11

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

 

 

PACE 11

Orthologs in Archaea

Gene

Blast Expect

Paralogs

Pyrococcus abyssi

PAB0944

5e-85

 

Pyrococcus furiosus

Pf_1033428

1e-71

 

Pyrococcus horikoshii

PH0624

7e-78

 

Aeropyrum pernix

 

 

 

Archaeoglobus fulgidus

AF2206

1e-18

 

Methanobacterium thermoautotrophicum

MTH1896

1e-25

 

Methanococcus jannaschii

MJ1030

1e-25

 

Homologs in Eucarya

Human

 

Yeast

YGR277c S. cerevisiae, C1F12.08 S. pombe

Other

AAD15511.1 A. thaliana

 

Size of P. abyssi protein

157 aa.

Best Hits outside Archaea

Gene

Blast Expect

 

Best Eucaryotic Hit

YGR277c

7e-17

S. cerevisiae

Best Bacterial Hit

aq_1368

0.001

 A. aeolicus

 

Module (Pfam, Prosite, Prints)

PF01467 : Cytidylyltransferase

PRODOM domain

Transferase cytidyltransferase nucleotidyltransderase

PDB hit

CTP : glycerol-3-phosphate cytidylyltranferase

COG group

COG1019 : Predicted nucleotidyltransferase

KOG group

KOG3351 (Hs21489977) = Predicted nucleotidyltransferase
PPAT (Armangaud J et al. 2003)

Gene Environment in Archaea

Not conserved:
NIFS-like/transcription regulation/(DNA topo)

See Environment

Phylogeny

 See Unrooted Distance Tree

 

Function Prediction

 Uncharacterized

Red= new annotations