BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB2430 (pyrE) DE:orotate phosphoribosyl transferase (pyrE)
(182 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|P56814|PYRE_PYRAB OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 355 2e-97
pir||T47129 orotate phosphoribosyltransferase (EC 2.4.2.10) [val... 351 2e-96
sp|O58855|PYRE_PYRHO OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 312 1e-84
sp|Q58509|PYRE_METJA OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 194 5e-49
pir||H69115 probable orotate phosphoribosyltransferase (EC 2.4.2... 180 7e-45
gi|11499330 orotate phosphoribosyl transferase (pyrE) [Archaeogl... 138 5e-32
emb|CAC11204.1| (AL445063) orotate phosphoribosyltransferase [Th... 137 9e-32
pir||T30520 probable orotate phosphoribosyltransferase (EC 2.4.2... 136 1e-31
sp|P31754|PYR5_BOVIN URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNT... 135 3e-31
dbj|BAA19920.1| (D86227) UMP synthase [Homo sapiens] 133 1e-30
gi|4507835 uridine monophosphate synthetase (orotate phosphoribo... 133 1e-30
pir||B70464 probable orotate phosphoribosyltransferase (EC 2.4.2... 133 1e-30
gi|11433324 uridine monophosphate synthetase (orotate phosphorib... 133 1e-30
dbj|BAA19921.1| (D86228) UMP synthase [Homo sapiens] 132 2e-30
dbj|BAA94297.1| (AB029444) Orotidine 5'phosphate decarboxylase-O... 132 3e-30
gb|AAA61256.1| (M36661) orotidine 5'-monophosphate decarboxylase... 132 3e-30
dbj|BAA19923.1| (D86230) UMP synthase [Homo sapiens] 130 9e-30
sp|O08359|PYRE_SULAC OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 124 5e-28
gb|AAF86340.1|AF277455_1 (AF277455) UMP synthase [Nicotiana plum... 123 9e-28
sp|P09556|PYR5_DICDI URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNT... 120 8e-27
pir||S41014 UMP synthase - Caenorhabditis elegans >gi|3874822|em... 120 8e-27
sp|Q42942|PYR5_TOBAC URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNT... 120 1e-26
gb|AAG20258.1| (AE005101) orotate phosphoribosyl transferase; Py... 120 1e-26
gb|AAF86339.1|AF277454_1 (AF277454) UMP synthase [Zea mays] 120 1e-26
dbj|BAA92171.1| (AB031395) UMP synthase 1 [Oryza sativa] >gi|738... 119 2e-26
sp|Q42586|PYR5_ARATH URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNT... 113 1e-24
pir||A70834 probable orotate phosphoribosyltransferase (EC 2.4.2... 113 1e-24
pir||T47606 UMP synthase - Arabidopsis thaliana >gi|7258350|emb|... 113 1e-24
gb|AAK40926.1| Orotate phosphoribosyltransferase (OPRT) (pyrE) [... 109 2e-23
emb|CAB57685.1| (Y18930) orotate phosphoribosyltransferase (OPRT... 109 2e-23
gb|AAF55842.1| (AE003733) r-l gene product [Drosophila melanogas... 109 2e-23
pir||JU0141 UMP synthase - fruit fly (Drosophila melanogaster) 107 8e-23
pir||T33094 probable orotate phosphoribosyltransferase (EC 2.4.2... 105 3e-22
sp|Q01637|PYR5_DROME URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNT... 101 6e-21
pir||B72463 probable orotate phosphoribosyltransferase (EC 2.4.2... 100 2e-20
pir||S76099 probable orotate phosphoribosyltransferase (EC 2.4.2... 99 2e-20
pir||T36540 probable orotate phosphoribosyltransferase (EC 2.4.2... 96 3e-19
sp|P08870|PYRE_SALTY OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 94 1e-18
pdb|1STO| Orotate Phosphoribosyltransferase (Oprtase) (E.C.2.4... 93 2e-18
sp|Q25566|PYR5_NAEGR URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNT... 92 5e-18
sp|P46534|PYRE_BACCL OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 89 2e-17
sp|P00495|PYRE_ECOLI OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 88 6e-17
emb|CAA05335.1| (AJ002318) orotate phosphoribosyltransferase [Rh... 86 2e-16
pir||C75517 orotate phosphoribosyltransferase - Deinococcus radi... 85 4e-16
dbj|BAA98815.1| (AP002547) uridine 5'-monophosphate synthase [Ch... 85 4e-16
pir||B72058 probable orotate phosphoribosyltransferase (EC 2.4.2... 85 6e-16
dbj|BAB06251.1| (AP001515) orotate phosphoribosyltransferase [Ba... 84 8e-16
pir||E82350 orotate phosphoribosyltransferase VC0211 [imported] ... 83 1e-15
emb|CAA24899.1| (V01578) orotate phosphoribosyltransferase (pyrE... 83 2e-15
gb|AAC95453.1| (AF068902) orotate phosphoribosyltransferase PyrE... 83 2e-15
sp|Q9WYG6|PYRE_THEMA OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 83 2e-15
sp|P50587|PYRE_PSEAE OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 82 3e-15
pir||A82981 orotate phosphoribosyltransferase PA5331 [imported] ... 81 7e-15
pir||A81441 probable orotate phosphoribosyltransferase (EC 2.4.2... 80 2e-14
sp|P21846|PYRE_TRIRE OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE... 79 4e-14
pir||H82840 orotate phosphoribosyl transferase XF0153 [imported]... 78 5e-14
pir||H81032 probable orotate phosphoribosyltransferase (EC 2.4.2... 78 6e-14
pir||S44298 probable orotate phosphoribosyltransferase (EC 2.4.2... 78 8e-14
sp|O42767|PYRE_METAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE... 77 1e-13
sp|P41923|PYRE_YARLI OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE... 77 1e-13
sp|P42719|PYRE_RHILT OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 76 2e-13
sp|P77889|PYRE_LACPL OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 76 2e-13
sp|P43855|PYRE_HAEIN OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 76 3e-13
sp|P57622|PYRE_BUCAI OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 74 9e-13
emb|CAA32901.1| (X14795) orotate phosphoribosyltransferase (AA 1... 74 1e-12
sp|P35788|PYRE_COLGR OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE... 74 1e-12
gi|6323530 Orotate phosphoribosyltransferase 1; Ura5p [Saccharom... 74 1e-12
sp|Q59049|APT_METJA ADENINE PHOSPHORIBOSYLTRANSFERASE (APRT) >gi... 74 1e-12
pir||A29459 orotate phosphoribosyltransferase (EC 2.4.2.10) - Po... 73 2e-12
sp|P08309|PYRE_PODAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE... 73 2e-12
emb|CAA46665.1| (X65783) URA5 [Saccharomyces cerevisiae] 73 2e-12
sp|O13474|PYRE_KLULA OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE... 72 4e-12
gi|6323927 Orotate phosphoribosyltransferase 2; Ura10p [Saccharo... 72 5e-12
pir||A30492 orotate phosphoribosyltransferase (EC 2.4.2.10) - Ba... 71 6e-12
sp|O27375|APT_METTH ADENINE PHOSPHORIBOSYLTRANSFERASE (APRT) >gi... 71 6e-12
sp|P18904|PYRE_SORMA OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE... 71 8e-12
sp|P25972|PYRE_BACSU OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (O... 71 8e-12
pir||T40667 orotate phosphoribosyltransferase (EC 2.4.2.10) SPBC... 70 1e-11
emb|CAA36440.1| (X52194) orotate phosphoribosyltransferase [Sacc... 70 2e-11
pir||T45214 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) ... 70 2e-11
gb|AAB61216.1| (U24682) pyrimidine biosynthesis protein E [Enter... 69 2e-11
gb|AAD01747.1| (AF022887) orotidine monophosphate pyrophosphoryl... 69 4e-11
gb|AAD13717.1| (AF022892) orotidine monophosphate pyrophosphoryl... 68 7e-11
gb|AAC62627.1| (AF070928) orotidine-5'-monophosphate pyrophospho... 68 9e-11
>sp|P56814|PYRE_PYRAB OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|7450998|pir||B75089 probable orotate
phosphoribosyltransferase (EC 2.4.2.10) PAB2430
[similarity] - Pyrococcus abyssi (strain Orsay)
>gi|5458527|emb|CAB50015.1| (AJ248286) orotate
phosphoribosyl transferase (pyrE) [Pyrococcus abyssi]
Length = 182
Score = 355 bits (901), Expect = 2e-97
Identities = 182/182 (100%), Positives = 182/182 (100%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI
Sbjct: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT
Sbjct: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAGVS 180
TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAGVS
Sbjct: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAGVS 180
Query: 181 KD 182
KD
Sbjct: 181 KD 182
>pir||T47129 orotate phosphoribosyltransferase (EC 2.4.2.10) [validated] -
Pyrococcus abyssi >gi|5714375|gb|AAD47891.1| (AF058713)
orotate phosphoribosyltransferase [Pyrococcus abyssi]
Length = 182
Score = 351 bits (892), Expect = 2e-96
Identities = 180/182 (98%), Positives = 180/182 (98%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI
Sbjct: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
EYDKVAGPELGAVPI TALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT
Sbjct: 61 EYDKVAGPELGAVPIXTALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAGVS 180
TTGGSVIRA KILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAGVS
Sbjct: 121 TTGGSVIRAPKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAGVS 180
Query: 181 KD 182
KD
Sbjct: 181 KD 182
>sp|O58855|PYRE_PYRHO OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|7450992|pir||B71054 probable orotate
phosphoribosyltransferase (EC 2.4.2.10) PH1128
[similarity] - Pyrococcus horikoshii
>gi|3257545|dbj|BAA30228.1| (AP000005) 186aa long
hypothetical uridine 5'-monophosphate synthase
[Pyrococcus horikoshii]
Length = 186
Score = 312 bits (792), Expect = 1e-84
Identities = 150/182 (82%), Positives = 173/182 (94%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
MK+EL+ LII+ GCIKFGHF+LTSGKESNYYIDIKSLITNPKAL++IAK+IKE++ +L +
Sbjct: 3 MKDELINLIINEGCIKFGHFVLTSGKESNYYIDIKSLITNPKALRIIAKLIKEKAEELNL 62
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
YDK+AGPELGAVPIATALSLET+KPLLI+RKKKKEHGTGK+IEG + GD+VLLVEDVT
Sbjct: 63 NYDKIAGPELGAVPIATALSLETNKPLLIVRKKKKEHGTGKVIEGNVQKGDKVLLVEDVT 122
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAGVS 180
TTGGSVIRAAKIL+EHGA+VVGIFVVVDREEGA+ENIEKEGFK YPLVLVS+LF+AAG+S
Sbjct: 123 TTGGSVIRAAKILREHGADVVGIFVVVDREEGAKENIEKEGFKFYPLVLVSELFKAAGIS 182
Query: 181 KD 182
KD
Sbjct: 183 KD 184
>sp|Q58509|PYRE_METJA OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|2129347|pir||D64438 probable orotate
phosphoribosyltransferase (EC 2.4.2.10) MJ1109
[similarity] - Methanococcus jannaschii
>gi|1592320|gb|AAB99112.1| (U67554) orotate
phosphoribosyl transferase (pyrE) [Methanococcus
jannaschii]
Length = 176
Score = 194 bits (488), Expect = 5e-49
Identities = 97/172 (56%), Positives = 131/172 (75%), Gaps = 3/172 (1%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
K +L+ L+ + GCI+FG FIL SGK+SNYYIDIK TNP+ LKL+ ++I E+ + +
Sbjct: 4 KSKLINLLKEVGCIRFGEFILASGKKSNYYIDIKKATTNPEILKLVGEIIAEQIKDEDV- 62
Query: 62 YDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTT 121
KVAG ELG+VPIATA+S+ KPLLI+RKK K++GT IEGE+ GD+V++VEDVTT
Sbjct: 63 --KVAGVELGSVPIATAVSIIAQKPLLIVRKKPKDYGTKNKIEGELKEGDKVVIVEDVTT 120
Query: 122 TGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
TGGSV++A K ++E+G V +FVVVDR EGA+EN++KE +L PLV V +L
Sbjct: 121 TGGSVLKAVKEIRENGGIVDKVFVVVDRLEGAKENLQKENVELIPLVTVKEL 172
>pir||H69115 probable orotate phosphoribosyltransferase (EC 2.4.2.10) MTH1860
[similarity] - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622996|gb|AAB86326.1| (AE000938)
uridine 5'-monophosphate synthase [Methanobacterium
thermoautotrophicum]
Length = 180
Score = 180 bits (453), Expect = 7e-45
Identities = 89/172 (51%), Positives = 129/172 (74%), Gaps = 4/172 (2%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
++ EL++L+ + ++ G FIL+SG+ES+YY+DIK +T P L +IA++I + +
Sbjct: 9 LRRELIELLSEMDVVQRGKFILSSGRESDYYVDIKRAVTEPAVLDVIARLIADAAG---- 64
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
E D++AGP LGAVPIATA+SL + KPLL+IRK+KK +GT KLIEG++ GDRV +VEDVT
Sbjct: 65 EVDRIAGPALGAVPIATAVSLYSRKPLLMIRKEKKGYGTSKLIEGDLQKGDRVAVVEDVT 124
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSD 172
TTGGS+++A + ++E+G V FV+VDREEGA + ++EG L PL+ VSD
Sbjct: 125 TTGGSLLKAVRAIQENGGIVEKAFVIVDREEGAVDEFKREGITLIPLLSVSD 176
>gi|11499330 orotate phosphoribosyl transferase (pyrE) [Archaeoglobus fulgidus]
>gi|3914508|sp|O28533|PYRE_ARCFU OROTATE
PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|7450995|pir||D69467 probable orotate
phosphoribosyltransferase (EC 2.4.2.10) AF1741
[similarity] - Archaeoglobus fulgidus
>gi|2648805|gb|AAB89504.1| (AE000982) orotate
phosphoribosyl transferase (pyrE) [Archaeoglobus
fulgidus]
Length = 178
Score = 138 bits (343), Expect = 5e-32
Identities = 77/176 (43%), Positives = 112/176 (62%), Gaps = 10/176 (5%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
+ + LVK +I+ G +KFG F+L+SGK S Y+D+K T P L++I++ + + + L
Sbjct: 4 LADALVKRMIEVGALKFGDFVLSSGKRSRVYVDVKLASTFPDILEMISEGMAAKLKDL-- 61
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
E+D++A ELG VPIA ALSL+ KPL+I RK+KK++G GE+ G++V++VEDV
Sbjct: 62 EFDRIACVELGGVPIAVALSLKMKKPLVIFRKEKKDYGIKGDRIGEVKEGEKVVVVEDVI 121
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEA 176
TTG S + AA+ ++E GA V I VVDREE R L+ +SDL EA
Sbjct: 122 TTGSSALSAARRVEESGASVAAIIAVVDREESGR--------NFMSLLKLSDLIEA 169
>emb|CAC11204.1| (AL445063) orotate phosphoribosyltransferase [Thermoplasma
acidophilum]
Length = 171
Score = 137 bits (341), Expect = 9e-32
Identities = 71/173 (41%), Positives = 109/173 (62%), Gaps = 10/173 (5%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
++E+L+++ G IKFG F+LTSGK S YY+DIK T+P L+ IA R
Sbjct: 4 LEEDLLRV----GAIKFGDFVLTSGKRSTYYVDIKEAATDPSVLRKIASEFSGMIRS--- 56
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
K+AG ELGAVP+ A +L+ P +I+RK++ HGT L+ G+ G+ + ++EDV
Sbjct: 57 --SKIAGMELGAVPLIVATALQMSIPYIIVRKERS-HGTMSLLVGKFEKGEEIDVIEDVV 113
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
TTG SV++A L+E+GA V + VVDREEG + +++ G L+P++ +S +
Sbjct: 114 TTGNSVLKAVNTLRENGAVVKRAYCVVDREEGGSDLLKENGIDLHPIIRISQV 166
>pir||T30520 probable orotate phosphoribosyltransferase (EC 2.4.2.10)
[similarity] - Trypanosoma cruzi
>gi|4210455|dbj|BAA74523.1| (AB017765) OMPDCase-OPRTase
[Trypanosoma cruzi] >gi|4995976|dbj|BAA31359.2|
(AB010285) OMPDCase-OPRTase [Trypanosoma cruzi]
Length = 458
Score = 136 bits (340), Expect = 1e-31
Identities = 67/170 (39%), Positives = 112/170 (65%), Gaps = 2/170 (1%)
Query: 4 ELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYD 63
+L ++ S C++FG+F L SGK S Y+D++ L+T+P L+++A+ R L ++D
Sbjct: 262 DLAAALVASRCVRFGNFTLKSGKNSPIYLDLRRLVTHPSILRVVAREYANVLRTL--QFD 319
Query: 64 KVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTG 123
++ G A+PIATA+SLE + PL+ R++ K +GT IEG+ GDRV++++D+ TTG
Sbjct: 320 RLVGLPYAALPIATAISLEMNIPLVYPRREAKSYGTKAAIEGDYKKGDRVVVIDDIVTTG 379
Query: 124 GSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
G+ + A + LK G E+V I V++DRE GA++ + G++L +V +S L
Sbjct: 380 GTKLEAIEKLKAAGLEIVSIVVLIDREMGAKKFLGSLGYELEAVVTLSQL 429
>sp|P31754|PYR5_BOVIN URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES: OROTATE
PHOSPHORIBOSYLTRANSFERASE (OPRTASE); OROTIDINE
5'-PHOSPHATE DECARBOXYLASE (OMPDECASE)]
>gi|423297|pir||JN0558 UMP synthase - bovine
>gi|832|emb|CAA46253.1| (X65125) uridine 5-monophosphate
synthase [Bos taurus]
Length = 480
Score = 135 bits (337), Expect = 3e-31
Identities = 65/167 (38%), Positives = 107/167 (63%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDK 64
LV + D KFG+F+L SG S YID++ +I+ P L +A+M+ + + I +D
Sbjct: 11 LVTGLYDVQAFKFGNFVLKSGLSSPVYIDLRGIISRPSILNQVAEMLFQTAENAEINFDT 70
Query: 65 VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGG 124
V G A+P+AT + + P+LI RK+KK++GT +LIEG ++PGD L++EDV ++G
Sbjct: 71 VCGVPYTALPLATIVCSTHEIPMLIRRKEKKDYGTKRLIEGAVNPGDTCLIIEDVVSSGS 130
Query: 125 SVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVS 171
SV A++L++ G +V V+VDRE+G R+N++ G +L+ + +S
Sbjct: 131 SVWETAEVLQKEGLKVTDAVVLVDREQGGRDNLQARGIRLHSVCTLS 177
>dbj|BAA19920.1| (D86227) UMP synthase [Homo sapiens]
Length = 480
Score = 133 bits (331), Expect = 1e-30
Identities = 60/171 (35%), Positives = 107/171 (62%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDK 64
LV + D KFG F+L SG S YID++ +++ P+ L +A ++ + ++ GI +D
Sbjct: 11 LVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDT 70
Query: 65 VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGG 124
V G A+P+AT + P+LI RK+ K++GT +L+EG I+PG+ L++EDV T+G
Sbjct: 71 VCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGS 130
Query: 125 SVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
SV+ ++L++ G +V V++DRE+G ++ ++ G +L+ + +S + E
Sbjct: 131 SVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLE 181
>gi|4507835 uridine monophosphate synthetase (orotate phosphoribosyl
transferase and orotidine-5'-decarboxylase) [Homo
sapiens] >gi|131708|sp|P11172|PYR5_HUMAN URIDINE
5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES:
OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRTASE); OROTIDINE
5'-PHOSPHATE DECARBOXYLASE (OMPDECASE)]
>gi|88975|pir||A30148 UMP synthase - human
>gi|340168|gb|AAA61255.1| (J03626) UMP synthase [Homo
sapiens]
Length = 480
Score = 133 bits (331), Expect = 1e-30
Identities = 60/171 (35%), Positives = 107/171 (62%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDK 64
LV + D KFG F+L SG S YID++ +++ P+ L +A ++ + ++ GI +D
Sbjct: 11 LVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDT 70
Query: 65 VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGG 124
V G A+P+AT + P+LI RK+ K++GT +L+EG I+PG+ L++EDV T+G
Sbjct: 71 VCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGS 130
Query: 125 SVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
SV+ ++L++ G +V V++DRE+G ++ ++ G +L+ + +S + E
Sbjct: 131 SVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLE 181
>pir||B70464 probable orotate phosphoribosyltransferase (EC 2.4.2.10)
[similarity] - Aquifex aeolicus
>gi|2984169|gb|AAC07702.1| (AE000762) uridine
5-monophosphate synthase [Aquifex aeolicus]
Length = 183
Score = 133 bits (331), Expect = 1e-30
Identities = 74/159 (46%), Positives = 102/159 (63%), Gaps = 7/159 (4%)
Query: 20 FILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATAL 79
F L+SGK S YY+D+K + +P+ LI K + E ++ D G LGA PIA A+
Sbjct: 26 FKLSSGKLSRYYVDLKQITFDPEGDYLIGKAMYELVKEFNP--DACGGLTLGADPIAYAI 83
Query: 80 ---SLETDKPL--LIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILK 134
SL P+ ++RK+ K HG + IEG ++PG+RV ++EDV TTG S ++A K +
Sbjct: 84 AFVSLMDSNPIKPFVVRKEPKGHGMKRQIEGLLNPGERVAVLEDVVTTGSSALKAVKACR 143
Query: 135 EHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
E+G EV+G+F VVDREEG RENIEKEG LY L +S+L
Sbjct: 144 EYGLEVIGVFAVVDREEGGRENIEKEGIPLYSLFKLSEL 182
>gi|11433324 uridine monophosphate synthetase (orotate phosphoribosyl
transferase and orotidine-5'-decarboxylase) [Homo
sapiens]
Length = 515
Score = 133 bits (331), Expect = 1e-30
Identities = 60/171 (35%), Positives = 107/171 (62%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDK 64
LV + D KFG F+L SG S YID++ +++ P+ L +A ++ + ++ GI +D
Sbjct: 46 LVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDT 105
Query: 65 VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGG 124
V G A+P+AT + P+LI RK+ K++GT +L+EG I+PG+ L++EDV T+G
Sbjct: 106 VCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGS 165
Query: 125 SVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
SV+ ++L++ G +V V++DRE+G ++ ++ G +L+ + +S + E
Sbjct: 166 SVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLE 216
>dbj|BAA19921.1| (D86228) UMP synthase [Homo sapiens]
Length = 480
Score = 132 bits (330), Expect = 2e-30
Identities = 60/171 (35%), Positives = 107/171 (62%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDK 64
LV + D KFG F+L SG S YID++ +++ P+ L +A ++ + ++ GI +D
Sbjct: 11 LVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDT 70
Query: 65 VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGG 124
V G A+P+AT + P+LI RK+ K++GT +L+EG I+PG+ L++EDV T+G
Sbjct: 71 VCGVPYTALPLATVICSTNQIPMLIGRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGS 130
Query: 125 SVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
SV+ ++L++ G +V V++DRE+G ++ ++ G +L+ + +S + E
Sbjct: 131 SVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLE 181
>dbj|BAA94297.1| (AB029444) Orotidine 5'phosphate decarboxylase-Orotate
phosphoribosyltransferase [Leishmania mexicana
amazonensis]
Length = 457
Score = 132 bits (328), Expect = 3e-30
Identities = 67/170 (39%), Positives = 109/170 (63%), Gaps = 2/170 (1%)
Query: 4 ELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYD 63
EL K ++DS C++FG+F L SGK S YID++ L+T P ++L+A+ + R ++D
Sbjct: 260 ELAKALVDSHCVRFGNFTLKSGKSSPIYIDLRRLVTYPAIMRLVAREYAKVLRHY--KFD 317
Query: 64 KVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTG 123
++AG A+PIA+A+S E + PL+ R++ K +GT IEGE GDRV++++D+ +TG
Sbjct: 318 RIAGLPYAALPIASAISNEMNVPLIYPRREAKVYGTKAAIEGEYKKGDRVVIIDDLVSTG 377
Query: 124 GSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
+ + A + L+ G EVV I V+VDR+ GA+ + K G+ +V + L
Sbjct: 378 ETKVEAIEKLRSAGLEVVSIVVLVDRDMGAKAFLNKLGYDFEAVVALHQL 427
>gb|AAA61256.1| (M36661) orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23)
[Homo sapiens]
Length = 468
Score = 132 bits (328), Expect = 3e-30
Identities = 58/167 (34%), Positives = 105/167 (62%)
Query: 9 IIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGP 68
+ D KFG F+L SG S YID++ +++ P+ L +A ++ + ++ GI +D V G
Sbjct: 3 LYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGV 62
Query: 69 ELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIR 128
A+P+AT + P+LI RK+ K++GT +L+EG I+PG+ L++EDV T+G SV+
Sbjct: 63 PYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLE 122
Query: 129 AAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
++L++ G +V V++DRE+G ++ ++ G +L+ + +S + E
Sbjct: 123 TVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLE 169
>dbj|BAA19923.1| (D86230) UMP synthase [Homo sapiens]
Length = 480
Score = 130 bits (324), Expect = 9e-30
Identities = 60/171 (35%), Positives = 106/171 (61%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDK 64
LV + D KFG F+L SG S YID++ +++ P+ L +A ++ + ++ GI +D
Sbjct: 11 LVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDT 70
Query: 65 VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGG 124
V G A+P+AT + P+LI RK+ K++GT +L EG I+PG+ L++EDV T+G
Sbjct: 71 VCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLGEGTINPGETCLIIEDVVTSGS 130
Query: 125 SVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
SV+ ++L++ G +V V++DRE+G ++ ++ G +L+ + +S + E
Sbjct: 131 SVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLE 181
>sp|O08359|PYRE_SULAC OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|2065444|emb|CAA73352.1| (Y12822) orotate
phosphoribosyltransferase [Sulfolobus acidocaldarius]
Length = 197
Score = 124 bits (309), Expect = 5e-28
Identities = 62/173 (35%), Positives = 107/173 (61%), Gaps = 3/173 (1%)
Query: 4 ELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYD 63
+ VK ++D + G+F+LTSGK S YY+D++ L +P + + + GI +D
Sbjct: 2 DFVKALLDKKLLLIGNFMLTSGKVSPYYLDLRKLPNHPDIFSFVVSSAVDIVK--GINFD 59
Query: 64 KVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTG 123
+ G G VP A+ ++ + +KP+ IR +KK HGT +L+E ++ G +V++V+DV TTG
Sbjct: 60 MILGVVTGGVPFASFIACKLNKPMGYIRAEKKGHGTERLLEADVD-GKKVIVVDDVATTG 118
Query: 124 GSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEA 176
GS+++A + +++ G +V V+VDREEGA E +E G +L + VS++ +
Sbjct: 119 GSILKAVEEVRKAGGKVEHALVIVDREEGAFEKLESVGIRLLSVYKVSEILNS 171
>gb|AAF86340.1|AF277455_1 (AF277455) UMP synthase [Nicotiana plumbaginifolia]
Length = 477
Score = 123 bits (307), Expect = 9e-28
Identities = 65/171 (38%), Positives = 102/171 (59%), Gaps = 1/171 (0%)
Query: 3 EELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEY 62
E ++ + D +KFG F L SG S YID++ +++ P L+ I++ + S +Y
Sbjct: 7 ESIILQLHDISAVKFGEFKLKSGISSPIYIDLRLIVSYPSILRQISQTLVG-SLPSSTKY 65
Query: 63 DKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTT 122
D V G A+PIAT +S D P+L+ RK+ K++GT K IEG SPG L+VED+ T+
Sbjct: 66 DVVCGVPYTALPIATCISTAHDVPMLMRRKEVKDYGTAKAIEGAFSPGQACLIVEDLVTS 125
Query: 123 GGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
G SV+ A L+ G V V++DRE+G REN+ + G L+ +V ++++
Sbjct: 126 GASVLETAAPLRAAGLTVTDAVVMIDREQGGRENLAENGITLHSMVKLTEM 176
>sp|P09556|PYR5_DICDI URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES: OROTATE
PHOSPHORIBOSYLTRANSFERASE (OPRTASE); OROTIDINE
5'-PHOSPHATE DECARBOXYLASE (OMPDECASE)]
>gi|84132|pir||S03826 UMP synthase - slime mold
(Dictyostelium discoideum) >gi|7333|emb|CAA30443.1|
(X07560) ORF (AA 1-475) [Dictyostelium discoideum]
Length = 478
Score = 120 bits (299), Expect = 8e-27
Identities = 65/174 (37%), Positives = 107/174 (61%), Gaps = 3/174 (1%)
Query: 3 EELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEY 62
+ELV ++ IK G F L SG S YID++ +++P L IA+M+ ++ K G
Sbjct: 4 KELVLKLMKLMAIKLGEFKLKSGIISPIYIDLRVTVSSPPLLAAIAEMMYQKVYKSGNAQ 63
Query: 63 DK---VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDV 119
+ V G A+PIAT +S+ + P+++ RK+ K +GT +LIEG GD VL+VED+
Sbjct: 64 ETPALVCGVPYTALPIATGMSIANNIPMVVRRKEAKAYGTKQLIEGRFKEGDNVLVVEDL 123
Query: 120 TTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
T+G SV+ + L G +V + V++DR+EGAR+ +EK+G++L+ + + +L
Sbjct: 124 VTSGASVLETVRDLNSVGLKVTDVVVLLDRQEGARQALEKQGYRLHSVFTMEEL 177
>pir||S41014 UMP synthase - Caenorhabditis elegans >gi|3874822|emb|CAA84708.1|
(Z35641) contains similarity to Pfam domain: PF00156
(Phosphoribosyl transferase domain), Score=108.1,
E-value=5.5e-29, N=1; PF00215 (Orotidine 5-phosphate
decarboxylases), Score=208.7, E-value=5.1e-60, N=1~cDNA
EST EMBL:M89423 comes from this gene~cDN>
>gi|3879517|emb|CAA82579.1| (Z29443) contains similarity
to Pfam domain: PF00156 (Phosphoribosyl transferase
domain), Score=108.1, E-value=5.5e-29, N=1; PF00215
(Orotidine 5-phosphate decarboxylases), Score=208.7,
E-value=5.1e-60, N=1~cDNA EST EMBL:M89423 comes from
this gene~cDN>
Length = 497
Score = 120 bits (299), Expect = 8e-27
Identities = 63/169 (37%), Positives = 99/169 (58%), Gaps = 1/169 (0%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
+K L++ ++ + KFG F L SG+ S YID++ +P L LI++ I ++ +
Sbjct: 13 LKRNLLRQMLKASVFKFGEFQLKSGQISPIYIDLRECFGHPGLLMLISEAISKQVEISEV 72
Query: 61 EYDKVAGPELGAVPIAT-ALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDV 119
+Y V G A+P A+ A KPLLI+RK+ K +GT KLIEG P DR++L+EDV
Sbjct: 73 QYAGVLGIPYAALPYASVAAGNYLKKPLLIVRKEAKSYGTKKLIEGLYQPNDRLILIEDV 132
Query: 120 TTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLV 168
TTGGS++ K+L +F ++DRE+G R+ ++ G L+ L+
Sbjct: 133 VTTGGSILDVVKVLHTENLVASDVFCILDREQGGRQKLQDAGVTLHSLL 181
>sp|Q42942|PYR5_TOBAC URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES: OROTATE
PHOSPHORIBOSYLTRANSFERASE (OPRTASE); OROTIDINE
5'-PHOSPHATE DECARBOXYLASE (OMPDECASE)]
>gi|7433947|pir||T02058 UMP synthase - common tobacco
(fragment) >gi|747980|gb|AAC49115.1| (U22260) UMP
synthase [Nicotiana tabacum]
Length = 461
Score = 120 bits (298), Expect = 1e-26
Identities = 63/163 (38%), Positives = 97/163 (58%), Gaps = 1/163 (0%)
Query: 11 DSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPEL 70
D +KFG F L SG S YID++ +++ P L+ I++ + S +YD V G
Sbjct: 1 DISAVKFGEFKLKSGISSPIYIDLRLIVSYPSILRQISQTLVG-SLPSSTKYDVVCGVPY 59
Query: 71 GAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAA 130
A+PIAT +S D P+L+ RK+ K++GT K IEG PG L+VED+ T+G SV+ A
Sbjct: 60 TALPIATCISTAHDVPMLMRRKEVKDYGTAKAIEGAFKPGQACLIVEDLVTSGASVLETA 119
Query: 131 KILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
L+ G V V++DRE+G REN+ + G L+ +V ++++
Sbjct: 120 APLRAAGLTVTDAVVMIDREQGGRENLAENGITLHSMVKLTEM 162
>gb|AAG20258.1| (AE005101) orotate phosphoribosyl transferase; PyrE2 [Halobacterium
sp. NRC-1]
Length = 175
Score = 120 bits (298), Expect = 1e-26
Identities = 67/174 (38%), Positives = 98/174 (55%), Gaps = 4/174 (2%)
Query: 3 EELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEY 62
++LV + + ++FG F L+ G S YY+D T+P+ L IA + E
Sbjct: 5 DDLVSALRAADAVQFGEFELSHGGTSEYYVDKYLFETDPECLSAIAAAFADRID----ED 60
Query: 63 DKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTT 122
+AG LG VP+A A + E P +I RK+ KE+GT IEG + G+ V++VED+ TT
Sbjct: 61 TTLAGVALGGVPLAAATATEAGVPYVIARKQAKEYGTANRIEGRLDDGEEVVVVEDIATT 120
Query: 123 GGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEA 176
G S + A L++ GA V +VVDREEG RE + + G ++ LV SDL +A
Sbjct: 121 GQSAVDAVDALRDAGATVNRALIVVDREEGGRELLAEHGVEMAALVTASDLLDA 174
>gb|AAF86339.1|AF277454_1 (AF277454) UMP synthase [Zea mays]
Length = 478
Score = 120 bits (297), Expect = 1e-26
Identities = 66/172 (38%), Positives = 100/172 (57%), Gaps = 5/172 (2%)
Query: 5 LVKLIIDSGCI---KFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
L LI+D I K G F+L SG S Y+D+++L+ +P+ L ++ ++ +
Sbjct: 8 LESLILDLHAIEAVKLGSFVLKSGITSPIYLDLRALVFHPRLLSAVSSLL--HALPATRP 65
Query: 62 YDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTT 121
Y V G A+PIA LS++ P+L+ RK+ K HGT K IEG PGD VL++ED+ T
Sbjct: 66 YGLVCGVPYTALPIAAVLSVDRSVPMLMRRKEAKAHGTAKSIEGSFRPGDTVLIIEDLVT 125
Query: 122 TGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
+G SV+ A L+ G V VVVDRE+G REN+ G L+ L+ ++++
Sbjct: 126 SGASVLETAAPLRAEGLLVADAVVVVDREQGGRENLAANGITLHSLMTLTEV 177
>dbj|BAA92171.1| (AB031395) UMP synthase 1 [Oryza sativa]
>gi|7381460|gb|AAF61490.1|AF210323_1 (AF210323) UMP
synthase [Oryza sativa]
>gi|7381462|gb|AAF61491.1|AF210324_1 (AF210324) UMP
synthase [Oryza sativa]
Length = 477
Score = 119 bits (295), Expect = 2e-26
Identities = 64/172 (37%), Positives = 102/172 (59%), Gaps = 2/172 (1%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+E L+ + IKFG F+L SG S Y+D+++L+++P L IA ++ +
Sbjct: 6 QESLILELHAIEAIKFGTFVLKSGITSPIYLDLRALVSHPGLLSSIATLL--HTLPATRP 63
Query: 62 YDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTT 121
YD + G A+PIA+ LS+ P+++ RK+ K HGT K IEG G+ VL++ED+ T
Sbjct: 64 YDLLCGVPYTALPIASVLSVHRSVPMVMRRKEAKAHGTAKSIEGAFRAGEAVLIIEDLVT 123
Query: 122 TGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
+G SV+ A L++ G V VVVDRE+G REN+ G L+ L+ ++++
Sbjct: 124 SGASVLETAAPLRDQGLVVADAVVVVDREQGGRENLAANGITLHSLMTLTEV 175
>sp|Q42586|PYR5_ARATH URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES: OROTATE
PHOSPHORIBOSYLTRANSFERASE (OPRTASE); OROTIDINE
5'-PHOSPHATE DECARBOXYLASE (OMPDECASE)]
>gi|1076363|pir||S46440 bifunctional UMP synthase
[validated] - Arabidopsis thaliana
>gi|443818|emb|CAA50686.1| (X71842) pyrE-F [Arabidopsis
thaliana]
Length = 476
Score = 113 bits (281), Expect = 1e-24
Identities = 60/171 (35%), Positives = 102/171 (59%), Gaps = 1/171 (0%)
Query: 3 EELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEY 62
E L+ + + G +KFG+F L SG S YID++ +++ P L I++ + S +
Sbjct: 5 EALILQLHEIGAVKFGNFKLKSGIFSPVYIDLRLIVSYPSLLTQISQTLIS-SLPPSATF 63
Query: 63 DKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTT 122
D V G A+PIAT +S+ P+L+ RK+ K++GT K IEG L++ED+ T+
Sbjct: 64 DVVCGVPYTALPIATVVSVSNGIPMLMRRKEIKDYGTSKAIEGIFEKDQTCLIIEDLVTS 123
Query: 123 GGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
G SV+ A L+ G +V V++DR++G REN+ + G KL+ +++++D+
Sbjct: 124 GASVLETAAPLRAVGLKVSDAVVLIDRQQGGRENLAENGIKLHSMIMLTDM 174
>pir||A70834 probable orotate phosphoribosyltransferase (EC 2.4.2.10) Rv0382c
[similarity] - Mycobacterium tuberculosis (strain H37RV)
>gi|2909503|emb|CAA17388.1| (AL021931) umpA
[Mycobacterium tuberculosis]
Length = 179
Score = 113 bits (281), Expect = 1e-24
Identities = 62/158 (39%), Positives = 96/158 (60%), Gaps = 4/158 (2%)
Query: 18 GHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIAT 77
G L+SG+E++YY+D++ + +A LI ++++E + +Y V G LGA P+AT
Sbjct: 21 GRVTLSSGREADYYVDLRRATLHHRASALIGRLMRELTADW--DYSVVGGLTLGADPVAT 78
Query: 78 ALSLETDKPL--LIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKE 135
A+ +P+ ++RK K HG +LIEG G RVL+VED +TTG S + A +++
Sbjct: 79 AIMHAPGRPIDAFVVRKSAKAHGMQRLIEGSEVTGQRVLVVEDTSTTGNSALTAVHAVQD 138
Query: 136 HGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
G EVVG+ VVDR GA E IE EG + ++ ++DL
Sbjct: 139 VGGEVVGVATVVDRATGAAEAIEAEGLRYRSVLGLADL 176
>pir||T47606 UMP synthase - Arabidopsis thaliana >gi|7258350|emb|CAB77567.1|
(AL138656) UMP synthase [Arabidopsis thaliana]
Length = 476
Score = 113 bits (281), Expect = 1e-24
Identities = 60/171 (35%), Positives = 102/171 (59%), Gaps = 1/171 (0%)
Query: 3 EELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEY 62
E L+ + + G +KFG+F L SG S YID++ +++ P L I++ + S +
Sbjct: 5 EALILQLHEIGAVKFGNFKLKSGIFSPVYIDLRLIVSYPSLLTQISQTLIS-SLPPSATF 63
Query: 63 DKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTT 122
D V G A+PIAT +S+ P+L+ RK+ K++GT K IEG L++ED+ T+
Sbjct: 64 DVVCGVPYTALPIATVVSVSNGIPMLMRRKEIKDYGTSKAIEGIFEKDQTCLIIEDLVTS 123
Query: 123 GGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
G SV+ A L+ G +V V++DR++G REN+ + G KL+ +++++D+
Sbjct: 124 GASVLETAAPLRAVGLKVSDAVVLIDRQQGGRENLAENGIKLHSMIMLTDM 174
>gb|AAK40926.1| Orotate phosphoribosyltransferase (OPRT) (pyrE) [Sulfolobus
solfataricus]
Length = 195
Score = 109 bits (271), Expect = 2e-23
Identities = 58/169 (34%), Positives = 101/169 (59%), Gaps = 4/169 (2%)
Query: 7 KLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVA 66
+++++ + G F+LTSGK S YY+D++ L P+ ++ + IK+ I +D +
Sbjct: 5 EVLLERKLLLIGSFVLTSGKVSPYYLDLRPLPNYPEFYDIVNQAIKKAK---DIPHDIIV 61
Query: 67 GPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSV 126
G G VP++ ++ +P+ IR +KK HGT + +E ++ G RVLLV+DV TTG S+
Sbjct: 62 GIATGGVPLSAFIACNLKEPMGYIRIEKKGHGTNRTLELDVK-GKRVLLVDDVATTGVSI 120
Query: 127 IRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
+A + G +V V++DR+EGA + +EK G KL+ L +S++ +
Sbjct: 121 EKATLEILNGGGKVSDALVIIDRQEGASQRLEKLGVKLHSLFKISEILD 169
>emb|CAB57685.1| (Y18930) orotate phosphoribosyltransferase (OPRT) [Sulfolobus
solfataricus]
Length = 195
Score = 109 bits (271), Expect = 2e-23
Identities = 58/169 (34%), Positives = 101/169 (59%), Gaps = 4/169 (2%)
Query: 7 KLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVA 66
+++++ + G F+LTSGK S YY+D++ L P+ ++ + IK+ I +D +
Sbjct: 5 EVLLERKLLLIGSFVLTSGKVSPYYLDLRPLPNYPEFYDIVNQAIKKAK---DIPHDIIV 61
Query: 67 GPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSV 126
G G VP++ ++ +P+ IR +KK HGT + +E ++ G RVLLV+DV TTG S+
Sbjct: 62 GIATGGVPLSAFIACNLKEPMGYIRIEKKGHGTNRTLELDVK-GKRVLLVDDVATTGVSI 120
Query: 127 IRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
+A + G +V V++DR+EGA + +EK G KL+ L +S++ +
Sbjct: 121 EKATLEILNGGGKVSDALVIIDRQEGASQRLEKLGVKLHSLFKISEILD 169
>gb|AAF55842.1| (AE003733) r-l gene product [Drosophila melanogaster]
Length = 493
Score = 109 bits (270), Expect = 2e-23
Identities = 58/177 (32%), Positives = 98/177 (54%), Gaps = 4/177 (2%)
Query: 9 IIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGP 68
+ + KFG F + G S Y D++ +++ P ++ ++ ++ E + + V G
Sbjct: 16 LFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAKHVCGV 75
Query: 69 ELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIR 128
A+P+AT +S++ P+L+ RK+ K +GT KL+EG + GD L+VEDV T+G S++
Sbjct: 76 PYTALPLATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILD 135
Query: 129 AAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPL----VLVSDLFEAAGVSK 181
+ L+ G V VVVDRE+G NI K G +++ L L++ L EA + K
Sbjct: 136 TVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEK 192
>pir||JU0141 UMP synthase - fruit fly (Drosophila melanogaster)
Length = 493
Score = 107 bits (265), Expect = 8e-23
Identities = 58/177 (32%), Positives = 97/177 (54%), Gaps = 4/177 (2%)
Query: 9 IIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGP 68
+ + KFG F + G S Y D++ +++ P ++ ++ ++ E + + V G
Sbjct: 16 LFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAKHVCGV 75
Query: 69 ELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIR 128
A+P AT +S++ P+L+ RK+ K +GT KL+EG + GD L+VEDV T+G S++
Sbjct: 76 PYTALPRATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILD 135
Query: 129 AAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPL----VLVSDLFEAAGVSK 181
+ L+ G V VVVDRE+G NI K G +++ L L++ L EA + K
Sbjct: 136 TVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEK 192
>pir||T33094 probable orotate phosphoribosyltransferase (EC 2.4.2.10) R12E2.11
[similarity] - Caenorhabditis elegans
>gi|3150523|gb|AAC17032.1| (AF067219) contains
similarity to purine/pyrimidine phosphoribosyl
transferase (Pfam; Pribosyltran, score; 67.36)
[Caenorhabditis elegans]
Length = 227
Score = 105 bits (260), Expect = 3e-22
Identities = 52/162 (32%), Positives = 94/162 (57%)
Query: 14 CIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAV 73
C + G F L SG+ + YID++ ++++P+ L++ A+ + E+ +++D V G A+
Sbjct: 42 CFRTGEFYLKSGQMTPIYIDLRRIMSSPRVLRMAAQAMCEKIVASNLKFDYVVGVPYAAL 101
Query: 74 PIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKIL 133
P+AT +S + P+L+ RK+ K +GT +LIEG PG VLLVEDV T+G S+ A+ +
Sbjct: 102 PLATLVSDILNVPMLMKRKEAKAYGTKQLIEGVYQPGGTVLLVEDVVTSGESIRETAEAI 161
Query: 134 KEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFE 175
+ V V+DR++GA N+ ++ + + + +
Sbjct: 162 RNENLLVTDAIAVLDRQQGATANLAEDNLNFLSFLTMEKILD 203
>sp|Q01637|PYR5_DROME URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) (RUDIMENTARY-LIKE
PROTEIN) [INCLUDES: OROTATE PHOSPHORIBOSYLTRANSFERASE
(OPRTASE); OROTIDINE 5'-PHOSPHATE DECARBOXYLASE
(OMPDECASE)] >gi|158794|gb|AAA29012.1| (L00968) UMP
synthase; r-l gene product [Drosophila melanogaster]
Length = 493
Score = 101 bits (249), Expect = 6e-21
Identities = 57/177 (32%), Positives = 95/177 (53%), Gaps = 4/177 (2%)
Query: 9 IIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGP 68
+ + KFG F + G S Y D++ +++ + ++ ++ E + + V G
Sbjct: 16 LFEINAFKFGDFKMKVGINSPVYFDLRVIVSLGLPQQTVSDLLVEHIKDKQLSAKHVCGV 75
Query: 69 ELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIR 128
A+P AT +S++ P+L+ RK+ K +GT KL+EG + GD L+VEDV T+G S++
Sbjct: 76 PYTALPRATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILD 135
Query: 129 AAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPL----VLVSDLFEAAGVSK 181
+ L+ G V VVVDRE+G NI K G +++ L L++ L EA + K
Sbjct: 136 TVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEK 192
>pir||B72463 probable orotate phosphoribosyltransferase (EC 2.4.2.10) APE2349
[similarity] - Aeropyrum pernix (strain K1)
>gi|5106051|dbj|BAA81362.1| (AP000064) 178aa long
hypothetical orotate phosphoribosyltransferase
[Aeropyrum pernix]
Length = 178
Score = 99.8 bits (245), Expect = 2e-20
Identities = 56/174 (32%), Positives = 96/174 (54%), Gaps = 1/174 (0%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDK 64
L K++ G + G F+L+SG+ S+ YID++ L+ + + + ++ E +
Sbjct: 2 LAKVLKKRGAVLRGDFVLSSGRRSSVYIDMRRLLGDESSYSVALDLLLEVGGQDLARSSA 61
Query: 65 VAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGG 124
V G G +P A L+L KPL +R ++K HGT +EG+ P RV++V+DV TTG
Sbjct: 62 VIGVATGGLPWAAMLALRLSKPLGYVRPERKGHGTLSQVEGD-PPKGRVVVVDDVATTGT 120
Query: 125 SVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEAAG 178
S+ ++ ++L+ +G V V+VDR EGA E + + G +L + + + E G
Sbjct: 121 SIAKSIEVLRSNGYTVGTALVLVDRGEGAGELLARMGVRLVSVATLKTILEKLG 174
>pir||S76099 probable orotate phosphoribosyltransferase (EC 2.4.2.10) slr0185
[similarity] - Synechocystis sp. (strain PCC 6803)
>gi|1001452|dbj|BAA10077.1| (D63999) uridine
5-monophosphate synthase [Synechocystis sp.]
Length = 198
Score = 99.5 bits (244), Expect = 2e-20
Identities = 63/164 (38%), Positives = 97/164 (58%), Gaps = 9/164 (5%)
Query: 16 KFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPI 75
K G FIL+SG+ S YYI+ K + + I +++ E L + + VAG LGA PI
Sbjct: 31 KEGDFILSSGQPSTYYINGKLVTLRAEGALAIGRLLLTE---LPDQVEAVAGLTLGADPI 87
Query: 76 ATALSLET---DKPL--LIIRKKKKEHGTGKLIEG-EISPGDRVLLVEDVTTTGGSVIRA 129
+A+S + +KP+ LIIRK+ K HGT IEG E++PG +V+++EDV TTG S + A
Sbjct: 88 VSAVSTVSAYEEKPVVALIIRKEAKGHGTKAYIEGPELAPGTKVVVLEDVVTTGKSAMLA 147
Query: 130 AKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDL 173
+ L+ G +V + +VDR++G RE + +G L + D+
Sbjct: 148 VERLRNAGYQVDTVISLVDRQQGGREFYQSQGLTFQALFTIGDI 191
>pir||T36540 probable orotate phosphoribosyltransferase (EC 2.4.2.10) SCH10.28c
[similarity] - Streptomyces coelicolor
>gi|4753874|emb|CAB42037.1| (AL049754) putative uridine
5'-monophosphate synthase [Streptomyces coelicolor
A3(2)]
Length = 182
Score = 96.0 bits (235), Expect = 3e-19
Identities = 55/163 (33%), Positives = 95/163 (57%), Gaps = 8/163 (4%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
++ EL++ I D + G L+SG E++YY+D++ + + +A L+ +++ + + L
Sbjct: 4 VRGELLQQIKDKAVVH-GKVTLSSGLEADYYVDLRRITLDGEAAPLVGQVLLDLTADL-- 60
Query: 61 EYDKVAGPELGAVPIATAL-----SLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
E+D V G +GA P+A ++ + ++RK K HG + +EG G RV++
Sbjct: 61 EFDAVGGLTMGADPVAASMLHAAAARGRRLDAFVVRKTAKAHGLQRRVEGPEIKGRRVVV 120
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIE 158
VED +TTGGS + A + ++E GAEVV + +VDR GA E I+
Sbjct: 121 VEDTSTTGGSPLTAVEAVREAGAEVVAVATIVDRATGAGEKIQ 163
>sp|P08870|PYRE_SALTY OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|479221|pir||S32801 orotate phosphoribosyltransferase
(EC 2.4.2.10) pyrE [validated] - Salmonella typhimurium
>gi|1310916|pdb|1OPR| Mol_id: 1; Molecule: Orotate
Phosphoribosyltransferase; Chain: Null; Synonym:
Oprtase; Ec: 2.4.2.10; Engineered: Yes
>gi|47812|emb|CAA79607.1| (Z19547) orotate
phosphoribosyltransferase [Salmonella typhimurium]
Length = 213
Score = 94.0 bits (230), Expect = 1e-18
Identities = 55/185 (29%), Positives = 99/185 (52%), Gaps = 15/185 (8%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ + ++ ++ +KFG F L SG++S Y+ + L + L L+ + E GIE
Sbjct: 5 QRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNA-GLFNTGRDLALLGRFYAEALVDSGIE 63
Query: 62 YDKVAGPELGAVPIATALSL------ETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP +PIAT ++ + D P RK+ K+HG G + G G RV+L
Sbjct: 64 FDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKEAKDHGEGGSLVGSALQG-RVML 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGAR------ENIEKE-GFKLYPLV 168
V+DV T G ++ + +I++ HGA + G+ + +DR+E R + +E++ G K+ ++
Sbjct: 123 VDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVISII 182
Query: 169 LVSDL 173
+ DL
Sbjct: 183 TLKDL 187
>pdb|1STO| Orotate Phosphoribosyltransferase (Oprtase) (E.C.2.4.2.10)
Length = 213
Score = 93.2 bits (228), Expect = 2e-18
Identities = 55/185 (29%), Positives = 98/185 (52%), Gaps = 15/185 (8%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ + ++ ++ +KFG F L SG++S Y+ + L + L L+ + E GIE
Sbjct: 5 QRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNA-GLFNTGRDLALLGRFYAEALVDSGIE 63
Query: 62 YDKVAGPELGAVPIATALSL------ETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP +PIAT ++ + D P RK K+HG G + G G RV+L
Sbjct: 64 FDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKAAKDHGEGGSLVGSALQG-RVML 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGAR------ENIEKE-GFKLYPLV 168
V+DV T G ++ + +I++ HGA + G+ + +DR+E R + +E++ G K+ ++
Sbjct: 123 VDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVISII 182
Query: 169 LVSDL 173
+ DL
Sbjct: 183 TLKDL 187
>sp|Q25566|PYR5_NAEGR URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES: OROTATE
PHOSPHORIBOSYLTRANSFERASE (OPRTASE); OROTIDINE
5'-PHOSPHATE DECARBOXYLASE (OMPDECASE)]
>gi|159723|gb|AAA29385.1| (L08073) OMP synthase
[Naegleria gruberi]
Length = 494
Score = 91.7 bits (224), Expect = 5e-18
Identities = 56/172 (32%), Positives = 96/172 (55%), Gaps = 9/172 (5%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
+K+ELV +I G +KFG F L SG S +Y+D++ I PK L+ + ++ G+
Sbjct: 11 LKKELVLDLIQIGALKFGRFTLKSGIVSPFYVDLR--IIGPKMLRQFSVLLYHVMTVKGL 68
Query: 61 ---EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGD-RVLLV 116
E + G A+ ++ +S+ D P++I RK++K++GTG ++EG + + +L+
Sbjct: 69 TNMEKRVICGVPYSALTFSSCMSMTYDLPMVICRKERKQYGTGNMVEGIYTKNETNCILI 128
Query: 117 EDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGAREN---IEKEGFKLY 165
EDV T+G S++ A+ L+ G V V + RE+ N I K+G K+Y
Sbjct: 129 EDVITSGASIVETAEKLENEGLLVTDALVFLTREQLPLTNGMHILKKGEKVY 180
>sp|P46534|PYRE_BACCL OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|2117731|pir||I40173 orotate
phosphoribosyltransferase (EC 2.4.2.10) pyrE
[similarity] - Bacillus caldolyticus
>gi|312447|emb|CAA51743.1| (X73308) orotate
phosphoribosyltransferase [Bacillus caldolyticus]
Length = 206
Score = 89.3 bits (218), Expect = 2e-17
Identities = 57/181 (31%), Positives = 91/181 (49%), Gaps = 5/181 (2%)
Query: 1 MKEELVKLIIDSGCIKFGH---FILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRK 57
MK ++ ++ G + F +SG +S Y D + + P +LIA + E R
Sbjct: 1 MKHDIAAKLLQIGAVALQPNEPFTWSSGLKSPIYCDNRLTLAYPGVRRLIADALAELIRT 60
Query: 58 LGIEYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVE 117
+ D +AG G +P A +S + P+ +R + K HG GK IEG+ PG RV+++E
Sbjct: 61 HFPKADLIAGTAAG-IPHAAWVSERLELPMCYVRSQAKRHGKGKQIEGQARPGQRVVVIE 119
Query: 118 DVTTTGGSVIRAAKILKEHGAEVVGIFVVVDRE-EGARENIEKEGFKLYPLVLVSDLFEA 176
D+ +TGG+ + A + LKE G EV+G+ + E A++ E Y L + L E
Sbjct: 120 DLISTGGTSLAAVRALKEAGCEVLGVAAIFTYGLEKAKQAFAAENLPAYTLTDYNTLIET 179
Query: 177 A 177
A
Sbjct: 180 A 180
>sp|P00495|PYRE_ECOLI OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|7427941|pir||XJEC orotate phosphoribosyltransferase
(EC 2.4.2.10) pyrE [similarity] - Escherichia coli
>gi|1421029|pdb|1ORO|A Chain A, A Flexible Loop At The
Dimer Interface Is A Part Of The Active Site Of The
Adjacent Monomer Of Escherichia Coli Orotate
Phosphoribosyltransferase >gi|1421030|pdb|1ORO|B Chain
B, A Flexible Loop At The Dimer Interface Is A Part Of
The Active Site Of The Adjacent Monomer Of Escherichia
Coli Orotate Phosphoribosyltransferase
>gi|643610|gb|AAA61995.1| (L10328) orotate
phosphoribosyltransferase [Escherichia coli]
>gi|755728|emb|CAA25358.1| (X00781) orotate
phosphoribosyltransferase [Escherichia coli]
>gi|1790073|gb|AAC76666.1| (AE000441) orotate
phosphoribosyltransferase [Escherichia coli K12]
Length = 213
Score = 88.2 bits (215), Expect = 6e-17
Identities = 50/162 (30%), Positives = 86/162 (52%), Gaps = 8/162 (4%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ + ++ + +KFG F L SG++S Y+ + L + L L+ + E GIE
Sbjct: 5 QRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNA-GLFNTGRDLALLGRFYAEALVDSGIE 63
Query: 62 YDKVAGPELGAVPIATALSL------ETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP +PIAT ++ + D P RK+ K+HG G + G G RV+L
Sbjct: 64 FDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQG-RVML 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENI 157
V+DV T G ++ + +I++ +GA + G+ + +DR+E R I
Sbjct: 123 VDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEI 164
>emb|CAA05335.1| (AJ002318) orotate phosphoribosyltransferase [Rhizomucor
circinelloides f. lusitanicus]
Length = 218
Score = 86.2 bits (210), Expect = 2e-16
Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 8/168 (4%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ E ++ + + +KFG F L SG+ S Y+ + L + K L I G +
Sbjct: 5 QREFIEFALKNEVLKFGSFHLKSGRTSPYFFNA-GLFNSGKTLGAIGTFYAAALEDAGFD 63
Query: 62 YDKVAGPELGAVPI--ATALSLETD----KPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
YD + GP +P+ ATALSL D P RK+KK+HG G I G G ++++
Sbjct: 64 YDVLFGPAYKGIPLVCATALSLSNDYGKDAPFSFNRKEKKDHGEGGNIVGTPLNG-KIVV 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFK 163
V+DV T G ++ + +I+K++ A++ G+ V VDR E A + K +
Sbjct: 123 VDDVITAGTAINESIEIIKQNNAQLAGVLVAVDRAEIAPDGTGKSAIQ 170
>pir||C75517 orotate phosphoribosyltransferase - Deinococcus radiodurans
(strain R1) >gi|6458131|gb|AAF10026.1|AE001904_2
(AE001904) orotate phosphoribosyltransferase
[Deinococcus radiodurans]
Length = 194
Score = 85.4 bits (208), Expect = 4e-16
Identities = 48/175 (27%), Positives = 96/175 (54%), Gaps = 10/175 (5%)
Query: 4 ELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYD 63
+++ L +G G F+L SG++S Y++ +L+ +P+AL + ++ ++ G++ D
Sbjct: 5 DVLDLYKQAGAFHEGRFLLASGRQSPYFMQSTTLLQHPRALMELGGLMSQKILDAGLKPD 64
Query: 64 KVAGPELGAVPIATALSLETDKPLLIIR---KKKKEHGTGKLIEG-EISPGDRVLLVEDV 119
+ GP +G V +A ++ + + L +R +K G KL E + PG+ + VEDV
Sbjct: 65 FIVGPAMGGVTLAYEVARQLSETLPDVRAIFAEKDGSGGMKLREAFAVRPGETFVAVEDV 124
Query: 120 TTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLF 174
TTGGS++RA + ++ G + +G+ ++DR + + YPL+ + +L+
Sbjct: 125 LTTGGSLLRAVRAVEGQGGQCIGLCCIIDRRQ------QTGPLSGYPLMSLKELY 173
>dbj|BAA98815.1| (AP002547) uridine 5'-monophosphate synthase [Chlamydophila
pneumoniae J138]
Length = 210
Score = 85.4 bits (208), Expect = 4e-16
Identities = 51/178 (28%), Positives = 99/178 (54%), Gaps = 4/178 (2%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
++ + V ++ G IKFG IL SG+E+ Y+D++ +I++P+ L+ +A +I + +
Sbjct: 9 LRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWQ--LRPSF 66
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLI--EGEISPGDRVLLVED 118
+ G A+ +AT++SL+ + P+++ RK+ + I EG +PG L++ D
Sbjct: 67 NSSLLCGVPYTALTLATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVIND 126
Query: 119 VTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEA 176
+ ++G S+I A L+E+G V V +DR + A + + +G K+ + V L +A
Sbjct: 127 MVSSGKSIIETAVALEENGLVVREALVFLDRRKEACQPLGPQGIKVSSVFTVPTLIKA 184
>pir||B72058 probable orotate phosphoribosyltransferase (EC 2.4.2.10) CPn0608
[similarity] - Chlamydophila pneumoniae (strain CWL029)
>gi|4376904|gb|AAD18747.1| (AE001645) Uridine
5'-Monophosphate Synthase [Chlamydophila pneumoniae
CWL029] >gi|8163369|gb|AAF73630.1| (AE002175)
phosphoribosyl transferase family protein [Chlamydophila
pneumoniae AR39]
Length = 210
Score = 84.7 bits (206), Expect = 6e-16
Identities = 51/178 (28%), Positives = 98/178 (54%), Gaps = 4/178 (2%)
Query: 1 MKEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
++ + V ++ G IKFG IL SG+E+ Y+D++ +I++P+ L+ +A +I +
Sbjct: 9 LRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWR--LRPSF 66
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLI--EGEISPGDRVLLVED 118
+ G A+ +AT++SL+ + P+++ RK+ + I EG +PG L++ D
Sbjct: 67 NSSLLCGVPYTALTLATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVIND 126
Query: 119 VTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEGFKLYPLVLVSDLFEA 176
+ ++G S+I A L+E+G V V +DR + A + + +G K+ + V L +A
Sbjct: 127 MVSSGKSIIETAVALEENGLVVREALVFLDRRKEACQPLGPQGIKVSSVFTVPTLIKA 184
>dbj|BAB06251.1| (AP001515) orotate phosphoribosyltransferase [Bacillus halodurans]
Length = 210
Score = 84.3 bits (205), Expect = 8e-16
Identities = 56/181 (30%), Positives = 91/181 (49%), Gaps = 4/181 (2%)
Query: 1 MKEELVKLIIDSGCIKF---GHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRK 57
MKE + + ++D + F +SG +S Y D + + P + IA+ ++ R
Sbjct: 1 MKETIAQHLLDIEAVTLRPNDPFTWSSGIKSPIYCDNRLTMGYPHIRQSIAEGFEQLIRS 60
Query: 58 LGIEYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVE 117
E VAG +P A +S P++ +R K K HG IEG++S DRV+++E
Sbjct: 61 HFPEVTVVAGTATAGIPHAAWVSDRLQAPMVYVRSKSKGHGKQNQIEGKLSSKDRVVIIE 120
Query: 118 DVTTTGGSVIRAAKILKEHGAEVVGIFVVVDRE-EGARENIEKEGFKLYPLVLVSDLFEA 176
D+ +TGGSVI+AA L+E GA+V+G+ + E ++ +E Y L L +
Sbjct: 121 DLISTGGSVIQAADALREAGADVLGVVAIFTYGLEKGQDQLEAANLPSYVLTDYPTLLDV 180
Query: 177 A 177
A
Sbjct: 181 A 181
>pir||E82350 orotate phosphoribosyltransferase VC0211 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9654618|gb|AAF93387.1| (AE004111) orotate
phosphoribosyltransferase [Vibrio cholerae]
Length = 214
Score = 83.5 bits (203), Expect = 1e-15
Identities = 52/185 (28%), Positives = 96/185 (51%), Gaps = 15/185 (8%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ E ++ ++ +KFG F L SG++S Y+ + L + L + + GIE
Sbjct: 6 QREFIEFALEKQVLKFGEFTLKSGRKSPYFFNA-GLFNTGRDLARLGRFYAAALVDSGIE 64
Query: 62 YDKVAGPELGAVPIATALSL------ETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP +PIAT ++ + D P RK+ K HG G + G G RV+L
Sbjct: 65 FDVLFGPAYKGIPIATTTAVALADHHDVDTPYCFNRKEAKNHGEGGNLVGSKLEG-RVML 123
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE------GARENIEKE-GFKLYPLV 168
V+DV T G ++ + ++++ + A++ G+ V +DR+E A + +E++ G + +V
Sbjct: 124 VDDVITAGTAIRESMELIQANKADLAGVLVAIDRQEKGKGELSAIQEVERDFGCAVISIV 183
Query: 169 LVSDL 173
++DL
Sbjct: 184 SLTDL 188
>emb|CAA24899.1| (V01578) orotate phosphoribosyltransferase (pyrE) [Escherichia
coli]
Length = 212
Score = 83.1 bits (202), Expect = 2e-15
Identities = 50/162 (30%), Positives = 85/162 (51%), Gaps = 9/162 (5%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ + ++ + +KFG F L SG++S Y+ + L + L L+ + E GIE
Sbjct: 5 QRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNA-GLFNTGRDLALLGRFYAEALVDSGIE 63
Query: 62 YDKVAGPELGAVPIATALSL------ETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP +PIAT ++ + D P RK+ K+HG G + G G RV+L
Sbjct: 64 FDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQG-RVML 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENI 157
V+DV T G + + +I++ +GA + G+ + +DR+E R I
Sbjct: 123 VDDVITAG-TARESMEIIQANGATLAGVLISLDRQERGRGEI 163
>gb|AAC95453.1| (AF068902) orotate phosphoribosyltransferase PyrE [Streptococcus
pneumoniae]
Length = 210
Score = 83.1 bits (202), Expect = 2e-15
Identities = 48/159 (30%), Positives = 79/159 (49%), Gaps = 1/159 (0%)
Query: 20 FILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATAL 79
F SG +S Y D + + P+ LI + ++ E + +AG +P +
Sbjct: 25 FTWASGIKSPIYTDNRVTLAYPETRTLIENGFVDAIKEAFPEVEVIAGTATAGIPHGAII 84
Query: 80 SLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAE 139
+ + + P IR K K+HG G IEG ++ G ++++VED+ +TGGSV+ A K GA+
Sbjct: 85 ADKMNLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGAD 144
Query: 140 VVGIFVVVDRE-EGARENIEKEGFKLYPLVLVSDLFEAA 177
V+G+ + + A +N G KL L S+L A
Sbjct: 145 VLGVVAIFSYQLPKADKNFADAGVKLVTLSNYSELIHLA 183
>sp|Q9WYG6|PYRE_THEMA OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|7462908|pir||E72390 orotate
phosphoribosyltransferase - Thermotoga maritima (strain
MSB8) >gi|4980832|gb|AAD35418.1|AE001714_9 (AE001714)
orotate phosphoribosyltransferase [Thermotoga maritima]
Length = 187
Score = 82.7 bits (201), Expect = 2e-15
Identities = 55/152 (36%), Positives = 86/152 (56%), Gaps = 11/152 (7%)
Query: 5 LVKLIID-SGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYD 63
++K I++ +G + GHFIL+SGK S+ Y+ L P+ ++ EE KL +YD
Sbjct: 1 MIKEILEKTGALMEGHFILSSGKHSSRYVQCARLFEFPE----YGDVVGEELAKLLKKYD 56
Query: 64 --KVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGE-ISPGDRVLLVEDVT 120
V GP +G V ++ ++ L ++E+G KL G + PG++V +VEDV
Sbjct: 57 VETVVGPAMGGVILSYVVARYLKARSLFA---ERENGVMKLRRGFFVKPGEKVAVVEDVV 113
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDREEG 152
TTGGSV ++LKE+GA VV + ++DR G
Sbjct: 114 TTGGSVKEVIELLKEYGANVVCVGSIIDRSGG 145
>sp|P50587|PYRE_PSEAE OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|1079661|gb|AAC44427.1| (U38241) orotate
phosphoribosyl transferase [Pseudomonas aeruginosa]
Length = 213
Score = 82.3 bits (200), Expect = 3e-15
Identities = 53/187 (28%), Positives = 96/187 (50%), Gaps = 15/187 (8%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ + ++ I+ G ++FG F L SG+ S Y+ + L + AL + + E GI+
Sbjct: 5 QRDFIRFAIERGVLRFGEFTLKSGRTSPYFFNA-GLFDSGLALARLGRFYAEAVIDSGID 63
Query: 62 YDKVAGPELGAVPIA--TALSL----ETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP +P+A TA++L + D P RK+ KEHG G + G G RVL+
Sbjct: 64 FDVLFGPAYKGIPLAATTAVALAEQHQRDLPWCFNRKEAKEHGEGGTLVGAPLSG-RVLI 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE------GARENIEKE-GFKLYPLV 168
++DV T G ++ +I+ GA G+ + ++R+E A + +E++ G + +V
Sbjct: 123 IDDVITAGTAIREVMQIIDAQGARAAGVLIALNRQERGKGELSAIQEVERDFGMPVVSIV 182
Query: 169 LVSDLFE 175
+ + E
Sbjct: 183 SLEQVLE 189
>pir||A82981 orotate phosphoribosyltransferase PA5331 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951649|gb|AAG08716.1|AE004945_10 (AE004945) orotate
phosphoribosyltransferase [Pseudomonas aeruginosa]
Length = 213
Score = 81.1 bits (197), Expect = 7e-15
Identities = 52/187 (27%), Positives = 96/187 (50%), Gaps = 15/187 (8%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+ + ++ I+ G ++FG F L SG+ S Y+ + L + AL + + E GI+
Sbjct: 5 QRDFIRFAIERGVLRFGEFTLKSGRTSPYFFNA-GLFDSGLALARLGRFYAEAVIDSGID 63
Query: 62 YDKVAGPELGAVPIA--TALSL----ETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP +P+A TA++L + D P RK+ K+HG G + G G RVL+
Sbjct: 64 FDVLFGPAYKGIPLAATTAVALAEQHQRDLPWCFNRKEAKDHGEGGTLVGAPLSG-RVLI 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE------GARENIEKE-GFKLYPLV 168
++DV T G ++ +I+ GA G+ + ++R+E A + +E++ G + +V
Sbjct: 123 IDDVITAGTAIREVMQIIDAQGARAAGVLIALNRQERGKGELSAIQEVERDFGMPVVSIV 182
Query: 169 LVSDLFE 175
+ + E
Sbjct: 183 SLEQVLE 189
>pir||A81441 probable orotate phosphoribosyltransferase (EC 2.4.2.10) Cj0233c
[imported] - Campylobacter jejuni (strain NCTC 11168)
>gi|6967711|emb|CAB72702.1| (AL139074) putative orotate
phosphoribosyltransferase [Campylobacter jejuni]
Length = 202
Score = 79.6 bits (193), Expect = 2e-14
Identities = 48/157 (30%), Positives = 82/157 (51%), Gaps = 8/157 (5%)
Query: 5 LVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLG---IE 61
L ++ D G GHF+L+SGK S +Y+ ++ +P KL AK+ E ++ + IE
Sbjct: 3 LEQIYKDCGAYLEGHFLLSSGKHSQFYLQSAKVLEDP---KLAAKLCDELAKIIASYKIE 59
Query: 62 YDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTT 121
+D + P LG + L+ K + + KE + E+ G++ ++ ED+ T
Sbjct: 60 FDSICSPALGGILAGYELARACSKRFIFTERVNKEMTLRRGF--EVKKGEKFIICEDIIT 117
Query: 122 TGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIE 158
TGGS + +AKI++ G VVG + +R A EN++
Sbjct: 118 TGGSALESAKIIESLGGIVVGFAALANRGFCAVENLK 154
>sp|P21846|PYRE_TRIRE OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE) (OPRT)
>gi|102025|pir||S13091 orotate phosphoribosyltransferase
(EC 2.4.2.10) - fungus (Trichoderma reesei)
>gi|5188|emb|CAA39364.1| (X55879) orotate
phosphoribosyltransferase [Hypocrea jecorina]
>gi|236249|gb|AAB19948.1| orotate pyrophosphoribosyl
transferase, ORPTase [Trichoderma reesei, Peptide, 236
aa]
Length = 236
Score = 78.8 bits (191), Expect = 4e-14
Identities = 53/162 (32%), Positives = 80/162 (48%), Gaps = 12/162 (7%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKL---IAKMIKEESRKL 58
K++ +K ID G +KFG F L S + S Y+ + T A ++ AK I E K
Sbjct: 11 KQDFLKSAIDGGVLKFGSFELKSKRISPYFFNAGEFHTARLARRIASAFAKTIIEAQEKA 70
Query: 59 GIEYDKVAGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIEGEISP 109
G+E+D V GP +P+ +A++++ RK+ K+HG G I G
Sbjct: 71 GLEFDIVFGPAYKGIPLCSAITIKLGDVAPQNLDRVSYSFDRKEAKDHGEGGNIVGASLK 130
Query: 110 GDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
G RVL+V+DV T G + A + + + G GI V +DR E
Sbjct: 131 GKRVLIVDDVITAGTAKRDAIEKITKEGRHRRGIVVALDRME 172
>pir||H82840 orotate phosphoribosyl transferase XF0153 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9104944|gb|AAF82966.1|AE003869_3 (AE003869) orotate
phosphoribosyl transferase [Xylella fastidiosa]
Length = 219
Score = 78.4 bits (190), Expect = 5e-14
Identities = 48/159 (30%), Positives = 80/159 (50%), Gaps = 6/159 (3%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
++ ++L +DS + FG F L SG+ S Y+ + + K L A+ + +
Sbjct: 5 RQRFLQLALDSNALCFGEFTLKSGRISPYFFNAGHFNSGAKTAAL-AQCYADAIDAANMN 63
Query: 62 YDKVAGPELGAVPIATALSLE-----TDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLV 116
+D V GP +P+ATAL+ E D L RK+ K HG G + G G ++L++
Sbjct: 64 FDLVFGPAYKGIPLATALACEYARRERDLLLAFNRKEVKNHGEGGTLIGAPLNGRKILII 123
Query: 117 EDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARE 155
+DV T G ++ +I++ G GI V ++R+E A E
Sbjct: 124 DDVITAGTAIREVLRIIRNAGGTPTGIAVALNRQEIASE 162
>pir||H81032 probable orotate phosphoribosyltransferase (EC 2.4.2.10) NMA0582
[imported] - Neisseria meningitidis (group B strain
MD58, group A strain Z2491) >gi|7227132|gb|AAF42208.1|
(AE002537) orotate phosphoribosyltransferase [Neisseria
meningitidis MC58] >gi|7379318|emb|CAB83873.1|
(AL162753) putative orotate phosphoribosyltransferase
[Neisseria meningitidis Z2491]
Length = 213
Score = 78.0 bits (189), Expect = 6e-14
Identities = 50/185 (27%), Positives = 94/185 (50%), Gaps = 14/185 (7%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
+++ +K + +KFG F +G+ S Y+ + L + + +AK + + GI
Sbjct: 5 RQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNA-GLFNDGLSTLQLAKFYAQSIIESGIR 63
Query: 62 YDKVAGPELGAVPIATALSLE-----TDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLV 116
+D + GP + +A A ++ + P RK+ K+HG G ++ G G RVL++
Sbjct: 64 FDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKG-RVLII 122
Query: 117 EDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE------GARENIEKE-GFKLYPLVL 169
+DV + G SV + K+++ GA G+ + +DR E A + +EK+ G + P+
Sbjct: 123 DDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGELSAVQEVEKQYGLPVAPIAS 182
Query: 170 VSDLF 174
++DLF
Sbjct: 183 LNDLF 187
>pir||S44298 probable orotate phosphoribosyltransferase (EC 2.4.2.10)
[similarity] - Coxiella burnetii
>gi|483520|emb|CAA55676.1| (X79075) similarity to
orotate phosphoribosyl transferase from Bacillus
subtilis [Coxiella burnetii]
Length = 209
Score = 77.6 bits (188), Expect = 8e-14
Identities = 51/178 (28%), Positives = 82/178 (45%), Gaps = 4/178 (2%)
Query: 4 ELVKLIIDSGCIKFG---HFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGI 60
E+ KL+++ + + TSG S Y D + +I+ P+ K+I + + K +
Sbjct: 6 EIAKLLLNIKAVTLNLHEPYRYTSGILSPIYCDNRLIISYPEKRKMIIEAFLQLIEKNHL 65
Query: 61 EYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVT 120
+D VAG +P A ++ D P++ +R K K HG IEG I G R L+VED+
Sbjct: 66 SFDIVAGTATAGIPHAAWIADRLDLPMIYVRAKAKTHGKQNQIEGRIRKGQRALIVEDLI 125
Query: 121 TTGGSVIRAAKILKEHGAEVVGIFVVVDRE-EGARENIEKEGFKLYPLVLVSDLFEAA 177
+TG S + A L+E G V + + A++N + L L E A
Sbjct: 126 STGKSALAAGLALREKGVTVTDCIAIFSYQLPQAQQNFSDANINCHALSHFDTLIEMA 183
>sp|O42767|PYRE_METAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE) (OPRT)
>gi|2853621|gb|AAC02431.1| (AF038545) orotate
phosphoribosyl transferase [Metarhizium anisopliae]
Length = 234
Score = 77.3 bits (187), Expect = 1e-13
Identities = 48/162 (29%), Positives = 82/162 (49%), Gaps = 12/162 (7%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKL---IAKMIKEESRKL 58
K+E +K I+ G +KFG F L S + S Y+ + T A + AK I + +
Sbjct: 9 KQEFLKAAIEGGVLKFGSFELKSKRISPYFFNAGEFHTAHLAGAISSAFAKTIIDAQQNA 68
Query: 59 GIEYDKVAGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIEGEISP 109
G+++D + GP +P+ +A++++ + RK+ K+HG G I G
Sbjct: 69 GLDFDIIFGPAYKGIPLCSAITIKLGEISPQNLDTVSYSFDRKEAKDHGEGGNIVGASLK 128
Query: 110 GDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
G ++L+V+DV T G + A +++ G V GI V +DR+E
Sbjct: 129 GKKILIVDDVITAGTAKREAIDKIRKEGGIVAGIVVALDRKE 170
>sp|P41923|PYRE_YARLI OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE) (OPRT)
>gi|630379|pir||S44156 orotate phosphoribosyltransferase
(EC 2.4.2.10) - yeast (Yarrowia lipolytica)
>gi|1362498|pir||S55840 orotate
phosphoribosyltransferase (EC 2.4.2.10) URA5 [validated]
- yeast (Yarrowia lipolytica) >gi|473181|emb|CAA80294.1|
(Z22571) orotate phosphoribosyl transferase [Yarrowia
lipolytica] >gi|5834779|emb|CAB55334.1| (AJ006754)
orotate phosphoribosyltransferase [Yarrowia lipolytica]
Length = 219
Score = 76.9 bits (186), Expect = 1e-13
Identities = 45/159 (28%), Positives = 76/159 (47%), Gaps = 10/159 (6%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
K++ + L +KFG F L SG+ S Y+ ++ L AL + + G+E
Sbjct: 5 KKDFLDLATKYEALKFGSFTLKSGRTSPYFFNL-GLFNTGVALSTVGASFAQVIINSGVE 63
Query: 62 YDKVAGPELGAVPIATALSLE---------TDKPLLIIRKKKKEHGTGKLIEGEISPGDR 112
+D + GP +P+A + + K RK+ K+HG G I G G +
Sbjct: 64 FDVIFGPAYKGIPLAAVTAAKIAELGGEKYATKEYAFNRKEAKDHGEGGNIVGASLKGKK 123
Query: 113 VLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
VL+++DV T G ++ A I+ +GA V + + +DR+E
Sbjct: 124 VLIIDDVITAGTAIKEAFSIIDANGATVSAVVIALDRQE 162
>sp|P42719|PYRE_RHILT OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|487440|gb|AAB52372.1| (U08434) orotate
phosphoribosyltransferase [Rhizobium trifolii]
Length = 223
Score = 76.5 bits (185), Expect = 2e-13
Identities = 52/157 (33%), Positives = 79/157 (50%), Gaps = 13/157 (8%)
Query: 1 MKEELVKLIIDSGCIKFGH---FILTSGKESNYYIDIKSLITNPKALKLIAKMIKEES-R 56
M E L K++ + + F + L SG S YID + L++ P+ + R
Sbjct: 12 MAELLAKMLWEIKAVHFNAAQPYKLASGMASPVYIDCRKLLSFPRIRSTVMDFAASTLLR 71
Query: 57 KLGIE-YDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
G E +D +AG E +P A L+ P++ +RK+ K HG IEG + G RVL+
Sbjct: 72 DAGFEQFDCIAGGETAGIPFAALLADRLGLPMIYVRKQPKGHGRNAQIEGNMPEGSRVLV 131
Query: 116 VEDVTTTGGSV------IRAAKILKEHGAEV--VGIF 144
+ED+TT GGS+ +RAA + +HG + GIF
Sbjct: 132 IEDLTTAGGSMFKFIDAVRAAGGIVDHGIALFFYGIF 168
>sp|P77889|PYRE_LACPL OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|482665|pir||A60993 orotate phosphoribosyltransferase
(EC 2.4.2.10) pyrE [validated] - Lactobacillus plantarum
>gi|1514606|emb|CAA91008.1| (Z54240) orotate
phosphoribosyltransferase [Lactobacillus plantarum]
>gi|227881|prf||1713271A orotate
phosphoribosyltransferase [Lactobacillus plantarum]
Length = 212
Score = 76.1 bits (184), Expect = 2e-13
Identities = 45/159 (28%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 20 FILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATAL 79
F SG +S Y D + I+ P + IA I ++ + +AG +P A +
Sbjct: 26 FTWASGIKSPIYTDNRLTISYPAVRQHIAHGIAAIIKREYPATEVIAGVATAGIPHAAWV 85
Query: 80 SLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAE 139
+ + PL+ +R K K+HG G+ IEG + PG +V++++D+ +TGGSV++AAK ++ G +
Sbjct: 86 AELLNLPLIYVRAKPKDHGAGRQIEGVLKPGQKVVMLDDLISTGGSVLQAAKAVQAAGGD 145
Query: 140 VVGIFVVVDRE-EGARENIEKEGFKLYPLVLVSDLFEAA 177
+ + + + A +N L+ L +L + A
Sbjct: 146 IQAVGAIFSYALDAATQNFAAASLPLFSLSNYPELIKVA 184
>sp|P43855|PYRE_HAEIN OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|1075093|pir||I64058 orotate
phosphoribosyltransferase (EC 2.4.2.10) HI0272
[similarity] - Haemophilus influenzae (strain Rd KW20)
>gi|1573238|gb|AAC21938.1| (U32713) orotate
phosphoribosyltransferase (pyrE) [Haemophilus influenzae
Rd]
Length = 213
Score = 75.7 bits (183), Expect = 3e-13
Identities = 42/156 (26%), Positives = 81/156 (51%), Gaps = 8/156 (5%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
K + ++ + +KFG F L SG++S Y+ + L L + + + ++
Sbjct: 5 KRDFIEFALSRNVLKFGEFTLKSGRKSPYFFNA-GLFNTGADLARLGEFYAAAIQASAVD 63
Query: 62 YDKVAGPELGAVPIATALSLET------DKPLLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D V GP +PI T++S+ DKP+ RK+ K+HG G + G G ++LL
Sbjct: 64 FDVVFGPAYKGIPIGTSVSVALFNRYGIDKPVCFNRKEVKDHGEGGNLIGSPLQG-KILL 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
V+DV T G ++ + +++ + AE+ + + ++R+E
Sbjct: 123 VDDVITAGTAIRESMELISANQAELAAVLIALNRKE 158
>sp|P57622|PYRE_BUCAI OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|10039215|dbj|BAB13249.1| (AP001119) orotate
phosphoribosyltransferase [Buchnera sp. APS]
Length = 213
Score = 74.1 bits (179), Expect = 9e-13
Identities = 52/190 (27%), Positives = 92/190 (48%), Gaps = 20/190 (10%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKL---IAKMIKEESRKL 58
K+E + +KFG F L SG+ S Y+ + L T +K+ A+ I + K
Sbjct: 4 KKEFIDFSFKKKVLKFGVFQLKSGRISPYFFNSGLLSTGIDIIKIGLFYARSIIDSKNK- 62
Query: 59 GIEYDKVAGPELGAVPIATALSL------ETDKPLLIIRKKKKEHGTGKLIEGEISPGDR 112
+D + GP +PIA A S+ + P RK+ KEHG + G R
Sbjct: 63 ---FDVLFGPAYKGIPIAVATSIALKNHYNLNVPYSFNRKEYKEHGEKGDLIGSTIYKKR 119
Query: 113 VLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENI-------EKEGFKLY 165
V++++DV T+G ++ + KI+++ A + IFV++DR+E + ++ +K+
Sbjct: 120 VIILDDVITSGTAIHHSIKIIEKQEASISSIFVLLDRKEKGIRKLSTINHFRNQKSYKII 179
Query: 166 PLVLVSDLFE 175
++ + DL E
Sbjct: 180 SIITIDDLIE 189
>emb|CAA32901.1| (X14795) orotate phosphoribosyltransferase (AA 1-226)
[Saccharomyces cerevisiae]
Length = 226
Score = 73.7 bits (178), Expect = 1e-12
Identities = 45/169 (26%), Positives = 85/169 (49%), Gaps = 11/169 (6%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
++ ++L I+ ++FG F L SG+ES Y+ ++ L K L +A + ++
Sbjct: 9 QKNFLELAIECQALRFGSFKLKSGRESPYFFNL-GLFNTGKLLSNLATAYAIAIIQSDLK 67
Query: 62 YDKVAGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIEGEISPGDR 112
+D + GP +P+A + ++ + RK+ K+HG G +I G R
Sbjct: 68 FDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVGSALENKR 127
Query: 113 VLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEG 161
+L+++DV T G ++ A +I+ +VVG + +DR+E + +KEG
Sbjct: 128 ILIIDDVMTAGTAINEAFEIISSAKGQVVGSIIALDRQEVVSTD-DKEG 175
>sp|P35788|PYRE_COLGR OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE) (OPRT)
>gi|419911|pir||S30118 orotate phosphoribosyltransferase
(EC 2.4.2.10) - anthracnose fungus (Colletotrichum
graminicola) >gi|259367|gb|AAB24061.1| (S47907) orotate
phosphoribosyl transferase, OPRTase [Colletotrichum
graminicola, Peptide, 233 aa] [Glomerella graminicola]
Length = 233
Score = 73.7 bits (178), Expect = 1e-12
Identities = 61/203 (30%), Positives = 96/203 (47%), Gaps = 28/203 (13%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNP--KALKLI-AKMIKEESRKL 58
K++ +K I +G +KFG F L S + S Y+ + +A+ L A + E
Sbjct: 9 KQDFLKAAI-AGVLKFGSFELKSKRISPYFFNAGDFYRADLLRAISLAYAHTVIEAREAT 67
Query: 59 GIEYDKVAGPELGAVPIATALS---LETDKPLL------IIRKKKKEHGTGKLIEGEISP 109
G+++D V GP +P+AT+ + E D RK+ K+HG G I G
Sbjct: 68 GLDFDVVFGPAYKGIPLATSTTDKLAELDPARYGTTCYSFDRKEAKDHGEGGNIVGAPLK 127
Query: 110 GDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE--------------GARE 155
G +VL+V+DV T G + A +++ G EVVGI V +DR E A
Sbjct: 128 GQKVLIVDDVITAGTAKREAIAKIRKEGGEVVGIVVALDRMEKLPAADGDDSKPGPSALG 187
Query: 156 NIEKE-GFKLYPLVLVSDLFEAA 177
I+KE G ++ ++ + D+ E A
Sbjct: 188 EIKKEYGIPIFSILTLDDIIEGA 210
>gi|6323530 Orotate phosphoribosyltransferase 1; Ura5p [Saccharomyces
cerevisiae] >gi|1346931|sp|P13298|PYRE_YEAST OROTATE
PHOSPHORIBOSYLTRANSFERASE 1 (OPRT)
>gi|1070467|pir||XJBY5 orotate phosphoribosyltransferase
(EC 2.4.2.10) URA5 [validated] - yeast (Saccharomyces
cerevisiae) >gi|798894|emb|CAA89112.1| (Z49210) Ura5p
[Saccharomyces cerevisiae]
Length = 226
Score = 73.7 bits (178), Expect = 1e-12
Identities = 45/169 (26%), Positives = 85/169 (49%), Gaps = 11/169 (6%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
++ ++L I+ ++FG F L SG+ES Y+ ++ L K L +A + ++
Sbjct: 9 QKNFLELAIECQALRFGSFKLKSGRESPYFFNL-GLFNTGKLLSNLATAYAIAIIQSDLK 67
Query: 62 YDKVAGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIEGEISPGDR 112
+D + GP +P+A + ++ + RK+ K+HG G +I G R
Sbjct: 68 FDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVGSALENKR 127
Query: 113 VLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEG 161
+L+++DV T G ++ A +I+ +VVG + +DR+E + +KEG
Sbjct: 128 ILIIDDVMTAGTAINEAFEIISNAKGQVVGSIIALDRQEVVSTD-DKEG 175
>sp|Q59049|APT_METJA ADENINE PHOSPHORIBOSYLTRANSFERASE (APRT) >gi|2127744|pir||E64506
probable hypoxanthine phosphoribosyltransferase (EC
2.4.2.8) MJ1655 [similarity] - Methanococcus jannaschii
>gi|1592237|gb|AAB99676.1| (U67606) adenine
phosphoribosyltransferase (apt) [Methanococcus
jannaschii]
Length = 183
Score = 73.7 bits (178), Expect = 1e-12
Identities = 47/145 (32%), Positives = 76/145 (52%), Gaps = 14/145 (9%)
Query: 38 ITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKE- 96
+ PK L+ +A I + G K+ E +P+ T LSL TD P +I+RK++ +
Sbjct: 31 VVEPKLLREVATRIIKIGDFEGAT--KLVTAEAMGIPLVTTLSLYTDIPYVIMRKREYKL 88
Query: 97 -----------HGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFV 145
+ G+L I GD+V++++DV +TGG++I LK GAE+ I
Sbjct: 89 PGEIPVFQSTGYSKGQLYLNGIEKGDKVVIIDDVISTGGTMIAIIDALKRAGAEIKDIIC 148
Query: 146 VVDREEGARENIEKEGFKLYPLVLV 170
V++R EG + EK G+K+ LV +
Sbjct: 149 VIERGEGKKIVEEKTGYKIKTLVKI 173
>pir||A29459 orotate phosphoribosyltransferase (EC 2.4.2.10) - Podospora
anserina >gi|225606|prf||1307195A orotidylic acid
pyrophosphorylase [Podospora anserina]
Length = 231
Score = 73.4 bits (177), Expect = 2e-12
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 12/161 (7%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
K++ +K ID +KFG F+L SG+ S Y+ + L I+ L I+
Sbjct: 8 KKDFLKSAIDGNILKFGSFLLKSGRTSPYFFNAGDFY-RADLLNSISTAYALTIDSLPIQ 66
Query: 62 YDKVAGPELGAVPIATALSLE-----------TDKPLLIIRKKKKEHGTGKLIEGEISPG 110
YD + GP +P+ATA +++ + L+ RK+ K+HG G I G G
Sbjct: 67 YDIIFGPAYKGIPLATAATIKLGQIRPRAKYAVGRVLVRDRKEAKDHGEGGNIVGAPLKG 126
Query: 111 DRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
RVL+V+DV + + A +++ G V GI V +DR E
Sbjct: 127 KRVLIVDDVISRCTAKREAIAKIEKEGGIVAGIVVALDRME 167
>sp|P08309|PYRE_PODAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE) (OPRT)
>gi|168997|gb|AAA33624.1| (M16697) orotidylic acid
pyrophosphorylase (EC 2.4.2.10) [Podospora anserina]
Length = 231
Score = 73.0 bits (176), Expect = 2e-12
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 12/161 (7%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
K++ +K ID +KFG F+L SG+ S Y+ + L I+ L I+
Sbjct: 8 KKDFLKSAIDGNILKFGSFLLKSGRTSPYFFNAGDFY-RADLLNSISTAYALTIDSLPIQ 66
Query: 62 YDKVAGPELGAVPIATALSLE-----------TDKPLLIIRKKKKEHGTGKLIEGEISPG 110
YD + GP +P+ATA +++ + L+ RK+ K+HG G I G G
Sbjct: 67 YDIIFGPAYKGIPLATAATIKLGQIRPRAKYAVGRVLVRDRKEAKDHGEGGNIVGAPLKG 126
Query: 111 DRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
RVL+V+DV + + + L++ G V GI V +DR E
Sbjct: 127 KRVLIVDDVISRCTAKREPSPRLEKEGGIVAGIVVALDRME 167
>emb|CAA46665.1| (X65783) URA5 [Saccharomyces cerevisiae]
Length = 214
Score = 73.0 bits (176), Expect = 2e-12
Identities = 45/165 (27%), Positives = 83/165 (50%), Gaps = 11/165 (6%)
Query: 6 VKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKV 65
++L I+ ++FG F L SG+ES Y+ ++ L K L +A + +++D +
Sbjct: 1 LELAIECQALRFGSFKLKSGRESPYFFNL-GLFNTGKLLSNLATAYAIAIIQSDLKFDVI 59
Query: 66 AGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIEGEISPGDRVLLV 116
GP +P+A + ++ + RK+ K+HG G +I G R+L++
Sbjct: 60 FGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVGSALENKRILII 119
Query: 117 EDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEKEG 161
+DV T G ++ A +I+ +VVG + +DR+E + +KEG
Sbjct: 120 DDVMTAGTAINEAFEIISNAKGQVVGSIIALDRQEVVSTD-DKEG 163
>sp|O13474|PYRE_KLULA OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE) (OPRT)
>gi|2415677|emb|CAA04694.1| (AJ001358)
orotate-phosphoribosyl-transferase [Kluyveromyces
lactis]
Length = 226
Score = 72.2 bits (174), Expect = 4e-12
Identities = 42/159 (26%), Positives = 81/159 (50%), Gaps = 10/159 (6%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
++ ++L I+S ++FG F L SG+ S Y+ ++ L K L +A + ++
Sbjct: 9 QKNFLELAIESKALRFGEFTLKSGRVSPYFFNL-GLFNTGKLLSNLATAYAIAIIQSELK 67
Query: 62 YDKVAGPELGAVPIATALSLET---------DKPLLIIRKKKKEHGTGKLIEGEISPGDR 112
+D + GP +P+A+ + ++ D RK+ K+HG G I G +
Sbjct: 68 FDVIFGPAYKGIPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVGAALKDQK 127
Query: 113 VLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
+L+++DV T G ++ A +I+ + +VVG + +DR+E
Sbjct: 128 ILIIDDVMTAGTAINEAFEIIAKEEGKVVGSIIALDRQE 166
>gi|6323927 Orotate phosphoribosyltransferase 2; Ura10p [Saccharomyces
cerevisiae] >gi|1172795|sp|P30402|PYRX_YEAST OROTATE
PHOSPHORIBOSYLTRANSFERASE 2 (OPRT)
>gi|2144405|pir||XJBY10 orotate
phosphoribosyltransferase (EC 2.4.2.10) URA10
[validated] - yeast (Saccharomyces cerevisiae)
>gi|4759|emb|CAA47016.1| (X66375) orotate
phosphoribosyltransferase [Saccharomyces cerevisiae]
>gi|809094|emb|CAA89254.1| (Z49260) Ura10p
[Saccharomyces cerevisiae]
Length = 227
Score = 71.8 bits (173), Expect = 5e-12
Identities = 48/167 (28%), Positives = 82/167 (48%), Gaps = 14/167 (8%)
Query: 3 EELVKLIIDSG----CIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKL 58
EE K ++ G ++FG F L SG++S Y+ ++ SL + K L +A +
Sbjct: 9 EEYQKTFLELGLECKALRFGSFKLNSGRQSPYFFNL-SLFNSGKLLANLATAYATAIIQS 67
Query: 59 GIEYDKVAGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIEGEISP 109
+++D + GP +P+A + ++ + RKK K+HG G +I G
Sbjct: 68 ELKFDVIFGPAYKGIPLAAIVCVKLAEIGGTKFQGIQYAFNRKKVKDHGEGGIIVGASLE 127
Query: 110 GDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGAREN 156
RVL+++DV T G ++ A +I+ VVG V +DR+E E+
Sbjct: 128 DKRVLIIDDVMTAGTAINEAFEIISIAQGRVVGCIVALDRQEVIHES 174
>pir||A30492 orotate phosphoribosyltransferase (EC 2.4.2.10) - Bacillus subtilis
Length = 210
Score = 71.4 bits (172), Expect = 6e-12
Identities = 42/146 (28%), Positives = 73/146 (49%), Gaps = 3/146 (2%)
Query: 1 MKEELVKLIIDSGCIKFGH---FILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRK 57
MK+ + K ++D + F SG S Y D + ++ P+ +A I + ++
Sbjct: 1 MKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNRLTLSFPEVRNDVASGISKLVKE 60
Query: 58 LGIEYDKVAGPELGAVPIATALSLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVE 117
E + +AG +P A + + P+ +R K K HG G IEG + G + +++E
Sbjct: 61 HFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSKPKAHGKGNQIEGAVQEGQKTVVIE 120
Query: 118 DVTTTGGSVIRAAKILKEHGAEVVGI 143
D+ +TGGSV+ A L+ G EV+G+
Sbjct: 121 DLISTGGSVLEACAALQAAGCEVLGV 146
>sp|O27375|APT_METTH ADENINE PHOSPHORIBOSYLTRANSFERASE (APRT) >gi|7450997|pir||E69042
hypoxanthine phosphoribosyltransferase (EC 2.4.2.8)
MTH1320 [similarity] - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622426|gb|AAB85798.1| (AE000896) adenine
phosphoribosyltransferase [Methanobacterium
thermoautotrophicum]
Length = 196
Score = 71.4 bits (172), Expect = 6e-12
Identities = 44/145 (30%), Positives = 77/145 (52%), Gaps = 15/145 (10%)
Query: 38 ITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATALSLETDKPLLIIRKKK--- 94
+T P+ L+ +A+ I R E DK+ E + AT LSL+T P +++RK++
Sbjct: 36 LTEPELLEEVAEEIVRRFRP---EADKIICIEAMGIHHATVLSLKTGIPFVVVRKRRYGL 92
Query: 95 ---------KEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFV 145
+ G+L + GDRV++++DV +TGG+++ + L+E +V +
Sbjct: 93 PGEVAVHQMTGYSEGELYINGVDSGDRVVVIDDVVSTGGTLLAVLEALREMDVDVRDVIT 152
Query: 146 VVDREEGARENIEKEGFKLYPLVLV 170
V+D+ EG+R E+ GF + LV V
Sbjct: 153 VIDKGEGSRVVRERTGFTVKSLVKV 177
>sp|P18904|PYRE_SORMA OROTATE PHOSPHORIBOSYLTRANSFERASE (OMPPPASE) (OPRT)
>gi|83848|pir||JS0175 orotate phosphoribosyltransferase
(EC 2.4.2.10) - Sordaria macrospora
>gi|530193|gb|AAA33929.1| (M26957) orotate
phosphoribosyl transferase [Sordaria macrospora]
Length = 232
Score = 71.0 bits (171), Expect = 8e-12
Identities = 55/163 (33%), Positives = 79/163 (47%), Gaps = 14/163 (8%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLI----AKMIKEESRK 57
K + +K ID G +KFG F L S + S Y+ + L+ I AK I E +
Sbjct: 7 KADFLKASIDGGVLKFGSFELKSKRISPYFFNAGDFY-RADLLQAISTAYAKCIIEAHKS 65
Query: 58 LGIEYDKVAGPELGAVPIATA-------LSLETDKPLLII--RKKKKEHGTGKLIEGEIS 108
+++D V GP +P+ATA L ET + RK+ K+HG G I G
Sbjct: 66 GQLDFDIVFGPAYKGIPLATAATDKLAQLDPETYGKICYSFDRKEAKDHGEGGNIVGAPL 125
Query: 109 PGDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
G R+L+V+DV T G + A +++ G V GI V +DR E
Sbjct: 126 KGKRILIVDDVITAGTAKREAIAKIEKEGGIVAGIVVALDRME 168
>sp|P25972|PYRE_BACSU OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE)
>gi|7427942|pir||F69686 orotate
phosphoribosyltransferase (EC 2.4.2.10) pyrE
[similarity] - Bacillus subtilis
>gi|143394|gb|AAA21274.1| (M59757) OMP-PRPP transferase
[Bacillus subtilis] >gi|2633929|emb|CAB13430.1| (Z99112)
orotate phosphoribosyltransferase [Bacillus subtilis]
Length = 216
Score = 71.0 bits (171), Expect = 8e-12
Identities = 38/124 (30%), Positives = 64/124 (50%)
Query: 20 FILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATAL 79
F SG S Y D + ++ P+ +A I + ++ E + +AG +P A
Sbjct: 29 FTWASGILSPIYCDNRLTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALA 88
Query: 80 SLETDKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAE 139
+ + P+ +R K K HG G IEG + G + +++ED+ +TGGSV+ A L+ G E
Sbjct: 89 ADHLNLPMCYVRSKPKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCE 148
Query: 140 VVGI 143
V+G+
Sbjct: 149 VLGV 152
>pir||T40667 orotate phosphoribosyltransferase (EC 2.4.2.10) SPBC725.15
[similarity] - fission yeast (Schizosaccharomyces pombe)
>gi|3925765|emb|CAA22187.1| (AL034352) orotate
phosphoribosyltransferase [Schizosaccharomyces pombe]
Length = 215
Score = 70.2 bits (169), Expect = 1e-11
Identities = 47/156 (30%), Positives = 83/156 (53%), Gaps = 7/156 (4%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIE 61
K EL++ ++ +KFG F L SG++S Y+ + + T+ L +A+ E + ++
Sbjct: 4 KLELLRRALEHNVLKFGTFTLKSGRKSPYFFNSGNF-THGADLCALAEAYAETIIAMNVD 62
Query: 62 YDKVAGPELGAVPIA--TALSL--ETDKP--LLIIRKKKKEHGTGKLIEGEISPGDRVLL 115
+D + GP + +A TA+ L +T K RK+ K HG G + G G +VLL
Sbjct: 63 FDVIFGPAYKGISLAAITAVKLYEKTGKSYGFAYNRKEAKSHGEGGNLVGAEMEGKKVLL 122
Query: 116 VEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
++DV T G ++ A L+ ++ GI +++DR+E
Sbjct: 123 LDDVITAGTAIREAISFLEPKHVKLAGIVLLLDRQE 158
>emb|CAA36440.1| (X52194) orotate phosphoribosyltransferase [Saccharomyces
cerevisiae]
Length = 227
Score = 69.9 bits (168), Expect = 2e-11
Identities = 47/167 (28%), Positives = 81/167 (48%), Gaps = 14/167 (8%)
Query: 3 EELVKLIIDSG----CIKFGHFILTSGKESNYYIDIKSLITNPKALKLIAKMIKEESRKL 58
EE K ++ G ++FG F L SG++S Y+ ++ SL + K L +A +
Sbjct: 9 EEYQKTFLELGLECKALRFGSFKLNSGRQSPYFFNL-SLFNSGKLLANLATAYATAIIQS 67
Query: 59 GIEYDKVAGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIEGEISP 109
+++D + GP +P+A + ++ + RKK K+HG G +I G
Sbjct: 68 ELKFDVIFGPAYKGIPLAAIVCVKLAEIGGTKFQGIQYAFNRKKVKDHGEGGIIVGASLE 127
Query: 110 GDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGAREN 156
RVL+++DV T G + A +I+ +VG V +DR+E E+
Sbjct: 128 DKRVLIIDDVMTAGTRINEAFEIISIAQGRLVGCIVALDRQEVIHES 174
>pir||T45214 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) [validated] -
Methanobacterium thermoautotrophicum (strain Marburg)
>gi|2232366|gb|AAB62272.1| (AF007759) purine
phosphoribosyltransferase [Methanobacterium
thermoautotrophicum]
Length = 193
Score = 69.9 bits (168), Expect = 2e-11
Identities = 43/143 (30%), Positives = 73/143 (50%), Gaps = 12/143 (8%)
Query: 38 ITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATALSLETDKPLLIIRKKK--- 94
+T P+ L+ IA I DK+ E + AT LSL+T P +++RK++
Sbjct: 33 LTEPELLEEIADEIVRRFNPDPASVDKIVCIEAMGIHHATVLSLKTRIPFVVVRKRRYGL 92
Query: 95 ---------KEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFV 145
+ G+L + DRV++++DV +TGG+++ + L+E EVV +
Sbjct: 93 PGEVAVHQMTGYSEGELYINGVDGDDRVMVIDDVVSTGGTLLAVLEALREMEVEVVDVVT 152
Query: 146 VVDREEGARENIEKEGFKLYPLV 168
V+D+ EG+R E+ GF + LV
Sbjct: 153 VIDKGEGSRVVKERTGFTVRSLV 175
>gb|AAB61216.1| (U24682) pyrimidine biosynthesis protein E [Enterococcus faecalis]
Length = 112
Score = 69.5 bits (167), Expect = 2e-11
Identities = 37/108 (34%), Positives = 63/108 (58%)
Query: 24 SGKESNYYIDIKSLITNPKALKLIAKMIKEESRKLGIEYDKVAGPELGAVPIATALSLET 83
SG +S Y D + ++ P K IA+ + + ++ E + +AG +P A ++
Sbjct: 4 SGIKSPIYCDNRITMSYPAVRKEIAEGLAAKIKETFPEVEVIAGTATAGIPHAAWVADIL 63
Query: 84 DKPLLIIRKKKKEHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAK 131
P++ IR K K+HG G IEG IS G +++++ED+ +TGGSV+ AA+
Sbjct: 64 GLPMVYIRSKAKDHGKGNQIEGRISEGQKMVVIEDLISTGGSVLEAAE 111
>gb|AAD01747.1| (AF022887) orotidine monophosphate pyrophosphorylase [Exophiala
dermatitidis]
Length = 245
Score = 68.7 bits (165), Expect = 4e-11
Identities = 49/189 (25%), Positives = 87/189 (45%), Gaps = 26/189 (13%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITN-----------------PKAL 44
K+ L+ L++ + + FG + L SG+ S Y+ L T+ P +L
Sbjct: 8 KKTLLPLLLKASVLSFGSYTLKSGRVSPYFFTSSLLHTSVLLGALARAYASVLTSPPFSL 67
Query: 45 KLIAKMIKEESR-KLGIEYDKVAGPELGAVPIATALSLETD--------KPLLIIRKKKK 95
L + E+ K ++D + GP +P+A ++ E + RK+ K
Sbjct: 68 PLATEEAGSEADGKSSPQFDILFGPAYKGIPLAAIVARELEFSGKHFEGVSYSFNRKEAK 127
Query: 96 EHGTGKLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARE 155
+HG G +I G G RV++++DV T G ++ A I+K G VVG+ +++ R+E E
Sbjct: 128 DHGEGGIIVGAPLKGKRVVVIDDVMTAGTALREAISIIKAQGGIVVGVVLLLTRQERVSE 187
Query: 156 NIEKEGFKL 164
+ K+
Sbjct: 188 TEPRSAMKV 196
>gb|AAD13717.1| (AF022892) orotidine monophosphate pyrophosphorylase [Coccidioides
immitis]
Length = 238
Score = 67.9 bits (163), Expect = 7e-11
Identities = 55/209 (26%), Positives = 91/209 (43%), Gaps = 32/209 (15%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYIDIKSLITNPK--------ALKLIAKMIKE 53
K L+ +I + + FG + L SG+ S Y+ L T P A L +
Sbjct: 8 KTNLLSHLISNKVLSFGSYTLKSGRNSPYFFTTTLLHTAPLLHATASACASVLSSPPFVT 67
Query: 54 ESRKLGI---EYDKVAGPELGAVPIATALSLE----------TDKPLLIIRKKKKEHGTG 100
S G +D + GP +P+ TA+ E + RK+ K HG G
Sbjct: 68 TSTPDGTPRPNFDIIFGPAYKGIPLCTAVLNELGVRDTTGAWNNISYSFNRKEAKAHGEG 127
Query: 101 KLIEGEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREEGARENIEK- 159
I G G ++++++DV T G ++ A I+++ G VVG+ V++DREE +N +K
Sbjct: 128 GNIVGAPLKGKKIVIIDDVITAGTALREAVGIIEKEGGTVVGVLVLLDREERVNDNEKKS 187
Query: 160 ----------EGFKLYPLVLVSDLFEAAG 178
E + ++ +SD+ E G
Sbjct: 188 AVGCAQRDLGENVPVKAVLSLSDIIEKLG 216
>gb|AAC62627.1| (AF070928) orotidine-5'-monophosphate pyrophosphorylase
[Ajellomyces capsulatus]
Length = 244
Score = 67.5 bits (162), Expect = 9e-11
Identities = 46/167 (27%), Positives = 80/167 (47%), Gaps = 20/167 (11%)
Query: 2 KEELVKLIIDSGCIKFGHFILTSGKESNYYID--------IKSLITNPKALKLIAKMIKE 53
K ++ + + +KFG F L SG++S Y+ + + S I+ A +++ +
Sbjct: 15 KTTFLESCLSANVLKFGVFTLKSGRKSPYFFNAGLFHTSSLLSAISTAYANTIVSYLASN 74
Query: 54 ESRKLGIEYDKVAGPELGAVPIATALSLETDK---------PLLIIRKKKKEHGTGKLIE 104
S ++ D + GP +P+A A LE + RK+ K+HG G I
Sbjct: 75 PSI---LKPDVIFGPAYKGIPLACATLLELHRMDPATWSSVSYSYNRKEAKDHGEGGSIV 131
Query: 105 GEISPGDRVLLVEDVTTTGGSVIRAAKILKEHGAEVVGIFVVVDREE 151
G G VL+++DV T G ++ K++ + G +VVG V +DR+E
Sbjct: 132 GSPLKGKNVLVIDDVITAGTAMRETLKLVDKEGGKVVGFVVALDRQE 178
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.315 0.139 0.374
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65366551
Number of Sequences: 2977
Number of extensions: 2567657
Number of successful extensions: 6759
Number of sequences better than 1.0e-10: 84
Number of HSP's better than 0.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 6616
Number of HSP's gapped (non-prelim): 87
length of query: 182
length of database: 189,106,746
effective HSP length: 58
effective length of query: 124
effective length of database: 154,394,500
effective search space: 19144918000
effective search space used: 19144918000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 162 (67.5 bits)