P + +EE +E L++KLGKGGL+++
Sbjct: 278 RGKRAYLFRNLLGFDVQKAITTLRNIVDV-AEPVKDLEEALEKSVELIKKLGKGGLVYLS 336
Query: 358 IDKGIEFAEELTNYLKSKGFK-VELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLD 416
+ G + +E+ + + G V + K + ++ E+GE D VG++ +VRG+D
Sbjct: 337 VFYGKDKVQEVKEFYRKHGINAVSYLDYKPEELYQILEKGEFDVAVGISHITNPLVRGID 396
Query: 417 LPHLIRFAVFAGVPKFRF--SMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRR 474
LPH+IR+AVF PK F + L P ++ GL+ +L + R + + L+R
Sbjct: 397 LPHIIRYAVFLDPPKHVFPTELTLSPPLLH---GLLLTLLNLFEGDDRLKAIQYVMYLKR 453
Query: 475 LIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFL 534
L EE L + + + ++ FL L+DE +++I E+ +
Sbjct: 454 Y--------LTLREEQLDN-------YPRIKERVEEIKNFLENYLKDENFLKKIKESEDI 498
Query: 535 SLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRF 594
SL EGKLYI + D +YIQASGRTSR AGG+TKGLSV+ D K F L +++ +
Sbjct: 499 SLVPKEGKLYIVVGDANSYIQASGRTSRFIAGGMTKGLSVVYYSDPKAFYSLKKRLALYY 558
Query: 595 V--EFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKART 652
+ E E K+ E++L +++EIDEDRK+ R +++GK Q+KDL K+ L+IVESPNKART
Sbjct: 559 MTQEIEFKRLSEVDLNKLIKEIDEDRKRAREILQGKGVAQIKDLFKTTLVIVESPNKART 618
Query: 653 IASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYY 712
IA FFG+P R + + VAYEV +GD++L I AS GH+ DLVT +G+ GVL DD PY
Sbjct: 619 IAGFFGKPQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFFGVL---DDTYPY- 674
Query: 713 VPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDP 772
+PVYDTIK CR+ Q ++E + +C + + D LE +K +RE++ EVDE+ I TDP
Sbjct: 675 LPVYDTIKICRETHEQHTEYEY--LKKRCKGK-IEDKLEIIKGVREVSYEVDEVFIATDP 731
Query: 773 DTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIED 832
D EGEKI +D+ + P+ NIKR EFHEVT A +AI+ R+++ + VKAQLVRRI D
Sbjct: 732 DAEGEKIGYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPREVDLNLVKAQLVRRILD 791
Query: 833 RWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITI 892
RW+GF LS LW+ F + LSAGRVQTPVLGW+++RY+E E + + L + + I I
Sbjct: 792 RWVGFTLSHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKEKKGEILLHVNDFPLKIEI 851
Query: 893 EN---AKGEVKEVEVKDVVI---EEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQD 946
E+ AK K++E+ D+ + +E E PLPPYTTD +L+DA+ L SA KTM++ Q+
Sbjct: 852 EDLMFAKEIFKDLELADISLSNPQEEEKRPLPPYTTDTVLEDANEKLHLSAHKTMKILQE 911
Query: 947 LFELGLCTYHRTDSIHVSNTG-IEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPID 1005
LFE G TYHRTDS VS+ G +AK YI++ GEEYF PR WGE GAHE IRPTRP++
Sbjct: 912 LFEAGYITYHRTDSTRVSDAGKYLVAKPYITKMFGEEYFYPRSWGEGGAHECIRPTRPLE 971
Query: 1006 TGRLIQLIRDGIITL--PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDV 1063
L +I GI P N K +Y+LIF+RF+ASQM+PA+V+ E+ I+ P+ +
Sbjct: 972 PKDLEFMITAGIAEFEDPENALK----VYELIFKRFMASQMRPAKVITEEIILKLPYFEW 1027
Query: 1064 EVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKE 1123
+ E+ G+ + P K PK E KL++T + PKV YTQG +I MK
Sbjct: 1028 KERVVTEVKEHGFDLMYP-TFKVFPKKE---KLEITHKEFREVPKVYPYTQGTLIQEMKR 1083
Query: 1124 RGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQL 1183
RG+GRPSTYA+IVQTLL+R YV+E KG L+PT+ G +VY+YL + + SEE TR+L
Sbjct: 1084 RGLGRPSTYAQIVQTLLERHYVVEEKG--FLIPTDLGREVYEYLTKHFPEWTSEELTRKL 1141
Query: 1184 EKIMDEIEEAKADYQEVLRELH 1205
E+ MD+IE + DY EVL+E+H
Sbjct: 1142 EEAMDKIERGELDYMEVLKEVH 1163
>gb|AAK40747.1| Reverse gyrase (topR-1) [Sulfolobus solfataricus]
Length = 1242
Score = 834 bits (2130), Expect = 0.0
Identities = 509/1286 (39%), Positives = 754/1286 (58%), Gaps = 135/1286 (10%)
Query: 3 AIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWED 62
+IY CPNCGG I+ +RL + CE CL + + + L+ N L LK+
Sbjct: 10 SIYTRSCPNCGGNISSQRLFNGSVCESCLKDDREFSNLSDLI----NILSENSNLKNLTQ 65
Query: 63 LYRLNKEVSEVEDLF-KRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISI 121
+ + +E +VE++F K + QR+W R LRG+SF+IIAP G+GK+TFG +S+
Sbjct: 66 IRDVLEEYKKVEEIFGKLLNNSKPIGPQRSWTIRFLRGESFAIIAPPGLGKTTFGLIMSL 125
Query: 122 YFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKD 181
Y A + ++S I+ PT L+ QTV K+ E + R++Y + E L ++K
Sbjct: 126 YNATRNRKSIIIFPTRTLISQTVDKLAKFSELYSYSPRILY--NKQSPTQTENILDQLKS 183
Query: 182 GDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINR 241
G+FDI +++++F+ EL K FD IFVDDVDA LK+ K+ L L+GFT E I
Sbjct: 184 GNFDIFISTNRFVIQNLSELSNIK-FDFIFVDDVDAALKSGKSAKAILRLVGFTDEDIQT 242
Query: 242 AWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSAR 301
++++ + G+E++ ++ +EI R ++ I +I +SAT S R
Sbjct: 243 TMKLLR---------ENIGEEEKFGKI--------QEIRESRLKDKI--VIFSSATIS-R 282
Query: 302 GDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEE---------VENLLRKLGKGG 352
G+ I L+GF GS LRNI D+YI ++ + + V LL++L G
Sbjct: 283 GNPI--LSSLMGFRPGSSVIYLRNIYDSYIDLTQTCKGQDFEECTLGTVIKLLKRLNDGT 340
Query: 353 LIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIV 412
LIFVPIDKG ++A+ L + L+ G VE V++ + LE FERGEV LVGVAT+YG +V
Sbjct: 341 LIFVPIDKGAQYADYLASNLRDHGINVESVASSSISKLEKFERGEVSSLVGVATHYGVLV 400
Query: 413 RGLDLPHLIRFAVFAGVPKFRFSMD--LEQPTIYRVLGLMSEILEFLPQEKREEGEKLYA 470
RG+DLP +++++F G+PKF+F + + + R+L L+ + + ++ L +
Sbjct: 401 RGIDLPWRVKYSIFVGIPKFKFKIGEYMHPLALTRLLSLVYLV------KNDDKVRGLLS 454
Query: 471 RLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISE 530
+R+ +R I L + + + EG +++ + K+A + E L+D E ++++S+
Sbjct: 455 YIRKRLRKISPAALAMLAKDIREG-KIDD------ERLKEAYNLVNEYLKDNEFLKKVSD 507
Query: 531 NPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVF------- 583
L +EG YI +PD TYIQASGRTSRL+ +T GLSV+++D+ ++F
Sbjct: 508 VGDLV---IEGD-YILMPDYLTYIQASGRTSRLYGANLTTGLSVLLIDNSRLFELLNKKL 563
Query: 584 NGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMI 643
N ++ +++W ++ + K +++L + +I E+R+ + + + E VK+ L I
Sbjct: 564 NLILDEVKWYSLDIDADKLGQVSLSDISAKITEERESLSKIKKEGNVESSSLSVKTTLFI 623
Query: 644 VESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEG------ 697
VESPNKA+TI++FF +PS R G+L YE +GD++L + ASGGH++DL+T +
Sbjct: 624 VESPNKAKTISNFFSRPSTRSYGKLRVYETVLGDRVLIVAASGGHIYDLITEDESEKQDD 683
Query: 698 --YHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKA 755
+GVL+ D K ++P+Y TIK+C GHQ V + CP CGSR V D E V
Sbjct: 684 NYVYGVLV--KDSK--FIPIYSTIKKCEK-GHQIVKDLSQNKCPICGSRIVTDKTEVVDI 738
Query: 756 MRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEAR 815
+R+LALEVDE+LIGTDPDTEGEKIAWDI + P+ NIKR EFHEVTR AIL AIK R
Sbjct: 739 LRKLALEVDEVLIGTDPDTEGEKIAWDIYLAIRPFNGNIKRAEFHEVTRRAILNAIKNPR 798
Query: 816 DINEDRVKAQLVRRIEDRWIGFELSQKL----WEVF---------------ENRNLSAGR 856
+ N++ VK+Q+VRRIEDRWIGF+LS+KL WE ENRNLSAGR
Sbjct: 799 EFNDNLVKSQIVRRIEDRWIGFKLSRKLQTEFWEQHCTSISKKNSKDEECKENRNLSAGR 858
Query: 857 VQTPVLGWIVQRYKEFTESETDFLGLTLEN----GISITIENAKGEVKEVEV----KDVV 908
VQTPVL W+V RY+++ E++ +L + ++ S+ G K ++ +D+
Sbjct: 859 VQTPVLDWVVNRYQKYNENKKKYLIIESQDKSIFPFSVLALKKNGLSKNTQIIIHLEDIN 918
Query: 909 IEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGI 968
I+E E PLPPYTTD +L DA+ L A+ TM++AQDLFELGL TYHRTDS VSN GI
Sbjct: 919 IKEEEFGPLPPYTTDTLLSDAANLLRIPASDTMRVAQDLFELGLITYHRTDSTRVSNVGI 978
Query: 969 EIAKEYI-SEEIG-EEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTK 1026
+A+ Y+ S+++ + F PR WGE GAHEAIRPT+P+D L I G + L + LT
Sbjct: 979 SVAETYLKSKQVDISKIFRPRSWGEGGAHEAIRPTKPLDETMLKASIEQGDLELSKQLTF 1038
Query: 1027 DHFRLYDLIFRRFIASQMKPARV--------LYEKAIISTPFGDVEVEGYI--------- 1069
+HFR+Y+LIFRRFI SQ+ P V Y K I + + E I
Sbjct: 1039 NHFRVYNLIFRRFITSQLPPLVVTKQIVRIRAYTKDNIELELDENKKEFVIGYKLKEGDE 1098
Query: 1070 ------EILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKE 1123
+ +Y + +PL K KG++L T V LYT+G++I+ MK
Sbjct: 1099 FRQTLQDAIYTLFRLYQPLDEKM-----KGKELSATITGTLNKSDVQLYTEGELISEMKS 1153
Query: 1124 RGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQL 1183
+ IGRPSTYA I+ TL +R Y+IE+K KK++PT+ G+ V +YL+ YK +VSE+RT +L
Sbjct: 1154 KQIGRPSTYAVIISTLKKRRYIIESKNLKKIIPTKLGMAVKEYLMENYKQIVSEKRTVKL 1213
Query: 1184 EKIMDEIEEAKADYQEVLRELHEEIK 1209
+ M+E+EE K DY +L+EL+ EI+
Sbjct: 1214 LEKMNEVEEGKVDYLVLLKELYNEIQ 1239
>sp|Q08582|TOPG_SULAC REVERSE GYRASE [INCLUDES: HELICASE; TOPOISOMERASE ]
>gi|1076165|pir||A47445 reverse gyrase - Sulfolobus
acidocaldarius >gi|152943|gb|AAA72346.1| (L10651) reverse
gyrase [Sulfolobus acidocaldarius]
Length = 1248
Score = 827 bits (2114), Expect = 0.0
Identities = 486/1275 (38%), Positives = 757/1275 (59%), Gaps = 109/1275 (8%)
Query: 3 AIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWED 62
+IY CPNCG +I+ RL + C CL E ++Y+ + +++ K +G L +D
Sbjct: 10 SIYLFSCPNCGRSISTYRLLLGSVCNICLEED---KEYKNIGDLIKDIEK-QGNLIKLKD 65
Query: 63 LYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIY 122
+ R+ + +F+R GF + Q++W+ R+L G+SF+IIAP G+GK+TFG SIY
Sbjct: 66 IQRVLDDYESFVSVFRRLLGFPPFGPQKSWIYRLLSGESFAIIAPPGLGKTTFGLISSIY 125
Query: 123 FAIKGKRSYIVVPTTPLVVQTVKK----IQDMMERAGVNVRLVYYHGNLKKKEKEEALKR 178
++GK+S +V PT LV Q + K IQ++ E +++YY+ + E++EA +
Sbjct: 126 LYLRGKKSILVFPTKSLVRQAIDKLSSYIQNLAEIKENPPKVIYYYSGMSASERKEADEG 185
Query: 179 IKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEV 238
++ FDI +++++FL D++ + +FVDDVD LK+SK+ L LLGFT
Sbjct: 186 LQSKTFDIFISTNRFLIDNIDQI-SSTSYQFLFVDDVDTALKSSKSAQAILKLLGFTPSD 244
Query: 239 INRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATG 298
++ E +K K +E + N++ E I EI++ R++ ++ S+
Sbjct: 245 QDKIKESLK-------------KYRENTQKNEQNEYIFEEIDKIRKDRLASKTVIFSSAT 291
Query: 299 SARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEE---VENLLRKLGKGGLIF 355
R + I L+GF+ GS +R + D Y+ +E +++LL +LG GGLIF
Sbjct: 292 LNRSNPI--LTSLVGFKPGSSVIYIRKVYDMYVKQPDKEQETFNLIKSLLHRLGDGGLIF 349
Query: 356 VPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGL 415
VP+DK E+ + L + L ++ F V +++ + ++ F GE+D L+G AT+YG +VRGL
Sbjct: 350 VPVDKKQEYIKRLQSELSNE-FNVAAITSTSATKIDDFANGEIDVLIGSATHYGILVRGL 408
Query: 416 DLPHLIRFAVFAGVPKFRFSMD--LEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLR 473
DLP +++++F G+PKF+F + + T+ R+L L++ I K +E + R++
Sbjct: 409 DLPWRVKYSIFVGIPKFKFRLGEKVNLLTLSRLLSLIALIT------KDQEVIYISRRVK 462
Query: 474 RLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPF 533
IR + L + EG +LE + +A + L + L ++ V++RISE
Sbjct: 463 DKIRRLSPAALTMLSVQAKEG-KLED------SILLKAYDLLNKYLSNQNVLKRISEIGD 515
Query: 534 LSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMR-- 591
L L IPD TY+QASGRTSR++AG +T GLS+++VDD +F L ++++
Sbjct: 516 FVLSPDNDIL---IPDYLTYVQASGRTSRIYAGDVTTGLSILLVDDFNLFRLLNKKLQYI 572
Query: 592 -----WRFVEFEIKKFEEINLESVLREIDEDRKKV-RLVIEGKISEQVKDLVKSALMIVE 645
WR ++ E ++ +++++ +I+E+R ++ +L EG ++ ++ VK+ L++VE
Sbjct: 573 LDDIQWRELDVEKWTAGDVEIKNLISKINEERNEISKLKNEGNVAPALQK-VKTVLLVVE 631
Query: 646 SPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE-GYHGVLIL 704
SPNKA+TI+SFF +PS R+IG + YE +GDK+L + ASGGH++DL T + G +GV I+
Sbjct: 632 SPNKAKTISSFFSRPSIRQIGNMRVYETVLGDKVLMVTASGGHVYDLTTQDMGIYGVDIM 691
Query: 705 KDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNV-HDALENVKAMRELALEV 763
K + ++P+Y++IK+C + HQF D+ + CP+C + V +D+L+++ +R LA+E
Sbjct: 692 KQNSSLVFIPIYNSIKKCEN-NHQFTDFFESNKCPRCMTTKVRYDSLKSINVLRNLAVEA 750
Query: 764 DEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVK 823
DE+LIGTDPDTEGEKIAWD+ L PY NI+R EFHEVTR AIL+AI + R+ N + VK
Sbjct: 751 DEVLIGTDPDTEGEKIAWDLYLALRPYNSNIRRAEFHEVTRKAILQAINQPREFNVNLVK 810
Query: 824 AQLVRRIEDRWIGFELSQ----KLWEVF-------------ENRNLSAGRVQTPVLGWIV 866
+QLVRRIEDRWIGF+LS + W + EN+NLSAGRVQTPVL WIV
Sbjct: 811 SQLVRRIEDRWIGFKLSSILQTRFWPEYCKSLSSNKQLNCNENKNLSAGRVQTPVLSWIV 870
Query: 867 QRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVI------EEREINPLPPY 920
RY E+ +++ ++ I I K + K VV+ E E PLPPY
Sbjct: 871 DRYTEYQRNKSRVYYGKIDQLQDIVIYVPKQDGVRKNSKIVVVFNEINQLEEEFGPLPPY 930
Query: 921 TTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIG 980
TTD +L D++ F G SA +TM++AQDLFELGL TYHRTDS +SNTGI +A+ Y+ + +G
Sbjct: 931 TTDTLLSDSNNFFGLSAPETMRIAQDLFELGLITYHRTDSNRISNTGISVAENYLKDVLG 990
Query: 981 EEY---FAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFR 1037
++Y F PR WG+ GAHE IRPT+PID +L LI +G + L + LT +HF++YD+IFR
Sbjct: 991 DKYTNIFKPRSWGDGGAHEGIRPTKPIDVEQLRLLIEEGELELAKRLTNNHFKVYDIIFR 1050
Query: 1038 RFIASQMKPARV--------LYEK----------------AIISTPFGDVEVEGYIEILY 1073
RFI+SQ+ P +V LY + I+ P D E+ + +
Sbjct: 1051 RFISSQIIPLKVRKEIVKIELYGENKKEKINSNQNIIEVITGITLPGIDTEISKFAYVPV 1110
Query: 1074 DGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYA 1133
SR LK++ + + + V+LYTQ D++ MK + IGRPSTYA
Sbjct: 1111 RNVSRSVAERLKELGR-SIPTDFSIEISNSFIKSTVNLYTQADLVMEMKNKKIGRPSTYA 1169
Query: 1134 KIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEA 1193
I+ T+L+RGYV+E+ KKL+PT G++V +YL Y VSE+RTR+L ++MD +E
Sbjct: 1170 TIIGTILRRGYVLESLKTKKLIPTRLGVEVNKYLNENYGRFVSEDRTRKLLQLMDMVEAG 1229
Query: 1194 KADYQEVLRELHEEI 1208
+ Y+EVL++++EEI
Sbjct: 1230 QEKYEEVLKQVYEEI 1244
>gi|11498629 reverse gyrase (top-RG) [Archaeoglobus fulgidus]
>gi|7446075|pir||H69377 reverse gyrase (top-RG) homolog -
Archaeoglobus fulgidus >gi|2649571|gb|AAB90219.1|
(AE001033) reverse gyrase (top-RG) [Archaeoglobus
fulgidus]
Length = 1054
Score = 815 bits (2081), Expect = 0.0
Identities = 492/1213 (40%), Positives = 708/1213 (57%), Gaps = 173/1213 (14%)
Query: 4 IYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDL 63
+Y +CP CGG + + + EK+ C F + +L L ED
Sbjct: 5 VYSNLCPVCGGDLESKEI-EKHVC-----------------FRKKRSLCLFP-----EDF 41
Query: 64 YRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYF 123
+ E + F++ G + Q+ W KRILR +SF+ APTG+GK++FG +S++
Sbjct: 42 L-----LKEFVEFFRKCVG-EPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFL 95
Query: 124 AIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVR--LVYYHGNLKKKEKEEALKRIKD 181
A+KGKR Y++ PT+ LV+Q + I+ E+AGV + YYHG + K+EKE ++ +++
Sbjct: 96 ALKGKRCYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLRN 155
Query: 182 GDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINR 241
F I++T++QFL+ + EL FD IFVDDVDA LKASKN+D+ L LLGF ++ +
Sbjct: 156 --FKIVITTTQFLSKHYREL---GHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTK 210
Query: 242 AWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSAR 301
+W G+ + G L+V++AT +
Sbjct: 211 SWV---------------GEAR-------------------------GCLMVSTATAK-K 229
Query: 302 GDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKG 361
G + +L+R+LL F++GS R +RN+ D + E + ++L KLG GG+I+
Sbjct: 230 GKKAELFRQLLNFDIGSSRITVRNVEDVAVNDESI--STLSSILEKLGTGGIIYARTG-- 285
Query: 362 IEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLI 421
E AEE+ LK+K F++ +V+A K E F GE+D+L+G A YYGT+VRGLDLP I
Sbjct: 286 -EEAEEIYESLKNK-FRIGIVTATKKGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERI 343
Query: 422 RFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQ 481
RFAVF G P FR +++ +I PQ + L L RN+ +
Sbjct: 344 RFAVFVGCPSFRVTIE--------------DIDSLSPQ--------MVKLLAYLYRNVDE 381
Query: 482 YELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEV-- 539
E + L H+ +V E+++++ K+V
Sbjct: 382 IERL-----------LPAVERHIDEV--------------REILKKVMGKERPQAKDVVV 416
Query: 540 -EGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFE 598
EG++ PD+RTYIQ SGRTSRLFAGG+TKG S ++ DD ++ + I R + + E
Sbjct: 417 REGEVIF--PDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIE--RAKLYDIE 472
Query: 599 IKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFG 658
K +E++ E + RE+DE R + R Q DL+K AL IVESP KAR I+ FFG
Sbjct: 473 FKSIDEVDFEKLSRELDESRDRYR-------RRQEFDLIKPALFIVESPTKARQISRFFG 525
Query: 659 QPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDT 718
+PS + + V YE+ + +L + AS GH+ DL+T G+HGVL+ +G+ +VPVY +
Sbjct: 526 KPSVKVLDGAVVYEIPMQKYVLMVTASIGHVVDLITNRGFHGVLV---NGR--FVPVYAS 580
Query: 719 IKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEK 778
IKRCRDCG+QF E + CPKCGS NV ++ ++A+R+LA + + +++GTDPDTEGEK
Sbjct: 581 IKRCRDCGYQFT--EDRESCPKCGSENVDNSRSRIEALRKLAHDAEFVIVGTDPDTEGEK 638
Query: 779 IAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFE 838
IAWD++N+LS +KR EFHEVTR AIL+A++ RD++E+ VKAQ+VRRIEDRWIGF
Sbjct: 639 IAWDLKNLLSGCGA-VKRAEFHEVTRRAILEALESLRDVDENLVKAQVVRRIEDRWIGFV 697
Query: 839 LSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGE 898
LSQKLWE F NRNLSAGR QTPVLGWI+ R++E E + + + +E+ +
Sbjct: 698 LSQKLWERFNNRNLSAGRAQTPVLGWIIDRFQESRERRK----IAIVRDFDLVLEH---D 750
Query: 899 VKEVEVKDVVIEERE--INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYH 956
+E ++ ++EERE PLPPYTT+ ML DA+R L FS +TMQ+AQ+LFE GL TYH
Sbjct: 751 EEEFDLTIKLVEEREELRTPLPPYTTETMLSDANRILKFSVKQTMQIAQELFENGLITYH 810
Query: 957 RTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDG 1016
RTDS VS+ G IAKEY+ ++ F R+WGE GAHE IRPTRP+ + +LI++G
Sbjct: 811 RTDSTRVSDVGQRIAKEYLGDD-----FVGREWGESGAHECIRPTRPLTRDDVQRLIQEG 865
Query: 1017 IITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGW 1076
++ + L +HF LYDLIFRRF+ASQ +P +V+ +K I E E + +
Sbjct: 866 VLVV-EGLRWEHFALYDLIFRRFMASQCRPFKVVVKKYSIEFDGKTAEEERIVRAEGRAY 924
Query: 1077 SRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIV 1136
+ + +K +L G E+K PKV +TQ ++I +MKERGIGRPSTYA IV
Sbjct: 925 ELYRAVWVKN--ELPTGTFRVKAEVKS--VPKVLPFTQSEIIQMMKERGIGRPSTYATIV 980
Query: 1137 QTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKAD 1196
L R YV+E GR ++PT+ GI V+++LV +Y VSE+RTR LE MD IE + D
Sbjct: 981 DRLFMRNYVVEKYGR--MIPTKLGIDVFRFLVRRYAKFVSEDRTRDLESRMDAIERGELD 1038
Query: 1197 YQEVLRELHEEIK 1209
Y + L +L+ EIK
Sbjct: 1039 YLKALEDLYAEIK 1051
>pir||C72409 reverse gyrase - Thermotoga maritima (strain MSB8)
>gi|2738604|gb|AAC01563.1| (AF013268) reverse gyrase
[Thermotoga maritima]
>gi|4980668|gb|AAD35266.1|AE001702_6 (AE001702) reverse
gyrase [Thermotoga maritima]
Length = 1104
Score = 810 bits (2070), Expect = 0.0
Identities = 485/1209 (40%), Positives = 704/1209 (58%), Gaps = 121/1209 (10%)
Query: 5 YRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLY 64
Y C NCGG TDER PCE CL E ++ Y AL R TLK++ +
Sbjct: 7 YHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYR--------ALLERKTLKEYRFYH 58
Query: 65 RLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFA 124
E + FK+ G QR W KRI++GKSF+++APTG+GK+TFG +++ A
Sbjct: 59 EFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLA 118
Query: 125 IKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDF 184
KGK+S +V PT LV QT++++Q + + V++ ++ ++KK+EKE+ K ++ D+
Sbjct: 119 RKGKKSALVFPTVTLVKQTLERLQKLADE---KVKIFGFYSSMKKEEKEKFEKSFEEDDY 175
Query: 185 DILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWE 244
ILV S+QF++ E L KRFD +FVDDVDA LKAS+NID L+++G +E+I +A+
Sbjct: 176 HILVFSTQFVSKN-REKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFS 234
Query: 245 VIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNI--GILIVASATGSARG 302
IK QGK Y R N+ GIL+V+SAT RG
Sbjct: 235 TIK-----------QGKI-------------------YERPKNLKPGILVVSSATAKPRG 264
Query: 303 DRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGI 362
R L+R+LL F VG SV RNI I RS E+ VE LL G LIF +
Sbjct: 265 IRPLLFRDLLNFTVGRLVSVARNITHVRI-SSRSKEKLVE-LLEIFRDGILIFAQTE--- 319
Query: 363 EFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIR 422
E +EL YLK F V ++ ++ E F+ G+++ L+GV YYG + RG+DLP I+
Sbjct: 320 EEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIK 379
Query: 423 FAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQY 482
+ +F G P RFS++L++ + + ++ E+ QE + E +R I +
Sbjct: 380 YVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEE---------LRKIAKE 430
Query: 483 ELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGK 542
L + E F V ++F+ V ++DE+
Sbjct: 431 HLTQKE-----------FVEKVKEMFRGVV------VKDED------------------- 454
Query: 543 LYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKF 602
L + IPDV TYIQASGR+SR+ G + KG+SVI +D+++F L ++ E EI +
Sbjct: 455 LELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLL-IAEEEIIEE 513
Query: 603 EEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSK 662
E N + ++ E++E R++ ++ D +S L+IVESP KA T++ F G+ S
Sbjct: 514 AEANWKELVHEVEESRRRSE--------RELTDTSRSLLIIVESPTKAETLSRFLGRASS 565
Query: 663 RRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRC 722
R+ ++ +E G+ ++ A+ GH++DLVT G HGV +++GK +VPVY+++KRC
Sbjct: 566 RKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVE--EENGK--FVPVYNSLKRC 621
Query: 723 RDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWD 782
RDCG+QF E + CP C S+N+ D E ++A+RE++LE DEIL+ TDPD EGEKI+WD
Sbjct: 622 RDCGYQFT--EDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWD 679
Query: 783 IRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQK 842
+ L P T +++RIE HE+TR KA + R ++ + VKAQ+VRR++DRWIGFELS K
Sbjct: 680 VTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGK 739
Query: 843 LWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIEN--AKGEVK 900
L + F NLSAGRVQ+ VLGWIV+R +E+ +SE DF L LENG+++ +E A V
Sbjct: 740 LQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVT 799
Query: 901 EVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS 960
VE+++ E E NPLPPYTT + L + S+ L + M + QDLFE G TYHRTDS
Sbjct: 800 VVELQEA---EEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDS 856
Query: 961 IHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
+S G +A+ Y+ + E+ F R W EGAHEAIRP +PID L ++I +G+I
Sbjct: 857 TRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIA- 915
Query: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVK 1080
+LTK H R+Y+LIF RF+ASQ +V + + + +E +EIL DGW+
Sbjct: 916 --DLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFV 973
Query: 1081 PLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLL 1140
PL + P+ E + K+ E K ++ V L+TQ ++ MK+RGIGRPSTYAKIV+ L
Sbjct: 974 PLTVS--PRFEH-RTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLF 1030
Query: 1141 QRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEV 1200
+RGYV E K K++ PT G+ VY YL +Y+ V+EE TR+LE+IMD++E + DYQ
Sbjct: 1031 RRGYVYEDK-YKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQAT 1089
Query: 1201 LRELHEEIK 1209
LR L+EEIK
Sbjct: 1090 LRLLYEEIK 1098
>pir||G72614 probable reverse gyrase APE1376 - Aeropyrum pernix (strain K1)
>gi|5105059|dbj|BAA80373.1| (AP000061) 1222aa long
hypothetical reverse gyrase [Aeropyrum pernix]
Length = 1222
Score = 788 bits (2013), Expect = 0.0
Identities = 474/1219 (38%), Positives = 692/1219 (55%), Gaps = 52/1219 (4%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW 60
+ A+Y G+C NCGG I ++RL + PC CL P + V ALK GTL +
Sbjct: 12 VNAVYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPR----RATPLTVYRALKKAGTLGAY 67
Query: 61 EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS 120
Y +EV E F +G R WSAQR+W KR+++G SF+IIAPTG+GKST +
Sbjct: 68 SWEYLSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYA 127
Query: 121 IYFA-IKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRI 179
Y A +K R +VPT LV Q K+ + G+ Y+ + K +E +L++I
Sbjct: 128 AYVAAVKRGRVLYLVPTENLVRQVYAKLDQV--EPGIATA---YYSRMPAKARESSLEKI 182
Query: 180 KDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVI 239
G ++V ++ FL+ RFD L +FDL VDDVD+ L+ S+N++R LLL GF++E +
Sbjct: 183 ASGGARLIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEETV 242
Query: 240 NRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGS 299
A ++K + +L + L + E V L +EI ++E + E + G L++ASATG
Sbjct: 243 EAAHSLVKARLKLYRALHSGASESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASATGR 302
Query: 300 ARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPID 359
RG + L++ELLGFEVG G LRNIVD Y++ + E ++ LG G ++FV
Sbjct: 303 PRGVKHLLFKELLGFEVGGGSDYLRNIVDAYVVDSDPVGRTAE-IVSALGDGVIVFVSQR 361
Query: 360 KGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPH 419
G + A + L+ G L +R +E F RGE L+G+A+ YG IVRGLDLP
Sbjct: 362 LGKDVARAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLDLPE 421
Query: 420 LIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREE-GEKLYARLRRLIRN 478
++AVF G P + + + R+L +S + QEK E + + RL RL+
Sbjct: 422 RSKYAVFLGAPSAKTHLLEALYSPRRMLAFLS-----IAQEKGVEWAGEAFRRLSRLLEK 476
Query: 479 IPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKE 538
+ ++ + A +E +G + + L + L E ++ + +
Sbjct: 477 VIDTSIVSL--AARGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGLVVD 534
Query: 539 VEGKL-YIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEF 597
G + Y+ +PD TYIQASGR SRL+ G +T+GLS+++ + + L +++W
Sbjct: 535 ARGPIPYLVVPDAPTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWT-TSS 593
Query: 598 EIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFF 657
++ E+++E + REI+E R+ GK +V+ VK+ L++VESP KARTIA F+
Sbjct: 594 RLRPLSEVDMEKLRREIEESRR-------GK-GRRVR--VKTTLLVVESPTKARTIAWFW 643
Query: 658 GQPSKRRIGELVAYEVSIGDK------MLTILASGGHMFDLVTTEGYHGVLILKDDGKPY 711
G+P KRRIG V YE S+ D +L I ++ GH+ DL TT+ + +DG Y
Sbjct: 644 GRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDL-TTDSVGSKYGVDEDGGGY 702
Query: 712 YVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTD 771
Y TIKRC DCG Q CP+CGS D+ V+ +R+LA EVDEI+I TD
Sbjct: 703 RA-YYSTIKRCLDCGAQHTS--SSPFCPRCGSPRQVDSKSVVEILRKLASEVDEIVIATD 759
Query: 772 PDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIE 831
PD EGEKIAWD+ + PY PN++R FHEVT A+++A++ + + ++AQ VRRI
Sbjct: 760 PDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRSGESVEKSLIEAQKVRRIV 819
Query: 832 DRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENG---- 887
DRWIGF LS L F L AGRVQTPVLGWIV RY+E+ ++ + L +G
Sbjct: 820 DRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGGRTS 879
Query: 888 ----ISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQL 943
+ +EN K V+ +EV D+ + E NP PPYTTD L DASR LG SA M++
Sbjct: 880 YFTQNRLEVENLK-RVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKI 938
Query: 944 AQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRP 1003
AQDLFE GL TYHRTDS VS TG+++A EY++ E PR WGE GAHEAIRP RP
Sbjct: 939 AQDLFESGLITYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRP 998
Query: 1004 IDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDV 1063
ID L + + G I +P LT+ H R+YD+IFRRFIASQMKPA + +A +
Sbjct: 999 IDAQDLERAVLSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVF 1058
Query: 1064 EVEGYIEILYDGWSRVKPLPLKQ-IPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMK 1122
G + G++ V P +++ + +L G ++ V ++ ++ LY GD++ +M+
Sbjct: 1059 NHAGVARV-RGGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMR 1117
Query: 1123 ERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQ 1182
E GIGRPSTYAK ++ + GYVIE+K + L+PT+ G+ +Y YL + +K LVS + TR+
Sbjct: 1118 EHGIGRPSTYAKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRR 1177
Query: 1183 LEKIMDEIEEAKADYQEVL 1201
LE+ ++ +E+ + VL
Sbjct: 1178 LEEALERVEKGVEKPEAVL 1196
>pir||G64488 reverse gyrase (intein-containing) - Methanococcus jannaschii
>gi|1500401|gb|AAB99531.1| (U67592) reverse gyrase,
intein containing (rgy) [Methanococcus jannaschii]
Length = 1613
Score = 736 bits (1880), Expect = 0.0
Identities = 425/961 (44%), Positives = 601/961 (62%), Gaps = 109/961 (11%)
Query: 4 IYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDL 63
IY+ MCPNC G IT ERLA CE CL E +EKL + L+ TLK+ +D
Sbjct: 5 IYKEMCPNCNGEITSERLAI-GVCEKCLKEE---NVFEKLKLCEK--LREEKTLKNLKDY 58
Query: 64 YRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYF 123
+ E E E+ F + GF S Q+ W KR+L+ KSFSI+ PTG+GKS FG +S++
Sbjct: 59 CIIWNEFKEFEE-FVKDLGFELLSIQKMWAKRVLKNKSFSIVVPTGVGKSFFGILMSLFL 117
Query: 124 AIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGD 183
A KGKR YI++PTT LV QT +KI + E+ +N+R+V YH L KEK+E +RI++ D
Sbjct: 118 AKKGKRCYIILPTTLLVKQTYEKISSLTEKNNLNIRVVAYHSELSTKEKKEVKERIENND 177
Query: 184 FDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAW 243
+D+L+T+S +L + +FD +FVDDVDA LKASKNIDR+L LLGF +E+IN A+
Sbjct: 178 YDVLITTSNYLTKNMPKC----KFDFVFVDDVDALLKASKNIDRTLKLLGFDEEIINEAY 233
Query: 244 EVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGD 303
++I L K + K+ A K E L K+I KI+ G LI+ASATG + GD
Sbjct: 234 KIIYLIK-IGKIEDAMKKR---EILKKKISKIKH-----------GCLIIASATGKSYGD 278
Query: 304 RIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIE 363
R+KLYRELL FE+G G + LR++VD Y E +E++ ++ G GG++FV ID G+E
Sbjct: 279 RVKLYRELLDFEIGFGMNKLRDVVDIY--DEEFSKEKILEYIKLFGSGGIVFVSIDYGVE 336
Query: 364 FAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRF 423
A+E+ YL K +L+ +K+K+G + F G++D L+GVA+YYG +VRGLD+P +R+
Sbjct: 337 KAQEIEKYLLENNIKAKLIHSKDKKGFDDFREGKIDVLIGVASYYGVLVRGLDMPERVRY 396
Query: 424 AVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYE 483
A+F G+PKF+ + E + L +E+GE
Sbjct: 397 AIFYGIPKFKIRL--------------KEYINSL----KEKGE----------------- 421
Query: 484 LMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKL 543
L E I +EG + E +R+++ ++ I+ S L++ + +
Sbjct: 422 -------LKEDINIEG----------KTEEEIRQIITEKLKIKNFS------LRKEDDEY 458
Query: 544 YIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFE 603
+ IPDV+TYIQASGRTSR+ G+TKG S+++VD++++F L + M + + E E K+ +
Sbjct: 459 LLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMY-ESEFKRID 517
Query: 604 EINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKR 663
E+NLE ++++IDEDR+K+++ G+ +V DL+KS LM+VESPNKARTIA+FFG+PS R
Sbjct: 518 EVNLEELIKKIDEDREKIKV---GRAKGKVPDLLKSVLMVVESPNKARTIANFFGKPSVR 574
Query: 664 RIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCR 723
+I YEV IGD L I ASGGH+FDLVT EG++GV I + Y+P+Y +IK+
Sbjct: 575 KINNRNVYEVCIGDLNLIITASGGHVFDLVTKEGFYGVKIENN----LYIPIYTSIKKVN 630
Query: 724 DCGHQFVDWEQ-----KGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEK 778
G QF D + K + K N DA EN++ +RE+A EVD I I TD DTEGEK
Sbjct: 631 --GEQFTDQKDLEELIKQLMEKGERVNAMDAKENIEIIREIADEVDAIFIATDIDTEGEK 688
Query: 779 IAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIK-----EARDINEDRVKAQLVRRIEDR 833
I +DI P+ NI R+ F+E+T+ AILKA++ E ++E++VK Q+VRRIEDR
Sbjct: 689 IGYDIAINALPFNRNIYRVGFNEITKRAILKAVESFKKGEELSLDENKVKGQVVRRIEDR 748
Query: 834 WIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISI-TI 892
WIGF LSQKLWEVF LSAGRVQTPVLGWI++RY E + + +L L LEN I I I
Sbjct: 749 WIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNEH-KIKVPYLSLKLENDIYIGKI 807
Query: 893 ENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGL 952
+ + EVEV +V + E+EI PLPP+TTD +L++A++ G S + M +AQ+LFELGL
Sbjct: 808 WEDEFDKDEVEV-EVKVYEKEIPPLPPFTTDTLLEEATKRFGLSTDEIMSIAQELFELGL 866
Query: 953 C 953
C
Sbjct: 867 C 867
Score = 275 bits (696), Expect = 2e-72
Identities = 138/256 (53%), Positives = 188/256 (72%), Gaps = 7/256 (2%)
Query: 953 CTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQL 1012
CTYHRT S VS G+ +A+EY+ E+Y R++ EGAHE IRPT+P++T LI+
Sbjct: 1361 CTYHRTSSTRVSLDGMRVAREYLKLNNLEDYLKNREYFMEGAHECIRPTKPMNTDELIEF 1420
Query: 1013 IRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL 1072
+++ I LTK+H ++YDLIFRRFIASQMK A V YE+ I D +VEGY++I
Sbjct: 1421 LKENNI----KLTKNHIKVYDLIFRRFIASQMKEAVVEYEEIYIKDL--DEKVEGYVDIK 1474
Query: 1073 YDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTY 1132
+DGWSR+ L LK++P++EK LKV + K + PKV LY +G+V+ LMKERGIGRPSTY
Sbjct: 1475 FDGWSRIYNLKLKKLPRIEKSS-LKVLDKKLRKIPKVPLYDEGEVVKLMKERGIGRPSTY 1533
Query: 1133 AKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEE 1192
A+I++ LL RGYV+++K + KL+PT+ GI+VY YL++ Y L+SEERTR+LE+IMD+IE
Sbjct: 1534 AQIIKKLLDRGYVVKSKDKNKLIPTKLGIEVYNYLINNYPHLISEERTRELEEIMDKIEN 1593
Query: 1193 AKADYQEVLRELHEEI 1208
+ DY EVL+ LHEEI
Sbjct: 1594 GEVDYIEVLKALHEEI 1609
>gb|AAK41237.1| Reverse gyrase (topR-2) [Sulfolobus solfataricus]
Length = 1166
Score = 684 bits (1746), Expect = 0.0
Identities = 444/1237 (35%), Positives = 677/1237 (53%), Gaps = 106/1237 (8%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLS--EPIKAEDYEKLVFAVRNALKLRGTLK 58
+ +Y+ CPNCGG I+ +RL PCE CL I D+ V + N L +K
Sbjct: 2 INVMYKNSCPNCGGDISGDRLLNGLPCEACLPYINGIDDVDHISKVKTLYNILLNNDKIK 61
Query: 59 DWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAF 118
++ +LY V F+ TG+ WS Q+ W++R+ +SF++ APTG+GK+T
Sbjct: 62 NYWNLYYNITTFETVFKYFRDKTGYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTTTLMT 121
Query: 119 ISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKR 178
S++ G+ +VPT L+ Q K++ E+ G V G + +K+
Sbjct: 122 YSVFI---GQDVVYIVPTKSLMEQVCKRL----EKLGAQVSC----GKIDQKK------- 163
Query: 179 IKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEV 238
+ V + +L D ++ K + + +DD DA +K+ K DR + LLG ++V
Sbjct: 164 -------VSVITISYLNKNADSIVSLKP-NFVVIDDADAVIKSGKTTDRLVSLLGIPKDV 215
Query: 239 INRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATG 298
A ++I+L+ + + EE+ ++I ++E +I ++ + I L++ASAT
Sbjct: 216 YESAIQLIRLRNKY------YFSNEYTEEVKEKIRELELKIAEFK--DKISQLVIASATI 267
Query: 299 SARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPI 358
+G + K R L GFE S + RNI+D Y E +++++LG GGLI V
Sbjct: 268 RPKGIKQKALRLLTGFEPSSIQLYARNIIDAYT------ENLDLSIVKELGSGGLILVSK 321
Query: 359 DKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLP 418
+ G E+ Y++ GF +L + ++ L+ F +G+VD LVG A+YYG VRG+D P
Sbjct: 322 EYGRSKLNEIKKYVEDLGFNAKL-AISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEP 380
Query: 419 HLIRFAVFAGVPKFRFSM--DLEQP-TIYRVLGLMSEILEFLPQEKREEGEKLYARLRRL 475
+++ ++ GVPK R + L P T+ RV L+ ++F KL ++ L
Sbjct: 381 KRLKYVIYYGVPKIRAKLFDALSNPFTLLRVGKLIG--IDF---------SKLQNKI--L 427
Query: 476 IRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRD---EEVIRRISENP 532
I N + +L+K E I H L+ +Q + + +++D E+V + +
Sbjct: 428 ILNPSEVQLLKFSIIKGESINY-----HKLEQLRQELLYYMSLVKDKLKEKVEDTLISDS 482
Query: 533 FLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRW 592
F+ K+ G YI PD+ TY+Q SGR SRL+ GG+T G S+I+VDD+ +F L ++M+
Sbjct: 483 FVITKQ-NGNYYIVYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDRHIFEILEKKMQK 541
Query: 593 RFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKART 652
F NL + ++++ RK+ EG +V + + L+IVESP KA+T
Sbjct: 542 LFPNTTFTSLSNTNLSEIKIKLEDSRKE-----EGN---RVHFNISTGLLIVESPTKAKT 593
Query: 653 IASFFGQPSKRRIGELVAYEVSIGDK----MLTILASGGHMFDLVTTE-GYHGVLILKDD 707
IA F +PS R ++ YE I D +L I+AS GH+ DL + GY+G+ + +DD
Sbjct: 594 IAKMFSRPSVRIRNKVPVYETIIVDGNQIYVLDIVASKGHIVDLTLEDIGYYGIKV-EDD 652
Query: 708 G--KPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDE 765
G KPYY D IK+C DC F K CP CGS N+ A + +RELAL VD+
Sbjct: 653 GTIKPYY----DLIKKCLDCNKIFSSASDK--CPYCGSANLQSAQTTINLLRELALSVDK 706
Query: 766 ILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQ 825
+ I +DPDTEGEKIA+D+ + LSPY N+ R+ +HE+T+ AIL+A++ + IN + V +Q
Sbjct: 707 VFIASDPDTEGEKIAYDLASFLSPYNSNVYRVVYHEITKKAILEALRNPKKINTNLVMSQ 766
Query: 826 LVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTES-----ETDFL 880
+VRRIEDRWIGF LS L F N AGRVQTPVLGWIV + ++ + D
Sbjct: 767 IVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVNKTIKYKSAMGHVVYIDIA 826
Query: 881 GLTLENGIS--ITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSAT 938
G +++ S +E ++ ++ + E+ ++PLPP+TTD +L +A+ A
Sbjct: 827 GYSIKKYFSEKRKVEEYINNLQVARIEKISEEKILLSPLPPFTTDTLLIEANMKYKLPAN 886
Query: 939 KTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKW--GEEGAHE 996
M++AQDLFE GL TYHRTDS H+S+ GIEIAKEY+ ++ + F PR W EEGAHE
Sbjct: 887 LVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQALIKEFVPRSWESSEEGAHE 946
Query: 997 AIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAII 1056
AIRPTR ID LIQ I + +K H +YDLIF+RFIASQM A + +I
Sbjct: 947 AIRPTRAIDVNELIQEIEENPYKYSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLI 1006
Query: 1057 STPFGD-VEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQG 1115
D V+VE + G+ +V P+ + +P E K+ +T + L +
Sbjct: 1007 KLGKDDNVDVE-LLSNAEGGFIKVYPVKVYNLPVGEIQPKVNIT-----KGSSEQLLSYS 1060
Query: 1116 DVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLV 1175
DVI+LMK +GIGRPSTYAK ++ L++ GY++ +K + L+ T +GI VYQ+L SK+ DLV
Sbjct: 1061 DVISLMKSKGIGRPSTYAKTIENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLV 1120
Query: 1176 SEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYI 1212
SE T +L +D+I +K + VL E+ EI +
Sbjct: 1121 SESTTSRLMTKLDDIALSKLNASTVLLEIFSEISTLV 1157
>pir||T29099 reverse gyrase - Sulfolobus shibatae >gi|1679872|emb|CAA67064.1|
(X98420) reverse gyrase [Sulfolobus shibatae]
Length = 1166
Score = 671 bits (1712), Expect = 0.0
Identities = 434/1234 (35%), Positives = 662/1234 (53%), Gaps = 100/1234 (8%)
Query: 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLS--EPIKAEDYEKLVFAVRNALKLRGTLK 58
+ +Y+ CPNCGG I+ +RL PCE CL I D+ V A+ N L +K
Sbjct: 2 INVMYKNSCPNCGGDISADRLLNGLPCETCLPYINGIDGIDHISKVKALYNILLDNDKIK 61
Query: 59 DWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAF 118
++ +LY V FK TG+ WS Q+ W++R++ +SF++ APTG+GK+T
Sbjct: 62 NYWNLYYNITTFETVFKYFKDKTGYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMT 121
Query: 119 ISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKR 178
S++ G+ +VPT L+ Q K++ E+ G V G + +++
Sbjct: 122 YSVFI---GQDVVYIVPTKSLMEQVCKRL----EKLGAQVSC----GKVDQRK------- 163
Query: 179 IKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEV 238
+ V + +L D + K + + +DD DA +K+ K DR + LLG +V
Sbjct: 164 -------VSVITISYLNKNADSITSYKP-NFVAIDDADAVIKSGKTTDRLVSLLGIPNDV 215
Query: 239 INRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATG 298
A ++I+L+ + + EE+ ++I ++E +I ++ + I L++ASAT
Sbjct: 216 YESAIQLIRLRNKY------YFSNEFTEEIKEKIRELELKIAEFK--DKISQLVIASATI 267
Query: 299 SARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPI 358
+G + K R L GFE S + RNI+DTY + +++++LG GGLI V
Sbjct: 268 RPKGIKQKALRLLTGFEPSSIQLYARNIIDTYT------DNLDLSIIKELGSGGLILVSK 321
Query: 359 DKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLP 418
+ G E+ Y++ GF +L + ++ L+ F +G+VD LVG A+YYG VRG+D P
Sbjct: 322 EYGRSRLNEIKKYVEDLGFNAKL-AISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEP 380
Query: 419 HLIRFAVFAGVPKFRFSM--DLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLI 476
+++ ++ GVPK + + L P +G M + ++ L+ I
Sbjct: 381 KRLKYVIYYGVPKIKAKLFDALSNPFTLLRVGKMIGVN--------------FSELQNKI 426
Query: 477 RNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSL 536
+ E ++ ++ +G E + L+ +Q + + +++D+ ++ I E +S
Sbjct: 427 LVLSPSEAQLLKFSIIKG---ETINYQKLEQLRQELLYYISLVKDK--LKEIGEETLISD 481
Query: 537 KEVEGK----LYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRW 592
V K YI PD+ TY+Q SGR SRL+ GG+T G S+I+VDD+ +F L ++M+
Sbjct: 482 NFVIAKQNTNYYIIYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDKHIFEILKKKMQK 541
Query: 593 RFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKART 652
F INL + +++E RK+ EG +V + + L+IVESP KA+T
Sbjct: 542 LFPNTNFTSLSNINLSEIKTKLEESRKE-----EGN---RVHFNISTGLLIVESPTKAKT 593
Query: 653 IASFFGQPSKRRIGELVAYEVSIGDK----MLTILASGGHMFDLVTTE-GYHGVLILKDD 707
IA F +PS R I ++ YE I D +L ++AS GH+ DL + GY+G+ I +
Sbjct: 594 IAKMFSRPSVRVINKVPVYETIIVDGNQIYVLDVVASKGHIVDLTLEDIGYYGIKI---E 650
Query: 708 GKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEIL 767
P YD IK+C DC F K CP CGS NV A + +RELAL VD++
Sbjct: 651 YSGIIKPYYDLIKKCLDCNKTFSIASDK--CPYCGSTNVQTAQTTINLLRELALSVDKVF 708
Query: 768 IGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLV 827
I +DPDTEGEKIA+D+ + LSPY NI RI +HE+T+ AIL+A++ IN + V +Q+V
Sbjct: 709 IASDPDTEGEKIAYDLASFLSPYNSNIYRITYHEITKKAILEALRNPMKINTNLVMSQIV 768
Query: 828 RRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTES-----ETDFLGL 882
RRIEDRWIGF LS L F N AGRVQTPVLGWIV + ++ + D G
Sbjct: 769 RRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVDKTIKYKSAMGYVVYIDIAGY 828
Query: 883 TLENGIS--ITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKT 940
++ S +E ++ V+++ + E+ ++PLPP+TTD +L +A+ A
Sbjct: 829 PIKMHFSERKKMEEYINNLQVVKIEKIFEEKILLSPLPPFTTDTLLIEANMKYKLPANLV 888
Query: 941 MQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKW--GEEGAHEAI 998
M++AQDLFE GL TYHRTDS H+S+ GIEIAKEY+ ++ + F PR W EEGAHEAI
Sbjct: 889 MKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQGLIKDFVPRSWESSEEGAHEAI 948
Query: 999 RPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIIST 1058
RPTR ID LIQ I + +K HF +YDLIFRRF+ASQM A + +I
Sbjct: 949 RPTRAIDVNELIQEIEENPYKYSIRFSKLHFLIYDLIFRRFMASQMSHAVGTKSRYLIKL 1008
Query: 1059 PFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVI 1118
D + G+ +V P+ + +P E K + + L + DVI
Sbjct: 1009 NKNDNINAELLSNAEGGFIKVYPVKVYNLPLGEVKPK-----VNTGKGSSEQLLSYSDVI 1063
Query: 1119 ALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEE 1178
+LMK +GIGRPSTYAK ++ L++ GY++ +K + L+ T +GI YQ+L SK+ DLVSE
Sbjct: 1064 SLMKSKGIGRPSTYAKTIENLVRHGYIVSSKRKSYLIATNRGISAYQFLSSKFYDLVSEG 1123
Query: 1179 RTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYI 1212
T +L +D+I +K VL E+ EI +
Sbjct: 1124 TTAKLMSKLDDIALSKLSASTVLLEIFSEISTLV 1157
>pir||T18550 reverse gyrase chain B homolog rgyB - Methanopyrus kandleri
>gi|1173903|gb|AAA96963.1| (U41059) reverse gyrase B
subunit [Methanopyrus kandleri]
Length = 1221
Score = 570 bits (1452), Expect = e-161
Identities = 366/950 (38%), Positives = 538/950 (56%), Gaps = 112/950 (11%)
Query: 3 AIYRGMCPNCGGAITDERLAEK-NPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWE 61
AI+ C CGG + RL + CE CL P+ D E L ++ A K G + +
Sbjct: 60 AIFGSSCVLCGGDCSSVRLTSRIGICERCL--PV---DTETLREVLKEARKRHGYVGEAL 114
Query: 62 DLYRLNKEVSE-------------------VEDLFKRATGFRFWSAQRTWVKRILRGKSF 102
++ L + S V+ +F RATGFR +SAQR W +R+++G SF
Sbjct: 115 LMFILVERYSPDRVEEFFRRYVWPELFTEIVDRVFDRATGFRLYSAQRVWTRRLVKGCSF 174
Query: 103 SIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVY 162
SI+APTG GK+++G+ ++ F G+R Y +VPTT LV Q +I+ A ++V +V
Sbjct: 175 SILAPTGTGKTSWGSLVAAVFGHAGRRVYYLVPTTTLVRQVENRIKGFARDAELDVDVVA 234
Query: 163 YHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKAS 222
YH + + K EAL+RI GDFD+L+T++QFL R ++ L FDLI VDDVDA ++ +
Sbjct: 235 YHAAMPTQAKREALERISSGDFDVLITTAQFLVHRVED-LEKLNFDLILVDDVDAIIRGT 293
Query: 223 -KNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKL------------LQAQGKEKEVEELN 269
+N+DR L + G QE I+ A+ + L+++ L +A+ +E+ E+
Sbjct: 294 GRNVDRVLRVAGLEQEEIDSAYRLATLRRRYYSLRDWLRSLEDRGDKRAERVREELREVE 353
Query: 270 KEIEKIEREIERYRRENNIGILIVASATGSAR-GDRIKLYRELLGFEVGSGRSVLRNIVD 328
+EIE++E ++R ++E ++ ++ SATG+A R+ + REL FEVG+G LRNI D
Sbjct: 354 REIEELEELLKRVKKERDLARIVFMSATGAAAPSRRLAVVRELFDFEVGAGGEGLRNIQD 413
Query: 329 TYIIPERSIEEEVENLLRKLG-KGGLIFVP-----IDKGIEFAEELTNYLKSKGFKVELV 382
+I E S E VE ++RK G KGGLIFVP K E EEL +L+S G + +
Sbjct: 414 IAVISEPS-PEAVERIVRKAGVKGGLIFVPQRLPGEKKAREIVEELAEHLRSSGIEARAI 472
Query: 383 SA-----KNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSM- 436
A + + ++ F G+VD LV VA+ YG IVRGLDLP R+AVF GVP+ R +
Sbjct: 473 HAGTPAEEREEAIDGFSEGDVDVLVAVASPYGVIVRGLDLPQAARYAVFYGVPRQRIRLT 532
Query: 437 ----DLEQPTIYRVLGLMSEILEFLPQEK-REEGEKLYARLRRLIRN------------- 478
DL+ PT V +S + L + R E + RL R+IR
Sbjct: 533 PREEDLKDPTY--VASALSNLARLLDDRRARSRLEGVAGRLWRIIRRGTWIRERLEEAVE 590
Query: 479 -IPQYELMKI----EEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPF 533
+ LMK+ E +AE ++++ + + + V L +L D + ++ ++E
Sbjct: 591 PLSLNTLMKLAKRDPEDIAEQLDVDRWLARHVQTLAEGVRELTRLLGDPDRVKALAEEAT 650
Query: 534 LSLKEVEG-KLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQ----KVFNGLIR 588
EG + Y+E+PD+RTYIQASGR SRLFAGG+T GLS ++ + + NGLIR
Sbjct: 651 TVAVYEEGEEAYLEVPDLRTYIQASGRVSRLFAGGVTFGLSFVLCPEDERELRTLNGLIR 710
Query: 589 QMRWRF-----------------VEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKIS- 630
+M + + + E+K+ + LE ++R++DEDR++VR V+ G++
Sbjct: 711 RMSYTYGSEFEWRSYPKSLDMKEIGLELKEISDEELEELVRKVDEDRERVRKVLAGELKP 770
Query: 631 EQVKDLVKSALMIVESPNKARTIASFFGQ-PSKRRIGELVAYEVSIGDKMLTILASGGHM 689
E+ L +SALMIVESPNKAR IAS F Q PS+RR+ VAYE + LT++A+ GH+
Sbjct: 771 EETGRLARSALMIVESPNKARMIASLFSQRPSRRRLNGGVAYEAAADGLHLTVVATQGHV 830
Query: 690 FDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDA 749
DLV G HGVL + + +VP+YD + RC +CG Q V E+ CP CG V
Sbjct: 831 ADLVEEPGVHGVLRIDE----RWVPMYDVLGRCSECGEQVVGSEE---CPNCGG-EVELK 882
Query: 750 LENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILK 809
++++RELA E D ILIGTDPDTEGEKI WD+ N L T + R EFHEVTR I +
Sbjct: 883 TPLLESIRELASEADVILIGTDPDTEGEKIGWDVFNYLGWTTAQVYRTEFHEVTRRGISE 942
Query: 810 AIKEA--RDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRV 857
A+KE ++++ RV AQ++RR+ DRWIGF LSQ LW+VF++ + G +
Sbjct: 943 ALKEESWKNVDAGRVSAQILRRVADRWIGFSLSQDLWDVFKHLEIKLGEL 992
>gb|AAA96962.1| (U41058) reverse gyrase A subunit [Methanopyrus kandleri]
Length = 358
Score = 277 bits (700), Expect = 7e-73
Identities = 150/338 (44%), Positives = 213/338 (62%), Gaps = 21/338 (6%)
Query: 891 TIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFEL 950
++ AK EV VE EEREI+P PP+ T MLQ A+R L S+ + MQLAQDLFE
Sbjct: 19 SLRGAKAEVVRVER-----EEREIHPKPPFETGTMLQAATRRLRLSSERVMQLAQDLFEG 73
Query: 951 GLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEE-----GAHEAIRPTRPID 1005
GL TYHRTDS VS G + ++YI E + PR W E GAHE IRPTRP D
Sbjct: 74 GLITYHRTDSTRVSEEGKRVRRDYIRANFDPEDYNPRTWEPEAEHVEGAHECIRPTRPAD 133
Query: 1006 TGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIIST-----PF 1060
L ++R+G I LT H RLYDL+FRRF+ASQMKPA+VLY++A++ P
Sbjct: 134 AEELRTMVREGAIQTTVTLTSHHLRLYDLVFRRFVASQMKPAKVLYQEAVLEVEVKGVPV 193
Query: 1061 GDVEVEGYIEILYDGWSRVKP---LP---LKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQ 1114
++E+ G +EI+ G+++V LP +++ P+LE+G +L++ ++ + Y Q
Sbjct: 194 AELELSGVLEIVEPGFTKVLTEYDLPAYGIRETPELEEGDRLEIGAVEVLERHEEYPYDQ 253
Query: 1115 GDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDL 1174
+++ M+ERG+GRPSTYA+IV+ L +RGYV E R+ + PT +G VY+YL + Y+
Sbjct: 254 SELVEDMRERGLGRPSTYAQIVEKLFRRGYVYEVPQRRWIFPTTRGEAVYEYLSTHYERF 313
Query: 1175 VSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYI 1212
VSEE TR LE+ MD + KA+YQE + +L+ E++R +
Sbjct: 314 VSEETTRDLEERMDAVALGKAEYQEEMEKLYLELERVV 351
>pir||B81266 DNA topoisomerase (EC 5.99.1.2) I Cj1686c [imported] - Campylobacter
jejuni (strain NCTC 11168) >gi|6969101|emb|CAB73672.1|
(AL139079) DNA topoisomerase I [Campylobacter jejuni]
Length = 700
Score = 259 bits (655), Expect = 1e-67
Identities = 198/621 (31%), Positives = 296/621 (46%), Gaps = 113/621 (18%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
+K L+IVESP KA+TI +F G+ YEV +AS GH+ DL +
Sbjct: 1 MKKNLIIVESPAKAKTIGNFLGKD----------YEV---------IASKGHIRDLPKSS 41
Query: 697 GYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAM 756
G+ I D+ P Y D H AL VK +
Sbjct: 42 --FGIKIEDDEFIPEYRITSD-----------------------------HSAL--VKEL 68
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARD 816
+ A + E+ + TD D EGE IA+ I + + RI FHE+T+ AI A+K R
Sbjct: 69 KSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRK 128
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYK------ 870
+N V AQ RR+ DR +G++LS L + + R LSAGRVQ+ L IV R K
Sbjct: 129 LNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQ-RGLSAGRVQSAALKIIVDREKEIRAFV 187
Query: 871 --------------------EFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIE 910
EF +++ + L +T ++ + +E K EV + D+ +
Sbjct: 188 PLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEV--YSISDIESK 245
Query: 911 EREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTDSIH 962
ER+I P PP+ T + Q AS LGF+ KTM +AQ L+E +G+ TY RTDS++
Sbjct: 246 ERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLN 305
Query: 963 VSNTGIEIAKEYISEEIGEEY-------FAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRD 1015
++ +E A+++I G++Y + + G + AHEAIRPT T +
Sbjct: 306 LAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEI------ 359
Query: 1016 GIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDG 1075
+ L KD +LY LI+ RF+A QM PA + + ++ G +IL+DG
Sbjct: 360 ----AAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGR-KILFDG 414
Query: 1076 WSRVKPLPLKQ--IPKLEKGQKLKV--TEIKQWRAPKVSLYTQGDVIALMKERGIGRPST 1131
+ +V K +P + GQ LKV E+ S Y++ ++ ++ GIGRPST
Sbjct: 415 YYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPST 474
Query: 1132 YAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIE 1191
YA + L R YV T +K+L+P++ V + L + D+V + T LE +DEI
Sbjct: 475 YAPTISILTSRDYV--TIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIA 532
Query: 1192 EAKADYQEVLRELHEEIKRYI 1212
E KAD+QE L+E + R I
Sbjct: 533 EDKADWQETLKEFYYPFMRKI 553
>sp|O66893|TOP1_AQUAE DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7521740|pir||A70358 topoisomerase
I - Aquifex aeolicus >gi|2983253|gb|AAC06848.1|
(AE000700) topoisomerase I [Aquifex aeolicus]
Length = 540
Score = 254 bits (641), Expect = 6e-66
Identities = 200/601 (33%), Positives = 308/601 (50%), Gaps = 105/601 (17%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L IVESP KA+TI F G K + A+ GH+ DL E G
Sbjct: 3 LFIVESPTKAKTIQKFLG-------------------KGFLVKATLGHVKDLPEKE--LG 41
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
V + K Y K G + + V+ +++L+
Sbjct: 42 VDLRTLKAKYVY---------------------------KRGKKKL------VEQLKKLS 68
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINED 820
+ +GTDPD EGE IA+ ++ L NIKR F+E+T AI ++I+ A D+N +
Sbjct: 69 RRSSIVYLGTDPDREGEAIAYFLKKDLEKVNKNIKRAVFYEITPEAIRESIRNAGDVNMN 128
Query: 821 RVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE---FTESET 877
V AQ RRI DR IG+ +S LW+ F+N LSAGRVQ+P L IV+R +E F +
Sbjct: 129 LVYAQFARRILDRLIGYLISPILWKEFKNYKLSAGRVQSPALRLIVEREREIQNFKVKKY 188
Query: 878 DFLGLTLENG-------ISITIEN---AKGEVKEVE-----VKDVVIEEREINPLPPYTT 922
++ L G EN AK K++E V V ++ +++P P+ T
Sbjct: 189 YYVKALLRKGSEEFWAIYDYRYENPSDAKIIAKKLEKGYFSVYKVEKKKEKVSPPKPFIT 248
Query: 923 DAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEE 982
+ +A+ GFS+ +T +LAQ+L+E G TY RTDS ++ + YI ++ G+E
Sbjct: 249 SDLQSEANAKFGFSSERTQKLAQELYEKGYITYPRTDSYRMNEKKAKEFMNYIEKKYGKE 308
Query: 983 YFAP-RKWGE----EGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFR-LYDLIF 1036
Y R++ E +GAHE IRPT +R+ I ++ R LYDLIF
Sbjct: 309 YVGRLRRFREKATAQGAHECIRPTS----------LREEI------PEREELRLLYDLIF 352
Query: 1037 RRFIASQMKPARVLYEKAIISTPFGDVEVEGY-----IEILYDGWSRVKPLPL--KQIPK 1089
RR IAS MK + EK + +++ Y ++I++DGWSRV P + +++P+
Sbjct: 353 RRTIASLMKEMLLEREKVTVEAITPELKHPVYLVAKGLKIVFDGWSRVYPSEITEEKLPE 412
Query: 1090 LEKGQKLKV--TEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIE 1147
L +G L + T +++ + YT+G +I +++ GIGRPSTYA IV+TL +RGYV E
Sbjct: 413 LYEGDLLDLVKTTLEERKTQPPPRYTEGTLIKTLEKLGIGRPSTYATIVKTLKERGYV-E 471
Query: 1148 TKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEE 1207
K +K LVPTE +V ++L+ ++ L+ + T Q+E+ +D +EE K +++ V+ E E+
Sbjct: 472 VK-KKALVPTEIAFQVVEFLMERFPTLMDYKFTAQMEEKLDLVEEGKLNWKSVVYEFMEK 530
Query: 1208 I 1208
I
Sbjct: 531 I 531
>sp|P46799|TOP1_THEMA DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|2120369|pir||S62737 DNA
topoisomerase I - Thermotoga maritima (strain MSB8)
>gi|881494|gb|AAA68949.1| (U27841) topoisomerase I
[Thermotoga maritima]
>gi|4980754|gb|AAD35346.1|AE001708_14 (AE001708) DNA
topoisomerase [Thermotoga maritima]
Length = 633
Score = 253 bits (639), Expect = 1e-65
Identities = 200/598 (33%), Positives = 300/598 (49%), Gaps = 102/598 (17%)
Query: 642 MIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGV 701
++VESP KA+TI S G YEV AS GH+ DL ++ GV
Sbjct: 9 IVVESPAKAKTIKSILGN----------EYEV---------FASMGHIIDLPKSK--FGV 47
Query: 702 LILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELAL 761
+ KD + P + IK G V V+ +++LA
Sbjct: 48 DLEKD-----FEPEFAVIK---------------------GKEKV------VEKLKDLA- 74
Query: 762 EVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDR 821
+ E+LI +D D EGE IAW I V + RI F E+T I +A+K R+I+ +
Sbjct: 75 KKGELLIASDMDREGEAIAWHIARVTNTLGRK-NRIVFSEITPRVIREAVKNPREIDMKK 133
Query: 822 VKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE--------FT 873
V+AQL RRI DR +G+ LS LW F++ NLSAGRVQ+ L + R +E +
Sbjct: 134 VRAQLARRILDRIVGYSLSPVLWRNFKS-NLSAGRVQSATLKLVCDREREILRFVPKKYH 192
Query: 874 ESETDFLGLTLENGISITIENAKGEVKEVE-VKDVVIEEREIN-----PLPPYTTDAMLQ 927
+F GLT E + +KE++ + ++V+EE++++ P P+ T + Q
Sbjct: 193 RITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQ 252
Query: 928 DASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTDSIHVSNTGIEIAKEYISEEI 979
+A LGFS +KTM +AQ L+E + TY RTDS VS+ E A+ I+E
Sbjct: 253 EAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVF 312
Query: 980 GEEYFAPRKWGE------EGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYD 1033
GEEY ++ + AHEAIRPT T + L D +LY+
Sbjct: 313 GEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPE----------EAGKYLNSDQKKLYE 362
Query: 1034 LIFRRFIASQMKPARVLYEKAIISTPFGDVEVEG-YIEILYDGWSRVKPLPLK--QIPKL 1090
LI++RF+ASQMKP++ + ++ T G +G ++ ++DG+ +V + P
Sbjct: 363 LIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFP-F 421
Query: 1091 EKGQKLK--VTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIET 1148
E+G+ +K V +I++ YT+G ++ M+ GIGRPSTYA ++ LL RGY+ +
Sbjct: 422 EEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKI 481
Query: 1149 KGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHE 1206
+G L PT G V YL KY D+VS T ++EK +DE+E+ K + VLRE +E
Sbjct: 482 RG--YLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYE 537
>sp|Q9KA23|TOP1_BACHD DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|10175087|dbj|BAB06186.1|
(AP001515) DNA topoisomerase I [Bacillus halodurans]
Length = 690
Score = 242 bits (612), Expect = 1e-62
Identities = 189/623 (30%), Positives = 297/623 (47%), Gaps = 118/623 (18%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI + G K T+ AS GH+ DL ++ G
Sbjct: 5 LVIVESPAKAKTIGKYLG-------------------KKYTVKASMGHVRDLPKSQ--MG 43
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
V I +D+ P Y+ + +G P +K ++ A
Sbjct: 44 VDI-EDEYSPRYITI-------------------RGKGPV------------LKELKSAA 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINED 820
+V + + DPD EGE IAW + + L + R+ F+E+T+ AI A K R IN D
Sbjct: 72 KKVKRVYLAADPDREGEAIAWHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMD 131
Query: 821 RVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETD-- 878
V AQ RR+ DR +G+ +S LW+ + + LSAGRVQ+ + I+ R KE E +
Sbjct: 132 LVDAQQARRVLDRLVGYNISPLLWKKVK-KGLSAGRVQSVAVKMIIDREKEIQAFEPEEY 190
Query: 879 -----------------FLG-------LTLENGISITIENAKGEVKEVEVKDVVIEEREI 914
F G L E+ ++ + KG+ + V V +ER+
Sbjct: 191 WSIQGTFALDGEPFEAKFYGTNGKKVELKSEDDVNNVLAKLKGD--QFHVDSVQKKERKR 248
Query: 915 NPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE---------LGLCTYHRTDSIHVSN 965
NP+ P+TT ++ Q+A+R L F A KTM LAQ L+E +GL TY RTDS +S+
Sbjct: 249 NPVSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISD 308
Query: 966 TGIEIAKEYISEEIGEEY------FAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIIT 1019
T KEYI + G+EY + + AHEAIRPT + +
Sbjct: 309 TAKAETKEYIESKFGKEYAQNGTKAVKKDKKSQDAHEAIRPTS----------VERDPKS 358
Query: 1020 LPRNLTKDHFRLYDLIFRRFIASQMKPARV------LYEKAIISTPFGD-VEVEGYIEIL 1072
L L++D RLY LI+ R +ASQM PA + L + ++ G V+ G++++
Sbjct: 359 LKEYLSRDQLRLYKLIWERLVASQMAPAIMDTMTVDLSNEGVLFRATGSKVKFPGFMKVY 418
Query: 1073 YDGWSRVKPLPLKQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKERGIGRPS 1130
+G K + +P L++GQ + EI+ Q YT+ ++ M+E GIGRPS
Sbjct: 419 IEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELGIGRPS 478
Query: 1131 TYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEI 1190
TYA + T+ +RGYV ++ VPTE G V + + + +++ E T ++E +D I
Sbjct: 479 TYAPTLDTIQKRGYV--ALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDLDSI 536
Query: 1191 EEAKADYQEVLRELHEEIKRYIR 1213
EE K + +++ + ++ + ++
Sbjct: 537 EEGKQQWIKIIDDFYKGFEERLK 559
>sp|P39814|TOP1_BACSU DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7449002|pir||G69724 DNA
topoisomerase I topA - Bacillus subtilis
>gi|520753|gb|AAA22763.1| (L27797) DNA topoisomerase I
[Bacillus subtilis] >gi|2462970|emb|CAA04422.1|
(AJ000975) DNA Topoisomerase I [Bacillus subtilis]
>gi|2633984|emb|CAB13485.1| (Z99112) DNA topoisomerase I
[Bacillus subtilis]
Length = 691
Score = 241 bits (609), Expect = 3e-62
Identities = 188/626 (30%), Positives = 304/626 (48%), Gaps = 124/626 (19%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI + G+ K + AS GH+ DL ++
Sbjct: 5 LVIVESPAKAKTIERYLGKKYK-------------------VKASMGHVRDLPKSQ---- 41
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
+ D + + P Y TI+ KG +K ++ A
Sbjct: 42 ---MGVDIEQNFEPKYITIRG-------------KGPV--------------LKELKTAA 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINED 820
+ ++ + DPD EGE IAW + + L + R+ F+E+T+ AI ++ K R IN D
Sbjct: 72 KKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMD 131
Query: 821 RVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTE------ 874
V AQ RRI DR +G+++S LW+ + + LSAGRVQ+ L I+ R KE +
Sbjct: 132 LVDAQQARRILDRLVGYKISPILWKKVK-KGLSAGRVQSVALRLIIDREKEINDFKPEEY 190
Query: 875 -------------SETDFLGLTLENGISITIENAKGEVKEV---------EVKDVVIEER 912
E F G +NG + + N++ +VKE+ V+ V +ER
Sbjct: 191 WTIDGTFLKGQETFEASFFG---KNGKKLPL-NSEADVKEILSQLKGNQYTVEKVTKKER 246
Query: 913 EINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE---------LGLCTYHRTDSIHV 963
+ NP P+TT + Q+A+R L F A KTM +AQ L+E +GL TY RTDS +
Sbjct: 247 KRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRTDSTRI 306
Query: 964 SNTGIEIAKEYISEEIGEEYFA----PRKWGE--EGAHEAIRPTRPIDTGRLIQLIRDGI 1017
SNT ++ A +I + G+E+ P K E + AHEAIRPT + ++ +
Sbjct: 307 SNTAVDEAAAFIDQTYGKEFLGGKRKPAKKNENAQDAHEAIRPTSVLRKPSELKAV---- 362
Query: 1018 ITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFG--------DVEVEGYI 1069
L +D RLY LI+ RF+ASQM PA VL ++ T G V+ G++
Sbjct: 363 ------LGRDQMRLYKLIWERFVASQMAPA-VLDTMSVDLTNNGLTFRANGSKVKFSGFM 415
Query: 1070 EILYDGWSRVKPLPLKQIPKLEKGQKL--KVTEIKQWRAPKVSLYTQGDVIALMKERGIG 1127
++ +G + +P L++G + K E +Q YT+ ++ ++ERGIG
Sbjct: 416 KVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEERGIG 475
Query: 1128 RPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIM 1187
RPSTYA + T+ +RGYV K+ VPTE G V ++ + ++++ E T ++E+ +
Sbjct: 476 RPSTYAPTLDTIQRRGYV--ALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMERDL 533
Query: 1188 DEIEEAKADYQEVLRELHEEIKRYIR 1213
D +EE ++ +++ + + ++ ++
Sbjct: 534 DHVEEGNTEWVKIIDNFYTDFEKRVK 559
>sp|O34204|TOP1_FERIS DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|2352095|gb|AAB68788.1| (U97022)
DNA topoisomerase I [Fervidobacterium islandicum]
Length = 699
Score = 239 bits (604), Expect = 1e-61
Identities = 202/641 (31%), Positives = 308/641 (47%), Gaps = 122/641 (19%)
Query: 617 DRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIG 676
D + + ++G+ + K ++IVESP KA+TI G +
Sbjct: 16 DNQSADIELKGQSKNEESKGGKKKVIIVESPAKAKTIERILGNDYQ-------------- 61
Query: 677 DKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKG 736
+++S GH+ DL + GV D +D+E
Sbjct: 62 -----VISSKGHIRDLPQKQ--FGV----------------------DLNSLKLDFE--- 89
Query: 737 VCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKR 796
+ P G +V +E +K M E+L+ +D D EGE IAW + +L NI
Sbjct: 90 IIP--GKESV---VEQIKKMTS----GKEVLLPSDQDREGEAIAWHLSTILGVKGKNI-- 138
Query: 797 IEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGR 856
I F E+T AI +A+K R+I+ ++V AQL RR+ DR +G+ +S LW + ++ SAGR
Sbjct: 139 ITFTEITERAIKEAVKNPREIDMNKVNAQLARRVLDRIVGYMISPLLWRIIKDAR-SAGR 197
Query: 857 VQTPVLGWIVQRYKE--------FTESETDFLGL----TLENG-----ISITIENAKG-- 897
VQ+ L I +R +E + + D GL T +G IT E +K
Sbjct: 198 VQSAALKIICERERERYRFVPQKYFKVWIDIAGLKAYLTKVDGKKIKPTDITEEISKDVL 257
Query: 898 -EVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE------- 949
+VK V + D+ ++E NP P+ T + QDA+ LGF +KTM++AQ+L+E
Sbjct: 258 QKVKSVRLVDIDVKEVRKNPPAPFITSTLQQDAASKLGFPVSKTMKIAQELYEGVDTKEG 317
Query: 950 -LGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYF-----------APRKWGEEGAHEA 997
TY RTDS VS+ E A+++I + G EY + K + AHE
Sbjct: 318 HTAFITYMRTDSTRVSDVAKEAAEKFILKNFGREYLNESSEVASKKGSKTKGKVQDAHEC 377
Query: 998 IRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIIS 1057
IRP T + + D KDH +LY+LI++RFIASQM A +Y++
Sbjct: 378 IRPVDVNITPEKAKELLD----------KDHHKLYELIWKRFIASQMSSA--IYKQYSYD 425
Query: 1058 TPFGDVEVEGYI-EILYDGWSRVKPLPLKQIPKLEKGQKLKV-----TEIKQWRAPKV-- 1109
G E I E ++DG+ +V + + EK ++LKV E K A
Sbjct: 426 FESGKYVFEASIRERIFDGFEKVYTIDNEPS---EKHKELKVDQEYLVEPKSAEAQTTPP 482
Query: 1110 SLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVS 1169
YT+ ++ ++ GIGRPSTYA I+QTLL RGYV+ K RK L+PT G V YL
Sbjct: 483 DRYTEASLVKTLEMEGIGRPSTYATIIQTLLDRGYVV--KKRKTLIPTILGFVVNHYLEQ 540
Query: 1170 KYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKR 1210
++ D+V + T ++EK +DE+E K D++EV++ +E +
Sbjct: 541 RFPDIVDKGFTAEMEKELDEVENGKKDWKEVVKSFLKEFNK 581
>pir||H81236 DNA topoisomerase I NMB0118 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225334|gb|AAF40577.1|
(AE002370) DNA topoisomerase I [Neisseria meningitidis
MC58]
Length = 768
Score = 237 bits (598), Expect = 6e-61
Identities = 194/613 (31%), Positives = 288/613 (46%), Gaps = 123/613 (20%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP+KA+T+ + G GD ILAS GH+ DLV G
Sbjct: 5 LLIVESPSKAKTLKKYLG-----------------GD--FEILASYGHVRDLVPKSG--- 42
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
+ D+G + Y I SRN ++V A+ A
Sbjct: 43 -AVDPDNG---FAMKYQLI-----------------------SRNG----KHVDAIVAGA 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYT--PNIK--RIEFHEVTRPAILKAIKEARD 816
E + I + TDPD EGE I+W + +L NIK R+ FHE+T+ A+L A+ R+
Sbjct: 72 KEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPRE 131
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE----- 871
I D V AQ RR D +GF LS LW+ R LSAGRVQ+P L I +R E
Sbjct: 132 IEMDLVDAQQARRALDYLVGFNLSPLLWKKI-RRGLSAGRVQSPALRLICERENEIRAFE 190
Query: 872 -----------------FTESETDFLGLTLENGISITIENAKGEV-KEVEVKDVVI---- 909
FT + G LE + E A+ +V KE+E K+ V+
Sbjct: 191 AQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQ-FDLPNEAAQADVLKELEGKEAVVTAIE 249
Query: 910 -EEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTDS 960
++R NP P+TT M QDA R LGF+ +TM+ AQ L+E +GL TY RTDS
Sbjct: 250 KKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDS 309
Query: 961 IHVSNTGIEIAKEYISEEIGEEY-------FAPRKWGEEGAHEAIRPTRPIDTGRLIQLI 1013
+++++ + + YI +IG+EY + + + AHEAIRPT T ++
Sbjct: 310 VNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPF 369
Query: 1014 RDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEV-------E 1066
L+ D F+LY +I++R +A QM PA+ I+ G V
Sbjct: 370 ----------LSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFA 419
Query: 1067 GYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEI--KQWRAPKVSLYTQGDVIALMKER 1124
G++ + + + K++P++ +G KL V ++ +Q Y + ++ ++E
Sbjct: 420 GFLSVYEESSDDEEGEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEY 479
Query: 1125 GIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLE 1184
GIGRPSTYA I+ TL R YV T +K+ +PT+ G V ++L + V T +LE
Sbjct: 480 GIGRPSTYASIISTLKDREYV--TLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLE 537
Query: 1185 KIMDEIEEAKADY 1197
+DEI + K +
Sbjct: 538 DQLDEIADGKRQW 550
>pir||A82009 DNA topoisomerase (EC 5.99.1.2) I NMA0156 [imported] - Neisseria
meningitidis (group A strain Z2491)
>gi|7378927|emb|CAB83470.1| (AL162752) DNA topoisomerase
I [Neisseria meningitidis Z2491]
Length = 768
Score = 237 bits (598), Expect = 6e-61
Identities = 194/613 (31%), Positives = 288/613 (46%), Gaps = 123/613 (20%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP+KA+T+ + G GD ILAS GH+ DLV G
Sbjct: 5 LLIVESPSKAKTLKKYLG-----------------GD--FEILASYGHVRDLVPKSG--- 42
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
+ D+G + Y I SRN ++V A+ A
Sbjct: 43 -AVDPDNG---FAMKYQLI-----------------------SRNG----KHVDAIVAGA 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYT--PNIK--RIEFHEVTRPAILKAIKEARD 816
E + I + TDPD EGE I+W + +L NIK R+ FHE+T+ A+L A+ R+
Sbjct: 72 KEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVANPRE 131
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE----- 871
I D V AQ RR D +GF LS LW+ R LSAGRVQ+P L I +R E
Sbjct: 132 IEMDLVDAQQARRALDYLVGFNLSPLLWKKI-RRGLSAGRVQSPALRLICERENEIRAFE 190
Query: 872 -----------------FTESETDFLGLTLENGISITIENAKGEV-KEVEVKDVVI---- 909
FT + G LE + E A+ +V KE+E K+ V+
Sbjct: 191 AREYWTVHLDSHKGRSKFTAKLAQYNGAKLEQ-FDLPNEAAQADVLKELEGKEAVVTAIE 249
Query: 910 -EEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTDS 960
++R NP P+TT M QDA R LGF+ +TM+ AQ L+E +GL TY RTDS
Sbjct: 250 KKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDS 309
Query: 961 IHVSNTGIEIAKEYISEEIGEEY-------FAPRKWGEEGAHEAIRPTRPIDTGRLIQLI 1013
+++++ + + YI +IG+EY + + + AHEAIRPT T ++
Sbjct: 310 VNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPF 369
Query: 1014 RDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEV-------E 1066
L+ D F+LY +I++R +A QM PA+ I+ G V
Sbjct: 370 ----------LSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFA 419
Query: 1067 GYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEI--KQWRAPKVSLYTQGDVIALMKER 1124
G++ + + + K++P++ +G KL V ++ +Q Y + ++ ++E
Sbjct: 420 GFLSVYEESSDDEEGEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEY 479
Query: 1125 GIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLE 1184
GIGRPSTYA I+ TL R YV T +K+ +PT+ G V ++L + V T +LE
Sbjct: 480 GIGRPSTYASIISTLKDREYV--TLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLE 537
Query: 1185 KIMDEIEEAKADY 1197
+DEI + K +
Sbjct: 538 DQLDEIADGKRQW 550
>pir||G64119 DNA topoisomerase (EC 5.99.1.2) - Haemophilus influenzae (strain Rd
KW20) >gi|1574197|gb|AAC23012.1| (U32816) DNA
topoisomerase I (topA) [Haemophilus influenzae Rd]
Length = 868
Score = 236 bits (596), Expect = 1e-60
Identities = 187/623 (30%), Positives = 294/623 (47%), Gaps = 99/623 (15%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
+ +L+IVESP KA+TI + G + +S GH+ DL T
Sbjct: 1 MSKSLVIVESPAKAKTINKYLGS-------------------QYVVKSSVGHIRDLPTVG 41
Query: 697 GYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALEN---- 752
G + KP D ++ + + E+ + + G HD N
Sbjct: 42 SSTG-----EKAKPISTKGMDAEEKAKIKAEK----ERNALVKRMGIDPYHDWKANYQIL 92
Query: 753 ------VKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPA 806
V ++ LA + D I + TD D EGE IAW +R V+ R+ F+E+T+ A
Sbjct: 93 PGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNDDRFSRVVFNEITKNA 152
Query: 807 ILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIV 866
I +A ++ +N DRV AQ RR DR +GF +S LW+ R LSAGRVQ+ + +V
Sbjct: 153 IKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVA-RGLSAGRVQSVAVKLLV 211
Query: 867 QRYKE---FTESETDFLGLTLEN----GISITIENAKGE-------------VKEVEVKD 906
+R +E F E + + N I + + + KG+ V + V D
Sbjct: 212 EREREIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSD 271
Query: 907 VVIEEREINPL-----PPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSI 961
V+ + E P P+ T + Q AS LGF KTM LAQ L+E G TY RTDS
Sbjct: 272 YVVTDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDST 331
Query: 962 HVSNTGIEIAKEYISEEIGEEY------FAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRD 1015
++S + +A+ YI G +Y F K + AHEAIRP+
Sbjct: 332 NLSQDALNMARSYIENHFGAQYLPEKPNFYSSKENAQEAHEAIRPS-------------- 377
Query: 1016 GIITLPRNL---TKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL 1072
I LP +L KD RLYDLI+ +F+A QM PA+ Y+ + ++ GD ++ IL
Sbjct: 378 DIRALPESLEGMEKDAVRLYDLIWCQFLACQMPPAQ--YDSSTLTVTAGDYTLKAKGRIL 435
Query: 1073 -YDGWSRVKPLPLK-----QIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKER 1124
+DGW++V P K ++P + +KL + E++ Q + +T+ ++ +++R
Sbjct: 436 RFDGWTKVLPQIGKNPEDQELPSVTVSEKLALKEVQPTQHFTKPPARFTEAALVKELEKR 495
Query: 1125 GIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLE 1184
GIGRPSTYA I+ T+ +RGYV T+ R + + G V L + +L++ + T +E
Sbjct: 496 GIGRPSTYAAIISTIQERGYV-RTENR-RFYAEKMGEIVTDRLNESFGELMNYDFTANME 553
Query: 1185 KIMDEIEEAKADYQEVLRELHEE 1207
+D+I +++ L + ++
Sbjct: 554 DTLDKIASGSVNWKTELNQFFKD 576
>sp|P43012|TOP1_HAEIN DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|687790|gb|AAC43727.1| (U20964)
DNA topoisomerase I [Haemophilus influenzae]
>gi|1587742|prf||2207242C DNA topoisomerase I
[Haemophilus influenzae]
Length = 868
Score = 236 bits (595), Expect = 1e-60
Identities = 187/623 (30%), Positives = 294/623 (47%), Gaps = 99/623 (15%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
+ +L+IVESP KA+TI + G + +S GH+ DL T
Sbjct: 1 MSKSLVIVESPAKAKTINKYLGS-------------------QYVVKSSVGHIRDLPTVG 41
Query: 697 GYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALEN---- 752
G + KP D ++ + + E+ + + G HD N
Sbjct: 42 SSTG-----EKAKPISTKGMDAEEKAKIKAEK----ERNALVKRMGIDPYHDWKANYQIL 92
Query: 753 ------VKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPA 806
V ++ LA + D I + TD D EGE IAW +R V+ R+ F+E+T+ A
Sbjct: 93 PGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNDDRFSRVVFNEITKNA 152
Query: 807 ILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIV 866
I +A ++ +N DRV AQ RR DR +GF +S LW+ R LSAGRVQ+ + +V
Sbjct: 153 IKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVA-RGLSAGRVQSVAVKLLV 211
Query: 867 QRYKE---FTESETDFLGLTLEN----GISITIENAKGE-------------VKEVEVKD 906
+R +E F E + + N I + + + KG+ V + V D
Sbjct: 212 EREREIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSD 271
Query: 907 VVIEEREINPL-----PPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSI 961
V+ + E P P+ T + Q AS LGF KTM LAQ L+E G TY RTDS
Sbjct: 272 YVVTDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDST 331
Query: 962 HVSNTGIEIAKEYISEEIGEEY------FAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRD 1015
++S + +A+ YI G +Y F K + AHEAIRP+
Sbjct: 332 NLSQDALNMARTYIENHFGAQYLPEKPNFYSSKENAQEAHEAIRPS-------------- 377
Query: 1016 GIITLPRNL---TKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL 1072
I LP +L KD RLYDLI+ +F+A QM PA+ Y+ + ++ GD ++ IL
Sbjct: 378 DIRALPESLEGMEKDAVRLYDLIWCQFLACQMPPAQ--YDSSTLTVTAGDYTLKAKGRIL 435
Query: 1073 -YDGWSRVKPLPLK-----QIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKER 1124
+DGW++V P K ++P + +KL + E++ Q + +T+ ++ +++R
Sbjct: 436 RFDGWTKVLPQIGKNPEDQELPSVTVSEKLALKEVQPTQHFTKPPARFTEAALVKELEKR 495
Query: 1125 GIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLE 1184
GIGRPSTYA I+ T+ +RGYV T+ R + + G V L + +L++ + T +E
Sbjct: 496 GIGRPSTYAAIISTIQERGYV-RTENR-RFYAEKMGEIVTDRLNESFGELMNYDFTANME 553
Query: 1185 KIMDEIEEAKADYQEVLRELHEE 1207
+D+I +++ L + ++
Sbjct: 554 DTLDKIASGSVNWKTELNQFFKD 576
>pir||D83269 DNA topoisomerase I PA3011 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9949113|gb|AAG06399.1|AE004726_5
(AE004726) DNA topoisomerase I [Pseudomonas aeruginosa]
Length = 868
Score = 233 bits (588), Expect = 9e-60
Identities = 182/620 (29%), Positives = 298/620 (47%), Gaps = 94/620 (15%)
Query: 640 ALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYH 699
+L+IVESP KA+TI + G + +S GH+ DL T+
Sbjct: 4 SLVIVESPAKAKTINKYLGS-------------------QYVVKSSIGHIRDLPTSGSSS 44
Query: 700 GVL-ILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALEN----VK 754
K P ++ R Q V + GV P+ G + ++ L +
Sbjct: 45 SKEPAAKGRKSASEAPALSPKEKAR---RQLVS--RMGVDPEHGWKAKYEILPGKEKVID 99
Query: 755 AMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA 814
+R LA + D + + TD D EGE IAW +R + KR+ F+E+T+ AI +A +
Sbjct: 100 ELRRLAKDADTVYLATDLDREGEAIAWHLREAIGGDESRYKRVVFNEITKKAIQEAFSQP 159
Query: 815 RDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYK---- 870
+++ +RV AQ RR DR +G+ +S LW+ R LSAGRVQ+ + +V+R +
Sbjct: 160 GELDINRVNAQQARRFLDRVVGYMVSPLLWQKIA-RGLSAGRVQSVAVKLVVEREREIRA 218
Query: 871 ----EFTESETDFLGLTLENGISITIENAKGE-------------VKEVEVKDVVIEERE 913
E+ E D LG + + KGE +++++ + +RE
Sbjct: 219 FVPEEYWEVHAD-LGTAKGANVRFEVTREKGEAFKPLNEAQAMAALEKLKASAYSVAKRE 277
Query: 914 -----INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGI 968
P P+ T + Q AS LGF KTM +AQ L+E G TY RTDS ++S I
Sbjct: 278 DRPTSSRPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAI 337
Query: 969 EIAKEYISEEIGEEYFAPR------KWGEEGAHEAIRPT----RPIDTGRLIQLIRDGII 1018
+ + +I +E G++Y + K G + AHEAIRP+ +P
Sbjct: 338 GMVRGFIEDEFGQKYLPGKANVYSSKEGAQEAHEAIRPSDVNLKP--------------- 382
Query: 1019 TLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL-YDGWS 1077
T + +D RLYDLI+R+F+A QM PA Y +S GD E+ IL +DG++
Sbjct: 383 TQLSGMERDAERLYDLIWRQFVACQMTPAE--YLSTSVSVTAGDFELRAKGRILKFDGYT 440
Query: 1078 RVKPLPLKQ-----IPKLEKGQKLKVTEI--KQWRAPKVSLYTQGDVIALMKERGIGRPS 1130
RV P K +P++++G+ LK+ ++ Q + Y++ ++ +++RGIGRPS
Sbjct: 441 RVLPQQSKPGEDDVLPEMKEGENLKLIKLDPSQHFTKPPARYSEASLVKELEKRGIGRPS 500
Query: 1131 TYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEI 1190
TYA I+ T+ +RGYV T ++ + G V L + +L+ T +E+ +D++
Sbjct: 501 TYAAIISTIQERGYV--TTHNRRFYAEKMGDIVTDRLNESFANLMDYGFTAGMEEHLDDV 558
Query: 1191 EEAKADYQEVLRELHEEIKR 1210
+ + D++ +L E + + K+
Sbjct: 559 AQGERDWKHLLDEFYGDFKK 578
>pdb|1ECL| Amino Terminal 67kda Domain Of Escherichia Coli Dna Topoisomerase I
(Residues 2-590 Of Mature Protein) Cloning Artifact Adds
Two Residues To The Amino-Terminus Which Were Not
Observed In The Experimental Electron Density (Gly-2,
Ser-1)
Length = 597
Score = 228 bits (575), Expect = 3e-58
Identities = 178/605 (29%), Positives = 288/605 (47%), Gaps = 87/605 (14%)
Query: 640 ALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYH 699
AL+IVESP KA+TI + G + +S GH+ DL +
Sbjct: 4 ALVIVESPAKAKTINKYLGSD-------------------YVVKSSVGHIRDLTSGSAAK 44
Query: 700 GVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALEN----VKA 755
K T K+ + + + GV P ++ L V
Sbjct: 45 ---------KSADSTSTKTAKKPKKPDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSE 95
Query: 756 MRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEAR 815
+++LA + D I + TD D EGE IAW +R V+ R+ F+E+T+ AI +A +
Sbjct: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG 155
Query: 816 DINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEF--- 872
++N DRV AQ RR DR +G+ +S LW+ R LSAGRVQ+ + +V+R +E
Sbjct: 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKAF 214
Query: 873 --------------TESETDFLGLTLENG---ISITIENAKGEVKEVEVKDVVIEEREIN 915
E L +T +N + E + V +E + ERE
Sbjct: 215 VPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDK 274
Query: 916 PL-----PPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEI 970
P P+ T + Q AS LGF KTM +AQ L+E G TY RTDS ++S + +
Sbjct: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM 334
Query: 971 AKEYISEEIGEEYF--APRKWGEEG----AHEAIRPTRPIDTGRLIQLIRDGIITLPRNL 1024
+ YIS+ G++Y +P ++ +G AHEAIRP+ D + + ++D +
Sbjct: 335 VRGYISDNFGKKYLPESPNQYASKGNSQEAHEAIRPS---DVNVMAESLKD--------M 383
Query: 1025 TKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL-YDGWSRVKPLP 1083
D +LY LI+R+F+A QM PA+ Y+ ++ GD ++ IL +DGW++V P
Sbjct: 384 EADAQKLYQLIWRQFVACQMTPAK--YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL 441
Query: 1084 LKQ-----IPKLEKGQKLKVTEI--KQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIV 1136
K +P + KG L + E+ Q + +++ ++ +++RGIGRPSTYA I+
Sbjct: 442 RKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASII 501
Query: 1137 QTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKAD 1196
T+ RGYV ++ + G V L +++L++ + T Q+E +D++ +A+
Sbjct: 502 STIQDRGYV--RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559
Query: 1197 YQEVL 1201
++ VL
Sbjct: 560 WKAVL 564
>sp|P06612|TOP1_ECOLI DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7428456|pir||ISECTP DNA
topoisomerase (EC 5.99.1.2) - Escherichia coli
>gi|415338|emb|CAA28164.1| (X04475) put. DNA
topoisomerase I (AA 1-864) [Escherichia coli]
>gi|1742069|dbj|BAA14811.1| (D90764) DNA topoisomerase I
(EC 5.99.1.2) (w-protein) (Relaxing enzyme) (Untwisting
enzyme) (Swivelase). [Escherichia coli]
>gi|1742085|dbj|BAA14826.1| (D90765) DNA topoisomerase I
(EC 5.99.1.2) (w-protein) (Relaxing enzyme) (Untwisting
enzyme) (Swivelase). [Escherichia coli]
>gi|1787529|gb|AAC74356.1| (AE000225) DNA topoisomerase
type I, omega protein [Escherichia coli K12]
Length = 865
Score = 226 bits (570), Expect = 1e-57
Identities = 181/603 (30%), Positives = 286/603 (47%), Gaps = 83/603 (13%)
Query: 640 ALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYH 699
AL+IVESP KA+TI + G + +S GH+ DL T+
Sbjct: 4 ALVIVESPAKAKTINKYLGSD-------------------YVVKSSVGHIRDLPTSGSAA 44
Query: 700 GVLILKDDGKPYYVPVYDTIKRCRDCGHQFVD----WEQK-GVCPKCGSRNVHDALENVK 754
K P D +R VD WE V P G V V
Sbjct: 45 KKSADSTSTKTAKKPKKD--ERGALVNRMGVDPWHNWEAHYEVLP--GKEKV------VS 94
Query: 755 AMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA 814
+++LA + D I + TD D EGE IAW +R V+ R+ F+E+T+ AI +A +
Sbjct: 95 ELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP 154
Query: 815 RDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEF-- 872
++N DRV AQ RR DR +G+ +S LW+ R LSAGRVQ+ + +V+R +E
Sbjct: 155 GELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKA 213
Query: 873 ---------------TESETDFLGLTLENG---ISITIENAKGEVKEVEVKDVVIEEREI 914
E L +T +N + E + V +E + ERE
Sbjct: 214 FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED 273
Query: 915 NPL-----PPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIE 969
P P+ T + Q AS LGF KTM +AQ L+E G TY RTDS ++S +
Sbjct: 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN 333
Query: 970 IAKEYISEEIGEEYF--APRKW-GEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTK 1026
+ + YIS+ G++Y +P ++ +E + EA RP D + + ++D +
Sbjct: 334 MVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD--------MEA 385
Query: 1027 DHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL-YDGWSRVKPLPLK 1085
D +LY LI+R+F+A QM PA+ Y+ ++ GD ++ IL +DGW++V P K
Sbjct: 386 DAQKLYQLIWRQFVACQMTPAK--YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK 443
Query: 1086 Q-----IPKLEKGQKLKVTEI--KQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQT 1138
+P + KG L + E+ Q + +++ ++ +++RGIGRPSTYA I+ T
Sbjct: 444 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503
Query: 1139 LLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQ 1198
+ RGYV ++ + G V L +++L++ + T Q+E +D++ +A+++
Sbjct: 504 IQDRGYV--RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 561
Query: 1199 EVL 1201
VL
Sbjct: 562 AVL 564
>pdb|1CY7|A Chain A, Complex Of E.Coli Dna Topoisomerase I With 5'-Thymidine
Monophosphate >gi|7245303|pdb|1CY8|A Chain A, Complex Of
E.Coli Dna Topoisomerase I With 5'-Thymidine
Monophosphate And 3'-Thymidine Monophosphate
>gi|7245301|pdb|1CY6|A Chain A, Complex Of E.Coli Dna
Topoisomerase I With 3' Thymidine Monophosphate
>gi|7245486|pdb|1CY4|A Chain A, Complex Of E.Coli Dna
Topoisomerase I With 5'ptptptp3' >gi|7245299|pdb|1CY1|A
Chain A, Complex Of E.Coli Dna Topoisomerase I With
5'ptptpt >gi|7245300|pdb|1CY2|A Chain A, Complex Of
E.Coli Dna Topoisomerase I With Tptptp3'
>gi|7245485|pdb|1CY0|A Chain A, Complex Of E.Coli Dna
Topoisomerase I With 3'-5'-Adenosine Diphosphate
Length = 599
Score = 226 bits (570), Expect = 1e-57
Identities = 181/603 (30%), Positives = 286/603 (47%), Gaps = 83/603 (13%)
Query: 640 ALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYH 699
AL+IVESP KA+TI + G + +S GH+ DL T+
Sbjct: 6 ALVIVESPAKAKTINKYLGSD-------------------YVVKSSVGHIRDLPTSGSAA 46
Query: 700 GVLILKDDGKPYYVPVYDTIKRCRDCGHQFVD----WEQK-GVCPKCGSRNVHDALENVK 754
K P D +R VD WE V P G V V
Sbjct: 47 KKSADSTSTKTAKKPKKD--ERGALVNRMGVDPWHNWEAHYEVLP--GKEKV------VS 96
Query: 755 AMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA 814
+++LA + D I + TD D EGE IAW +R V+ R+ F+E+T+ AI +A +
Sbjct: 97 ELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP 156
Query: 815 RDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEF-- 872
++N DRV AQ RR DR +G+ +S LW+ R LSAGRVQ+ + +V+R +E
Sbjct: 157 GELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKA 215
Query: 873 ---------------TESETDFLGLTLENG---ISITIENAKGEVKEVEVKDVVIEEREI 914
E L +T +N + E + V +E + ERE
Sbjct: 216 FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED 275
Query: 915 NPL-----PPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIE 969
P P+ T + Q AS LGF KTM +AQ L+E G TY RTDS ++S +
Sbjct: 276 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN 335
Query: 970 IAKEYISEEIGEEYF--APRKW-GEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTK 1026
+ + YIS+ G++Y +P ++ +E + EA RP D + + ++D +
Sbjct: 336 MVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD--------MEA 387
Query: 1027 DHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL-YDGWSRVKPLPLK 1085
D +LY LI+R+F+A QM PA+ Y+ ++ GD ++ IL +DGW++V P K
Sbjct: 388 DAQKLYQLIWRQFVACQMTPAK--YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK 445
Query: 1086 Q-----IPKLEKGQKLKVTEI--KQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQT 1138
+P + KG L + E+ Q + +++ ++ +++RGIGRPSTYA I+ T
Sbjct: 446 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 505
Query: 1139 LLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQ 1198
+ RGYV ++ + G V L +++L++ + T Q+E +D++ +A+++
Sbjct: 506 IQDRGYV--RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 563
Query: 1199 EVL 1201
VL
Sbjct: 564 AVL 566
>sp|Q9KRB2|TOP1_VIBCH DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|11270791|pir||B82163 DNA
topoisomerase I VC1730 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9656251|gb|AAF94880.1|
(AE004251) DNA topoisomerase I [Vibrio cholerae]
Length = 876
Score = 224 bits (564), Expect = 6e-57
Identities = 184/621 (29%), Positives = 292/621 (46%), Gaps = 94/621 (15%)
Query: 640 ALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYH 699
+L+IVESP KA+TI + G K + +S GH+ DL T
Sbjct: 4 SLVIVESPAKAKTINKYLG-------------------KDFIVKSSVGHVRDLPTAG--- 41
Query: 700 GVLILKDDGKPYYVPVYDTIKRCR--DCGHQFVDWEQKGVCPKCGSRNVHDALEN----- 752
P + K+ D Q + E+ + K G H N
Sbjct: 42 ------QTATPTGKAAAASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILP 95
Query: 753 -----VKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAI 807
V +++LA + D + + TD D EGE IAW +R ++ KR+ F+E+T+ AI
Sbjct: 96 GKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAI 155
Query: 808 LKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQ 867
+A K+ ++N D V AQ RR DR +GF +S LW+ R LSAGRVQ+ + +V+
Sbjct: 156 QQAFKQPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVA-RGLSAGRVQSVAVKLLVE 214
Query: 868 RYKE----------------FTESETDF-LGLTLENGISITIEN---AKGEVKEVEVKDV 907
R +E T + DF L + ++G++ N A V +
Sbjct: 215 REREIKAFVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQY 274
Query: 908 VIEERE-----INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIH 962
+ +RE P P+ T + Q AS LG+ KTM LAQ L+E G TY RTDS +
Sbjct: 275 EVCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTN 334
Query: 963 VSNTGIEIAKEYISEEIGEEYFAPR------KWGEEGAHEAIRPTRPIDTGRLIQLIRDG 1016
+S +E + YI++ GE Y + K + AHEAIRP+ + + D
Sbjct: 335 LSAEAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSD-------VTVTADD 387
Query: 1017 IITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL-YDG 1075
+ + D +LY LI+ +F+A QM PA+ Y+ +S + ++ IL +DG
Sbjct: 388 L----EGMEADAHKLYALIWNQFVACQMTPAQ--YDSTTVSVKAAEYTLKAKGRILKFDG 441
Query: 1076 WSRV-KPLPLKQ---IPKLEKGQKLKVTEI--KQWRAPKVSLYTQGDVIALMKERGIGRP 1129
W+RV +PL + +P ++ G LK+ + KQ + YT+ ++ +++RGIGRP
Sbjct: 442 WTRVQRPLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRP 501
Query: 1130 STYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDE 1189
STYA I+ T+ RGYV +++ + G V L + DL++ + T ++E+ +D+
Sbjct: 502 STYASIISTIQDRGYV--KVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQ 559
Query: 1190 IEEAKADYQEVLRELHEEIKR 1210
I E + ++ VL E + R
Sbjct: 560 IAEGEVNWTAVLDEFFADFSR 580
>sp|P55991|TOP1_HELPY DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7449001|pir||D64534 DNA
topoisomerase I - Helicobacter pylori (strain 26695)
>gi|2313198|gb|AAD07184.1| (AE000533) DNA topoisomerase I
(topA) [Helicobacter pylori 26695]
Length = 736
Score = 221 bits (558), Expect = 3e-56
Identities = 180/613 (29%), Positives = 291/613 (47%), Gaps = 119/613 (19%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI +F DK ++AS GH+ DL ++ G
Sbjct: 4 LIIVESPAKAKTIKNFL-------------------DKNYEVIASKGHVRDL--SKFALG 42
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
+ I + P YV VD + K E VK + EL+
Sbjct: 43 IKIDETGFTPNYV----------------VDKDHK---------------ELVKQIIELS 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINED 820
+ I TD D EGE I + + ++ + RI FHE+T+ AIL A+K R I+
Sbjct: 72 KKASITYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRKIDMS 131
Query: 821 RVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE---FTESET 877
+V AQ RR DR +GF+LS + + LSAGRVQ+ L ++ + +E F
Sbjct: 132 KVNAQQARRFLDRIVGFKLSSLIASKI-TKGLSAGRVQSAALKLVIDKEREIKAFKPLTY 190
Query: 878 DFLGLTLENGISITIENAKG----------EVKEVEVKD-----------VVIEEREINP 916
L E+ + + + KG E K E+K+ +V + ++
Sbjct: 191 FTLDAYFESHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYAISSIVKKSKKSPT 250
Query: 917 LPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTDSIHVSNTGI 968
PP+ T + Q AS LGFS TKTM +AQ L+E +G+ TY RTDS++++ +
Sbjct: 251 PPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEAL 310
Query: 969 EIAKEYISEEIGEEYFAP-------RKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLP 1021
E A+ I ++ G++Y P + + AHEAIRPT I L
Sbjct: 311 EEARNKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTS---------------IILE 355
Query: 1022 RNLTKDH-----FRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGW 1076
N KD+ RLY LI++RF+ASQM+ A + +++ G+ + G ++L+DG+
Sbjct: 356 PNALKDYLKPEELRLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGR-KLLFDGY 414
Query: 1077 SRV--KPLPLKQIPKLEKGQKLKVTEIKQ--WRAPKVSLYTQGDVIALMKERGIGRPSTY 1132
++ K +P L++ +K+ +++ + Y++ +I +++ GIGRPSTY
Sbjct: 415 YKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTY 474
Query: 1133 AKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEE 1192
A + L R Y+ K K++ E KV + L ++++V + + LE+ +D I +
Sbjct: 475 APTISLLQNRDYIKVEK--KQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQ 532
Query: 1193 AKADYQEVLRELH 1205
KADYQ+VL++ +
Sbjct: 533 NKADYQQVLKDFY 545
>emb|CAA71737.1| (Y10747) topoisomerase I [Helicobacter pylori]
Length = 736
Score = 220 bits (554), Expect = 9e-56
Identities = 180/613 (29%), Positives = 288/613 (46%), Gaps = 119/613 (19%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI +F DK ++AS GH+ DL ++ G
Sbjct: 4 LIIVESPAKAKTIKNFL-------------------DKNYEVIASKGHVRDL--SKFALG 42
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
+ I + P YV VD + K E VK + EL+
Sbjct: 43 IKIDETGFTPNYV----------------VDKDHK---------------ELVKQIIELS 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINED 820
+ I TD D EGE I + + ++ + RI FHE+T+ AIL A+K R I+
Sbjct: 72 KKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRQIDMS 131
Query: 821 RVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE---FTESET 877
+V AQ RR DR +GF+LS + + LSAGRVQ+ L ++ R +E F
Sbjct: 132 KVNAQQARRFLDRIVGFKLSSLISSKI-TKGLSAGRVQSAALKLVIDREREIKAFKPLTY 190
Query: 878 DFLGLTLENGISITIENAKG----------EVKEVEVKD-----------VVIEEREINP 916
L E + + + KG E K E+K+ +V + ++
Sbjct: 191 FTLDAYFEPNLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYTISSIVKKSKKSPT 250
Query: 917 LPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTDSIHVSNTGI 968
PP+ T + Q AS LGFS TKTM +AQ L+E +G+ TY RTDS++++
Sbjct: 251 PPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEAS 310
Query: 969 EIAKEYISEEIGEEYFAP-------RKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLP 1021
E A+ I ++ G++Y P + + AHEAIRPT I L
Sbjct: 311 EEARAKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTS---------------IILE 355
Query: 1022 RNLTKDH-----FRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGW 1076
N KD+ +LY LI++RF+ASQM+ A + +++ G+ + G ++L+DG+
Sbjct: 356 PNALKDYLKPEELKLYALIYKRFLASQMQDALFESQSVVVACEKGEFKASGR-KLLFDGY 414
Query: 1077 SRV--KPLPLKQIPKLEKGQKLKVTEIKQ--WRAPKVSLYTQGDVIALMKERGIGRPSTY 1132
++ K +P L++ +K+ ++ + Y++ +I +++ GIGRPSTY
Sbjct: 415 YKILGNDDKDKLLPNLKENDPIKLERLESNAHVTESPARYSEASLIKVLESLGIGRPSTY 474
Query: 1133 AKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEE 1192
A + L R Y+ K K++ E KV + L ++++V + + LE+ +D I +
Sbjct: 475 APTISLLQNRDYIKVEK--KQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQ 532
Query: 1193 AKADYQEVLRELH 1205
KADYQ+VL++ +
Sbjct: 533 NKADYQQVLKDFY 545
>sp|Q9ZMV7|TOP1_HELPJ DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7449000|pir||B71972 DNA
topoisomerase I - Helicobacter pylori (strain J99)
>gi|4154624|gb|AAD05695.1| (AE001450) DNA TOPOISOMERASE I
[Helicobacter pylori J99]
Length = 736
Score = 217 bits (548), Expect = 5e-55
Identities = 181/613 (29%), Positives = 291/613 (46%), Gaps = 119/613 (19%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI +F DK ++AS GH+ DL ++ G
Sbjct: 4 LIIVESPAKAKTIKNFL-------------------DKNYEVVASKGHVRDL--SKFALG 42
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
+ I + P YV VD + K E VK + EL+
Sbjct: 43 IKIDETGFTPNYV----------------VDKDHK---------------ELVKQIIELS 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINED 820
+ I TD D EGE I + + ++ + RI FHE+T+ AIL +K R I+
Sbjct: 72 KKASITYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNVLKTPRKIDMF 131
Query: 821 RVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE---FTESET 877
+V AQ RR+ DR +GF+LS + + LSAGRVQ+ L ++ R KE F
Sbjct: 132 KVNAQQARRLLDRIVGFKLSSLIASKI-TKGLSAGRVQSAALKLVIDREKEIRPFKPLTY 190
Query: 878 DFLGLTLENGISITIENAKG----------EVKEVEVKD----------VVIEEREINPL 917
L E + + + KG E K E+K+ +I++ + +P
Sbjct: 191 FTLDALFEPHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYIISSIIKKSKKSPT 250
Query: 918 -PPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTDSIHVSNTGI 968
PP+ T + Q AS LGFS TKTM +AQ L+E +G+ TY RTDS++++ +
Sbjct: 251 PPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEAL 310
Query: 969 EIAKEYISEEIGEEYFAP-------RKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLP 1021
E A+ I ++ G++Y P + + AHEAIRPT I L
Sbjct: 311 EEARAKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTS---------------IILE 355
Query: 1022 RNLTKDH-----FRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGW 1076
N KD+ +LY LI++RF+ASQM+ A + +++ G+ + G ++L+DG
Sbjct: 356 PNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGR-KLLFDGH 414
Query: 1077 SRV--KPLPLKQIPKLEKGQKLKVTEIKQ--WRAPKVSLYTQGDVIALMKERGIGRPSTY 1132
++ K +P L++ +K+ +++ + Y++ +I +++ GIGRPSTY
Sbjct: 415 YKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTY 474
Query: 1133 AKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEE 1192
A + L R Y+ K K++ E KV + L ++++V + + LE+ +D I +
Sbjct: 475 APTISLLQNRDYIKVEK--KQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQ 532
Query: 1193 AKADYQEVLRELH 1205
KADYQ+VL++ +
Sbjct: 533 NKADYQQVLKDFY 545
>sp|O83409|TOP1_TREPA DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7449004|pir||D71332 probable DNA
topoisomerase I (topA) - syphilis spirochete
>gi|3322672|gb|AAC65378.1| (AE001217) DNA topoisomerase I
(topA) [Treponema pallidum]
Length = 731
Score = 216 bits (544), Expect = 1e-54
Identities = 186/631 (29%), Positives = 287/631 (45%), Gaps = 121/631 (19%)
Query: 625 IEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILA 684
+ G ++ K + L+IVESP KA+TI + G + A
Sbjct: 3 VRGLQPKRQKTFARKHLVIVESPAKAQTIEKYLGT-------------------QYVVRA 43
Query: 685 SGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSR 744
S GH+ DL + L D + + P Y T++ C
Sbjct: 44 SMGHVIDLPKSR-------LAIDIEHDFQPEYITVRGRAQC------------------- 77
Query: 745 NVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPY--TPNIKRIEFHEV 802
+K +R L+ + ++ + +D D EGE IA+ + + Y TP IKRI F+E+
Sbjct: 78 --------LKELRTLSKQSLQVFLASDRDREGEAIAYHLAQSIQAYCDTP-IKRIVFNEI 128
Query: 803 TRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVL 862
T AI AI I+ +V AQ RR+ DR +G+ L LW +N LSAGRVQ+ L
Sbjct: 129 TPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCPLLWHKVKN-GLSAGRVQSVAL 187
Query: 863 GWIVQR---YKEFTESETDFLGLTLE------NGISITIENAKGEVK------------- 900
I +R K F E + T E + + I I+ K K
Sbjct: 188 RLICEREVEVKRFVPEEYWTVEGTFEKDKKSFSALLILIQGKKAVFKSKQEATSAIGLFS 247
Query: 901 --EVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------L 950
E V + E+ + P P+TT + Q A+ LGF++ KTMQ+AQ L+E +
Sbjct: 248 QSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTSRKTMQVAQQLYEGVSLGTHRV 307
Query: 951 GLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEY-FAPRKWGEEG----AHEAIRPTRPID 1005
GL TY RTDS+ VS ++ + +I+ + P ++ +G AHEAIRPT
Sbjct: 308 GLITYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPNRYAAKGKSQDAHEAIRPTYVAH 367
Query: 1006 TGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARV---LYEKAIISTPFGD 1062
T I+ +LT+D RLY LI+ RF+ASQM ARV +E F
Sbjct: 368 TPERIK----------AHLTRDQIRLYTLIWERFVASQMTDARVRSLTFEITAGPAVFSA 417
Query: 1063 VEVEGYIEILYDGWSRV------KPLPLKQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQ 1114
E +++ G+ RV K L +P ++G+ + + ++ Q YT
Sbjct: 418 TET----QVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTD 473
Query: 1115 GDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDL 1174
++ +++E+GIGRPSTYA + LL R YV T+ +K+L+PT G + L + + D+
Sbjct: 474 ASIVKMLEEKGIGRPSTYAPTISVLLDRYYV--TRIQKQLMPTPLGKVISDLLTTYFHDV 531
Query: 1175 VSEERTRQLEKIMDEIEEAKADYQEVLRELH 1205
V T ++E +DE+EE K + V+ + +
Sbjct: 532 VDVSFTARMESKLDEVEEDKIKWNCVIADFY 562
>sp|P73810|TOP1_SYNY3 DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7437430|pir||S74903 DNA
topoisomerase I - Synechocystis sp. (strain PCC 6803)
>gi|1652946|dbj|BAA17864.1| (D90909) DNA topoisomerase I
[Synechocystis sp.]
Length = 898
Score = 215 bits (541), Expect = 3e-54
Identities = 187/632 (29%), Positives = 274/632 (42%), Gaps = 128/632 (20%)
Query: 639 SALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGY 698
S L+IVESP KARTI ++ Q + + AS GH+ DL +
Sbjct: 2 SKLVIVESPTKARTIRNYLPQDYR-------------------VEASMGHVRDLPASAEE 42
Query: 699 HGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVD-WEQKGVCPKCGSRNVHDALENVKAMR 757
VP K + G D + V PK + V K ++
Sbjct: 43 --------------VPAAYKDKSWANLGVNVEDHFSPLYVIPKSKKKVV-------KELQ 81
Query: 758 ELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDI 817
DE+++ TD D EGE I+W + +L P P IKR+ FHE+T+ AI A++ RDI
Sbjct: 82 TALKNADEVILATDEDREGESISWHLLQLLQPKVP-IKRMVFHEITQEAIRSALENCRDI 140
Query: 818 NEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYK------- 870
+E+ V AQ RRI DR +G+ LS LW+ LSAGRVQ+ + IVQR +
Sbjct: 141 DENLVHAQETRRILDRLVGYTLSPLLWKKIA-WGLSAGRVQSVAVRLIVQRERARRAFKT 199
Query: 871 --------EFTESETDFL-------GLTLENGISITIENA-----KGEVKEVEVKDVVIE 910
E +++ F G L NG K V E + + ++
Sbjct: 200 AGYWDLKAELEQNKNPFQAKLMTLGGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALK 259
Query: 911 EREIN----------------PLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCT 954
ER P PP+TT + Q+A+R LG SA TM++AQ L+E G T
Sbjct: 260 ERLTGKPWAVVNTEEKPGVRKPSPPFTTSTLQQEANRKLGISARDTMRVAQKLYEEGYIT 319
Query: 955 YHRTDSIHVSNTGIEIAKEYISEEIGEEYFAP-------RKWGEEGAHEAIRPTR----- 1002
Y RTDS+H+S+ + A+ + + G+EY +P + G + AHEAIRP
Sbjct: 320 YMRTDSVHLSDQAVTAARNCVQQMYGKEYLSPQPKQYTTKSKGAQEAHEAIRPAGTEFRI 379
Query: 1003 PIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGD 1062
P TG L LY+LI++R +A QM AR+ ++ +
Sbjct: 380 PNQTG----------------LKDRELALYELIWKRTVACQMADARITQLSVLLKVEDAE 423
Query: 1063 -------VEVEGYIEILYDGWSRVKPLPLKQ---IPKLEKGQKLKVTEIKQ--WRAPKVS 1110
++ GY +G Q +P L+ G + EI +
Sbjct: 424 FRAAGKRIDFPGYFRAYVEGSDDPDAALENQEVILPPLKVGDRPNCREIDTVGHETQPPA 483
Query: 1111 LYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSK 1170
YT+ ++ ++ G+GRPSTYA I+ T++ RGYV K L PT V L S
Sbjct: 484 RYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYV--QMRSKALTPTFTAFAVVSLLESH 541
Query: 1171 YKDLVSEERTRQLEKIMDEIEEAKADYQEVLR 1202
+ DLV T ++E+ +DEI K + L+
Sbjct: 542 FPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQ 573
>pir||B82746 DNA topoisomerase I XF0920 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9105841|gb|AAF83730.1|AE003931_7 (AE003931) DNA
topoisomerase I [Xylella fastidiosa]
Length = 815
Score = 213 bits (536), Expect = 1e-53
Identities = 186/639 (29%), Positives = 289/639 (45%), Gaps = 137/639 (21%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI + G K T+LAS GH+ DLV EG
Sbjct: 5 LLIVESPAKAKTINKYLG-------------------KDFTVLASYGHVRDLVPKEG--- 42
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
D + + YD I + ++V+A+ + A
Sbjct: 43 ----AVDPENGFAMRYDLIDKNE---------------------------KHVEAITKAA 71
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPY----TPNIKRIEFHEVTRPAILKAIKEARD 816
D I + TDPD EGE I+W I +L ++RI F E+T AI +AI++ R
Sbjct: 72 KTADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRM 131
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESE 876
I D V AQ RR D +GF LS LW + R LSAGRVQ+P L IV+R +E
Sbjct: 132 IASDLVDAQQARRALDYLVGFNLSPVLWRKVQ-RGLSAGRVQSPALRMIVEREEEIEAFI 190
Query: 877 T---------------------------DFLGLTLENGISITIENAKGEVKEV-----EV 904
T F T+ + S T A+ +++V +
Sbjct: 191 TREYWSIHAECAHPAQHFSAKLIKLDGQKFEQFTITD--SDTAAAAQRRIQQVAQGRLHI 248
Query: 905 KDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE---------LGLCTY 955
DV +ER+ P PP+ T + Q+ASR LGF+ KTMQ+AQ L+E +GL TY
Sbjct: 249 TDVTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITY 308
Query: 956 HRTDSIHVSNTGIEIAKEYISEEIG-------EEYFAPRKWGEEGAHEAIRPTRPIDTGR 1008
RTDS+++S + ++ I+ + G + + + AHEA+RPT + T
Sbjct: 309 MRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPT 368
Query: 1009 LIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGD------ 1062
+ L+ + RLY+L+++R +ASQM PA + + G+
Sbjct: 369 QV----------APYLSNEEHRLYELVWKRAVASQMIPA--ILNTTSVDLAAGNEHVFRA 416
Query: 1063 ----VEVEGYIEILYDGWSRVKPL---PLKQIPKLEKGQKLKVTEI--KQWRAPKVSLYT 1113
V V+G++ + +G +++P ++ G+ + + I +Q YT
Sbjct: 417 TGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPPRYT 476
Query: 1114 QGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKD 1173
+ ++ ++E GIGRPSTYA I+QTLL R YV + +GR PT+ G V ++L S +
Sbjct: 477 EAALVKALEEYGIGRPSTYASIIQTLLFRKYV-DMEGR-SFRPTDIGRAVSKFLASHFTR 534
Query: 1174 LVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYI 1212
V + T LE +D I + ++ ++++ K +
Sbjct: 535 YVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPFKELV 573
>sp|Q9X909|TOP1_STRCO DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7480634|pir||T36664 probable DNA
topoisomerase I - Streptomyces coelicolor
>gi|4539561|emb|CAB38480.1| (AL035636) probable DNA
topoisomerase I [Streptomyces coelicolor A3(2)]
Length = 952
Score = 212 bits (533), Expect = 3e-53
Identities = 200/649 (30%), Positives = 292/649 (44%), Gaps = 151/649 (23%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVT-----T 695
L+IVESP KA+TI + G Y V AS GH+ DL +
Sbjct: 14 LVIVESPAKAKTIKGYLGP----------GYVVE---------ASVGHIRDLPSGAAEVP 54
Query: 696 EGYHG-VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVK 754
E Y G V L D + + P+Y V+ ++K VK
Sbjct: 55 EKYTGEVRRLGVDVEHDFQPIY------------VVNADKKS---------------QVK 87
Query: 755 AMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA 814
+++L E DE+ + TD D EGE IAW ++ VL P P +KR+ FHE+T+ AI A+
Sbjct: 88 KLKDLLKESDELFLATDEDREGEAIAWHLQEVLKPKIP-VKRMVFHEITKDAIRAAVANP 146
Query: 815 RDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE--- 871
R++N+ V AQ RRI DR G+E+S LW+ R LSAGRVQ+ +V+R +E
Sbjct: 147 RELNQKLVDAQETRRILDRLYGYEVSPVLWKKVMPR-LSAGRVQSVATRLVVERERERIA 205
Query: 872 FTESE---------------------------------------TDFLG-LTLENGISIT 891
F +E D LG L N + +
Sbjct: 206 FRSAEYWDLTGTFATGRAGDASDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSANTLHLD 265
Query: 892 IENAKGEVKEVE-----VKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQD 946
NA+ +E V+ V + +P P+ T + Q+ASR LGF A TMQ+AQ
Sbjct: 266 EANARALAAALENTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKSTMQVAQK 325
Query: 947 LFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEG-------AHEAIR 999
L+E G TY RTDS +S+T + A+ +++ G +Y P+ G AHEAIR
Sbjct: 326 LYENGYITYMRTDSTTLSDTAVSAARAQVTQLYGADYLPPQPRTYAGKVKNAQEAHEAIR 385
Query: 1000 PT-----RPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPA---RVLY 1051
P+ P +TG LT D F+LY+LI++R +ASQMK A V
Sbjct: 386 PSGDRFRTPAETG----------------LTGDQFKLYELIWKRTVASQMKDATGNSVTV 429
Query: 1052 EKAIISTPFGDVE-------------VEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKV 1098
+ ++ DVE ++ Y+E D + + +++P++ +G L
Sbjct: 430 KIGGAASDGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDRE-RRLPQVAEGDALTA 488
Query: 1099 TEIK-QWRAPK-VSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVP 1156
EI A K + YT+ ++ ++ER IGRPSTYA I+ T+L RGYV K LVP
Sbjct: 489 EEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVF--KKGTALVP 546
Query: 1157 TEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELH 1205
+ V L + LV + T ++E +D I +A LR +
Sbjct: 547 SFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRRFY 595
>gb|AAD21553.1| (AF088896) topoisomerase I [Zymomonas mobilis]
Length = 1217
Score = 210 bits (528), Expect = 1e-52
Identities = 184/633 (29%), Positives = 284/633 (44%), Gaps = 132/633 (20%)
Query: 633 VKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDL 692
V+ ++K L++VESP KA+TI + G Y+V LAS GH+ DL
Sbjct: 2 VRSIMK--LVVVESPAKAKTIEKYLGS----------GYQV---------LASYGHIRDL 40
Query: 693 VTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALEN 752
+ +G D G V W+ N D
Sbjct: 41 PSKDGSVNP----------------------DNGFSMV-WQ-----------NYPDKAHR 66
Query: 753 VKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSP---YTPNIKRIEFHEVTRPAILK 809
+KA+ + E D +++ TDPD EGE I+W I +L +++R+ F+ +T+ A+
Sbjct: 67 LKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTD 126
Query: 810 AIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRY 869
A+ R ++ D + A L RR D +GF LS LW SAGRVQ+ L +V R
Sbjct: 127 AMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAK-SAGRVQSARLRLVVDRE 185
Query: 870 KEF------------TESETDFLGLT-------------LENGISITIENAKGEVKEVEV 904
+E + E D +G T L E A+ +V+
Sbjct: 186 QEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHF 245
Query: 905 KDVVIEEREI--NPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIH 962
+E + + NP PP+TT + Q+A+R LGF+A+ TM+LAQ L+E GL TY RTD +
Sbjct: 246 TVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQ 305
Query: 963 VSNTGIEIAKEYISEEIGEEYF--APRKW-----GEEGAHEAIRPTRPIDTGRLIQLIRD 1015
+ + I A++ I++ Y PR++ + AHEAIRPT RD
Sbjct: 306 MDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPT---------DFSRD 356
Query: 1016 GIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGD----VEVEGYIEI 1071
+ + DH RLY+LI++R +ASQM A++ E+ + G + V G + +
Sbjct: 357 ------KAASGDHARLYELIWKRALASQMASAKL--ERTTVDLTDGTGQNVLRVTGQV-V 407
Query: 1072 LYDGW-------------SRVKPLPLKQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGD 1116
L+ G+ R ++P L G E + Q Y++
Sbjct: 408 LFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEFRADQHFTQPPPRYSEAS 467
Query: 1117 VIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVS 1176
++ M++ GIGRPSTYA +Q L R YV T R + +P+E G + +L ++ VS
Sbjct: 468 LVKKMEDLGIGRPSTYASFIQVLKDRAYV--TLERNRFIPSEAGRLLTAFLERFFERYVS 525
Query: 1177 EERTRQLEKIMDEIEEAKADYQEVLRELHEEIK 1209
+ T LE +DEI +AD+Q+VL + K
Sbjct: 526 YDFTAGLEDSLDEISGGRADWQKVLDAFWHDFK 558
>sp|Q9ZDK2|TOP1_RICPR DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7437433|pir||H71688 DNA
topoisomerase I (topA) RP326 - Rickettsia prowazekii
>gi|3860886|emb|CAA14786.1| (AJ235271) DNA TOPOISOMERASE
I (topA) [Rickettsia prowazekii]
Length = 776
Score = 205 bits (516), Expect = 3e-51
Identities = 187/637 (29%), Positives = 289/637 (45%), Gaps = 133/637 (20%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI + G K ++AS GH+ DL + +G
Sbjct: 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKGS-- 41
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
+L D ++ YD + K G + V A+ + A
Sbjct: 42 --VLPDKN---FLMEYD-------------------ISDKAG--------KYVDAIVKEA 69
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPN-----IKRIEFHEVTRPAILKAIKEAR 815
+ + + + TDPD EGE I+W + V+ KR+ F+E+T+ AI+ A+ R
Sbjct: 70 RKAEVVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIMNAVANPR 129
Query: 816 DINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE---F 872
++ + V AQ RR D +GF LS LW SAGRVQ+ L I R E F
Sbjct: 130 KLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCK-SAGRVQSVALRLICDREDEIERF 188
Query: 873 TESETDFLGLTLENGIS--------------------ITIENAKGEVKEVEVKDVVIE-- 910
E + L ++N + I + AK ++++++ +E
Sbjct: 189 KSEEYWDISLKMQNSNNDLFTAKLTHVNDQKLKKFSIINEKEAKDLTQKLKLQKFYVEKI 248
Query: 911 ---EREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRTD 959
+++ P PP+ T ++ Q+A+R LGFSA KTMQ+AQ L+E +GL TY RTD
Sbjct: 249 EKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTD 308
Query: 960 SIHVSNTGIEIAKEYISEEIGEEY--FAPRKW-----GEEGAHEAIRPTRPIDTGRLIQL 1012
+ +SN I ++ I + G +Y PR + + AHEAIRPT T
Sbjct: 309 GVTLSNDAIADIRKLIDKNYGNQYLPIKPRIYQSKVKNAQEAHEAIRPTNITYTPD---- 364
Query: 1013 IRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVE----VEGY 1068
+L + L KD+++LY+LI+ R IA QM+ V+ + I + + E G
Sbjct: 365 ------SLKQKLEKDYYKLYELIWHRTIACQME--NVIMDLVIANLASENKEYLAKANGS 416
Query: 1069 IEILYDGWSRVKPLPL--------KQIPKLEKGQKLKVTEI---KQWRAPKVSLYTQGDV 1117
I I +DG+ +V L K +P L++ + +K E+ K + P Y++ +
Sbjct: 417 I-IAFDGFYKVYRESLDDEDEEDNKMLPPLKEQEHIKTKEVIPNKHFTEPP-PRYSEASL 474
Query: 1118 IALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSE 1177
+ ++E GIGRPSTYA I+ L R YV K K+ +P E G V +LV +K V
Sbjct: 475 VKKLEELGIGRPSTYASILSVLQDRKYVALEK--KRFIPEELGRLVTVFLVGFFKKYVEY 532
Query: 1178 ERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS 1214
+ T LE +DEI K +++ L I S
Sbjct: 533 DFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIES 569
>pir||B82870 DNA topoisomerase I UU590 [imported] - Ureaplasma urealyticum
>gi|6899601|gb|AAF31004.1|AE002158_2 (AE002158) DNA
topoisomerase I [Ureaplasma urealyticum]
Length = 677
Score = 197 bits (496), Expect = 6e-49
Identities = 179/633 (28%), Positives = 293/633 (46%), Gaps = 128/633 (20%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L++VESPNK ++I S+ G ++A+ GH+ +L GY
Sbjct: 5 LIVVESPNKIKSIQSYLGD-------------------SYNVIATCGHLRELAKKSGY-- 43
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
D K Y D + + K + K + +K + +LA
Sbjct: 44 ------DPKTY------------DLKWEIIKTTNKKLSKK----------QQIKTIIDLA 75
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVL-SPYTPNIKRIEFHEVTRPAILKAIKEARDINE 819
+ + I + TDPD EGE I+W + ++L +KRI F+E+T+ AILK+I E DI+
Sbjct: 76 KKSNNIYLATDPDREGEAISWHVYDLLPKKDKERVKRITFNEITQKAILKSIDEKHDIDF 135
Query: 820 DRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE---FTESE 876
+ V +Q RRI DR IG++LS + + LSAGRVQ+ L ++V+R E F + E
Sbjct: 136 NLVDSQFARRILDRVIGYKLSGLVKK--NLHGLSAGRVQSIALLFVVERELERRSFVKEE 193
Query: 877 TDFLGLTLENGISITI-------------ENAKGEVKEVEVKDV---------VIEEREI 914
+ +E I +++ +N+ ++K + KD + + I
Sbjct: 194 WYQIEGIIEKNIFVSLRKIPYDVELYNQKDNSDSDLKFLHKKDAQRVIDDLSDIFKVYSI 253
Query: 915 NPLP--------PYTTDAMLQDASRFLGFSATKTMQLAQDLFE--------LGLCTYHRT 958
+ L P TTD +LQ AS G+SA KT +AQ +FE L L TY RT
Sbjct: 254 DDLKITKGDVQLPLTTDKLLQIASNNFGWSANKTTLIAQQMFEGLEINNQQLALITYPRT 313
Query: 959 DSIHVSNTGIEIAKEYISEEIGEEY---FAPRKWGE-----EGAHEAIRPTRPIDTGRLI 1010
DS +S+ ++ A +I G+EY F +K + AHEAI RP+D
Sbjct: 314 DSERLSDDFLQEANAFIENNFGKEYLENFKNKKINRKEVNIQDAHEAI---RPVDINLKP 370
Query: 1011 QLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMK-------PARVLYEKAIISTPFGDV 1063
+ I+D + + D ++LY+L++ + +++ MK R + + T + +
Sbjct: 371 EEIKDYV-------SLDIYKLYNLVWNKTLSALMKVPTFNKQVIRFINNEYKFYTAYKTI 423
Query: 1064 EVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALM 1121
GY + D + + + Q P + G + K +I Q YT+ +IA +
Sbjct: 424 RTLGY--WILDFYKKQRDELEFQPPIINVGDEFKKEKIDLIQKETTPPPYYTEASLIAAL 481
Query: 1122 KERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTR 1181
K G+GRPSTYA + RGY+ K + KL+PTE GIKV Q L + ++S + T
Sbjct: 482 KNAGVGRPSTYATMATIGTTRGYI--NKDKSKLIPTELGIKVIQELKEAFPKVISIKFTS 539
Query: 1182 QLEKIMDEIEEAKADYQEVLRE----LHEEIKR 1210
++E+ +D I K +++++ EE+K+
Sbjct: 540 EMEERLDVIANGKLFWKDLVSTFIPIFEEEVKQ 572
>sp|Q59567|TOP1_MYCTU DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7437432|pir||G70563 DNA
topoisomerase (EC 5.99.1.2) I topA - Mycobacterium
tuberculosis (strain H37RV) >gi|2105048|emb|CAB08843.1|
(Z95436) topA [Mycobacterium tuberculosis]
Length = 934
Score = 196 bits (493), Expect = 1e-48
Identities = 188/629 (29%), Positives = 272/629 (42%), Gaps = 134/629 (21%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KAR +AS+ G G +V +S GH+ DL
Sbjct: 20 LVIVESPTKARKLASYLGS------GYIVE-------------SSRGHIRDLPRAASD-- 58
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVH----DALENVKAM 756
VP ++ W + GV ++ + V +
Sbjct: 59 ------------VPAK----------YKSQPWARLGVNVDADFEPLYIISPEKRSTVSEL 96
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARD 816
R L +VDE+ + TD D EGE IAW + L P P +KR+ FHE+T PAI A + RD
Sbjct: 97 RGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIP-VKRMVFHEITEPAIRAAAEHPRD 155
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE----- 871
++ D V AQ RRI DR G+E+S LW+ + LSAGRVQ+ IV R ++
Sbjct: 156 LDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPK-LSAGRVQSVATRIIVARERDRMAFR 214
Query: 872 -------------------------------------FTESETDFLG--------LTLEN 886
T + D LG + L+
Sbjct: 215 SAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDE 274
Query: 887 GISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQD 946
G S T A + ++ V + P PP+ T + Q+ASR L FSA +TM +AQ
Sbjct: 275 G-SATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQR 333
Query: 947 LFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAP-------RKWGEEGAHEAIR 999
L+E G TY RTDS +S + I A+ + G+EY AP + + AHEAIR
Sbjct: 334 LYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIR 393
Query: 1000 PT-RPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIIST 1058
P T ++ DG N+ D FRLY+LI++R +ASQM AR + I+
Sbjct: 394 PAGETFATPDAVRRELDG-----PNI--DDFRLYELIWQRTVASQMADARGMTLSLRITG 446
Query: 1059 PFGDVEV---------------EGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQ 1103
G EV + Y+E + + +++P L GQ+L + E+
Sbjct: 447 MSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTP 506
Query: 1104 --WRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGI 1161
+ YT+ ++ ++E GIGRPSTY+ I++T+ RGYV K LVP+
Sbjct: 507 DGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYV--HKKGSALVPSWVAF 564
Query: 1162 KVYQYLVSKYKDLVSEERTRQLEKIMDEI 1190
V L + LV + T +E +DEI
Sbjct: 565 AVTGLLEQHFGRLVDYDFTAAMEDELDEI 593
>sp|P57371|TOP1_BUCAI DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|10038959|dbj|BAB12994.1|
(AP001118) DNA topoisomerase I [Buchnera sp. APS]
Length = 861
Score = 195 bits (490), Expect = 3e-48
Identities = 177/628 (28%), Positives = 288/628 (45%), Gaps = 108/628 (17%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
++ +L+IVESP KA+TI + G + +S GH+ DL
Sbjct: 1 MQKSLVIVESPAKAKTINQYLGSE-------------------YIVKSSIGHIRDLTK-- 39
Query: 697 GYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALEN---- 752
G L K+ K + + + +Q G+ P + + L
Sbjct: 40 ---GKLYNKEKNKKFLNENF-----IEKTNENKILIKQMGIDPYQNWKFEYHILPGKEKI 91
Query: 753 VKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIK 812
+ ++ +A +V I + TD D EGE IAW ++ V+ + R+ F+E+T+ +I KA K
Sbjct: 92 ISELKYIANQVKHIYLATDLDREGEAIAWHLKEVIGGDSSKFSRVVFNEITQHSIQKAFK 151
Query: 813 EARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQR---Y 869
IN +RV AQ RR DR +G+ +S LW+ R LSAGRVQ+ + I R
Sbjct: 152 NVGHINMNRVHAQQARRFMDRIVGYMISPLLWKKIA-RGLSAGRVQSVAVRIIADRESII 210
Query: 870 KEFTESETDFLGLTL------------------------ENGISITIENAKGEVKEVEVK 905
K F E L ++L EN +S +E K + VK
Sbjct: 211 KNFVPEEYWKLDVSLISQDKKKINMDVTHYNNKKFRPINENEVSFAVE--KIQKSSCIVK 268
Query: 906 DVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSN 965
+ + + P+ T + Q AS LGFS KTM LAQ L+E G TY RTDS ++S
Sbjct: 269 NYEEKISYLKAPAPFITSTLQQSASLRLGFSVKKTMFLAQKLYEEGYITYMRTDSNYLSE 328
Query: 966 TGIEIAKEYISEEIGEEY-------FAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGII 1018
I+ ++YI G Y ++ K +E AHEAIRP+ I++
Sbjct: 329 YAIKKVRKYIKSNYGSNYLPKEPNIYSNEKHSQE-AHEAIRPSD-------IKI------ 374
Query: 1019 TLPRNLTKDHF-----RLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIE--I 1071
+N+ DH +LY+LI+ +F+ASQMK + K+I T D+ E +
Sbjct: 375 ---KNIDSDHLNSSAKKLYELIWNQFLASQMKSVKY---KSITVTVLADMFKLQKSERIV 428
Query: 1072 LYDGWSRV---KPLPLKQIPKLEKGQKL---KVTEIKQWRAPKVSLYTQGDVIALMKERG 1125
++ GW++V + Q P L+ G +L KVT +++ P +++ ++ ++++G
Sbjct: 429 MFQGWNKVLIEEKNVFSQFPILQTGSQLFINKVTPSQKFTKPP-PRFSEASLVRELEKKG 487
Query: 1126 IGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSK-YKDLVSEERTRQLE 1184
IGRPSTY+ I + RGYV K +K EK ++ + K + +L+ T +E
Sbjct: 488 IGRPSTYSAITSKIQDRGYV---KIKKNKFYAEKMGEILTIRLKKSFSNLIDYNFTAHME 544
Query: 1185 KIMDEIEEAKADYQEVLRELHEEIKRYI 1212
K +D++ E K ++ +L + ++ +
Sbjct: 545 KKLDQVAENKVTWRYLLDDFFKKFSEQL 572
>pir||H81749 DNA topoisomerase I TC0012 [imported] - Chlamydia muridarum (strain
Nigg) >gi|7190053|gb|AAF38905.1| (AE002270) DNA
topoisomerase I [Chlamydia muridarum]
Length = 865
Score = 192 bits (484), Expect = 1e-47
Identities = 178/638 (27%), Positives = 303/638 (46%), Gaps = 135/638 (21%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
+K +L+IVESP K +T+ ++ +GE ++ S+G H+ DL +
Sbjct: 1 MKKSLIIVESPAKIKTL--------RKLLGEGFIFDSSLG-----------HIVDL-PAK 40
Query: 697 GYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAM 756
G+ G+ I K ++P Y Q ++ +++ + C
Sbjct: 41 GF-GIDIEKG-----FIPDY-----------QILEGKEEVIRKICAE------------- 70
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARD 816
A + D + + DPD EGE IAW I N L P I+RI F+ +T+ A+ +A+K R+
Sbjct: 71 ---AKKCDVVYLAPDPDREGEAIAWHIANQL-PKNTKIQRISFNAITKGAVTEALKHPRE 126
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFEN-RNLSAGRVQTPVLGWIVQR---YKEF 872
I+ V AQ RR DR +G+++S L + +SAGRVQ+ L +V R ++F
Sbjct: 127 IDMALVNAQQARRFLDRIVGYKISPILGRKLQRWSGVSAGRVQSVALKLVVDREYAIEQF 186
Query: 873 TESETDFLGLTLENGIS-----ITIENAKGEVKEVEV------KDVVI------------ 909
E + + L++ S + + G+ E E+ +DVV+
Sbjct: 187 VPVEFWNIRVNLQDPKSQKTFWAHLHSVNGKKWEKEIPEGKSSEDVVLIDSKEKADDLVS 246
Query: 910 --------------EEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE------ 949
+E++ N PP+ T + Q+ASR FS+++TM +AQ L+E
Sbjct: 247 LLESATYCVDRVESKEKKRNAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYEGVDLDS 306
Query: 950 ---LGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEY-------FAPRKWGEEGAHEAIR 999
+GL TY RTDS+ I+ ++YI G+EY +A +K ++ AHEAIR
Sbjct: 307 QGAVGLITYMRTDSVRTDPEAIKQVRKYIENHFGKEYVPSSPNMYATKKMAQD-AHEAIR 365
Query: 1000 PTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPA-------RVLYE 1052
PT + L + I T LT+D ++LY LI++RF+ASQM A ++
Sbjct: 366 PTD-------VSLSPESIRT---KLTEDQYKLYSLIWKRFVASQMIAAIYDTLAIQIATN 415
Query: 1053 KAIISTPFGD-VEVEGYIEILYDGWSRVKPLPLK-QIPKLEKGQKLKVTEI--KQWRAPK 1108
K I G ++ +G++ + + Q+PKL + +LK EI +Q
Sbjct: 416 KGIDLRATGSCLKFKGFLAVYEEKRDEEGDEDENIQLPKLHERDELKKEEIEAEQSHTKP 475
Query: 1109 VSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLV 1168
+ +T+ ++ +++ GIGRPSTYA I+ + R Y + K ++L PTE G V Q+L
Sbjct: 476 LPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTL--KEGQRLRPTELGKVVCQFLE 533
Query: 1169 SKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHE 1206
+ + ++ T ++E ++ I + K ++++L+E E
Sbjct: 534 TNFPRIMDIGFTAKMEDELELIADNKKPWKQLLQEFCE 571
>pir||G75403 DNA topoisomerase I - Deinococcus radiodurans (strain R1)
>gi|6459127|gb|AAF10943.1|AE001983_4 (AE001983) DNA
topoisomerase I [Deinococcus radiodurans]
Length = 1021
Score = 190 bits (478), Expect = 7e-47
Identities = 187/657 (28%), Positives = 276/657 (41%), Gaps = 159/657 (24%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTT----- 695
L+IVESP KA+TI + GQ Y V +S GH+ DL +
Sbjct: 48 LVIVESPAKAKTIEKYLGQ----------GYAVE---------SSVGHIRDLPRSAADIP 88
Query: 696 EGYHGV------LILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDA 749
E Y G L ++ D +P YV V E+K
Sbjct: 89 EKYKGQAWARLGLDVEHDFQPLYV----------------VSPEKK-------------- 118
Query: 750 LENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILK 809
+ V +R+LA E DEI++ TD D EGE IAW + L P P +KR+ FHE+TR AI
Sbjct: 119 -QKVAQLRKLAAEADEIILATDDDREGESIAWHLYQELKPKVP-VKRMVFHEITREAIQA 176
Query: 810 AIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRY 869
AI R I+ + V+AQ RR DR G+E+S LW + LSAGRVQ+ +V+R
Sbjct: 177 AIAAPRQIDRNLVEAQEARRAVDRLYGYEVSPVLWRKVAPK-LSAGRVQSVATRMLVERE 235
Query: 870 KE-------------------------------FTESE-------TDFLGLT--LENGIS 889
+E TE + DF LT L G
Sbjct: 236 RERMRFVAATWWDVVVTAQALTAQAGEQTFPARLTEVQGERLAAGKDFDPLTGQLRPGAG 295
Query: 890 ITI----------ENAKGEVKEVEVKDVVIEEREINPLP--PYTTDAMLQDASRFLGFSA 937
+ + E KG+ +K + EE+ P P+ T + Q+ SR L SA
Sbjct: 296 VRLLGEAEALAISEGLKGQT----LKVLTAEEKPFTSRPPAPFITSTLQQEGSRKLRMSA 351
Query: 938 TKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAP-------RKWG 990
TM+ AQ L+E G TY RTDS ++S+ + A+ + + G Y +P +
Sbjct: 352 QTTMRTAQRLYEGGYITYMRTDSTNLSSEAVNAARGQVKDMYGAPYLSPQPRVYAKKSKN 411
Query: 991 EEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVL 1050
+ AHEAIRP T R + +R L+ D +RLYDLI++R +ASQM AR
Sbjct: 412 AQEAHEAIRPAG--STFRTPEQLRG-------ELSGDEWRLYDLIWKRTVASQMSDARGR 462
Query: 1051 YEKAIISTPFGDVEVEGYIEILYDGWSRVKPLP--------------------LKQIPKL 1090
+ + + + ++ + R P +P L
Sbjct: 463 SLRVRLGGQTASGQTADSVPVVLNASGRTIDFPGFLRAYVEGSDDPAAALEDRDTPLPPL 522
Query: 1091 EKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIET 1148
+ G ++ ++K + YT+ ++ ++ GIGRPSTYA I+ T+ RGY +
Sbjct: 523 KXGDAVRAQDVKAEDHETQPPARYTEASLVQALEGAGIGRPSTYASILGTIQDRGYAL-- 580
Query: 1149 KGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELH 1205
K LVP+ L + LV + T ++E+ +DEI + LR +
Sbjct: 581 KKGTALVPSWTAFATSALLEHHFGTLVDYDFTAKMEEDLDEIAGGREHRVPYLRRFY 637
>sp|O69548|TOP1_MYCLE DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|3097241|emb|CAA18818.1|
(AL023093) DNA topoisomerase I [Mycobacterium leprae]
Length = 947
Score = 188 bits (472), Expect = 4e-46
Identities = 187/630 (29%), Positives = 271/630 (42%), Gaps = 136/630 (21%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KAR ++ + G AY V +S GH+ DL T
Sbjct: 18 LVIVESPTKARKLSGYLGS----------AYIVE---------SSRGHIRDLPRTAAD-- 56
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVH----DALENVKAM 756
+ K +P W + GV ++ + V +
Sbjct: 57 -VPAKFKSEP---------------------WARLGVNVDADFEPLYIITPEKKSTVTEL 94
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARD 816
+ L VDE+ + TD D EGE IAW + L P P +KR+ FHE+T AIL A R+
Sbjct: 95 KGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVP-VKRMVFHEITEHAILAAAAHPRE 153
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEF---- 872
++ D V AQ RRI DR G+E+S LW+ + LSAGRVQ+ IVQR ++
Sbjct: 154 LDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPK-LSAGRVQSVATRIIVQRERDRMAFC 212
Query: 873 ------------------TESETDFLG-LTLENGISITIENAKG---------EVKEVEV 904
T F+ LT +G+ + G EV ++ V
Sbjct: 213 SAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIV 272
Query: 905 KD-----------------VVIEEREI---NPLPPYTTDAMLQDASRFLGFSATKTMQLA 944
D V E ++ P PP+ T + Q+A R L FSA +TM +A
Sbjct: 273 LDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIA 332
Query: 945 QDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYF--APRKW-----GEEGAHEA 997
Q L+E G TY RTDS +S + I A+ + GEEY +PR++ + AHEA
Sbjct: 333 QRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEA 392
Query: 998 IRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIIS 1057
IRP G D + L D FR+Y+L++RR +ASQM AR I
Sbjct: 393 IRP-----AGETF-ATPDAVC---NELDGDEFRIYELVWRRTVASQMADARGTTLSLRIE 443
Query: 1058 TPFGDVEV---------------EGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIK 1102
G+ V + Y+E + + +++P L GQ L V ++
Sbjct: 444 GRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLT 503
Query: 1103 Q--WRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKG 1160
+ YT+ ++ ++E GIGRPSTY+ I++T+ RGYV + KG LVP+
Sbjct: 504 PDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYV-QKKG-SALVPSWVA 561
Query: 1161 IKVYQYLVSKYKDLVSEERTRQLEKIMDEI 1190
V L + LV + T +E +DEI
Sbjct: 562 FAVTGLLEQHFGRLVDYDFTAAMEDELDEI 591
>pir||D72038 DNA topoisomerase I CP1103 [imported] - Chlamydophila pneumoniae
(strains CWL029 and AR39) >gi|4377077|gb|AAD18907.1|
(AE001658) DNA Topoisomerase I-Fused to SWI Domain
[Chlamydophila pneumoniae CWL029]
>gi|7190015|gb|AAF38871.1| (AE002266) DNA topoisomerase I
[Chlamydophila pneumoniae AR39]
>gi|8979142|dbj|BAA98977.1| (AP002547) DNA topoisomerase
I-fused to SWI domain [Chlamydophila pneumoniae J138]
Length = 871
Score = 188 bits (472), Expect = 4e-46
Identities = 181/643 (28%), Positives = 286/643 (44%), Gaps = 151/643 (23%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
+K +L+IVESP K +T+ G +S GH+ DL E
Sbjct: 1 MKKSLIIVESPAKIKTLQKLLGSE-------------------FVFASSIGHIVDLPAKE 41
Query: 697 GYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAM 756
G+ D H F Q V P D E + +
Sbjct: 42 --FGI----------------------DVDHDFEPQYQ--VLP--------DKQEVINHI 67
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARD 816
R+LA + +++ + DPD EGE IAW I N L P +P I+R+ F+ +T+ A+ +A+K R
Sbjct: 68 RKLAAKCEKVYLSPDPDREGEAIAWHIANQL-PDSPLIQRVSFNAITKNAVTEALKHPRT 126
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN-LSAGRVQTPVLGWIVQRYKEFT-- 873
I+ V AQ RR+ DR +G+++S L + R+ +SAGRVQ+ L +V R K
Sbjct: 127 IDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIDAF 186
Query: 874 ----------------------------------------ESETDFLGLTLENGI---SI 890
++E D L + E +
Sbjct: 187 VPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEKARHYAE 246
Query: 891 TIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE- 949
+E + + VE K +R P PP+ T + Q+ASR FSA++TM +AQ L+E
Sbjct: 247 LLEKSSYTITRVEAK----AKRRFAP-PPFITSTLQQEASRHFRFSASRTMSIAQTLYEG 301
Query: 950 --------LGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPR------KWGEEGAH 995
GL TY RTDS+ V + +EYI + G+EY + K + AH
Sbjct: 302 VDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAH 361
Query: 996 EAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEK-A 1054
EAIRPT I L D L L+ D F++Y+LI++RF+ASQ+ PA +Y+ A
Sbjct: 362 EAIRPTD-------INLTPD---KLKNKLSDDQFKVYNLIWKRFVASQITPA--IYDTLA 409
Query: 1055 IISTPFGDVEVEGYIEIL-YDGWSRVKPLPLKQ-----------IPKLEKGQKLKVTEIK 1102
+ T ++++ +L + G+ V KQ +P L L E+
Sbjct: 410 VQITTDTEIDLRASGSLLKFKGFLAV--YEEKQDDENDQEEDHPLPPLHAQDALIKEEVS 467
Query: 1103 QWRA--PKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKG 1160
Q +A + +T+ ++ +++ GIGRPSTYA I+ + R Y TK ++L PTE G
Sbjct: 468 QEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYT--TKENQRLRPTELG 525
Query: 1161 IKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRE 1203
+ Q+L + + ++ T +E ++ I + K ++ +L+E
Sbjct: 526 KIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQE 568
>sp|P47368|TOP1_MYCGE DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|1361497|pir||E64213 DNA
topoisomerase (EC 5.99.1.2) - Mycoplasma genitalium
>gi|3844712|gb|AAC71340.1| (U39692) DNA topoisomerase I
(topA) [Mycoplasma genitalium]
Length = 709
Score = 185 bits (464), Expect = 3e-45
Identities = 178/654 (27%), Positives = 288/654 (43%), Gaps = 141/654 (21%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+++ESPNK +T+ + PS F++V+T G+
Sbjct: 5 LVVIESPNKVKTLKQYL--PSDE--------------------------FEIVSTVGHIR 36
Query: 701 VLILKDDG--KPYYVPVYDTIKRCRDCGHQFVDW-EQKGVCPKCGSRNVHDALENVKAMR 757
++ K+ G + Y P+++ DW + K PK +++ E +K+++
Sbjct: 37 EMVYKNFGFDENTYTPIWE-------------DWTKNKQKNPK--QKHLLSKFEIIKSIK 81
Query: 758 ELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTP-NIKRIEFHEVTRPAILKAIKEARD 816
A + I + +DPD EGE I+W + ++L KRI F+E+T+ A++ A+K+ R+
Sbjct: 82 AKASDAQNIFLASDPDREGEAISWHVYDLLDQKDKAKCKRITFNEITKKAVVDALKQPRN 141
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESE 876
I+ + V++Q R+I DR IGF LS+ L + + SAGRVQ+ L ++ +R KE +
Sbjct: 142 IDLNWVESQFARQILDRMIGFRLSRLLNSYLQAK--SAGRVQSVALRFLEEREKEIAKFV 199
Query: 877 TDF-----LGLTLENGISITI---------------------------ENAKG-----EV 899
F + L EN + EN G E
Sbjct: 200 PRFWWTVDVLLNKENNQKVVCANKSIPLVLREINPELSASLKLDFEAAENVSGIDFLNEA 259
Query: 900 KEVEVKDVVIEEREI-----------NPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLF 948
+ + E E+ +P P YTT ++ +DA LG+S+ K +AQ L+
Sbjct: 260 SATRFANQLTGEYEVYFIDEPKIYYSSPNPVYTTASLQKDAINKLGWSSKKVTMVAQRLY 319
Query: 949 E--------LGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPR------KWGE--- 991
E L +Y RTDSI +SN ++YI +E G Y A + K E
Sbjct: 320 EGISVNGKQTALISYPRTDSIRISNQFQSECEKYIEKEFGSHYLADKNKLKRHKKDEKII 379
Query: 992 EGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPA---- 1047
+ AHE I PT T L + +D F LY LI+ R +AS M A
Sbjct: 380 QDAHEGIHPTYITITPN----------DLKNGVKRDEFLLYRLIWIRTVASLMADAKTSR 429
Query: 1048 ---RVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKG-----QKLKVT 1099
R + +K T + +GY + + K + KL+ G +K+ V
Sbjct: 430 TIVRFINQKNKFYTSSKSLLFDGYQRLYEEIKPNTKDELYIDLSKLKIGDKFSFEKISVN 489
Query: 1100 EIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEK 1159
E K P+ YTQ +I +++ IGRPSTY + L+RGY + TE
Sbjct: 490 EHKTNPPPR---YTQASLIEELEKSNIGRPSTYNTMASVNLERGYA--NLVNRFFYITEL 544
Query: 1160 GIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIR 1213
G KV L + +++++E T+++EK +DEI E K +YQE L++ K ++
Sbjct: 545 GEKVNNELSKHFGNVINKEFTKKMEKSLDEIAENKVNYQEFLKQFWTNFKSDVK 598
>pir||A75055 DNA topoisomerase I (topa) PAB1430 - Pyrococcus abyssi (strain
Orsay) >gi|5458847|emb|CAB50334.1| (AJ248287) DNA
topoisomerase I (topA) [Pyrococcus abyssi]
Length = 685
Score = 180 bits (453), Expect = 6e-44
Identities = 170/619 (27%), Positives = 281/619 (44%), Gaps = 94/619 (15%)
Query: 641 LMIVESPNKARTIASFFGQ--PSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGY 698
L+I E PN AR IA + P ++ I + YEV K L + ++ GH++ L + +
Sbjct: 3 LVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDF 62
Query: 699 HGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRE 758
G I + P Y+ +N A + +KA+
Sbjct: 63 FGYPIFDIEWVPVYI----------------------------AEKNKDYAKDYIKALSV 94
Query: 759 LALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPN-IKRIEFHEVTRPAILKAIKEARD- 816
LA V E ++ D DTEGE I + P+ KR++F +T+ +L A +
Sbjct: 95 LAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPT 154
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN-----LSAGRVQTPVLGWIVQRYKE 871
IN A + R + D + G LS+ L + + LS GRVQ P L ++V+R +E
Sbjct: 155 INFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVERERE 214
Query: 872 ---FTESETDFLGLTLE-NGISITI----------ENAKGEVKEVE-----VKDVVIEER 912
F + L +E NG + E AK V EV+ V ++ ++ +
Sbjct: 215 IQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQ 274
Query: 913 EINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHV-SNTGIEIA 971
+ NP P+ + ++A GFS KT+ +AQ L+E G +Y RT+S + N +
Sbjct: 275 KRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLI 334
Query: 972 KEYISEEIGEEYFAPRKWG-----------EEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
+ IS +A G E+ AH AI PT G I
Sbjct: 335 IQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPT--------------GEIPG 380
Query: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPA-RVLYEKAIISTPFGDVEVEGYIEILYDGWSRV 1079
P +L+KD +LYD+I RRF+A M+PA R + I++ P + G + GW V
Sbjct: 381 PGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPH-KFMLSG-ARTVKQGWLSV 438
Query: 1080 KPLPLK----QIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKERGIGRPSTYA 1133
+K +P+ G++++V +++ + + + Y+ VI M++ GIG +T A
Sbjct: 439 YGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRA 498
Query: 1134 KIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEA 1193
+I++TL QRGY+ +G+K + T G+KV + L +++S E TR+ E+ MD I +
Sbjct: 499 QILETLYQRGYI---EGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQG 555
Query: 1194 KADYQEVLRELHEEIKRYI 1212
K +EV+ E ++ + +
Sbjct: 556 KLTKEEVIEEAKVKLTKIL 574
>gi|10956714 topoisomerase I [Xylella fastidiosa] >gi|11279673|pir||C82861
topoisomerase I XFa0003 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9112241|gb|AAF85572.1|AE003851_3
(AE003851) topoisomerase I [Xylella fastidiosa]
Length = 660
Score = 180 bits (452), Expect = 8e-44
Identities = 177/623 (28%), Positives = 273/623 (43%), Gaps = 134/623 (21%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
LMI+ESP K +++ G K I AS GH+ DL E G
Sbjct: 3 LMIIESPGKIEKLSTILGDGWK-------------------IAASVGHVRDLPQKE--MG 41
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELA 760
V P + P Y+ +R +GV K ++ L
Sbjct: 42 V------AAPDFKPSYELTER------------GEGVVAK---------------LKNLL 68
Query: 761 LEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINED 820
+ D + + TDPD EGE I+W ++ L P R+ F+E+T A+ ++ R I+
Sbjct: 69 KQADSVYLATDPDREGEAISWHLQQCLKLSNP--LRVTFNEITANAVKASLVAPRTIDVK 126
Query: 821 RVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE--------- 871
RV AQ RR+ DR +G+ +S +L + R LSAGRVQ+P + +V+R +E
Sbjct: 127 RVAAQEARRVLDRLVGYMVSPELSRLTGKR-LSAGRVQSPAVRLVVEREREIKAFKVTNH 185
Query: 872 ------FTESET--DFLGLTLENGISITIEN----------AKGEVKEVEVKDVVIEERE 913
F +++T ++ L + +N A +VK V VK E +
Sbjct: 186 FGAMLFFADAKTSGEWSAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKAVVVKSFDESEAK 245
Query: 914 INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTG---IEI 970
+P PP+TT M Q AS LG M AQ L+E G TYHRTD+ +VS+ I
Sbjct: 246 RSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDIYA 305
Query: 971 AKEYISEEIGEEYFAPRKW----GEEGAHEAIRPT--RPIDTGRLIQLIRDGIITLPRNL 1024
+ +I E+ PRK+ G + H A+ PT + G
Sbjct: 306 VSVKLGLDIAEK---PRKFKAPAGAQVGHPAVTPTHWEVEEAGE---------------- 346
Query: 1025 TKDHFRLYDLIFRRFIASQMKPAR--VLYEKAIISTPFGDVEVEGYIE---ILYDGWSRV 1079
T D LY LI R IA Q+ AR V + + P G VE ++Y GW ++
Sbjct: 347 TSDQKALYKLIRLRAIACQLADARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKL 406
Query: 1080 ------------KPLPLKQIPKLEKGQKLKVT--EIKQWRAPKVSLYTQGDVIALMKERG 1125
+ IP G+ L V ++ + + S YTQ ++ ++ G
Sbjct: 407 IAGDQTEEEDGNEKESSNPIPVCAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLESEG 466
Query: 1126 IGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEK 1185
IGRP+TYA I+ ++ RGYV K K L PTE G + LV K+ + + TR++E+
Sbjct: 467 IGRPATYAAIMDNIVSRGYVKTEK--KYLFPTETGELIVDSLVGKF-EFLDLGFTREIEE 523
Query: 1186 IMDEIEEAKADYQEVLRELHEEI 1208
+D I + ++ Y+ V+ ++H+++
Sbjct: 524 SLDRIAQGESGYKAVIAKVHDQL 546
>pir||A71488 probable DNA topoisomerase I-fused to SWI domain - Chlamydia
trachomatis (serotype D, strain UW3/Cx)
>gi|3329092|gb|AAC68820.1| (AE001335) DNA Topoisomerase
I-Fused to SWI Domain [Chlamydia trachomatis]
Length = 857
Score = 179 bits (449), Expect = 2e-43
Identities = 174/643 (27%), Positives = 294/643 (45%), Gaps = 145/643 (22%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
+K +L+IVESP K +T+ ++ +GE ++ S+G H+ DL +
Sbjct: 1 MKKSLIIVESPAKIKTL--------RKLLGEGFIFDSSLG-----------HIVDL-PAK 40
Query: 697 GYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAM 756
G+ G+ I ++G +VP Y ++ G + V ++ +
Sbjct: 41 GF-GIDI--ENG---FVPDYQILE---------------------GKKEV------IRKI 67
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARD 816
A + D + + DPD EGE IAW I N L P I+RI F+ +T+ A+ +A+K R+
Sbjct: 68 CAEAKKCDVVYLAPDPDREGEAIAWHIANQL-PKDTKIQRISFNAITKGAVTEALKHPRE 126
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFEN-RNLSAGRVQTPVLGWIVQRY------ 869
I+ V AQ RR DR +G+++S L + +SAGRVQ+ L +V R
Sbjct: 127 IDMALVNAQQARRFLDRIVGYKISPILGRKLQRWSGVSAGRVQSVALKLVVDREYAIERF 186
Query: 870 ----------------------------------KEFTESETDFLGLTLENG-----ISI 890
KE E +T + +++ I
Sbjct: 187 VPVEFWNIRVHLKDPQTQKTFWAHLHSVNGKKWEKEIPEGKTSDEVILIDSKEKADEIVA 246
Query: 891 TIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE- 949
+E+A V VE K E++ + PP+ T + Q+ASR FS+++TM +AQ L+E
Sbjct: 247 LLESATYVVDRVESK-----EKKRHAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYEG 301
Query: 950 --------LGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEY-------FAPRKWGEEGA 994
+GL TY RTDS+ ++ ++YI G+E+ +A +K ++ A
Sbjct: 302 VDLDSQGAVGLITYMRTDSVRTDPEAVKQVRKYIEGHFGKEFVPSSPNVYATKKMAQD-A 360
Query: 995 HEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPA------- 1047
HEAIRPT T I+ LT+D ++LY LI++RF+ASQM A
Sbjct: 361 HEAIRPTDVTITPESIR----------SKLTEDQYKLYSLIWKRFVASQMISAIYDTLAI 410
Query: 1048 RVLYEKAIISTPFGD-VEVEGYIEILYDGWSRVKPLPLK-QIPKLEKGQKLKVTEI--KQ 1103
R+ K I G ++ +G++ + + +PKL + L E+ +Q
Sbjct: 411 RITTNKGIDLRATGSCLKFKGFLAVYEEKRDEEGDEEENIHLPKLNERDVLTKEELEAEQ 470
Query: 1104 WRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKV 1163
+ +T+ ++ +++ GIGRPSTYA I+ + R Y + K ++L PTE G V
Sbjct: 471 SHTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTL--KEGQRLRPTELGKVV 528
Query: 1164 YQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHE 1206
Q+L + + ++ T +E ++ I + K ++++L+E E
Sbjct: 529 CQFLETNFPRIMDIGFTAGMEDELELIADNKKPWKQLLQEFCE 571
>pir||E71106 probable DNA topoisomerase I - Pyrococcus horikoshii
>gi|3257028|dbj|BAA29711.1| (AP000003) 686aa long
hypothetical DNA topoisomerase I [Pyrococcus horikoshii]
Length = 686
Score = 179 bits (449), Expect = 2e-43
Identities = 173/621 (27%), Positives = 282/621 (44%), Gaps = 98/621 (15%)
Query: 641 LMIVESPNKARTIASFFGQ--PSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGY 698
L+I E PN AR IA + P K+ + + YE+ K L + ++ GH++ L
Sbjct: 3 LIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKRDV 62
Query: 699 HGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRE 758
G I + +VPVY K G ++ A E +KA+
Sbjct: 63 FGYPIFDIE----WVPVYIAEK-----GKEY-------------------AREYIKALSV 94
Query: 759 LALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNI-KRIEFHEVTRPAILKAIKEARD- 816
LA V E ++ D DTEGE I + P + KR++F +T+ +L A +
Sbjct: 95 LAKRVREFIVACDYDTEGEVIGYTALKYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPT 154
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN-----LSAGRVQTPVLGWIVQRYKE 871
IN A + R I D + G LS+ L + + LS GRVQ P L ++V+R +E
Sbjct: 155 INFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVERERE 214
Query: 872 ---FTESETDFLGLTLE-NGISITIENAKGEVKEVE---------------VKDVVIEER 912
F + L E NG T K ++ E E V +V I+ +
Sbjct: 215 IQSFVPRPYWVIKLIFEKNGQKFTANYEKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQ 274
Query: 913 EINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHV-SNTGIEIA 971
+ P P+ + ++A GFS KT+ +AQ L+E G +Y RT+S + N +
Sbjct: 275 KRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPRNINFRMI 334
Query: 972 KEYISEEIGEEYFAPRKWG-----------EEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
+ +++ +A G E+ AH AI PT G I
Sbjct: 335 IQNLAKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPT--------------GEIPR 380
Query: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPA-RVLYEKAIISTPF------GDVEVEGYIEILY 1073
P +LTKD +LYD+I RRF+A M+PA R + I + P G +G++ + Y
Sbjct: 381 PGDLTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSV-Y 439
Query: 1074 DGWSRVKPLPLKQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKERGIGRPST 1131
+ + + + L P+ G+++KV ++K + + + Y+ VI M++ G+G +T
Sbjct: 440 GKYVKFEEVTL---PEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKAT 496
Query: 1132 YAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIE 1191
A+I++TL QRGY+ +G+K + T G+KV + L +++S E TR+ EK M+ I
Sbjct: 497 RAQILETLYQRGYI---EGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIM 553
Query: 1192 EAKADYQEVLRELHEEIKRYI 1212
E + +EV+ E E + + +
Sbjct: 554 EGRLTKEEVIEEAKERLTKIL 574
>sp|P78032|TOP1_MYCPN DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|2146113|pir||S73898 DNA
topoisomerase I - Mycoplasma pneumoniae (strain ATCC
29342) >gi|1674272|gb|AAB96220.1| (AE000056) DNA
topoisomerase I [Mycoplasma pneumoniae]
Length = 711
Score = 176 bits (441), Expect = 2e-42
Identities = 171/650 (26%), Positives = 290/650 (44%), Gaps = 127/650 (19%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+++ESPNK +T+ + F++V+T G+
Sbjct: 5 LVVIESPNKVKTLQKYLPND-----------------------------FEIVSTIGHIR 35
Query: 701 VLILKDDG--KPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRE 758
++ K+ G + Y PV++ + + +F KG + + + +K+++E
Sbjct: 36 EMVHKNFGFNEADYSPVWEDWTKSKK---KFSSLSFKG---NLKGKKLLSKYDIIKSIKE 89
Query: 759 LALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPN-IKRIEFHEVTRPAILKAIKEARDI 817
A + I + TDPD EGE I+W + +VL + +RI F+E+T+ A+L A+K R+I
Sbjct: 90 KASKATNIYLATDPDREGEAISWHVYDVLDEKDKSKCQRITFNEITKNAVLDALKNPREI 149
Query: 818 NEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESET 877
++ V++Q R+I DR IGF LS+ L + SAGRVQ+ L ++ +R +E
Sbjct: 150 DQSWVQSQFARQILDRMIGFRLSRLLNNYLSAK--SAGRVQSVALRFLEEREQEIRSFVP 207
Query: 878 DF------------------------------------LGLTLENGISIT----IENAKG 897
F GL E S++ ++ A
Sbjct: 208 RFWWTLDVLLNPKAEGVREACANRSIPIVLREINPALRAGLKFEEEKSVSGIDFLDEASA 267
Query: 898 EVKEVEVKDVV----IEERE---INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE- 949
+ ++K V I+E + +P YTT ++ +DA LG+S+ K +AQ L+E
Sbjct: 268 KKFGEQLKGVFEVYNIDETKHYSSSPNSAYTTASLQKDAINKLGWSSKKVTLIAQHLYEG 327
Query: 950 -------LGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPR------KWGE---EG 993
L +Y RTDS +S + KEYI GE+Y + R K GE +
Sbjct: 328 VSINGEQTALISYPRTDSTRLSAQFQQSCKEYILNHYGEKYLSNRIVSAKGKKGEKIIQD 387
Query: 994 AHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEK 1053
AHEAI PT D +++++ I KD F LY LI+ R +AS M + +
Sbjct: 388 AHEAIHPT---DINITPEMVKNAI-------KKDEFLLYRLIWIRTVASLMADCKKSHTH 437
Query: 1054 AIISTPFGDVEVEGYIEILYDGWSRV-KPLPLKQ-------IPKLEKGQKLKVTEIK--Q 1103
G+ +++DG+ ++ + K+ + K+ G + +IK
Sbjct: 438 IRFIND-GNKFYASSKSLVFDGYRKIYEHFENKESNDLYIDLDKIRVGDRFMAKDIKITA 496
Query: 1104 WRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKV 1163
+ + YTQ +I +++ IGRPSTY + L RGY K + T+ G +V
Sbjct: 497 RQTHPAARYTQASLIEALEKSNIGRPSTYNTMASVNLDRGYASLNKHAFHV--TQLGEQV 554
Query: 1164 YQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIR 1213
+ L + ++++E T+ +EK +DEI E K +YQE LR+ K ++
Sbjct: 555 NEELSKHFGKIINKEFTKNMEKSLDEIAENKKNYQEFLRDFWSNFKEEVK 604
>pir||B64506 DNA topoisomerase (EC 5.99.1.2) - Methanococcus jannaschii
>gi|1592234|gb|AAB99673.1| (U67605) DNA topoisomerase I
(topA) {Bacillus subtilis [Methanococcus jannaschii]
Length = 761
Score = 171 bits (429), Expect = 4e-41
Identities = 155/609 (25%), Positives = 278/609 (45%), Gaps = 76/609 (12%)
Query: 637 VKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE 696
+ +AL+I E P+ A+ IA+ G+ K+ I + YE+ K + + ++ GH+F LV E
Sbjct: 4 IMTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKE 63
Query: 697 GYHGVLILKDDGKPYYVPVYDT--IKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVK 754
K+ G + PV+D + D G ++V+ + +K
Sbjct: 64 N-------KEFG---FYPVFDIKWVPASVDKGKEYVN-------------------KYIK 94
Query: 755 AMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA 814
A+++L+ + DE I TD D EGE I + KR+ F +T+ I++A +
Sbjct: 95 ALKKLSKDADEFYIATDWDIEGELIGYHALKYCCG-REKAKRMRFSSLTKKEIVRAFENP 153
Query: 815 RDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN----LSAGRVQTPVLGWIVQR-- 868
+I+ V A R I D + G LS+ L N +S GRVQ P L ++ +R
Sbjct: 154 DEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTEREL 213
Query: 869 -YKEFTESETDFLGLTLENGISITIENAK--------------GEVKEVEVKDVVIEERE 913
K+F + L++ + E K + K +V ++ +R+
Sbjct: 214 EIKKFIPKPYWVIEALLKDNLKAIHEKEKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRK 273
Query: 914 INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKE 973
+ PLPP+ + ++A + S +T ++AQ L+E L +Y RT S + ++
Sbjct: 274 LKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALISYPRTSSQKLPKD-----RK 328
Query: 974 YISE--EIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPR-NLTKDHFR 1030
Y+ + I + + KW E E ++P I I+ +P+ L++
Sbjct: 329 YLEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDPAHPAIH--IVDIPKEELSEKEKE 386
Query: 1031 LYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPL---KQI 1087
+YDLI RR +A+ A Y I ++ G + +GW + P ++
Sbjct: 387 IYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFKLSG-SRTVKEGWHEIYYFPKFDEIEL 445
Query: 1088 PKLEKGQKLKVTEI----KQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRG 1143
P L+K +KV +I K+ + PK YT +I +++RG+G +T A+I+ L++RG
Sbjct: 446 PPLKKNDIIKVEKITITRKETQPPK--RYTVASIIKELEKRGLGTKATRAEIIDKLIKRG 503
Query: 1144 YVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRE 1203
YVI+ K T+ GI V + L +++ E+ TR LE+ +++I+ K +VL E
Sbjct: 504 YVIDDGSLK---VTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLDE 560
Query: 1204 LHEEIKRYI 1212
+ +++ +
Sbjct: 561 AEKRLRKIL 569
>pir||G71870 topoisomerase I - Helicobacter pylori (strain J99)
>gi|4155510|gb|AAD06509.1| (AE001522) topoisomerase I
[Helicobacter pylori J99]
Length = 686
Score = 171 bits (428), Expect = 5e-41
Identities = 143/503 (28%), Positives = 236/503 (46%), Gaps = 67/503 (13%)
Query: 765 EILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA---RDINEDR 821
++ I TDPD EG I + + +I R EF E+T I K ++ A + N
Sbjct: 69 KVYIATDPDREGYAIGYMFYQKIKNVASSIYRAEFFEITPSGINKGLQNALLFENTNRQM 128
Query: 822 VKAQLVRRIEDRWIGFELSQKLWEVF-ENRNLSAGRVQTPVLGWIVQRYKEFTE----SE 876
++ L RR+ D +GF LS L + + + SAGRVQTP L IV R +E + E
Sbjct: 129 YQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREIEKFKALPE 188
Query: 877 TDFLGLTLENGIS------ITIENAKGEVKEVE---------------------VKDVVI 909
+ + ++ I+ +TI++ + +E++ +KD+
Sbjct: 189 NEKVSYQIQAKINDSANREVTIKHCDEKGEEIKFNDKEEALKLFESLKDNKACLLKDLKN 248
Query: 910 EEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIE 969
E P P+ T +L+ AS LG S ++ LAQ+LFE GL TY RTD+ +S ++
Sbjct: 249 SVVETKPKKPFITSTLLEKASSMLGLSISEVQSLAQNLFEAGLITYIRTDAESLSVEFLD 308
Query: 970 IAKEYISEEIGEEY----FAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLT 1025
+ + + + Y + K + AHEAIR T P T L ++ + IT
Sbjct: 309 ETESFYAPIYKDLYLKREYKAGKQSQAEAHEAIRITHPHTTEDLESIVYNANIT-----N 363
Query: 1026 KDHFRLYDLIFRRFIASQMKPARVLYEKA----IISTPFGDVEVEGYIEILYDGWSRVKP 1081
+D +LY LIF R I SQ K A +Y+K I + V+G + K
Sbjct: 364 QDALKLYQLIFERTIESQGKNA--IYDKQDLLFKIKNEYFKCSVKGLKSAGFLAMFSKKE 421
Query: 1082 LPLKQI----PKLEKGQ----KLKVTEI--------KQWRAPKVSLYTQGDVIALMKERG 1125
L + EK Q LK+ ++ + S Y + D + L++ +G
Sbjct: 422 LENDESNDDKDNKEKEQNAQFNLKIDDVLSLNDLVLSTIKRNAPSAYKEADFVKLLENKG 481
Query: 1126 IGRPSTYAKIVQTLLQRGYVIETKGRKKLV-PTEKGIKVYQYLVSKYKDLVSEERTRQLE 1184
IGRPSTYA + TL++R Y+ ++ +K ++ PT KG +V + + Y+ ++ T+Q+E
Sbjct: 482 IGRPSTYASYLPTLVKREYISISQDKKHIITPTHKGKRVVEVFENAYQFIIDLTYTKQME 541
Query: 1185 KIMDEIEEAKADYQEVLRELHEE 1207
+++DEI E K+ Y + + L+ +
Sbjct: 542 EVLDEIVENKSSYVDFISNLNSK 564
>pir||T04488 DNA topoisomerase homolog F8F16.30 - Arabidopsis thaliana
>gi|2827516|emb|CAA16524.1| (AL021633) DNA topoisomerase
like-protein [Arabidopsis thaliana]
>gi|7270023|emb|CAB79839.1| (AL161578) DNA topoisomerase
like-protein [Arabidopsis thaliana]
Length = 1179
Score = 161 bits (403), Expect = 5e-38
Identities = 145/532 (27%), Positives = 229/532 (42%), Gaps = 96/532 (18%)
Query: 745 NVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPY-----TPNIKRIEF 799
++++ L + +R+LA + +++ +DPD EGE IAW I +L + + R+ F
Sbjct: 494 DMYEVLPSYGHIRDLATRAENLILASDPDREGEAIAWHIIEMLQQQGALHESMTVARVVF 553
Query: 800 HEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQT 859
HE+T AI A++ R+I+ D V A L RR D IGF +S LW SAGRVQ+
Sbjct: 554 HEITESAIKSALQSPREIDGDLVHAYLARRALDYLIGFNISPLLWRKLPGCP-SAGRVQS 612
Query: 860 PVLGWIVQRYKE---FTESETDFLGLTLE--------------------NGISITIE-NA 895
L + R E F E +G+ ++ N +SI+ E NA
Sbjct: 613 AALALVCDRESEIDGFKPQEYWTVGIKVKGKDNSATFSAHLTSLNSKRLNQLSISSEANA 672
Query: 896 KGEVKEVE-----VKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFEL 950
+ + ++ VK NP PY T + QDA+ L FS TM++A +
Sbjct: 673 QDIEQRIKSEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFSTAHTMKIADE---- 728
Query: 951 GLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYF--APRKW-----GEEGAHEAIRPTRP 1003
I+ + ++E G+ + +PRK+ + AHEAIRPT
Sbjct: 729 ----------------AIKDIQSLVAERYGKNFTSDSPRKYFKKVKNAQEAHEAIRPT-- 770
Query: 1004 IDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLY---------EKA 1054
D RL T+ L D +LY LI+ R +A QM+PA + E
Sbjct: 771 -DIRRLPS-------TIASLLDADSLKLYTLIWSRAVACQMEPASIAQIQLDIGNASESI 822
Query: 1055 IISTPFGDVEVEGYIEILYD-----------GWSRVKPLPLKQIPKLEKGQKLKV--TEI 1101
I + VE GY + D S + K + L+ G L++ E+
Sbjct: 823 IFRSSCSKVEFLGYQAVYEDPEAKAIKNNDNDQSSEREETFKTLSSLKDGDLLQIGEVEL 882
Query: 1102 KQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGI 1161
KQ Y++G ++ ++E GIGRPSTYA I + L R YV T + L P +
Sbjct: 883 KQHHTQHPPRYSEGSLVKKLEELGIGRPSTYASIFRVLQHRKYV--TIKNRVLYPEFRAR 940
Query: 1162 KVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIR 1213
V +L + ++ T +E +D + +++ +LR+ Y +
Sbjct: 941 MVSAFLTHYFTEITDYSFTADMETELDNVSGGVTEWKGLLRDYWTRFSAYCK 992
>sp|O51768|TOP1_BORBU DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|7437431|pir||C70203 DNA
topoisomerase I (topA) homolog - Lyme disease spirochete
>gi|2688756|gb|AAC67161.1| (AE001180) DNA topoisomerase I
(topA) [Borrelia burgdorferi]
Length = 848
Score = 161 bits (403), Expect = 5e-38
Identities = 159/632 (25%), Positives = 267/632 (42%), Gaps = 132/632 (20%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KA+TI F D+ + A GH+ DL
Sbjct: 6 LIIVESPTKAKTIKKFL-------------------DESFLVEACIGHVVDLPNNA---- 42
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALEN----VKAM 756
K+ K Y + +W + G ++ N V +
Sbjct: 43 ----KEIPKEY----------------KKYEWANISIDYNNGFNPIYIIPSNKKPIVSKL 82
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARD 816
++L ++EI + TD D EGE IA+ ++ VL N KR+ FHE+T AI +++K R+
Sbjct: 83 KKLVKTINEIYLATDQDREGETIAFHLKEVLK--IKNYKRMIFHEITETAITESLKNTRN 140
Query: 817 INEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYK---EFT 873
I+ + V A RRI DR G+ +S LW+ LSAGRVQ+ L ++++ K F
Sbjct: 141 IDMNLVNAGEARRILDRLYGYTISPLLWKKVAY-GLSAGRVQSVGLKLLIEKEKTRINFK 199
Query: 874 ESE--------------------------------TDFLGLT-----------LENGISI 890
++ DF+ T + + I
Sbjct: 200 KANYYSILLQCKHEKKNLLLEAKLEEIDGKNIAEGKDFVNETGKLKNIAKTTIITQDLMI 259
Query: 891 TIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFEL 950
+E +++E+ + ++ +I P P+TT + Q+ ++ L + MQ AQ L+E
Sbjct: 260 ELEKELKNGQKIELISIETKKIKIPPPKPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEH 319
Query: 951 GLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFA------PRKWGEEGAHEAIRPTRPI 1004
G TY RTDS +++ + + I + G+EY ++ + AHEAIRP+
Sbjct: 320 GYITYMRTDSHNIAKIAKDKITKIIKNKYGKEYIEEKDRIYEKEKMAQNAHEAIRPSEIF 379
Query: 1005 DTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPA-------RVLYEKAIIS 1057
I++ +K +Y +I+ R I S MK A Y+ I
Sbjct: 380 IPNETIEI-----------ESKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFR 428
Query: 1058 TPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIK----QWRAPKVSLYT 1113
+ F + +G+++ + + ++KG + ++K + +AP YT
Sbjct: 429 SSFTKIIFDGFLKHTKEQDEHLN----INFDLIKKGDTFSIVKMKTSEHETKAP--FRYT 482
Query: 1114 QGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKD 1173
+ ++ M++ GIGRPSTY+ I+ TLL+R Y K L+PT KG V L +
Sbjct: 483 EASLVQKMEKEGIGRPSTYSTIISTLLEREYAF--KLNNTLMPTIKGAAVINLLEKYFPV 540
Query: 1174 LVSEERTRQLEKIMDEIEEAKADYQEVLRELH 1205
L+ T +E+ +D+I K D + L + +
Sbjct: 541 LIELNFTSNMEEKLDKIAIGKLDKIKYLSKFY 572
>gb|AAF36767.1| (L35043) DNA topoisomerase I [Mycoplasma gallisepticum]
Length = 719
Score = 158 bits (396), Expect = 3e-37
Identities = 172/662 (25%), Positives = 293/662 (43%), Gaps = 143/662 (21%)
Query: 639 SALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVT-TEG 697
S ++++ESPNK +TI + YE I+A+ GH+ DL T G
Sbjct: 6 SKILVIESPNKVKTIKKYLTDD----------YE---------IVATVGHIRDLPKYTLG 46
Query: 698 YHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKA-- 755
++ +D +VP ++ I+ + KG ++ V A++N K
Sbjct: 47 FN-----TED----FVPKWEIIQEKKPA---------KGTSATKKAKTVKKAVKNKKEII 88
Query: 756 --MRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNI---KRIEFHEVTRPAILKA 810
+ + A + DEI + TDPD EGE I+W + +VL N+ KRI F+E++ A+ A
Sbjct: 89 DELVDKAKKADEIYLATDPDREGEAISWHVYDVLKEKGVNVNKCKRIIFNEISEKAVKNA 148
Query: 811 IKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYK 870
I R+I +D V +Q+ RR DR IGF+LS + SAGRVQ+ L +I +R +
Sbjct: 149 IANPREIQKDWVSSQITRRRLDRLIGFKLSSLMKSKINAD--SAGRVQSIALKFITEREE 206
Query: 871 EFTESETDF---LGLTLENGISITI----ENAKGEVKEVEVKDV------VIEEREI--- 914
+ F L + L++G + + E K ++ E+++V E+ E+
Sbjct: 207 LINKFVPRFWWTLDVILKDGTELMLRKIDEKLKDKLGYKELEEVSGIDFNTKEDAELVKQ 266
Query: 915 -------------------NPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFE------ 949
P Y T + QDA L + + K +AQ+L+E
Sbjct: 267 HLSDKYRVYAIDTPKLKSSYPKEVYKTSTLQQDAINKLKWRSMKITSVAQELYEGVTIDD 326
Query: 950 --LGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFA-------------PRKWGEEGA 994
+ L +Y RTDS +S + +++++ G++Y A +K + A
Sbjct: 327 EQIALISYPRTDSTRLSPEYGKTVLDFVAKTYGKDYVATQSQLNGETKANKKQKAKVQDA 386
Query: 995 HEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKA 1054
HEAI PID I + D + ++ D + LY LI+ R +A M A +YE
Sbjct: 387 HEAI---HPID----ISITPDSV---KNKISSDQYSLYKLIWTRTVAHYM--AAAVYE-- 432
Query: 1055 IISTPF-----------GDVEVEGYIEIL--YDGWSRVKPLPLKQIPKLEKGQKLKVTEI 1101
+++ F ++ +GY +I YD ++ L L ++K + K +
Sbjct: 433 LVNIRFINNNNKFYAVNNTLKFDGYKKIYTHYDDKDHLRKLDLNHF-AIDKEFEAKDVLL 491
Query: 1102 KQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGI 1161
+ + + +TQ +I ++ GIGRPSTY+ I+ +L+R Y GR T+ G
Sbjct: 492 NEHQTKPPARFTQATLIEALETEGIGRPSTYSTILDIVLKRNYAELVNGR-YYKTTDLGQ 550
Query: 1162 KVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKA-----------DYQEVLRELHEEIKR 1210
K+ L + ++++E T+ +E +DEI + D+ EVL E I +
Sbjct: 551 KLAFELDKNFPTIINKEFTKNMETTLDEIAQGTVNDVSYLQAFWNDFSEVLNEAKTNIVK 610
Query: 1211 YI 1212
+
Sbjct: 611 KV 612
>pir||H64574 DNA topoisomerase I - Helicobacter pylori (strain 26695)
>gi|2313542|gb|AAD07502.1| (AE000559) DNA topoisomerase I
(topA) [Helicobacter pylori 26695]
Length = 677
Score = 150 bits (374), Expect = 1e-34
Identities = 157/533 (29%), Positives = 225/533 (41%), Gaps = 114/533 (21%)
Query: 765 EILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA---RDINEDR 821
++ I TDPD EG I + + I R EFHE+T I +K A N +
Sbjct: 69 KVYIATDPDREGYGIGYQFYEKIKNVASEIYRAEFHEITPSGIESGLKNAVLFSRSNTNL 128
Query: 822 VKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLG 881
++ L R D+ +GF L+ L + LSAGRVQTP L I QR +E DF
Sbjct: 129 YQSFLGRIASDQVVGFALTSYLRKSLNLSELSAGRVQTPALALICQRDQEIR----DFDK 184
Query: 882 LTLENGISITIE-----------------NAKGEVKEVEVKD------------------ 906
L E + I+ N K E+ + + KD
Sbjct: 185 LDAEEKVEYQIQANIVCNEKEAIIKHVRANEKNELVDFKFKDKNEASQFLKDLKDGLGSM 244
Query: 907 ---VVIEEREIN--PLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSI 961
V ++E N P P+TT +L AS+ L + QLAQ LFE GL TYHRTDS
Sbjct: 245 SVLVSLKESLSNKEPKKPFTTSKLLSQASKSLKIPTKEIAQLAQKLFEAGLITYHRTDSE 304
Query: 962 HVSNTGIEIAKEYISEEIGEEYFAP-------------RKWGEEGAHEAIRPTRPIDTGR 1008
+S EY+ E E +F P K + AHEAIR T P
Sbjct: 305 FLS-------PEYLKEH--EVFFEPIYPSVYQYREYKAGKNSQAEAHEAIRITHPHALKD 355
Query: 1009 LIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLY---------EKAIISTP 1059
L ++ D I+ L +LY LI+ I SQ + A LY +
Sbjct: 356 LEKVCSDAKISEELAL-----KLYQLIYTNTICSQSRNA--LYNQYDCIFKIKSESFKLS 408
Query: 1060 FGDVEVEGYIEI--LYDG---------WSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPK 1108
F ++ +G++EI L G S ++ LK+ LK IK+ P
Sbjct: 409 FKLLKEKGFLEIEELIQGKEEINREEQESEIENFSLKE----NDSVPLKEVFIKKIEKPS 464
Query: 1109 VSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYV-IETKGRKKLVPTEKGIKVYQY- 1166
Y + I L++ GIGRPSTYA + LL+R Y+ I+TK + PT +G++V +
Sbjct: 465 PKPYKESAFIPLLESEGIGRPSTYASFLDLLLKRKYISIDTK-TNAITPTSQGLEVISFF 523
Query: 1167 ----------LVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIK 1209
L SK K + T+Q E+ +D I +A Y++ + E+ ++K
Sbjct: 524 KKDKEVDFIALTSKDKSKLG-NTTKQFEECLDLIMRGEASYEKFMLEVISKLK 575
>sp|P34185|TOP1_SYNP7 DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING
ENZYME) (SWIVELASE) >gi|322050|pir||S32158 DNA
topoisomerase (EC 5.99.1.2) - Synechococcus sp
>gi|288126|emb|CAA51086.1| (X72391) Topoisomerase I
[Synechococcus sp.]
Length = 839
Score = 144 bits (360), Expect = 5e-33
Identities = 162/643 (25%), Positives = 263/643 (40%), Gaps = 145/643 (22%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KARTI ++ K + AS GH+ DL +
Sbjct: 4 LVIVESPTKARTIRNYL-------------------PKDYRVEASMGHVRDLPQSASDIP 44
Query: 701 VLI-------LKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENV 753
+ L D + + P+Y + PK D + V
Sbjct: 45 TELKGEKWSNLGVDVENNFAPLY--------------------IVPK-------DKKKIV 77
Query: 754 KAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKA--- 810
K +++ + DE+++ TD D EG+ I+W + +L P P F E+T+ AI A
Sbjct: 78 KTLKDALKDADELILATDEDREGKVISWHLLQLLQPRCPR-SAWSFDEITQEAIQAAHEK 136
Query: 811 --------IKEARDINED------------------------RVKAQLVRRIEDRWIGFE 838
+ A++ ++D RV++ VR + R
Sbjct: 137 LSGCRSAALVHAQETSQDSRSLGGLHPVGPALEKNCLGPIAGRVQSVAVRLLVQRERARR 196
Query: 839 LSQK--LWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETD-FLGLTLENGISITIENA 895
++ W++ + AG+ + + W + + T ++ D G + ++
Sbjct: 197 AFRQGSYWDLKAQLTVEAGQFEAKL--WTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQ 254
Query: 896 KGEVKEVEVKDV-----VIEEREI---NPLPPYTTDAMLQDASRFLGFSATKTMQLAQDL 947
+ E + D V EE+ N PP+TT + Q+++R L SA +TM++AQ L
Sbjct: 255 EAEALPIRRPDPALASKVAEEKPTHCANQRPPFTTSTLQQESNRKLRLSARETMRVAQSL 314
Query: 948 FELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAP-------RKWGEEGAHEAIRP 1000
+E G TY RTDS+H+S IE A+ + + G+ Y +P + + AHEAIRP
Sbjct: 315 YERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQPRQFTTKSKNAQEAHEAIRP 374
Query: 1001 TRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPAR-----VLYE--- 1052
+T RL Q L+ F +YDLI++R IASQM AR VL E
Sbjct: 375 AG--NTFRLPQ---------ETGLSGAEFAVYDLIWKRTIASQMAEARQTMLSVLLEVDN 423
Query: 1053 -------KAIISTPFGDVEVEGYIE---ILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIK 1102
IS + VEG + L D + + P L + V
Sbjct: 424 AEFAPVASGSISRASSALSVEGSDDPDAALEDPRNSAAGVEGCGSPHLSGTGRESV---- 479
Query: 1103 QWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIK 1162
+ + YT+ ++ +++ GIGRPSTYA I+ T++ RGY L PT
Sbjct: 480 -MKPQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVS--NTLTPTFTAFA 536
Query: 1163 VYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELH 1205
V L + DLV + ++E+ +D+I + D+ L + +
Sbjct: 537 VTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFY 579
>pir||A69084 DNA topoisomerase I - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2622750|gb|AAB86097.1| (AE000921) DNA
topoisomerase I [Methanobacterium thermoautotrophicum]
Length = 718
Score = 140 bits (350), Expect = 8e-32
Identities = 157/618 (25%), Positives = 259/618 (41%), Gaps = 109/618 (17%)
Query: 641 LMIVESPNKARTIA-SFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYH 699
++I E P + IA + F K++ G++ +E GDK +TI+++ GH++ L +
Sbjct: 11 VIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQSNE 70
Query: 700 GVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMREL 759
+ + P+++ K+ KG V D L +R+
Sbjct: 71 EHFFDLE-----WAPIHEIDKK-------------KGY--------VKDYLN---VIRKF 101
Query: 760 ALEVDEILIGTDPDTEGEKIAWDIRNVL--SPYTPNIKRIEFHEVTRPAILKAIKEARDI 817
A D + D D EG I ++ R++F +TR I +A K ++
Sbjct: 102 AAGADRYIHACDYDIEGTLIGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEV 161
Query: 818 NEDRVKAQLVRRIEDRWIGFELSQKLWEVFE---NR--NLSAGRVQTPVLGWIVQRYKEF 872
+ +V + R I D G +S+ L + + NR LSAGRVQTP L +V+R KE
Sbjct: 162 DYGQVDSGAARHILDFIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEI 221
Query: 873 TESE-TDFLGLTLENGISITIENAKGEV---------------KEVEVKDVVIEEREINP 916
+ + + + E G I E+ +G++ + EVKDV + + P
Sbjct: 222 RDFKPVPYWIIRAELGEGIIAESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKP 281
Query: 917 LPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYIS 976
P+ + +A R GFS KT +AQ+L+ G +Y RT S + + I E I
Sbjct: 282 PVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPES---IGYEKIL 338
Query: 977 EEIG---------EEYFAPRK----WGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRN 1023
+ + E P K E+ AH AI PT LP
Sbjct: 339 KNLAKNPRFGVHIERLRGPLKPHEGKKEDDAHPAIHPTG----------------LLPSE 382
Query: 1024 LTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYD-------GW 1076
L+KD ++YDLI RFI+ V E AI+ T ++E+ G E + GW
Sbjct: 383 LSKDEKKVYDLIVHRFIS-------VFGEDAILQTMKVELEI-GEEEFSFSRKRVSKAGW 434
Query: 1077 SRVKP---LPLKQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKERGIGRPST 1131
P + ++ P++ G L V + + + Y + +I ++ RG+G ST
Sbjct: 435 MESYPYTKMEDEEFPEISGGDSLAVRSVSADERETKPPARYNEASLIRELERRGLGTKST 494
Query: 1132 YAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIE 1191
A I+ L R Y+ KK+ + G + L + ++SEE TRQ E+ +++I
Sbjct: 495 RADIIAKLYDRKYI----EGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIM 550
Query: 1192 EAKADYQEVLRELHEEIK 1209
K V+ E E++
Sbjct: 551 RGKISKDRVIDEAITEVR 568
>pir||JC5211 DNA topoisomerase (EC 5.99.1.2) I - Mycobacterium tuberculosis
>gi|1395205|gb|AAC44599.1| (U40159) topoisomerase I
[Mycobacterium tuberculosis]
Length = 900
Score = 123 bits (306), Expect = 1e-26
Identities = 99/300 (33%), Positives = 147/300 (49%), Gaps = 34/300 (11%)
Query: 916 PLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYI 975
P PP+ T + Q+ASR L FSA +TM +AQ L+E G TY RTDS +S + I A+
Sbjct: 308 PYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQA 367
Query: 976 SEEIGE--EYFAPRKW-----GEEGAHEAIRPT-RPIDTGRLIQLIRDGIITLPRNLTKD 1027
+ G+ APR++ + AHEAIRP T ++ DG N+ D
Sbjct: 368 RQLYGDGVRRPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDG-----PNI--D 420
Query: 1028 HFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEV---------------EGYIEIL 1072
FRLY+LI++R +ASQM AR + I+ G EV + Y+E +
Sbjct: 421 DFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETV 480
Query: 1073 YDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQ--WRAPKVSLYTQGDVIALMKERGIGRPS 1130
+ +++P L GQ+L + E+ + YT+ ++ ++E GIGRPS
Sbjct: 481 DELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPS 540
Query: 1131 TYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEI 1190
TY+ I++T+ RGYV K LVP+ V L + LV + T +E +DEI
Sbjct: 541 TYSSIIKTIQDRGYV--HKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEI 598
Score = 97.1 bits (238), Expect = 1e-18
Identities = 78/237 (32%), Positives = 109/237 (45%), Gaps = 54/237 (22%)
Query: 641 LMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHG 700
L+IVESP KAR +AS+ G G +V +S GH+ DL
Sbjct: 26 LVIVESPTKARKLASYLGS------GYIVE-------------SSRGHIRDL-------- 58
Query: 701 VLILKDDGKPYYVPVYDTIKRCRDCGHQFVD--WEQKGVCPKCGSRNVH----DALENVK 754
+ R C ++ W + GV ++ + V
Sbjct: 59 -------------------RGPRRCTRKYKSQPWARLGVNVDADFEPLYIISPEKRSTVS 99
Query: 755 AMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA 814
+R L +VDE+ + TD D EGE IAW + L P P +KR+ FHE+T PAI A +
Sbjct: 100 ELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIP-VKRMVFHEITEPAIRAAAEHP 158
Query: 815 RDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKE 871
RD++ D V AQ RRI DR G+E+S LW+ + LSAGRVQ+ IV R ++
Sbjct: 159 RDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPK-LSAGRVQSVATRIIVARERD 214
>emb|CAC11211.1| (AL445063) DNA topoisomerase III beta related protein [Thermoplasma
acidophilum]
Length = 770
Score = 119 bits (296), Expect = 2e-25
Identities = 136/549 (24%), Positives = 228/549 (40%), Gaps = 72/549 (13%)
Query: 709 KPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENV--KAMRELALEVDEI 766
K Y +P+ I D + DW + + +R V + V + ++ +V+EI
Sbjct: 46 KTYLIPLSGHIVEA-DFESGYSDWNKIDLSDLIDARIVKNIKNKVAYQTLQAFRGKVEEI 104
Query: 767 LIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQL 826
+I TD D EGE I + +++ I+R +F +T+ IL + K +N A
Sbjct: 105 VIATDYDREGELIGVEALDIIKEGKEEIRRAKFSALTKNEILDSFKNLIGVNYSLADAAD 164
Query: 827 VRRIEDRWIGFELSQKLWEVFENR----NLSAGRVQTPVLGWIVQRYKE---FTESETDF 879
R D G L+ + + V R LSAGRVQTP L +V R +E F
Sbjct: 165 ARESIDLIWGSVLT-RFFSVTTGRLGKSFLSAGRVQTPTLAIVVDREREIQSFRPERYWT 223
Query: 880 LGLTLENGISITI---ENAKGE-----------VKEVEVKDVVIEEREINPLPPYTTDAM 925
+ +T + EN K + K V +E I P++T
Sbjct: 224 ISITFDKDGQFKARYPENIKDQDTAEKIYEAIKGKNGRVSSYTSKEDHIRRPAPFSTTEF 283
Query: 926 LQDASRFLGFSATKTMQLAQDLFELGLCTYHRTD------SIHVSNTGIEIAKEYISEEI 979
L++ASR +G TK M +A++L+ GL +Y RTD SI++ + ++ S+ +
Sbjct: 284 LREASR-IGIMPTKAMSIAENLYMRGLISYPRTDNTVYPRSINLKSVLKKLENTAYSKYV 342
Query: 980 GEEYFAPRKWGEEGAHEAI--RPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFR 1037
E R G E P P+D+ + L D+ R+YDLI R
Sbjct: 343 KEIETFDRILPSRGRIETTDHPPIYPVDSPK-------------EQLKGDYGRVYDLILR 389
Query: 1038 RFIASQMKPARVLYEKAIISTPFGDVEVEGYI------EILYDGWSRVKPLPLKQI--PK 1089
F+++ LY + ++ V GY GW+ + K + P+
Sbjct: 390 HFLST-------LYRDGKKTVAEAEIYVNGYTFKAAGQHTTDRGWTEIYGYDPKDVYLPE 442
Query: 1090 LEKGQKLKVTE--IKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIE 1147
L +G+ LK + I++ Y ++ M+E +G ST I+ L++RG++
Sbjct: 443 LTEGEDLKAIDWNIQREETKPPPRYDMSSLLKKMEELNLGTKSTRHDIIGKLIERGFI-- 500
Query: 1148 TKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRE---- 1203
+ PT G+ + S + E T +LE+ MD IE+ + +V+ E
Sbjct: 501 --EGNPVKPTPLGMAFIDAVRSVNSHIADPEMTAKLEEDMDRIEKNEMSKNDVVEESKKM 558
Query: 1204 LHEEIKRYI 1212
LHE + ++
Sbjct: 559 LHEVLSHFL 567
>gi|11499394 DNA topoisomerase I (topA) [Archaeoglobus fulgidus]
>gi|7428459|pir||E69475 DNA topoisomerase I (topA)
homolog - Archaeoglobus fulgidus
>gi|2648740|gb|AAB89443.1| (AE000978) DNA topoisomerase I
(topA) [Archaeoglobus fulgidus]
Length = 663
Score = 118 bits (293), Expect = 4e-25
Identities = 124/495 (25%), Positives = 208/495 (41%), Gaps = 61/495 (12%)
Query: 756 MRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIK--RIEFHEVTRPAILKAIKE 813
++E+A + D + + TD D EGE I + ++ P +K R+ + VT I A +
Sbjct: 91 LKEIAKKADRVTVATDYDREGELIGVEALEIVKSVNPTVKVDRVRYSAVTEKEIRSAFSK 150
Query: 814 ARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN----LSAGRVQTPVLGWIVQR- 868
++ + A L R+ D G L+ +L V R LS GRVQTP L IV R
Sbjct: 151 PVKVDFNLANAALARQKIDLIWGATLT-RLISVHSGRMGKDFLSVGRVQTPTLRLIVDRE 209
Query: 869 -----------YKEFTESETDFLGLTLENGISITIENAKGEVKE-VEVKDVVIEEREINP 916
Y+ F E E G E ++ E +V++ E N
Sbjct: 210 LEIQNFKPEKYYEIFAEFEGFIAKHPKRYGSKEEAEKLFAKIGETAKVEEFTRRRMEENR 269
Query: 917 LPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS---------IHVSNTG 967
P+ T L++AS+F+ S K M +A+ L+ G +Y RTD+ I + +
Sbjct: 270 PTPFNTTEFLREASKFM--SPHKAMNIAETLYMNGYISYPRTDNTVYPPTINLIEIVSAL 327
Query: 968 IEIAKEYISEEIGEEYFAPRKWGEEGA-HEAIRPTRPIDTGRLIQLIRDGIITLPRNLTK 1026
+ + ++ P + E H I PT G L+K
Sbjct: 328 SSVFPREAQIVLSQDKITPSRGRRETKDHPPIYPTGVAKRG---------------ELSK 372
Query: 1027 DHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRV---KPLP 1083
D + +Y+L+ RRF+A+ + P V + ++ G V +++ GW +
Sbjct: 373 DEWTIYELVVRRFLAT-LAPKAVWDVRRVVLDSNGVKFVANGRQLVEAGWRDIYIYSKAE 431
Query: 1084 LKQIPKLEKGQKLKV----TEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTL 1139
++P L+KG L++ E K+ + P Y+ +I +M++ +G ST +I+Q L
Sbjct: 432 ETELPLLKKGDVLRILKKRLEEKETKPP--GRYSASSLIKMMEKLNLGTKSTRHEIIQKL 489
Query: 1140 LQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQE 1199
+ R Y+ R P+E V L + + + T +LE MD I E K E
Sbjct: 490 VSRRYIHGNPFR----PSETAFSVINVLKETAETITLPDMTAKLENEMDLIAEGKKREPE 545
Query: 1200 VLRELHEEIKRYIRS 1214
V+ E E + + +R+
Sbjct: 546 VVDESREMLLQILRA 560
>gb|AAF71288.1|AF255733_1 (AF255733) DNA topoisomerase III alpha [Drosophila melanogaster]
Length = 1250
Score = 114 bits (282), Expect = 7e-24
Identities = 131/499 (26%), Positives = 213/499 (42%), Gaps = 93/499 (18%)
Query: 766 ILIGTDPDTEGEKIAWDIRNVLSPYTPNIK--RIEFHEVTRPAILKAIKEARDINEDRVK 823
++I TD D EGE I ++I +V PNI R F E+T A+ +A+++ ++ +
Sbjct: 135 LIIWTDCDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSD 194
Query: 824 AQLVRRIEDRWIGFELS-------QKLW-EVFENRNLSAGRVQTPVLGWIVQRYKEFTE- 874
A VR D G ++ Q+L+ E ++ +S G Q P LG++ +RYKE
Sbjct: 195 AVDVRTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAF 254
Query: 875 -SETDFLGLTLENGISITIEN--AKGEVKEVE------------------VKDVVIEERE 913
SE + L +T+E A+ + + E V+ V ++ +
Sbjct: 255 VSEPFWKIKVLHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKH 314
Query: 914 INPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKE 973
P T M + SR L SA +TM +A+ L+ G +Y RT++ S KE
Sbjct: 315 KWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTETNQFS-------KE 367
Query: 974 YISEEIGEEYFAPRKWG------------------EEGAHEAIRPTRPIDTGRLIQLIRD 1015
+ + E R WG + AH I PT+
Sbjct: 368 FALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPIHPTK------------- 414
Query: 1016 GIITLPRNLTKDHFRLYDLIFRRFIASQMKPA---RVLYEKAIISTPFGD----VEVEGY 1068
L NL + R+Y+L+ R F+A K A L I F + Y
Sbjct: 415 ----LAENLQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNY 470
Query: 1069 IEI-LYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVS--LYTQGDVIALMKERG 1125
+++ +YD WS KQI E GQ+ + TE+ + L T+ D+IALM++ G
Sbjct: 471 LDVYVYDKWSA------KQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHG 524
Query: 1126 IGRPSTYAKIVQTLLQRGYV-IETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLE 1184
IG +T+A+ + T+ +RGY+ + KG LVP G+ +Y+ + L + + E
Sbjct: 525 IGTDATHAEHINTIKERGYIGVLDKG--FLVPGVIGMGLYEGYDAMELALAKPQLRAEFE 582
Query: 1185 KIMDEIEEAKADYQEVLRE 1203
+ I + + D + VL E
Sbjct: 583 LDLKLICQGQKDPKVVLTE 601
>pir||F71871 topoisomerase I - Helicobacter pylori (strain J99)
>gi|4155496|gb|AAD06496.1| (AE001521) topoisomerase I
[Helicobacter pylori J99]
Length = 425
Score = 112 bits (277), Expect = 3e-23
Identities = 128/469 (27%), Positives = 199/469 (42%), Gaps = 116/469 (24%)
Query: 636 LVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTT 695
+ K+ + I+ESPNK I G + A+GGH +LV
Sbjct: 1 MYKNCVFIIESPNKIAKIKELTGSSF--------------------VFATGGHFVELVNI 40
Query: 696 EGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKA 755
E + K+ + P+++ IK+ D K S +++ + K
Sbjct: 41 E------VNKE-----FNPIFE-IKKSTDK-------------KKDRSTHINHMINQCK- 74
Query: 756 MRELALEVDEIL-IGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEA 814
D+++ I TDPD EG I + + I R EFHE+T+ + K + A
Sbjct: 75 --------DKVVYIATDPDREGYGIGYKFYEKIKNLAKTIYRTEFHEITKSGVEKGLNNA 126
Query: 815 RDINEDRVK---AQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQ---R 868
++ + + L R + D++IGF L+ L + +N + AGRVQTP L +V+ +
Sbjct: 127 GLFSQSNLNLYYSWLGRIVSDQFIGFTLTPYLRKNIKNFEVGAGRVQTPALSILVELDRK 186
Query: 869 YKEFTESETDF-LGLTLE-------NGISITI--ENAKG--EVKEVEVKDVVIEEREINP 916
+ F + D L ++E + ISIT+ EN + E KE+ + + +NP
Sbjct: 187 IQAFEQKNNDEKLSYSIEAIIDALGSQISITLVEENKRKAFETKELAQNFLNDLKNNLNP 246
Query: 917 LP----------------PYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS 960
L P+TT +L+D +R LG + + AQ LFE GL TY RTDS
Sbjct: 247 LAFLDAIEQKDKEKAPPKPFTTSNLLKDGARILGMGVKQIQEHAQKLFEAGLITYIRTDS 306
Query: 961 IHVSNTGIEIAKEYISEEIG------------EEYFAPRKWGEEGAHEAIRPTRPIDTGR 1008
+S KEY+ E EY A + + AHEAIR T P
Sbjct: 307 EALS-------KEYLQEHEAFFEGIYPSVYEYREYRAGKN-SQAEAHEAIRITHPHCYED 358
Query: 1009 LIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIIS 1057
L ++ + IT D ++Y LIF I SQ K A +YE +++
Sbjct: 359 LKKVCEEHNIT-----DIDDLKVYTLIFFNTICSQSKNA--IYENTVLN 400
>sp|O60126|TOP3_SCHPO DNA TOPOISOMERASE III >gi|7490479|pir||T39604 DNA topoisomerase (EC
5.99.1.2) III [similarity] - fission yeast
(Schizosaccharomyces pombe) >gi|4388617|emb|CAA19038.1|
(AL023554) dna topoisomerase iii [Schizosaccharomyces
pombe] >gi|5836087|gb|AAD22485.2| (AF126287)
topoisomerase 3 [Schizosaccharomyces pombe]
Length = 622
Score = 111 bits (276), Expect = 4e-23
Identities = 118/473 (24%), Positives = 207/473 (42%), Gaps = 75/473 (15%)
Query: 743 SRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIK--RIEFH 800
S+N +N+K + A + I TD D EGE I +I NV P+I+ R +F+
Sbjct: 92 SKNAEVLADNIK---KEARNAQYLYIWTDCDREGEHIGVEISNVARASNPSIQVIRADFN 148
Query: 801 EVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELS-------QKLWEVFENRNLS 853
+ R I+ A K RD++++ A R D +G + QK +++ +N+ +S
Sbjct: 149 NLERSHIISAAKRPRDVSKNAADAVDARIELDFRLGAIFTRLQTIQLQKSFDILQNKIIS 208
Query: 854 AGRVQTPVLGWIVQRYKEFTESETD------FLGLTLENGISITIENAKG---------- 897
G Q P LG++V R++ + + F+ I E AK
Sbjct: 209 YGPCQFPTLGFVVDRWQRVEDFVPETYWHLRFVDKRQGKTIQFNWERAKVFDRLTTMIIL 268
Query: 898 ----EVKEVEVKDVVIEER-EINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGL 952
E K +V ++ + + + PLP T + + + + L SA KT++LA++L+ G
Sbjct: 269 ENCLECKTAKVVNITQKPKTKYKPLPLSTVE-LTKLGPKHLRISAKKTLELAENLYTNGF 327
Query: 953 CTYHRTDSIHVSN-----------TGIEIAKEYISEEIGEEYFAPRKWGE-EGAHEAIRP 1000
+Y RT++ + TG + Y + +Y PRK + AH I P
Sbjct: 328 VSYPRTETDQFDSSMNLHAIIQKLTGAQEWDSYAEGLLAGDYRPPRKGKHNDRAHPPIHP 387
Query: 1001 TRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPAR-------VLYEK 1053
+ + L ++DH+++Y+LI RRF+A A+ V E+
Sbjct: 388 VQMVHRSALP--------------SQDHWKVYELITRRFLACCSDNAKGAETLVQVKMEE 433
Query: 1054 AIISTPFGDVEVEGYIEIL-YDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLY 1112
+ S V + Y+E+ Y+ W LP +L + + + ++ S
Sbjct: 434 ELFSKKGLLVTEKNYLEVYPYEKWESSDQLPEY---RLHEEFQPHILDMMDSSTSSPSYI 490
Query: 1113 TQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETK----GRKKLVPTEKGI 1161
T+ ++IALM GIG +T A+ ++ + +R YVI+ K G + VP+ G+
Sbjct: 491 TEPELIALMDANGIGTDATMAEHIEKVQEREYVIKRKKRGQGVTEFVPSSLGV 543
>gb|AAK41190.1| DNA topoisomerase I family A (topA) [Sulfolobus solfataricus]
Length = 668
Score = 109 bits (271), Expect = 1e-22
Identities = 122/491 (24%), Positives = 211/491 (42%), Gaps = 75/491 (15%)
Query: 771 DPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRI 830
D D EG I + I L KR++F +T+ IL A + ++ D + A + R
Sbjct: 112 DYDIEGSVIGYLIIKNLGDIK-KAKRMKFSALTKSDILSAFRNISALDYDMINAGIARHK 170
Query: 831 EDRWIGFELSQKLW---EVFENRN--LSAGRVQTPVLGWIVQRYKE---------FTES- 875
D G +S+ L + F + LSAGRVQ+P L +V E FT S
Sbjct: 171 IDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVSI 230
Query: 876 -------------ETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTT 922
+F +T + N +V EVE + ++E P P T
Sbjct: 231 IVKIKDYSLNIKVNKEFEKITEAKEFLNKLINKTVKVVEVENRVRLLE----RPSPFNLT 286
Query: 923 DAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNT--------GIEIAK-- 972
D + +A R G S ++A+DL+ GL +Y RT+S + +T G+E +
Sbjct: 287 DLQI-EAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTISIYNIIKGLENSSYR 345
Query: 973 ---EYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHF 1029
+ + + G +Y + ++ AH AI PT P+NL F
Sbjct: 346 KLVDLVRKITGGKYVVKQGIKDDPAHPAIHPTG----------------EAPKNLPNSKF 389
Query: 1030 RLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVE---GYIEILYDGWSRVKPLPLKQ 1086
++YDLI RRF+ S A++ I + D +E Y +IL W + +
Sbjct: 390 KIYDLIARRFLGSVSADAKL--SNTIYTLKVSDFPLEFTVSYTKILERNWLDIYHFHNVK 447
Query: 1087 IPK---LEKGQKLKVTE--IKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQ 1141
K L KG + K+ + + + S YT+ ++ M+ +G +T +I++ L++
Sbjct: 448 EDKPIFLSKGDEGKIVDGKVNISLSKPTSRYTKVSLLKWMESSNLGTEATRGRIIEILVK 507
Query: 1142 RGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVL 1201
R Y+ T + ++PT+ G + + L + D+V T +E ++ I+ K +V+
Sbjct: 508 RKYL--TNNGRYIIPTKLGFYIAEILNKFFPDIVDVRMTADMESKLEMIKTGKVLESKVI 565
Query: 1202 RELHEEIKRYI 1212
+E E++ ++I
Sbjct: 566 KENIEKLNKFI 576
>pdb|1CYY|B Chain B, Crystal Structure Of The 30 Kda Fragment Of E. Coli Dna
Topoisomerase I. Hexagonal Form >gi|7245306|pdb|1CYY|A
Chain A, Crystal Structure Of The 30 Kda Fragment Of E.
Coli Dna Topoisomerase I. Hexagonal Form
>gi|7245304|pdb|1CY9|A Chain A, Crystal Structure Of The
30 Kda Fragment Of E. Coli Dna Topoisomerase I.
Monoclinic Form >gi|7245305|pdb|1CY9|B Chain B, Crystal
Structure Of The 30 Kda Fragment Of E. Coli Dna
Topoisomerase I. Monoclinic Form
Length = 264
Score = 106 bits (262), Expect = 2e-21
Identities = 71/223 (31%), Positives = 113/223 (49%), Gaps = 24/223 (10%)
Query: 893 ENAKGEVKEVEVKDVVIEEREINPLP-----PYTTDAMLQDASRFLGFSATKTMQLAQDL 947
E + V +E + ERE P P+ T + Q AS LGF KTM +AQ L
Sbjct: 39 EQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRL 98
Query: 948 FELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYF--APRKW-GEEGAHEAIRPTRPI 1004
+E G TY RTDS ++S + + + YIS+ G++Y +P ++ +E + EA RP
Sbjct: 99 YEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPS 158
Query: 1005 DTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVE 1064
D + + ++D + D +LY LI+R+F+A QM PA+ Y+ ++ GD
Sbjct: 159 DVNVMAESLKD--------MEADAQKLYQLIWRQFVACQMTPAK--YDSTTLTVGAGDFR 208
Query: 1065 VEGYIEIL-YDGWSRVKPLPLKQ-----IPKLEKGQKLKVTEI 1101
++ IL +DGW++V P K +P + KG L + E+
Sbjct: 209 LKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 251
>pir||H72563 probable DNA topoisomerase APE1794 - Aeropyrum pernix (strain K1)
>gi|5105484|dbj|BAA80797.1| (AP000062) 673aa long
hypothetical DNA topoisomerase [Aeropyrum pernix]
Length = 673
Score = 104 bits (258), Expect = 5e-21
Identities = 116/491 (23%), Positives = 210/491 (42%), Gaps = 70/491 (14%)
Query: 771 DPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRI 830
D D EG I + I +R++F + I +A ++ + ++A + R
Sbjct: 103 DYDIEGSVIGFKIIEAFGDVN-RARRMKFSTLAPQDIRRAYARMERLDVEMIEAGMARSE 161
Query: 831 EDRWIGFELSQKLWEVFENRN-----LSAGRVQTPVLGWIVQRYKEFT---ESETDFLGL 882
D G +S+ L E LSAGRVQ+P L +R++E + + +
Sbjct: 162 MDWLWGINVSRALMEAARRAAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKASVAVKI 221
Query: 883 TLENGISI--------------TIENAKGEVKE---VEVKDVVIEEREINPLPPYTTDAM 925
T E G + T + K E+++ + V++V E + P P + +
Sbjct: 222 TAEKGGGVFDARPHGWKPQSLETARSIKSELRKNPWLAVEEVRSERSILRPPPAFNLGDL 281
Query: 926 LQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNT---------------GIEI 970
++A+R LG +T +A++L+ L +Y RT+S + + G E
Sbjct: 282 QKEANRILGLPPLRTQSIAEELYLEALISYPRTNSQKLPPSINYRAILDKLAHGPLGRE- 340
Query: 971 AKEYISEEIGEEYFAPRKWGEEG-AHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHF 1029
A+E + E G P + ++ AH AI PT + RL +K+H
Sbjct: 341 ARELLKETGG--VLRPVQGSKDDPAHPAIHPTGEKPSQRL---------------SKEHM 383
Query: 1030 RLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPL---KQ 1086
+Y+LI RRF+A+ + A V ++ G V + + GW + K
Sbjct: 384 AVYELIVRRFLAAFSREAIVSKSSVLLRDFQGRVWRAEGLRVEDLGWLKYYHYSTPGEKP 443
Query: 1087 IPKLEKGQKLKVTEIK---QWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRG 1143
+P L++G K +V + +W V L + ++ M+ IG T A+I++TL +RG
Sbjct: 444 MPPLDRGDKARVVRVDVRVEWSQTPVRL-DKASLLRWMESVNIGTEGTRARIIETLYKRG 502
Query: 1144 YVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRE 1203
Y+ +G +K T G V + + + +L + TR+ E ++++I + QEV+
Sbjct: 503 YL---EGSRKSEVTPLGEAVAVIIQTLFPELSKPDLTRRFESMIEDIRSGRRTRQEVIDM 559
Query: 1204 LHEEIKRYIRS 1214
+ I + + S
Sbjct: 560 SKKTISKLLES 570
>sp|O96651|TOP3_DROME DNA TOPOISOMERASE III >gi|4235475|gb|AAD13219.1| (AF099909)
topoisomerase III [Drosophila melanogaster]
Length = 875
Score = 100 bits (246), Expect = 1e-19
Identities = 110/488 (22%), Positives = 206/488 (41%), Gaps = 68/488 (13%)
Query: 764 DEILIGTDPDTEGEKIAWDIRNVLSPYTPNIK------RIEFHEVTRPAILKAIKEARDI 817
D +++ D D EGE I +++ + + N+ R F +T I KA++
Sbjct: 110 DYLVLWLDCDKEGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHP 169
Query: 818 NEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN-------LSAGRVQTPVLGWIVQRYK 870
NE+ K+ R+ D IG ++ + F++R +S G QTP LG+ V+R+
Sbjct: 170 NENEAKSVDARQELDLRIGCAFTRFQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHD 229
Query: 871 EF-TESETDFLGLTLENGI-SITIENAKGEV----------------KEVEVKDVVIEER 912
+ T F L L G +T+E A+G V K+ V+ V +E
Sbjct: 230 DIQTFKPESFWHLQLLAGQPEVTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEA 289
Query: 913 EINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS------------ 960
+ T +++ S LG + MQ+A+ L+ G +Y RT++
Sbjct: 290 YKSKPQALNTVELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAV 349
Query: 961 IHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
+HV + +E + I + PRK + G H I P + +
Sbjct: 350 LHVLKPSADFGEE--ARSILGDIQTPRKGKDAGDHPPITPMK---------------LGN 392
Query: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVK 1080
+ +D +R+Y+ I R F+ + + + A +S + ++ G+++V
Sbjct: 393 RSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASV-LIDAGFTKVM 451
Query: 1081 PLPL----KQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKERGIGRPSTYAK 1134
+ P +G ++ + +++ + + T+ ++I LM+E GIG ++
Sbjct: 452 TWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPV 511
Query: 1135 IVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAK 1194
+ + QR YV GR KL+PT GI + +LV ++E+++ I +
Sbjct: 512 HINNICQRNYVHIENGR-KLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGS 570
Query: 1195 ADYQEVLR 1202
A++Q+VLR
Sbjct: 571 ANFQDVLR 578
>gb|AAF46144.1| (AE003437) Top3beta gene product [Drosophila melanogaster]
Length = 875
Score = 100 bits (246), Expect = 1e-19
Identities = 110/488 (22%), Positives = 206/488 (41%), Gaps = 68/488 (13%)
Query: 764 DEILIGTDPDTEGEKIAWDIRNVLSPYTPNIK------RIEFHEVTRPAILKAIKEARDI 817
D +++ D D EGE I +++ + + N+ R F +T I KA++
Sbjct: 110 DYLVLWLDCDKEGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHP 169
Query: 818 NEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN-------LSAGRVQTPVLGWIVQRYK 870
NE+ K+ R+ D IG ++ + F++R +S G QTP LG+ V+R+
Sbjct: 170 NENEAKSVDARQELDLRIGCAFTRFQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHD 229
Query: 871 EF-TESETDFLGLTLENGI-SITIENAKGEV----------------KEVEVKDVVIEER 912
+ T F L L G +T+E A+G V K+ V+ V +E
Sbjct: 230 DIQTFKPESFWHLQLLAGQPEVTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEA 289
Query: 913 EINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDS------------ 960
+ T +++ S LG + MQ+A+ L+ G +Y RT++
Sbjct: 290 YKSKPQALNTVELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAV 349
Query: 961 IHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITL 1020
+HV + +E + I + PRK + G H I P + +
Sbjct: 350 LHVLKPSADFGEE--ARSILGDIQTPRKGKDAGDHPPITPMK---------------LGN 392
Query: 1021 PRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVK 1080
+ +D +R+Y+ I R F+ + + + A +S + ++ G+++V
Sbjct: 393 RSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASV-LIDAGFTKVM 451
Query: 1081 PLPL----KQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMKERGIGRPSTYAK 1134
+ P +G ++ + +++ + + T+ ++I LM+E GIG ++
Sbjct: 452 TWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPV 511
Query: 1135 IVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAK 1194
+ + QR YV GR KL+PT GI + +LV ++E+++ I +
Sbjct: 512 HINNICQRNYVHIENGR-KLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGS 570
Query: 1195 ADYQEVLR 1202
A++Q+VLR
Sbjct: 571 ANFQDVLR 578
>gb|AAC26106.1| (AF042825) DNA topoisomerase I [Pyrococcus furiosus]
Length = 934
Score = 99.1 bits (243), Expect = 3e-19
Identities = 74/219 (33%), Positives = 113/219 (50%), Gaps = 24/219 (10%)
Query: 991 EEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVL 1050
E+ AH AI PT G I P +LTKD LYD+I RRF+A M+PA
Sbjct: 612 EDPAHPAIYPT--------------GEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRE 657
Query: 1051 YEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLK----QIPKLEKGQKLKVTEIKQWR- 1105
K IS + G + +GW RV +K +P G+++KV ++K+ +
Sbjct: 658 TVKVTISAGKHKFFISGG-RTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKK 716
Query: 1106 -APKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVY 1164
+ Y+ VI M++ G+G +T A+I++TL QRGY+ +G+K + T G+KV
Sbjct: 717 KTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYI---EGKKSIKVTPLGMKVI 773
Query: 1165 QYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRE 1203
+ L +++S E TR+ EK M+ I E K +EV+ E
Sbjct: 774 ETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEE 812
>gi|6755851 topoisomerase (DNA) III beta; Topo III beta [Mus musculus]
>gi|6686042|sp|Q9Z321|TP3B_MOUSE DNA TOPOISOMERASE III
BETA-1 >gi|3868800|dbj|BAA34227.1| (AB013603)
topoisomerase III beta [Mus musculus]
Length = 862
Score = 98.3 bits (241), Expect = 5e-19
Identities = 116/521 (22%), Positives = 212/521 (40%), Gaps = 73/521 (14%)
Query: 744 RNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPN-------IKR 796
+ + L VK ++ D +++ D D EGE I +++ + + P N + R
Sbjct: 90 KEANPKLNMVKFLQVEGRGCDYVVLWLDCDKEGENICFEVLDAVLPVMNNAHNGEKTVFR 149
Query: 797 IEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN----- 851
F +T I A+ + + + + R+ D IG ++ + F+ +
Sbjct: 150 ARFSSITDTDICNAMTRLSEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDS 209
Query: 852 --LSAGRVQTPVLGWIVQRYKEFTESETDFLGLT-----LENGISITIENAKGEVKEVEV 904
+S G QTP LG+ V+R+ + + + + + S+ ++ + V + E+
Sbjct: 210 SLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWDRVRVFDWEI 269
Query: 905 KDVVI-----------------EEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDL 947
+ + E+ + PL T + ML+ AS LG MQ+A+ L
Sbjct: 270 AQMFLNMTKLEKEAWVEATSRKEKAKQRPLALNTVE-MLRVASSALGMGPQHAMQIAERL 328
Query: 948 FELGLCTYHRTDSIHV-----------SNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHE 996
+ G +Y RT++ H + + + + E PRK + G H
Sbjct: 329 YTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHP 388
Query: 997 AIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAII 1056
I P + L D +RLY+ I R FIA+ + Y ++ I
Sbjct: 389 PITPMKS---------------ATEAELGGDAWRLYEYITRHFIATVSHDCK--YLQSTI 431
Query: 1057 STPFGDVEVEGYIE-ILYDGWSRVKP---LPLKQ-IPKLEKGQKLKVTEIK--QWRAPKV 1109
S G + ++ G++ + P +PL++ +P +KG V E+K + +
Sbjct: 432 SFRIGPEHFTCMGKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPP 491
Query: 1110 SLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVS 1169
T+ ++I LM++ GIG ++ + + QR YV GR +L PT GI +
Sbjct: 492 DYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGR-RLKPTNLGIVLVHGYYK 550
Query: 1170 KYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKR 1210
+LV +EK ++ I + KADY +VL + KR
Sbjct: 551 IDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKR 591
>dbj|BAB07106.1| (AP001518) DNA topoisomerase III [Bacillus halodurans]
Length = 721
Score = 97.9 bits (240), Expect = 6e-19
Identities = 125/518 (24%), Positives = 216/518 (41%), Gaps = 92/518 (17%)
Query: 762 EVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIK--RIEFHEVTRPAILKAIKEAR--DI 817
EV EI++ D EGE I +R +L K R+ +T+ A++ + + +
Sbjct: 102 EVTEIVMAGDAGREGELI---VRLILKQCRVKKKTSRLWLSSLTKQAVVSGFHQLKSAES 158
Query: 818 NEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNL----SAGRVQTPVLGWIVQRYKEFT 873
E L R D IG +++ + + + + S GRVQTP L IV+R KE
Sbjct: 159 TEPLYHEALSRSCADWLIGMNVTRAYTLLLKKKGVDSLFSTGRVQTPTLALIVKREKEIE 218
Query: 874 ESET---------------DFLGLTLENGISITIENAKGEV-------KEVEVKDVVIEE 911
E+ ++ G+ ++ + + E K+ +V V E
Sbjct: 219 AFESKPFWEVKATFRVQGHEYEGIWHKDRETRLFDQPMAEAIAAFCRGKQGKVTKVKKET 278
Query: 912 REINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIA 971
+ + P + ++ A++ FS KT+ +AQ L+ G +Y RTDS ++ + A
Sbjct: 279 KTLKPPYLFNLSSLQATANKRFTFSPKKTLDVAQKLYVKGHISYPRTDSSFLTAEEGKAA 338
Query: 972 KEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQ--------LIRDGIITLP-- 1021
K + E+ +A P+D L+Q + D +P
Sbjct: 339 KRIVQLLKQEDAYA--------------SLFPLDRDNLLQDRRYVNQSKVTDHYAIIPTD 384
Query: 1022 -----RNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGW 1076
+ L KD LYDLI R+F+A+ M+ A++ Y + + ++L GW
Sbjct: 385 DVPKVQTLAKDEQLLYDLIVRQFLAAHMREAKIAYTEVETLVDERATFLTKGKQLLDQGW 444
Query: 1077 SRVKPLPL----KQIPKLEKG--QKLKVTEIKQWRAPKVSLYTQGDVIALMK-------- 1122
++ L + IP LE+G +K ++++ + S YT+G +I LMK
Sbjct: 445 KQIIGLSKDDKDEDIPPLEEGWTGDVKHADVREGKTKPPSRYTEGQLITLMKTVGKHVED 504
Query: 1123 ---------ERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKD 1173
G+G +T A I+ L R Y IE K + + TEKG + + L
Sbjct: 505 DELEKVLMRTEGLGTEATRAGIITLLKDRQY-IEIK-KNVVYATEKGKLLIEALGPSL-- 560
Query: 1174 LVSEERTRQLEKIMDEIEEAKAD---YQEVLRELHEEI 1208
L S E T + E+ + EI +AD + E +++L + +
Sbjct: 561 LASPEMTAKWEQRLFEIGRGQADAHAFMEQVKKLSDHL 598
>emb|CAB60424.1| (AL117203) predicted using Genefinder~contains similarity to Pfam
domain: PF01131 (Prokaryotic DNA topoisomerase),
Score=255.0, E-value=3.3e-73, N=1; PF01751 (Toprim
domain), Score=44.3, E-value=8.6e-10, N=1 [Caenorhabditis
elegans]
Length = 615
Score = 96.7 bits (237), Expect = 1e-18
Identities = 139/603 (23%), Positives = 259/603 (42%), Gaps = 104/603 (17%)
Query: 668 LVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKD-DGKPYYVPVYDTIKRCRDCG 726
+VA + + D + +L++G +G++GV + + DG+ + K CG
Sbjct: 7 MVAEKPLLADSIANLLSNG----QAKKRKGWNGVCSVSEYDGQ--FNGRAARFKVTSTCG 60
Query: 727 H--------QFVDWEQKGVCPKCGSRNVH-DALENVKAMRELALEV---DEILIGTDPDT 774
H +F +WE+ + +A +K LA E D +++ D D
Sbjct: 61 HVMSLDFPPKFNNWERVDPAELYSAPTQRIEANPKMKMNEFLASEAKNADFLVLWLDCDK 120
Query: 775 EGEKIAWDIRNVLS--------PYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQL 826
EGE I +++ + + + ++ R F +T I A++ +++ +
Sbjct: 121 EGENICFEVIDAVKCAMFKNRQDFMSDVYRAHFSAITEKDIKAAMRNLGRPDQNMSHSVD 180
Query: 827 VRRIEDRWIGFELSQKLWEVFENRN-------LSAGRVQTPVLGWIVQRYKEFTESETDF 879
R+ D IG ++ + F+ + +S G QTP LG+ V R+ + + + +
Sbjct: 181 ARQELDLRIGCSFTRFQTKFFQGKYGDLDSNVISYGPCQTPTLGFCVTRHDQIVQFKPEQ 240
Query: 880 LGL------TLENGISITIENAKGEVKEVEVKDVVI-----------------EEREINP 916
+ T ++G + E +G + + EV V + E R+ P
Sbjct: 241 YWVLKTNFTTSDDGQIFSPEWQRGRIFDAEVARVFVDRIKKCHTGLVLDVSKKEARKERP 300
Query: 917 LPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTD----SIHVSNTG----I 968
T + M + AS LG S + TM +A+ L+ G +Y RT+ S + TG +
Sbjct: 301 CALNTVELM-RVASSSLGMSPSTTMHVAEALYTQGYISYPRTETTAYSANFDLTGTLKIL 359
Query: 969 EIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDH 1028
+++ S + + P+ ++G H I P RP G L+ D
Sbjct: 360 AGDRKWGSVVLADGIKRPKSGVDKGDHPPITPMRPNHGG----------------LSGDM 403
Query: 1029 FRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVE--VEGYIEILYDGWSRVKP-LPLK 1085
R+Y+ + + F+A+ MK + +YE + GD + ++G ++ G++ V P L ++
Sbjct: 404 SRIYEYVSQHFVATLMK--QCVYEVTTVKMSCGDEQFTLQGK-NVVEPGFTAVMPWLSVE 460
Query: 1086 Q---IPKL--EKGQKLKV--TEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQT 1138
+ +PK + G K+++ EI+ T+ ++I LM++ GIG ++ + T
Sbjct: 461 EECSVPKSLQQIGAKIELQNAEIQARETTPPGYLTEAELITLMEKHGIGTDASIPVHINT 520
Query: 1139 LLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKY----KDLVSEERTRQLEKIMDEIEEAK 1194
+ QR YV GR +LVPT G Q LV Y +LV +LE+ ++ + K
Sbjct: 521 ITQRNYVTVESGR-RLVPTRLG----QCLVRGYWKVDPELVLPTMRAELEEQLNLVASGK 575
Query: 1195 ADY 1197
ADY
Sbjct: 576 ADY 578
>gi|4507635 topoisomerase (DNA) III beta; topoisomerase III beta [Homo sapiens]
>gi|11417829|ref|XP_009862.1| topoisomerase (DNA) III
beta [Homo sapiens] >gi|6686033|sp|O95985|TP3B_HUMAN DNA
TOPOISOMERASE III BETA-1 >gi|4102879|gb|AAD01614.1|
(AF017146) DNA topoisomerase III beta [Homo sapiens]
>gi|4321652|gb|AAD15791.1| (AF053082) DNA topoisomerase
III beta [Homo sapiens]
>gi|4768877|gb|AAD29670.1|AF125216_1 (AF125216) DNA
topoisomerase III beta [Homo sapiens]
Length = 862
Score = 96.0 bits (235), Expect = 2e-18
Identities = 121/522 (23%), Positives = 209/522 (39%), Gaps = 75/522 (14%)
Query: 744 RNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYT-------PNIKR 796
+ + L VK ++ D I++ D D EGE I +++ + + P + R
Sbjct: 90 KEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFR 149
Query: 797 IEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN----- 851
F +T I A+ + + + + R+ D IG ++ + F+ +
Sbjct: 150 ARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDS 209
Query: 852 --LSAGRVQTPVLGWIVQRYKEF----------------TESETDFL-----GLTLENGI 888
+S G QTP LG+ V+R+ + T+ + L + I
Sbjct: 210 SLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREI 269
Query: 889 SITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLF 948
+ N KE +V+ +E+ T ML+ AS LG MQ A+ L+
Sbjct: 270 AQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLY 329
Query: 949 ELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFA-------------PRKWGEEGAH 995
G +Y RT++ H K + ++ Y+A PRK + G H
Sbjct: 330 TQGYISYPRTETTHYPENFD--LKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDH 387
Query: 996 EAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAI 1055
I P + L D +RLY+ I R FIA+ + Y ++
Sbjct: 388 PPITPMKSATEAEL---------------GGDAWRLYEYITRHFIATVSHDCK--YLQST 430
Query: 1056 ISTPFG-DVEVEGYIEILYDGWSRVKP---LPLKQ-IPKLEKGQKLKVTEIK--QWRAPK 1108
IS G ++ +L G++ V P +PL++ +P ++G V E+K + +
Sbjct: 431 ISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNP 490
Query: 1109 VSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLV 1168
T+ ++I LM++ GIG ++ + + QR YV GR +L PT GI +
Sbjct: 491 PDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGR-RLKPTNLGIVLVHGYY 549
Query: 1169 SKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKR 1210
+LV +EK ++ I + KADY++VL + KR
Sbjct: 550 KIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKR 591
>dbj|BAA96895.1| (AB019227) DNA topoisomerase III [Arabidopsis thaliana]
Length = 926
Score = 94.8 bits (232), Expect = 5e-18
Identities = 149/648 (22%), Positives = 262/648 (39%), Gaps = 134/648 (20%)
Query: 639 SALMIVESPNKARTIA------SFFGQPSKRRIGELVAYEVSIGDKMLTILASG--GHMF 690
+ L + E P+ A+++A +F + + R ++ ++ +I + +L + GH+
Sbjct: 10 TVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLM 69
Query: 691 DLVTTEGY---HGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVH 747
+L + Y H D Y PV +
Sbjct: 70 ELEFADRYRKWHSC----DPADLYQAPVMKHVPE-------------------------- 99
Query: 748 DALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPN--IKRIEFHEVTRP 805
D + K + E A + D +++ D D EGE IA+++ +V N I+R F +
Sbjct: 100 DKKDIKKTLEEEARKSDWLVLWLDCDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDR 159
Query: 806 AILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQ----KLWEVF--------ENRNLS 853
I +A++ RD N+ +A R+ D IG ++ L + F +R +S
Sbjct: 160 DIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVIS 219
Query: 854 AGRVQTPVLGWIVQRYKEFTESETD-FLGLTL----ENGISITIENAKGEVKE----VEV 904
G Q P LG+IV+RY E E + F + E G++ T +G + + V +
Sbjct: 220 YGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLA-TFNWMRGHLFDYASAVIL 278
Query: 905 KDVVIEE-----------REINPLPPY--TTDAMLQDASRFLGFSATKTMQLAQDLFELG 951
++ +EE RE PPY T + + ASR+ S+ TM++A++L++ G
Sbjct: 279 YEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAG 338
Query: 952 LCTYHRTDSIHVSN-TGIEIAKEYISEEIGEEYFAPRKWGEEG--------------AHE 996
+Y RT++ S+ T + E + +A R EG AH
Sbjct: 339 FISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHP 398
Query: 997 AIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAII 1056
I PT+ +G N ++DH +Y+L+ R ++A +PA V E +
Sbjct: 399 PIHPTK-FSSGE-------------SNWSRDHLNVYELVVRHYLACVSQPA-VAAETTVE 443
Query: 1057 STPFGD--------VEVEGYIEIL-YDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRA- 1106
G+ + + Y+E+ ++ W IP EKGQ+ T + A
Sbjct: 444 IDIAGERFSASGRAILAKNYLEVYRFESWGG------SVIPVYEKGQQFIPTTLTLDAAV 497
Query: 1107 -PKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQ 1165
L + D+++ M + GIG +T ++ LL RGY + + PT G +
Sbjct: 498 TRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATK-DANTRFSPTNLG----E 552
Query: 1166 YLVSKYKDLVSE----ERTRQLEKIMDEIEEAKADYQEVLRELHEEIK 1209
LV Y D+ E +E M+E+ + EVL +++K
Sbjct: 553 ALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMK 600
>pir||H69724 DNA topoisomerase III topB - Bacillus subtilis
>gi|1881236|dbj|BAA19263.1| (AB001488) PROBABLE DNA
TOPOISOMERASE III [Bacillus subtilis]
>gi|2632726|emb|CAB12233.1| (Z99106) DNA topoisomerase
III [Bacillus subtilis]
Length = 727
Score = 94.0 bits (230), Expect = 9e-18
Identities = 130/513 (25%), Positives = 219/513 (42%), Gaps = 79/513 (15%)
Query: 762 EVDEILIGTDPDTEGEKIA-WDIR--NVLSPYTPNIKRIEFHEVTRPAILKAIKEARDIN 818
+V++I+I TD EGE +A W I NV P IKR+ VT AI + ++ R
Sbjct: 96 DVNQIVIATDAGREGELVARWIIEKANVRKP----IKRLWISSVTDKAIKEGFQKLRSGK 151
Query: 819 E-DRVKAQLVRRIEDRWI-GFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTE-S 875
E + + V R E WI G ++ L F N LS GRVQTP L I +R + +
Sbjct: 152 EYENLYHSAVARAEADWIVGINATRALTTKF-NAQLSCGRVQTPTLAMIAKREADIQAFT 210
Query: 876 ETDFLGL-TLENGISITIENAKGE-------------VKEVEVKDVVIEEREINPLPP-- 919
+ G+ +G+++T ++ K + +K ++ K V+ E +
Sbjct: 211 PVPYYGIRAAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFA 270
Query: 920 ---YTTDAMLQDASRFLGFSATKTMQLAQDLFEL-GLCTYHRTDSIHVSNTGIEIAKEYI 975
Y + +DA + GFSA +T+ + Q L+E L TY RTDS +S+ + K+ +
Sbjct: 271 PALYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRL 330
Query: 976 S----EEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRL 1031
+ + +K G + + + D +I +++ +L+ +L
Sbjct: 331 EGMEVKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLS---SLSDKERKL 387
Query: 1032 YDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQ----- 1086
YDLI +RF+A M PA E +I+ G+ + GW V + +
Sbjct: 388 YDLIAKRFLAVLM-PAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQED 446
Query: 1087 -----IPKLEKGQKLKV---TEIKQWRAPKV--------------SLYTQGDVIALMK-- 1122
+P L+KG L V TE P S + QG+ L+K
Sbjct: 447 DRDQTLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTL 506
Query: 1123 --ERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERT 1180
G+G +T A I++ L ++IE KG+ + T KG ++ Q + +DL S T
Sbjct: 507 GETGGLGTVATRADIIEKLF-NSFLIEKKGQDIFI-TSKGKQLLQLVP---EDLKSPALT 561
Query: 1181 RQLEKIMDEIEEAKADYQEVLREL----HEEIK 1209
+ E+ + I K ++++ H+ +K
Sbjct: 562 AEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVK 594
>pir||S45077 hypothetical protein gamma - Streptococcus pyogenes plasmid pDB101
>gi|2145593|pir||S68603 hypothetical protein gamma -
Streptococcus pyogenes plasmid pDB101 and pBT233
>gi|456366|emb|CAA45931.1| (X64695) ORF gamma
[Streptococcus pyogenes] >gi|496506|emb|CAA47083.1|
(X66468) orf gamma [Streptococcus pyogenes]
>gi|496507|emb|CAA47084.1| (X66468) orf gamma'
[Streptococcus pyogenes] >gi|739951|prf||2004266D repS
downstream ORF [Streptococcus pyogenes]
Length = 714
Score = 90.5 bits (221), Expect = 1e-16
Identities = 149/645 (23%), Positives = 269/645 (41%), Gaps = 123/645 (19%)
Query: 639 SALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASG-GHMFDLVTTEG 697
S +++ E P++A A F Q K+ G + D+ T + G GH+ +L
Sbjct: 2 STVILAEKPSQALAYAQAFNQSDKKD-GYFEIKDPLFTDE--TFITFGFGHLVELAEPGN 58
Query: 698 YHGVLI-LKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAM 756
Y K + P + YD + +D G QF K +
Sbjct: 59 YDEKWQNWKLESLPIFPDRYD-FEVAKDKGKQF------------------------KIV 93
Query: 757 RELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPN--IKRIEFHEVTRPAI---LKAI 811
EL + + I++ TD D EGE IAW I + + ++ + KR+ + + + I + +
Sbjct: 94 AELLKKANTIIVATDSDREGENIAWSIIHKANAFSKDKTFKRLWINSLEKDVIRSGFQNL 153
Query: 812 KEARDINEDRVKAQLVRRIEDRWIGFELSQ----KLWEVFENRNLSAGRVQTPVLGWIVQ 867
+ + +AQ R+I D IG S L + S GRVQTP L I Q
Sbjct: 154 QPGMNYYPFYQEAQ-TRQIADWLIGMNASPLYTLNLQQKGVQGTFSLGRVQTPTLYLIFQ 212
Query: 868 RY--------KEFTESET-------DFLGL--------TLENGIS-ITIENAKGEVKEVE 903
R + F E E F G+ T E ++ ++ + AK +E
Sbjct: 213 RQEAIENFKKEPFFEVEASIKVNQGSFKGVLSPTQRFKTQEELLAFVSSKQAKIGNQEGR 272
Query: 904 VKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHV 963
+ DV +E++ N ++ ++ ++ +A++T++ Q L+E L +Y RTD+ +
Sbjct: 273 ITDVQTKEKKTNSPSLFSLSSLQSKVNQLYKATASQTLKAMQGLYEAKLLSYPRTDTPFI 332
Query: 964 SNTGIEIAKE-------YISEEIGEEYFAPRKWGEEGA----HEAIRPTRPIDTGRLIQL 1012
+ K ++ ++ PRK +G+ H AI PT+ + T +
Sbjct: 333 TENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPTESALAK 392
Query: 1013 IRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDV--------- 1063
+ D L R ++Y L+ + +A M LYE+ I T D+
Sbjct: 393 MDD----LQR-------KIYALVVKTTVA--MFLPDYLYEETKIQTKVADLLFQSIGKTP 439
Query: 1064 EVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKV---TEIKQWRAPKVSLYTQGDVIAL 1120
+ EG+ +IL+ ++ + ++ +P + G+ +V + K+ + PK +T+G ++
Sbjct: 440 KQEGW-KILFKQQNKEEKEDVQTLPLVIIGEHAEVDVKSAEKETQPPKA--FTEGTLLTA 496
Query: 1121 MK-----------------ERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKV 1163
MK GIG +T A I++ L Q+ Y+ K KLV TEKG +
Sbjct: 497 MKTAGKTIDDEEAQKILKDTEGIGTEATRASIIEALKQKEYIQVIK--NKLVVTEKGKLL 554
Query: 1164 YQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEI 1208
Q + S++ L S E T + E + +I + + + + + + + I
Sbjct: 555 CQAVESQHL-LTSAEMTAKWETYLKKIGKREGNQENFITNIKKFI 598
>gb|AAC38606.1| (AF007787) type I topoisomerase [Enterococcus faecalis]
Length = 714
Score = 90.1 bits (220), Expect = 1e-16
Identities = 127/534 (23%), Positives = 232/534 (42%), Gaps = 93/534 (17%)
Query: 748 DALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPN--IKRIEFHEVTRP 805
D + K + EL + + I++ TD D EGE IAW I + + ++ + KR+ + + +
Sbjct: 85 DKKKQFKIVAELLKQANTIIVATDSDREGENIAWSIIHKANAFSKDKTYKRLWINSLEKD 144
Query: 806 AI---LKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQ----KLWEVFENRNLSAGRVQ 858
I + ++ + +AQ R+I D IG S L + S GRVQ
Sbjct: 145 VIRSGFQNLQPGMNYYPFYQEAQ-TRQIADWLIGMNASPLYTLNLQQKGVQGTFSLGRVQ 203
Query: 859 TPVLGWIVQRY--------KEFTESET-------DFLGL--------TLENGIS-ITIEN 894
TP L I QR + F E E F G+ T E ++ ++ E
Sbjct: 204 TPTLYLIFQRQEAIENFRKEPFFEVEASIKVNQGSFKGVISPTQRFKTQEELLAFVSSEQ 263
Query: 895 AKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCT 954
AK +E + DV +E++ N ++ ++ ++ +A++T++ Q L+E L +
Sbjct: 264 AKIGNQEGIIADVQTKEKKTNSPSLFSLSSLQSKVNQLYKATASQTLKAMQGLYEAKLLS 323
Query: 955 YHRTDSIHVSNTGIEIAKE-------YISEEIGEEYFAPRKWGEEGA----HEAIRPTRP 1003
Y RTD+ ++ K ++ ++ PRK +G+ H AI PT+
Sbjct: 324 YPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQ 383
Query: 1004 IDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDV 1063
+ T + + D L R ++Y L+ + +A M LYE+ I T D+
Sbjct: 384 VPTESALAKMDD----LQR-------KIYALVVKTTVA--MFLPDYLYEETKIQTKVADL 430
Query: 1064 ---------EVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKV---TEIKQWRAPKVSL 1111
+ EG+ +IL+ ++ + ++ +P + G+ +V + K+ + PK
Sbjct: 431 LFQSIGKTPKQEGW-KILFKQQTKEEEEDVQTLPLVIIGEHAEVDVKSAEKETQPPKA-- 487
Query: 1112 YTQGDVIALMKE-----------------RGIGRPSTYAKIVQTLLQRGYVIETKGRKKL 1154
+T+G ++ MK GIG +T A I++ L Q+ Y+ K KL
Sbjct: 488 FTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIK--NKL 545
Query: 1155 VPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEI 1208
V TEKG + Q + S++ L S E T + E + +I + + + + + + + I
Sbjct: 546 VVTEKGKLLCQAVESQHL-LTSAEMTAKWETYLKKIGKREGNQENFITNIKKFI 598
>sp|O61660|TOP3_CAEEL DNA TOPOISOMERASE III >gi|11270818|pir||T43031 DNA topoisomerase (EC
5.99.1.2) III - Caenorhabditis elegans
>gi|3047013|gb|AAC13567.1| (AF057032) DNA topoisomerase
III [Caenorhabditis elegans]
Length = 759
Score = 86.6 bits (211), Expect = 2e-15
Identities = 121/505 (23%), Positives = 211/505 (40%), Gaps = 77/505 (15%)
Query: 754 KAMRELALEVDEILIGTDPDTEGEKIAWDIRNVL--SPYTPNIKRIEFHEVTRPAILKAI 811
+ +RE A D +++ TD D EGE I +I V S +I R F E+T+ AI +A
Sbjct: 99 QTLREQAQRHDILVVWTDCDREGEAIGAEIVKVCRDSNRRLDIFRARFSEITKAAITRAA 158
Query: 812 KEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENR------------NLSAGRVQT 859
+ ++E V A R D IG ++ NR +S G Q
Sbjct: 159 RNLIRLDEKTVAAVDCRSELDLRIGSAFTRLQTLHLRNRFRDLLGQNDTSQVISYGSCQF 218
Query: 860 PVLGWIVQRYKEFTESETD-FLGLTLENGISI----------------TIENAKGEVKEV 902
P LG++ RYK ++ F L +E+ T++ E K
Sbjct: 219 PTLGFVTDRYKMIENFVSEPFWKLIVEHTRESHKVEFLWDRNRLFDRDTVDILHDECK-- 276
Query: 903 EVKDVVIEEREINPLPPYTTDAMLQDASRFLG-----FSATKTMQLAQDLFELGLCTYHR 957
E K+ +E+ P + A+ LG SA +TMQ+A+ L+ G +Y R
Sbjct: 277 ETKEAHVEKVAKKPKSKWRPQALDTVELEKLGISKLRMSAKQTMQVAEKLYSKGFISYPR 336
Query: 958 TDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGE---EGAHEAIRPTRPIDTGRLIQLIR 1014
T++ + G+ + + ++ WG+ E + P + I
Sbjct: 337 TET-NKFPAGLNLT------PLVQQQTQSNIWGDFANEVLQNGVNPRNGRKSDEAHPPIH 389
Query: 1015 DGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGD---------VEV 1065
T L D +++Y+L+ R F+A + A+ E+ +++ G +
Sbjct: 390 PLKFTEKHQLQGDDWKVYELVVRHFLACVSQDAQ--GEETMVNLTVGTEKFHASGLRIRD 447
Query: 1066 EGYIEI-LYDGWSRVKPLPLKQIPKLEKGQKLKVTEIK--QWRAPKVSLYTQGDVIALMK 1122
GY+++ +Y+ W + +P +G++ E+K + T+ D+I+LM
Sbjct: 448 MGYLKVYVYEKWGN------RLLPTYTEGERFTDFELKIGDGKTQAPDFLTEADLISLMD 501
Query: 1123 ERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDL---VSEER 1179
+ GIG +T+A+ ++ + R Y I + KL+P+ G+ LV Y D+ +S+
Sbjct: 502 KYGIGTDATHAEHIEKIKTREY-IGVRPDGKLIPSFLGLA----LVDGYDDMGFAMSKPD 556
Query: 1180 TR-QLEKIMDEIEEAKADYQEVLRE 1203
R LE + EI + + QEVL E
Sbjct: 557 LRANLEIGLKEICDGRRQKQEVLDE 581
>emb|CAB60518.1| (AL132860) contains similarity to Pfam domain: PF01131 (Prokaryotic
DNA topoisomerase), Score=360.7, E-value=5e-105, N=1;
PF01751 (Toprim domain), Score=65.2, E-value=4.6e-16,
N=1~cDNA EST yk542g3.5 comes from this gene
[Caenorhabditis elegans]
Length = 743
Score = 85.4 bits (208), Expect = 3e-15
Identities = 126/523 (24%), Positives = 217/523 (41%), Gaps = 78/523 (14%)
Query: 737 VCPKCGSRNVHDALENVKA-MRELALEVDEILIGTDPDTEGEKIAWDIRNVL--SPYTPN 793
V GS H E +A ++E A D +++ TD D EGE I +I V S +
Sbjct: 65 VVSSSGSACCHTRDEAHRADIKEQAQRHDILVVWTDCDREGEAIGAEIVKVCRDSNRRLD 124
Query: 794 IKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRN-- 851
I R F E+T+ AI +A + ++E V A R D IG ++ NR
Sbjct: 125 IFRARFSEITKAAITRAARNLIRLDEKTVAAVDCRSELDLRIGSAFTRLQTLHLRNRFRD 184
Query: 852 ----------LSAGRVQTPVLGWIVQRYKEFTESETD-FLGLTLENGISI---------- 890
+S G Q P LG++ RYK ++ F L +E+
Sbjct: 185 LLGQNDTSQVISYGSCQFPTLGFVTDRYKMIENFVSEPFWKLIVEHTRESHKVEFLWDRN 244
Query: 891 ------TIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLG-----FSATK 939
T++ E K E K+ +E+ P + A+ LG SA +
Sbjct: 245 RLFDRDTVDILHDECK--ETKEAHVEKVAKKPKSKWRPQALDTVELEKLGISKLRMSAKQ 302
Query: 940 TMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGE---EGAHE 996
TMQ+A+ L+ G +Y RT++ + G+ + + ++ WG+ E
Sbjct: 303 TMQVAEKLYSKGFISYPRTET-NKFPAGLNLT------PLVQQQTQSNIWGDFANEVLQN 355
Query: 997 AIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAII 1056
+ P + I T L D +++Y+L+ R F+A + A+ E+ ++
Sbjct: 356 GVNPRNGRKSDEAHPPIHPLKFTEKHQLQGDDWKVYELVVRHFLACVSQDAQ--GEETMV 413
Query: 1057 STPFGD---------VEVEGYIEI-LYDGWSRVKPLPLKQIPKLEKGQKLKVTEIK--QW 1104
+ G + GY+++ +Y+ W + +P +G++ E+K
Sbjct: 414 NLTVGTEKFHASGLRIRDMGYLKVYVYEKWGN------RLLPTYTEGERFTDFELKIGDG 467
Query: 1105 RAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVY 1164
+ T+ D+I+LM + GIG +T+A+ ++ + R Y I + KL+P+ G+
Sbjct: 468 KTQAPDFLTEADLISLMDKYGIGTDATHAEHIEKIKTREY-IGVRPDGKLIPSFLGLA-- 524
Query: 1165 QYLVSKYKDL---VSEERTR-QLEKIMDEIEEAKADYQEVLRE 1203
LV Y D+ +S+ R LE + EI + + QEVL E
Sbjct: 525 --LVDGYDDMGFAMSKPDLRANLEIGLKEICDGRRQKQEVLDE 565
>gb|AAG18918.1| (AE004994) DNA topoisomerase I; TopA [Halobacterium sp. NRC-1]
Length = 663
Score = 82.3 bits (200), Expect = 3e-14
Identities = 97/406 (23%), Positives = 156/406 (37%), Gaps = 69/406 (16%)
Query: 852 LSAGRVQTPVLGWIVQRYKEFTESETD-----FLGLTLEN-------------------- 886
+S GRVQ+P L IV + +E + D F L +
Sbjct: 22 ISVGRVQSPTLKLIVDKEREIEAFDPDDYWELFADLRKDQTTFEAQYFYEDPADGTEAER 81
Query: 887 ----GISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQ 942
G + +A + E V V R +P P+ T ++ A LG+SA + M
Sbjct: 82 VWNEGDADAAFDALRQAGEAVVDSVSRRTRTDDPPAPFNTTQFIRAAGS-LGYSAGRAMS 140
Query: 943 LAQDLFELGLCTYHRTD-SIHVSNTGIEIAKEYISEEI---------GEEYFAPRKWGEE 992
+A+DL+ G TY RTD +++ + E + + ++ +P EE
Sbjct: 141 IAEDLYTAGYITYPRTDNTVYPDDLDERDLLEAFQQTVFGDDADSLLDQDRLSPTSGDEE 200
Query: 993 GA-HEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLY 1051
H I PT L++D + +Y+L+ RRF A+ PA +
Sbjct: 201 TTDHPPIHPTTDFPD--------------RNQLSEDEWAVYELVVRRFFATVAAPAEWAH 246
Query: 1052 EKAIISTPFGDVEVEGYIEILYDGWSRVKPL---PLKQIPKLEKGQKLKVT----EIKQW 1104
+ ++ G ++ G+ V P +P +E+G L +T + KQ
Sbjct: 247 LRVTADADGESLKANGK-RLVEAGYHAVYPYYDSSENHVPPVEEGDTLAITDARLDAKQT 305
Query: 1105 RAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVY 1164
+ P+ Y Q +I M+ IG ST ++ L RGY+ R PT V
Sbjct: 306 QPPR--RYGQSRLIETMESMDIGTKSTRHNTIEKLYDRGYIENDPPR----PTTLAEAVV 359
Query: 1165 QYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKR 1210
+ +VSEE T QLE M I + + +V E E + R
Sbjct: 360 EAAEDYADVVVSEEMTSQLEADMTAIADGETTLDDVTTESREMLDR 405
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.320 0.140 0.397
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 433844104
Number of Sequences: 2977
Number of extensions: 18946169
Number of successful extensions: 75573
Number of sequences better than 1.0e-10: 84
Number of HSP's better than 0.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 74891
Number of HSP's gapped (non-prelim): 226
length of query: 1214
length of database: 189,106,746
effective HSP length: 60
effective length of query: 1154
effective length of database: 153,197,526
effective search space: 176789945004
effective search space used: 176789945004
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 170 (70.6 bits)