BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB2432 (thiM) DE:hydroxyethylthiazole kinase (thiM)
         (268 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

sp|Q9UZQ4|THIM_PYRAB HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   525  e-148
sp|O58877|THIM_PYRHO HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   432  e-120
sp|P39593|THIM_BACSU HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   207  9e-53
pdb|1ESJ|A Chain A, Crystal Structure Of Thiazole Kinase Mutant ...   203  1e-51
pdb|1EKK|A Chain A, Crystal Structure Of Hydroxyethylthiazole Ki...   203  2e-51
dbj|BAB07068.1| (AP001518) hydroxyethylthiazole kinase [Bacillus...   192  3e-48
gi|11499657 hydroxyethylthiazole kinase (thiM) [Archaeoglobus fu...   189  2e-47
sp|Q57233|THIM_HAEIN HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   183  1e-45
dbj|BAB03021.1| (AP001297) hydoxyethylthiazole kinase-like prote...   180  1e-44
sp|Q9RGS6|THIM_STACA HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   170  2e-41
sp|Q9ZKZ9|THIM_HELPJ HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   156  3e-37
sp|P40386|THI4_SCHPO PROBABLE THIAMINE BIOSYNTHETIC BIFUNCTIONAL...   155  4e-37
pir||E64625 hydroxyethylthiazole kinase (EC 2.7.1.50) - Helicoba...   154  1e-36
sp|O25516|THIM_HELPY HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   154  1e-36
sp|P76423|THIM_ECOLI HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   146  2e-34
sp|P55883|THIM_SALTY HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BET...   145  5e-34
dbj|BAA76743.1| (D88442) hydoxyethylthiazole kinase [Escherichia...   134  8e-31
dbj|BAA89257.1| (AB024693) OrfG [Leptospira interrogans serovar ...   127  1e-28
gi|6325042 TMP pyrophosphorylase, hydroxyethylthiazole kinase; T...    99  5e-20

>sp|Q9UZQ4|THIM_PYRAB HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE) >gi|7434092|pir||E75087
           hydroxyethylthiazole kinase (thim) PAB2432 - Pyrococcus
           abyssi (strain Orsay) >gi|5458514|emb|CAB50002.1|
           (AJ248286) hydroxyethylthiazole kinase (thiM)
           [Pyrococcus abyssi]
           Length = 268
           
 Score =  525 bits (1338), Expect = e-148
 Identities = 268/268 (100%), Positives = 268/268 (100%)

Query: 1   MNALNFIVEALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLA 60
           MNALNFIVEALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLA
Sbjct: 1   MNALNFIVEALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLA 60

Query: 61  DAVVINIGTLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVL 120
           DAVVINIGTLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVL
Sbjct: 61  DAVVINIGTLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVL 120

Query: 121 KGNFGEISSLLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKV 180
           KGNFGEISSLLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKV
Sbjct: 121 KGNFGEISSLLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKV 180

Query: 181 FAIYNGHKLLERVTGTGCIVTAITGAFVAVTEPLRAAISSLVVFGIAAEKAYEEAKYPGS 240
           FAIYNGHKLLERVTGTGCIVTAITGAFVAVTEPLRAAISSLVVFGIAAEKAYEEAKYPGS
Sbjct: 181 FAIYNGHKLLERVTGTGCIVTAITGAFVAVTEPLRAAISSLVVFGIAAEKAYEEAKYPGS 240

Query: 241 FHVKLYDWLYRIDGEVIRKYAKVREVGV 268
           FHVKLYDWLYRIDGEVIRKYAKVREVGV
Sbjct: 241 FHVKLYDWLYRIDGEVIRKYAKVREVGV 268


>sp|O58877|THIM_PYRHO HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE) >gi|7434093|pir||G71057
           hypothetical protein PH1157 - Pyrococcus horikoshii
           >gi|3257574|dbj|BAA30257.1| (AP000005) 265aa long
           hypothetical protein [Pyrococcus horikoshii]
           Length = 265
           
 Score =  432 bits (1098), Expect = e-120
 Identities = 216/263 (82%), Positives = 238/263 (90%)

Query: 4   LNFIVEALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAV 63
           + FI+EAL  VR+R+PLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMI LADAV
Sbjct: 1   MKFIIEALKRVRERRPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIRLADAV 60

Query: 64  VINIGTLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVLKGN 123
           VINIGTLDS WR+SM+KA EIANE+ KPIVLDPVGAGATK RT+V+LEIL RGV VLKGN
Sbjct: 61  VINIGTLDSGWRRSMVKATEIANELGKPIVLDPVGAGATKFRTRVSLEILSRGVDVLKGN 120

Query: 124 FGEISSLLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAI 183
           FGEIS+LLGE GKTRGVDS EY EE+AK L ++AA+EFNTTVAVTGAVDYVSDG + FA+
Sbjct: 121 FGEISALLGEEGKTRGVDSLEYGEEEAKKLTMNAAREFNTTVAVTGAVDYVSDGRRTFAV 180

Query: 184 YNGHKLLERVTGTGCIVTAITGAFVAVTEPLRAAISSLVVFGIAAEKAYEEAKYPGSFHV 243
           YNGH+LL RVTGTGC+V A+TGAFVAVTEPL+A  S+LV FGIAAEKAYEEAKYPGSFHV
Sbjct: 181 YNGHELLGRVTGTGCMVAALTGAFVAVTEPLKATTSALVTFGIAAEKAYEEAKYPGSFHV 240

Query: 244 KLYDWLYRIDGEVIRKYAKVREV 266
           KLYDWLYRI+  VIR YAKVREV
Sbjct: 241 KLYDWLYRINENVIRTYAKVREV 263


>sp|P39593|THIM_BACSU HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE) >gi|629032|pir||S39680
           hydroxyethylthiazole kinase (EC 2.7.1.50) thiK -
           Bacillus subtilis >gi|5821947|pdb|1C3Q|A Chain A,
           Crystal Structure Of Native Thiazole Kinase In The
           Monoclinic Form >gi|5821949|pdb|1C3Q|B Chain B, Crystal
           Structure Of Native Thiazole Kinase In The Monoclinic
           Form >gi|5821951|pdb|1C3Q|C Chain C, Crystal Structure
           Of Native Thiazole Kinase In The Monoclinic Form
           >gi|413949|emb|CAA51581.1| (X73124) ipa-25d [Bacillus
           subtilis] >gi|2636365|emb|CAB15856.1| (Z99123)
           hydroxyethylthiazole kinase [Bacillus subtilis]
           Length = 272
           
 Score =  207 bits (522), Expect = 9e-53
 Identities = 118/265 (44%), Positives = 178/265 (66%), Gaps = 6/265 (2%)

Query: 9   EALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIG 68
           + L  VR+  PLVH+ITN VV N TAN LLALGASPVMA+A+EE+ +M  +A A+V+NIG
Sbjct: 8   KCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPVMAYAKEEVADMAKIAGALVLNIG 67

Query: 69  TLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEIL-DRGVTVLKGNFGEI 127
           TL     ++MI A + ANE   P++LDPVGAGAT  RT+ A +I+ +  +  ++GN  EI
Sbjct: 68  TLSKESVEAMIIAGKSANEHGVPVILDPVGAGATPFRTESARDIIREVRLAAIRGNAAEI 127

Query: 128 SSLLGEFG-KTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNG 186
           +  +G      +GVD+ E   +  + LA  AA++ NT +A+TG VD ++D   V+ ++NG
Sbjct: 128 AHTVGVTDWLIKGVDAGEGGGDIIR-LAQQAAQKLNTVIAITGEVDVIADTSHVYTLHNG 186

Query: 187 HKLLERVTGTGCIVTAITGAFVAVTE-PLRAAISSLVVFGIAAEKAYEEA--KYPGSFHV 243
           HKLL +VTG GC++T++ GAF AV E PL AAI+++  +G+AA+ A ++   K PGSF +
Sbjct: 187 HKLLTKVTGAGCLLTSVVGAFCAVEENPLFAAIAAISSYGVAAQLAAQQTADKGPGSFQI 246

Query: 244 KLYDWLYRIDGEVIRKYAKVREVGV 268
           +L + L  +  + ++++A +  V V
Sbjct: 247 ELLNKLSTVTEQDVQEWATIERVTV 271


>pdb|1ESJ|A Chain A, Crystal Structure Of Thiazole Kinase Mutant (C198s)
           >gi|10121010|pdb|1ESJ|B Chain B, Crystal Structure Of
           Thiazole Kinase Mutant (C198s) >gi|10121011|pdb|1ESJ|C
           Chain C, Crystal Structure Of Thiazole Kinase Mutant
           (C198s) >gi|10121012|pdb|1ESQ|A Chain A, Crystal
           Structure Of Thiazole Kinase Mutant (C198s) With Atp And
           Thiazole Phosphate. >gi|10121013|pdb|1ESQ|B Chain B,
           Crystal Structure Of Thiazole Kinase Mutant (C198s) With
           Atp And Thiazole Phosphate. >gi|10121014|pdb|1ESQ|C
           Chain C, Crystal Structure Of Thiazole Kinase Mutant
           (C198s) With Atp And Thiazole Phosphate
           Length = 284
           
 Score =  203 bits (512), Expect = 1e-51
 Identities = 117/265 (44%), Positives = 177/265 (66%), Gaps = 6/265 (2%)

Query: 9   EALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIG 68
           + L  VR+  PLVH+ITN VV N TAN LLALGASPVMA+A+EE+ +M  +A A+V+NIG
Sbjct: 20  KCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPVMAYAKEEVADMAKIAGALVLNIG 79

Query: 69  TLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEIL-DRGVTVLKGNFGEI 127
           TL     ++MI A + ANE   P++LDPVGAGAT  RT+ A +I+ +  +  ++GN  EI
Sbjct: 80  TLSKESVEAMIIAGKSANEHGVPVILDPVGAGATPFRTESARDIIREVRLAAIRGNAAEI 139

Query: 128 SSLLGEFG-KTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNG 186
           +  +G      +GVD+ E   +  + LA  AA++ NT +A+TG VD ++D   V+ ++NG
Sbjct: 140 AHTVGVTDWLIKGVDAGEGGGDIIR-LAQQAAQKLNTVIAITGEVDVIADTSHVYTLHNG 198

Query: 187 HKLLERVTGTGCIVTAITGAFVAVTE-PLRAAISSLVVFGIAAEKAYEEA--KYPGSFHV 243
           HKLL +VTG G ++T++ GAF AV E PL AAI+++  +G+AA+ A ++   K PGSF +
Sbjct: 199 HKLLTKVTGAGSLLTSVVGAFCAVEENPLFAAIAAISSYGVAAQLAAQQTADKGPGSFQI 258

Query: 244 KLYDWLYRIDGEVIRKYAKVREVGV 268
           +L + L  +  + ++++A +  V V
Sbjct: 259 ELLNKLSTVTEQDVQEWATIERVTV 283


>pdb|1EKK|A Chain A, Crystal Structure Of Hydroxyethylthiazole Kinase In The R3
           Form With Hydroxyethylthiazole >gi|10120993|pdb|1EKK|B
           Chain B, Crystal Structure Of Hydroxyethylthiazole
           Kinase In The R3 Form With Hydroxyethylthiazole
           >gi|10120994|pdb|1EKQ|A Chain A, Crystal Structure Of
           Hydroxyethylthiazole Kinase In R3 Space Group
           >gi|10120995|pdb|1EKQ|B Chain B, Crystal Structure Of
           Hydroxyethylthiazole Kinase In R3 Space Group
           Length = 272
           
 Score =  203 bits (511), Expect = 2e-51
 Identities = 117/265 (44%), Positives = 177/265 (66%), Gaps = 6/265 (2%)

Query: 9   EALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIG 68
           + L  VR+  PLVH+ITN VV N TAN LLALGASPVMA+A+EE+ +M  +A A+V+NIG
Sbjct: 8   KCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPVMAYAKEEVADMAKIAGALVLNIG 67

Query: 69  TLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEIL-DRGVTVLKGNFGEI 127
           TL     ++MI A + ANE   P++LDPVGAGAT  RT+ A +I+ +  +  ++GN  EI
Sbjct: 68  TLSKESVEAMIIAGKSANEHGVPVILDPVGAGATPFRTESARDIIREVRLAAIRGNAAEI 127

Query: 128 SSLLGEFG-KTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNG 186
           +  +G      +GVD+ E   +  + LA  AA++ NT +A+TG VD ++D   V+ ++NG
Sbjct: 128 AHTVGVTDWLIKGVDAGEGGGDIIR-LAQQAAQKLNTVIAITGEVDVIADTSHVYTLHNG 186

Query: 187 HKLLERVTGTGCIVTAITGAFVAVTE-PLRAAISSLVVFGIAAEKAYEEA--KYPGSFHV 243
           HKLL +VTG G ++T++ GAF AV E PL AAI+++  +G+AA+ A ++   K PGSF +
Sbjct: 187 HKLLTKVTGAGXLLTSVVGAFCAVEENPLFAAIAAISSYGVAAQLAAQQTADKGPGSFQI 246

Query: 244 KLYDWLYRIDGEVIRKYAKVREVGV 268
           +L + L  +  + ++++A +  V V
Sbjct: 247 ELLNKLSTVTEQDVQEWATIERVTV 271


>dbj|BAB07068.1| (AP001518) hydroxyethylthiazole kinase [Bacillus halodurans]
           Length = 261
           
 Score =  192 bits (484), Expect = 3e-48
 Identities = 117/258 (45%), Positives = 164/258 (63%), Gaps = 7/258 (2%)

Query: 10  ALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGT 69
           ++  +RK  PL+H +TN VV N TAN LLA+GASPVMA+A+EE+ +M  +A+A+++NIGT
Sbjct: 2   SIEMLRKSNPLIHCMTNVVVTNFTANGLLAVGASPVMAYAKEEVADMAKVANALLLNIGT 61

Query: 70  LDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEIL-DRGVTVLKGNFGEIS 128
           L +    +MI A + AN+   P+VLDPVGAGAT  RT+    IL +  VT+++GN GEI+
Sbjct: 62  LSAESIDNMIIAGKAANKAGAPVVLDPVGAGATVFRTESCKRILKEVDVTIVRGNGGEIA 121

Query: 129 SLLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHK 188
           +L  + G  +GVD S  D +  + LA  AA   N+ V VTG VD V+DG      YNGH 
Sbjct: 122 ALSDQAGTVKGVDGS-IDSDPVE-LAKHAANVLNSAVVVTGEVDVVTDGTGTVCGYNGHP 179

Query: 189 LLERVTGTGCIVTAITGAFVAV-TEPLRAAIS-SLVVFGIAAEKAYEE--AKYPGSFHVK 244
            L +V GTGC+  AI  AF ++ T+     I   LV +G+AAEKAYEE  AK  GSF   
Sbjct: 180 WLTKVVGTGCLSGAIVAAFASLKTDDFLEVIGYGLVAYGVAAEKAYEETKAKGYGSFQTA 239

Query: 245 LYDWLYRIDGEVIRKYAK 262
             + L R+  E ++++ +
Sbjct: 240 FLNQLGRLTDEDVKQHGR 257


>gi|11499657 hydroxyethylthiazole kinase (thiM) [Archaeoglobus fulgidus]
           >gi|9910883|sp|O28204|THIM_ARCFU HYDROXYETHYLTHIAZOLE
           KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE KINASE)
           (THZ KINASE) (TH KINASE) >gi|7434091|pir||B69509
           hydroxyethylthiazole kinase (EC 2.7.1.50) -
           Archaeoglobus fulgidus >gi|2648451|gb|AAB89174.1|
           (AE000960) hydroxyethylthiazole kinase (thiM)
           [Archaeoglobus fulgidus]
           Length = 268
           
 Score =  189 bits (476), Expect = 2e-47
 Identities = 101/241 (41%), Positives = 156/241 (63%), Gaps = 4/241 (1%)

Query: 18  KPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTLDSWWRKS 77
           KP+VH+ITN+V MN +AN  +A+GASP+M+ A  E++E++ +A +++INIGTLD +  ++
Sbjct: 21  KPVVHHITNYVAMNDSANITIAIGASPIMSFAHGEIDELVSIASSLLINIGTLDEYIIQA 80

Query: 78  MIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVLKGNFGEISSLLGEFGKT 137
           ++ AV+ A     P++LDPVG+GATKLRT  AL + + GV V+KGN GEI SLL + G  
Sbjct: 81  VMLAVKSAKSKGVPVLLDPVGSGATKLRTSTALSVAEEGVDVIKGNQGEILSLLRKEGVV 140

Query: 138 RGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKLLERVTGTG 197
           RGVD S+   E A V     A++F   V  TG  D +SDG  V+ + NG ++L R+T +G
Sbjct: 141 RGVD-SKVTAEAADV--KEVARKFGLVVVATGKEDLISDGRSVYVMRNGTEMLGRITASG 197

Query: 198 CIVTAITGAFVAVTEP-LRAAISSLVVFGIAAEKAYEEAKYPGSFHVKLYDWLYRIDGEV 256
           C++ ++  +F+AV +  L A++  L  + +A E A E++    SF   L D + +I  E 
Sbjct: 198 CMLGSVIASFMAVQKDFLLASLEGLACYNVAGELAAEKSSGTASFRSNLIDEISKITAEK 257

Query: 257 I 257
           +
Sbjct: 258 V 258


>sp|Q57233|THIM_HAEIN HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE) >gi|1074395|pir||H64151
           hydroxyethylthiazole kinase (EC 2.7.1.50) - Haemophilus
           influenzae (strain Rd KW20) >gi|1573389|gb|AAC22073.1|
           (U32725) hydroxyethylthiazole kinase [Haemophilus
           influenzae Rd]
           Length = 265
           
 Score =  183 bits (461), Expect = 1e-45
 Identities = 102/259 (39%), Positives = 164/259 (62%), Gaps = 5/259 (1%)

Query: 11  LNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTL 70
           L+++R++ PL+HNITN V  N +AN LLALGASP+M+   EE++E+  ++ A+VINIGTL
Sbjct: 8   LSKIREQNPLIHNITNIVAANFSANGLLALGASPLMSANVEEMQEVPKISQALVINIGTL 67

Query: 71  DSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEIL-DRGVTVLKGNFGEISS 129
               R++M++A + ANE+  P+VLDPVG GAT  R +   E+L +    +++GN GE+++
Sbjct: 68  IGKDREAMLQAGKTANEVGIPVVLDPVGVGATSYRRETIRELLAEVKFALIRGNAGELAA 127

Query: 130 LLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKL 189
           + GE  + +GVD+ +  E   K +A   A+ +  TV ++GAVD VSDG +   ++NG  L
Sbjct: 128 IAGETWQAKGVDAGQ-GEVDLKAVAEKVAQRYGCTVLISGAVDIVSDGTQTATVHNGTSL 186

Query: 190 LERVTGTGCIVTAITGAFVAVTEP--LRAAISSLVVFGIAAEKAYEE-AKYPGSFHVKLY 246
             +VT +GC+++A+  AF+AV+E     A + + V + IA E A +      G F ++L 
Sbjct: 187 FPKVTASGCLLSAVCAAFLAVSEGNYFSATLEACVAYTIAGECAAQGLTTQVGQFQIRLL 246

Query: 247 DWLYRIDGEVIRKYAKVRE 265
           D L  +  E I +  ++ E
Sbjct: 247 DELAALSPETIGQRGRINE 265


>dbj|BAB03021.1| (AP001297) hydoxyethylthiazole kinase-like protein [Arabidopsis
           thaliana]
           Length = 276
           
 Score =  180 bits (453), Expect = 1e-44
 Identities = 103/260 (39%), Positives = 150/260 (57%), Gaps = 4/260 (1%)

Query: 11  LNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTL 70
           L  VR++ PLV  ITNFV M+  AN LL+ GASP M H+  E+ +      A+ +N+GTL
Sbjct: 18  LTAVRQQSPLVQCITNFVSMDLVANTLLSAGASPAMVHSVVEIPDFTPHIHALCVNVGTL 77

Query: 71  DSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVLKGNFGEISSL 130
              W  SM  A E+A++++KP VLDP     +  R K  LE+++   TV+KGN  EI +L
Sbjct: 78  TPDWLPSMKAAAELASQLRKPWVLDPAAVSCSGFRLKACLELIELKPTVIKGNGSEIIAL 137

Query: 131 -LGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKL 189
                G+T+G DSS ++   A   A S A      VAV+GAVD V+DG +V  ++NG K+
Sbjct: 138 SSASRGQTKGADSS-HESTDAIEAAKSLAMSSGAVVAVSGAVDIVTDGKQVIGVHNGTKM 196

Query: 190 LERVTGTGCIVTAITGAFVAV--TEPLRAAISSLVVFGIAAEKAYEEAKYPGSFHVKLYD 247
           ++++T TGC +  +  AF+A+  +  L A +S++ VFGIA E     A  P S  + L D
Sbjct: 197 MQQITATGCSLAGLIVAFLAIDSSRVLEATVSAMAVFGIAGELGEAMANGPASLRMHLID 256

Query: 248 WLYRIDGEVIRKYAKVREVG 267
            LY +D   + K   V  +G
Sbjct: 257 CLYGLDETTVLKRVNVTRLG 276


>sp|Q9RGS6|THIM_STACA HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE)
           >gi|6707003|gb|AAF25543.1|AF109218_3 (AF109218) ThiM
           [Staphylococcus carnosus]
           Length = 264
           
 Score =  170 bits (426), Expect = 2e-41
 Identities = 101/261 (38%), Positives = 151/261 (57%), Gaps = 7/261 (2%)

Query: 11  LNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTL 70
           L+++R   PLV   TN VV N TAN LL+LGASP M+ A +E E+   +A +V+INIGTL
Sbjct: 5   LDQIRTEHPLVICYTNDVVKNFTANGLLSLGASPTMSEAPQEAEDFYPVAGSVLINIGTL 64

Query: 71  DSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDR-GVTVLKGNFGEISS 129
                 +M++  +IANE + P+V DPV  GA+K R       L +   TV+KGN  EI +
Sbjct: 65  TKHHEHAMLENAKIANETETPLVFDPVAVGASKYRKDFCKYFLKKIKPTVIKGNASEILA 124

Query: 130 LLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKL 189
           L+ +    +G DS+  D      +A  A KE+ T + +TG  D +    KV  + NG   
Sbjct: 125 LIDDTATMKGTDSA--DNLDVVDIAEKAYKEYQTAIILTGETDVIVQDNKVVKLSNGSHF 182

Query: 190 LERVTGTGCIVTAITGAFV-AVTEP-LRAAISSLVVFGIAAEKAYE--EAKYPGSFHVKL 245
           L ++TG GC++ A+ GAF+   T P +   I ++ V+ IAAE+A +  ++K PG+F  + 
Sbjct: 183 LAKITGAGCLLGAVVGAFLFRNTHPSIETLIEAVSVYNIAAERAEQLSDSKGPGTFLTQF 242

Query: 246 YDWLYRIDGEVIRKYAKVREV 266
            D LYRID + + +   + EV
Sbjct: 243 IDALYRIDSDAVAENCNLEEV 263


>sp|Q9ZKZ9|THIM_HELPJ HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE) >gi|7434090|pir||A71890
           hydroxyethylthiazole kinase - Helicobacter pylori
           (strain J99) >gi|4155339|gb|AAD06352.1| (AE001508)
           HYDROXYETHYLTHIAZOLE KINASE [Helicobacter pylori J99]
           Length = 259
           
 Score =  156 bits (390), Expect = 3e-37
 Identities = 91/237 (38%), Positives = 142/237 (59%), Gaps = 8/237 (3%)

Query: 11  LNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTL 70
           L E+R+++PLVHNITN+VV    AN LLALG SP+M+ A  E+ ++  ++DA+ INIGTL
Sbjct: 2   LKELRQKRPLVHNITNYVVAQFVANGLLALGVSPLMSDAIAEMPDLAKISDALAINIGTL 61

Query: 71  DSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILD-RGVTVLKGNFGEISS 129
           +        +A++    + KPIVLDPVG  A+ LR   +LE+L+ +G++ L+GN  E+ S
Sbjct: 62  NERTILCAKEAIKRYKALNKPIVLDPVGCSASALRYDTSLELLESKGISTLRGNAAELGS 121

Query: 130 LLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKL 189
           L+G   +++G+DS          +   AA++++    +TG  DYVSDG KV +I  G + 
Sbjct: 122 LVGISCESKGLDSKH--SATPIEIVKRAAQKYSVIAVMTGKTDYVSDGKKVLSITGGSEY 179

Query: 190 LERVTGTGCIVTAITGAFVAV-TEPLRAAISSLVVFGIAA----EKAYEEAKYPGSF 241
           L  +TG GC+  A   +F+++  +PL + +     +  AA    +KA E     GSF
Sbjct: 180 LAAITGAGCLHAAACASFLSLKKDPLDSMVQLCAFYKQAAFSAQKKALENNGSNGSF 236


>sp|P40386|THI4_SCHPO PROBABLE THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME [INCLUDES:
           THIAMINE-PHOSPHATE PYROPHOSPHORYLASE (TMP
           PYROPHOSPHORYLASE) (TMP-PPASE); HYDROXYETHYLTHIAZOLE
           KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE KINASE)
           (THZ KINASE) (TH KINASE)] >gi|629908|pir||S44183
           thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) /
           hydroxyethylthiazole kinase (EC 2.7.1.50) thi4 - fission
           yeast (Schizosaccharomyces pombe)
           >gi|473357|emb|CAA55402.1| (X78824) thi4
           [Schizosaccharomyces pombe] >gi|2388929|emb|CAB11664.1|
           (Z98977) probable thiamine biosynthetic bifunctional
           enzyme [includes:thiamine-phosphate pyrophosphorylase]
           [Schizosaccharomyces pombe]
           Length = 518
           
 Score =  155 bits (389), Expect = 4e-37
 Identities = 96/267 (35%), Positives = 153/267 (56%), Gaps = 14/267 (5%)

Query: 4   LNFIVEALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAV 63
           LN I  AL +++   PL+H++TN V  N +AN  LA   SP M  + +E+ +      A+
Sbjct: 239 LNQIPAALQKLKDFTPLIHHLTNAVAKNFSANVTLAAYGSPTMGESYDEVADFAKAPGAL 298

Query: 64  VINIGTLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRG-VTVLKG 122
           V+NIG L++   K+ I A ++ N++ +P++LDPV  GAT  R+KV   +L+     ++KG
Sbjct: 299 VLNIGILEN--TKTYIHAAQVNNDLARPVILDPVAVGATTARSKVINTLLNYAYYDIIKG 356

Query: 123 NFGEISSLLGEFGKTRGVDSSEYDEEKAKVLAL-SAAKEFNTTVAVTGAVDYVSDGGKVF 181
           N GEI +L GE G  RGVDS       A++ A+   A E    VA++GAVD +SDG   +
Sbjct: 357 NEGEIMNLAGEQGLMRGVDSISQHTLAARITAVHRLAVERRCVVAMSGAVDVISDGNSTY 416

Query: 182 AIYNGHKLLERVTGTGCIVTAITG--AFVAVTEPLRAAISSLVVFGIAAEKAYEE----- 234
            I NG+ LL ++T +GC + ++ G  A +   + L AAI++ +++ IA+E A E      
Sbjct: 417 VIKNGNPLLGQITASGCSLGSVMGVTASICQNDKLLAAITATLLYNIASELAVEAKNSCG 476

Query: 235 ---AKYPGSFHVKLYDWLYRIDGEVIR 258
               + PG+F     D L+++  E I+
Sbjct: 477 DLLVQGPGTFIPIFVDKLHQLINETIK 503


>pir||E64625 hydroxyethylthiazole kinase (EC 2.7.1.50) - Helicobacter pylori
           (strain 26695) >gi|2313976|gb|AAD07891.1| (AE000595)
           thiamin phosphate pyrophosphorylase/hyroxyethylthiazole
           kinase (thiM) [Helicobacter pylori 26695]
           Length = 273
           
 Score =  154 bits (385), Expect = 1e-36
 Identities = 91/237 (38%), Positives = 142/237 (59%), Gaps = 8/237 (3%)

Query: 11  LNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTL 70
           L E+R+++PLVHNITN+V     AN LLALGASP+M+ A +E+ ++  ++DA+ INIGTL
Sbjct: 16  LKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMRDLAKISDALAINIGTL 75

Query: 71  DSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEIL-DRGVTVLKGNFGEISS 129
           +        +A++    + KPIVLDPVG  A+ LR   +LE+L   G++ L+GN  E+ S
Sbjct: 76  NDRAILCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGS 135

Query: 130 LLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKL 189
           L+G   +++G+DS+  D      +   AA++++    +TG  DYVSDG KV +I  G + 
Sbjct: 136 LVGISCESKGLDSN--DAATPVEIIKLAAQKYSVIAVMTGKTDYVSDGKKVLSITGGSEY 193

Query: 190 LERVTGTGCIVTAITGAFVAV-TEPLRAAISSLVVFGIAA----EKAYEEAKYPGSF 241
           L  +TG GC+  A   +F+++  +PL +      ++  AA    +K  E     GSF
Sbjct: 194 LALITGAGCLHAAACASFLSLKKDPLDSMAQLCALYKQAAFNAQKKVLENNGSNGSF 250


>sp|O25516|THIM_HELPY HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE)
           Length = 259
           
 Score =  154 bits (385), Expect = 1e-36
 Identities = 91/237 (38%), Positives = 142/237 (59%), Gaps = 8/237 (3%)

Query: 11  LNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTL 70
           L E+R+++PLVHNITN+V     AN LLALGASP+M+ A +E+ ++  ++DA+ INIGTL
Sbjct: 2   LKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMRDLAKISDALAINIGTL 61

Query: 71  DSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEIL-DRGVTVLKGNFGEISS 129
           +        +A++    + KPIVLDPVG  A+ LR   +LE+L   G++ L+GN  E+ S
Sbjct: 62  NDRAILCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGS 121

Query: 130 LLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKL 189
           L+G   +++G+DS+  D      +   AA++++    +TG  DYVSDG KV +I  G + 
Sbjct: 122 LVGISCESKGLDSN--DAATPVEIIKLAAQKYSVIAVMTGKTDYVSDGKKVLSITGGSEY 179

Query: 190 LERVTGTGCIVTAITGAFVAV-TEPLRAAISSLVVFGIAA----EKAYEEAKYPGSF 241
           L  +TG GC+  A   +F+++  +PL +      ++  AA    +K  E     GSF
Sbjct: 180 LALITGAGCLHAAACASFLSLKKDPLDSMAQLCALYKQAAFNAQKKVLENNGSNGSF 236


>sp|P76423|THIM_ECOLI HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE) >gi|7427961|pir||G64977
           hydroxyethylthiazole kinase (EC 2.7.1.50) - Escherichia
           coli (strain K-12) >gi|1736828|dbj|BAA15972.1| (D90848)
           Thi4 protein [Escherichia coli]
           >gi|1788421|gb|AAC75165.1| (AE000299)
           hydoxyethylthiazole kinase [Escherichia coli K12]
           Length = 262
           
 Score =  146 bits (366), Expect = 2e-34
 Identities = 93/248 (37%), Positives = 132/248 (52%), Gaps = 2/248 (0%)

Query: 10  ALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGT 69
           AL+   +  PLVH +TN VV   TAN LLALGASP M    EE  +   +A A++IN+GT
Sbjct: 14  ALHLFHQHSPLVHCMTNDVVQTFTANTLLALGASPAMVIETEEASQFAAIASALLINVGT 73

Query: 70  LDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVLKGNFGEISS 129
           L     ++M  AVE A   + P  LDPV  GA   R     E+L      ++GN  EI +
Sbjct: 74  LTQPRAQAMRAAVEQAKSSQTPWTLDPVAVGALDYRRHFCHELLSFKPAAIRGNASEIMA 133

Query: 130 LLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKL 189
           L G     RGVD+++     A   A + A+E    V VTG +DYV+DG ++  I+ G  L
Sbjct: 134 LAGIANGGRGVDTTD-AAANAIPAAQTLARETGAIVVVTGEMDYVTDGHRIIGIHGGDPL 192

Query: 190 LERVTGTGCIVTAITGAFVAVT-EPLRAAISSLVVFGIAAEKAYEEAKYPGSFHVKLYDW 248
           + +V GTGC ++A+  A  A+  + L    S+      A E+A   ++ PGSF     D 
Sbjct: 193 MTKVVGTGCALSAVVAACCALPGDTLENVASACHWMKQAGERAVARSEGPGSFVPHFLDA 252

Query: 249 LYRIDGEV 256
           L+++  EV
Sbjct: 253 LWQLTQEV 260


>sp|P55883|THIM_SALTY HYDROXYETHYLTHIAZOLE KINASE (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE
           KINASE) (THZ KINASE) (TH KINASE)
           >gi|1842117|gb|AAB66491.1| (U87940) hydroxyethyl
           thiazole kinase [Salmonella typhimurium]
           Length = 265
           
 Score =  145 bits (362), Expect = 5e-34
 Identities = 94/250 (37%), Positives = 133/250 (52%), Gaps = 10/250 (4%)

Query: 11  LNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTL 70
           L   R   PL H +TN VV   TAN LLALGASP M     E      +A+A++IN+GTL
Sbjct: 15  LKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPFAAIANALLINVGTL 74

Query: 71  DSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVLKGNFGEISSL 130
            +    +M  AVE A + K P  LDPV  GA + R +  L++L      ++GN  EI +L
Sbjct: 75  TASRADAMRAAVESAYDAKTPWTLDPVAVGALEFRRRFCLDLLSLRPAAIRGNASEILAL 134

Query: 131 LGEFGKTRGVDSSEYDEEKAKVLALSA----AKEFNTTVAVTGAVDYVSDGGKVFAIYNG 186
            G     RGVD++E     A + AL A    A++ +  V VTG +DYV++G +  +I  G
Sbjct: 135 SGMALGGRGVDTTE-----AALAALPAAQALARQIDCIVVVTGEIDYVTNGQRTLSIPGG 189

Query: 187 HKLLERVTGTGCIVTAITGAFVAVT-EPLRAAISSLVVFGIAAEKAYEEAKYPGSFHVKL 245
             L+ R+ GTGC ++A+  A  A+    L    S+     +A + A E ++ PGSF    
Sbjct: 190 DPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSEGPGSFIPAF 249

Query: 246 YDWLYRIDGE 255
            D LY +D E
Sbjct: 250 LDALYHLDVE 259


>dbj|BAA76743.1| (D88442) hydoxyethylthiazole kinase [Escherichia coli]
           Length = 235
           
 Score =  134 bits (335), Expect = 8e-31
 Identities = 86/234 (36%), Positives = 122/234 (51%), Gaps = 2/234 (0%)

Query: 24  ITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADAVVINIGTLDSWWRKSMIKAVE 83
           +TN VV   TAN LLALGASP M    EE  +   +A A++IN+GTL     ++M  AVE
Sbjct: 1   MTNDVVQTFTANTLLALGASPAMVIETEEASQFAAIASALLINVGTLTQPRAQAMRAAVE 60

Query: 84  IANEMKKPIVLDPVGAGATKLRTKVALEILDRGVTVLKGNFGEISSLLGEFGKTRGVDSS 143
            A   + P  LDPV  GA   R     E+L      ++GN  EI +L G     RGVD++
Sbjct: 61  QAKSSQTPWTLDPVAVGALDYRRHFCHELLSFKPAAIRGNASEIMALAGIANGGRGVDTT 120

Query: 144 EYDEEKAKVLALSAAKEFNTTVAVTGAVDYVSDGGKVFAIYNGHKLLERVTGTGCIVTAI 203
           +     A   A + A+E    V VTG +DYV+DG ++  I+ G  L+ +V GTGC +  +
Sbjct: 121 D-AAANAIPAAQTLARETGAIVVVTGEMDYVTDGHRIIGIHGGDPLMTKVVGTGCALXXV 179

Query: 204 TGAFVAVT-EPLRAAISSLVVFGIAAEKAYEEAKYPGSFHVKLYDWLYRIDGEV 256
             A  A+  + L    S+      A E+A   ++ PGSF     D L+++  EV
Sbjct: 180 VAACCALPGDTLENVASACHWMKQAGERAVARSEGPGSFVPHFLDALWQLTQEV 233


>dbj|BAA89257.1| (AB024693) OrfG [Leptospira interrogans serovar
           icterohaemorrhagiae]
           Length = 211
           
 Score =  127 bits (317), Expect = 1e-28
 Identities = 78/211 (36%), Positives = 121/211 (56%), Gaps = 2/211 (0%)

Query: 46  MAHAEEELEEMIGLADAVVINIGTLDSWWRKSMIKAVEIANEMKKPIVLDPVGAGATKLR 105
           M  A+EE  E   +A  ++INIGT+ S    +M  A E A++ K P VLDPV  GA   R
Sbjct: 1   MVIAKEEAGEFAKIASGLLINIGTVTSNDAITMKIAAEAAHQAKIPWVLDPVAVGALGFR 60

Query: 106 TKVALEILDRGVTVLKGNFGEISSLLGEFGKTRGVDSSEYDEEKAKVLALSAAKEFNTTV 165
           T++A E+L+   TV++GN  EI +L G  G  +GVDS+    + A  LA   A++    +
Sbjct: 61  TELAKELLNFKPTVIRGNASEILALAGTDGGGKGVDSTALSSD-ALPLAQMLAEKTGAVI 119

Query: 166 AVTGAVDYVSDGGKVFAIYNGHKLLERVTGTGCIVTAITGAFVAV-TEPLRAAISSLVVF 224
           A++G +DYV++G +  +I  G  ++ +VTG GC +  +  +F+ V  +PLRA  ++  VF
Sbjct: 120 AISGEIDYVTNGKETISISGGDPIMTKVTGVGCSLGGVIASFLGVQKDPLRATATASAVF 179

Query: 225 GIAAEKAYEEAKYPGSFHVKLYDWLYRIDGE 255
            IA  ++ + +K  GSF V   D L  +  E
Sbjct: 180 AIAGTRSAKISKGSGSFAVNFLDQLNLLSTE 210


>gi|6325042 TMP pyrophosphorylase, hydroxyethylthiazole kinase; Thi6p
           [Saccharomyces cerevisiae]
           >gi|1174673|sp|P41835|THI6_YEAST THIAMINE BIOSYNTHETIC
           BIFUNCTIONAL ENZYME [INCLUDES: THIAMINE-PHOSPHATE
           PYROPHOSPHORYLASE (TMP PYROPHOSPHORYLASE) (TMP-PPASE);
           HYDROXYETHYLTHIAZOLE KINASE
           (4-METHYL-5-BETA-HYDROXYETHYLTHIAZOLE KINASE) (THZ
           KINASE) (TH KINASE)] >gi|1078413|pir||A55145
           thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) /
           hydroxyethylthiazole kinase (EC 2.7.1.50) THI6 - yeast
           (Saccharomyces cerevisiae) >gi|633125|dbj|BAA06703.1|
           (D31908) thiamin biosynthetic bifunctional enzyme
           [Saccharomyces cerevisiae] >gi|1370444|emb|CAA97929.1|
           (Z73570) ORF YPL214c [Saccharomyces cerevisiae]
           Length = 540
           
 Score = 99.1 bits (243), Expect = 5e-20
 Identities = 80/276 (28%), Positives = 137/276 (48%), Gaps = 33/276 (11%)

Query: 7   IVEALNEVRKRKPLVHNITNFVVMNTTANALLALGASPVMAHAEEELEEMIGLADA-VVI 65
           I   +++V   +PLV +ITN V  N  AN  LALG+SP+M+  E E+ E+  + +A +++
Sbjct: 251 IQNVISQVSNNRPLVQHITNKVHQNFGANVTLALGSSPIMSEIESEVSELARIPNASLLL 310

Query: 66  NIGTLDSWWRKSMIK-AVEIANEMKKPIVLDPVGAGATKLRTKVALEILDRG-VTVLKGN 123
           N G++       M+K A+   NE+ +PI  DPVG  AT+ R  +   +L  G    +KGN
Sbjct: 311 NTGSVAP---IEMLKAAINAYNEVNRPITFDPVGYSATETRLCLNNTLLTYGQFACIKGN 367

Query: 124 FGEISSLLG-EFGKTRGVDSSEYDEEKAKVLALS--AAKEFNTTVAVTGAVDYVSDG--G 178
             EI SL      K +GVDSS        ++  +   A ++ T    TG  D V+DG  G
Sbjct: 368 CSEILSLAKLNNHKMKGVDSSSGKTNIDTLVRATQIVAFQYRTVAVCTGEFDCVADGTFG 427

Query: 179 KVFAIYNGHK------------------LLERVTGTGCIVTAITGAFV----AVTEPLRA 216
             + + +G +                  ++  +T +GC + +   +F+    +  +   A
Sbjct: 428 GEYKLSSGTEGITAEDLPCVIIEDGPIPIMGDITASGCSLGSTIASFIGGLDSTGKLFDA 487

Query: 217 AISSLVVFGIAAEKAYEEAKYPGSFHVKLYDWLYRI 252
            + +++++  A + A    +  GSFHV+L D LY++
Sbjct: 488 VVGAVLLYKSAGKLASTRCQGSGSFHVELIDALYQL 523


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.317    0.135    0.375 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90015569
Number of Sequences: 2977
Number of extensions: 3421715
Number of successful extensions: 14275
Number of sequences better than 1.0e-10: 19
Number of HSP's better than  0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 14220
Number of HSP's gapped (non-prelim): 19
length of query: 268
length of database: 189,106,746
effective HSP length: 59
effective length of query: 209
effective length of database: 153,796,013
effective search space: 32143366717
effective search space used: 32143366717
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 164 (68.3 bits)