10

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 10

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0759	1e-129	PAB0415
Pyrococcus furiosus	Pf_807782	1e-97	Pf_310341
Pyrococcus horikoshii	PH1257	1e-108	PH0375
Aeropyrum pernix	APE0421	7e-35	APE2042
Archaeoglobus fulgidus	AF1666	4e-54	AF0720
Methanobacterium thermoautotrophicum	MTH432	2e-61
Methanococcus jannaschii	MJ0570	8e-68
Homologs in Eucarya
Human
Yeast	CAA62663.1 ,YLR143w 1 S. cerevisiae , SPAC577.12 S pombe
Other	AAF63779.1 A. thaliana, AAF48097.1 D. melanogaster
Size of P. abyssi protein	226 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	CG1578	2e-25	D. melanogaster
Best Bacterial Hit	aq_1445	2.2	A. aeolicus
Module (Pfam, Prosite, Prints)	PF01902 : domain of unknown function DUF71
PRODOM domain
PDB hit
COG group	COG2102 : Predicted ATPases of PP-loop superfamily
KOG group	KOG2316 (Hs18087809) : Predicted ATPases of PP-loop superfamily
Gene Environment in Archaea	Not conserved : aiF-2/kinase/heat shock/RNA methyltransferase		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	Operational