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Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 1

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0124	0.0
Pyrococcus furiosus	Pf_118179	1e-134
Pyrococcus horikoshii	PH0197	1e-152
Aeropyrum pernix	APE1649	1e-13
Archaeoglobus fulgidus	AF2049	2e-13
Methanobacterium thermoautotrophicum
Methanococcus jannaschii	MJ1315	7e-98
Homologs in Eucarya
Human	AJ010842
Yeast	T41629 S. cerevisiae , BAA87234. S. pombe
Other	AAF04897.1  A. thaliana, AAF58067.1 D. melanogaster
Size of P. abyssi protein	357 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	AAF04897.1	2e-07	A. thaliana
Best Bacterial Hit	TM0907	0.056	T. maritima
Module (Pfam, Prosite, Prints)	PS00017 : ATP/GTP-binding site motif A - PR00449 : transforming protein P21 RAS
PRODOM domain	AAA
PDB hit	Signal recognition particle receptor
COG group	COG1341: Predicted GTPase or GTP-binding
KOG group	KOG2749 (Hs5803029) = Clp1 (pre-mRNA cleavage complex II) characterized in man in 2000 KOG2750 (Hs13375903)= uncharacterized ATP/GTP-binding protein associated to N-terminal presenilin in Spombe
Gene Environment in Archaea	Not conserved		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	Uncharacterized

Red= new annotations