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Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0955	1e-161
Pyrococcus furiosus	Pf_501670	1e-120
Pyrococcus horikoshii	PH0611	1e-129
Aeropyrum pernix	APE0791	6e-23
Archaeoglobus fulgidus	AF0539	8e-21	AF2209
Methanobacterium thermoautotrophicum
Methanococcus jannaschii
Homologs in Eucarya
Human	CAA09376.1 ATP(GTP)-binding protein
Yeast	Yjr072c Yor262wp S cerevisiae, SPBC119.15 SPAC144.07c T38803 S. pombe
Other	C34E10.2 Y75B8A.14 C. elegans , CG10222 BACR7A4.ab AAF54055.1 D. melanogaster, T8O5.10 A. thaliana

Size of P. abyssi protein	277 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	CAA09376.1	3e-20	H. sapiens
Best Bacterial Hit	TM1870	8.4e-02	T. maritima

Module (Pfam, Prosite, Prints)	PS00017 : ATP/GTP-binding site motif A - PR00819 : Cbx/Cfqx superfamily - PR00315 : GTP-binding elongation factor PR00195 : Dynamin family
PRODOM domain
PDB hit	nitrogenase iron
COG group	COG1100 : GTPase SAR1 and related small G proteins
KOG group	KOG1532 (Hs14149629) = GTPase XAB1, interacts with DNA repair protein XPA XPA is xeroderma pigmentosus group A protein, involved in nucleotide excision repair. XAB1 may be involved in nuclear localization of XPA. KOG1533 (Hs8922366) = Predicted GTPase KOG1534 (Hs21361523, HsM9994189) = Yeast putative transcription factor FET5
Gene Environment in Archaea	Not conserved: minD2//CDC21/(ribosomal proteins)	See Environment
Phylogeny	See Unrooted Distance Tree

Function Prediction	Informational : replication, repair / division

Red= new annotations